Entry Entry Name Protein names Gene Names Organism Gene Ontology (biological process) Gene Ontology (cellular component) Gene Ontology (molecular function) T: Peptide sequences N: Peptides N: Sequence coverage [%] N: Q-value N: Score Intensity CaCo2_Control_1 Intensity CaCo2_Control_2 Intensity CaCo2_Control_3 Intensity CaCo2_Red 8_1 Intensity CaCo2_Red 8_2 Intensity CaCo2_Red 8_3 Intensity SiHa_Control_1 Intensity SiHa_Control_2 Intensity SiHa_Control_3 Intensity SiHa_Red 8_1 Intensity SiHa_Red 8_2 Intensity Vero_Red 8_3 A0A024RBG1 NUD4B_HUMAN Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (DIPP-2B) (EC 3.6.1.52) (Nucleoside diphosphate-linked moiety X motif 4B) (Nudix motif 4B) (Nudix hydrolase 4B) NUDT4B Homo sapiens (Human) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] EVYEEAGVK;LLGIFEQNQDRK;TYDREGFK 3 16 0.98028 -2.0383 10.6741 0 0 8.24812 0 0 0 11.0323 0 0 0 0 A0A075B6I1 LV460_HUMAN Immunoglobulin lambda variable 4-60 IGLV4-60 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] YLMKLEGSGSYNKGSGVPDR 1 16.7 0.8516 -0.079704 0 0 7.19643 0 8.72983 0 0 0 0 0 0 0 A0A075B6I7 LV548_HUMAN Probable non-functional immunoglobulin lambda variable 5-48 IGLV5-48 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] IYWYQQKPGSPPR 1 12.4 0.89755 -0.2318 0 0 0 0 6.9364 0 0 0 0 0 0 0 A0A075B6L2 TVG11_HUMAN Probable non-functional T cell receptor gamma variable 11 TRGV11 Homo sapiens (Human) adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] EDEVVYHCACWIRH 1 11.8 0.87635 -0.12296 0 0 0 0 0 0 0 0 0 9.31816 0 0 A0A075B6R0 TRGV2_HUMAN T cell receptor gamma variable 2 TRGV2 TCRGV2 Homo sapiens (Human) adaptive immune response [GO:0002250]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101] VVLESGVSPGKYYTYASTR 1 16.1 0.91564 -0.43256 0 0 0 0 0 0 0 5.50684 0 0 0 0 A0A075B6R2 HV404_HUMAN Immunoglobulin heavy variable 4-4 IGHV4-4 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] SKNQFSLK 1 6.8 0.98119 -1.5907 0 0 0 0 0 0 0 8.60726 0 0 0 0 A0A075B6T7 TVA6_HUMAN T cell receptor alpha variable 6 TRAV6 TCRAV5S1 Homo sapiens (Human) adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] QDPGRGPVFLLLIR 1 10.6 0.92238 -0.44279 0 0 5.51333 0 0 0 0 0 0 0 0 0 A0A087WT02 TVA92_HUMAN T cell receptor alpha variable 9-2 TRAV9-2 Homo sapiens (Human) adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] ETTSFHLEK;GFEATYRK 2 15.2 0.88858 -0.20143 0 9.58086 0 0 0 0 0 0 0 0 5.75929 0 A0A087WTH1 TM265_HUMAN Transmembrane protein 265 TMEM265 Homo sapiens (Human) membrane [GO:0016020] CCWLRLR 1 6.5 0.93735 -0.54148 0 0 0 0 6.4739 7.6034 0 0 0 0 0 0 A0A087WUL8 NBPFJ_HUMAN NBPF family member NBPF19 (Neuroblastoma breakpoint family member 19) NBPF19 Homo sapiens (Human) cytoplasm [GO:0005737] EDQEATGPR;LSPENDNDDDEDVQVEVAEK;LSRELLAEKEPEVLQDPLDR 3 2.3 0.91322 -0.39024 12.1587 0 11.544 7.43846 7.44568 0 0 0 6.65277 0 0 0 A0A087WUV0 ZN892_HUMAN Zinc finger protein 892 ZNF892 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECGKAFSQSSSLSQHQK;ELTPEKDISEEESAPGVLIVR 2 7.3 0.95524 -0.86678 0 12.1499 0 0 0 6.48967 11.4918 0 0 0 0 0 A0A087WXM9 MEIKN_HUMAN Meiosis-specific kinetochore protein MEIKIN Homo sapiens (Human) "female meiosis chromosome segregation [GO:0016321]; homologous chromosome segregation [GO:0045143]; male meiosis chromosome segregation [GO:0007060]; meiotic sister chromatid cohesion involved in meiosis I [GO:0010789]; meiotic sister chromatid cohesion, centromeric [GO:0051754]" "condensed chromosome, centromeric region [GO:0000779]; kinetochore [GO:0000776]" APQFSNVSAIFSTSSEDYQKCHR;VHGLSKIAEK 2 8.8 0.96335 -1.0843 0 0 0 6.73863 7.25096 0 0 0 0 11.8844 10.9951 0 A0A087X179 TBC3E_HUMAN TBC1 domain family member 3E TBC1D3E Homo sapiens (Human) plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] SKWVDMLGDWEKYK;SSRKLIDQAYK;VRSAFAAPSTDSDQGTPFRAR 3 8.4 0.95228 -0.7412 0 12.4501 0 0 0 0 0 11.3455 9.43544 0 0 0 A0A096LNP1 D131B_HUMAN "Beta-defensin 131B (Defensin, beta 131)" DEFB131B Homo sapiens (Human) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular space [GO:0005615] SFTSNDECPSEYYHCR;SFTSNDECPSEYYHCRLK 2 25.7 0.71338 0.14829 0 5.83064 0 0 0 0 0 0 0 0 7.40854 7.71507 A0A096LP49 CC187_HUMAN Coiled-coil domain-containing protein 187 CCDC187 Homo sapiens (Human) microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] ASHGQGR;DAPVLLSASPSLGSLELQDLTTR;QAQLQALETTAK;QGPSSQRPGSPPEK 4 5.8 0.92267 -0.4422 9.21391 10.5276 0 0 0 7.3474 0 0 10.764 8.26927 9.77428 0 A0A0A6YYC5 TVA14_HUMAN T cell receptor alpha variable 14/delta variable 4 TRAV14DV4 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] immunoglobulin complex [GO:0019814]; T cell receptor complex [GO:0042101] ITQTQPGMFVQEK;SLSSLLKVVTASLWLGPGIAQK 2 30.2 0.81349 -0.0090827 0 12.5578 0 0 0 0 0 0 4.0336 0 0 0 A0A0A6YYD4 TVB13_HUMAN T cell receptor beta variable 13 TRBV13 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] LSPDLPDSAWNTR 1 10.5 0.8984 -0.2315 0 0 0 0 0 0 0 0 0 0 9.77246 0 A0A0A6YYK6 TVA16_HUMAN T cell receptor alpha variable 16 TRAV16 Homo sapiens (Human) adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] KPTLISVLVIIFILR;KPTLISVLVIIFILRGTR;VTQPEKLLSVFKGAPVELK 3 33.9 0.53323 0.18642 0 0 0 0 0 0 8.26233 0 6.1644 0 5.9762 4.93201 A0A0A6YYK7 TVA19_HUMAN T cell receptor alpha variable 19 (T-cell receptor alpha chain V region HPB-MLT) TRAV19 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605] AVIASICVVSSMAQK 1 12.9 0.84796 -0.071422 0 0 0 0 0 0 0 0 0 0 0 11.6225 A0A0B4J1U7 HV601_HUMAN Immunoglobulin heavy variable 6-1 IGHV6-1 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] WYNDYAVSVKSRITINPDTSK 1 17.4 0.52542 0.18665 0 0 0 8.86854 0 0 0 0 0 0 0 0 A0A0B4J1V0 HV315_HUMAN Immunoglobulin heavy variable 3-15 IGHV3-15 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] GLEWVGRIK 1 7.6 0.93366 -0.50017 0 0 0 0 0 0 0 0 0 6.99695 0 0 A0A0B4J1Y8 LV949_HUMAN Immunoglobulin lambda variable 9-49 IGLV9-49 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] VGTGGIVGSKGDGIPDR 1 13.8 0.91834 -0.43566 0 0 0 0 0 0 0 0 0 7.68902 0 0 A0A0B4J240 TVA10_HUMAN T cell receptor alpha variable 10 TRAV10 Homo sapiens (Human) adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] HLTTFLVILWLYFYRGNGK 1 16.7 0.95235 -0.67269 0 0 0 0 0 0 0 0 0 10.4276 0 0 A0A0B4J265 TVAZ2_HUMAN T cell receptor alpha variable 26-2 TRAV26-2 Homo sapiens (Human) adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] LVTSITVLLSLGIMGDAK 1 16.5 0.60758 0.17607 0 0 0 0 0 0 0 0 0 8.96979 0 0 A0A0B4J268 TVA4_HUMAN T cell receptor alpha variable 4 TRAV4 Homo sapiens (Human) adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] FIIQGYKTK;QVARVIVFLTLSTLSLAK 2 24.8 0.95155 -0.71421 7.37104 5.11524 0 0 0 0 0 0 0 0 0 0 A0A0B4J273 TVA34_HUMAN T cell receptor alpha variable 34 TRAV34 Homo sapiens (Human) adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] GGEEKSHEK;SHEKITAKLDEK 2 15.2 0.91694 -0.36197 0 0 0 0 0 0 7.76461 0 0 10.6193 0 0 A0A0C4DH25 KVD20_HUMAN Immunoglobulin kappa variable 3D-20 IGKV3D-20 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] LLIYDASSR 1 7.8 0.93556 -0.52765 0 0 0 0 10.0404 0 0 0 0 0 0 0 A0A0C4DH30 HV316_HUMAN Probable non-functional immunoglobulin heavy variable 3-16 IGHV3-16 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] THYVDSVK 1 6.8 0.93389 -0.51061 0 0 0 10.1371 0 0 0 0 0 0 0 0 A0A0C4DH67 KV108_HUMAN Immunoglobulin kappa variable 1-8 IGKV1-8 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] MRVPAQLLGLLLLWLPGAR;VPAQLLGLLLLWLPGAR 2 16.5 0.82952 -0.021857 0 0 0 0 0 8.69366 0 9.91754 0 0 0 0 A0A0D9SF12 CC163_HUMAN Transmembrane protein CCDC163 (Coiled-coil domain-containing protein 163) (coiled-coil domain containing 163 pseudogene) CCDC163 C1orf231 CCDC163P Homo sapiens (Human) membrane [GO:0016020] QLAEGRQAQVGSWKIPR 1 11.7 0.86441 -0.083961 0 0 0 0 0 0 0 0 0 0 8.56259 0 A0A0G2JS06 LV539_HUMAN Immunoglobulin lambda variable 5-39 IGLV5-39 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] YLLRYKSDSDK 1 8.9 0.86574 -0.088816 0 0 0 7.67631 0 0 0 0 0 0 0 0 A0A0J9YWL9 TX13C_HUMAN Putative testis-expressed protein 13C TEX13C Homo sapiens (Human) metal ion binding [GO:0046872]; mRNA binding [GO:0003729] FINNEVLRNGGSPAFYTAFR 1 2 0.91626 -0.43065 0 0 0 9.77464 0 0 0 0 0 0 0 0 A0A0J9YX57 MAB6B_HUMAN Melanoma-associated antigen B6B MAGEB6B Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] SDEAAKGQNEKSPSTSR;SSSSSSAVCQGARR 2 7.6 0.13285 0.3564 6.2645 0 0 7.30524 0 0 0 0 0 0 0 0 A0A0J9YXQ4 PMA6E_HUMAN Paraneoplastic antigen Ma6E PNMA6E Homo sapiens (Human) DMLQLWCHASEREK 1 2.2 0.92092 -0.44179 0 0 0 0 0 0 0 0 0 0 9.78614 0 A0A0J9YXX1 HV5X1_HUMAN Immunoglobulin heavy variable 5-10-1 IGHV5-10-1 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] ASDTAMYYCAR 1 9.4 0.29917 0.25188 0 9.50559 0 0 0 0 0 0 0 0 0 0 A0A0K0K1A5 TVB65_HUMAN T cell receptor beta variable 6-5 TRBV6-5 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] TGQSMTLQCAQDMNHEYMSWYR 1 19.3 0.89767 -0.23219 0 7.28817 0 0 0 0 0 0 0 0 0 0 A0A0K0K1C4 TVB27_HUMAN T cell receptor beta variable 27 TRBV27 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] KLTVTCSQNMNHEYMSWYR 1 16.7 0.32139 0.24782 0 0 0 0 0 0 0 0 9.07545 0 0 0 A0A0U1RQE8 GLYLB_HUMAN Putative glycine N-acyltransferase-like protein 1B (EC 2.3.1.68) GLYATL1B Homo sapiens (Human) glutamine metabolic process [GO:0006541] mitochondrion [GO:0005739] glutamine N-acyltransferase activity [GO:0047946]; glycine N-acyltransferase activity [GO:0047961] LIMRCMK;SIPESLK;SQEVLKNSEIINWKQK;YLCQKNIPFYGSVLEENQGVIRK 4 17.5 0.94122 -0.59856 0 0 0 6.88874 0 0 0 6.54035 6.916 0 0 7.81128 A0A0U1RR37 CA232_HUMAN Uncharacterized protein C1orf232 C1orf232 Homo sapiens (Human) WQQQQAAAASMLR 1 7 0.79714 0.014752 0 0 0 0 0 0 0 0 0 0 0 10.3608 A0A0U1RRK4 LBHD2_HUMAN LBH domain-containing protein 2 LBHD2 Homo sapiens (Human) AVAGAWEKGPR 1 10.2 0.98118 -1.5776 0 0 0 0 0 0 0 14.872 0 0 0 0 A0A183 LCE6A_HUMAN Late cornified envelope protein 6A LCE6A C1orf44 Homo sapiens (Human) keratinization [GO:0031424] GTTYHCKEEECEGD 1 17.5 0.88783 -0.18324 0 0 0 0 4.81281 0 0 0 0 0 0 0 A0A1B0GTC6 CC085_HUMAN Uncharacterized protein C3orf85 C3orf85 Homo sapiens (Human) ETWIALK 1 7.8 0.91096 -0.3269 0 0 0 0 0 0 0 0 0 11.4945 0 0 A0A1B0GTH6 CS2IP_HUMAN Casein kinase II subunit alpha'-interacting protein (Casein kinase 2 alpha prime interacting protein) CSNK2A2IP CSNKA2IP Homo sapiens (Human) nucleus [GO:0005634] MRGRPNPHPGPR;TNISGQLLSSSK;VIGQQPQAIDWLFYVK;VQSHSNHFAVPPLGSNK 4 7.8 0.96639 -1.2717 0 0 0 0 0 0 2.04527 0 9.60301 0 10.1829 9.93196 A0A1B0GTH9 ZN475_HUMAN Zinc finger protein 475 ZNF475 Homo sapiens (Human) metal ion binding [GO:0046872] SISIHEPQCLKKWHNENNLLPK 1 20.4 0.56189 0.18276 0 0 0 0 0 0 0 9.26019 0 0 0 0 A0A1B0GTK4 F237A_HUMAN Protein FAM237A FAM237A Homo sapiens (Human) extracellular region [GO:0005576] VSNTVSGFWDFMIYLKSSENLK 1 12.2 0.82939 -0.025381 0 0 0 0 0 0 8.93696 0 0 8.66885 0 0 A0A1B0GTQ4 MYMX_HUMAN Protein myomixer (Microprotein inducer of fusion) (Protein minion) (hMINION) MYMX Homo sapiens (Human) myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] LLLSCLLLPAAR;LLLSCLLLPAARLARQYLLPLLR;PTPLLPLLLRLLLSCLLLPAAR 3 39.3 0.9266 -0.45414 0 0 0 0 7.2538 0 0 0 0 0 0 9.88306 A0A1B0GTW7 CIROP_HUMAN Ciliated left-right organizer metallopeptidase (EC 3.4.24.-) (Leishmanolysin-like peptidase 2) CIROP LMLN2 Homo sapiens (Human) cell adhesion [GO:0007155]; establishment of left/right asymmetry [GO:0061966]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233] DPAQYCHAVWGDPDSPNYHR 1 2.9 0.64114 0.17351 0 0 0 0 0 0 0 0 0 0 0 6.62616 A0A1B0GTZ2 CC196_HUMAN Putative coiled-coil domain-containing protein 196 (Long intergenic non-protein coding RNA 238) CCDC196 C14orf53 LINC00238 NCRNA00238 Homo sapiens (Human) IDDNYLK 1 2.4 0.73129 0.12047 12.5544 0 12.7088 10.7298 11.2813 9.71522 0 0 9.59524 14.0909 0 11.6562 A0A1B0GUA9 CM046_HUMAN Uncharacterized protein C13orf46 C13orf46 Homo sapiens (Human) LGHESGKQDPER;MEKDTGTTHRR 2 10.8 0.90828 -0.27638 0 0 0 0 0 0 0 0 0 0 0 9.99237 A0A1B0GUS4 UB2L5_HUMAN Ubiquitin-conjugating enzyme E2 L5 (EC 2.3.2.23) (Ubiquitin-protein ligase L5) UBE2L5 Homo sapiens (Human) protein K11-linked ubiquitination [GO:0070979]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631] IEINFPAEYPFKPPR 1 9.7 0.78414 0.027073 0 0 0 4.92609 0 0 0 0 0 0 0 0 A0A1B0GUU1 CQ113_HUMAN Uncharacterized protein C17orf113 C17orf113 Homo sapiens (Human) EDVPNDRCSALLELQR;GLEWLRGSFLDSMRK 2 4.6 0.91732 -0.35405 0 0 0 0 0 0 0 0 9.68664 0 0 0 A0A1B0GUV1 CQ114_HUMAN Uncharacterized protein C17orf114 C17orf114 Homo sapiens (Human) GAWCFPWCGCR 1 13.9 0.81011 0.0098785 0 0 0 0 0 0 0 5.33928 0 0 0 0 A0A1B0GUV7 TEX48_HUMAN Testis-expressed protein 48 TEX48 Homo sapiens (Human) YCQEHWPFQPCLTGRP 1 13.3 0.78327 0.026223 0 0 0 0 0 0 0 0 0 0 3.25054 0 A0A1B0GUW7 SIM27_HUMAN Small integral membrane protein 27 (TOPORS antisense RNA 1) SMIM27 C9orf133 TOPORS-AS1 Homo sapiens (Human) membrane [GO:0016020] IFGTNENL 1 14.5 0.91784 -0.40157 0 0 0 0 0 0 10.5763 0 0 0 0 0 A0A1B0GUY1 MRCOL_HUMAN MARCO-like protein MARCOL Homo sapiens (Human) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AGVLNQPGILKNSGKSNQK;LEKPRHFKQGR;LQGQPGYFNKLEKPRHFK 3 14 0.95272 -0.67859 0 0 0 8.5567 9.62735 0 0 0 10.9029 0 0 0 A0A1B0GV03 GG6L7_HUMAN Golgin subfamily A member 6-like protein 7 GOLGA6L7 Homo sapiens (Human) cis-Golgi network [GO:0005801] KQEEQMGEQEEQMGEQEEQMRK;MWRQEQRLR;QEEQMGEQEEQMGEQEEQMR 3 5 0.88601 -0.18083 10.7655 11.3115 0 0 0 0 10.4182 0 0 0 0 0 A0A1B0GV85 RELD1_HUMAN Reelin domain-containing protein 1 REELD1 Homo sapiens (Human) membrane [GO:0016020] VSSESFASSLSTHHR 1 2.9 0.78338 0.026146 0 0 0 5.84434 0 0 0 0 0 0 0 0 A0A1B0GV96 CHD9N_HUMAN CHD9 neighbor protein CHD9NB Homo sapiens (Human) STTVAAESQKLEEER 1 28.8 0.91702 -0.43016 0 0 0 0 0 9.75059 0 0 0 0 0 0 A0A1B0GVB3 CG078_HUMAN Putative uncharacterized protein C7orf78 C7orf78 Homo sapiens (Human) DPFGLKFK;MKVNVWEIKPPDFSYK;MKVNVWEIKPPDFSYKLYTSLR;TSTERFITHKHCECTWDSK 4 24 0.98158 -1.7715 0 4.59192 10.7689 0 0 0 0 0 0 0 5.12969 0 A0A1B0GVG6 TEX54_HUMAN Testis-expressed protein 54 TEX54 Homo sapiens (Human) EDETTDTQRGPR;GCCQDKDFEMSDEQSK;MGCCQDK;MGCCQDKDFEMSDEQSK 4 23.4 0.91221 -0.32819 3.59204 0 4.56712 0 0 0 0 0 0 0 9.42978 1.75258 A0A1B0GVH4 PRS51_HUMAN Serine protease-like protein 51 PRSS51 Homo sapiens (Human) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] FQLLIPLLLALK 1 5.5 0.30742 0.24922 0 0 7.22949 0 0 0 0 0 0 0 0 0 A0A1B0GVH6 CM042_HUMAN Uncharacterized protein C13orf42 C13orf42 Homo sapiens (Human) IHSIFNSSPQRK;LERHPIYLPK 2 6.8 0.81612 -0.016716 0 0 0 7.75549 0 0 0 0 3.18047 0 8.49945 8.4851 A0A1B0GVH7 IQCM_HUMAN IQ domain-containing protein M IQCM Homo sapiens (Human) IGPHIEIFQVFR;ISFKEPHIFSRR 2 4.8 0.8457 -0.060078 0 7.04396 0 0 0 0 0 0 0 0 0 0 A0A1B0GVM5 ETDC_HUMAN Embryonic testis differentiation protein homolog C ETDC Homo sapiens (Human) NVQVFLINR 1 15.3 0.84601 -0.065078 0 0 0 0 0 0 10.4235 0 0 0 0 0 A0A1B0GVR7 F240C_HUMAN Protein FAM240C FAM240C Homo sapiens (Human) CPDRVPEATESLHTKDK 1 17.9 0.42843 0.1956 0 0 0 0 0 0 8.74113 0 0 0 0 0 A0A1B0GVX0 LITAD_HUMAN LITAF domain-containing protein (LITAF-like protein) LITAFD Homo sapiens (Human) regulation of cytokine production [GO:0001817] cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634] zinc ion binding [GO:0008270] ELFYYHR 1 9.7 0.90984 -0.31014 0 10.1712 0 0 0 0 0 9.06628 0 0 0 0 A0A1B0GVZ6 MB3LB_HUMAN Methyl-CpG-binding domain protein 3-like 2B MBD3L2B Homo sapiens (Human) DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] methyl-CpG binding [GO:0008327] AGAERVR 1 3.4 0.96472 -1.2281 0 0 0 0 9.65769 0 0 0 0 0 0 9.80037 A0A1B0GW54 SIM39_HUMAN Small integral membrane protein 39 SMIM39 Homo sapiens (Human) membrane [GO:0016020] VVVSAVLALLVLINVVLIFLLAFR 1 42.9 0.71101 0.15634 0 0 0 0 0 0 0 0 0 5.67503 0 0 A0A1B0GWB2 PRT1B_HUMAN Proline rich transmembrane protein 1B PRRT1B IFITMD8 Homo sapiens (Human) membrane [GO:0016020] EAGAGGAGSDTKGGGSPATPEDPR 1 9.1 0.9259 -0.45201 5.31448 0 0 0 0 0 0 0 0 0 0 0 A0A1B0GX56 TRDV1_HUMAN T cell receptor delta variable 1 TRDV1 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087] immunoglobulin complex [GO:0019814]; T cell receptor complex [GO:0042101] EMIFLIR;EMIFLIRQGSDEQNAK;SVALTISALQLEDSAK;VTQAQSSVSMPVR 4 39.1 0.98095 -1.777 13.0038 0 0 7.75174 0 0 0 0 9.99676 11.7107 0 0 A0A1B0GX68 TVB2_HUMAN T cell receptor beta variable 2 TRBV2 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] CVPISNHLYFYWYR;LEDSAMYFCASSE 2 23.5 0.61144 0.1748 0 0 0 7.63503 0 0 0 9.22301 0 5.39637 0 0 A0A1W2PP97 THSD8_HUMAN Thrombospondin type-1 domain-containing protein 8 THSD8 Homo sapiens (Human) CLCDLGKQERSR 1 10.4 0.76677 0.058517 0 0 11.3462 0 0 0 0 0 0 0 0 0 A0A1W2PPM1 CPHXL_HUMAN Cytoplasmic polyadenylated homeobox-like protein (Cytoplasmic polyadenylated homeobox 1) CPHXL CPHX1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QSLSGAQR 1 2 0.74398 0.10231 0 0 0 0 0 0 0 0 7.78156 0 0 0 A0A1W2PQ72 MSD7_HUMAN Myb/SANT-like DNA-binding domain-containing protein 7 MSANTD7 Homo sapiens (Human) SVARTIAAELAENR 1 3.9 0.95191 -0.68448 0 0 0 0 7.71225 0 0 0 0 0 0 0 A0A1W2PQJ5 S72L3_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 3 (RNA polymerase II subunit A C-terminal domain phosphatase SSU72L3) (CTD phosphatase SSU72L3) (EC 3.1.3.16) SSU72L3 Homo sapiens (Human) mRNA processing [GO:0006397]; termination of RNA polymerase II transcription [GO:0006369] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] YTRNGILHILGRNER 1 7.7 0.86026 -0.082552 0 0 0 0 0 0 0 0 0 0 2.90265 0 A0A1W2PR19 GSTT4_HUMAN Glutathione S-transferase theta-4 (EC 2.5.1.18) (GST class-theta-4) (Glutathione S-transferase theta pseudogene 1) GSTT4 GSTTP1 Homo sapiens (Human) glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737] glutathione transferase activity [GO:0004364] ENISELLKK 1 3.7 0.74468 0.08976 0 0 0 0 0 0 0 0 0 0 0 7.50303 A0A1W2PR95 IGB1C_HUMAN Immunoglobulin-binding protein 1 family member C IGBP1C IGBP1P2 Homo sapiens (Human) regulation of dephosphorylation [GO:0035303]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829] protein phosphatase 2A binding [GO:0051721] RLDHLQQAREHFIK 1 4.1 0.58393 0.17976 0 0 0 0 0 0 0 0 0 3.24118 0 0 A0A1W2PRP0 FOXL3_HUMAN Forkhead box protein L3 FOXL3 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPPASPAPPGKEHPR 1 6.4 0.982 -1.5882 0 0 0 0 0 0 0 0 0 10.6931 0 0 A0A286YEV6 SCGR4_HUMAN Small cysteine and glycine repeat-containing protein 4 (Keratin-associated protein 28-4) SCYGR4 KRTAP28-4 Homo sapiens (Human) intermediate filament [GO:0005882] CCCQKQCCC;CGGGCGGGCSGGCGGGCGGGCGGGCGSCTTCR;CYRVGCCSSCCPCCR;GCCGCGSCGGCGGR;GCCGGCCSTPVICCCR;GCCQQKCCCQK;GCCQQKCCCQKQCCC;MGCCGCGSCGGCGGR 8 88.6 0.88933 -0.20487 4.90386 9.93759 0 4.94846 0 4.17871 1.92075 0 0 0 0 7.14802 A0A286YEX9 SCGRX_HUMAN Small cysteine and glycine repeat-containing protein 10 (Keratin-associated protein 28 family pseudogene 2) SCYGR10 KRTAP28p2 Homo sapiens (Human) intermediate filament [GO:0005882] CCCQKQCCC;GCCGGCCSTPVICCCR;MGCCGCGGCGGR;SCGCGCGKSCCQQKCCCQK;YYRVGCCSSCCPCCR 5 62.9 0.92106 -0.4444 0 4.37246 0 0 0 0 5.68488 6.65378 0 0 0 0 A0A286YEY9 SCGR1_HUMAN Small cysteine and glycine repeat-containing protein 1 (Keratin-associated protein 28-1) SCYGR1 KRTAP28-1 Homo sapiens (Human) intermediate filament [GO:0005882] CCCQKQCCC;CTTCRCYRVGCCSSCCPCCR;CYRVGCCSSCCPCCR;GCCGCGGCGGCGGCGGGCGGGCGR;GCCGGCCSTPVICCCR;GCCQQKCCCQK;GCCQQKCCCQKQCCC;TCSSCGYSCGK;TCSSCGYSCGKGCCQQK 9 97.7 0.96487 -1.2252 6.33748 0 7.6094 6.86009 0 4.32819 0 8.43575 0 5.8728 6.049 8.48325 A0A286YF18 SMI44_HUMAN Small integral membrane protein 44 SMIM44 Homo sapiens (Human) membrane [GO:0016020] DLAHDLADWAFGPKPDQEAAPR;LPRYVLYLLLAALVVVAVAYAIVGHLIK 2 33.6 0.83665 -0.030491 0 0 0 0 0 0 0 0 0 0 5.54089 7.34421 A0A286YF46 SCGR5_HUMAN Small cysteine and glycine repeat-containing protein 5 (Keratin-associated protein 28-5) SCYGR5 KRTAP28-5 Homo sapiens (Human) intermediate filament [GO:0005882] CYRVGCCSSCCPCCR;GCCGCGGCGGCGGGCGGGCGSCTTCR;GCCGGCCSTPVICCCR;GCCQKQCCC;MGCCGCGGCGGCGGGCGGGCGSCTTCR;TCCSCGCGCGKGCCQQK 6 98.8 0.81384 -0.0062471 0 0 0 7.21839 0 5.70055 5.2712 0 0 0 0 4.52042 A0A286YF58 TM271_HUMAN Transmembrane protein 271 TMEM271 Homo sapiens (Human) membrane [GO:0016020] GLVLSTVFNSLECLLGLLSLLLVK 1 6.2 0.71066 0.15634 0 0 0 0 0 0 0 0 0 0 5.36957 0 A0A286YF77 SCGR6_HUMAN Small cysteine and glycine repeat-containing protein 6 (Keratin-associated protein 28-6) SCYGR6 KRTAP28-6 Homo sapiens (Human) intermediate filament [GO:0005882] CYRVGCCSSCCPCCR;GCCGGCCSTPVICCCR;GCCQQKGCCK;TCHSCGCGCGCGK 4 51.4 0.88966 -0.20419 9.49452 5.01912 0 5.01386 0 0 0 0 5.04967 0 0 0 A0A286YFB4 SCGR2_HUMAN Small cysteine and glycine repeat-containing protein 2 (Keratin-associated protein 28-2) SCYGR2 KRTAP28-2 Homo sapiens (Human) intermediate filament [GO:0005882] CCCQKQCCC;CYRVGCCSSCCPCCR;GCCGGCCSTPVICCCR;GCCQQKCCCQK;GCCQQKCCCQKQCCC;MGCCGCGGCGGCGGR;RTCHSCGCGCGK;TCHSCGCGCGK;TCHSCGCGCGKGCCQQKCCCQK 9 60.8 0.91122 -0.32557 0 7.49354 0 0 0 5.88938 5.31803 0 0 0 0 3.01733 A0A286YFG1 SCGR8_HUMAN Small cysteine and glycine repeat-containing protein 8 (Keratin-associated protein 28-8) SCYGR8 KRTAP28-8 Homo sapiens (Human) intermediate filament [GO:0005882] CCCQKQCCC;CYRVGCCSSCCPCCR;GCCGGCCSTPVICCCR;GCCQQKCCCQK;GCCQQKCCCQKQCCC;RTCSSCGCGYGKGCCQQK 6 59.3 0.86575 -0.088346 0 0 0 0 3.09638 0 0 0 0 0 0 0 A0A2R8Y7Y5 CIST1_HUMAN Protein CIST1 (Colon intestine and stomach enriched-protein 1) CIST1 Homo sapiens (Human) membrane [GO:0016020] MACPQLPPLLLLVLVVLLK 1 8.1 0.78264 0.024186 5.08678 0 10.939 0 0 0 10.7256 0 0 0 4.30188 0 A0A2R8YED5 O5BS1_HUMAN Olfactory receptor 5BS1 (Olfactory receptor family 5 subfamily BS member 1) OR5BS1 OR5BS1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] INSATGRSK 1 2.9 0.9014 -0.2604 0 0 0 0 0 0 10.6605 10.2608 0 0 0 0 A0A2R8YFL7 OSP4A_HUMAN Oocyte-secreted protein 4A OOSP4A Homo sapiens (Human) extracellular region [GO:0005576] ISCVLGK;SLSHELEDLEIRPR 2 11.4 0.95545 -0.87266 0 0 0 0 0 8.88344 0 0 0 0 0 0 A0A3B3IS91 PLGRF_HUMAN POLG alternative reading frame (POLGARF) (ORF-Y) [Cleaved into: POLGARF C-terminal fragment (POLGARFin)] POLGARF Homo sapiens (Human) extracellular space [GO:0005615]; nucleolus [GO:0005730] ARAGSSSGALGLQLRPRVRPQR;GAGPGVR;GAGPGVRR 3 11.5 0.22372 0.31164 17.8568 0 0 15.5239 10.9841 11.845 0 0 16.6426 0 0 16.4422 A0A3B3IT33 TR51G_HUMAN Putative tripartite motif-containing protein 51G (Tripartite motif-containing 51G pseudogene) TRIM51G TRIM51GP Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] NLNMATNRIR 1 2.2 0.91624 -0.43328 0 7.19505 0 0 0 0 0 0 0 0 0 0 A0A3B3IT52 MSD5_HUMAN Putative uncharacterized protein MSANTD5 (Myb/SANT DNA binding domain-containing protein 5) MSANTD5 Homo sapiens (Human) AIAQRLKQR 1 4.2 0.83239 -0.026763 0 0 0 0 0 0 0 0 0 7.63227 0 0 A0A3B3IU63 H2AL3_HUMAN Histone H2A-like 3 (H2A.L.3) H2AL3 H2AL1RP Homo sapiens (Human) heterochromatin formation [GO:0031507] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] RQRLSHSR 1 5.4 0.97826 -1.5114 0 0 0 9.98185 0 0 0 0 0 0 0 0 A0A494C071 PWWP4_HUMAN PWWP domain-containing DNA repair factor 4 PWWP4 Homo sapiens (Human) AIAPTPGALRCDRSR;AIAPTPGALRGDR;AIASTPATLRGEKSR;AIASTPGALRGNRSDR;AISLEVQILAVDEK;ASWDRDNQKLVDFIVR;AVAPILGALHRVGSQAHK;DDRSQEPTAIAPTPGALPGDR;EPATTHTAN;RAIAPTPGTLSSYRSR;SGVSKATAPAPGALCSERSR;TATAPSPGALRGDR 12 9.7 0.97659 -5.5052 0 12.1235 10.9867 10.0705 10.0355 11.0747 11.8434 8.31601 0 6.38647 0 9.76871 A0A494C086 SPD21_HUMAN Putative speedy protein E21 SPDYE21 Homo sapiens (Human) protein kinase binding [GO:0019901] ITTSRQLHPQNEQSPQR;NRSQIVLFQKLR;YRSRIPLVR 3 9.5 0.97816 -1.5265 0 5.51794 0 11.9047 0 11.9624 0 0 0 13.3103 8.62483 0 A0A576 TVB31_HUMAN T cell receptor beta variable 3-1 TRBV3-1 TCRBV9S1A1T Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] IMFSYNNKELIINETVPNRFSPK 1 20.2 0.86554 -0.091958 0 0 0 6.87762 0 7.22728 0 0 0 7.2538 7.04865 0 A0A5B6 TVB28_HUMAN T cell receptor beta variable 28 TRBV28 TCRBV3S1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] LIYFSYDVK;VAFCFLAVGLVDVK 2 20.2 0.91565 -0.33902 0 0 0 0 0 0 0 0 0 0 0 8.01976 A0A5F9ZHS7 NFILZ_HUMAN NFIL3 like protein (NFIL3 like basic leucine zipper) NFILZ Homo sapiens (Human) circadian rhythm [GO:0007623]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] VPRGWEGGQAPL 1 4.2 0.98025 -1.5718 0 0 0 0 0 0 0 0 0 0 0 8.95292 A0A7P0TBJ1 HAPR2_HUMAN HUWE1-associated protein modifying stress responses 2 HAPSTR2 Homo sapiens (Human) protein stabilization [GO:0050821] nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] DVLEWVKK 1 2.9 0.84038 -0.043952 0 0 0 0 0 0 0 0 0 0 0 11.8446 A0AUZ9 KAL1L_HUMAN KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2) KANSL1L C2orf67 Homo sapiens (Human) intracellular membrane-bounded organelle [GO:0043231]; NSL complex [GO:0044545] histone acetyltransferase binding [GO:0035035] HFGSPQSSK;IQNSSRNTAR;NSRAYSK;QSAQLTEIINSLIAPLNLSPTSSPLSSK;TRPLQSFHKRK;WHRRNSR 6 7 0.97473 -2.3844 3.48078 0 8.14466 0 9.10085 8.24108 0 0 9.02627 0 9.28341 10.6505 A0AV96 RBM47_HUMAN RNA-binding protein 47 (RNA-binding motif protein 47) RBM47 Homo sapiens (Human) "3'-UTR-mediated mRNA stabilization [GO:0070935]; cytidine to uridine editing [GO:0016554]; hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634] enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ELNNYEIRPGR;EQYSRYQK 2 3.2 0.91546 -0.39556 0 0 11.2922 5.60469 0 0 0 0 0 0 0 0 A0AVF1 IFT56_HUMAN Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26) IFT56 TTC26 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; manchette assembly [GO:1905198]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; neuron projection [GO:0043005] intraciliary transport particle B binding [GO:0120170] AAEAELK;AATGNTSEGEEAFLLIQSEKMK;ETLREVLHLLR;LDPNPEYWEGK;RDFTGAITLLEFK 5 11.6 0.97272 -2.6118 0 0 0 0 0 0 7.38215 8.6418 8.80181 0 11.4102 0 A0AVI2 FR1L5_HUMAN Fer-1-like protein 5 FER1L5 Homo sapiens (Human) regulation of neurotransmitter secretion [GO:0046928] plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] ALSSKPQHFQVRVK;DLSHEVTRIEKHQNR;ERFIGLATVLLKPLLK;FIGLATVLLKPLLK;GLPPPLFSPEEDAVFYNGKK;KDWVVELNHAVDSK;LYQEQPK;TNTSFTWLRSPVQNFCYIFWK 8 5.2 0.97354 -2.5451 0 0 12.8929 9.44141 11.4237 4.04334 8.6084 11.246 0 5.34038 0 0 A0AVI4 TM129_HUMAN E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129) TMEM129 Homo sapiens (Human) "ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LFLLLAVTLPSIACILIYYWSR 1 6.1 0.67901 0.1655 0 0 0 0 0 0 0 11.4879 0 0 0 0 A0AVK6 E2F8_HUMAN Transcription factor E2F8 (E2F-8) E2F8 Homo sapiens (Human) cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; fibroblast proliferation [GO:0048144]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RGLFDNRSGLPEAK 1 1.6 0.76581 0.064481 0 0 0 0 0 8.38591 0 0 0 0 0 0 A0AVT1 UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) UBA6 MOP4 UBE1L2 Homo sapiens (Human) amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; nucleotidyltransferase activity [GO:0016779]; thiosulfate sulfurtransferase activity [GO:0004792]; ubiquitin activating enzyme activity [GO:0004839] MLKNFALLGVGTSK;YYFSHDTD 2 3.8 0.95499 -0.83273 0 0 5.73663 0 0 7.02746 7.25153 0 0 6.98311 0 0 A0FGR8 ESYT2_HUMAN Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) ESYT2 FAM62B KIAA1228 Homo sapiens (Human) endocytosis [GO:0006897]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091] GKLHLRLEWLTLMPNASNLDK;VDVGQQPLR;VGNQIFQSR 3 4.2 0.92186 -0.44281 0 0 0 0 0 10.8582 0 0 9.90674 10.7078 0 0 A0FGR9 ESYT3_HUMAN Extended synaptotagmin-3 (E-Syt3) (Chr3Syt) ESYT3 FAM62C Homo sapiens (Human) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091] ELGSPYTGPEALK 1 1.5 0.80504 0.01372 0 0 0 0 0 0 0 0 0 0 0 5.42415 A0JD36 TRDV2_HUMAN T cell receptor delta variable 2 TRDV2 hDV102S1 Homo sapiens (Human) adaptive immune response [GO:0002250]; innate immune response [GO:0045087] T cell receptor complex [GO:0042101] DEGSYYCACDT 1 9.6 0.89515 -0.24267 0 0 0 0 0 0 0 0 0 3.88372 0 0 A0JNW5 BLT3B_HUMAN Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) BLTP3B KIAA0701 SHIP164 UHRF1BP1L Homo sapiens (Human) early endosome to Golgi transport [GO:0034498]; intermembrane lipid transfer [GO:0120009] cytosol [GO:0005829]; early endosome [GO:0005769] GARP complex binding [GO:0062069]; lipid transfer activity [GO:0120013]; protein homodimerization activity [GO:0042803] AGDSCNHWMYFSDATK;DSFYTDSSSILNYR;LFNDFDVK;SMSVDLSHIPLKDPLLFKSASDTNLQK;SPNGPSPIATASGQSEYGFAEK 5 5.9 0.88276 -0.17129 6.38729 0 0 8.2375 6.66761 7.31741 0 6.89736 0 7.64623 0 0 A0M8Q6 IGLC7_HUMAN Immunoglobulin lambda constant 7 (Ig lambda-7 chain C region) IGLC7 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886] antigen binding [GO:0003823] VGVETTKPSK 1 9.4 0.88203 -0.16665 8.32841 8.79432 0 0 0 0 0 0 0 0 0 0 A0MZ66 SHOT1_HUMAN Shootin-1 (Shootin1) SHTN1 KIAA1598 Homo sapiens (Human) "actin filament bundle retrograde transport [GO:0061573]; axonogenesis [GO:0007409]; Cdc42 protein signal transduction [GO:0032488]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; endoplasmic reticulum polarization [GO:0061163]; netrin-activated signaling pathway [GO:0038007]; neuron projection morphogenesis [GO:0048812]; positive regulation of axon extension [GO:0045773]; positive regulation of neuron migration [GO:2001224]; Ras protein signal transduction [GO:0007265]; regulation of establishment of cell polarity [GO:2000114]; substrate-dependent cell migration, cell extension [GO:0006930]" axon [GO:0030424]; axonal growth cone [GO:0044295]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894] DPTQHKEDEGEIQPENKEDSIENVR;EIHNLKQQLELLEEDK;LTQQLEEER;MPRILKQCDK;QEKTVLNSEVLEQRK 5 12.5 0.98034 -1.805 11.3588 9.4315 0 0 0 0 0 0 0 0 8.04816 9.58385 A0PG75 PLS5_HUMAN Phospholipid scramblase family member 5 PLSCR5 Homo sapiens (Human) plasma membrane phospholipid scrambling [GO:0017121] plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] FTIQNANK;MASKDAQNQR 2 6.9 0.95477 -0.79805 0 0 0 0 0 0 0 0 0 7.83908 0 0 A0PJE2 DHR12_HUMAN Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 40C member 1) (Protein SDR40C1) DHRS12 SDR40C1 Homo sapiens (Human) oxidoreductase activity [GO:0016491] TLSLMTWR 1 3.3 0.93642 -0.55157 0 0 10.3467 10.4897 0 0 0 0 0 0 0 0 A0PJK1 SC5AA_HUMAN Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10) SLC5A10 SGLT5 Homo sapiens (Human) hexose transmembrane transport [GO:0008645] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; fructose:sodium symporter activity [GO:0140930]; mannose:sodium symporter activity [GO:0140929]; solute:sodium symporter activity [GO:0015370] TIANTTCHLPR 1 1.8 0.78636 0.017547 0 0 0 0 0 0 0 0 0 0 0 6.46361 A0PJW8 DAPL1_HUMAN Death-associated protein-like 1 (Early epithelial differentiation-associated protein) DAPL1 EEDA Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; ribosome hibernation [GO:0141014]" ribosome binding [GO:0043022]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371] VVPLKRIYIIQQPR 1 13.1 0.27037 0.25745 0 8.65703 0 0 0 0 0 0 0 0 0 0 A0PJX8 TMM82_HUMAN Transmembrane protein 82 TMEM82 Homo sapiens (Human) membrane [GO:0016020] TLNLLLSLGLATLLGLGARR 1 5.8 0.30374 0.24938 13.4543 0 0 0 9.35052 0 0 0 9.38396 0 0 0 A0PJZ3 GXLT2_HUMAN Glucoside xylosyltransferase 2 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 4) GXYLT2 GLT8D4 Homo sapiens (Human) O-glycan processing [GO:0016266] membrane [GO:0016020] "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]" AAALLLLALAALLLALLSLR;LLRLFNSTQLAAMAPEHEIPK;LRSKAAALLLLALAALLLALLSLR;SKAAALLLLALAALLLALLSLRAGR 4 10.8 0.37112 0.22408 5.11566 0 0 5.91679 0 0 0 7.58601 0 5.06031 4.89234 4.88108 A0PK00 T120B_HUMAN Transmembrane protein 120B TMEM120B Homo sapiens (Human) fat cell differentiation [GO:0045444]; protein heterooligomerization [GO:0051291] nuclear inner membrane [GO:0005637] ERQDVFFDMEAYLPKK 1 4.7 0.43881 0.1946 0 0 0 0 0 0 0 10.0885 0 0 0 0 A0PK05 TMM72_HUMAN Transmembrane protein 72 (Kidney-specific secretory protein of 37 kDa) TMEM72 C10orf127 KSP37 Homo sapiens (Human) membrane [GO:0016020] LIITGLAYFLLSK 1 8.3 0.89733 -0.23912 0 0 0 3.71732 0 0 0 0 0 0 0 0 A1A4G5 LNP1_HUMAN Leukemia NUP98 fusion partner 1 LNP1 NP3 Homo sapiens (Human) IEKFSESFER;SASLGPESRKER 2 12.4 0.91285 -0.3895 0 0 8.84828 0 0 0 0 0 2.811 0 0 0 A1A4S6 RHG10_HUMAN Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) ARHGAP10 GRAF2 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; endosome membrane [GO:0010008]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] HLNLSAKK;LLSMLMDVK;LQEIQERKK;NLIAATK 4 4.2 0.97414 -2.4589 8.07473 0 9.86836 0 0 0 0 0 0 0 0 0 A1A4V9 CF119_HUMAN Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189) CFAP119 C16orf93 CCDC189 Homo sapiens (Human) acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] EVLAELLELGCPEQSLR 1 5.1 0.78316 0.030262 0 0 0 0 0 0 4.2458 0 0 0 0 0 A1A4V9 CF119_HUMAN Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189) CFAP119 C16orf93 CCDC189 Homo sapiens (Human) acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] MGLQPPK;MGLQPPKLWPESETEK 2 15.5 0.93345 -0.50815 0 0 0 0 0 0 9.87871 0 0 0 10.4398 0 A1A519 F170A_HUMAN Protein FAM170A (Zinc finger domain-containing protein) (Zinc finger protein ZNFD) FAM170A ZNFD Homo sapiens (Human) fertilization [GO:0009566]; positive regulation of DNA-templated transcription [GO:0045893]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EGFSCPKMSR 1 4.1 0.88553 -0.19411 8.04264 0 0 0 0 0 0 0 0 0 0 0 A1A580 KR231_HUMAN Keratin-associated protein 23-1 KRTAP23-1 KAP23.1 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] SYNCCCGNFSSHSCEGYLCYSGYSR 1 38.5 0.71133 0.15167 0 0 0 0 0 5.05537 0 0 0 0 0 0 A1A5B4 ANO9_HUMAN Anoctamin-9 (Transmembrane protein 16J) (Tumor protein p53-inducible protein 5) (p53-induced gene 5 protein) ANO9 PIG5 TMEM16J TP53I5 Homo sapiens (Human) calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; monoatomic ion transmembrane transport [GO:0034220]; sensory perception of smell [GO:0007608] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; channel activity [GO:0015267]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; intracellularly calcium-gated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] IVNFVVMNNK;SLRASESGHLPR 2 2.8 0.91615 -0.43341 0 0 0 0 9.0989 0 0 0 0 0 7.00933 0 A1A5C7 S22AN_HUMAN Solute carrier family 22 member 23 SLC22A23 C6orf85 Homo sapiens (Human) monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] RGGLLLFMILTALASLLQLGLLNLIGK 1 3.9 0.37884 0.22075 0 0 0 0 0 3.28133 0 0 0 0 0 0 A1E959 ODAM_HUMAN Odontogenic ameloblast-associated protein (Apin) ODAM APIN Homo sapiens (Human) biomineral tissue development [GO:0031214]; inflammatory response [GO:0006954]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein phosphorylation [GO:0001934]; regulation of actin cytoskeleton organization [GO:0032956] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512] KIIILLGFLGATLSAPLIPQR 1 7.5 0.32686 0.24526 0 0 7.36623 0 0 0 0 0 0 0 0 0 A1IGU5 ARH37_HUMAN Rho guanine nucleotide exchange factor 37 ARHGEF37 Homo sapiens (Human) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] INTHTLSK;LDKLLDFERVEEK;WLVDTGGHR 3 4.4 0.97154 -1.3499 0 0 10.3483 0 0 0 0 0 0 0 0 10.394 A1KZ92 PXDNL_HUMAN Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2) PXDNL VPO2 Homo sapiens (Human) hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] endonuclease activity [GO:0004519]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] EFRYNDLVSPRSLSLIANLSGCTAR;FNRIREIPGSAFK;GLGLPVGSRQPLPPPRLVATVWAR;LFCWTTLFLLAGWCLPGLPCPSRCLCFK;LKNLNTLLLNNNHIR;LNVFDDGTLMIRNTR;NSAGEAK;VWQDCCADCRSRGQFR 8 9.8 0.97962 -1.8444 14.751 8.18448 5.20992 13.093 12.9724 12.8831 9.90561 0 9.87478 9.52863 0 13.5452 A1L020 MEX3A_HUMAN RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) MEX3A RKHD4 Homo sapiens (Human) cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] metal ion binding [GO:0046872]; RNA binding [GO:0003723] LGGGGLR;NKSGAAFGVAPALPGQVTIR;RIQQQTNTYIITPSR;VRVPYRVVGLVVGPK 4 11 0.87385 -0.10828 3.87027 0 0 0 0 0 7.80761 0 0 6.33753 10.0253 0 A1L0T0 HACL2_HUMAN 2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein) ILVBL AHAS HACL2 Homo sapiens (Human) fatty acid alpha-oxidation [GO:0001561]; isoleucine biosynthetic process [GO:0009097]; L-valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; lyase activity [GO:0016829]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] GALQAVDQLSLFRPLCK;TDFRDGSIAV;VLSHSSK 3 5.4 0.95357 -0.77681 0 0 9.33514 0 0 8.23554 0 0 0 0 0 0 A1L162 ERIC2_HUMAN Glutamate-rich protein 2 ERICH2 Homo sapiens (Human) GESDEELSDESSDEGEDGS;LSESAEDDGEDDTNDEDDDEDSNPK;TQNHEQDGENSDEDSSGESK 3 41 0.16643 0.34629 0 0 0 0 5.73148 0 4.48716 0 0 5.8835 0 0 A1L390 PKHG3_HUMAN Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) PLEKHG3 KIAA0599 Homo sapiens (Human) regulation of cell migration [GO:0030334]; regulation of establishment of cell polarity [GO:2000114]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AAGMKGK;EIVETERMYVQDLR;SNKPVMARPPLQWEKVAPERDGK;SSGFGSPRLVSR;TVEEKRNWTHHIK 5 5.7 0.97313 -2.6535 0 0 0 8.46455 0 0 13.4239 10.6725 0 11.6208 0 0 A1L3X4 MT1DP_HUMAN Putative metallothionein MT1DP MT1DP MTM Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] CTSCKKNCCSCCPMGCAK;DLSCSCATGGSCTCASSCK;DLSCSCATGGSCTCASSCKCK;KNCCSCCPMGCAK;NCCSCCPMGCAK 5 79.6 0.60775 0.17641 0 0 5.83933 0 7.09117 6.9751 5.59207 0 5.23913 0 6.29484 0 A1L453 PRS38_HUMAN Serine protease 38 (EC 3.4.21.-) (Marapsin-2) PRSS38 MPN2 Homo sapiens (Human) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] AAPASVMGPLGPSALGLLLLLLVVAPPR 1 8.6 0.7149 0.14212 0 0 0 9.9382 0 0 0 0 0 0 0 0 A1L4H1 SRCRL_HUMAN Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; negative regulation of interleukin-8 production [GO:0032717] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; scavenger receptor activity [GO:0005044] VHGDTGSPR;WTSHTTATLTPQAPRERTTK 2 1.8 0.94475 -0.63914 0 0 7.26294 0 9.28478 0 7.75722 0 0 0 0 0 A1L4K1 FSD2_HUMAN Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1) FSD2 SPRYD1 Homo sapiens (Human) nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529] DAVAMADRLGKFLK;DPAREQR 2 2.8 0.98045 -1.6822 0 8.96956 0 0 0 3.0537 0 0 0 0 0 10.0344 A1X283 SPD2B_HUMAN SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) SH3PXD2B FAD49 KIAA1295 TKS4 Homo sapiens (Human) adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; podosome assembly [GO:0071800]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176]" IGENREK;RYSKFFDLQMQMLDK;YSKFFDLQMQMLDK 3 2.4 0.97209 -2.7135 0 0 0 0 0 0 0 0 0 9.7903 10.7788 0 A1XBS5 CBAR1_HUMAN CBY1-interacting BAR domain-containing protein 1 CIBAR1 FAM92A FAM92A1 Homo sapiens (Human) cilium assembly [GO:0060271]; inner mitochondrial membrane organization [GO:0007007]; limb morphogenesis [GO:0035108]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] phospholipid binding [GO:0005543] HLEETINNFERQK 1 4.5 0.88823 -0.18365 0 10.2292 0 0 0 0 0 0 0 0 0 0 A1YPR0 ZBT7C_HUMAN Zinc finger and BTB domain-containing protein 7C (Affected by papillomavirus DNA integration in ME180 cells protein 1) (APM-1) (Zinc finger and BTB domain-containing protein 36) (Zinc finger protein 857C) ZBTB7C APM1 ZBTB36 ZNF857C Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHMRKHTGERPYLCIHCNAK 1 3.2 0.85042 -0.075825 0 0 0 0 0 0 0 0 0 0 0 8.87489 A1Z1Q3 MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-) MACROD2 C20orf133 Homo sapiens (Human) brain development [GO:0007420]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]; response to bacterium [GO:0009617] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]" ITCGYDLPAK;LVKENNIR 2 4.2 0.98133 -1.6992 12.3713 8.9782 0 0 0 0 0 0 9.21682 0 0 0 A2A288 ZC12D_HUMAN Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) ZC3H12D C6orf95 MCPIP4 TFL Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] GSPDLAALR;LVCYDDRYIVK 2 3.8 0.97905 -1.5326 12.6872 9.88608 9.81401 0 0 0 0 0 0 11.6152 0 0 A2A2Y4 FRMD3_HUMAN FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O) FRMD3 EPB41L4O Homo sapiens (Human) actomyosin structure organization [GO:0031032] cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092] LGSKVTARNTGVPLPK 1 7.5 0.85018 -0.075976 0 0 0 3.92828 0 0 0 0 0 0 0 0 A2A2Y4 FRMD3_HUMAN FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O) FRMD3 EPB41L4O Homo sapiens (Human) actomyosin structure organization [GO:0031032] cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092] EELTRYLLYLQIK;ETKGQFLIDHICNYYSLLEK;RETKGQFLIDHICNYYSLLEK 3 6.1 0.9514 -0.69231 0 0 0 9.28649 0 0 0 0 0 0 4.39897 6.39282 A2A368 MAGBG_HUMAN Melanoma-associated antigen B16 (MAGE-B16 antigen) MAGEB16 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] AETSKMK;GVPKTGLLIIVLGVIFMK 2 7.7 0.91107 -0.28717 8.80129 0 0 5.28592 0 0 0 0 0 0 0 0 A2A3K4 PTPC1_HUMAN Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) PTPDC1 PTP9Q22 Homo sapiens (Human) cilium assembly [GO:0060271] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] protein tyrosine phosphatase activity [GO:0004725] EFTQFLTPLR;YHIIDQFLSHGIK 2 3.1 0.89776 -0.23538 0 7.94158 0 0 7.1468 0 0 0 0 0 0 0 A2A3L6 TTC24_HUMAN Tetratricopeptide repeat protein 24 (TPR repeat protein 24) TTC24 Homo sapiens (Human) AFLLASK;KEERSANVPVR;MSSPNPEDVPRRPEPEPSSSNKK;QEASIQALTR 4 8.8 0.97259 -2.744 6.58248 9.89115 0 5.52629 0 9.91791 0 0 0 0 0 0 A2AJT9 BCLA3_HUMAN BCLAF1 and THRAP3 family member 3 BCLAF3 CXorf23 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592]; mitochondrion [GO:0005739] DNA binding [GO:0003677]; transcription coregulator activity [GO:0003712] FSTMQDIHK;GGKPPQRSIADSFR;GLALSPR;IQEEKYSQSTRR;SIADSFRFEGK;YSFQKGPLNR 6 9 0.97377 -2.4653 0 0 0 10.0169 0 8.24174 11.5806 0 0 0 10.601 10.0523 A2CJ06 DYTN_HUMAN Dystrotelin DYTN Homo sapiens (Human) synaptic signaling [GO:0099536] plasma membrane [GO:0005886]; synapse [GO:0045202] zinc ion binding [GO:0008270] LDEVDRSHR;VISALPSYQEGLKQDIPK 2 4.7 0.95164 -0.69518 4.07391 0 0 0 0 0 0 8.61202 0 0 6.02498 0 A2IDD5 CCD78_HUMAN Coiled-coil domain-containing protein 78 (hsCCDC78) CCDC78 C16orf25 JFP10 Homo sapiens (Human) cell projection organization [GO:0030030]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; skeletal muscle contraction [GO:0003009] centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] AAGQRLATQAVVLCSCQGQLR 1 4.8 0.82743 -0.021489 0 0 0 0 0 7.38543 0 0 0 0 0 0 A2PYH4 HFM1_HUMAN Probable ATP-dependent DNA helicase HFM1 (EC 3.6.4.12) (SEC63 domain-containing protein 1) HFM1 SEC3D1 Homo sapiens (Human) resolution of meiotic recombination intermediates [GO:0000712] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; nucleic acid binding [GO:0003676]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FYTISGKETLSDLVTLIAGCKEFLDIQLR;INEKKTLNTLNK;ITRWLSDFVAAQEK;KFAVLLNSLILAK;LPLQESKSKFQR;LTVFYLEPKR;MKTVQSVSQTLKNTSTAIPMR;SIFKEFPYFNYIQSK;TKISGFGNTLSSSTRGSK;YAYSVRDSKLR 10 10.8 0.9752 -4.0425 17.2016 17.0937 17.1851 12.3181 15.345 6.41239 0 10.7924 0 17.419 10.2577 0 A2RRD8 ZN320_HUMAN Zinc finger protein 320 ZNF320 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATLACHHR;ATLACHHRSHTGEKPYK;CHQCGKVFSLR;HYTCNECGK;TLYRDVMLENYR 5 9.6 0.98049 -1.6099 0 3.16615 0 9.16428 0 10.8959 0 0 0 0 5.05233 0 A2RRH5 WDR27_HUMAN WD repeat-containing protein 27 WDR27 Homo sapiens (Human) nucleoplasm [GO:0005654] DQRLVFHSK;NVMKDQRLVFHSK 2 1.6 0.97454 -1.3806 0 0 0 0 0 9.31393 0 0 0 9.83118 0 0 A2RRL7 TM213_HUMAN Transmembrane protein 213 TMEM213 Homo sapiens (Human) membrane [GO:0016020] FCTVLCFWESRR 1 11.4 0.84097 -0.041387 2.30615 0 0 0 0 0 0 0 0 0 0 12.3809 A2RRP1 NBAS_HUMAN NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) NBAS NAG Homo sapiens (Human) "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] SNARE binding [GO:0000149] GKPHYRVSYEK;GVDVQRFTADDQYK;LLMNSCSEDK;LLTYLDR;NDQLCLCYDLLECLPER;VLEGVVAAVHASVDK;VPENVDAAK 7 3.5 0.98074 -1.7779 0 0 9.00149 0 0 6.16507 5.65085 4.40524 9.24738 0 11.0235 0 A2RTX5 SYTC2_HUMAN "Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3)" TARS3 TARSL2 Homo sapiens (Human) threonyl-tRNA aminoacylation [GO:0006435] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; threonine-tRNA ligase activity [GO:0004829] IRNAQLAQYNFILVVGEKEK;LEVSKEILLEMFKYNK;QEEDIRWLWSEVER 3 6.2 0.97569 -1.4635 0 12.713 0 0 0 0 4.419 0 0 0 0 0 A2RTY3 HEAT9_HUMAN Protein HEATR9 (HEAT repeat-containing protein 9) HEATR9 C17orf66 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] HVIRALIKQLK;SPQVFHLLLDLLDAENHQAVK;SRPLEPTQDPLKWQR;TQVGDEGK 4 9.6 0.95235 -0.73936 0 10.7611 9.69545 0 0 0 3.68145 5.19472 0 0 0 0 A2RU30 TESP1_HUMAN Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) TESPA1 KIAA0748 HSPC257 Homo sapiens (Human) COP9 signalosome assembly [GO:0010387]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization [GO:0008104]; T cell differentiation in thymus [GO:0033077]; TCR signalosome assembly [GO:0036399] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; TCR signalosome [GO:0036398] phospholipase binding [GO:0043274]; signaling receptor binding [GO:0005102] EPEPQSPR;NLMGRKVK 2 3.1 0.9532 -0.77789 0 0 0 0 0 0 0 0 10.7186 0 0 0 A2RU37 CI170_HUMAN Uncharacterized protein encoded by LINC02872 (Long intergenic non-protein coding RNA 2872) LINC02872 C9orf170 Homo sapiens (Human) SDLGVGSPDWK 1 9.1 0.89683 -0.23601 0 0 0 0 0 0 0 0 10.8122 0 0 0 A2RU48 SMCO3_HUMAN Single-pass membrane and coiled-coil domain-containing protein 3 SMCO3 C12orf69 Homo sapiens (Human) membrane [GO:0016020] LQDIKEK;TQLQAAIKSYEKHLVEFK 2 11.1 0.96646 -1.1288 0 0 0 0 0 7.72281 0 0 0 0 0 0 A2RU49 HYKK_HUMAN Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) lysine catabolic process [GO:0006554] mitochondrial matrix [GO:0005759] amino acid kinase activity [GO:0019202]; hydroxylysine kinase activity [GO:0047992] EEVMTKLSHFR;NREIVEHVIHLFK 2 6.4 0.96499 -1.2523 0 0 0 0 6.11582 0 0 0 0 5.89142 0 0 A2RU54 HMX2_HUMAN Homeobox protein HMX2 (Homeobox protein H6 family member 2) HMX2 Homo sapiens (Human) "brain development [GO:0007420]; cell differentiation [GO:0030154]; epithelial cell proliferation [GO:0050673]; inner ear morphogenesis [GO:0042472]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell proliferation [GO:0072089]" chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" HHPPIPFPCLGTPK;VPVPRSLAFPAPLYYPGSNLSALPLYNLYNK 2 16.5 0.93669 -0.52484 0 0 0 0 0 0 0 0 0 0 8.6591 0 A2RUB1 MEIOC_HUMAN Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein) MEIOC C17orf104 Homo sapiens (Human) "chromosome organization involved in meiotic cell cycle [GO:0070192]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; male meiosis I [GO:0007141]; metaphase chromosome alignment [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]" cytoplasm [GO:0005737]; nucleus [GO:0005634] KVSSTNNTPVPR;KVSSTNNTPVPRLTSNPSR;LNSHLSAASK;VVTLLGK 4 3.8 0.97986 -1.5386 0 0 0 0 9.89488 0 10.4144 8.02203 0 0 0 0 A2RUB6 CCD66_HUMAN Coiled-coil domain-containing protein 66 CCDC66 Homo sapiens (Human) cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; microtubule bundle formation [GO:0001578]; regulation of protein localization to cilium [GO:1903564]; retina homeostasis [GO:0001895] cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; Flemming body [GO:0090543]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] DITNCSSPEISAELIGQFSTK;ELAQKGHDTSR;KNKQELTQDK;WIEELNK 4 5.2 0.97468 -3.2455 0 0 0 0 0 0 0 12.2223 0 8.37452 10.1833 0 A2RUC4 TYW5_HUMAN tRNA wybutosine-synthesizing protein 5 (hTYW5) (tRNA yW-synthesizing protein 5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 C2orf60 Homo sapiens (Human) wybutosine biosynthetic process [GO:0031591] cytoplasm [GO:0005737] iron ion binding [GO:0005506]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity [GO:0102524] AYSKNSE;MVLHIQDKAYSK 2 4.8 0.97832 -2.0714 0 0 0 0 0 0 0 10.7093 0 0 11.9425 0 A2RUH7 MBPHL_HUMAN Myosin-binding protein H-like MYBPHL Homo sapiens (Human) in utero embryonic development [GO:0001701] myofilament [GO:0036379]; sarcomere [GO:0030017] EAQRADSGR;MDIQGNPKYRALTHLGICSLEIR 2 9 0.97537 -1.4319 0 0 0 0 0 6.79299 0 0 0 0 0 0 A2RUQ5 CQ102_HUMAN Uncharacterized protein TMEM132E-DT (TMEM132E divergent transcript) TMEM132E-DT C17orf102 Homo sapiens (Human) GHPTPTPRVRWALAGNQPR 1 11.4 0.44329 0.1941 0 0 0 0 0 0 0 0 0 0 0 8.61894 A2RUR9 C144A_HUMAN Coiled-coil domain-containing protein 144A CCDC144A KIAA0565 Homo sapiens (Human) AEWHKLLIEER;DALGRESLILERVQR;DLSQTQCQK;EDNTTSIK;ELMDEYNHLK;ETEQMYQIEQSKLKK;ILNSELENGK;LEIDTIKNQNKQK;LEWKNQLK;QILSLQEKNK;TQMELTIK;VDMSGLQAK;VVETKQQLKWNLR;YFEDIEAVKEK 14 10.5 0.97918 -1.8801 0 0 0 9.29882 0 0 0 5.70797 11.0112 0 0 0 A2RUS2 DEND3_HUMAN DENN domain-containing protein 3 DENND3 KIAA0870 Homo sapiens (Human) endosome to lysosome transport [GO:0008333]; protein catabolic process [GO:0030163]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] GLGQGTPK;QVWVGSRGLGQGTPKGK;VASKKEVFEANLK;VEDAHPK 4 3.1 0.96467 -1.1534 0 8.1058 0 0 0 0 8.27305 0 0 0 0 7.76944 A2RUT3 TMM89_HUMAN Transmembrane protein 89 TMEM89 Homo sapiens (Human) membrane [GO:0016020]; nucleus [GO:0005634] GVLHMLDALLVHIEGHLR 1 11.3 0.64933 0.17047 0 0 0 0 0 0 0 0 0 8.6714 0 0 A2RUU4 COLL1_HUMAN Colipase-like protein 1 CLPSL1 C6orf127 Homo sapiens (Human) digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094] extracellular region [GO:0005576] enzyme activator activity [GO:0008047] YNLLELKESCIR 1 9.9 0.92513 -0.45116 0 0 7.82318 0 0 0 0 0 0 0 0 0 A2VCK2 DCD2B_HUMAN Doublecortin domain-containing protein 2B DCDC2B Homo sapiens (Human) intracellular signal transduction [GO:0035556] microtubule [GO:0005874]; microtubule organizing center [GO:0005815] AQVTQPSPK;VKLQSGAVCK 2 5.4 0.97954 -1.842 0 0 0 0 0 0 0 0 0 0 0 8.83589 A2VDJ0 T131L_HUMAN Transmembrane protein 131-like TMEM131L KIAA0922 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] CSVYYSKHK;KYKNGDVCK;VIPAMGK 3 1.6 0.97459 -2.4026 0 0 0 0 0 0 9.14832 0 0 0 0 11.1166 A2VEC9 SSPO_HUMAN SCO-spondin (SCO-spondin pseudogene) SSPOP KIAA2036 SSPO Homo sapiens (Human) cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] CDLRPDCQDGSDEDGCVDCVLAPWSVWSSCSR;CDQEEDCADGSDER;CQTEPCEGCEHQGQVHRVGERWHGGPCR;EAGCPAGRLYR;GWRCDQEEDCADGSDER;GWRCDQEEDCADGSDERGCGGPCAPHHAPCAR;LDLPWSGR;QLCNPCVCR;RYAPGSATMK;SAEQCHQEGGPCPR;VQCLQGPCRPGCRCPPGQLVQDGR;WRKPGFCER 12 3.4 0.97449 -3.665 11.3711 0 9.3823 0 0 7.55382 0 5.15866 10.4775 3.80405 7.99283 12.2017 A3KMH1 VWA8_HUMAN von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2) VWA8 KIAA0564 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DTAGLGGK;GQVVLHEQQSNVILLLDTTGRALHR;HAIQWLYPYSILLGHEGKMAVEGVLK;HGKEDPDNMPHVGGNTWAGGTGGR;LWETGLERLQRSLMEWR;SLNFTEECASWR;VEKMMENHVSQASVTIR 7 6.8 0.9722 -2.8263 0 0 0 9.34928 0 0 0 10.5286 0 0 9.86851 0 A3KN83 SBNO1_HUMAN Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) SBNO1 MOP3 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone binding [GO:0042393] KKLFLVYRPNTGK 1 0.9 0.87033 -0.094457 0 0 0 5.86074 0 0 6.14327 0 0 7.02447 0 0 A3QJZ6 PRA22_HUMAN PRAME family member 22 PRAMEF22 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GHLDQLIR;LQVLELR;YLSQMRNLRK 3 5.2 0.9785 -1.9222 0 0 0 0 14.2567 0 0 0 0 9.85031 0 10.8262 A4D0S4 LAMB4_HUMAN Laminin subunit beta-4 (Laminin beta-1-related protein) LAMB4 Homo sapiens (Human) cell adhesion [GO:0007155] basement membrane [GO:0005604]; extracellular region [GO:0005576] LGYGGKR;VKNFLLEENVPPEDIEK;VTGECLR 3 1.8 0.93277 -0.50163 0 7.79565 0 0 0 0 0 0 8.89999 0 0 12.5461 A4D0V7 CPED1_HUMAN Cadherin-like and PC-esterase domain-containing protein 1 CPED1 C7orf58 UNQ9432/PRO34713 Homo sapiens (Human) endoplasmic reticulum [GO:0005783] AILYRPPFYSK;LQTFFETFLR;LSKEYNFIKMK 3 3.1 0.9364 -0.5589 12.2026 0 0 0 0 0 0 0 0 0 0 0 A4D126 ISPD_HUMAN D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein) (hISPD) CRPPA ISPD Homo sapiens (Human) axon guidance [GO:0007411]; isoprenoid biosynthetic process [GO:0008299]; protein O-linked mannosylation [GO:0035269] cytosol [GO:0005829] cytidylyltransferase activity [GO:0070567]; D-ribitol-5-phosphate cytidylyltransferase activity [GO:0047349]; protein homodimerization activity [GO:0042803] LVEGSPDLWK 1 2.2 0.93711 -0.55482 0 10.1819 0 0 0 0 0 0 0 0 0 0 A4D1B5 GSAP_HUMAN Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)] GSAP PION Homo sapiens (Human) positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162] trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540] LKFSIIVRLPPLIGQK;LVNFGCDYHQYRDK 2 3.5 0.49787 0.18916 0 0 0 0 0 0 0 7.04067 0 0 0 0 A4D1B5 GSAP_HUMAN Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)] GSAP PION Homo sapiens (Human) positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162] trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540] ADLNTNRVLSDFLK;LVNFGCDYHQYRDK 2 4.9 0.92874 -0.46377 0 0 0 0 0 0 5.30173 0 0 0 9.92348 0 A4D1B5 GSAP_HUMAN Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)] GSAP PION Homo sapiens (Human) positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162] trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540] LKFSIIVRLPPLIGQK;MGLMVSELK 2 10.1 0.93459 -0.53047 0 0 0 0 0 10.8415 0 0 0 0 0 0 A4D1E1 Z804B_HUMAN Zinc finger protein 804B ZNF804B Homo sapiens (Human) nucleus [GO:0005634] metal ion binding [GO:0046872] GVFRGPLCK;IENREKSLDK;ILQLQAQQHMQKQLLSKHLR;LDSYSIEKMYYLNK;LIPCSPHLEFEDER;SNIHLSDVDFTPTSR 6 6.1 0.97592 -2.2563 0 0 11.8759 0 0 0 11.2149 0 0 11.9554 0 0 A4D1E9 GTPBA_HUMAN GTP-binding protein 10 (Protein obg homolog 2) (ObgH2) GTPBP10 OBGH2 UG0751c10 Homo sapiens (Human) ribosome biogenesis [GO:0042254] chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723] LGGEGGK 1 1.8 0.81203 0.0025375 0 0 13.2718 0 0 0 0 0 0 0 0 0 A4D1F6 LRRD1_HUMAN Leucine-rich repeat and death domain-containing protein 1 LRRD1 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737] IKELQLADNK;ISSDICNLK 2 2.2 0.97789 -2.1644 0 0 0 0 0 0 0 0 0 6.71699 11.1988 0 A4D1N5 YG018_HUMAN Putative uncharacterized protein FLJ40288 Homo sapiens (Human) HSRELGP 1 4.7 0.90185 -0.26216 0 0 0 7.57493 0 0 0 0 0 0 0 0 A4D1P6 WDR91_HUMAN WD repeat-containing protein 91 WDR91 HSPC049 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; regulation of protein catabolic process [GO:0042176] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902] phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] DYWSYLERRLFSR;QKLFALQAEIHRLK 2 3.6 0.97539 -1.4402 0 0 0 12.1788 0 0 0 15.207 15.241 2.94548 13.5242 0 A4D1S0 KLRG2_HUMAN Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) KLRG2 CLEC15B Homo sapiens (Human) membrane [GO:0016020] carbohydrate binding [GO:0030246] AAGAGLEPSSK 1 2.7 0.93531 -0.52925 0 0 0 0 0 0 0 9.21138 0 0 0 0 A4D1T9 PRS37_HUMAN Probable inactive serine protease 37 (Probable inactive trypsin-X2) PRSS37 TRYX2 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; cell migration [GO:0016477]; germ cell migration [GO:0008354]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of protein processing [GO:0070613] acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; nucleus [GO:0005634] serine-type endopeptidase activity [GO:0004252] HPDLRQNLEAPVMSDRECQK;SHRNSLCVK 2 12.3 0.96641 -1.2634 0 0 0 0 0 0 8.85779 10.9124 0 0 0 0 A4D1U4 DEN11_HUMAN DENN domain-containing protein 11 (DENND11) (Protein LCHN) DENND11 KIAA1147 LCHN Homo sapiens (Human) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] HQLEMPGHYSHLAAFYEDKK 1 4.4 0.30536 0.24938 0 0 0 0 7.42282 0 0 0 0 0 0 0 A4D256 CC14C_HUMAN Dual specificity protein phosphatase CDC14C (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog C) CDC14C CDC14B2 CDC14Bretro Homo sapiens (Human) cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle pole [GO:0000922] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" QTSLWLEGDYFRQR;SSTLQDPR 2 4.9 0.95857 -1.0049 0 0 0 0 8.53962 0 0 10.7207 0 0 0 0 A4D263 SMIP7_HUMAN Protein SPMIP7 (Sperm microtubule inner protein 7) (Spermatogenesis-associated protein 48) SPMIP7 C7orf72 SPATA48 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] DVEIQDTPGK;GLENRHNYGR;ILSEELQQNR;LGGWTSPLK;MDVEIQDTPGKISISK 5 10.3 0.98 -1.8739 10.5332 0 0 0 0 0 0 0 0 0 11.1071 10.5416 A4D2B0 MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) MBLAC1 Homo sapiens (Human) histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521] GPASSHR 1 2.6 0.94089 -0.58829 0 0 0 0 0 0 0 0 0 8.60796 0 0 A4D2B8 PM2P1_HUMAN Putative postmeiotic segregation increased 2-like protein 1 (PMS2-related protein 2) (Postmeiotic segregation increased 2-like protein 13) (Postmeiotic segregation increased 2-like protein 6) (Postmeiotic segregation increased 2-like protein 8) (Postmeiotic segregation increased protein 3) (hPMS3) (Postmeiotic segregation increased protein 8) (Putative postmeiotic segregation increased 2 pseudogene 1) PMS2P1 PMS2L1 PMS2L13 PMS2L6 PMS2L8 PMS3 PMS8 PMSR2 Homo sapiens (Human) mismatch repair [GO:0006298] mismatch repair complex [GO:0032300] ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; kinase activity [GO:0016301] ATTSLLTLLLAFGKNAVR;GGNFPSPRGGSGVASLER;LVFDHYGKIIQK 3 10.9 0.97727 -2.2347 0 0 0 0 0 0 0 0 10.7866 0 17.4211 0 A4D2P6 GRD2I_HUMAN "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" GRID2IP Homo sapiens (Human) long-term synaptic depression [GO:0060292]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] "cerebellar granule cell to Purkinje cell synapse [GO:0150048]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]" ALSDLQAGEGLR 1 1 0.80674 0.012172 0 0 0 0 0 0 0 0 7.79513 0 0 0 A4FU01 MTMRB_HUMAN Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11) MTMR11 Homo sapiens (Human) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] ISPEDHSKK 1 1.3 0.92963 -0.47516 0 0 0 10.5593 0 0 0 0 0 0 0 0 A4FU49 SH321_HUMAN SH3 domain-containing protein 21 SH3D21 C1orf113 Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GWWEGECQGRR;LATATTGPSKAKR 2 17.8 0.86757 -0.093099 0 0 0 0 5.3917 0 0 0 0 0 0 0 A4FU49 SH321_HUMAN SH3 domain-containing protein 21 SH3D21 C1orf113 Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EEVPPIERAFAQK;EIEDGWWLGKK;GSGEARRPR;GWWEGECQGRR;RLEVQVMQGTQK;VPTPEKMVTPEDK 6 9.1 0.95597 -0.98282 0 0 0 6.4046 0 0 10.8806 0 11.4414 0 0 0 A4FU69 EFCB5_HUMAN EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) calcium ion binding [GO:0005509] FYVNKYLVNNICAFDPTAK;ISIEEQQQGK;IYVPDTICNRVSKMK;MNALEQFSQNAFQVRQR;QLNSGITPPLPSK;SLLRNPR;TGEALGVLDFNIGQNRMLLCQEYK 7 7 0.97537 -2.3523 0 0 10.1994 8.048 0 11.0236 0 0 12.5047 0 0 0 A4FU69 EFCB5_HUMAN EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) calcium ion binding [GO:0005509] ESMKKDHSR;ISIEEQQQGK;IYVPDTICNRVSKMK;MNALEQFSQNAFQVRQR;QLNSGITPPLPSK;SLLRNPR 6 7.3 0.97487 -1.4358 0 0 0 0 0 0 0 0 0 11.7645 0 0 A4FU69 EFCB5_HUMAN EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) calcium ion binding [GO:0005509] ISIEEQQQGK;IYVPDTICNRVSKMK;LLSNWDYRER;LLSNWDYRERR;SLLRNPR 5 5 0.97708 -1.4976 8.34904 0 0 0 0 0 0 0 0 0 10.4166 0 A4GXA9 EME2_HUMAN Probable crossover junction endonuclease EME2 (EC 3.1.22.-) EME2 Homo sapiens (Human) double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596] DNA binding [GO:0003677]; endonuclease activity [GO:0004519] ARDPAGERR;ASPDPCPR;GGSGQRRPPTWEISDSDAEDSAGSEAAAR;VGPDLSR;VGPDLSRR 5 14.2 0.96352 -1.0894 0 0 0 0 8.27104 8.06383 0 6.34928 0 8.99008 0 10.1919 A4QMS7 CFA90_HUMAN Cilia- and flagella-associated protein 90 CFAP90 C5orf49 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal B tubule inner sheath [GO:0160112]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] LDYDQKLHRDDR;LHRDDREHAK 2 10.9 0.9625 -1.1034 0 0 0 0 0 0 0 0 9.0324 0 0 10.1319 A4UGR9 XIRP2_HUMAN Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) XIRP2 CMYA3 Homo sapiens (Human) actin filament organization [GO:0007015]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; positive regulation of protein localization [GO:1903829]; regulation of actin filament organization [GO:0110053]; ventricular septum development [GO:0003281] cell-cell junction [GO:0005911]; Z disc [GO:0030018] actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393] EIKGNVKR;FETQPLDQISEESHNIMPSIDHIQGGNVK;GNVNLTK;KELLKDDLETSLR;LPGSEEKNQGPSMIGRK;LSEHTQR;MLFETQPLYAIQDR;QQTYELRNDHQK;SAPKVVK;TVTDIQGGDVR;VEKRATYVHK 11 4 0.97499 -3.1303 13.1781 13.66 14.7053 12.4192 10.4452 0 5.98966 0 0 11.0785 11.0944 0 A4UGR9 XIRP2_HUMAN Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) XIRP2 CMYA3 Homo sapiens (Human) actin filament organization [GO:0007015]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; positive regulation of protein localization [GO:1903829]; regulation of actin filament organization [GO:0110053]; ventricular septum development [GO:0003281] cell-cell junction [GO:0005911]; Z disc [GO:0030018] actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393] DVKPWHVETTEAAR;ENLNKNNNNNYVAVSYLNNCR;KTLPFEEELK;LSLGNYASLHGQIYCKPHFK;VEVQSEQLTVEEQIK 5 8.5 0.91553 -0.39661 0 0 10.1101 9.9212 0 10.9462 0 0 0 9.89136 0 11.5309 A5D6W6 FITM1_HUMAN Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1) FITM1 FIT1 Homo sapiens (Human) lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890] endoplasmic reticulum membrane [GO:0005789] coenzyme A diphosphatase activity [GO:0010945]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129] AEEAAVFAK 1 9.4 0.91515 -0.37858 0 0 0 0 0 0 11.2325 0 0 0 0 0 A5D8T8 CL18A_HUMAN C-type lectin domain family 18 member A (Mannose receptor-like protein 2) CLEC18A MRLP2 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] polysaccharide binding [GO:0030247] GAASAGK 1 6.6 0.64775 0.17077 0 7.0227 9.27912 0 0 7.88013 0 0 10.7528 11.9849 0 0 A5D8V7 ODAD3_HUMAN Outer dynein arm-docking complex subunit 3 (Coiled-coil domain-containing protein 151) ODAD3 CCDC151 Homo sapiens (Human) brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; multicellular organism growth [GO:0035264]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228] FLAQGDTFAQLETLK;SENEQTLVRLKQEK 2 4.9 0.98011 -2.0093 0 0 0 0 0 0 0 0 0 11.8666 12.0705 0 A5D8W1 CFA69_HUMAN Cilia- and flagella-associated protein 69 CFAP69 C7orf63 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; olfactory behavior [GO:0042048]; positive regulation of fertilization [GO:1905516]; positive regulation of flagellated sperm motility [GO:1902093]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sperm axoneme assembly [GO:0007288] cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; sperm midpiece [GO:0097225] ELANKSWEDFLAR;GFSHYDRQLR;LDFENLPGLSAEDFVTLCIIHRYLDFK;SLQEKAIEASR;TMVQSMTLLENQLVEK;YSLRLLRAVVYLEDETVNK 6 10.2 0.97988 -2.0032 7.67539 0 10.4521 0 0 0 0 12.2223 12.7188 7.70584 8.71325 7.59014 A5PKW4 PSD1_HUMAN PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) PSD EFA6 EFA6A KIAA2011 PSD1 TYL Homo sapiens (Human) neuron projection development [GO:0031175]; regulation of ARF protein signal transduction [GO:0032012]; signal transduction [GO:0007165] "cleavage furrow [GO:0032154]; dendritic spine [GO:0043197]; postsynaptic density, intracellular component [GO:0099092]; ruffle membrane [GO:0032587]" guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] GGSALPGSR;SLSELADPNPK 2 2 0.96353 -1.1123 0 12.2575 0 0 0 0 0 0 0 0 0 0 A5PL33 KRBA1_HUMAN Protein KRBA1 KRBA1 KIAA1862 Homo sapiens (Human) AEPRNWTADKEGLR;ELPEAQDR 2 2.1 0.95237 -0.71884 11.7485 0 0 0 0 0 0 0 0 0 0 0 A5PLK6 RGSL_HUMAN Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) membrane [GO:0016020] AKSHLHMEAPFETK;APKIDFK;ATRSYLQYR;AYNENDVILMR;FTLLRGIEWLQPQR;ISDDYKIYCEKAPK;MAIQKISDDYK;REILSHMQK 8 7.4 0.97472 -3.7194 0 12.247 11.5951 0 0 0 10.6952 10.143 0 15.0749 14.9066 10.1445 A5PLK6 RGSL_HUMAN Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) membrane [GO:0016020] APKIDFK;AYNENDVILMR;ISDDYKIYCEKAPK;MAIQKISDDYK;VLFLEGNPLLLTV 5 10 0.80895 0.010296 0 3.11859 0 0 0 0 0 0 0 0 0 0 A5PLL1 AN34B_HUMAN Ankyrin repeat domain-containing protein 34B ANKRD34B Homo sapiens (Human) nucleus [GO:0005634]; pi-body [GO:0071546] DEGMEISSEGNSLIKAVHQSR;ICSLLSCGQK;KPALAPK 3 7.4 0.93338 -0.51339 0 0 0 9.38666 9.80373 9.61618 0 0 0 10.3399 0 0 A5PLL7 PDES1_HUMAN Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189) PEDS1 KUA PDES TMEM189 Homo sapiens (Human) ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] plasmanylethanolamine desaturase activity [GO:0050207] AFIRPFREHHIDPTAITR 1 6.7 0.82652 -0.020236 0 12.6282 0 0 0 0 0 0 0 0 0 0 A5PLN7 F149A_HUMAN Protein FAM149A FAM149A MST119 Homo sapiens (Human) DSLPTHFTRNVQK 1 1.7 0.9468 -0.66073 0 0 0 0 9.44269 0 0 0 0 0 0 0 A5PLN9 TPC13_HUMAN Trafficking protein particle complex subunit 13 TRAPPC13 C5orf44 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] NEFAEKAGIIK;QYLYCLKPK 2 4.8 0.93311 -0.49538 0 0 0 0 0 0 0 0 11.3411 9.6185 0 0 A5X5Y0 5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E) HTR3E Homo sapiens (Human) inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EVPSPGSHR 1 1.9 0.93338 -0.51462 0 0 0 0 0 0 0 0 11.3505 0 0 0 A5YKK6 CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) CNOT1 CDC39 KIAA1007 NOT1 AD-005 Homo sapiens (Human) "miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]" CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778] armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] AAANFSDR;AGPEMDKR;AYGSPWCNK;CPVVLAPLLYPEKR;EIDDEANSYFQR;ELNPSLNFK;YNVEAVELLIR 7 3 0.97431 -2.4513 0 0 0 9.63608 0 0 0 0 0 7.34279 0 9.98285 A5YKK6 CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) CNOT1 CDC39 KIAA1007 NOT1 AD-005 Homo sapiens (Human) "miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]" CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778] armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] AAANFSDR;CPVVLAPLLYPEKR;EIDDEANSYFQR;ELNPSLNFK;VSWLFPWYRYK 5 3.5 0.98017 -1.5718 0 12.8162 0 0 0 0 0 0 0 0 0 0 A5YM72 CRNS1_HUMAN Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) carnosine biosynthetic process [GO:0035499]; L-histidine catabolic process [GO:0006548] cytosol [GO:0005829] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carnosine synthase activity [GO:0047730]; homocarnosine synthase activity [GO:0102102]; metal ion binding [GO:0046872] AELGAVVDTVLALLEK;LSGWRWRGR 2 3 0.93339 -0.51363 0 0 0 0 0 0 0 3.20444 0 0 9.50516 0 A6BM72 MEG11_HUMAN Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] basolateral plasma membrane [GO:0016323] TVGAYASVR 1 1 0.93681 -0.52476 0 0 9.5856 0 0 0 0 0 0 0 0 0 A6H8M9 CDHR4_HUMAN Cadherin-related family member 4 (Cadherin-like protein 29) CDHR4 CDH29 UNQ9392/PRO34300 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] TPRSAGKPR 1 4.5 0.98009 -1.5695 0 0 0 0 10.2748 10.2497 0 0 0 0 0 0 A6H8Y1 BDP1_HUMAN Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) BDP1 KIAA1241 KIAA1689 TFNR Homo sapiens (Human) RNA polymerase III preinitiation complex assembly [GO:0070898] nucleoplasm [GO:0005654]; transcription factor TFIIIB complex [GO:0000126] TFIIIC-class transcription factor complex binding [GO:0001156] ALCEVNNAEGSCIEER;DKMNTLDILR;EEPVLEKVTTDQSKEGKPEDHLLQK;EKKSTKPR;ESVIQTARQVR;ETTESEKYIYEKK;GRLQKPKPNAGKAAER;LKRSNPFNESQEK;LNQVPILRTR;LQRPRPNIR;NLGPVTTAENK;RARLSVKPNVRPGVGAR;RFQCRLDK;SHIPSSLDNVNHK;TILPKDETEKK;VLAEEEK 16 7.5 0.97866 -10.255 8.70964 7.85941 0 0 12.847 10.6304 9.61162 10.445 0 11.459 9.83755 0 A6NC05 YD286_HUMAN Glutaredoxin-like protein C5orf63 C5orf63 Homo sapiens (Human) DPCPLCDEAK;EVLKPYENRQPYKDQK 2 18.8 0.057627 0.44624 0 0 0 0 6.83656 0 4.56273 0 0 0 0 0 A6NC57 ANR62_HUMAN Ankyrin repeat domain-containing protein 62 ANKRD62 Homo sapiens (Human) EVRGSFLAACR;SIEDQKCYCER;TSNEKSK 3 3.2 0.97869 -2.0563 0 0 8.20276 0 10.1217 0 0 0 5.99655 0 0 0 A6NC78 GOG8I_HUMAN Putative golgin subfamily A member 8I (Golgin subfamily A member 8I pseudogene) GOLGA8IP GOLGA8I GOLGA9P Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] GQEERIR;VQLTQLKESFQQLQLER 2 3.8 0.98095 -1.6257 4.0009 0 0 0 0 0 0 9.64126 0 0 0 0 A6NC86 PINLY_HUMAN phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein PINLYP Homo sapiens (Human) extracellular region [GO:0005576] phospholipase inhibitor activity [GO:0004859] CMGPMTHCTGK 1 5.4 0.27825 0.25399 0 0 0 0 0 0 0 0 0 6.9357 0 0 A6NC97 ARB2P_HUMAN Putative protein ARB2BP (Protein FAM172BP) ARB2BP FAM172B FAM172BP Homo sapiens (Human) regulatory ncRNA-mediated heterochromatin formation [GO:0031048] membrane [GO:0016020]; nucleus [GO:0005634] DIAFIVHGYGGLVFMDLLVR;RWEVMSK;YILAPSSSLQSIFKYFKK 3 12.4 0.92841 -0.47283 0 0 0 0 3.81168 0 0 0 9.31288 0 0 0 A6NC98 CC88B_HUMAN Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) CCDC88B BRLZ Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017] AEPQLVETQNVR;AQMLLAELSRER;CRERLQAAEAYK;GLEEELR;QEFLREKESQHQR;SLESRDHLHR;SQLEEERVLSGVLEASK;TLERENRELR 8 6.3 0.98108 -1.7295 0 0 0 3.73042 0 0 0 0 11.4704 0 5.89042 6.3436 A6NC98 CC88B_HUMAN Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) CCDC88B BRLZ Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017] AAGGCPR;ELDSLRHQVDQLAEENVELELELQR;GPCGKELDSLR;QEFLREKESQHQR;TLERENRELR 5 9.7 0.95358 -0.77683 8.60777 0 0 0 0 0 9.27298 0 0 0 7.08044 0 A6NC98 CC88B_HUMAN Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) CCDC88B BRLZ Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017] AEPQLVETQNVR;AQMLLAELSRER;GLEEELR;QEFLREKESQHQR;SLESRDHLHR;SSGSQGPQGESLDKEAWALR;TPLRPCR;WSWDECVDR 8 12.9 0.97461 -3.6635 0 12.2562 12.2511 0 0 6.54278 4.09195 0 0 8.99859 0 0 A6NCF5 KLH33_HUMAN Kelch-like protein 33 KLHL33 Homo sapiens (Human) FGRMSTR 1 1.3 0.90429 -0.26893 0 0 0 0 0 0 0 0 0 7.67172 0 0 A6NCF6 MA13P_HUMAN Putative MAGE domain-containing protein MAGEA13P MAGEA13P Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] VSASGTPGTPQSSQR 1 4.4 0.78515 0.029468 0 0 0 0 0 0 0 10.7909 0 0 0 0 A6NCI4 VWA3A_HUMAN von Willebrand factor A domain-containing protein 3A VWA3A Homo sapiens (Human) extracellular region [GO:0005576] AAVEFLR;ALNYSQKCAFLMASLKNHSGK;HDAPLTIEFPNLDK;LLLEEQLSNK;TVSSTIHEK;VLRRYVQR 6 5.8 0.97466 -2.4074 0 0 0 5.35826 7.00888 10.9585 0 0 0 0 9.1515 0 A6NCI4 VWA3A_HUMAN von Willebrand factor A domain-containing protein 3A VWA3A Homo sapiens (Human) extracellular region [GO:0005576] AAVEFLR;MEVYIRHLEK;VLRRYVQR 3 9.5 0.921 -0.44404 0 0 0 0 0 0 9.34687 0 0 0 0 0 A6NCI8 CB078_HUMAN Uncharacterized protein C2orf78 C2orf78 Homo sapiens (Human) EVVVGSATVSNSASVNK;TLGSSSNTQNR 2 3 0.94184 -0.60551 0 0 10.852 0 9.432 0 0 0 0 0 0 0 A6NCL1 GEMC1_HUMAN Geminin coiled-coil domain-containing protein 1 GMNC GEMC1 Homo sapiens (Human) cilium assembly [GO:0060271]; DNA replication [GO:0006260]; negative regulation of cell cycle [GO:0045786]; regulation of DNA-templated DNA replication initiation [GO:0030174] nucleus [GO:0005634] chromatin binding [GO:0003682] LLSSDEFSKAYGK 1 3.9 0.88781 -0.18467 0 0 0 0 0 0 10.6295 0 0 0 0 0 A6NCL2 LRCL1_HUMAN Leucine-rich colipase-like protein 1 LRCOL1 Homo sapiens (Human) digestion [GO:0007586]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576] enzyme activator activity [GO:0008047] CSHDSECQSSCCVR;KPNGDFCSSHQECHSQCCIQLR 2 22.6 0.2052 0.32768 0 0 0 5.12043 5.86728 0 0 0 2.46835 0 0 0 A6NCM1 IQCAL_HUMAN IQ and AAA domain-containing protein 1-like (IQ and AAA domain-containing protein 1 pseudogene 1) IQCA1L IQCA1P1 Homo sapiens (Human) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568] IQVDELMR;IREDGWHKFSQGQAAVTIQK;VARLLQPSVIWIGNAEK 3 5.5 0.98097 -1.7387 0 0 0 0 0 0 0 13.0178 0 0 0 0 A6NCQ9 RN222_HUMAN RING finger protein 222 RNF222 Homo sapiens (Human) membrane [GO:0016020] metal ion binding [GO:0046872] ALLLITLIAVVAVVAAILPWVLLVRK;RSLAELSEASLAPR;SRALLLITLIAVVAVVAAILPWVLLVRK;VDGQVQRTLVCPICRYVTFLSK 4 29.1 0.88302 -0.17835 10.1453 0 0 0 0 0 0 0 5.26574 4.66942 0 0 A6NCS4 NKX26_HUMAN Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F) NKX2-6 NKX2F Homo sapiens (Human) atrial cardiac muscle cell development [GO:0055014]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic heart tube development [GO:0035050]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; hypothalamus development [GO:0021854]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; pericardium development [GO:0060039]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue development [GO:0043586]; ventricular cardiac muscle cell development [GO:0055015] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVGNSGDSVRGGRSEQPK 1 6 0.85055 -0.078839 0 0 0 0 0 0 0 0 9.19007 0 0 0 A6NCS6 CB072_HUMAN Uncharacterized protein C2orf72 C2orf72 Homo sapiens (Human) AVFPPEPGAAKPGGAAAEGAGPGAARGAQR;EMLRDVRGR;GAQRAAR 3 14.2 0.8733 -0.11438 0 0 0 8.72288 8.71057 8.88999 0 11.0765 10.0276 0 0 0 A6ND36 FA83G_HUMAN Protein FAM83G (Protein associated with SMAD1) FAM83G PAWS1 Homo sapiens (Human) BMP signaling pathway [GO:0030509] cytosol [GO:0005829]; nucleus [GO:0005634] protein kinase binding [GO:0019901] YFLHMCERACMHLGHLK 1 2.1 0.91808 -0.43547 0 0 9.89257 0 0 0 0 0 0 0 0 0 A6NDA9 LRIT2_HUMAN "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Leucine-rich repeat-containing protein 22)" LRIT2 LRRC22 Homo sapiens (Human) membrane [GO:0016020] IPGNLSEEFKQVR;TLQCTSVSLGK;VLDLKRNK 3 5.8 0.95319 -0.77721 0 0 12.097 0 7.89227 7.5051 9.46928 0 0 0 8.3706 0 A6NDI0 TR49B_HUMAN Putative tripartite motif-containing protein 49B (RING finger protein 18B) TRIM49B RNF18B Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DSPFLVQCSECTK 1 2.9 0.80505 0.013954 0 0 0 0 9.13219 0 0 0 0 0 0 0 A6NDU8 RIMC1_HUMAN RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) RIMOC1 C5orf51 Homo sapiens (Human) mitophagy [GO:0000423] cytosol [GO:0005829]; nucleoplasm [GO:0005654] LVDEDFPEDSSSQKVK 1 5.4 0.81225 -0.01321 0 0 0 0 7.43663 7.02824 0 0 0 0 0 0 A6NDV4 TMM8B_HUMAN Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6) TMEM8B C9orf127 NGX6 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; regulation of mitotic cell cycle [GO:0007346] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] SLCGVGPRFVRCR 1 2.8 0.86799 -0.09159 7.84549 0 0 0 0 0 0 0 0 8.26256 0 0 A6NDX5 ZN840_HUMAN Putative zinc finger protein 840 (Zinc finger protein 840 pseudogene) ZNF840P C20orf157 ZNF840 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVTGDPCPACQPALATFR;KIHTGEKPYECGECGK;KYYTCNYCKK;LSDLTQHK;THTGEKPHKCDVCEK;YQSNFTKHQKTHSIGRPFTCNECGK 6 16.2 0.96513 -1.1502 0 11.6225 7.47013 0 3.53419 9.26296 0 0 0 0 8.28693 0 A6NDY0 EPAB2_HUMAN Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1) PABPN1L EPABP2 PABPNL1 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) binding [GO:0008143] GSVQAAVELDQSLFRGR 1 6.1 0.91689 -0.43016 0 0 0 0 0 0 0 0 0 0 6.76075 0 A6NDY0 EPAB2_HUMAN Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1) PABPN1L EPABP2 PABPNL1 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) binding [GO:0008143] GAGAWIR;NQLPWDQLHRPRGPSRTPR 2 9.7 0.92876 -0.46272 0 0 0 7.2484 0 0 0 0 0 0 0 0 A6NDY2 F90AA_HUMAN Putative protein FAM90A10 FAM90A10 FAM90A10P Homo sapiens (Human) GEKEERPR;NCGAFGHTARSTTCPMK 2 5.4 0.82835 -0.021626 0 0 0 0 4.1306 0 0 0 0 0 0 0 A6NE01 F186A_HUMAN Protein FAM186A FAM186A Homo sapiens (Human) ASLPTGQSIISRLSPSLR;CIKDSTIMRR;DNVSLKKGDFYQEDETDEYQSWK;EGKQEQQSQK;EPQNILSPLMLPNLEIPFSVK;GYEARNLHMMLSRLDDYGK;KEEQVGEKPIKQK;LLMEEDRTSDICK;SLSRVAKETSESTR;TFQSHFTK 10 6.3 0.98109 -1.6931 8.91115 0 11.2837 10.4948 7.43796 9.91328 10.4244 0 0 12.3946 3.16369 0 A6NE02 BTBDH_HUMAN BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) BTBD17 Homo sapiens (Human) negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615] extracellular region [GO:0005576]; plasma membrane [GO:0005886] LVVTPASSGGDAAGVSFQK 1 4 0.78147 0.033188 0 0 0 0 0 0 0 0 0 6.3722 0 0 A6NE52 WDR97_HUMAN WD repeat-containing protein 97 WDR97 KIAA1875 Homo sapiens (Human) LCAGRTLDGPIR;LYACSSLDCTVR;RLVLRGSALHPPPSPTGR;SRLCAGR;TLDGPIRTLKLPLPR 5 3.2 0.9777 -2.1668 0 0 0 8.72707 0 7.54882 8.78205 8.52974 9.0558 0 7.59798 10.3401 A6NEC2 PSAL_HUMAN Puromycin-sensitive aminopeptidase-like protein (EC 3.4.11.-) NPEPPSL1 Homo sapiens (Human) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] AIKATFDISLVVPK;ATFDISLVVPKDR;VALSNMNVIDR 3 5.6 0.95239 -0.72004 0 0 0 0 12.0982 0 0 0 0 0 0 0 A6NED2 RCCD1_HUMAN RCC1 domain-containing protein 1 RCCD1 Homo sapiens (Human) chromatin organization [GO:0006325] chromosome [GO:0005694]; cytosol [GO:0005829]; plasma membrane [GO:0005886] YGQLGHEDTTSLDRPRR 1 4.5 0.60966 0.17557 0 0 0 0 0 0 0 10.3851 0 0 0 0 A6NEL2 SWAHB_HUMAN Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) SOWAHB ANKRD56 Homo sapiens (Human) AKLSSSDEEYLDEGLLKR;RSSLAGR 2 3.2 0.36961 0.22693 0 0 9.45329 0 0 0 0 8.44261 0 0 0 0 A6NEN9 CX065_HUMAN Uncharacterized protein CXorf65 CXorf65 Homo sapiens (Human) IQCDALERR;IQMLKMK 2 8.7 0.98057 -1.5526 0 0 0 0 10.3371 9.05924 0 0 0 0 0 0 A6NEQ2 F181B_HUMAN Protein FAM181B FAM181B Homo sapiens (Human) AGGGGCGPSGPDVSLGDLEK 1 4.7 0.78274 0.025586 0 0 0 0 0 0 0 0 0 0 6.40538 0 A6NER0 TBC3F_HUMAN TBC1 domain family member 3F TBC1D3F TBC1D3E Homo sapiens (Human) plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GPMWSVLLNIEEMK;SKWVDMLGDWEKYK;VRSAFAAPSTDSDQGTPFRAR 3 8.9 0.78728 0.01739 0 0 0 0 7.45631 0 0 0 0 0 0 0 A6NES4 MRO2A_HUMAN Maestro heat-like repeat-containing protein family member 2A (HEAT repeat-containing protein 7B1) MROH2A HEATR7B1 Homo sapiens (Human) cytoplasm [GO:0005737] ALGFTLATGLEASK;AWEDKLIQFLR;EIPEMEGYMK;GLQEMVQLLEK;IAACNLAGIIMKQMSTHYLKK;IITSSVSGMTTEFWVR;ISATSKADIWR;LVAIASK;TVLNVLHDFEER;YFVTVWLRHYNPEVKLGVIK 10 7.9 0.97679 -2.1743 0 12.7541 10.49 0 0 0 11.4326 5.10459 0 7.24726 11.3706 0 A6NEY8 PRXD1_HUMAN Putative prolyl-tRNA synthetase associated domain-containing protein 1 (PrdX deacylase domain-containing protein 1) (Prolyl-tRNA synthetase associated domain-containing protein 1 pseudogene) PRORSD1P NCRNA00117 PRDXDD1P Homo sapiens (Human) aminoacyl-tRNA editing activity [GO:0002161] AGAELGAALEQR 1 7.1 0.89754 -0.23806 0 0 10.7353 0 0 0 0 0 0 0 0 0 A6NF34 ANTRL_HUMAN Anthrax toxin receptor-like ANTXRL Homo sapiens (Human) cell surface [GO:0009986]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] IVPDGHTFMQAGFR 1 2.2 0.89823 -0.23154 0 0 0 0 0 0 0 0 0 7.77624 0 0 A6NFA0 S31F3_HUMAN Protein SPATA31F3 (Protein FAM205C) SPATA31F3 FAM205C FAM205CP Homo sapiens (Human) membrane [GO:0016020] HEESILLSK;SCCRCHR 2 4.7 0.95546 -0.81405 0 0 0 6.21185 0 0 0 0 0 0 9.46667 0 A6NFA1 TIKI2_HUMAN "Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B)" TRABD2B HKAT TIKI2 Homo sapiens (Human) negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] organelle membrane [GO:0031090]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147] AGSLQASYTTEDLIK 1 2.9 0.78251 0.031599 0 11.0316 0 0 0 0 0 0 0 0 0 0 A6NFE2 SMCO2_HUMAN Single-pass membrane and coiled-coil domain-containing protein 2 SMCO2 C12orf70 Homo sapiens (Human) membrane [GO:0016020] EPFLNLEVEALLPS;LEDLCKNVELLSAKLR;LNYWNTK;MSLQMKMDCQEQQLTK 4 15.5 0.95577 -0.94208 0 0 0 4.85454 4.92125 0 0 7.01681 0 9.63835 0 0 A6NFF2 NP1L6_HUMAN Putative nucleosome assembly protein 1-like 6 NAP1L6P NAP1L6 Homo sapiens (Human) nucleosome assembly [GO:0006334] nucleus [GO:0005634] VYTLKKLQAK 1 9.3 0.77469 0.049784 0 0 0 0 0 0 0 0 0 0 0 4.76919 A6NFI3 ZN316_HUMAN Zinc finger protein 316 ZNF316 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" ADFQRHR;AEDGSECDPDQEEEEEEEEK 2 2.7 0.96388 -1.1841 5.81729 0 0 0 0 0 0 0 0 0 0 0 A6NFN3 RFOX3_HUMAN RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) (Neuronal nuclei antigen) (NeuN antigen) RBFOX3 Homo sapiens (Human) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] GSKGFGFVTFETSSDADR;GSKGFGFVTFETSSDADRAR;IEVNNATARVMTNK;IEVNNATARVMTNKK 4 11.2 0.41335 0.20283 0 8.77505 0 12.8427 0 0 0 0 11.5369 12.6389 0 0 A6NFN9 ANKUB_HUMAN Protein ANKUB1 (Ankyrin repeat and ubiquitin domain-containing 1) ANKUB1 C3orf16 Homo sapiens (Human) CGLPVSVYCLR;EFLMGCLLGQK;LDVWDGWKEFLMGCLLGQK;MWSTVSFPKISVPMR;SQFCGAR 5 10.4 0.96572 -1.2443 9.0321 7.20183 9.86702 5.16314 0 0 0 0 6.55099 0 0 0 A6NFQ2 TCAF2_HUMAN TRPM8 channel-associated factor 2 (TRP channel-associated factor 2) TCAF2 FAM115C FAM139A Homo sapiens (Human) negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314] cell junction [GO:0030054]; plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] AYSDKEAK;GAVPAPYYK 2 1.8 0.94501 -0.64403 0 0 0 0 0 8.81407 0 0 0 0 0 11.0385 A6NFT4 CFA73_HUMAN Cilia- and flagella-associated protein 73 (Coiled-coil domain-containing protein 42B) CFAP73 CCDC42B Homo sapiens (Human) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; spermatid development [GO:0007286] axonemal doublet microtubule [GO:0097545]; motile cilium [GO:0031514] dynein complex binding [GO:0070840] AQLQERLEAAR;TLLLGRSR 2 6.2 0.93546 -0.52063 0 0 0 6.19283 0 0 0 0 0 0 0 11.1765 A6NFU8 PGPIL_HUMAN Pyroglutamyl-peptidase 1-like protein (EC 3.4.19.-) PGPEP1L Homo sapiens (Human) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] VAVEGVDVIFSRDAGR 1 11.3 0.91569 -0.36675 12.4019 0 0 0 0 0 0 0 0 0 0 0 A6NFY4 NEMP2_HUMAN Nuclear envelope integral membrane protein 2 NEMP2 TMEM194B Homo sapiens (Human) nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] IFNYMIHVNRNIMDFK 1 3.8 0.81252 -0.013641 0 0 0 0 0 0 0 0 0 0 9.41015 0 A6NFZ4 FA24A_HUMAN Protein FAM24A FAM24A Homo sapiens (Human) extracellular region [GO:0005576] AKMFDLRTK 1 8.6 0.88245 -0.17073 0 0 0 0 0 0 0 0 0 0 4.17201 0 A6NGB9 WIPF3_HUMAN WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) WIPF3 CR16 Homo sapiens (Human) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell differentiation [GO:0030154]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]" cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] IYPSKIPR;KVTQINDRSAPQIESSK;RADPKGR 3 6.6 0.97451 -3.8628 0 0 0 3.63587 0 0 0 0 9.81163 0 0 11.5892 A6NGE4 DC8L1_HUMAN DDB1- and CUL4-associated factor 8-like protein 1 (WD repeat-containing protein 42B) DCAF8L1 WDR42B Homo sapiens (Human) Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DEDNLNYTDSFDNR;EEEEEEMEEEGEEEEQPR;ENNGVLKK 3 6.7 0.9666 -1.2643 0 0 0 0 0 0 0 11.3526 0 0 0 0 A6NGG3 CI092_HUMAN Putative uncharacterized protein encoded by LINC03041 (Long intergenic non-protein coding RNA 3041) LINC03041 C9orf92 Homo sapiens (Human) CSLNIYYVRNTTQGTAPACVGK;NLKPMNGAWPPARREMAR 2 37 0.86991 -0.10095 0 0 12.1203 0 0 0 0 0 11.3198 0 0 0 A6NGG8 PCARE_HUMAN Photoreceptor cilium actin regulator PCARE C2orf71 Homo sapiens (Human) photoreceptor cell outer segment organization [GO:0035845]; protein localization to photoreceptor outer segment [GO:1903546]; visual perception [GO:0007601] cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] AIAWHHSGPPSGQNR;LRSLQAQEMILK;NFSILPSQDK;SILQKCNPHPEDEQGK;TVVPPRPSTVSGSRRAPER;VQRDLSQK 6 6.2 0.97391 -3.0213 10.5872 0 10.8963 0 11.136 0 9.9158 0 9.13681 0 8.17473 0 A6NGH8 ANR61_HUMAN Ankyrin repeat domain-containing protein 61 ANKRD61 Homo sapiens (Human) nucleoplasm [GO:0005654] EDCTTIEVLLR;ILCAHGAQVNTQGEISNK;LLLTHGAK 3 8.9 0.75636 0.074148 0 11.43 0 0 0 9.7607 5.91311 0 0 0 0 0 A6NGR9 MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 MROH6 C8orf73 Homo sapiens (Human) cytoplasm [GO:0005737] APVRLLSAELGPR;LQSDPKPAVAAAAHVSAQQVAMLAR;LVGAALGALRRLLLRPR 3 7.6 0.96126 -1.0623 8.51017 0 0 10.2976 0 0 0 0 0 0 0 0 A6NGU7 CX028_HUMAN Putative uncharacterized protein encoded by LINC01546 LINC01546 CXorf28 Homo sapiens (Human) ATQQWILKNK;ATQQWILKNKTQEGSHLQTK 2 22.5 0.87399 -0.11357 0 0 8.1316 0 0 0 0 0 0 8.48856 0 0 A6NGY5 O51F1_HUMAN Olfactory receptor 51F1 OR51F1 OR51F1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIVLILPLLLLLKPLYFCR 1 6 0.66861 0.16878 0 4.69599 0 0 0 0 0 0 0 0 0 0 A6NH00 OR2T8_HUMAN Olfactory receptor 2T8 OR2T8 OR2T8P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YAAVCHPLRYPTLMSWQLCLR 1 6.7 0.82567 -0.021489 7.77703 0 0 0 0 0 0 0 0 4.88401 0 0 A6NH11 GLTD2_HUMAN Glycolipid transfer protein domain-containing protein 2 GLTPD2 Homo sapiens (Human) ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009] cytosol [GO:0005829] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388] LLELACPGATEAEAR 1 5.2 0.87643 -0.12344 0 0 0 0 8.71593 0 0 0 0 0 0 0 A6NH13 DAS1_HUMAN Putative uncharacterized protein DNAJC9-AS1 (DNAJC9 antisense RNA 1) (DNAJC9 antisense gene protein 1) DNAJC9-AS1 C10orf103 Homo sapiens (Human) KMRCGESGAGPDPR 1 9.5 0.86614 -0.090523 0 3.0915 0 0 0 0 0 0 0 0 0 0 A6NH21 SERC4_HUMAN Serine incorporator 4 SERINC4 Homo sapiens (Human) phospholipid biosynthetic process [GO:0008654] membrane [GO:0016020] GSWATFWVK;SPFCQVCCCGPAPCASCCHSR;TVVERVWGKTHR 3 8.1 0.96645 -1.2813 4.96023 0 0 0 0 0 8.05815 0 11.2847 0 0 0 A6NH52 TV23A_HUMAN Golgi apparatus membrane protein TVP23 homolog A TVP23A FAM18A Homo sapiens (Human) protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] LLASVILLPWPPKVLGLK 1 9.6 0.83196 -0.026454 0 0 0 10.4196 10.18 0 0 0 0 0 0 10.7745 A6NHG4 DDTL_HUMAN D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein) DDTL Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] lyase activity [GO:0016829]; phenylpyruvate tautomerase activity [GO:0050178] ELALGQDR;FPTVLSTSPAAHGGPR;VPAGLEK 3 23.1 0.95489 -0.95639 0 0 0 0 0 0 0 0 0 7.9151 8.89342 0 A6NHG9 O5H14_HUMAN Olfactory receptor 5H14 OR5H14 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IPLFLAFLVIYLITIMGNLGLIAVIWK;QVIASFTKMFK 2 12.3 0.96445 -1.197 0 3.74136 0 0 0 0 0 0 0 0 0 0 A6NHJ4 ZN860_HUMAN Zinc finger protein 860 ZNF860 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;LTGSTDR;TFRHNSALVIHKAIHTGEKPYK 3 6.2 0.55942 0.18276 0 0 0 0 0 0 0 0 0 8.77788 0 0 A6NHL2 TBAL3_HUMAN Tubulin alpha chain-like 3 (EC 3.6.5.-) TUBAL3 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] EDAANNYAR;FDLMYAK;TGQHRSLFHPEQLLSGK;YMACCLLYR 4 9.4 0.82355 -0.018096 0 0 0 0 0 0 0 8.21208 0 0 0 0 A6NHQ2 FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase) FBLL1 Homo sapiens (Human) blastocyst hatching [GO:0001835]; box C/D sno(s)RNA 3'-end processing [GO:0000494]; rRNA methylation [GO:0031167] box C/D methylation guide snoRNP complex [GO:0031428]; Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649] GGFGARARGFGGGGR;GGGGGGR;TNIIPVLEDAR 3 9.9 0.78534 0.029292 0 0 10.9498 9.26388 0 0 0 0 0 0 7.39481 0 A6NHQ4 EPOP_HUMAN Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) EPOP C17orf96 PRR28 Homo sapiens (Human) neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]; transcription elongation-coupled chromatin remodeling [GO:0140673] chromosome [GO:0005694]; elongin complex [GO:0070449]; ESC/E(Z) complex [GO:0035098] chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877] GPERPPAK;GPQAPLRPGGWAPDGLK 2 6.6 0.93012 -0.48003 0 10.4769 0 0 0 0 0 0 0 0 0 0 A6NHR8 FA47D_HUMAN Putative protein FAM47D FAM47DP Homo sapiens (Human) APVSHHFLEPPK;DWDRKLQMAPNSYTAQCVK;ESMDSFHYGCPSPEDMLICR;EWVSELQYRIK;YGVWYLKPK 5 17.9 0.98188 -1.5816 0 0 0 0 0 10.8357 0 0 5.20516 8.9166 0 11.1895 A6NHR9 SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) SMCHD1 KIAA0650 Homo sapiens (Human) chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nose development [GO:0043584]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034] Barr body [GO:0001740]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; protein homodimerization activity [GO:0042803] EIISHISQHGGKWPYWFK;FTLFKGVITRPDLPSKK;GEHTLQVK;GVTAKGPVNSCQGK;IEILNKKGEAMQK;ILNGQEQRMK;KEVVKITHCPTLLTR;LGMTPIRK;LLPSSHVAR;LLVELKVILHSSSGNK;LTFMDLELK;SLFEASQQLLNEMK 12 7.5 0.97621 -5.3208 8.80229 0 0 11.3829 6.96428 10.417 0 12.9782 8.74049 0 0 9.67918 A6NHS7 MANS4_HUMAN MANSC domain-containing protein 4 MANSC4 Homo sapiens (Human) epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198] plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] TISPFFEPIDTK 1 3.5 0.88832 -0.20093 0 0 0 0 0 0 11.1121 0 0 0 0 0 A6NHX0 CAST2_HUMAN Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) CASTOR2 GATSL1 GATSL2 Homo sapiens (Human) cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262] cytosol [GO:0005829] identical protein binding [GO:0042802] ELHILEHR 1 2.4 0.9172 -0.42856 0 0 0 0 0 0 11.1211 0 0 0 0 0 A6NHY2 AKD1B_HUMAN Ankyrin repeat and death domain-containing protein 1B ANKDD1B Homo sapiens (Human) signal transduction [GO:0007165] IPKREGLGEEDTAVAGHELLLPNER;QLYEELVHAGFPKLAEK;SFQNAAKSNNLDLMEKLFEK 3 11.7 0.91562 -0.34634 0 0 4.85335 0 0 7.73505 0 0 0 7.03661 0 0 A6NI03 TR64B_HUMAN Putative tripartite motif-containing protein 64B TRIM64B Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] MTQHLERMKDMYR 1 2.9 0.86537 -0.092073 0 0 0 0 0 0 0 9.56866 0 0 0 0 A6NI28 RHG42_HUMAN Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) ARHGAP42 GRAF3 TMEM133 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] HLNLSAKK;IGGVNSK;LPEKNREMLDILIK;SDDQNYR 4 4.1 0.91681 -0.42977 11.0546 14.3264 0 0 0 0 0 0 0 0 4.91543 0 A6NI56 CC154_HUMAN Coiled-coil domain-containing protein 154 CCDC154 C16orf29 Homo sapiens (Human) bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; odontogenesis of dentin-containing tooth [GO:0042475]; sensory perception of sound [GO:0007605]; tooth eruption [GO:0044691] early endosome [GO:0005769] FLKREAK;GELESRWEK;KIAEMQGKLATFQNQIMK;RGAEQEAGLRLAK;TPLGSWKALPSLVRPRVFIK 5 10 0.97857 -1.9417 0 9.53459 0 0 0 0 0 0 9.03565 0 0 6.93923 A6NIJ9 O6C70_HUMAN Olfactory receptor 6C70 OR6C70 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NFSFLEISFTTACIPR 1 5.1 0.60055 0.17744 0 0 0 0 0 0 0 0 0 9.98328 0 0 A6NIK2 LR10B_HUMAN Leucine-rich repeat-containing protein 10B LRRC10B Homo sapiens (Human) ALEAAPGLGT 1 3.4 0.94093 -0.5921 0 0 12.4784 0 0 0 0 0 0 0 0 0 A6NIV6 LRIQ4_HUMAN Leucine-rich repeat and IQ domain-containing protein 4 (Leucine-rich repeat-containing protein 64) LRRIQ4 LRRC64 Homo sapiens (Human) cytoplasm [GO:0005737] EVCAEGNEAIWKYLK;VPRLICR 2 3.9 0.97864 -1.9846 0 0 0 0 0 0 0 0 10.5641 0 0 11.5022 A6NJ88 SGE2P_HUMAN Putative SAGE1-like protein (Sarcoma antigen 2 pseudogene) SAGE2P Homo sapiens (Human) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] DAVVNLNVHGEK;EIDSHCHLR 2 3.4 0.89578 -0.23662 0 12.0418 0 0 0 0 0 0 0 0 0 0 A6NJG2 SWAHD_HUMAN Ankyrin repeat domain-containing protein SOWAHD (Ankyrin repeat domain-containing protein 58) (Protein sosondowah homolog D) SOWAHD ANKRD58 Homo sapiens (Human) CAPQPRPSR;YEVLRELLEAEPELLLR 2 8.3 0.91566 -0.33924 0 12.6936 0 8.70058 6.41483 0 0 0 0 0 0 6.73701 A6NJI9 LRC72_HUMAN Leucine-rich repeat-containing protein 72 LRRC72 Homo sapiens (Human) ASETALQSSRR;SMKRSVMTLTSMNWDTVPTR 2 10.8 0.22312 0.30983 0 0 0 10.1734 0 0 0 0 0 0 10.2926 0 A6NJR5 SPDL3_HUMAN Putative speedy protein-like protein 3 Homo sapiens (Human) protein kinase binding [GO:0019901] FQFFCSMSGRAWVSR 1 5.2 0.91513 -0.43423 0 0 0 0 0 0 0 0 3.95819 0 0 0 A6NJT0 UNC4_HUMAN Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) UNCX UNCX4.1 Homo sapiens (Human) cartilage condensation [GO:0001502]; common myeloid progenitor cell proliferation [GO:0035726]; dorsal spinal cord development [GO:0021516]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; regulation of cell differentiation [GO:0045595]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" ELEKMEK;LLKSQGR 2 2.6 0.95513 -0.9373 0 0 0 0 0 0 0 0 0 0 3.60336 10.9076 A6NK02 TRI75_HUMAN Tripartite motif-containing protein 75 TRIM75 TRIM75P Homo sapiens (Human) female meiosis I [GO:0007144]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; spindle [GO:0005819] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] SEWAIGICKDSLPTKAR 1 3.6 0.86285 -0.083162 0 0 4.66568 7.12794 0 0 0 0 0 0 0 0 A6NK53 ZN233_HUMAN Zinc finger protein 233 ZNF233 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] EPQNYQSR 1 1.2 0.93678 -0.56299 0 0 0 0 0 0 0 0 0 0 10.22 0 A6NK58 LIPT2_HUMAN "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Lipoyltransferase 2) (EC 2.3.1.181) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)" LIPT2 Homo sapiens (Human) positive regulation of oxygen metabolic process [GO:2000376]; protein lipoylation [GO:0009249] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ligase activity [GO:0016874]; lipoyl(octanoyl) transferase activity [GO:0033819] ALGAEVR 1 3 0.92887 -0.46062 0 0 0 10.2909 0 0 0 0 0 0 0 0 A6NK75 ZNF98_HUMAN Zinc finger protein 98 (Zinc finger protein 739) (Zinc finger protein F7175) ZNF98 ZNF739 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFKQSSTLTTHKR;AFSRFSHLTTHK;MPGPLGSLEMGVLTFR 3 7.2 0.61412 0.17426 0 0 0 0 0 0 0 0 0 7.35297 0 0 A6NK89 RASFA_HUMAN Ras association domain-containing protein 10 RASSF10 Homo sapiens (Human) nervous system development [GO:0007399]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922] LSAEIQEELNQRWMR;MDPSEKKISVWICQEEK;QEELAAREEPLEPDGGPDGELLLEQER 3 11.6 0.91027 -0.29015 0 0 9.27009 0 0 0 0 0 0 7.73992 0 10.5649 A6NKB5 PCX2_HUMAN Pecanex-like protein 2 (Pecanex homolog protein 2) PCNX2 KIAA0435 PCNXL2 Homo sapiens (Human) membrane [GO:0016020] EQFYKFIIFPGK;FNREQFYK;GVILLEDHPIAPVSSTSPGIK;ILIRYYIK;NLSTPPLR;SLQPFAKWHYIER 6 3 0.97857 -1.9217 0 0 0 0 7.40139 5.16237 11.8986 9.42061 0 0 0 0 A6NKB5 PCX2_HUMAN Pecanex-like protein 2 (Pecanex homolog protein 2) PCNX2 KIAA0435 PCNXL2 Homo sapiens (Human) membrane [GO:0016020] DYLIGKIMNSHKDFFTSEK;EQFYKFIIFPGK;FNREQFYK 3 11.9 0.95817 -1.0137 0 0 0 8.25998 0 0 0 0 0 0 0 0 A6NKD9 CC85C_HUMAN Coiled-coil domain-containing protein 85C CCDC85C Homo sapiens (Human) cerebral cortex development [GO:0021987] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; bicellular tight junction [GO:0005923] EMCNVVWR;FGRHAAGAVWHEVARSQQK;LGDAASSKPSIRQHLSGNQFK 3 11.5 0.92871 -0.46192 0 0 0 0 0 6.91181 0 11.116 0 0 0 0 A6NKF1 SAC31_HUMAN SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1) SAC3D1 SHD1 Homo sapiens (Human) cell division [GO:0051301]; centrosome duplication [GO:0051298]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819] GAGPHPR 1 1.7 0.68578 0.16329 0 0 11.3538 8.51112 0 0 0 0 0 0 0 0 A6NKF2 ARI3C_HUMAN AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C) ARID3C Homo sapiens (Human) macrophage differentiation [GO:0030225]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GTPVNRVPIMAK;KEFLDDLFSFMQK 2 6.1 0.81155 -0.014399 9.51025 0 0 9.45105 0 7.50985 0 0 0 8.26599 0 0 A6NKL6 T200C_HUMAN Transmembrane protein 200C (Transmembrane protein TTMA) (Two transmembrane domain-containing family member A) TMEM200C TTMA Homo sapiens (Human) membrane [GO:0016020] DSGSSQSDDPSSSNK;GAEGSMR;GARREPEEPEGAVAAR;IFSGYLHSDKLK 4 8.1 0.97303 -2.5822 0 0 2.76165 9.93075 0 0 5.71161 0 0 6.0826 0 0 A6NKP2 D42E2_HUMAN Putative short-chain dehydrogenase/reductase family 42E member 2 (EC 1.1.1.-) SDR42E2 Homo sapiens (Human) steroid biosynthetic process [GO:0006694] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" FIQADVRDEEALYR;GSTARTLLRLLLR 2 6.4 0.9145 -0.38033 0 5.61956 5.00378 0 0 0 0 0 0 0 3.15677 0 A6NKT7 RGPD3_HUMAN RanBP2-like and GRIP domain-containing protein 3 RGPD3 RGP3 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] AVVSPPK;DLVLKIAELLCK;DVGQWKER;EMDPRAHR;EPPLWYAEFTKEELVQK;EYIGRSVHYWK;GEAGQNLLEMMACDR;KCELSKNSDIEQSSDSK;LRLLVQHEINTLR;QKSWWDAVCTLIHR;QLCTERQKSWWDAVCTLIHR;VLPLLKIIK;YDVGAIR;YSLSPSKSYK 14 8.8 0.91566 -0.43094 0 11.3133 0 0 0 0 0 0 0 0 0 0 A6NKU9 SPDE3_HUMAN Speedy protein E3 SPDYE3 Homo sapiens (Human) protein kinase binding [GO:0019901] VSLVLPEYYEAFNRLLAPGVDPSPPRR 1 19.7 0.69414 0.16215 0 0 0 0 0 4.66078 0 0 0 0 0 0 A6NKX4 S22AV_HUMAN Putative solute carrier family 22 member 31 SLC22A31 Homo sapiens (Human) monoatomic ion transport [GO:0006811] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AAGGFGR;FGRRAVFVASLVLTTGLGASEALAASFPTLLVLR;GLPQSLQDADRLR 3 9.7 0.95498 -0.90208 0 0 9.76663 0 0 0 8.10318 0 0 8.13227 0 9.61408 A6NL46 YF016_HUMAN Putative UPF0607 protein ENSP00000332738 Homo sapiens (Human) AAGHRPR;LPCLSPEALLVGK;VLSRTSK 3 7.9 0.81519 -0.0032372 0 0 0 9.3753 9.04169 0 9.84279 0 0 0 0 0 A6NL88 SHSA7_HUMAN Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like) SHISA7 Homo sapiens (Human) gamma-aminobutyric acid receptor clustering [GO:0097112]; gamma-aminobutyric acid signaling pathway [GO:0007214]; memory [GO:0007613]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of GABA-A receptor activity [GO:0106040] dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] GABA receptor binding [GO:0050811] TGGAGGR 1 1.3 0.69816 0.16173 0 0 0 7.63981 0 0 0 0 0 0 0 0 A6NLC5 CC070_HUMAN UPF0524 protein C3orf70 C3orf70 Homo sapiens (Human) circadian behavior [GO:0048512]; nervous system development [GO:0007399] FASVFQPPLPPDSPRYCMISDLFIDNYQVK;MSAAASPASER 2 16.4 0.8975 -0.25287 0 0 0 0 0 11.0187 0 0 0 0 8.26233 0 A6NLI5 TR64C_HUMAN Tripartite motif-containing protein 64C TRIM64C Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VIITIQYQK 1 2 0.93588 -0.5319 0 0 13.1988 0 0 0 0 14.3327 0 0 0 0 A6NLP5 TTC36_HUMAN Tetratricopeptide repeat protein 36 (TPR repeat protein 36) (HSP70-binding protein 21) TTC36 HBP21 Homo sapiens (Human) central nervous system neuron development [GO:0021954]; memory [GO:0007613]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein polyubiquitination [GO:1902915]; tyrosine metabolic process [GO:0006570]; visual learning [GO:0008542] LGSPFARRQLVLLNPYAALCNR 1 16.9 0.55054 0.18331 0 0 0 0 0 0 0 9.6834 0 0 0 0 A6NLX3 SPDE4_HUMAN Speedy protein E4 SPDYE4 Homo sapiens (Human) protein kinase binding [GO:0019901] LRYQLLCSMRWR;QDIFSFLYGK 2 9.3 0.94238 -0.62106 0 0 0 6.27516 0 0 0 0 0 0 0 10.4155 A6NM03 O2AG2_HUMAN Olfactory receptor 2AG2 OR2AG2 OR2AG2P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALADFLR 1 2.2 0.93725 -0.55344 0 0 0 0 9.61717 0 0 0 0 0 0 0 A6NM28 ZFP92_HUMAN Zinc finger protein 92 homolog (Zfp-92) ZFP92 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAQGLGQSSAAGPQGPK;GVSQLIHHQRSHSGERPFACRECGK 2 10.1 0.75906 0.071241 5.03773 0 0 4.30801 0 0 0 0 0 0 0 0 A6NM36 LRC30_HUMAN Leucine-rich repeat-containing protein 30 LRRC30 Homo sapiens (Human) intracellular signal transduction [GO:0035556] IVVLNLCGNR 1 3.3 0.89718 -0.23453 0 0 0 0 0 0 0 0 0 0 11.026 0 A6NM62 LRC53_HUMAN Leucine-rich repeat-containing protein 53 LRRC53 Homo sapiens (Human) plasma membrane [GO:0005886] DLSITSSHETQNR;FLMSEDNIDLSGLSTK;LSETNCDSK;SLSSLPK 4 3.6 0.95424 -0.90314 0 0 0 10.4933 0 0 0 13 8.66541 6.31139 0 0 A6NMB1 SIG16_HUMAN Sialic acid-binding Ig-like lectin 16 (Siglec-16) (Siglec-P16) SIGLEC16 SIGLECP16 Homo sapiens (Human) cell adhesion [GO:0007155]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691] FQLTGDPGKGSCSLVIRDAQR;VERGSRVR;VLEGQSLR 3 7.7 0.97398 -2.4191 0 0 0 9.3539 0 0 0 0 0 12.0745 0 0 A6NMD0 IFM10_HUMAN Interferon-induced transmembrane protein 10 (Dispanin subfamily A member 3) (DSPA3) IFITM10 Homo sapiens (Human) plasma membrane [GO:0005886] LLNDLNGAVEDAKTAR 1 7 0.91547 -0.43398 0 0 0 0 0 0 0 0 0 8.0332 0 0 A6NMK8 INY2B_HUMAN Protein INSYN2B (Inhibitory synaptic factor family member 2B) INSYN2B C5orf57 FAM196B Homo sapiens (Human) inhibitory postsynaptic potential [GO:0060080] postsynaptic density [GO:0014069] VRPVLLKR 1 1.5 0.8399 -0.043952 0 0 0 0 0 3.04194 0 0 0 0 0 0 A6NMS7 L37A1_HUMAN Leucine-rich repeat-containing protein 37A LRRC37A LRRC37A1 Homo sapiens (Human) membrane [GO:0016020] DLTHAISILESAK;KDPAQRWSLAEIIGITR;LPVSPKKLK;LTSPAPR;NNTKHTTAR;SSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVK 6 5.2 0.9725 -2.8201 0 0 0 9.1894 0 0 0 11.1173 10.9304 9.36232 4.92025 11.2939 A6NMT0 DBX1_HUMAN Homeobox protein DBX1 (Developing brain homeobox protein 1) DBX1 Homo sapiens (Human) cell differentiation in spinal cord [GO:0021515]; regulation of transcription by RNA polymerase II [GO:0006357]; ventral spinal cord interneuron specification [GO:0021521] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LGLKDSQVKIWFQNR;MFQKQKYISKPDR 2 8.2 0.82593 -0.019201 0 0 10.1051 0 0 0 12.1185 0 12.2026 0 0 0 A6NMX2 I4E1B_HUMAN Eukaryotic translation initiation factor 4E type 1B EIF4E1B Homo sapiens (Human) translational initiation [GO:0006413] eukaryotic translation initiation factor 4F complex [GO:0016281] RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743] LELHPLQNRWALWFFK 1 6.6 0.91638 -0.43326 0 0 0 0 0 0 0 4.81747 0 0 0 0 A6NMZ2 SNTAN_HUMAN Sentan (Protein S100-A1-like) (S100 calcium-binding protein A1-like) SNTN S100A1L Homo sapiens (Human) cilium [GO:0005929] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914] MGGCMHSTQDK 1 7.5 0.94432 -0.62356 0 0 8.79425 0 0 8.77854 0 0 0 0 0 0 A6NMZ7 CO6A6_HUMAN Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) cell adhesion [GO:0007155] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] DLSMFSQNMTHIIKDVIK;DSEDNVTKAAVNLRR;FEIYSENILNSLK;FFQDKKYLSR;FVKSFINSIRR;GAKGLASFSTCELIQYVRDR;LEQKSDELRK;RGPPGFK;TFMKNLVSK 9 5 0.97635 -4.6849 11.794 0 11.3269 4.49172 0 7.48655 0 7.39257 11.131 9.8801 6.34896 0 A6NN14 ZN729_HUMAN Zinc finger protein 729 ZNF729 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;AIHTGEKPYKCEECGKDFNNSSTLK;HKVIHTREK;KPYQCDECGK;LNQCRTATQR;RIHIRQNIYK;SFFMLSCLIR 7 8.2 0.97464 -3.4682 7.14598 0 0 0 9.90539 0 0 0 0 10.4549 0 0 A6NN73 GOG8C_HUMAN Golgin subfamily A member 8C GOLGA8CP GOLGA8C Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] LQEQQERLREQEER 1 2.3 0.56385 0.18273 0 0 0 0 0 0 0 0 7.73322 0 0 0 A6NN90 CB081_HUMAN Uncharacterized protein C2orf81 C2orf81 Homo sapiens (Human) LSAHHHRMRR 1 1.7 0.069079 0.42526 0 0 0 0 0 0 0 0 0 0 0 11.3454 A6NNA2 SRRM3_HUMAN Serine/arginine repetitive matrix protein 3 SRRM3 Homo sapiens (Human) nucleus [GO:0005634] mRNA binding [GO:0003729] AAGGAGR;GKESPSPR;RRLESECSCGSSSPLR;SRSYSPIR 4 6.5 0.97706 -1.4948 7.30943 7.192 0 0 0 0 0 0 11.5444 0 0 0 A6NNB3 IFM5_HUMAN Interferon-induced transmembrane protein 5 (Bone-restricted interferon-induced transmembrane protein-like protein) (BRIL) (Dispanin subfamily A member 1) (DSPA1) IFITM5 Homo sapiens (Human) bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; in utero embryonic development [GO:0001701]; regulation of bone mineralization [GO:0030500] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] LAKDSAAFFSTK 1 9.1 0.92415 -0.44837 0 0 0 0 0 0 0 0 0 0 6.98356 0 A6NNC1 P12LL_HUMAN Putative POM121-like protein 1-like Homo sapiens (Human) membrane [GO:0016020] SQTSRTRSCLK;VQENPDDQR 2 3.5 0.8955 -0.22867 0 0 0 0 0 0 0 0 0 0 10.5456 0 A6NND4 O2AT4_HUMAN Olfactory receptor 2AT4 (Olfactory receptor OR11-265) OR2AT4 Homo sapiens (Human) positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISSLEGR 1 2.2 0.9094 -0.3099 0 0 0 8.44099 0 0 0 0 0 0 0 0 A6NNF4 ZN726_HUMAN Zinc finger protein 726 ZNF726 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNRSSNLSTHK;SIYTTEK;SYKCKECGK 3 4.5 0.93303 -0.49608 0 0 1.81299 0 0 6.64717 0 0 0 0 8.04794 9.07839 A6NNM8 TTL13_HUMAN Tubulin polyglutamylase TTLL13 (EC 6.3.2.-) (Tubulin tyrosine ligase like 13) (Tubulin tyrosine ligase-like family member 13 pseudogene) (Tubulin--tyrosine ligase-like protein 13) TTLL13 TTLL13P Homo sapiens (Human) microtubule bundle formation [GO:0001578]; protein modification process [GO:0036211] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" DGAVGSK;LFQCYRQPR 2 2 0.97536 -1.4713 0 0 6.49726 0 10.1378 0 0 10.8501 0 0 0 0 A6NNP5 CC169_HUMAN Coiled-coil domain-containing protein 169 CCDC169 C13orf38 Homo sapiens (Human) MQENLVKTGRYNPAK;YYALKLEQESKAYQK 2 14 0.96508 -1.1212 0 0 0 0 0 0 10.1433 0 0 0 0 0 A6NNS2 DRS7C_HUMAN Dehydrogenase/reductase SDR family member 7C (EC 1.1.1.105) (Sarcoplasmic reticulum protein of 35 kDa) (Protein SRP-35) (Short-chain dehydrogenase/reductase family 32C member 2) (Protein SDR32C2) DHRS7C SDR32C2 Homo sapiens (Human) D-glucose import [GO:0046323]; intracellular calcium ion homeostasis [GO:0006874]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] longitudinal sarcoplasmic reticulum [GO:0014801]; sarcoplasmic reticulum membrane [GO:0033017] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" GPAHKISLELDK 1 3.9 0.88748 -0.18593 0 0 0 0 0 0 0 0 0 0 0 6.64038 A6NNT2 CP096_HUMAN Uncharacterized protein C16orf96 C16orf96 Homo sapiens (Human) IWGNQIEMMK;LEMNKVNK;LVHSDLDPLKKEMEEVWK;TLQAQIK 4 3.8 0.97301 -2.5696 0 12.7216 0 6.68018 0 0 0 0 0 0 0 11.2358 A6NNW6 ENO4_HUMAN Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO4 C10orf134 Homo sapiens (Human) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] ELQKLKQQAMEYYR;IFFASKVQEDK;IIEMPSPPK 3 5.4 0.98112 -1.7853 0 0 0 0 0 0 0 0 7.94796 0 10.8943 0 A6NNX1 RIAD1_HUMAN RIIa domain-containing protein 1 RIIAD1 C1orf230 Homo sapiens (Human) EVEWLISGFFREIFLK 1 17.4 0.88807 -0.20021 0 0 0 0 0 11.57 0 0 0 0 0 0 A6NP61 ZAR1L_HUMAN Protein ZAR1-like (Zygote arrest protein 1-like) ZAR1L Homo sapiens (Human) negative regulation of translation [GO:0017148]; oocyte maturation [GO:0001556]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232] metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730] QLCCKCQK;TLSSCSPWDGR 2 5.9 0.94045 -0.58344 0 0 0 0 0 0 2.35693 0 0 0 0 5.33696 A6PVC2 TTLL8_HUMAN Protein monoglycylase TTLL8 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 8) TTLL8 Homo sapiens (Human) axoneme assembly [GO:0035082]; flagellated sperm motility [GO:0030317]; protein polyglycylation [GO:0018094]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; tubulin-glycine ligase activity [GO:0070738]" AIAHAMK;GLLPPAGPCKRCR;QWFLVTDWNPLTIWFYK 3 4.4 0.91298 -0.38297 10.5167 0 0 0 0 5.89968 8.26679 0 0 0 0 0 A6PVI3 NCB2L_HUMAN Nuclear cap-binding protein subunit 2-like NCBP2L Homo sapiens (Human) "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]" nuclear cap binding complex [GO:0005846] RNA cap binding [GO:0000339] DPALELSCYRDHQFSGRK;TACGFCFVECHNR 2 20.3 0.84719 -0.072003 0 0 0 0 0 8.77452 7.2926 0 0 0 0 0 A6PVS8 LRIQ3_HUMAN Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44) LRRIQ3 LRRC44 Homo sapiens (Human) GYEAKWIYITK;TFSDIDKYYTEQK;TKVAIVKTNLDFK;VPNGLIK 4 7.1 0.97493 -2.3604 0 0 7.1811 3.09597 4.1842 3.82975 0 0 0 0 0 0 A6PVS8 LRIQ3_HUMAN Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44) LRRIQ3 LRRC44 Homo sapiens (Human) GYEAKWIYITK;KLWVNFH 2 6 0.93319 -0.50042 0 0 0 10.4718 0 0 0 0 0 0 0 0 A6PVY3 F177B_HUMAN Protein FAM177B FAM177B Homo sapiens (Human) LSWGPYLR;SERRGSK 2 9.5 0.93685 -0.54274 0 0 0 10.2826 0 0 0 0 0 0 0 0 A6QL63 ABTB3_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11) ABTB3 BTBD11 Homo sapiens (Human) "exploration behavior [GO:0035640]; protein stabilization [GO:0050821]; synaptic transmission, glutamatergic [GO:0035249]" glutamatergic synapse [GO:0098978]; membrane [GO:0016020] PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982] FFQLEALQRHCEIICAK;GADPLIGTMYR;IAFQQHR;LSTLVSRALVRIAK 4 4.4 0.83001 -0.022843 0 0 0 0 0 0 0 0 0 6.33435 0 0 A6QL63 ABTB3_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11) ABTB3 BTBD11 Homo sapiens (Human) "exploration behavior [GO:0035640]; protein stabilization [GO:0050821]; synaptic transmission, glutamatergic [GO:0035249]" glutamatergic synapse [GO:0098978]; membrane [GO:0016020] PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982] GADPLIGTMYR;IAFQQHR;LSTLVSRALVRIAK;NNEIMEVRDPLWCWLS 4 4.8 0.95524 -0.82519 0 0 0 0 7.90869 0 0 0 5.14111 6.80077 8.2717 0 A6QL64 AN36A_HUMAN Ankyrin repeat domain-containing protein 36A ANKRD36 ANKRD36A KIAA1641 UNQ2430/PRO499 Homo sapiens (Human) ATSDKTDSALNIATEIK;CELNLCDREDR;DIEKMYKSGYNTMEK;EEIKSQLKHEILELEK;IAGDYAIEAK;ILQHSSLMLQVFES;KDGEKTK 7 4.7 0.97243 -2.8206 0 15.0199 0 0 0 12.1342 0 10.4488 10.1587 0 0 8.89239 A6QL64 AN36A_HUMAN Ankyrin repeat domain-containing protein 36A ANKRD36 ANKRD36A KIAA1641 UNQ2430/PRO499 Homo sapiens (Human) DIEKMYKSGYNTMEK;EEIKSQLKHEILELEK;MYPFCFSVSSQK 3 6 0.80911 0.0093823 0 0 0 0 0 0 0 0 0 0 8.05967 0 A6ZKI3 RTL8C_HUMAN Retrotransposon Gag-like protein 8C (Mammalian retrotransposon derived protein 8C) RTL8C CXX1 FAM127A MAR8 MAR8C MART8 Homo sapiens (Human) VQLIKALLALPIRPATR 1 15 0.82967 -0.022755 0 0 0 0 5.77276 0 0 0 4.12027 0 6.00589 0 A7E2F4 GOG8A_HUMAN Golgin subfamily A member 8A (88 kDa Golgi matrix protein) (GM88) (GM88 autoantigen) GOLGA8A KIAA0855 Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] EQILLKGHVTQLK;LNTDLYHMK 2 3.5 0.92383 -0.44961 0 9.8231 0 0 0 0 0 0 0 0 0 0 A7E2S9 A30BL_HUMAN Putative ankyrin repeat domain-containing protein 30B-like ANKRD30BL NCRNA00164 Homo sapiens (Human) NANANAVDK 1 3.6 0.90918 -0.3159 0 9.67269 0 0 0 0 0 0 0 0 0 0 A7E2U8 CFA96_HUMAN Cilia-and flagella-associated protein 96 CFAP96 C4orf47 Homo sapiens (Human) 9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881] APGKNLYTNPGK;DDKIFHPPSGPK;LANISGK;TISNTFKPSSPGK 4 14.2 0.98112 -1.7615 8.85792 11.4154 0 8.90265 0 9.98613 0 0 0 0 9.25001 0 A7E2V4 ZSWM8_HUMAN Zinc finger SWIM domain-containing protein 8 ZSWIM8 KIAA0913 Homo sapiens (Human) positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270] AKALGGAGSGSKGSAGGGSK;DDQAKLKK;GDLALALMITYK;GSAGGGSK;LSPAHAHNHLR;MRDGLVIPLVELSAK;VTSCSCTCGAGAK 7 4.3 0.95426 -0.9045 12.5161 0 0 0 0 0 9.64449 12.0476 0 0 0 9.77104 A7E2V4 ZSWM8_HUMAN Zinc finger SWIM domain-containing protein 8 ZSWIM8 KIAA0913 Homo sapiens (Human) positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270] AKALGGAGSGSKGSAGGGSK;DDQAKLKK;GDLALALMITYK;GSAGGGSK;LCECDPECPQR;MRDGLVIPLVELSAK;VTSCSCTCGAGAK 7 4.2 0.89548 -0.24266 9.32091 0 0 0 0 0 0 0 0 0 0 0 A7E2Y1 MYH7B_HUMAN "Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)" MYH7B KIAA1512 Homo sapiens (Human) regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cytosolic calcium ion concentration [GO:0051480] cardiac myofibril [GO:0097512]; cytoplasm [GO:0005737]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AEAARELEELSER;ATYDRLFR;EKQATENK;ICRQGFPNR;LAKVLTLLQAR;LEDECTELK;LLEEKECLISQLSRGK;LLYTDFRQR;NLARMQDLVDKLQSK;QAEGAAELGEQVDSLQRVR;SIQELEKTK;VWVPDEQDAYVEAEVK 12 7.2 0.97711 -5.745 6.07656 0 12.3495 0 0 8.04221 2.14369 6.92861 0 0 9.94927 0 A7MBM2 DISP2_HUMAN Protein dispatched homolog 2 DISP2 C15orf36 DISPB KIAA1742 LINC00594 Homo sapiens (Human) smoothened signaling pathway [GO:0007224] membrane [GO:0016020]; plasma membrane [GO:0005886] QAGPSPK;WLLALCHR 2 1.1 0.91796 -0.40825 0 0 0 0 9.75787 9.2949 0 0 0 0 0 0 A7MCY6 TBKB1_HUMAN TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) TBKBP1 KIAA0775 SINTBAD Homo sapiens (Human) defense response to virus [GO:0051607]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554] metal ion binding [GO:0046872] SPASPSCPSPVPQR 1 2.3 0.78289 0.024464 0 0 0 0 7.26397 0 0 0 0 0 0 0 A7MD48 SRRM4_HUMAN Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100) SRRM4 KIAA1853 Homo sapiens (Human) "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sensory perception of sound [GO:0007605]" nucleus [GO:0005634] identical protein binding [GO:0042802]; mRNA binding [GO:0003729] ERDPKYSEK 1 1.5 0.97442 -1.424 0 0 11.9599 0 0 0 0 0 0 0 0 0 A7XYQ1 SOBP_HUMAN Sine oculis-binding protein homolog (Jackson circler protein 1) SOBP JXC1 Homo sapiens (Human) animal organ development [GO:0048513]; cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] nucleus [GO:0005634] metal ion binding [GO:0046872]; SUMO polymer binding [GO:0032184] IPTPVPK;SFCSEKCFAACR 2 2.2 0.96525 -1.1385 0 0 0 0 0 0 0 0 0 7.43788 0 0 A8K0R7 ZN839_HUMAN Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) ZNF839 C14orf131 Homo sapiens (Human) metal ion binding [GO:0046872] DMDGEQLEGASSEK;EALSNDTTESLAANSRGR;VTSGETK 3 4.2 0.9527 -0.7362 10.7289 0 10.1852 7.96023 7.23582 0 0 0 0 0 0 0 A8K0Z3 WASH1_HUMAN WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) WASHC1 FAM39E WASH1 Homo sapiens (Human) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; negative regulation of autophagy [GO:0010507]; positive regulation of cell migration [GO:0030335]; positive regulation of pseudopodium assembly [GO:0031274]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein ubiquitination [GO:0031396]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; ubiquitin protein ligase binding [GO:0031625] LEKQQQK;TPVRMQHSLAGQTYAVPFIQPDLR 2 6.7 0.96876 -1.3302 0 0 0 0 0 0 0 0 0 0 8.83753 0 A8K2U0 A2ML1_HUMAN Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9) A2ML1 CPAMD9 Homo sapiens (Human) regulation of endopeptidase activity [GO:0052548] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867] FIFIDPKNIQDALK;VSGVGNNISFEEK 2 1.9 0.91752 -0.42034 0 0 0 0 0 0 5.17225 10.7459 0 0 0 0 A8K4G0 CLM7_HUMAN CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) CD300LB CD300B CLM7 CMRF35A2 IREM3 LMIR5 TREM5 UNQ2530/PRO6029 Homo sapiens (Human) immune response-activating signaling pathway [GO:0002757] plasma membrane [GO:0005886] identical protein binding [GO:0042802] DDADVYWCGIERR;VPILLILVTAILWLK 2 13.9 0.91659 -0.34213 0 0 0 0 0 0 0 0 0 4.17273 0 0 A8K554 ZN815_HUMAN Putative protein ZNF815 ZNF815P ZNF815 Homo sapiens (Human) SLMCNLDFTPNAYLARRR 1 13.8 0.86216 -0.0828 0 0 6.08181 0 0 0 0 0 0 0 0 0 A8K7I4 CLCA1_HUMAN Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1) CLCA1 CACC1 Homo sapiens (Human) calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508] extracellular region [GO:0005576]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ALGGVNAARR;DKFNESLQVNTTALIPK;IVCLVLDK;NTKMAYLQIPGIAK;NVAILIPETWK;NVAILIPETWKTK;VTGLYEK 7 7.5 0.97659 -2.2847 0 0 0 10.0316 8.62304 7.34767 0 11.0204 7.55328 0 0 0 A8K855 EFCB7_HUMAN EF-hand calcium-binding domain-containing protein 7 EFCAB7 KIAA1799 Homo sapiens (Human) positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to ciliary membrane [GO:1903569]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to motile cilium [GO:0120229]; regulation of smoothened signaling pathway [GO:0008589] ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane protein complex [GO:0098797] calcium ion binding [GO:0005509] CDEDAWAVCR 1 1.6 0.89631 -0.24923 0 0 0 0 0 0 0 2.97266 0 0 0 5.18293 A8K8P3 SFI1_HUMAN Protein SFI1 homolog (hSFI1) SFI1 KIAA0542 Homo sapiens (Human) centriole [GO:0005814]; cytosol [GO:0005829] phosphatase binding [GO:0019902] GTHTCTR;HQEQEWQTVACAHHR;TFQASTHYR;VIKQRMEK 4 3.1 0.97776 -2.1648 0 11.178 0 0 0 0 0 0 0 8.32998 0 11.8845 A8K8V0 ZN785_HUMAN Zinc finger protein 785 ZNF785 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SCSERRAWQQAVVGR;SEPIPVLGGKDPPVHFR 2 7.9 0.96488 -1.2204 0 11.3559 0 0 0 0 0 0 0 0 0 0 A8K979 ERI2_HUMAN ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) ERI2 EXOD1 KIAA1504 Homo sapiens (Human) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ICLSQFCK;LFYRRKPK;SLNKVPTK;WEQTLQKER 4 4.8 0.97634 -4.6442 12.4396 11.8972 11.8082 0 10.1539 0 0 0 10.4833 0 11.1504 0 A8K979 ERI2_HUMAN ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) ERI2 EXOD1 KIAA1504 Homo sapiens (Human) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ICLSQFCK;LFYRRKPK;SLHHLIAPQ;SLNKVVPKGIHAVPK 4 14.3 0.93042 -0.4788 0 4.52682 0 3.43696 0 3.66448 0 0 0 11.8045 11.4837 0 A8MPS7 YDJC_HUMAN Carbohydrate deacetylase (EC 3.5.1.-) YDJC Homo sapiens (Human) carbohydrate metabolic process [GO:0005975] deacetylase activity [GO:0019213]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287] VLTAPTLR 1 2.5 0.91465 -0.38032 0 0 0 14.5189 0 0 0 0 0 17.4216 0 11.052 A8MPX8 PP2D1_HUMAN Protein phosphatase 2C-like domain-containing protein 1 PP2D1 C3orf48 Homo sapiens (Human) signal transduction [GO:0007165] protein serine/threonine phosphatase activity [GO:0004722] LLSSFMFTEK;TSTFDSDEDILLLPK 2 6.8 0.95254 -0.74994 0 0 0 0 0 9.711 0 0 0 0 0 0 A8MPY1 GBRR3_HUMAN Gamma-aminobutyric acid receptor subunit rho-3 (GABA(A) receptor subunit rho-3) (GABAAR subunit rho-3) (GABA(C) receptor) GABRR3 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594] SICSPSTDSSR 1 2.4 0.79795 0.014977 0 0 0 0 6.14855 0 0 0 0 0 0 0 A8MQ14 ZN850_HUMAN Zinc finger protein 850 ZNF850 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SALIQHQRIHTGEKPYHCK;YSCKECGK 2 2.5 0.91736 -0.35681 0 0 0 0 0 6.31159 0 0 0 4.85972 0 0 A8MQ27 NEU1B_HUMAN E3 ubiquitin-protein ligase NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL1B) NEURL1B NEURL3 Homo sapiens (Human) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; early endosome [GO:0005769] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] APGPPPADAAAAAIPCGPR;LDGHSRRATR 2 5.2 0.83789 -0.037203 0 0 0 10.2496 9.75171 0 0 0 0 0 0 0 A8MQB3 CQ051_HUMAN Putative uncharacterized protein LINC02693 LINC02693 C17orf51 Homo sapiens (Human) LCPGGHRPASLSSGCPAGCR 1 9 0.78323 0.025586 0 0 0 0 0 0 0 0 0 0 7.51909 0 A8MSI8 LYRM9_HUMAN LYR motif-containing protein 9 LYRM9 C17orf108 HSD24 Homo sapiens (Human) mitochondrion [GO:0005739] APLPGAELVRRPLQLYR 1 21.8 0.88508 -0.18134 0 0 0 11.4668 0 0 0 0 0 0 0 0 A8MT19 RHN2P_HUMAN Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) RHPN2P1 Homo sapiens (Human) negative regulation of stress fiber assembly [GO:0051497] ISLPGIRNEFFMLVK;QWMPPRSNR 2 4.1 0.9752 -1.4453 0 0 0 0 0 8.44286 0 0 0 0 0 0 A8MT33 SYC1L_HUMAN Synaptonemal complex central element protein 1-like (Meiosis-related protein) SYCE1L Homo sapiens (Human) synaptonemal complex assembly [GO:0007130] intermediate filament cytoskeleton [GO:0045111]; synaptonemal complex [GO:0000795] GQLEDLMGQHKDLWEFHMLEQR;INDLQQAK;SAPEVGAGEGEAGPELPR 3 19.8 0.93682 -0.52589 0 7.93162 0 0 0 0 0 0 5.41305 0 0 0 A8MT70 ZBBX_HUMAN Zinc finger B-box domain-containing protein 1 ZBBX Homo sapiens (Human) metal ion binding [GO:0046872] EKVQLEFENQEMEK;EPLNIELK;LVNQSYMMSQNK 3 4.4 0.9753 -1.4322 0 7.26987 0 0 0 0 0 0 0 0 0 0 A8MTA8 CMI2B_HUMAN Ciliary microtubule inner protein 2B CIMIP2B FAM166B Homo sapiens (Human) axonemal microtubule [GO:0005879]; motile cilium [GO:0031514] TLLPPIRPPRSPEVPRESLPVR 1 10.2 0.56027 0.18276 0 0 0 0 0 0 0 0 0 0 0 9.90094 A8MTY0 ZN724_HUMAN Zinc finger protein 724 ZNF724 ZNF724P Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNLSSHLTTHK;CEECGKAFYQYSNLTQHK;TEKNPFKCK;VIHTGEKPYKCK 4 8.2 0.97316 -2.5839 0 11.0896 8.57149 0 0 9.97528 0 0 0 0 0 0 A8MTZ0 BBIP1_HUMAN BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa) BBIP1 BBIP10 NCRNA00081 Homo sapiens (Human) B cell homeostasis [GO:0001782]; cilium assembly [GO:0060271]; eating behavior [GO:0042755]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; protein transport [GO:0015031]; receptor localization to non-motile cilium [GO:0097500]; Wnt signaling pathway [GO:0016055] BBSome [GO:0034464]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829] AEVKSMFREVLPK 1 18.6 0.86616 -0.091892 0 0 0 0 0 0 0 0 0 10.0983 0 0 A8MTZ7 CL071_HUMAN Uncharacterized protein C12orf71 C12orf71 Homo sapiens (Human) ERTKLSVGK 1 3.3 0.97546 -1.4729 0 12.4516 0 0 0 0 13.5195 0 0 0 0 14.0858 A8MU46 SMTL1_HUMAN Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of vasoconstriction [GO:0045907]; response to activity [GO:0014823]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310] contractile muscle fiber [GO:0043292]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; I band [GO:0031674]; M band [GO:0031430]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634] calmodulin binding [GO:0005516]; CH domain binding [GO:0051401]; disordered domain specific binding [GO:0097718]; protein phosphatase 1 binding [GO:0008157]; tropomyosin binding [GO:0005523] EAGGKEDAEAELK 1 2.6 0.96497 -1.2507 0 0 0 0 0 0 9.67032 9.81617 9.72171 0 0 0 A8MUI8 YA034_HUMAN Putative UPF0607 protein ENSP00000383783 Homo sapiens (Human) SLIEKNQTDK;VLSRTSK 2 5 0.92117 -0.44367 0 0 0 0 0 0 7.11541 0 0 0 0 0 A8MUM7 LEG16_HUMAN Galectin-16 LGALS16 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of T cell apoptotic process [GO:0070234] carbohydrate binding [GO:0030246]; lactose binding [GO:0030395] DVSLDSVLVNNGRR 1 9.9 0.92852 -0.4828 0 0 0 9.58291 0 0 0 0 0 0 0 0 A8MUN3 YQ048_HUMAN Putative uncharacterized protein ENSP00000381830 Homo sapiens (Human) extracellular region [GO:0005576] SFEYRHYK 1 6.1 0.91291 -0.33804 0 0 0 0 0 0 0 0 0 0 0 10.8477 A8MUU9 YV023_HUMAN Putative uncharacterized protein ENSP00000383309 Homo sapiens (Human) TPPRTSQRR;TPSTASLTRTPSRASLTR;TPYTASLTR 3 7.1 0.97494 -1.3915 0 7.69738 0 0 0 0 0 0 0 0 7.75455 0 A8MUV8 ZN727_HUMAN Putative zinc finger protein 727 (Zinc finger protein 727 pseudogene) ZNF727 ZNF727P Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFGLCSIFTEHKK;CEECGKACK;GQKSSYNGIHQCLSATRSK;LSDFTIQK 4 9.8 0.9386 -0.57321 0 11.2815 0 0 10.3188 11.6235 0 0 11.7805 12.2401 0 11.4064 A8MV65 VGLL3_HUMAN Transcription cofactor vestigial-like protein 3 (Vgl-3) VGLL3 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] QEEEDEEEEEEEK 1 4 0.70989 0.15876 0 0 0 0 0 0 7.89585 0 0 5.80527 0 0 A8MV72 YH009_HUMAN Putative UPF0607 protein ENSP00000382826 Homo sapiens (Human) AAGHRSR;QGRRGGSCL;VLSRTSK 3 7.4 0.97157 -1.3523 10.4716 7.40676 0 0 0 0 0 0 0 0 0 0 A8MVA2 KRA96_HUMAN Keratin-associated protein 9-6 (Keratin-associated protein 9-like 2) KRTAP9-6 KAP9.6 KRTAP9.6 KRTAP9L2 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] MTHCCSPGCQPTCCRTTCCR;THCCSPGCQPTCCR 2 12.5 0.90606 -0.27267 0 0 0 0 5.05242 0 5.05102 0 0 0 0 0 A8MVM7 YD021_HUMAN Putative uncharacterized protein ENSP00000382790 Homo sapiens (Human) IHASFENKFKSEAK;ITEMSTKRHK;LENVCPNSWRSK;RNLRFFCQNQFLNK;SKTLKDCR 5 8.8 0.97317 -2.515 0 0 11.0522 10.1887 0 0 0 0 0 9.27594 0 10.459 A8MVW0 F1712_HUMAN Protein FAM171A2 FAM171A2 Homo sapiens (Human) membrane [GO:0016020] LLPLLGLLLGSASRAPGK 1 2.2 0.92168 -0.44348 0 0 0 0 0 3.54696 0 0 0 0 0 0 A8MVW5 HECA2_HUMAN HEPACAM family member 2 (Mitotic kinetics regulator) HEPACAM2 MIKI UNQ305/PRO346 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819] IYLLLFGACSGLK;VAQKTMDYVCCAYNNITGR 2 6.9 0.88875 -0.18399 0 5.70752 0 10.433 3.33557 0 0 0 0 7.79565 0 0 A8MVW5 HECA2_HUMAN HEPACAM family member 2 (Mitotic kinetics regulator) HEPACAM2 MIKI UNQ305/PRO346 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819] IYLLLFDIVANCLLLR;VAQKTMDYVCCAYNNITGR 2 7.2 0.60277 0.17781 0 0 0 0 0 9.52101 0 0 0 0 0 0 A8MVX0 ARG33_HUMAN Rho guanine nucleotide exchange factor 33 ARHGEF33 Homo sapiens (Human) guanyl-nucleotide exchange factor activity [GO:0005085] AAQAHGPAAAAVAARGASR;KYVINISLILKIK;SCLSADIQSKGHLPSGMWR;SVHVGDSNVK;YVINISLILK;YVINISLILKIK 6 7.2 0.98031 -1.8642 0 10.0326 0 0 0 4.9055 0 0 12.1114 0 4.51128 0 A8MVZ5 BTNLA_HUMAN Putative butyrophilin-like protein 10 pseudogene BTNL10P BTNL10 Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] TTFMSDHVARGK;VTTFDNRTYCCR 2 8.2 0.98051 -1.7952 0 5.44108 0 0 0 0 0 0 0 0 0 0 A8MW92 P20L1_HUMAN PHD finger protein 20-like protein 1 PHF20L1 CGI-72 Homo sapiens (Human) negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein catabolic process [GO:0042177]; regulation of transcription by RNA polymerase II [GO:0006357] NSL complex [GO:0044545]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034] DPPGQRWSAK;EWLNNGRMCGLSFFKENYSHLNAK;MLVHFER;SSTAFGKRK 4 4.9 0.9729 -2.9615 0 0 0 6.02987 0 0 0 0 0 0 0 0 A8MW92 P20L1_HUMAN PHD finger protein 20-like protein 1 PHF20L1 CGI-72 Homo sapiens (Human) negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein catabolic process [GO:0042177]; regulation of transcription by RNA polymerase II [GO:0006357] NSL complex [GO:0044545]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034] AMPEDAKGQDWIALVK;MLVHFER 2 8.1 0.81246 -0.013641 0 0 0 0 0 4.17009 0 0 0 0 0 0 A8MW95 BECN2_HUMAN Beclin-2 (Beclin-1 autophagy-related pseudogene 1) (Beclin-1-like protein 1) BECN2 BECN1L1 BECN1P1 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to nitrogen starvation [GO:0006995]; endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]; glucose homeostasis [GO:0042593]; late endosome to vacuole transport [GO:0045324]; mitophagy [GO:0000423] "phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" phosphatidylinositol 3-kinase binding [GO:0043548]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674] LVQELEDVDR 1 2.3 0.86678 -0.092934 9.34713 0 0 0 0 0 0 0 0 0 0 0 A8MWA4 Z705E_HUMAN Putative zinc finger protein 705EP (zinc finger protein 705E pseudogene) ZNF705EP ZNF705E Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QCGKSLSNLLSPKPHK 1 5.3 0.91566 -0.43413 0 0 0 0 0 0 0 0 0 3.2684 0 0 A8MWK0 FS2P1_HUMAN "Putative fatty acid desaturase 2-like protein FADS2B (Fatty acid desaturase 2 pseudogene 1) (Fatty acid desaturase 2B, pseudogene)" FADS2B FADS2P1 Homo sapiens (Human) lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" QEANGKCSTPR;YINYEEQHLYFYK 2 5 0.96678 -1.2866 0 0 0 0 0 0 0 0 0 10.2649 0 0 A8MWY0 ELAP2_HUMAN Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (Estrogen-induced gene 121-like protein) (hEIG121L) ELAPOR2 EIG121L KIAA1324L Homo sapiens (Human) negative regulation of nervous system development [GO:0051961]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epidermis development [GO:0045684] membrane [GO:0016020]; plasma membrane [GO:0005886] BMP receptor binding [GO:0070700] DYHFEYTECDSSGSR;EDLTDAIR;GWGRPAEAPR;WWNVLPGNMK 4 4.2 0.95424 -0.91465 0 0 0 0 0 0 0 11.3944 0 14.2291 4.70022 0 A8MX76 CAN14_HUMAN Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14) CAPN14 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] HRPEYLVK;TLIGCQTHSGEK 2 2.9 0.91537 -0.37686 9.43189 0 0 0 0 0 0 0 0 10.3742 0 0 A8MX80 YM017_HUMAN Putative UPF0607 protein ENSP00000383144 Homo sapiens (Human) TEVRAEEPKEATEVK;VLSRTSK 2 6.5 0.85022 -0.073855 0 0 0 0 0 0 0 7.16461 0 0 0 0 A8MXD5 GRCR1_HUMAN Glutaredoxin domain-containing cysteine-rich protein 1 GRXCR1 DFNB25 Homo sapiens (Human) cochlea development [GO:0090102]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell development [GO:0060119]; inner ear receptor cell stereocilium organization [GO:0060122]; sensory perception of sound [GO:0007605]; vestibular receptor cell development [GO:0060118] kinocilium [GO:0060091]; microvillus [GO:0005902]; stereocilium [GO:0032420] ELDERCRR 1 2.8 0.8705 -0.095167 0 5.58265 0 0 0 7.26894 0 0 7.72751 0 0 0 A8MXE2 B3GT9_HUMAN "Beta-1,3-galactosyltransferase 9 (EC 2.4.1.-) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10)" B3GALT9 B3GNT10 Homo sapiens (Human) protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758] EINKESCK 1 2.2 0.91288 -0.33804 0 0 0 0 0 9.65884 9.60872 0 0 0 0 0 A8MXQ7 IQAK1_HUMAN IQ motif and ankyrin repeat domain-containing protein 1 IQANK1 Homo sapiens (Human) EPASAESPQAPTGPAEDR 1 3.2 0.90333 -0.26484 0 0 0 0 0 0 11.7126 0 0 0 0 0 A8MXV4 NUD19_HUMAN Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19) NUDT19 Homo sapiens (Human) butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289] cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782] coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287] EGKQFHR;FCLGRALEGLER;LANFASLSDLHK;RAASIVLAAGWSRPETATPPSRPPPAEGFR 4 16.3 0.97488 -2.367 0 0 0 0 0 0 0 0 9.18802 0 9.16133 10.1174 A8MXV6 CD15L_HUMAN CMT1A duplicated region transcript 15 protein-like protein CDRT15L2 Homo sapiens (Human) membrane [GO:0016020] RNLLLQAWKCVCNWASR;SHAAPSPGHGGK 2 10.3 0.96536 -1.2548 0 0 12.5824 0 0 0 0 0 0 0 0 0 A8MXY4 ZNF99_HUMAN Zinc finger protein 99 ZNF99 C19orf9 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNISSMFTKCKIIHTGK;AIHTGEKPYK;HEIIHTGEKSYK;KHEIIHTGEKSYK;MHEEAYNK 5 6.8 0.98022 -2.0409 0 0 7.69502 8.79805 0 0 0 0 8.21563 10.6672 0 6.65464 A8MY62 BLML_HUMAN Putative beta-lactamase-like 1 LACTBL1 Homo sapiens (Human) CPRHPEPVPLAHPLPVLKEALEK 1 4.6 0.5993 0.17852 0 0 0 0 6.35616 0 0 0 0 0 0 0 A8MYA2 CX049_HUMAN Uncharacterized protein CXorf49 CXorf49; CXorf49B Homo sapiens (Human) EIEDLTQQLAAMQFLTDK;KTRESQAAAR;LSVRRGEFSSSDPNIR;VDPQQPSAK;VSVCGAGFDLEGGK 5 13 0.91681 -0.42874 0 0 0 10.5902 2.36376 0 0 8.2854 10.6182 11.2974 9.69098 0 A8MYJ7 TTC34_HUMAN Tetratricopeptide repeat protein 34 (TPR repeat protein 34) TTC34 Homo sapiens (Human) AGPSRAQGR;RPQAAPVLARLALLQLRR 2 4.8 0.96516 -1.1627 0 0 0 0 0 0 0 5.27045 0 0 0 0 A8MYU2 KCNU1_HUMAN "Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)" KCNU1 KCNMA3 KCNMC1 SLO3 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805]; reproductive process [GO:0022414] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] potassium channel activity [GO:0005267] ALRLLELPQILQILRAIK;FSKLLSIILSTWFTAAGFIHLVENSGDPWLK;IIDEEELNPENK;LSDDFAGMSFPEVAR;VPILTELK 5 7.3 0.97638 -2.2506 0 0 0 0 0 0 5.58803 9.20178 0 10.9256 0 0 A8MYV0 DCD2C_HUMAN Doublecortin domain-containing protein 2C DCDC2C Homo sapiens (Human) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; sperm flagellum [GO:0036126] KKTLAEPLVQR;KLFTMNGHLLGDSK 2 6.9 0.095092 0.37203 0 0 0 0 0 0 0 13.1602 13.1258 0 6.78882 0 A8MYZ0 MIY4B_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B (Protein FAM188B2) MINDY4B C3orf76 FAM188B2 Homo sapiens (Human) protein K48-linked deubiquitination [GO:0071108] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] DASEDDR 1 1.5 0.9118 -0.32293 4.4272 0 0 0 0 0 0 0 0 0 0 0 A8MZ25 YQ037_HUMAN Putative uncharacterized protein FLJ38767 Homo sapiens (Human) SGACLAR 1 4.3 0.82194 -0.017918 0 0 0 0 0 0 0 0 0 0 10.725 0 A8MZ26 EFCB9_HUMAN EF-hand calcium-binding domain-containing protein 9 EFCAB9 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891] LNYQEFK;LYTIIYTDK 2 8.1 0.9542 -0.90657 0 0 0 0 0 0 9.68626 0 0 0 0 0 A8TX70 CO6A5_HUMAN Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) cell adhesion [GO:0007155] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] extracellular matrix structural constituent conferring tensile strength [GO:0030020] EICQSCGK;GITIFAVGVGK;IHKPDLNYIAKFLKPFLYSVRR;IITFQDFDK;KGVKGPR;KLIFRVCALHDCK;TQIQNVSK;VGSDEFK;VVEPAKR 9 3.5 0.97717 -5.8063 0 0 5.28947 0 0 0 8.24897 13.8769 0 14.0691 0 0 A9UHW6 MI4GD_HUMAN MIF4G domain-containing protein (SLBP-interacting protein 1) (hSLIP1) MIF4GD SLIP1 Homo sapiens (Human) cap-dependent translational initiation [GO:0002191]; regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone mRNA stem-loop binding complex [GO:0062073]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; translation activator activity [GO:0008494] TTPAAHK 1 3.2 0.69579 0.16208 0 0 0 0 0 0 0 0 0 0 0 7.19948 A9YTQ3 AHRR_HUMAN Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77) AHRR BHLHE77 KIAA1234 Homo sapiens (Human) xenobiotic metabolic process [GO:0006805] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]" EEEQHRMLSRASGVTGR;FLFGQKK;LKFLFGQKK;LSVLRLSVSYLRVK;LSVSYLR;VRCLLDSTSGFLTMQFQGKLK 6 8.4 0.91123 -0.28711 0 0 0 3.87971 0 5.68128 0 0 0 0 8.3102 8.88127 B0I1T2 MYO1G_HUMAN Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] MYO1G HA2 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cell gliding [GO:0071976]; cell-substrate adhesion [GO:0031589]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; T cell meandering migration [GO:0120117]; T cell mediated immunity [GO:0002456]; T cell migration [GO:0072678] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886] "actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ARLIPIIVLLLQK;HHLHYTSR;LDENHCR;LDPDRQYRVMR;RLLYNSTDPTLR;TNRNHNSSRFGK;TVASGGRELIEK 7 7.4 0.93691 -0.54364 0 10.8506 10.3225 0 8.71723 0 9.34851 0 8.04078 5.93008 7.77419 0 B0YJ81 HACD1_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A) HACD1 PTPLA Homo sapiens (Human) cementum mineralization [GO:0071529]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]; protein-containing complex assembly [GO:0065003]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; hydroxyapatite binding [GO:0046848]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] TGMFSIR;VLHGEVIVEK 2 5.9 0.95126 -0.71502 0 9.03584 0 0 0 0 0 10.2577 9.49474 0 0 0 B1AJZ9 FHAD1_HUMAN Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) FHAD1 KIAA1937 Homo sapiens (Human) AYLKSAEGFFVLNK;DEIILLLGKEVSRLSDYEIESK;EMLRKETSSK;ITQLKNQLGRK;LCKTQIQDMEK;VEEKLQEDSR;VQDLENHLTQQK;VTQHHKK 8 6.9 0.76667 0.059369 0 0 0 0 0 0 0 0 8.07339 0 0 0 B1AJZ9 FHAD1_HUMAN Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) FHAD1 KIAA1937 Homo sapiens (Human) AYLKSAEGFFVLNK;DEIILLLGKEVSRLSDYEIESK;IDTLQLCLQRER;ITQLKNQLGRK;LCKTQIQDMEK;VEEKLQEDSR;VQDLENHLTQQK;VTQHHKK 8 6.8 0.97673 -5.5899 0 12.8108 0 12.0118 6.85537 7.79597 11.2161 11.049 11.4835 9.67342 8.66945 10.2437 B1AK53 ESPN_HUMAN Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) ESPN DFNB36 LP2654 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; microvillar actin bundle assembly [GO:0030034]; sensory perception of sound [GO:0007605] brush border [GO:0005903]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; microvillus [GO:0005902]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124] LASMPAWR;LLVEHYPEGVNAQTK;YLRTVENLSVEHRVLSR 3 4.7 0.9168 -0.42665 0 0 0 0 0 0 10.81 0 0 8.4849 0 0 B1AK53 ESPN_HUMAN Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) ESPN DFNB36 LP2654 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; microvillar actin bundle assembly [GO:0030034]; sensory perception of sound [GO:0007605] brush border [GO:0005903]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; microvillus [GO:0005902]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124] LASMPAWR;MAHSEEAALLPGNHVPNGCAADPK 2 11.1 0.80699 0.0084121 0 0 0 0 0 0 0 0 0 0 0 6.38071 B1AK76 SNUFL_HUMAN Putative SNURF-like protein SNURFL CXorf19 Homo sapiens (Human) nuclear speck [GO:0016607] QVFITETPR 1 7.4 0.93582 -0.53286 0 0 0 0 0 0 0 0 0 10.9241 0 0 B1AKI9 ISM1_HUMAN Isthmin-1 ISM1 C20orf82 ISM Homo sapiens (Human) negative regulation of angiogenesis [GO:0016525] extracellular region [GO:0005576] GAGTPNLISTEFSAELHYK;MVRLAAELLLLLGLLLLTLHITVLR;VRLAAELLLLLGLLLLTLHITVLR 3 9.5 0.84121 -0.049646 0 9.42939 0 0 0 0 0 0 0 6.9318 0 9.65828 B1AL88 NALF1_HUMAN NALCN channel auxiliary factor 1 (Transmembrane protein FAM155A) NALF1 FAM155A NLF-1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703] plasma membrane [GO:0005886] IWLAAPR;SCPEDCK 2 3.1 0.88126 -0.15237 0 0 0 0 0 0 4.81793 0 0 0 4.55115 8.80603 B1AMM8 CI107_HUMAN Putative uncharacterized protein encoded by LINC00587 LINC00587 C9orf107 Homo sapiens (Human) RTNSMSK 1 9.6 0.78736 0.01764 0 0 0 0 0 5.61615 0 0 0 0 0 0 B1ANS9 WDR64_HUMAN WD repeat-containing protein 64 WDR64 Homo sapiens (Human) EINVMLYNK;HFKINDILFLFRTPECAR;IVATTER;LQNQVLDSKNFK;SLKKNLVPQINLASSFFPAIPK 5 6.3 0.9754 -3.3551 0 0 0 9.0471 0 0 0 0 0 5.03672 0 11.8655 B1APH4 ZN487_HUMAN Putative zinc finger protein 487 (KRAB domain only protein 1) ZNF487 KRBO1 ZNF487P Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QCFEYNQCGK 1 4.8 0.3117 0.24887 0 8.73948 0 0 0 0 5.12747 0 0 0 0 0 B2RBV5 MR1L2_HUMAN MORF4 family associated protein 1 like 2 (MORF4 family-associated protein 1-like protein UPP) (Unnamed protein product) (UPP) MRFAP1L2 Homo sapiens (Human) regulation of cell cycle [GO:0051726] ERARAHWR;IAGCECC 2 12.6 0.98105 -1.7839 0 0 0 0 0 0 0 0 0 6.00524 0 0 B2RC85 R10B2_HUMAN Radial spoke head 10 homolog B2 RSPH10B2 Homo sapiens (Human) 9+2 motile cilium [GO:0097729]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ELTAATFMEVIAEDNR;KHGMGRLTFK 2 3 0.88047 -0.15375 0 0 10.6993 0 10.3533 0 0 0 0 0 0 0 B2RPK0 HGB1A_HUMAN Putative high mobility group protein B1-like 1 (High mobility group protein B1 pseudogene 1) (Putative high mobility group protein 1-like 1) (HMG-1L1) HMGB1P1 HMG1L1 HMGB1L1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" GDPKKPR;GEHPGLSIGDVAK;HSDASVNFSEFSNKCSER;IKGEHPGLSIGDVAK 4 19 0.82578 -0.02067 0 9.70688 0 0 0 0 0 0 0 0 0 0 B2RTY4 MYO9A_HUMAN Unconventional myosin-IXa (Unconventional myosin-9a) MYO9A MYR7 Homo sapiens (Human) cell junction assembly [GO:0034329]; establishment of epithelial cell apical/basal polarity [GO:0045198]; intracellular signal transduction [GO:0035556]; regulation of neuron projection arborization [GO:0150011]; regulation of small GTPase mediated signal transduction [GO:0051056]; visual perception [GO:0007601] actin filament [GO:0005884]; axonal growth cone [GO:0044295]; cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]; unconventional myosin complex [GO:0016461] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] AAAIVIQQK;AMGLQERKETIR;AYRESKR;EQERQHLQDLLHQEVLRR;FNIQDFFR;IRQSGYSSK;ITKSLLHLHKK;KIILLQSTCRGFR;LCKYACHKK;LSNNRISK;LVYQEHNER;QKQLQQQNEK;QRVERPSSLLSLNTSNK;SLEDLHQK;SLLHLHK;TTAKCSK;TVTVGEK 17 6.4 0.97871 -9.7722 0 11.114 10.1297 0 9.35526 0 8.97628 11.1424 10.136 10.3018 10.6645 0 B2RU33 POTEC_HUMAN "POTE ankyrin domain family member C (ANKRD26-like family B member 2) (Prostate, ovary, testis-expressed protein on chromosome 18) (POTE-18)" POTEC A26B2 POTE18 Homo sapiens (Human) SKMGKCCHHCFPCCR;WCCHCFPCCR;WCCHCFPCCRGSGK 3 5.4 0.50709 0.18795 0 0 0 0 0 0 0 0 6.70376 0 0 0 B2RUY7 VWC2L_HUMAN von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like) VWC2L Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666] AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; synapse [GO:0045202] EVKNFCEYHGKNYK 1 6.3 0.86695 -0.090583 0 7.12784 0 0 0 0 0 0 0 0 0 0 B2RV13 CF97D_HUMAN Sperm axonemal maintenance protein CFAP97D1 (CFAP97 domain-containing protein 1) CFAP97D1 C17orf105 Homo sapiens (Human) sperm axoneme assembly [GO:0007288] IEYENKQLCQKIANAHR;YIRNTTR 2 14.6 0.97481 -1.4364 0 0 0 5.25535 0 0 9.23189 0 8.2791 0 0 0 B2RXF0 T229A_HUMAN Transmembrane protein 229A TMEM229A Homo sapiens (Human) membrane [GO:0016020] AGSDVDSEGPAR;LYFHLHYSRGWGTWK 2 7.1 0.81392 -0.0099398 0 0 0 0 4.00926 0 0 0 0 11.4595 0 0 B2RXF5 ZBT42_HUMAN Zinc finger and BTB domain-containing protein 42 ZBTB42 Homo sapiens (Human) muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" MEFPEHGGR;QERVHPPCVLQTPLCSQRQPGAQPLVK 2 8.5 0.93609 -0.52271 6.90677 0 0 0 0 0 0 0 0 0 0 0 B2RXH4 BTBDI_HUMAN BTB/POZ domain-containing protein 18 BTBD18 Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; piRNA transcription [GO:0140541]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526] nucleus [GO:0005634] ELTELEK 1 1 0.90875 -0.30963 0 0 0 11.2047 10.4879 0 0 12.0733 0 0 0 0 B2RXH8 HNRC2_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) HNRNPCL2 HNRNPCP5 Homo sapiens (Human) nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; RNA binding [GO:0003723] AAVAGEDGR;ASNVTNK;IAGCSVHK;NNEKDAEEGEDNRDSTNGQDDS;QKVDSLLENLEK;SDVEAIFSK;VDSLLENLEK;VFIGNLNTLVVK;YGKIAGCSVHKGFAFVQYDK 9 31.1 0.5609 0.18276 0 0 0 0 0 0 0 0 5.31219 0 0 0 B3EWF7 EP2A2_HUMAN "Laforin, isoform 9" EPM2A Homo sapiens (Human) negative regulation of TOR signaling [GO:0032007]; positive regulation of macroautophagy [GO:0016239] nucleus [GO:0005634] CRPPEAGRHRGGR;GGGAGRGGAGPR 2 7.3 0.96449 -1.1706 0 0 0 0 0 0 0 8.05886 0 8.62242 0 0 B3EWG6 FM25G_HUMAN Protein FAM25G FAM25G Homo sapiens (Human) EVVGHAK 1 7.9 0.92357 -0.44822 0 0 0 0 0 0 0 10.108 10.5729 0 0 0 B3GLJ2 PATE3_HUMAN Prostate and testis expressed protein 3 (Acrosomal vesicle protein HEL-127) (PATE-like protein DJ) (PATE-DJ) PATE3 Homo sapiens (Human) extracellular region [GO:0005576] TYVHTCCNYNYCNFK 1 15.3 0.78306 0.022767 0 0 0 0 0 0 0 0 5.10253 0 0 0 B3KS81 SRRM5_HUMAN Serine/arginine repetitive matrix protein 5 SRRM5 ZNF576 Homo sapiens (Human) EKSDNPSPSSSR;QSGYSRPRASSK;RGSRSSK;SPSKERQCR;SYRPPGGSGIGRSSELAVTPSTAK 5 9 0.97494 -3.6903 0 0 8.05967 0 0 0 0 9.5167 0 10.0831 6.15381 9.08696 B4DH59 NBPFP_HUMAN NBPF family member NBPF26 (Neuroblastoma breakpoint family member 26) NBPF26 Homo sapiens (Human) cytoplasm [GO:0005737] EVQKTEESK;LSPENDNDDDEDVQVEVAEK;MPALRPALLWALLALWLCWAAPAHALQCR;VLVHAQER 4 3.9 0.98017 -1.819 5.03883 0 0 0 9.54967 0 0 0 0 0 0 0 B4DS77 SHSA9_HUMAN Protein shisa-9 SHISA9 Homo sapiens (Human) regulation of short-term neuronal synaptic plasticity [GO:0048172] AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] PDZ domain binding [GO:0030165] KDDPLHDPTK;LNQSTCTNYDTPLWLNTGKPPARK 2 7.8 0.86861 -0.091474 0 0 0 6.90917 0 0 10.3845 10.4603 0 0 0 0 B4DU55 ZN879_HUMAN Zinc finger protein 879 ZNF879 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFTSISRLSRHHR;GSSSLNNHQR 2 4.1 0.96769 -1.3052 0 0 0 0 0 0 10.941 7.93393 0 0 0 0 B4DX44 ZN736_HUMAN Zinc finger protein 736 ZNF736 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFKCFSDLTNHK 1 2.8 0.92406 -0.44876 0 0 0 0 0 0 0 9.95947 0 0 10.4542 0 B4DXR9 ZN732_HUMAN Zinc finger protein 732 ZNF732 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFGWSTYLSK;CEECGKAFLCSR 2 3.8 0.97635 -2.1855 0 0 0 8.892 8.8835 0 0 0 0 0 0 0 B4E2M5 ANR66_HUMAN Ankyrin repeat domain-containing protein 66 ANKRD66 Homo sapiens (Human) ACVAFLEK;GLCDPNYKDVDWNDR 2 11.7 0.98016 -2.005 0 0 0 0 0 0 3.41441 0 0 0 0 11.6596 B5MCN3 S14L6_HUMAN Putative SEC14-like protein 6 SEC14L6 Homo sapiens (Human) cytoplasm [GO:0005737] CLTKINYGGEVPKSYYLCK;SLIVVRAPKLFAVAFNLVK;VVILGDNWK 3 11.8 0.91031 -0.2948 0 0 0 10.3651 0 0 0 0 5.1132 0 0 0 B5MCY1 TDR15_HUMAN Tudor domain-containing protein 15 TDRD15 Homo sapiens (Human) HCDQACCMEKSNK;IDQLMHPK;IDQLMHPKNIHAR;ITESVNLQNFPKYDSNK;KLVLNKAILLQVIAK;KYHSNNLVENNLSLPK;LADALNATARR;LLSNEIRNIPR;LVLNKAILLQVIAKK;NEFQEIMK;NINKFYDLCENDEMILR;NKKILSDLIVLITK;SVKVVSQSFIR;SVSEYSMLNSESK;TVYCEFLKKHDQK;VGQKSVK 16 9.2 0.97531 -3.3917 13.577 12.339 11.2849 9.71855 9.41485 7.87412 12.068 0 12.7829 11.8863 11.6932 11.1479 B6SEH9 ERVV2_HUMAN Endogenous retrovirus group V member 2 Env polyprotein (HERV-V_19q13.41 provirus ancestral Env polyprotein 2) ERVV-2 ENVV2 Homo sapiens (Human) membrane [GO:0016020] TSFYFYNCSSLNQTCCPCPEGHCDR 1 4.7 0.71274 0.15167 0 6.91468 0 0 0 0 0 0 0 0 0 0 B7Z368 CJ142_HUMAN Uncharacterized protein encoded by LINC02881 (Long intergenic non-protein coding RNA 2881) LINC02881 C10orf142 Homo sapiens (Human) QDSAAGNSEER 1 8.5 0.89268 -0.2239 0 0 0 0 0 0 0 0 0 0 8.06803 0 B7Z6K7 ZN814_HUMAN Zinc finger protein 814 ZNF814 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERSYGCGECGK;SFNEKGHLR 2 2.3 0.97662 -1.489 0 0 4.49876 0 0 0 0 0 0 0 0 0 B7Z8K6 TRDC_HUMAN T cell receptor delta constant TRDC Homo sapiens (Human) adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852] gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886] ETENTKQPSKSCHKPK 1 10.5 0.84859 -0.070141 0 0 0 6.48222 0 0 0 0 0 0 0 0 B7ZBB8 PP13G_HUMAN Protein phosphatase 1 regulatory subunit 3G PPP1R3G Homo sapiens (Human) glucose homeostasis [GO:0042593]; glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979] protein phosphatase type 1 complex [GO:0000164] glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157] MEPIGAR 1 2 0.90934 -0.30915 10.2824 0 4.33985 0 0 0 0 0 0 0 0 0 B7ZC32 KIF28_HUMAN Kinesin-like protein KIF28P (Kinesin-like protein 6) KIF28P KLP6 Homo sapiens (Human) mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]; vesicle transport along microtubule [GO:0047496] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] LEQETEPLR;NSGSKCVISMHSR;QSSINLVDLARSER 3 3.7 0.96493 -1.141 0 0 10.6365 0 9.62721 0 0 0 0 0 0 0 B7ZW38 HNRC3_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 3 HNRNPCL3 Homo sapiens (Human) nucleus [GO:0005634] RNA binding [GO:0003723] AAVAGEDGR;ASNVTNK;GAEEGEDDRDRANGQDDS;IAGCSVHK;QKVDSLLENLEK;SDVEAIFSK;VDSLLENLEK;VFIGNLNTLVVK;YGKIAGCSVHKGFAFVQYDK 9 29.7 0.86586 -0.088318 0 0 0 0 0 0 0 5.55182 0 0 0 0 B9A014 F243A_HUMAN Uncharacterized protein C21orf140 (Protein FAM243A) C21orf140 FAM243A Homo sapiens (Human) AYGKCVIVVKER 1 4.8 0.76843 0.057523 0 0 0 0 0 0 0 5.19357 0 0 0 0 C9J069 AJM1_HUMAN Apical junction component 1 homolog AJM1 C9orf172 Homo sapiens (Human) cell-cell junction organization [GO:0045216] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cilium [GO:0005929]; plasma membrane [GO:0005886] LATDSRHYSR;SCHSCYTYYCSR;SCHSCYTYYCSRLCRR;SYENLLGR;VGSVCRHVLQFCR 5 4.8 0.97683 -2.2157 0 0 6.81276 0 0 9.97212 6.7443 0 0 2.22148 0 0 C9J2P7 U17LF_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 (EC 3.4.19.12) USP17L15 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] ALGAEDTDRR;ATQESTLDHWKFLQEQNK;ATQGELK;FLQEQNK;RALLVCQWSQWKYRPTR;RDHPCLQAPELDEHLVER 6 12.7 0.98072 -1.7944 8.50255 0 0 0 11.1833 11.9078 9.67617 8.60585 0 5.97469 0 11.0098 C9J302 CD051_HUMAN Uncharacterized protein C4orf51 C4orf51 Homo sapiens (Human) YCVRPKKPAQEALINYSRR 1 9.4 0.50213 0.18905 0 0 0 0 0 0 10.8581 0 0 0 0 0 C9J6K1 CS081_HUMAN Putative uncharacterized protein C19orf81 C19orf81 Homo sapiens (Human) WLIAVTDFQTR 1 5.6 0.92872 -0.47332 0 0 0 0 0 0 0 0 0 0 0 12.9266 C9JBD0 KRBX1_HUMAN KRAB domain-containing protein 1 KRBOX1 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] AGWIGYLELRRYTYLAK 1 13.3 0.9658 -1.1263 0 0 0 0 8.21398 0 0 0 0 0 0 0 C9JL84 HHLA1_HUMAN HERV-H LTR-associating protein 1 HHLA1 Homo sapiens (Human) extracellular region [GO:0005576] MLGFLSR 1 1.3 0.90984 -0.31659 0 0 0 0 0 0 0 0 9.16169 0 0 0 C9JLR9 ZFTA_HUMAN Zinc finger translocation-associated protein (ZFTA) ZFTA C11orf95 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] HGMVCMVCGSSLATLK;LEYLMDFNPAR;RHILQVHPFSMDFTPEER 3 6.6 0.098784 0.36989 0 6.7761 0 0 0 8.44861 0 0 0 0 7.22178 0 C9JLW8 MCRI1_HUMAN Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) MCRIP1 FAM195B GRAN2 Homo sapiens (Human) regulation of epithelial to mesenchymal transition [GO:0010717] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634] GLVEEYVEK;MTSSPVSRVVYNGKR 2 24.7 0.97545 -1.4543 0 0 0 9.41105 0 0 0 0 0 0 0 0 C9JN71 ZN878_HUMAN Zinc finger protein 878 ZNF878 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IHERTHTGEKPFECK;KWNNQYIEDEHQNPR 2 5.6 0.68147 0.1647 0 8.46789 0 0 7.9421 5.77109 0 0 0 0 0 0 C9JQI7 TM232_HUMAN Transmembrane protein 232 TMEM232 Homo sapiens (Human) cell projection organization [GO:0030030]; flagellated sperm motility [GO:0030317]; maintenance of protein complex location [GO:0098544]; spermatid cytoplasm removal during spermiation of flagellated sperm [GO:0160087]; spermatogenesis [GO:0007283] membrane [GO:0016020]; outer dense fiber [GO:0001520] EDAICKAQELKDK;EEKLHKQTKPYELPYR;IIDHHWQEELK;SSQKNILYLDK 4 7.8 0.9338 -0.50513 7.57524 0 0 9.41219 8.75932 0 0 0 9.49444 0 0 0 C9JR72 KBTBD_HUMAN Kelch repeat and BTB domain-containing protein 13 KBTBD13 Homo sapiens (Human) actin filament organization [GO:0007015]; protein ubiquitination [GO:0016567]; regulation of the force of skeletal muscle contraction [GO:0014728]; relaxation of skeletal muscle [GO:0090076] cytosol [GO:0005829] actin filament binding [GO:0051015] LLREKAGFPRPGSLQTFLLR 1 4.4 0.46216 0.19077 6.14057 0 0 0 0 0 0 0 0 0 0 0 C9JSJ3 MEIOS_HUMAN Meiosis initiator protein (Basic helix-loop-helix and HMG box domain-containing protein 1) MEIOSIN BHMG1 Homo sapiens (Human) activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] KNHTSKLQELALLLPIALK;LQELALLLPIALKTGTK;NQRNQNK 3 4.7 0.97229 -2.6848 0 0 0 0 9.45333 0 0 10.8015 0 0 0 0 C9JXX5 FREY_HUMAN Protein Frey 1 (Frey regulator of sperm-oocyte fusion 1) (FREY1) FREY1 C11orf94 FREY Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein-containing complex assembly [GO:0065003]; sperm-egg recognition [GO:0035036] endoplasmic reticulum membrane [GO:0005789] protein-macromolecule adaptor activity [GO:0030674] VLAMLGALHPRAGLSLFLHLILAVALLRSQPLR 1 33.7 0.57902 0.18087 0 0 0 0 0 0 0 0 0 3.43429 0 0 D3DTV9 PRAC2_HUMAN "Putative protein PRAC2 (Prostate, rectum and colon expressed gene protein 2)" PRAC2 C17orf93 HOXB-AS5 HOXB13-AS1 NCRNA00253 Homo sapiens (Human) nucleus [GO:0005634] WKPVAPR 1 7.8 0.91451 -0.3362 0 0 0 0 0 0 0 0 0 0 5.44827 0 D6REC4 CFA99_HUMAN Cilia- and flagella-associated protein 99 CFAP99 Homo sapiens (Human) motile cilium [GO:0031514] CIETVIEQLDK;LNTTAILR;QAALLHVSAPRTARPKPR;QVEQELQR;RCELISQLRALETQPTR;TARPKPR 6 9.6 0.97878 -1.9857 7.90364 0 0 0 0 0 0 12.9731 10.6409 10.3754 7.57871 0 D6RGH6 MCIN_HUMAN Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) MCIDAS IDAS MCI MCIN Homo sapiens (Human) centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cilium assembly [GO:1902017]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346] nuclear body [GO:0016604]; nucleus [GO:0005634] identical protein binding [GO:0042802] IRSHSTIR 1 2.1 0.98057 -1.6109 0 0 0 0 10.2748 0 0 0 0 0 0 0 D6RIA3 CD054_HUMAN Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) C4orf54 FOPV Homo sapiens (Human) AGVVLRGAPIER;ETEGARGSERQR;GAPIERLQR;GGGGGGAGDGTECR;GSELSPMVAEPSSK;REEQAPIGK;SASETVK;SGSNLEK;SLYIPPVHKDVER 9 5.1 0.97268 -2.6209 13.3822 13.0218 13.3455 13.19 0 0 13.9663 10.3412 0 6.79481 0 0 E2RYF7 PBMU2_HUMAN Protein PBMUCL2 (HLA complex group 22) (Panbronchiolitis-related mucin-like protein 2) HCG22 G2 PBMUCL2 Homo sapiens (Human) extracellular region [GO:0005576] MPRYVPLLLLLLLLR;PRYVPLLLLLLLLR 2 6 0.88843 -0.20339 0 0 0 3.2159 0 0 0 9.46756 0 0 0 0 E5RHQ5 NPB11_HUMAN Nuclear pore complex-interacting protein family member B11 NPIPB11 Homo sapiens (Human) membrane [GO:0016020] DLPSVSSLPFHPQLHPQQMIISR;VVITLWIVYLWVSLLK;YLLSICGFRFHRQR 3 4.6 0.10015 0.36955 8.10486 0 0 6.34037 7.83498 0 0 0 8.75295 11.3396 0 0 E5RJM6 ANR65_HUMAN Ankyrin repeat domain-containing protein 65 ANKRD65 Homo sapiens (Human) GASAAAR;GASPTLR;LAVLELLAAGGAGLDGALLVAAAAGR 3 10 0.20358 0.33126 10.7006 0 8.96099 0 0 3.8518 0 9.80042 6.54153 0 0 0 E7ERA6 RN223_HUMAN RING finger protein 223 RNF223 Homo sapiens (Human) protein ubiquitination [GO:0016567] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] SPSSAGSPR 1 3.6 0.91729 -0.35359 0 0 0 0 0 0 0 9.35513 0 0 0 0 E7EW31 PROB1_HUMAN Proline-rich basic protein 1 PROB1 C5orf65 Homo sapiens (Human) nucleoplasm [GO:0005654] LSVSAQNSR;LTALAPPALPGIPR;SPPFECRIPSEVPSR 3 3.7 0.96314 -1.099 0 0 0 5.48597 0 0 0 10.1714 0 0 8.72656 11.4531 E9PAV3 NACAM_HUMAN "Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)" NACA Homo sapiens (Human) protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] DNA binding [GO:0003677]; unfolded protein binding [GO:0051082] DIELVMSQANVSR;GGLATPPPK;IEDLSQQAQLAAAEK;NNSNDIVNAIMELTM 4 2.9 0 13.165 8.62194 11.1877 0 0 0 0 0 0 0 10.1511 0 0 E9PRG8 CK098_HUMAN Uncharacterized protein C11orf98 C11orf98 Homo sapiens (Human) MGAPGGK 1 5.7 0.71062 0.15645 0 0 0 0 10.2222 0 9.94243 10.6635 0 8.98371 0 0 F5GYI3 UBA1L_HUMAN Ubiquitin-associated protein 1-like (UBAP-1L) UBAP1L Homo sapiens (Human) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] LELAGAR 1 1.8 0.91528 -0.34573 0 0 0 0 0 8.19436 0 0 10.4204 0 0 0 F5H4A9 CC080_HUMAN Uncharacterized membrane protein C3orf80 C3orf80 Homo sapiens (Human) membrane [GO:0016020] GGVAAEPDGGEGR;LSGLLILLVLFAIGYFLQRIICPSPR 2 15.8 0.91054 -0.28169 0 0 0 0 8.23189 0 0 8.33557 0 0 0 0 F5H4B4 F227A_HUMAN Protein FAM227A FAM227A Homo sapiens (Human) ETEVEHFFPLTSKP;GSELRHAR;MNHFRKMEVINLTTLPMIPVDEHLAVSLVAR;YQPNKELQNNLFDR 4 11.8 0.97829 -1.9424 0 0 0 0 4.15202 0 0 7.35755 12.0215 6.5741 0 0 G3V211 CL079_HUMAN Uncharacterized protein encoded by LINC01619 LINC01619 C12orf79 Homo sapiens (Human) STNCILR;VSSAWINWRL 2 17.7 0.93199 -0.49389 0 0 0 0 0 0 0 7.79181 0 0 0 0 G5E9R7 KR416_HUMAN Putative keratin-associated protein 4-16 (Keratin-associated protein 4 pseudogene 1) (Keratin-associated protein 4-16 pseudogene) KRTAP4-16 KRTAP4-16P KRTAP4P1 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] MCSSKMPCSPSASSLCAASPPNCCHPSCCQTTCCR 1 14.9 0.81281 -0.0081979 4.75953 0 0 0 0 0 0 0 0 0 0 0 H0UI37 TSTD3_HUMAN Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 (Rhodanese domain-containing protein 3) TSTD3 Homo sapiens (Human) DFKEKYNEVKPSK 1 13.4 0.86881 -0.093965 0 0 0 0 0 7.17572 8.51483 0 0 0 0 0 H0Y7S4 PRA26_HUMAN PRAME family member 26 PRAMEF26 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AELMKRVR;LPLRPLIK;RLPLRPLIK;SFYDLEADQYCC;TLDEHLTCLLLWVKQRK;WVLPILTQFTPYLGHMRNLQK 6 14 0.91643 -0.41666 0 0 0 0 0 0 0 0 0 0 6.59018 0 H0YL14 TM250_HUMAN Transmembrane protein 250 (Herpes virus UL25-binding protein) TMEM250 C9orf69 Homo sapiens (Human) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of viral process [GO:0048524]; protein localization [GO:0008104] cell division site [GO:0032153]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940] GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] LSVLLLLLGRR;LSVLLLLLGRRR 2 8.6 0.061667 0.4353 7.0054 4.60668 0 0 0 0 0 2.76135 0 0 0 0 H0YM25 GG6LV_HUMAN Golgin subfamily A member 6-like protein 22 GOLGA6L22 Homo sapiens (Human) DLISRLHDSWK;EQEEKMRR;EQEEKRQEQEEK;KADRYIEELTK;LQEKLQLVESEKSEIQLNVK;MWEQEEK;QEEKIREQEEIWR;TELQMALYYSQHAVK 8 14.2 0.97568 -3.319 7.4801 0 9.66 9.4463 9.07288 5.31372 8.6664 10.9172 6.43237 0 10.2025 0 H3BNL8 ARMD2_HUMAN Armadillo-like helical domain-containing protein 2 ARMH2 C6orf229 Homo sapiens (Human) RAQAAQK 1 3 0.91795 -0.40818 0 0 0 9.95361 0 0 0 0 0 0 0 0 H3BPM6 MKROS_HUMAN MKRN2 opposite strand protein (MKRN2 antisense RNA 1) (MKRN2 antisense gene protein 1) MKRN2OS C3orf83 MKRN2-AS1 Homo sapiens (Human) HCAEAGKALIKFNHCEK 1 7.6 0.86419 -0.083961 0 0 0 0 4.95694 0 0 0 0 0 0 0 H3BQJ8 LY6L_HUMAN Lymphocyte antigen 6L (Lymphocyte antigen 6 complex locus protein L) LY6L Homo sapiens (Human) plasma membrane [GO:0005886]; side of membrane [GO:0098552] WALRGGLLLQVGLSLLRALL 1 14.5 0.85189 -0.079704 0 0 0 2.39731 0 0 0 0 0 0 0 0 H3BSY2 GOG8M_HUMAN Golgin subfamily A member 8M GOLGA8M Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] AKRVLEVQLQTLNIQK;SSVFLFLQEKK 2 7.3 0.11834 0.35989 0 8.67352 0 4.72318 0 0 0 0 0 0 0 0 H3BUK9 POTB2_HUMAN POTE ankyrin domain family member B2 POTEB2 Homo sapiens (Human) GSGTSNVGTSGDHDDSFMK;WCCHCFPCCR;WCCHCFPCCRGSGK 3 6.1 0.64817 0.17037 0 0 0 4.1688 0 0 0 0 0 0 0 0 H3BV12 GOG8Q_HUMAN Golgin subfamily A member 8Q GOLGA8Q Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] AERELEVQIQTLIIQK;DLAVRLQHSLQCK;ELERVAGELQSQVK;ELEVQIQTLIIQKEELNTDLYHMERSLR;LQHSLQCK;MSKMLQEICTLK 6 11.1 0.97426 -2.4558 0 6.09386 11.2863 0 8.80829 0 9.9857 6.96532 0 0 6.95942 0 H7BZ55 CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 CROCC2 Homo sapiens (Human) centriole [GO:0005814]; centrosome [GO:0005813] AAGQEKR;AEVSLEPLRQMEQETLKR;ALAEAEEGQRR;ELWAAQK;LDQACHR;LKSEGVEQR;LLEEQLTNLEHRCQKAEVSLEPLR;QTRSGGLGQPR;SEGVEQRDSLAAMAALMEGLAQDK;SGGLGQPR 10 6.2 0.97614 -5.0519 9.84372 12.2972 12.59 0 0 7.69118 0 11.072 0 9.37632 8.88728 0 H7C241 CLD34_HUMAN Claudin-34 CLDN34 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] TNSTTTKFCYR 1 5.1 0.97637 -1.4787 0 0 0 0 0 0 11.1158 0 0 0 0 0 I1YAP6 TRI77_HUMAN Tripartite motif-containing protein 77 TRIM77 TRIM77P Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EEEQKHVESLAREGR;FCSPCLCLLWEDTLTPNCCPVCR;LAMPQPVNPQLSAWTITGVSERLNFFR;VYITLDR 4 16 0.95177 -0.68383 0 0 0 3.27583 0 0 0 7.96895 7.51609 0 0 7.49273 I3L0S3 PYAS1_HUMAN Putative uncharacterized protein PYCARD-AS1 (PYCARD antisense RNA 1) (PYCARD antisense gene protein 1) (PYCARD opposite strand protein) PYCARD-AS1 C16orf98 PYCARDOS Homo sapiens (Human) GGTWTPRLPPTLVSR 1 7.4 0.91567 -0.43194 0 0 0 0 0 6.09951 0 0 0 0 0 0 I6L899 GOG8R_HUMAN Golgin subfamily A member 8R GOLGA8R Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] DLAVRLQHSLQCK;ELERVAGELQSQVK;LQHSLQCK;QKAERVLEVQIQTLIIQK 4 7.1 0.86229 -0.083025 0 0 0 6.51494 0 0 0 0 6.93687 0 0 0 I6L899 GOG8R_HUMAN Golgin subfamily A member 8R GOLGA8R Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] ELERVAGELQSQVK;LGEVKETETSTPSK 2 9.5 0.88205 -0.17625 0 0 11.0129 0 0 0 0 0 0 0 0 0 J3KSC0 CR064_HUMAN Putative uncharacterized protein encoded by LINC01387 LINC01387 C18orf64 Homo sapiens (Human) IQPSQQDGGPPK 1 8.9 0.89664 -0.23757 0 0 0 0 9.00284 0 0 0 0 0 0 0 K9M1U5 IFNL4_HUMAN Interferon lambda-4 (IFN-lambda-4) IFNL4 Homo sapiens (Human) cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of immune response [GO:0050778]; type III interferon-mediated signaling pathway [GO:0038196]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasm [GO:0005737]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102] GIADAQAVLSGLHRSELLPGAGPILELLAAAGR 1 19.4 0.83376 -0.027261 0 4.92529 0 0 0 0 0 0 0 0 0 0 M0QZC1 RN225_HUMAN RING finger protein 225 RNF225 Homo sapiens (Human) protein ubiquitination [GO:0016567] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] TLDRRSDGTWGTEAGPGWAPWPR 1 7 0.59296 0.17852 0 0 0 0 0 0 0 0 8.57452 0 0 0 M0R2J8 DCDC1_HUMAN Doublecortin domain-containing protein 1 (Doublecortin domain-containing 5 protein) DCDC1 DCDC5 KIAA1493 Homo sapiens (Human) cell division [GO:0051301]; intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] cytoplasm [GO:0005737]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686] carbohydrate binding [GO:0030246]; microtubule binding [GO:0008017] DLGSDSPIQTDHMMER;GKEIFALKDLQR;IQIFCSTHK;QIFLRNLESDIAKIQIFCSTHK;TQCTEILNLPSAARRLYNEK;VTAYKNGSR 6 4.4 0.95174 -0.69915 6.66306 12.1312 11.7177 0 0 0 0 0 0 8.1821 0 0 M5A8F1 SUPYN_HUMAN Suppressyn (Endogenous retrovirus group 48 member 1) (NDUFV3 antisense RNA 1) (endogenous retrovirus group Fb member 1) ERVH48-1 C21orf105 HERV-Fb1 NDUFV3-AS1 Homo sapiens (Human) syncytium formation [GO:0006949] extracellular space [GO:0005615] ECYQSLHYR 1 5.6 0.8482 -0.066566 0 0 6.6737 0 0 0 0 0 0 0 0 0 O00110 OVOL3_HUMAN Putative transcription factor ovo-like protein 3 OVOL3 Homo sapiens (Human) epidermal cell differentiation [GO:0009913]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" THTGIRPFRCSACGKAFTQR 1 10.5 0.85114 -0.079704 0 0 0 0 0 0 3.88577 0 0 0 0 0 O00116 ADAS_HUMAN "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase)" AGPS AAG5 Homo sapiens (Human) ether lipid biosynthetic process [GO:0008611]; lipid biosynthetic process [GO:0008610] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949] DRDPDPDR;QRCAPASIRLMDNK 2 3.3 0.97265 -2.6723 0 0 0 0 10.5926 0 0 0 0 0 10.6548 0 O00139 KIF2A_HUMAN Kinesin-like protein KIF2A (Kinesin-2) (hK2) KIF2A KIF2 KNS2 Homo sapiens (Human) cell differentiation [GO:0030154]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; regulation of cell migration [GO:0030334] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] SHAVFQIILRR 1 1.6 0.93419 -0.50378 0 0 0 0 8.77591 0 0 0 0 0 0 0 O00141 SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) SGK1 SGK Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuron projection morphogenesis [GO:0048812]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of catalytic activity [GO:0050790]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of gastric acid secretion [GO:0060453]; regulation of signal transduction by p53 class mediator [GO:1901796]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; sodium channel regulator activity [GO:0017080] ARLESLLRPR 1 2.2 0.9808 -1.6247 0 0 0 0 0 0 0 0 0 9.5224 0 0 O00141 SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) SGK1 SGK Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuron projection morphogenesis [GO:0048812]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of catalytic activity [GO:0050790]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of gastric acid secretion [GO:0060453]; regulation of signal transduction by p53 class mediator [GO:1901796]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; sodium channel regulator activity [GO:0017080] MSSQSSSLSEACSR 1 3.1 0.9348 -0.53038 10.2085 0 10.0641 9.56073 9.70896 0 0 8.8888 0 9.09173 12.1147 0 O00142 KITM_HUMAN "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK)" TK2 Homo sapiens (Human) deoxycytidine metabolic process [GO:0046092]; DNA biosynthetic process [GO:0071897]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; deoxynucleoside kinase activity [GO:0019136]; nucleoside kinase activity [GO:0019206]; thymidine kinase activity [GO:0004797] SVVLTEPVSKWR 1 5 0.83529 -0.031481 0 6.21467 0 0 0 0 0 0 0 0 0 0 O00144 FZD9_HUMAN Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349) FZD9 FZD3 Homo sapiens (Human) B cell differentiation [GO:0030183]; bone regeneration [GO:1990523]; canonical Wnt signaling pathway [GO:0060070]; learning or memory [GO:0007611]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of necroptotic process [GO:0060546]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904394]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; non-canonical Wnt signaling pathway [GO:0035567]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neural precursor cell proliferation [GO:2000179]; postsynapse organization [GO:0099173]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; release of cytochrome c from mitochondria [GO:0001836] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; filopodium membrane [GO:0031527]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] GIGYNLTR;LNMDFWRLR;TFQTWQSLCYRK;TIVILTLRK 4 6.4 0.96564 -1.2455 0 0 0 10.4287 8.16897 0 0 9.88203 0 8.07119 10.9741 0 O00148 DX39A_HUMAN ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) DDX39A DDX39 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of innate immune response [GO:0045824]; negative regulation of RNA export from nucleus [GO:0046832]; RNA export from nucleus [GO:0006405]" cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DVQEIFR;GLAITFVSDENDAK;ILNDVQDR;ILVATNLFGR;VSVFFGGLSIKK 5 11.9 0.6741 0.16689 10.3572 0 0 0 0 0 0 0 0 0 0 0 O00154 BACH_HUMAN Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase) ACOT7 BACH Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; coenzyme A biosynthetic process [GO:0015937]; fatty acid catabolic process [GO:0009062]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; protein homodimerization activity [GO:0042803] ATLWYVPLSLK;LMDEVAGIVAAR;QGHAEPQP 3 8.2 0.96646 -1.2815 0 0 0 0 0 0 0 7.96918 0 0 0 8.75164 O00159 MYO1C_HUMAN Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to type II interferon [GO:0071346]; chromatin remodeling [GO:0006338]; endocytosis [GO:0006897]; positive regulation of cell migration [GO:0030335]; positive regulation of cellular response to insulin stimulus [GO:1900078]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; protein targeting to membrane [GO:0006612]; regulation of bicellular tight junction assembly [GO:2000810]; vascular endothelial growth factor signaling pathway [GO:0038084]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; B-WICH complex [GO:0110016]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; stereocilium membrane [GO:0060171]; unconventional myosin complex [GO:0016461] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] LGTDEISPR;NLKETMCSSK;VTMESALTAR;YLGLLENLRVRR 4 3.9 0.97719 -2.2304 0 0 0 0 0 0 0 0 10.2198 11.9094 10.393 0 O00161 SNP23_HUMAN Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) SNAP23 Homo sapiens (Human) exocytosis [GO:0006887]; histamine secretion by mast cell [GO:0002553]; membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903] adherens junction [GO:0005912]; azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; tertiary granule membrane [GO:0070821] SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] CCGLCVCPCNR;ETEKTLTELNK;ITDKADTNR 3 14.7 0.97325 -2.4948 0 0 0 0 0 0 0 11.4006 0 0 0 0 O00186 STXB3_HUMAN Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) STXBP3 Homo sapiens (Human) brain development [GO:0007420]; cellular response to type II interferon [GO:0071346]; insulin secretion [GO:0030073]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of D-glucose import [GO:0046325]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820] protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] DRSAEETFQLSRWTPFIK;IMLLDEFTTK;KLEDYYKIDEK;VLLPVLLNK 4 8.1 0.98028 -2.0178 0 0 3.63819 9.70274 0 0 13.4424 0 0 0 0 0 O00192 ARVC_HUMAN Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) ARVCF Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296] GLGMRPPR;GLPVLVELLQSETDKVVR;GVPALVALVASSQSVR;HVALQLER;LTRALEQER;VRQLRGLPLLVALLDHPR 6 8 0.97294 -2.5018 0 4.65375 0 0 0 0 3.97407 0 0 9.92935 0 8.21106 O00193 SMAP_HUMAN Small acidic protein SMAP C11orf58 Homo sapiens (Human) INEELESQYQQSMDSK;LMGAGKK;LSGRYRR;LVIGDHK 4 20.2 0.97458 -3.0949 0 0 0 0 11.0016 0 0 0 0 0 7.88521 0 O00194 RB27B_HUMAN Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG) RAB27B Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; exocytosis [GO:0006887]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; synaptic vesicle endocytosis [GO:0048488] apical plasma membrane [GO:0016324]; axon cytoplasm [GO:1904115]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network transport vesicle [GO:0030140]; zymogen granule membrane [GO:0042589] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904] FNPKFITTVGIDFREK;YTDNKFNPK 2 9.6 0.97307 -2.5008 0 0 0 0 9.41764 0 11.6274 0 0 0 0 0 O00203 AP3B1_HUMAN AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) AP3B1 ADTB3A Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; establishment of protein localization to mitochondrial membrane involved in mitochondrial fission [GO:0090152]; granulocyte differentiation [GO:0030851]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; intracellular zinc ion homeostasis [GO:0006882]; lung morphogenesis [GO:0060425]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mRNA transcription by RNA polymerase II [GO:0042789]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cell surface [GO:0034394]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; respiratory system process [GO:0003016]; single fertilization [GO:0007338]; skin epidermis development [GO:0098773]; spermatogenesis [GO:0007283]; toll-like receptor signaling pathway [GO:0002224]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvesicle [GO:1990742]; mitochondrion [GO:0005739] GTP-dependent protein binding [GO:0030742]; protein phosphatase binding [GO:0019903] GLAAHYFFPRQPCIFGDK;IVGMIAKGK;LYLTNSK 3 3.1 0.97973 -2.0019 0 0 0 0 0 0 12.3646 0 0 0 0 0 O00204 ST2B1_HUMAN Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) SULT2B1 HSST2 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of epidermal cell differentiation [GO:0045606]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] cholesterol binding [GO:0015485]; cholesterol sulfotransferase activity [GO:0051922]; nucleic acid binding [GO:0003676]; small molecule binding [GO:0036094]; steroid hormone binding [GO:1990239]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] IAGQLKDPGTPDQFLRDFLK 1 5.5 0.46237 0.19077 0 0 0 0 0 0 0 0 0 0 10.605 0 O00206 TLR4_HUMAN Toll-like receptor 4 (hToll) (CD antigen CD284) TLR4 Homo sapiens (Human) astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; detection of fungus [GO:0016046]; detection of lipopolysaccharide [GO:0032497]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; MHC class II biosynthetic process [GO:0045342]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide production involved in inflammatory response [GO:0002537]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phagocytosis [GO:0006909]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of dendritic cell cytokine production [GO:0002730]; response to lipopolysaccharide [GO:0032496]; stress-activated MAPK cascade [GO:0051403]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; wound healing involved in inflammatory response [GO:0002246] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle [GO:0001726] "amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]" AGIIFIVLQKVEKTLLR;KVIVVVSQHFIQSR 2 3.7 0.93739 -0.56115 0 0 0 0 5.20582 0 0 0 0 0 0 0 O00212 RHOD_HUMAN Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1) RHOD ARHD Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901] SVGAVAYLECSAR 1 6.2 0.93663 -0.52377 0 0 0 0 0 0 10.1861 0 0 0 0 0 O00213 APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) APBB1 FE65 RIR Homo sapiens (Human) apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle receptor binding [GO:0050750]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] NIATSLHEICSKIMAER;VGWTVRR 2 3.4 0.91697 -0.41117 0 0 0 0 0 0 0 6.6844 0 0 8.83349 0 O00214 LEG8_HUMAN Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) cellular response to virus [GO:0098586]; lymphatic endothelial cell migration [GO:1904977]; xenophagy [GO:0098792] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; integrin binding [GO:0005178] FQVDLQNGSSMKPR;SGTPQLPSNRGGDISK 2 8.4 0.91783 -0.40836 0 0 0 0 0 5.19527 0 0 11.6838 0 8.43471 0 O00219 HYAS3_HUMAN Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3) HAS3 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluranon cable assembly [GO:1900106] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hyaluranon cable [GO:0036117]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] CLTETPTK;GRIWNILLFLLTVQLVGIIK;WGGKREVMYTAFK 3 7.4 0.95566 -0.80853 0 11.9105 0 0 11.0471 9.85815 0 0 0 12.7186 12.7428 10.5113 O00221 IKBE_HUMAN NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) NFKBIE IKBE Homo sapiens (Human) cytoplasmic sequestering of transcription factor [GO:0042994] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] AGPSEPHSPGR;EDADGER;GGGGAIR;ISGKLLLCTD 4 7 0.9815 -1.7711 0 8.32382 0 0 3.96818 0 0 0 0 8.089 5.96327 9.85943 O00222 GRM8_HUMAN Metabotropic glutamate receptor 8 (mGluR8) GRM8 GPRC1H MGLUR8 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]" plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642] GVPCGELKK;IARDSSYEQEGK;TVKGVPCCWHCER;VEDMQWAHR 4 4.7 0.95381 -0.9239 0 0 8.15294 0 9.25621 0 10.1861 10.1453 0 6.71918 0 0 O00231 PSD11_HUMAN 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) PSMD11 Homo sapiens (Human) proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stem cell differentiation [GO:0048863]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" structural molecule activity [GO:0005198] AAAAVVEFQR;CVAQASKNR;EQSILELGSLLAK;SLADFEKALTDYR;TGQAAELGGLLK;VIEPFSRVQIEHISSLIKLSK;VVDSLYNK 7 20.4 0.37762 0.21838 0 0 9.35293 9.72231 10.1001 0 0 9.22629 0 8.74359 10.2676 0 O00232 PSD12_HUMAN 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) PSMD12 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" IVKMEVDYSATVDQR;MADGGSERADGR;TIFAKVDR;VEFILEQMR;YYNLMIQLDQHEGSYLSICK 5 14 0.97328 -2.5767 0 0 0 0 0 0 0 0 0 0 9.65982 8.92724 O00233 PSMD9_HUMAN 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) PSMD9 Homo sapiens (Human) negative regulation of insulin secretion [GO:0046676]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; proteasome regulatory particle assembly [GO:0070682]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome regulatory particle [GO:0005838] bHLH transcription factor binding [GO:0043425]; transcription coactivator activity [GO:0003713] HQLRLVPTR 1 4 0.98092 -1.6073 0 0 0 10.6986 0 0 0 0 0 0 0 0 O00237 RN103_HUMAN E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103) RNF103 ZFP103 Homo sapiens (Human) central nervous system development [GO:0007417]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein ubiquitination [GO:0016567] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] TGTFNCSSDPR 1 1.6 0.80747 0.010594 0 0 0 0 0 0 0 4.12027 0 0 0 0 O00238 BMR1B_HUMAN Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293) BMPR1B Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte development [GO:0002063]; dorsal/ventral pattern formation [GO:0009953]; endochondral bone morphogenesis [GO:0060350]; eye development [GO:0001654]; inflammatory response [GO:0006954]; negative regulation of chondrocyte proliferation [GO:1902731]; osteoblast differentiation [GO:0001649]; ovarian cumulus expansion [GO:0001550]; ovulation cycle [GO:0042698]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290] dendrite [GO:0030425]; HFE-transferrin receptor complex [GO:1990712]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; transmembrane signaling receptor activity [GO:0004888]" LRPSFPNRWSSDECLR 1 3.2 0.95106 -0.66925 0 0 0 0 9.58088 0 0 0 0 0 0 0 O00241 SIRB1_HUMAN Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b) SIRPB1 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] VTTVSELTK 1 2.3 0.92062 -0.44638 0 0 0 0 9.54828 0 0 0 0 0 0 0 O00244 ATOX1_HUMAN Copper transport protein ATOX1 (Metal transport protein ATX1) ATOX1 HAH1 Homo sapiens (Human) copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; metallochaperone activity [GO:0016530] TVSYLGLE 1 11.8 0.78346 0.023663 0 0 0 0 0 0 0 0 0 0 8.33967 0 O00255 MEN1_HUMAN Menin MEN1 SCG2 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to UV [GO:0009411]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]" chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; Y-form DNA binding [GO:0000403] KVSDVIWNSLSRSYFK;LQLTAQSQVQMKK 2 4.8 0.74509 0.093097 3.23222 0 0 0 0 0 0 0 6.36222 0 0 0 O00257 CBX4_HUMAN E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) CBX4 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein sumoylation [GO:0016925] nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; methylated histone binding [GO:0035064]; phosphoprotein binding [GO:0051219]; single-stranded RNA binding [GO:0003727]; SUMO binding [GO:0032183]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] EAVTGNGIGGK;QEQLMGYRKR 2 3.8 0.9159 -0.3907 0 0 9.09566 0 0 0 0 0 0 11.9284 0 0 O00264 PGRC1_HUMAN Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) PGRMC1 HPR6.6 PGRMC Homo sapiens (Human) heme biosynthetic process [GO:0006783]; positive regulation of lipoprotein transport [GO:0140077]; positive regulation of protein localization to plasma membrane [GO:1903078] cell body [GO:0044297]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; specific granule membrane [GO:0035579]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; steroid binding [GO:0005496] DFTPAELR;FDGVQDPR;ILMAINGK;KFYGPVKYHHVGK;VFDVTKGR 5 31.5 0.97084 -1.3364 0 0 4.15518 0 0 0 0 0 11.7608 0 0 0 O00267 SPT5H_HUMAN Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) SUPT5H SPT5 SPT5H Homo sapiens (Human) "negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]" DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] IDYDRIKAR;IGEERATAISLMRK;LVENGGMFVCK 3 3.1 0.98019 -1.5641 0 9.1417 7.93328 0 0 0 0 0 0 0 0 0 O00268 TAF4_HUMAN Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) TAF4 TAF2C TAF2C1 TAF4A TAFII130 TAFII135 Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; ovarian follicle development [GO:0001541]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] chromatin [GO:0000785]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] KVDCPGPGSGAEGSGPGSVVPGSSGVGTPR 1 2.8 0.37832 0.22142 0 0 0 0 0 0 0 0 0 0 0 9.57716 O00270 GPR31_HUMAN "12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (GPR31/12-HETER)" GPR31 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of inflammatory response [GO:0050728]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]; response to molecule of bacterial origin [GO:0002237] plasma membrane [GO:0005886] arachidonate binding [GO:0050544]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930] EPEKQPK 1 2.2 0.98043 -1.6404 0 0 0 0 0 10.7099 0 0 0 0 0 0 O00273 DFFA_HUMAN DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) DFFA DFF1 DFF45 H13 Homo sapiens (Human) apoptotic DNA fragmentation [GO:0006309]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of deoxyribonuclease activity [GO:0032076]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; thymocyte apoptotic process [GO:0070242] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] deoxyribonuclease inhibitor activity [GO:0060703]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183] AAFGEEVDAVDTGISR;TETVQEACERELALR 2 9.4 0.94585 -0.65572 0 0 0 0 8.4955 0 0 0 0 0 8.72178 0 O00291 HIP1_HUMAN Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) HIP1 Homo sapiens (Human) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; neurotransmitter receptor transport [GO:0099637]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of receptor-mediated endocytosis [GO:0048260]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] "actin filament binding [GO:0051015]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; epidermal growth factor receptor binding [GO:0005154]; glutamate receptor binding [GO:0035254]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]" MWGHLSEGYGQLCSIYLKLLR 1 2 0.95328 -0.67418 0 0 0 0 0 0 6.69195 6.84436 0 0 0 0 O00292 LFTY2_HUMAN Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4) LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024 Homo sapiens (Human) anterior/posterior axis specification [GO:0009948] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160] EVAGRFLASEAALHR;TRPQVVSLPNMR 2 8.1 0.91747 -0.42143 3.79649 0 0 0 0 0 0 0 10.6897 0 0 0 O00294 TULP1_HUMAN Tubby-related protein 1 (Tubby-like protein 1) TULP1 TUBL1 Homo sapiens (Human) "dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]" axon terminus [GO:0043679]; cell projection [GO:0042995]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AKAQGPR;EKILLPPKKPLR;ILLPPKKPLR;ILLPPKKPLREK 4 3.9 0.9795 -1.8488 0 2.34298 0 0 0 8.23419 0 0 0 7.21713 0 0 O00295 TULP2_HUMAN Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2) TULP2 TUBL2 Homo sapiens (Human) protein localization to cilium [GO:0061512]; visual perception [GO:0007601] cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] protein-containing complex binding [GO:0044877] GLGNPFLR 1 1.5 0.91294 -0.39033 0 0 0 0 0 0 0 10.7961 0 0 0 0 O00299 CLIC1_HUMAN Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) CLIC1 G6 NCC27 Homo sapiens (Human) chloride transport [GO:0006821]; platelet aggregation [GO:0070527]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of mitochondrial membrane potential [GO:0051881]; signal transduction [GO:0007165] blood microparticle [GO:0072562]; brush border [GO:0005903]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982] cadherin binding [GO:0045296]; chloride channel activity [GO:0005254]; oxidoreductase activity [GO:0016491] AEEQPQVELFVK;GFTIPEAFR;LAALNPESNTAGLDIFAK;NSNPALNDNLEK;VLDNYLTSPLPEEVDETSAEDEGVSQR;YLSNAYAR 6 35.7 0 45.624 13.5447 13.6668 13.965 12.2538 12.5314 11.4384 8.89893 9.39618 11.9052 11.8692 10.58 12.094 O00300 TR11B_HUMAN Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) TNFRSF11B OCIF OPG Homo sapiens (Human) apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; negative regulation of bone resorption [GO:0045779]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; response to arsenic-containing substance [GO:0046685]; response to estrogen [GO:0043627]; response to magnesium ion [GO:0032026]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine activity [GO:0005125]; heparan sulfate binding [GO:1904399]; signaling receptor activity [GO:0038023] GLMHALK;HIGHANLTFEQLR;RQHSSQEQTFQLLKLWK;SLMESLPGKK 4 11.7 0.97318 -2.591 0 0 0 0 0 0 0 10.6444 8.854 0 0 9.54197 O00308 WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) WWP2 Homo sapiens (Human) extracellular transport [GO:0006858]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein transport [GO:0051224]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; symbiont entry into host cell [GO:0046718]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VTTHELK;YFVDHNTR 2 1.7 0.90843 -0.30949 0 0 8.606 0 0 0 0 0 0 0 0 0 O00311 CDC7_HUMAN Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) CDC7 CDC7L1 Homo sapiens (Human) cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGTPGFR;ELDQQSTTK;EVPAQDLR;EYMLNLFKALKR 4 6.3 0.96519 -1.1485 0 0 8.33253 0 0 0 4.60241 5.14694 0 6.15547 8.48382 0 O00329 PK3CD_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)" PIK3CD Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]" ERVPFILTYDFVHVIQQGK;IGHFLFWHLR;VKKLINSQISLLIGK 3 4.2 0.97666 -2.2027 0 0 7.93021 0 0 0 0 0 0 0 0 12.0275 O00330 ODPX_HUMAN "Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)" PDHX PDX1 Homo sapiens (Human) acetyl-CoA biosynthetic process from pyruvate [GO:0006086] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] acyltransferase activity [GO:0016746] AAAVTLK;VVDDELATR 2 3.2 0.91414 -0.32948 0 0 11.42 9.56388 0 0 0 0 0 0 0 0 O00337 S28A1_HUMAN Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1) SLC28A1 CNT1 Homo sapiens (Human) azole transmembrane transport [GO:0045117]; cytidine transport [GO:0015861]; nucleoside import across plasma membrane [GO:0180015]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transport [GO:0015855]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transmembrane transport [GO:0015862] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] azole transmembrane transporter activity [GO:1901474]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] AVSWGLGLQFVLGLLVIR;HHCAVSWR;LAGAEEWVGDRK 3 5.9 0.87363 -0.11037 8.62169 0 4.72154 0 0 0 0 0 9.91241 0 9.64758 0 O00338 ST1C2_HUMAN Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2) SULT1C2 SULT1C1 Homo sapiens (Human) amine metabolic process [GO:0009308]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764] aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] GTVGDWK;ITDLLPPSFWENNCKFLYVAR;IVQETSFEKMKENPMTNR;SILDQSISSFMRK 4 19.2 0.90889 -0.30128 0 8.32805 0 0 0 6.04656 0 0 10.6171 9.76547 8.78901 0 O00339 MATN2_HUMAN Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; extracellular matrix organization [GO:0030198]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; response to axon injury [GO:0048678] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] DVCQAIDHGCEHICVNSDDSYTCECLEGFR;EDGKTCRR;VGLLQYGSTVKNEFSLKTFK 3 6.1 0.74541 0.093234 0 11.1946 0 0 0 0 0 0 0 0 8.22067 0 O00341 EAA5_HUMAN Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7) SLC1A7 EAAT5 Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; dicarboxylic acid transport [GO:0006835]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504] plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic membrane [GO:0097060] extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175] NGPKGPG 1 4.4 0.74032 0.10655 0 0 0 0 0 0 0 0 0 0 8.99483 0 O00358 FOXE1_HUMAN Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) FOXE1 FKHL15 FOXE2 TITF2 TTF2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; chordate pharynx development [GO:0160093]; cranial skeletal system development [GO:1904888]; embryonic organ morphogenesis [GO:0048562]; hair follicle morphogenesis [GO:0031069]; hard palate development [GO:0060022]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" FPFYRDNPK;GAGGRRR 2 4.3 0.98074 -1.6596 0 0 0 0 0 0 7.96976 0 0 0 0 0 O00370 LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] Homo sapiens (Human) DNA recombination [GO:0006310]; nucleic acid metabolic process [GO:0090304]; retrotransposition [GO:0032197] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; type II site-specific deoxyribonuclease activity [GO:0009036] ALLSKCK;DKIDKWDLIK;DLFKENYKPLLK;DLNVKPK;ELEKQEQTHSK;FIWNQKR;HRLASWIKSQDPSVCCIQETHLTCR;IDKWDLIK;IDTLTSQLKELEK;IDTLTSQLKELEKQEQTHSK;IYQANGK;NKAGGITLPDFKLYYK 12 8.7 0.97653 -5.5055 0 0 10.3915 7.23247 10.9316 0 0 13.0281 12.0934 10.1826 0 10.6515 O00391 QSOX1_HUMAN Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) QSOX1 QSCN6 UNQ2520/PRO6013 Homo sapiens (Human) extracellular matrix assembly [GO:0085029]; negative regulation of macroautophagy [GO:0016242]; protein folding [GO:0006457] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] GYVHYFFGCR;NKIPYSFFK;VGSPNAAVLWLWSSHNR 3 4.8 0.97842 -1.9816 0 0 12.2488 0 0 10.1208 0 0 0 0 0 0 O00398 P2Y10_HUMAN Putative P2Y purinoceptor 10 (P2Y10) (P2Y-like receptor) P2RY10 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FQYSLYATTYILIFIPGLLANSAALWVLCRFISK 1 10 0.81884 -0.017651 0 8.42643 0 0 0 0 0 0 0 0 0 0 O00408 PDE2A_HUMAN "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; heart valve development [GO:0003170]; monocyte differentiation [GO:0030224]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; ventricular septum development [GO:0003281]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]" EPGPPGSR;IDCPTLARFCLMVKK;LKCECQALLQVAK;NILCFPIK;SHLANEMMMYHMK;VLGEEVSFPLTGCLGQVVEDKKSIQLK;VLQYLQQETRASR 7 12.3 0.95203 -0.69451 13.7014 4.69922 5.8845 7.4048 3.58304 0 0 11.7657 0 10.3848 0 0 O00409 FOXN3_HUMAN Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) craniofacial suture morphogenesis [GO:0097094]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GLFPGVRPLPITPIGVTAAMRNGITSCR;SSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFR;VPSDTLPLK 3 16.5 0.96605 -1.2618 10.3081 0 0 0 7.86716 0 0 0 0 0 0 0 O00410 IPO5_HUMAN Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) IPO5 KPNB3 RANBP5 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTPase inhibitor activity [GO:0005095]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] LVLEQVVTSIASVADTAEEK;NQELRQVK;NTTAAEEAR;QMAAVLLR;SLVEIADTVPK;TAGLEEK;VIQSADSK;VQAHAAAALINFTEDCPK 8 8.1 0 9.918 13.3247 9.21157 8.55785 0 13.2071 10.5236 8.09043 0 12.5987 0 0 11.9952 O00411 RPOM_HUMAN "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" POLRMT Homo sapiens (Human) mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] 3'-5'-RNA exonuclease activity [GO:0000175]; DNA primase activity [GO:0003896]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; sequence-specific DNA binding [GO:0043565] LEREVYEGR;MLLQVLQALPAQGESFTTLAR;TLRDQWEK;VLDLVLQLFQAK;VQMGAKDATPVPCGRWAK 5 5.5 0.95516 -0.97959 0 12.196 0 8.0457 0 0 0 10.2582 0 0 0 10.2337 O00418 EF2K_HUMAN Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) EEF2K Homo sapiens (Human) cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; myosin II filament disassembly [GO:0031037]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of translation at postsynapse [GO:0140245]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069] "ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135]" GELDDPEPREHGHSYSNR;LTPQAFSHFTFER;VCVEKWNLLNSSRLHLPR 3 6.8 0.89731 -0.2359 0 0 0 0 6.76235 0 9.08584 0 0 6.03872 6.67101 0 O00421 CCRL2_HUMAN C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor) CCRL2 CCR11 CCR6 CKRX CRAM HCR Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950]; chemokine receptor binding [GO:0042379] EQRYSLFK 1 2.3 0.91392 -0.33804 4.22141 3.03536 0 0 4.49467 0 2.91915 4.77468 0 0 0 10.3252 O00423 EMAL1_HUMAN Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) EML1 EMAP1 EMAPL EMAPL1 Homo sapiens (Human) brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405] cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] EPVFSAEEGYVKMFLR;LISWSGNYQK;LNITEEQQAVLNRK 3 4.9 0.95447 -0.91092 0 0 0 0 0 6.06843 2.60383 0 0 0 5.93218 0 O00425 IF2B3_HUMAN Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) IGF2BP3 IMP3 KOC1 VICKZ3 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] MVIITGPPEAQFK;TVNELQNLSSAEVVVPR 2 5.2 0.045855 0.49838 0 9.86654 0 0 0 0 0 0 0 0 0 0 O00429 DNM1L_HUMAN Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) DNM1L DLP1 DRP1 Homo sapiens (Human) calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion organization [GO:0007005]; mitocytosis [GO:0160040]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; regulation of ATP metabolic process [GO:1903578]; regulation of gene expression [GO:0010468]; regulation of mitophagy [GO:1901524]; regulation of peroxisome organization [GO:1900063]; rhythmic process [GO:0048511] brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] EAADMLK;ELPSAVSRDK;EVDPDGRRTLAVITK;ISREVDPDGRR;LIQDSRRETK;LSAREQR;SQLDINNK;SSKVPSALAPASQEPSPAASAEADGK 8 11.7 0.97626 -5.0325 0 0 0 9.20335 10.0972 0 8.68933 9.99336 0 0 9.23026 11.4324 O00443 P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A Homo sapiens (Human) clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; exocytosis [GO:0006887]; insulin receptor signaling pathway [GO:0008286]; membrane organization [GO:0061024]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; vascular associated smooth muscle contraction [GO:0014829] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]" ARTDLEITDSK;EDKAFLWEK;FDWLDLDPLSKPK;IQVEYGVTGSFK;KICSALDGVETLAITESVK;KTRNPTFNEMLVYSGYSK;LPLKPSLVAKELNIK;NPTFNEMLVYSGYSKETLR;SMERVQSFFQK;TYLLPDNHK;VGEDLRQDMLALQMIKIMDK 11 8.4 0.97336 -2.8967 0 12.539 0 7.86938 10.6007 0 10.951 0 10.6347 0 0 11.7514 O00444 PLK4_HUMAN Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) PLK4 SAK STK18 Homo sapiens (Human) centriole replication [GO:0007099]; cilium assembly [GO:0060271]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; positive regulation of centriole replication [GO:0046601]; protein phosphorylation [GO:0006468]; trophoblast giant cell differentiation [GO:0060707] centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleolus [GO:0005730]; nucleus [GO:0005634]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]; XY body [GO:0001741] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIK 1 3.8 0.3792 0.2189 7.4127 0 0 0 0 0 0 0 7.34119 0 0 0 O00445 SYT5_HUMAN Synaptotagmin-5 (Synaptotagmin V) (SytV) SYT5 Homo sapiens (Human) calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; chemical synaptic transmission [GO:0007268]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; neuronal cell body [GO:0043025]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proximal neuron projection [GO:1990769]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]" DSRTPPPCSR;EEEKLGDICFSLR 2 6 0.97843 -2.0606 0 0 0 0 0 4.57453 0 11.1646 0 0 0 0 O00451 GFRA2_HUMAN GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2) GFRA2 GDNFRB RETL2 TRNR2 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; nervous system development [GO:0007399] external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167]; heparan sulfate binding [GO:1904399] GPSFQATQAPRVEK;LADFHANCR 2 5 0.95552 -0.85619 0 0 0 0 0 0 0 0 0 11.3188 0 0 O00458 IFRD1_HUMAN Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) IFRD1 Homo sapiens (Human) muscle cell differentiation [GO:0042692]; myoblast fate determination [GO:0007518]; negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle tissue development [GO:0014706] nucleus [GO:0005634]; sarcoplasm [GO:0016528] FGPERMYIDCWVK;NALASKMLYEFILERR 2 6.4 0.96709 -1.3099 0 0 0 0 0 0 5.86696 0 0 9.2086 9.63552 0 O00459 P85B_HUMAN Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) PIK3R2 Homo sapiens (Human) B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976]; T cell differentiation [GO:0030217] "cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971] KINEWLGIK 1 1.2 0.77916 0.034695 0 0 0 0 0 0 0 0 0 8.91256 0 0 O00461 GOLI4_HUMAN "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) cis-Golgi network [GO:0005801]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] ELEHNAEETYGENDENTDDK;LEAQETLNK;QAELEEGRPQHQEQLR 3 6.5 0.93775 -0.56954 0 0 0 8.36203 0 0 9.99831 0 0 0 6.39276 0 O00463 TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84) TRAF5 RNF84 Homo sapiens (Human) apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; interleukin-17-mediated signaling pathway [GO:0097400]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] identical protein binding [GO:0042802]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] ELNTVPICPVDK;GEFDSLLQWPFR;ITLLENNDQR;REAVDGHTVSIFSQSFYTSRCGYR 4 10.4 0.96505 -1.1507 0 0 0 0 8.27015 0 0 0 0 8.63517 12.5634 0 O00468 AGRIN_HUMAN Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) clustering of voltage-gated sodium channels [GO:0045162]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; neuromuscular junction development [GO:0007528]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; synapse organization [GO:0050808] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; laminin binding [GO:0043236]; sialic acid binding [GO:0033691]; structural constituent of cytoskeleton [GO:0005200] ASCYNSALGCCSDGK;EAAYVCLCPGGFSGPHCEK;EPVTLGAWTR;GPCDRCGQCR;SELFGETAR;SGQCQGR;TYDSDCWRQQAECR;VRVWRYLK 8 4.4 0.97197 -2.7204 0 0 11.1916 0 7.55727 0 3.38805 0 2.62954 11.5848 3.06145 6.54703 O00469 PLOD2_HUMAN "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)" PLOD2 Homo sapiens (Human) collagen fibril organization [GO:0030199]; hydroxylysine biosynthetic process [GO:0046947]; peptidyl-lysine hydroxylation [GO:0017185]; protein modification process [GO:0036211]; response to hypoxia [GO:0001666] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum membrane [GO:0030867] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475] EFIAPVTLK;EMTLQREK;GGDGINSIGGGQK;ILIEQNRK;IVGPEENLSQAEAR;TLRSEMNER;VLGQGEEWR 7 9.2 0.97277 -2.9589 0 0 0 0 9.28306 0 11.2306 0 0 10.591 0 0 O00471 EXOC5_HUMAN Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) EXOC5 SEC10 SEC10L1 Homo sapiens (Human) epithelial cell apoptotic process [GO:1904019]; establishment of planar polarity [GO:0001736]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; non-motile cilium assembly [GO:1905515]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496] small GTPase binding [GO:0031267] LDTGIDR;LEQQCQK;LSECLQK;VEKLEQQCQKEAK 4 3.8 0.96492 -1.2524 0 0 0 10.3863 0 0 0 0 0 0 0 0 O00472 ELL2_HUMAN RNA polymerase II elongation factor ELL2 ELL2 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription elongation by RNA polymerase II [GO:0006368] nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] cis-regulatory region sequence-specific DNA binding [GO:0000987] DLSYTLK;LLDSEFIDPLMNK;QSSPNYHEEK;VIHLLALKAYKKPELLAR;VIKPGGPYVGKRVQIR;YIAIVSYEQRQNYK 6 12.2 0.97476 -1.3894 0 0 0 8.93446 4.98627 0 9.62057 0 0 6.00209 3.52519 0 O00478 BT3A3_HUMAN Butyrophilin subfamily 3 member A3 BTN3A3 BTF3 Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] KEWHIGVCSKNVER;YLCYFQDGDFYEKALVELK;YRALTEPRTNLK 3 7.7 0.97327 -2.4804 0 0 5.82617 0 0 0 0 0 0 0 10.9674 0 O00481 BT3A1_HUMAN Butyrophilin subfamily 3 member A1 (CD antigen CD277) BTN3A1 BTF5 Homo sapiens (Human) activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; positive regulation of cytokine production [GO:0001819]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] TLTEPRTNLKLPKPPK;YLCYFQDGDFYEKALVELK 2 6.8 0.96584 -1.1452 0 0 0 0 0 0 12.2384 0 0 0 0 0 O00482 NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) NR5A2 B1F CPF FTF Homo sapiens (Human) acinar cell differentiation [GO:0090425]; bile acid metabolic process [GO:0008206]; calcineurin-mediated signaling [GO:0097720]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; embryo development ending in birth or egg hatching [GO:0009792]; homeostatic process [GO:0042592]; hormone-mediated signaling pathway [GO:0009755]; pancreas morphogenesis [GO:0061113]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue development [GO:0009888] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" TVQNNKR 1 1.3 0.91678 -0.41751 0 0 0 0 0 0 9.37491 0 0 0 0 0 O00483 NDUA4_HUMAN Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit) NDUFA4 Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877] FYSVNVDYSK 1 12.3 0.93352 -0.50001 8.85141 0 0 0 0 0 0 0 0 0 0 0 O00487 PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1) PSMD14 POH1 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; regulation of proteasomal protein catabolic process [GO:0061136]; response to ethanol [GO:0045471]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" endopeptidase activator activity [GO:0061133]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; proteasome binding [GO:0070628] AGVPMEVMGLMLGEFVDDYTVR;AVAVVVDPIQSVK 2 11.3 0 2.0087 0 0 0 0 3.11864 0 0 0 0 8.60188 0 6.56707 O00488 ZN593_HUMAN Zinc finger protein 593 (Zinc finger protein T86) ZNF593 ZT86 Homo sapiens (Human) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ribosome biogenesis [GO:0042254] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; preribosome binding [GO:1990275]; zinc ion binding [GO:0008270] AAGMGSYVPPR 1 8.2 0.8972 -0.2341 0 0 0 0 9.07823 0 0 0 0 0 0 0 O00499 BIN1_HUMAN Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) BIN1 AMPHL Homo sapiens (Human) cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; lipid tube assembly [GO:0060988]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ventricular cardiac muscle cell action potential [GO:1903946]; nucleus localization [GO:0051647]; nucleus organization [GO:0006997]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of endocytosis [GO:0045807]; regulation of cell cycle process [GO:0010564]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of neuron differentiation [GO:0045664]; response to lipopolysaccharide [GO:0032496]; synaptic vesicle endocytosis [GO:0048488]; T-tubule organization [GO:0033292] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; cerebellar mossy fiber [GO:0044300]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lipid tube [GO:0060987]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; RNA polymerase II transcription repressor complex [GO:0090571]; synaptic vesicle [GO:0008021]; T-tubule [GO:0030315]; varicosity [GO:0043196]; vesicle [GO:0031982]; Z disc [GO:0030018] actin filament binding [GO:0051015]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; clathrin binding [GO:0030276]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]; RNA polymerase binding [GO:0070063]; signaling adaptor activity [GO:0035591]; tau protein binding [GO:0048156] DEQFEQCVQNFNK;HHYESLQTAKKK 2 4.2 0.76549 0.06702 6.86716 7.17053 0 0 0 0 0 0 0 0 0 0 O00505 IMA4_HUMAN Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) KPNA3 QIP2 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; protein-containing complex assembly [GO:0065003]; symbiont entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] cytosol [GO:0005829]; host cell [GO:0043657]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] GDFGTQK;VQTAALR 2 2.7 0.95522 -0.81784 0 0 0 0 0 0 0 0 0 8.80967 9.56287 0 O00506 STK25_HUMAN Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) STK25 SOK1 YSK1 Homo sapiens (Human) axonogenesis [GO:0007409]; cellular response to oxidative stress [GO:0034599]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GLDYLHSERK;LDRIGKGSFGEVYK;VQRFSHNRNHLTSTR 3 9.2 0.95948 -1.0457 0 0 10.3983 0 9.55789 0 0 10.8388 0 0 0 8.49177 O00507 USP9Y_HUMAN "Ubiquitin carboxyl-terminal hydrolase 9Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y)" USP9Y DFFRY Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; metal ion binding [GO:0046872] EKAWQTFIIDLLLHCPSK;GFWKQFRLWGEPVNLR;GGANLIK;NLASRISGQDETIKNLEIFR;RKWTWAVEWLGDELER;YISELTIARPHQIIMSPAIERSVRK 6 4 0.76312 0.068558 0 0 3.48993 0 0 0 0 0 7.8936 4.25323 0 6.27014 O00515 LAD1_HUMAN Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) LAD1 LAD Homo sapiens (Human) actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; extracellular exosome [GO:0070062] cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] TLEDEEEQER 1 1.9 0.80434 0.013246 0 0 0 0 4.27605 4.71205 0 0 0 0 0 0 O00519 FAAH1_HUMAN Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) FAAH FAAH1 Homo sapiens (Human) "arachidonate metabolic process [GO:0019369]; fatty acid catabolic process [GO:0009062]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]; regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0150036]" cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; organelle membrane [GO:0031090]; postsynapse [GO:0098794]; presynapse [GO:0098793] amidase activity [GO:0004040]; fatty acid amide hydrolase activity [GO:0017064]; identical protein binding [GO:0042802]; monoacylglycerol lipase activity [GO:0047372]; phospholipid binding [GO:0005543] ALLCEDMFR 1 1.6 0.90938 -0.31691 0 0 0 0 0 0 0 0 0 0 0 9.10546 O00522 KRIT1_HUMAN Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) KRIT1 CCM1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell redox homeostasis [GO:0045454]; endothelium development [GO:0003158]; integrin activation [GO:0033622]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; regulation of angiogenesis [GO:0045765]; regulation of establishment of cell polarity [GO:2000114]; small GTPase-mediated signal transduction [GO:0007264] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" APHWTNR;FPLDGEK;LNGQLMPTER 3 3.3 0.96751 -1.3221 6.71768 0 13.5114 0 0 9.85865 0 0 0 0 7.68503 0 O00533 NCHL1_HUMAN Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] CHL1 CALL Homo sapiens (Human) adult locomotory behavior [GO:0008344]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cognition [GO:0050890]; exploration behavior [GO:0035640]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; signal transduction [GO:0007165] apical part of cell [GO:0045177]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] protease binding [GO:0002020] DGNPFYFTDHRIIPSNNSGTFR;EPLLLGRGLIVYLMFLLLKFSK;IGGDLPK;IIPSNNSGTFR;VEEVKPLEGRRYHIYENGTLQINR 5 6.2 0.9339 -0.51072 0 0 0 8.79256 11.0799 0 0 0 11.7744 6.80851 0 11.9517 O00541 PESC_HUMAN Pescadillo homolog PES1 Homo sapiens (Human) "cell population proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]" "chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] GSATNYITRNK;ITHQIVDRPGQQTSVIGR;LAALEEQR;LAIMMMK;LAQEEESEAK;LDHIIKERYPTFIDALR;LFEGLKFFLNREVPR;QRLAQEEESEAK 8 15 0.97413 -2.4568 0 0 10.1272 9.70293 0 6.49432 0 10.6154 10.0681 0 11.3018 9.48965 O00548 DLL1_HUMAN Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1) DLL1 UNQ146/PRO172 Homo sapiens (Human) astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-dependent endocytosis [GO:0072583]; compartment pattern specification [GO:0007386]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; energy homeostasis [GO:0097009]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; myeloid cell differentiation [GO:0030099]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of hemocyte differentiation [GO:0045611]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; nephron development [GO:0072006]; neuroepithelial cell differentiation [GO:0060563]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; proximal/distal pattern formation [GO:0009954]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]; scaffold protein binding [GO:0097110]; Tat protein binding [GO:0030957] HCDDNVDDCASSPCANGGTCR;KADFHGDHSADK;NTNKKADFHGDHSADK;TDLKYSYRFVCDEHYYGEGCSVFCRPR 4 8.9 0.12224 0.35963 0 0 0 0 0 6.59837 0 0 0 7.01892 5.93734 0 O00555 CAC1A_HUMAN "Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)" CACNA1A CACH4 CACN3 CACNL1A4 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to amyloid-beta [GO:1904645] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] amyloid-beta binding [GO:0001540]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; syntaxin binding [GO:0019905]; voltage-gated calcium channel activity [GO:0005245] AATSGPR;EEEEDDR;ESPSWVTQR;GKYLLYEKNEVK;GLHEPYSESDDDWC;GNNLSTISDTSPMK;HASSGATGRSPR;HASSGATGRSPRTPR;LLRIFKVTK;STDLTVGKIYAAMMIMEYYRQSK;TMALYNPIPVRQNCLTVNR;VLRPLKLVSGIPSLQVVLK;VLRPLKTIKR;YAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDK 14 7.8 0.89556 -0.22941 0 0 0 0 0 0 0 10.923 0 0 0 0 O00555 CAC1A_HUMAN "Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)" CACNA1A CACH4 CACN3 CACNL1A4 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to amyloid-beta [GO:1904645] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] amyloid-beta binding [GO:0001540]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; syntaxin binding [GO:0019905]; voltage-gated calcium channel activity [GO:0005245] AATSGPR;EEEEDDR;ESPSWVTQR;GKYLLYEKNEVK;GLHEPYSESDDDWC;HASSGATGRSPR;HASSGATGRSPRTPR;LLRIFKVTK;LPAENQTISDTSPMKR;STDLTVGKIYAAMMIMEYYRQSK;TMALYNPIPVRQNCLTVNR;VLRPLKLVSGIPSLQVVLK;VLRPLKTIKR;YAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDK 14 7.9 0.97648 -4.9852 0 5.7451 7.1207 0 10.1072 6.82566 7.31587 11.4778 8.58052 0 7.93434 0 O00560 SDCB1_HUMAN Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) SDCBP MDA9 SYCL Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of receptor internalization [GO:0002091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynapse assembly [GO:0099054]; protein targeting to membrane [GO:0006612]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346]; substrate-dependent cell migration, cell extension [GO:0006930]" adherens junction [GO:0005912]; azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "cell adhesion molecule binding [GO:0050839]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; frizzled binding [GO:0005109]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; ionotropic glutamate receptor binding [GO:0035255]; neurexin family protein binding [GO:0042043]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; syndecan binding [GO:0045545]" MAPSIMK 1 2.3 0.91515 -0.39325 10.7755 0 0 0 0 0 0 0 0 0 0 0 O00562 PITM1_HUMAN "Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)" PITPNM1 DRES9 NIR2 PITPNM Homo sapiens (Human) brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031] cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496] calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971] ALEEETARMLAQRMAK;DPLADGVEGLGR 2 2.3 0.84537 -0.058679 0 0 0 0 0 0 0 9.11577 0 0 10.1016 0 O00567 NOP56_HUMAN Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] box C/D methylation guide snoRNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515] LLLETHLPSK;YPASTVQILGAEK 2 3.9 0.95232 -0.72152 0 0 0 0 0 0 0 0 0 9.71249 9.5445 0 O00570 SOX1_HUMAN Transcription factor SOX-1 SOX1 Homo sapiens (Human) brain development [GO:0007420]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; forebrain neuron development [GO:0021884]; interneuron migration [GO:1904936]; lens morphogenesis in camera-type eye [GO:0002089]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of oligodendrocyte differentiation [GO:0048713]; ventral spinal cord interneuron specification [GO:0021521] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQR 1 9 0.87628 -0.1335 0 0 0 0 0 0 0 0 0 0 8.82804 9.77528 O00571 DDX3X_HUMAN "ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)" DDX3X DBX DDX3 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to osmotic stress [GO:0071470]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; cytosolic ribosome assembly [GO:0042256]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; gamete generation [GO:0007276]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid homeostasis [GO:0055088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; positive regulation of translational initiation [GO:0045948]; positive regulation of type I interferon production [GO:0032481]; positive regulation of viral genome replication [GO:0045070]; protein localization to cytoplasmic stress granule [GO:1903608]; response to virus [GO:0009615]; RNA secondary structure unwinding [GO:0010501]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413]; Wnt signaling pathway [GO:0016055] cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; cadherin binding [GO:0045296]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; CTPase activity [GO:0043273]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; eukaryotic initiation factor 4E binding [GO:0008190]; gamma-tubulin binding [GO:0043015]; GTPase activity [GO:0003924]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; protein serine/threonine kinase activator activity [GO:0043539]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; signaling adaptor activity [GO:0035591]; transcription factor binding [GO:0008134]; translation initiation factor binding [GO:0031369] DLMACAQTGSGK;EEALHQFRSGK;IGLDFCK;IVEQDTMPPK;MLDMGFEPQIR;QSSGASSSSFSSSR;SDYDGIGSR;SPILVATAVAAR;VGNLGLATSFFNER;VGSTSENITQK;YLVLDEADR 11 18.1 0 6.0665 0 0 3.91514 0 9.37473 10.2935 11.187 11.6439 11.2232 12.2742 12.0101 0 O00584 RNT2_HUMAN Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6) RNASET2 RNASE6PL Homo sapiens (Human) innate immune response [GO:0045087]; RNA catabolic process [GO:0006401] azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; mitochondrial intermembrane space [GO:0005758] ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540] IQCLPPSQDEEVQTIGQIELCLTK 1 9.4 0.71063 0.15634 0 0 0 0 6.06141 0 0 0 0 0 0 0 O00585 CCL21_HUMAN C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21) CCL21 SCYA21 UNQ784/PRO1600 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell chemotaxis [GO:0060326]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine-mediated signaling pathway [GO:0070098]; dendritic cell chemotaxis [GO:0002407]; dendritic cell dendrite assembly [GO:0097026]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; mesangial cell-matrix adhesion [GO:0035759]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell dendrite assembly [GO:2000548]; negative regulation of leukocyte tethering or rolling [GO:1903237]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of chemotaxis [GO:0050921]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myeloid dendritic cell chemotaxis [GO:2000529]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; release of sequestered calcium ion into cytosol [GO:0051209]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR7 chemokine receptor binding [GO:0031732]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379] GASKTGK 1 5.2 0.68528 0.16272 0 0 10.1187 0 0 0 0 0 0 0 0 0 O00590 ACKR2_HUMAN Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6) ACKR2 CCBP2 CCR10 CMKBR9 D6 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of cytosolic calcium ion concentration [GO:0007204] actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044] IGCVLVR;QSENYPNK 2 3.9 0.95147 -0.70386 0 0 0 0 0 0 0 0 0 8.29412 7.29875 0 O00591 GBRP_HUMAN Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) (GABAAR subunit pi) GABRP Homo sapiens (Human) chloride transmembrane transport [GO:1902476] apical plasma membrane [GO:0016324]; chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594] SFTLDAR;TCIGVTTVLSMTTLMIGSR;TSLPNTNCFIK 3 8.4 0.94083 -0.58576 0 0 0 0 0 6.66789 0 0 8.92136 0 0 11.1243 O00592 PODXL_HUMAN Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) PODXL PCLP PCLP1 Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; epithelial tube formation [GO:0072175]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; podocyte development [GO:0072015]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534] apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; slit diaphragm [GO:0036057] EITIHTKLPAKDVYER;LSQRKDQQR 2 4.5 0.96535 -1.1581 0 11.9586 0 0 0 9.90239 0 0 0 0 0 0 O00602 FCN1_HUMAN Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; serine-type endopeptidase complex [GO:1905370] antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102] DQDNDVSSSNCAEK;GEKGMRGEK 2 7.1 0.96209 -1.0789 0 0 0 0 0 0 0 0 0 4.96394 0 0 O00624 NPT3_HUMAN Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2) SLC17A2 NPT3 Homo sapiens (Human) monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] LDKQNFK 1 1.6 0.90228 -0.26352 0 0 9.64144 0 0 0 0 0 0 0 0 0 O00625 PIR_HUMAN "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" PIR Homo sapiens (Human) digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]" SIGRPELK 1 2.8 0.91442 -0.39033 0 0 0 0 0 0 0 0 10.9817 0 0 0 O00628 PEX7_HUMAN Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) PEX7 PTS2R Homo sapiens (Human) endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein targeting to peroxisome [GO:0006625] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] enzyme binding [GO:0019899]; peroxisome matrix targeting signal-2 binding [GO:0005053]; protein homodimerization activity [GO:0042803] NVRQPVFELLGHTYAIRR 1 5.6 0.44681 0.19265 1.40103 0 0 0 0 0 0 0 0 0 0 10.9875 O00634 NET3_HUMAN Netrin-3 (Netrin-2-like protein) NTN3 NTN2L Homo sapiens (Human) axon guidance [GO:0007411]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]" DGVTGLTCNR;TCNQTTGQCPCKDGVTGLTCNRCAPGFQQSR 2 5.3 0.91018 -0.29808 0 0 8.54817 0 0 0 0 0 0 0 0 5.57984 O00635 TRI38_HUMAN E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) TRIM38 RNF15 RORET Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of defense response to virus [GO:0050687]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; regulation of interferon-beta production [GO:0032648]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ASTTSTK;CERAPQHK;NLQCFLHEEEK;VQIQRQK 4 7.1 0.97455 -3.1226 0 0 0 8.90881 10.4622 0 0 0 0 0 0 0 O00743 PPP6_HUMAN "Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]" PPP6C PPP6 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] APLDLDKYVEIAR;LICRAHQLVHEGYK 2 8.9 0.97643 -2.2735 0 0 11.931 0 0 0 0 0 0 0 0 0 O00744 WN10B_HUMAN Protein Wnt-10b (Protein Wnt-12) WNT10B WNT12 Homo sapiens (Human) bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; fungiform papilla development [GO:0061196]; G2/M transition of mitotic cell cycle [GO:0000086]; hematopoietic stem cell proliferation [GO:0071425]; lipid metabolic process [GO:0006629]; myoblast development [GO:0048627]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of timing of anagen [GO:0051885]; protein stabilization [GO:0050821]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of skeletal muscle tissue development [GO:0048641]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] CHCRFHWCCYVLCDECKVTEWVNVCK;FHWCCYVLCDECK;LSGELVYFEK;VTEWVNVCK 4 9.3 0.95398 -0.90538 0 0 5.21319 0 7.94638 11.3732 0 0 0 9.49534 0 0 O00746 NDKM_HUMAN "Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)" NME4 NM23D Homo sapiens (Human) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; lipid transport [GO:0006869]; nucleoside metabolic process [GO:0009116]; UTP biosynthetic process [GO:0006228] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; cardiolipin binding [GO:1901612]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] GLRCGPR 1 3.7 0.9688 -1.3317 0 0 0 8.46655 0 0 0 0 0 0 0 0 O00748 EST2_HUMAN Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) CES2 ICE Homo sapiens (Human) catabolic process [GO:0009056]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231] carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374] APVYFYEFQHQPSWLK 1 2.9 0.77925 0.035313 0 0 0 0 6.99944 0 8.29508 0 0 0 0 0 O00750 P3C2B_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B Homo sapiens (Human) autophagosome organization [GO:1905037]; cellular response to starvation [GO:0009267]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091] KGSPSSSK;LSISYKNNK;SSGRISDVFLCRHEK;TGLEEVKQFFALNGSCR;VGGEVKLSISYKNNK;VTHYFFWLLK;YEFGSLREEDQR;YEFGSLREEDQRK 8 4.8 0.97318 -2.8506 0 0 12.4614 12.1788 0 12.9269 0 8.42903 0 0 9.21866 14.2487 O00754 MA2B1_HUMAN Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] MAN2B1 LAMAN MANB Homo sapiens (Human) learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]; protein deglycosylation [GO:0006517]; protein modification process [GO:0036211] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] DLFSTFTITR;WWHQQTNATQEVVRDLVR 2 2.8 0.95586 -0.94204 0 0 0 0 0 0 11.4817 0 0 7.29407 0 0 O00755 WNT7A_HUMAN Protein Wnt-7a WNT7A Homo sapiens (Human) "angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; excitatory synapse assembly [GO:1904861]; lens fiber cell development [GO:0070307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; oviduct development [GO:0060066]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; regulation of axon diameter [GO:0031133]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; sex differentiation [GO:0007548]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synaptic vesicle recycling [GO:0036465]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] KILEENMKLECK;TVFGKELK 2 5.7 0.96725 -1.3098 0 0 0 0 0 0 0 0 0 0 6.92896 0 O00757 F16P2_HUMAN "Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)" FBP2 Homo sapiens (Human) "fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]" anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018] "fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" NIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEK 1 12.1 0.88203 -0.15922 0 0 0 0 0 0 0 11.1051 0 0 0 0 O00763 ACACB_HUMAN Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) ACACB ACC2 ACCB Homo sapiens (Human) acetyl-CoA metabolic process [GO:0006084]; D-glucose import [GO:0046323]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; intracellular aspartate homeostasis [GO:0090459]; intracellular glutamate homeostasis [GO:0090461]; lactic acid secretion [GO:0046722]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid beta-oxidation [GO:0031999]; pentose-phosphate shunt [GO:0006098]; positive regulation of heart growth [GO:0060421]; positive regulation of lipid storage [GO:0010884]; protein homotetramerization [GO:0051289]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; regulation of glucose metabolic process [GO:0010906]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; tricarboxylic acid metabolic process [GO:0072350] cytosol [GO:0005829]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] EKLPLMIFANWR;GFSGGMK;GVISDILEWK;LLLEDQVK;LTQYTVEDGGHVEAGSSYAEMEVMK;SPAKCKICFPDR;TCVFEKENDPTVLR 7 3.9 0.97625 -2.254 13.3859 13.2884 0 7.09075 5.24963 0 12.4828 0 12.8126 0 8.66473 9.73117 O00764 PDXK_HUMAN Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK C21orf124 C21orf97 PKH PNK PRED79 Homo sapiens (Human) pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; pyridoxamine metabolic process [GO:0042818] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580] ATP binding [GO:0005524]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; sodium ion binding [GO:0031402]; zinc ion binding [GO:0008270] RNPAGSVVMERIR 1 4.2 0.86631 -0.091798 0 0 0 0 4.19952 0 0 0 0 0 0 0 O14490 DLGP1_HUMAN Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) DLGAP1 DAP1 GKAP Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877] APPPVPK;EVYQKASVNMDQAMVK;FRSRNESYMR;ISNEHSPK;SVCHRDGHWFLK;TAVGSAQLLMAQK 6 6.8 0.97341 -2.6347 0 9.57065 7.49145 0 0 0 0 0 0 0 5.72686 8.68328 O14492 SH2B2_HUMAN SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) SH2B2 APS Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; brown fat cell differentiation [GO:0050873]; cytokine-mediated signaling pathway [GO:0019221]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; regulation of metabolic process [GO:0019222]; regulation of Ras protein signal transduction [GO:0046578] actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725] identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] TAEPRDK 1 1.1 0.90305 -0.26622 0 0 0 0 0 0 0 0 0 0 0 8.13427 O14494 PLPP1_HUMAN Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) PLPP1 LPP1 PPAP2A Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; ceramide metabolic process [GO:0006672]; negative regulation of cell population proliferation [GO:0008285]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; regulation of lipid metabolic process [GO:0019216]; signal transduction [GO:0007165]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] HTPFQRGVFCNDESIK;NNYIATIYK 2 8.8 0.92988 -0.48054 0 0 0 0 0 0 0 0 11.6685 0 0 0 O14495 PLPP3_HUMAN Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) PLPP3 LPP3 PPAP2B Homo sapiens (Human) "Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; ceramide metabolic process [GO:0006672]; gastrulation with mouth forming second [GO:0001702]; homotypic cell-cell adhesion [GO:0034109]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; signal transduction [GO:0007165]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670]; wound healing [GO:0042060]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ceramide-1-phosphate phosphatase activity [GO:0106235]; integrin binding [GO:0005178]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] AIVPESK 1 2.3 0.90996 -0.31006 0 0 0 0 0 0 0 0 0 0 0 9.74234 O14497 ARI1A_HUMAN "AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)" ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; transcription coactivator activity [GO:0003713] DPYGSMR;LYSTMVRFLSDR 2 0.8 0.91715 -0.43016 7.95128 0 0 0 0 0 0 9.25288 0 0 0 0 O14503 BHE40_HUMAN Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) BHLHE40 BHLHB2 DEC1 SHARP2 STRA13 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; MRF binding [GO:0043426]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" SEDSKETYKLPHR 1 3.2 0.8653 -0.086862 12.2011 0 0 0 0 0 0 0 0 0 0 0 O14508 SOCS2_HUMAN Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2) SOCS2 CIS2 SSI2 STATI2 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; response to estradiol [GO:0032355] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829] cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; JAK pathway signal transduction adaptor activity [GO:0008269]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LDSIICVK;LKQFDSVVHLIDYYVQMCKDK 2 14.6 0.91629 -0.41675 0 0 0 0 0 0 9.981 0 0 0 0 0 O14511 NRG2_HUMAN "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]" NRG2 NTAK Homo sapiens (Human) animal organ development [GO:0048513]; ERBB4 signaling pathway [GO:0038130]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] GAHDALR 1 0.8 0.91038 -0.31982 0 0 0 0 0 0 0 7.70591 0 0 0 0 O14512 SOCS7_HUMAN "Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)" SOCS7 NAP4 SOCS6 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; layer formation in cerebral cortex [GO:0021819]; negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of neuron migration [GO:2001222] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] phosphorylation-dependent protein binding [GO:0140031]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FEDRCQSVVEFIK;GGGGGGR;GTFSLWCHPK 3 5.2 0.95225 -0.7088 7.63445 6.8226 0 0 0 0 0 10.6991 0 0 0 0 O14513 NCKP5_HUMAN Nck-associated protein 5 (NAP-5) (Peripheral clock protein) NCKAP5 ERIH NAP5 Homo sapiens (Human) microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019] microtubule plus-end [GO:0035371] AAARDYTFFK;DIGLQTPR;EALEDLHMVVDEDSRSESSSTDEGK;GVPKTSPRQTLGTPQR;KSRLPALSSR;LPALSSR;RKVLLEPPSVITK;SDPHIPK;VLGFGNR 9 5 0.97625 -5.0211 6.52532 0 11.5484 0 12.6789 9.92563 0 0 0 9.17752 7.3336 0 O14514 AGRB1_HUMAN Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] ADGRB1 BAI1 Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic cell clearance [GO:0043277]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; engulfment of apoptotic cell [GO:0043652]; G protein-coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; peripheral nervous system development [GO:0007422]; phagocytosis, recognition [GO:0006910]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synapse assembly [GO:0051965]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]" cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; PDZ domain binding [GO:0030165]; phosphatidylserine binding [GO:0001786] DVDLACR;ELFRLVEDFVDVIGFRMK;GGHGATGGWK;MRGQAAAPGPVWILAPLLLLLLLLGRR;NMTEIFR;RGQAAAPGPVWILAPLLLLLLLLGRR;STDARRR;SVFSTGLTEADEASVFVVGTVLYR 8 6.3 0.97915 -2.0469 4.86101 9.71691 0 5.55756 0 4.56108 10.7768 12.4701 11.2636 0 7.92434 8.72069 O14519 CDKA1_HUMAN Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) CDK2AP1 CDKAP1 DOC1 Homo sapiens (Human) DNA-templated DNA replication [GO:0006261]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; perinuclear region of cytoplasm [GO:0048471] DNA polymerase binding [GO:0070182] EIRPTYAGSK 1 8.7 0.78454 0.02472 0 0 0 0 0 0 0 0 0 8.56175 0 0 O14520 AQP7_HUMAN Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (Aquaporin adipose) (AQPap) (Aquaporin-7-like) AQP7 AQP7L AQP9 Homo sapiens (Human) glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] ISGAHMNAAVTFANCALGRVPWR 1 6.7 0.83436 -0.029624 0 0 0 0 0 0 0 0 0 0 0 9.72091 O14522 PTPRT_HUMAN Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] "alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" GQGYGFK;IVQHLQYIGWPAYR 2 1.5 0.95118 -0.69709 9.5831 0 0 0 0 0 0 0 8.10993 0 0 0 O14523 C2C2L_HUMAN Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) C2CD2L KIAA0285 TMEM24 DLNB23 Homo sapiens (Human) positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886] insulin binding [GO:0043559]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] LDSPSRSPSK 1 1.4 0.96522 -1.1599 0 0 0 0 10.3476 10.7525 0 0 0 0 0 0 O14524 NEMP1_HUMAN Nuclear envelope integral membrane protein 1 NEMP1 KIAA0286 TMEM194 TMEM194A Homo sapiens (Human) erythrocyte enucleation [GO:0043131]; erythrocyte maturation [GO:0043249]; nuclear membrane organization [GO:0071763] nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] WHDIWTRIQIR 1 2.5 0.98033 -1.5724 0 10.9388 0 0 0 0 0 9.55177 0 0 0 0 O14525 ASTN1_HUMAN Astrotactin-1 ASTN1 ASTN KIAA0289 Homo sapiens (Human) locomotory behavior [GO:0007626]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764] clathrin-coated vesicle [GO:0030136]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; perikaryon [GO:0043204] GNSPSDESEERER;HMAAGVR 2 1.5 0.95905 -1.0337 0 0 0 0 0 0 0 0 0 0 0 10.9356 O14526 FCHO1_HUMAN F-BAR domain only protein 1 FCHO1 KIAA0290 Homo sapiens (Human) clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843] AP-2 adaptor complex binding [GO:0035612] QNIENVSVEMLLR 1 1.5 0.93747 -0.54136 0 0 0 0 9.38735 0 0 0 0 0 0 0 O14529 CUX2_HUMAN Homeobox protein cut-like 2 (Homeobox protein cux-2) CUX2 CUTL2 KIAA0293 Homo sapiens (Human) cognition [GO:0050890]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of synapse assembly [GO:0051965]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LAKNGICQRIFGEK;RDLHTSWK 2 1.5 0.84057 -0.043952 0 0 0 10.8003 0 0 0 0 0 0 0 0 O14530 TXND9_HUMAN Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) TXNDC9 APACD Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634] cadherin binding [GO:0045296] KYDSDSDDD;LHIKVIPTLALLK;YDSDSDDD 3 9.7 0.93698 -0.55675 9.52368 0 0 0 0 0 0 4.9721 7.48872 0 0 0 O14544 SOCS6_HUMAN Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) SOCS6 CIS4 SOCS4 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008] cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772] signaling adaptor activity [GO:0035591] DSENGAFCYSR;IDLIQKLPLPNKMK;SLQYLCR 3 6 0.92175 -0.44688 0 5.25024 0 0 7.80491 0 0 0 0 0 0 0 O14556 G3PT_HUMAN "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)" GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; positive regulation of glycolytic process [GO:0045821] cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661] GAHQNIIPASTGAAK;LTGMAFR;LVLRACMEK;VPTPDVSVVDLTCR 4 11 0.97989 -1.8208 0 0 0 8.92653 0 8.08523 0 0 0 9.77078 0 0 O14559 RHG33_HUMAN Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) ARHGAP33 SNX26 TCGAP Homo sapiens (Human) protein transport [GO:0015031]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynapse assembly [GO:0150052]; response to toxic substance [GO:0009636]; small GTPase-mediated signal transduction [GO:0007264] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; fibrillar center [GO:0001650]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901] EILDGNR;GKPGKRLSAPR 2 7.3 0.97892 -1.9662 0 14.8282 0 0 0 8.58823 0 0 0 0 0 0 O14578 CTRO_HUMAN Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; neuron apoptotic process [GO:0051402]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956] cytosol [GO:0005829]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; transcription coactivator binding [GO:0001223] ADVPYILKMESHPHTTCWPGR;EPYLFVTHFNSLEVIEIQAR;EVSLEHEEQK;LHRRVSEVEAVLSQK;LKERMHHNIPHR;MHHNIPHRFNVGLNMRATK;MNSPGLQTK;QVVELAVKEHK;RSDLYESELRESR;VPLQYNELKLALEKEK 10 8.9 0.48028 0.19043 0 0 0 0 0 0 0 0 0 0 7.30515 0 O14578 CTRO_HUMAN Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; neuron apoptotic process [GO:0051402]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956] cytosol [GO:0005829]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; transcription coactivator binding [GO:0001223] ADVPYILKMESHPHTTCWPGR;ELQDSQDKCHKMEQEMTR;EPYLFVTHFNSLEVIEIQAR;EVSLEHEEQK;IDWNNIR;ILELEEK;LHRRVSEVEAVLSQK;LKERMHHNIPHR;LVEAEERR;MHHNIPHRFNVGLNMRATK;MNSPGLQTK;QVVELAVKEHK;RSDLYESELRESR;SDDDTSNFDEPEK 14 8.5 0.97803 -8.0109 0 0 0 9.63775 9.20741 10.2423 10.8041 11.241 0 10.7594 11.4161 12.2041 O14579 COPE_HUMAN Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) COPE Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein localization to axon [GO:0099612]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] EYQAKENDFDR;LDRLDLARK 2 6.5 0.98052 -1.6806 0 0 0 0 0 0 7.41903 0 0 0 0 0 O14595 CTDS2_HUMAN Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2) CTDSP2 NIF2 OS4 SCP2 Homo sapiens (Human) negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; protein dephosphorylation [GO:0006470] nucleoplasm [GO:0005654] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] CGVFRARLFR 1 3.7 0.96509 -1.2481 11.1774 0 0 0 0 0 0 0 0 0 0 0 O14602 IF1AY_HUMAN "Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)" EIF1AY Homo sapiens (Human) translational initiation [GO:0006413] cytoplasm [GO:0005737] translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] LEALCFDGVK 1 6.9 0.92207 -0.44531 0 0 0 0 0 0 0 12.6486 0 0 0 0 O14613 BORG1_HUMAN Cdc42 effector protein 2 (Binder of Rho GTPases 1) CDC42EP2 BORG1 CEP2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; opioid peptide activity [GO:0001515]; small GTPase binding [GO:0031267] STKVPIYLK 1 4.3 0.98106 -1.6064 0 0 0 0 0 6.76009 0 0 0 0 0 0 O14617 AP3D1_HUMAN AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) AP3D1 PRO0039 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endosome to melanosome transport [GO:0035646]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to membrane [GO:0072657]; protein targeting to vacuole [GO:0006623]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle coating [GO:0016183]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]; zinc ion import into lysosome [GO:0140916]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; postsynapse [GO:0098794]; presynaptic endosome [GO:0098830]; terminal bouton [GO:0043195] AVFHEEEQR;LEEERRHR;LLESGDLSMSSIK;MALKMVK;QDNIAVKANAVCK;SSSILKGMELSVLDSLNAR 6 6 0.97743 -2.1679 0 4.05494 0 0 0 8.0782 0 0 10.8887 12.4 10.5859 0 O14625 CXL11_HUMAN C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11) CXCL11 ITAC SCYB11 SCYB9B Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell chemotaxis [GO:0010818] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; heparin binding [GO:0008201] ENKGQRCLNPK 1 11.7 0.76529 0.062898 0 11.432 0 0 0 0 0 10.1635 0 0 0 0 O14626 GP171_HUMAN G-protein coupled receptor 171 (G-protein coupled receptor H963) GPR171 H963 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of feeding behavior [GO:0060259]; regulation of sensory perception of pain [GO:0051930] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] NWHLLTNFICVAIFLNFSAIILISNCLVIR;VTETFASPKETK 2 13.2 0.97945 -1.5446 0 0 0 0 0 10.8173 0 0 0 0 11.1546 0 O14638 ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) ENPP3 PDNP3 Homo sapiens (Human) ATP metabolic process [GO:0046034]; basophil activation involved in immune response [GO:0002276]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell proliferation [GO:0070667]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; pyrimidine nucleotide metabolic process [GO:0006220] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 8-oxo-(d)RTP hydrolase activity [GO:0106379]; ATP diphosphatase activity [GO:0047693]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; calcium ion binding [GO:0005509]; GTP diphosphatase activity [GO:0036219]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphodiesterase I activity [GO:0004528]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270] DRGDCCWDFEDTCVESTR;DVELLTGLDFYQDK;LEASLCSCSDDCLQR;YKIACIVLLALLVIMSLGLGLGLGLR 4 8.3 0.83235 -0.02868 0 0 0 0 9.85336 0 0 0 0 0 9.27298 0 O14639 ABLM1_HUMAN Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) ABLIM1 ABLIM KIAA0059 LIMAB1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872] LIVEDRRVSGTSFTAHR;VLEAGDK;VLTGEYISK 3 4.2 0.96163 -1.0676 0 9.91569 0 0 0 0 0 0 0 0 0 0 O14640 DVL1_HUMAN Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) DVL1 Homo sapiens (Human) "axon extension [GO:0048675]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; dendritic spine morphogenesis [GO:0060997]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube development [GO:0021915]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prepulse inhibition [GO:0060134]; presynapse assembly [GO:0099054]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle exocytosis [GO:2000300]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synapse organization [GO:0050808]; synaptic vesicle exocytosis [GO:0016079]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; Wnt signalosome [GO:1990909] beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] AMGNPCEFFVDIM;ELAAVPPELTGSR;SYFTVPR;VMQLPDSGLEIR 4 6.5 0.97654 -1.4883 9.97814 0 0 5.79709 0 0 0 9.45568 0 13.9015 0 0 O14641 DVL2_HUMAN Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) DVL2 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; convergent extension involved in neural plate elongation [GO:0022007]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" aggresome [GO:0016235]; apical part of cell [GO:0045177]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] IPVPAERITLGDFK;ITLGDFK 2 1.9 0.95283 -0.76601 0 0 0 8.56731 0 0 0 0 0 0 0 0 O14645 IDLC_HUMAN "Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28)" DNALI1 Homo sapiens (Human) sperm flagellum assembly [GO:0120316] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; dynein complex [GO:0030286]; filopodium [GO:0030175]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] dynein heavy chain binding [GO:0045504] ETGICPVR;GLLLLRVR;QVEEKKHNEEIQFLK;YDTPVLVSR 4 15.5 0.96467 -1.231 10.9635 10.562 0 0 0 3.77421 0 0 0 10.5035 0 0 O14646 CHD1_HUMAN Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; nucleosome organization [GO:0034728]; positive regulation by host of viral transcription [GO:0043923] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; single-stranded 3'-5' DNA helicase activity [GO:1990518] DQETKRWLK;LVISHEEELIPLHK;MEMSALQK;MLDILAEYLKYRQFPFQR;QFPFQRLDGSIKGELR;QIDSSEEDDDEEDYDNDK;SDEDDDK;SDSSPLPSEK;SSCDETESDYEPK;SSRDYRYHSDWQMDHR;VDGAEFWK 11 7.7 0.97228 -2.8343 0 12.1146 7.99949 0 0 0 5.64999 0 6.83592 0 9.08802 6.00466 O14647 CHD2_HUMAN Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2) CHD2 Homo sapiens (Human) DNA damage response [GO:0006974]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; muscle organ development [GO:0007517]; nucleosome organization [GO:0034728] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518] DLVEGFTDAEIRRFIK;HHQYEQHWYK;ISGVQVNVK;LILLDKLLTRLR;QDSSDEDDDDDEAPK;SPLDHRSPLER;TILENNSGR 7 4.5 0.97099 -1.3407 0 0 0 0 9.17867 8.4054 0 9.584 13.3689 0 0 0 O14649 KCNK3_HUMAN Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) KCNK3 TASK TASK1 Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to hypoxia [GO:0071456]; cellular response to zinc ion [GO:0071294]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of action potential firing rate [GO:0099605]; regulation of resting membrane potential [GO:0060075]; response to xenobiotic stimulus [GO:0009410] plasma membrane [GO:0005886]; synapse [GO:0045202] metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; open rectifier potassium channel activity [GO:0005252]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]; S100 protein binding [GO:0044548]; sodium channel activity [GO:0005272] EKLQYSIPMIIPR;VVLRLKPHK;YNLSQGGYEELERVVLR 3 8.9 0.95215 -0.73964 0 0 0 0 7.24802 0 8.74702 0 0 10.9363 0 0 O14654 IRS4_HUMAN Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) IRS4 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548] DNQFDSPKR;GATKECK 2 1.3 0.98144 -1.7721 0 0 0 8.11879 0 0 0 0 0 0 0 0 O14656 TOR1A_HUMAN Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A) TOR1A DQ2 DYT1 TA TORA Homo sapiens (Human) "cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; ERAD pathway [GO:0036503]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]" cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein folding chaperone [GO:0140662]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; cytoskeletal protein binding [GO:0008092]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082] VAEEMTFFPKEER 1 3.9 0.83533 -0.031552 0 6.58874 0 0 0 0 0 0 0 0 0 0 O14662 STX16_HUMAN Syntaxin-16 (Syn16) STX16 Homo sapiens (Human) "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] ATRRLTDAFLLLR;LTDAFLLLR;QKMKELASLHDK 3 7.7 0.96501 -1.2166 9.06402 0 0 11.1542 11.0345 0 0 0 0 0 0 11.6032 O14668 TMG1_HUMAN Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) PRRG1 PRGP1 TMG1 Homo sapiens (Human) blood coagulation [GO:0007596] extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] QGNIERECK 1 4.1 0.97534 -1.391 0 0 0 9.31327 9.10056 8.85019 0 0 0 0 0 0 O14672 ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) ADAM10 KUZ MADM Homo sapiens (Human) adherens junction organization [GO:0034332]; amyloid precursor protein catabolic process [GO:0042987]; cell-cell signaling [GO:0007267]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; extracellular matrix disassembly [GO:0022617]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612] adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197] endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102] DTSLFSDEFKVETSNK 1 2.1 0.8811 -0.17027 0 0 0 0 0 0 0 9.47529 0 0 0 0 O14678 ABCD4_HUMAN Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) ABCD4 PXMP1L Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760] ATP-binding cassette (ABC) transporter complex [GO:0043190]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324] ISQDVERFCR 1 1.7 0.92067 -0.44646 0 0 8.99421 0 0 0 0 0 0 0 0 0 O14681 EI24_HUMAN Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) EI24 PIG8 Homo sapiens (Human) apoptotic process [GO:0006915]; macroautophagy [GO:0016236]; negative regulation of cell growth [GO:0030308] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965] importin-alpha family protein binding [GO:0061676] LDARIQQK;TFLQDLAR 2 4.7 0.97919 -1.8816 0 0 13.1301 9.89376 0 0 11.7736 0 0 0 0 0 O14682 ENC1_HUMAN Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein) ENC1 KLHL37 NRPB PIG10 Homo sapiens (Human) negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of neuron projection development [GO:0010976]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; protein ubiquitination [GO:0016567] chromatin [GO:0000785]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779] AVLAACSR;LYELSWRMCLSNFQTIR 2 4.2 0.91743 -0.40862 0 0 0 0 0 0 0 0 0 0 0 11.2804 O14684 PTGES_HUMAN Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein) PTGES MGST1L1 MPGES1 PGES PIG12 Homo sapiens (Human) cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of prostaglandin secretion [GO:0032308]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693]; regulation of fever generation [GO:0031620]; regulation of inflammatory response [GO:0050727]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471] glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; prostaglandin-D synthase activity [GO:0004667]; prostaglandin-E synthase activity [GO:0050220] AFANPEDALR 1 6.6 0.81256 -0.011591 0 0 0 0 0 0 0 0 0 11.131 11.1625 0 O14686 KMT2D_HUMAN Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) KMT2D ALR MLL2 MLL4 Homo sapiens (Human) beta-catenin-TCF complex assembly [GO:1904837]; heterochromatin formation [GO:0031507]; methylation [GO:0032259]; oocyte growth [GO:0001555]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estrogen [GO:0043627] MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] ALCAKQRTAK;CCFCHEEGDGATDGPAR;EDAAARKPLTPKPKR;EKGLEGKSPDTGPDWLK;LAGLEQK;TEWKNNVYLAR;VLEEQIGVHR 7 1.6 0.97456 -3.6769 5.10245 12.0686 0 0 0 8.29985 0 9.10331 8.58549 0 0 4.98454 O14709 ZN197_HUMAN Zinc finger protein 197 (Zinc finger protein with KRAB and SCAN domains 9) (ZnF20) (pVHL-associated KRAB domain-containing protein) ZNF197 ZKSCAN9 ZNF166 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEEPYKCNKCQK;VLTSSRNLMVHQR;VSLCERDK;WLRPEAR 4 3.9 0.97306 -2.5246 0 0 0 0 0 0 0 0 0 0 0 7.90394 O14713 ITBP1_HUMAN Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) ITGB1BP1 ICAP1 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; biomineral tissue development [GO:0031214]; blood vessel diameter maintenance [GO:0097746]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; Notch signaling pathway [GO:0007219]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; receptor clustering [GO:0043113]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of GTPase activity [GO:0043087]; regulation of integrin-mediated signaling pathway [GO:2001044]; tube formation [GO:0035148] cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726] GDP-dissociation inhibitor activity [GO:0005092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901] HSSSSSQSSEISTKSK 1 8 0.91668 -0.42673 0 0 0 0 0 0 0 0 8.77982 0 0 0 O14717 TRDMT_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet) TRDMT1 DNMT2 Homo sapiens (Human) response to amphetamine [GO:0001975]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA methyltransferase activity [GO:0008175] AITLSSP 1 6.5 0.69442 0.16208 0 0 0 0 0 0 0 9.4588 0 0 0 0 O14727 APAF_HUMAN Apoptotic protease-activating factor 1 (APAF-1) APAF1 KIAA0413 Homo sapiens (Human) apoptotic process [GO:0006915]; cardiac muscle cell apoptotic process [GO:0010659]; cell differentiation [GO:0030154]; cellular response to transforming growth factor beta stimulus [GO:0071560]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to G1 DNA damage checkpoint signaling [GO:0072432]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584] apoptosome [GO:0043293]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] ADP binding [GO:0043531]; ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166] ADLPEQAHSIIK;KADLPEQAHSIIK;SVLAAEAVRDHSLLEGCFPGGVHWVSVGK;VCKNSAVMLKQEVDVVFQENEVMVLAVDHIR 4 5.8 0.81529 -0.0023049 0 10.2944 0 0 0 0 0 0 7.0917 0 8.11967 10.1313 O14730 RIOK3_HUMAN Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog) RIOK3 SUDD Homo sapiens (Human) cellular response to dsDNA [GO:1990786]; cellular response to dsRNA [GO:0071359]; cellular response to virus [GO:0098586]; chromosome segregation [GO:0007059]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; maturation of SSU-rRNA [GO:0030490]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728] "cytosol [GO:0005829]; preribosome, small subunit precursor [GO:0030688]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IIRMWAEK 1 1.5 0.91356 -0.33804 0 0 0 0 0 0 0 0 0 0 0 11.1038 O14733 MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of telomere maintenance [GO:0032206]; regulation of motor neuron apoptotic process [GO:2000671]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310] DVMAKTESPR;TGHVIAVK 2 4.3 0.98035 -1.6389 0 0 0 0 0 0 0 0 0 15.6312 0 0 O14734 ACOT8_HUMAN Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE) ACOT8 ACTEIII PTE1 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; dicarboxylic acid catabolic process [GO:0043649]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; negative regulation of CD4 production [GO:0045225]; peroxisome fission [GO:0016559] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] acetoacetyl-CoA hydrolase activity [GO:0047603]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0016289]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; fatty acyl-CoA hydrolase activity [GO:0047617]; hydroxymethylglutaryl-CoA hydrolase activity [GO:0047994]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]; succinyl-CoA hydrolase activity [GO:0004778] GLVHGRLWR;MEPKQMFWVR;TGSSFSVRSVK 3 9.4 0.98009 -1.7157 0 15.3896 15.4306 13.3066 0 0 0 0 0 0 8.39258 14.3657 O14737 PDCD5_HUMAN Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) PDCD5 TFAR19 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of chaperone-mediated protein folding [GO:1903645]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; heparin binding [GO:0008201] ADEELEALRR;AVENYLIQMAR;KVSQQTEK;NSILAQVLDQSAR;VSQQTEK;YGQLSEK 6 39.2 0.97543 -2.3511 12.246 0 0 0 0 0 0 9.86563 11.468 0 0 0 O14744 ANM5_HUMAN "Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]" PRMT5 HRMT1L5 IBP72 JBP1 SKB1 Homo sapiens (Human) "chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA-templated transcription termination [GO:0006353]; endothelial cell activation [GO:0042118]; Golgi ribbon formation [GO:0090161]; liver regeneration [GO:0097421]; negative regulation of cell differentiation [GO:0045596]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; peptidyl-arginine methylation [GO:0018216]; peptidyl-arginine N-methylation [GO:0035246]; positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:1904992]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of mitotic nuclear division [GO:0007088]; regulation of signal transduction by p53 class mediator [GO:1901796]; spliceosomal snRNP assembly [GO:0000387]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] E-box binding [GO:0070888]; histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3 methyltransferase activity [GO:0140938]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; transcription corepressor activity [GO:0003714] AAILPTSIFLTNK;AAMAVGGAGGSR;EFIQEPAK 3 5.2 0.0086022 1.0192 0 12.2204 0 0 0 3.17249 0 10.0794 0 0 10.6059 0 O14745 NHRF1_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) NHERF1 NHERF SLC9A3R1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; fibroblast migration [GO:0010761]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; intracellular phosphate ion homeostasis [GO:0030643]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of sodium ion transport [GO:0010766]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane protein complex [GO:0098797]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; channel activator activity [GO:0099103]; chloride channel regulator activity [GO:0017081]; dopamine receptor binding [GO:0050780]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800] EADKSHPEQR;EALAEAALESPRPALVR;LLVVDPETDEQLQK;LVEPGSPAEK;SADAAAGAPLPR 5 17.6 0 13.419 7.74799 10.2531 11.7541 10.214 9.25224 10.0987 0 0 0 0 12.1011 0 O14746 TERT_HUMAN Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) TERT EST2 TCS1 TRT Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; DNA biosynthetic process [GO:0071897]; DNA strand elongation [GO:0022616]; establishment of protein localization to telomere [GO:0070200]; mitochondrion organization [GO:0007005]; negative regulation of cellular senescence [GO:2000773]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of D-glucose import [GO:0046326]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hair cycle [GO:0042635]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transdifferentiation [GO:1903620]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of protein stability [GO:0031647]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; RNA-templated DNA biosynthetic process [GO:0006278]; RNA-templated transcription [GO:0001172]; siRNA processing [GO:0030422]; siRNA transcription [GO:0140745]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nuclear speck [GO:0016607]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; RNA-directed RNA polymerase complex [GO:0031379]; telomerase catalytic core complex [GO:0000333]; telomerase holoenzyme complex [GO:0005697]; TERT-RMRP complex [GO:1990572]" DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA-dependent RNA polymerase activity [GO:0003968]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; template-free RNA nucleotidyltransferase [GO:0098680]; transcription coactivator binding [GO:0001223]; tRNA binding [GO:0000049] AAPAFGG;ELVARVLQRLCER;GAAPEPERTPVGQGSWAHPGR;HAKLSLQELTWKMSVR;LTEVIASIIKPQNTYCVRR 5 9.4 0.96387 -1.1907 0 7.5815 0 6.62474 8.43941 0 10.2285 11.4993 0 8.75919 0 0 O14757 CHK1_HUMAN Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) CHEK1 CHK1 Homo sapiens (Human) "apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; cellular response to caffeine [GO:0071313]; cellular response to mechanical stimulus [GO:0071260]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G2/M transition of mitotic cell cycle [GO:0000086]; inner cell mass cell proliferation [GO:0001833]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of mitotic nuclear division [GO:0045839]; nucleus organization [GO:0006997]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle [GO:0045787]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of mitotic centrosome separation [GO:0046602]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]" centrosome [GO:0005813]; chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; replication fork [GO:0005657] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FFTKLDADK;ISDFGLATVFRYNNRER;KGAKRPR;TYLNPWK 4 8.4 0.95523 -0.81225 0 0 0 0 0 0 0 0 10.6192 8.17263 0 9.99195 O14764 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) (GABAAR subunit delta) GABRD Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] SAGQFPR 1 1.5 0.93602 -0.52005 0 0 0 0 0 0 0 0 0 8.92011 0 0 O14771 ZN213_HUMAN Zinc finger protein 213 (Putative transcription factor CR53) (Zinc finger protein with KRAB and SCAN domains 21) ZNF213 ZKSCAN21 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" WGHGGGR 1 2.3 0.8227 -0.017923 0 0 0 0 0 0 0 9.35823 0 0 0 0 O14772 FPGT_HUMAN Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase) FPGT GFPP Homo sapiens (Human) fucose metabolic process [GO:0006004]; GDP-L-fucose biosynthetic process [GO:0042350] cytoplasm [GO:0005737]; cytosol [GO:0005829] fucose-1-phosphate guanylyltransferase activity [GO:0047341]; GTP binding [GO:0005525] NTSNVIK;WNSFTILLIHSGGYSQR 2 4 0.92854 -0.47109 0 0 0 0 0 0 0 0 9.54044 0 0 0 O14775 GNB5_HUMAN Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) GNB5 Homo sapiens (Human) dark adaptation [GO:1990603]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; light adaption [GO:0036367]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] cell tip [GO:0051286]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; GTPase activator complex [GO:1902773]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] G-protein gamma-subunit binding [GO:0031682]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein-folding chaperone binding [GO:0051087]; signaling receptor complex adaptor activity [GO:0030159] IVSSSQDGKVIVWDSFTTNK 1 5.1 0.81183 -0.01308 0 0 5.59383 0 7.36833 0 0 0 0 0 0 0 O14776 TCRG1_HUMAN Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] DKVESDPR;FSSSDRK;KQVFDQYVK;SEQTKEIDRER;VESDPRYK 5 3.4 0.93583 -0.53291 0 12.124 7.81954 4.33006 2.71488 13.072 0 0 0 4.61247 0 10.6371 O14777 NDC80_HUMAN Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) NDC80 HEC HEC1 KNTC2 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centrosome duplication [GO:0051298]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/MI transition of meiotic cell cycle [GO:0008315]; kinetochore organization [GO:0051383]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle assembly involved in female meiosis I [GO:0007057] "centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]" cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; kinetochore adaptor activity [GO:0140483]; microtubule binding [GO:0008017] EYQLVVQTTTEER;GAENSKGYDFEIK;LEQEREK;LESLEAKNR;LTKDLEAEQQK;TSGHGSR 6 9.3 0.975 -4.0064 0 8.89781 9.29006 0 0 0 10.3026 0 10.9111 0 0 0 O14782 KIF3C_HUMAN Kinesin-like protein KIF3C KIF3C Homo sapiens (Human) microtubule-based movement [GO:0007018] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GVIPNAFEHIFTHISR;LDSFLERPSTSK;LEEEKAAIQDDR;SLVSEEKQK;SLVSEEKQKLLEEK 5 6.8 0.97826 -2.1282 6.60743 0 0 7.39934 0 10.3164 0 0 0 0 9.40122 6.36077 O14786 NRP1_HUMAN Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) NRP1 NRP VEGF165R Homo sapiens (Human) "angiogenesis [GO:0001525]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; artery morphogenesis [GO:0048844]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; basal dendrite development [GO:0150018]; branching involved in blood vessel morphogenesis [GO:0001569]; branchiomotor neuron axon guidance [GO:0021785]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; dorsal root ganglion morphogenesis [GO:1904835]; endothelial cell chemotaxis [GO:0035767]; endothelial tip cell fate specification [GO:0097102]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; integrin-mediated signaling pathway [GO:0007229]; motor neuron axon guidance [GO:0008045]; motor neuron migration [GO:0097475]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; neuropilin signaling pathway [GO:0038189]; otic placode development [GO:1905040]; outflow tract septum morphogenesis [GO:0003148]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynapse organization [GO:0099173]; protein localization to early endosome [GO:1902946]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vesicle-mediated transport [GO:0060627]; renal artery morphogenesis [GO:0061441]; response to wounding [GO:0009611]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate-dependent cell migration, cell extension [GO:0006930]; symbiont entry into host cell [GO:0046718]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]" axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neurofilament [GO:0005883]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; semaphorin receptor complex [GO:0002116]; sorting endosome [GO:0097443] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; GTPase activator activity [GO:0005096]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] FVSDYETHGAGFSIRYEIFKR;IKPATWETGISMRFEVYGCK;LEIWDGFPDVGPHIGRYCGQKTPGR;SPGFPEK;VLLHKSLK 5 8.8 0.9564 -0.85065 0 0 0 0 4.70038 8.94676 11.6017 12.1221 0 11.6229 11.2124 0 O14788 TNF11_HUMAN "Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]" TNFSF11 OPGL RANKL TRANCE Homo sapiens (Human) bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cellular response to leukemia inhibitory factor [GO:1990830]; cytokine-mediated signaling pathway [GO:0019221]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; JNK cascade [GO:0007254]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; monocyte chemotaxis [GO:0002548]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of corticotropin-releasing hormone secretion [GO:0051466]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast development [GO:2001206]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell activation [GO:0050870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; tooth eruption [GO:0044691]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813] VSLSSWYHDR 1 3.2 0.89647 -0.23758 0 0 0 0 0 0 0 0 7.4503 0 0 0 O14791 APOL1_HUMAN Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) APOL1 APOL Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; cholesterol metabolic process [GO:0008203]; cytolysis by host of symbiont cells [GO:0051838]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; membrane [GO:0016020]; very-low-density lipoprotein particle [GO:0034361] chloride channel activity [GO:0005254]; lipid binding [GO:0008289] QMIMKDK;SETAEELKKVAQELEEK 2 6 0.9653 -1.1598 0 0 0 9.37471 0 0 0 0 0 0 0 0 O14792 HS3S1_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) HS3ST1 3OST 3OST1 Homo sapiens (Human) "glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi lumen [GO:0005796] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; sulfotransferase activity [GO:0008146] DPSERVLSDYTQVFYNHMQK;FFPLRHIHIVDGDRLIR;LSPQINASNFYFNKTK 3 17.3 0.9789 -2.1139 0 0 0 0 0 0 8.72158 0 0 0 10.1752 0 O14793 GDF8_HUMAN Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hypoxia [GO:0071456]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of muscle hypertrophy [GO:0014741]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; negative regulation of skeletal muscle tissue growth [GO:0048632]; ovulation cycle process [GO:0022602]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to muscle activity [GO:0014850]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle satellite cell differentiation [GO:0014816]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] IEAIKIQILSK;LIKPMKDGTRYTGIR;TVLQNWLK;VTDTPKRSR;VVKAQLWIYLRPVETPTTVFVQILR;YPLTVDFEAFGWDWIIAPK 6 23.2 0.97524 -3.3788 5.47855 0 0 10.3159 11.8215 0 0 0 0 9.23216 0 0 O14795 UN13B_HUMAN Protein unc-13 homolog B (Munc13-2) (munc13) UNC13B UNC13 Homo sapiens (Human) "acrosomal vesicle exocytosis [GO:0060478]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; neuronal dense core vesicle exocytosis [GO:0099011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic vesicle priming [GO:0010808]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; syntaxin-1 binding [GO:0017075] AAEKSCK;DVFTVNKAAHVQQMK;ELSHLSKLKDHMVR;IDECVRQMADILGQVR 4 3.3 0.97485 -3.237 0 7.27938 0 0 0 0 0 0 0 10.5987 7.00899 0 O14796 SH21B_HUMAN SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) SH2D1B EAT2 Homo sapiens (Human) adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; leukocyte activation involved in immune response [GO:0002366]; positive regulation of innate immune response [GO:0045089]; positive regulation of natural killer cell mediated immunity [GO:0002717] cytosol [GO:0005829] protein-macromolecule adaptor activity [GO:0030674] DLPYYHGRLTK 1 8.3 0.88551 -0.181 0 0 0 9.06291 0 0 0 0 0 0 0 0 O14802 RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160) POLR3A Homo sapiens (Human) defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; magnesium ion binding [GO:0000287]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] FIKGVSEK;IKVRLPPPTILKPVTLWTGK;LTEIIFLNDVIKK;NELILTTESIMK 4 3.8 0.97898 -1.9638 0 13.8204 0 0 11.0345 0 11.866 0 4.41691 12.3752 12.428 8.26688 O14804 TAAR5_HUMAN Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; trimethylamine receptor activity [GO:1990081] HERKAAK;SLAGAAK 2 4.2 0.12647 0.35856 0 0 0 0 0 0 10.2716 0 0 11.0047 0 0 O14818 PSA7_HUMAN Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) PSMA7 HSPC Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]" identical protein binding [GO:0042802] ALLEVVQSGGK;DIVVLGVEK;LVIKALLEVVQSGGK 3 9.7 0.01217 0.85376 0 0 0 0 0 0 0 9.90806 0 0 0 7.35834 O14827 RGRF2_HUMAN Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) RASGRF2 GRF2 Homo sapiens (Human) long-term synaptic potentiation [GO:0060291]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; Ras protein signal transduction [GO:0007265]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085] IFTTAAVVLGK;SIPYEEFLGQGWMKLDKNER;TAEASRWHEK;VPQIRYASVERLLER 4 4.5 0.975 -3.1342 7.80645 11.143 0 0 0 7.06447 7.63626 0 0 0 0 10.4391 O14830 PPE2_HUMAN Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16) PPEF2 Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; detection of stimulus involved in sensory perception [GO:0050906]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AFKAAALIQRWYR;FAQDSEMKK;ISRVEESALR;TSRSSSIPCSGSLDGRELSR;VGLASSQLCYYQQK;VTHTLTMRQRISR 6 12.7 0.97681 -2.2392 0 0 12.2899 8.17857 0 0 0 0 0 9.60372 0 10.4002 O14832 PAHX_HUMAN "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" PHYH PAHX Homo sapiens (Human) 2-oxobutyrate catabolic process [GO:0019606]; 2-oxoglutarate metabolic process [GO:0006103]; fatty acid alpha-oxidation [GO:0001561]; isoprenoid metabolic process [GO:0006720]; methyl-branched fatty acid metabolic process [GO:0097089] 9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; phytanoyl-CoA dioxygenase activity [GO:0048244] DIWMFRAR;EVVGIAHKFFGAENSVNLK;MITKVQDFQEDK;NLVPDADIQRFR 4 15.1 0.97488 -3.2606 11.8005 0 0 9.25866 0 0 9.31123 0 9.27408 0 0 0 O14841 OPLA_HUMAN 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) OPLAH Homo sapiens (Human) glutathione metabolic process [GO:0006749] cytosol [GO:0005829] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] AQVAANQK;DIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQR;KNGRTVNLGGK;SQISTESFLHLR 4 5.5 0.97877 -1.9196 10.4355 7.05853 3.41427 0 0 0 0 10.2958 0 0 7.98857 0 O14842 FFAR1_HUMAN Free fatty acid receptor 1 (G-protein coupled receptor 40) FFAR1 GPR40 Homo sapiens (Human) "G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of interleukin-1 beta production [GO:0032691]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; response to fatty acid [GO:0070542]" plasma membrane [GO:0005886] bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289] GATAHAR 1 2.3 0.65186 0.17022 0 0 12.2057 0 0 0 0 0 0 0 0 0 O14862 AIM2_HUMAN Interferon-inducible protein AIM2 (Absent in melanoma 2) AIM2 Homo sapiens (Human) activation of innate immune response [GO:0002218]; AIM2 inflammasome complex assembly [GO:0140970]; brain development [GO:0007420]; cellular response to interferon-beta [GO:0035458]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; neuron cellular homeostasis [GO:0070050]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; pyroptosome complex assembly [GO:1904270]; pyroptotic inflammatory response [GO:0070269]; regulation of behavior [GO:0050795]; T cell homeostasis [GO:0043029]; tumor necrosis factor-mediated signaling pathway [GO:0033209] AIM2 inflammasome complex [GO:0097169]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] cysteine-type endopeptidase activator activity [GO:0140608]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling adaptor activity [GO:0035591] CLPVMVLK;NGEKLQLTSGVHSTIK 2 7 0.91909 -0.40243 0 0 0 10.5063 0 0 0 0 0 0 0 6.61049 O14867 BACH1_HUMAN Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of metabolic process [GO:0019222]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; heme binding [GO:0020037]; ligand-activated transcription factor activity [GO:0098531]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NVQTPQCKLRR 1 1.5 0.76972 0.056362 0 0 0 0 0 0 0 0 0 10.4675 0 0 O14874 BCKD_HUMAN "Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4)" BCKDK Homo sapiens (Human) amino acid catabolic process [GO:0009063]; branched-chain amino acid catabolic process [GO:0009083]; lipid biosynthetic process [GO:0008610]; negative regulation of amino acid metabolic process [GO:0045763]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity [GO:0047323]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] INGHVAAR;LTDFPPIK 2 3.9 0.95829 -1.0155 0 0 0 10.1585 0 9.82856 0 0 0 0 0 0 O14879 IFIT3_HUMAN Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) IFIT3 CIG-49 IFI60 IFIT4 ISG60 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802] ILPQLKCHFTWNLFK;SLVTWGNYAWVYYHLGR 2 6.5 0.80882 0.0090566 0 0 0 0 0 0 11.4034 7.6017 0 0 0 0 O14893 GEMI2_HUMAN Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) GEMIN2 SIP1 Homo sapiens (Human) "mRNA processing [GO:0006397]; negative regulation of RNA binding [GO:1905215]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]" cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681] CSEVRLLVVF 1 4 0.88483 -0.18126 0 0 0 0 0 0 0 10.6812 0 0 0 0 O14894 T4S5_HUMAN Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H) TM4SF5 Homo sapiens (Human) regulation of G1/S transition of mitotic cell cycle [GO:2000045] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] arginine binding [GO:0034618] AGGKGCCGAGCCGNR;GCCGAGCCGNRCR 2 8.6 0.92926 -0.4703 0 0 6.06357 0 3.95661 0 0 0 0 0 0 0 O14896 IRF6_HUMAN Interferon regulatory factor 6 (IRF-6) IRF6 Homo sapiens (Human) cell development [GO:0048468]; cranial skeletal system development [GO:1904888]; immune system process [GO:0002376]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" EFNLMYDGTK;EVPMNPVK;LLDVMDR;QPPFEIYLCFGEEWPDGKPLER 4 10.1 0.96515 -1.1196 0 0 4.50125 0 7.75782 0 0 0 0 0 0 0 O14901 KLF11_HUMAN Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) KLF11 FKLF TIEG2 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to peptide [GO:1901653]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AVDIMDICESILERK 1 2.9 0.90673 -0.27382 0 0 0 0 0 0 0 0 0 9.41509 0 0 O14905 WNT9B_HUMAN Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15) WNT9B WNT14B WNT15 UNQ6973/PRO21956 Homo sapiens (Human) "branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cellular response to starvation [GO:0009267]; collecting duct development [GO:0072044]; cornea development in camera-type eye [GO:0061303]; embryonic cranial skeleton morphogenesis [GO:0048701]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; in utero embryonic development [GO:0001701]; kidney rudiment formation [GO:0072003]; male genitalia development [GO:0030539]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesonephric duct formation [GO:0072181]; metanephric tubule formation [GO:0072174]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of stem cell population maintenance [GO:1902455]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; regulation of asymmetric cell division [GO:0009786]; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003339]; regulation of tube size [GO:0035150]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" extracellular region [GO:0005576]; extracellular space [GO:0005615] co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] ADAHNTHVGIK;EVLTPFPGLGTAAAPAQGGAHLK 2 9.5 0.75223 0.076978 0 0 0 0 0 0 0 0 0 10.0214 0 6.31976 O14907 TX1B3_HUMAN Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) TAX1BP3 TIP1 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of Wnt signaling pathway [GO:0030178]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway [GO:0016055] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013] AVQQSMLS;SEEVVRLLVTRQSLQK 2 19.4 0.9323 -0.49271 0 0 0 0 0 0 2.0274 2.97039 0 0 0 9.53354 O14908 GIPC1_HUMAN PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) GIPC1 C19orf3 GIPC RGS19IP1 Homo sapiens (Human) cellular response to interleukin-7 [GO:0098761]; chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506] actin binding [GO:0003779]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] ELYGKIAEAFRLPTAEVMFCTLNTHK 1 7.8 0.68401 0.16504 0 0 0 0 0 0 0 7.50653 0 0 0 0 O14917 PCD17_HUMAN Protocadherin-17 (Protocadherin-68) PCDH17 PCDH68 PCH68 Homo sapiens (Human) adult behavior [GO:0030534]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of synaptic transmission [GO:0050805]; presynaptic active zone assembly [GO:1904071]; regulation of synaptic vesicle clustering [GO:2000807]; synaptic membrane adhesion [GO:0099560] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium ion binding [GO:0005509] GGGGRSK;QQFVQSSSTFKDPER 2 1.9 0.94129 -0.58929 0 13.1882 0 0 0 0 10.4082 11.0248 10.7415 0 0 0 O14921 RGS13_HUMAN Regulator of G-protein signaling 13 (RGS13) RGS13 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activity [GO:0003924] IVYMHMERDSYPRFLK 1 10.1 0.43378 0.19481 9.44429 0 0 0 0 0 0 0 0 0 0 0 O14924 RGS12_HUMAN Regulator of G-protein signaling 12 (RGS12) RGS12 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase regulator activity [GO:0030695] ASHEDVVK;LSGKSKSGR;SFGRSKR;SLSESAATR;VLVVDLGGSSSR 5 3.1 0.97429 -3.8158 0 0 0 0 0 0 0 0 0 5.84001 0 0 O14929 HAT1_HUMAN Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) HAT1 KAT1 Homo sapiens (Human) chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; nucleosome assembly [GO:0006334]; subtelomeric heterochromatin formation [GO:0031509] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996] LAEYKCNTNTAIELKLVR;LLVTDMSDAEQYR;LLVTDMSDAEQYRSYRLDIK;LRDFVLVKLCQDLPCFSR 4 13.4 0.97979 -1.5396 0 0 0 0 0 0 9.61991 10.3529 10.9205 8.64717 0 0 O14936 CSKP_HUMAN Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 Homo sapiens (Human) calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; establishment of localization in cell [GO:0051649]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300] actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; vesicle [GO:0031982] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanylate kinase activity [GO:0004385]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; neurexin family protein binding [GO:0042043]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling receptor binding [GO:0005102] VGTPHFMAPEVVK 1 1.4 0.87852 -0.13944 0 0 0 0 0 0 0 0 0 0 0 10.6865 O14948 TFEC_HUMAN Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) TFEC BHLHE34 TCFEC TFECL Homo sapiens (Human) cellular response to heat [GO:0034605]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ELEHRQK;WLQKEQQR 2 4.3 0.97995 -1.8388 0 0 0 0 0 0 11.6047 9.56666 0 0 0 11.3876 O14949 QCR8_HUMAN Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) UQCRQ Homo sapiens (Human) "cellular respiration [GO:0045333]; cerebellar Purkinje cell layer development [GO:0021680]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; midbrain development [GO:0030901]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; pons development [GO:0021548]; pyramidal neuron development [GO:0021860]; subthalamus development [GO:0021539]; thalamus development [GO:0021794]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] NPAAYENDK;VVPQFVVFYLIYTWGTEEFERSK 2 39 0.95525 -0.94987 0 0 0 0 0 0 9.23479 0 0 0 9.69148 0 O14957 QCR10_HUMAN Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein) UQCR11 UQCR Homo sapiens (Human) "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] electron transfer activity [GO:0009055] LILDWVPYINGKFKK 1 26.8 0.92939 -0.46561 0 0 0 0 8.47054 9.01625 0 0 10.0615 0 0 0 O14958 CASQ2_HUMAN "Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)" CASQ2 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; detection of calcium ion [GO:0005513]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; protein polymerization [GO:0051258]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of heart rate [GO:0002027]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; sequestering of calcium ion [GO:0051208]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; junctional sarcoplasmic reticulum membrane [GO:0014701]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium ion sequestering activity [GO:0140314]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803] AIGFVMVDAK;GVAKKLSLK 2 4.8 0.98024 -1.7151 0 0 0 0 0 9.56569 0 0 0 0 0 10.3328 O14960 LECT2_HUMAN Leukocyte cell-derived chemotaxin-2 (LECT-2) (hLECT2) LECT2 Homo sapiens (Human) chemotaxis [GO:0006935]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; extracellular space [GO:0005615] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LGTLLPLQK 1 6 0.928 -0.45728 0 0 0 0 0 0 0 0 0 7.9279 0 0 O14965 AURKA_HUMAN Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; apoptotic process [GO:0006915]; cell division [GO:0051301]; centrosome localization [GO:0051642]; cilium disassembly [GO:0061523]; G2/M transition of mitotic cell cycle [GO:0000086]; liver regeneration [GO:0097421]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]; regulation of cytokinesis [GO:0032465]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to wounding [GO:0009611]; spindle assembly involved in female meiosis I [GO:0007057]; spindle organization [GO:0007051] axon hillock [GO:0043203]; basolateral plasma membrane [GO:0016323]; centriole [GO:0005814]; centrosome [GO:0005813]; chromosome passenger complex [GO:0032133]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; germinal vesicle [GO:0042585]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular function activator activity [GO:0140677]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625] FILALKVLFKAQLEK;LSKFDEQR 2 5.7 0.96879 -1.3316 11.437 6.71012 0 0 0 0 0 0 4.95061 0 0 0 O14966 RAB7L_HUMAN Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) RAB29 RAB7L1 Homo sapiens (Human) "cell differentiation [GO:0030154]; cellular detoxification [GO:1990748]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; modulation by host of viral process [GO:0044788]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110]" cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773] dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267] SSSWSCC 1 3.4 0.9145 -0.3362 4.99508 0 0 0 0 0 0 0 0 0 0 0 O14974 MYPT1_HUMAN Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) cellular response to xenobiotic stimulus [GO:0071466]; centrosome cycle [GO:0007098]; mitotic cell cycle [GO:0000278]; negative regulation of catalytic activity [GO:0043086]; neuron projection morphogenesis [GO:0048812]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of nucleocytoplasmic transport [GO:0046822]; signal transduction [GO:0007165] A band [GO:0031672]; actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; contractile muscle fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; PTW/PP1 phosphatase complex [GO:0072357]; stress fiber [GO:0001725]; Z disc [GO:0030018] 14-3-3 protein binding [GO:0071889]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] IESLEQEKVDEEEEGK;ISEMEEELK;ISPKEEER;KDESSCSSEEDEEDDSESEAETDK;LASTSDIEEK;LSSSLDNKEKEK;SLLEMEK;VDEEEEGKKDESSCSSEEDEEDDSESEAETDK 8 8.3 0.97473 -3.2407 10.3738 0 0 0 8.51033 0 11.1755 0 0 9.83998 6.08545 0 O14975 S27A2_HUMAN "Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty-acyl-CoA biosynthetic process [GO:0046949]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760] cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; enzyme binding [GO:0019899]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleate transmembrane transporter activity [GO:1901480]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; very long-chain fatty acid-CoA ligase activity [GO:0031957] ITQLTPFNGYAGAKAQTEK;LFQHIADYLPSYARPR;SEVTFSTPALYIYTSGTTGLPK 3 9.2 0.86455 -0.085544 0 0 0 0 8.55294 0 0 9.81933 0 0 11.4328 0 O14976 GAK_HUMAN Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) GAK DNAJC26 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; intracellular transport [GO:0046907]; negative regulation of neuron projection development [GO:0010977]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis [GO:0006898]; regulation of clathrin coat assembly [GO:1905443]; synaptic vesicle uncoating [GO:0016191] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; vesicle [GO:0031982] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; cyclin binding [GO:0030332]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-folding chaperone binding [GO:0051087]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HPGHYAVYNLSPRTYRPSR;LQAKMASMK 2 2.1 0.9547 -0.90221 0 0 0 0 0 0 0 0 0 0 7.03188 0 O14977 AZIN1_HUMAN Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor) AZIN1 OAZI OAZIN Homo sapiens (Human) negative regulation of protein catabolic process [GO:0042177]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ornithine decarboxylase activator activity [GO:0042978]; ornithine decarboxylase activity [GO:0004586] VVENDKFPSGVEK 1 2.9 0.88765 -0.18325 0 0 0 0 8.25593 0 0 0 0 0 0 0 O14978 ZN263_HUMAN Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) ZNF263 FPM315 ZKSCAN12 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" LWDPSVQSCK 1 1.5 0.93639 -0.51828 0 0 0 0 0 0 0 11.1357 0 0 0 0 O14979 HNRDL_HUMAN Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) HNRNPDL HNRPDL JKTBP Homo sapiens (Human) regulation of gene expression [GO:0010468]; RNA processing [GO:0006396] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] GAAAGGR 1 1.7 0.81813 -0.017417 0 0 0 0 0 0 0 0 11.5444 0 0 0 O14980 XPO1_HUMAN Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) XPO1 CRM1 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein export from nucleus [GO:0046825]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254] annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] EPEVLSTMAIIVNK;LISGWVSR 2 2.1 0.15812 0.34856 0 0 0 0 0 0 0 10.271 0 0 0 0 O14981 BTAF1_HUMAN TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) BTAF1 TAF172 Homo sapiens (Human) negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA-templated transcription [GO:0045892] intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; TBP-class protein binding [GO:0017025]; transcription coregulator activity [GO:0003712]" DAVETNEK;LLQQCTTR;QEPTSESSMEDSPTTERLNFDRFDICR;QPTLQAAELIDSEFRAGMSNR 4 3.5 0.96675 -1.2794 7.29673 10.3663 0 0 0 0 0 0 0 0 5.45085 0 O14983 AT2A1_HUMAN "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)" ATP2A1 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; calcium ion import [GO:0070509]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; maintenance of mitochondrion location [GO:0051659]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of striated muscle contraction [GO:0045988]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; positive regulation of cardiac muscle cell contraction [GO:0106134]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cardiac conduction [GO:1903779]; regulation of striated muscle contraction [GO:0006942]; relaxation of skeletal muscle [GO:0090076]; response to endoplasmic reticulum stress [GO:0034976] calcium channel complex [GO:0034704]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; H zone [GO:0031673]; I band [GO:0031674]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calcium-dependent ATPase activity [GO:0030899]; P-type calcium transporter activity [GO:0005388]; protein homodimerization activity [GO:0042803] ACCFARVEPSHK;EWGTGRDTLR;TASEMVLADDNFSTIVAAVEEGR;VERANACNSVIRQLMK;VIMITGDNK;YGLNELPAEEGK 6 8.2 0.97809 -1.9453 0 0 9.25753 0 0 10.3277 0 0 0 0 9.00169 0 O14986 PI51B_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta) PIP5K1B STM7 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; uropod [GO:0001931] 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742] ALVYDGDTVSVHRPSFYADRFLKFMNSR;LMKKLEHSWK;TLQRDCRVLESFK 3 9.4 0.97425 -1.3944 0 0 0 0 5.63105 0 11.5189 0 0 0 9.99591 0 O15013 ARHGA_HUMAN Rho guanine nucleotide exchange factor 10 ARHGEF10 KIAA0294 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; kinesin binding [GO:0019894] APDGSWDSEPQKVIK;EPGAPPDPETPAVR;GMVSYHAHNSPVK;KEDEIRAADCCR;QLSHDLTRLKEHYEK;YILGSVVDSEK 6 5.8 0.97514 -4.0382 11.2821 0 0 8.19894 0 9.64523 8.15173 0 10.1824 0 10.5847 10.411 O15014 ZN609_HUMAN Zinc finger protein 609 ZNF609 KIAA0295 Homo sapiens (Human) muscle organ development [GO:0007517]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] AKEPGADPAK;EGKSKSK 2 1.2 0.9807 -1.6083 0 0 2.79921 10.3563 0 7.28207 0 0 0 6.55798 0 0 O15015 ZN646_HUMAN Zinc finger protein 646 ZNF646 KIAA0296 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QLASHQRVHMERR;QSHQTGHFGCQACSK;VFRLPRELLEHQQSHEGER;YPNLMALRNHVR 4 3.2 0.95169 -0.67068 12.131 0 0 0 0 5.619 0 0 0 0 0 11.2316 O15016 TRI66_HUMAN Tripartite motif-containing protein 66 TRIM66 C11orf29 KIAA0298 Homo sapiens (Human) chromatin [GO:0000785]; nucleus [GO:0005634] zinc ion binding [GO:0008270] ENQSIRAFNSEHKIPYVR;FTWEPNFWTK 2 2.1 0.84724 -0.061705 11.5604 0 0 0 0 0 0 7.71129 0 0 0 0 O15018 PDZD2_HUMAN PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] PDZD2 AIPC KIAA0300 PDZK3 Homo sapiens (Human) cell adhesion [GO:0007155] cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ALSMPDLDK;ANSLVTLGSHR;ESPVTDIDSFIKELDASAAR;LSGGVHR;STYQESK;SVAVHDALCVEVLK;VQATSVKVTVAGFQPGGAVEKESLGK 7 3.3 0.97512 -3.134 9.96252 0 9.75315 0 0 0 10.3324 0 9.16017 9.03205 0 9.77035 O15020 SPTN2_HUMAN "Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)" SPTBN2 KIAA0302 SCA5 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; vesicle-mediated transport [GO:0016192] apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918] DALLLWCQMK;DLTGALR;FLWEVGEAEAWVR;LEQLAARFDRK;LTALEEREK;QEKLEQLAAR;RLQDFLR;SKDGRER;VGDLYSDLR 9 3.2 0.97484 -3.7179 0 0 0 0 6.39919 0 0 10.4137 0 0 11.5985 10.9674 O15021 MAST4_HUMAN Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1) MAST4 KIAA0303 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ADGFPEK;AQRERLQIPGLTLDLTPR;AWAPGGK;DLKPDNLLVTSMGHIK;EPATQSLGGSSR;INKQNLILR;KAQPAGEGR;LLTCLGQNLHSPDLARPR;NTPMRPRSRSLSPGR;QLVRKILIVIARPAR;SLQPPGIESEKSEK 11 5.7 0.97317 -2.9337 0 0 0 9.9935 10.5732 10.8123 0 0 12.1438 9.27657 5.27434 8.51471 O15027 SC16A_HUMAN Protein transport protein Sec16A (SEC16 homolog A) (p250) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi to plasma membrane transport [GO:0006893]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of COPII vesicle coating [GO:0003400]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471] DNNWRYDPR;EPKKGESWFFR;FYQQVTK;GLANPEPAPEPK;RSVHSEHSAR 5 2.1 0.97368 -2.9829 0 0 9.79902 3.78251 0 9.11194 0 10.5217 0 0 0 10.3894 O15031 PLXB2_HUMAN Plexin-B2 (MM1) PLXNB2 KIAA0315 Homo sapiens (Human) brain development [GO:0007420]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of translation [GO:0045727]; receptor-mediated endocytosis [GO:0006898]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] HNIQDEDTIHIWK;SKSCVAVTSAQPQNMSRR;SQLEGLEESVRDRCK;VTLNGVPCK;YHECREASPNPEDGIVR 5 3.9 0.93673 -0.55856 0 0 0 0 8.4543 0 0 8.36562 8.90725 0 0 4.73276 O15033 AREL1_HUMAN Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1) AREL1 KIAA0317 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein K11-linked ubiquitination [GO:0070979]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]; regulation of inflammatory response [GO:0050727]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LGGLNVAYSPYYK 1 1.6 0.87802 -0.13598 0 0 0 0 0 0 0 0 11.6974 0 0 0 O15034 RIMB2_HUMAN RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) neuromuscular synaptic transmission [GO:0007274] plasma membrane [GO:0005886]; synapse [GO:0045202] CRTQSEQFNLLSR;DADGFYRGETCAR;GSELGKQPHCCHGDEYHTESSR;ISVQCVTSR;KITLIKQLAK;LNMAACTYRISVQCVTSR;SESDMENER;YKYQFFNLRPNMAYK 8 9.5 0.97552 -3.5702 6.74308 6.98128 7.87154 7.07264 0 0 9.97642 11.6682 11.8643 4.65421 0 0 O15037 KHNYN_HUMAN Protein KHNYN (KH and NYN domain-containing protein) KHNYN KIAA0323 Homo sapiens (Human) cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] GDCGDRGDVGDR;VPSPPPAPEPPWHCGDRGDCGDRGDVGDR 2 4.3 0.073718 0.4079 0 0 0 0 9.62573 0 0 0 0 0 0 0 O15040 TCPR2_HUMAN Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) autophagy [GO:0006914]; protein exit from endoplasmic reticulum [GO:0032527] cytoplasm [GO:0005737] GTASATK;QLRRFDVTGIHK 2 1.3 0.87343 -0.11167 11.0304 7.91982 0 0 0 6.50484 0 0 0 0 0 0 O15041 SEM3E_HUMAN Semaphorin-3E SEMA3E KIAA0331 SEMAH Homo sapiens (Human) axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sprouting angiogenesis [GO:0002040]; synapse organization [GO:0050808] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215] ALEAENNAHAIYTR;FHHCDMYGSACADCCLARDPYCAWDGISCSR;VIWFVQKGR 3 7 0.9647 -1.1192 7.08979 0 0 0 7.13996 0 0 6.08659 0 0 0 11.3814 O15042 SR140_HUMAN U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2SURP KIAA0332 SR140 Homo sapiens (Human) RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2 snRNP [GO:0005686] RNA binding [GO:0003723] GGVVNAAK;HSTSPSPSR;NLLALIHRMIEFVVR;TDEERARER 4 4 0.98105 -1.7 0 0 0 0 9.11377 0 9.65508 9.57973 2.95964 0 0 0 O15042 SR140_HUMAN U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2SURP KIAA0332 SR140 Homo sapiens (Human) RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2 snRNP [GO:0005686] RNA binding [GO:0003723] HSTSPSPSR;ILRRNLLALIHR;NLLALIHRMIEFVVR 3 4.5 0.30282 0.24954 0 10.0833 3.76998 0 2.5614 0 0 0 3.01984 0 0 0 O15047 SET1A_HUMAN Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) SETD1A KIAA0339 KMT2F SET1 SET1A Homo sapiens (Human) brain development [GO:0007420]; DNA damage response [GO:0006974]; methylation [GO:0032259]; regulation of chromatin organization [GO:1902275]; regulation of hematopoietic stem cell differentiation [GO:1902036] chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] beta-catenin binding [GO:0008013]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] DEEDDEEDEEDEDR;EEKAKPFQNAAKQQAK;FPLEDNKIPCLCGTESCR;FQGSGAATETAESRR 4 3.7 0.95503 -0.80597 0 11.7031 0 13.0846 0 0 0 7.00865 6.51964 0 5.07934 0 O15049 N4BP3_HUMAN NEDD4-binding protein 3 (N4BP3) N4BP3 KIAA0341 Homo sapiens (Human) innate immune response [GO:0045087]; nervous system development [GO:0007399] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425] GQEQALR 1 1.3 0.937 -0.54941 0 0 0 0 0 0 0 0 9.05796 0 0 0 O15050 TRNK1_HUMAN TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) ATSHYKPLDPNIHKLQDLRDENFPLFVTSK;DARDWLMKTETR;GSIVRGLYYEEVRLNR;GVAFRFSDLR;IIATEQNTCAMEKSGR;ILGLAPGGLEILLSLVRALK;ILGLAPGGLEILLSLVRALKR;KNDSLLLAWNKALMENR;LEVEPGK;LHQPYEAARMFFEGLRLVQR;LLHQEEDNYNRELK;LVNILILSVRDAR;NTIDKQCAVR;QLEYLELAK;REEAALLMK;RLAEAADLLNR;SLFHYASRNTIDK;VVKRVLVAVNVK 18 7.9 0.97474 -3.7566 13.3243 7.40207 9.47822 8.76255 10.2352 10.724 11.2225 7.82623 6.51196 7.89336 0 9.14792 O15054 KDM6B_HUMAN Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) KDM6B JMJD3 KIAA0346 Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; cell fate commitment [GO:0045165]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; endothelial cell differentiation [GO:0045446]; hippocampus development [GO:0021766]; inflammatory response to antigenic stimulus [GO:0002437]; mesodermal cell differentiation [GO:0048333]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to activity [GO:0014823]; response to fungicide [GO:0060992] MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] MLDESIRK;YGGSFAELGPR 2 1.2 0.94713 -0.66257 0 0 0 0 0 0 0 0 0 0 0 7.69042 O15055 PER2_HUMAN Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) PER2 KIAA0347 Homo sapiens (Human) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; glycogen biosynthetic process [GO:0005978]; lactate biosynthetic process [GO:0019249]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; neural retina development [GO:0003407]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of vasoconstriction [GO:0019229]; response to ischemia [GO:0002931]; white fat cell differentiation [GO:0050872] Cry-Per complex [GO:1990512]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222] ATPPSAMGRASPPLFQSR;LKLLQKLQPR;NTSGIDSPWK;QPCACPATRATPPSAMGR;TLKELKVHLPADK 5 4.8 0.97331 -2.5582 8.01061 0 0 0 0 8.78192 0 0 0 12.464 5.49566 0 O15056 SYNJ2_HUMAN "Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)" SYNJ2 KIAA0348 Homo sapiens (Human) membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; synaptic vesicle endocytosis [GO:0048488] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; RNA binding [GO:0003723]" LLGRLGAEGDCSVLLEAR;LLNNTWLSK;LLPGAPQQPPK;RPPPRVPAIKKPTLR;VGKLKDGAR;YDVGSAAYDTSDKCRTPAWTDR 6 5.6 0.97925 -1.8989 0 0 0 0 0 0 0 11.1872 0 8.52595 0 7.20643 O15060 ZBT39_HUMAN Zinc finger and BTB domain-containing protein 39 ZBTB39 KIAA0352 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RIHTGEKPYQCK 1 1.7 0.67411 0.16713 0 0 0 0 0 0 0 0 0 0 0 9.46007 O15061 SYNEM_HUMAN Synemin (Desmuslin) SYNM DMN KIAA0353 SYN Homo sapiens (Human) fast-twitch skeletal muscle fiber contraction [GO:0031443]; intermediate filament cytoskeleton organization [GO:0045104] adherens junction [GO:0005912]; costamere [GO:0043034]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofilament cytoskeleton [GO:0060053]; sarcolemma [GO:0042383] intermediate filament binding [GO:0019215]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166] AVSSQTNVR;DGAVGEK;EVGLKGK;GISSKEPR;SLRQQLDELSWATALAEGER;VIDCLEDEKATLTLAMADWLR 6 4.6 0.97942 -1.8483 0 11.2392 11.1843 0 10.3504 0 0 0 11.2867 0 0 9.26224 O15063 GRRE1_HUMAN Granule associated Rac and RHOG effector protein 1 (GARRE1) GARRE1 KIAA0355 Homo sapiens (Human) Rac protein signal transduction [GO:0016601] cytosol [GO:0005829]; P-body [GO:0000932] CCR4-NOT complex binding [GO:1905762]; small GTPase binding [GO:0031267] FLLGGSK;QAQHGRRPGNPR;TFSKLTSRFTK;YCCSAQDSKMDYK 4 4 0.97491 -3.2355 0 0 0 0 0 0 15.0703 9.7149 10.7154 14.9426 15.1162 13.026 O15066 KIF3B_HUMAN "Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]" KIF3B KIAA0359 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; opsin transport [GO:0036372]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467]; vesicle-mediated transport [GO:0016192] axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; plus-end kinesin complex [GO:0005873] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267] GTAHEMPKTFTFDAVYDWNAK;LELKERPDTGVYVK;LGQVSVK;NPKGTAHEMPK;REREIQQQMESR;YRAENIVLLELDMPSR 6 9.8 0.97022 -1.3337 9.95728 9.90087 9.86836 9.13047 0 0 11.2928 11.0311 10.3478 9.29112 0 0 O15067 PUR4_HUMAN Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) PFAS KIAA0361 Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642] AGAELRR;ANQELGLALDSWDLDFYTKR;HWFFKGQLHVDGQK;IVLVDDRECPVRR;LPAVASK;REWIKPIMFSGGIGSMEADHISK 6 6.3 0.94003 -0.58141 0 12.3679 7.09508 9.95361 0 0 0 0 0 6.62476 8.19825 11.5631 O15068 MCF2L_HUMAN Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) MCF2L KIAA0362 OST Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol binding [GO:0035091] ALSLDGEQLIGNK;DLASFEEKSGVAVER;GGPDALR;GPYRRAK;ISVAEMK;RHVMSELLDTER 6 5.5 0.98108 -1.6914 0 9.58252 10.9238 0 0 0 0 0 0 0 0 10.501 O15072 ATS3_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; in utero embryonic development [GO:0001701]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; supramolecular fiber organization [GO:0097435]; vascular endothelial growth factor production [GO:0010573] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] CHLYCQSKETGDVAYMK;GKQMEEEKGR 2 2.2 0.77708 0.042014 8.48744 9.70434 0 0 0 8.97585 0 9.08356 0 0 0 0 O15075 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) DCLK1 DCAMKL1 DCDC3A KIAA0369 Homo sapiens (Human) axon extension [GO:0048675]; central nervous system development [GO:0007417]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of postsynapse assembly [GO:0150052]; response to virus [GO:0009615] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IASSSRR;LVTIIRSGVKPRK;STTKSPGPSRR 3 4.2 0.9301 -0.46961 0 9.4005 0 0 9.62954 0 0 0 2.138 0 0 0 O15078 CE290_HUMAN Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) CEP290 BBS14 KIAA0373 NPHP6 Homo sapiens (Human) camera-type eye development [GO:0043010]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; eye photoreceptor cell development [GO:0042462]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; otic vesicle formation [GO:0030916]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; pronephros development [GO:0048793]; protein transport [GO:0015031]; regulation of establishment of protein localization [GO:0070201] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580] identical protein binding [GO:0042802] ATCKSLEEK;EGEVFTLTKQLNTLKDLFAK;EMEKNTCIIEDLKNELQR;EQALYYAR;EVDLERQLDIFDR;EYLSEKETWKTESK;FLRNEICQLEK;FLRNEICQLEKQLEQK;IDHLEKETSLLR;IIAENERLR;KNILLEEKVK;KNYELIQYLDEIQTLTEANEK;LEDQVQQDAIK;LIAELGRKEMEPK;LILSSKDDEIIEYQQMLHNLR;LKELVEENK;MTVQLEETGK;NEFLSRELIEKER;QENVIHLFRITQSLMK 19 9.8 0.97865 -9.9747 0 11.2692 11.2732 7.12928 9.44452 0 10.9929 11.1128 10.269 10.2898 9.80319 12.1147 O15083 ERC2_HUMAN ERC protein 2 ERC2 KIAA0378 Homo sapiens (Human) maintenance of presynaptic active zone structure [GO:0048790]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; synaptic vesicle priming [GO:0016082] cytoskeleton [GO:0005856]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] structural constituent of presynaptic active zone [GO:0098882] DSTMLDLQAQLKELQR;EAHLANLR;ELQRENDLLRK;ENIHLREELHR;EVENEKNDKDK;KIENLQEQLR;QAKELFLLRK;QIEVYKSHSKFMK;SLEDDNERTRR;TITNLEGSPSRSPR;TKIDQLK 11 12.3 0.97811 -7.0261 0 9.60498 0 9.89815 0 7.5601 10.6554 0 0 0 0 11.1628 O15085 ARHGB_HUMAN Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) ARHGEF11 KIAA0380 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; establishment of cell polarity [GO:0030010]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AEVAGSK;FPSLSESLMNR;ITGPKPLQDPEVQK;LTKYPLLLESIIK 4 3 0.97368 -1.4026 0 0 0 5.15263 0 0 9.06684 9.94713 0 0 0 11.0199 O15090 ZN536_HUMAN Zinc finger protein 536 ZNF536 KIAA0390 Homo sapiens (Human) negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DCPYCGK;EELDRHIRILHKPYK;ETLGEQK;EYVLVGADGSKQKMPADLVHSTK;GENNDEEDVETEPEMMTKPLSALSK;LGNLGKGRGR;SLGSAMKDCPYCGK 7 7.2 0.95241 -0.75353 10.5993 0 9.0227 10.248 10.9199 8.99348 0 0 0 10.9934 0 0 O15091 MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) PRORP KIAA0391 MRPP3 Homo sapiens (Human) mitochondrial tRNA 5'-end processing [GO:0097745]; tRNA 5'-leader removal [GO:0001682] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526] ACLPDAKTQRLFFK;ATNLIAKARYLR;LLDILSYLR 3 6 0.91578 -0.39396 6.96798 0 0 0 0 8.63285 0 0 0 0 7.31433 14.5845 O15105 SMAD7_HUMAN Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7) SMAD7 MADH7 MADH8 Homo sapiens (Human) adherens junction assembly [GO:0034333]; anatomical structure morphogenesis [GO:0009653]; artery morphogenesis [GO:0048844]; beta-catenin destruction complex disassembly [GO:1904886]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ossification [GO:0030279]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of chondrocyte hypertrophy [GO:1903043]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein stabilization [GO:0050821]; protein-containing complex disassembly [GO:0032984]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle contraction [GO:0055117]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; response to laminar fluid shear stress [GO:0034616]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular septum morphogenesis [GO:0060412] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] activin receptor binding [GO:0070697]; beta-catenin binding [GO:0008013]; collagen binding [GO:0005518]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IGCGIQLTR 1 2.1 0.9157 -0.39511 0 0 0 0 0 0 0 11.6952 0 0 0 0 O15111 IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) CHUK IKKA TCF16 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to acetate [GO:0010034]; response to amino acid [GO:0043200]; response to cholecystokinin [GO:0061847]; response to hydroperoxide [GO:0033194]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459] IAIKSCR;KPASQCVLDGVRGCDSYMVYLFDKSK;TVYEGPFASR 3 5.8 0.94853 -0.66422 11.4652 11.6316 0 0 0 9.13684 10.8437 0 0 10.1984 0 0 O15117 FYB1_HUMAN FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) FYB1 FYB SLAP130 Homo sapiens (Human) immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852] actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102] SIREKPK;TARGSYGYIK;VGFLKPVGPKPINLPK;VTTSITSKKWGTR 4 5.5 0.98094 -1.7108 7.75876 0 0 9.21936 0 9.11925 6.37306 0 0 0 0 0 O15118 NPC1_HUMAN NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein) NPC1 Homo sapiens (Human) adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; macroautophagy [GO:0016236]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] GTERERLLNF 1 0.8 0.95578 -0.87552 0 0 0 0 0 0 0 0 0 9.89019 0 0 O15119 TBX3_HUMAN T-box transcription factor TBX3 (T-box protein 3) TBX3 Homo sapiens (Human) "animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell fate commitment [GO:0060923]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion formation [GO:0003272]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; forelimb morphogenesis [GO:0035136]; heart looping [GO:0001947]; hepatoblast differentiation [GO:0061017]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein complex stability [GO:0061635]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; semicircular canal morphogenesis [GO:0048752]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; smooth muscle cell differentiation [GO:0051145]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; ureteric peristalsis [GO:0072105]; ventricular septum morphogenesis [GO:0060412]" chromatin [GO:0000785]; cilium [GO:0005929]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DLCPSEGESDAEAESKEEHGPEACDAAK;HPFLNLNTMRPRLR;IDNNPFAKGFRDTGNGR;ITQLKIDNNPFAKGFR;VVTFHKLK 5 9.7 0.97641 -2.1833 0 7.48317 0 0 0 9.15175 0 0 0 0 0 0 O15120 PLCB_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta) AGPAT2 Homo sapiens (Human) CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; response to xenobiotic stimulus [GO:0009410]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] ENVPIVPVVYSSFSSFYNTKK;TVENMSIIGWFVRSFKYFYGLR 2 17.5 0.95461 -0.90779 0 0 0 0 0 0 6.47142 0 0 0 9.22417 0 O15121 DEGS1_HUMAN Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) DEGS1 DES1 MLD MIG15 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] electron transfer activity [GO:0009055]; retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284] SLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWK 1 10.2 0.83366 -0.027246 0 0 0 0 0 0 7.32859 0 0 0 0 0 O15123 ANGP2_HUMAN Angiopoietin-2 (ANG-2) ANGPT2 Homo sapiens (Human) angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; blood coagulation [GO:0007596]; cellular response to growth factor stimulus [GO:0071363]; gene expression [GO:0010467]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; positive regulation of angiogenesis [GO:0045766]; positive regulation of coagulation [GO:0050820]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; Tie signaling pathway [GO:0048014] cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] GSGYSLK 1 1.4 0.91563 -0.33308 0 0 0 0 6.15451 0 0 0 0 0 0 0 O15130 NPFF_HUMAN Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)] NPFF Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; neuropeptide signaling pathway [GO:0007218] axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perikaryon [GO:0043204]; postsynapse [GO:0098794] G protein-coupled receptor binding [GO:0001664]; neuropeptide activity [GO:0160041]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102] NEWLSPR 1 6.2 0.93715 -0.55357 0 0 0 0 0 0 0 0 9.57809 0 0 9.03202 O15131 IMA6_HUMAN Importin subunit alpha-6 (Karyopherin subunit alpha-5) KPNA5 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] DAMASPGK;VVSPALR 2 2.8 0.93978 -0.57831 10.4655 0 0 0 0 0 0 0 0 0 0 0 O15143 ARC1B_HUMAN Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) ARPC1B ARC41 Homo sapiens (Human) Arp2/3 complex-mediated actin nucleation [GO:0034314]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627] actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; tubulobulbar complex [GO:0036284] actin binding [GO:0003779]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200] IFSAYIK;INRAARCVR;NSVSQISVLSGGK;VISICYFEQENDWWVCK 4 12.4 0.91565 -0.39646 0 0 0 11.1113 9.86141 0 9.11127 10.0049 0 10.2589 0 0 O15144 ARPC2_HUMAN Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) ARPC2 ARC34 PRO2446 Homo sapiens (Human) actin filament polymerization [GO:0030041]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; muscle cell projection membrane [GO:0036195]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; site of double-strand break [GO:0035861]; synaptic vesicle membrane [GO:0030672] actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200] ASHTAPQVLFSHREPPLELK 1 6.7 0.88987 -0.20845 0 0 0 0 0 0 0 8.02414 0 0 0 0 O15146 MUSK_HUMAN "Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; memory [GO:0007613]; neuromuscular junction development [GO:0007528]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340] neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; Wnt-protein binding [GO:0017147] IIEGLKAVLPCTTMGNPKPSVSWIKGDSPLR;MKPKITRPPINVKIIEGLK 2 5.1 0.74817 0.084259 0 4.56139 0 0 7.39926 10.5067 0 0 0 0 0 0 O15151 MDM4_HUMAN Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX Homo sapiens (Human) "atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; regulation of cell cycle [GO:0051726]; ventricular septum development [GO:0003281]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DWYSDCSK 1 1.6 0.87857 -0.14057 0 0 0 0 0 0 0 0 4.09618 0 0 0 O15156 ZBT7B_HUMAN Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) ZBTB7B ZBTB15 ZFP67 ZNF857B Homo sapiens (Human) "adaptive thermogenesis [GO:1990845]; ectoderm development [GO:0007398]; lactation [GO:0007595]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of gene expression [GO:0010629]; negative regulation of NK T cell proliferation [GO:0051141]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NK T cell differentiation [GO:0001865]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of SREBP signaling pathway [GO:2000640]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; transcription by RNA polymerase II [GO:0006366]" nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GSPEDDLIGIPFPDHSSELLSCLNEQR 1 5 0.82365 -0.018145 0 0 0 6.66021 0 9.6209 0 0 0 0 0 0 O15164 TIF1A_HUMAN Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; epithelial cell proliferation [GO:0050673]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of gene expression [GO:0010628]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; response to peptide hormone [GO:0043434]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; euchromatin [GO:0000791]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726] chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DCQLLEHKEHR;HIIDNFFVK 2 1.9 0.79513 0.015567 0 0 0 0 0 0 0 0 0 10.8136 0 0 O15165 LRAD4_HUMAN Low-density lipoprotein receptor class A domain-containing protein 4 LDLRAD4 C18orf1 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] R-SMAD binding [GO:0070412] DPEQQMELNR;LGASEIMHAPR 2 6.9 0.95538 -0.86013 0 0 6.45022 0 0 0 0 0 0 0 0 0 O15169 AXIN1_HUMAN Axin-1 (Axis inhibition protein 1) (hAxin) AXIN1 AXIN Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axial mesoderm formation [GO:0048320]; beta-catenin destruction complex assembly [GO:1904885]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral axis specification [GO:0009950]; epigenetic programming in the zygotic pronuclei [GO:0044725]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; nucleocytoplasmic transport [GO:0006913]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-anal tail morphogenesis [GO:0036342]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein-containing complex assembly [GO:0065003]; sensory perception of sound [GO:0007605] beta-catenin destruction complex [GO:0030877]; cell cortex [GO:0005938]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]; R-SMAD binding [GO:0070412]; signaling adaptor activity [GO:0035591]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AVTLGQFKELLTKK;CDQDMDEDDGR;EDEAVLPVFEEKIIGK;GETSTATPRR;LLLETAAPRVSSSRR;VGVACKRNAK;VPLPHIPRTYRVPK 7 10.4 0.98092 -2.0243 2.13146 0 7.30287 7.94275 9.38323 9.92413 7.05235 0 0 0 0 0 O15173 PGRC2_HUMAN Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) PGRMC2 DG6 PMBP Homo sapiens (Human) adipose tissue development [GO:0060612] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496] ILLAVNGKVFDVTK 1 6.3 0.9227 -0.4424 0 0 0 0 0 0 0 0 0 0 9.34465 0 O15195 VILL_HUMAN Villin-like protein VILL Homo sapiens (Human) actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; structural constituent of cytoskeleton [GO:0005200]" VEVWCIQDLHRQPVDPK 1 2 0.91781 -0.43503 11.2425 0 0 0 0 0 0 0 0 0 0 0 O15197 EPHB6_HUMAN Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) EPHB6 Homo sapiens (Human) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; signaling receptor activity [GO:0038023]; transmembrane-ephrin receptor activity [GO:0005005] DSYPHNNFPFAL 1 2.2 0.80635 0.012184 0 0 6.79818 0 0 0 0 0 0 0 0 0 O15205 UBD_HUMAN Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10) UBD FAT10 Homo sapiens (Human) aggresome assembly [GO:0070842]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein modification by small protein conjugation [GO:0032446]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] proteasome binding [GO:0070628] TKVPVQDQVLLLGSKILKPR 1 12.1 0.85153 -0.079704 0 0 0 0 0 0 0 0 0 0 0 5.03936 O15211 RGL2_HUMAN Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) RGL2 RAB2L Homo sapiens (Human) negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] KEFAVLSELRR;LPRPLRLLLDTSPPGGVVLSSFRSR 2 4.6 0.9677 -1.3192 0 0 0 0 0 9.44381 0 0 5.61147 0 0 0 O15212 PFD6_HUMAN Prefoldin subunit 6 (Protein Ke2) PFDN6 HKE2 PFD6 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] AGAPGKA 1 5.4 0.40406 0.20731 0 0 11.3397 0 0 0 0 0 13.0968 9.08783 11.99 0 O15213 WDR46_HUMAN WD repeat-containing protein 46 (WD repeat-containing protein BING4) WDR46 BING4 C6orf11 FP221 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] EQIERLGYDPQAK;ILCHRGGVR;ISKKPQVPKKPR;KLMCEINVMEAVR;LGYDPQAK;SRLEVAEAEEEETSIK;VRQSLQQQHHKEAK;WLHIYDNQGIELHCIR 8 15.2 0.97518 -3.4483 13.0939 0 10.7981 0 0 0 6.68047 9.05145 9.68767 10.2743 9.11314 0 O15226 NKRF_HUMAN NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) NKRF ITBA4 NRF Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVNEQTHFASMPR;MGFMLPLIFRYSPRLMEK 2 4.4 0.74957 0.078505 0 6.84662 0 0 0 0 0 0 0 0 0 8.3512 O15228 GNPAT_HUMAN Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DAPAT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) GNPAT DAPAT DHAPAT Homo sapiens (Human) cerebellum morphogenesis [GO:0021587]; ether lipid biosynthetic process [GO:0008611]; membrane organization [GO:0061024]; paranodal junction assembly [GO:0030913]; phosphatidic acid biosynthetic process [GO:0006654]; response to fatty acid [GO:0070542]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] glycerone-phosphate O-acyltransferase activity [GO:0016287] KINNNCIFNVNEPATTK;YLLSEEEDHFSEEQYLAAVR 2 5.4 0.71298 0.14683 0 8.44406 0 9.83408 0 0 0 0 0 0 0 0 O15229 KMO_HUMAN Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) KMO Homo sapiens (Human) "'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; kynurenic acid biosynthetic process [GO:0034276]; kynurenine metabolic process [GO:0070189]; L-kynurenine metabolic process [GO:0097052]; NAD metabolic process [GO:0019674]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; quinolinate biosynthetic process [GO:0019805]; response to salt stress [GO:0009651]; tryptophan catabolic process [GO:0006569]" cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; kynurenine 3-monooxygenase activity [GO:0004502]; NAD(P)H oxidase H2O2-forming activity [GO:0016174] DLLTAAEK;DLLTAAEKYPNVKMHFNHR;GRQALKAVGLEDQIVSQGIPMR;LLTSNDVVDFFQK 4 11.1 0.95231 -0.74237 0 14.1451 8.42471 0 0 10.2471 0 0 0 12.9265 0 0 O15230 LAMA5_HUMAN Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) LAMA5 KIAA0533 KIAA1907 Homo sapiens (Human) branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; hair follicle development [GO:0001942]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; muscle organ development [GO:0007517]; odontogenesis of dentin-containing tooth [GO:0042475]; postsynapse organization [GO:0099173]; protein localization to plasma membrane [GO:0072659]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of epithelial cell proliferation [GO:0050678]; skeletal system morphogenesis [GO:0048705]; substrate adhesion-dependent cell spreading [GO:0034446]; trunk neural crest cell migration [GO:0036484] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; laminin-5 complex [GO:0005610]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; synaptic cleft [GO:0043083] cell adhesion mediator activity [GO:0098631]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018] CVCHGHADACDAK;ILLVTDGAR;KDPRVGR;MQTFSPAGSK;QMIQETK;QVVPHERQPGTEMLR;TLAEVERLLWEMR;VGFEGATCDR 8 2.3 0.97466 -3.9121 4.36233 13.873 0 0 7.91271 0 11.8079 0 0 0 0 0 O15231 ZN185_HUMAN Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) ZNF185 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] zinc ion binding [GO:0008270] LAPYNIRR;LVAPDVEGMR 2 2.6 0.95482 -0.82384 0 14.0624 0 0 0 0 0 0 9.43559 0 0 0 O15232 MATN3_HUMAN Matrilin-3 MATN3 Homo sapiens (Human) cartilage development [GO:0051216]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] GPGGSPGRRPSPAAPDGAPASGTSEPGR 1 5.8 0.94275 -0.62201 0 0 0 0 0 11.3647 0 0 0 0 0 0 O15234 CASC3_HUMAN Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) CASC3 MLN51 Homo sapiens (Human) "intracellular mRNA localization [GO:0008298]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]" cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; U2-type catalytic step 1 spliceosome [GO:0071006] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] GEEKPDTK;KPRYGSPPQRDPNWNGER;QELIALYGYDIR;TFINRNAAGTGR;VESGGAK 5 8.1 0.97961 -2.0432 0 0 10.5885 0 0 8.59809 11.4466 8.05241 0 0 0 0 O15235 RT12_HUMAN "Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt) (MT-RPS12)" MRPS12 RPMS12 RPSM12 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LGPPKRPPR 1 6.5 0.90123 -0.26392 0 0 0 0 0 0 0 6.43545 0 0 0 0 O15240 VGF_HUMAN Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] VGF Homo sapiens (Human) carbohydrate homeostasis [GO:0033500]; defense response to bacterium [GO:0042742]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ovarian follicle development [GO:0001541]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to cAMP [GO:0051591]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; sexual reproduction [GO:0019953]; synaptic signaling via neuropeptide [GO:0099538] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184] ASWGEFQAR;LADLASDLLLQYLLQGGARQR;RLQEQEELENYIEHVLLR 3 7.8 0.95506 -0.95002 0 7.90057 11.6364 0 0 0 0 0 0 0 0 0 O15244 S22A2_HUMAN Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) SLC22A2 OCT2 Homo sapiens (Human) acetylcholine transport [GO:0015870]; amine transport [GO:0015837]; amino acid import across plasma membrane [GO:0089718]; body fluid secretion [GO:0007589]; cellular detoxification [GO:1990748]; choline transport [GO:0015871]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; export across plasma membrane [GO:0140115]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; monoatomic cation transport [GO:0006812]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] acetylcholine transmembrane transporter activity [GO:0005277]; amine transmembrane transporter activity [GO:0005275]; choline transmembrane transporter activity [GO:0015220]; efflux transmembrane transporter activity [GO:0015562]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910] WLISQNKNAEAMRIIK 1 2.9 0.96149 -1.0648 0 0 0 0 0 0 0 0 0 0 9.14011 0 O15245 S22A1_HUMAN Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) SLC22A1 OCT1 Homo sapiens (Human) acetylcholine transport [GO:0015870]; acyl carnitine transmembrane transport [GO:1902616]; cellular detoxification [GO:1990748]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; metanephric proximal tubule development [GO:0072237]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; quaternary ammonium group transport [GO:0015697]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] (R)-carnitine transmembrane transporter activity [GO:1901235]; acetylcholine transmembrane transporter activity [GO:0005277]; dopamine:sodium symporter activity [GO:0005330]; identical protein binding [GO:0042802]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910] GVALPETMK 1 1.6 0.90554 -0.27101 0 0 0 0 0 0 0 0 0 10.4385 0 0 O15247 CLIC2_HUMAN Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) CLIC2 Homo sapiens (Human) chloride transport [GO:0006821]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of binding [GO:0051099]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602] EANKNFEK;YLHNAYAREEFTHTCPEDK 2 10.9 0.97849 -1.5301 0 0 9.50756 0 0 0 0 0 0 0 0 0 O15254 ACOX3_HUMAN Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) ACOX3 BRCOX PRCOX Homo sapiens (Human) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; pristanoyl-CoA oxidase activity [GO:0016402] CKRIFEYDFLSVEDMFK;ELNFLRCKR;FWVGNMGK 3 4.4 0.91673 -0.34171 11.4072 0 0 7.77492 0 0 0 8.6467 0 0 0 0 O15255 CXX1_HUMAN CAAX box protein 1 (Cerebral protein 5) RTL8C CXX1 FAM127A MAR8 MAR8C MART8 hucep-5 Homo sapiens (Human) plasma membrane [GO:0005886] LPDDYIILPTDLR;LPDDYIILPTDLRCHSHR 2 8.6 0.96341 -1.0876 0 0 10.2674 0 0 0 0 0 10.153 0 0 0 O15258 RER1_HUMAN Protein RER1 RER1 Homo sapiens (Human) "positive regulation of protein localization to plasma membrane [GO:1903078]; protein retention in ER lumen [GO:0006621]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]" cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] acetylcholine receptor binding [GO:0033130] SEGDSVGESVHGKPSVVYR 1 9.7 0.78189 0.022635 0 0 0 0 6.04638 0 0 0 0 0 0 0 O15259 NPHP1_HUMAN Nephrocystin-1 (Juvenile nephronophthisis 1 protein) NPHP1 NPH1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization involved in establishment of planar polarity [GO:0090251]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; spermatid differentiation [GO:0048515]; visual behavior [GO:0007632] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391] structural molecule activity [GO:0005198] EALEPNK;EENESHK;GEILLVIEK;ILPCLLDGDCFIR 4 4.9 0.9658 -1.2393 7.45409 7.02746 0 0 5.26236 5.93492 0 0 0 11.7926 0 0 O15260 SURF4_HUMAN Surfeit locus protein 4 SURF4 SURF-4 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; positive regulation of organelle organization [GO:0010638]; regulation of lipid transport [GO:0032368] azurophil granule membrane [GO:0035577]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] cargo receptor activity [GO:0038024]; COPII receptor activity [GO:0097020] SMFAGVPTMR 1 3.7 0.008658 1.0416 0 0 0 0 0 0 0 0 0 0 9.70537 0 O15264 MK13_HUMAN Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) MAPK13 PRKM13 SAPK4 Homo sapiens (Human) cellular response to anisomycin [GO:0072740]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to sodium arsenite [GO:1903936]; cellular response to sorbitol [GO:0072709]; cellular response to UV [GO:0034644]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; response to osmotic stress [GO:0006970]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ASPQAADLLEK 1 3 0.89807 -0.23168 0 0 0 0 9.16048 0 0 0 0 0 0 0 O15265 ATX7_HUMAN Ataxin-7 (Spinocerebellar ataxia type 7 protein) ATXN7 SCA7 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; nucleus organization [GO:0006997]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] QIGRGYYVFDSRWNR;VEKIHPK 2 2.5 0.95409 -0.95305 0 9.39936 0 0 6.0545 0 0 0 0 0 0 0 O15266 SHOX_HUMAN Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) SHOX PHOG Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DHVDNDKEK;EDVKSEDEDGQTK;EFGTARVAEGIYECKEK;VAEGIYECK 4 13.4 0.96284 -1.1026 0 5.76325 15.0757 0 8.24332 6.57601 0 0 0 0 0 0 O15269 SPTC1_HUMAN Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) SPTLC1 LCB1 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; regulation of fat cell apoptotic process [GO:1904649]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] GFYGTFDVHLDLEDR 1 3.2 0.26667 0.26635 0 8.64028 0 0 0 0 0 0 0 0 0 0 O15270 SPTC2_HUMAN Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) SPTLC2 KIAA0526 LCB2 Homo sapiens (Human) adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] IEKCHHATEREEQK;IGAFGREMLK;MRPEPGGCCCRR 3 6.4 0.9746 -2.386 0 0 0 0 0 0 0 0 0 5.42314 8.23012 0 O15273 TELT_HUMAN Telethonin (Titin cap protein) TCAP Homo sapiens (Human) adult heart development [GO:0007512]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of mechanical stimulus [GO:0050982]; detection of muscle stretch [GO:0035995]; otic vesicle formation [GO:0030916]; protein-containing complex assembly [GO:0065003]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle contraction [GO:0003009]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756] cytosol [GO:0005829]; I band [GO:0031674]; Z disc [GO:0030018] BMP binding [GO:0036122]; FATZ binding [GO:0051373]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325] QEVAEITKQLPPVVPVSKPGALRR 1 14.4 0.62508 0.1736 0 0 8.72836 0 0 0 0 0 8.4607 0 7.08343 0 O15287 FANCG_HUMAN Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) FANCG XRCC9 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; mitochondrion organization [GO:0007005]; ovarian follicle development [GO:0001541]; response to radiation [GO:0009314]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] damaged DNA binding [GO:0003684] TSSLLPKMSRLWEDAR 1 2.6 0.97522 -1.4545 0 0 0 0 0 0 0 0 10.6475 0 0 0 O15294 OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) OGT Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; hemopoiesis [GO:0030097]; mitophagy [GO:0000423]; negative regulation of cell migration [GO:0030336]; negative regulation of non-canonical inflammasome complex assembly [GO:0160076]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of proteolysis [GO:0045862]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; positive regulation of translation [GO:0045727]; protein O-linked glycosylation [GO:0006493]; protein processing [GO:0016485]; regulation of gluconeogenesis [GO:0006111]; regulation of glycolytic process [GO:0006110]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of necroptotic process [GO:0060544]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; signal transduction [GO:0007165] cell projection [GO:0042995]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; histone acetyltransferase complex [GO:0000123]; mitochondrial membrane [GO:0031966]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein N-acetylglucosaminyltransferase complex [GO:0017122]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822] "acetylglucosaminyltransferase activity [GO:0008375]; chromatin DNA binding [GO:0031490]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein O-acetylglucosaminyltransferase activity [GO:0097363]; RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity [GO:0140842]; RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity [GO:0140843]" ISSPLFNTKQYTMELER;LGTDLEYLKKVR;LPSVHPHHSMLYPLSHGFR;REQGNIEEAVRLYR 4 5.9 0.96477 -1.1549 0 6.67129 10.1264 0 0 0 9.49721 0 0 0 8.33602 0 O15296 LX15B_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-) ALOX15B Homo sapiens (Human) apoptotic process [GO:0006915]; arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; endocannabinoid signaling pathway [GO:0071926]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; phospholipid metabolic process [GO:0006644]; positive regulation of chemokine production [GO:0032722]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostate gland development [GO:0030850]; regulation of epithelial cell differentiation [GO:0030856] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] arachidonate 15-lipoxygenase activity [GO:0050473]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; linoleate 9S-lipoxygenase activity [GO:1990136]; lipid binding [GO:0008289] GLWRSLNEMK;TVEDLELNIK 2 3 0.95302 -0.73678 0 0 9.1702 0 0 0 0 0 0 0 0 0 O15297 PPM1D_HUMAN Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) PPM1D WIP1 Homo sapiens (Human) "cellular response to starvation [GO:0009267]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of intracellular signal transduction [GO:1902531]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; response to bacterium [GO:0009617]; response to radiation [GO:0009314]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AVEVTQDHKPELPKERER;DDFVRAVEVTQDHKPELPK;SLEEDPWPR 3 5.3 0.95328 -0.77714 0 0 0 7.72281 0 0 0 0 0 0 0 8.16892 O15303 GRM6_HUMAN Metabotropic glutamate receptor 6 (mGluR6) GRM6 GPRC1F MGLUR6 Homo sapiens (Human) "chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; detection of visible light [GO:0009584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of synaptic transmission, glutamatergic [GO:0051966]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]" dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886]; synapse [GO:0045202] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; protein homodimerization activity [GO:0042803] IGRDSTYEQEGK;IYRIFEQGK;LFLGLGTTLSYSALLTKTNR;LTSSGTQSDDSTRK;MVKGVPCCWHCEACDGYR 5 8.3 0.97182 -2.7036 6.12489 0 9.91096 0 0 3.75061 0 9.82677 10.3442 0 0 0 O15304 SIVA_HUMAN Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) SIVA1 SIVA Homo sapiens (Human) activation-induced cell death of T cells [GO:0006924]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] CD27 receptor binding [GO:0005175]; metal ion binding [GO:0046872]; tumor necrosis factor receptor binding [GO:0005164]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] ELSRGVCAERYSQEVFEK;GVCAERYSQEVFEK 2 10.3 0.7061 0.15952 0 0 0 0 0 0 0 7.1815 8.41028 0 0 0 O15305 PMM2_HUMAN Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) PMM2 Homo sapiens (Human) GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose biosynthetic process from fructose-6-phosphate [GO:0061729]; GDP-mannose biosynthetic process from glucose [GO:0141199]; GDP-mannose biosynthetic process from mannose [GO:0061728]; mannose catabolic process [GO:0019309]; mannose metabolic process [GO:0006013]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615] IEFYELDK;IGVVGGSDFEK;VQEQLGNDVVEK 3 12.6 0.9646 -1.2244 11.5116 0 0 0 0 0 0 0 0 0 11.5216 0 O15318 RPC7_HUMAN DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32) POLR3G Homo sapiens (Human) cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] chromatin binding [GO:0003682]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] KMEELEK;QDIERYSKR;RMPYFIETPEERQDIER 3 12.6 0.88085 -0.16856 0 0 0 0 0 0 10.5433 0 0 10.355 0 10.9076 O15321 TM9S1_HUMAN Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70) TM9SF1 Homo sapiens (Human) autophagy [GO:0006914]; protein localization to membrane [GO:0072657] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] AGDPVILYVNK 1 1.8 0.74034 0.10566 0 0 11.1231 0 0 0 0 0 0 0 0 0 O15327 INP4B_HUMAN "Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)" INPP4B Homo sapiens (Human) inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] "inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]" ALDCMRR;ALLENLLQNIQSKKR;DKSHDTVRTSVLPEHK;DQLVRSALLALYTARPGGILKKPPSPK;LPARMFESLPLQIK;LTVYDVK;NPVCKLYR;SALLALYTARPGGILKKPPSPK;VGELLKSKEQLLVLSLR 9 12 0.96064 -1.0566 0 14.318 0 7.48156 10.8066 0 0 5.26104 0 10.8117 0 10.6383 O15335 CHAD_HUMAN Chondroadherin (Cartilage leucine-rich protein) CHAD SLRR4A Homo sapiens (Human) bone development [GO:0060348]; negative regulation of bone trabecula formation [GO:1900155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] VTELPRGLLSPLVNLFILQLNNNKIR 1 7.2 0.68336 0.16504 0 0 0 0 0 0 0 0 0 5.43189 0 0 O15344 TRI18_HUMAN E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) MID1 FXY RNF59 TRIM18 XPRF Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; pattern specification process [GO:0007389]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372]; regulation of microtubule cytoskeleton organization [GO:0070507] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] AINQAGSR;LDPKSAHR;QCIERSASLISQAEHSLK 3 5.1 0.98094 -1.7313 9.4624 0 0 0 0 0 9.8479 0 0 0 0 0 O15347 HMGB3_HUMAN High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) HMGB3 HMG2A HMG4 Homo sapiens (Human) DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]" KKVEEEDEEEEEEEEEEEEEEDE;NPEVPVNFAEFSK;STNPGISIGDVAK 3 24.5 0.84632 -0.060755 0 0 8.32211 1.07519 0 0 0 0 0 10.3179 8.45873 0 O15350 P73_HUMAN Tumor protein p73 (p53-like transcription factor) (p53-related protein) TP73 P73 Homo sapiens (Human) DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; kidney development [GO:0001822]; mismatch repair [GO:0006298]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410] cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]" DAQQPWPR 1 1.9 0.91407 -0.39033 0 0 0 0 0 0 0 0 0 0 9.05227 0 O15353 FOXN1_HUMAN Forkhead box protein N1 (Winged-helix transcription factor nude) FOXN1 RONU WHN Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; blood vessel morphogenesis [GO:0048514]; defense response [GO:0006952]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; keratinocyte differentiation [GO:0030216]; lymphoid lineage cell migration into thymus [GO:0097535]; nail development [GO:0035878]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of hair follicle development [GO:0051798]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell homeostasis [GO:0043029]; T cell lineage commitment [GO:0002360]; thymus epithelium morphogenesis [GO:0097536] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]" QGDLMQAPGLPGSPAPQSK 1 2.9 0.85068 -0.075108 10.5275 0 0 0 0 0 0 0 0 0 0 0 O15354 GPR37_HUMAN Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR) GPR37 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to reactive oxygen species [GO:0034614]; dendrite development [GO:0016358]; dopamine biosynthetic process [GO:0042416]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuropeptide signaling pathway [GO:0007218]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of MAPK cascade [GO:0043410] cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]; ubiquitin protein ligase binding [GO:0031625] AFMECCCCCCEECIQK;APGALLARMSRLLLLLLLK;DAWGPGNSARDVLRAR;LAVIWVGALLLALPEVVLRQLSK;TVPGASDLFYWPR 5 14.2 0.95261 -0.68182 0 0 10.0933 4.47457 5.81716 5.72022 0 6.38486 0 7.54466 5.75082 10.1084 O15355 PPM1G_HUMAN Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) PPM1G PPM1C Homo sapiens (Human) peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] QLIVANAGDSR;VNGGLNLSR 2 3.7 0.95279 -0.75238 0 0 0 0 0 0 0 0 0 11.3922 10.9019 0 O15357 SHIP2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" INPPL1 SHIP2 Homo sapiens (Human) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; endochondral ossification [GO:0001958]; endocytosis [GO:0006897]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; post-embryonic development [GO:0009791]; regulation of actin filament organization [GO:0110053]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; response to insulin [GO:0032868]; ruffle assembly [GO:0097178] basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922] "actin binding [GO:0003779]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]" DSQEDWTTFTHDR;QLPTLKPILADIEYLQDQHLLLTVK 2 3 0.68538 0.16306 0 0 0 0 0 3.64766 7.12267 0 0 0 0 0 O15360 FANCA_HUMAN Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) DNA repair [GO:0006281]; female gonad development [GO:0008585]; interstrand cross-link repair [GO:0036297]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; protein-containing complex assembly [GO:0065003]; regulation of CD40 signaling pathway [GO:2000348]; regulation of germ cell proliferation [GO:1905936]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GQGNPVELITK;GQGNPVELITKARLFLLQLIPR 2 1.5 0.94221 -0.59519 0 0 0 0 0 0 0 0 0 0 6.23091 10.7864 O15371 EIF3D_HUMAN Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66) EIF3D EIF3S7 Homo sapiens (Human) cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]" mRNA cap binding [GO:0098808]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] AFDRITTR;GAVIATELK 2 3.1 0.98054 -1.6482 0 11.8824 0 0 0 0 0 0 0 0 0 0 O15372 EIF3H_HUMAN Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) EIF3H EIF3S3 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; membrane [GO:0016020]" metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] EFTAQNLGK 1 2.6 0.92892 -0.48313 0 0 0 0 0 0 0 0 0 0 0 11.2224 O15374 MOT5_HUMAN Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4) SLC16A4 MCT4 MCT5 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; monocarboxylic acid transport [GO:0015718] membrane [GO:0016020]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] LALSTAIARSGMGLTFLLAPFTK 1 4.7 0.83408 -0.029624 0 0 0 0 0 0 0 0 0 0 0 7.05788 O15379 HDAC3_HUMAN Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) HDAC3 Homo sapiens (Human) cellular response to fluid shear stress [GO:0071498]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; cornified envelope assembly [GO:1903575]; DNA repair-dependent chromatin remodeling [GO:0140861]; epigenetic regulation of gene expression [GO:0040029]; establishment of mitotic spindle orientation [GO:0000132]; establishment of skin barrier [GO:0061436]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural precursor cell proliferation [GO:0061351]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; random inactivation of X chromosome [GO:0060816]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle [GO:0007346]; regulation of multicellular organism growth [GO:0040014]; regulation of protein stability [GO:0031647]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; NF-kappaB binding [GO:0051059]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein decrotonylase activity [GO:0160008]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]" KMIVFKPYQASQHDMCR;VLYIDIDIHHGDGVQEAFYLTDR 2 9.3 0.44225 0.19357 6.83769 9.02428 0 0 0 0 0 0 0 0 0 0 O15381 NVL_HUMAN Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) NVL NVL2 Homo sapiens (Human) positive regulation of protein binding [GO:0032092]; positive regulation of telomere maintenance [GO:0032206]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; telomerase holoenzyme complex assembly [GO:1905323] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; RNA binding [GO:0003723] QKSGNEKGELK 1 1.3 0.86531 -0.089266 0 0 0 0 0 0 0 0 7.07874 0 0 0 O15382 BCAT2_HUMAN "Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18)" BCAT2 BCATM BCT2 ECA40 Homo sapiens (Human) branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to leukemia inhibitory factor [GO:1990830]; isoleucine catabolic process [GO:0006550]; L-leucine biosynthetic process [GO:0009098]; L-valine biosynthetic process [GO:0009099]; lipid metabolic process [GO:0006629]; regulation of hormone levels [GO:0010817] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine-2-oxoglutarate transaminase activity [GO:0052656]; L-leucine-2-oxoglutarate transaminase activity [GO:0052654]; L-valine-2-oxoglutarate transaminase activity [GO:0052655] FQKELKEIQYGIR;LELLECIR 2 5.4 0.91684 -0.42541 0 0 12.3351 0 0 0 0 12.0386 0 0 0 9.711 O15391 TYY2_HUMAN Transcription factor YY2 (Yin and yang 2) (YY-2) (Zinc finger protein 631) YY2 ZNF631 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AFLESSK;FSLDFNLR;VHVCAECGKAFLESSK 3 6.5 0.96493 -1.1418 4.91614 0 0 0 0 0 0 9.66837 0 0 9.57298 0 O15393 TMPS2_HUMAN Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain] TMPRSS2 PRSS10 Homo sapiens (Human) positive regulation of viral entry into host cell [GO:0046598]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; viral translation [GO:0019081] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GKTSEVLNAAK;LYHSDACSSK;VLLIETQR 3 5.9 0.95282 -0.76548 0 0 0 0 0 7.31868 0 0 0 0 0 5.87929 O15394 NCAM2_HUMAN Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) axonal fasciculation [GO:0007413]; neuron cell-cell adhesion [GO:0007158] axon [GO:0030424]; membrane [GO:0016020]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060] identical protein binding [GO:0042802] EVASEIWK;KSGSSGK;VELSVGESK 3 2.9 0.92064 -0.43751 0 13.4017 0 0 0 0 0 0 0 9.45865 0 0 O15397 IPO8_HUMAN Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) IPO8 RANBP8 Homo sapiens (Human) protein import into nucleus [GO:0006606]; signal transduction [GO:0007165] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] small GTPase binding [GO:0031267] QLVNREDR 1 0.8 0.98 -1.5683 0 0 0 0 0 0 0 10.2976 0 0 0 0 O15399 NMDE4_HUMAN "Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)" GRIN2D GluN2D NMDAR2D Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; cellular response to L-glutamate [GO:1905232]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787] glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; voltage-gated monoatomic cation channel activity [GO:0022843] RAAGGWDLPPPAPTSR;RGAGGPR;TPAAAAPHHHRHR;VEEALTQLKAGK;YFMNITWDNR 5 4.3 0.97517 -3.9801 0 0 0 0 0 10.7266 0 0 0 10.0456 9.97542 0 O15400 STX7_HUMAN Syntaxin-7 STX7 Homo sapiens (Human) intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] ISSNIQK;TLCIIILILVIGVAIISLIIWGLNH;TLNQLGTPQDSPELRQQLQQK 3 20.3 0.95625 -0.99582 0 0 13.1704 0 0 0 3.22129 0 0 0 11.6309 0 O15403 MOT7_HUMAN Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) SLC16A6 MCT6 MCT7 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; monocarboxylic acid transport [GO:0015718] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine transmembrane transporter activity [GO:0005368] KAPLLDFSILKEK 1 2.5 0.96327 -1.0904 0 0 0 0 0 0 12.4774 0 0 0 0 0 O15409 FOXP2_HUMAN Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) FOXP2 CAGH44 TNRC10 Homo sapiens (Human) caudate nucleus development [GO:0021757]; cerebral cortex development [GO:0021987]; negative regulation of DNA-templated transcription [GO:0045892]; putamen development [GO:0021758]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" RHSDKYNIPMSSEIAPNYEFYK 1 3.1 0.55985 0.18276 0 0 0 0 0 0 0 0 0 8.03144 0 0 O15417 TNC18_HUMAN Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) TNRC18 CAGL79 KIAA1856 Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] DARARER;DSEDRREEPHR;GPGRPRK;IAAYWSQQYR;LDRDQEK;LPSVENRPK;LSPFLAESK;LTPSLLCSMVAK;RQRLPSVENRPK 9 2.5 0.97613 -5.2425 14.4759 8.58177 9.96453 7.12081 0 0 13.2876 10.2361 13.2635 11.5053 8.07708 6.54029 O15417 TNC18_HUMAN Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) TNRC18 CAGL79 KIAA1856 Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] DARARER;DSEDRREEPHR;GPGRPRK;LDRDQEK;LLRSPHSLCSPRLRPGPR;LSPFLAESK;LTPSLLCSMVAK 7 3.1 0.50741 0.1878 0 0 0 0 0 0 0 0 0 0 4.48349 0 O15417 TNC18_HUMAN Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) TNRC18 CAGL79 KIAA1856 Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] VGLQPGVSVKGTRWR 1 4.8 0.75668 0.074276 0 0 0 0 0 15.1959 0 15.8481 0 15.0074 14.8106 14.7009 O15427 MOT4_HUMAN Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) SLC16A3 MCT3 MCT4 Homo sapiens (Human) lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] lactate:proton symporter activity [GO:0015650]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; RNA binding [GO:0003723] DLGVPDTK;GGAVVDEGPTGVK 2 4.5 0.91621 -0.35094 0 0 0 0 0 0 0 9.01274 0 0 0 0 O15438 MRP3_HUMAN ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) ABCC3 CMOAT2 MLP2 MRP3 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910] GVVAEFDSPANLIAAR;LIQDLLSFINPQLLSILIR;LPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVER;MAIYGYRHPLEEK;RHLGPSEK;TGAGKSSMTLCLFR 6 7.1 0.9811 -1.7568 11.7015 0 12.0015 0 0 0 0 0 0 0 10.553 0 O15439 MRP4_HUMAN ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) ABCC4 MOATB MRP4 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; leukotriene transport [GO:0071716]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; prostaglandin transport [GO:0015732]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate transport [GO:0015747]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088] 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; guanine nucleotide transmembrane transporter activity [GO:0001409]; prostaglandin transmembrane transporter activity [GO:0015132]; purine nucleotide transmembrane transporter activity [GO:0015216]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910] AIIKCYWK;IIKMYAWEKSFSNLITNLR;LEEDDMYSVLPEDRSQHLGEELQGFWDK;MDTELAESGSNFSVGQR;QLPSDGKKMVHVQDFTAFWDK;VAMCHMIYR 6 7.7 0.95433 -0.91463 0 0 0 2.30641 0 0 7.83207 8.26562 7.76752 0 0 7.7866 O15440 MRP5_HUMAN ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) cAMP transport [GO:0070730]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; macromolecule transmembrane transporter activity [GO:0022884]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]; xenobiotic transmembrane transporter activity [GO:0042910] EAFADCTMLTIAHR;GANLSGGQRQR;KGELSMEDVWSLSK;SVRERTSTSGTHR;VSFTIKPK 5 4.2 0.97235 -2.6814 0 0 0 0 0 8.14817 0 9.6697 0 0 0 9.71426 O15444 CCL25_HUMAN C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine) CCL25 SCYA25 TECK Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of leukocyte tethering or rolling [GO:1903237]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; hormone activity [GO:0005179] EVQRAMK;IQEVSGSCNLPAAIFYLPK;LSSGNSK 3 22 0.91551 -0.37144 6.8157 0 7.30998 0 0 8.86731 11.7138 11.5967 0 0 0 0 O15455 TLR3_HUMAN Toll-like receptor 3 (CD antigen CD283) TLR3 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB phosphorylation [GO:0007252]; inflammatory response to wounding [GO:0090594]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to dsRNA [GO:0043331]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; type III interferon production [GO:0034343] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin-like protein ligase binding [GO:0044389] GLENIFEIYLSYNKYLQLTR;ISFYWNVSVHR;ISFYWNVSVHRVLGFKEIDR;SLNLQKNLITSVEKK 4 6.1 0.98023 -1.8152 0 0 8.5922 0 0 0 0 13.4105 0 0 10.6245 0 O15457 MSH4_HUMAN MutS protein homolog 4 (hMSH4) MSH4 Homo sapiens (Human) female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; mismatch repair [GO:0006298]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; nucleus [GO:0005634]; recombination nodule [GO:0005713]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983] ITNLIYLKHTLELVDPLK;LLSEIYEHIHCLYK;NPQIILSQFADNTTYAK 3 5.2 0.89555 -0.2276 0 0 0 6.43583 7.53224 0 0 8.86892 0 0 0 0 O15460 P4HA2_HUMAN "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4HA2 UNQ290/PRO330 Homo sapiens (Human) cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] EEDEWDSPHIVRYYDVMSDEEIERIK;LLSLDPSHER;QLDAGEEATTTKSQVLDYLSYAVFQLGDLHR 3 12.5 0.95485 -0.93766 0 0 0 0 0 0 0 6.95198 7.4446 0 0 0 O15466 SIA8E_HUMAN "Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV)" ST8SIA5 SIAT8E Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]" CCNAPAFLFTTQK;STLSRCCNAPAFLFTTQKNTPLGTK;VHTGTCSCC;YADPSANR 4 11.2 0.96512 -1.2557 11.3251 8.13299 0 0 7.30478 0 0 0 0 0 0 0 O15467 CCL16_HUMAN C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16) CCL16 ILINCK NCC4 SCYA16 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell communication [GO:0007154]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009] EVCTNPNDDWVQEYIK 1 13.3 0.78355 0.026871 0 0 0 0 8.60403 0 0 0 0 0 0 0 O15479 MAGB2_HUMAN Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) MAGEB2 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] APTTAAAAAAGVSSTK;EHFPEILK 2 7.5 0.020873 0.65154 11.4862 13.5412 0 11.4125 11.3798 11.2938 0 12.8608 12.8557 12.1616 0 12.5309 O15480 MAGB3_HUMAN Melanoma-associated antigen B3 (MAGE-B3 antigen) MAGEB3 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] ASSSSHA;TNMLVQFLMEMYKMKKPIMK 2 7.8 0.75193 0.080334 5.58138 0 0 8.13324 9.74734 0 10.6819 10.5281 0 0 8.29471 6.61126 O15484 CAN5_HUMAN Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) CAPN5 NCL3 Homo sapiens (Human) proteolysis [GO:0006508]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] DTFFQNPQYIFEVK;FSCVKPYEDQNYSALRRDCR;LPTVNNQLIYCHSNSR;NQLFERMLK 4 9.2 0.96306 -1.0992 0 0 0 0 0 0 6.45973 0 0 0 7.99633 0 O15488 GLYG2_HUMAN Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) GYG2 Homo sapiens (Human) glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] KLVVLITPQVSSLLR;KLVVLITPQVSSLLRVILSK 2 4 0.1009 0.36731 7.56056 0 0 0 6.62508 0 0 0 7.539 6.36634 0 5.74424 O15492 RGS16_HUMAN Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling) RGS16 RGSR Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] SATKLASR 1 4 0.97921 -1.5427 0 0 0 0 0 0 0 10.7321 0 0 0 0 O15498 YKT6_HUMAN Synaptobrevin homolog YKT6 (EC 2.3.1.-) YKT6 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903]" apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] cadherin binding [GO:0045296]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; SNAP receptor activity [GO:0005484] EADPMTKVQAELDETK;IILARKQNSCCAIM;LYSLSVLYK;LYSLSVLYKGEAK 4 26.2 0.9747 -1.428 0 0 12.6396 0 9.89045 0 10.6002 0 0 0 0 0 O15503 INSI1_HUMAN Insulin-induced gene 1 protein (INSIG-1) INSIG1 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; cellular response to sterol [GO:0036315]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of cargo loading into COPII-coated vesicle [GO:1901303]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein exit from endoplasmic reticulum [GO:0070862]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937] oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311] LLQRSLVLFSVGVVLALVLNLLQIQR 1 9.4 0.84144 -0.043106 0 0 0 5.63558 0 0 0 0 0 0 0 0 O15504 NUP42_HUMAN Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) NUP42 CG1 NUPL2 Homo sapiens (Human) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723] AICQFFLQGR;STPWGGSRDQEKPYFSSFDSGASTNR;VALKCLWK 3 19.6 0.97729 -1.5229 0 0 0 6.89712 0 9.77033 0 0 0 0 0 0 O15516 CLOCK_HUMAN Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) CLOCK BHLHE8 KIAA0334 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; photoperiodism [GO:0009648]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein acetylation [GO:0006473]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; chromatoid body [GO:0033391]; chromosome [GO:0005694]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" CHEHLMQYGKGKSCYYR;NQLEFCCHMLRGTIDPK;SKNQLEFCCHMLR 3 4.3 0.9553 -0.9714 0 9.675 0 0 0 0 0 0 0 0 0 0 O15519 CFLAR_HUMAN CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] CFLAR CASH CASP8AP1 CLARP MRIT Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of myoblast fusion [GO:1901740]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron differentiation [GO:0030182]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of necroptotic process [GO:0060544]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle tissue development [GO:0007519]; skeletal muscle tissue regeneration [GO:0043403]; skeletal myofibril assembly [GO:0014866]; wound healing [GO:0042060] CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877] AEIGEDLDK;NIHRIDLKTK 2 5.5 0.97676 -2.1907 0 0 0 0 0 0 0 0 0 0 0 14.3182 O15523 DDX3Y_HUMAN "ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)" DDX3Y DBY Homo sapiens (Human) cell differentiation [GO:0030154]; gamete generation [GO:0007276]; negative regulation of gene expression [GO:0010629] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] DLMACAQTGSGK;EEALHQFRSGK;GLDISNVR;HAIPIIKGKR;IGLDFCK;IVEQDTMPPK;MLDMGFEPQIR;SPILVATAVAAR;VGSTSENITQK;YLVLDEADR 10 15.3 0.98074 -2.0346 7.97235 7.68117 7.47233 0 9.80707 0 7.19318 0 0 0 0 0 O15524 SOCS1_HUMAN Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3) SOCS1 SSI1 TIP3 Homo sapiens (Human) "cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to amino acid stimulus [GO:0071230]; cytokine-mediated signaling pathway [GO:0019221]; fat cell differentiation [GO:0045444]; intracellular signal transduction [GO:0035556]; macrophage differentiation [GO:0030225]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein ubiquitination [GO:0016567]; regulation of cytokine production [GO:0001817]; regulation of protein phosphorylation [GO:0001932]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] cytokine receptor binding [GO:0005126]; insulin-like growth factor receptor binding [GO:0005159]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] ESFDCLFELLEHYVAAPR 1 8.5 0.78241 0.022541 0 0 0 3.41278 0 0 0 0 0 0 0 0 O15527 OGG1_HUMAN N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] OGG1 MMH MUTM OGH1 Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; depurination [GO:0045007]; depyrimidination [GO:0045008]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via single-strand annealing [GO:1901291]; nucleotide-excision repair [GO:0006289]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; response to xenobiotic stimulus [GO:0009410]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; enzyme binding [GO:0019899]; microtubule binding [GO:0008017]; oxidized purine DNA binding [GO:0032357]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LCQAFGPR;QSVCTTR;YVSASAR 3 5.4 0.96681 -1.2937 7.07103 0 0 0 0 8.25828 0 0 0 0 0 10.5534 O15528 CP27B_HUMAN "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.15.18) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1)" CYP27B1 CYP1ALPHA CYP27B Homo sapiens (Human) bone mineralization [GO:0030282]; calcitriol biosynthetic process from calciol [GO:0036378]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; decidualization [GO:0046697]; G1 to G0 transition [GO:0070314]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of bone mineralization [GO:0030500]; response to estrogen [GO:0043627]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766] cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] calcidiol 1-monooxygenase activity [GO:0004498]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; secalciferol 1-monooxygenase activity [GO:0062185] DWDQMFAFAQR;LRSLLAPLLLRPQAAAR;YAGTLNNVVCDLVRRLR 3 8.9 0.57164 0.18151 0 8.86725 0 0 0 0 0 0 7.43588 0 0 0 O15530 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) PDPK1 PDK1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of protein kinase B activity [GO:0032148]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mast cell degranulation [GO:0043304]; T cell costimulation [GO:0031295]; type B pancreatic cell development [GO:0003323] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IQEVWRQRYQSHPDAAVQ;LEYDFPEKFFPK;LYFGLSYAK;VLSPESK 4 8.3 0.93703 -0.53978 0 0 0 0 5.44959 9.38373 0 0 11.9031 0 11.3794 0 O15533 TPSN_HUMAN Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) TAPBP NGS17 TAPA Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; MHC class Ib protein complex assembly [GO:0002398]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen stabilization [GO:0050823]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; regulation of protein complex stability [GO:0061635]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; Tapasin-ERp57 complex [GO:0061779] MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; molecular adaptor activity [GO:0060090]; peptide antigen binding [GO:0042605]; protein folding chaperone [GO:0044183]; TAP complex binding [GO:0062061]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; unfolded protein binding [GO:0051082] FVPLPASAK;GAPAPHCEMSR 2 4.5 0.93828 -0.57369 0 0 0 0 0 0 0 0 0 6.56733 0 0 O15534 PER1_HUMAN Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) PER1 KIAA0482 PER RIGUI Homo sapiens (Human) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural retina development [GO:0003407]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of circadian rhythm [GO:0042752]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of hair cycle [GO:0042634]; regulation of p38MAPK cascade [GO:1900744]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] GGPDRDPGPR;LEVLEEIWSVRAR;SVFCRIRGGPDR 3 3.5 0.98075 -1.7396 0 10.3205 0 0 0 0 0 0 0 0 7.42501 0 O15535 ZSC9_HUMAN Zinc finger and SCAN domain-containing protein 9 (Cell proliferation-inducing gene 12 protein) (PRD51) (Zinc finger protein 193) ZSCAN9 ZNF193 PIG12 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DEVTKTEDR 1 2 0.98043 -1.5552 0 0 8.54817 0 0 0 0 0 0 0 0 0 O15537 XLRS1_HUMAN Retinoschisin (X-linked juvenile retinoschisis protein) RS1 XLRS1 Homo sapiens (Human) cell adhesion [GO:0007155]; eye development [GO:0001654]; protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylserine binding [GO:0001786]; protein-containing complex binding [GO:0044877]" DQTGNNR;EIKVISGILTQGR;LIPLGWHVRIAIR 3 14.7 0.97833 -2.0994 12.0968 0 0 0 0 0 13.0125 0 13.2737 7.69467 0 0 O15539 RGS5_HUMAN Regulator of G-protein signaling 5 (RGS5) RGS5 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] CKGLAALPHSCLER;NLVEPSLSSFDMAQKR;SPAKMAEK;TSLDEALQWR 4 26.5 0.97787 -2.1334 16.0328 0 0 0 12.1069 7.15623 0 0 0 15.2393 15.2387 11.7971 O15541 R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) RNF113A RNF113 ZNF183 Homo sapiens (Human) "DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]; snoRNA splicing [GO:0034247]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VTHNPMIQK 1 2.6 0.84721 -0.066032 0 0 0 0 0 0 0 0 3.5846 0 0 0 O15551 CLD3_HUMAN Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1) CLDN3 C7orf1 CPETR2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell junction maintenance [GO:0034331]; epithelial cell morphogenesis [GO:0003382]; establishment of endothelial blood-brain barrier [GO:0014045]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of wound healing [GO:0090303]; regulation of cell morphogenesis [GO:0022604]; regulation of membrane permeability [GO:0090559]; regulation of transepithelial transport [GO:0150111]; response to ethanol [GO:0045471]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666] apical junction complex [GO:0043296]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; transmembrane signaling receptor activity [GO:0004888] ITIVAGVLFLLAALLTLVPVSWSANTIIR;KYTATKVVYSAPR;VVYSAPR 3 19.1 0.9652 -1.2191 0 0 0 6.7502 8.93239 0 9.53218 0 0 5.6744 0 0 O15552 FFAR2_HUMAN Free fatty acid receptor 2 (G-protein coupled receptor 43) FFAR2 FFA2 GPCR43 GPR43 Homo sapiens (Human) cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to fatty acid [GO:0071398]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; ligand-gated ion channel signaling pathway [GO:1990806]; lipid storage [GO:0019915]; mucosal immune response [GO:0002385]; negative regulation of insulin secretion [GO:0046676]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of acute inflammatory response to non-antigenic stimulus [GO:0002879]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-8 production [GO:0032757]; regulation of acute inflammatory response [GO:0002673]; regulation of peptide hormone secretion [GO:0090276] cell projection [GO:0042995]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289] GLQVLRNQGSSLLGRR;LELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQR;QPQPAPVHILLLSLTLADLLLLLLLPFK 3 24.2 0.37917 0.21708 8.07441 0 0 0 0 4.6307 0 0 0 0 3.72421 0 O15553 MEFV_HUMAN Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; pyroptosome complex assembly [GO:1904270]; pyroptotic inflammatory response [GO:0070269]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; response to type II interferon [GO:0034341] autophagosome [GO:0005776]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ALEGGQAEVR;SLEVTISTGEK 2 2.7 0.93712 -0.55492 0 0 0 0 0 0 0 0 11.1597 0 11.3159 0 O15554 KCNN4_HUMAN Intermediate conductance calcium-activated potassium channel protein 4 (SKCa 4) (SKCa4) (hSK4) (Gardos channel) (IKCa1) (hIK1) (KCa3.1) (Putative Gardos channel) (hKCa4) KCNN4 IK1 IKCA1 KCA4 SK4 Homo sapiens (Human) calcium ion transport [GO:0006816]; cell volume homeostasis [GO:0006884]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; immune system process [GO:0002376]; macropinocytosis [GO:0044351]; phospholipid translocation [GO:0045332]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell receptor signaling pathway [GO:0050862]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of calcium ion import across plasma membrane [GO:1905664]; saliva secretion [GO:0046541]; stabilization of membrane potential [GO:0030322] cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; intermediate conductance calcium-activated potassium channel activity [GO:0022894]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; small conductance calcium-activated potassium channel activity [GO:0016286] EQVNSMVDISK;FRHWFVAKLYMNTHPGR 2 6.6 0.88698 -0.1911 0 4.49352 0 0 0 0 0 0 0 0 0 12.2017 O43143 DHX15_HUMAN ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) DHX15 DBP1 DDX15 Homo sapiens (Human) "antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]" EAMNDPLLER;EVDDLGPEVGDIK;IFEPPPPK;IMDRFNLPRR;LDLGEDYPSGK 5 6.5 0.71408 0.1502 0 0 0 0 10.3618 0 0 0 12.6294 11.6417 0 0 O43147 SGSM2_HUMAN Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1) SGSM2 KIAA0397 RUTBC1 Homo sapiens (Human) late endosome to Golgi transport [GO:0034499]; positive regulation of GTPase activity [GO:0043547] cytoplasm [GO:0005737]; melanosome [GO:0042470] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] AASVDDDEEEEDK;EAHPATR;LAACARECVESLHQNSR;LLCESMKR;LLCESMKRQIVSR;TADHYWTDPSADELVQR;VQELQQQAEGR 7 7.4 0.96522 -1.1354 6.60017 0 0 0 0 0 11.6687 0 0 6.99628 0 7.283 O43148 MCES_HUMAN mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) RNMT KIAA0398 Homo sapiens (Human) 7-methylguanosine mRNA capping [GO:0006370]; cellular response to leukemia inhibitory factor [GO:1990830] fibrillar center [GO:0001650]; mRNA cap methyltransferase RNMT:RAMAC complex [GO:0160130]; mRNA capping enzyme complex [GO:0031533]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235] mRNA 5'-cap (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723] MSLEQAK;NSQVRLPLGTLSKSEWEATR 2 5.4 0.95311 -0.67765 0 0 0 0 0 0 0 0 0 0 6.36831 0 O43149 ZZEF1_HUMAN Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 KIAA0399 Homo sapiens (Human) calcium ion binding [GO:0005509]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] GALFRWLEER;HFTEKNRAVIVDVK;IWMLEMKQK;LKAIHLLLRIVR;RMNCNVCDDFDLCYGCYAAK;YLMVKFLCTRQESAER 6 2.7 0.9654 -1.2132 0 5.93782 0 0 9.48249 0 2.75185 0 11.3854 0 9.98413 0 O43150 ASAP2_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)" ASAP2 DDEF2 KIAA0400 Homo sapiens (Human) cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] EDSQIRQSTAYSLHQPQGNK;EIISEVQR;GDDNTGENNIVQELTKEIISEVQR 3 4.4 0.93767 -0.5681 0 0 4.17864 7.67786 0 0 12.3216 0 0 0 0 0 O43151 TET3_HUMAN Methylcytosine dioxygenase TET3 (EC 1.14.11.80) TET3 KIAA0401 Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]" chromosome [GO:0005694]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] AAPGIKPSVRKPIQIK;APLLHSVSR;AQTALQQHLHHK;EDNRCVGK;GAVKEEK;LENCGACTSCTNR;LGLGQQEAKLYGKK;QRQLEARK;VEPQNHFSSFK;WGGTVVAEPQQK 10 6.1 0.97493 -3.4532 0 13.7738 9.86907 0 0 0 9.09474 9.09608 0 7.74839 7.75989 0 O43155 FLRT2_HUMAN Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2) FLRT2 KIAA0405 UNQ232/PRO265 Homo sapiens (Human) axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; cell adhesion involved in heart morphogenesis [GO:0061343]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron migration [GO:2001222] cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein-macromolecule adaptor activity [GO:0030674] CDRNFVYCNER;EAISLKLLFLSK;STYRICLVPLDAFNYR 3 5.9 0.96902 -1.3308 0 6.23485 0 0 0 8.71589 0 0 0 0 0 2.29672 O43156 TTI1_HUMAN TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT Hsp90 cochaperone complex [GO:0110078] FSTLSLLLGYLKLLGPKINFVLNSVAHLQR;IVEERRWNSDDLNASPK;LELVELVEDLLLK 3 5.5 0.64117 0.17253 9.71831 0 0 8.06948 0 0 0 0 5.52604 7.84856 0 0 O43157 PLXB1_HUMAN Plexin-B1 (Semaphorin receptor SEP) PLXNB1 KIAA0407 PLXN5 SEP Homo sapiens (Human) cell migration [GO:0016477]; inhibitory synapse assembly [GO:1904862]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; semaphorin receptor activity [GO:0017154]; semaphorin receptor binding [GO:0030215]; transmembrane signaling receptor activity [GO:0004888] AKYTLNDNR;IFFPGHRESPLHRDLGVPESR;RPTVEQGLGQLSNLLNSK 3 2.2 0.97242 -2.6829 0 0 0 0 0 15.1284 0 8.97983 9.27408 0 0 0 O43159 RRP8_HUMAN Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) RRP8 KIAA0409 NML hucep-1 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; energy homeostasis [GO:0097009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; rDNA heterochromatin formation [GO:0000183]; regulation of G1 to G0 transition [GO:1903450]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364] chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553] methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] FQPPQVPDQAPAEAPTEK;QALVGSDSAEDEKRK 2 7.2 0.88128 -0.15947 0 0 0 0 9.3539 0 0 0 0 0 9.74672 0 O43164 PJA2_HUMAN E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) PJA2 KIAA0438 RNF131 Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; long-term memory [GO:0007616]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of macrophage activation [GO:0043030]; regulation of protein kinase A signaling [GO:0010738] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] metal ion binding [GO:0046872]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] SLGRAGDDYEVLELDDVPK 1 2.7 0.8124 -0.012678 0 0 0 0 0 0 0 0 0 0 7.9244 0 O43166 SI1L1_HUMAN Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) SIPA1L1 E6TP1 KIAA0440 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; ephrin receptor signaling pathway [GO:0048013]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of synaptic plasticity [GO:0048167] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096] DFLLAKVINAENAAHKSEK;LNAGKGDGK;LQEESQNASDK;LQFVSKGCESVEMTLR;NEIGGEGER;NNNKWQR;SIQNTLKNK;TESSLSLDIHSK;TLSDESIYNSQR 9 5.8 0.97615 -5.314 11.9831 11.9164 0 8.52019 5.52089 0 10.2768 10.8113 0 10.7546 5.74809 0 O43167 ZBT24_HUMAN Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) ZBTB24 KIAA0441 ZNF450 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ADCSVLQNWE;IWRSVKLK 2 5.4 0.97748 -1.4995 0 0 0 7.90563 0 0 0 0 0 0 0 0 O43172 PRP4_HUMAN U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) PRPF4 PRP4 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; spliceosomal snRNP complex [GO:0097525]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540] U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070] EIPETTR;EIPETTRTSQMQELHKSLR;LWIANYSLPRAMK 3 6.1 0.94467 -0.63246 0 0 10.2812 8.30259 0 0 0 5.8622 0 0 0 0 O43174 CP26A_HUMAN Cytochrome P450 26A1 (CYP26A1) (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) CYP26A1 CYP26 P450RAI1 Homo sapiens (Human) central nervous system development [GO:0007417]; kidney development [GO:0001822]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] "all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; all-trans retinoic acid 4-hydrolase activity [GO:0062182]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" KVIMRAFSR 1 1.8 0.97382 -1.4075 0 0 0 9.97571 0 0 0 0 0 0 0 0 O43175 SERA_HUMAN D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) PHGDH PGDH3 Homo sapiens (Human) brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566] cytosol [GO:0005829]; extracellular exosome [GO:0070062] electron transfer activity [GO:0009055]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617] AFANLRK;AGTGVDNVDLEAATR;DLPLLLFR;GGIVDEGALLR;GTIQVITQGTSLK;ILQDGGLQVVEK;QADVNLVNAK;TQTSDPAMLPTMIGLLAEAGVR;VLISDSLDPCCRK;VTADVINAAEK 10 22.9 0 41.928 14.7496 13.129 13.5333 11.6947 10.8946 11.7024 12.2283 12.792 12.7654 12.6732 12.775 0 O43181 NDUS4_HUMAN "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Homo sapiens (Human) "aerobic respiration [GO:0009060]; brain development [GO:0007420]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of protein phosphorylation [GO:0001932]; response to cAMP [GO:0051591]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] MAAVSMSVVLR 1 6.3 0.92763 -0.45737 0 0 0 0 0 0 0 0 0 0 0 8.38055 O43182 RHG06_HUMAN Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) ARHGAP6 RHOGAP6 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of phospholipase activity [GO:0010518]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; SH3 domain binding [GO:0017124] ESSPGPRLGK;FQSPPDSRGHPYVVWK;LSLNPIYR;LSLNPIYRQVPR;QKSSDKEFSVQSSAR;SLLAMQEDAAPGGSEK;VPGQFMLVGHLSSSK 7 8.6 0.97576 -4.2942 9.47733 0 0 0 10.0297 9.13445 12.2053 0 11.8825 0 0 0 O43184 ADA12_HUMAN Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) ADAM12 MLTN UNQ346/PRO545 Homo sapiens (Human) cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508] extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124] CGNRFVEEGEECDCGEPEECMNR;FVEEGEECDCGEPEECMNR;VLPPLHR 3 3.3 0.92954 -0.46808 0 0 5.12371 0 0 0 5.32607 0 0 6.87467 0 0 O43187 IRAK2_HUMAN Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) IRAK2 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling adaptor activity [GO:0035591] TGVENVMAK 1 1.4 0.93048 -0.48874 0 0 0 0 0 0 0 0 10.1051 0 0 0 O43189 PHF1_HUMAN PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) PHF1 PCL1 Homo sapiens (Human) "DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of gene expression, epigenetic [GO:0045814]" centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription corepressor binding [GO:0001222] CRHAYHQDCHVPR;LVSCEKCR;LVSCEKCRHAYHQDCHVPR 3 3.4 0.96408 -1.195 0 0 0 10.1422 0 0 0 0 7.44344 0 0 0 O43193 MTLR_HUMAN Motilin receptor (G-protein coupled receptor 38) MLNR GPR38 MTLR MTLR1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562] GPAASGR 1 1.7 0.65357 0.16995 0 0 0 8.86016 0 0 10.6862 0 0 0 0 0 O43194 GPR39_HUMAN G-protein coupled receptor 39 GPR39 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872] ITLILVYLIIFVMGLLGNSATIR;LIVVTLAVCWMPNQIR 2 8.6 0.87658 -0.1324 0 0 0 0 8.10852 0 0 0 0 0 0 10.3611 O43196 MSH5_HUMAN MutS protein homolog 5 (hMSH5) MSH5 Homo sapiens (Human) chiasma assembly [GO:0051026]; mismatch repair [GO:0006298] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983] LLGHIKNVPLILK;NQMENCQTLVDK;SGKPIKPVKDLLKK;SLPQSIQLFR;VLDEINPQSVVTSAK;VSDWQVLYK 6 8.8 0.9691 -1.3307 0 5.19058 0 0 0 0 9.1557 0 0 0 10.5128 7.39772 O43236 SEPT4_HUMAN Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) SEPTIN4 C17orf47 PNUTL2 SEP4 SEPT4 hucep-7 Homo sapiens (Human) apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; hematopoietic stem cell homeostasis [GO:0061484]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein ubiquitination [GO:0031398]; protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]; regulation of exocytosis [GO:0017157]; spermatid differentiation [GO:0048515] axon [GO:0030424]; cell division site [GO:0032153]; cytosol [GO:0005829]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; presynapse [GO:0098793]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] ITTTSEIRSPR 1 1.9 0.97561 -1.4722 0 0 0 0 0 0 0 0 9.12311 0 0 0 O43237 DC1L2_HUMAN "Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)" DYNC1LI2 DNCLI2 LIC2 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; centrosome localization [GO:0051642]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018] centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; kinetochore [GO:0000776]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802] APVGVEK;EEKNLDLLYKYIVHK;GLEYLYLSVHDEDRDDHTR;NILVFGEDGSGK;NLDLLYK 5 10.8 0.96466 -1.1533 0 0 0 0 0 10.9163 0 0 10.2317 8.37773 11.0095 0 O43242 PSMD3_HUMAN 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) PSMD3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" enzyme regulator activity [GO:0030234] DLESAEERR;EAQKISDDLMQK;EMAEDDDDSFP;ISDDLMQK;ISFCLDIHNMSVK;LQFRQPSLK;MLPSTSR;QTVHKLLIVVELLLGEIPDR;SVFPEQANNNEWAR;TGVRMISLSYSR;TMTNALRKAPQHTAVGFK 11 23.4 0.97585 -2.3348 11.9727 11.9105 0 5.54055 9.82442 9.53982 9.40403 10.3399 0 12.0085 11.787 11.3262 O43252 PAPS1_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] PAPSS1 ATPSK1 PAPSS Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; skeletal system development [GO:0001501]; sulfate assimilation [GO:0000103] cytosol [GO:0005829] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; sulfate adenylyltransferase (ATP) activity [GO:0004781] AWTVLTEYYK 1 1.6 0.80531 0.01376 0 0 0 0 0 0 0 0 7.51743 0 0 0 O43264 ZW10_HUMAN Centromere/kinetochore protein zw10 homolog ZW10 Homo sapiens (Human) "cell division [GO:0051301]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic cell cycle [GO:0051321]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] centromeric DNA binding [GO:0019237] IRLVLEVLQKQLLDLPLDTDLENEK;LSEDIDLLK;LSEDIDLLKSR;VEEIKGEVCNMISK;YVTGAQRLEEAQK 5 8.1 0.9635 -1.2042 8.27076 8.35632 13.171 0 9.18535 0 0 0 0 7.49426 6.87271 8.78735 O43272 PROD_HUMAN "Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase) (Proline oxidase 2) (p53-induced gene 6 protein)" PRODH PIG6 POX2 PRODH2 Homo sapiens (Human) 4-hydroxyproline catabolic process [GO:0019470]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657] ERQLLWLELLRR;GTHRERQLLWLELLR 2 2.7 0.88076 -0.16957 0 5.93626 0 0 0 0 0 0 0 0 8.79591 0 O43278 SPIT1_HUMAN Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1) SPINT1 HAI1 UNQ223/PRO256 Homo sapiens (Human) branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to BMP stimulus [GO:0071773]; epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; positive regulation of glial cell differentiation [GO:0045687] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] GVQGGPLRGSSGAQATFPQGPSMER;VQPQEPLVLK 2 6.6 0.93707 -0.5644 0 0 0 10.3348 0 0 0 5.61844 0 0 0 0 O43280 TREA_HUMAN "Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)" TREH TREA Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; trehalose catabolic process [GO:0005993]; trehalose metabolic process [GO:0005991] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] "alpha,alpha-trehalase activity [GO:0004555]" DSPQFLQKISDAK;YRILRSQR 2 3.6 0.97392 -1.4026 0 0 0 0 0 9.99095 0 0 0 0 0 0 O43281 EFS_HUMAN Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) EFS CASS3 Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] protein domain specific binding [GO:0019904]; SH3 domain binding [GO:0017124] AIATSTQLAR 1 1.8 0.91551 -0.36654 0 0 0 0 12.3473 0 0 0 0 0 0 0 O43283 M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) MAP3K13 LZK Homo sapiens (Human) JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon extension [GO:0045773]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; IkappaB kinase complex binding [GO:0106137]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674] LEDRLAEK 1 0.8 0.97709 -1.4988 13.1817 0 0 0 0 0 0 0 0 0 0 0 O43286 B4GT5_HUMAN "Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)" B4GALT5 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycoprotein biosynthetic process [GO:0009101]; glycosylation [GO:0070085]; neuron maturation [GO:0042551]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; positive regulation of embryonic development [GO:0040019]; protein glycosylation [GO:0006486]; regulation of protein stability [GO:0031647] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]" GEVQFLGRYALLR;GLLRLPRR;TIGAQVYEQVLRSAYAK;VAILIPFR 4 11.9 0.96563 -1.2394 0 9.36798 0 0 0 8.32939 10.5113 0 0 0 0 0 O43291 SPIT2_HUMAN Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin) SPINT2 HAI2 KOP Homo sapiens (Human) basement membrane organization [GO:0071711]; cellular response to BMP stimulus [GO:0071773]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell motility [GO:2000146]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] ALRTVWSSGDDK;SIHDFCLVSK 2 8.7 0.91716 -0.41919 0 10.7333 9.96766 0 0 0 0 0 0 0 0 0 O43293 DAPK3_HUMAN Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) DAPK3 ZIPK Homo sapiens (Human) apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to type II interferon [GO:0071346]; intracellular signal transduction [GO:0035556]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; regulation of focal adhesion assembly [GO:0051893]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; regulation of myosin II filament organization [GO:0043519]; regulation of smooth muscle contraction [GO:0006940] "chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; spindle [GO:0005819]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] IEAGNEFK 1 1.8 0.9258 -0.45216 0 0 0 0 0 0 0 0 9.63494 0 0 0 O43294 TGFI1_HUMAN Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) TGFB1I1 ARA55 Homo sapiens (Human) cell adhesion [GO:0007155]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; Wnt signaling pathway [GO:0016055] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363] I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; Roundabout binding [GO:0048495]; transcription coactivator activity [GO:0003713] DGAPFCPECYFER;RGSLCATCGLPVTGR 2 6.1 0.84601 -0.057439 3.64097 0 0 5.91394 0 0 0 0 0 0 0 0 O43295 SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) SRGAP3 ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096] ASEDWWEGR;FDYMGRSPR;HEDRPQRR;LYFRGLENPLFPKER;QAKYSENK;SLEKLAER;VHQIQQILVTLPRVVIVVMR 7 7 0.97894 -2.0475 0 10.2131 0 0 0 0 0 0 0 10.2856 7.63641 0 O43298 ZBT43_HUMAN Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) ZBTB43 KIAA0414 ZBTB22B ZNF297B Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase III general transcription initiation factor binding [GO:0001025]; sequence-specific double-stranded DNA binding [GO:1990837]" IVLPDVMNPR;VEAEFDEQADESNYDEQVDFYGSSMEEFSGER 2 9 0.94591 -0.65459 0 0 0 0 0 0 0 0 0 0 7.13422 0 O43299 AP5Z1_HUMAN AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) AP5Z1 KIAA0415 SPG48 Homo sapiens (Human) autophagosome assembly [GO:0000045]; axon development [GO:0061564]; double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; gene expression [GO:0010467]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; late endosome to Golgi transport [GO:0034499]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; lysosome [GO:0005764]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LASRSQDLIPRASLLLSK;LFLIISATKYSR 2 3.7 0.81621 -0.0030684 0 0 0 7.60659 0 0 0 0 0 0 6.65263 0 O43303 CP110_HUMAN Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) CCP110 CEP110 CP110 KIAA0419 Homo sapiens (Human) centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] FLVKQNPSETRVLQPNQGQNAPVHR;WSQVFSLEIQAK 2 3.7 0.86633 -0.088733 0 0 0 9.91392 0 0 7.89966 0 0 0 0 0 O43304 S14L5_HUMAN SEC14-like protein 5 SEC14L5 KIAA0420 Homo sapiens (Human) cytoplasm [GO:0005737] LGAREPGTRASGQLIDK 1 2.4 0.84879 -0.076534 0 0 0 0 0 0 0 0 0 0 0 13.0247 O43306 ADCY6_HUMAN Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) ADCY6 KIAA0422 Homo sapiens (Human) adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; blood vessel diameter maintenance [GO:0097746]; cAMP biosynthetic process [GO:0006171]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to forskolin [GO:1904322]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vasopressin [GO:1904117]; intracellular signal transduction [GO:0035556]; negative regulation of neuron projection development [GO:0010977]; negative regulation of urine volume [GO:0035811]; renal water homeostasis [GO:0003091] cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080] ALQRLSR;SIDQLRKDHVR 2 1.5 0.9807 -1.6342 0 0 0 0 0 0 0 0 0 9.25013 0 9.64202 O43307 ARHG9_HUMAN Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9) ARHGEF9 ARHDH9 KIAA0424 Homo sapiens (Human) regulation of postsynaptic specialization assembly [GO:0099150]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] guanyl-nucleotide exchange factor activity [GO:0005085] DILYYKGR;NVTQQINER;SQSPFWQNFSR 3 5.4 0.97396 -2.4132 9.46765 0 0 0 0 0 0 0 0 0 0 10.4289 O43309 ZSC12_HUMAN Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96) ZSCAN12 KIAA0426 ZNF305 ZNF96 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HYHCNDCGK 1 1.5 0.6752 0.16649 0 0 7.57841 0 0 0 0 0 0 0 0 0 O43310 CTIF_HUMAN CBP80/20-dependent translation initiation factor CTIF KIAA0427 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]" cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; translation activator activity [GO:0008494] RWHHGNMK;SFAFTAAKLCDK;WLGFITFLCEVFGTMR 3 6 0.95452 -0.88573 0 0 0 0 0 0 8.56898 0 0 8.90412 0 0 O43312 MTSS1_HUMAN Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of actin filament bundle assembly [GO:0032233]; renal tubule morphogenesis [GO:0061333] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726] actin binding [GO:0003779]; actin monomer binding [GO:0003785]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102] GGTREIGSALTR;TTTNDRSAPRFS 2 3.2 0.98037 -1.6425 0 0 0 0 0 0 0 0 7.66278 10.4573 0 0 O43313 ATMIN_HUMAN ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822) ATMIN KIAA0431 ZNF822 Homo sapiens (Human) DNA damage response [GO:0006974]; motile cilium assembly [GO:0044458]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; dynein complex binding [GO:0070840]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]" CTCGCPYASR;QHFMKMHAEK;YPQKLLLPKPKVALVK 3 4.4 0.81341 -0.010221 10.1462 0 0 0 0 3.83036 0 0 7.08926 0 0 0 O43314 VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) PPIP5K2 HISPPD1 KIAA0433 VIP2 Homo sapiens (Human) inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; sensory perception of sound [GO:0007605] cytosol [GO:0005829] "5-diphosphoinositol pentakisphosphate 1-kinase activity [GO:0033857]; ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" AVAYAKLR;LRNPFVINDLNMQYLIQDRR;VYSLIQSLTSQIR 3 3.1 0.97278 -2.7728 7.42668 0 3.78283 9.67393 6.90376 0 8.49173 0 0 8.62673 6.74672 0 O43316 PAX4_HUMAN Paired box protein Pax-4 PAX4 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; forebrain development [GO:0030900]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; sensory organ development [GO:0007423]; type B pancreatic cell differentiation [GO:0003309] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLRALQEDQGLPCTRLR 1 4.9 0.50579 0.18783 0 0 0 8.83555 0 0 0 0 0 0 0 0 O43318 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) MAP3K7 TAK1 Homo sapiens (Human) "anoikis [GO:0043276]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of gene expression [GO:0010629]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; p38MAPK cascade [GO:0038066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell size [GO:0045793]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macroautophagy [GO:0016239]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; transforming growth factor beta receptor signaling pathway [GO:0007179]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]" ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; histone kinase activity [GO:0035173]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; linear polyubiquitin binding [GO:1990450]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase kinase activity [GO:0004709]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; transcription coactivator binding [GO:0001223]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625] DLKPPNLLLVAGGTVLK;EIEVEEVVGR;LSLGASRGSSVESLPPTSEGK;QIESESERK 4 9.4 0.96462 -1.197 0 4.24092 0 9.84964 0 9.84825 9.97656 9.77785 0 0 0 0 O43323 DHH_HUMAN Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)] DHH Homo sapiens (Human) cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; myelination [GO:0042552]; osteoblast differentiation [GO:0001649]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; regulation of steroid biosynthetic process [GO:0050810]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; self proteolysis [GO:0097264]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286] endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270] DLQRRASFVAVETEWPPR;GSERFRDLVPNYNPDIIFK 2 9.3 0.95861 -1.0071 0 0 0 0 0 0 11.4152 11.3958 11.0291 0 8.52105 0 O43324 MCA3_HUMAN Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18) EEF1E1 AIMP3 P18 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; translation [GO:0006412]" aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AAAAELSLLEK 1 6.3 0 3.3821 0 10.5912 10.5555 0 0 8.80067 0 0 0 8.61644 0 0 O43345 ZN208_HUMAN Zinc finger protein 208 (Zinc finger protein 91-like) ZNF208 ZNF91L Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" IHTGETPYK;IRHTGKK;SSSTLSYHKK;VIHTGEK 4 9.3 0.92967 -0.48632 0 8.75799 0 0 0 0 0 0 0 0 0 9.86016 O43347 MSI1H_HUMAN RNA-binding protein Musashi homolog 1 (Musashi-1) MSI1 Homo sapiens (Human) central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]; response to hormone [GO:0009725] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] EYFGQFGEVKECLVMRDPLTK 1 5.8 0.86407 -0.083824 0 0 0 0 0 0 0 0 0 6.94181 0 0 O43353 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 Homo sapiens (Human) "activation of cysteine-type endopeptidase activity [GO:0097202]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to peptidoglycan [GO:0071224]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; ERK1 and ERK2 cascade [GO:0070371]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of xenophagy [GO:1904417]; protein homooligomerization [GO:0051260]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to interleukin-12 [GO:0070671]; response to interleukin-18 [GO:0070673]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; xenophagy [GO:0098792]" cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; LIM domain binding [GO:0030274]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102] GASGTVSSARHADWR;LQPGIAQQWIQSKR;QLLDTTDIQGEEFAK;SAPEGGTIIYMPPENYEPGQK 4 12 0.91608 -0.43032 11.1425 0 10.9599 0 0 0 0 0 0 0 13.0128 0 O43361 ZN749_HUMAN Zinc finger protein 749 ZNF749 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SHLVQHEKIHTDAFSK 1 2.1 0.88072 -0.16826 0 0 0 0 0 0 0 0 0 0 7.18775 0 O43374 RASL2_HUMAN Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) RASA4 CAPRI GAPL KIAA0538 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of Ras protein signal transduction [GO:0046580] cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] DITGSSDPYCIVKVDNEPIIR;LVDIEEK 2 3.5 0.91629 -0.34716 0 0 0 0 0 0 10.3102 0 0 0 0 9.95294 O43379 WDR62_HUMAN WD repeat-containing protein 62 WDR62 C19orf14 Homo sapiens (Human) centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; regulation of centrosome cycle [GO:0046605]; regulation of neuron differentiation [GO:0045664] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole [GO:0000922] HIVSMGYQHDMVLNVWDWK;IFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRK;LQTTFQEALDLYR;VMQVSPDGQHLASGDRSGNLR 4 5.9 0.95557 -0.8743 0 11.2032 0 0 0 5.55919 0 0 12.3849 8.74393 0 0 O43390 HNRPR_HUMAN Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729]; RNA binding [GO:0003723] AGPIWDLR;DLYEDELVPLFEK;DYAFVHFEDRGAAVK;KADGYNQPDSKR;LFVGSIPK;NLATTVTEEILEK;NRGFCFLEYEDHK;SAAQARR;TGYTLDVTTGQR;TLIEAGLPQK 10 17.5 0 13.306 12.7579 13.5266 12.3766 8.81455 9.43831 9.98598 11.962 10.7367 11.0965 11.5275 11.5061 11.7426 O43395 PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) PRPF3 HPRP3 PRP3 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]" Cajal body [GO:0015030]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] identical protein binding [GO:0042802]; RNA binding [GO:0003723] ELKEVFGDDSEISK;TNKCVLVWEGTAK 2 4 0.954 -0.88906 0 0 0 7.65871 6.42578 0 0 0 0 6.30805 0 0 O43396 TXNL1_HUMAN Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) TXNL1 TRP32 TXL TXNL Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502] disulfide oxidoreductase activity [GO:0015036]; protein-disulfide reductase activity [GO:0015035] AGCECLNESDEHGFDNCLR;FQGPDNGQGPKYVKIFINLPR 2 13.8 0.34845 0.23587 0 8.2255 0 7.10884 0 0 0 0 0 0 0 5.3658 O43399 TPD54_HUMAN Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; regulation of cell population proliferation [GO:0042127] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] QNLSRSWHDVQVSSAYVK;TSAALSTVGSAISR;VEEEIVTLR 3 19.9 0.94588 -0.65393 0 0 0 0 0 0 0 0 9.85348 10.5437 0 0 O43402 EMC8_HUMAN ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) EMC8 C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4 Homo sapiens (Human) protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] NDWTNPEINKAVLHLC 1 7.6 0.91591 -0.43091 0 10.7747 11.5353 0 0 0 0 0 0 0 0 0 O43405 COCH_HUMAN Cochlin (COCH-5B2) COCH COCH5B2 UNQ257/PRO294 Homo sapiens (Human) regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] collagen binding [GO:0005518] LCTHEQMMCSK 1 2 0.80966 0.0099649 0 0 4.58532 0 0 0 0 0 0 0 0 0 O43422 P52K_HUMAN 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) THAP12 DAP4 P52RIPK PRKRIR THAP0 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] ETLSVPTVEHIIQELKDIFSEQHLK;QKKIDETSEQEQK 2 5 0.78165 0.021369 8.91955 0 0 0 0 0 0 0 0 0 0 0 O43424 GRID2_HUMAN "Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)" GRID2 GLURD2 Homo sapiens (Human) "cerebellar granule cell differentiation [GO:0021707]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; glutamate receptor signaling pathway [GO:0007215]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; prepulse inhibition [GO:0060134]; protein localization [GO:0008104]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of presynapse assembly [GO:1905606]; synaptic signaling via neuropeptide [GO:0099538]; synaptic transmission, glutamatergic [GO:0035249]" dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202] glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] KNSKPWQGGR;QALEQISDFR 2 2 0.96783 -1.3269 0 0 0 0 0 0 10.7343 0 0 0 0 0 O43426 SYNJ1_HUMAN "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" SYNJ1 KIAA0910 Homo sapiens (Human) inositol phosphate metabolic process [GO:0043647]; learning [GO:0007612]; membrane organization [GO:0061024]; neurotransmitter transport [GO:0006836]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of endosome organization [GO:1904980]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; synaptic vesicle uncoating [GO:0016191] clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; membrane coat [GO:0030117]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; synaptic membrane [GO:0097060]; terminal bouton [GO:0043195]; vesicle membrane [GO:0012506] "inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; RNA binding [GO:0003723]" ERNEDFIEIAR 1 0.7 0.91822 -0.40443 0 0 0 7.24707 0 6.88813 0 0 0 7.71363 0 8.89312 O43427 FIBP_HUMAN Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) FIBP Homo sapiens (Human) fibroblast growth factor receptor signaling pathway [GO:0008543]; platelet aggregation [GO:0070527] endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] fibroblast growth factor binding [GO:0017134] LLHAPPK;SGILEQTGATAAVLQSDTMDHYRTFHMLER 2 10.2 0.73194 0.11805 0 0 0 0 0 8.98353 0 0 7.07906 0 0 0 O43432 IF4G3_HUMAN Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; spermatid development [GO:0007286]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; intracellular non-membrane-bounded organelle [GO:0043232] "mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" AALSEEELERKSK;GSSGGAK;ILPRGPDFTPAFADFGRQTPGGR;KAENAWKPSQK;LLTTIGK;NSTEAERNK;TLTSRGSMGREK;VPMADKPGNTVNFRKLLLNR 8 6.4 0.97385 -1.3954 10.597 0 0 0 8.32224 4.56468 0 0 9.26831 9.43661 0 10.3492 O43435 TBX1_HUMAN T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein) TBX1 Homo sapiens (Human) angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aorta morphogenesis [GO:0035909]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; coronary artery morphogenesis [GO:0060982]; determination of left/right symmetry [GO:0007368]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; enamel mineralization [GO:0070166]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; lymph vessel development [GO:0001945]; mesenchymal cell apoptotic process [GO:0097152]; mesoderm development [GO:0007498]; middle ear morphogenesis [GO:0042474]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell differentiation [GO:0045596]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; parathyroid gland development [GO:0060017]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tongue muscle cell differentiation [GO:2001037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of animal organ morphogenesis [GO:2000027]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; soft palate development [GO:0060023]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tongue morphogenesis [GO:0043587]; vagus nerve morphogenesis [GO:0021644] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DCDPEDWPR;DSEKYAEENFK 2 5 0.98091 -1.632 0 5.52328 0 0 0 0 10.6872 0 10.5425 9.95818 0 0 O43439 MTG8R_HUMAN Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) CBFA2T2 EHT MTGR1 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of neuron projection development [GO:0010976] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AVAEAEQK;MVGVPGAAAFQLGPEKR 2 4.2 0.89242 -0.22447 0 0 0 0 0 0 0 0 8.7184 0 0 0 O43448 KCAB3_HUMAN Voltage-gated potassium channel subunit beta-3 (EC 1.1.1.-) (K(+) channel subunit beta-3) (Kv-beta-3) KCNAB3 KCNA3B Homo sapiens (Human) potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] aldo-keto reductase (NADPH) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] KHIIEGLRGSLER 1 3.2 0.86554 -0.090261 0 0 0 10.7119 0 0 0 0 0 0 0 0 O43451 MGA_HUMAN "Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)" MGAM MGA MGAML Homo sapiens (Human) dextrin catabolic process [GO:1901027]; maltose catabolic process [GO:0000025]; starch catabolic process [GO:0005983] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] "alpha-1,4-glucosidase activity [GO:0004558]; amylase activity [GO:0016160]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; glucan 1,4-alpha-glucosidase activity [GO:0004339]; oligo-1,6-glucosidase activity [GO:0004574]" LDVTYHK;TLCMDAVQHWGK 2 0.9 0.95207 -0.75546 0 0 0 0 8.0706 0 0 8.77939 0 0 0 0 O43462 MBTP2_HUMAN Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) MBTPS2 S2P Homo sapiens (Human) ATF6-mediated unfolded protein response [GO:0036500]; bone maturation [GO:0070977]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein maturation [GO:0051604]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; transcription regulator activator activity [GO:0140537] AVEATQVCRTNK;MIPVSLVVVVVGGWTVVYLTDLVLK;TNKDCKK 3 7.9 0.97621 -1.4862 0 0 4.1672 0 0 8.08635 0 0 0 0 0 0 O43463 SUV91_HUMAN Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) SUV39H1 KMT1A SUV39H Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; rDNA heterochromatin formation [GO:0000183]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364] "chromatin silencing complex [GO:0005677]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; cytoplasmic vesicle [GO:0031410]; eNoSc complex [GO:0061773]; heterochromatin [GO:0000792]; nuclear lamina [GO:0005652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]" chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone methyltransferase activity [GO:0042054]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] AENLKGCSVCCK;CRCGYDCPNR;LSCPALGISK 3 7.8 0.95262 -0.75731 10.2579 12.5276 12.4684 4.42787 0 0 6.20492 12.0797 0 12.0899 12.2225 0 O43464 HTRA2_HUMAN "Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)" HTRA2 OMI PRSS25 Homo sapiens (Human) adult walking behavior [GO:0007628]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; ceramide metabolic process [GO:0006672]; execution phase of apoptosis [GO:0097194]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of type 2 mitophagy [GO:1905090]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; pentacyclic triterpenoid metabolic process [GO:0019742]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of protein targeting to mitochondrion [GO:1903955]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of multicellular organism growth [GO:0040014]; response to herbicide [GO:0009635] CD40 receptor complex [GO:0035631]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; serine-type endopeptidase complex [GO:1905370] identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein serine/threonine kinase inhibitor activity [GO:0030291]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; ubiquitin ligase inhibitor activity [GO:1990948]; unfolded protein binding [GO:0051082] GAGWSLRAWR;GEKKNSSSGISGSQR 2 5.5 0.98077 -1.6079 11.8537 0 0 0 0 0 0 0 6.62319 0 0 0 O43474 KLF4_HUMAN Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) KLF4 EZF GKLF Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to tumor cell [GO:0002357]; epidermal cell differentiation [GO:0009913]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; glandular epithelial cell differentiation [GO:0002067]; mesodermal cell fate determination [GO:0007500]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; post-embryonic hemopoiesis [GO:0035166]; regulation of axon regeneration [GO:0048679]; regulation of blastocyst development [GO:0120222]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; euchromatin [GO:0000791]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [GO:0001010]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" FARSDELTRHYR;TTPTLGLEEVLSSR 2 5.1 0.87639 -0.13241 0 0 0 0 10.7111 0 0 0 0 0 0 0 O43488 ARK72_HUMAN Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) AKR7A2 AFAR AFAR1 AKR7 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; carbohydrate metabolic process [GO:0005975]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] "aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; electron transfer activity [GO:0009055]; phenanthrene-9,10-epoxide hydrolase activity [GO:0019119]" AAVHCALR;FYAYNPLAGGLLTGK;SQLETSLKR 3 8.9 0.95503 -0.83436 0 0 0 0 0 0 0 0 0 7.99932 11.3689 9.38812 O43490 PROM1_HUMAN Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) PROM1 PROML1 MSTP061 Homo sapiens (Human) camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; photoreceptor cell maintenance [GO:0045494]; podocyte differentiation [GO:0072112]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; vesicle [GO:0031982] actinin binding [GO:0042805]; cadherin binding [GO:0045296]; cholesterol binding [GO:0015485] AGPIGILFELVHIFLYVVQPR;ATVFLLPALIFAVKLAKYYR;CCNKCGGEMHQR;LAKYYRR;QTTTVVAGIK;SMATAIK;TIIGYFEHYLQWIEFSISEK;YILAQYNTTKDK 8 11.9 0.97664 -2.192 0 13.3171 0 0 0 0 5.35364 9.13712 3.19716 0 0 9.31293 O43491 E41L2_HUMAN Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) EPB41L2 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein localization to cell cortex [GO:1904778] cell cortex [GO:0005938]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spectrin [GO:0008091] actin binding [GO:0003779]; PH domain binding [GO:0042731]; spectrin binding [GO:0030507]; structural molecule activity [GO:0005198] AEKASQK;ASQKVTKK;TTEVGSVSEVKKDSSQLGTDATK 3 3.4 0.97575 -2.3463 0 0 0 0 0 0 0 10.8167 0 0 4.4167 0 O43493 TGON2_HUMAN Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) TGOLN2 TGN46 TGN51 Homo sapiens (Human) clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133] LSPHAFK;SSEPTEDVEPK 2 4.1 0.76333 0.065967 8.87649 0 9.24798 0 4.92343 7.71177 0 10.3316 0 10.2265 0 0 O43497 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1) CACNA1G KIAA1123 Homo sapiens (Human) AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell signaling [GO:0086027]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cardiac muscle cell action potential involved in contraction [GO:0086002]; chemical synaptic transmission [GO:0007268]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during SA node cell action potential [GO:0086046]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane potential [GO:0042391]; response to nickel cation [GO:0010045]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell signaling [GO:0086018]; sinoatrial node development [GO:0003163] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059] DEEEDGAGAEESGQPR;LLRTLRPLRVISR;THSLPNDSYMCR;VLRLLRTLRPLR 4 1.9 0.57822 0.18094 0 0 0 5.36751 0 5.88523 0 0 0 0 0 0 O43502 RA51C_HUMAN DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) RAD51C RAD51L2 Homo sapiens (Human) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; sister chromatid cohesion [GO:0007062]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677] LIFHWDR 1 1.9 0.93013 -0.48024 0 0 0 9.94863 0 0 0 0 12.3856 0 0 0 O43505 B4GA1_HUMAN "Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)" B4GAT1 B3GNT1 B3GNT6 Homo sapiens (Human) axon guidance [GO:0007411]; keratan sulfate biosynthetic process [GO:0018146]; protein O-linked mannosylation [GO:0035269] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]" EAENQHNK;VAMHLVCPSR 2 4.3 0.93195 -0.49109 0 0 0 0 0 0 9.49446 0 0 0 8.57334 0 O43506 ADA20_HUMAN Disintegrin and metalloproteinase domain-containing protein 20 (ADAM 20) (EC 3.4.24.-) ADAM20 Homo sapiens (Human) male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GAKAPGWLSYSLRFGGQR;YLSLLCLLPLVAFLLFCLHVLFKKR 2 5.9 0.95511 -0.78901 0 0 9.75109 0 0 0 0 0 0 5.76842 0 0 O43508 TNF12_HUMAN "Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]" TNFSF12 APO3L DR3LG UNQ181/PRO207 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; endothelial cell migration [GO:0043542]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein catabolic process [GO:0045732]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] TLPWAHLK 1 3.2 0.93689 -0.54942 0 0 0 0 0 0 0 0 0 9.92935 10.1093 0 O43511 S26A4_HUMAN Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) SLC26A4 PDS Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; inorganic anion transport [GO:0015698]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; iodide transmembrane transporter activity [GO:0015111]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116] IAILALGKLLEPLQKSVLAAVVIANLK;IDVNVYFASLQDYVIEKLEQCGFFDDNIR;MIAILALGKLLEPLQKSVLAAVVIANLK 3 16.3 0.25638 0.27022 0 0 10.1794 6.51978 0 0 0 0 6.54915 0 0 0 O43513 MED7_HUMAN Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33) MED7 ARC34 CRSP9 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] ETLRVMMEVQK 1 4.7 0.95161 -0.70173 0 0 0 0 0 0 0 9.75584 0 0 0 0 O43516 WIPF1_HUMAN WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) WIPF1 WASPIP WIP Homo sapiens (Human) actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; protein-containing complex assembly [GO:0065003]; response to other organism [GO:0051707] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ruffle [GO:0001726] actin binding [GO:0003779]; profilin binding [GO:0005522]; protein folding chaperone [GO:0044183]; SH3 domain binding [GO:0017124] NESRSEYFCQGF 1 2.4 0.92447 -0.44851 0 0 0 0 5.37657 0 0 0 0 0 0 0 O43520 AT8B1_HUMAN Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) ATP8B1 ATPIC FIC1 PFIC Homo sapiens (Human) apical protein localization [GO:0045176]; bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; Golgi organization [GO:0007030]; inner ear receptor cell development [GO:0060119]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; regulation of microvillus assembly [GO:0032534]; regulation of plasma membrane organization [GO:1903729]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve formation [GO:0021650]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; cardiolipin binding [GO:1901612]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] ALIITGSWLNEILLEKK;EIEEKEFTEWNK;FPRTEEER;TLCLCYK;TLCLCYKEIEEK;VYEEIEK 6 4.1 0.97524 -3.1821 0 0 0 4.06134 0 0 10.1366 0 10.9424 0 0 11.2024 O43525 KCNQ3_HUMAN Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) KCNQ3 Homo sapiens (Human) action potential initiation [GO:0099610]; apoptosome assembly [GO:0097314]; cellular response to calcium ion [GO:0071277]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; excitatory chemical synaptic transmission [GO:0098976]; exocytosis [GO:0006887]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]; membrane hyperpolarization [GO:0060081]; mitochondrial depolarization [GO:0051882]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; neuron remodeling [GO:0016322]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein import into nucleus [GO:0006606]; protein targeting [GO:0006605]; psychomotor behavior [GO:0036343]; regulation of action potential firing threshold [GO:0099611]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; response to organic cyclic compound [GO:0014070]; sensory perception of sound [GO:0007605]; substantia propria of cornea development [GO:1903701] axon initial segment [GO:0043194]; cell surface [GO:0009986]; mitochondrion [GO:0005739]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249] EPKPVGLNNK;GGPSSGK;LSNPRGSNTK;VQEQHRQKHFEK 4 4.5 0.98075 -1.6032 0 0 0 0 0 0 0 0 7.03232 0 10.754 7.5421 O43526 KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) KCNQ2 Homo sapiens (Human) action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; nervous system development [GO:0007399]; potassium ion transmembrane transport [GO:0071805] axon initial segment [GO:0043194]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249] GPAITDKDRTK;LDFLVNIYMQR;LIPPLNQLELLRNLKSK;SWSFGDR;SWSFGDRSR;VQEQHRQKHFEK 6 6.9 0.97608 -1.4815 0 4.19999 0 0 0 4.78952 11.1092 10.8311 7.2241 0 0 0 O43541 SMAD6_HUMAN Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) SMAD6 MADH6 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell-substrate adhesion [GO:0031589]; coronary vasculature development [GO:0060976]; fat cell differentiation [GO:0045444]; immune response [GO:0006955]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of miRNA transcription [GO:1902895]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; SMAD protein signal transduction [GO:0060395]; ureteric bud development [GO:0001657]; ventricular septum development [GO:0003281]; zygotic specification of dorsal/ventral axis [GO:0007352] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; heteromeric SMAD protein complex [GO:0071144]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; type I activin receptor binding [GO:0070698]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625] EEGGSGGGGGGDEDGSLGSR 1 4 0.89273 -0.22418 0 0 0 0 0 0 0 0 0 0 5.36489 0 O43541 SMAD6_HUMAN Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6) SMAD6 MADH6 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell-substrate adhesion [GO:0031589]; coronary vasculature development [GO:0060976]; fat cell differentiation [GO:0045444]; immune response [GO:0006955]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of miRNA transcription [GO:1902895]; pulmonary valve morphogenesis [GO:0003184]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; SMAD protein signal transduction [GO:0060395]; ureteric bud development [GO:0001657]; ventricular septum development [GO:0003281]; zygotic specification of dorsal/ventral axis [GO:0007352] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; heteromeric SMAD protein complex [GO:0071144]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]; type I activin receptor binding [GO:0070698]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625] MSRMGKPIETQK 1 5.1 0.92357 -0.44776 0 0 0 9.57249 0 0 0 0 0 0 0 0 O43543 XRCC2_HUMAN DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) XRCC2 Homo sapiens (Human) centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756] centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677] CSQCLEKLVNDYR 1 4.6 0.92246 -0.44712 0 0 0 8.03083 0 0 10.0541 0 0 0 0 0 O43556 SGCE_HUMAN Epsilon-sarcoglycan (Epsilon-SG) SGCE ESG UNQ433/PRO840 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; muscle organ development [GO:0007517] cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dystrophin-associated glycoprotein complex [GO:0016010]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] EVENPQNQLR;LTEAMNL;TQFYIDWCKISLVDKTK 3 7.5 0.95104 -0.69638 0 0 11.7922 0 0 0 0 0 9.02409 0 0 0 O43559 FRS3_HUMAN Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2) FRS3 Homo sapiens (Human) fibroblast growth factor receptor signaling pathway [GO:0008543]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; identical protein binding [GO:0042802]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] ALPRDDGTAR;TVAMSNLQR 2 3.9 0.98129 -1.707 0 0 12.7695 0 0 0 0 0 0 0 0 0 O43567 RNF13_HUMAN E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) RNF13 RZF Homo sapiens (Human) organelle localization [GO:0051640]; positive regulation of JNK cascade [GO:0046330]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654] JUN kinase binding [GO:0008432]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LDCNFDIKVLNAQRAGYK 1 4.7 0.51146 0.18761 0 0 12.2648 0 0 0 0 0 0 0 0 0 O43570 CAH12_HUMAN Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) CA12 Homo sapiens (Human) chloride ion homeostasis [GO:0055064]; estrous cycle [GO:0044849]; one-carbon metabolic process [GO:0006730] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] PRRSLHAAAVLLLVILK;RSLHAAAVLLLVILK;SLHAAAVLLLVILK 3 4.8 0.91687 -0.40999 0 0 0 0 0 0 6.2098 0 5.62699 0 3.67016 0 O43572 AKA10_HUMAN "A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)" AKAP10 Homo sapiens (Human) protein localization [GO:0008104]; signal transduction [GO:0007165] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] protein kinase A binding [GO:0051018] SIKASISVHSPQK;TLRPDPGPAMSFFRR 2 4.2 0.96306 -1.1048 9.26301 0 0 0 0 0 0 0 0 0 0 0 O43581 SYT7_HUMAN Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) SYT7 PCANAP7 Homo sapiens (Human) calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]" AINGTLLSGAKVAAAAGLAVER;NDPIGEVSIPLNKVDLTQMQTFWK;VAAAAGLAVEREGR 3 10.3 0.88319 -0.17261 0 0 0 0 0 0 0 10.3087 0 0 0 0 O43581 SYT7_HUMAN Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) SYT7 PCANAP7 Homo sapiens (Human) calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]" NDPIGEVSIPLNKVDLTQMQTFWK;NRGLDMKSFLEGR;VAAAAGLAVEREGR 3 7.4 0.97991 -1.6539 0 0 0 0 0 10.1223 0 0 0 0 8.66146 10.473 O43583 DENR_HUMAN Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) DENR DRP1 H14 Homo sapiens (Human) formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]; translation reinitiation [GO:0002188] cytoplasm [GO:0005737] translation initiation factor activity [GO:0003743] LDADYPLR;TVPQKVTIAKIPR 2 10.6 0.91621 -0.34866 0 0 0 0 4.68297 0 0 0 0 0 0 0 O43586 PPIP1_HUMAN Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) PSTPIP1 CD2BP1 Homo sapiens (Human) actin filament polymerization [GO:0030041]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165] actin filament [GO:0005884]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] SLEEFRER 1 1.9 0.96776 -1.2967 0 0 0 0 0 0 11.1506 0 11.8073 0 0 10.8201 O43592 XPOT_HUMAN Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Homo sapiens (Human) intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]; tRNA re-export from nucleus [GO:0071528] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] FFCFQVLEHQVK;ILMAIDSELVDR;LLLDRLAQVSPELLLASVRR;VFKNYLK 4 5.3 0.95532 -0.81135 0 0 0 0 10.2504 0 0 0 4.94944 0 7.49769 0 O43593 HAIR_HUMAN Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) HR Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AQDAQRIRR;CCSRCHHGLFNTHWR;LPPPGALLWLQEPQPCPRR 3 3.6 0.9806 -1.6643 0 0 0 0 0 9.86426 9.24907 4.27098 0 0 0 0 O43602 DCX_HUMAN Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) DCX DBCN LISX Homo sapiens (Human) axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005] microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] KTAHSFEQVLTDITEAIKLETGVVK;LVTIIRSGVKPRK 2 10.4 0.66057 0.16893 0 6.75395 0 0 0 0 0 0 0 0 0 0 O43614 OX2R_HUMAN Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]" plasma membrane [GO:0005886]; synapse [GO:0045202] neuropeptide receptor activity [GO:0008188]; orexin receptor activity [GO:0016499]; peptide hormone binding [GO:0017046] LWCRQIPGTSSVVQR;SLTTQISNFDNISK 2 6.5 0.93372 -0.51155 0 0 0 0 0 0 0 0 0 0 10.1509 10.869 O43615 TIM44_HUMAN Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 MIMT44 TIM44 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626] fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] ATP binding [GO:0005524]; protein-folding chaperone binding [GO:0051087] GFLSGLLDNVK;MMEQGPVLIITFQAQLVMVVR;WYQQWKDFK 3 9.1 0.97383 -1.4093 0 0 0 0 0 0 0 0 0 0 8.44112 0 O43617 TPPC3_HUMAN Trafficking protein particle complex subunit 3 (BET3 homolog) TRAPPC3 BET3 CDABP0066 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] LIEDFLARSNVGRCHDFR 1 10 0.5384 0.18508 0 0 0 0 0 10.9614 0 0 0 0 0 0 O43633 CHM2A_HUMAN Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) CHMP2A BC2 CHMP2 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of centriole elongation [GO:1903723]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; chromatin [GO:0000785]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] phosphatidylcholine binding [GO:0031210]; protein domain specific binding [GO:0019904] QNQRALNR 1 3.6 0.91423 -0.33804 0 0 12.0651 0 0 0 0 0 0 0 0 0 O43638 FOXS1_HUMAN Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10) FOXS1 FKHL18 FREAC10 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; neuromuscular process controlling balance [GO:0050885]; positive regulation of multicellular organism growth [GO:0040018]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FAFYRHNRPGWQNSIR 1 4.8 0.91589 -0.4308 0 0 0 0 0 0 0 0 0 6.19928 0 0 O43639 NCK2_HUMAN Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) NCK2 GRB4 Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; vesicle membrane [GO:0012506] cytoskeletal anchor activity [GO:0008093]; phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159] ASGKNKHFK;DTLGLGK;DTLGLGKTR;KGASLSNGQGSR;LYLVRALQ;VQLVDNVYCIGQRR 6 13.7 0.98093 -1.6916 8.15831 0 0 0 9.78733 0 0 0 0 11.1934 0 0 O43660 PLRG1_HUMAN Pleiotropic regulator 1 PLRG1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]" catalytic step 2 spliceosome [GO:0071013]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] GVIVSTRSPYLFSCGEDK;QVKCWDLEYNK 2 5.6 0.94183 -0.61899 10.9976 0 0 0 0 0 0 0 9.82051 0 0 0 O43663 PRC1_HUMAN Protein regulator of cytokinesis 1 PRC1 Homo sapiens (Human) cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cell population proliferation [GO:0008284]; regulation of cytokinesis [GO:0032465] chromosome [GO:0005694]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] ELLDMMIAEEESLKER;MQNMKKVIEAIR 2 4.5 0.94101 -0.59087 0 12.3763 0 0 0 0 0 0 0 5.38957 0 0 O43670 ZN207_HUMAN BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) ZNF207 BUGZ Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047] DNA binding [GO:0003677]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA binding [GO:0003723] ETIDAVPNAIPGR 1 2.7 0.13603 0.35432 0 0 4.61553 0 0 0 0 0 0 9.19763 0 0 O43674 NDUB5_HUMAN "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] HSGDHGK 1 3.7 0.6978 0.16173 0 0 0 0 0 0 0 0 7.08534 0 0 0 O43676 NDUB3_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) NDUFB3 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] MAHEHGHEHGHHK 1 13.3 0.80511 0.013689 0 0 0 0 0 0 0 0 6.8596 0 0 0 O43677 NDUC1_HUMAN "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)" NDUFC1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] VGFTLGTTVFLWIYLIK 1 22.4 0.63987 0.17298 0 9.16252 0 0 0 0 0 0 0 0 0 0 O43679 LDB2_HUMAN LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) epithelial structure maintenance [GO:0010669]; hair follicle development [GO:0001942]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cellular component biogenesis [GO:0044089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019] cell leading edge [GO:0031252]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; transcription coregulator activity [GO:0003712] LILEFTFDDLMR;QYRELVPR 2 6 0.95215 -0.7444 0 0 0 0 0 0 12.1134 0 0 0 0 0 O43683 BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) BUB1 BUB1L Homo sapiens (Human) "apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; mitotic spindle assembly checkpoint signaling [GO:0007094]; positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000720]; regulation of chromosome segregation [GO:0051983]; regulation of sister chromatid cohesion [GO:0007063]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2A kinase activity [GO:0140995]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EYLITLLEHLMK 1 1.1 0.89761 -0.23955 0 0 0 0 0 0 0 0 0 0 0 10.3421 O43684 BUB3_HUMAN Mitotic checkpoint protein BUB3 BUB3 Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] bub1-bub3 complex [GO:1990298]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654] ubiquitin binding [GO:0043130] VAVEYLDPSPEVQK;VAVEYLDPSPEVQKK 2 4.6 0.88792 -0.20243 12.4209 0 0 0 0 0 0 0 0 0 9.37084 0 O43704 ST1B1_HUMAN Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] NYFTVAQNEK 1 3.4 0.93399 -0.50426 0 0 0 0 0 0 11.2518 0 0 0 0 0 O43707 ACTN4_HUMAN Alpha-actinin-4 (Non-muscle alpha-actinin 4) ACTN4 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of sodium:proton antiporter activity [GO:0032417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; retinoic acid receptor signaling pathway [GO:0048384]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; protein-containing complex [GO:0032991]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:1990904]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; integrin binding [GO:0005178]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transmembrane transporter binding [GO:0044325] ALDFIASK;ASIHEAWTDGK;DDPVTNLNNAFEVAEK;DHALLEEQSK;DLLLDPAWEK;DYETATLSDIK;EAMLKHR;ETTDTDTADQVIASFK;FAIQDISVEETSAK;GISQEQMQEFR;IAESNHIK;LDHLAEK;LDHLAEKFR;LSGSNPYTTVTPQIINSK;LVSIGAEEIVDGNAK;QFASQANVVGPWIQTK;QGEAEFNR;SFSTALYGESDL;STLPDADRER;TFTAWCNSHLRK;TINEVENQILTR;TIQEMQQK;VGWEQLLTTIAR;VLAVNQENEHLMEDYEK;VQQLVPK 25 30.5 0 171.9 14.0662 14.008 13.477 9.45327 10.7773 11.4446 14.4691 15.0429 14.5787 14.8482 14.5801 7.7845 O43711 TLX3_HUMAN T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2) TLX3 HOX11L2 Homo sapiens (Human) animal organ development [GO:0048513]; central nervous system development [GO:0007417]; GABAergic neuron differentiation [GO:0097154]; negative regulation of neuron differentiation [GO:0045665]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" YLASAER 1 2.4 0.91107 -0.32569 0 0 6.37041 0 0 0 0 0 0 0 0 0 O43719 HTSF1_HUMAN 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) HTATSF1 Homo sapiens (Human) "double-strand break repair via homologous recombination [GO:0000724]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to site of double-strand break [GO:1990166]; U2-type prespliceosome assembly [GO:1903241]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] chromatin-protein adaptor activity [GO:0140463]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; RNA binding [GO:0003723] ESDEDCSEKQSEDGSER;SDSVSASER;VFDDESDEK 3 4.6 0.95811 -1.0157 0 0 0 7.28873 7.29232 5.83165 0 7.05452 6.33735 7.70266 5.9977 0 O43734 CIKS_HUMAN E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; leukocyte activation involved in inflammatory response [GO:0002269]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; neutrophil activation [GO:0042119]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to P-body [GO:0110012]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634] signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630] NILLRLLREEEYVAPPR 1 3 0.53555 0.18628 0 0 10.7162 0 0 0 0 0 0 0 0 0 O43739 CYH3_HUMAN "Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)" CYTH3 ARNO3 GRP1 PSCD3 Homo sapiens (Human) establishment of epithelial cell polarity [GO:0090162]; Golgi vesicle transport [GO:0048193]; positive regulation of cell adhesion [GO:0045785]; regulation of ARF protein signal transduction [GO:0032012] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" ELIDDIER 1 2 0.91771 -0.42071 0 0 3.51046 0 0 0 11.2701 0 0 0 0 0 O43747 AP1G1_HUMAN AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) AP1G1 ADTG CLAPG1 Homo sapiens (Human) basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267] EEDNTYRCR;LSTRFTCTVNR;VLAINILGRFLLNNDK 3 4.4 0.96447 -1.1519 0 0 6.36587 0 5.84982 0 0 0 0 0 8.24907 0 O43749 OR1F1_HUMAN Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4) OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GALKKVVGR 1 2.9 0.83263 -0.027913 0 0 3.51488 0 0 0 0 0 0 0 0 0 O43760 SNG2_HUMAN Synaptogyrin-2 (Cellugyrin) SYNGR2 UNQ352/PRO615 Homo sapiens (Human) regulated exocytosis [GO:0045055]; synaptic vesicle membrane organization [GO:0048499] extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672] DVLVGADSVR 1 4.5 0.74511 0.090634 0 0 11.6974 0 0 0 0 0 0 0 0 0 O43765 SGTA_HUMAN Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) SGTA SGT SGT1 Homo sapiens (Human) ERAD pathway [GO:0036503]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; TRC complex [GO:0072380] BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] AICIDPAYSK;MGLALSSLNK;SPARTPPSEEDSAEAERLK 3 12.5 0.96381 -1.1857 0 0 0 0 6.02735 0 12.7528 0 0 0 0 0 O43766 LIAS_HUMAN "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" LIAS LAS HUSSY-01 Homo sapiens (Human) inflammatory response [GO:0006954]; lipoate biosynthetic process [GO:0009107]; neural tube closure [GO:0001843]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]; metal ion binding [GO:0046872]" VQPDVISKTSIMLGLGENDEQVYATMK 1 7.3 0.92857 -0.46347 0 0 0 8.18398 0 0 0 0 5.17069 0 0 0 O43772 MCAT_HUMAN Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (Solute carrier family 25 member 20) SLC25A20 CAC CACT Homo sapiens (Human) carnitine shuttle [GO:0006853]; carnitine transmembrane transport [GO:1902603]; in utero embryonic development [GO:0001701]; mitochondrial transport [GO:0006839] cytosol [GO:0005829]; mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] acyl carnitine transmembrane transporter activity [GO:0015227] LQTQPPSLPGQPPMYSGTFDCFRKTLFR;VSELSAPR 2 12 0.90966 -0.30056 0 0 0 0 0 6.21845 0 0 0 0 0 0 O43791 SPOP_HUMAN Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) SPOP Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of proteolysis [GO:0030162] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625] VNPKGLDEESK 1 2.9 0.96887 -1.3313 0 12.7957 0 0 0 0 0 0 0 0 0 0 O43795 MYO1B_HUMAN Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) MYO1B Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; post-Golgi vesicle-mediated transport [GO:0006892] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; brush border [GO:0005903]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; microvillus [GO:0005902]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" FLNDTSLPHSCFRIQHYAGK;ILRELKHQK;LYRTTLSQTK;SLFPEGNPAK;SLRDQDK 5 4.9 0.97559 -3.5829 0 13.9531 0 0 0 0 0 11.0121 0 0 8.22444 0 O43805 SSNA1_HUMAN Microtubule nucleation factor SSNA1 (Nuclear autoantigen of 14 kDa) (Sjoegren syndrome nuclear autoantigen 1) SSNA1 NA14 Homo sapiens (Human) axon arborization [GO:0140060]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell division [GO:0051301]; intraciliary transport [GO:0042073]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; receptor clustering [GO:0043113] axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; midbody [GO:0030496]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; supramolecular fiber [GO:0099512] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] IASRNEFDR;LARVNENLAR;REAGNLTKATAPDQK 3 28.6 0.96641 -1.2725 0 0 0 0 0 8.47496 0 0 0 0 0 8.8107 O43808 PM34_HUMAN Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17) SLC25A17 PMP34 Homo sapiens (Human) ATP transport [GO:0015867]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]; nucleotide transmembrane transport [GO:1901679] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; antiporter activity [GO:0015297]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; NAD transmembrane transporter activity [GO:0051724]; protein-folding chaperone binding [GO:0051087] AIATTVTYPLQTVQSILR 1 5.9 0.86461 -0.085779 0 0 0 0 0 0 9.01962 0 0 0 0 0 O43809 CPSF5_HUMAN Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) NUDT21 CFIM25 CPSF25 CPSF5 Homo sapiens (Human) "cell differentiation [GO:0030154]; co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of pro-B cell differentiation [GO:2000975]; positive regulation of stem cell differentiation [GO:2000738]; post-transcriptional regulation of gene expression [GO:0010608]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] GVTQFGNK;YIQQTKPLTLER 2 8.8 0.75319 0.076681 0 0 0 6.49357 7.34829 0 11.8877 0 0 0 0 0 O43813 LANC1_HUMAN Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) LANCL1 GPR69A Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cellular detoxification [GO:1990748]; G protein-coupled receptor signaling pathway [GO:0007186]; peptide modification [GO:0031179] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; low-density lipoprotein particle receptor binding [GO:0050750]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270] LTPEFSQR 1 2 0.88214 -0.15861 0 0 0 0 0 0 0 0 0 0 11.3987 0 O43815 STRN_HUMAN Striatin STRN Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; dendrite development [GO:0016358]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; nuclear estrogen receptor binding [GO:0030331]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877] ALLGFSSDVTDR;ALPDSGEDR;LPEHEINR;LQDMLANLR;RPNRSKLQDMLANLR;TWNPKFTLR 6 6.8 0.97835 -1.5312 0 0 0 11.5851 8.44948 0 0 0 9.24586 0 10.5143 0 O43820 HYAL3_HUMAN Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3) HYAL3 LUCA3 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle atresia [GO:0001552]; penetration of zona pellucida [GO:0007341]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; response to antibiotic [GO:0046677]; response to virus [GO:0009615] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415] HPLPVLAYVRLTHR 1 10.1 0.92156 -0.44571 0 0 0 0 0 0 0 9.39427 0 0 0 0 O43823 AKAP8_HUMAN A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) AKAP8 AKAP95 Homo sapiens (Human) cell cycle G2/M phase transition [GO:0044839]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; negative regulation of tumor necrosis factor production [GO:0032720]; protein transport [GO:0015031]; signal transduction [GO:0007165] condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] FRSFDDEEIQKHLQSK;LAAEQFK;RRQELMEK 3 4.5 0.95442 -0.80092 0 0 0 0 0 0 11.4251 0 11.0517 0 0 0 O43824 GTPB6_HUMAN Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like) GTPBP6 PGPL Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022] DVAHLYR;KALDRLR;SPGNLEGPWGGGR 3 5.2 0.95656 -0.9925 0 0 0 0 0 0 10.4735 7.5472 0 0 0 0 O43826 G6PT1_HUMAN Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19) SLC37A4 G6PT G6PT1 PRO0685 TRG19 Homo sapiens (Human) gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucose 6-phosphate:phosphate antiporter activity [GO:0061513]; glucose-6-phosphate transmembrane transporter activity [GO:0015152] HGLLLFMMAGMTVSMYLFR 1 4.4 0.86906 -0.096708 0 0 0 0 0 0 0 0 0 0 0 10.5075 O43827 ANGL7_HUMAN Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) blood coagulation [GO:0007596]; negative regulation of vasculature development involved in avascular cornea development in camera-type eye [GO:1901346]; regulation of extracellular matrix organization [GO:1903053]; response to oxidative stress [GO:0006979] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] identical protein binding [GO:0042802] RKSGLVSFYR 1 2.9 0.96631 -1.2624 0 0 0 0 0 11.718 0 0 0 0 13.9094 0 O43829 ZBT14_HUMAN Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) ZBTB14 ZFP161 ZNF478 Homo sapiens (Human) cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; kidney development [GO:0001822]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ELGSEEVRK 1 2 0.78271 0.030926 0 0 0 9.7067 0 0 0 0 0 0 0 0 O43837 IDH3B_HUMAN "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)" IDH3B Homo sapiens (Human) isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] isocitrate dehydrogenase complex (NAD+) [GO:0045242]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] electron transfer activity [GO:0009055]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] VAIIGKIHTPMEYK 1 3.6 0.88939 -0.20553 0 0 6.67271 0 7.01246 0 0 6.60352 0 7.81346 0 0 O43847 NRDC_HUMAN Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) NRDC NRD1 Homo sapiens (Human) negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548] cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759] epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ALNKGDANSEVTVYYQSGTR;LPLLFQLIIDYLAEFNSTPAVFTMITEQLKK;TVFQFDVQR 3 5.2 0.95293 -0.761 8.00113 7.2318 0 0 0 0 0 0 0 3.77915 10.0407 7.63096 O43854 EDIL3_HUMAN EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) cell adhesion [GO:0007155]; positive regulation of cell-substrate adhesion [GO:0010811] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561] calcium ion binding [GO:0005509]; integrin binding [GO:0005178] ARLDKQGK;LYPQVCR;LYPQVCRR;SGHIQDYQITASSIFRTLNMDMFTWEPRK;TLNMDMFTWEPR 5 9.4 0.97489 -4.1148 0 0 10.2054 9.79453 0 9.35619 0 0 0 0 0 0 O43861 ATP9B_HUMAN Probable phospholipid-transporting ATPase IIB (EC 7.6.2.1) (ATPase class II type 9B) ATP9B ATPIIB NEO1L HUSSY-20 Homo sapiens (Human) "endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] LETATCIAKSSHLVSR;LSPPSYCK;QVTSRGEAHLELNAFR 3 3.5 0.96395 -1.1111 12.4741 0 6.86084 0 0 0 0 0 0 0 0 0 O43865 SAHH2_HUMAN S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) AHCYL1 DCAL IRBIT XPVKONA Homo sapiens (Human) angiotensin-activated signaling pathway [GO:0038166]; apoptotic process [GO:0006915]; epithelial fluid transport [GO:0042045]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; one-carbon metabolic process [GO:0006730]; positive regulation of sodium ion transport [GO:0010765]; protein export from nucleus [GO:0006611]; regulation of monoatomic anion transport [GO:0044070]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of mRNA 3'-end processing [GO:0031440]; response to calcium ion [GO:0051592]; S-adenosylmethionine cycle [GO:0033353] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] FDNLYCCR;SMPDAMPLPGVGEELK;VRSQVDHVIWPDGK;YLGLNKNGPFKPNYYRY 4 10.4 0.88584 -0.19669 0 0 6.4552 0 0 0 7.416 0 0 7.2914 0 0 O43866 CD5L_HUMAN CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha) CD5L API6 UNQ203/PRO229 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; positive regulation of complement-dependent cytotoxicity [GO:1903661]; regulation of complement activation [GO:0030449]; zymogen activation [GO:0031638] blood microparticle [GO:0072562]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] NTCNHDEDTWVECEDPFDLR;QLGCGKSLSPSFRDR 2 10.1 0.32802 0.24461 0 0 0 0 0 4.45213 8.31836 0 0 0 0 0 O43868 S28A2_HUMAN Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2) SLC28A2 CNT2 Homo sapiens (Human) adenosine transport [GO:0032238]; azole transmembrane transport [GO:0045117]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; transport across blood-brain barrier [GO:0150104]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apicolateral plasma membrane [GO:0016327]; brush border membrane [GO:0031526]; coated vesicle [GO:0030135]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] azole transmembrane transporter activity [GO:1901474]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] CLKPFENSR 1 1.4 0.8485 -0.066675 0 0 0 0 0 0 0 0 7.90959 0 0 0 O43889 CREB3_HUMAN Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] CREB3 LZIP Homo sapiens (Human) chemotaxis [GO:0006935]; cytoplasmic sequestering of transcription factor [GO:0042994]; DNA-templated transcription [GO:0006351]; endoplasmic reticulum unfolded protein response [GO:0030968]; establishment of viral latency [GO:0019043]; induction of positive chemotaxis [GO:0050930]; integrated stress response signaling [GO:0140467]; negative regulation of cell cycle [GO:0045786]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "cAMP response element binding protein binding [GO:0008140]; CCR1 chemokine receptor binding [GO:0031726]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]" VQLLEEQNLSLLDQLRK 1 4.6 0.32648 0.2452 0 0 0 0 0 0 0 0 7.64587 0 0 0 O43895 XPP2_HUMAN Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2) XPNPEP2 Homo sapiens (Human) proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] ASHVRDAVAVIRYLVWLEK 1 2.8 0.49442 0.1893 0 0 0 0 10.9159 0 0 0 0 0 0 0 O43896 KIF1C_HUMAN Kinesin-like protein KIF1C KIF1C KIAA0706 Homo sapiens (Human) "anterograde neuronal dense core vesicle transport [GO:1990048]; retrograde neuronal dense core vesicle transport [GO:1990049]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]" axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; RNA binding [GO:0003723] NSLDGGGRSRGAGSAQPEPQHFQPK;RVYQIPQR;SCEESWR;VSRLMEEDPAFR;VYQIPQR;YPPYTTPPRMR 6 5.7 0.97523 -4.0962 7.64198 3.00189 0 10.214 0 0 6.97235 0 0 0 0 10.2567 O43897 TLL1_HUMAN Tolloid-like protein 1 (EC 3.4.24.-) TLL1 TLL Homo sapiens (Human) cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; protein processing [GO:0016485]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] DNGGCQHECVNTMGSYMCQCR;HDNCAYDYLEVR;LCGNKIPDPLVATGNKMFVR;VSVTPGEKIVLNFTTMDLYK 4 7.2 0.8866 -0.19246 0 6.32121 8.11671 0 0 0 0 7.85904 4.43503 10.9893 10.6022 0 O43900 PRIC3_HUMAN Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) PRICKLE3 LMO6 Homo sapiens (Human) cell projection organization [GO:0030030] mitochondrion [GO:0005739]; plasma membrane [GO:0005886] zinc ion binding [GO:0008270] ACSLGSEPTAPGPSRR;CFCCSRCGR 2 4.1 0.86469 -0.085253 8.61817 0 0 0 0 0 0 0 0 0 0 0 O43903 GAS2_HUMAN Growth arrest-specific protein 2 (GAS-2) GAS2 Homo sapiens (Human) actin crosslink formation [GO:0051764]; antral ovarian follicle growth [GO:0001547]; apoptotic process [GO:0006915]; basement membrane organization [GO:0071711]; initiation of primordial ovarian follicle growth [GO:0001544]; ovulation [GO:0030728]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593] actin filament [GO:0005884]; cytosol [GO:0005829]; membrane [GO:0016020]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; microtubule binding [GO:0008017] EIEQEETLSAPSPSPSPSSK;EVCLCLLELGR;IAARYGVEPPGLIKLEK;TSPIQSK 4 17.6 0.94455 -0.63749 0 0 8.80012 0 0 0 0 0 10.5967 6.13465 0 0 O43908 NKG2F_HUMAN NKG2-F type II integral membrane protein (NK cell receptor F) (NKG2-F-activating NK receptor) KLRC4 NKG2F Homo sapiens (Human) positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] GLLPPPEK 1 5.1 0.93671 -0.55019 0 10.3581 10.5389 0 0 0 0 0 0 0 8.65464 0 O43909 EXTL3_HUMAN Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell growth [GO:0030307]; positive regulation of detection of glucose [GO:2000972]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886] glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glycosyltransferase activity [GO:0016757]; magnesium ion binding [GO:0000287]; protein-hormone receptor activity [GO:0016500] IVGFPGR;VGNELCEVKHVLDLCR;VWREARDR 3 3.4 0.97638 -2.1983 0 0 0 0 0 0 10.5077 0 0 4.61789 0 6.67469 O43913 ORC5_HUMAN Origin recognition complex subunit 5 ORC5 ORC5L Homo sapiens (Human) DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166] AMQTVYLR;MPHLENVVLCRESQVSILQSLFGER 2 7.6 0.95186 -0.70262 0 0 7.51665 0 0 0 0 0 0 0 0 0 O43914 TYOBP_HUMAN TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein) TYROBP DAP12 KARAP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; amyloid-beta clearance [GO:0097242]; apoptotic cell clearance [GO:0043277]; cellular defense response [GO:0006968]; cellular response to amyloid-beta [GO:1904646]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; microglial cell activation involved in immune response [GO:0002282]; myeloid leukocyte activation [GO:0002274]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of type I interferon production [GO:0032480]; neutrophil activation involved in immune response [GO:0002283]; osteoclast differentiation [GO:0030316]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of osteoclast development [GO:2001206]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of tumor necrosis factor production [GO:0032760]; protein stabilization [GO:0050821]; response to axon injury [GO:0048678]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stimulatory killer cell immunoglobulin-like receptor signaling pathway [GO:0002222]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102] GAAEATR 1 6.2 0.61052 0.17485 0 0 0 0 0 0 0 0 0 8.72052 0 0 O43915 VEGFD_HUMAN Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) VEGFD FIGF Homo sapiens (Human) dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell chemotaxis [GO:0060754]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172] NCSCFECK;NCSCFECKESLETCCQKHK;SIQIPEEDRCSHSK;VIDEEWQR 4 11.6 0.87613 -0.12532 7.91367 9.20462 0 7.27631 0 0 0 5.13779 8.17483 11.9803 0 10.6213 O43916 CHST1_HUMAN Carbohydrate sulfotransferase 1 (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) (EC 2.8.2.21) CHST1 Homo sapiens (Human) galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790] Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] SPADRRVMLGASR;WIQNNTR 2 4.9 0.89974 -0.25845 0 10.6889 0 0 0 0 0 0 0 9.68863 0 0 O43921 EFNA2_HUMAN Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L) EFNA2 EPLG6 LERK6 Homo sapiens (Human) axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316] neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875] APAQRPLLPLLLLLLPLPPPPFAR 1 11.3 0.80653 0.0084121 0 0 0 0 0 0 0 0 0 0 0 3.45904 O43927 CXL13_HUMAN C-X-C motif chemokine 13 (Angie) (B cell-attracting chemokine 1) (BCA-1) (B lymphocyte chemoattractant) (CXC chemokine BLC) (Small-inducible cytokine B13) CXCL13 BCA1 BLC SCYB13 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; B cell chemotaxis [GO:0035754]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; endothelial cell chemotaxis to fibroblast growth factor [GO:0035768]; germinal center formation [GO:0002467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis across high endothelial venule [GO:0002518]; negative regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000545]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of integrin activation [GO:0033625]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of angiogenesis [GO:0045765]; regulation of humoral immune response [GO:0002920] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; CXCR5 chemokine receptor binding [GO:0031724]; fibroblast growth factor binding [GO:0017134]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018] CVQESSVFIPRR;EIIVWKK 2 17.4 0.17348 0.34117 0 0 0 0 4.03184 0 0 0 0 0 7.67828 0 O43930 PRKY_HUMAN Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) PRKY Homo sapiens (Human) cell adhesion [GO:0007155]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LFWTWHEER;LYFPRHLDFHVK 2 7.6 0.95878 -1.0064 0 0 0 0 0 0 0 0 0 8.32333 0 0 O43934 MFS11_HUMAN UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) MFSD11 ET Homo sapiens (Human) membrane [GO:0016020] TVFIALTVISLVGTVLFFLIR 1 4.7 0.65472 0.16939 0 0 0 0 0 0 4.32409 0 0 0 0 0 O60216 RAD21_HUMAN Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] RAD21 HR21 KIAA0078 NXP1 SCC1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription by RNA polymerase II [GO:0006357]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hypoxia [GO:0001666]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic cohesin complex [GO:0030892]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]" chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222] EKEDDEEEEDEDASGGDQDQEER;EKEKEDDEEEEDEDASGGDQDQEER;VEEITMR 3 5.1 0.91777 -0.40617 0 0 0 0 0 0 0 9.08071 6.96405 0 5.50808 4.39534 O60218 AK1BA_HUMAN Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) cellular detoxification of aldehyde [GO:0110095]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523] cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764] alcohol dehydrogenase (NADP+) activity [GO:0008106]; aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; allyl-alcohol dehydrogenase activity [GO:0047655]; geranylgeranyl reductase activity [GO:0045550]; indanol dehydrogenase activity [GO:0047718]; retinal dehydrogenase activity [GO:0001758] IVENIQVFDFK;LLNKPGLK;MPIVGLGTWK;NVIVIPK;VAIDAGYR 5 13.9 0 7.069 0 0 0 0 0 0 0 12.5777 0 0 0 13.5103 O60225 SSX5_HUMAN Protein SSX5 SSX5 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] MNGDDAFVR;VGSQIPEKMQK 2 10.6 0.95254 -0.76628 0 0 0 0 0 0 0 0 9.88736 0 0 0 O60229 KALRN_HUMAN Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AVELMCLVPKRCNDMMNLGR;GVPEDMR;HLEQKEAFLKACTLAR;ITSLLDK;LDQCQQYVVFERSAK;LLQCIRCSDGFSGR;LSLEEFFNSAVHLLSRLEDLQEMLAR;NIREVIQERIIHLK;VFLFEQIVIFSELLRKGSLTPGYMFK 9 4.9 0.85518 -0.080595 9.67992 0 0 0 10.2823 11.3066 0 0 4.85967 5.2604 10.2363 0 O60231 DHX16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) DHX16 DBP2 DDX16 KIAA0577 PRP2 Homo sapiens (Human) "antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; molecular adaptor activity [GO:0060090]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; ubiquitin binding [GO:0043130] ARDVREQLEGLLER;KVVVATNIAETSLTIEGIIYVLDPGFCK;TTQIPQYLFEEGYTNKGMK;VAAMSVAAR 4 6.7 0.97573 -2.3117 10.3565 0 0 0 0 0 3.99132 0 0 0 8.203 0 O60234 GMFG_HUMAN Glia maturation factor gamma (GMF-gamma) GMFG Homo sapiens (Human) actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; protein phosphorylation [GO:0006468] cortical actin cytoskeleton [GO:0030864]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860] LVQTAELTK;SDSLVVCEVDPELTEKLR 2 19 0.8293 -0.023707 0 0 0 0 0 0 0 0 9.89747 0 0 0 O60235 TM11D_HUMAN Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] TMPRSS11D HAT Homo sapiens (Human) proteolysis [GO:0006508]; respiratory gaseous exchange by respiratory system [GO:0007585] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] QDGSGVRADVVMK 1 3.1 0.88749 -0.18325 0 0 0 0 0 0 0 0 0 0 9.02206 0 O60237 MYPT2_HUMAN Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) PPP1R12B MYPT2 Homo sapiens (Human) neuron projection morphogenesis [GO:0048812]; regulation of muscle contraction [GO:0006937]; signal transduction [GO:0007165] A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725]; Z disc [GO:0030018] enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein kinase binding [GO:0019901] AEQLRRWR;AESARMRR;DLLLEQVK;GAGRQPLTR;MSEMEEEMK;SSVLEMEKRER 6 5.4 0.97641 -4.6719 10.1227 13.2884 13.3899 0 0 0 6.00198 9.50871 0 0 8.2447 0 O60238 BNI3L_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) BNIP3L BNIP3A BNIP3H NIX Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; defense response to virus [GO:0051607]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of programmed cell death [GO:0043069]; positive regulation of apoptotic process [GO:0043065]; positive regulation of macroautophagy [GO:0016239]; regulation of mitophagy [GO:1901524]; regulation of programmed cell death [GO:0043067]; regulation of protein targeting to mitochondrion [GO:1903214] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleus [GO:0005634] identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803] SVSLSMRK 1 3.7 0.92592 -0.45208 0 0 0 0 0 0 0 0 0 0 9.04004 0 O60240 PLIN1_HUMAN Perilipin-1 (Lipid droplet-associated protein) PLIN1 PERI PLIN Homo sapiens (Human) cellular response to cold [GO:0070417]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] lipid binding [GO:0008289] LSLMEPESEFR 1 2.1 0.79122 0.016745 0 0 0 0 4.21994 0 0 0 0 0 0 0 O60241 AGRB2_HUMAN Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2) ADGRB2 BAI2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; peripheral nervous system development [GO:0007422] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CQMGVCRADESEDSPDSCK;MLAGEGMSQVVRSLQELLAR;QVPEPGER;SCGRGSR;YLYLSLR 5 3.8 0.97411 -3.8076 0 0 10.3242 0 0 0 0 12.1756 4.50951 0 9.01876 0 O60242 AGRB3_HUMAN Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) ADGRB3 BAI3 KIAA0550 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814]; regulation of synapse maturation [GO:0090128]; regulation of synapse pruning [GO:1905806] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; synaptic cleft [GO:0043083] G protein-coupled receptor activity [GO:0004930]; GTPase activator activity [GO:0005096] AGQMSEPHSGLTLKCAK;EAKRPPK;NSEDRVVIPK;RHMELFQELNQKFQTLDR;TVLTDASHTK;VVIPKSIFTPVSSK 6 4.7 0.97601 -4.5173 0 0 12.9929 11.9939 12.2554 0 0 0 0 0 13.4934 0 O60243 H6ST1_HUMAN Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST-1) (EC 2.8.2.-) HS6ST1 HS6ST Homo sapiens (Human) "angiogenesis [GO:0001525]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; labyrinthine layer blood vessel development [GO:0060716]; lung alveolus development [GO:0048286]; neuron development [GO:0048666]" Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; sulfotransferase activity [GO:0008146] YQYKRQLER 1 2.2 0.82914 -0.025264 0 0 8.56777 0 0 0 0 0 0 0 0 0 O60244 MED14_HUMAN Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] VAGPPFK;VEKCAMISSFLDQQAILFVDTADR;VTPENAGQWKPDELQVLEK 3 3.4 0.90752 -0.30524 0 12.4945 0 0 10.1047 10.0926 11.8723 12.8461 12.044 3.87784 9.39451 0 O60245 PCDH7_HUMAN Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) PCDH7 BHPCDH Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] calcium ion binding [GO:0005509] FTVMARDR;GALDREQRDSYELTLR;LDETSGWLSVLHRIDR;LSIVIGVVAGIMTVILIILIVVMAR;QRLSIVIGVVAGIMTVILIILIVVMARYCR 5 6.5 0.95923 -1.0385 0 0 0 0 0 7.61515 8.60051 0 0 6.95617 0 0 O60248 SOX15_HUMAN Transcription factor SOX-15 (Protein SOX-12) (Protein SOX-20) (SRY-box transcription factor 15) SOX15 SOX12 SOX20 SOX26 SOX27 Homo sapiens (Human) brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; male gonad development [GO:0008584]; myoblast development [GO:0048627]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue regeneration [GO:0043403]; trophoblast giant cell differentiation [GO:0060707] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HLRDYPDYKYRPR 1 5.6 0.86907 -0.094003 0 0 0 0 0 0 0 0 0 5.47894 0 0 O60256 KPRB_HUMAN Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) PRPSAP2 Homo sapiens (Human) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; bone development [GO:0060348]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737] enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] SIIGVIPYFPYSK 1 3.5 0.87425 -0.11798 0 0 0 9.94166 0 0 0 0 0 0 0 0 O60258 FGF17_HUMAN Fibroblast growth factor 17 (FGF-17) FGF17 UNQ161/PRO187 Homo sapiens (Human) cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105]; type 2 fibroblast growth factor receptor binding [GO:0005111] GAESEKYICMNK;TRRPQPLT 2 9.3 0.98031 -1.8162 0 0 0 0 0 0 9.03659 0 0 0 0 0 O60260 PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) PRKN PARK2 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; amyloid fibril formation [GO:1990000]; autophagy of mitochondrion [GO:0000422]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; cellular response to unfolded protein [GO:0034620]; central nervous system development [GO:0007417]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; ERAD pathway [GO:0036503]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; macroautophagy [GO:0016236]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of primary amine oxidase activity [GO:1902283]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy [GO:1901526]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type 2 mitophagy [GO:1905091]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein deubiquitination [GO:0016579]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid transport [GO:0032368]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of necroptotic process [GO:0060544]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle transport [GO:1902803]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process [GO:0006511]" aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Lewy body [GO:0097413]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270] LEWCWNCGCEWNR;NGGCMHMK;NITCITCTDVR;WEAASKETIK 4 9 0.95555 -0.80681 0 0 6.42722 7.48067 0 0 0 0 0 0 7.94427 0 O60260 PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) PRKN PARK2 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; amyloid fibril formation [GO:1990000]; autophagy of mitochondrion [GO:0000422]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; cellular response to unfolded protein [GO:0034620]; central nervous system development [GO:0007417]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; ERAD pathway [GO:0036503]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; macroautophagy [GO:0016236]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of primary amine oxidase activity [GO:1902283]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy [GO:1901526]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type 2 mitophagy [GO:1905091]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein deubiquitination [GO:0016579]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid transport [GO:0032368]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of necroptotic process [GO:0060544]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle transport [GO:1902803]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process [GO:0006511]" aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Lewy body [GO:0097413]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270] GVAGCPNSLIK;NITCITCTDVR 2 5.7 0.89694 -0.23467 0 0 0 0 0 0 0 0 8.0359 0 0 0 O60264 SMCA5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) SMARCA5 SNF2H WCRF135 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; DNA-templated transcription initiation [GO:0006352]; heterochromatin formation [GO:0031507]; negative regulation of mitotic chromosome condensation [GO:1905213]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] ACF complex [GO:0016590]; B-WICH complex [GO:0110016]; CHRAC [GO:0008623]; chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; condensed chromosome [GO:0000793]; fibrillar center [GO:0001650]; NoRC complex [GO:0090536]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; pericentric heterochromatin [GO:0005721]; RSF complex [GO:0031213]; site of double-strand break [GO:0035861]; WICH complex [GO:0090535] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone octamer slider activity [GO:0140751]; nucleosome array spacer activity [GO:0140750]; nucleosome binding [GO:0031491] FDWFLKSR;FITDNTVEER;FNWRYLVIDEAHR;IAFTEWIEPPK;LGFDKENVYDELR;LVDQNLNK;QNLLSVGDYRHR;RTEQEEDEELLTESSK 8 8.7 0.97234 -2.8337 12.9606 0 0 9.34857 0 0 0 5.90012 9.60874 0 10.7047 0 O60266 ADCY3_HUMAN "Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)" ADCY3 KIAA0511 Homo sapiens (Human) acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338] ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] GLLPDRVTR;LLNELFAR;THEISVR 3 2.1 0.97503 -2.3739 0 0 0 0 0 0 0 12.2654 0 8.12856 0 0 O60271 JIP4_HUMAN C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) "lysosome localization [GO:0032418]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell migration [GO:0030335]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]" acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159] AEAEDARQKAK;ITALMVSCNR;NQYKERLMELQEAVR;NRELEEELR 4 3.4 0.91763 -0.40108 0 0 0 0 0 0 0 6.67087 9.78313 0 11.1772 0 O60281 ZN292_HUMAN Zinc finger protein 292 ZNF292 KIAA0530 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" AETQNTHSNVAVIPEKQLVEKK;AKCMFPK;DEMDELTELFITK;DGKFICSRCYR;FTGCGKVYR;GRGPNGK;QTYLVCLCTSSPNGKLIEEISEVDCK;RLGRPPK;TQWPFDPEFWDWKTLK;TVYHIFFLIK;VEPSIQVYLERCR 11 5.2 0.97175 -1.3537 4.48143 0 0 8.80764 8.95335 8.50577 0 9.21447 12.6704 3.64708 10.016 8.78588 O60282 KIF5C_HUMAN Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) KIF5C KIAA0531 NKHC2 Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; intracellular mRNA localization [GO:0008298]; motor neuron axon guidance [GO:0008045]; mRNA transport [GO:0051028]; organelle organization [GO:0006996]; synaptic vesicle transport [GO:0048489] axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; distal axon [GO:0150034]; GABA-ergic synapse [GO:0098982]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; postsynaptic cytosol [GO:0099524] apolipoprotein receptor binding [GO:0034190]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] ALESALK;DNADLRCELPK;EAVRAKNMAR;LLLLNDK;QLVRDNADLRCELPK;TGAEGAVLDEAK;YQQEVDR 7 6.1 0.33634 0.24128 0 0 0 7.56499 0 0 0 0 0 10.4047 0 0 O60284 ST18_HUMAN Suppression of tumorigenicity 18 protein (Zinc finger protein 387) ST18 KIAA0535 ZNF387 Homo sapiens (Human) interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; tumor necrosis factor-mediated signaling pathway [GO:0033209] chromatin [GO:0000785]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ADCQEDR;ADCQEDRSDR;CPTPGCTGRGHVNSNRNTHR;SLMHLGK;SLSGCPIAAAEK 5 4.7 0.91166 -0.32385 9.41287 9.94797 0 0 7.87086 0 0 8.18824 0 8.47216 10.1642 0 O60287 NPA1P_HUMAN Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" fibrillar center [GO:0001650]; nucleolus [GO:0005730] RNA binding [GO:0003723] AQEGPDAEIIGGER;SLGRSLWQQPSVGDILR;SLTKLLIMKILR;TEQKWVFGVLR;TLYTLVTKRDSK;YSEAITQSVLKELQNR 6 3.6 0.95477 -0.96135 0 0 0 0 0 5.51982 10.6311 4.0787 8.94084 0 5.69761 8.06862 O60290 ZN862_HUMAN Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] KEEMGALYVEEPR;LEVAEQRFQADR;SLLEHHPGK;TVFKFYQSSNKR 4 3.9 0.97319 -2.5615 0 0 0 0 5.52801 0 11.5353 0 0 0 10.5737 0 O60290 ZN862_HUMAN Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] KEEMGALYVEEPR;RWCEWTVLTGIEYLQQR 2 11.8 0.57887 0.18024 0 0 0 0 0 0 0 0 0 0 6.82235 0 O60291 MGRN1_HUMAN E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) MGRN1 KIAA0544 RNF156 Homo sapiens (Human) endosome to lysosome transport [GO:0008333]; heart development [GO:0007507]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of smoothened signaling pathway [GO:0045879]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] MGSILSR 1 1.3 0.90877 -0.31607 0 0 0 0 0 0 0 0 0 0 7.8874 0 O60292 SI1L3_HUMAN Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) SIPA1L3 KIAA0545 SPAL3 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; eye development [GO:0001654]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of small GTPase mediated signal transduction [GO:0051056] "apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]; stress fiber [GO:0001725]; tricellular tight junction [GO:0061689]" GTPase activator activity [GO:0005096] LEDHKEHGPQYQYR;QLHTDLQKEK;SKDVEFQDGWPR 3 2 0.9743 -2.4463 0 7.28438 0 5.11757 0 0 6.7786 0 5.45796 8.48667 0 4.62743 O60293 ZC3H1_HUMAN Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) ZFC3H1 CCDC131 KIAA0546 PSRC2 Homo sapiens (Human) RNA processing [GO:0006396] exosome (RNase complex) [GO:0000178]; extracellular space [GO:0005615]; nuclear exosome (RNase complex) [GO:0000176]; nucleus [GO:0005634] metal ion binding [GO:0046872] KFIASFFKPGFEKYNNLDLFR;KIRDLSNQEEQYNR;LLQHEWEESNVQILK;MPSSSLSESSPRPSFWER;NLVQQEAK;SPSRKQNYSSK;VIFFYLSCVPK;VTIKKALTLK;YGEELARAK 9 5.9 0.97654 -2.1812 0 7.56712 6.3544 8.85087 10.0132 0 0 12.6728 11.2833 0 6.86009 0 O60296 TRAK2_HUMAN Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) TRAK2 ALS2CR3 KIAA0549 Homo sapiens (Human) anterograde axonal transport of mitochondrion [GO:0098957]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] LSIGESITNR;SISFPALLPIPGSNR 2 2.7 0.93984 -0.57991 4.15372 0 0 0 0 0 0 0 0 0 0 0 O60299 LZTS3_HUMAN Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1) LZTS3 KIAA0552 PROSAPIP1 Homo sapiens (Human) regulation of dendritic spine morphogenesis [GO:0061001] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; synapse [GO:0045202] LSEIVGLRSQLR 1 1.8 0.88693 -0.18481 0 10.6996 0 0 0 0 0 0 0 0 0 0 O60303 KATIP_HUMAN Katanin-interacting protein KATNIP KIAA0556 Homo sapiens (Human) cerebrospinal fluid circulation [GO:0090660] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615] AINQAMDRIGLLGSRQQQK;DIRHQEK;EQVSDTEDKQRMR;IHSFRGVK;RPSTADGEGDERPFTQAGLGADER 5 4.4 0.9797 -1.5472 0 0 7.89942 7.69377 7.65585 10.0207 0 0 0 8.54527 0 0 O60304 ZN500_HUMAN Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18) ZNF500 KIAA0557 ZKSCAN18 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSQSSSLVIHRRTHSGERPYACTQCGK 1 5.6 0.69377 0.16215 0 0 0 0 0 0 0 0 0 0 8.46976 0 O60306 AQR_HUMAN RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) AQR KIAA0560 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] AAPAQPK;HLIRDIINR;LVVAMSRAR;VIEDIYEK;VTVEDPALQIPPFRITFPVRSGK 5 3.8 0.97536 -4.2137 12.1417 0 0 13.3818 8.18215 8.09908 12.7903 12.0796 12.0106 9.83905 14.6945 10.6223 O60307 MAST3_HUMAN Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) MAST3 KIAA0561 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALVGQSRRKPCESDFETIK;GQSADKLGTGER;INKQNLILR;SPRLRPR 4 3.6 0.9805 -1.6114 0 9.67647 0 0 0 10.3501 0 0 9.41051 0 0 0 O60308 CE104_HUMAN Centrosomal protein of 104 kDa (Cep104) CEP104 KIAA0562 Homo sapiens (Human) centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] ATDAEMRARR;EIQAEVQEK;ETAVRIILDMYR;SSSRTYAKR 4 4.3 0.98045 -1.7971 0 0 0 0 0 0 0 11.6086 0 9.41481 9.58637 0 O60309 L37A3_HUMAN Leucine-rich repeat-containing protein 37A3 LRRC37A3 KIAA0563 Homo sapiens (Human) membrane [GO:0016020] DLTHAISILESAK;ELPGYGYTK;ELPGYGYTKK;LPVSPKKLK;SLINSPSQGAFSSLR 5 2.9 0.92886 -0.47177 0 0 0 0 0 0 8.54674 11.0969 9.20999 0 0 0 O60312 AT10A_HUMAN Phospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A) ATP10A ATP10C ATPVA ATPVC KIAA0566 Homo sapiens (Human) monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of membrane tubulation [GO:1903527]; regulation of cell shape [GO:0008360] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554] DSGTEHSSGRTVK;EEKKYVNR;LANMVLYFFYK;SLFYVPK;SPVKTIEDFLRR;VSECDKSLAVAR 6 4.2 0.97612 -5.2146 0 0 0 0 10.6444 10.5421 0 0 0 9.10198 9.06684 0 O60313 OPA1_HUMAN "Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)]" OPA1 KIAA0567 Homo sapiens (Human) apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; cellular senescence [GO:0090398]; cristae formation [GO:0042407]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrial inner membrane fusion [GO:1990627]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neural tube closure [GO:0001843]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; protein complex oligomerization [GO:0051259]; visual perception [GO:0007601] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase-dependent fusogenic activity [GO:0140523]; magnesium ion binding [GO:0000287]; membrane bending activity [GO:0180020]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300] ATDRGSESDKHFR;DTENAIENMVGPDWKK;HEIELRMRK;LHLVSRSIYHSHHPTLKLQRPQLR;VVVVGDQSAGK 5 7.6 0.25513 0.27234 0 0 0 0 0 0 6.49662 0 0 11.2782 9.85851 0 O60315 ZEB2_HUMAN Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411 Homo sapiens (Human) astrocyte activation [GO:0048143]; central nervous system development [GO:0007417]; developmental pigmentation [GO:0048066]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; fibroblast activation [GO:0072537]; melanocyte migration [GO:0097324]; myofibroblast differentiation [GO:0036446]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myofibroblast contraction [GO:1904330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pyroptotic inflammatory response [GO:0070269]; regulation of blood-brain barrier permeability [GO:1905603]; regulation of melanosome organization [GO:1903056]; regulation of myofibroblast cell apoptotic process [GO:1904520]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxygen-glucose deprivation [GO:0090649]; stress fiber assembly [GO:0043149] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; phosphatase regulator activity [GO:0019208]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SDHEEDNMEDGM 1 1 0.7116 0.15426 0 0 5.70429 7.57841 0 5.24869 0 0 0 0 0 0 O60318 GANP_HUMAN Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) MCM3AP GANP KIAA0572 MAP80 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nucleosome organization [GO:0034728]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; somatic hypermutation of immunoglobulin genes [GO:0016446] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390] chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nucleic acid binding [GO:0003676] DRIMRQAR;EQLQLSEATGTCLGERLK;LVLVLPDVEEQSPESCGR;NIPDYLNDR 4 2.7 0.97571 -2.3308 0 0 0 0 10.9157 9.70881 0 0 0 0 0 0 O60320 EREP2_HUMAN Protein ENTREP2 (Endosomal transmembrane epsin interactor 2) (Transmembrane protein 228) ENTREP2 FAM189A1 KIAA0574 TMEM228 Homo sapiens (Human) membrane [GO:0016020] LRECPGRSR 1 1.7 0.88302 -0.17168 0 3.56145 0 0 0 0 0 0 0 0 0 0 O60330 PCDGC_HUMAN Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3) PCDHGA12 CDH21 FIB3 KIAA0588 UNQ371/PRO707 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] YPELVLKR 1 0.9 0.92942 -0.48457 0 0 0 0 0 0 0 0 0 13.6332 0 0 O60331 PI51C_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) PIP5K1C KIAA0589 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079] adherens junction [GO:0005912]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742] QAQGAQSTSDEK 1 1.8 0.93714 -0.56764 0 0 9.93046 0 0 0 0 0 0 0 0 0 O60333 KIF1B_HUMAN Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) KIF1B KIAA0591 KIAA1448 Homo sapiens (Human) anterograde synaptic vesicle transport [GO:0048490]; apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; mitochondrion transport along microtubule [GO:0047497]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] ELATKCLQLLTHTFNR;LGDSIPK;QRLDLMREMYDR;SHAVFTIVFTQK;SLFGSGYSK 5 3.1 0.96344 -1.1065 9.54417 0 0 0 0 0 8.18686 0 0 0 9.64627 0 O60333 KIF1B_HUMAN Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) KIF1B KIAA0591 KIAA1448 Homo sapiens (Human) anterograde synaptic vesicle transport [GO:0048490]; apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; mitochondrion transport along microtubule [GO:0047497]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] ELCAMYGK;IEDVMATGK;SHAVFTIVFTQK;WVTISDLKIQAVK 4 3.6 0.97871 -1.9675 0 0 0 0 0 0 0 0 0 10.1156 0 0 O60341 KDM1A_HUMAN Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) KDM1A AOF2 KDM1 KIAA0601 LSD1 Homo sapiens (Human) "cellular response to cAMP [GO:0071320]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cerebral cortex development [GO:0021987]; DNA repair-dependent chromatin remodeling [GO:0140861]; epigenetic regulation of gene expression [GO:0040029]; guanine metabolic process [GO:0046098]; muscle cell development [GO:0055001]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation-coupled chromatin remodeling [GO:0160217]; neuron maturation [GO:0042551]; positive regulation of cell size [GO:0045793]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein demethylation [GO:0006482]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fungicide [GO:0060992]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA repair complex [GO:1990391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]" chromatin binding [GO:0003682]; demethylase activity [GO:0032451]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K9 demethylase activity [GO:0032454]; identical protein binding [GO:0042802]; MRF binding [GO:0043426]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; oxidoreductase activity [GO:0016491]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric repeat-containing RNA binding [GO:0061752]; transcription coactivator activity [GO:0003713] ELHQQYK;GELFLFWNLYK;TLQLWLDNPK 3 3.3 0.96459 -1.231 0 0 0 0 0 0 0 0 0 0 0 10.6855 O60343 TBCD4_HUMAN TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; negative regulation of vesicle fusion [GO:0031339]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982] GTPase activator activity [GO:0005096] EVLITWDKK;GEIWQFLALQYRLRHR;LLHDYHR;SLWRKAIHQQILLLR;VASPMNK 5 4.2 0.97504 -2.3784 0 0 7.83927 0 8.90986 0 10.7961 0 0 11.3942 0 0 O60347 TBC12_HUMAN TBC1 domain family member 12 TBC1D12 KIAA0608 Homo sapiens (Human) regulation of autophagosome assembly [GO:2000785] autophagosome [GO:0005776]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096] GAEVADGRAPR;GLARAGGRESR;NTFQVSR;SLPLDLACR 4 4.9 0.97494 -3.1878 0 11.1161 0 0 0 0 0 9.47656 0 0 0 9.7616 O60353 FZD6_HUMAN Frizzled-6 (Fz-6) (hFz6) FZD6 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; embryonic nail plate morphogenesis [GO:0035880]; establishment of body hair planar orientation [GO:0048105]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; platelet activation [GO:0030168]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] LREQDCGEPASPAASISRLSGEQVDGK;SDELEFAK 2 5 0.94154 -0.61285 0 0 0 7.455 0 0 11.0276 0 11.5046 0 0 0 O60359 CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3) CACNG3 Homo sapiens (Human) "calcium ion transport [GO:0006816]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of AMPA receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891] channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]; voltage-gated calcium channel activity [GO:0005245] DLSPISK;LPPYRYRFR 2 5.1 0.9373 -0.54056 0 0 11.207 0 0 0 0 9.02572 0 5.65343 0 0 O60381 HBP1_HUMAN HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) HBP1 Homo sapiens (Human) regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDHPFYVKNK;LNPDCWKRK;SLHSYARPPPVSSSSK 3 6.8 0.9138 -0.38096 0 9.08281 0 0 0 11.5192 0 0 0 0 0 0 O60383 GDF9_HUMAN Growth/differentiation factor 9 (GDF-9) GDF9 Homo sapiens (Human) female gamete generation [GO:0007292]; negative regulation of cell growth [GO:0030308]; oocyte growth [GO:0001555]; positive regulation of cell population proliferation [GO:0008284]; regulation of progesterone secretion [GO:2000870]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] LDSSVPRPSCVPAK;RGQETVSSELK 2 5.5 0.9582 -1.0156 0 0 0 0 0 0 0 0 10.1615 0 0 0 O60391 NMD3B_HUMAN "Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B)" GRIN3B Homo sapiens (Human) "ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; protein insertion into membrane [GO:0051205]; regulation of calcium ion transport [GO:0051924]; synaptic transmission, glutamatergic [GO:0035249]" neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; monoatomic cation channel activity [GO:0005261]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DPASLTR;LGALLPRAPLAR 2 1.8 0.81398 -0.0057372 0 0 0 0 0 0 7.14639 1.55031 0 0 0 0 O60393 NOBOX_HUMAN Homeobox protein NOBOX NOBOX Homo sapiens (Human) oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" ALLLTLTSPDLEGTWDTR;IMVWFQNRRAK;LIPLVSGK 3 5.6 0.92775 -0.45735 8.83826 0 9.12756 6.22672 0 0 0 0 0 0 0 0 O60397 COX7S_HUMAN "Putative cytochrome c oxidase subunit 7A3, mitochondrial (Cytochrome c oxidase subunit VIIa 3)" COX7A2P2 COX7A3 COX7AL2 COX7AP2 Homo sapiens (Human) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]" mitochondrial inner membrane [GO:0005743]; respiratory chain complex [GO:0098803]; respiratory chain complex IV [GO:0045277] LFQEDDGIPLYLK 1 12.3 0.6928 0.16229 0 0 5.5421 0 0 0 0 0 2.65411 0 0 0 O60427 FADS1_HUMAN Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) FADS1 FADSD5 Homo sapiens (Human) alpha-linolenic acid metabolic process [GO:0036109]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; icosanoid biosynthetic process [GO:0046456]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; phospholipid biosynthetic process [GO:0008654]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739] "acyl-CoA delta5-desaturase activity [GO:0062076]; C-5 sterol desaturase activity [GO:0000248]; linoleoyl-CoA desaturase activity [GO:0016213]; omega-6 fatty acid desaturase activity [GO:0045485]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" KVYNISEFTR;KVYNISEFTRR;VYNISEFTRRHPGGSR 3 3.8 0.38756 0.2147 0 12.2168 5.33949 0 0 0 0 0 0 0 0 9.97484 O60437 PEPL_HUMAN Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) PPL KIAA0568 Homo sapiens (Human) intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] AVQDSAER;EHALLRLQLEEEQHR;GYSYTLQK;KEIQALKDTKPQVQTK;LELVEQER;LTPAQYDR;QLLEGELETLR;QNLQLETR;VTHTQKVVLQQDPQQAR;YRGAEEQLR 10 6.2 0.97505 -3.3736 11.4118 6.20332 0 0 0 0 10.0997 10.5688 0 0 12.0802 0 O60443 GSDME_HUMAN "Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]" GSDME DFNA5 ICERE1 Homo sapiens (Human) cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inner ear auditory receptor cell differentiation [GO:0042491]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of immune response to tumor cell [GO:0002839]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of MAPK cascade [GO:0043410]; programmed cell death [GO:0012501]; pyroptotic cell death [GO:0141201]; pyroptotic inflammatory response [GO:0070269]; sensory perception of sound [GO:0007605] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] "cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; wide pore channel activity [GO:0022829]" EVDADGDLIAVSNLNDSDKLQLLSLVTKK;LDGQFEFCLLR 2 8.1 0.87024 -0.095912 8.10559 0 0 0 0 0 0 5.86297 0 0 0 0 O60447 EVI5_HUMAN Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) EVI5 NB4S Homo sapiens (Human) "cell division [GO:0051301]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]" centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle [GO:0005819] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] DIARTYPEHNFFKEK;DQYSELLKMTSPCEKLIR;EAEAIMGLK 3 5.2 0.91579 -0.33895 0 0 0 0 10.3504 0 0 0 0 15.6868 8.60862 8.03326 O60449 LY75_HUMAN Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) LY75 CD205 CLEC13B Homo sapiens (Human) endocytosis [GO:0006897]; immune response [GO:0006955]; inflammatory response [GO:0006954] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] CLGLDITK;KGNCEVSSVEGTLCK;LFHLHSQK;LNDASSDK;MFSCDSSAMLWWK;YLNNLYK;YLNNLYKIIPK 7 3.5 0.98077 -1.6357 5.77894 9.73001 16.324 5.46809 0 10.4277 11.0627 0 15.564 9.86192 9.87684 11.8274 O60469 DSCAM_HUMAN Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) DSCAM Homo sapiens (Human) axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782] ALGHPEPDYR;EPYTVRVEDQK;ISNLSLMHNGNYTCIAR;LYVKQPLKATISPR;SDSWDSAQR;VIYWANLMDGELGEIKNITTTQPSLELDGLEK;YTNYSIQVLAFTRAGDGVR 7 5.6 0.96422 -1.1994 0 10.0799 0 8.48977 0 8.97441 0 0 9.55474 0 9.70491 7.14995 O60477 BRNP1_HUMAN BMP/retinoic acid-inducible neural-specific protein 1 (Deleted in bladder cancer protein 1) BRINP1 DBC1 DBCCR1 FAM5A IB3089A Homo sapiens (Human) behavioral fear response [GO:0001662]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron development [GO:0021954]; central nervous system neuron differentiation [GO:0021953]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; homeostasis of number of cells within a tissue [GO:0048873]; maternal behavior [GO:0042711]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of neurogenesis [GO:0050768]; positive regulation of neuron differentiation [GO:0045666]; proteasomal protein catabolic process [GO:0010498]; protein stabilization [GO:0050821]; short-term memory [GO:0007614]; social behavior [GO:0035176]; vocalization behavior [GO:0071625] cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025] DLENSDEFK;MNWRFVELLYFLFIWGR;QGFTTRYKIYR;TIQQWLAR 4 5.9 0.97363 -2.6478 0 0 11.8756 0 0 0 0 9.55762 0 0 0 0 O60481 ZIC3_HUMAN Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3) ZIC3 ZNF203 Homo sapiens (Human) atrial cardiac muscle tissue development [GO:0003228]; axial mesoderm development [GO:0048318]; central nervous system development [GO:0007417]; central nervous system segmentation [GO:0035283]; cranial skeletal system development [GO:1904888]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; embryonic pattern specification [GO:0009880]; face development [GO:0060324]; germ-line stem cell population maintenance [GO:0030718]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; left/right axis specification [GO:0070986]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; neural plate development [GO:0001840]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]" WIDEAQLSRPKKSCDR 1 3.4 0.8499 -0.075669 0 0 0 0 0 0 0 0 10.1317 0 0 0 O60486 PLXC1_HUMAN Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) PLXNC1 VESPR Homo sapiens (Human) cell adhesion [GO:0007155]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of synapse pruning [GO:1905806]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154]; signaling receptor binding [GO:0005102] DVSVVNVMFSFGSWNLSDR;FNFTNCSSLK;FSLPSSR;GTSTCDK;LMLRRTESVVEK;LVPDPVK;RTESVVEK;VAIHSVLEK 8 4.5 0.9746 -3.915 0 0 0 14.5307 0 7.1981 0 0 0 9.60303 10.0749 11.6188 O60487 MPZL2_HUMAN Myelin protein zero-like protein 2 (Epithelial V-like antigen 1) MPZL2 EVA EVA1 UNQ606/PRO1192 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] YGKSSTR 1 3.3 0.90843 -0.27613 0 0 0 0 8.17547 0 0 0 0 0 0 0 O60488 ACSL4_HUMAN Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) ACSL4 ACS4 FACL4 LACS4 Homo sapiens (Human) embryonic process involved in female pregnancy [GO:0060136]; fatty acid metabolic process [GO:0006631]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; negative regulation of prostaglandin secretion [GO:0032307]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of insulin secretion [GO:0032024] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957] EILSEENEMQPNGKVFK;IGYSSPLTLSDQSSK;IPGLGPK;LILGNYKWMNYLEVNR;NAMAKRIK 5 8.9 0.9749 -2.397 11.4451 0 0 0 0 0 0 13.6857 6.60922 8.47021 8.07799 0 O60493 SNX3_HUMAN Sorting nexin-3 (Protein SDP3) SNX3 Homo sapiens (Human) endocytic recycling [GO:0032456]; intralumenal vesicle formation [GO:0070676]; late endosome to Golgi transport [GO:0034499]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; retromer complex [GO:0030904] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]; retromer complex binding [GO:1905394]" FTTYEIR;VVVPPLPGK 2 9.9 0.95368 -0.92107 0 0 7.79312 0 0 0 0 0 0 0 0 0 O60494 CUBN_HUMAN Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; tissue homeostasis [GO:0001894] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023] IAQLCTQR;ICEWRITAPEGR;LVDLERKFQGLQQTVDK;TDSFQTAK 4 1.2 0.97817 -2.1437 0 0 0 0 0 9.42255 0 0 0 0 7.70093 0 O60496 DOK2_HUMAN Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) DOK2 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] FGASLYGGSDCALARLELQEGPEKPR 1 6.3 0.92885 -0.46058 0 0 0 0 0 0 0 0 8.02065 0 0 0 O60499 STX10_HUMAN Syntaxin-10 (Syn10) STX10 SYN10 Homo sapiens (Human) "Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]" cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] LAKVSHMTSDR 1 4.4 0.97444 -1.4251 0 0 0 0 11.6558 0 0 0 0 0 0 0 O60500 NPHN_HUMAN Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) cell-cell adhesion [GO:0098609]; gene expression [GO:0010467]; glomerular basement membrane development [GO:0032836]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; podocyte development [GO:0072015]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; skeletal muscle tissue development [GO:0007519]; slit diaphragm assembly [GO:0036060] cell projection [GO:0042995]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057] cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022] GVPNIVFTWTK;LLRLVVR;TVTESRLPQESR 3 2.4 0.96178 -1.0708 0 0 0 0 10.0941 9.53164 0 0 0 0 0 0 O60502 OGA_HUMAN Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) OGA HEXC KIAA0679 MEA5 MGEA5 Homo sapiens (Human) glycoprotein catabolic process [GO:0006516]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517]; protein O-linked glycosylation [GO:0006493] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; beta-N-acetylglucosaminidase activity [GO:0016231]; hyalurononglucosaminidase activity [GO:0004415]; identical protein binding [GO:0042802] GAFCEVRPDDKRILEFYSK;ILEFYSKLGCFEIAK;QVAHSGAK;VYTIRPYFPK 4 4.9 0.98196 -1.5822 0 8.82142 0 4.25384 0 0 3.64016 0 0 6.55546 0 0 O60503 ADCY9_HUMAN Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) ADCY9 KIAA0520 Homo sapiens (Human) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] KEMVNMR;TCPSCGITFAPK;VGGGGRLRR 3 2.1 0.97964 -1.9957 0 0 0 0 0 0 8.42442 0 0 8.83851 0 0 O60506 HNRPQ_HUMAN "Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)" SYNCRIP HNRPQ NSAP1 Homo sapiens (Human) "cellular response to type II interferon [GO:0071346]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA modification [GO:0016556]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; CRD-mediated mRNA stability complex [GO:0070937]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; GAIT complex [GO:0097452]; histone pre-mRNA 3'end processing complex [GO:0071204]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] AGPIWDLR;DLFEDELVPLFEK;GVEAGPDLLQ;LFVGSIPK;NLANTVTEEILEK;NRGFCFLEYEDHK;QAAKNQMYDDYYYYGPPHMPPPTRGR;TGYTLDVTTGQR 8 18.3 0 7.9203 5.12743 0 0 11.3018 0 0 9.30088 0 0 8.75592 9.81988 0 O60507 TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) TPST1 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; post-translational protein modification [GO:0043687] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476] DCLTKWNR;SGTTLMR;VIPRILALK;WMRTLLK 4 8.4 0.97685 -4.7641 0 0 8.41971 0 0 0 11.4586 0 0 0 8.43646 0 O60508 PRP17_HUMAN Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) CDC40 EHB3 PRP17 PRPF17 Homo sapiens (Human) "embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U2-type catalytic step 2 spliceosome [GO:0071007] mRNA binding [GO:0003729]; RNA binding [GO:0003723] SGEIVQEYDR;TTKLYSRFK 2 3.3 0.96717 -1.2686 10.458 0 0 0 0 0 0 0 6.45376 0 0 0 O60518 RNBP6_HUMAN Ran-binding protein 6 (RanBP6) RANBP6 Homo sapiens (Human) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; synapse [GO:0045202] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] LACGLGGK;NQELRQVK;TTFLLDAVRNRR 3 2.5 0.98017 -1.5701 0 0 0 0 0 0 0 12.295 0 0 0 0 O60519 CRBL2_HUMAN cAMP-responsive element-binding protein-like 2 CREBL2 Homo sapiens (Human) cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; positive regulation of D-glucose import [GO:0046326]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AKLERSR 1 5.8 0.97409 -1.4126 0 0 0 0 0 0 10.9103 11.1616 11.0637 0 0 0 O60522 TDRD6_HUMAN Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2) TDRD6 Homo sapiens (Human) P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186] AIVTKLDDK;EMVSVKNIYSISEEFLKVK;KELVSCSSLR;LSESMAQVYR;LSNKAVQNKIYMEQQTDELAEITEK;LVDFGNIEDCVDPK;TGEGEQKAK;TLMSDIQYYCKNTAAPHQR;TVLHKELVIHILDKQDHQYVIEILDESR 9 6.8 0.97225 -2.7896 8.32057 8.44133 6.76924 0 0 6.75061 11.2694 7.24432 9.3745 0 0 13.8437 O60524 NEMF_HUMAN Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) NEMF SDCCAG1 Homo sapiens (Human) CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; RQC complex [GO:1990112] alpha-aminoacyl-tRNA binding [GO:1904678]; ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049] KQPQKPRGGQR;LLGSAGSNKEEKGK;LTPGVQKK;NVAAVQPMKR;QTLKEVQTVTSIQK;TVEAAEK 6 5.9 0.97654 -5.5178 0 0 0 0 0 11.2236 0 0 0 8.13206 0 0 O60542 PSPN_HUMAN Persephin (PSP) PSPN Homo sapiens (Human) central nervous system development [GO:0007417]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; nervous system development [GO:0007399] extracellular region [GO:0005576]; extracellular space [GO:0005615] glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] AGGTWLGTHRPLAR 1 9 0.78269 0.024449 0 0 0 8.57293 0 0 0 0 0 0 0 0 O60547 GMDS_HUMAN "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" GMDS Homo sapiens (Human) 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-L-fucose biosynthetic process [GO:0042350]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401]" AKQKLNWKPR 1 2.7 0.97495 -1.3823 0 0 0 0 0 9.17555 0 0 0 0 0 0 O60548 FOXD2_HUMAN Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead-related transcription factor 9) (FREAC-9) FOXD2 FKHL17 FREAC9 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" EPGNPGK 1 1.4 0.66956 0.16823 0 10.1025 0 0 0 0 0 0 0 0 0 0 O60563 CCNT1_HUMAN Cyclin-T1 (CycT1) (Cyclin-T) CCNT1 Homo sapiens (Human) "cell division [GO:0051301]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]" cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691] 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976] LEPTQGHR;NNNKRWYFTR;WSNWEIPVSTDGK 3 4.3 0.92616 -0.45322 0 0 0 0 0 0 0 0 0 0 0 10.3948 O60565 GREM1_HUMAN "Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)" GREM1 CKTSF1B1 DAND2 DRM PIG2 Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; collagen fibril organization [GO:0030199]; determination of dorsal identity [GO:0048263]; embryonic limb morphogenesis [GO:0030326]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone mineralization [GO:0030502]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of bone remodeling [GO:0046851]; negative regulation of bone trabecula formation [GO:1900155]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast proliferation [GO:0090291]; negative regulation of SMAD protein signal transduction [GO:0060392]; positive regulation of angiogenesis [GO:0045766]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of receptor internalization [GO:0002092]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; sequestering of BMP from receptor via BMP binding [GO:0038098]; signal transduction [GO:0007165]; ureteric bud formation [GO:0060676] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] BMP binding [GO:0036122]; cytokine activity [GO:0005125]; morphogen activity [GO:0016015]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 2 binding [GO:0043184] YLKRDWCK 1 4.3 0.95556 -0.9338 0 0 0 8.5868 0 0 0 0 0 0 0 0 O60566 BUB1B_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) BUB1B BUBR1 MAD3L SSK1 Homo sapiens (Human) "apoptotic process [GO:0006915]; cell division [GO:0051301]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]" anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AVEALQGENFRK;VLAQRRPLAVLK 2 2.6 0.91029 -0.28434 9.13901 0 0 0 0 0 0 0 0 5.27917 0 0 O60568 PLOD3_HUMAN "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]" PLOD3 Homo sapiens (Human) basement membrane assembly [GO:0070831]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; hydroxylysine biosynthetic process [GO:0046947]; in utero embryonic development [GO:0001701]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; vasodilation [GO:0042311] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094] DVFSGSDTDPDMAFCK;LLFSAESFCWPEWGLAEQYPEVGTGK;LSLNLDHK;LSLNLDHKSRIFQNLNGALDEVVLK;TVGGGQKVR 5 10.3 0.97618 -2.2521 0 0 0 0 0 11.0088 0 0 0 11.6631 9.4348 0 O60575 ISK4_HUMAN Serine protease inhibitor Kazal-type 4 (Peptide PEC-60 homolog) SPINK4 Homo sapiens (Human) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] QDIQIMK 1 8.1 0.91636 -0.35087 0 0 0 0 0 0 0 0 0 0 10.9146 0 O60583 CCNT2_HUMAN Cyclin-T2 (CycT2) CCNT2 Homo sapiens (Human) "cell division [GO:0051301]; early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of muscle cell differentiation [GO:0051147]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]" cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription coactivator binding [GO:0001223] EKSGSLKLR;EQLENTPSR;IRNWRANQAAR;VEEQARK;WSNWEIPVSTDGK 5 6.7 0.97542 -4.2245 9.47667 12.4516 0 0 0 0 0 0 8.74578 0 9.95262 0 O60602 TLR5_HUMAN Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor signaling pathway [GO:0002224] plasma membrane [GO:0005886] interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] VAYIDLQK;VLNLAYNKINK 2 2.2 0.94224 -0.61563 0 0 0 0 0 0 0 11.7986 0 9.59044 0 0 O60603 TLR2_HUMAN Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282) TLR2 TIL4 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; cellular response to type II interferon [GO:0071346]; central nervous system myelin formation [GO:0032289]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; learning [GO:0007612]; leukotriene metabolic process [GO:0006691]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phagocytosis [GO:0050765]; negative regulation of synapse assembly [GO:0051964]; nitric oxide metabolic process [GO:0046209]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] cell body [GO:0044297]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule membrane [GO:0030667]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] "amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; Toll-like receptor binding [GO:0035325]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]" TLGETSLFSHLTK 1 1.7 0.74611 0.086113 0 0 9.05298 0 0 0 0 0 0 0 0 0 O60609 GFRA3_HUMAN GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3) GFRA3 UNQ339/PRO538/PRO3664 Homo sapiens (Human) glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; peripheral nervous system development [GO:0007422]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] axon guidance receptor activity [GO:0008046]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] LNMLKPDSDLCLK;NSSLIGCMCHR 2 6 0.87987 -0.14583 0 0 0 10.6432 0 0 0 0 0 0 0 0 O60609 GFRA3_HUMAN GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3) GFRA3 UNQ339/PRO538/PRO3664 Homo sapiens (Human) glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; peripheral nervous system development [GO:0007422]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] axon guidance receptor activity [GO:0008046]; glial cell-derived neurotrophic factor receptor activity [GO:0016167]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] NSSLIGCMCHR;SLDSDLCLK 2 5.4 0.9353 -0.51728 0 3.63308 0 0 0 0 0 0 9.3347 0 0 0 O60610 DIAP1_HUMAN Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) DIAPH1 DIAP1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to histamine [GO:0071420]; cytoskeleton organization [GO:0007010]; protein localization to microtubule [GO:0035372]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule-based process [GO:0032886]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667] actin binding [GO:0003779]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] AEMDEVER;ESSKSAMMYIQELRSGLR;HELQVEMKKMESDFEQK;LEKQQKR;MEMDDFNEVFQILLNTVK;QMPEPEQLK 6 6.1 0.97409 -3.7916 11.2324 6.50917 0 0 0 9.46367 0 0 0 0 11.701 0 O60613 SEP15_HUMAN Selenoprotein F (15 kDa selenoprotein) SELENOF SEP15 Homo sapiens (Human) 'de novo' post-translational protein folding [GO:0051084]; sperm DNA condensation [GO:0035092] endoplasmic reticulum lumen [GO:0005788] oxidoreductase activity [GO:0016491]; selenium binding [GO:0008430]; thioredoxin peroxidase activity [GO:0008379] GSDPVLK 1 4.2 0.55164 0.18326 0 0 0 0 0 0 0 0 0 0 10.1608 0 O60637 TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8) TSPAN3 TM4SF8 Homo sapiens (Human) extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] AIDYVQR 1 2.8 0.90919 -0.30917 0 0 0 0 0 0 0 0 9.58449 0 0 0 O60645 EXOC3_HUMAN Exocyst complex component 3 (Exocyst complex component Sec6) EXOC3 SEC6 SEC6L1 Homo sapiens (Human) exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; presynaptic membrane [GO:0042734]; secretory granule membrane [GO:0030667] cadherin binding [GO:0045296]; SNARE binding [GO:0000149] ESDKMWLVR;IKKPYKK;MFTILERTVTTR 3 3.8 0.9743 -3.6492 0 8.28082 0 0 9.48494 0 0 0 0 4.65008 0 0 O60658 PDE8A_HUMAN "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)" PDE8A Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]" EDNQCNGFCRACEK 1 1.7 0.83253 -0.028618 0 11.4551 0 0 0 0 0 0 0 0 0 0 O60662 KLH41_HUMAN Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) KLHL41 KBTBD10 KRP1 Homo sapiens (Human) myofibril assembly [GO:0030239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; pseudopodium assembly [GO:0031269]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; skeletal muscle cell differentiation [GO:0035914]; striated muscle contraction [GO:0006941] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; M band [GO:0031430]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; sarcoplasmic reticulum membrane [GO:0033017] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DDIIKSNPDLQKK;EEAVFEAVMKWVRTDK;IYVVAGK 3 5.9 0.98051 -1.6418 0 6.4454 0 0 0 0 0 0 0 0 0 0 O60663 LMX1B_HUMAN LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B) LMX1B Homo sapiens (Human) dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GQGSQSKGSGDDGKDPR;VVQVWFQNQRAKMK 2 7.7 0.85632 -0.080848 0 0 0 0 0 0 0 0 10.9566 0 0 0 O60664 PLIN3_HUMAN Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) PLIN3 M6PRBP1 TIP47 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; positive regulation of sequestering of triglyceride [GO:0010890]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; transport vesicle [GO:0030133] cadherin binding [GO:0045296] DTVATQLSEAVDATR;IATSLDGFDVASVQQQR;LGSLSER;SVVTGGVQSVMGSR;VSGAQEMVSSAK 5 15 0.2513 0.27657 10.1936 0 10.3426 0 0 0 0 0 0 8.14629 8.54485 0 O60667 FCMR_HUMAN Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso) FCMR FAIM3 TOSO Homo sapiens (Human) cellular defense response [GO:0006968]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; immunoglobulin transcytosis in epithelial cells [GO:0002414]; negative regulation of apoptotic process [GO:0043066]; regulation of B cell receptor signaling pathway [GO:0050855]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] high-affinity IgM receptor activity [GO:0002172]; IgM binding [GO:0001791]; polymeric immunoglobulin binding [GO:0001790] EGQGFHILIPTILGLFLLALLGLVVK;SQNNIYSACPR 2 9.5 0.91635 -0.43316 0 0 0 0 0 0 0 4.27001 0 0 0 0 O60669 MOT2_HUMAN Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Homo sapiens (Human) lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate secondary active transmembrane transporter activity [GO:0005477]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293] ERKEENAR;VNKYLDFSLFK 2 4 0.90804 -0.27706 0 11.401 0 0 0 0 0 9.08781 0 0 0 0 O60673 REV3L_HUMAN DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) REV3L POLZ REV3 Homo sapiens (Human) DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; error-prone translesion synthesis [GO:0042276] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" DSPFIHMHR;GTISQYFTTLHCPVCDDLTQHGICSKCR;LQPGNKPSRLK;VPDDKIENR;VSLVSGMPFYGYHEKERHFMK 5 2.5 0.97488 -3.2619 12.1862 12.6607 4.71957 13.19 0 0 0 0 0 8.33561 0 4.83825 O60674 JAK2_HUMAN Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) JAK2 Homo sapiens (Human) actin filament polymerization [GO:0030041]; activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to virus [GO:0098586]; collagen-activated signaling pathway [GO:0038065]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; extrinsic apoptotic signaling pathway [GO:0097191]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mammary gland epithelium development [GO:0061180]; mesoderm development [GO:0007498]; microglial cell activation [GO:0001774]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron apoptotic process [GO:0043524]; nuclear receptor-mediated mineralocorticoid signaling pathway [GO:0031959]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [GO:1902728]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; response to amine [GO:0014075]; response to antibiotic [GO:0046677]; response to hydroperoxide [GO:0033194]; response to interleukin-12 [GO:0070671]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; symbiont-induced defense-related programmed cell death [GO:0034050]; thrombopoietin-mediated signaling pathway [GO:0038163]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; euchromatin [GO:0000791]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] acetylcholine receptor binding [GO:0033130]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; interleukin-12 receptor binding [GO:0005143]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; peptide hormone receptor binding [GO:0051428]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; type 1 angiotensin receptor binding [GO:0031702] IWYPPNHVFHIDESTR;VDQIRDNMAG 2 2.3 0.93685 -0.5646 0 0 0 0 1.97574 0 10.4075 0 0 0 0 0 O60676 CST8_HUMAN Cystatin-8 (Cystatin-related epididymal spermatogenic protein) CST8 CRES Homo sapiens (Human) cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity [GO:0004869] WLSLILLTIPLALVARK 1 12 0.64153 0.17263 0 0 0 6.82043 7.17632 0 0 0 5.50255 0 0 0 O60678 ANM3_HUMAN Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) PRMT3 HRMT1L3 Homo sapiens (Human) chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022] HGLEFYGYIKLINFIR;HMEARALSAEAALARAR;QTVFLLEKPFSVKAGEALK;TLISEPCGIK 4 11.7 0.95573 -0.98519 0 0 0 6.11226 0 7.85462 3.55385 6.32611 10.3718 0 7.45812 0 O60683 PEX10_HUMAN Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69) PEX10 RNF69 Homo sapiens (Human) "cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]" peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AVFVLRQGLACLQR 1 4.3 0.9222 -0.44289 0 8.53924 0 0 0 0 0 0 0 0 0 0 O60684 IMA7_HUMAN Importin subunit alpha-7 (Karyopherin subunit alpha-6) KPNA6 IPOA7 Homo sapiens (Human) entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; maternal process involved in female pregnancy [GO:0060135]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079] cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] EPSPPIDEVINTPR;VASPALR 2 3.9 0.86741 -0.091691 0 0 0 0 0 0 8.76769 8.89467 0 10.7838 0 0 O60687 SRPX2_HUMAN Sushi repeat-containing protein SRPX2 (Sushi-repeat protein upregulated in leukemia) SRPX2 SRPUL Homo sapiens (Human) angiogenesis [GO:0001525]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; vocalization behavior [GO:0071625] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synaptic membrane [GO:0097060] hepatocyte growth factor binding [GO:0036458]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] CDYSCSSGYHLEGDR 1 3.2 0.66017 0.16903 0 0 0 4.86528 0 0 0 0 0 0 0 0 O60701 UGDH_HUMAN UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) UGDH Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; neuron development [GO:0048666]; protein hexamerization [GO:0034214]; UDP-glucuronate biosynthetic process [GO:0006065] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] IIDSLFNTVTDKK;ILTTNTWSSELSK;IPYAPSGEIPK;KIAILGFAFK;VLIGGDETPEGQR;VTVVDVNESR;YIEACARR;YWQQVIDMNDYQRRR 8 18.6 0 1.7932 12.1258 11.0331 0 9.5889 10.1445 0 9.95178 10.2271 0 10.8823 11.3438 11.3367 O60706 ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) ABCC9 SUR2 Homo sapiens (Human) action potential [GO:0001508]; ATP metabolic process [GO:0046034]; cardiac conduction [GO:0061337]; cardiac muscle cell contraction [GO:0086003]; cellular respiration [GO:0045333]; cellular response to ATP [GO:0071318]; cellular response to calcium ion [GO:0071277]; cellular response to chemical stress [GO:0062197]; cellular response to potassium ion [GO:0035865]; cellular response to xenobiotic stimulus [GO:0071466]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; fatty acid oxidation [GO:0019395]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; MAPK cascade [GO:0000165]; mitochondrion organization [GO:0007005]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; oxygen metabolic process [GO:0072592]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to ATP [GO:0033198]; response to estrogen [GO:0043627]; response to hydrogen peroxide [GO:0042542]; response to hydrogen sulfide [GO:1904880]; response to hypoxia [GO:0001666]; response to peptide [GO:1901652]; skeletal muscle tissue development [GO:0007519]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311] inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcolemma [GO:0042383]; sarcomere [GO:0030017] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activator activity [GO:0099104]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325] EAKAQMEDEDEEEEEEEDEDDNMSTVMR;LYAWEHIFCK;VADHPNR;VHTILTADLVIVMKR 4 3.9 0.97529 -1.4544 0 0 4.78738 0 0 0 0 8.79795 0 0 0 0 O60716 CTND1_HUMAN Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) CTNND1 KIAA0384 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of protein localization to cell-cell junction [GO:0150107]; protein stabilization [GO:0050821]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt signaling pathway [GO:0016055] "adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; presynaptic active zone cytoplasmic component [GO:0098831]; Schaffer collateral - CA1 synapse [GO:0098685]; zonula adherens [GO:0005915]" beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; protein sequestering activity [GO:0140311]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102] DEWFSRGK;IYISLLKESK;LDAVKSNAAAYLQHLCYR;LVENCVCLLR;NLAVDAR 5 5.5 0.97319 -2.5651 11.7004 0 0 0 0 9.39923 0 0 0 8.86456 0 0 O60721 NCKX1_HUMAN Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1) SLC24A1 KIAA0702 NCKX1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; response to light intensity [GO:0009642]; sodium ion transmembrane transport [GO:0035725]; visual perception [GO:0007601] cell surface [GO:0009986]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; outer membrane [GO:0019867]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]" DSDITATYKILETNSLKR;MIPTTTK;MIPTTTKNNYSPTAAGTERR;TLTYYTSTSSR;YTPSPRGR 5 5.2 0.97435 -3.6303 0 10.6356 10.1951 0 0 0 0 0 7.45812 0 9.77975 9.90076 O60729 CC14B_HUMAN Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) CDC14B Homo sapiens (Human) cilium assembly [GO:0060271]; DNA repair [GO:0006281]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cytokinesis [GO:0032467]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein dephosphorylation [GO:0006470]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" ILIFGETSYIPFR;SLSISRTK 2 4.2 0.97161 -1.3549 0 0 0 0 0 0 12.2166 0 0 0 0 0 O60729 CC14B_HUMAN Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) CDC14B Homo sapiens (Human) cilium assembly [GO:0060271]; DNA repair [GO:0006281]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cytokinesis [GO:0032467]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein dephosphorylation [GO:0006470]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" ILIFGETSYIPFR;LLIWLGIHKD 2 4.9 0.92953 -0.48596 0 0 0 0 0 0 0 0 0 0 0 9.78485 O60732 MAGC1_HUMAN Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) MAGEC1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] LLILILSIIFIK 1 1.1 0.80582 0.0082938 0 0 0 0 0 0 0 0 0 0 0 4.55133 O60733 PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) PLA2G6 PLPLA9 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; chemotaxis [GO:0006935]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; platelet activating factor metabolic process [GO:0046469]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cytosol [GO:0005829]; extracellular space [GO:0005615]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; calmodulin binding [GO:0005516]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophospholipase activity [GO:0004622]; phospholipase A2 activity [GO:0004623]; serine hydrolase activity [GO:0017171] GLIIIQLLIAIEK;QPAELHLFR 2 2.7 0.88148 -0.15137 0 0 0 8.74712 0 0 0 0 0 0 9.53572 0 O60741 HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) HCN1 BCNG1 Homo sapiens (Human) "apical protein localization [GO:0045176]; cellular response to cAMP [GO:0071320]; cellular response to interferon-beta [GO:0035458]; general adaptation syndrome, behavioral process [GO:0051867]; maternal behavior [GO:0042711]; negative regulation of action potential [GO:0045759]; neuronal action potential [GO:0019228]; positive regulation of membrane hyperpolarization [GO:1902632]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to L-glutamate [GO:1902065]; retinal cone cell development [GO:0046549]; sodium ion transmembrane transport [GO:0035725]" apical dendrite [GO:0097440]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787] "cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential [GO:0140232]; intracellularly cAMP-activated cation channel activity [GO:0005222]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium channel activity [GO:0005267]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]" FTKILSLLRLLR;ILSLLRLLRLSR;LGTPPGGGGAGAK;QKIHDYYEHRYQGK 4 4.7 0.97829 -1.9829 0 0 0 0 0 0 0 11.0374 0 0 0 0 O60749 SNX2_HUMAN Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) SNX2 TRG9 Homo sapiens (Human) "early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; retrograde transport, endosome to Golgi [GO:0042147]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]" cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459] SIVGMTK;SIVGMTKVKVGK;VGKEDSSSTEFVEKR 3 4.6 0.88608 -0.19564 0 10.4551 0 0 9.0814 0 0 9.80266 8.66249 0 2.91565 0 O60759 CYTIP_HUMAN Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) CYTIP PSCDBP Homo sapiens (Human) regulation of cell adhesion [GO:0030155] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleoplasm [GO:0005654] FIPGLHRAVEEEESR;SSGNLLTIETLNGTMILKR 2 9.5 0.97227 -1.3627 0 0 0 0 8.53181 11.0647 0 0 0 0 0 0 O60763 USO1_HUMAN General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) USO1 VDP Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; regulation of cellular response to insulin stimulus [GO:1900076]; secretory granule localization [GO:0032252]; small GTPase-mediated signal transduction [GO:0007264]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133] cadherin binding [GO:0045296]; RNA binding [GO:0003723] LELEITDSKK;NMIREQDLQLEELRQQVSTLK 2 3.2 0.94479 -0.64974 4.03466 0 0 0 0 0 0 0 0 0 0 0 O60765 Z354A_HUMAN Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF) ZNF354A EZNF HKL1 TCF17 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LEKPYIYEGRLEKK;NLVSLGLPFTKPK;NTELSQNFSPKSVLIR 3 7.1 0.97599 -2.2559 0 0 10.8029 0 0 0 0 0 0 0 0 11.6913 O60774 FMO6_HUMAN Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Dimethylaniline oxidase 6) (Flavin-containing monooxygenase 6) (FMO 6) FMO6P FMO6 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" FSDHTEEGR;LQEYIKTYAQK;NAILTQWNR 3 5.4 0.96431 -1.1759 0 0 0 0 0 0 0 10.2121 0 0 0 0 O60784 TOM1_HUMAN Target of Myb1 membrane trafficking protein (Target of Myb protein 1) TOM1 Homo sapiens (Human) autophagosome-lysosome fusion [GO:0061909]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; positive regulation of autophagosome maturation [GO:1901098]; protein transport [GO:0015031]; regulation of endosome organization [GO:1904978]; signal transduction [GO:0007165]; substrate localization to autophagosome [GO:0061753] azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; myosin VI binding [GO:0070853]; phosphatidylinositol-5-phosphate binding [GO:0010314]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130] GVTSEGKFDK;LPNLSSPSAEGPPGPPSGPAPR;LRSELEMVSGNVR 3 9.8 0.97584 -2.3005 12.6289 9.29932 0 0 0 6.86431 0 0 0 0 0 0 O60809 PRA10_HUMAN PRAME family member 10 PRAMEF10 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LQVLDLRDVDENFWTIWSGAR;TLVLKDCR 2 6.1 0.93539 -0.52116 0 9.53251 0 0 9.49524 0 0 0 0 0 0 0 O60810 PRAM4_HUMAN PRAME family member 4 PRAMEF4 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ILFCTDYCPDCGNRSFYDLEADQYCC;LPLRPLIK;RLPLRPLIK;SFYDLEADQYCC;TLDEYLTCLLLWVKQR;WVLPILTQFTPYLGHMRNLQK 6 15.1 0.84278 -0.043106 0 0 2.47257 0 0 0 5.32048 0 0 0 0 0 O60811 PRAM2_HUMAN PRAME family member 2 PRAMEF2 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AELMCTLREFRQPK;YLFQWVYQRR 2 5.1 0.86453 -0.087652 0 0 0 0 0 0 0 0 0 0 0 6.90869 O60812 HNRC1_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) HNRNPCL1 HNRPCL1 Homo sapiens (Human) nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; RNA binding [GO:0003723] AAVAGEDGR;ASNVTNK;IAGCSVHK;LSGNTSRRGK;QKVDSLLENLEK;SDVEAIFSK;VDSLLENLEK;VFIGNLNTLVVK;YGKIAGCSVHKGFAFVQYDK 9 27 0.87624 -0.12362 0 0 9.83972 0 9.13168 0 0 0 9.90239 0 0 10.4509 O60825 F262_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB2 Homo sapiens (Human) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; positive regulation of insulin secretion [GO:0032024]; response to glucose [GO:0009749]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; protein kinase binding [GO:0019901]" CLLAYFLDK;IVYYLMNIHVQPR;TPNLRMSEKK 3 6.3 0.67426 0.16661 0 0 0 0 0 0 0 0 0 10.8766 0 0 O60826 CCD22_HUMAN Coiled-coil domain-containing protein 22 CCDC22 CXorf37 JM1 Homo sapiens (Human) cytoplasmic sequestering of NF-kappaB [GO:0007253]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; intracellular copper ion homeostasis [GO:0006878]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein transport [GO:0015031] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654] cullin family protein binding [GO:0097602] AIGSQIR;VIHLAGQWEK 2 2.7 0.93194 -0.49281 0 0 0 0 0 0 0 0 0 0 0 11.1351 O60828 PQBP1_HUMAN Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) PQBP1 NPW38 JM26 Homo sapiens (Human) "activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; ribonucleoprotein complex binding [GO:0043021]; transcription coactivator activity [GO:0003713] SSNADLCPQMLKK;TGAMTSR 2 21.1 0.94782 -0.66344 10.5232 0 0 0 0 0 0 0 0 8.87949 8.79315 0 O60829 PAGE4_HUMAN P antigen family member 4 (PAGE-4) (G antigen family C member 1) (PAGE-1) PAGE4 GAGEC1 JM27 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; regulation of stress-activated MAPK cascade [GO:0032872]; response to starvation [GO:0042594] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; transcription coactivator activity [GO:0003713] EAGDGQP;VEGDCQEMDLEKTR 2 20.6 0.91131 -0.28615 0 0 0 0 10.1957 0 0 0 0 0 0 0 O60830 TI17B_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-B TIMM17B TIM17B JM3 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] protein transmembrane transporter activity [GO:0008320] NAPPFLEDPSQLPPKDGTPAPGYPSYQQYH 1 17.4 0.84192 -0.045328 0 5.61132 0 0 0 0 0 0 0 0 0 0 O60832 DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) DKC1 NOLA4 Homo sapiens (Human) box H/ACA sno(s)RNA 3'-end processing [GO:0000495]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to Cajal body [GO:1904867]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snRNA pseudouridine synthesis [GO:0031120]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004] box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034] ALETLTGALFQRPPLIAAVKR;EVELVSE;VTGCLIVCIERATRLVK 3 8.8 0.92427 -0.45054 0 0 0 0 11.8145 0 9.84939 0 0 0 0 0 O60840 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4) CACNA1F CACNAF1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; visual perception [GO:0007601] membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor outer segment [GO:0001750]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AFRVLRPLRLVSGVPSLHIVLNSIMK;ILRVLRVLRPLR;NQHSKHKTVAVASAQR;VLRVLRPLRAINR;VTRHWASLSNLVASLLNSMK 5 3.9 0.91569 -0.34532 0 13.0981 0 0 0 0 0 0 0 0 8.89597 0 O60841 IF2P_HUMAN Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; synapse [GO:0045202] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] DQSKQKESQR;EELETGKK;EMSSDSEYDSDDDR;RLAHCEELRAQVMEVK;SKKTAKPK;TAKPKVEMYSGSDDDDDFNKLPK;VEMYSGSDDDDDFNK;WDGSEEDEDNSK 8 7 0.97834 -1.9782 4.02015 4.09229 4.80488 0 9.19476 4.48967 10.5444 4.72841 0 0 4.09795 7.43045 O60858 TRI13_HUMAN E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13) TRIM13 LEU5 RFP2 RNF77 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; perinuclear endoplasmic reticulum [GO:0097038] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase activity [GO:0061659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GDALSRLDTLETSKR;VIKETPLPPSNLPASPLMK 2 8.4 0.91685 -0.36303 0 11.3795 0 0 0 0 0 0 0 0 0 4.98914 O60861 GAS7_HUMAN Growth arrest-specific protein 7 (GAS-7) GAS7 KIAA0394 Homo sapiens (Human) actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812] actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] ALTERQR;CRTLYPFSGER;ENFKKDMK 3 5.5 0.97248 -2.7552 0 0 0 0 0 0 7.40096 0 0 0 0 0 O60861 GAS7_HUMAN Growth arrest-specific protein 7 (GAS-7) GAS7 KIAA0394 Homo sapiens (Human) actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812] actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] ALTERQR;ENFKKDMK;SNMENSFDDVSCLSPQNLGSSSPSK 3 11.9 0.71288 0.15167 0 0 0 0 0 0 7.1416 0 0 0 0 0 O60869 EDF1_HUMAN Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) EDF1 Homo sapiens (Human) endothelial cell differentiation [GO:0045446]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid metabolic process [GO:0019216] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713] AESDWDTVTVLR;AIPNNQVLGK 2 14.9 0.0045767 1.2458 0 0 10.4383 0 0 0 0 0 0 10.327 10.4186 0 O60870 KIN17_HUMAN "DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)" KIN BTCD KIN17 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mRNA processing [GO:0006397] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] EVIDKYTAVVKMIDSGDK;GWYIQYIDRDPETIRR;KAIVKEVIDK;KLGEKYHK;LRWYCQMCQK 5 14.5 0.97295 -2.9527 3.96818 0 12.9844 13.4057 0 0 0 0 8.78146 8.6762 0 0 O60879 DIAP2_HUMAN Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) DIAPH2 DIA Homo sapiens (Human) actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]; oogenesis [GO:0048477] actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730] actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] IEPTELSENCFWLRVKEDK;INFLCKIRDTK;KNQYKLIQCLK;LIQCLKAFMNNK;MYKPEVSMK;TAREQYEK 6 5.8 0.97566 -4.3616 0 9.39909 10.9766 0 0 0 0 0 9.49259 10.3291 0 0 O60880 SH21A_HUMAN SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP) SH2D1A DSHP SAP Homo sapiens (Human) adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; humoral immune response [GO:0006959]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776] cytoplasm [GO:0005737]; cytosol [GO:0005829] protein-macromolecule adaptor activity [GO:0030674] QKQVLGVLSISEARSR 1 21.1 0.43923 0.1946 0 0 0 0 0 0 0 8.38111 0 0 0 0 O60882 MMP20_HUMAN Matrix metalloproteinase-20 (MMP-20) (EC 3.4.24.-) (Enamel metalloproteinase) (Enamelysin) MMP20 Homo sapiens (Human) amelogenesis [GO:0097186]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of enamel mineralization [GO:0070173] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] TIYDFGFPR 1 1.9 0.90969 -0.31627 0 0 0 0 0 0 0 0 0 9.20026 0 0 O60884 DNJA2_HUMAN DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) DNAJA2 CPR3 HIRIP4 Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] GSGGGQR;RGEDMMHPLK;VIEPGCVR;VSLEDLYNGK 4 8.5 0.93222 -0.49345 0 0 0 0 0 7.7937 0 0 11.6014 0 8.86415 0 O60885 BRD4_HUMAN Bromodomain-containing protein 4 (Protein HUNK1) BRD4 HUNK1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; P-TEFb complex binding [GO:0106140]; p53 binding [GO:0002039]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LAELQEQLK;TLWKHQFAWPFQQPVDAVK;VVAPPSSSDSSSDSSSDSDSSTDDSEEER 3 4.2 0.9093 -0.29676 0 0 0 5.62439 5.28777 4.46473 0 9.59354 0 0 5.43196 0 O60888 CUTA_HUMAN Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) CUTA ACHAP C6orf82 Homo sapiens (Human) protein localization [GO:0008104]; response to metal ion [GO:0010038] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739] copper ion binding [GO:0005507]; enzyme binding [GO:0019899] PALLPVASRLLLLPR;TQSSLVPALTDFVR 2 18.6 0.35099 0.23476 0 0 0 4.8479 0 0 0 0 10.7723 0 4.07519 0 O60890 OPHN1_HUMAN Oligophrenin-1 OPHN1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cerebellar granule cell differentiation [GO:0021707]; cerebral cortex neuron differentiation [GO:0021895]; establishment of epithelial cell apical/basal polarity [GO:0045198]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of proteasomal protein catabolic process [GO:1901799]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synaptic vesicle endocytosis [GO:0048488]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; terminal bouton [GO:0043195] actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; ionotropic glutamate receptor binding [GO:0035255]; phospholipid binding [GO:0005543] DVIKDGNALISAMR;ELVSAAKSDNLDYR;TITSSLKFYLRNLSEPVMTYR 3 6.1 0.88232 -0.16738 11.5265 0 0 0 0 0 0 0 0 0 9.09342 0 O60906 NSMA_HUMAN Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1) SMPD2 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; sphingolipid catabolic process [GO:0030149]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684] caveola [GO:0005901]; cell periphery [GO:0071944]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767] IDYVLYKAVSGFYISCK 1 4 0.91782 -0.43503 0 0 0 0 0 0 0 0 0 0 0 10.569 O60907 TBL1X_HUMAN "F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)" TBL1X TBL1 Homo sapiens (Human) fat cell differentiation [GO:0045444]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to steroid hormone [GO:0048545]; sensory perception of sound [GO:0007605] histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] GDKVGASASDGSVCVLDLRK;GPIFALK 2 4.7 0.74001 0.10561 0 0 0 0 0 0 0 0 9.20928 0 0 10.5178 O60909 B4GT2_HUMAN "Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)" B4GALT2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cerebellar Purkinje cell layer development [GO:0021680]; glycosylation [GO:0070085]; locomotory behavior [GO:0007626]; memory [GO:0007613]; protein glycosylation [GO:0006486]; visual learning [GO:0008542] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; lactose synthase activity [GO:0004461]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]" LLIEFTSPMPLER 1 3.5 0.87409 -0.10523 0 0 0 0 0 0 0 0 12.5726 0 0 0 O60921 HUS1_HUMAN Checkpoint protein HUS1 (hHUS1) HUS1 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; response to UV [GO:0009411]; telomere maintenance [GO:0000723] checkpoint clamp complex [GO:0030896]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] ISNMIAK;IVTHDIPIKVIPRK;NVEHMAEVHIDIRK 3 12.5 0.92971 -0.4684 0 12.5514 2.33902 0 3.94298 0 0 0 0 12.4366 0 0 O60927 PP1RB_HUMAN E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) PPP1R11 HCGV TCTE5 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634] phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630] CCCIYEKPR;SLTIKLR 2 12.7 0.98059 -1.6607 0 10.7909 11.0322 0 9.82677 6.1328 6.13902 0 0 0 0 0 O60930 RNH1_HUMAN Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II) RNASEH1 RNH1 Homo sapiens (Human) "DNA replication, removal of RNA primer [GO:0043137]; RNA catabolic process [GO:0006401]" mitochondrion [GO:0005739] magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; RNA-DNA hybrid ribonuclease activity [GO:0004523] GFGMFYAVRR;KNGWKTSAGK 2 7 0.98117 -1.756 0 0 0 0 0 0 0 0 11.9685 9.63914 0 0 O60931 CTNS_HUMAN Cystinosin CTNS Homo sapiens (Human) adult walking behavior [GO:0007628]; amino acid metabolic process [GO:0006520]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; brush border assembly [GO:1904970]; cognition [GO:0050890]; glutathione metabolic process [GO:0006749]; grooming behavior [GO:0007625]; L-cystine transport [GO:0015811]; lens development in camera-type eye [GO:0002088]; long-term memory [GO:0007616]; melanin biosynthetic process [GO:0042438]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; proximal tubule morphogenesis [GO:0072158]; regulation of melanin biosynthetic process [GO:0048021]; regulation of TORC1 signaling [GO:1903432]; renal albumin absorption [GO:0097018]; renal D-glucose absorption [GO:0035623]; renal phosphate ion absorption [GO:0097291]; renal water absorption [GO:0070295]; thyroid gland development [GO:0030878]; transmembrane transport [GO:0055085]; visual learning [GO:0008542] extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886] L-cystine transmembrane transporter activity [GO:0015184]; solute:proton symporter activity [GO:0015295] IRNWLTIFILFPLK 1 3.8 0.83296 -0.028384 0 6.94287 0 0 0 0 0 0 0 0 0 0 O60934 NBN_HUMAN Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) NBN NBS NBS1 P95 Homo sapiens (Human) "blastocyst growth [GO:0001832]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway [GO:0097193]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein K63-linked ubiquitination [GO:0070534]; protein localization to site of double-strand break [GO:1990166]; R-loop processing [GO:0062176]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated DNA replication initiation [GO:0030174]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomere maintenance via telomere trimming [GO:0090737]; telomeric 3' overhang formation [GO:0031860]" "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539] ISQENEIGKK;KLLLTEFRSLVIK;KNTELEEWLR;LQDDSEMLPK;QEEDVNVRKRPR 5 7.3 0.96464 -1.169 0 0 0 0 0 0 11.6147 0 9.06808 0 0 0 O60936 NOL3_HUMAN Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) NOL3 ARC NOP Homo sapiens (Human) blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; intrinsic apoptotic signaling pathway [GO:0097193]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein complex oligomerization [GO:0051259]; regulation of gene expression [GO:0010468]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to hypoxia [GO:0001666]; response to injury involved in regulation of muscle adaptation [GO:0014876]; response to ischemia [GO:0002931]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; sarcoplasmic reticulum [GO:0016529] calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] SQSQSWNPR 1 4.1 0.93583 -0.51917 0 0 0 0 0 0 0 0 0 9.4632 0 0 O60936 NOL3_HUMAN Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) NOL3 ARC NOP Homo sapiens (Human) blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; intrinsic apoptotic signaling pathway [GO:0097193]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein complex oligomerization [GO:0051259]; regulation of gene expression [GO:0010468]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to hypoxia [GO:0001666]; response to injury involved in regulation of muscle adaptation [GO:0014876]; response to ischemia [GO:0002931]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; sarcoplasmic reticulum [GO:0016529] calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] ATADAWGQK 1 3.3 0.90679 -0.30433 6.32894 0 7.95239 0 0 0 4.84258 5.67067 0 0 0 6.53528 O60938 KERA_HUMAN Keratocan (KTN) (Keratan sulfate proteoglycan keratocan) KERA SLRR2B Homo sapiens (Human) cornea development in camera-type eye [GO:0061303]; visual perception [GO:0007601] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] ISAHLQHLHLDHNK;ITNYGIEK;NLMQLNMAK;SLEQLQLARNKVSR 4 12.8 0.94424 -0.62671 8.32486 9.92499 4.69877 0 0 8.71346 10.9907 0 0 0 0 6.98687 O60941 DTNB_HUMAN Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) DTNB Homo sapiens (Human) neuron differentiation [GO:0030182]; synaptic signaling [GO:0099536] basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] zinc ion binding [GO:0008270] EILQEIQRLR;MIEESGNKR 2 3 0.97381 -1.4074 0 0 0 0 10.333 0 0 0 0 0 0 0 O60942 MCE1_HUMAN mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] RNGTT CAP1A Homo sapiens (Human) 7-methylguanosine mRNA capping [GO:0006370]; RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; inorganic triphosphate phosphatase activity [GO:0050355]; mRNA 5'-triphosphate monophosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; phosphoprotein phosphatase activity [GO:0004721]; polynucleotide 5'-phosphatase activity [GO:0004651]; RNA guanylyltransferase activity [GO:0008192] EVSHEMDGLIFQPTGK;IIECKFENNSWVFMR;LQCKGHGECPTTENTETFIRLCER;TGLIDKTQEPFSVR;VTKELKQYDNK 5 13.4 0.975 -2.363 13.5415 0 12.1578 0 8.79175 0 11.3295 4.97232 0 0 0 0 O75022 LIRB3_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a) LILRB3 ILT5 LIR3 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; immune response-regulating signaling pathway [GO:0002764]; negative regulation of osteoclast differentiation [GO:0045671] plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] VELDSQQSPHDEDPQAVTYAPVK 1 3.6 0.70089 0.16126 0 0 0 0 0 0 0 0 0 0 0 10.5718 O75027 ABCB7_HUMAN "Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)" ABCB7 ABC7 Homo sapiens (Human) intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]; transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] IIKAMLSYVWPKDRPDLR 1 2.4 0.96285 -1.0814 0 0 10.4255 0 0 0 0 0 0 0 0 0 O75031 HSF2B_HUMAN Heat shock factor 2-binding protein HSF2BP MEILB2 Homo sapiens (Human) double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DLERLTTEVMQIR 1 3.9 0.9225 -0.44275 0 0 0 0 0 0 0 0 11.515 0 0 0 O75037 KI21B_HUMAN Kinesin-like protein KIF21B KIF21B KIAA0449 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AEIARLQMELMEYKAGK;GLQVAQKEAQIRLLEGR;LIDELENSQRR;LLLDNFLK;LPHSGPP 5 3.7 0.975 -3.4502 11.7913 0 0 8.23903 0 0 0 0 0 10.3526 0 0 O75038 PLCH2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)" PLCH2 KIAA0450 PLCL4 Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] ENLAGAHMGR;NGRLVVGSFSRR;VKQALGLK;VSGPGVR;YLMAGISDEDSLAR 5 3.6 0.97851 -2.1195 0 0 0 10.8323 0 0 12.3092 0 12.2215 0 7.55513 11.6794 O75044 SRGP2_HUMAN SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A Homo sapiens (Human) actin filament severing [GO:0051014]; dendritic spine development [GO:0060996]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; filopodium assembly [GO:0046847]; inhibitory synapse assembly [GO:1904862]; lamellipodium assembly involved in ameboidal cell migration [GO:0003363]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron migration [GO:2001223]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] ALHIRKVLLVLPK;GLEHPLFPK;QAKYTENK;RRANQQETEQFYFTK;TLGESQRTDCSLARR;VLLVLPK 6 5.6 0.97927 -1.8851 0 0 11.5897 9.59653 0 3.41305 6.50125 0 8.74698 0 0 10.3822 O75051 PLXA2_HUMAN Plexin-A2 (Semaphorin receptor OCT) PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235 Homo sapiens (Human) centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154] ELEVQGNGQQHVEKALKLFAQLINNK;IEGDWKRLNTLMHYQVSDR;LQMQMDNLESR;TESVAEK;YSLSEDKLIRQQIEYK 5 4.2 0.97941 -2.0445 10.7105 0 0 9.57162 0 0 0 0 0 0 0 12.2894 O75052 CAPON_HUMAN Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) NOS1AP CAPON KIAA0464 Homo sapiens (Human) nitric oxide biosynthetic process [GO:0006809]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of potassium ion transmembrane transport [GO:1901381]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate by chemical signal [GO:0003062]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] anchoring junction [GO:0070161]; caveola [GO:0005901]; cytosol [GO:0005829]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018] nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase regulator activity [GO:0030235]; signaling adaptor activity [GO:0035591] DGASNIFR;DGASNIFRCNVFKSK;IFYVSHDSQDLK;YVGSLDVPRPNSR 4 7.9 0.97394 -1.4043 0 0 0 0 0 7.20006 0 11.0128 0 0 0 0 O75054 IGSF3_HUMAN Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3) IGSF3 EWI3 KIAA0466 Homo sapiens (Human) lacrimal gland development [GO:0032808] cell surface [GO:0009986]; membrane [GO:0016020] LSPVLYR;RPKNIPIIVLPLK 2 1.7 0.90929 -0.31282 0 0 0 11.3223 11.2268 0 12.3884 0 0 4.73086 0 8.90466 O75056 SDC3_HUMAN Syndecan-3 (SYND3) SDC3 KIAA0468 Homo sapiens (Human) cell migration [GO:0016477] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; microspike [GO:0044393]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] GLLLPPLLLLLLAGR 1 3.4 0.78138 0.021582 0 0 0 5.44135 0 0 0 0 0 0 0 0 O75061 AUXI_HUMAN Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) DNAJC6 KIAA0473 Homo sapiens (Human) clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular transport [GO:0046907]; regulation of clathrin coat assembly [GO:1905443]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle uncoating [GO:0016191] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density [GO:0014069]; vesicle [GO:0031982] "clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; heat shock protein binding [GO:0031072]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]" GASSPDMEPSYGGGLFDMVK;ILEWIEGKER;ILEWIEGKERNIR;SITVSPIPFFNKQR 4 5.1 0.64161 0.17351 0 0 0 0 0 10.3993 0 0 0 0 0 0 O75061 AUXI_HUMAN Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) DNAJC6 KIAA0473 Homo sapiens (Human) clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular transport [GO:0046907]; regulation of clathrin coat assembly [GO:1905443]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle uncoating [GO:0016191] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density [GO:0014069]; vesicle [GO:0031982] "clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; heat shock protein binding [GO:0031072]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]" ILEWIEGKER;ILEWIEGKERNIR;SITVSPIPFFNKQR;VNAGAAAR 4 3.6 0.97484 -3.7289 0 10.4583 0 0 0 0 0 9.44797 0 0 0 0 O75063 XYLK_HUMAN Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase) FAM20B KIAA0475 Homo sapiens (Human) proteoglycan biosynthetic process [GO:0030166] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" EDQRAFHR;QRVVLLAILLVIFIFTK 2 6.1 0.91667 -0.36237 0 3.72792 4.32005 5.99537 0 0 0 0 8.58237 0 0 0 O75064 DEN4B_HUMAN DENN domain-containing protein 4B DENND4B KIAA0476 Homo sapiens (Human) regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] DHVDIVAFDK;LSERQAR 2 1.1 0.98102 -1.7768 0 0 0 0 9.05704 0 0 0 0 10.6227 0 0 O75069 TMCC2_HUMAN Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) TMCC2 KIAA0481 hucep-11 Homo sapiens (Human) amyloid precursor protein metabolic process [GO:0042982] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] FGHGLKHLFHSR;IEQEARDDNVAEYLKLANNADK;MFGHGLKHLFHSR;VAYQSYER 4 6.8 0.97308 -2.8738 0 0 0 6.61133 0 10.6936 11.1544 0 11.3492 6.69349 0 0 O75071 EFC14_HUMAN EF-hand calcium-binding domain-containing protein 14 EFCAB14 KIAA0494 Homo sapiens (Human) calcium ion binding [GO:0005509] ELNALIGLAGDSR;TMESNQK 2 4 0.90939 -0.29569 0 0 7.16138 0 0 0 0 0 0 0 0 5.31448 O75072 FKTN_HUMAN Ribitol-5-phosphate transferase FKTN (EC 2.7.8.-) (Fukutin) (Fukuyama-type congenital muscular dystrophy protein) (Ribitol-5-phosphate transferase) FKTN FCMD Homo sapiens (Human) muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of JNK cascade [GO:0046329]; nervous system development [GO:0007399]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; regulation of protein glycosylation [GO:0060049] cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" NGAGLSK;VEDSLELSFQGKDDVK 2 5 0.92396 -0.44913 0 0 0 6.21525 0 0 0 0 0 10.0356 0 0 O75074 LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) LRP3 Homo sapiens (Human) negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898]; transport across blood-brain barrier [GO:0150104] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] LFHRPRAPR;LTVAYHAR;RCDGLQDCGDGSDEAGCPDLACGR 3 5.3 0.9812 -1.7891 0 0 0 0 0 7.4082 0 0 0 5.45503 0 9.30823 O75077 ADA23_HUMAN "Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)" ADAM23 MDC3 Homo sapiens (Human) cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; proteolysis [GO:0006508] extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] APSESAALDGHR;RAVNPSR 2 2.3 0.9517 -0.7015 0 0 0 0 7.02636 0 0 0 10.7759 0 0 0 O75078 ADA11_HUMAN "Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)" ADAM11 MDC Homo sapiens (Human) behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; establishment of protein localization [GO:0045184]; integrin-mediated signaling pathway [GO:0007229]; multicellular organismal response to stress [GO:0033555]; proteolysis [GO:0006508] axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] FCYEKLNVEGTER;YVELIVINDHQLFEQMR 2 3.9 0.96435 -1.2318 0 0 0 9.43388 0 0 11.7301 0 0 0 0 0 O75081 MTG16_HUMAN Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) CBFA2T3 MTG16 MTGR2 ZMYND4 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glycolytic process [GO:0045820]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of aerobic respiration [GO:1903715]; response to hypoxia [GO:0001666] Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AEEAVNEVK;LKRFLTTLQQFGSDISPEIGER 2 4.7 0.56184 0.18276 0 0 0 0 0 0 0 0 0 0 0 5.96917 O75083 WDR1_HUMAN WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) WDR1 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; apical junction assembly [GO:0043297]; cortical cytoskeleton organization [GO:0030865]; establishment of planar polarity of follicular epithelium [GO:0042247]; locomotion [GO:0040011]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; platelet formation [GO:0030220]; positive regulation of actin filament depolymerization [GO:0030836]; regulation of actin filament depolymerization [GO:0030834]; regulation of cell shape [GO:0008360]; regulation of oligodendrocyte differentiation [GO:0048713]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sarcomere organization [GO:0045214]; sensory perception of sound [GO:0007605] cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; podosome [GO:0002102] actin filament binding [GO:0051015] FSPDGNR;GNNFLYTNGK;IIGGDPK;NIDDHSRFVNCVR;VFASLPQVER 5 10.1 0.0048426 1.5743 0 0 12.3266 0 0 6.42512 11.8056 11.8908 12.285 6.21803 9.0465 7.63488 O75084 FZD7_HUMAN Frizzled-7 (Fz-7) (hFz7) (FzE3) FZD7 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; mesenchymal to epithelial transition [GO:0060231]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of ectodermal cell fate specification [GO:0042666]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphorylation [GO:0042327]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; stem cell population maintenance [GO:0019827]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] "frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]" ANGLMYFK;FYHRLSHSSK;TVAQGTK 3 4.4 0.9167 -0.42543 0 0 0 0 0 0 0 0 9.64703 0 8.49217 0 O75093 SLIT1_HUMAN Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal/ventral axon guidance [GO:0033563]; forebrain morphogenesis [GO:0048853]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; nuclear migration [GO:0007097]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord development [GO:0021510]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028] extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] CECMPGYAGDNCSENQDDCR;NLQLDKNQISCIEEGAFRALR;SLNSLVLYGNK 3 3.4 0.11852 0.36017 0 0 0 0 0 0 0 0 0 0 9.8471 0 O75094 SLIT3_HUMAN Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; atrioventricular valve morphogenesis [GO:0003181]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412] extracellular space [GO:0005615]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] DPCLGHRCHHGK;EYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGK;GFNVADVQKK;LDLSENQIQGIPR;LEQNSIK;LTRLDLSENQIQGIPR;NAERLDLDR 7 6 0.97437 -3.5148 0 0 0 0 0 0 0 0 0 0 10.2934 11.7274 O75095 MEGF6_HUMAN Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) extracellular region [GO:0005576] calcium ion binding [GO:0005509] LSADGCGCEDVDECASSR;TVYYMGYR;TVYYMGYRQVYTTEAR;YGPGCEQLCGCLNGGSCDAATGACR 4 3.8 0.68558 0.16318 0 9.5515 0 9.74876 0 0 10.8808 0 0 8.874 0 2.87425 O75095 MEGF6_HUMAN Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) extracellular region [GO:0005576] calcium ion binding [GO:0005509] CSCPPGAACHHVTGACRCPPGFTGSGCEQGCPPGR;LSADGCGCEDVDECASSR;YGPGCEQLCGCLNGGSCDAATGACR 3 6.3 0.91674 -0.42559 0 0 0 7.21189 0 0 0 0 0 0 0 0 O75096 LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) amyloid-beta clearance by cellular catabolic process [GO:0150094]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; enzyme-linked receptor protein signaling pathway [GO:0007167]; generation of neurons [GO:0048699]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; proximal/distal pattern formation [GO:0009954]; regulation of postsynapse assembly [GO:0150052]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; dendrite [GO:0030425]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; coreceptor activity [GO:0015026]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110] CDGDADCDDQSDER;CGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDK;CSDGSCIAEHWYCDGDTDCK;EFRCSDGSCIAEHWYCDGDTDCK;IEAIPKPAMYNQLCYK;KGYLFWTDWGHIAK 6 5.7 0.93701 -0.56522 0 8.74332 0 0 0 0 11.7271 0 8.06048 5.96405 3.93168 8.74356 O75106 AOC2_HUMAN Amine oxidase [copper-containing] 2 (EC 1.4.3.21) (Amine oxidase copper-containing 2) (Retina-specific copper amine oxidase) (RAO) (Semicarbazide-sensitive amine oxidase) (SSAO) AOC2 Homo sapiens (Human) amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; visual perception [GO:0007601]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] aliphatic amine oxidase activity [GO:0052595]; copper ion binding [GO:0005507]; electron transfer activity [GO:0009055]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038] GYRIQIHSPLGIHIPLESDMER 1 2.9 0.88336 -0.17387 0 0 0 0 0 0 0 0 8.99073 0 0 0 O75110 ATP9A_HUMAN Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A) ATP9A ATPIIA KIAA0611 Homo sapiens (Human) "endocytosis [GO:0006897]; negative regulation of exosomal secretion [GO:1903542]; neuron projection morphogenesis [GO:0048812]; phospholipid translocation [GO:0045332]; regulation of endocytic recycling [GO:2001135]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020] AGCCEWLRCCGGGEARPR;ELRSVMNTSNPR;IPGTVVR;IVYSWVIR;VPADMIFLR;VSVITLVSCLPLYVLK 6 6.7 0.97579 -2.3093 11.6048 5.81483 0 5.01163 9.79914 10.3917 3.77957 0 6.10293 0 0 0 O75112 LDB3_HUMAN LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) LDB3 KIAA0613 ZASP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; sarcomere organization [GO:0045214] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080] FNPSALK 1 1.1 0.92906 -0.48336 0 0 0 0 0 0 0 0 0 0 12.5247 0 O75113 N4BP1_HUMAN NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) N4BP1 KIAA0615 Homo sapiens (Human) cellular response to UV [GO:0034644]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of viral genome replication [GO:0045071]; regulation of innate immune response [GO:0045088] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; PML body [GO:0016605] mRNA binding [GO:0003729]; RNA nuclease activity [GO:0004540]; ubiquitin binding [GO:0043130] EFSAGTVYPETNK;LEEFLQKEVCLR;LGNRNITVFVPQWRTR;NITVFVPQWRTRR;TGGIIVTNDNFR 5 6 0.97988 -1.8396 0 8.37938 0 10.9616 0 0 0 0 0 0 4.68538 0 O75116 ROCK2_HUMAN "Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)" ROCK2 KIAA0619 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; endopeptidase activator activity [GO:0061133]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] ADHEADK;AQFEKQLLTER;ELEEEITLRK;KADHEADK;KADHEADKK;LFHVRPVTQTDVYRADAKEIPR;LKDEEISAAAIK;TESDTAARLRK 8 5.4 0.97553 -3.5791 0 0 8.58815 0 9.89168 0 0 10.2815 0 0 0 7.99061 O75122 CLAP2_HUMAN CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) CLASP2 KIAA0627 Homo sapiens (Human) "cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; presynaptic cytoskeleton organization [GO:0099187]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903]" axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802] actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782] SLQTYLKSSGSVASLPQSDR;TAKLYSV;VSAGSSK 3 7.9 0.71029 0.15766 0 0 0 0 0 5.53981 0 0 0 0 0 3.15381 O75122 CLAP2_HUMAN CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) CLASP2 KIAA0627 Homo sapiens (Human) "cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; presynaptic cytoskeleton organization [GO:0099187]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903]" axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802] actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782] ESSRDTSPVR;KDDGDSMCGGPGMSDPR;KEGLLGLQNLLKNQR;LDGTASEDGRVRAK;MGDAKDKVR;SLQTYLKSSGSVASLPQSDR;TLSRVELK;VSAGSSK 8 6.6 0.9758 -5.0961 11.0304 0 4.30816 0 0 0 0 11.7604 10.9367 7.76785 10.406 0 O75123 ZN623_HUMAN Zinc finger protein 623 ZNF623 KIAA0628 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFIQSSK;QVTVTHWK 2 2.8 0.91363 -0.39033 0 0 12.2283 0 0 0 0 0 0 0 0 0 O75127 PTCD1_HUMAN "Pentatricopeptide repeat-containing protein 1, mitochondrial" PTCD1 KIAA0632 Homo sapiens (Human) mitochondrial translation [GO:0032543]; tRNA 3'-end processing [GO:0042780] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; tRNA binding [GO:0000049] ALLPVLAKR;KLNYTYLISILK;NTYLEKIDGFRAYYK 3 5.1 0.89124 -0.21129 0 0 0 7.10643 0 0 0 10.0041 0 0 0 0 O75128 COBL_HUMAN Protein cordon-bleu COBL KIAA0633 Homo sapiens (Human) actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; collateral sprouting in absence of injury [GO:0048669]; digestive tract development [GO:0048565]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; liver development [GO:0001889]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; positive regulation of dendrite development [GO:1900006]; positive regulation of ruffle assembly [GO:1900029]; somite specification [GO:0001757] actin filament [GO:0005884]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic growth cone [GO:0044294]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; terminal web [GO:1990357] actin monomer binding [GO:0003785] APPPPGK;LSYTEAEGER;RTSSQYVASAIAK 3 2.4 0.74624 0.10128 0 4.84639 11.6585 0 0 0 0 0 0 8.70767 0 0 O75129 ASTN2_HUMAN Astrotactin-2 ASTN2 KIAA0634 Homo sapiens (Human) establishment of body hair planar orientation [GO:0048105]; negative regulation of protein localization to cell surface [GO:2000009]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]; protein localization to cell surface [GO:0034394]; protein transport [GO:0015031] cell cortex [GO:0005938]; cell pole [GO:0060187]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; perikaryon [GO:0043204] "calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]" LGEYTLQPLSLQTEETTELGSK;TACPLVDDNK 2 7.3 0.95481 -0.8233 0 0 0 8.89618 0 0 0 0 0 0 0 13.3123 O75131 CPNE3_HUMAN Copine-3 (Copine III) CPNE3 CPN3 KIAA0636 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; positive regulation of cell migration [GO:0030335] azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723] LDNKDLFGK 1 1.7 0.97929 -1.5342 0 0 0 0 0 0 0 0 0 0 0 11.9073 O75132 ZBED4_HUMAN Zinc finger BED domain-containing protein 4 ZBED4 KIAA0637 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" ICERVHR;LVQKVASKIPSPDR;QIIMSHLK;SLKEAMVSR;TCPKEDGDFVSDKIK 5 4.5 0.9766 -2.1811 0 0 0 0 0 0 0 0 0 0 9.87001 10.6218 O75140 DEPD5_HUMAN GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) DEPDC5 KIAA0645 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508] cytosol [GO:0005829]; GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] AQCLTTCRSVR;HYINRNFDR;LAGKKPASEK;LLMILTK;NSTSSTNQNMFCEER;RRWMHTFPVGPSGEAIQIHHQTR;SQAAALLAATVPEQR;TFHKVTLK;VSVDQTATPMLDGTSLGICTGQSMDR 9 7.9 0.97618 -4.4793 0 12.1022 13.8313 7.18854 0 8.46426 0 0 0 0 7.77452 0 O75143 ATG13_HUMAN Autophagy-related protein 13 ATG13 KIAA0652 Homo sapiens (Human) autophagosome assembly [GO:0000045]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein localization to phagophore assembly site [GO:0034497]; regulation of protein lipidation [GO:1903059]; response to mitochondrial depolarisation [GO:0098780] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539] LSLLLKSLLAITR;LSLLLKSLLAITRVTPAYR 2 3.7 0.71084 0.15641 0 5.4803 4.92343 7.8759 4.86181 0 7.11977 6.67059 0 10.2082 0 0 O75144 ICOSL_HUMAN ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275) ICOSLG B7H2 B7RP1 ICOSL KIAA0653 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; defense response [GO:0006952]; hyperosmotic response [GO:0006972]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] YRNRALMSPAGMLR 1 4.6 0.95406 -0.91542 0 0 0 0 10.3021 0 0 0 0 0 0 0 O75145 LIPA3_HUMAN Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) PPFIA3 KIAA0654 Homo sapiens (Human) neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synapse organization [GO:0050808]; synaptic vesicle docking [GO:0016081] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; epididymosome [GO:0098875]; glutamatergic synapse [GO:0098978]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831] AERNNTRLLLEHLECLVSR;ELGHEKDSLQR;ITTLEKR;LDEDSAKSFSRSPSWR;LLSESNER;LNYDRKDLER;LQPEGQTSGSSR;LRQLEAQLEEKNQELQR;NNTRLLLEHLECLVSR 9 8.4 0.95991 -1.0504 0 0 3.98313 11.4209 11.4854 0 10.2471 10.8824 10.6976 13.7754 13.6818 0 O75146 HIP1R_HUMAN Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) HIP1R HIP12 KIAA0655 Homo sapiens (Human) actin filament organization [GO:0007015]; clathrin coat assembly [GO:0048268]; digestive system development [GO:0055123]; endocytosis [GO:0006897]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; postsynapse organization [GO:0099173]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of endocytosis [GO:0030100]; regulation of gastric acid secretion [GO:0060453] apical plasma membrane [GO:0016324]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone [GO:0098843]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060] "actin filament binding [GO:0051015]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124]" IILGTHHEK;NSIKNVPARVLSR;QDHQLDKK;QKALVDNEQLR;TVNERAANVVASTK 5 5.1 0.9741 -3.7954 13.0013 10.0046 10.9547 0 0 0 0 10.1058 0 0 0 0 O75147 OBSL1_HUMAN Obscurin-like protein 1 OBSL1 KIAA0657 Homo sapiens (Human) cardiac myofibril assembly [GO:0055003]; cytoskeleton organization [GO:0007010]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of dendrite morphogenesis [GO:0050775]; protein localization to Golgi apparatus [GO:0034067]; regulation of mitotic nuclear division [GO:0007088] 3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; M band [GO:0031430]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] cytoskeletal anchor activity [GO:0008093] GPILKRLPR;LMYRDRDGGFVLK;LQALGTRRLLQLR 3 1.8 0.97089 -1.3399 6.95315 0 7.47184 0 0 0 0 0 7.54867 0 0 0 O75150 BRE1B_HUMAN E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) RNF40 BRE1B KIAA0661 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] HULC complex [GO:0033503]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] LAERLEQRQACEDELR;QAEEQIEHLQRK;VVEASDRLQRR 3 3.9 0.96152 -1.0669 3.99792 0 0 0 8.73237 0 9.56963 0 0 0 0 0 O75151 PHF2_HUMAN Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) PHF2 CENP-35 KIAA0662 Homo sapiens (Human) chromatin remodeling [GO:0006338]; liver development [GO:0001889]; negative regulation of rDNA heterochromatin formation [GO:0061188]; protein demethylation [GO:0006482]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K9 demethylase activity [GO:0032454]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] IPKPPKPPKPPRPPKTLK;LDSAAYK;MPKPSKIPKPPKPPKPPRPPKTLK;QLPPHLVQGAKILNGAFRSWTK 4 4.8 0.91679 -0.41096 0 0 9.67782 8.23419 0 0 0 0 6.70901 0 4.83582 0 O75152 ZC11A_HUMAN Zinc finger CCCH domain-containing protein 11A ZC3H11A KIAA0663 ZC3HDC11A Homo sapiens (Human) poly(A)+ mRNA export from nucleus [GO:0016973] nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA binding [GO:0003723] TLEEIKSK;TVVRTVTLSTKQGEEPLVR;VGEIHVK;VNKVGEIHVKTLEEILLER;VNVKPSVVKVVSSPKLAPK 5 8 0.98039 -1.666 0 0 0 0 10.1445 0 5.69058 0 8.49133 8.73904 6.84398 0 O75153 CLU_HUMAN Clustered mitochondria protein homolog CLUH KIAA0664 Homo sapiens (Human) intracellular distribution of mitochondria [GO:0048312]; mitochondrion organization [GO:0007005] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] mRNA binding [GO:0003729] ITLLREISLKTGIQVLLK;LLNGDCPESLKK;SVEGLQEGSVLR;VVEEPYTVR 4 3.9 0.89684 -0.25217 0 11.9676 8.70325 0 6.88886 0 0 0 0 4.67027 0 0 O75154 RFIP3_HUMAN Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) RAB11FIP3 ARFO1 KIAA0665 Homo sapiens (Human) cell division [GO:0051301]; early endosome to recycling endosome transport [GO:0061502]; endocytic recycling [GO:0032456]; Golgi to plasma membrane protein transport [GO:0043001]; negative regulation of adiponectin secretion [GO:0070164]; positive regulation of cilium assembly [GO:0045724]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to cilium [GO:0061512]; protein localization to cleavage furrow [GO:1905345]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] calcium ion binding [GO:0005509]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] AVFDALDGDGDGFVR;GRSSSMGLQEYHSRAR;LSHERHQFQRDK;QKELLCKMER;SLFSTAFSESLAAEISSVSR 5 9.7 0.97459 -1.3865 0 0 7.35746 0 4.68991 4.31904 12.1476 0 0 6.2946 9.72371 0 O75155 CAND2_HUMAN Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2) CAND2 KIAA0667 TIP120B Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] cytosol [GO:0005829]; nucleus [GO:0005634] TBP-class protein binding [GO:0017025] LVLVNPSFLLPR;LVLVNPSFLLPRLRK;QLAAGRPHTRSTVITAVK;VVKMLLRLLEDK 4 3.6 0.96439 -1.1756 7.94878 0 2.82644 13.4902 13.3787 13.282 13.2579 3.37518 14.3 13.0717 13.0254 0 O75157 T22D2_HUMAN TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) TSC22D2 KIAA0669 TILZ4 Homo sapiens (Human) negative regulation of cell cycle [GO:0045786]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970] NPSTAFYQAFHLNTLKESK 1 2.4 0.91597 -0.43271 0 0 0 0 0 0 0 0 9.85916 0 0 0 O75159 SOCS5_HUMAN Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5) SOCS5 CIS6 CISH5 CISH6 KIAA0671 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; vascular endothelial cell response to fluid shear stress [GO:0097699] cytosol [GO:0005829] epidermal growth factor receptor binding [GO:0005154]; receptor tyrosine kinase binding [GO:0030971] DSYSRHAPWGGK;EYHYKQK;TVGSRSLR 3 5 0.96651 -1.2732 0 0 0 0 10.6444 0 0 0 0 7.2738 8.00276 0 O75161 NPHP4_HUMAN Nephrocystin-4 (Nephroretinin) NPHP4 KIAA0673 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; flagellated sperm motility [GO:0030317]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of bicellular tight junction assembly [GO:1903348]; protein localization to ciliary transition zone [GO:1904491]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual behavior [GO:0007632] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; non-motile cilium [GO:0097730]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; photoreceptor distal connecting cilium [GO:0120206]; ribbon synapse [GO:0097470] structural molecule activity [GO:0005198] GVQDLHVGVRPLRAGSR;QVESGTLR;TVYFTFQFYRFPPATTPR 3 3 0.9556 -0.84154 0 0 10.0399 6.27398 10.1169 0 7.15714 0 0 0 0 0 O75164 KDM4A_HUMAN Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) KDM4A JHDM3A JMJD2 JMJD2A KIAA0677 Homo sapiens (Human) apoptotic chromosome condensation [GO:0030263]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; regulation of gene expression [GO:0010468]; response to nutrient levels [GO:0031667] chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me2/H3K36me3 demethylase activity [GO:0140681]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; methylated histone binding [GO:0035064]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] HKNGRFYQCEVVR;QAVLCSCRKDMVK 2 2.4 0.88808 -0.18369 0 8.15916 0 0 0 10.9949 0 0 0 0 0 0 O75165 DJC13_HUMAN DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) DNAJC13 KIAA0678 RME8 Homo sapiens (Human) endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of early endosome to recycling endosome transport [GO:1902954] azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] DMFEKVNKAYEFLCTK;ENGLEVLQEAFSR;EVEKFAKEK;ISPRHSEPVK;LILFLNKLILNK;SLAGMLTPYVARK;YAGYPMLIR 7 3.7 0.98089 -1.7999 0 0 0 10.1022 8.29223 0 10.0153 12.8654 10.241 0 0 3.17803 O75167 PHAR2_HUMAN Phosphatase and actin regulator 2 PHACTR2 C6orf56 KIAA0680 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036] plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] AGSSHSKK;LSLRPTVAELQAR;NILQRTSEEERQEIR;TTLYSGTGLSVNR 4 8.7 0.94184 -0.59711 0 0 0 0 0 6.81365 0 0 0 10.1189 0 0 O75170 PP6R2_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) PPP6R2 KIAA0685 PP6R2 SAPS2 Homo sapiens (Human) regulation of signal transduction [GO:0009966] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634] protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888] DFHQLLLNPPK;HIGTSALMDLLLR;LVELIHPSQDEDR;TEEAVGR 4 4.6 0.27574 0.25508 9.7736 9.90781 0 7.07767 8.42991 7.5131 9.82655 10.7563 10.2716 12.3839 0 8.50303 O75173 ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) ADAMTS4 KIAA0688 UNQ769/PRO1563 Homo sapiens (Human) extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear speck [GO:0016607] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; zinc ion binding [GO:0008270] CMVCGGDGSGCSK;FDKCMVCGGDGSGCSK;LTCQAQALGYYYVLEPR 3 3.9 0.91735 -0.40119 0 0 0 0 0 6.86381 0 0 0 7.61279 0 4.90463 O75175 CNOT3_HUMAN CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) CNOT3 KIAA0691 LENG2 NOT3 Homo sapiens (Human) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829] CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] RHIEKHR;STDSEVSQSPAK;YLEDRDLQ 3 3.6 0.97262 -2.6218 0 0 0 0 0 0 11.4111 0 11.4798 0 0 0 O75179 ANR17_HUMAN Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723] GADVNAPPVPSSR;GHLEMVR;ISSCSDESSNSNSSR;ITPLMAAFRKGHVK;SLAEACSEGDVNAVRKLLIEGR;TPLMKAAR 6 3 0.95279 -0.76835 0 0 0 5.17592 8.08199 10.7212 0 10.8777 0 4.30772 9.42116 0 O75185 AT2C2_HUMAN Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2) ATP2C2 KIAA0703 SPCA2 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; mammary gland epithelium development [GO:0061180]; manganese ion transport [GO:0006828]; positive regulation of calcium ion import [GO:0090280]; protein localization to plasma membrane [GO:0072659] basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] EFSNVSVGK;GESTWAGRAGLGVEPVDK;LAHGWNEFVADNSEPVWKK;VTALPPK 4 5.4 0.97816 -1.5072 6.74672 8.62062 0 0 0 0 0 0 0 0 0 0 O75190 DNJB6_HUMAN DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) DNAJB6 HSJ2 MRJ MSJ1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; chaperone-mediated protein folding [GO:0061077]; chorio-allantoic fusion [GO:0060710]; chorion development [GO:0060717]; extracellular matrix organization [GO:0030198]; intermediate filament organization [GO:0045109]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; regulation of cellular response to heat [GO:1900034]; regulation of protein localization [GO:0032880]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] SISTSTK 1 2.1 0.90965 -0.31755 0 8.67342 0 0 0 0 0 0 0 0 0 0 O75192 PX11A_HUMAN Peroxisomal membrane protein 11A (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28) (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (Protein PEX11 homolog alpha) (PEX11-alpha) PEX11A PEX11 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165] peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] protein homodimerization activity [GO:0042803] DLYEISLQMK;VIYFICDTILWVRSVGLTSGINKEK;VTCDRAK;WRTRAAHHYYYSLLLSLVR 4 24.7 0.97324 -2.4919 0 0 9.35012 0 10.1683 0 0 0 0 0 12.2847 0 O75197 LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) LRP5 LR3 LRP7 Homo sapiens (Human) adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; nervous system development [GO:0007399]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] coreceptor activity [GO:0015026]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] AFMDGTNCMTLVDKVGR;DNGGCSHICIAK;LDGQFRQVLVWR;LYWADAK 4 3 0.95584 -0.85198 0 0 0 8.88084 4.08772 9.06894 0 0 0 8.8867 9.06813 0 O75208 COQ9_HUMAN "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142] lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] MAAAAVSGALGRAGWR;MLIPYIEHWPR;NLTGLNQRR;VLEEEQKLVQLGQAEKR 4 16.7 0.98049 -1.6096 0 0 0 0 0 0 0 0 0 12.4625 13.1625 12.629 O75223 GGCT_HUMAN Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) GGCT C7orf24 CRF21 Homo sapiens (Human) release of cytochrome c from mitochondria [GO:0001836] cytosol [GO:0005829]; extracellular exosome [GO:0070062] gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803] AIEPNDYTGK;ENGLPLEYQEK;ENGLPLEYQEKLK 3 12.2 0.95494 -0.79002 0 0 10.5476 0 0 0 0 0 13.1258 11.6188 0 0 O75251 NDUS7_HUMAN "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Homo sapiens (Human) "aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; respiratory chain complex I [GO:0045271]; synaptic membrane [GO:0097060] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; protease binding [GO:0002020]; quinone binding [GO:0048038]" LDDLVNWAR 1 4.2 0.91119 -0.32664 0 0 0 9.42696 0 0 10.4176 0 0 0 0 0 O75290 Z780A_HUMAN Zinc finger protein 780A ZNF780A Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VFSLPTQLNRHKNIHTGEK 1 3 0.44862 0.19174 0 0 0 0 0 0 8.43817 0 0 0 0 0 O75306 NDUS2_HUMAN "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" NDUFS2 Homo sapiens (Human) "aerobic respiration [GO:0009060]; cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] "4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]" APGFAHLAGLDKMSK 1 3.2 0.98028 -1.5995 0 0 0 0 0 0 0 0 0 9.93595 0 0 O75311 GLRA3_HUMAN Glycine receptor subunit alpha-3 GLRA3 Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; protein homooligomerization [GO:0051260] dendrite [GO:0030425]; glycine-gated chloride channel complex [GO:0016935]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888] AKKIDTISR;DLRYCTK;VNIFLRQK 3 5.2 0.97294 -2.8595 0 0 0 0 0 0 0 0 0 11.6914 0 0 O75317 UBP12_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin specific peptidase 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12) USP12 UBH1 USP12L1 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; metal ion binding [GO:0046872] QEAHKRMK;VGVIPPK;YTKLSYRVVFPLELR 3 8.1 0.97629 -1.487 0 0 0 0 0 10.3688 0 0 0 0 0 0 O75319 DUS11_HUMAN RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) DUSP11 PIR1 Homo sapiens (Human) protein dephosphorylation [GO:0006470]; RNA processing [GO:0006396] fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phosphatase activity [GO:0016791]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723] HHARLIFCIFSR;LECSGTISTHSKFCFPGSRR;RSPASASQVAGTTGAR 3 20.8 0.85085 -0.074413 0 0 0 0 0 8.40075 0 0 8.72618 0 10.0545 0 O75323 NIPS2_HUMAN Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence) NIPSNAP2 GBAS Homo sapiens (Human) mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oxidative phosphorylation [GO:0006119]; positive regulation of high voltage-gated calcium channel activity [GO:1901843] mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein-macromolecule adaptor activity [GO:0030674] ENKEFLEFRK 1 3.5 0.9559 -0.98417 0 0 0 0 0 0 0 0 0 11.58 0 0 O75325 LRRN2_HUMAN Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) LRRN2 GAC1 LRRN5 UNQ256/PRO293 Homo sapiens (Human) cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] signaling receptor activity [GO:0038023] FALVNLPELTK 1 1.5 0.795 0.015303 0 0 0 0 0 0 0 0 0 4.96088 0 0 O75326 SEM7A_HUMAN Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) SEMA7A CD108 SEMAL Homo sapiens (Human) axon extension [GO:0048675]; axon guidance [GO:0007411]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; olfactory lobe development [GO:0021988]; osteoblast differentiation [GO:0001649]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage cytokine production [GO:0060907]; regulation of inflammatory response [GO:0050727]; regulation of synapse maturation [GO:0090128]; semaphorin-plexin signaling pathway [GO:0071526] external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] chemorepellent activity [GO:0045499]; integrin binding [GO:0005178]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] TVNIGSTKGSCLDKR;VEPMGPLKTPLFHSK 2 4.5 0.95417 -0.88794 0 0 0 10.1887 0 0 0 0 9.55069 0 0 0 O75330 HMMR_HUMAN Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) HMMR IHABP RHAMM Homo sapiens (Human) hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; spindle [GO:0005819] cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540] LENSSLQEKAAK;LVSIEKEK;MLLDLQTKSALKETEIK;NLFEEELK;NLFEEELKQTLDELDKLQQK 5 7.9 0.97993 -1.5482 0 0 0 0 0 0 12.6199 0 9.83476 0 0 0 O75333 TBX10_HUMAN T-box transcription factor TBX10 (T-box protein 10) TBX10 TBX7 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASASTSK;GAQWMRQIVSFDK 2 5.2 0.82582 -0.020048 0 10.8974 10.3208 9.36457 10.3544 9.45216 0 0 9.87794 0 0 0 O75335 LIPA4_HUMAN Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4) PPFIA4 KIAA0897 Homo sapiens (Human) synapse organization [GO:0050808] cell surface [GO:0009986]; cytosol [GO:0005829]; presynaptic active zone [GO:0048786]; synapse [GO:0045202] AERNNTRLLLEHLECLVSR;HLQELLEVAEQK;ITTLEKR;LGTQAEKDR;LLSESNER;LSEEIEK;MVDSFHRTSLQYGIMCLKR;NNTRLLLEHLECLVSR 8 6.8 0.9674 -1.2948 0 0 12.3397 0 0 0 0 0 9.09183 2.28995 5.72778 0 O75335 LIPA4_HUMAN Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4) PPFIA4 KIAA0897 Homo sapiens (Human) synapse organization [GO:0050808] cell surface [GO:0009986]; cytosol [GO:0005829]; presynaptic active zone [GO:0048786]; synapse [GO:0045202] GSAADVR;LGTQAEKDR;MVDSFHRTSLQYGIMCLKR 3 5.1 0.5889 0.17881 7.69683 0 0 0 7.142 0 0 0 0 0 0 0 O75339 CILP1_HUMAN Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] CILP UNQ602/PRO1188 Homo sapiens (Human) negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] EIALGRCFDGTSDGSSR 1 1.4 0.81105 -0.014435 0 0 0 0 0 0 0 0 5.54776 0 0 0 O75340 PDCD6_HUMAN Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) PDCD6 ALG2 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] QALSGFGYR;TYDRDNSGMIDKNELK;YITDWQNVFRTYDR 3 18.3 0.93568 -0.52036 6.78555 0 0 8.43475 6.18462 0 10.6803 0 0 0 0 0 O75342 LX12B_HUMAN "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] "arachidonate 12(R)-lipoxygenase activity [GO:0106237]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 8(R)-lipoxygenase activity [GO:0047677]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleate 9S-lipoxygenase activity [GO:1990136]; lyase activity [GO:0016829]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" DDSLAVWNALEK;LGPMALAFK;TVPELIR 3 4 0.8755 -0.12167 0 0 0 0 0 0 10.0849 0 0 0 0 10.8612 O75343 GCYB2_HUMAN Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) GUCY1B2 Homo sapiens (Human) cGMP-mediated signaling [GO:0019934]; response to oxygen levels [GO:0070482] "cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; metal ion binding [GO:0046872] DFFDIDVIMDILDMNEEVER;KEHVVFLIVQKAHR;LRSLQELEELNMHLSDIAPNDTTRDLILLNQQR;SIVMFGK;VAAGEFK;VERGADGK 6 14.4 0.97325 -2.5591 4.16519 12.118 10.9026 9.20692 0 0 0 0 0 0 0 11.286 O75344 FKBP6_HUMAN Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) FKBP6 FKBP36 Homo sapiens (Human) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytoplasm [GO:0005737]; cytosol [GO:0005829]; synaptonemal complex [GO:0000795] FK506 binding [GO:0005528]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802] AQKEQPFNHDINNELK;QNRFYDAK;VAATEREFGNYLFRQNR 3 11.6 0.96385 -1.1815 0 0 0 0 0 9.54857 0 0 9.0247 0 0 0 O75346 ZN253_HUMAN Zinc finger protein 253 (Bone marrow zinc finger 1) (BMZF-1) (Zinc finger protein 411) ZNF253 BMZF1 ZNF411 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YEECRHDNLQLKK 1 2.6 0.87024 -0.094434 0 0 0 0 0 0 0 0 0 0 7.72533 0 O75347 TBCA_HUMAN Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) TBCA Homo sapiens (Human) post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730] beta-tubulin binding [GO:0048487]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; tubulin binding [GO:0015631] QAEILQESR 1 8.3 0.0048077 1.5396 13.421 12.1166 4.95327 0 0 0 0 0 0 12.226 0 0 O75351 VPS4B_HUMAN Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) angiogenesis [GO:0001525]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; canonical Wnt signaling pathway [GO:0060070]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; establishment of blood-brain barrier [GO:0060856]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] EGQPSPADEKGNDSDGEGESDDPEK;FTEDFGQEG 2 7.7 0.91797 -0.35874 0 0 0 0 0 0 0 0 7.6851 5.90195 0 0 O75352 MPU1_HUMAN Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) MPDU1 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] AAEADGPLK;GLGLGIVAGSLLVKLPQVFKILGAK;LLVPILLPEK 3 17.8 0.81011 0.006073 0 0 0 0 0 0 10.4441 8.0316 0 5.9956 0 9.20455 O75354 ENTP6_HUMAN Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2) ENTPD6 CD39L2 IL6ST2 Homo sapiens (Human) nucleoside diphosphate catabolic process [GO:0009134]; response to calcium ion [GO:0051592]; response to magnesium ion [GO:0032026] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] "CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; IDP phosphatase activity [GO:1990003]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]" QPQHGPWQTR;VAKVAYPLGLCVGVFIYVAYIK;VSEVLQNR;VSGQKAAASLHELCAAR 4 12.2 0.98156 -1.5895 0 0 11.079 0 0 9.36302 0 7.30561 10.238 0 0 0 O75355 ENTP3_HUMAN Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6) ENTPD3 CD39L3 Homo sapiens (Human) nucleoside diphosphate catabolic process [GO:0009134]; nucleoside triphosphate catabolic process [GO:0009143] plasma membrane [GO:0005886] apyrase activity [GO:0004050]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] ALYRTPTIIALVVLLVSIVVLVSITVIQIHK;VKGQVPSHLHGSTPIHLGATAGMRLLR 2 11 0.95733 -1.0295 0 0 0 0 10.4472 0 0 0 0 0 5.81276 0 O75362 ZN217_HUMAN Zinc finger protein 217 ZNF217 ZABC1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] histone deacetylase complex [GO:0000118]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" ECSYCGKFFR;GITSLLPQDCVYPSQALPPKPR;TSVSPAPDKTKRPETK 3 4.6 0.97363 -1.4153 0 0 0 0 0 8.19923 0 0 0 0 0 9.81485 O75363 BCAS1_HUMAN Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) BCAS1 AIBC1 NABC1 Homo sapiens (Human) myelination [GO:0042552] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] DPTLLPPETGGAGGEAPSKPK;SPTTSADLKSDK 2 5.7 0.9647 -1.1671 0 0 0 0 0 0 0 7.35553 0 0 0 0 O75365 TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) PTP4A3 PRL3 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; endothelial cell migration [GO:0043542]; Notch signaling pathway [GO:0007219]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular permeability [GO:0043117]; regulation of DNA-templated transcription [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" MARMNRPAPVEVSYKHMR 1 10.4 0.50664 0.18791 0 8.74843 0 0 0 0 0 0 0 0 0 0 O75366 AVIL_HUMAN Advillin (p92) AVIL Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" IGVIEGDK;QGGVASGMK 2 2.1 0.95334 -0.73116 11.2268 0 0 0 0 0 0 0 0 0 10.1834 0 O75367 H2AY_HUMAN Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205) MACROH2A1 H2AFY Homo sapiens (Human) "DNA repair [GO:0006281]; epigenetic regulation of gene expression [GO:0040029]; establishment of protein localization to chromatin [GO:0071169]; heterochromatin formation [GO:0031507]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein localization to chromosome, telomeric region [GO:1904815]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of response to oxidative stress [GO:1902883]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of response to oxidative stress [GO:1902884]; regulation of lipid metabolic process [GO:0019216]; regulation of NAD metabolic process [GO:1902688]; regulation of oxidative phosphorylation [GO:0002082]; regulation of response to oxidative stress [GO:1902882]; sex-chromosome dosage compensation [GO:0007549]; transcription initiation-coupled chromatin remodeling [GO:0045815]" "Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; sex chromatin [GO:0001739]; site of DNA damage [GO:0090734]" ADP-D-ribose binding [GO:0072570]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; enzyme binding [GO:0019899]; nucleosomal DNA binding [GO:0031492]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; rDNA binding [GO:0000182]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976] AASADSTTEGTPADGFTVLSTK;AGVIFPVGR;LEAIITPPPAK;NGPLEVAGAAVSAGHGLPAK;QTAAQLILK;SIAFPSIGSGR 6 22.2 0 8.5999 12.3199 11.7645 12.3389 9.60999 11.5566 10.0462 11.4745 14.8737 14.633 11.8174 0 11.0049 O75368 SH3L1_HUMAN Adapter SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein 1) SH3BGRL Homo sapiens (Human) positive regulation of cytoplasmic translational initiation [GO:1904690]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] protein-RNA adaptor activity [GO:0140517]; SH3 domain binding [GO:0017124]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ENNAVYAFLGLTAPPGSK 1 15.8 0.81341 -0.016198 0 0 11.9855 0 0 0 0 0 0 0 0 0 O75369 FLNB_HUMAN Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to type II interferon [GO:0071346]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] AAGSGELGVTMK;ADIEMPFDPSK;AEGPGLSK;AGGPGLER;AGLAPLEVR;AGPGTLSVTIEGPSK;APLNVQFNSPLPGDAVK;APSGRDEPCLLKR;AYGPGLEK;DAGYGGISLAVEGPSK;DGTCTVTYLPTLPGDYSILVK;EAFTNKPNVFTVVTR;FADEHVPGSPFTVK;FNDEHIPESPYLVPVIAPSDDAR;FVPQEMGVHTVSVK;GAGIGGLGITVEGPSESK;GEAGVPAEFSIWTR;GLEELVK;HVGNQQYNVTYVVK;IAGPGLGSGVR;IFAQDGEGQR;IFFAGDTIPK;IKLNGLENRVEVGK;IQQNTFTR;IQQNTFTRWCNEHLK;LDVTILSPSR;LIALLEVLSQKRMYR;LLGWIQNK;LPNNHIGISFIPR;LVSIDSK;LVSPGSANETSSILVESVTR;RLTVMSLQESGLKVNQPASFAIR;SADFVVESIGSEVGSLGFAIEGPSQAK;SPFEVQVGPEAGMQK;SPFEVSVDK;SPFTVGVAAPLDLSK;TATPEIVDNKDGTVTVR;TFEMSDFIVDTR;TGEEVGFVVDAK;VLFASQEIPASPFR;VLPTYDASK;VLQSFTVDSSK;VNQPASFAIR;VNQPASFAIRLNGAK;VQAQGPGLK;VSYFPTVPGVYIVSTK;VTASGPGLSSYGVPASLPVDFAIDAR;VTEAEIVPMGK;VTEAEIVPMGKNSHCVR;VTSKGAGLSKAFVGQK;YADEEIPR;YGGPNHIVGSPFK 52 25.5 0 80.251 12.736 13.449 13.6946 12.0266 12.5947 11.6922 15.264 15.5471 15.4209 15.1573 14.9266 12.3597 O75369 FLNB_HUMAN Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to type II interferon [GO:0071346]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] AAGSGELGVTMK;ADIEMPFDPSK;AEGPGLSK;AGLAPLEVR;APLNVQFNSPLPGDAVK;APSGRDEPCLLKR;AYGPGLEK;DAGYGGISLAVEGPSK;DGTCTVTYLPTLPGDYSILVK;EAFTNKPNVFTVVTR;FADEHVPGSPFTVK;GAGIGGLGITVEGPSESK;GLEELVK;IAGPGLGSGVR;IFAQDGEGQR;IFFAGDTIPK;IKLNGLENRVEVGK;IQQNTFTR;IQQNTFTRWCNEHLK;LDVTILSPSR;LIALLEVLSQKRMYR;LLGWIQNK;LPNNHIGISFIPR;LVSIDSK;SADFVVESIGSEVGSLGFAIEGPSQAK;SPFEVQVGPEAGMQK;SPFEVSVDK;SPFTVGVAAPLDLSK;TATPEIVDNKDGTVTVR;TFEMSDFIVDTR;TGEEVGFVVDAK;VLFASQEIPASPFR;VLPTYDASK;VLQSFTVDSSK;VQAQGPGLK;VQFHTGSR;VSYFPTVPGVYIVSTK;VTASGPGLSSYGVPASLPVDFAIDAR;YADEEIPR 39 22.8 0.92909 -0.48188 0 0 0 0 0 0 0 0 9.04977 0 0 0 O75376 NCOR1_HUMAN Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) NCOR1 KIAA1047 Homo sapiens (Human) chromatin organization [GO:0006325]; locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spindle assembly [GO:0051225] chromatin [GO:0000785]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] AQLSPGIYDDTSAR;EGTRSPRTAHEISLK;FQRVGQRGAGLSATIAR;GMPPLEIVPENIK;NFYFNYKR;QDSLLLLSQRGAEPAEQR;QREQKICQR;SPSPSVR;VEEKEEDK;VELPLYNQPSDTK 10 5 0.97785 -6.0053 0 0 10.341 10.4486 0 11.035 0 0 10.6753 0 12.4739 0 O75379 VAMP4_HUMAN Vesicle-associated membrane protein 4 (VAMP-4) VAMP4 Homo sapiens (Human) "endocytic recycling [GO:0032456]; Golgi ribbon formation [GO:0090161]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle-mediated transport in synapse [GO:0099003]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] AIMALVAAILLLVIIILIVMK;AIMALVAAILLLVIIILIVMKYRT;IKAIMALVAAILLLVIIILIVMK 3 18.4 0.22402 0.31337 0 0 0 0 6.34124 0 0 0 0 6.78293 0 0 O75381 PEX14_HUMAN Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) PEX14 Homo sapiens (Human) "cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein binding [GO:0032091]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003]" cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein transmembrane transporter activity [GO:0008320]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714] EDEEDEEDDDVSHVDEEDCLGVQR 1 6.4 0.71099 0.15634 0 0 5.36622 0 0 0 0 0 0 6.05396 0 0 O75382 TRIM3_HUMAN Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031] cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GEFTNLQGVSAASSGR;KTMEFYCEACETAMCGECR;MKTMEFYCEACETAMCGECR;TMEFYCEACETAMCGECR 4 5.8 0.084507 0.38675 0 13.7172 0 6.98846 0 0 0 0 0 7.83219 4.69254 0 O75385 ULK1_HUMAN Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) ULK1 KIAA0722 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axon extension [GO:0048675]; cellular response to nutrient levels [GO:0031669]; cellular response to stress [GO:0033554]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection development [GO:0031175]; neuron projection regeneration [GO:0031102]; peptidyl-serine phosphorylation [GO:0018105]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of macroautophagy [GO:0016241]; regulation of protein lipidation [GO:1903059]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; omegasome membrane [GO:1903349]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase binding [GO:0051020]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] LQRFFLDK 1 0.8 0.94135 -0.60099 0 0 0 0 0 0 0 0 0 0 7.3753 0 O75387 LAT3_HUMAN Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) SLC43A1 LAT3 PB39 POV1 Homo sapiens (Human) amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; L-leucine transport [GO:0015820]; L-valine transmembrane transport [GO:1903785]; negative regulation of amino acid transport [GO:0051956]; negative regulation of L-leucine import across plasma membrane [GO:1905533]; neutral amino acid transport [GO:0015804] apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; podocyte foot [GO:0098846] amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304]; neutral L-amino acid transmembrane transporter activity [GO:0015175] APTLQQAYRRR 1 2 0.96113 -1.059 0 0 0 0 0 0 0 0 0 0 0 11.0186 O75390 CISY_HUMAN "Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)" CS Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; tricarboxylic acid cycle [GO:0006099] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] citrate (Si)-synthase activity [GO:0004108]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] DILADLIPK;IVPNVLLEQGK;LPCVAAK 3 5.8 0.012579 0.924 12.0446 12.8948 11.4055 0 9.12089 9.19577 11.3158 11.0551 12.5665 9.90417 9.98299 11.7977 O75391 SPAG7_HUMAN Sperm-associated antigen 7 SPAG7 Homo sapiens (Human) nucleus [GO:0005634] nucleic acid binding [GO:0003676] MADLLGSILSSMEKPPSLGDQETRRK 1 11.5 0.87401 -0.10544 0 0 0 0 0 0 0 0 0 0 0 7.54959 O75394 RM33_HUMAN "Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)" MRPL33 C2orf1 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] LTLLHYDPVVKQR 1 20 0.92352 -0.44902 0 0 0 0 7.10003 0 0 0 0 0 0 0 O75396 SC22B_HUMAN Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) SEC22B SEC22L1 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of autophagosome assembly [GO:1902902]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle fusion with Golgi apparatus [GO:0048280]" endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] SNAP receptor activity [GO:0005484] ANNLSSLSKKYR;GEALSALDSKANNLSSLSK 2 10.2 0.87289 -0.1086 0 0 10.4255 0 0 0 0 10.9954 0 0 0 0 O75398 DEAF1_HUMAN Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) DEAF1 SPN ZMYND5 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; embryonic skeletal system development [GO:0048706]; germ cell development [GO:0007281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASSKDWKR;DEDSEEDADSEAERETPR;EQSCVNCGREAMSECTGCHK;TLFEQAKHASTYR 4 10.4 0.9746 -2.3825 0 0 0 0 0 5.68991 0 5.53387 12.2592 0 0 0 O75400 PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 Homo sapiens (Human) "cell division [GO:0051301]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]" membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] RNA binding [GO:0003723] KRNWEALK;LEIYEDVLFFLSK;LSGSSLCSGSWVSADGFLR;SGSDSDDDDSHSK;SNLHAMIK;TLLEQLDDDQ 6 7.4 0.97696 -2.2143 12.407 0 9.8244 0 0 0 0 0 6.8166 7.26791 7.41083 0 O75409 HYPM_HUMAN Huntingtin-interacting protein M (Histone H2A.P) (Huntingtin yeast partner M) H2AP CXorf27 HYPM Homo sapiens (Human) heterochromatin formation [GO:0031507] nucleosome [GO:0000786]; nucleus [GO:0005634] protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] VGLEASNNGSMRNTSQDRER 1 17.1 0.46278 0.19077 0 0 0 0 0 0 0 0 0 0 0 8.9151 O75410 TACC1_HUMAN Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) TACC1 KIAA1103 Homo sapiens (Human) cell division [GO:0051301]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634] nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975] SKLRKPKPVPLR;SRLITTTEQVKFLCFLLSGCK;TSMTSQK 3 4.9 0.81163 0.0019584 0 0 0 8.47853 0 0 0 0 8.48345 0 6.99887 0 O75414 NDK6_HUMAN Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) NME6 Homo sapiens (Human) apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of cell growth [GO:0030308]; negative regulation of mitotic nuclear division [GO:0045839]; UTP biosynthetic process [GO:0006228] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] TLWFQPAER 1 5.5 0.84591 -0.065428 0 0 0 0 7.91319 0 0 0 0 0 0 0 O75417 DPOLQ_HUMAN DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] POLQ POLH Homo sapiens (Human) base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; error-prone translesion synthesis [GO:0042276]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; replication fork processing [GO:0031297]; somatic hypermutation of immunoglobulin genes [GO:0016446] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; damaged DNA binding [GO:0003684]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; RNA-directed DNA polymerase activity [GO:0003964]; single-stranded DNA helicase activity [GO:0017116] DAYYFSLQK;DAYYFSLQKEQK;ELLEVMDQLRR;GLTEREAAALIVEEAR;IRSLTSSK;KWCEKLADIIAR;LKALHPLPGLILEWRR;LTFGIQRELCDLVR;MIEPESVGDDLR;NSGPFAK;QLETFHSTFK;SLVQQNSMNSFQKECHIPFPAEQHPLGATK;TGTYTTNK 13 6 0.97416 -3.8048 8.8535 0 12.1052 0 7.63539 10.5421 12.7648 12.7247 12.7423 8.61883 11.6097 12.6234 O75420 GGYF1_HUMAN GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) GIGYF1 CDS2 PERQ1 PP3360 Homo sapiens (Human) insulin-like growth factor receptor signaling pathway [GO:0048009] cytosol [GO:0005829]; protein-containing complex [GO:0032991] SASPDGGPRSAGWR 1 1.4 0.8866 -0.18246 0 0 0 0 0 0 0 0 0 0 9.99704 0 O75425 MSPD3_HUMAN Motile sperm domain-containing protein 3 MOSPD3 Homo sapiens (Human) heart development [GO:0007507] cytoplasm [GO:0005737]; membrane [GO:0016020] VLCTAPAK 1 3.4 0.91707 -0.41251 0 0 0 0 0 0 0 0 0 0 0 9.92383 O75426 FBX24_HUMAN F-box only protein 24 FBXO24 FBX24 Homo sapiens (Human) protein ubiquitination [GO:0016567] ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] GGQGPRR;YGQLGTGDK 2 2.6 0.91584 -0.39703 0 0 0 0 6.66306 6.30095 0 0 0 0 6.30129 6.7896 O75427 LRCH4_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) LRCH4 LRN LRRN1 LRRN4 Homo sapiens (Human) membrane raft assembly [GO:0001765]; nervous system development [GO:0007399]; positive regulation of toll-like receptor signaling pathway [GO:0034123] plasma membrane [GO:0005886]; PML body [GO:0016605] KDSLLKPGLR;SVPFIHVPSPAVPK 2 3.5 0.78494 0.027504 0 13.5285 15.8683 13.8981 11.4811 13.8593 14.2707 0 14.4415 0 16.0894 0 O75431 MTX2_HUMAN Metaxin-2 (Mitochondrial outer membrane import complex protein 2) MTX2 Homo sapiens (Human) inner mitochondrial membrane organization [GO:0007007]; mitochondrial transport [GO:0006839]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040] cytoplasm [GO:0005737]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401] IEQHYFEDRGK 1 4.2 0.92104 -0.44368 0 0 0 0 0 0 0 0 8.84806 0 7.02403 0 O75436 VP26A_HUMAN Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) VPS26A VPS26 Homo sapiens (Human) "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" "cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982]" DVIVGKIYFLLVRIK;EITGIGPSTTTETETIAK;ELALPGELTQSR;VTIVRRLTDLVK 4 17.4 0.0088496 1.119 0 5.42908 0 4.19038 0 0 0 0 0 0 0 11.9419 O75437 ZN254_HUMAN Zinc finger protein 254 (Bone marrow zinc finger 5) (BMZF-5) (Hematopoietic cell-derived zinc finger protein 1) (HD-ZNF1) (Zinc finger protein 539) (Zinc finger protein 91-like) ZNF254 BMZF5 ZNF539 ZNF91L Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFIWSSTLTK;CEECGKAFIWSSTLTEHKK;SYKCKECGK;TQHKSIYHR 4 7.1 0.95231 -0.72103 8.3062 0 0 0 0 0 0 0 0 8.80597 0 0 O75438 NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) NDUFB1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] GEWQVPR;LTAFRNK 2 13.3 0.9381 -0.57471 0 0 0 0 8.54666 0 0 0 0 10.1821 0 0 O75443 TECTA_HUMAN Alpha-tectorin TECTA Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] extracellular matrix structural constituent [GO:0005201] LFQLGFEREGVRINDR 1 0.7 0.96143 -1.0711 0 0 0 0 0 0 0 0 0 11.8224 0 0 O75445 USH2A_HUMAN Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696] collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022] DRTSPSAPSGMEPPK;EYVLTDGGRR;GITSRSLQIDWVSPR;GVIEKYILK;ISFFINGVEK;TVNGLQPPIKVMTLGRILVK 6 1.5 0.97479 -3.7359 8.38901 8.82302 0 0 0 0 0 9.96038 0 7.02059 11.4602 0 O75448 MED24_HUMAN Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ALLFDISFLMLCHVAQTYGSEVILSESR;IPQVLVKLKK;MKVVNLKQAILQAWK;VVLAITDLSLPLGRQVAAK;VVNLKQAILQAWK 5 7.3 0.95595 -0.98775 0 4.45864 12.3892 7.3328 0 5.01413 0 10.2197 6.10283 0 0 0 O75460 ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 Homo sapiens (Human) "cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine trans-autophosphorylation [GO:1990579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of RNA splicing [GO:0033120]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; response to endoplasmic reticulum stress [GO:0034976]" AIP1-IRE1 complex [GO:1990597]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Ire1 complex [GO:1990332]; IRE1-RACK1-PP2A complex [GO:1990630]; IRE1-TRAF2-ASK1 complex [GO:1990604]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; ADP binding [GO:0043531]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082] EGLRKVMHINVAVETLR;MLERFPNNLPK;QLQFFQDVSDR;WKYPFPK 4 4.7 0.97306 -2.9467 0 12.6463 6.65964 0 0 0 0 0 0 0 9.12285 0 O75469 NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) NR1I2 PXR Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908] chromatin [GO:0000785]; intermediate filament cytoskeleton [GO:0045111]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" KCLESGMKK;MTCEGCK 2 4.7 0.91378 -0.32913 0 0 0 0 0 0 0 5.29157 0 0 0 0 O75469 NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) NR1I2 PXR Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908] chromatin [GO:0000785]; intermediate filament cytoskeleton [GO:0045111]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" GPEANLEVRPK;KCLESGMKK 2 4.8 0.95285 -0.67885 0 0 0 0 0 0 0 9.81524 0 0 0 0 O75473 LGR5_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) LGR5 GPR49 GPR67 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; G protein-coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; inner ear development [GO:0048839]; oocyte differentiation [GO:0009994]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of cell population proliferation [GO:0042127] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888] LGVLLSLPVLLQLATGGSSPRSGVLLR;QTYVWTR;TLSNLKELHFYDNPIQFVGR 3 6.1 0.91575 -0.37256 0 0 0 8.08151 7.25955 0 0 0 0 0 0 0 O75475 PSIP1_HUMAN PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) PSIP1 DFS70 LEDGF PSIP2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; mRNA 5'-splice site recognition [GO:0000395]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; RNA binding [GO:0003723]; supercoiled DNA binding [GO:0097100]; transcription coactivator activity [GO:0003713] GQEEKQPK 1 1.5 0.91403 -0.33804 0 0 0 0 0 0 0 0 0 7.21868 0 0 O75478 TAD2A_HUMAN Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) TADA2A TADA2L KL04P Homo sapiens (Human) chromatin remodeling [GO:0006338]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] EVQDLYETMRRFAR;IDVNKTRK;KIYDFLIR;TADTAIPFHSTDDPPRPTFDSLLSR 4 12.2 0.9795 -1.8518 0 0 0 0 0 9.90614 10.9314 0 0 0 0 0 O75486 SUPT3_HUMAN Transcription initiation protein SPT3 homolog (SPT3-like protein) SUPT3H SPT3 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713] YMFIRDYK;YSHRIGPLSPFTNAYR;YSLGDAR 3 9.5 0.97436 -2.4454 0 0 11.322 0 0 0 0 0 0 0 0 0 O75487 GPC4_HUMAN Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] GPC4 UNQ474/PRO937 Homo sapiens (Human) cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of presynapse assembly [GO:1905606]; regulation of signal transduction [GO:0009966]; synaptic membrane adhesion [GO:0099560]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] coreceptor activity [GO:0015026] ICPQGSTCCSQEMEEK 1 2.9 0.94085 -0.58759 8.49097 0 0 0 0 0 0 0 0 0 0 0 O75493 CAH11_HUMAN Carbonic anhydrase-related protein 11 (CA-RP XI) (CA-XI) (CARP XI) (Carbonic anhydrase-related protein 2) (CA-RP II) (CARP-2) CA11 CARP2 UNQ211/PRO237 Homo sapiens (Human) one-carbon metabolic process [GO:0006730] basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576] hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270] ALNITSLQMHSLR 1 4 0.87285 -0.1042 0 0 0 9.94166 0 0 0 0 0 0 0 11.4489 O75503 CLN5_HUMAN "Bis(monoacylglycero)phosphate synthase CLN5 (BMP synthase CLN5) (EC 2.3.1.-) (Ceroid-lipofuscinosis neuronal protein 5) (Protein CLN5) (Palmitoyl protein thioesterase CLN5) (EC 3.1.2.22) (S-depalmitoylase CLN5) [Cleaved into: Bis(monoacylglycero)phosphate synthase CLN5, secreted form]" CLN5 BMPS Homo sapiens (Human) "brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; neuron maturation [GO:0042551]; positive regulation of GTP binding [GO:1904426]; protein catabolic process [GO:0030163]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775] "bis(monoacylglycero)phosphate synthase activity [GO:0160121]; D-mannose binding [GO:0005537]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]" ITYEEIPLPIR;LAEFGAEFK 2 5.6 0.93017 -0.47627 11.0737 0 9.84059 0 0 0 0 0 0 0 0 5.79678 O75509 TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) TNFRSF21 DR6 UNQ437/PRO868 Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; B cell apoptotic process [GO:0001783]; cellular response to tumor necrosis factor [GO:0071356]; humoral immune response [GO:0006959]; myelination [GO:0042552]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of myelination [GO:0031642]; negative regulation of T cell proliferation [GO:0042130]; neuron apoptotic process [GO:0051402]; oligodendrocyte apoptotic process [GO:0097252]; regulation of oligodendrocyte differentiation [GO:0048713]; T cell receptor signaling pathway [GO:0050852] plasma membrane [GO:0005886] LENSALLTVEPSPQDK;VIEEIPQAEDK 2 4.1 0.81073 -0.014791 0 0 0 0 0 8.67617 0 10.3815 0 0 0 0 O75525 KHDR3_HUMAN "KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)" KHDRBS3 SALP SLM2 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124] LVNQEIEKFQKGEGK 1 4.3 0.84128 -0.045344 0 0 11.8262 0 0 0 7.34474 0 0 0 0 7.90316 O75526 RMXL2_HUMAN "RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)" RBMXL2 HNRNPGT Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; snRNA binding [GO:0017069] AAARDMNGK;DYGHSSVRDDCPLR;GFAFVTFESPADAK;GGGGGPR;VEADRPGK 5 13.3 0.92872 -0.46364 0 0 9.13371 0 0 0 0 0 0 2.79464 6.22699 0 O75528 TADA3_HUMAN Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) TADA3 ADA3 TADA3L Homo sapiens (Human) chromatin organization [GO:0006325]; estrogen receptor signaling pathway [GO:0030520]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713] GLMGPLTELDTKDVDALLK;KEKDQAWK;SVDHLKVCPRYTAVLAR 3 10.2 0.25611 0.27345 0 0 0 9.92361 0 0 8.55378 0 0 7.04832 0 0 O75529 TAF5L_HUMAN TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta) TAF5L PAF65B Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] transcription coactivator activity [GO:0003713] VLTLHIHLDVQPAKR 1 2.5 0.30342 0.25017 0 0 0 0 7.65385 0 0 0 0 0 0 0 O75533 SF3B1_HUMAN Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) SF3B1 SAP155 Homo sapiens (Human) "chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]" B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935] GGDSIGETPTPGASK;IWDPTPSHTPAGAATPGR;KIMKLLLK;LDPFADGGKTPDPK;SLVEIIEHGLVDEQQK;TEILPPFFK 6 6.1 0.91091 -0.28722 12.1525 0 11.0924 0 0 0 3.72279 9.59425 6.75489 9.97985 6.12592 0 O75534 CSDE1_HUMAN Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) CSDE1 D1S155E KIAA0885 NRU UNR Homo sapiens (Human) "CRD-mediated mRNA stabilization [GO:0070934]; IRES-dependent viral translational initiation [GO:0075522]; male gonad development [GO:0008584]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; stress granule assembly [GO:0034063]" CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mCRD-mediated mRNA stability complex [GO:0106002]; P-body [GO:0000932]; plasma membrane [GO:0005886] lncRNA binding [GO:0106222]; mRNA binding [GO:0003729]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613] LTIAFQAK;LTIAFQAKDVEGSTSPQIGDK 2 2.6 0.91698 -0.40968 0 0 0 8.88835 0 0 12.5247 0 0 9.09183 0 0 O75541 ZN821_HUMAN Zinc finger protein 821 ZNF821 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] WALRRQNEPLEVR 1 3.2 0.87027 -0.094434 7.12174 0 0 0 0 0 0 0 0 0 0 0 O75553 DAB1_HUMAN Disabled homolog 1 DAB1 Homo sapiens (Human) adult walking behavior [GO:0007628]; astrocyte differentiation [GO:0048708]; axonogenesis [GO:0007409]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [GO:0021813]; cerebellum structural organization [GO:0021589]; dendrite development [GO:0016358]; Golgi localization [GO:0051645]; hippocampus development [GO:0021766]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; neuron migration [GO:0001764]; positive regulation of neuron differentiation [GO:0045666]; radial glia guided migration of Purkinje cell [GO:0021942]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of synapse maturation [GO:0090128]; small GTPase-mediated signal transduction [GO:0007264]; ventral spinal cord development [GO:0021517] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471] signaling adaptor activity [GO:0035591] DPETEENIYQVPTSQK;GVVAGAR 2 3.9 0.44742 0.1921 0 0 0 0 5.82932 0 0 0 0 11.6476 11.5166 0 O75553 DAB1_HUMAN Disabled homolog 1 DAB1 Homo sapiens (Human) adult walking behavior [GO:0007628]; astrocyte differentiation [GO:0048708]; axonogenesis [GO:0007409]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [GO:0021813]; cerebellum structural organization [GO:0021589]; dendrite development [GO:0016358]; Golgi localization [GO:0051645]; hippocampus development [GO:0021766]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; neuron migration [GO:0001764]; positive regulation of neuron differentiation [GO:0045666]; radial glia guided migration of Purkinje cell [GO:0021942]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of synapse maturation [GO:0090128]; small GTPase-mediated signal transduction [GO:0007264]; ventral spinal cord development [GO:0021517] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471] signaling adaptor activity [GO:0035591] GVVAGAR;QCEQAVYQVPTSQKKEGVYDVPK 2 5.6 0.86588 -0.091958 8.57323 0 0 0 0 0 0 0 0 0 0 0 O75554 WBP4_HUMAN WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) WBP4 FBP21 FNBP21 Homo sapiens (Human) "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] SLDKAKEEEK 1 2.7 0.97325 -1.4169 0 0 0 0 0 0 0 0 0 0 0 10.8514 O75558 STX11_HUMAN Syntaxin-11 STX11 Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] IQRQLEIMGK;TVDYTGQAKAQVR 2 8 0.97867 -1.9729 0 0 0 0 0 6.93109 0 0 0 0 0 12.3711 O75563 SKAP2_HUMAN Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) SKAP2 PRAP RA70 SAPS SCAP2 SKAP55R Homo sapiens (Human) B cell activation [GO:0042113]; negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GAIGLVPK;TVFYYYGSDKDKQQK 2 6.4 0.78393 0.019763 6.25208 0 0 0 0 0 0 0 0 0 7.21257 0 O75564 JERKY_HUMAN Jerky protein homolog JRK JH8 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA binding [GO:0003729] VLYEWFLGK 1 1.6 0.84569 -0.065428 0 0 0 0 0 0 6.72288 5.74932 0 0 0 0 O75570 RF1M_HUMAN "Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)" MTRF1 Homo sapiens (Human) mitochondrial translational termination [GO:0070126] mitochondrion [GO:0005739] "translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]" LYQQIIEKDK;SLNKQDEK 2 4 0.9808 -1.7111 0 0 7.30031 0 0 0 0 0 0 0 0 0 O75578 ITA10_HUMAN Integrin alpha-10 ITGA10 UNQ468/PRO827 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229] external side of plasma membrane [GO:0009897]; integrin alpha10-beta1 complex [GO:0034680]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] CHLGQLAK;EEVVRAAK;LGFFAHKK;LVHNEFFRR 4 2.8 0.97993 -1.8329 0 13.1394 10.4027 0 0 0 12.4327 12.6145 0 10.0953 9.97957 0 O75581 LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; endocytosis [GO:0006897]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] CANGQCIGKHKK;LYWADAK 2 1.2 0.9637 -1.0946 0 0 0 0 0 0 0 0 0 0 0 7.74221 O75582 KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) RPS6KA5 MSK1 Homo sapiens (Human) axon guidance [GO:0007411]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IIDFGFARLKPPDNQPLK;ISGHDTGKLYAMK;LLMKDPK;SAMMKDSPFYQHYDLDLK;TANLTGHAEK 5 8.2 0.97352 -2.4734 0 0 15.4733 0 0 4.2721 6.86555 11.561 0 11.4934 0 9.72151 O75586 MED6_HUMAN Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28) MED6 ARC33 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase activity [GO:0061630] ETTKNVQQTVSAKGPPEK 1 7.3 0.95758 -1.0281 0 0 0 0 0 0 0 0 0 0 0 9.64447 O75592 MYCB2_HUMAN E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of cytoskeleton organization [GO:0051493]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DAIYSDSSSLVTDLK;DLGNKVTSMTFLTGKAVEDLCR;GIPIGMLVLGNKVK;HGTDFLEYKCR;LAECIGKTR;NITINCVK;RVNSGDTEVGSSLLR;SKLTNLQKQVCAHIVQAIR;TVQNSGYGPK;WLQPDSYADPQKTSLILNKDDIR 10 3.1 0.97225 -2.6981 11.1968 0 0 10.4598 7.36571 9.08889 8.61114 0 8.95431 0 8.7172 0 O75593 FOXH1_HUMAN Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2) FOXH1 FAST1 FAST2 Homo sapiens (Human) aorta morphogenesis [GO:0035909]; axial mesoderm development [GO:0048318]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to cytokine stimulus [GO:0071345]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; heart looping [GO:0001947]; hepatocyte differentiation [GO:0070365]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway [GO:0038092]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; secondary heart field specification [GO:0003139]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular trabecula myocardium morphogenesis [GO:0003222] activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; nuclear androgen receptor binding [GO:0050681]; protein domain specific binding [GO:0019904]; R-SMAD binding [GO:0070412]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]" LKLAQIIRQVQAVFPFFR 1 4.9 0.86544 -0.089452 0 0 0 6.00699 0 0 0 0 0 0 0 0 O75594 PGRP1_HUMAN Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; biological process involved in interaction with host [GO:0051701]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; negative regulation of inflammatory response [GO:0050728]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; receptor ligand activity [GO:0048018]; zinc ion binding [GO:0008270] GHRDVQR;NVQHYHMK;TLSPGNQLYHLIQNWPHYR 3 17.3 0.98089 -1.7582 7.163 9.1274 0 10.7775 0 0 11.2343 0 10.9348 0 9.2275 0 O75607 NPM3_HUMAN Nucleoplasmin-3 NPM3 Homo sapiens (Human) chromatin remodeling [GO:0006338]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] AAGTAAALAFLSQESR 1 9 0 26.227 0 11.7181 11.132 8.86388 8.39313 8.63118 9.39553 0 9.76671 7.73451 0 0 O75608 LYPA1_HUMAN Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) LYPLA1 APT1 LPL1 Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; negative regulation of aggrephagy [GO:1905336]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620] ALIDQEVK 1 3.5 0.91584 -0.34526 0 0 12.3365 0 0 0 0 0 0 11.0963 0 0 O75610 LFTY1_HUMAN Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B) LEFTY1 LEFTB LEFTYB UNQ278/PRO317 Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; determination of left/right symmetry [GO:0007368]; heart morphogenesis [GO:0003007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160] LPPNSELVQAVLR;TRPQVVSLPNMR 2 6.8 0.80644 0.011879 0 0 0 0 9.63961 0 0 0 0 0 0 10.4029 O75616 ERAL1_HUMAN "GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1)" ERAL1 HERA Homo sapiens (Human) ribosomal small subunit assembly [GO:0000028] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] KVFPVSRK;SVLLELTAALTEAIPSDTGPAR 2 10.9 0.97192 -1.3479 0 10.2347 10.413 8.51861 0 0 0 0 0 6.36559 8.32773 0 O75618 DEDD_HUMAN Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1) DEDD DEDPRO1 DEFT KE05 Homo sapiens (Human) decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleolus [GO:0005730] DNA binding [GO:0003677] LLRNLMLQALP 1 3.5 0.98019 -1.6516 0 0 0 0 0 0 0 0 0 0 13.7954 0 O75626 PRDM1_HUMAN PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) PRDM1 BLIMP1 Homo sapiens (Human) adaptive immune response [GO:0002250]; aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; maternal placenta development [GO:0001893]; methylation [GO:0032259]; morphogenesis of a branching structure [GO:0001763]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of cell population proliferation [GO:0042127]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; sebum secreting cell proliferation [GO:1990654]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IYSRGELHHFIDGFNEEK 1 2.2 0.81296 -0.015627 0 0 0 0 0 0 0 0 0 0 0 8.84191 O75643 U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 Homo sapiens (Human) "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DLLPYGFAIHHAGMTR;EGSASTEVLR;FYDDAIVSQK;GNIIISTPEK;GRWTELGALDILQMLGR;IVALSSSLSNAK;LEGTRMGDKAQR;LSDSTLK;TGNFQVTELGR;YPPPTELLDLQPLPVSALR 10 5.8 0.050347 0.48105 10.9572 11.2499 10.8805 0 7.81121 0 12.146 11.8631 12.1595 14.5294 15.3586 0 O75648 MTU1_HUMAN Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog) TRMU MTU1 TRMT1 Homo sapiens (Human) tRNA wobble position uridine thiolation [GO:0002143] mitochondrion [GO:0005739] ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA-5-taurinomethyluridine 2-sulfurtransferase [GO:0061708] DKMMECHFR;VCQILDIPFHQVSYVK 2 5.9 0.84994 -0.076197 0 0 0 0 0 0 0 0 11.1808 0 0 0 O75648 MTU1_HUMAN Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog) TRMU MTU1 TRMT1 Homo sapiens (Human) tRNA wobble position uridine thiolation [GO:0002143] mitochondrion [GO:0005739] ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA-5-taurinomethyluridine 2-sulfurtransferase [GO:0061708] DKMMECHFR;LEMVSQDALR;SLSRSTLR 3 12.2 0.97346 -2.4747 0 0 0 10.1483 0 10.5552 0 0 0 0 0 0 O75663 TIPRL_HUMAN TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) TIPRL Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; TOR signaling [GO:0031929] cytosol [GO:0005829] protein phosphatase activator activity [GO:0072542]; protein phosphatase inhibitor activity [GO:0004864] IDPNPADSQK 1 3.7 0.79741 0.014753 0 0 0 0 0 0 0 9.49931 0 0 0 0 O75665 OFD1_HUMAN Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) OFD1 CXorf5 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; nucleus [GO:0005634] alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] ELQQEAERLEKAFR;ENQKGFLMHFLKELAEYHQAK;REIEEQLRAEMCQK 3 4.8 0.95176 -0.67031 0 0 0 0 0 0 0 10.4445 7.28605 0 0 11.4133 O75674 TM1L1_HUMAN TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) TOM1L1 SRCASM Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; protein transport [GO:0015031]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; membrane [GO:0016020] clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130] GAQNDGD;ISKNYNHK 2 3.2 0.96734 -1.3213 0 0 0 0 0 4.82619 0 10.2984 0 0 0 0 O75676 KS6A4_HUMAN Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) RPS6KA4 MSK2 Homo sapiens (Human) inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGGHDAGK;GLLTVDPAK;KIPAPFRPQIRSELDVGNFAEEFTR;MGDEDDDESCAVELR;QAPFLVTLHYAFQTDAK;VSVENFELLK;VYGGEIVLALEHLHKLGIIYR 7 13.6 0.97383 -2.4625 0 0 6.44609 0 0 0 10.5181 7.34509 6.34975 0 6.84097 5.82525 O75679 RFPL3_HUMAN Ret finger protein-like 3 RFPL3 Homo sapiens (Human) innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630] ILQMNPR 1 2.2 0.60153 0.1782 0 0 0 0 8.73816 0 0 0 0 0 0 0 O75688 PPM1B_HUMAN Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) PPM1B PP2CB Homo sapiens (Human) N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] ESDGGAGDLEDPW 1 3.4 0.86289 -0.083169 10.6441 0 0 0 0 0 0 0 0 0 12.4429 0 O75691 UTP20_HUMAN Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; negative regulation of cell population proliferation [GO:0008285]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" "90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; preribosome, small subunit precursor [GO:0030688]; small-subunit processome [GO:0032040]" RNA binding [GO:0003723] EIDPENFK;EIIHRSLLEKLR;ELQNDMTDEK;FMKDKEQSSVLITLLLPFLHR;GQNFHLVVNCFK;HPEKVEGVGQLLFEMCKGVR;IFESRFEKR;KLHIRNFAAESFTFLMR;LLFSFLTLITKLIK;QLIAHLQVFSK;VTKTNCCESSEQIK 11 5.3 0.97234 -2.8058 0 0 10.3687 0 7.21519 0 0 0 11.6677 0 9.32042 5.19338 O75694 NU155_HUMAN Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) NUP155 KIAA0791 Homo sapiens (Human) atrial cardiac muscle cell action potential [GO:0086014]; miRNA processing [GO:0035196]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] ANELLQR;DELFSIALYNWLIQVDLADK;IYAGTPR;LLEVYDQLFKSR;MPSSLLGAAMPASTSAAALQEALENAGR;TEKERMLR;YGGEAQMR 7 6.5 0.97857 -2.118 0 0 12.0447 0 0 0 0 8.03094 8.2054 9.80095 6.16265 0 O75715 GPX5_HUMAN Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5) GPX5 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; lipid metabolic process [GO:0006629] extracellular region [GO:0005576] glutathione peroxidase activity [GO:0004602] SISWDPVKVHDIRWNFEK;TDILAYLKQFKTK 2 14 0.88409 -0.17205 0 0 0 0 0 0 0 8.37125 0 0 3.39136 0 O75717 WDHD1_HUMAN WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) WDHD1 AND1 Homo sapiens (Human) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677] IAAGSSDFLVK;KKQILHGDPLPLTR;LSAFAFK;SICRLAWQPK;STNILDNMGK 5 4.6 0.95961 -1.0429 11.4552 12.4351 12.5313 0 0 0 0 10.6864 11.3852 12.6712 0 9.89376 O75718 CRTAP_HUMAN Cartilage-associated protein CRTAP CASP Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; collagen fibril organization [GO:0030199]; negative regulation of post-translational protein modification [GO:1901874]; protein stabilization [GO:0050821]; spermatogenesis [GO:0007283] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] ELYDFAK;EVLADFQR;QGLPAFR 3 5.5 0.97808 -1.5262 0 0 0 0 0 0 0 0 10.8819 0 0 0 O75746 S2512_HUMAN "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)" SLC25A12 AGC1 ARALAR1 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; response to calcium ion [GO:0051592] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]" LTLADIER;LTVNDFVR;LTVNDFVRDK 3 2.7 0.89118 -0.21058 0 13.5657 0 10.1585 0 0 0 0 11.5487 0 0 0 O75747 P3C2G_HUMAN Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.137) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma) PIK3C2G Homo sapiens (Human) chemotaxis [GO:0006935]; modulation by host of viral process [GO:0044788]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol kinase activity [GO:0052742] SIERATILGFSK 1 0.8 0.88691 -0.18475 0 0 0 0 0 0 11.4308 0 0 0 0 0 O75751 S22A3_HUMAN Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3) SLC22A3 EMTH OCT3 Homo sapiens (Human) cellular detoxification [GO:1990748]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic anion transport [GO:0015711]; organic cation transport [GO:0015695]; purine-containing compound transmembrane transport [GO:0072530]; quaternary ammonium group transport [GO:0015697]; regulation of appetite [GO:0032098]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; presynapse [GO:0098793] monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; toxin transmembrane transporter activity [GO:0019534] GIALPETVDDVEK;GPEPPERR;VGEFGRFQR 3 5.4 0.95316 -0.72695 0 0 0 0 0 0 7.7922 0 7.65191 6.94895 10.1425 7.61971 O75752 B3GL1_HUMAN "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)" B3GALNT1 B3GALT3 UNQ531/PRO1074 Homo sapiens (Human) glycosphingolipid biosynthetic process [GO:0006688]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity [GO:0047273]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" SWWGYEVLTFFLLGQEAEK;VNIHIPEDTNLFFLYRIHLDVCQLR;VTWGEKK 3 15.4 0.8964 -0.24098 12.0305 5.38253 0 0 0 0 0 0 7.32894 0 0 0 O75762 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) TRPA1 ANKTM1 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955] plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421] calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; temperature-gated cation channel activity [GO:0097604] DKKSPLHFAASYGR;SPLHFAASYGR 2 1.3 0.97857 -2.0858 0 0 0 0 0 0 0 0 0 0 9.20154 0 O75771 RA51D_HUMAN DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) RAD51D RAD51L3 Homo sapiens (Human) DNA repair [GO:0006281]; DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; reciprocal meiotic recombination [GO:0007131]; regulation of cell cycle [GO:0051726]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; gamma-tubulin binding [GO:0043015]; single-stranded DNA binding [GO:0003697]" GTAVSTSRLDK 1 3.2 0.97984 -1.5669 0 0 0 0 0 0 0 0 0 11.1341 0 0 O75781 PALM_HUMAN Paralemmin-1 (Paralemmin) PALM KIAA0270 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to electrical stimulus [GO:0071257]; cytoskeleton organization [GO:0007010]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; positive regulation of filopodium assembly [GO:0051491]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; synapse maturation [GO:0060074] apicolateral plasma membrane [GO:0016327]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; dendritic spine [GO:0043197]; filopodium membrane [GO:0031527]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] D3 dopamine receptor binding [GO:0031750] QAEIENK;QLEDERR 2 3.6 0.95881 -1.0401 0 0 0 0 0 0 9.53481 0 0 0 0 0 O75783 RHBL1_HUMAN Rhomboid-related protein 1 (RRP) (EC 3.4.21.105) (Rhomboid-like protein 1) RHBDL1 RHBDL Homo sapiens (Human) proteolysis [GO:0006508]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] FVRYVAYEILPCEVDR 1 3.7 0.91662 -0.42559 6.43771 0 0 0 0 0 7.30506 0 0 0 0 0 O75791 GRAP2_HUMAN GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) GRAP2 GADS GRB2L GRID Homo sapiens (Human) cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784] ASQSSPGDFSISVR 1 4.2 0.89794 -0.23244 0 0 0 0 0 0 0 0 0 0 8.92217 0 O75794 CD123_HUMAN Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32) CDC123 C10orf7 D123 Homo sapiens (Human) eukaryotic translation initiation factor 2 complex assembly [GO:1905143] cytoplasm [GO:0005737] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein folding chaperone [GO:0044183] KWCELIPGAEFRCFVK;TLSDIFLLFK 2 7.7 0.84572 -0.059154 0 8.12939 0 0 0 0 0 8.93292 0 0 0 0 O75795 UDB17_HUMAN UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (UGT2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT) UGT2B17 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] CCLFCFR;GAALSVDIR;LAKTGKK 3 4.3 0.97878 -1.9039 0 0 0 0 9.81868 5.1549 0 0 0 0 0 0 O75800 ZMY10_HUMAN Zinc finger MYND domain-containing protein 10 (Protein BLu) ZMYND10 BLU LUCA12.4 Homo sapiens (Human) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]; protein localization to cilium [GO:0061512] apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293] metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein folding chaperone [GO:0044183] CQNEWYCCR;LHPVCWFLSPGKLQQFEGSR;VPTLVEELIAVEMWK 3 10.1 0.92853 -0.47065 0 0 0 0 0 0 10.5813 0 9.66012 8.66221 0 7.07778 O75807 PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) PPP1R15A GADD34 Homo sapiens (Human) apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; positive regulation of translational initiation in response to stress [GO:0032058]; protein localization to endoplasmic reticulum [GO:0070972]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 1 complex [GO:0000164] protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] SSGSDPR 1 1 0.68164 0.16457 0 0 0 0 0 0 0 0 0 8.89391 0 0 O75815 BCAR3_HUMAN Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) BCAR3 NSP2 SH2D3B UNQ271/PRO308 Homo sapiens (Human) endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; lens morphogenesis in camera-type eye [GO:0002089]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784] HQYTQTAILYEKQLKPFSK;QAVTFEGTDMWEK 2 3.9 0.9172 -0.4215 0 0 0 0 0 6.77676 9.32982 6.42568 5.4526 0 0 0 O75817 POP7_HUMAN Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7) POP7 RPP20 Homo sapiens (Human) rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723] AENREPR;LLDGGAR 2 10 0.97844 -2.1206 0 0 0 0 0 0 0 10.812 0 0 0 0 O75818 RPP40_HUMAN Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1) RPP40 RNASEP1 Homo sapiens (Human) "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; tRNA 5'-leader removal [GO:0001682]" multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] ISWSFKEKKPLK 1 3.3 0.86936 -0.094088 0 0 0 0 0 0 0 0 0 0 0 8.14644 O75820 ZN189_HUMAN Zinc finger protein 189 ZNF189 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLVKHQR;TQETHECDACGEAFNCR 2 3.8 0.96532 -1.1612 0 6.37638 0 0 7.80922 0 0 0 6.55065 0 0 0 O75821 EIF3G_HUMAN Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) EIF3G EIF3S4 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] GFAFISFHR;VTNLSEDTR 2 5.6 0.91393 -0.38047 0 0 12.0893 0 0 0 0 9.25177 8.92982 7.05539 0 0 O75822 EIF3J_HUMAN Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) EIF3J EIF3S1 PRO0391 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743] AAAAAAAGDSDSWDADAFSVEDPVR;DDFTEFGK;DNWDDDDDEK;DNWDDDDDEKK 4 17.1 0 12.631 0 0 0 0 3.64051 0 0 0 0 10.0107 8.75469 0 O75828 CBR3_HUMAN Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) CBR3 SDR21C2 Homo sapiens (Human) cognition [GO:0050890]; phylloquinone catabolic process [GO:0042376]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] 3-keto sterol reductase activity [GO:0000253]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753] GQAAVQQLQAEGLSPR;ILVNACCPGPVKTDMDGKDSIR 2 13.7 0.8654 -0.086939 0 10.3481 0 0 0 0 0 0 0 7.47135 0 0 O75829 CNMD_HUMAN Leukocyte cell-derived chemotaxin 1 (Chondromodulin) [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)] CNMD CHMI LECT1 MYETS1 Homo sapiens (Human) cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; proteoglycan metabolic process [GO:0006029]; skeletal system development [GO:0001501] endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020] IPEVGAVTK;RPHSGPRSNPGAGR 2 6.9 0.95549 -0.85434 0 0 0 0 0 0 0 0 0 0 3.19654 0 O75830 SPI2_HUMAN Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14) SERPINI2 MEPI PI14 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] LVDFQDAK;VTNPDTQEIK 2 4.4 0.92395 -0.44882 0 0 0 10.0622 0 0 0 0 0 0 0 11.2117 O75832 PSD10_HUMAN 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) "apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome regulatory particle assembly [GO:0070682]; protein localization to plasma membrane [GO:0072659]; regulation of transcription by RNA polymerase II [GO:0006357]" cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502] cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; transmembrane transporter binding [GO:0044325] GNLKMIHILLYYK;LLVSQGASIYIENKEEK;TPLQVAKGGLGLILKR 3 20.4 0.95497 -0.9623 9.88414 0 7.7862 0 8.73352 10.5658 0 0 0 0 9.18411 0 O75838 CIB2_HUMAN Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2) CIB2 KIP2 Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; cellular response to ATP [GO:0071318]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cytosolic calcium ion concentration [GO:0007204] blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; muscle tendon junction [GO:0005927]; neuromuscular junction [GO:0031594]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; sarcolemma [GO:0042383]; stereocilium [GO:0032420] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] QTIFTEEQLDNYQENPFK 1 13 0.78553 0.027591 0 0 9.52845 0 0 0 0 0 0 0 0 0 O75840 KLF7_HUMAN Krueppel-like factor 7 (Ubiquitous krueppel-like factor) KLF7 UKLF Homo sapiens (Human) axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dendrite morphogenesis [GO:0048813]; glucose homeostasis [GO:0042593]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" FARSDELTRHYR;ISETFGEDLDCFLHASPPPCIEESFR 2 12.6 0.71193 0.14778 0 0 0 0 6.84536 0 0 0 0 0 0 0 O75843 AP1G2_HUMAN AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) AP1G2 Homo sapiens (Human) Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; synapse [GO:0045202]; transport vesicle [GO:0030133] clathrin adaptor activity [GO:0035615] EVIQKECAHIRASFR;IRQVVSIYGSCLDVELQQR;LQDLIEEIR;LSTRLCGDNNR;VLAVNILGRFLLNSDRNIR 5 9.3 0.95487 -0.80368 0 11.587 10.6947 0 9.72756 0 0 0 0 0 0 0 O75844 FACE1_HUMAN CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) ZMPSTE24 FACE1 STE24 Homo sapiens (Human) "adult walking behavior [GO:0007628]; bone mineralization [GO:0030282]; CAAX-box protein processing [GO:0071586]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; CAMKK-AMPK signaling cascade [GO:0061762]; cardiac conduction [GO:0061337]; cardiac muscle cell development [GO:0055013]; cardiac ventricle development [GO:0003231]; cellular response to gamma radiation [GO:0071480]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; growth plate cartilage development [GO:0003417]; hair follicle development [GO:0001942]; heart morphogenesis [GO:0003007]; inflammatory cell apoptotic process [GO:0006925]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; maintenance of rDNA [GO:0043007]; multicellular organism growth [GO:0035264]; negative regulation of miRNA processing [GO:1903799]; neuromuscular process [GO:0050905]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; prenylated protein catabolic process [GO:0030327]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of bone mineralization [GO:0030500]; regulation of cell shape [GO:0008360]; regulation of cellular senescence [GO:2000772]; regulation of defense response to virus [GO:0050688]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of fibroblast proliferation [GO:0048145]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of lipid metabolic process [GO:0019216]; regulation of mitotic cell cycle DNA replication [GO:1903463]; regulation of multicellular organism growth [GO:0040014]; regulation of stress-activated protein kinase signaling cascade [GO:0070302]; regulation of termination of RNA polymerase I transcription [GO:2000730]; regulation of TOR signaling [GO:0032006]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to DNA damage checkpoint signaling [GO:0072423]; thymus development [GO:0048538]; ventricular cardiac muscle tissue development [GO:0003229]" early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; protein-containing complex [GO:0032991] double-stranded DNA binding [GO:0003690]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloexopeptidase activity [GO:0008235] FEFQADAFAKKLGK;NEEEGNSEEIK 2 5.3 0.74547 0.1002 0 0 0 7.04505 0 0 0 0 0 0 8.8923 0 O75845 SC5D_HUMAN Lathosterol oxidase (EC 1.14.19.20) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Delta(7)-sterol C5(6)-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase) SC5D SC5DL Homo sapiens (Human) cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; negative regulation of ferroptosis [GO:0110076] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] C-5 sterol desaturase activity [GO:0000248]; delta7-sterol 5(6)-desaturase activity [GO:0050046]; iron ion binding [GO:0005506] REIKFTVQALPWISILTVALFLLEIR 1 8.7 0.68192 0.16504 0 0 0 0 0 0 0 0 0 0 7.36448 0 O75864 PPR37_HUMAN Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) PPP1R37 KIAA1986 LRRC68 Homo sapiens (Human) protein phosphatase inhibitor activity [GO:0004864] LDLRENEIK;LDYKTCEALEEVFK;VESPPER 3 4.3 0.98037 -2.0067 0 0 0 0 0 0 8.48341 0 8.8029 0 0 0 O75871 CEAM4_HUMAN Cell adhesion molecule CEACAM4 (Carcinoembryonic antigen CGM7) (Carcinoembryonic antigen-related cell adhesion molecule 4) (CEA cell adhesion molecule 4) (Non-specific cross-reacting antigen W236) CEACAM4 CGM7 Homo sapiens (Human) phagocytosis [GO:0006909]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] EQPPPASTPGHGPSHR 1 6.6 0.78501 0.029414 0 0 0 0 0 0 0 0 0 10.8675 0 0 O75874 IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 PICD Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803] ATDFVVPGPGK;GQETSTNPIASIFAWTR;SPNGTIR;SQFEAQK;TVEAEAAHGTVTR;VEITYTPSDGTQK 6 16.4 0 2.1094 12.7657 12.3558 12.3898 0 0 9.17355 8.46324 0 11.6846 12.2848 11.1738 0 O75879 GATB_HUMAN "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog)" GATB PET112 PET112L HSPC199 Homo sapiens (Human) glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] AIDYEIQR;QVFEELWK;VDANISVHHPGEPLGVR 3 5.9 0.95204 -0.67956 11.4997 0 0 0 0 9.8724 0 0 0 0 0 8.13576 O75881 CP7B1_HUMAN Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase) CYP7B1 Homo sapiens (Human) B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of epithelial cell proliferation [GO:0050679]; prostate gland epithelium morphogenesis [GO:0060740]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; 25-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396] LGLPGLALAAALLLLALCLLVRRTR;LSSYSTTIR 2 6.7 0.89567 -0.22866 0 0 0 0 0 5.81155 10.4312 0 0 0 0 0 O75882 ATRN_HUMAN Attractin (DPPT-L) (Mahogany homolog) ATRN KIAA0548 MGCA Homo sapiens (Human) cerebellum development [GO:0021549]; inflammatory response [GO:0006954]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] ENYDNAKLFCR;NHSCSEGQISIFRYENCPKDNPMYYCNK;TACGDCTSGSSECMWCSNMK;TNIKEYK 4 4.6 0.97573 -1.4594 0 5.76508 0 0 7.69579 0 0 0 0 0 4.50093 0 O75884 RBBP9_HUMAN Serine hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9) RBBP9 BOG RBBP10 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; response to nematode [GO:0009624]; type II pneumocyte differentiation [GO:0060510] nucleoplasm [GO:0005654] hydrolase activity [GO:0016787] ASGYFTRPWQWEK 1 7 0.80825 0.011404 0 0 0 0 0 0 0 3.82059 0 0 0 0 O75886 STAM2_HUMAN Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) STAM2 HBP Homo sapiens (Human) macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] LVNEAPVYSVYSK 1 2.5 0.42802 0.19639 0 0 0 0 0 0 0 0 0 0 0 11.106 O75899 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]" cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888] GLLMLFGCFLAWETR;IILGQFDQNMAAK;LLLLLLLPLLLPLAPGAWGWAR;TNPDAATQNRR 4 6.5 0.3905 0.21363 0 6.83378 9.70879 0 0 0 5.79275 0 0 0 0 7.79279 O75901 RASF9_HUMAN Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor) RASSF9 PAMCI PCIP1 Homo sapiens (Human) endosomal transport [GO:0016197]; intracellular transport [GO:0046907]; protein targeting [GO:0006605]; signal transduction [GO:0007165] cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510] FLLGKPSDYCIIEKWRGSER;SMKAGLK;VLPPLTRILKLWK 3 9.2 0.88207 -0.1615 0 0 0 10.9354 0 10.3274 0 11.6373 6.40417 0 11.0927 0 O75907 DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) DGAT1 AGRP1 DGAT Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol O-acyltransferase activity [GO:0004144]; identical protein binding [GO:0042802]; retinol O-fatty-acyltransferase activity [GO:0050252] DLYYFLFAPTLCYELNFPR 1 3.9 0.78384 0.023901 0 0 0 0 0 0 8.58327 0 0 0 0 0 O75908 SOAT2_HUMAN Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) SOAT2 ACACT2 ACAT2 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; intestinal cholesterol absorption [GO:0030299]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; very-low-density lipoprotein particle assembly [GO:0034379] brush border [GO:0005903]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] acyltransferase activity [GO:0016746]; cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; sterol O-acyltransferase activity [GO:0004772] LQRTEGLGGERER 1 2.5 0.86555 -0.087471 0 0 0 0 0 0 0 0 0 0 9.46465 0 O75909 CCNK_HUMAN Cyclin-K CCNK CPR4 Homo sapiens (Human) "cell division [GO:0051301]; DNA damage response [GO:0006974]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of signal transduction [GO:0009966]; transcription by RNA polymerase II [GO:0006366]" cyclin K-CDK12 complex [GO:0002944]; cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase binding [GO:0019901]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] VEETPKK 1 1.2 0.49011 0.18954 0 0 9.28056 0 0 0 0 0 0 0 0 0 O75911 DHRS3_HUMAN Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1) DHRS3 RDH17 SDR16C1 UNQ2424/PRO4983 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cardiac septum morphogenesis [GO:0060411]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; outflow tract morphogenesis [GO:0003151]; regulation of ossification [GO:0030278]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; roof of mouth development [GO:0060021]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; photoreceptor outer segment membrane [GO:0042622] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; electron transfer activity [GO:0009055]; nucleotide binding [GO:0000166] GIGRQLAREFAER 1 4.3 0.86521 -0.087429 0 0 0 0 0 0 10.6108 0 0 0 0 0 O75912 DGKI_HUMAN Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107) DGKI Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] ALSAQRLSPRWCFLDDR;LAPAMIR;VIGHEDLETAV 3 3.3 0.96334 -1.0895 10.6391 9.39968 0 0 0 0 0 0 0 0 0 10.3488 O75914 PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) PAK3 OPHN3 Homo sapiens (Human) axonogenesis [GO:0007409]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; dendrite development [GO:0016358]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; regulation of postsynapse organization [GO:0099175]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; synapse organization [GO:0050808] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] ELLQHPFLKLAKPLSSLTPLIIAAK;EVTPPSAENANSSTLYR;LAKPLSSLTPLIIAAKEAIK;LLQTSNITK;MGIPEQWARLLQTSNITKLEQK;SIFPGGGDK 6 13.6 0.9303 -0.46907 0 0 0 0 8.1497 7.86641 7.55505 10.2533 0 3.22214 7.49889 10.525 O75916 RGS9_HUMAN Regulator of G-protein signaling 9 (RGS9) RGS9 Homo sapiens (Human) dark adaptation [GO:1990603]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; light adaption [GO:0036367]; negative regulation of signal transduction [GO:0009968]; nervous system development [GO:0007399]; regulation of calcium ion export across plasma membrane [GO:1905912]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to estradiol [GO:0032355]; visual perception [GO:0007601] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] EVICPWESL 1 1.3 0.93616 -0.53406 0 0 0 0 11.4699 0 0 0 0 0 0 0 O75923 DYSF_HUMAN Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) DYSF FER1L1 Homo sapiens (Human) macrophage activation involved in immune response [GO:0002281]; monocyte activation involved in immune response [GO:0002280]; negative regulation of phagocytosis [GO:0050765]; regulation of neurotransmitter secretion [GO:0046928] centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipid binding [GO:0005543] DLAAMDK;EELYCPPITVKVIDNR;LVEHSEQK;MLCCLLVR;NLVDPFVEVSFAGK 5 2.5 0.98044 -1.6774 0 0 12.0065 0 0 0 0 0 9.8575 10.6829 0 0 O75935 DCTN3_HUMAN Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) DCTN3 DCTN22 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819] structural molecule activity [GO:0005198] IEDLIKYLDPEYIDR;VEELERWVYGPGGAR 2 16.1 0.9456 -0.64305 0 0 0 0 0 0 0 0 0 8.42442 0 10.9833 O75936 BODG_HUMAN "Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" BBOX1 BBH BBOX Homo sapiens (Human) carnitine biosynthetic process [GO:0045329] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] gamma-butyrobetaine dioxygenase activity [GO:0008336]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; zinc ion binding [GO:0008270] IIELDDK;VGIVRLTGASDKPGEVSK 2 6.5 0.94371 -0.62708 0 4.52669 0 0 0 0 0 9.77437 0 0 0 0 O75937 DNJC8_HUMAN DnaJ homolog subfamily C member 8 (Splicing protein spf31) DNAJC8 SPF31 HSPC315 HSPC331 Homo sapiens (Human) cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544] AFEAVDK;QTMKLFAELEIK 2 7.5 0.9548 -0.88394 0 0 0 0 9.00169 0 0 0 0 9.28974 0 0 O75947 ATP5H_HUMAN "ATP synthase subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d)" ATP5PD ATP5H My032 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] AGLVDDFEK 1 5.6 0.91017 -0.29486 0 0 0 0 0 0 0 0 0 10.2287 0 10.4503 O75952 CABYR_HUMAN Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86) CABYR CBP86 FSP2 Homo sapiens (Human) epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; sperm capacitation [GO:0048240] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; SH3 domain binding [GO:0017124] LECLKEPGK;TSVESKVPTQMEK 2 4.5 0.9729 -2.7714 0 0 0 9.91582 0 0 0 0 0 0 0 0 O75953 DNJB5_HUMAN DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) DNAJB5 HSC40 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; response to unfolded protein [GO:0006986] cytosol [GO:0005829] protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] AWTLNGFVKFR;EPNAEEK;RAPEPLYPRR;VQDPPVVHELR 4 8.4 0.97656 -1.4901 8.91031 13.0837 0 0 0 0 9.77584 0 10.9016 0 0 0 O75955 FLOT1_HUMAN Flotillin-1 FLOT1 Homo sapiens (Human) "axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; intracellular signal transduction [GO:0035556]; plasma membrane raft assembly [GO:0044854]; plasma membrane raft organization [GO:0044857]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931] ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020] DIHDDQDYLHSLGK 1 3.3 0.7839 0.023586 0 0 0 0 6.07281 0 0 6.8125 0 0 0 0 O75962 TRIO_HUMAN Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) TRIO Homo sapiens (Human) axon guidance [GO:0007411]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; negative regulation of fat cell differentiation [GO:0045599]; neuron projection morphogenesis [GO:0048812]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of small GTPase mediated signal transduction [GO:0051056] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASLDTSELER;AVEVMCIVPR;CRVCGRPKASITWK;ERHLFLFEMSLVFSKEVK;EVKDSSGR;GALKEPIHIPK;GFTVIVDMR;HLEQKEAFLKACTLAR;LDQCQQYVVFERSAK;SIKNFLQSRLLPR;VLHYWTMRK;VQDLLEFLHEK;VSTMLDR 13 4.8 0.97445 -3.5292 8.26637 7.62899 8.66017 8.95835 0 10.5646 11.5744 12.2499 6.11871 8.3821 5.90949 0 O75964 ATP5L_HUMAN "ATP synthase subunit g, mitochondrial (ATPase subunit g) (ATP synthase membrane subunit g)" ATP5MG ATP5L Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] GIIGYDV;TPALVNAAVTYSKPR;VELVPPTPAEIPR 3 34 0 3.3696 0 0 0 0 0 0 0 0 0 9.35652 9.4641 0 O75969 AKAP3_HUMAN A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) AKAP3 AKAP110 SOB1 Homo sapiens (Human) acrosome reaction [GO:0007340]; blastocyst hatching [GO:0001835]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; single fertilization [GO:0007338] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] protein kinase A binding [GO:0051018] EKMYSEPKSEEETCAK;ERQGPDDKPPSK;ERQLNEAVGNVTPLQLLDWLMVNL;EVFESRNGDYAREGGR;MSEKVDWLQSQNGVCK;TLKIQVKDTTIATILLK 6 11.8 0.97462 -3.6789 9.772 5.5439 0 9.23501 0 0 0 5.47063 10.957 0 9.30656 0 O75970 MPDZ_HUMAN Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) tight junction assembly [GO:0120192] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ATGVIVKTILPGGVADQHGR;GSLPQLVSPIVSR;NALASEIQGLR;SLTEHGVAATDGR;TVFAKGAASEDGRLK;VELWREPSK 6 3.9 0.97503 -3.159 0 0 12.251 0 0 0 0 0 0 12.1015 11.5419 0 O75971 SNPC5_HUMAN snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) SNAPC5 SNAP19 Homo sapiens (Human) snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription initiation at RNA polymerase III promoter [GO:0006384] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995] SHVTEEEEEEEEEESDS 1 17.3 0.68172 0.16527 0 3.23268 4.78539 0 0 0 0 0 0 0 0 0 O75976 CBPD_HUMAN Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) CPD Homo sapiens (Human) peptide metabolic process [GO:0006518]; protein processing [GO:0016485] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270] DCTSKIGQTNAR;EFETLIK;MMSTGSK 3 1.9 0.96177 -1.0707 11.1241 8.20716 0 0 5.34305 0 0 0 0 0 8.43371 0 O76001 OR2J3_HUMAN Olfactory receptor 2J3 (Hs6M1-3) (Olfactory receptor OR6-16) (OR6-6) (Olfactory receptor 6-6) OR2J3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVLRMQSTTGLQK 1 4.2 0.94104 -0.60828 0 0 0 0 0 0 0 0 0 0 0 10.4995 O76013 KRT36_HUMAN "Keratin, type I cuticular Ha6 (Hair keratin, type I Ha6) (Keratin-36) (K36)" KRT36 HHA6 HKA6 KRTHA6 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of keratinocyte differentiation [GO:0045616] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] LAADDFR;LEGEIATYR;TITEEIRDGK 3 5.6 0.94598 -0.65244 0 0 0 0 0 0 0 0 11.0758 0 9.39913 0 O76021 RL1D1_HUMAN Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) RSL1D1 CATX11 CSIG PBK1 L12 Homo sapiens (Human) osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880] chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730] cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] ALPASETPK;ATNESEDEIPQLVPIGK;AVDALLTHCK;AVDALLTHCKSRK;ELRVRLTLPHSIR;MEDSASASLSSAAATGTSTSTPAAPTAR;QLDKEQVR;SPNPSTPR;TEQFYRKLLNK;TPANEKVEIQK;TVSQIISLQTLKKEYK 11 27.3 0 41.484 8.5889 7.10873 8.9843 9.26477 9.2723 8.82289 0 9.27172 0 11.0038 12.5125 0 O76024 WFS1_HUMAN Wolframin WFS1 Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; glucose homeostasis [GO:0042593]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nervous system process [GO:0050877]; olfactory behavior [GO:0042048]; pancreas development [GO:0031016]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672] ATPase binding [GO:0051117]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; DNA-binding transcription factor binding [GO:0140297]; proteasome binding [GO:0070628]; ubiquitin protein ligase binding [GO:0031625] LKLLAKHPCHIK;SLTRSSMVK;TQILCSHLEGHR 3 3.7 0.98084 -1.5941 0 0 0 0 0 9.63245 0 8.11925 0 0 13.8318 0 O76027 ANXA9_HUMAN Annexin A9 (Annexin XXXI) (Annexin-31) (Annexin-9) (Pemphaxin) ANXA9 ANX31 Homo sapiens (Human) cell-cell adhesion [GO:0098609] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle membrane [GO:0012506] acetylcholine receptor activity [GO:0015464]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543] SAIVDVLTNR 1 2.9 0.93635 -0.55224 0 0 0 0 0 0 0 0 0 7.4564 0 0 O76031 CLPX_HUMAN "ATP-dependent clpX-like chaperone, mitochondrial (EC 3.6.4.10) (ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial) (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)" CLPX Homo sapiens (Human) ATP metabolic process [GO:0046034]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] cytosol [GO:0005829]; endopeptidase Clp complex [GO:0009368]; mitochondrial endopeptidase Clp complex [GO:0009841]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; peptidase activator activity [GO:0016504]; protein dimerization activity [GO:0046983]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GGNQLRCPK;LGTFETQILQR 2 3.2 0.97961 -1.5651 0 0 0 2.29869 2.32092 0 0 4.35417 0 0 0 7.88026 O76036 NCTR1_HUMAN Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335) NCR1 LY94 Homo sapiens (Human) cellular defense response [GO:0006968]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell activation [GO:0030101]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; signal transduction [GO:0007165] plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514] DHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSR;ISAQQQTLPKPFIWAEPHFMVPK;VTFYCRLDTATSMFLLLK 3 25.3 0.71565 0.14219 8.17013 9.73079 10.4609 0 0 0 0 0 0 0 0 0 O76038 SEGN_HUMAN Secretagogin SCGN SECRET Homo sapiens (Human) regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; nucleus [GO:0005634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transport vesicle membrane [GO:0030658] calcium ion binding [GO:0005509] DLFLHHK;MDACSTEER;QQFMTTQDASKDGRIR 3 11.6 0.93817 -0.57384 0 0 0 0 0 9.37808 9.5919 0 0 0 0 0 O76039 CDKL5_HUMAN Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) CDKL5 STK9 Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cilium assembly [GO:1902017]; regulation of dendrite development [GO:0050773]; regulation of postsynapse organization [GO:0099175] "centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; dendrite cytoplasm [GO:0032839]; dendritic growth cone [GO:0044294]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]" ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] ETTLRELKMLR;FPAVNHPQSLER;LDPADRYLTEQCLNHPTFQTQR;SVSNLSEARAQIAEPSTSR 4 6.7 0.97781 -1.5131 5.04976 0 0 0 0 0 0 0 0 6.95257 9.76285 0 O76041 NEBL_HUMAN Nebulette (Actin-binding Z-disk protein) NEBL C10orf113 LNEBL Homo sapiens (Human) cardiac muscle thin filament assembly [GO:0071691] extracellular exosome [GO:0070062]; I band [GO:0031674]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; filamin binding [GO:0031005]; structural constituent of muscle [GO:0008307]; tropomyosin binding [GO:0005523] GNAVLQSQVK;RTSEIYSQR;RVKENQK;TTQQNISAVFYK;VYKEDFEK 5 4.5 0.97433 -3.0533 12.5187 0 0 9.256 0 0 0 0 0 0 0 10.8033 O76050 NEUL1_HUMAN E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1) NEURL1 NEURL NEURL1A RNF67 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of synapse maturation [GO:0090129]; protein monoubiquitination [GO:0006513]; regulation of postsynapse assembly [GO:0150052]; skeletal muscle tissue development [GO:0007519]; sperm axoneme assembly [GO:0007288] apical dendrite [GO:0097440]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] "metal ion binding [GO:0046872]; translation factor activity, non-nucleic acid binding [GO:0045183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]" ITKKQCCWSGALR 1 2.3 0.86511 -0.087175 0 0 0 0 0 0 0 0 9.3617 0 0 0 O76054 S14L2_HUMAN SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) SEC14L2 C22orf6 KIAA1186 KIAA1658 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of cholesterol biosynthetic process [GO:0045540] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phospholipid binding [GO:0005543]; vitamin E binding [GO:0008431] MSGRVGDLSPRQK 1 3.2 0.86728 -0.092969 0 4.31056 3.74717 0 0 0 0 0 0 0 0 0 O76061 STC2_HUMAN Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) STC2 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endoplasmic reticulum unfolded protein response [GO:0030968]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; regulation of hormone biosynthetic process [GO:0046885]; regulation of store-operated calcium entry [GO:2001256]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] enzyme binding [GO:0019899]; heme binding [GO:0020037]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803] AHALRHRFGCISR 1 4.3 0.86901 -0.093965 0 0 0 0 6.80916 0 0 0 0 0 0 0 O76062 ERG24_HUMAN Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (Another new gene 1 protein) (C-14 sterol reductase) (C14SR) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) TM7SF2 ANG1 Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] delta14-sterol reductase activity [GO:0050613]; NADP binding [GO:0050661] LLVSGWWGMVR 1 2.6 0.89772 -0.23329 0 0 0 9.96967 0 0 0 0 0 0 0 0 O76064 RNF8_HUMAN E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8) RNF8 KIAA0646 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; signal transduction in response to DNA damage [GO:0042770]; sperm DNA condensation [GO:0035092]; ubiquitin-dependent protein catabolic process [GO:0006511] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]" chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] IECPICRK;IECPICRKDIK;QTQKGNSK;SLNGVWLNRAR 4 6.2 0.96368 -1.1888 0 10.1635 0 0 0 0 0 9.12047 9.81466 4.90453 0 0 O76074 PDE5A_HUMAN "cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)" PDE5A PDE5 Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of T cell proliferation [GO:0042130]; oocyte development [GO:0048599]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of oocyte development [GO:0060282]; regulation of nitric oxide mediated signal transduction [GO:0010749]; relaxation of cardiac muscle [GO:0055119]; T cell proliferation [GO:0042098] cytosol [GO:0005829] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" KATREMVNAWFAER;KELNIEPTDLMNREK;TTLKIIK 3 4.1 0.96576 -1.2592 0 10.2192 4.51986 0 0 9.38707 0 0 0 0 0 0 O76075 DFFB_HUMAN DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) DFFB CAD DFF2 DFF40 Homo sapiens (Human) apoptotic chromosome condensation [GO:0030263]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; negative regulation of apoptotic DNA fragmentation [GO:1902511] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] KFGVAGR;LVHIVCHK;LVHIVCHKK;SCQEVLRKGCLR 4 8.3 0.94152 -0.60226 0 0 0 7.64306 0 0 0 3.23508 8.27188 0 0 0 O76080 ZFAN5_HUMAN AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) ZFAND5 ZA20D2 ZNF216 Homo sapiens (Human) face development [GO:0060324]; fibroblast migration [GO:0010761]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculature development [GO:0001944] cytoplasm [GO:0005737] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQR;MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYK 2 18.8 0.96814 -1.3257 0 8.26256 0 0 0 0 0 6.70321 0 0 0 0 O76083 PDE9A_HUMAN "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" PDE9A Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; cGMP metabolic process [GO:0046068]; negative regulation of neural precursor cell proliferation [GO:2000178]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of long-term synaptic potentiation [GO:1900273]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" DVPTYPK;HAEIMDSFKEK;SSRTNCPCK;TPYKVRPVAIKQLSER 4 8.7 0.97473 -3.2384 0 0 0 0 0 0 0 0 0 0 0 11.3948 O76094 SRP72_HUMAN Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) SRP72 Homo sapiens (Human) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; TPR domain binding [GO:0030911] NSQDDYDEER 1 1.5 0.94162 -0.603 0 0 0 0 0 0 0 0 0 0 9.31538 0 O76095 JTB_HUMAN Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein) JTB HSPC222 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; positive regulation of protein kinase activity [GO:0045860]; regulation of cell population proliferation [GO:0042127] centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; spindle [GO:0005819] protein kinase binding [GO:0019901] HLCWLLCAFTLK 1 8.2 0.88372 -0.17208 0 0 0 9.75159 0 0 0 0 0 0 0 0 O94759 TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to temperature stimulus [GO:0071502]; dendritic cell chemotaxis [GO:0002407]; dendritic cell differentiation [GO:0097028]; protein homotetramerization [GO:0051289]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]; release of sequestered calcium ion into cytosol [GO:0051209]; response to heat [GO:0009408]; response to hydroperoxide [GO:0033194]; response to purine-containing compound [GO:0014074]; temperature homeostasis [GO:0001659]; zinc ion transmembrane transport [GO:0071577] cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; ficolin-1-rich granule membrane [GO:0101003]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; intracellularly gated calcium channel activity [GO:0015278]; ligand-gated calcium channel activity [GO:0099604]; manganese ion transmembrane transporter activity [GO:0005384]; mono-ADP-D-ribose binding [GO:0072571]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272] AIGVFTECYRK;EEEDTDSSEEMLALAEEYEHR;FQRHDLIEEYHGRPAAPPPFILLSHLQLFIK;LLLPVPHVKLNVQGVSLR;LLLPVPHVKLNVQGVSLRSLYK;QESLSSWIPENIK;VPWETEFLIYDPPFYTAERK 7 7.9 0.8729 -0.10436 0 9.88699 0 0 5.8125 10.283 0 5.9813 0 0 0 0 O94760 DDAH1_HUMAN "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073] cytosol [GO:0005829]; extracellular exosome [GO:0070062] amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; metal ion binding [GO:0046872] SAKGEEVDVAR 1 3.9 0.97618 -1.4837 0 11.6578 0 0 0 0 0 0 0 0 0 0 O94761 RECQ4_HUMAN "ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)" RECQL4 RECQ4 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820] "chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821] FQNLDSIIIYCNRR;ILSGISTLLVLPTGAGK;SRQGSVPDYGQR 3 3.6 0.97883 -1.917 0 0 0 8.13715 0 0 10.9456 0 0 0 7.51436 0 O94762 RECQ5_HUMAN "ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)" RECQL5 RECQ5 Homo sapiens (Human) cell division [GO:0051301]; cellular response to camptothecin [GO:0072757]; cellular response to xenobiotic stimulus [GO:0071466]; chromosome separation [GO:0051304]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle [GO:0000278]; mitotic DNA-templated DNA replication [GO:1990506]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; transcription preinitiation complex [GO:0097550] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; RNA polymerase II complex binding [GO:0000993]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ANLFYDVQFK;EEAQNLIR;EVAKLQEKR;KAKSSSGGSSLAK;LLEEALSSNR;SVKEEAQNLIR;VSSLNSKLSAQER 7 6.7 0.97466 -3.926 0 0 0 6.87553 12.0363 0 0 10.2874 12.6737 13.0412 0 0 O94763 RMP_HUMAN Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) URI1 C19orf2 NNX3 PPP1R19 RMP URI Homo sapiens (Human) cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714] ENSVCSDTSESSAAEFDDRR 1 3.7 0.57891 0.18087 0 0 0 0 0 0 0 0 0 4.3726 0 0 O94769 ECM2_HUMAN Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2) ECM2 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] collagen V binding [GO:0070052]; heparin binding [GO:0008201]; integrin binding [GO:0005178] KQRPGEERR;NEFSGDSSEQR 2 2.9 0.9411 -0.5984 0 0 0 0 0 0 0 0 0 0 8.84336 10.931 O94779 CNTN5_HUMAN Contactin-5 (Neural recognition molecule NB-2) (hNB-2) CNTN5 Homo sapiens (Human) axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; presynapse assembly [GO:0099054]; sensory perception of sound [GO:0007605] axon [GO:0030424]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552] cell-cell adhesion mediator activity [GO:0098632] ENKRIAILPDGSLR;RIAILPDGSLRILNASK;TNEAVPK;VLSPPTPLTLR;YVCRGENVFGSAEIIASLSVK 5 5.4 0.97164 -1.3516 0 11.204 0 8.28253 0 0 6.76832 0 0 0 6.45348 0 O94782 UBP1_HUMAN "Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]" USP1 Homo sapiens (Human) DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of error-prone translesion synthesis [GO:1904333]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of DNA repair [GO:0006282]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; skeletal system development [GO:0001501] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233] HLFNIISR;ISYVVQSLK;KATSDTLESPPK;LPKGNGK;PGVIPSESNGLSRGSPSKK;VASTAFAENR 6 8.3 0.97635 -4.6845 0 0 0 9.64232 0 0 0 10.4853 8.5267 10.4839 0 11.4653 O94788 AL1A2_HUMAN Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) ALDH1A2 RALDH2 Homo sapiens (Human) 9-cis-retinoic acid biosynthetic process [GO:0042904]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; face development [GO:0060324]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]; vitamin A metabolic process [GO:0006776] cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase activity [GO:0001758] EEIFGPVQEILR;KQYNKILELIQSGVAEGAK;NQCETVWLK;VTLELGGK;VVGSPFDPTTEQGPQIDK 5 13.3 0.97783 -1.9511 10.721 0 0 9.34543 0 9.90185 0 0 0 0 0 0 O94804 STK10_HUMAN Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) STK10 LOK Homo sapiens (Human) intracellular signal transduction [GO:0035556]; lymphocyte aggregation [GO:0071593]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of lymphocyte migration [GO:2000401] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LTTDNRR;REICDKER;VLLKIAKSDPPTLLTPSK 3 3.3 0.96318 -1.0905 0 0 0 0 0 0 9.24277 9.58446 0 0 0 0 O94806 KPCD3_HUMAN Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) PRKD3 EPK2 PRKCN Homo sapiens (Human) intracellular signal transduction [GO:0035556]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; protein phosphorylation [GO:0006468]; sphingolipid biosynthetic process [GO:0030148] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" IGERYITHESDDAR;MVMCRVK;QGLKCEGCGLNYHKR;VFVVMEK;VPHTFAVHSYTRPTICQYCK 5 7.1 0.97265 -2.6697 0 12.1047 8.47691 0 0 0 0 8.34176 11.9741 0 6.21812 0 O94808 GFPT2_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) GFPT2 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] GSPLLIGVR;LSIHRVK;VKALDEELYK 3 3.8 0.98091 -1.7841 0 0 0 0 0 0 0 9.29588 0 0 0 0 O94811 TPPP_HUMAN Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) TPPP TPPP1 Homo sapiens (Human) astral microtubule organization [GO:0030953]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule nucleation by microtubule organizing center [GO:0051418]; microtubule polymerization [GO:0046785]; myelin assembly [GO:0032288]; negative regulation of tubulin deacetylation [GO:1904428]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of myelination [GO:0031643]; positive regulation of protein polymerization [GO:0032273]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of microtubule cytoskeleton organization [GO:0070507] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic Golgi apparatus [GO:0150051] GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; microtubule nucleator activity [GO:0140490]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; tubulin binding [GO:0015631] TITFEQFQEALEELAK 1 7.3 0.89781 -0.25275 0 0 0 0 0 0 0 0 0 0 0 10.5906 O94812 BAIP3_HUMAN BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3) BAIAP3 KIAA0734 Homo sapiens (Human) "dense core granule maturation [GO:1990502]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of behavior [GO:0050795]; regulation of dense core granule exocytosis [GO:1905413]; regulation of synaptic transmission, GABAergic [GO:0032228]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; secretory vesicle [GO:0099503]; trans-Golgi network membrane [GO:0032588] calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] WFKLEPRSSASR 1 1 0.86862 -0.093878 3.70907 0 0 0 0 0 0 0 0 0 0 0 O94813 SLIT2_HUMAN Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; pulmonary valve morphogenesis [GO:0003184]; response to cortisol [GO:0051414]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; GTPase inhibitor activity [GO:0005095]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; laminin-1 binding [GO:0043237]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; Roundabout binding [GO:0048495] CDCTPGYVGEHCDIDFDDCQDNK;ESYLQIPSAK;GGCAGGQCCGPLR;LSGDCFADLACPEKCR;SLNSLVLYGNK;VIPPGAFSPYK 6 5.5 0.93868 -0.57228 4.73742 0 0 0 0 8.99141 7.08683 11.1877 9.19417 0 0 4.91092 O94818 NOL4_HUMAN Nucleolar protein 4 (Nucleolar-localized protein) NOL4 NOLP HRIHFB2255 Homo sapiens (Human) nucleolus [GO:0005730] RNA binding [GO:0003723] GDEDEDDHEDHDDSEK;IDDHNSNGK;IQAIIDSCR;TTDGVGVDEK;TYGDSGK 5 8 0.96355 -1.0964 0 0 0 0 0 0 0 0 4.91533 0 11.0576 5.94547 O94819 KBTBB_HUMAN Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) KBTBD11 CMLAP KIAA0711 KLHDC7C Homo sapiens (Human) DVLRVQGVSLTALR 1 2.2 0.92244 -0.4424 0 0 0 0 0 0 0 0 0 3.46571 0 0 O94822 LTN1_HUMAN E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) LTN1 C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 HSPC087 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112] ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ALYSMYLRKTK;CCDNDMER;DLPAMVR;GVLPYWPRIFCK;KEFSAQCIPALLGWTK;LSEICVAK;VRFADEILESNK 7 4.2 0.97614 -2.3429 0 0 6.49341 0 0 10.9043 10.0642 0 0 0 5.38419 9.57839 O94823 AT10B_HUMAN Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) ATP10B ATPVB KIAA0715 Homo sapiens (Human) lysosomal membrane organization [GO:0097212]; phospholipid translocation [GO:0045332] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345] GRQSYNLTQQR;IQQLFQKLK;LPQGTCLTFSLLCTLGFDSVR;SQSARVPIQGHYR;TLCIAKKVVSEEDFR 5 4.7 0.97491 -3.2273 0 0 0 10.0478 5.21237 0 0 0 0 9.37484 10.3354 0 O94823 AT10B_HUMAN Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) ATP10B ATPVB KIAA0715 Homo sapiens (Human) lysosomal membrane organization [GO:0097212]; phospholipid translocation [GO:0045332] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345] VINNRECLIYSRK 1 2.6 0.84527 -0.059426 0 0 9.71562 0 0 0 0 0 0 0 0 0 O94826 TOM70_HUMAN Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) TOMM70 KIAA0719 TOM70 TOMM70A Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of apoptotic process [GO:0042981]; response to thyroxine [GO:0097068] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; molecular adaptor activity [GO:0060090]; protein transmembrane transporter activity [GO:0008320] ADEMYDK;EARGRGDASGLK;GLLQLQWK 3 4.4 0.97267 -2.8144 11.7707 0 0 0 0 0 0 0 0 0 0 0 O94827 PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) PLEKHG5 KIAA0720 Homo sapiens (Human) endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] FIHHVNACMRQR;LTKYPLLLKSVLR;LTLAQLYRIR;VQPEPPPGVSAQHR;YCMEEEGCMEYMR 5 6.2 0.95491 -0.9474 0 0 7.75255 6.0029 0 0 0 0 10.3406 4.2561 0 11.8181 O94829 IPO13_HUMAN Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13) IPO13 KIAA0724 RANBP13 Homo sapiens (Human) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] small GTPase binding [GO:0031267] ALHQLYYDPNIENK 1 1.5 0.89724 -0.23417 0 0 0 0 9.00893 0 0 0 0 0 0 0 O94830 DDHD2_HUMAN "Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase)" DDHD2 KIAA0725 SAMWD1 Homo sapiens (Human) lipid droplet organization [GO:0034389]; locomotory behavior [GO:0007626]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; triglyceride catabolic process [GO:0019433]; visual learning [GO:0008542] centriolar satellite [GO:0034451]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] diacylglycerol lipase activity [GO:0120516]; metal ion binding [GO:0046872]; triacylglycerol lipase activity [GO:0004806] EALALCTDR;LQLSEFFDIFEKEK 2 3.2 0.95285 -0.75806 11.2247 0 0 0 0 7.72117 0 0 10.8504 0 0 0 O94832 MYO1D_HUMAN Unconventional myosin-Id MYO1D KIAA0727 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; endocytosis [GO:0006897]; protein transport [GO:0015031] actin cytoskeleton [GO:0015629]; apical dendrite [GO:0097440]; axolemma [GO:0030673]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myelin sheath [GO:0043209]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904] AEVERVKNMLLK;AQMLIRIVLFLQKVWR;GTLARMR;IVLFLQKVWRGTLAR;MDPTKQYK;QTYEKFLHRYK;TNRNDNSSR;VIVQQPGER;VVADAMK 9 7.9 0.9761 -4.6191 11.2865 0 8.25729 0 10.3593 7.71781 0 0 0 3.79587 0 0 O94844 RHBT1_HUMAN Rho-related BTB domain-containing protein 1 RHOBTB1 KIAA0740 Homo sapiens (Human) actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] DVVDEVSVSLR;EDIALNKHR;HLQFWKSHLKK;IYLATSSSK;KVQKPLLQAPFLPPKAPPPVIK;RHLQFWK 6 8.9 0.93026 -0.48757 12.5759 0 7.77933 5.83671 0 10.8485 0 0 0 0 0 8.98345 O94850 DEND_HUMAN Dendrin DDN KIAA0749 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EGEQIWFPKCWIPSPK;TISCHYSRRAPSR 2 4.1 0.97586 -2.2568 0 0 0 0 0 0 0 11.8684 0 0 0 0 O94851 MICA2_HUMAN [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) MICAL2 KIAA0750 MICAL2PV1 MICAL2PV2 MICALCL Homo sapiens (Human) actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfur oxidation [GO:0019417] actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "actin binding [GO:0003779]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" AKSDLQLGGTENFATLPSTRPR;AVHAALQR;DIRDLFGSPK;EGGNQNK;FYELFRGTPLRPVDSWRK;GTLQAFNILTR;ISQKSAENGR;LQQVEEK;LSMVMYLSKFYELFR;SAENGRGGRVLKPVRPLLLPR;VLKPVRPLLLPR 11 6 0.97482 -3.4602 11.2629 0 12.0682 0 0 9.89031 11.6825 5.08313 0 8.94971 3.93216 10.3923 O94854 K0754_HUMAN "Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754)" MACF1 KIAA0754 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] EFANFDFDVWRKK;FQVEQIGENKYR;KLNDALDRLEELK;LANSEPVGTQTAKIQQQIIR;LDPGGLLNSDHR;LNQTSKSTMEK;NIEPTHAPFIEKSR;RGLNKPSK;TLEQARQLATK;TLLPEDSQK;TTTASPRTPGPKR;TWKERLEK;VIEVELAKHHVLK;WIMMEAEGEWEEEKLSDREK 14 5 0.97401 -3.005 2.96373 0 0 0 9.89147 0 0 0 0 0 0 10.9988 O94855 SC24D_HUMAN Protein transport protein Sec24D (SEC24-related protein D) SEC24D KIAA0755 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] LICEELKTMLEK;VGFITYNK;VGFITYNKVLHFFNVK;VLHFFNVK 4 2.7 0.97497 -3.2242 0 0 0 10.3396 4.33049 0 0 0 0 0 0 0 O94856 NFASC_HUMAN Neurofascin NFASC KIAA0756 Homo sapiens (Human) axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422] axon [GO:0030424]; axon initial segment [GO:0043194]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; node of Ranvier [GO:0033268]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] AAPTEVK;LEVKDPTRIYR;LQVSKSPLWPK;LTVSWLKDDEPLYIGNR;MPEDQVAR;MPEDQVARR 6 4.1 0.9737 -2.4658 0 0 0 0 0 7.31786 8.55861 9.03472 11.1645 0 0 0 O94868 FCSD2_HUMAN F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) FCHSD2 KIAA0769 SH3MD3 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833] anchoring junction [GO:0070161]; clathrin-coated pit [GO:0005905]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stereocilium shaft [GO:0120043] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]" EEGEEFEDNMDVFDDSSSSPSGTLR;IDEARENIR;NFISEPAR;SMYPVWK;VGQVGYVPEK 5 8 0.97994 -1.8745 0 8.04827 0 0 0 0 0 0 9.41147 10.554 0 8.12221 O94874 UFL1_HUMAN E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) UFL1 KIAA0776 MAXER NLBP RCAD Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; osteoblast differentiation [GO:0001649]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of reticulophagy [GO:0140501]; protein K69-linked ufmylation [GO:1990592]; protein stabilization [GO:0050821]; protein ufmylation [GO:0071569]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; response to L-glutamate [GO:1902065]; reticulophagy [GO:0061709]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861] protein kinase binding [GO:0019901]; UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568] ARIRGLFSAITRPTAVNSLISK 1 2.8 0.5618 0.18276 0 0 0 0 0 0 0 0 4.69777 0 0 0 O94875 SRBS2_HUMAN Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Z disc [GO:0030018] cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] AKCKASVFEALDSALK;SAPRERR;SIFEYEPGK;VGIFPISYVEKLTPPEK 4 4.5 0.95876 -1.01 0 0 0 0 0 0 0 0 0 0 10.4443 0 O94875 SRBS2_HUMAN Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Z disc [GO:0030018] cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] SAPRERR;SAVAAASQSSDCR;SIFEYEPGK;VGIFPISYVEKLTPPEK 4 5.6 0.86606 -0.089392 0 10.9081 0 8.40816 8.17368 0 0 7.42953 0 0 0 8.29715 O94876 TMCC1_HUMAN Transmembrane and coiled-coil domains protein 1 TMCC1 KIAA0779 Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; membrane fission [GO:0090148] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; rough endoplasmic reticulum [GO:0005791] identical protein binding [GO:0042802] DIQEALEACQTR;GSPQINRK;HLFQHQRRR 3 4.4 0.95559 -0.87594 8.01274 0 7.99678 0 0 0 0 0 0 0 0 0 O94876 TMCC1_HUMAN Transmembrane and coiled-coil domains protein 1 TMCC1 KIAA0779 Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; membrane fission [GO:0090148] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; rough endoplasmic reticulum [GO:0005791] identical protein binding [GO:0042802] DIQEALEACQTR;VQRFSLRR 2 4.2 0.97573 -1.4851 0 0 0 8.57168 13.013 13.0451 0 0 0 8.7881 0 0 O94880 PHF14_HUMAN PHD finger protein 14 PHF14 KIAA0783 Homo sapiens (Human) germinal center B cell differentiation [GO:0002314]; lung alveolus development [GO:0048286]; mesenchymal cell proliferation [GO:0010463]; mesenchymal cell proliferation involved in lung development [GO:0060916]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] histone binding [GO:0042393]; histone reader activity [GO:0140566]; zinc ion binding [GO:0008270] EDENEAER;LENEQEKLHVEYNK;LNIPAILRAPK;QTGYGWICQECDSSSSKEDENEAER;SEGQGIWALLGR;YGAKECSFCEDPR 6 7.9 0.97276 -2.9534 10.4963 0 0 0 0 0 6.66633 8.78395 13.2302 0 0 0 O94885 SASH1_HUMAN SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) SASH1 KIAA0790 PEPE1 Homo sapiens (Human) positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; protein polyubiquitination [GO:0000209]; regulation of epithelial cell migration [GO:0010632]; regulation of protein autoubiquitination [GO:1902498]; regulation of protein K63-linked ubiquitination [GO:1900044] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] G-protein alpha-subunit binding [GO:0001965]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] GVDLETLTENK;YAEDLDQPER 2 1.7 0.91532 -0.37078 0 0 9.79385 0 0 0 0 0 9.91676 0 0 0 O94886 CSCL1_HUMAN CSC1-like protein 1 (Transmembrane protein 63A) TMEM63A KIAA0489 KIAA0792 Homo sapiens (Human) surfactant secretion [GO:0160069] centriolar satellite [GO:0034451]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; nucleic acid binding [GO:0003676]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] LIYLCKEKK;MDSPFLELWQSK;TLFITGLPR 3 3.7 0.95216 -0.72345 0 0 12.4561 8.02392 12.6277 0 0 0 10.2042 10.6475 0 0 O94887 FARP2_HUMAN "FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)" FARP2 KIAA0793 PLEKHC3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; hair cycle process [GO:0022405]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; semaphorin-plexin signaling pathway [GO:0071526] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085] DECKNFWKICVEYHTFFR;EADGIHKDYVFKLQFK;GVAGTSHFR;INTFNWSK;LEMYGIRFHMASDR;LLHYRLLLRR;LQFKSHVYFFR 7 7.8 0.97449 -2.3928 8.69467 9.04253 3.21979 4.0283 5.98495 0 12.8713 0 0 0 0 10.9013 O94888 UBXN7_HUMAN UBX domain-containing protein 7 UBXN7 KIAA0794 UBXD7 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] GSFETAK;NIIREHFIFWQVYHDSEEGQR 2 5.7 0.95166 -0.70335 0 0 0 0 0 0 0 0 0 0 7.34199 6.78346 O94889 KLH18_HUMAN Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) cell division [GO:0051301]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DLVDEAK;ERLHPKNCLGVR;FTNDMMECK;LPLCRPQFLSDRVQQDDLVR 4 9.4 0.96508 -1.1391 0 0 2.94877 0 5.75104 0 0 7.4025 0 8.87403 0 0 O94892 ZN432_HUMAN Zinc finger protein 432 ZNF432 KIAA0798 Homo sapiens (Human) DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "damaged DNA binding [GO:0003684]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" THTGEKPYICSECGKGFTTKHYVIIHQR 1 4.3 0.70943 0.15938 0 0 0 0 0 0 0 0 8.64627 0 0 0 O94898 LRIG2_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) LRIG2 KIAA0806 LIG2 Homo sapiens (Human) innervation [GO:0060384]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; regulation of neuron migration [GO:2001222]; regulation of platelet-derived growth factor receptor signaling pathway [GO:0010640]; sensory perception of sound [GO:0007605] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; growth cone [GO:0030426]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] DSEILYDVDTENFVR;EPDCSASSMSCHR;IPLLDCSRR;LNLGDNR;NRMSMIPPK 5 5 0.97201 -2.7072 0 0 0 0 0 0 6.72096 0 5.3605 0 0 0 O94900 TOX_HUMAN Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX) TOX KIAA0808 Homo sapiens (Human) "CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cerebral cortex neuron differentiation [GO:0021895]; chromatin organization [GO:0006325]; leukocyte differentiation [GO:0002521]; lymph node development [GO:0048535]; natural killer cell differentiation [GO:0001779]; NK T cell lineage commitment [GO:0002364]; Peyer's patch development [GO:0048541]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]" nucleus [GO:0005634] chromatin DNA binding [GO:0031490] SYSEPVDVK 1 1.7 0.90941 -0.31574 0 0 0 0 0 0 0 0 0 0 7.60829 0 O94901 SUN1_HUMAN SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) centrosome localization [GO:0051642]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; spermatogenesis [GO:0007283] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]" cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein-membrane adaptor activity [GO:0043495] DAVGQPPR;FLVLLIPLFLLLAGLSLR;IGAVGQAVSR;LDPVFDSPR;TGCETVDAVQERVDVQVR;VHGEPVK 6 8.9 0.97443 -2.449 9.12696 0 0 9.53078 0 6.58597 0 3.9472 0 0 0 0 O94903 PLPHP_HUMAN Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein) PLPBP PROSC Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] pyridoxal phosphate binding [GO:0030170] GSPERLKVMVQINTSGEESK;IGSTIFGERDYSK;ILSLCPEIK 3 15.3 0.72689 0.12503 9.45444 0 0 11.7171 7.56628 11.6269 0 0 0 13.4997 13.5783 12.6439 O94905 ERLN2_HUMAN Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; ERAD pathway [GO:0036503]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625] MLIAMQQDP 1 4.4 0.90937 -0.316 10.889 0 0 0 0 0 0 0 0 0 0 0 O94906 PRP6_HUMAN Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) PRPF6 C20orf14 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] CPHSTPLWLLLSR;GTEMCPK;LQPGDTAK;LTPVPDSFFAK;NPGLWLESVRLEYR;NPGLWLESVRLEYRAGLK;SRLKNPK 7 6.8 0.96375 -1.2034 0 13.3123 11.3299 0 0 9.7961 14.1551 13.7859 13.9421 0 11.9296 0 O94907 DKK1_HUMAN Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) DKK1 UNQ492/PRO1008 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; endoderm formation [GO:0001706]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; hair follicle development [GO:0001942]; heart induction [GO:0003129]; heart valve development [GO:0003170]; learning or memory [GO:0007611]; limb development [GO:0060173]; mesoderm formation [GO:0001707]; motor learning [GO:0061743]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of neuron projection development [GO:0010977]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of presynapse assembly [GO:1905607]; negative regulation of protein binding [GO:0032091]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of midbrain dopaminergic neuron differentiation [GO:1904958]; positive regulation of Wnt signaling pathway, calcium modulating pathway [GO:0045813]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of endodermal cell fate specification [GO:0042663]; regulation of neuron apoptotic process [GO:0043523]; regulation of receptor internalization [GO:0002090]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to retinoic acid [GO:0032526]; synapse pruning [GO:0098883]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] co-receptor binding [GO:0039706]; growth factor activity [GO:0008083]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] CYCGEGLSCR;RCMRHAMCCPGNYCK 2 9.4 0.53931 0.18521 0 0 0 0 6.38042 0 0 0 0 0 0 7.99836 O94910 AGRL1_HUMAN Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2) ADGRL1 KIAA0821 LEC2 LPHN1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] axon [GO:0030424]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524] ALEEPLLLPR;AVVETVDNLLRPEALESWK;GSSSAAK;IYVMPWIPYR;MWNDTVR;SVYVDDDSEAAGNR 6 4.5 0.97097 -1.3397 0 0 0 0 0 0 0 0 10.6446 0 9.66544 10.6031 O94911 ABCA8_HUMAN ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) ABCA8 KIAA0822 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol transport [GO:0030301]; lipid transport [GO:0006869]; positive regulation of cholesterol efflux [GO:0010875]; regulation of cholesterol efflux [GO:0010874]; sphingomyelin biosynthetic process [GO:0006686]; transmembrane transport [GO:0055085]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] ALMTMMGLR;DYLLEMK;GLRKGDAEVAITR;LLPQEEP;LPVEDVQPLAQAFFK;MDVQPFLVFLIPFLHFIIFLFTLRCLEWK;TLSEGIKRK;VTFTNTYSYHLKFLLGHGMPAKK 8 6.9 0.97494 -3.6169 12.0936 0 13.7382 11.834 0 0 0 8.84546 0 2.71532 0 0 O94913 PCF11_HUMAN Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) PCF11 KIAA0824 Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; termination of RNA polymerase II transcription [GO:0006369]" cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993] FDGLHGQPGPRFER;HRESWSSTKGILSPR;ISQHSHGKDQSHRK;LAGSRNK;LSDMNKR;NLVATFICVFEKVDENTRK 6 4.9 0.97268 -2.7258 12.393 0 11.8913 0 0 10.1862 11.9351 0 8.31682 0 7.56986 12.4548 O94915 FRYL_HUMAN Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) FRYL AF4P12 KIAA0826 Homo sapiens (Human) cell morphogenesis [GO:0000902]; neuron projection development [GO:0031175] cell cortex [GO:0005938]; site of polarized growth [GO:0030427] IIGKYVQSPYWK;IIQFIAQER;LDFAMKEIIFDLLSVGK;RPQLSQRRTR;TFTINPERMNIGLR;TLMEFITSRKR;TNPGAFR;VALESLYRLLWVYVIR;WLDNILDSLDKK 9 3.6 0.97973 -1.858 9.9368 0 0 0 5.48614 0 10.4448 10.5888 8.80368 5.17732 10.2065 8.93787 O94916 NFAT5_HUMAN Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) NFAT5 KIAA0827 TONEBP Homo sapiens (Human) calcineurin-NFAT signaling cascade [GO:0033173]; cellular hyperosmotic response [GO:0071474]; cellular response to cytokine stimulus [GO:0071345]; DNA damage response [GO:0006974]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R-loop processing [GO:0062176]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DCEESNMDIFDADSAK;DRTQQGFPTVK;SLYSRESVYDLLPKELQLPPSR;STRARLVFR;YLTEGSR 5 4.2 0.97289 -2.7683 0 0 6.85848 0 13.2138 0 0 0 0 0 0 0 O94919 ENDD1_HUMAN Endonuclease domain-containing 1 protein (EC 3.1.30.-) ENDOD1 KIAA0830 Homo sapiens (Human) innate immune response [GO:0045087] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] ICQRAEGAER;LLPFNPQLFQNNCGETEQDTEKMKK;LMGFIATPFIKLFQLIYYLVVAILK;VLVDVATFPVYTMGAIPIVCK 4 16.2 0.91505 -0.37962 0 0 5.37177 8.56281 4.2355 0 0 7.90183 0 0 8.63941 0 O94923 GLCE_HUMAN D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) GLCE KIAA0836 Homo sapiens (Human) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]; negative regulation of cell projection organization [GO:0031345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of SMAD protein signal transduction [GO:0060391] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]" AVKPTKIMPKK;TLIIICALFTLVTVLLWNK 2 4.9 0.84718 -0.068283 0 0 0 5.62126 0 0 0 0 0 0 0 0 O94925 GLSK_HUMAN "Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]" GLS GLS1 KIAA0838 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; intracellular glutamate homeostasis [GO:0090461]; protein homotetramerization [GO:0051289]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; suckling behavior [GO:0001967] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] glutaminase activity [GO:0004359] VADYIPQLAK 1 1.5 0.03442 0.54115 0 10.612 0 0 0 0 0 0 0 0 0 0 O94927 HAUS5_HUMAN HAUS augmin-like complex subunit 5 HAUS5 KIAA0841 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] LGLPPGK;QVLTQRLQGLVEEVERR 2 3.8 0.11756 0.36172 0 0 0 0 0 0 0 0 0 10.695 9.79829 0 O94929 ABLM3_HUMAN Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) ABLIM3 KIAA0843 HMFN1661 Homo sapiens (Human) cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] DFITGEVISALGR;LEGNFWK;NQEYICTQDYQQLYGTR;NQEYICTQDYQQLYGTRCDSCR;VICDIYENLDLRQR 5 10.3 0.96516 -1.1382 0 0 0 0 8.8957 0 10.5631 10.7335 0 14.8499 0 0 O94933 SLIK3_HUMAN SLIT and NTRK-like protein 3 SLITRK3 KIAA0848 Homo sapiens (Human) "axonogenesis [GO:0007409]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]" cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634] IESGAFR;ILKRLYLHENK;LYLQRNSMR;NLSKLRVLILNDNLIPMLPTNLFK;SPENLTHR 5 6 0.97319 -2.566 7.52529 0 0 0 0 11.4445 0 0 6.64616 0 0 0 O94941 RNF37_HUMAN RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) UBOX5 KIAA0860 RNF37 UBCE7IP5 UIP5 Homo sapiens (Human) protein polyubiquitination [GO:0000209] focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450] EAFTLVGKVLLK;IDHFLLQHSIPGCHLLGR;LEVWGQPAK;VINLCLPQFRPR;VLLKNQSQVVFSHR 5 11.3 0.97152 -1.3484 0 10.328 11.6883 0 10.0297 0 0 0 11.1549 7.83517 0 10.2593 O94953 KDM4B_HUMAN Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) KDM4B JHDM3B JMJD2B KIAA0876 Homo sapiens (Human) brain development [GO:0007420]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872] ILQPERYELWK;IMTFRPTMEEFK;VATQCTCR;VATQCTCRKDMVK 4 3.3 0.98054 -2.014 0 0 0 0 0 11.5297 0 0 0 9.82744 0 8.43946 O94964 MTCL2_HUMAN "Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]" MTCL2 C20orf117 KIAA0889 SOGA SOGA1 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; insulin receptor signaling pathway [GO:0008286]; negative regulation of gluconeogenesis [GO:0045721]; regulation of autophagy [GO:0010506] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496] AADPWVLK;AADPWVLKHSELEKQDNSWK;ACTGDSWTQNTPNEYIK;CQLHFAK;DLPEWEPRIR;EITNCVRQAMRSGSLER;GLTELQQQFAK;LEEENEELRQRLIETELAK;RARLEEENEELR;SYTAPDK;TVSVGLQTDPPR 11 7.4 0.97524 -3.3814 12.2884 10.1235 9.25087 0 0 6.80297 8.24897 0 9.51574 0 9.55373 0 O94964 MTCL2_HUMAN "Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]" MTCL2 C20orf117 KIAA0889 SOGA SOGA1 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; insulin receptor signaling pathway [GO:0008286]; negative regulation of gluconeogenesis [GO:0045721]; regulation of autophagy [GO:0010506] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496] AADPWVLK;AADPWVLKHSELEKQDNSWK;ACTGDSWTQNTPNEYIK;CQLHFAK;DLPEWEPRIR;GLTELQQQFAK;LEEENEELRQRLIETELAK;QKLPFLLILAPPQPPPIL;RARLEEENEELR 9 10.3 0.92139 -0.44138 0 0 0 0 0 0 0 0 0 4.48304 0 0 O94966 UBP19_HUMAN Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) USP19 KIAA0891 ZMYND9 Homo sapiens (Human) ERAD pathway [GO:0036503]; negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] cysteine-type deubiquitinase activity [GO:0004843]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872] CAACQRK;GAVGGAK;MSGGASATGPR;QLLLWRLPNVLIVQLKR 4 3.3 0.96604 -1.1299 0 0 0 0 0 0 0 5.98315 0 11.5999 10.0342 0 O94967 WDR47_HUMAN WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) WDR47 KIAA0893 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuronal stem cell population maintenance [GO:0097150] cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025] LSEAGFK;LSPYPSSPMR;MLNIHVDKLLKPTK 3 3.4 0.95473 -0.94772 0 10.7831 0 0 0 11.3732 0 0 0 0 3.68784 0 O94972 TRI37_HUMAN E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) TRIM37 KIAA0898 MUL POB1 Homo sapiens (Human) "aggresome assembly [GO:0070842]; negative regulation of centriole replication [GO:0046600]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein import into peroxisome matrix [GO:0016558]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]" aggresome [GO:0016235]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] NIIREFASDFEVGECWGYNR 1 2.1 0.91602 -0.43076 0 8.69655 0 0 0 0 0 0 0 0 0 0 O94973 AP2A2_HUMAN AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) AP2A2 ADTAB CLAPA2 HIP9 HYPJ KIAA0899 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667] clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901] ALLLSTYIKFVNLFPEVKPTIQDVLR;LINNAIK 2 3.5 0.84121 -0.043106 0 0 0 0 0 0 0 0 0 0 0 7.81019 O94979 SC31A_HUMAN Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; response to calcium ion [GO:0051592] COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120] calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198] AQGEPVAGHESPK;KITKKPIPDEHLILK;LVLLSIVLLK;LVLLSIVLLKVTVPK;LVTFENVR;MVKLVLLSIVLLKVTVPK;VKLVLLSIVLLK;VKLVLLSIVLLKVTVPK 8 5.6 0.26533 0.26459 9.8401 4.27292 0 7.60615 7.12298 6.91576 0 0 3.68896 0 10.8492 0 O94979 SC31A_HUMAN Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; response to calcium ion [GO:0051592] COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120] calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198] AQGEPVAGHESPK;FASSPLR;KITKKPIPDEHLILK;LVTFENVR;MLGESDERCTNAGSGCRR;VLENHAR 6 5.7 0.95331 -0.73051 0 0 0 0 0 0 0 0 0 5.84952 11.4794 0 O94983 CMTA2_HUMAN Calmodulin-binding transcription activator 2 CAMTA2 KIAA0909 Homo sapiens (Human) cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ELYEAAR;VIQTAFRKYK 2 1.4 0.86429 -0.089719 0 0 0 0 0 0 0 0 0 0 4.33885 0 O94985 CSTN1_HUMAN Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] CLSTN1 CS1 KIAA0911 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558]; regulation of synapse maturation [GO:0090128]; vesicle-mediated transport in synapse [GO:0099003] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988] GVQIQAHPSQLVLTLEGEDLGELDK;HHYSLYVHGCRLIFLFRQDPSEEK;LIFLFRQDPSEEK;NTEKLNYGKEHQYK;QDPSEEK 5 6.4 0.9167 -0.40982 0 0 7.45409 0 5.93805 0 11.4892 0 0 0 10.2469 0 O94986 CE152_HUMAN Centrosomal protein of 152 kDa (Cep152) CEP152 KIAA0912 Homo sapiens (Human) cell projection organization [GO:0030030]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099] protein kinase binding [GO:0019901] KIEDLHQVKK;LEKTEIINKLTR;NLDATVTALK;QVEIAVQNAHQR 4 2.6 0.97213 -2.7963 0 0 11.6212 12.669 12.4993 12.381 12.9282 0 0 9.84793 0 12.824 O94988 FA13A_HUMAN Protein FAM13A FAM13A FAM13A1 KIAA0914 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] DMTKDQIANEKVALQK;SNTLPKSFGSQLEKEDEK 2 3.3 0.97322 -2.4846 0 0 0 9.88528 0 0 0 0 0 0 0 0 O94989 ARHGF_HUMAN Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) ARHGEF15 KIAA0915 Homo sapiens (Human) negative regulation of synapse maturation [GO:2000297]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of catalytic activity [GO:0050790]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] CERLPLPSFLLLPFQR;KLLPLLKPPKPTR;LLPLLKPPKPTR;MKQTEELIRLTQR;SLRLLTDTFVLSQALR 5 6.9 0.97489 -2.3701 6.13877 0 0 7.4358 7.97608 7.73748 12.3718 9.40276 0 0 5.66018 0 O94991 SLIK5_HUMAN SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11) SLITRK5 KIAA0918 LRRC11 Homo sapiens (Human) "adult behavior [GO:0030534]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; circulatory system development [GO:0072359]; dendrite morphogenesis [GO:0048813]; grooming behavior [GO:0007625]; positive regulation of synapse assembly [GO:0051965]; regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0150035]; response to xenobiotic stimulus [GO:0009410]; skin development [GO:0043588]; striatum development [GO:0021756]; synaptic membrane adhesion [GO:0099560]" glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235] LNVEPDYLEVLEK 1 1.4 0.008547 0.99478 13.7014 0 0 13.2294 12.8722 13.0848 11.9802 13.1622 13.1258 0 0 13.876 O94992 HEXI1_HUMAN Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) HEXIM1 CLP1 EDG1 HIS1 MAQ1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of signal transduction by p53 class mediator [GO:1901798] 7SK snRNP [GO:0120259]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; P-TEFb complex binding [GO:0106140]; protein kinase inhibitor activity [GO:0004860]; snRNA binding [GO:0017069]; transcription regulator inhibitor activity [GO:0140416] EYLELEK;KRHWKPYYK;TGLYSKRAAAK;VPEEDSR 4 9.5 0.97359 -2.4747 0 9.85534 0 12.352 0 0 0 0 0 0 0 0 O94993 SOX30_HUMAN Transcription factor SOX-30 SOX30 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proacrosomal vesicle fusion [GO:0120211]; regulation of transcription by RNA polymerase II [GO:0006357]; response to corticosteroid [GO:0031960]; spermatid development [GO:0007286] chromatin [GO:0000785]; chromocenter [GO:0010369]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DYSSECTHSENSR;EYSSVSPCPR 2 3.1 0.78293 0.02085 0 0 0 0 0 4.97357 0 0 0 4.58538 0 0 O94993 SOX30_HUMAN Transcription factor SOX-30 SOX30 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proacrosomal vesicle fusion [GO:0120211]; regulation of transcription by RNA polymerase II [GO:0006357]; response to corticosteroid [GO:0031960]; spermatid development [GO:0007286] chromatin [GO:0000785]; chromocenter [GO:0010369]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TGTQNMR 1 1.4 0.90889 -0.31445 0 6.41478 0 0 0 0 0 0 0 0 0 0 O95007 OR6B1_HUMAN Olfactory receptor 6B1 (Olfactory receptor 7-3) (OR7-3) (Olfactory receptor OR7-9) OR6B1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ELENQTR;ELENQTRVTK;VIHAFNMNK 3 6.1 0.98016 -2.0054 0 10.1539 0 11.3655 0 0 0 0 0 0 0 0 O95025 SEM3D_HUMAN Semaphorin-3D SEMA3D UNQ760/PRO1491 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] AEHEEGK;DLLAESR;DPYCAWDGNACSR;VVSISKEK 4 4.5 0.97854 -1.9748 0 0 0 5.55474 7.83042 0 4.59616 0 0 8.84884 0 8.89215 O95049 ZO3_HUMAN Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP3 ZO3 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] GLRRGAK;QDSMRTYER;TISEPDEQRSELPR 3 3.3 0.97653 -2.178 6.86295 0 0 0 0 0 0 9.43283 0 9.839 0 0 O95067 CCNB2_HUMAN G2/mitotic-specific cyclin-B2 CCNB2 Homo sapiens (Human) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/MI transition of meiotic cell cycle [GO:0008315]; in utero embryonic development [GO:0001701]; regulation of growth [GO:0040008]; spindle assembly involved in female meiosis I [GO:0007057]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538] centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634] cadherin binding [GO:0045296]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] ELKFELGRPLPLHFLR;VAAAASCLSQKVLGQGK 2 8.3 0.89703 -0.25071 0 3.80002 0 0 0 9.01081 0 0 0 0 0 0 O95069 KCNK2_HUMAN Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK1) (Two pore potassium channel TPKC1) (K2P2.1) KCNK2 TREK TREK1 Homo sapiens (Human) "cardiac ventricle development [GO:0003231]; cellular response to arachidonate [GO:1904551]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission, postsynaptic [GO:0099565]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; neuronal action potential [GO:0019228]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transmembrane transport [GO:0071805]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to axon injury [GO:0048678]" apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; voltage-gated potassium channel complex [GO:0008076] identical protein binding [GO:0042802]; ligand-gated channel activity [GO:0022834]; mechanosensitive potassium channel activity [GO:0098782]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel inhibitor activity [GO:0019870]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982] WKTVSTIFLVVVLYLIIGATVFK 1 5.4 0.83366 -0.029624 0 0 0 5.8031 0 0 0 0 0 0 0 0 O95070 YIF1A_HUMAN Protein YIF1A (54TMp) (YIP1-interacting factor homolog A) YIF1A 54TM HYIF1P YIF1 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] DAPLPPR;YVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLR 2 15.7 0.97092 -1.3416 0 0 0 0 0 0 10.8216 0 0 0 0 0 O95071 UBR5_HUMAN "E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)" UBR5 EDD EDD1 HYD KIAA0896 Homo sapiens (Human) cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; negative regulation of smoothened signaling pathway [GO:0045879]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus [GO:0042307]; progesterone receptor signaling pathway [GO:0050847]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] AAVIIMAVEKQTLMQHILR;CATTPMAVHR;DCMGGIR;DLLIQQTMR;LYVPLYSSK;RTSPTAYCDCWEKCK;TLIAGQK 7 2.7 0.97872 -1.9867 0 0 0 8.75104 0 0 10.8987 0 0 7.57372 4.30495 6.55574 O95072 REC8_HUMAN Meiotic recombination protein REC8 homolog (Cohesin Rec8p) REC8 REC8L1 Homo sapiens (Human) double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]; oocyte maturation [GO:0001556]; reciprocal meiotic recombination [GO:0007131]; seminiferous tubule development [GO:0072520]; sister chromatid cohesion [GO:0007062]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] kinetochore [GO:0000776]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634] chromatin binding [GO:0003682] ELPEVSRR 1 1.5 0.83968 -0.043952 0 0 0 5.43856 0 0 0 0 0 0 0 0 O95073 FSBP_HUMAN Fibrinogen silencer-binding protein FSBP Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] ILEEHTNK;MTSSPSSIPR;RQQLEEELLR 3 9.4 0.98068 -1.8004 0 0 0 0 0 0 11.7364 0 9.8115 0 0 0 O95076 ALX3_HUMAN Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3) ALX3 Homo sapiens (Human) embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; pattern specification process [GO:0007389]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" NPFTAAYDISVLPR;VKPKEPPGLLNWTT 2 8.2 0.95502 -0.97219 0 0 0 0 0 0 0 11.8889 0 0 0 11.6225 O95081 AGFG2_HUMAN Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R) AGFG2 HRBL RABR Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] RWPDTFPRR 1 5.8 0.82563 -0.020115 0 0 0 0 9.28082 0 0 0 0 0 0 0 O95084 PRS23_HUMAN Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13) PRSS23 ZSIG13 UNQ270/PRO307 Homo sapiens (Human) proteolysis [GO:0006508] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] serine-type endopeptidase activity [GO:0004252] VGFLKPKFKDGGR 1 3.4 0.87007 -0.094453 0 0 0 0 0 3.89443 0 0 0 0 0 0 O95104 SCAF4_HUMAN "SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)" SCAF4 KIAA1172 SFRS15 Homo sapiens (Human) "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] VLNLWQKNGVFK 1 1 0.88698 -0.18572 0 0 0 0 0 0 0 0 0 8.40654 0 0 O95125 ZN202_HUMAN Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) ZNF202 ZKSCAN10 Homo sapiens (Human) lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleolus [GO:0005730] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CMECGKSYTR 1 1.5 0.88603 -0.19397 0 0 0 0 0 0 0 0 0 5.99991 0 0 O95139 NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit) NDUFB6 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] MVHGVYKK;RWLKDQELSPR;SIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEK 3 40.6 0.9017 -0.26224 0 0 0 7.1813 9.73464 0 7.75295 0 0 0 0 0 O95140 MFN2_HUMAN Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) MFN2 CPRP1 KIAA0214 Homo sapiens (Human) aerobic respiration [GO:0009060]; apoptotic process [GO:0006915]; blastocyst formation [GO:0001825]; camera-type eye morphogenesis [GO:0048593]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; mitochondrion localization [GO:0051646]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986]; type 2 mitophagy [GO:0061734] cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; ubiquitin protein ligase binding [GO:0031625] FEECISQSAVKTKFEQHTVR;MFEFQNFERR 2 4 0.22709 0.30186 0 5.2317 0 8.2771 0 0 0 0 0 0 0 0 O95149 SPN1_HUMAN Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; protein complex oligomerization [GO:0051259]; protein import into nucleus [GO:0006606]; protein tetramerization [GO:0051262]; RNA import into nucleus [GO:0006404]; snRNA import into nucleus [GO:0061015] cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339] LLELQKSK 1 2.2 0.98063 -1.6086 0 10.3374 0 0 0 0 0 0 0 0 0 0 O95153 RIMB1_HUMAN Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) TSPOAP1 BZRAP1 KIAA0612 RBP1 RIMBP1 Homo sapiens (Human) regulation of neurotransmitter secretion [GO:0046928] calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739] benzodiazepine receptor binding [GO:0030156]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626] GLVPSNFVER;LEERARK;LFSIPEEEEEEEEDEEEEK;LQETNLR;VWGFFSKGK 5 2.7 0.97404 -3.0324 0 0 13.395 0 0 0 9.92196 0 0 4.55667 0 0 O95154 ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 (EC 1.-.-.-) (AFB1 aldehyde reductase 2) (AFB1-AR 2) AKR7A3 AFAR2 Homo sapiens (Human) aldehyde metabolic process [GO:0006081] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794] aldo-keto reductase (NADPH) activity [GO:0004033]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802] FYAFNPLAGGLLTGK;LGGSDCRVK 2 7.3 0.96796 -1.3251 0 0 0 0 0 0 10.5471 0 0 0 0 0 O95155 UBE4B_HUMAN Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) UBE4B HDNB1 KIAA0684 UFD2 Homo sapiens (Human) ERAD pathway [GO:0036503]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] enzyme binding [GO:0019899]; ubiquitin-ubiquitin ligase activity [GO:0034450] DLKVENPEKYGFEPK;EELSADEIR;EQIQAWMREK;ETDMLNYLIECFDRVGIEEKK 4 4.2 0.97266 -2.6136 0 0 0 0 7.94363 5.25126 0 0 0 0 0 0 O95166 GBRAP_HUMAN Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46) GABARAP FLC3B HT004 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to nitrogen starvation [GO:0006995]; chemical synaptic transmission [GO:0007268]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; microtubule cytoskeleton organization [GO:0000226]; mitophagy [GO:0000423]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein targeting [GO:0006605]; protein transport [GO:0015031]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020] actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; sperm midpiece [GO:0097225] beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625] IGDLDKK;KFVYKEEHPFEK;RRSEGEK 3 22.2 0.97833 -1.9342 0 10.8354 0 11.2047 11.3286 0 11.91 12.0733 0 0 0 0 O95171 SCEL_HUMAN Sciellin SCEL Homo sapiens (Human) embryo development ending in birth or egg hatching [GO:0009792]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; response to mechanical stimulus [GO:0009612] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872] ISDRNDAAK;NISEELDNLIK;NQGLDSLFRANPKVEER;QNLESVAKVNAR;REPGVHPPIPPKPSSPVSSPNQLR;TYKANTLDNQLTNR;VNERDVPK;VNERDVPKATISR;YIQTVYSTSDR 9 16.6 0.97613 -5.271 0 4.40905 3.69855 0 9.16 10.2502 9.61086 0 0 8.22694 9.77658 12.1471 O95180 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; cellular response to hormone stimulus [GO:0032870]; cellular response to potassium ion [GO:0035865]; cortisol biosynthetic process [GO:0034651]; inorganic cation transmembrane transport [GO:0098662]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; positive regulation of acrosome reaction [GO:2000344]; regulation of heart contraction [GO:0008016]; regulation of membrane potential [GO:0042391] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic ion channel activity [GO:0005244] ESLLSGEGK;ILGVLRVLRLLR;IVDSKYFSR;LLRTLRPLRVISR;LLRVLKLVR;LVRFLPALRR;NISTKAQCR;SCPYCTR;VLKLVRFLPALR;VLRLLRTLRPLR 10 3.1 0.95309 -0.77726 0 6.27659 4.46146 0 5.72066 6.05637 13.1984 7.91558 0 7.47046 4.70543 0 O95183 VAMP5_HUMAN Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) VAMP5 HSPC191 Homo sapiens (Human) cell differentiation [GO:0030154]; Golgi to plasma membrane protein transport [GO:0043001]; muscle organ development [GO:0007517]; skeletal muscle tissue development [GO:0007519] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LAELQQR;MAGIELERCQQQANEVTEIMRNNFGK;TTQNLAQKKCWENIR 3 41.4 0.084112 0.38358 10.1797 0 0 0 0 0 10.1975 0 0 0 0 0 O95185 UNC5C_HUMAN Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) UNC5C UNC5H3 Homo sapiens (Human) anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; brain development [GO:0007420]; chemorepulsion of axon [GO:0061643]; dorsal root ganglion development [GO:1990791]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; regulation of neuron migration [GO:2001222] cell surface [GO:0009986]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] netrin receptor activity [GO:0005042]; netrin receptor activity involved in chemorepulsion [GO:0005043]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631] KTFEQEPLGK 1 1.1 0.7355 0.11168 0 0 0 0 9.53728 0 0 0 0 0 0 0 O95197 RTN3_HUMAN Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) RTN3 ASYIP NSPL2 Homo sapiens (Human) apoptotic process [GO:0006915]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] LLTDFSVHDLIFWRDVK;NPNGVSSREAK 2 2.7 0.97937 -1.9982 8.17597 0 0 0 9.46765 0 0 0 0 0 0 0 O95198 KLHL2_HUMAN Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726] actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EVDGWTLR;TVDSYDPVK;VVLAACSPYFHAMFTGEMSESRAKR 3 7.1 0.9767 -2.192 0 0 0 8.73132 0 0 0 0 0 9.91019 0 0 O95201 RHIT_HUMAN Transcriptional repressor RHIT (Repressor of heat-inducible transcription) (RhitH) (Zinc finger protein 205) (Zinc finger protein 210) ZNF205 RHIT ZNF210 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] mitochondrion [GO:0005739]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" GVRPYACPLCGKSFSRR;SDLVTHQGTHTGAKPHKCPICAK 2 7.2 0.98012 -1.6517 0 0 0 0 10.4475 0 0 0 0 9.68278 0 0 O95202 LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) LETM1 Homo sapiens (Human) calcium export from the mitochondrion [GO:0099093]; calcium ion transport [GO:0006816]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; ribosome binding [GO:0043022] AAKGSATK;GWHSSRPVRDDSVVEKSLK;HYYHGFRLLWIDTK;VLDELKHYYHGFR 4 6.4 0.92131 -0.44436 0 10.2572 0 0 0 0 10.2507 0 10.3903 0 0 0 O95206 PCDH8_HUMAN Protocadherin-8 (Arcadlin) PCDH8 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; morphogenesis of embryonic epithelium [GO:0016331]; regulation of synaptic membrane adhesion [GO:0099179]; somitogenesis [GO:0001756] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509] EPAPPVAVWKGHSFNTISGREAEK;GPAAPASAGSPER;LPDLQEIGVPLYQSPPGR;LTLAGPVDYER;VLHRDYDR 5 6.9 0.98114 -2.0295 0 0 0 6.36756 9.19345 0 0 9.36702 0 0 12.773 0 O95208 EPN2_HUMAN Epsin-2 (EPS-15-interacting protein 2) EPN2 KIAA1065 Homo sapiens (Human) endocytosis [GO:0006897]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of Notch signaling pathway [GO:0045747] clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] EVAEQEER 1 1.2 0.91349 -0.39033 0 0 0 0 0 7.19859 0 0 7.18765 0 0 0 O95210 STBD1_HUMAN Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) STBD1 GENX-3414 Homo sapiens (Human) glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; intracellular transport [GO:0046907]; substrate localization to autophagosome [GO:0061753] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; tertiary granule membrane [GO:0070821] cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; polysaccharide binding [GO:0030247]; starch binding [GO:2001070] EVCDNSR;WNTYIPLHYNK 2 5 0.93653 -0.5457 0 0 7.09887 0 0 0 8.36851 0 0 0 0 4.73428 O95218 ZRAB2_HUMAN "Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing)" ZRANB2 ZIS ZNF265 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654] lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] SSSSGDRK;YRGKAVGPASILK 2 6.4 0.91536 -0.37628 0 9.56828 9.59404 0 0 7.20819 0 0 0 0 0 0 O95219 SNX4_HUMAN Sorting nexin-4 SNX4 Homo sapiens (Human) endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201] epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; transferrin receptor binding [GO:1990459] DKIFYLFLTQEGNWK;IGLENFLLRIASHPILCRDK;KIEISVSEAEK 3 9.8 0.84424 -0.055488 0 0 0 0 0 0 0 0 9.19173 0 6.28653 0 O95221 OR5F1_HUMAN Olfactory receptor 5F1 (Olfactory receptor 11-10) (OR11-10) (Olfactory receptor OR11-167) OR5F1 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] MLADLLSEK;YAAICRPLLYSLIMSRTVYLK 2 9.6 0.95367 -0.9284 0 0 0 12.1997 9.27857 0 0 0 0 0 0 0 O95229 ZWINT_HUMAN Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) ZWINT Homo sapiens (Human) cell division [GO:0051301]; establishment of localization in cell [GO:0051649]; homologous chromosome orientation in meiotic metaphase I [GO:0031619]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; regulation of meiosis I spindle assembly checkpoint [GO:1905325] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940] AIAAKEQWKELK 1 4.3 0.97334 -1.3728 0 0 0 0 0 0 0 0 12.3861 0 0 0 O95231 VENTX_HUMAN Homeobox protein VENTX (VENT homeobox homolog) (VENT-like homeobox protein 2) VENTX HPX42B VENTX2 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GLCAMPQTGDAF 1 4.7 0.80661 0.012184 0 0 0 0 0 0 0 0 0 0 5.8522 0 O95232 LC7L3_HUMAN Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) LUC7L3 CREAP1 CROP O48 Homo sapiens (Human) mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ATVEELKEK;HSSRTSDRR;QEREEREK 3 6 0.97355 -2.9798 0 0 0 9.3898 0 8.46095 0 0 0 0 0 0 O95235 KI20A_HUMAN Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) KIF20A MKLP2 RAB6KIFL Homo sapiens (Human) microtubule bundle formation [GO:0001578]; microtubule-based movement [GO:0007018]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901] EQWCSEHLDTQK;IENVETLVLQAPK;ISELSLCDLAGSERCKDQK;LGTNQENQQPNQQPPGK 4 6.9 0.76792 0.058679 0 0 0 10.1594 0 7.92131 0 0 0 8.24745 8.55052 0 O95236 APOL3_HUMAN Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289]; lipid transporter activity [GO:0005319] LKVFKEVMR;TIAGTTR;TYAAIEDEYVQQK 3 7.2 0.97649 -2.2684 0 0 0 0 10.5127 0 0 0 0 0 8.69867 0 O95237 LRAT_HUMAN Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) LRAT Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of lipid transport [GO:0032370]; response to bacterium [GO:0009617]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791] acyltransferase activity [GO:0016746]; O-palmitoyltransferase activity [GO:0016416]; phosphatidylcholine-retinol O-acyltransferase activity [GO:0047173]; retinoic acid binding [GO:0001972]; retinol binding [GO:0019841] RLILGVIVKVASIR 1 6.1 0.87013 -0.091047 0 0 0 5.14568 0 0 0 0 0 0 0 0 O95239 KIF4A_HUMAN Chromosome-associated kinesin KIF4A (Chromokinesin-A) KIF4A KIF4 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; spindle elongation [GO:0051231] axon cytoplasm [GO:1904115]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; midbody [GO:0030496]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876] ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AQINIREDPKEGIK;DALQKQREVADK;GLLCLGNVISALGDDK;GLLEARSSRPAWATWR;QLEESVSEK;VQLMRQMK;VSYLEIYNEEILDLLCPSREK 7 8.5 0.96121 -1.0642 0 0 0 6.1335 0 0 0 0 0 10.179 6.62907 0 O95243 MBD4_HUMAN Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) MBD4 MED1 Homo sapiens (Human) depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696] EALSPPR;GSEMDNNCSPTRKDFTGEK;IFCVNEWKQVHPEDHK 3 7.2 0.91567 -0.43095 0 7.23381 0 0 0 0 0 0 0 0 0 0 O95243 MBD4_HUMAN Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) MBD4 MED1 Homo sapiens (Human) depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696] EALSPPR;GSEMDNNCSPTRKDFTGEK;LTPIHNSAHLVSEAK 3 7.2 0.91555 -0.36684 0 0 6.60213 0 9.68342 0 0 0 8.22333 0 0 0 O95248 MTMR5_HUMAN Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1) SBF1 MTMR5 Homo sapiens (Human) protein dephosphorylation [GO:0006470]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471] guanyl-nucleotide exchange factor activity [GO:0005085]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] DYQRLGLGTLSSSLSRAK;GSGEGQGQILQR;KLLPAVLRALK;MLEAKKLLPAVLR;SGGLHGK 5 2.8 0.9727 -2.6654 0 0 9.22949 3.92372 8.17203 0 0 0 0 0 0 0 O95251 KAT7_HUMAN "Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)" KAT7 HBO1 HBOa MYST2 Homo sapiens (Human) "DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin disassembly [GO:0140889]; internal peptidyl-lysine acetylation [GO:0018393]; natural killer cell differentiation [GO:0001779]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of protein localization to nucleus [GO:1900182]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to actinomycin D [GO:0072716]; response to anisomycin [GO:0072739]; response to dithiothreitol [GO:0072720]; response to hydroxyurea [GO:0072710]; response to sorbitol [GO:0072708]; stress-activated protein kinase signaling cascade [GO:0031098]; transcription initiation-coupled chromatin remodeling [GO:0045815]" "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; histone H3-K14 acetyltransferase complex [GO:0036409]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]" chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] ASEDLEKLR;HLVLKRQDLIDEWIAK;KNKIYCQNLCLLAK;LYMCEFCLKYMK;NKIYCQNLCLLAKLFLDHK;QDLIDEWIAKEAKR 6 10 0.97271 -2.6687 0 10.8165 0 0 10.5225 4.56682 11.2922 0 0 8.97051 0 0 O95255 MRP6_HUMAN ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6) ABCC6 ARA MRP6 Homo sapiens (Human) ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion homeostasis [GO:0055074]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; leukotriene transport [GO:0071716]; phosphate ion homeostasis [GO:0055062]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; visual perception [GO:0007601] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626] AGWPAGK;AGWPAGKDSIQYGRVK;APETEPFLR;FHGWEGAFLDRVLGIR;SPISFFERTPIGHLLNR 5 3.9 0.97269 -2.5992 0 0 0 0 0 10.3328 10.6705 0 0 9.42756 0 11.2578 O95256 I18RA_HUMAN Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) IL18RAP IL1R7 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell population proliferation [GO:0008283]; cellular response to hydrogen peroxide [GO:0070301]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; neutrophil activation [GO:0042119]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] cell surface [GO:0009986]; interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886] "coreceptor activity [GO:0015026]; interleukin-18 receptor activity [GO:0042008]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" LLWTYSTR;MLCLGWIFLWLVAGERIK;VLPTVTWRGLK 3 6.2 0.98091 -1.6878 0 0 0 9.28568 8.70964 8.63008 9.43235 0 11.8153 7.17911 0 0 O95258 UCP5_HUMAN Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14) SLC25A14 BMCP1 UCP5 UNQ791/PRO1682 Homo sapiens (Human) aerobic respiration [GO:0009060]; inorganic anion transport [GO:0015698]; regulation of cellular response to oxidative stress [GO:1900407] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857] GIFPGIILIFLRVK;GMFHALFRICK 2 7.7 0.95371 -0.89531 0 0 0 0 0 0 0 0 0 5.47787 0 8.18597 O95259 KCNH1_HUMAN Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) KCNH1 EAG EAG1 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; myoblast fusion [GO:0007520]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of cell population proliferation [GO:0042127]; regulation of membrane potential [GO:0042391] axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; phosphatidylinositol bisphosphate binding [GO:1902936] FKDACGK;GGGGDCAK;LTRALTSSRGVLQQLAPSVQK;VLEFYTAFSHSFSR 4 5.1 0.9777 -1.5175 0 11.4298 0 0 0 0 4.71194 0 11.82 0 0 0 O95260 ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Homo sapiens (Human) proteasomal protein catabolic process [GO:0010498]; protein arginylation [GO:0016598]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634] arginyl-tRNA--protein transferase activity [GO:0004057] AIMPYGVYK 1 1.7 0.90938 -0.31602 0 0 0 0 0 0 0 0 0 9.55334 0 0 O95263 PDE8B_HUMAN "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)" PDE8B PIG22 Homo sapiens (Human) behavioral fear response [GO:0001662]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of steroid hormone biosynthetic process [GO:0090032]; neuromuscular process controlling balance [GO:0050885]; operant conditioning [GO:0035106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; visual learning [GO:0008542] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" EDSQSDGFWWACDRAGYR;ELADLPK;ISEEYFAQTDEEKR;NFPENQILIKR;TLDDLKCKSLR 5 6.9 0.9461 -0.65611 9.03774 0 0 0 0 0 11.8509 0 9.36238 6.76062 0 11.9093 O95267 GRP1_HUMAN RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) RASGRP1 RASGRP Homo sapiens (Human) activation of GTPase activity [GO:0090630]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; cell differentiation [GO:0030154]; inflammatory response to antigenic stimulus [GO:0002437]; mast cell degranulation [GO:0043303]; natural killer cell activation [GO:0030101]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell differentiation in thymus [GO:0033089]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; secretory granule localization [GO:0032252]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell proliferation [GO:0042098]; vesicle transport along microtubule [GO:0047496] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; zinc ion binding [GO:0008270] CKDCGMNCHKQCK;DCGMNCHK;DWSRKLTQR;EGLISRDEITAYFMR;SNQLLQVMLTMHR 5 6.3 0.95144 -0.69549 0 0 8.47836 0 0 6.45779 9.81578 8.88557 0 6.5159 0 5.39352 O95271 TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) "cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]" histone binding [GO:0042393]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270] GANVNEKNK;LVDAANVNAK;VQKLCTPENINCR 3 2.4 0.96497 -1.1514 8.8704 0 0 0 11.1394 0 0 0 4.73091 0 0 0 O95273 CCDB1_HUMAN Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid) CCNDBP1 DIP1 GCIP HHM Homo sapiens (Human) cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LVSVLKKALEITK;VGEAQETTEEFNREMFWR 2 8.6 0.87372 -0.11863 4.34611 0 0 0 0 4.99386 0 0 0 0 0 0 O95274 LYPD3_HUMAN Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4) LYPD3 C4.4A UNQ491/PRO1007 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; negative regulation of smooth muscle cell apoptotic process [GO:0034392] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] laminin binding [GO:0043236] CNAKLNLTSR 1 2.9 0.88815 -0.18447 0 7.21053 0 0 0 0 0 0 0 0 0 0 O95292 VAPB_HUMAN Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) VAPB UNQ484/PRO983 Homo sapiens (Human) cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intracellular calcium ion homeostasis [GO:0006874]; IRE1-mediated unfolded protein response [GO:0036498]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of viral genome replication [GO:0045070]; suppression of viral release by host [GO:0044790]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495] EAKPEDLMDSKLR;EEGLSTRLLALVVLFFIVGVIIGK;KVMEECKR;LLALVVLFFIVGVIIGK;LLALVVLFFIVGVIIGKIAL 5 19.8 0.88091 -0.15997 0 6.19751 7.28605 7.64875 5.33264 7.03584 10.15 0 0 5.58862 5.58334 0 O95294 RASL1_HUMAN RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein) RASAL1 RASAL Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of dendrite extension [GO:1903861]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] LAFKQLHRR;VEERFPQAEHQDVKYLAISGFLFLR;VELWDWDMVGK 3 5.6 0.97455 -1.4285 0 0 0 0 0 0 7.62213 0 0 10.7442 0 0 O95295 SNAPN_HUMAN SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) SNAPIN BLOC1S7 SNAP25BP SNAPAP Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; lysosomal lumen acidification [GO:0007042]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; melanosome organization [GO:0032438]; negative regulation of neuron projection development [GO:0010977]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neurotransmitter secretion [GO:0007269]; organelle transport along microtubule [GO:0072384]; positive regulation of late endosome to lysosome transport [GO:1902824]; protein maturation [GO:0051604]; protein-containing complex localization [GO:0031503]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; regulation of protein binding [GO:0043393]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde axonal transport [GO:0008090]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle transport [GO:0048489]; terminal button organization [GO:0072553] acrosomal vesicle [GO:0001669]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; manchette [GO:0002177]; microvesicle [GO:1990742]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] SNARE binding [GO:0000149] RVVLVNNILQNAQERLR 1 12.5 0.5336 0.18636 0 0 0 0 0 0 0 0 0 3.88235 0 0 O95298 NDUC2_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b) NDUFC2 HLC1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] QLLYITAFFFAGYYLVKREDYLYAVR 1 21.8 0.68368 0.16504 0 5.60434 0 0 0 0 0 0 10.7614 0 0 0 O95302 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase) FKBP9 FKBP60 FKBP63 Homo sapiens (Human) protein folding [GO:0006457] endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] DSTFNVFVGK;FVPDECPRTVR;GVGIYWK;IVVPPHLGYGEEGR;VQNHGLSYDRDSTFNVFVGK;VTAEEFK;VTAEEFKLKDQEAK 7 10.6 0.97356 -2.5531 5.97694 0 0 0 0 0 0 13.2 13.2289 0 7.87172 0 O95336 6PGL_HUMAN 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) PGLS Homo sapiens (Human) "carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]" cytosol [GO:0005829]; extracellular exosome [GO:0070062] 6-phosphogluconolactonase activity [GO:0017057] ELPAAVAPAGPASLAR;ILEDQEENPLPAALVQPHTGK;LLTVPFEKHSTL;TVIFVATGEGK;VTLTLPVLNAAR 5 27.9 0.012121 0.84175 0 0 0 0 0 0 0 0 9.65614 11.5403 9.6492 8.79779 O95340 PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] PAPSS2 ATPSK2 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; blood coagulation [GO:0007596]; bone development [GO:0060348]; hormone metabolic process [GO:0042445]; sulfate assimilation [GO:0000103] cytosol [GO:0005829] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781] AEAETLPSLSITK;VAAYNKAK 2 3.4 0.9365 -0.54692 0 0 0 0 0 0 0 0 0 0 11.9953 0 O95342 ABCBB_HUMAN Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11) ABCB11 BSEP Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; canalicular bile acid transport [GO:0015722]; cholesterol homeostasis [GO:0042632]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; phospholipid homeostasis [GO:0055091]; positive regulation of bile acid secretion [GO:0120189]; protein ubiquitination [GO:0016567]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid beta-oxidation [GO:0031998]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular canaliculus [GO:0046581]; intracellular canaliculus [GO:0046691]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ABC-type bile acid transporter activity [GO:0015432]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bile acid transmembrane transporter activity [GO:0015125]; canalicular bile acid transmembrane transporter activity [GO:0015126]; carbohydrate transmembrane transporter activity [GO:0015144] TVAAFGGEKREVER 1 1.1 0.95416 -0.91542 0 0 0 0 0 0 0 0 0 10.5078 0 0 O95347 SMC2_HUMAN Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) SMC2 CAPE SMC2L1 PRO0324 Homo sapiens (Human) cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697] ALNHEIEELEKRK;DQEALEAVKR;FQELKDVQDELR;IKELDHNISKHK;SIILEGFKSYAQR;SKAKPPKGAHVEV;VIKLQEELSENDK;VMREIEHLSR 8 8 0.97816 -6.1922 7.95321 0 0 0 0 9.35005 12.3092 12.4213 14.5867 9.97814 7.01212 0 O95352 ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) ATG7 APG7L Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; cellular response to stress [GO:0033554]; defense response to virus [GO:0051607]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagophore assembly site [GO:0000407]; secretory granule lumen [GO:0034774] Atg12 activating enzyme activity [GO:0019778]; Atg8 activating enzyme activity [GO:0019779]; protein homodimerization activity [GO:0042803] AVGWEKNQK;LPEMAFSPDCPKAVGWEK 2 3 0.97867 -1.9743 0 7.41312 0 9.65006 0 0 0 0 0 0 0 0 O95359 TACC2_HUMAN Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) TACC2 Homo sapiens (Human) cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] nuclear receptor binding [GO:0016922] AQEGESTLEIR;DAPRVMDK;ICDELIAKMGKS;LDRANAEIAQVR;LEFDYSEDK;LPALGEK;NKEIEELTKICDELIAK;NQEGKVNTRR;QQDTPGSPDHR;SLADLFRRYEK 10 3.4 0.97831 -7.6461 14.3364 0 0 0 10.9037 0 10.9252 0 9.73113 9.90844 6.97039 0 O95361 TRI16_HUMAN Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) TRIM16 EBBP Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605] DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] LNENAISRLQANQK 1 2.5 0.92077 -0.43739 6.83365 0 0 0 0 0 0 0 0 0 0 0 O95363 SYFM_HUMAN "Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" FARS2 FARS1 HSPC320 Homo sapiens (Human) phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049] ITYRHMERTLSQR;LFWCEDERFLK;LVEFDLKQTLTR;VLTRVGRNLHNQQHHPLWLIK 4 12.6 0.9808 -1.7326 0 9.0258 9.74302 0 8.61217 0 0 9.04669 0 0 0 0 O95365 ZBT7A_HUMAN Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) ZBTB7A FBI1 LRF ZBTB7 ZNF857A Homo sapiens (Human) "B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; erythrocyte maturation [GO:0043249]; fat cell differentiation [GO:0045444]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to nucleus [GO:0034504]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription regulatory region DNA binding [GO:2000677]" cytoplasm [GO:0005737]; DNA-dependent protein kinase complex [GO:0070418]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription corepressor binding [GO:0001222]" VIQGAGK 1 1.2 0.65974 0.16917 0 0 7.20144 0 12.7222 0 0 0 0 0 0 0 O95373 IPO7_HUMAN Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) IPO7 RANBP7 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267] EVKTSELR;FSAPVVPSSFNFGGPAPGMN;KQLQDIATLADQR;MDPNTIIEALR;QAGVIYLK;QLQDIATLADQRR;VQLTTCIHHIIK;YGSPGNVSK 8 7.9 0.0084746 0.95258 11.1154 9.93072 0 0 0 9.45191 9.03562 9.03796 0 0 11.1787 0 O95376 ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) ARIH2 ARI2 TRIAD1 HT005 Homo sapiens (Human) developmental cell growth [GO:0048588]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] TLLKDFHDT;VQCNRCNEVFCFK 2 4.5 0.95165 -0.71369 0 0 0 0 0 0 4.70332 0 0 0 0 10.0428 O95377 CXB5_HUMAN Gap junction beta-5 protein (Connexin-31.1) (Cx31.1) GJB5 Homo sapiens (Human) cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; epididymis development [GO:1905867]; labyrinthine layer morphogenesis [GO:0060713]; trophoblast giant cell differentiation [GO:0060707] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] IWLSLVFIFRVLVYLVTAER;RCHECLAARK 2 11 0.87289 -0.10958 0 0 0 8.84043 0 0 0 0 0 9.04423 0 0 O95379 TFIP8_HUMAN Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) TNFAIP8 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027] EMLHQIIQRHLTAKSHGR;LLNECREMLHQIIQR 2 12.1 0.6489 0.17058 0 0 0 0 0 8.70929 0 0 0 0 10.5106 0 O95382 M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) MAP3K6 ASK2 MAPKKK6 MEKK6 Homo sapiens (Human) JNK cascade [GO:0007254]; p38MAPK cascade [GO:0038066]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310] CLGAHIHTPNR;LGCLLARKGCVEK;LLEATPTDSCGYFR 3 3 0.96313 -1.087 0 0 12.4717 0 0 5.75122 0 0 0 10.0817 0 0 O95389 CCN6_HUMAN Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3) CCN6 WISP3 UNQ462/PRO790/PRO956 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitochondrion [GO:0005739] growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178] NLPLIWK;VTNENSNCEMRK 2 5.4 0.92383 -0.44772 0 0 0 8.98174 0 0 0 0 0 0 0 0 O95390 GDF11_HUMAN Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11) GDF11 BMP11 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; amacrine cell differentiation [GO:0035881]; camera-type eye morphogenesis [GO:0048593]; cell population proliferation [GO:0008283]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of SMAD protein signal transduction [GO:0060391]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; spinal cord anterior/posterior patterning [GO:0021512]; type B pancreatic cell maturation [GO:0072560]; ureteric bud development [GO:0001657] extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] LESIKSQILSKLR;VLKAQLWVYLRPVPRPATVYLQILR;YPLTVDFEAFGWDWIIAPK 3 14 0.79115 0.016774 9.67894 0 0 0 0 0 0 0 0 6.10379 0 0 O95391 SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (hSlu7) SLU7 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681] pre-mRNA 3'-splice site binding [GO:0030628]; second spliceosomal transesterification activity [GO:0000386]; zinc ion binding [GO:0008270] DHNSEDEDEDK;DRWNGYNPEEHMK;EDFKEQQK;LELLYKSFKVK;LVEQANSPKHQWGEEEPNSQMEK;YRKGACENCGAMTHK 6 13.8 0.9728 -2.6207 0 5.18245 0 10.1475 0 0 0 0 0 10.5213 0 0 O95393 BMP10_HUMAN Bone morphogenetic protein 10 (BMP-10) BMP10 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; heart trabecula formation [GO:0060347]; kidney development [GO:0001822]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; sarcomere organization [GO:0045214]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Z disc [GO:0030018] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; receptor serine/threonine kinase binding [GO:0033612]; telethonin binding [GO:0031433] LEPISILYLDKGVVTYK 1 4 0.95249 -0.68038 0 0 0 0 0 0 0 0 0 0 8.44737 0 O95394 AGM1_HUMAN Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) PGM3 AGM1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glucosamine metabolic process [GO:0006041]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829] magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610] AFVRPSGTEDVVR;DLGAITK;QLKVQVADR;VPVYCTK;YLEEVMK 5 7.9 0.9726 -2.6137 0 8.04532 3.64051 0 0 0 12.1708 0 10.5286 9.31297 9.40996 8.32948 O95398 RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) RAPGEF3 CGEF1 EPAC EPAC1 Homo sapiens (Human) adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; associative learning [GO:0008306]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; intracellular signal transduction [GO:0035556]; negative regulation of syncytium formation by plasma membrane fusion [GO:0034242]; positive regulation of angiogenesis [GO:0045766]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiogenesis [GO:0045765]; regulation of insulin secretion [GO:0050796]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165] endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904] LALAKLSPPVIPFMPLLLK;MRMMARAAR;TDEELDLIFEELLHIK;VGALPDVVPEGTLLNMVLR 4 6.8 0.95389 -0.91584 9.20552 0 0 0 0 0 0 0 0 10.0745 0 0 O95399 UTS2_HUMAN Urotensin-2 (Urotensin II) (U-II) (UII) UTS2 UNQ525/PRO1068 Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; chemical synaptic transmission [GO:0007268]; muscle contraction [GO:0006936]; regulation of blood pressure [GO:0008217] extracellular region [GO:0005576]; extracellular space [GO:0005615]; synapse [GO:0045202] hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] ETPDCFWK;LTPEELER 2 12.9 0.26592 0.26338 0 11.5486 0 0 11.7856 11.1349 11.3389 0 12.3856 0 0 12.2859 O95400 CD2B2_HUMAN CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) CD2BP2 KIAA1178 Homo sapiens (Human) spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682] ribonucleoprotein complex binding [GO:0043021] LGARGGGK 1 2.3 0.91328 -0.33804 0 0 0 0 0 0 0 0 0 8.79666 0 0 O95402 MED26_HUMAN Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) MED26 ARC70 CRSP7 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ADSDAASSGGSDSKKK;ASVLQQLDR 2 4.2 0.91288 -0.38962 0 0 0 0 0 7.21675 0 0 0 9.15175 0 0 O95405 ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) endocytosis [GO:0006897]; endosomal transport [GO:0016197]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904] DFTITCGK;EMKDFTITCGK;IVNYVNRK 3 1.3 0.97786 -1.5278 0 0 0 0 0 0 0 0 0 11.6575 0 8.46013 O95407 TNF6B_HUMAN Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68) TNFRSF6B DCR3 TR6 UNQ186/PRO212 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] extracellular region [GO:0005576]; extracellular space [GO:0005615] signaling receptor activity [GO:0038023] LTELLGAQDGALLVRLLQALRVAR;RDSPTTCGPCPPR 2 12.3 0.95514 -0.94461 0 0 0 0 0 8.47832 0 0 0 0 6.35202 0 O95411 TIAF1_HUMAN Putative TGFB1-induced anti-apoptotic factor 1 (12 kDa TGF-beta-1-induced antiapoptotic factor) MYO18A TIAF1 Homo sapiens (Human) apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of apoptotic process [GO:0043066] nucleus [GO:0005634] NEVRRGSPVLLGWVEQAYADK 1 18.3 0.50503 0.18816 0 0 0 0 6.9305 0 0 0 0 0 0 0 O95415 BRI3_HUMAN Membrane protein BRI3 (Brain protein I3) (pRGR2) BRI3 Homo sapiens (Human) azurophil granule membrane [GO:0035577]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] SSWLYTYPLRVCT 1 13.3 0.95255 -0.67252 0 0 0 0 0 0 0 0 0 11.5049 0 0 O95416 SOX14_HUMAN Transcription factor SOX-14 (Protein SOX-28) SOX14 SOX28 Homo sapiens (Human) brain development [GO:0007420]; entrainment of circadian clock [GO:0009649]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron migration [GO:2001222]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AQHMKEHPDYKYRPR 1 6.2 0.9594 -1.042 0 0 12.4614 0 0 0 0 0 0 0 0 0 O95425 SVIL_HUMAN Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; cell projection [GO:0042995]; cleavage furrow [GO:0032154]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AEEEEGEGEGEEKEEDVCFTEALEQSK;ELELPSSK;ESKYAVPR;FLDWTELKR;HEWFLQK;LTSSVAEHK;TPTGEGLLDSPSK 7 3.7 0.97249 -2.8184 8.98976 8.95545 12.3824 0 0 0 5.4832 7.59216 0 9.2878 0 0 O95428 PPN_HUMAN Papilin PAPLN UNQ2420/PRO4977 Homo sapiens (Human) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] GAEGDLAPERLHAR;LDQNQPR;LLLLVPLLLAPAPGSSAPKVR;SCSSGTR 4 3.8 0.98092 -1.7919 0 10.731 0 0 0 0 8.38931 0 0 9.67352 0 0 O95436 NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) SLC34A2 Homo sapiens (Human) in utero embryonic development [GO:0001701]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; response to estrogen [GO:0043627]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982] phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436] ACCLLCDCPKCCR;CCCCCRVCCRACCLLCDCPK;EAQGEVPASDSK;FTGCFQMRCCCCCRVCCR;LLQSRCPR;VCCRACCLLCDCPKCCR;VITKPFTKLIVQLDK;VLVGVGVPVVFIIILVLCLR 8 12.5 0.89698 -0.25208 0 0 7.09951 6.20081 10.141 5.46287 0 9.29073 5.94186 4.3385 5.89811 12.0877 O95447 LCA5L_HUMAN Lebercilin-like protein (Leber congenital amaurosis 5-like protein) LCA5L C21orf13 Homo sapiens (Human) intraciliary transport [GO:0042073] axoneme [GO:0005930] ILSARLHKIK;LNCRAFSR;SQCSCGSLSSQYDYSEDFLCDCSEK 3 6.4 0.95746 -1.0215 0 4.91428 12.0058 0 0 0 3.89365 0 0 0 0 0 O95450 ATS2_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) ADAMTS2 PCINP PCPNI Homo sapiens (Human) collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GLAAQEAEQGR;HCFKGHCIWLTPDILK;KHGYIKMFEIPAGAR 3 3.5 0.98123 -1.7748 0 0 0 0 0 0 0 0 0 10.5874 7.32211 0 O95453 PARN_HUMAN Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) PARN DAN Homo sapiens (Human) "box H/ACA sno(s)RNA 3'-end processing [GO:0000495]; female gamete generation [GO:0007292]; lncRNA processing [GO:0180035]; miRNA catabolic process [GO:0010587]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of telomere maintenance via telomerase [GO:0032212]; priRNA 3'-end processing [GO:1990431]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA modification [GO:0009451]; siRNA 3'-end processing [GO:1990432]; telomerase RNA stabilization [GO:0090669]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; cation binding [GO:0043169]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; nuclease activity [GO:0004518]; poly(A)-specific ribonuclease activity [GO:0004535]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] REQQKHAK 1 1.3 0.8701 -0.095167 0 0 0 0 0 8.98613 0 0 0 0 0 0 O95455 TGDS_HUMAN "dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46)" TGDS Homo sapiens (Human) nucleotide-sugar metabolic process [GO:0009225] "dTDP-glucose 4,6-dehydratase activity [GO:0008460]" FISLLQHNR 1 2.6 0.9094 -0.31537 0 0 0 0 0 0 0 9.72647 0 0 0 0 O95460 MATN4_HUMAN Matrilin-4 MATN4 Homo sapiens (Human) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509] DQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNK;FVNQIVDFLDVSPEGTR 2 8.5 0.91336 -0.38582 0 0 0 0 0 0 0 0 0 0 11.1942 10.5114 O95461 LARG1_HUMAN "Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)]" LARGE1 KIAA0609 LARGE Homo sapiens (Human) acetylcholine receptor signaling pathway [GO:0095500]; astrocyte differentiation [GO:0048708]; basement membrane organization [GO:0071711]; behavioral fear response [GO:0001662]; blood vessel development [GO:0001568]; bone development [GO:0060348]; cardiac muscle cell development [GO:0055013]; connective tissue development [GO:0061448]; cytoskeleton organization [GO:0007010]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; intracellular protein transport [GO:0006886]; localization of cell [GO:0051674]; long-term synaptic potentiation [GO:0060291]; macrophage differentiation [GO:0030225]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; N-acetylglucosamine metabolic process [GO:0006044]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; neuron migration [GO:0001764]; plasma membrane organization [GO:0007009]; post-embryonic hindlimb morphogenesis [GO:0035129]; post-translational protein modification [GO:0043687]; potassium ion transmembrane transport [GO:0071805]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; protein glycosylation [GO:0006486]; protein localization to plasma membrane [GO:0072659]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]; reactive gliosis [GO:0150103]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; retina layer formation [GO:0010842]; retina vasculature development in camera-type eye [GO:0061298]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle contraction [GO:0006941]; synaptic assembly at neuromuscular junction [GO:0051124]; walking behavior [GO:0090659]; water transport [GO:0006833] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285] AELLSMLDMGTLFTFR;LQMLEAICK;LSFPKSK;QLSELDEDDLCYEFR 4 6.2 0.95227 -0.71925 9.84725 0 0 10.2079 0 0 0 0 0 0 7.14812 0 O95466 FMNL1_HUMAN Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) FMNL1 C17orf1 C17orf1B FMNL FRL1 Homo sapiens (Human) actin filament severing [GO:0051014]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360] bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267] DSELGPGVKAKKPIQTK;EAAAQEAGADTPGKGEPPAPK;EVCGEQHR;GAAYGFR;HLTIKLTPAHSRK;RQQKEPLIYESDR;VAADWMSNLGFKR;VEELEEK 8 9 0.97551 -3.3494 0 0 0 0 0 0 0 0 8.39017 9.62635 8.75338 14.6516 O95470 SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) SGPL1 KIAA1252 Homo sapiens (Human) androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117] AKNYVNGHCTK 1 1.9 0.88344 -0.18021 0 0 0 0 0 0 0 0 0 0 0 8.9116 O95473 SNG4_HUMAN Synaptogyrin-4 SYNGR4 Homo sapiens (Human) neuromuscular junction [GO:0031594]; synaptic vesicle membrane [GO:0030672] VFEGVFSLIVFSSLLTDGYQNK 1 9.4 0.68274 0.1655 0 0 0 0 0 0 0 8.58553 0 0 0 0 O95477 ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of high-density lipoprotein particle assembly [GO:0090107]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]" basolateral plasma membrane [GO:0016323]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905] ALKPLLVGKILYTPDTPATR;FMECVNLNK;FVSPLSWDLVGR;IKDGYWDPGPRADPFEDMR;KGFFAQIVLPAVFVCIALVFSLIVPPFGK;KVLRTLQQIK;LLLYSQKDTSMK;LSDLGISSYGISETTLEEIFLK;LTQQQFVALLWKRLLIAR;NISDYLVK;VLTGTEK;VWFNNKGWHAISSFLNVINNAILRANLQK 12 8.6 0.9756 -4.3766 12.8169 2.68742 10.0104 7.02237 0 0 9.05314 9.78648 4.43816 11.5776 0 9.30538 O95478 NSA2_HUMAN Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 HUSSY-29 Homo sapiens (Human) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] MHEKRNTK;MVTKVCFVGDGFTR 2 8.5 0.93582 -0.53446 8.40901 0 0 0 0 0 10.2372 0 0 0 0 0 O95479 G6PE_HUMAN GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] H6PD GDH Homo sapiens (Human) "glucose metabolic process [GO:0006006]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of cortisol biosynthetic process [GO:2000064]; response to alcohol [GO:0097305]; response to nutrient levels [GO:0031667]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] 6-phosphogluconolactonase activity [GO:0017057]; carbohydrate binding [GO:0030246]; glucose 1-dehydrogenase (NAD+) activity [GO:0047934]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661] DQFLQLSQYR;NLFRPSLPSSWK 2 2.8 0.8505 -0.075148 0 0 6.51095 0 0 0 0 0 0 9.10316 0 0 O95486 SC24A_HUMAN Protein transport protein Sec24A (SEC24-related protein A) SEC24A Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol transport [GO:0032374] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] LFPLFVLALLK;LFPLFVLALLKQK 2 1.2 0.95502 -0.79404 0 0 0 0 0 0 0 0 0 3.87627 0 0 O95490 AGRL2_HUMAN Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524] AALPFGLVR;CFRHSYCCGGLPTESPHSSVKASTTR;DSAGRSYNKLQK;LENINNYR;MWNDTVR;TIISTTSTTSQK 6 5 0.97562 -3.3358 0 0 14.1141 0 0 0 0 0 10.1911 9.69221 9.92762 13.0029 O95497 VNN1_HUMAN Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) VNN1 Homo sapiens (Human) acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; coenzyme A catabolic process [GO:0015938]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pantothenate metabolic process [GO:0015939]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of T cell differentiation in thymus [GO:0033089]; response to oxidative stress [GO:0006979] azurophil granule membrane [GO:0035577]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] pantetheine hydrolase activity [GO:0017159] AFHYDMK;QNLFMGENQFNVPK 2 4.1 0.96566 -1.1233 0 0 0 0 0 0 0 0 0 0 11.0845 0 O95498 VNN2_HUMAN Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2) VNN2 Homo sapiens (Human) pantothenate metabolic process [GO:0015939] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] pantetheine hydrolase activity [GO:0017159] VYHYDMKTELGK 1 2.3 0.98207 -1.588 0 0 0 0 0 0 0 0 0 10.0371 0 0 O95502 NPTXR_HUMAN Neuronal pentraxin receptor NPTXR Homo sapiens (Human) glutamatergic synapse [GO:0098978]; membrane [GO:0016020] metal ion binding [GO:0046872] ALPELYAFTACMWLRSR;LEQELPAR 2 5 0.94643 -0.66163 0 9.00974 0 0 0 0 0 0 0 0 0 0 O95503 CBX6_HUMAN Chromobox protein homolog 6 CBX6 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727] FSESVLR;LIAAFEQKERER 2 4.6 0.98093 -1.7481 0 0 0 0 0 0 0 0 0 9.93402 0 0 O95521 PRAM1_HUMAN PRAME family member 1 PRAMEF1 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IIYLNSIQELEIRNMSWPR;LVAKFSSVFLRLEHLQLLK;YLFQWVYQRR 3 10.1 0.73228 0.11824 9.63523 6.63618 0 0 0 0 9.73985 0 0 9.52442 9.11254 0 O95522 PRA12_HUMAN PRAME family member 12 PRAMEF12 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] KLVLFNIHVSACIPLDR 1 3.5 0.60748 0.17645 0 0 0 0 0 0 0 0 0 0 0 3.54238 O95544 NADK_HUMAN NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase) NADK Homo sapiens (Human) ATP metabolic process [GO:0046034]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD+ kinase activity [GO:0003951] ELCTHLMEAR;MEMEQEKMTMNK;VGSAGGMSR 3 5.2 0.97297 -1.3755 0 0 0 0 7.17073 7.27659 0 0 0 0 11.2007 0 O95561 CA105_HUMAN Uncharacterized protein C1orf105 C1orf105 Homo sapiens (Human) NMNLPILFQVPDVLSKAR 1 9.8 0.9195 -0.43771 0 0 0 4.21708 0 0 0 0 0 0 0 0 O95567 CV031_HUMAN Uncharacterized protein C22orf31 C22orf31 Homo sapiens (Human) ESKESSKEK;NKCCPPPCKFGEGK;VLLPETQK 3 10.7 0.97928 -2.0461 0 0 0 0 0 0 0 0 0 0 9.59272 0 O95573 ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) ACSL3 ACS3 FACL3 LACS3 Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; neuron differentiation [GO:0030182]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of secretion [GO:0051047]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; palmitoyl-CoA ligase activity [GO:0090433]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] GIIVHTMAAVEALGAK;MEQISKGRNTPLCDSFVFR;THYQADIERMYGR;VGAPLVCCEIK 4 8.2 0.97924 -1.9153 10.2769 0 11.2377 0 8.35685 9.4283 0 0 0 0 0 0 O95602 RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) POLR1A Homo sapiens (Human) negative regulation of protein localization to nucleolus [GO:1904750] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; magnesium ion binding [GO:0000287]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] EGEENDDEDMQEER;EGELLCGVLDK;GFTLGVEDILVKPKADVKR;GYLTPTSAR;LFTAYLQLYR;LYLLLRGSCLNCHMLTCPRAVIHLLLCQLR;SQHLHEVLSR;VLRLHYANCK 8 6.6 0.95462 -0.95738 0 0 7.72096 0 0 0 11.1587 0 11.1621 6.1445 6.6157 0 O95613 PCNT_HUMAN Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316]; signal transduction [GO:0007165] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874] calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090] AERKITSRPFTR;EATIAERNLEIDALNQR;ELAEQRAELEKIFQDK;EVEQEQRRR;GALAQGK;GEATATDAEAREAALRK;HLQRESQSAKALEELR;KEDEIQDISLHGGKTQEVPTACPDWR;LAAAASPHSGGR;LEKLLKHHLQK;LGGVLPDSTSK;LLAAEQTVVRDLK;LLSAARLLTSFTSQAVDR;LPPAASEEAHTSNVKMEK;LQSAQAQPFHQEEK;LSLEDGGKGK;LSRQLQVLHQRFLR;NLEIDALNQR;SLCEVQQEVLQLR;TLKEDWESEK;TLSEEQEK;VAQLQEEVEKQKNIVK;VEDLEQLK;VVIAILR;VVIAILRLRFLVK 25 9.3 0.97822 -8.4347 14.6289 12.5001 6.54854 10.3588 11.7997 0 12.4641 11.2054 11.4026 11.5916 10.6358 5.33217 O95619 YETS4_HUMAN YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) YEATS4 GAS41 Homo sapiens (Human) chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; structural constituent of cytoskeleton [GO:0005200] GVTIVKPIVYGNVARYFGKK;LEEDDQAKDI;VVTKPPYEITETGWGEFEIIIK 3 22.9 0.91712 -0.40951 7.31841 0 0 0 0 0 0 0 0 8.72479 10.542 0 O95620 DUS4L_HUMAN tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like) DUS4L Homo sapiens (Human) tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267] ITGTDGVMVAR;LAFRTLVRK;LLSDAAR;TVDLCQK 4 10.7 0.97297 -2.9295 12.8996 0 0 0 0 0 0 0 8.13591 0 0 0 O95622 ADCY5_HUMAN Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ADCY5 Homo sapiens (Human) adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110] AGRIHITK;KPGGAVTPQQQQR 2 1.7 0.91186 -0.32311 0 0 0 0 7.42677 0 0 0 0 0 0 9.84392 O95625 ZBT11_HUMAN Zinc finger and BTB domain-containing protein 11 ZBTB11 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLRQHMNK;GYHCTQCEK;LMEEKQLTVYK;LSEVAEAIQTVK;LSEVAEAIQTVKVEVAHISGGE;RYALIMHK 6 5.5 0.97596 -2.2998 0 0 0 12.6676 7.774 0 11.8606 0 0 0 0 8.18274 O95628 CNOT4_HUMAN CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4) CNOT4 NOT4 Homo sapiens (Human) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of megakaryocyte differentiation [GO:0045652]; ubiquitin-dependent protein catabolic process [GO:0006511] CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842] ALADLTEPIERK 1 2.8 0.66994 0.16825 0 0 0 0 0 4.07818 0 0 0 0 0 0 O95630 STABP_HUMAN STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) STAMBP AMSH Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; hippocampal neuron apoptotic process [GO:0110088]; mitotic cytokinesis [GO:0000281]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell population proliferation [GO:0008284]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] deubiquitinase activity [GO:0101005]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; protein domain specific binding [GO:0019904] AEELKAELLKR;NEFTITHVLIPK 2 5.4 0.93663 -0.52359 0 0 0 0 0 0 0 0 0 15.4423 0 0 O95631 NET1_HUMAN Netrin-1 (Epididymis tissue protein Li 131P) NTN1 NTN1L Homo sapiens (Human) "anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; Cdc42 protein signal transduction [GO:0032488]; cell-cell adhesion [GO:0098609]; chemorepulsion of axon [GO:0061643]; glial cell proliferation [GO:0014009]; inner ear morphogenesis [GO:0042472]; mammary gland duct morphogenesis [GO:0060603]; motor neuron migration [GO:0097475]; negative regulation of axon extension [GO:0030517]; nuclear migration [GO:0007097]; positive regulation of axon extension [GO:0045773]; positive regulation of cell motility [GO:2000147]; positive regulation of glial cell proliferation [GO:0060252]; Ras protein signal transduction [GO:0007265]; regulation of glial cell migration [GO:1903975]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; substrate-dependent cell migration, cell extension [GO:0006930]" actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; cytosol [GO:0005829]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPKIKPLKK;DVRVSSTCGRPPAR;FNMELYKLSGR 3 5.6 0.97859 -2.0982 0 0 0 0 0 9.30383 0 0 0 0 9.10627 0 O95633 FSTL3_HUMAN Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein) FSTL3 FLRG UNQ674/PRO1308 Homo sapiens (Human) cell differentiation [GO:0030154]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090101]; ossification [GO:0001503]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] activin binding [GO:0048185]; fibronectin binding [GO:0001968] HAGSCAGTPEEPPGGESAEEEENFV 1 9.5 0.71309 0.15167 0 0 0 0 0 0 0 0 0 0 5.88618 0 O95639 CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) CPSF4 CPSF30 NAR NEB1 Homo sapiens (Human) mRNA processing [GO:0006397] intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] CGEKGHYANR;DCPWYDRGFCK;KGDQCEFLHEYDMTK 3 13.4 0.97628 -2.2941 0 9.51879 0 0 0 0 0 0 0 0 5.5261 0 O95644 NFAC1_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)" NFATC1 NFAT2 NFATC Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; intracellular signal transduction [GO:0035556]; mononuclear cell differentiation [GO:1903131]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; response to muscle activity [GO:0014850]; skeletal muscle adaptation [GO:0043501]; wound healing [GO:0042060] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasm [GO:0016528]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; FK506 binding [GO:0005528]; mitogen-activated protein kinase p38 binding [GO:0048273]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]" KGETDIGR;SHHRAHYETEGSR 2 2.9 0.92218 -0.44242 0 0 10.8126 0 0 0 0 0 0 0 0 0 O95661 DIRA3_HUMAN GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI) DIRAS3 ARHI NOEY2 RHOI Homo sapiens (Human) genomic imprinting [GO:0071514]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; small GTPase-mediated signal transduction [GO:0007264] plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] IKGNNLHKFPIVLVGNK;LLPALLILRAFKPHR;LRLLPALLILR;RLRLLPALLILR;VVVVGTAGVGK 5 20.1 0.95445 -0.95277 0 12.2953 10.3269 5.85554 10.6006 10.4552 10.6676 5.51169 7.34908 7.16481 0 11.3056 O95670 VATG2_HUMAN V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2) ATP6V1G2 ATP6G ATP6G2 NG38 Homo sapiens (Human) regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; melanosome [GO:0042470]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LKQATRR 1 9 0.97769 -1.516 0 10.5506 0 0 0 0 0 0 0 8.48361 8.31093 0 O95671 ASML_HUMAN Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] ASMTL Homo sapiens (Human) methylation [GO:0032259]; nucleotide metabolic process [GO:0009117] cytosol [GO:0005829] 8-oxo-(d)RTP hydrolase activity [GO:0106379]; dTTP diphosphatase activity [GO:0036218]; nucleoside triphosphate diphosphatase activity [GO:0047429]; O-methyltransferase activity [GO:0008171]; UTP diphosphatase activity [GO:0036221] DPLPSAELYVLCR 1 2.1 0.89714 -0.23443 0 0 0 0 0 0 0 0 0 7.92979 0 0 O95672 ECEL1_HUMAN Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) ECEL1 XCE UNQ2431/PRO4991 Homo sapiens (Human) neuropeptide signaling pathway [GO:0007218]; protein processing [GO:0016485]; respiratory system process [GO:0003016] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] AKVQQLVEDIK;LLARPGGGPGGAAQRK;SGLPRWNR 3 4.5 0.98054 -1.649 0 0 0 0 0 0 0 0 0 0 0 12.125 O95677 EYA4_HUMAN Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) EYA4 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; DNA repair [GO:0006281]; inner ear development [GO:0048839]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; visual perception [GO:0007601] cytoplasm [GO:0005737]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" SSGSKSR 1 1.1 0.90604 -0.27262 0 0 0 0 0 0 0 0 0 0 0 7.67384 O95678 K2C75_HUMAN "Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)" KRT75 K6HF KB18 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198] AQYEDIANR;FASFIDK;FASFIDKVR;FLEQQNK;FLEQQNKVLETK;LEAELRNMQDVVEDFK;LLREYQELMNIK;LVDLEEALQK;NLDLDSIIAEVK;QLESITTER;VRYEDEINK 11 17.8 0.97624 -4.4785 0 0 0 0 9.3812 0 10.3845 11.3912 0 9.84439 0 0 O95684 CEP43_HUMAN Centrosomal protein 43 (FGFR1 oncogene partner) CEP43 FGFR1OP FOP Homo sapiens (Human) cell projection organization [GO:0030030]; microtubule anchoring [GO:0034453]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284] cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292] DLKLISDK;VENKTPLVNESLK 2 5.3 0.95356 -0.78084 0 7.72942 0 0 0 0 0 0 0 9.48091 0 0 O95696 BRD1_HUMAN Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) BRD1 BRL BRPF2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]; response to electrical stimulus [GO:0051602]; response to immobilization stress [GO:0035902] dendrite [GO:0030425]; histone H3-K14 acetyltransferase complex [GO:0036409]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perikaryon [GO:0043204] histone binding [GO:0042393]; histone reader activity [GO:0140566]; metal ion binding [GO:0046872] AVRIAFDRAMNHLSR;HPMDFATMRK;LLDPANR;LTCYLCKQK;MVPLGIDETIDKLK;RSWQWLPK 6 6 0.97567 -3.3185 0 12.0861 7.35085 0 0 10.043 0 0 0 0 0 0 O95707 RPP29_HUMAN Ribonuclease P protein subunit p29 (hPOP4) POP4 RPP29 Homo sapiens (Human) rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682] multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P complex [GO:0030677] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] AFLKRSTPR;AVVLEYFTRHKR;VIPKLNCVFTVETDGFISYIYGSKFQLR 3 22.3 0.77717 0.041712 0 0 6.7237 0 0 0 9.0345 0 0 0 0 7.0247 O95714 HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of Notch signaling pathway [GO:0045746]; neuron differentiation [GO:0030182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] ADLENHNKDGGFWTVIDGK;AFSANGK;ALLSHQDK;DGQVYSWGKGDNQR;DLINTGICESSGKQCLPLVQLIQQLLRNIASQTVAR;DQLGGLKGSK;FKLLSSLPRWR;GGSDGCK;GGSEGCNIPQNIER;ITVQFSDMRTCR;LIDGSEPCWQSSGSQGK;QQALSHILTALQIMYAR;QVLEEKLKYAIHFCK;RCHSSQPGMLLDSWSR;SVVDVCR;TLHSLTQWNGLINKYINSQLR;VIQVACGSR 17 5.1 0.97621 -5.331 11.6302 11.5889 0 6.56189 0 8.1014 0 11.7412 6.21764 9.71881 8.0568 9.67858 O95715 CXL14_HUMAN C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14) CXCL14 MIP2G NJAC SCYB14 PSEC0212 UNQ240/PRO273 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; signal transduction [GO:0007165] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] chemokine activity [GO:0008009] LLAAALLLLLLALYTAR;LLAAALLLLLLALYTARVDGSK 2 19.8 0.81406 -0.0052249 0 0 0 6.84987 0 0 0 0 0 0 0 4.8506 O95718 ERR2_HUMAN Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) ESRRB ERRB2 ESRL2 NR3B2 Homo sapiens (Human) cell dedifferentiation [GO:0043697]; cell population proliferation [GO:0008283]; inner ear development [GO:0048839]; negative regulation of stem cell differentiation [GO:2000737]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" LAGLLELYRAILQLVRR;MSSHDGK;TPGGQGK;VGQEQLR 4 7.5 0.90985 -0.295 0 0 10.2643 0 0 0 0 0 0 13.2352 6.92493 4.5157 O95721 SNP29_HUMAN Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) SNAP29 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] EAISTSKEQEAK 1 4.7 0.88109 -0.16813 0 0 0 0 9.07908 0 0 0 0 0 0 0 O95727 CRTAM_HUMAN Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355) CRTAM Homo sapiens (Human) "adaptive immune response [GO:0002250]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; detection of tumor cell [GO:0002355]; establishment of T cell polarity [GO:0001768]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of activated T cell proliferation [GO:0046007]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of type II interferon production [GO:0032729]; regulation of CD8-positive, alpha-beta T cell activation [GO:2001185]; regulation of T cell activation [GO:0050863]; regulation of T cell differentiation [GO:0045580]" immunological synapse [GO:0001772]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] ENEVSEHTLESYR;SGILLLTLVSFLIFILFIIVQLFIMK;VIVLATPFKPILEASVIR 3 14.5 0.60614 0.17666 0 0 6.99413 0 0 5.58337 0 0 0 0 7.48454 0 O95741 CPNE6_HUMAN Copine-6 (Copine VI) (Neuronal-copine) (N-copine) CPNE6 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; postsynaptic actin cytoskeleton organization [GO:0098974] axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786] QPLQFHVFDAEDGATSPR;VTKPLLLK 2 4.7 0.94447 -0.63292 0 0 0 0 0 0 0 0 0 9.39221 0 0 O95747 OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) OXSR1 KIAA1101 OSR1 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; renal sodium ion absorption [GO:0070294]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] APTISER;DPEKRPTAAELLR;ELNDIRFEFTPGR;LLSGGSVLDIIKHIVAK 4 9.5 0.97266 -2.6774 0 0 0 10.5613 0 0 0 0 0 0 0 10.5182 O95749 GGPPS_HUMAN "Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)" GGPS1 Homo sapiens (Human) farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isoprenoid biosynthetic process [GO:0008299]; isoprenoid metabolic process [GO:0006720] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] dimethylallyltranstransferase activity [GO:0004161]; farnesyltranstransferase activity [GO:0004311]; geranyltranstransferase activity [GO:0004337]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ELEAKAYK;ILLEPYKYLLQLPGKQVR 2 8.7 0.94209 -0.61963 0 0 0 0 0 0 0 0 0 8.38569 0 0 O95750 FGF19_HUMAN Fibroblast growth factor 19 (FGF-19) FGF19 UNQ334/PRO533 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart development [GO:0007507]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] AVALRTVAIKGVHSVR 1 7.4 0.96505 -1.151 0 0 0 0 8.64616 0 0 0 0 0 0 0 O95754 SEM4F_HUMAN Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W) SEMA4F SEMAM SEMAW Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] IDWMVPEAHRQNCR;LESGRGK 2 2.7 0.95146 -0.70352 0 9.51074 0 0 0 0 0 0 0 0 0 3.26631 O95757 HS74L_HUMAN Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) HSPA4L APG1 HSPH3 OSP94 Homo sapiens (Human) protein folding [GO:0006457]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] ALLRLYQECEK;DSSQHTK;FITPEDLSK;MSVVGIDLGFLNCYIAVAR;QDRLNQTLK 5 6.6 0.97671 -2.2781 0 0 0 0 0 8.57126 0 9.39019 12.1862 7.95158 0 0 O95758 PTBP3_HUMAN Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EGQEDQGLTK;NLFIEAGCSVK;TDNLPNQAR;VTNLLMLK 4 6.9 0.94114 -0.61105 0 0 0 0 0 0 0 0 0 11.0595 0 0 O95759 TBCD8_HUMAN TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) TBC1D8 VRP Homo sapiens (Human) blood circulation [GO:0008015]; positive regulation of cell population proliferation [GO:0008284] membrane [GO:0016020] GTPase activator activity [GO:0005096] FEARFNFPEAEKLVTYYSCCCWK;IILPLREVVSIEK;SLPEHPAFQNETGIAALR;VLQGHEDTTK 4 5.6 0.96384 -1.1872 4.94467 0 0 0 0 0 10.0712 0 0 0 0 9.05216 O95760 IL33_HUMAN Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)] IL33 C9orf26 IL1F11 NFHEV Homo sapiens (Human) antibacterial innate immune response [GO:0140367]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; gene expression [GO:0010467]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macrophage proliferation [GO:0120042]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD80 production [GO:0150145]; positive regulation of CD86 production [GO:0150142]; positive regulation of cellular defense response [GO:0010186]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; protein import into nucleus [GO:0006606]; type 2 immune response [GO:0042092] chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transport vesicle [GO:0030133] cytokine activity [GO:0005125]; interleukin-33 receptor binding [GO:0002112] ISTAKWK;LGKSQQKAK;MKPKMKYSTNK 3 10 0.97511 -4.1006 0 0 0 0 0 0 0 0 0 8.30656 0 0 O95777 LSM8_HUMAN U6 snRNA-associated Sm-like protein LSm8 LSM8 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] AEPLNSVAH 1 9.4 0.91727 -0.40747 0 10.1684 0 0 0 0 0 0 0 0 0 0 O95780 ZN682_HUMAN Zinc finger protein 682 ZNF682 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFHWCSPFVR;AFNRCSHLTR;HSHLTKHKTIHTGK;KDGENVGECK;MSSHYTEDLLPEQCMQDSFQK;TFKWFSYLTKHK 6 18.2 0.9762 -5.282 0 0 0 0 11.4237 11.2701 0 0 0 0 11.7223 0 O95782 AP2A1_HUMAN AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) AP2A1 ADTAA CLAPA1 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; endocytosis [GO:0006897]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor-mediated endocytosis [GO:0048260]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843]; synaptic vesicle [GO:0008021] clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877] LINNAIK;QLSLPQQEAQK;TVFEALQAPACHENMVK;WKQLSLPQQEAQKIFK 4 4.1 0.98028 -2.0387 0 0 0 0 0 0 0 0 0 7.78103 0 9.46281 O95785 WIZ_HUMAN Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) WIZ ZNF803 Homo sapiens (Human) positive regulation of nuclear cell cycle DNA replication [GO:0010571]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]" LAFPSTLASTPYSLQLGR;LPGPAPR;RFLHHRGEPR 3 2.1 0.90943 -0.31578 0 11.1802 0 0 0 0 0 0 0 0 0 0 O95786 RIGI_HUMAN Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) RIGI DDX58 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] ALACYTADVR;EGYSGLYEAIESWDFKK;LLCRKCK;MKDALDYLKDFFSNVR;MTTEQRRSLQAFQDYIR;NWIEGNPK;SLQAFQDYIRK;TFVSLLICEHHLKKFPQGQK 8 10.9 0.97776 -2.1656 0 13.5603 13.1587 0 11.3856 4.35811 0 8.26425 8.85109 8.35491 0 0 O95789 ZMYM6_HUMAN Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) ZMYM6 Buster2 KIAA1353 ZNF258 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DFCSQSCLSSYELKK;ETVRFSGVDKPFCSEVCKFLSAR;GAVTKEAAKIIQDESTQEDAMK;KEPLDGECGK;LEEFCCEDCMSK;NCSDEYK;SVSVTQFWINAK;TELFCSINCLSAYRVK;TVTSSGVQVSCHSCK 9 10 0.90661 -0.27288 0 0 0 7.48462 10.6251 0 2.23521 10.3969 0 9.54477 8.80842 0 O95789 ZMYM6_HUMAN Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) ZMYM6 Buster2 KIAA1353 ZNF258 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] SVSVTQFWINAK;YVGRYIKNIAYLFLK 2 4.2 0.85981 -0.081818 0 0 0 0 0 0 0 0 0 8.585 0 0 O95793 STAU1_HUMAN Double-stranded RNA-binding protein Staufen homolog 1 STAU1 STAU Homo sapiens (Human) anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]; protein localization to synapse [GO:0035418] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723] GGAYPPR;LAQIQQAK 2 2.6 0.91151 -0.32117 0 9.17794 0 0 0 0 0 0 0 0 0 0 O95800 GPR75_HUMAN Probable G-protein coupled receptor 75 GPR75 Homo sapiens (Human) chemokine-mediated signaling pathway [GO:0070098]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930] ESMVSPK 1 1.3 0.90846 -0.30929 0 0 0 0 0 0 0 0 0 0 8.70622 0 O95801 TTC4_HUMAN Tetratricopeptide repeat protein 4 (TPR repeat protein 4) TTC4 My044 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; protein folding [GO:0006457] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879] SALNDVTAAR;STLLQVLQHQR 2 5.4 0.93515 -0.51655 0 0 0 0 0 0 0 0 0 0 0 2.91485 O95803 NDST3_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] NDST3 HSST3 UNQ2544/PRO4998 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140] QTCGLFTHTIFYK;YINMDSWNR 2 2.5 0.84666 -0.063802 10.184 0 0 0 0 10.1609 0 0 0 0 6.66789 0 O95810 CAVN2_HUMAN Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) CAVIN2 SDPR Homo sapiens (Human) plasma membrane tubulation [GO:0097320] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein kinase C binding [GO:0005080] GIQNDLTK;VEESRAEK 2 3.8 0.96526 -1.121 0 11.3145 11.1773 0 0 0 0 0 0 0 0 0 O95817 BAG3_HUMAN BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) aggresome assembly [GO:0070842]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; positive regulation of aggrephagy [GO:1905337]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein transport along microtubule [GO:0098840]; spinal cord development [GO:0021510]; striated muscle cell apoptotic process [GO:0010658] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; Z disc [GO:0030018] adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; dynein intermediate chain binding [GO:0045505]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087] AASPFRSSVQGASSR 1 2.6 0.91635 -0.43025 0 0 0 0 0 9.2703 0 0 0 0 0 0 O95819 M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) MAP4K4 HGK KIAA0687 NIK Homo sapiens (Human) intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; neuron projection morphogenesis [GO:0048812]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of hippo signaling [GO:0035332]; positive regulation of keratinocyte migration [GO:0051549]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALFLIPR;QSTVDQKR;RQQLLQEQQLR;SNQTMGWGEK;SSVEVYAWAPKPYHK 5 4 0.95543 -0.85786 0 0 11.4689 9.851 0 5.77913 8.06507 6.94193 0 0 0 9.80777 O95822 DCMC_HUMAN "Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)" MLYCD Homo sapiens (Human) acetyl-CoA biosynthetic process [GO:0006085]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; malonyl-CoA catabolic process [GO:2001294]; positive regulation of fatty acid oxidation [GO:0046321]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glucose metabolic process [GO:0010906]; response to ischemia [GO:0002931]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] identical protein binding [GO:0042802]; malonyl-CoA decarboxylase activity [GO:0050080] FLVQLRADLLEAQALK 1 3.2 0.81188 -0.013097 0 0 0 0 4.37002 0 0 0 0 0 0 0 O95834 EMAL2_HUMAN Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) EML2 EMAP2 EMAPL2 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule polymerization [GO:0031115]; regulation of microtubule nucleation [GO:0010968]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819] microtubule binding [GO:0008017]; tubulin binding [GO:0015631] SSFGAGK 1 1.1 0.60278 0.17818 11.6924 0 0 10.6894 9.10145 0 9.5585 11.0902 10.2805 12.3955 12.508 9.81641 O95835 LATS1_HUMAN Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) LATS1 WARTS Homo sapiens (Human) cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; keratinocyte differentiation [GO:0030216]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein phosphorylation [GO:0006468]; regulation of actin filament polymerization [GO:0030833]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of organ growth [GO:0046620]; regulation of postsynaptic density assembly [GO:0099151]; regulation of protein-containing complex assembly [GO:0043254]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; sister chromatid segregation [GO:0000819] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynapse [GO:0098794]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; nuclear estrogen receptor binding [GO:0030331]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DILAEADNEWVVR;IQSYSPQAFK;SMFVKIKTLGIGAFGEVCLAR;SVTPPPPPR;SYENVDSGDKEK;TLGIGAFGEVCLARK 6 5.8 0.97078 -1.3379 5.10748 11.7539 0 0 10.3181 9.11103 0 0 0 0 0 0 O95837 GNA14_HUMAN Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14) GNA14 Homo sapiens (Human) action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] AGCCCLSAEEK;EVEVDKVSMLSR;FVFAAVK 3 8.5 0.97784 -1.5056 0 0 3.71315 0 0 0 5.76253 0 0 10.6412 0 0 O95838 GLP2R_HUMAN Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R) GLP2R Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell population proliferation [GO:0008284] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glucagon receptor activity [GO:0004967]; peptide hormone binding [GO:0017046] ILKLLISKLK;KIWWIIR;LGSSRAGPGR 3 4.9 0.96632 -1.2629 3.94757 0 0 0 4.27784 0 0 0 0 0 15.0741 0 O95841 ANGL1_HUMAN Angiopoietin-related protein 1 (Angiopoietin-3) (ANG-3) (Angiopoietin-like protein 1) ANGPTL1 ANG3 ANGPT3 ARP1 PSEC0154 UNQ162/PRO188 Homo sapiens (Human) blood coagulation [GO:0007596]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] DPGYPRDLMPPPDLATSPTKSPFK;LEPESEFYR 2 6.7 0.87905 -0.14206 0 0 0 0 8.00084 0 0 0 0 0 9.11699 8.88823 O95843 GUC1C_HUMAN Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C) GUCA1C GCAP3 Homo sapiens (Human) regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]; visual perception [GO:0007601] photoreceptor disc membrane [GO:0097381] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048] DQDLLEIVYK;SIAGDQK 2 8.1 0.95581 -0.9843 0 0 0 0 0 0 0 5.05181 0 0 0 0 O95847 UCP4_HUMAN Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) inner ear development [GO:0048839]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; regulation of D-glucose import [GO:0046324]; response to cold [GO:0009409] apical part of cell [GO:0045177]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; transmembrane transporter activity [GO:0022857] IMNQPRDKQGR;SVPEEEERLLPLTQR 2 8 0.91566 -0.37136 7.8999 0 0 0 0 0 0 0 9.20389 0 0 0 O95848 NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) NUDT14 UGPP Homo sapiens (Human) nucleoside phosphate metabolic process [GO:0006753]; protein N-linked glycosylation via asparagine [GO:0018279]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829] ADP-ribose diphosphatase activity [GO:0047631]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768] EAWEECGYHLAPSDLR 1 7.2 0.78561 0.029414 0 0 0 8.7363 0 0 0 0 0 0 0 0 O95858 TSN15_HUMAN Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15) TSPAN15 NET7 TM4SF15 UNQ677/PRO1311 Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; regulation of membrane protein ectodomain proteolysis [GO:0051043] cell junction [GO:0030054]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197] enzyme binding [GO:0019899] NTTEVVNTMCGYK 1 4.4 0.91458 -0.33669 0 0 0 0 0 0 5.88667 0 0 0 0 0 O95859 TSN12_HUMAN Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12) TSPAN12 NET2 TM4SF12 UNQ774/PRO1568 Homo sapiens (Human) angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; maintenance of blood-brain barrier [GO:0035633]; Norrin signaling pathway [GO:0110135]; regulation of angiogenesis [GO:0045765]; retina layer formation [GO:0010842] membrane [GO:0016020]; plasma membrane [GO:0005886] AREDSVKCLR;MTNYGLPR 2 5.9 0.9812 -1.7879 12.1483 1.49891 0 0 0 0 0 0 0 0 9.84043 0 O95861 BPNT1_HUMAN "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (HsPIP) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)" BPNT1 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytosol [GO:0005829]; mitochondrion [GO:0005739] "3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; metal ion binding [GO:0046872]" EEDLVVWVDPLDGTK;SICSSLAR;VGGAGNK 3 11.9 0.93703 -0.52425 0 8.86734 0 9.41878 0 0 11.1009 0 0 0 0 0 O95863 SNAI1_HUMAN Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) SNAI1 SNAH Homo sapiens (Human) "aortic valve morphogenesis [GO:0003180]; canonical Wnt signaling pathway [GO:0060070]; cartilage morphogenesis [GO:0060536]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle morphogenesis [GO:0031069]; heterochromatin organization [GO:0070828]; left/right pattern formation [GO:0060972]; mesoderm formation [GO:0001707]; negative regulation of cell differentiation involved in embryonic placenta development [GO:0060806]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; Notch signaling pathway [GO:0007219]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; trophoblast giant cell differentiation [GO:0060707]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" HQESGCSGCPR 1 4.2 0.30368 0.2506 0 0 0 0 0 0 10.5531 0 0 0 0 0 O95865 DDAH2_HUMAN "Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein)" DDAH2 DDAH G6A NG30 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; positive regulation of nitric oxide biosynthetic process [GO:0045429] extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] hydrolase activity [GO:0016787] ALQDLGLR;GGGDLPNSQEALQK;TVVAGSSDAAQK 3 11.9 0.9636 -1.0883 0 0 0 0 0 0 0 11.0015 0 0 0 11.3613 O95866 G6B_HUMAN Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b) MPIG6B C6orf25 G6B G6B-B Homo sapiens (Human) blood coagulation [GO:0007596]; erythrocyte differentiation [GO:0030218]; integrin-mediated signaling pathway [GO:0007229]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of signal transduction [GO:0009968]; platelet formation [GO:0030220] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] heparin binding [GO:0008201] LSTADPADASTIYAVVV 1 7.1 0.8464 -0.061025 0 12.3631 0 0 0 0 0 0 0 0 0 0 O95872 GPAN1_HUMAN G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5) GPANK1 ANKRD59 BAT4 G5 GPATCH10 Homo sapiens (Human) nucleic acid binding [GO:0003676] APAAEAVAEGASGRHGQGRSLEAEDK 1 7.3 0.87381 -0.10544 0 0 0 0 0 5.39324 0 0 0 0 0 0 O95876 FRITZ_HUMAN WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) WDPCP BBS15 C2orf86 FRITZ Homo sapiens (Human) auditory receptor cell morphogenesis [GO:0002093]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; circulatory system development [GO:0072359]; digestive system development [GO:0055123]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; establishment of protein localization [GO:0045184]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; podocyte cell migration [GO:0090521]; regulation of cilium assembly [GO:1902017]; regulation of embryonic cell shape [GO:0016476]; regulation of establishment of cell polarity [GO:2000114]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization [GO:0032880]; regulation of ruffle assembly [GO:1900027]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; septin cytoskeleton organization [GO:0032185]; smoothened signaling pathway [GO:0007224]; tongue morphogenesis [GO:0043587] axonemal basal plate [GO:0097541]; axoneme [GO:0005930]; cilium [GO:0005929]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] LILGCEDSSLILYETHRR 1 2.4 0.26832 0.26119 0 0 0 8.82184 0 0 0 14.6719 0 0 0 0 O95886 DLGP3_HUMAN Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3) DLGAP3 DAP3 Homo sapiens (Human) modification of postsynaptic structure [GO:0099010]; modulation of chemical synaptic transmission [GO:0050804]; signaling [GO:0023052] cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090] EFHSIGVQVEEDKR;ERSLDSVDRQR;RSSSVDQAR;SLDSVDR;VPPPIPK 5 4.2 0.96395 -1.1824 0 0 0 9.85089 7.22949 0 0 0 10.4967 0 8.28434 0 O95897 NOE2_HUMAN Noelin-2 (Olfactomedin-2) OLFM2 NOE2 Homo sapiens (Human) positive regulation of smooth muscle cell differentiation [GO:0051152]; protein secretion [GO:0009306]; regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905174]; signal transduction [GO:0007165] AMPA glutamate receptor complex [GO:0032281]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] LDPHTLEVMRSWDTGYPKR;TLGDFIK 2 5.7 0.87528 -0.12049 0 0 9.10518 0 0 0 0 0 0 0 0 9.12391 O95905 ECD_HUMAN Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) ECD Homo sapiens (Human) fibroblast proliferation [GO:0048144]; mRNA processing [GO:0006397]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase binding [GO:0035035] FAPMLVPYIWQNQPFNLKYKPGK;IMTSVTFTK;LVAAAVQAFYLRDPIDLR 3 7.8 0.95181 -0.68458 0 9.04819 0 8.90914 0 0 0 0 0 0 0 0 O95907 MOT3_HUMAN Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) SLC16A8 MCT3 Homo sapiens (Human) lactate transport [GO:0015727] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] AGDAPGEAEADGAGLQLR;AVSVFFR;GAGGPRR;GEPTEPEIEARPR 4 8.9 0.93282 -0.49517 0 9.75358 9.43271 0 0 0 0 0 0 0 6.15344 8.6824 O95922 TTLL1_HUMAN Polyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1) TTLL1 C22orf7 Homo sapiens (Human) cerebellar Purkinje cell differentiation [GO:0021702]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; microtubule cytoskeleton organization [GO:0000226]; mucociliary clearance [GO:0120197]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222]; sperm axoneme assembly [GO:0007288] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" GIFLINKLSQIKK;KFDLRLYVLVSTYRPLR;LSDDQIVNHFPNHYELTRK 3 11.6 0.25644 0.27371 0 9.73824 0 0 0 0 9.981 10.3311 0 0 0 8.47078 O95926 SYF2_HUMAN Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) SYF2 CBPIN GCIPIP Homo sapiens (Human) "embryonic organ development [GO:0048568]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell population proliferation [GO:0008284]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] RNA binding [GO:0003723] FYGKYTAEIK;MVIDLEKQIEKR;QIKPDMETYER 3 13.6 0.97822 -1.9426 0 0 12.7401 0 0 0 0 0 0 0 8.03386 0 O95931 CBX7_HUMAN Chromobox protein homolog 7 CBX7 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] AGAPELVDK;FPPRGPNLESHSHRR 2 9.6 0.98056 -1.7246 0 0 0 0 0 0 0 0 0 0 0 12.2776 O95932 TGM3L_HUMAN Protein-glutamine gamma-glutamyltransferase 6 (EC 2.3.2.13) (Transglutaminase Y) (TGY) (TGase Y) (Transglutaminase-3-like) (TGase-3-like) (Transglutaminase-6) (TG6) (TGase-6) TGM6 TGM3L Homo sapiens (Human) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] AVGSDSR;LFGVEASGRR 2 2.4 0.95219 -0.72085 0 11.2513 0 0 0 0 0 0 0 0 0 0 O95935 TBX18_HUMAN T-box transcription factor TBX18 (T-box protein 18) TBX18 Homo sapiens (Human) cell fate specification [GO:0001708]; cochlea morphogenesis [GO:0090103]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate anterior/posterior regionalization [GO:0021999]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of SA node cell action potential [GO:0098907]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node cell fate commitment [GO:0060930]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; ureter development [GO:0072189] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GGGAGEK;RGSPCSMLSLK 2 3 0.94427 -0.63119 0 0 0 0 0 0 0 0 0 0 7.69579 0 O95947 TBX6_HUMAN T-box transcription factor TBX6 (T-box protein 6) TBX6 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; heart looping [GO:0001947]; mesoderm development [GO:0007498]; mesodermal cell fate specification [GO:0007501]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; somite rostral/caudal axis specification [GO:0032525]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" IAANPFAKGFR;RWEPSGKAEPR 2 7.5 0.97441 -1.4227 0 0 8.99777 0 0 0 0 0 0 0 0 0 O95948 ONEC2_HUMAN One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) ONECUT2 HNF6B Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell fate commitment [GO:0045165]; cilium assembly [GO:0060271]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; mesenchymal stem cell migration [GO:1905319]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peripheral nervous system neuron development [GO:0048935]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; transforming growth factor beta receptor signaling pathway [GO:0007179] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MKAAYTAYRCLTK;MWKWLQEPEFQR;YSIPQAIFAQRVLCR 3 7.9 0.97832 -1.9298 0 0 0 10.3504 0 0 9.29653 0 0 0 9.15282 0 O95965 ITGBL_HUMAN Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein) ITGBL1 OSCP TIED Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; integrin-mediated signaling pathway [GO:0007229] cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178] AGWHGDKCEFQCDITPWESKR;CYCGNCYCK;CYCGNCYCKAGWHGDK;FCECDDRECIDDETEEICGGHGK;LSRAESERR;TCECDDR;YSDDFCSGHGQCNCGR;YSDDFCSGHGQCNCGRCDCK 8 18 0.95448 -0.96018 0 5.81534 6.11241 4.80679 0 4.04998 10.056 9.2241 5.15583 0 9.01491 5.22114 O95967 FBLN4_HUMAN EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1) EFEMP2 FBLN4 UNQ200/PRO226 Homo sapiens (Human) aorta development [GO:0035904]; aorta smooth muscle tissue morphogenesis [GO:0060414]; elastic fiber assembly [GO:0048251]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of smooth muscle cell-matrix adhesion [GO:1905609]; regulation of collagen fibril organization [GO:1904026]; vascular associated smooth muscle cell development [GO:0097084] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803] CQCEPGFQLGPNNR;DGFSCSDIDECSYSSYLCQYR;SCVDVNECDMGAPCEQRCFNSYGTFLCR 3 14.2 0.91041 -0.28211 6.75328 0 0 0 0 0 11.0566 0 0 0 6.72996 0 O95969 SG1D2_HUMAN Secretoglobin family 1D member 2 (Lipophilin-B) SCGB1D2 LIPHB LPNB Homo sapiens (Human) extracellular space [GO:0005615] SLIAEVLVKILKK 1 14.4 0.87181 -0.095661 0 0 0 0 0 0 0 0 0 0 5.64328 0 O95970 LGI1_HUMAN Leucine-rich glioma-inactivated protein 1 (Epitempin-1) LGI1 EPT UNQ775/PRO1569 Homo sapiens (Human) axon guidance [GO:0007411]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cell growth [GO:0030307]; positive regulation of synaptic transmission [GO:0050806] axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] DFDCIITEFAK;GLDSLTNVDLR 2 3.9 0.84811 -0.077236 0 0 11.0114 0 0 0 0 0 7.08023 0 0 0 O95971 BY55_HUMAN "CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]" CD160 BY55 Homo sapiens (Human) "adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; mucosal immune response [GO:0002385]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of angiogenesis [GO:0016525]; negative regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900280]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immune response to tumor cell [GO:0002857]; positive regulation of type II interferon production [GO:0032729]; T cell costimulation [GO:0031295]" extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] activating MHC class I receptor activity [GO:0032397]; kinase binding [GO:0019900]; MHC class I protein complex binding [GO:0023024]; MHC class I receptor activity [GO:0032393]; MHC class Ib receptor activity [GO:0032394]; signaling receptor binding [GO:0005102] KEEAEGFVVFLCK;SQKSGIR 2 11 0.96524 -1.162 0 0 0 0 0 8.83365 0 0 0 7.66661 0 0 O95980 RECK_HUMAN Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) RECK ST15 Homo sapiens (Human) blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of metalloendopeptidase activity [GO:1904684]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of angiogenesis [GO:0045765]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of establishment of blood-brain barrier [GO:0090210]; regulation of extracellular matrix organization [GO:1903053]; sprouting angiogenesis [GO:0002040] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; Wnt signalosome [GO:1990909] coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; Wnt-protein binding [GO:0017147] AEDHACQNACKR;ANTSTCR;SCIVGGK;VTNKKPITVLEILQKIR 4 4.4 0.48384 0.19016 0 6.90725 9.24543 0 0 0 7.30952 6.9397 0 8.86406 0 0 O95985 TOP3B_HUMAN DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) TOP3B TOP3B1 Homo sapiens (Human) chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA topological change [GO:0006265] condensed chromosome [GO:0000793]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA binding [GO:0003723]; RNA topoisomerase activity [GO:0140226]" IQSFKPETYWVLQAK;WKVACNK 2 2.6 0.97925 -1.8791 0 0 0 11.2171 0 0 0 0 0 0 0 0 O95990 F107A_HUMAN Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A) FAM107A DRR1 TU3A Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to nutrient levels [GO:0031669]; cognition [GO:0050890]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of long-term synaptic potentiation [GO:1900272]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein stability [GO:0031647] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; stress fiber [GO:0001725]; synapse [GO:0045202] actin binding [GO:0003779] IATLTSEEREL;LQCPFEQELLRRQQR 2 18.1 0.97463 -2.3938 0 0 0 0 0 0 0 0 9.81713 0 0 0 O95994 AGR2_HUMAN Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) AGR2 AG2 UNQ515/PRO1030 Homo sapiens (Human) digestive tract morphogenesis [GO:0048546]; inflammatory response [GO:0006954]; lung goblet cell differentiation [GO:0060480]; mucus secretion [GO:0070254]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of developmental growth [GO:0048639]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of gene expression [GO:0010628]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; positive regulation of protein localization to plasma membrane [GO:1903078] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615] dystroglycan binding [GO:0002162]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802] DTKDSRPK;IMFVDPSLTVR;IPVSAFLLLVALSYTLARDTTVKPGAKK;LPQTLSR;LYAYEPADTALLLDNMKK 5 41.1 0 3.5662 14.051 12.6443 13.7465 11.1616 11.7884 10.9549 7.65378 7.77709 8.19081 8.91707 0 9.64688 O95995 DRC4_HUMAN Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8) GAS8 DRC4 GAS11 Homo sapiens (Human) axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; regulation of microtubule binding [GO:1904526] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] AHNDLLRTYEAK;EERNYFQLER 2 4.6 0.98024 -2.0076 0 0 0 10.1367 0 0 0 0 0 6.85075 0 0 O95996 APCL_HUMAN Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like) APC2 APCL Homo sapiens (Human) activation of GTPase activity [GO:0090630]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055] actin filament [GO:0005884]; beta-catenin destruction complex [GO:0030877]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; lamellipodium membrane [GO:0031258]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017] DPGPGGGR;EVLKHLQGKLEQEAR;LDELPHVETQFSMQMDLIR;NLSWRADINSK;RPPVSGLR;SVLSALWNLSAHSTENK;VASALSSGSESSDR;YAGMTLTNLTFGDVANK 8 4.7 0.95246 -0.67926 0 6.85699 9.73057 10.1017 8.86746 8.44315 0 10.0027 10.1013 5.5044 7.71781 9.59753 O95997 PTTG1_HUMAN Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) PTTG1 EAP1 PTTG TUTR1 Homo sapiens (Human) cell division [GO:0051301]; chromosome organization [GO:0051276]; DNA repair [GO:0006281]; homologous chromosome segregation [GO:0045143]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular function activator activity [GO:0140677]; SH3 domain binding [GO:0017124] SSVPASDDAYPEIEK 1 7.4 0.78358 0.026501 0 0 0 0 0 0 0 5.97753 0 0 0 0 O95998 I18BP_HUMAN Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa) IL18BP Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] interleukin-18 binding [GO:0042007]; receptor antagonist activity [GO:0048019] ATPVSQTTTAATASVR 1 8.2 0.78117 0.033143 0 0 0 0 0 0 0 0 9.52229 0 0 0 O96000 NDUBA_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) NDUFB10 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] VPDITECK 1 4.7 0.91364 -0.39033 0 0 0 0 0 0 9.47072 0 0 0 0 0 O96002 CX001_HUMAN Putative transmembrane protein CXorf1 CXorf1 Homo sapiens (Human) membrane [GO:0016020] TYEHQHSKMVPAYR 1 12.6 0.92086 -0.44586 0 0 0 8.06215 0 0 0 0 0 0 0 0 O96004 HAND1_HUMAN "Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND)" HAND1 BHLHA27 EHAND Homo sapiens (Human) angiogenesis [GO:0001525]; blastocyst development [GO:0001824]; cardiac left ventricle formation [GO:0003218]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cartilage morphogenesis [GO:0060536]; embryonic heart tube development [GO:0035050]; embryonic heart tube formation [GO:0003144]; heart development [GO:0007507]; heart looping [GO:0001947]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]; trophoblast giant cell differentiation [GO:0060707]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]" LEALGGR 1 3.3 0.90828 -0.30952 0 0 0 0 0 0 0 0 0 0 9.53304 0 O96005 CLPT1_HUMAN Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) CLPTM1 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of T cell differentiation in thymus [GO:0033081] endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886] GABA receptor binding [GO:0050811] AAAQEADGAR;GSVPPPLDQYVK;ITKVMDVRLDR;STYIESSTK;VAGIFPR 5 7.3 0.72274 0.131 0 0 4.08542 0 0 0 0 7.66171 0 7.70722 6.37452 0 O96006 ZBED1_HUMAN E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog) ZBED1 ALTE DREF hDREF KIAA0785 TRAMP Homo sapiens (Human) negative regulation by host of viral genome replication [GO:0044828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autosumoylation [GO:1990466]; protein sumoylation [GO:0016925]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]" VLGLNEDPLKWWSDR 1 2.2 0.91477 -0.43428 0 0 0 9.01717 0 0 0 0 0 0 0 0 O96008 TOM40_HUMAN Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) TOMM40 C19orf1 PEREC1 TOM40 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; TOM complex [GO:0140596] porin activity [GO:0015288]; protein transmembrane transporter activity [GO:0008320] MAIQTQQSK 1 2.5 0.25452 0.27567 0 9.0237 0 0 0 0 0 0 0 0 0 0 O96009 NAPSA_HUMAN Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02) NAPSA NAP1 NAPA Homo sapiens (Human) membrane protein proteolysis [GO:0033619]; proteolysis [GO:0006508]; surfactant homeostasis [GO:0043129] alveolar lamellar body [GO:0097208]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233] EPAELPK 1 1.7 0.91015 -0.31172 0 0 0 0 0 0 0 0 0 0 0 7.42777 O96011 PX11B_HUMAN Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta) PEX11B Homo sapiens (Human) peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] ALYFACDNVLWAGK;DAWVRFSAQSQAR;LQVLLLARVLRGHPPLLLDVVR 3 18.9 0.91736 -0.42519 0 0 0 0 0 6.35852 0 5.31683 0 0 0 0 O96013 PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) PAK4 KIAA1142 Homo sapiens (Human) apoptotic process [GO:0006915]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of angiogenesis [GO:0045766]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding involved in cell-cell adhesion [GO:0098641]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGPEKRPKSSR;LLVRDPAQR;NLHKVSPSLK 3 5.1 0.97607 -4.5257 0 0 0 0 0 9.27633 0 0 0 0 14.0113 0 O96014 WNT11_HUMAN Protein Wnt-11 WNT11 Homo sapiens (Human) "adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; atrial septum development [GO:0003283]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; intracellular signal transduction [GO:0035556]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesenchymal cell proliferation [GO:0010463]; mesonephric duct development [GO:0072177]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of stem cell proliferation [GO:2000647]; neuroendocrine cell differentiation [GO:0061101]; neuron differentiation [GO:0030182]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of transforming growth factor beta2 production [GO:0032915]; primary heart field specification [GO:0003138]; response to nutrient levels [GO:0031667]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; somite development [GO:0061053]; stem cell proliferation [GO:0072089]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein kinase activator activity [GO:0030295] DSELVYLQSSPDFCMKNEK;TSNGSDSCDLMCCGR 2 9.6 0.93332 -0.49653 0 0 12.2846 0 0 0 0 0 0 0 0 12.9512 O96017 CHK2_HUMAN Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) CHEK2 CDS1 CHK2 RAD53 Homo sapiens (Human) "cell division [GO:0051301]; cellular response to bisphenol A [GO:1903926]; cellular response to gamma radiation [GO:0071480]; cellular response to stress [GO:0033554]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of anoikis [GO:2000210]; positive regulation of DNA-templated transcription [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of autophagosome assembly [GO:2000785]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; response to glycoside [GO:1903416]; signal transduction in response to DNA damage [GO:0042770]; thymocyte apoptotic process [GO:0070242]" cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625] CVNDNYWFGRDKSCEYCFDEPLLK;FAIGSAR;GVRHHPRPVCSLK;IFREVGPK;ITDFGHSK;RKFAIGSAR;TCKKVAIK 7 11.9 0.97674 -4.7876 0 0 0 9.45397 9.18165 0 0 0 0 0 4.90651 10.3122 O96019 ACL6A_HUMAN Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) ACTL6A BAF53 BAF53A INO80K Homo sapiens (Human) blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; telomere maintenance [GO:0000723] brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; Ino80 complex [GO:0031011]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713] TAVLTAFANGR 1 2.6 0.9352 -0.52925 0 0 0 0 0 0 0 0 0 0 9.43948 0 O96024 B3GT4_HUMAN "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3GALT4 GALT4 Homo sapiens (Human) ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "ganglioside galactosyltransferase activity [GO:0047915]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" LAGATHYPLDR 1 2.9 0.80156 0.014407 0 0 0 0 0 0 0 0 0 0 0 8.97977 O96028 NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) NSD2 KIAA1090 MMSET TRX5 WHSC1 Homo sapiens (Human) atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] IKHAHENDITHFYMLTIDKDR;IKLLKPISGKLR;NLSDACKPLK;QYHVQFFGDAPERAWIFEK;SQWSLLSEKQR;VFKNALQEAEARFR 6 6.4 0.97585 -2.3079 8.55838 2.79365 0 5.93076 9.74094 10.8906 0 10.2883 7.42282 0 4.4361 0 O96028 NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) NSD2 KIAA1090 MMSET TRX5 WHSC1 Homo sapiens (Human) atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] IKHAHENDITHFYMLTIDKDR;MAGSFCWRMLGLVSK;MLGLVSK;VFKNALQEAEARFR 4 7 0.9293 -0.48134 0 0 0 0 0 0 0 0 10.4536 0 8.63267 0 O96028 NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) NSD2 KIAA1090 MMSET TRX5 WHSC1 Homo sapiens (Human) atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] SKKFEHLK 1 2.9 0.86993 -0.095167 0 0 0 8.23074 0 0 0 0 0 0 0 0 P00156 CYB_HUMAN Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) MT-CYB COB CYTB MTCYB Homo sapiens (Human) "animal organ regeneration [GO:0031100]; cellular respiration [GO:0045333]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to cadmium ion [GO:0046686]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to copper ion [GO:0046688]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mercury ion [GO:0046689]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121] DVNYGWIIR;LGGVLALLLSILILAMIPILHMSK 2 8.7 0.90753 -0.30327 0 0 0 0 0 0 0 4.64022 0 0 8.24308 0 P00325 ADH1B_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta) ADH1B ADH2 Homo sapiens (Human) retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; zinc ion binding [GO:0008270] INEGFDLLHSGK 1 3.2 0.93759 -0.5604 0 0 0 0 0 0 0 0 8.84878 0 0 0 P00326 ADH1G_HUMAN Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma) ADH1C ADH3 Homo sapiens (Human) retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; zinc ion binding [GO:0008270] GAIFGGFKSK 1 2.7 0.98057 -1.5971 0 0 0 0 0 10.8582 0 0 0 0 0 0 P00338 LDHA_HUMAN L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) LDHA PIG19 Homo sapiens (Human) glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; L-lactate dehydrogenase activity [GO:0004459] ATLKDQLIYNLLK;ATLKDQLIYNLLKEEQTPQNK;DLADELALVDVIEDK;DQLIYNLLK;DYNVTANSK;FIIPNVVK;GEMMDLQHGSLFLR;IVSGKDYNVTANSK;KSADTLWGIQK;LVIITAGAR;QVVESAYEVIK;SADTLWGIQK;SADTLWGIQKELQF;TLHPDLGTDK;VHPVSTMIK;VIGSGCNLDSAR;VTLTSEEEAR 17 44.6 0 164.33 15.7698 14.5444 14.5514 11.263 12.3103 11.9109 16.0666 15.7929 15.801 15.6116 15.7438 14.0785 P00338 LDHA_HUMAN L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) LDHA PIG19 Homo sapiens (Human) glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; L-lactate dehydrogenase activity [GO:0004459] ATLKDQLIYNLLK;ATLKDQLIYNLLKEEQTPQNK;DLADELALVDVIEDK;DQLIYNLLK;DYNVTANSK;EQWKECRYTLGDPK;FIIPNVVK;GEMMDLQHGSLFLR;IVSGKDYNVTANSK;LVIITAGAR;TLHPDLGTDK;VIGSGCNLDSAR 12 42.7 0.57122 0.18203 0 0 0 0 0 0 0 0 0 0 9.47881 0 P00352 AL1A1_HUMAN "Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)" ALDH1A1 ALDC ALDH1 PUMB1 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; cellular detoxification of aldehyde [GO:0110095]; fructosamine catabolic process [GO:0030392]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; maintenance of lens transparency [GO:0036438]; negative regulation of cold-induced thermogenesis [GO:0120163]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; synapse [GO:0045202] 3-deoxyglucosone dehydrogenase activity [GO:0106373]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase (NAD+) activity [GO:0019145]; androgen binding [GO:0005497]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; GTPase activator activity [GO:0005096]; NAD binding [GO:0051287]; retinal dehydrogenase activity [GO:0001758] ANNTFYGLSAGVFTK;ELGEYGFHEYTEVK;IFINNEWHDSVSGK;IFVEESIYDEFVRRSVER;MSSSGTPDLPVLLTDLK;QAFQIGSPWR;TIPIDGNFFTYTR;VTLELGGK 8 21.8 0 11.631 0 0 0 10.9374 0 6.90953 10.3897 11.483 10.615 0 0 13.3294 P00367 DHE3_HUMAN "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" GLUD1 GLUD Homo sapiens (Human) glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; L-leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803] ALASLMTYK;DDGSWEVIEGYR;FTMELAK;GASIVEDKLVEDLR;HGGTIPIVPTAEFQDR;IIAEGANGPTTPEADKIFLER;LVEDLRTR;NYTDNELEK;TAAYVNAIEK;VYNEAGVTFT;YNLGLDLR;YSTDVSVDEVK 12 23.1 0 3.5435 11.1113 12.6722 11.7267 10.2016 11.4231 9.49504 0 0 0 0 8.48083 0 P00374 DYR_HUMAN Dihydrofolate reductase (EC 1.5.1.3) DHFR Homo sapiens (Human) axon regeneration [GO:0031103]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; negative regulation of translation [GO:0017148]; one-carbon metabolic process [GO:0006730]; positive regulation of nitric-oxide synthase activity [GO:0051000]; regulation of removal of superoxide radicals [GO:2000121]; response to methotrexate [GO:0031427]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653] cytosol [GO:0005829]; mitochondrion [GO:0005739] dihydrofolate reductase activity [GO:0004146]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; sequence-specific mRNA binding [GO:1990825] LLPEYPGVLSDVQEEKGIKYK 1 11.2 0.76537 0.066865 0 0 0 8.62132 0 0 0 0 0 0 0 0 P00387 NB5R3_HUMAN NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) CYB5R3 DIA1 Homo sapiens (Human) blood circulation [GO:0008015]; cholesterol biosynthetic process [GO:0006695]; nitric oxide biosynthetic process [GO:0006809] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; hemoglobin complex [GO:0005833]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958] "ADP binding [GO:0043531]; AMP binding [GO:0016208]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; NAD binding [GO:0051287]" STPAITLESPDIKYPLR 1 5.6 0.91552 -0.4326 0 11.5924 0 0 0 7.97378 11.1752 0 0 0 0 0 P00390 GSHR_HUMAN "Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)" GSR GLUR GRD1 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADPH) activity [GO:0004362]; NADP binding [GO:0050661] ALLTPVAIAAGR;TLSGLEVSMVTAVPGR 2 5.4 0.1 0.3692 11.3492 0 0 9.48246 0 0 11.418 11.5031 11.3136 10.5776 10.4883 12.0539 P00403 COX2_HUMAN Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II) MT-CO2 COII COX2 COXII MTCO2 Homo sapiens (Human) "ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333]; lactation [GO:0007595]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; response to hypoxia [GO:0001666]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] IFEMGPVFTL;TDAIPGR 2 7.5 0 3.0826 10.7407 10.3367 10.1943 0 0 0 0 0 0 0 0 0 P00439 PH4H_HUMAN Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) PAH Homo sapiens (Human) amino acid biosynthetic process [GO:0008652]; catecholamine biosynthetic process [GO:0042423]; L-phenylalanine catabolic process [GO:0006559]; tyrosine biosynthetic process [GO:0006571] cytosol [GO:0005829] iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505] EEVGALAKVLRLFEENDVNLTHIESRPSR;HDIGATVHELSRDKK;SLPALTNIIKILR 3 12.6 0.95216 -0.7096 0 0 0 0 0 0 0 0 0 7.06415 10.1669 0 P00441 SODC_HUMAN Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) SOD1 Homo sapiens (Human) action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270] GDGPVQGIINFEQK;HVGDLGNVTADK;TLVVHEK 3 21.4 0 3.091 0 0 0 0 0 0 0 0 11.3876 9.85842 11.4774 0 P00450 CERU_HUMAN Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) CP Homo sapiens (Human) intracellular copper ion homeostasis [GO:0006878]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] "copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; glutathione peroxidase activity [GO:0004602]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on metal ions, oxygen as acceptor [GO:0016724]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; protein-folding chaperone binding [GO:0051087]" AGLQAFFQVQECNKSSSK;DNEDFQESNR 2 2.6 0.96533 -1.1373 0 0 0 0 9.57909 0 0 0 0 0 0 0 P00451 FA8_HUMAN "Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]" F8 F8C Homo sapiens (Human) "acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] AEVEDNIMVTFR;EVGSLGTSATNSVTYKK;LPLEETELEK;NNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIR;YYSSFVNMER 5 3.5 0.97783 -1.9516 0 10.8602 0 8.79581 9.81407 0 2.24053 0 0 9.09851 0 0 P00480 OTC_HUMAN "Ornithine transcarbamylase, mitochondrial (OTCase) (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)" OTC Homo sapiens (Human) ammonium homeostasis [GO:0097272]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240]; L-arginine biosynthetic process [GO:0006526]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; ornithine catabolic process [GO:0006593]; response to biotin [GO:0070781]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; ornithine carbamoyltransferase activity [GO:0004585]; phosphate ion binding [GO:0042301]; phospholipid binding [GO:0005543] SLGMIFEK;SLVFPEAENR 2 5.1 0.9548 -0.88385 0 0 3.31274 8.77218 0 0 0 0 10.0839 0 0 0 P00488 F13A_HUMAN Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) F13A1 F13A Homo sapiens (Human) "blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; peptide cross-linking [GO:0018149]" blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; transferase complex [GO:1990234] metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] DFKLSITFRNNSHNR 1 2 0.8513 -0.074091 0 11.8003 0 0 0 0 0 0 0 0 0 0 P00491 PNPH_HUMAN Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyinosine catabolic process [GO:0006149]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731] LGADAVGMSTVPEVIVAR;STVPGHAGR;VIMDYESLEK 3 12.8 0.88119 -0.16849 0 0 0 0 0 0 0 0 0 10.4548 8.97828 0 P00492 HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HPRT1 HPRT Homo sapiens (Human) adenine metabolic process [GO:0046083]; AMP salvage [GO:0044209]; central nervous system neuron development [GO:0021954]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; dopamine metabolic process [GO:0042417]; dopaminergic neuron differentiation [GO:0071542]; GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; locomotory behavior [GO:0007626]; lymphocyte proliferation [GO:0046651]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166]; response to amphetamine [GO:0001975]; striatum development [GO:0021756]; T cell mediated cytotoxicity [GO:0001913] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] SIPMTVDFIR;VFIPHGLIMDRTER;VIGGDDLSTLTGK 3 17 0.96438 -1.116 0 0 10.1288 0 0 0 0 10.3444 0 3.98559 0 10.9733 P00505 AATM_HUMAN "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" GOT2 KYAT4 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; fatty acid transport [GO:0015908]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; malate-aspartate shuttle [GO:0043490]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723] ASAELALGENSEVLK;DAGMQLQGYR;FVTVQTISGTGALR;IGASFLQR;KAEAQIAAK;NMGLYGER;QWLQEVK 7 16.5 0 27.297 12.306 11.404 11.6316 9.05365 0 9.66237 12.1688 12.3336 11.9031 10.8005 11.0828 0 P00519 ABL1_HUMAN Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) ABL1 ABL JTK7 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; activated T cell proliferation [GO:0050798]; activation of protein kinase C activity [GO:1990051]; alpha-beta T cell differentiation [GO:0046632]; associative learning [GO:0008306]; autophagy [GO:0006914]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; canonical NF-kappaB signal transduction [GO:0007249]; cardiac muscle cell proliferation [GO:0060038]; cell-cell adhesion [GO:0098609]; cellular response to dopamine [GO:1903351]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; cerebellum morphogenesis [GO:0021587]; DN4 thymocyte differentiation [GO:1904157]; DNA conformation change [GO:0071103]; DNA damage response [GO:0006974]; endothelial cell migration [GO:0043542]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microspike assembly [GO:0030035]; mismatch repair [GO:0006298]; mitochondrial depolarization [GO:0051882]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cellular senescence [GO:2000773]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; neural tube closure [GO:0001843]; neuroepithelial cell differentiation [GO:0060563]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuropilin signaling pathway [GO:0038189]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; podocyte apoptotic process [GO:1903210]; positive regulation of actin filament binding [GO:1904531]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendrite development [GO:1900006]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of microtubule binding [GO:1904528]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vasoconstriction [GO:0045907]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic microtubule plus-end [GO:1904518]; protein modification process [GO:0036211]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagy [GO:0010506]; regulation of axon extension [GO:0030516]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of DNA-templated transcription [GO:0006355]; regulation of endocytosis [GO:0030100]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of microtubule polymerization [GO:0031113]; regulation of modification of synaptic structure [GO:1905244]; regulation of postsynaptic specialization assembly [GO:0099150]; regulation of T cell differentiation [GO:0045580]; response to endoplasmic reticulum stress [GO:0034976]; response to epinephrine [GO:0071871]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction in response to DNA damage [GO:0042770]; spleen development [GO:0048536]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; transitional one stage B cell differentiation [GO:0002333]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ruffle [GO:0001726] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; bubble DNA binding [GO:0000405]; delta-catenin binding [GO:0070097]; DNA binding [GO:0003677]; ephrin receptor binding [GO:0046875]; four-way junction DNA binding [GO:0000400]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; mitogen-activated protein kinase binding [GO:0051019]; neuropilin binding [GO:0038191]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activity [GO:0004713]; sequence-specific double-stranded DNA binding [GO:1990837]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; syntaxin binding [GO:0019905]; transcription coactivator activity [GO:0003713] AGENRSDQVTR;EDTMEVEEFLKEAAVMK;ESGGSGFR;FAFREAINK;GAVSTLLQAPELPTKTR;GPAEESR;HSWYHGPVSR;SEKPALPR;SEKPALPRK;WEMERTDITMK 10 8.8 0.97394 -3.045 10.7061 5.63282 0 0 0 0 11.2238 9.42905 8.68391 0 0 6.36272 P00533 EGFR_HUMAN Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) EGFR ERBB ERBB1 HER1 Homo sapiens (Human) "astrocyte activation [GO:0048143]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex cell migration [GO:0021795]; circadian rhythm [GO:0007623]; digestive tract morphogenesis [GO:0048546]; diterpenoid metabolic process [GO:0016101]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hydrogen peroxide metabolic process [GO:0042743]; learning or memory [GO:0007611]; liver regeneration [GO:0097421]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; neuron projection morphogenesis [GO:0048812]; ossification [GO:0001503]; ovulation cycle [GO:0042698]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mucus secretion [GO:0070257]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vasoconstriction [GO:0045907]; protein insertion into membrane [GO:0051205]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to hydroxyisoflavone [GO:0033594]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; tongue development [GO:0043586]; translation [GO:0006412]; vasodilation [GO:0042311]" "apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435]; synaptic membrane [GO:0097060]" actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; macrophage colony-stimulating factor receptor activity [GO:0005011]; MAP kinase kinase kinase activity [GO:0004709]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; ubiquitin protein ligase binding [GO:0031625]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] CDPSCPNGSCWGAGEENCQK;ELIIEFSKMARDPQR;ESDCLVCRKFR;GLWIPEGEK;LFGTSGQK;LLGAEEK;VLGSGAFGTVYK 7 6.8 0.9753 -4.1068 5.99596 0 0 0 7.92196 10.3315 9.38027 0 0 0 0 10.7223 P00533 EGFR_HUMAN Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) EGFR ERBB ERBB1 HER1 Homo sapiens (Human) "astrocyte activation [GO:0048143]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex cell migration [GO:0021795]; circadian rhythm [GO:0007623]; digestive tract morphogenesis [GO:0048546]; diterpenoid metabolic process [GO:0016101]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hydrogen peroxide metabolic process [GO:0042743]; learning or memory [GO:0007611]; liver regeneration [GO:0097421]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; neuron projection morphogenesis [GO:0048812]; ossification [GO:0001503]; ovulation cycle [GO:0042698]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mucus secretion [GO:0070257]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vasoconstriction [GO:0045907]; protein insertion into membrane [GO:0051205]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to hydroxyisoflavone [GO:0033594]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; tongue development [GO:0043586]; translation [GO:0006412]; vasodilation [GO:0042311]" "apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435]; synaptic membrane [GO:0097060]" actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; macrophage colony-stimulating factor receptor activity [GO:0005011]; MAP kinase kinase kinase activity [GO:0004709]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; ubiquitin protein ligase binding [GO:0031625]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] AMLFCLFK;CDPSCPNGSCWGAGEENCQK;ESDCLVCRKFR;LFGTSGQK 4 6.7 0.91329 -0.39033 0 0 0 0 0 0 0 0 0 0 10.3645 0 P00540 MOS_HUMAN Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) MOS Homo sapiens (Human) chromatin organization [GO:0006325]; establishment of meiotic spindle orientation [GO:0051296]; MAPK cascade [GO:0000165]; meiotic spindle organization [GO:0000212]; negative regulation of metaphase/anaphase transition of meiotic cell cycle [GO:1902103]; oocyte maturation [GO:0001556]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; regulation of meiotic nuclear division [GO:0040020]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GEGVTPK;LLLGATLPR;LLLGATLPRAPRLPR;RLAWCSIDWEQVCLLQR 4 11.3 0.044405 0.50366 7.44104 9.86093 0 0 0 10.0004 7.13965 6.58793 9.00256 11.121 5.58075 5.74717 P00558 PGK1_HUMAN Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) PGK1 PGKA MIG10 OK/SW-cl.110 Homo sapiens (Human) canonical glycolysis [GO:0061621]; cellular response to hypoxia [GO:0071456]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0160218]; negative regulation of angiogenesis [GO:0016525]; plasminogen activation [GO:0031639] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial matrix [GO:0005759] ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; protein serine/threonine kinase activity [GO:0004674]; protein-disulfide reductase (NAD(P)H) activity [GO:0047134] AEKNGVK;AEPAKIEAFR;AGGFLMK;AHSSMVGVNLPQK;ALESPERPFLAILGGAK;ALMDEVVK;ELNYFAK;FCLDNGAK;ITLPVDFVTADKFDENAK;LGDVYVNDAFGTAHR;LTLDKLDVK;NNQITNNQR;SLSNKLTLDKLDVK;VDFNVPMK;VLNNMEIGTSLFDEEGAK;VLPGVDALSNI;YAEAVTR;YSLEPVAVELK 18 45.1 0 87.934 15.8021 15.9434 15.2142 12.664 11.6711 12.1958 15.0317 15.6646 15.9745 15.2064 14.5265 14.3103 P00568 KAD1_HUMAN Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) AK1 Homo sapiens (Human) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; outer dense fiber [GO:0001520] (deoxy)adenylate kinase activity [GO:0047506]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] ATEPVIAFYEK;EVQQGEEFER;GFLIDGYPR;GTQCEKIVQKYGYTHLSTGDLLR;IIFVVGGPGSGK;LETYYKATEPVIAFYEK 6 36.6 0.78569 0.018232 0 7.81333 0 5.58222 8.31093 0 11.5671 0 11.5897 8.19145 9.49015 0 P00709 LALBA_HUMAN Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7) LALBA LYZL7 Homo sapiens (Human) apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; lactose biosynthetic process [GO:0005989]; signal transduction [GO:0007165] extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; lactose synthase activity [GO:0004461]; lysozyme activity [GO:0003796] LEQWLCEK;RFFVPLFLVGILFPAILAK 2 19 0.87955 -0.14519 0 0 0 0 0 9.92521 0 0 0 0 0 0 P00734 THRB_HUMAN Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Homo sapiens (Human) acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]; thrombin-activated receptor signaling pathway [GO:0070493] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053] ISMLEKIYIHPRYNWR;YTACETAR 2 3.9 0.93012 -0.4687 0 10.582 0 0 0 0 0 0 0 0 0 0 P00736 C1R_HUMAN Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain] C1R Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] SYPPDLRCNYSIR;YTTEIIKCPQPKTLDEFTIIQNLQPQYQFR 2 6.1 0.90967 -0.27934 0 0 0 0 0 0 8.77873 0 0 9.05452 0 0 P00739 HPTR_HUMAN Haptoglobin-related protein HPR Homo sapiens (Human) blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; spherical high-density lipoprotein particle [GO:0034366] hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252] YQCKNYYR 1 2.3 0.95163 -0.69495 0 0 0 0 0 8.83772 0 0 0 0 0 0 P00740 FA9_HUMAN Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain] F9 Homo sapiens (Human) blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] ATCLRSTKFTIYNNMFCAGFHEGGR;SALVLQYLRVPLVDR 2 8.7 0.97612 -1.4514 2.71629 0 0 0 0 0 0 0 0 1.73552 7.94052 0 P00747 PLMN_HUMAN "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Homo sapiens (Human) biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; tissue remodeling [GO:0048771] blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102] ELRPWCFTTDPNK;ELRPWCFTTDPNKR;EVVLLLLLFLK 3 3.1 0.8734 -0.11158 0 0 0 0 3.07267 0 11.7324 0 3.66698 9.14647 0 0 P00748 FA12_HUMAN Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)] F12 Homo sapiens (Human) "blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; plasma kallikrein-kinin cascade [GO:0002353]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibrinolysis [GO:0051919]; positive regulation of plasminogen activation [GO:0010756]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; response to misfolded protein [GO:0051788]; zymogen activation [GO:0031638]" collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] calcium ion binding [GO:0005509]; misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252] RLTLQGIISWGSGCGDR 1 2.8 0.57906 0.18005 0 0 0 0 0 0 0 0 10.8623 0 0 0 P00749 UROK_HUMAN Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] PLAU Homo sapiens (Human) blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; plasminogen activation [GO:0031639]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of signaling receptor activity [GO:0010469]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell-matrix adhesion [GO:2000097]; regulation of wound healing [GO:0061041]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; urokinase plasminogen activator signaling pathway [GO:0038195] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine protease inhibitor complex [GO:0097180]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] serine-type endopeptidase activity [GO:0004252] TLRPRFK 1 1.6 0.90328 -0.26449 0 0 10.6891 0 0 0 0 0 0 0 0 0 P00750 TPA_HUMAN Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT Homo sapiens (Human) "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]" apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180] phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] SYQVICRDEK;VTNYLDWIR 2 3.4 0.96621 -1.1293 0 0 0 9.54554 0 0 0 0 0 0 0 0 P00750 TPA_HUMAN Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT Homo sapiens (Human) "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]" apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180] phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] SVSSPATASMRPCPLSIRSG;SYQVICRDEK 2 10.3 0.9167 -0.43484 0 0 0 0 0 0 0 0 0 5.50077 0 0 P00750 TPA_HUMAN Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT Homo sapiens (Human) "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]" apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180] phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] SYQGCSEPR;VTNYLDWIR 2 3.5 0.90908 -0.31605 0 0 0 0 0 0 9.16085 8.85453 9.92622 0 0 0 P00750 TPA_HUMAN Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT Homo sapiens (Human) "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]" apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180] phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] AQCSEGNSDCYFGNGSAYR;VTNYLDWIR 2 7.1 0.78376 0.020853 0 0 0 0 0 0 0 0 0 0 6.13354 0 P00751 CFAB_HUMAN Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment] CFB BF BFD Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] complement binding [GO:0001848]; serine-type endopeptidase activity [GO:0004252] DISEVVTPR;KVGSQYR 2 2.1 0.96751 -1.3217 0 0 0 0 0 0 0 0 0 0 10.8616 0 P00846 ATP6_HUMAN ATP synthase subunit a (F-ATPase protein 6) MT-ATP6 ATP6 ATPASE6 MTATP6 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hyperoxia [GO:0055093] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] LTSKQMMTMHNTK 1 5.8 0.92196 -0.44674 0 0 0 0 0 0 5.80134 0 0 0 0 0 P00918 CAH2_HUMAN Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) CA2 Homo sapiens (Human) "angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; morphogenesis of an epithelium [GO:0002009]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic anion transport [GO:0044070]; secretion [GO:0046903]" apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886] arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; zinc ion binding [GO:0008270] KYAAELHLVHWNTK 1 5.4 0.58882 0.17866 0 0 0 0 0 0 0 0 0 0 9.66356 0 P00966 ASSY_HUMAN Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ASS1 ASS Homo sapiens (Human) acute-phase response [GO:0006953]; argininosuccinate metabolic process [GO:0000053]; aspartate metabolic process [GO:0006531]; cellular response to amine stimulus [GO:0071418]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oleic acid [GO:0071400]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; circadian rhythm [GO:0007623]; citrulline metabolic process [GO:0000052]; diaphragm development [GO:0060539]; kidney development [GO:0001822]; L-arginine biosynthetic process [GO:0006526]; liver development [GO:0001889]; midgut development [GO:0007494]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to mycotoxin [GO:0010046]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050] cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204] amino acid binding [GO:0016597]; argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643] APNTPDILEIEFKK;IDIVENR;MPEFYNR;NDLMEYAK;NQAPPGLYTK;QVEIAQR;VFIEDVSR;YVSHGATGK 8 17 0.0024876 1.6794 0 0 0 0 0 0 8.72537 9.66991 0 10.6342 10.095 0 P00973 OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) OAS1 OIAS Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cellular respiration [GO:1901857]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; surfactant homeostasis [GO:0043129]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] GEFIQEIR;QLEACQRER;YYDFKNPIIEK 3 7 0.97467 -2.3854 0 0 0 0 0 0 7.97361 0 10.2489 0 0 0 P01008 ANT3_HUMAN Antithrombin-III (ATIII) (Serpin C1) SERPINC1 AT3 PRO0309 Homo sapiens (Human) blood coagulation [GO:0007596]; regulation of blood coagulation [GO:0030193] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] IEDGFSLKEQLQDMGLVDLFSPEK;LPGIVAEGR 2 7.1 0.95129 -0.70505 0 0 0 0 0 12.2108 11.8129 12.1061 0 0 0 12.8532 P01009 A1AT_HUMAN Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] SERPINA1 AAT PI PRO0684 PRO2209 Homo sapiens (Human) acute-phase response [GO:0006953]; blood coagulation [GO:0007596] collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093] identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] LVDKFLEDVK;VVNPTQK 2 4.1 0.9811 -1.7992 0 0 0 0 0 0 0 9.62401 0 0 0 0 P01011 AACT_HUMAN Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less] SERPINA3 AACT GIG24 GIG25 Homo sapiens (Human) acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; maintenance of gastrointestinal epithelium [GO:0030277]; regulation of lipid metabolic process [GO:0019216] azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; serine-type endopeptidase inhibitor activity [GO:0004867] DLDSQTMMVLVNYIFFK 1 4 0.78349 0.025756 0 0 0 0 0 0 8.79918 0 0 0 0 0 P01019 ANGT_HUMAN Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] AGT SERPINA8 Homo sapiens (Human) angiotensin-activated signaling pathway [GO:0038166]; blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; nitric oxide-cGMP-mediated signaling [GO:0038060]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of blood volume by renin-angiotensin [GO:0002016]; regulation of cardiac conduction [GO:1903779]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of extracellular matrix assembly [GO:1901201]; regulation of renal output by angiotensin [GO:0002019]; regulation of renal sodium excretion [GO:0035813]; regulation of vasoconstriction [GO:0019229]; renal system process [GO:0003014]; renin-angiotensin regulation of aldosterone production [GO:0002018]; response to angiotensin [GO:1990776]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; vasoconstriction [GO:0042310] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; serine-type endopeptidase inhibitor activity [GO:0004867]; type 1 angiotensin receptor binding [GO:0031702]; type 2 angiotensin receptor binding [GO:0031703] ATILCLLAWAGLAAGDR;VEGLTFQQNSLNWMK 2 6.7 0.93796 -0.56929 0 0 0 0 9.51682 9.34725 0 0 0 0 0 0 P01023 A2MG_HUMAN Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) A2M CPAMD5 FWP007 Homo sapiens (Human) "acute inflammatory response to antigenic stimulus [GO:0002438]; acute-phase response [GO:0006953]; embryonic liver development [GO:1990402]; luteinization [GO:0001553]; negative regulation of complement activation, lectin pathway [GO:0001869]; response to carbon dioxide [GO:0010037]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to prostaglandin E [GO:0034695]; stem cell differentiation [GO:0048863]" blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] brain-derived neurotrophic factor binding [GO:0048403]; calcium-dependent protein binding [GO:0048306]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; interleukin-8 binding [GO:0019959]; nerve growth factor binding [GO:0048406]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; tumor necrosis factor binding [GO:0043120] ATVLNYLPK;GEAFTLK;GPTQEFK;LPPNVVEESAR;MVSGFIPLKPTVK;QTVSWAVTPK 6 3.9 0 14.027 13.314 11.5936 12.923 11.369 9.61624 12.6008 11.2447 0 11.3818 13.3233 13.4862 11.2994 P01024 CO3_HUMAN Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] C3 CPAMD1 Homo sapiens (Human) "amyloid-beta clearance [GO:0097242]; B cell activation [GO:0042113]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]; vertebrate eye-specific patterning [GO:0150064]" azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] EALKLEEK;GYTQQLAFR;ITHRIHWESASLLRSEETK;KQELSEAEQATR;KVFLDCCNYITELRR;SEKGRNK;TIYTPGSTVLYR;TLDPERLGR;VLLDGVQNPR 9 6.1 0.97457 -3.5241 0 11.9421 0 10.4061 0 0 9.34729 11.7875 0 0 0 11.9011 P01031 CO5_HUMAN Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] C5 CPAMD4 Homo sapiens (Human) "cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of chemokine production [GO:0032722]; positive regulation of vascular endothelial growth factor production [GO:0010575]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579] chemokine activity [GO:0008009]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102] CCYDGACVNNDETCEQR;IPLDLVPKTEIKR;ISLGPRCIK;LHMKTLLPVSKPEIRSYFPESWLWEVHLVPR;LQGTLPVEAR;LSMDIDVSYK;VSITSITVENVFVKYK 7 6.3 0.97305 -2.6176 0 0 0 0 0 7.87234 0 0 10.308 11.2877 5.70578 0 P01037 CYTN_HUMAN Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1) CST1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982] cysteine-type endopeptidase inhibitor activity [GO:0004869] ATKDDYYR;DDYYRRPLRVLR 2 10.6 0.9158 -0.43121 0 0 3.71765 0 2.90789 0 0 0 7.49977 0 8.85957 0 P01106 MYC_HUMAN Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) MYC BHLHE39 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to hypoxia [GO:0071456]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular iron ion homeostasis [GO:0006879]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex disassembly [GO:0032986]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to growth factor [GO:0070848]; response to xenobiotic stimulus [GO:0009410]; rRNA metabolic process [GO:0016072] chromatin [GO:0000785]; cytoplasm [GO:0005737]; Myc-Max complex [GO:0071943]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571] "core promoter sequence-specific DNA binding [GO:0001046]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SCF ubiquitin ligase complex binding [GO:1905761]; transcription coregulator binding [GO:0001221]; transcription regulator activator activity [GO:0140537]" ATAYILSVQAEEQK;LISEEDLLR 2 5.1 0.95483 -0.94766 0 0 0 10.9138 10.8117 10.6116 0 0 11.6509 0 0 11.6385 P01116 RASK_HUMAN "GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]" KRAS KRAS2 RASK2 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain astrocyte development [GO:0021897]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; homeostasis of number of cells within a tissue [GO:0048873]; MAPK cascade [GO:0000165]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, GABAergic [GO:0032228]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; type I pneumocyte differentiation [GO:0060509]; visual learning [GO:0008542]" cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495] QAQDLAR;SYGIPFIETSAKTR 2 11.1 0.95547 -0.79141 0 0 0 0 0 8.85256 0 0 0 0 0 0 P01127 PDGFB_HUMAN Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin) PDGFB PDGF2 SIS Homo sapiens (Human) angiogenesis [GO:0001525]; cell chemotaxis [GO:0060326]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mycophenolic acid [GO:0071506]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; embryonic placenta development [GO:0001892]; gene expression [GO:0010467]; heart development [GO:0007507]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; metanephric glomerular mesangial cell development [GO:0072255]; monocyte chemotaxis [GO:0002548]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; paracrine signaling [GO:0038001]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric mesenchymal cell migration [GO:2000591]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905176]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; response to wounding [GO:0009611] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265] chemoattractant activity [GO:0042056]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; superoxide-generating NADPH oxidase activator activity [GO:0016176] ATVTLEDHLACK;CSGCCNNR;IEIVRKKPIFK 3 12.9 0.98069 -1.6194 0 4.84459 0 0 0 0 0 0 0 8.15679 0 0 P01130 LDLR_HUMAN Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; artery morphogenesis [GO:0048844]; cellular response to fatty acid [GO:0071398]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; high-density lipoprotein particle clearance [GO:0034384]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; long-term memory [GO:0007616]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of gene expression [GO:0010629]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of receptor recycling [GO:0001920]; phagocytosis [GO:0006909]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cholesterol metabolic process [GO:0090181]; regulation of phosphatidylcholine catabolic process [GO:0010899]; regulation of protein metabolic process [GO:0051246]; response to caloric restriction [GO:0061771] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362]; lysosome [GO:0005764]; membrane [GO:0016020]; PCSK9-LDLR complex [GO:1990666]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; somatodendritic compartment [GO:0036477]; sorting endosome [GO:0097443] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; clathrin heavy chain binding [GO:0032050]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; very-low-density lipoprotein particle receptor activity [GO:0030229]; virus receptor activity [GO:0001618] AVGSIAYLFFTNR;IGYECLCPDGFQLVAQRR;WVCDGSAECQDGSDESQETCSPK 3 6.6 0.89205 -0.2135 0 0 0 8.08311 0 6.94603 0 10.9835 0 0 0 0 P01133 EGF_HUMAN Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)] EGF Homo sapiens (Human) angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cerebellar granule cell precursor proliferation [GO:0021930]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; ERK1 and ERK2 cascade [GO:0070371]; mammary gland alveolus development [GO:0060749]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of secretion [GO:0051048]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of receptor internalization [GO:0002092]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of calcium ion import [GO:0090279]; regulation of protein localization to cell surface [GO:2000008]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; guanyl-nucleotide exchange factor activity [GO:0005085]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] IYWVDLER;LLTLIILLPVVSK;NPYEESSR;QSVIEMANLDGSK 4 3.5 0.98134 -1.7637 0 0 0 0 0 0 0 0 0 0 5.94753 10.9393 P01137 TGFB1_HUMAN Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] TGFB1 TGFB Homo sapiens (Human) adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460]; aortic valve morphogenesis [GO:0003180]; ATP biosynthetic process [GO:0006754]; branch elongation involved in mammary gland duct branching [GO:0060751]; bronchiole development [GO:0060435]; canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; cellular response to acetaldehyde [GO:1905641]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to ionizing radiation [GO:0071479]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; chondrocyte differentiation [GO:0002062]; columnar/cuboidal epithelial cell maturation [GO:0002069]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; defense response to fungus [GO:0050832]; digestive tract development [GO:0048565]; embryonic liver development [GO:1990402]; endoderm development [GO:0007492]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; gene expression [GO:0010467]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heart valve morphogenesis [GO:0003179]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; inner ear development [GO:0048839]; intracellular calcium ion homeostasis [GO:0006874]; Langerhans cell differentiation [GO:0061520]; lens fiber cell differentiation [GO:0070306]; liver regeneration [GO:0097421]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; macrophage derived foam cell differentiation [GO:0010742]; mammary gland branching involved in thelarche [GO:0060744]; membrane protein intracellular domain proteolysis [GO:0031293]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; myofibroblast differentiation [GO:0036446]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of ossification [GO:0030279]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; osteoclast differentiation [GO:0030316]; phosphate-containing compound metabolic process [GO:0006796]; phospholipid homeostasis [GO:0055091]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of odontogenesis [GO:0042482]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasculature development [GO:1904018]; protein export from nucleus [GO:0006611]; receptor catabolic process [GO:0032801]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of blood vessel remodeling [GO:0060312]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cartilage development [GO:0061035]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of enamel mineralization [GO:0070173]; regulation of interleukin-23 production [GO:0032667]; regulation of protein import into nucleus [GO:0042306]; regulation of sodium ion transport [GO:0002028]; regulation of striated muscle tissue development [GO:0016202]; regulatory T cell differentiation [GO:0045066]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to vitamin D [GO:0033280]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; retina vasculature development in camera-type eye [GO:0061298]; salivary gland morphogenesis [GO:0007435]; sprouting angiogenesis [GO:0002040]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tolerance induction to self antigen [GO:0002513]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] axon [GO:0030424]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] cytokine activity [GO:0005125]; deubiquitinase activator activity [GO:0035800]; enzyme binding [GO:0019899]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] NCCVRQLYIDFR;VLMVETHNEIYDK 2 6.4 0.91609 -0.43042 0 7.08162 0 0 0 0 0 13.6133 0 0 0 0 P01138 NGF_HUMAN Beta-nerve growth factor (Beta-NGF) NGF NGFB Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of Ras protein signal transduction [GO:0046579] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; synaptic vesicle [GO:0008021] growth factor activity [GO:0008083]; lipid binding [GO:0008289]; metalloendopeptidase inhibitor activity [GO:0008191]; nerve growth factor receptor binding [GO:0005163] ALTMDGK;RARSAPAAAIAAR;SKRSSSHPIFHR 3 13.3 0.98005 -1.8665 0 0 0 0 0 0 0 0 0 10.8417 0 8.23012 P01189 COLI_HUMAN Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] POMC Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; cellular pigmentation [GO:0033059]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; negative regulation of tumor necrosis factor production [GO:0032720]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of oxytocin production [GO:0140668]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of appetite [GO:0032098]; regulation of blood pressure [GO:0008217]; regulation of corticosterone secretion [GO:2000852]; regulation of glycogen metabolic process [GO:0070873]; response to melanocyte-stimulating hormone [GO:1990680]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; secretory granule lumen [GO:0034774] G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782] RNSSSSGSSGAGQKR 1 5.6 0.85636 -0.080906 0 8.58692 0 0 0 0 0 0 0 0 0 0 P01210 PENK_HUMAN Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe] PENK Homo sapiens (Human) "aggressive behavior [GO:0002118]; behavioral fear response [GO:0001662]; cellular response to cAMP [GO:0071320]; cellular response to oxidative stress [GO:0034599]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; cellular response to vitamin D [GO:0071305]; chemical synaptic transmission [GO:0007268]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; general adaptation syndrome, behavioral process [GO:0051867]; glial cell proliferation [GO:0014009]; locomotory exploration behavior [GO:0035641]; neuropeptide signaling pathway [GO:0007218]; osteoblast differentiation [GO:0001649]; positive regulation of behavioral fear response [GO:2000987]; response to calcium ion [GO:0051592]; response to epinephrine [GO:0071871]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; startle response [GO:0001964]; synaptic signaling via neuropeptide [GO:0099538]; transmission of nerve impulse [GO:0019226]" axon terminus [GO:0043679]; cell body fiber [GO:0070852]; chromaffin granule lumen [GO:0034466]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; neuronal dense core vesicle lumen [GO:0099013]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; synaptic vesicle lumen [GO:0034592] neuropeptide hormone activity [GO:0005184]; opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628] AECSQDCATCSYR;RYGGFMRR 2 7.9 0.97828 -2.0777 0 0 0 0 0 0 0 0 0 0 0 11.2939 P01215 GLHA_HUMAN Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Lutropin alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha) (Thyrotropin alpha chain) CGA Homo sapiens (Human) follicle-stimulating hormone secretion [GO:0046884]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone secretion [GO:0032275]; negative regulation of organ growth [GO:0046621]; organ growth [GO:0035265]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of signaling receptor activity [GO:0010469]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590] extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696] follicle-stimulating hormone activity [GO:0016913]; hormone activity [GO:0005179] SKKTMLVQK 1 7.8 0.82475 -0.021326 0 0 0 0 0 0 0 0 0 7.61102 0 0 P01225 FSHB_HUMAN Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain) FSHB Homo sapiens (Human) female gamete generation [GO:0007292]; female pregnancy [GO:0007565]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone biosynthetic process [GO:0006701]; regulation of osteoclast differentiation [GO:0045670]; regulation of signaling receptor activity [GO:0010469]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914] follicle-stimulating hormone activity [GO:0016913] DLVYKDPARPK 1 8.5 0.88514 -0.18104 0 0 0 0 0 0 9.47962 0 0 0 0 0 P01229 LSHB_HUMAN Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) LHB Homo sapiens (Human) cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; progesterone biosynthetic process [GO:0006701]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; pituitary gonadotropin complex [GO:0061696] hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] EGCPVCITVNTTICAGYCPTMMR 1 16.3 0.70047 0.16126 0 0 0 0 0 0 0 0 0 0 0 4.39349 P01236 PRL_HUMAN Prolactin (PRL) PRL Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; lactation [GO:0007595]; mammary gland development [GO:0030879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of lactation [GO:1903489]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; prolactin signaling pathway [GO:0038161]; response to nutrient levels [GO:0031667] endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; prolactin receptor binding [GO:0005148] IDNYLKLLK 1 4 0.97284 -1.3709 11.2893 11.143 0 0 0 0 0 0 0 0 0 0 P01241 SOMA_HUMAN Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) GH1 Homo sapiens (Human) animal organ development [GO:0048513]; bone maturation [GO:0070977]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667] endosome lumen [GO:0031904]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; growth hormone activity [GO:0070186]; growth hormone receptor binding [GO:0005131]; hormone activity [GO:0005179]; metal ion binding [GO:0046872]; prolactin receptor binding [GO:0005148] ISLLLIQSWLEPVQFLR;IVQCRSVEGSCGF;LFDNAMLR 3 17.5 0.9543 -0.95515 0 0 0 5.94085 5.60893 0 10.4031 0 0 0 0 0 P01266 THYG_HUMAN Thyroglobulin (Tg) TG Homo sapiens (Human) hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; identical protein binding [GO:0042802] AFCVDGEGRR;CEVERFTATSFGHPYVPSCRR;CPTDCEK;ELPGSRVRGGQPR;FLAVQSVISGRFR;GFGGDPR;GGFIPGSLTAR;RFQAPEPLNWTGSWDASKPR;SGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEK;SQAIQVGTSWK;TSADGAK 11 5.5 0.97722 -1.5236 10.6699 11.4647 14.1234 0 9.83742 0 11.5534 8.2328 11.1273 15.2913 16.0464 11.6468 P01350 GAST_HUMAN Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)] GAST GAS Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; response to food [GO:0032094]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179] QLGPQGPPHLVADPSKK 1 16.8 0.71373 0.14953 0 0 0 0 0 0 0 12.5519 0 0 0 0 P01567 IFNA7_HUMAN Interferon alpha-7 (IFN-alpha-7) (Interferon alpha-J) (LeIF J) (Interferon alpha-J1) (IFN-alpha-J1) IFNA7 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132] ISPFSCLKDRHEFR 1 7.4 0.95896 -1.0342 0 0 0 0 0 0 0 11.1206 0 0 0 0 P01569 IFNA5_HUMAN Interferon alpha-5 (IFN-alpha-5) (Interferon alpha-61) (Interferon alpha-G) (LeIF G) IFNA5 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] TLMIMAQMGR 1 5.3 0.89696 -0.2347 0 0 0 0 0 0 0 11.5164 0 0 0 0 P01570 IFN14_HUMAN Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H) IFNA14 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] TLMLMAQMRR 1 5.3 0.73521 0.11106 0 0 0 0 0 0 0 8.55148 0 0 0 0 P01574 IFNB_HUMAN Interferon beta (IFN-beta) (Fibroblast interferon) IFNB1 IFB IFNB Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of Lewy body formation [GO:0140123]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral genome replication [GO:0045071]; neuron cellular homeostasis [GO:0070050]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of MHC class I biosynthetic process [GO:0045343]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] chloramphenicol O-acetyltransferase activity [GO:0008811]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] SSNFQCQKLLWQLNGRLEYCLK;VEILRNFYFINRLTGYLR 2 21.4 0.74582 0.096863 0 0 7.15097 0 0 0 0 0 0 0 0 7.656 P01579 IFNG_HUMAN Interferon gamma (IFN-gamma) (Immune interferon) IFNG Homo sapiens (Human) "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; humoral immune response [GO:0006959]; macrophage activation involved in immune response [GO:0002281]; macrophage differentiation [GO:0030225]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular respiration [GO:1901857]; positive regulation of chemokine production [GO:0032722]; positive regulation of core promoter binding [GO:1904798]; positive regulation of cytokine production [GO:0001819]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550]; positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of iron ion import across plasma membrane [GO:1904440]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vitamin D biosynthetic process [GO:0060557]; regulation of insulin secretion [GO:0050796]; regulation of metabolic process [GO:0019222]; response to virus [GO:0009615]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]" extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; type II interferon receptor binding [GO:0005133] KYFNAGHSDVADNGTLFLGILK 1 13.3 0.87005 -0.096499 0 0 0 0 0 0 0 0 10.3119 0 0 0 P01602 KV105_HUMAN Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue) IGKV1-5 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] ASSLESGVPSR 1 9.4 0.94101 -0.58311 0 0 8.30419 0 0 0 0 0 0 0 0 0 P01718 LV327_HUMAN Immunoglobulin lambda variable 3-27 (Ig lambda chain V-IV region Kern) IGLV3-27 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] ITCSGDVLAKK 1 9.7 0.82524 -0.020176 0 0 0 0 0 0 0 0 0 12.5399 12.6764 0 P01730 CD4_HUMAN T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4) CD4 Homo sapiens (Human) adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; defense response to Gram-negative bacterium [GO:0050829]; enzyme-linked receptor protein signaling pathway [GO:0007167]; helper T cell enhancement of adaptive immune response [GO:0035397]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; macrophage differentiation [GO:0030225]; maintenance of protein location in cell [GO:0032507]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of viral entry into host cell [GO:0046598]; regulation of calcium ion transport [GO:0051924]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell selection [GO:0045058] clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; interleukin-16 binding [GO:0042011]; interleukin-16 receptor activity [GO:0042012]; lipid binding [GO:0008289]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] ILGNQGSFLTK;SIQFHWKNSNQIK 2 5.2 0.95543 -0.82989 0 0 12.0353 0 0 11.6866 0 0 0 0 0 0 P01732 CD8A_HUMAN T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) CD8A MAL Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cytotoxic T cell differentiation [GO:0045065]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101] coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; protein kinase binding [GO:0019901] APPLAPELRAK 1 4 0.93284 -0.51284 0 0 10.7176 0 0 0 11.4891 0 0 0 0 0 P01737 TVA84_HUMAN T cell receptor alpha variable 8-4 (T cell receptor alpha chain V region PY14) TRAV8-4 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605] GINGFEAEFKK;LLLLVPVLEVIFTLGGTR 2 25.7 0.1728 0.34356 11.5703 0 0 0 0 0 9.96005 0 9.40342 0 0 9.45469 P01743 HV146_HUMAN Immunoglobulin heavy variable 1-46 (Ig heavy chain V-I region DOT) (Ig heavy chain V-I region HG3) (Ig heavy chain V-I region Mot) IGHV1-46 Homo sapiens (Human) immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] KPGASVK 1 6 0.8157 -0.003139 0 0 0 0 7.78901 0 0 0 0 0 0 0 P01833 PIGR_HUMAN Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] PIGR Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc receptor signaling pathway [GO:0038093]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; receptor clustering [GO:0043113]; signal transduction [GO:0007165] azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory IgA immunoglobulin complex [GO:0071751] polymeric immunoglobulin binding [GO:0001790]; polymeric immunoglobulin receptor activity [GO:0001792] ADAAPDEK;ALVSTLVPLGLVLAVGAVAVGVARAR;DAGFYWCLTNGDTLWR;DVSLAKADAAPDEK 4 7.3 0.97433 -1.4228 0 0 0 10.7159 0 6.03122 0 0 10.5669 0 7.25974 0 P01854 IGHE_HUMAN Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND) IGHE Homo sapiens (Human) "adaptive immune memory response [GO:0090716]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell antigen processing and presentation [GO:0002450]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; eosinophil degranulation [GO:0043308]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; macrophage differentiation [GO:0030225]; mast cell degranulation [GO:0043303]; primary adaptive immune response [GO:0090720]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]" "extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgE B cell receptor complex [GO:0071744]; IgE immunoglobulin complex [GO:0071742]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]" antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987] ASGKPVNHSTRK 1 2.2 0.93388 -0.50447 0 0 0 0 0 10.2536 0 0 0 0 0 0 P01857 IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE) IGHG1 Homo sapiens (Human) "adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; complement-dependent cytotoxicity [GO:0097278]" "blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]" antigen binding [GO:0003823]; Fc-gamma receptor I complex binding [GO:0034988]; immunoglobulin receptor binding [GO:0034987] VKWIFSSVVDLK;WQQGNVFSCSVMHEALHNHYTQK 2 8.8 0.95137 -0.69378 0 0 0 0 0 0 0 0 0 0 0 5.34883 P01871 IGHM_HUMAN Immunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region BOT) (Ig mu chain C region GAL) (Ig mu chain C region OU) IGHM Homo sapiens (Human) "adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; pre-B cell allelic exclusion [GO:0002331]" "blood microparticle [GO:0072562]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hexameric IgM immunoglobulin complex [GO:0071757]; IgM B cell receptor complex [GO:0071755]; IgM immunoglobulin complex [GO:0071753]; immunoglobulin complex, circulating [GO:0042571]; pentameric IgM immunoglobulin complex [GO:0071756]; plasma membrane [GO:0005886]" antigen binding [GO:0003823] VQHPNGNK;VTERTVDK 2 3.4 0.96523 -1.1613 9.39191 0 0 0 0 0 0 0 0 0 0 0 P01893 HLAH_HUMAN "Putative HLA class I histocompatibility antigen, alpha chain H (HLA-12.4) (HLA-AR) (MHC class I antigen H)" HLA-H HLAH Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] APWMEREGPKYWDR;ETLQRADPPK;TLLLLLSGALALTQTWAR;WAAVVVPSGEEQR 4 15.2 0.87609 -0.13184 0 0 0 0 0 0 0 9.32073 0 10.2834 10.7958 14.3657 P02008 HBAZ_HUMAN Hemoglobin subunit zeta (HBAZ) (Hemoglobin zeta chain) (Zeta-globin) HBZ HBZ2 Homo sapiens (Human) carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] extracellular exosome [GO:0070062]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] MSLTKTERTIIVSMWAK;SLTKTER;VDPVNFK 3 16.9 0.96479 -1.2261 0 8.55432 0 0 0 0 0 0 0 0 10.4329 0 P02042 HBD_HUMAN Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) HBD Homo sapiens (Human) carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] LHVDPENFR;LLVVYPWTQR;TAVNALWGK 3 19 0.0045558 1.2332 0 10.1548 0 9.27268 9.51302 9.0453 0 0 6.80555 9.11382 9.10462 0 P02452 CO1A1_HUMAN Collagen alpha-1(I) chain (Alpha-1 type I collagen) COL1A1 Homo sapiens (Human) blood vessel development [GO:0001568]; bone trabecula formation [GO:0060346]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to amino acid stimulus [GO:0071230]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to fluoride [GO:1902618]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; embryonic skeletal system development [GO:0048706]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; intramembranous ossification [GO:0001957]; negative regulation of cell-substrate adhesion [GO:0010812]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein localization to nucleus [GO:0034504]; protein transport [GO:0015031]; response to cAMP [GO:0051591]; response to estradiol [GO:0032355]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skin development [GO:0043588]; skin morphogenesis [GO:0043589]; tooth mineralization [GO:0034505]; visual perception [GO:0007601] collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020] GPAGPPGR;GPPGSAGAPGKDGLNGLPGPIGPPGPRGR;GSPGPAGPK 3 3.1 0.95436 -0.9102 7.59552 0 0 0 0 0 0 12.6143 0 0 9.45619 0 P02458 CO2A1_HUMAN Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] COL2A1 Homo sapiens (Human) anterior head development [GO:0097065]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen type II trimer [GO:0005585]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; MHC class II protein binding [GO:0042289]; platelet-derived growth factor binding [GO:0048407]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394] IRLGAPQTLVLLTLLVAAVLR;SLNNQIESIR 2 2.1 0.91741 -0.35534 0 0 0 0 0 5.57809 0 0 6.32124 0 0 0 P02461 CO3A1_HUMAN Collagen alpha-1(III) chain COL3A1 Homo sapiens (Human) aorta smooth muscle tissue morphogenesis [GO:0060414]; basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; cellular response to amino acid stimulus [GO:0071230]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; digestive tract development [GO:0048565]; elastic fiber assembly [GO:0048251]; endochondral bone morphogenesis [GO:0060350]; extracellular matrix organization [GO:0030198]; fibroblast proliferation [GO:0048144]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; layer formation in cerebral cortex [GO:0021819]; limb joint morphogenesis [GO:0036022]; lung development [GO:0030324]; multicellular organism growth [GO:0035264]; negative regulation of immune response [GO:0050777]; negative regulation of neuron migration [GO:2001223]; neuron migration [GO:0001764]; peptide cross-linking [GO:0018149]; platelet activation [GO:0030168]; positive regulation of Rho protein signal transduction [GO:0035025]; response to angiotensin [GO:1990776]; response to cytokine [GO:0034097]; response to radiation [GO:0009314]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tissue homeostasis [GO:0001894]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 production [GO:0032905]; wound healing [GO:0042060] collagen type III trimer [GO:0005586]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; SMAD binding [GO:0046332] DGSPGGK;GETGAPGLK 2 1.1 0.90178 -0.26247 0 0 0 0 0 0 0 0 0 9.5019 13.7967 0 P02462 CO4A1_HUMAN Collagen alpha-1(IV) chain [Cleaved into: Arresten] COL4A1 Homo sapiens (Human) basement membrane organization [GO:0071711]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] CQVCMRR;GEPGLPGRGFPGFPGAK;GERGYPGTPGPR;GQIGPIGEKGSR;GQMGLSFQGPKGDK;SEMFKKPTPSTLKAGELR;THVSRCQVCMR 7 5.1 0.97672 -2.2806 0 0 8.75656 10.5981 9.44025 0 0 10.7852 0 0 9.44164 0 P02489 CRYAA_HUMAN Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) (Heat shock protein family B member 4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)] CRYAA CRYA1 HSPB4 Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intracellular transport [GO:0032387]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082] QDDHGYISREFHR 1 7.5 0.95231 -0.72132 0 0 0 0 0 0 0 0 0 0 0 8.57202 P02533 K1C14_HUMAN "Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)" KRT14 Homo sapiens (Human) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; response to radiation [GO:0009314]; stem cell differentiation [GO:0048863] basal part of cell [GO:0045178]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634] keratin filament binding [GO:1990254]; structural constituent of cytoskeleton [GO:0005200] ALEEANADLEVK;EVATNSELVQSGK;ILNEMRDQYEK;LAADDFR;LASYLDK;LASYLDKVR;LEQEIATYR;LEQEIATYRR;NHEEEMNALR;SEISELR;VLDELTLAR;VTMQNLNDR 12 20.6 0.92336 -0.44742 0 0 0 0 9.37473 0 0 0 0 0 0 0 P02545 LMNA_HUMAN Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] LMNA LMN1 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; cellular senescence [GO:0090398]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; heterochromatin formation [GO:0031507]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504]; regulation of cell migration [GO:0030334]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204]; ventricular cardiac muscle cell development [GO:0055015] cytosol [GO:0005829]; intermediate filament [GO:0005882]; lamin filament [GO:0005638]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of double-strand break [GO:0035861] identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of nuclear lamina [GO:0160123]; structural molecule activity [GO:0005198] AAYEAELGDAR;ASASGSGAQVGGPISSGSSASSVTVTR;ASSHSSQTQGGGSVTK;EAALSTALSEK;EELDFQKNIYSEELRETK;EGDLIAAQAR;IDSLSAQLSQLQK;ITESEEVVSR;KLESTESR;LADALQELR;LDNARQSAER;LEAALGEAK;LESTESR;LLEGEEER;LQLELSK;LQTMKEELDFQK;LSPSPTSQR;LVEIDNGK;LVEIDNGKQR;METPSQR;MQQQLDEYQELLDIK;NIYSEELR;NIYSEELRETK;NKSNEDQSMGNWQIKR;NSNLVGAAHEELQQSR;QLQDEMLR;QNGDDPLLTYR;SGAQASSTPLSPTR;SLETENAGLR;SVGGSGGGSFGDNLVTR;TALINSTGEEVAMR;TLDSVAK;VAVEEVDEEGK;VAVEEVDEEGKFVR 34 51.2 0 74.543 11.543 11.3534 10.0895 0 10.8714 10.5803 14.161 14.1559 14.8718 15.1666 15.5709 13.3519 P02549 SPTA1_HUMAN "Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)" SPTA1 SPTA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; hemopoiesis [GO:0030097]; lymphocyte homeostasis [GO:0002260]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200] DADDLGK;DIKGVSEETLKEFSTIYK;ELCAKAEK;GLERNLAVMSDK;LLEKQLPLQK;LNEASRQQR;QVKNFEMCQEFEQNASTFLQWILETR;SRVQKQQVFEK;TEVLHKK;VTILGETAERLSESHPDATEDLQRQK 10 5.5 0.97495 -3.8987 0 0 0 5.91421 7.70058 4.99413 10.6615 0 0 0 8.28068 11.9432 P02585 TNNC2_HUMAN "Troponin C, skeletal muscle" TNNC2 Homo sapiens (Human) regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009] cytosol [GO:0005829]; troponin complex [GO:0005861] calcium ion binding [GO:0005509] ASGEHVTDEEIESLMK 1 10 0.61386 0.1743 0 0 0 5.01823 0 0 0 0 0 0 0 0 P02647 APOA1_HUMAN Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] APOA1 Homo sapiens (Human) acylglycerol homeostasis [GO:0055090]; adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cellular response to lipoprotein particle stimulus [GO:0071402]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative chemotaxis [GO:0050919]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; apolipoprotein receptor binding [GO:0034190]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] LLDNWDSVTSTFSK;VQPYLDDFQKK 2 9.4 0.95276 -0.76718 0 0 0 0 0 0 0 0 0 10.3115 0 0 P02654 APOC1_HUMAN Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I] APOC1 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phosphatidylcholine catabolic process [GO:0010900]; negative regulation of receptor-mediated endocytosis [GO:0048261]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; phospholipid efflux [GO:0033700]; plasma lipoprotein particle remodeling [GO:0034369]; regulation of cholesterol transport [GO:0032374]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379]; very-low-density lipoprotein particle clearance [GO:0034447] chylomicron [GO:0042627]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361] fatty acid binding [GO:0005504]; lipase inhibitor activity [GO:0055102]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipase inhibitor activity [GO:0004859] EFGNTLEDK 1 10.8 0.909 -0.31585 0 0 8.86273 0 0 0 0 0 0 0 0 0 P02671 FIBA_HUMAN Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] FGA Homo sapiens (Human) "adaptive immune response [GO:0002250]; blood coagulation, common pathway [GO:0072377]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]" blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] DSDWPFCSDEDWNYKCPSGCR;GLIDEVNQDFTNRINK;RLEVDIDIKIR 3 5.5 0.98028 -1.5545 0 0 0 0 12.6673 0 0 0 3.38722 0 7.25418 8.96345 P02675 FIBB_HUMAN Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] FGB Homo sapiens (Human) "adaptive immune response [GO:0002250]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]" blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; synapse [GO:0045202] extracellular matrix structural constituent [GO:0005201]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] DLWQKRQK;DNDGWLTSDPRK;EEAPSLRPAPPPISGGGYR;REEAPSLRPAPPPISGGGYR;VLRSILENLRSK 5 10.6 0.97898 -1.9649 0 6.12565 10.8402 7.62249 0 8.56026 0 0 0 0 0 0 P02679 FIBG_HUMAN Fibrinogen gamma chain FGG PRO2061 Homo sapiens (Human) "blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; platelet maturation [GO:0036345]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]" blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] cell adhesion molecule binding [GO:0050839]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] LDGSVDFK 1 1.8 0.86516 -0.092078 0 0 0 0 0 9.71522 0 0 0 0 0 9.90515 P02686 MBP_HUMAN Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) MBP Homo sapiens (Human) axon ensheathment [GO:0008366]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; immune response [GO:0006955]; maintenance of blood-brain barrier [GO:0035633]; MAPK cascade [GO:0000165]; membrane organization [GO:0061024]; myelination [GO:0042552]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of metalloendopeptidase activity [GO:1904685]; response to toxic substance [GO:0009636]; sensory perception of sound [GO:0007605]; substantia nigra development [GO:0021762] cell periphery [GO:0071944]; cell surface [GO:0009986]; compact myelin [GO:0043218]; cytosol [GO:0005829]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] calmodulin binding [GO:0005516]; lipid binding [GO:0008289]; protease binding [GO:0002020]; structural constituent of myelin sheath [GO:0019911] GNHAGKRELNAEK;MGNHAGK 2 4.6 0.96321 -1.0866 0 0 0 0 0 0 8.32814 0 0 0 9.1966 0 P02689 MYP2_HUMAN Myelin P2 protein (Peripheral myelin protein 2) PMP2 Homo sapiens (Human) fatty acid transport [GO:0015908]; membrane organization [GO:0061024] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; nucleus [GO:0005634] cholesterol binding [GO:0015485]; fatty acid binding [GO:0005504] GSLNQVQRWDGK;LVSSENFDDYMK 2 18.2 0.95525 -0.826 0 0 0 0 0 0 0 0 10.1674 0 0 0 P02730 B3AT_HUMAN Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) SLC4A1 AE1 DI EPB3 Homo sapiens (Human) bicarbonate transport [GO:0015701]; blood coagulation [GO:0007596]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; erythrocyte development [GO:0048821]; intracellular monoatomic ion homeostasis [GO:0006873]; monoatomic anion transport [GO:0006820]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of urine volume [GO:0035811]; pH elevation [GO:0045852]; plasma membrane phospholipid scrambling [GO:0017121]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] ankyrin-1 complex [GO:0170014]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; hemoglobin binding [GO:0030492]; monoatomic anion transmembrane transporter activity [GO:0008509]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; solute:inorganic anion antiporter activity [GO:0005452] YHPDVPYVK 1 1 0.90944 -0.31579 0 0 7.95245 0 0 0 0 11.2298 0 0 0 0 P02741 CRP_HUMAN C-reactive protein [Cleaved into: C-reactive protein(1-205)] CRP PTX1 Homo sapiens (Human) acute-phase response [GO:0006953]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of mononuclear cell proliferation [GO:0032945]; opsonization [GO:0008228]; positive regulation of gene expression [GO:0010628]; positive regulation of superoxide anion generation [GO:0032930]; regulation of interleukin-8 production [GO:0032677]; vasoconstriction [GO:0042310] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; choline binding [GO:0033265]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750] GYSIFSYATK 1 4.5 0.88266 -0.17838 0 0 10.3332 0 0 0 0 0 0 0 10.9073 0 P02745 C1QA_HUMAN Complement C1q subcomponent subunit A C1QA Homo sapiens (Human) "astrocyte activation [GO:0048143]; cell-cell signaling [GO:0007267]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; complement-mediated synapse pruning [GO:0150062]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; neuron remodeling [GO:0016322]; synapse organization [GO:0050808]; synapse pruning [GO:0098883]; vertebrate eye-specific patterning [GO:0150064]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extrinsic component of postsynaptic membrane [GO:0098890]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; synapse [GO:0045202] amyloid-beta binding [GO:0001540] GIPGIKGTK 1 3.7 0.60096 0.17749 0 0 0 0 0 0 0 4.98828 0 0 8.95294 0 P02747 C1QC_HUMAN Complement C1q subcomponent subunit C C1QC C1QG Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of macrophage differentiation [GO:0045650]; synapse pruning [GO:0098883]" blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of postsynaptic membrane [GO:0098890]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; synapse [GO:0045202] LLLLLLLLPLR;MDVGPSSLPHLGLKLLLLLLLLPLR 2 10.2 0.8359 -0.030909 0 9.71112 0 0 0 0 0 0 6.2575 0 2.92172 0 P02748 CO9_HUMAN Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] C9 Homo sapiens (Human) "cell killing [GO:0001906]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]; protein homooligomerization [GO:0051260]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218]; plasma membrane [GO:0005886] LSPIYNLVPVKMKNAHLK;VVEESELAR 2 4.8 0.0046838 1.3936 0 0 11.5028 10.8115 0 0 9.61791 0 0 11.6276 11.8462 12.6785 P02749 APOH_HUMAN Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) APOH B2G1 Homo sapiens (Human) "blood coagulation, intrinsic pathway [GO:0007597]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; plasminogen activation [GO:0031639]; positive regulation of blood coagulation [GO:0030194]; positive regulation of lipoprotein lipase activity [GO:0051006]; regulation of fibrinolysis [GO:0051917]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]" cell surface [GO:0009986]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; platelet dense granule lumen [GO:0031089]; very-low-density lipoprotein particle [GO:0034361] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; phospholipid binding [GO:0005543] CFKEHSSLAFWK;VSFFCKNK 2 5.8 0.97537 -1.4543 0 0 0 0 0 0 0 11.2839 0 0 0 0 P02750 A2GL_HUMAN Leucine-rich alpha-2-glycoprotein (LRG) LRG1 LRG Homo sapiens (Human) "brown fat cell differentiation [GO:0050873]; keratinocyte migration [GO:0051546]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; response to bacterium [GO:0009617]; wound healing, spreading of epidermal cells [GO:0035313]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114] LRKLPPGLLANFTLLR 1 4.6 0.85884 -0.082467 0 0 0 0 5.22801 0 0 0 0 0 0 0 P02751 FINC_HUMAN Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] FN1 FN Homo sapiens (Human) "acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; biological process involved in interaction with symbiont [GO:0051702]; calcium-independent cell-matrix adhesion [GO:0007161]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; heart development [GO:0007507]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of monocyte activation [GO:0150102]; negative regulation of transforming growth factor beta production [GO:0071635]; nervous system development [GO:0007399]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; peptide cross-linking [GO:0018149]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; response to muscle activity [GO:0014850]; response to wounding [GO:0009611]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]" apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] DAPIVNK;IGEKWDR;LTVGLTRRGQPR;TSYRIGDTWSKK;VTIMWTPPESAVTGYR;VTWAPPPSIDLTNFLVR 6 2.9 0.97461 -2.3891 9.22108 11.9962 0 0 0 0 0 0 0 9.80445 6.87934 0 P02753 RET4_HUMAN Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)] RBP4 PRO2222 Homo sapiens (Human) cardiac muscle tissue development [GO:0048738]; embryonic organ morphogenesis [GO:0048562]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; female genitalia morphogenesis [GO:0048807]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; lung development [GO:0030324]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion [GO:0032024]; response to retinoic acid [GO:0032526]; retinol metabolic process [GO:0042572]; retinol transport [GO:0034633]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; visual perception [GO:0007601] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632] AERDCRVSSFR;MKWVWALLLLAALGSGR 2 13.9 0.91012 -0.29992 8.73907 0 0 0 0 0 11.3193 4.39197 0 0 0 0 P02763 A1AG1_HUMAN Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) ORM1 AGP1 Homo sapiens (Human) acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] QDQCIYNTTYLNVQR;YVGGQEHFAHLLILRDTK 2 16.4 0.9099 -0.27994 0 0 0 0 11.6098 0 0 0 8.62077 0 0 0 P02765 FETUA_HUMAN Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] AHSG FETUA PRO2743 Homo sapiens (Human) acute-phase response [GO:0006953]; negative regulation of bone mineralization [GO:0030502]; negative regulation of insulin receptor signaling pathway [GO:0046627]; ossification [GO:0001503]; pinocytosis [GO:0006907]; positive regulation of phagocytosis [GO:0050766]; regulation of bone mineralization [GO:0030500]; regulation of inflammatory response [GO:0050727]; skeletal system development [GO:0001501] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774] cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; kinase inhibitor activity [GO:0019210] CDSSPDSAEDVR;CDSSPDSAEDVRK;CNLLAEK 3 5.4 0 4.0483 0 10.5962 0 0 0 9.98171 0 0 0 10.8576 10.1366 6.40492 P02768 ALBU_HUMAN Albumin ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341 Homo sapiens (Human) cellular response to calcium ion starvation [GO:0072732]; cellular response to starvation [GO:0009267]; negative regulation of mitochondrial depolarization [GO:0051902] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991] antioxidant activity [GO:0016209]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; exogenous protein binding [GO:0140272]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643] AACLLPK;CCTESLVNR;DVFLGMFLYEYARR;ETYGEMADCCAK;KVPQVSTPTLVEVSR;LKECCEKPLLEK;LVTDLTK;VPQVSTPTLVEVSR;WVTFISLLFLFSSAYSR;YICENQDSISSK;YLYEIAR 11 18.4 0 76.448 18.8226 18.7043 18.6363 16.3978 16.3418 16.1453 16.3829 15.8839 17.2846 17.1741 17.8332 15.4925 P02771 FETA_HUMAN Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) AFP HPAFP Homo sapiens (Human) apoptotic process [GO:0006915]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; ovulation from ovarian follicle [GO:0001542]; progesterone metabolic process [GO:0042448] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] metal ion binding [GO:0046872] FLGDRDFNQFSSGEK;GYQELLEK;LVLDVAHVHEHCCR;RSCGLFQKLGEYYLQNAFLVAYTK 4 10 0.71059 0.15601 11.0312 11.9469 0 12.0342 11.0572 10.7689 0 0 11.7251 8.4219 11.0703 12.5217 P02774 VTDB_HUMAN Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf) GC Homo sapiens (Human) vitamin D metabolic process [GO:0042359]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202] actin binding [GO:0003779]; calcidiol binding [GO:1902118]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482] LCDNLSTK;LPDATPTELAK;NSKFEDCCQEK;RVLVLLLAVAFGHALER;VMDKYTFELSR 5 12.2 0.97668 -2.2405 0 0 0 9.06983 0 0 6.83996 0 0 0 0 8.01503 P02775 CXCL7_HUMAN Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; D-glucose transmembrane transport [GO:1904659]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell division [GO:0051781] extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; tertiary granule lumen [GO:1904724] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; D-glucose transmembrane transporter activity [GO:0055056]; growth factor activity [GO:0008083] EESLDSDLYAELRCMCIK 1 14.1 0.9199 -0.43788 0 0 0 0 0 0 0 0 0 0 7.77591 0 P02786 TFR1_HUMAN "Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]" TFRC Homo sapiens (Human) acute-phase response [GO:0006953]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to xenobiotic stimulus [GO:0071466]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial fusion [GO:0010637]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of isotype switching [GO:0045830]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to manganese ion [GO:0010042]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; transferrin transport [GO:0033572]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; HFE-transferrin receptor complex [GO:1990712]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; transferrin receptor activity [GO:0004998]; virus receptor activity [GO:0001618] DENLALYVENQFREFKLSK;DLNQYRADIK;LAVDEEENADNNTK;LDSTDFTGTIK;LLNENSYVPR;MVTSESK;SGVGTALLLK;SSGLPNIPVQTISR;VSASPLLYTLIEK 9 14.2 0 9.862 12.2203 13.5651 12.9245 10.448 7.80832 9.71927 12.4323 11.8057 11.7803 10.4142 12.2295 0 P02787 TRFE_HUMAN Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) TF PRO1400 Homo sapiens (Human) actin filament organization [GO:0007015]; antibacterial humoral response [GO:0019731]; cellular response to iron ion [GO:0071281]; ERK1 and ERK2 cascade [GO:0070371]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of phosphorylation [GO:0042327]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of iron ion transport [GO:0034756]; regulation of protein stability [GO:0031647] apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; basal plasma membrane [GO:0009925]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] enzyme binding [GO:0019899]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; transferrin receptor binding [GO:1990459]; transmembrane transporter binding [GO:0044325] GDVAFVK;KCSTSSLLEACTFR;TVRWCAVSEHEATK;VPPRMDAK 4 7.2 0.91653 -0.43465 0 0 0 0 8.34376 8.7129 0 0 0 10.3873 10.2675 11.1294 P02788 TRFL_HUMAN Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C] LTF GIG12 LF Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; bone morphogenesis [GO:0060349]; defense response to Gram-negative bacterium [GO:0050829]; humoral immune response [GO:0006959]; innate immune response in mucosa [GO:0002227]; iron ion transport [GO:0006826]; killing of cells of another organism [GO:0031640]; negative regulation by host of viral process [GO:0044793]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of osteoclast development [GO:2001205]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000308]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; ossification [GO:0001503]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteolysis [GO:0006508]; regulation of cytokine production [GO:0001817]; regulation of tumor necrosis factor production [GO:0032680] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; secretory granule [GO:0030141]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cysteine-type endopeptidase inhibitor activity [GO:0004869]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; iron ion binding [GO:0005506]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; protein serine/threonine kinase activator activity [GO:0043539]; serine-type endopeptidase activity [GO:0004252] CGLVPVLAENYK;DLLFKDSAIGFSR;KLVFLVLLFLGALGLCLAGR;RARVVWCAVGEQELR;YYGYTGAFR 5 9.7 0.81449 -0.0054398 12.6712 12.6471 12.3264 9.95096 10.4283 7.16038 0 0 12.4942 9.11551 12.5317 11.6605 P02790 HEMO_HUMAN Hemopexin (Beta-1B-glycoprotein) HPX Homo sapiens (Human) heme metabolic process [GO:0042168]; heme transport [GO:0015886]; hemoglobin metabolic process [GO:0020027]; intracellular iron ion homeostasis [GO:0006879]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; regulation of protein metabolic process [GO:0051246]; type II interferon-mediated signaling pathway [GO:0060333] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] heme transmembrane transporter activity [GO:0015232]; metal ion binding [GO:0046872] EWFWDLATGTMK;VWVYPPEK 2 4.3 0.92981 -0.48644 0 10.8073 0 5.29987 0 0 0 0 0 0 0 0 P02795 MT2_HUMAN Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) MT2A CES1 MT2 Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-3 [GO:0036016]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCAAGDSCTCAGSCKCK;GASDKCSCCA;KSCCSCCPVGCAK;MDPNCSCAAGDSCTCAGSCK;SCCSCCPVGCAKCAQGCICK 5 86.9 0.95815 -1.003 0 0 6.81724 7.59447 0 4.18595 0 5.80338 4.83152 0 0 6.25782 P03372 ESR1_HUMAN Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 Homo sapiens (Human) androgen metabolic process [GO:0008209]; antral ovarian follicle growth [GO:0001547]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; chromatin remodeling [GO:0006338]; epithelial cell development [GO:0002064]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; estrogen receptor signaling pathway [GO:0030520]; fibroblast proliferation [GO:0048144]; male gonad development [GO:0008584]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in pregnancy [GO:0060745]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; protein localization to chromatin [GO:0071168]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell apoptotic process [GO:1904035]; regulation of inflammatory response [GO:0050727]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; RNA polymerase II preinitiation complex assembly [GO:0051123]; signal transduction [GO:0007165]; stem cell differentiation [GO:0048863]; steroid hormone receptor signaling pathway [GO:0043401]; uterus development [GO:0060065]; vagina development [GO:0060068] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "14-3-3 protein binding [GO:0071889]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled estrogen receptor activity [GO:0038054]; identical protein binding [GO:0042802]; nitric-oxide synthase regulator activity [GO:0030235]; nuclear estrogen receptor activity [GO:0030284]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; TFIIB-class transcription factor binding [GO:0001093]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" ELVHMINWAKR;LASTNDK;LHAPTSR;TMTLHTK;YCAVCNDYASGYHYGVWSCEGCK 5 9.2 0.93993 -0.57915 0 0 0 0 7.82864 0 10.2834 7.90971 0 0 8.80832 5.07805 P03372 ESR1_HUMAN Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 Homo sapiens (Human) androgen metabolic process [GO:0008209]; antral ovarian follicle growth [GO:0001547]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; chromatin remodeling [GO:0006338]; epithelial cell development [GO:0002064]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; estrogen receptor signaling pathway [GO:0030520]; fibroblast proliferation [GO:0048144]; male gonad development [GO:0008584]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in pregnancy [GO:0060745]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; protein localization to chromatin [GO:0071168]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell apoptotic process [GO:1904035]; regulation of inflammatory response [GO:0050727]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; RNA polymerase II preinitiation complex assembly [GO:0051123]; signal transduction [GO:0007165]; stem cell differentiation [GO:0048863]; steroid hormone receptor signaling pathway [GO:0043401]; uterus development [GO:0060065]; vagina development [GO:0060068] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "14-3-3 protein binding [GO:0071889]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled estrogen receptor activity [GO:0038054]; identical protein binding [GO:0042802]; nitric-oxide synthase regulator activity [GO:0030235]; nuclear estrogen receptor activity [GO:0030284]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; TBP-class protein binding [GO:0017025]; TFIIB-class transcription factor binding [GO:0001093]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" AMESAKETRYCAVCNDYASGYHYGVWSCEGCK;ELVHMINWAKR;LHAPTSR;YCAVCNDYASGYHYGVWSCEGCK 4 11.8 0.61325 0.17447 4.20641 0 0 0 0 0 0 0 0 0 0 0 P03928 ATP8_HUMAN ATP synthase protein 8 (A6L) (F-ATPase subunit 8) MT-ATP8 ATP8 ATPASE8 MTATP8 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] MKNYNKPWEPK 1 16.2 0.87945 -0.15534 0 0 0 0 0 0 0 0 0 0 0 8.38982 P03950 ANGI_HUMAN Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) ANG RNASE5 Homo sapiens (Human) actin filament polymerization [GO:0030041]; angiogenesis [GO:0001525]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell communication [GO:0007154]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; hematopoietic stem cell proliferation [GO:0071425]; homeostatic process [GO:0042592]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation in response to stress [GO:0032055]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; placenta development [GO:0001890]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein secretion [GO:0050714]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; rRNA transcription [GO:0009303]; signal transduction [GO:0007165]; signaling [GO:0023052]; stress granule assembly [GO:0034063]; tRNA decay [GO:0016078] actin cytoskeleton [GO:0015629]; angiogenin-PRI complex [GO:0032311]; basement membrane [GO:0005604]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleus [GO:0005634] actin binding [GO:0003779]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; heparin binding [GO:0008201]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]; signaling receptor binding [GO:0005102]; tRNA-specific ribonuclease activity [GO:0004549] DDRYCESIMRR;GLTSPCK 2 12.2 0.94072 -0.60842 0 8.1128 0 0 0 0 0 8.97536 0 0 0 0 P03951 FA11_HUMAN Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] F11 Homo sapiens (Human) blood coagulation [GO:0007596]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type aminopeptidase activity [GO:0070009]; serine-type endopeptidase activity [GO:0004252] ILHGRGGISGYTLRLCK;ITHKMICAGYR 2 4.5 0.9741 -1.4043 0 4.60769 0 0 0 8.20486 0 0 0 0 0 0 P03952 KLKB1_HUMAN Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] KLKB1 KLK3 Homo sapiens (Human) blood coagulation [GO:0007596]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] AQMQSPA;GGDVASMYTPNAQYCQMR;MVCAGYK;VLTPDAFVCR;YQDYKITQR 5 8 0.97675 -2.24 10.2036 7.56932 0 0 0 0 0 0 0 9.81028 0 0 P03956 MMP1_HUMAN Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] MMP1 CLG Homo sapiens (Human) cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] IENYTPDLPR;VTGKPDAETLKVMK;WEQTHLTYR 3 7 0.95559 -0.94315 0 8.0574 12.3459 0 0 9.36918 0 0 9.00422 10.0426 10.1135 0 P03971 MIS_HUMAN Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS) AMH MIF Homo sapiens (Human) anti-Mullerian hormone receptor signaling pathway [GO:1990262]; cell-cell signaling [GO:0007267]; gonadal mesoderm development [GO:0007506]; Leydig cell differentiation [GO:0033327]; Mullerian duct regression [GO:0001880]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle development [GO:0001541]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; preantral ovarian follicle growth [GO:0001546]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; sex determination [GO:0007530]; sex differentiation [GO:0007548]; urogenital system development [GO:0001655] extracellular region [GO:0005576]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type II transforming growth factor beta receptor binding [GO:0005114] DLATFGVCNTGDR;LALDPDALAGFPQGLVNLSDPAALER 2 7 0.7029 0.16026 0 0 0 0 0 0 0 0 0 7.72322 9.47007 0 P03973 SLPI_HUMAN Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4) SLPI WAP4 WFDC4 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; immune response [GO:0006955]; innate immune response [GO:0045087]; modulation of process of another organism [GO:0035821]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; response to lipopolysaccharide [GO:0032496] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; specific granule lumen [GO:0035580] DNA binding [GO:0003677]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; serine-type endopeptidase inhibitor activity [GO:0004867] CCMGMCGK;DLKCCMGMCGK 2 8.3 0.95263 -0.76146 0 0 7.21539 0 0 0 0 6.44913 0 6.57658 0 0 P03999 OPSB_HUMAN Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP) OPN1SW BCP Homo sapiens (Human) cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; signal transduction [GO:0007165]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; signaling receptor activity [GO:0038023] AVAAQQQESATTQK 1 4.1 0.78374 0.0237 0 6.00623 0 0 0 0 0 0 0 0 0 0 P04003 C4BPA_HUMAN C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) C4BPA C4BP Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]; T cell mediated immunity [GO:0002456]" blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] RNA binding [GO:0003723] EEIIYECDK;TWYPEVPK 2 2.8 0.95991 -1.0503 0 0 0 0 0 9.76336 0 10.538 0 0 0 0 P04049 RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) RAF1 RAF Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; apoptotic process [GO:0006915]; death-inducing signaling complex assembly [GO:0071550]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of Rho protein signal transduction [GO:0035023]; response to muscle stretch [GO:0035994]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]; type II interferon-mediated signaling pathway [GO:0060333]; wound healing [GO:0042060] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LAFCDICQK 1 1.4 0.90964 -0.31554 0 0 0 0 0 0 0 7.91265 0 0 0 0 P04053 TDT_HUMAN DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase) DNTT TDT Homo sapiens (Human) DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; double-strand break repair via nonhomologous end joining [GO:0006303]; response to ATP [GO:0033198] cytosol [GO:0005829]; euchromatin [GO:0000791]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] AGKPVEMTGK;AVLNDERYQSFK 2 4.3 0.95505 -0.88233 9.0706 11.5647 0 0 0 0 0 0 0 11.3812 0 0 P04062 GBA1_HUMAN Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Beta-glucosylceramidase 1) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Glucosylceramidase beta 1) (Imiglucerase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase) GBA1 GBA GC GLUC Homo sapiens (Human) antigen processing and presentation [GO:0019882]; autophagosome organization [GO:1905037]; autophagy [GO:0006914]; beta-glucoside catabolic process [GO:1901805]; brain morphogenesis [GO:0048854]; cell maturation [GO:0048469]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; cerebellar Purkinje cell layer formation [GO:0021694]; cholesterol metabolic process [GO:0008203]; determination of adult lifespan [GO:0008340]; establishment of skin barrier [GO:0061436]; glucosylceramide catabolic process [GO:0006680]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; lymphocyte migration [GO:0072676]; lysosome organization [GO:0007040]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitophagy [GO:0000423]; motor behavior [GO:0061744]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein lipidation [GO:1903061]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; pyramidal neuron differentiation [GO:0021859]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of TOR signaling [GO:0032006]; respiratory electron transport chain [GO:0022904]; response to dexamethasone [GO:0071548]; response to estrogen [GO:0043627]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; sphingosine biosynthetic process [GO:0046512]; T cell differentiation in thymus [GO:0033077]; termination of signal transduction [GO:0023021] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; trans-Golgi network [GO:0005802] galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]; steryl-beta-glucosidase activity [GO:0050295] DLGPTLANSTHHNVRLLMLDDQRLLLPHWAK;FLDAYAEHK 2 7.5 0.97212 -1.3569 0 0 0 0 0 0 11.4707 0 0 0 0 12.5753 P04066 FUCO_HUMAN Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-L-fucosidase activity [GO:0004560] TQHFVSAK;YGLYHSLLEWFHPLYLLDK 2 5.8 0.90093 -0.25978 0 10.4346 0 0 0 0 0 0 0 0 0 7.45467 P04070 PROC_HUMAN Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] PROC Homo sapiens (Human) blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] EAPQKSWAP;EVFVHPNYSK;LIDGKMTRR 3 6.1 0.90127 -0.26069 0 0 0 0 0 0 10.2129 10.2285 10.7174 0 0 0 P04075 ALDOA_HUMAN Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) ALDOA ALDA Homo sapiens (Human) "actin filament organization [GO:0007015]; ATP biosynthetic process [GO:0006754]; binding of sperm to zona pellucida [GO:0007339]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; glycolytic process [GO:0006096]; muscle cell cellular homeostasis [GO:0046716]; protein homotetramerization [GO:0051289]; regulation of cell shape [GO:0008360]; striated muscle contraction [GO:0006941]" actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; I band [GO:0031674]; M band [GO:0031430]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774]; sperm head [GO:0061827]; tertiary granule lumen [GO:1904724] actin binding [GO:0003779]; cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tubulin binding [GO:0015631] AAQEEYVK;AAQEEYVKR;ADDGRPFPQVIK;ALQASALK;CQYVTEK;DGADFAK;ELATTSTMPYQYPALTPEQK;ELSDIAHR;GILAADESTGSIAK;GVVPLAGTNGETTTQGLDGLSER;IGEHTPSALAIMENANVLAR;LQSIGTENTEENR;LQSIGTENTEENRR;QLLLTADDR;TVPPAVTGITFLSGGQSEEEASINLNAINK;VLAAVYK;YTPSGQAGAAASESLFVSNHAY 17 50.2 0 140.76 13.8539 14.9267 14.9294 12.1743 12.0067 12.6581 13.9507 14.1797 14.1194 14.0423 14.4252 14.4321 P04080 CYTB_HUMAN Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) CSTB CST6 STFB Homo sapiens (Human) adult locomotory behavior [GO:0008344]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; RNA binding [GO:0003723] FPVFKAVSFKSQVVAGTNYFIK;SQVVAGTNYFIK 2 22.4 0.039711 0.52094 0 0 0 0 0 0 0 0 0 9.68828 9.7261 0 P04083 ANXA1_HUMAN Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] ANXA1 ANX1 LPC1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; arachidonate secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; keratinocyte differentiation [GO:0030216]; monocyte chemotaxis [GO:0002548]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of exocytosis [GO:0045920]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; neutrophil activation [GO:0042119]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of vesicle fusion [GO:0031340]; positive regulation of wound healing [GO:0090303]; regulation of cell shape [GO:0008360]; regulation of hormone secretion [GO:0046883]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 production [GO:0032652]; regulation of leukocyte migration [GO:0002685]; signal transduction [GO:0007165]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; vesicle [GO:0031982]; vesicle membrane [GO:0012506] cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102] AAYLQETGKPLDETLKK;AFYQKMYGISLCQAILDETKGDYEK;ALYEAGER;AMVSEFLK;DITSDTSGDFR;GGPGSAVSPYPTFNPSSDVAALHK;GLGTDEDTLIEILASR;GTDVNVFNTILTTR;GVDEATIIDILTK;GVGTRHK;QAWFIENEEQEYVQTVK;SEDFGVNEDLADSDAR;SEIDMNDIK;TPAQFDADELR;VLDLELKGDIEK 15 60.1 0 112.53 0 9.00506 4.91624 0 3.73021 0 13.594 13.0853 13.9834 12.8222 13.1121 12.8822 P04114 APOB_HUMAN Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] APOB Homo sapiens (Human) artery morphogenesis [GO:0048844]; cellular response to lipoprotein particle stimulus [GO:0071402]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; regulation of cholesterol biosynthetic process [GO:0045540]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642]; very-low-density lipoprotein particle assembly [GO:0034379] chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; low-density lipoprotein particle [GO:0034362]; lysosomal lumen [GO:0043202]; mature chylomicron [GO:0034359]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; phospholipid binding [GO:0005543]; receptor ligand activity [GO:0048018] AEPLAFTFSHDYKGSTSHHLVSR;EIFNMARDQR;EQHLFLPFSYKNK;GKEKIAELSATAQEIIK;GVISIPR;HLIDSLIDFLNFPR;INNQLTLDSNTK;ITEVALMGHLSCDTKEER;IVSLIKNLLVALK;LAIPEGK;LALWGEHTGQLYSK;LDVTTSIGRRQHLR;LNELSFKTFIEDVNKFLDMLIK;LVGFIDDAVKK;NFATSNK;SFDYHQFVDETNDK;SISAALEHK;TEVIPPLIENR;TFIEDVNK;TFIEDVNKFLDMLIKK;VLVDHFGYTKDDK;VTQEFHMK 22 5.7 0.97858 -8.8642 6.98071 10.5681 9.22851 10.168 15.1481 9.66512 11.1009 10.651 12.3427 12.0528 11.6296 9.03006 P04150 GCR_HUMAN Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) NR3C1 GRL Homo sapiens (Human) "adrenal gland development [GO:0030325]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; cell division [GO:0051301]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; gene expression [GO:0010467]; glucocorticoid metabolic process [GO:0008211]; mammary gland duct morphogenesis [GO:0060603]; maternal behavior [GO:0042711]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucocorticoid biosynthetic process [GO:0031946]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]" centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synapse [GO:0045202] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; estrogen response element binding [GO:0034056]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor activity [GO:0004883]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]" IMTTLNMLGGR;LQVSYEEYLCMK 2 3 0.92891 -0.46113 10.4604 8.86273 0 0 0 0 0 0 0 0 9.96457 0 P04179 SODM_HUMAN "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Homo sapiens (Human) acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0003069]; cellular response to ethanol [GO:0071361]; cellular response to oxidative stress [GO:0034599]; detection of oxygen [GO:0003032]; erythrophore differentiation [GO:0048773]; glutathione metabolic process [GO:0006749]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular oxygen homeostasis [GO:0032364]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of membrane hyperpolarization [GO:1902631]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron development [GO:0048666]; positive regulation of cell migration [GO:0030335]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905932]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; respiratory electron transport chain [GO:0022904]; response to activity [GO:0014823]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to electrical stimulus [GO:0051602]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to L-ascorbic acid [GO:0033591]; response to lipopolysaccharide [GO:0032496]; response to magnetism [GO:0071000]; response to manganese ion [GO:0010042]; response to selenium ion [GO:0010269]; response to silicon dioxide [GO:0034021]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784] GDVTAQIALQPALK;YQEALAK 2 9.5 0 4.0121 0 0 0 0 0 0 0 0 0 0 0 10.4708 P04181 OAT_HUMAN "Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]" OAT Homo sapiens (Human) arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; visual perception [GO:0007601] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; ornithine aminotransferase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170] GLLNAIVIKETK;LPSDVVTAVR;NELMKLPSDVVTAVRGK;YKAKIVFAAGNFWGR 4 10 0.012072 0.83637 10.0021 11.4593 0 0 0 0 8.49981 0 0 0 9.16626 0 P04216 THY1_HUMAN Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90) THY1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection regeneration [GO:0070571]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell activation [GO:0050870]; receptor clustering [GO:0043113]; regulation of cell-matrix adhesion [GO:0001952]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; retinal cone cell development [GO:0046549]; T cell receptor signaling pathway [GO:0050852] apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] GPI anchor binding [GO:0034235]; GTPase activator activity [GO:0005096]; integrin binding [GO:0005178] VTSLTACLVDQSLR 1 8.7 0.78264 0.022528 0 10.2229 0 0 0 0 0 0 0 0 0 0 P04217 A1BG_HUMAN Alpha-1B-glycoprotein (Alpha-1-B glycoprotein) A1BG Homo sapiens (Human) immune response-regulating signaling pathway [GO:0002764] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774] HQFLLTGDTQGR 1 2.4 0.80731 0.01199 11.1611 0 0 0 0 0 0 0 0 0 0 0 P04234 CD3D_HUMAN T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d) CD3D T3D Homo sapiens (Human) adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; positive thymic T cell selection [GO:0045059]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] IPIEELEDR 1 5.3 0.90929 -0.31499 0 0 11.1706 0 0 0 0 0 0 0 0 0 P04259 K2C6B_HUMAN "Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)" KRT6B K6B KRTL1 Homo sapiens (Human) ectoderm development [GO:0007398]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] AQYEEIAQR;EYQELMNVK;FASFIDK;FASFIDKVR;FLEQQNK;NLDLDSIIAEVK;QDLARLLKEYQELMNVK;YEELQITAGR 8 11.3 0.856 -0.080618 0 0 0 0 0 0 0 7.76547 0 0 0 0 P04264 K2C1_HUMAN "Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)" KRT1 KRTA Homo sapiens (Human) "complement activation, lectin pathway [GO:0001867]; establishment of skin barrier [GO:0061436]; fibrinolysis [GO:0042730]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of inflammatory response [GO:0050728]; peptide cross-linking [GO:0018149]; protein heterotetramerization [GO:0051290]; regulation of angiogenesis [GO:0045765]; response to oxidative stress [GO:0006979]" blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] carbohydrate binding [GO:0030246]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; structural constituent of skin epidermis [GO:0030280] AEAESLYQSK;AQYEDIAQK;DVDGAYMTK;DYQELMNTK;FLEQQNQVLQTK;GGGGGGYGSGGSSYGSGGGSYGSGGGGGGGR;GSGGGSSGGSIGGR;IEISELNR;LNDLEDALQQAK;NMQDMVEDYR;QISNLQQSISDAEQR;SLDLDSIIAEVK;SLNNQFASFIDK;SLNNQFASFIDKVR;SLVNLGGSK;TLLEGEESR;TNAENEFVTIK;TNAENEFVTIKK;WELLQQVDTSTR;YEELQITAGR 20 33.7 0 199.44 14.1629 15.5304 13.9559 14.3817 13.969 14.4327 14.3357 13.9887 14.8155 15.5311 15.0784 14.3582 P04275 VWF_HUMAN von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] VWF F8VWF Homo sapiens (Human) blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; hemostasis [GO:0007599]; platelet activation [GO:0030168]; positive regulation of intracellular signal transduction [GO:1902533]; response to wounding [GO:0009611] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; Weibel-Palade body [GO:0033093] collagen binding [GO:0005518]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; integrin binding [GO:0005178]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087] HCDGNVSSCGDHPSEGCFCPPDK;IDGSGNFQVLLSDR;KKVIVIPVGIGPHANLK;LVCPADNLR;SLSYPDEECNEACLEGCFCPPGLYMDER 5 3.2 0.89309 -0.2215 6.17842 0 0 0 0 0 9.12503 2.69895 8.69108 10.9902 0 5.79992 P04278 SHBG_HUMAN Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin) SHBG Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular region [GO:0005576] androgen binding [GO:0005497]; steroid binding [GO:0005496] ESRGPLATSRLLLLLLLLLLR;GPLATSRLLLLLLLLLLR;GPLATSRLLLLLLLLLLRHTR;LLLLLLLLLLR;LLLLLLLLLLRHTR 5 6 0.86996 -0.091198 0 0 6.10723 4.6663 0 2.65922 3.01173 8.69686 0 5.37518 0 0 P04279 SEMG1_HUMAN Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein] SEMG1 SEMG Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; coagulation [GO:0050817]; insemination [GO:0007320]; killing of cells of another organism [GO:0031640]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] zinc ion binding [GO:0008270] LVAGKSQIQAPNPK 1 3 0.95139 -0.70501 0 0 0 0 6.68888 0 0 0 0 10.6668 0 0 P04406 G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) GAPDH GAPD CDABP0047 OK/SW-cl.12 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to type II interferon [GO:0071346]; defense response to fungus [GO:0050832]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of translation [GO:0017148]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of type I interferon production [GO:0032481]; protein stabilization [GO:0050821]; regulation of macroautophagy [GO:0016241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GAIT complex [GO:0097452]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] aspartic-type endopeptidase inhibitor activity [GO:0019828]; disordered domain specific binding [GO:0097718]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; peptidyl-cysteine S-nitrosylase activity [GO:0035605] AAFNSGK;AENGKLVINGNPITIFQER;AGAHLQGGAK;GALQNIIPASTGAAK;GALQNIIPASTGAAKAVGK;IISNASCTTNCLAPLAK;IKWGDAGAEYVVESTGVFTTMEK;LISWYDNEFGYSNR;LTGMAFR;LVINGNPITIFQER;LVINGNPITIFQERDPSK;QASEGPLK;TVDGPSGK;VGVNGFGR;VIISAPSADAPMFVMGVNHEK;VIISAPSADAPMFVMGVNHEKYDNSLK;VIPELNGK;VIPELNGKLTGMAFR;VPTANVSVVDLTCR;VVDLMAHMASK;VVDLMAHMASKE;WGDAGAEYVVESTGVFTTMEK 22 61.2 0 140.59 16.9496 15.7533 15.6006 12.84 13.9094 12.8618 16.0702 16.4487 17.2956 16.1382 16.315 15.6728 P04424 ARLY_HUMAN Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) ASL Homo sapiens (Human) ammonia assimilation cycle [GO:0019676]; arginine biosynthetic process via ornithine [GO:0042450]; arginine metabolic process [GO:0006525]; L-arginine biosynthetic process [GO:0006526]; locomotory behavior [GO:0007626]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; post-embryonic development [GO:0009791]; urea cycle [GO:0000050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] argininosuccinate lyase activity [GO:0004056]; identical protein binding [GO:0042802] NDQVVTDLR 1 1.9 0.90999 -0.31654 0 0 0 9.68715 0 0 0 0 0 0 0 0 P04432 KVD39_HUMAN Immunoglobulin kappa variable 1D-39 (Ig kappa chain V-I region Daudi) IGKV1D-39 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] VPAQLLGLLLLWLRGAR 1 14.5 0.82904 -0.02271 0 0 11.5186 0 0 0 9.92092 0 0 0 0 0 P04553 HSP1_HUMAN Sperm protamine P1 (Cysteine-rich protamine) PRM1 Homo sapiens (Human) chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786] DNA binding [GO:0003677] RAMRCCRPR 1 17.6 0.97633 -1.4832 0 0 0 0 0 0 12.208 0 0 0 0 0 P04554 PRM2_HUMAN Protamine-2 (Sperm histone P2) (Sperm protamine P2) [Cleaved into: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; Sperm histone HP4 (Sperm protamine P4); Sperm histone HP2 (Sperm protamine P2) (P2'); Sperm histone HP3 (P2'') (Sperm protamine P3)] PRM2 Homo sapiens (Human) chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; nucleus organization [GO:0006997]; sequestering of metal ion [GO:0051238]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] cadmium ion binding [GO:0046870]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] LPGPLTPSWKLRK 1 9.3 0.96483 -1.164 0 0 0 0 0 0 9.99449 0 0 0 0 0 P04626 ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) ERBB2 HER2 MLN19 NEU NGL Homo sapiens (Human) cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; Schwann cell development [GO:0014044]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; semaphorin receptor complex [GO:0002116] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; ErbB-3 class receptor binding [GO:0043125]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase I core binding [GO:0001042]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ASPLTSIISAVVGILLVVVLGVVFGILIKR;GPLPTDCCHEQCAAGCTGPK;TVCAGGCARCK;VLGSGAFGTVYK 4 5.8 0.37872 0.22142 0 0 0 0 0 0 6.48107 4.50468 0 0 0 0 P04626 ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) ERBB2 HER2 MLN19 NEU NGL Homo sapiens (Human) cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; Schwann cell development [GO:0014044]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; semaphorin receptor complex [GO:0002116] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; ErbB-3 class receptor binding [GO:0043125]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase I core binding [GO:0001042]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AGGSTQHLQRDTYGREPR;GPLPTDCCHEQCAAGCTGPK;TVCAGGCARCK;VLDTPGR;VLGSGAFGTVYK 5 7.7 0.95431 -0.91363 0 0 0 0 5.41207 0 7.83238 7.99311 0 0 9.22371 5.78589 P04628 WNT1_HUMAN Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog) WNT1 INT1 Homo sapiens (Human) animal organ regeneration [GO:0031100]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone development [GO:0060348]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system morphogenesis [GO:0021551]; cerebellum formation [GO:0021588]; diencephalon development [GO:0021536]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; fat cell differentiation [GO:0045444]; forebrain anterior/posterior pattern specification [GO:0021797]; hematopoietic stem cell proliferation [GO:0071425]; hepatocyte differentiation [GO:0070365]; inner ear morphogenesis [GO:0042472]; midbrain development [GO:0030901]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary maturation during brain development [GO:0022004]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cellular senescence [GO:2000773]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; neuron fate determination [GO:0048664]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to wounding [GO:0009611]; signal transduction in response to DNA damage [GO:0042770]; Spemann organizer formation [GO:0060061]; spinal cord association neuron differentiation [GO:0021527]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; morphogen activity [GO:0016015]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018] AVGDVLR;CNCTFHWCCHVSCR;SCSEGSIESCTCDYR 3 9.7 0.874 -0.11735 7.3014 0 0 8.53528 0 8.58097 0 9.47037 5.33543 0 0 0 P04632 CPNS1_HUMAN Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) CAPNS1 CAPN4 CAPNS Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; regulation of macroautophagy [GO:0016241] calpain complex [GO:0110158]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] MFLVNSFLK 1 3.4 0 7.0618 0 0 0 0 6.05959 0 9.6768 9.26 7.93729 0 0 8.7808 P04637 P53_HUMAN Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) TP53 P53 Homo sapiens (Human) "autophagy [GO:0006914]; B cell lineage commitment [GO:0002326]; bone marrow development [GO:0048539]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; cellular response to UV-C [GO:0071494]; cellular response to xenobiotic stimulus [GO:0071466]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; chromosome organization [GO:0051276]; circadian behavior [GO:0048512]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; embryonic organ development [GO:0048568]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; fibroblast proliferation [GO:0048144]; gastrulation [GO:0007369]; glial cell proliferation [GO:0014009]; glucose catabolic process to lactate via pyruvate [GO:0019661]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial DNA repair [GO:0043504]; mitophagy [GO:0000423]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism growth [GO:0035264]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1 to G0 transition [GO:1903451]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of helicase activity [GO:0051097]; negative regulation of miRNA processing [GO:1903799]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of pentose-phosphate shunt [GO:1905856]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; protein-containing complex assembly [GO:0065003]; Ras protein signal transduction [GO:0007265]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of fibroblast apoptotic process [GO:2000269]; regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to salt stress [GO:0009651]; response to X-ray [GO:0010165]; rRNA transcription [GO:0009303]; signal transduction by p53 class mediator [GO:0072331]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell proliferation involved in immune response [GO:0002309]; thymocyte apoptotic process [GO:0070242]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; viral process [GO:0016032]" centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; germ cell nucleus [GO:0043073]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] "14-3-3 protein binding [GO:0071889]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; copper ion binding [GO:0005507]; core promoter sequence-specific DNA binding [GO:0001046]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein phosphatase 2A binding [GO:0051721]; protein-folding chaperone binding [GO:0051087]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" AHSSHLK;EPGGSRAHSSHLK;GEPHHELPPGSTKR 3 6.9 0.68075 0.16476 0 0 0 0 0 3.23212 10.9468 0 0 0 8.22978 0 P04731 MT1A_HUMAN Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA) MT1A MT1S Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCATGGSCTCTGSCK;DPNCSCATGGSCTCTGSCKCKECK;KSCCSCCPMSCAK;KSCCSCCPMSCAKCAQGCICK;MDPNCSCATGGSCTCTGSCK;MDPNCSCATGGSCTCTGSCKCKECK;SCCSCCPMSCAK 7 75.4 0.012097 0.84041 8.74672 7.78274 5.30615 0 5.8937 4.72121 0 0 7.09223 8.05534 7.44228 4.4081 P04732 MT1E_HUMAN Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE) MT1E Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] KSCCSCCPVGCAK;SCCSCCPVGCAKCAQGCVCK;SCCSCCPVGCAKCAQGCVCKGASEK 3 42.6 0.87375 -0.11892 0 0 4.38281 0 7.77867 0 0 0 0 0 0 0 P04733 MT1F_HUMAN Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF) MT1F PRO0376 Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] CAQGCVCKGASEKCSCCD;GASEKCSCCD;MDPNCSCAAGVSCTCAGSCK;MDPNCSCAAGVSCTCAGSCKCK;SCCSCCPVGCSK;SCCSCCPVGCSKCAQGCVCK 6 85.2 0.72744 0.12563 5.68908 6.78293 0 0 7.54952 8.25814 7.34216 0 0 0 7.0468 0 P04792 HSPB1_HUMAN Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chaperone-mediated protein folding [GO:0061077]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor production [GO:0032760]; protein refolding [GO:0042026]; regulation of autophagy [GO:0010506]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein phosphorylation [GO:0001932]; regulation of translational initiation [GO:0006446]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] axon cytoplasm [GO:1904115]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; spindle [GO:0005819]; Z disc [GO:0030018] identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; unfolded protein binding [GO:0051082] AQLGGPEAAK;DGVVEITGK;LATQSNEITIPVTFESR;LFDQAFGLPR;QLSSGVSEIR;VSLDVNHFAPDELTVK 6 35.1 0 29.72 0 3.30334 0 0 0 0 11.6265 13.477 12.81 10.7981 13.1825 12.5651 P04798 CP1A1_HUMAN Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1A1 Homo sapiens (Human) "9-cis-retinoic acid biosynthetic process [GO:0042904]; amine metabolic process [GO:0009308]; camera-type eye development [GO:0043010]; cellular response to copper ion [GO:0071280]; cellular response to organic cyclic compound [GO:0071407]; coumarin metabolic process [GO:0009804]; dibenzo-p-dioxin catabolic process [GO:0019341]; digestive tract development [GO:0048565]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; ethylene metabolic process [GO:0009692]; fatty acid metabolic process [GO:0006631]; flavonoid metabolic process [GO:0009812]; hepatocyte differentiation [GO:0070365]; hydrogen peroxide biosynthetic process [GO:0050665]; insecticide metabolic process [GO:0017143]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; maternal process involved in parturition [GO:0060137]; nitric oxide metabolic process [GO:0046209]; omega-hydroxylase P450 pathway [GO:0097267]; phenol-containing compound metabolic process [GO:0018958]; porphyrin-containing compound metabolic process [GO:0006778]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to 3-methylcholanthrene [GO:1904681]; response to Aroclor 1254 [GO:1904010]; response to arsenic-containing substance [GO:0046685]; response to diphenyl ether [GO:1901497]; response to food [GO:0032094]; response to genistein [GO:0033595]; response to herbicide [GO:0009635]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to iron(III) ion [GO:0010041]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to vitamin A [GO:0033189]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; tissue remodeling [GO:0048771]; vitamin D metabolic process [GO:0042359]; xenobiotic metabolic process [GO:0006805]" endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "arachidonate monooxygenase activity [GO:0008391]; demethylase activity [GO:0032451]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; flavonoid 3'-monooxygenase activity [GO:0016711]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxygen binding [GO:0019825]; vitamin D 24-hydroxylase activity [GO:0070576]" CVFVNQWQINHDQK;EHYKTFEK;YVVVSVTNVICAICFGR 3 7.6 0.89351 -0.22614 0 0 5.61577 0 0 10.025 12.3229 0 2.32005 0 0 0 P04818 TYSY_HUMAN Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) TYMS TS OK/SW-cl.29 Homo sapiens (Human) cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; developmental growth [GO:0048589]; DNA biosynthetic process [GO:0071897]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; intestinal epithelial cell maturation [GO:0060574]; liver regeneration [GO:0097421]; methylation [GO:0032259]; negative regulation of translation [GO:0017148]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; tetrahydrofolate interconversion [GO:0035999]; uracil metabolic process [GO:0019860] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] folic acid binding [GO:0005542]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; sequence-specific mRNA binding [GO:1990825]; thymidylate synthase activity [GO:0004799] IQLQREPRPFPK 1 3.8 0.92424 -0.4503 0 0 0 0 0 0 0 0 4.67621 0 0 0 P04839 CY24B_HUMAN NADPH oxidase 2 (EC 1.6.3.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB NOX2 Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to ethanol [GO:0071361]; cellular response to L-glutamine [GO:1904845]; defense response [GO:0006952]; hydrogen peroxide biosynthetic process [GO:0050665]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of angiogenesis [GO:0045766]; positive regulation of tumor necrosis factor production [GO:0032760]; respiratory burst [GO:0045730]; response to aldosterone [GO:1904044]; response to angiotensin [GO:1990776]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; perinuclear endoplasmic reticulum [GO:0097038]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] VYDIPPKFFYTRK 1 2.3 0.86459 -0.089858 0 0 0 0 6.69613 0 0 0 0 0 0 0 P04843 RPN1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) RPN1 Homo sapiens (Human) protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723] ALTSEIALLQSR;ATSFLLALEPELEAR;FPLFGGWK;GEDEEENNLEVR;IDHILDAL;LPVALDPGAK;NIEIDSPYEISR;QPDSGISSIR;SAVEAER 9 15.5 0 11.367 13.3848 12.8297 13.154 9.43419 9.50299 0 9.44325 9.73738 11.5696 10.8559 10.5025 9.22733 P04844 RPN2_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Homo sapiens (Human) protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; oligosaccharyltransferase complex [GO:0008250] FELDTSER;FPEEEAPSTVLSQNLFTPKQEIQHLFR;MLAQQAVK 3 6.8 0.96396 -1.1837 0 0 0 0 0 0 0 0 0 11.0052 0 0 P04920 B3A2_HUMAN Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) SLC4A2 AE2 EPB3L1 HKB3 MPB3L Homo sapiens (Human) "amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; digestive tract development [GO:0048565]; monoatomic anion transport [GO:0006820]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; osteoclast differentiation [GO:0030316]; positive regulation of enamel mineralization [GO:0070175]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of intracellular pH [GO:0051453]; spermatogenesis [GO:0007283]; transmembrane transport [GO:0055085]" apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] chloride:bicarbonate antiporter activity [GO:0140900]; enzyme binding [GO:0019899]; monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857] NQEPQWR;SKHELKLLEK;WGKPHVASLSFR 3 2.3 0.94264 -0.62206 0 0.428571 0 8.21043 0 8.08119 0 0 0 0 0 8.95073 P05000 IFNW1_HUMAN Interferon omega-1 (Interferon alpha-II-1) IFNW1 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; regulation of cell cycle [GO:0051726]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] ISPFLCLK 1 4.1 0.9139 -0.39033 0 0 0 10.8188 0 0 0 0 0 0 0 0 P05019 IGF1_HUMAN Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C) IGF1 IBP1 IGF-1 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; bone mineralization involved in bone maturation [GO:0035630]; cell activation [GO:0001775]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to amyloid-beta [GO:1904646]; epithelial to mesenchymal transition [GO:0001837]; glycolate metabolic process [GO:0009441]; insulin-like growth factor receptor signaling pathway [GO:0048009]; muscle hypertrophy [GO:0014896]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; myotube cell development [GO:0014904]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of oocyte development [GO:0060283]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of trophectodermal cell proliferation [GO:1904075]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein stabilization [GO:0050821]; proteoglycan biosynthetic process [GO:0030166]; Ras protein signal transduction [GO:0007265]; regulation of gene expression [GO:0010468]; response to heat [GO:0009408]; signal transduction [GO:0007165]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; skeletal system development [GO:0001501]; wound healing [GO:0042060] alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; platelet alpha granule lumen [GO:0031093] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178] KGSTFEERK 1 5.7 0.87821 -0.13724 0 0 0 0 8.49993 0 0 0 0 0 0 0 P05023 AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) ATP1A1 Homo sapiens (Human) cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to steroid hormone stimulus [GO:0071383]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of glucocorticoid biosynthetic process [GO:0031947]; negative regulation of heart contraction [GO:0045822]; osmosensory signaling pathway [GO:0007231]; positive regulation of heart contraction [GO:0045823]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of sodium ion transport [GO:0002028]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to glycoside [GO:1903416]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376] apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; organelle membrane [GO:0031090]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid hormone binding [GO:1990239]; transmembrane transporter binding [GO:0044325] AAVPDAVGK;AAVPDAVGKCR;AVAGDASESALLK;AVFQANQENLPILK;DGPNALTPPPTTPEWIK;GIVVYTGDR;GVGIISEGNETVEDIAAR;IVEIPFNSTNK;LNIPVSQVNPR;NSVFQQGMK;QGAIVAVTGDGVNDSPALK;SPDFTNENPLETR;TGTLTQNR;VIMVTGDHPITAK 14 16.2 0 17.426 13.3738 13.4703 13.6843 9.72695 9.76147 10.0503 11.5676 11.8572 9.8133 13.0737 11.9992 10.9766 P05026 AT1B1_HUMAN Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) ATP1B1 ATP1B Homo sapiens (Human) ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; innate immune response [GO:0045087]; intracellular calcium ion homeostasis [GO:0006874]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; protein transport into plasma membrane raft [GO:0044861]; proton transmembrane transport [GO:1902600]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of gene expression [GO:0010468]; relaxation of cardiac muscle [GO:0055119]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; MHC class II protein complex binding [GO:0023026]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674] VAPPGLTQIPQIQK 1 4.6 0.92058 -0.43709 9.96766 0 0 0 0 0 0 0 0 9.76749 9.33878 0 P05060 SCG1_HUMAN Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] CHGB SCG1 Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; secretory granule [GO:0030141] hormone activity [GO:0005179] ADQTVLTEDEK;ENREEARFQDK;KPFSEDVNWGYEK;KRLGELFNPYYDPLQWK;RNYPSLELDK;WQQQGDLQDTK 6 10.8 0.97321 -2.873 13.9149 8.91886 0 0 0 5.89035 11.1335 0 0 0 6.99741 0 P05062 ALDOB_HUMAN Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) ALDOB ALDB Homo sapiens (Human) "fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; NADH oxidation [GO:0006116]; negative regulation of pentose-phosphate shunt [GO:1905856]; positive regulation of ATP-dependent activity [GO:0032781]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]" centriolar satellite [GO:0034451]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815] ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; fructose binding [GO:0070061]; fructose-1-phosphate aldolase activity [GO:0061609]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] ETTIQGLDGLSER;MAHRFPALTQEQK;VLAAVYK 3 9.1 0.95184 -0.68537 0 0 0 0 0 0 0 0 9.49364 0 6.29981 0 P05089 ARGI1_HUMAN Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) ARG1 Homo sapiens (Human) adaptive immune response [GO:0002250]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; positive regulation of neutrophil mediated killing of fungus [GO:0070965]; response to nematode [GO:0009624]; urea cycle [GO:0000050] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] arginase activity [GO:0004053]; manganese ion binding [GO:0030145] KNGRISLVLGGDHSLAIGSISGHAR;TLGIKYFSMTEVTR 2 16.5 0.97687 -2.238 0 0 0 0 0 0 9.22721 0 0 10.0863 0 8.31356 P05091 ALDH2_HUMAN "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)" ALDH2 ALDM Homo sapiens (Human) alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]; nitroglycerin metabolic process [GO:0018937]; regulation of dopamine biosynthetic process [GO:1903179]; regulation of serotonin biosynthetic process [GO:1905627] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; carboxylesterase activity [GO:0106435]; electron transfer activity [GO:0009055]; NAD binding [GO:0051287]; phenylacetaldehyde dehydrogenase (NAD+) activity [GO:0008957] ILGYINTGKQEGAK;LGPALATGNVVVMK;LLNRLADLIER;VAEQTPLTALYVANLIK;VTLELGGK 5 12.4 0 3.0251 12.5942 11.8029 10.9107 9.63178 0 0 7.67772 7.87781 13.5941 0 0 0 P05093 CP17A_HUMAN "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)" CYP17A1 CYP17 S17AH Homo sapiens (Human) androgen biosynthetic process [GO:0006702]; glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025] heme binding [GO:0020037]; iron ion binding [GO:0005506]; lyase activity [GO:0016829]; oxygen binding [GO:0019825]; steroid 17-alpha-monooxygenase activity [GO:0004508] EVLRLRPVAPMLIPHK;VVFLIDSFK 2 4.9 0.91429 -0.33546 0 6.82871 0 0 0 0 0 0 0 8.04592 0 0 P05106 ITB3_HUMAN Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) ITGB3 GP3A Homo sapiens (Human) "activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to xenobiotic stimulus [GO:0071466]; embryo implantation [GO:0007566]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; maintenance of postsynaptic specialization structure [GO:0098880]; mesodermal cell differentiation [GO:0048333]; negative chemotaxis [GO:0050919]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:1900731]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of extracellular matrix organization [GO:1903053]; regulation of postsynaptic neurotransmitter receptor diffusion trapping [GO:0150054]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein localization [GO:0032880]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of serotonin uptake [GO:0051611]; regulation of trophoblast cell migration [GO:1901163]; response to activity [GO:0014823]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; tube development [GO:0035295]; wound healing [GO:0042060]; wound healing, spreading of epidermal cells [GO:0035313]" alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; alphav-beta3 integrin-vitronectin complex [GO:0071062]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; integrin alphaIIb-beta3 complex [GO:0070442]; integrin alphav-beta3 complex [GO:0034683]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; synapse [GO:0045202] cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; protein disulfide isomerase activity [GO:0003756]; protein kinase C binding [GO:0005080]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618] TTCLPMFGYK;YCECDDFSCVR 2 2.7 0.93523 -0.52075 0 4.27299 5.86009 0 0 0 0 10.7103 10.7644 0 0 0 P05107 ITB2_HUMAN "Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)" ITGB2 CD18 MFI7 Homo sapiens (Human) "amyloid-beta clearance [GO:0097242]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; endodermal cell differentiation [GO:0035987]; endothelial cell migration [GO:0043542]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; neutrophil chemotaxis [GO:0030593]; neutrophil migration [GO:1990266]; phagocytosis, engulfment [GO:0006911]; positive regulation of angiogenesis [GO:0045766]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor clustering [GO:0043113]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of cell shape [GO:0008360]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; integrin alphaL-beta2 complex [GO:0034687]; integrin alphaM-beta2 complex [GO:0034688]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] EYRRFEK;GLCFCGKCR;LGGDLLR;NCSAACPGLQLSNNPVK 4 5.2 0.97321 -2.5733 10.0067 0 0 0 10.3347 0 0 0 0 3.13981 0 0 P05108 CP11A_HUMAN "Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))" CYP11A1 CYP11A Homo sapiens (Human) C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to peptide hormone stimulus [GO:0071375]; cholesterol metabolic process [GO:0008203]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; sterol metabolic process [GO:0016125]; vitamin D metabolic process [GO:0042359] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386]; heme binding [GO:0020037]; iron ion binding [GO:0005506] ANVTEMLAGGVDTTSMTLQWHLYEMAR;DFVSVLHRR 2 6.9 0.84342 -0.052947 12.7117 10.514 0 0 0 0 0 0 0 0 0 0 P05111 INHA_HUMAN Inhibin alpha chain INHA Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; erythrocyte differentiation [GO:0030218]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell cycle [GO:0045786]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; ovarian follicle development [GO:0001541]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; inhibin B complex [GO:0043513]; inhibin-betaglycan-ActRII complex [GO:0034673]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; inhibin binding [GO:0034711]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102] LPRRHALGGFTHR 1 3.6 0.76381 0.06239 0 9.30611 0 0 0 0 0 0 0 0 0 0 P05114 HMGN1_HUMAN Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) HMGN1 HMG14 Homo sapiens (Human) "chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; post-embryonic camera-type eye morphogenesis [GO:0048597]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of development, heterochronic [GO:0040034]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV-B [GO:0010224]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; nucleosomal DNA binding [GO:0031492] VSSAEGAAK 1 9 0.92383 -0.44887 0 0 0 0 0 0 0 0 0 0 0 10.6583 P05120 PAI2_HUMAN Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor) SERPINB2 PAI2 PLANH2 Homo sapiens (Human) fibrinolysis [GO:0042730]; negative regulation of apoptotic process [GO:0043066] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] IPNLLPEGSVDGDTRMVLVNAVYFKGK 1 6.5 0.87365 -0.10833 0 0 0 0 0 0 7.97739 0 0 0 0 0 P05121 PAI1_HUMAN Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) SERPINE1 PAI1 PLANH1 Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; fibrinolysis [GO:0042730]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of signaling receptor activity [GO:0010469]; replicative senescence [GO:0090399] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peptidase inhibitor complex [GO:1904090]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; serine protease inhibitor complex [GO:0097180] protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] LPRLLVLPK;VFQQVAQASK 2 4.7 0.93351 -0.49997 0 0 0 0 0 0 9.55901 0 0 0 0 3.6311 P05129 KPCG_HUMAN Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) PRKCG PKCG Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; chemosensory behavior [GO:0007635]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phosphorylation [GO:0016310]; positive regulation of mismatch repair [GO:0032425]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of phagocytosis [GO:0050764]; regulation of response to food [GO:0032095]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to morphine [GO:0043278]; response to pain [GO:0048265]; response to psychosocial stress [GO:1990911]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; presynaptic cytosol [GO:0099523]; synaptic membrane [GO:0097060] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; zinc ion binding [GO:0008270]" CSCCEMNVHRR;VLALGGR 2 2.6 0.17737 0.33866 10.7463 0 2.8173 0 0 0 0 5.42854 0 0 0 0 P05141 ADT2_HUMAN "ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]" SLC25A5 AAC2 ANT2 Homo sapiens (Human) adaptive thermogenesis [GO:1990845]; adenine nucleotide transport [GO:0051503]; B cell differentiation [GO:0030183]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosome segregation [GO:0007059]; erythrocyte differentiation [GO:0030218]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; MMXD complex [GO:0071817]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenine nucleotide transmembrane transporter activity [GO:0000295]; adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] AAYFGIYDTAK;EQGVLSFWR;GAWSNVLR;GMLPDPK;GNLANVIR;IARDEGGK;TAVAPIER;TDAAVSFAK;TDAAVSFAKDFLAGGVAAAISK;YFPTQALNFAFK 10 31.2 0 58.743 11.8539 11.2106 11.8889 10.2668 9.99237 7.61728 11.4809 11.7101 11.6047 12.552 12.113 12.3003 P05154 IPSP_HUMAN Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5) SERPINA5 PCI PLANH3 PROCI Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; lipid transport [GO:0006869]; negative regulation of hydrolase activity [GO:0051346]; spermatogenesis [GO:0007283] acrosomal membrane [GO:0002080]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule [GO:0031091]; platelet dense tubular network [GO:0031094]; protein C inhibitor-coagulation factor V complex [GO:0097181]; protein C inhibitor-coagulation factor Xa complex [GO:0097182]; protein C inhibitor-coagulation factor XI complex [GO:0097183]; protein C inhibitor-KLK3 complex [GO:0036029]; protein C inhibitor-plasma kallikrein complex [GO:0036030]; protein C inhibitor-PLAT complex [GO:0036026]; protein C inhibitor-PLAU complex [GO:0036027]; protein C inhibitor-thrombin complex [GO:0036028]; protein C inhibitor-TMPRSS11E complex [GO:0036025]; protein C inhibitor-TMPRSS7 complex [GO:0036024]; protein-containing complex [GO:0032991] acrosin binding [GO:0032190]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; phosphatidylcholine binding [GO:0031210]; protease binding [GO:0002020]; retinoic acid binding [GO:0001972]; serine-type endopeptidase inhibitor activity [GO:0004867] AAAATGTIFTFR;FSIEGSYQLEK 2 5.7 0.77439 0.049444 0 0 0 0 0 0 0 0 0 0 8.18195 0 P05155 IC1_HUMAN Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1) SERPING1 C1IN C1NH Homo sapiens (Human) "blood circulation [GO:0008015]; blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; negative regulation of complement activation, lectin pathway [GO:0001869]" blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] serine-type endopeptidase inhibitor activity [GO:0004867] AKVGQLQLSHNLSLVILVPQNLKHR;LTLLTLLLLLLAGDR;LYHAFSAMK 3 9.8 0.96632 -1.2628 0 0 0 0 0 8.49442 8.64551 0 5.72145 0 0 0 P05156 CFAI_HUMAN Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] CFI IF Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] FYGNRFYEK;LISNCSKFYGNRFYEK;NGTAVCATNR;SLLPKLSCGVKNR;TMFICKSSWSMR;VTYTSQEDLVEK 6 10.8 0.97557 -3.3493 0 0 11.675 0 0 0 9.63423 0 10.5863 10.6997 0 0 P05160 F13B_HUMAN Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain) F13B Homo sapiens (Human) "blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; transferase complex [GO:1990234] LKCSSLRLIENGYFHPVK 1 2.7 0.5066 0.18782 0 0 0 0 0 10.2757 0 0 0 0 0 0 P05164 PERM_HUMAN Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] MPO Homo sapiens (Human) defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878] azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; secretory granule [GO:0030141] chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] GVPFFSSLR;RNGFPVALARAVSNEIVR;TITGMCNNRR;YQPMEPNPRVPLSR 4 6.8 0.73917 0.10755 0 0 0 0 0 7.5404 8.67465 0 0 0 0 0 P05164 PERM_HUMAN Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] MPO Homo sapiens (Human) defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878] azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; secretory granule [GO:0030141] chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] EASRTPQASRCQRPVLPCR;GVPFFSSLR;RNGFPVALARAVSNEIVR;YQPMEPNPRVPLSR 4 7.7 0.95506 -0.7971 0 6.06007 0 7.85798 0 0 11.7611 5.20206 0 0 0 8.11889 P05165 PCCA_HUMAN "Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" PCCA Homo sapiens (Human) branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626] catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; biotin binding [GO:0009374]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; propionyl-CoA carboxylase activity [GO:0004658] QADIRINGWAVECRVYAEDPYK 1 3 0.54685 0.18348 0 0 0 0 0 0 0 0 0 0 0 9.28737 P05186 PPBT_HUMAN "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)" ALPL Homo sapiens (Human) biomineral tissue development [GO:0031214]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; osteoblast differentiation [GO:0001649]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; calcium ion binding [GO:0005509]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462] KPFTAILYGNGPGYK 1 2.9 0.78102 0.03222 0 0 0 6.92944 0 0 0 0 0 0 0 0 P05187 PPB1_HUMAN "Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)" ALPP PLAP Homo sapiens (Human) cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] AYTVLLYGNGPGYVLK;DGARPDVTESESGSPEYR;DRKAYTVLLYGNGPGYVLK;DSTLDPSLMEMTEAALR;EAAEALGAAK;GNEVISVMNR;GNFQTIGLSAAAR;GSSIFGLAPGK;KLQPAQTAAK;LLSRNPR;LQPAQTAAK;NLVQEWLAK;QQSAVPLDEETHAGEDVAVFAR;SVGVVTTTR 14 29 0 36.283 0 0 3.4547 5.54952 7.29545 9.64044 14.0998 14.1172 13.9031 13.3807 13.3361 0 P05198 IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) EIF2S1 EIF2A Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; HRI-mediated signaling [GO:0140468]; mitophagy [GO:0000423]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to kainic acid [GO:1904373]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; synapse [GO:0045202]; translation initiation ternary complex [GO:0044207] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] LERENAEVDGDDDAEEMEAK;NECVVVIRVDKEK;RGVFNVQMEPK;RIRSINK;TEGLSVLSQAMAVIK;VVTDTDETELAR 6 24.8 0.053448 0.47376 0 10.1472 8.78963 0 9.29598 0 0 10.8012 9.87191 10.7085 10.4862 0 P05204 HMGN2_HUMAN Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2) HMGN2 HMG17 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chromatin organization [GO:0006325]; killing of cells of another organism [GO:0031640] chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723] EGNNPAENGDAK;VKDEPQR 2 21.1 0.96405 -1.1913 0 0 0 0 0 0 0 0 0 0 8.02813 0 P05305 EDN1_HUMAN Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1] EDN1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; body fluid secretion [GO:0007589]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cAMP/PKA signal transduction [GO:0141156]; canonical Wnt signaling pathway [GO:0060070]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cartilage development [GO:0051216]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to calcium ion [GO:0071277]; cellular response to fatty acid [GO:0071398]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; epithelial fluid transport [GO:0042045]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; histamine secretion [GO:0001821]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte activation [GO:0045321]; maternal process involved in parturition [GO:0060137]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; membrane depolarization [GO:0051899]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; negative regulation of blood coagulation [GO:0030195]; negative regulation of gene expression [GO:0010629]; negative regulation of hormone secretion [GO:0046888]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell fate commitment [GO:0014034]; nitric oxide transport [GO:0030185]; noradrenergic neuron differentiation [GO:0003357]; peptide hormone secretion [GO:0030072]; pharyngeal arch artery morphogenesis [GO:0061626]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase D-activating G protein-coupled receptor signaling pathway [GO:0031583]; podocyte differentiation [GO:0072112]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of odontogenesis [GO:0042482]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin biosynthetic process [GO:0001516]; protein kinase C deactivation [GO:0042313]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of pH [GO:0006885]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to activity [GO:0014823]; response to amino acid [GO:0043200]; response to amphetamine [GO:0001975]; response to dexamethasone [GO:0071548]; response to leptin [GO:0044321]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to prostaglandin F [GO:0034696]; response to salt [GO:1902074]; response to testosterone [GO:0033574]; rhythmic excitation [GO:0043179]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; superoxide anion generation [GO:0042554]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826] basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum lumen [GO:0048237]; transport vesicle [GO:0030133]; Weibel-Palade body [GO:0033093] cytokine activity [GO:0005125]; endothelin A receptor binding [GO:0031707]; endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179] ELRAEDIMEK 1 4.7 0.97777 -1.5252 0 0 0 0 0 0 0 0 10.0937 0 0 0 P05362 ICAM1_HUMAN Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) ICAM1 Homo sapiens (Human) adhesion of symbiont to host [GO:0044406]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of endothelial barrier [GO:0061028]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of leukocyte mediated cytotoxicity [GO:0001910]; regulation of ruffle assembly [GO:1900027]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; T cell antigen processing and presentation [GO:0002457]; T cell extravasation [GO:0072683] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] AKVTLNGVPAQPLGPRAQLLLK;KELLLPGNNRK;STQGEVTR;VTLNGVPAQPLGPR 4 7.7 0.98051 -1.7124 4.36737 0 0 12.8235 12.8375 4.40368 0 13.8919 0 8.89751 8.92312 11.9856 P05386 RLA1_HUMAN Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) RPLP1 RRP1 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925] protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735] AAGVNVEPFWPGLFAK 1 14 0 8.4761 0 0 0 0 0 0 11.0644 11.1542 10.1652 0 0 9.94087 P05387 RLA2_HUMAN Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) RPLP2 D11S2243E RPP2 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; cytoplasmic translational elongation [GO:0002182]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020] structural constituent of ribosome [GO:0003735] LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK;NIEDVIAQGIGK 2 39.1 0 10.179 11.2243 10.8104 11.2499 7.13186 7.35966 7.23285 0 0 0 11.5526 11.721 0 P05388 RLA0_HUMAN Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) RPLP0 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AFLADPSAFVAAAPVAAATTAAPAAAAAPAK;EESEESDEDMGFGLFD;GHLENNPALEK;GTIEILSDVQLIK;IIQLLDDYPK;TSFFQALGITTK 6 29.3 0 55.559 11.996 11.8437 12.1117 10.5736 11.5331 11.5884 11.403 13.1026 12.4179 10.661 11.0672 12.1905 P05408 7B2_HUMAN Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] SCG5 SGNE1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; regulation of hormone secretion [GO:0046883] extracellular region [GO:0005576]; nucleus [GO:0005634]; secretory granule [GO:0030141] enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; GTP binding [GO:0005525]; unfolded protein binding [GO:0051082] TDDGCLENTPDTAEFSR 1 8.1 0.78331 0.022242 0 0 0 0 0 6.52638 0 0 0 0 0 0 P05412 JUN_HUMAN Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) JUN Homo sapiens (Human) integrated stress response signaling [GO:0140467]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046]; response to endoplasmic reticulum stress [GO:0034976]; response to steroid hormone [GO:0048545]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] chromatin [GO:0000785]; euchromatin [GO:0000791]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667] "cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]" IAASKCR;NVTDEQEGFAEGFVR 2 6.6 0.9669 -1.2883 0 0 0 9.60461 10.2315 10.3953 0 0 0 0 0 0 P05451 REG1A_HUMAN Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha) REG1A PSPS PSPS1 REG Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; molecular function inhibitor activity [GO:0140678]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023] SYCYYFNEDR 1 6 0.7134 0.14464 0 0 0 6.35581 3.71578 0 0 4.55342 0 4.22774 0 3.29355 P05452 TETN_HUMAN Tetranectin (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein) CLEC3B TNA Homo sapiens (Human) bone mineralization [GO:0030282]; ossification [GO:0001503]; positive regulation of plasminogen activation [GO:0010756] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; granular component [GO:0001652]; platelet dense granule lumen [GO:0031089] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]; kringle domain binding [GO:0036143] DVVNTKMFEELK;TENCAVLSGAANGKWFDKR 2 15.3 0.93571 -0.53299 0 0 0 0 0 0 0 0 0 7.69558 6.96671 0 P05455 LA_HUMAN Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) SSB Homo sapiens (Human) histone mRNA metabolic process [GO:0008334]; IRES-dependent viral translational initiation [GO:0075522]; nuclear histone mRNA catabolic process [GO:0071045]; positive regulation of translation [GO:0045727]; protein localization to cytoplasmic stress granule [GO:1903608]; tRNA 3'-end processing [GO:0042780]; tRNA 5'-leader removal [GO:0001682]; tRNA export from nucleus [GO:0006409]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]" mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; tRNA binding [GO:0000049] DANNGNLQLR;DDYFAKK;IIEDQQESLNKWK;LTTDFNVIVEALSK;QKLEEDAEMK 5 13.2 0 3.3737 10.3567 11.4234 10.1674 9.77325 11.6373 8.71263 12.3193 12.1874 8.42059 9.87052 0 0 P05538 DQB2_HUMAN "HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)" HLA-DQB2 HLA-DXB Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] YIYNREEYGR 1 3.7 0.92155 -0.44349 0 0 0 0 0 0 0 0 10.7511 0 0 0 P05543 THBG_HUMAN Thyroxine-binding globulin (Serpin A7) (T4-binding globulin) SERPINA7 TBG Homo sapiens (Human) thyroid hormone transport [GO:0070327] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] QEINSHVEMQTKGK;TLKKWNR 2 5.1 0.98095 -1.6964 0 5.03655 0 0 0 0 0 0 0 0 0 0 P05546 HEP2_HUMAN Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) SERPIND1 HCF2 Homo sapiens (Human) blood coagulation [GO:0007596]; chemotaxis [GO:0006935] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] EVLLPKFK;QFPILLDFKTKVR;VVERWQK 3 5.6 0.97326 -2.9113 5.71573 0 0 0 0 11.437 0 0 16.9024 16.307 0 0 P05549 AP2A_HUMAN Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) TFAP2A AP2TF TFAP2 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; eyelid development in camera-type eye [GO:0061029]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; trigeminal nerve development [GO:0021559] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GLPHQLSGLDPR;GPVSLSK;MYLSNNPNSHTDNNAKSSDK;VTVAEVQR;YEDCEDR 5 12.4 0.97507 -1.4393 0 0 9.41865 0 0 0 0 0 9.84343 0 0 10.5335 P05556 ITB1_HUMAN Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 FNRB MDF2 MSK12 Homo sapiens (Human) "angiogenesis [GO:0001525]; axon extension [GO:0048675]; B cell differentiation [GO:0030183]; basement membrane organization [GO:0071711]; calcium-independent cell-matrix adhesion [GO:0007161]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular defense response [GO:0006968]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle orientation [GO:0000132]; extracellular matrix organization [GO:0030198]; formation of radial glial scaffolds [GO:0021943]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell migration [GO:0008354]; heterotypic cell-cell adhesion [GO:0034113]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; maintenance of blood-brain barrier [GO:0035633]; mesodermal cell differentiation [GO:0048333]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast fate specification [GO:0048626]; myoblast fusion [GO:0007520]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vasoconstriction [GO:0045906]; neuroblast proliferation [GO:0007405]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of wound healing [GO:0090303]; reactive gliosis [GO:0150103]; receptor internalization [GO:0031623]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse pruning [GO:1905806]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; visual learning [GO:0008542]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; integrin alpha1-beta1 complex [GO:0034665]; integrin alpha10-beta1 complex [GO:0034680]; integrin alpha11-beta1 complex [GO:0034681]; integrin alpha2-beta1 complex [GO:0034666]; integrin alpha3-beta1 complex [GO:0034667]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha5-beta1 complex [GO:0034674]; integrin alpha6-beta1 complex [GO:0034675]; integrin alpha7-beta1 complex [GO:0034677]; integrin alpha8-beta1 complex [GO:0034678]; integrin alpha9-beta1 complex [GO:0034679]; integrin alphav-beta1 complex [GO:0034682]; integrin complex [GO:0008305]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060] actin binding [GO:0003779]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; collagen binding involved in cell-matrix adhesion [GO:0098639]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]; laminin binding [GO:0043236]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618] ECVQCRAFNKGEK;FCECDNFNCDR;FQGQTCEMCQTCLGVCAEHKECVQCR;GICECGVCK;IGFGSFVEK;LKPEDITQIQPQQLVLR;LSENNIQTIFAVTEEFQPVYK;SAVTTVVNPK;SGEPQTFTLK;TVMPYISTTPAK;VGRHCECSTDEVNSEDMDAYCR 11 19.3 0 2.3616 0 0 0 0 2.9176 5.89006 10.9686 10.2984 2.47674 12.2295 3.36303 11.0183 P05771 KPCB_HUMAN Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) PRKCB PKCB PRKCB1 Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium ion transport [GO:0006816]; cellular response to carbohydrate stimulus [GO:0071322]; dibenzo-p-dioxin metabolic process [GO:0018894]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; lipoprotein transport [GO:0042953]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of D-glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of insulin secretion [GO:0032024]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; post-translational protein modification [GO:0043687]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of dopamine secretion [GO:0014059]; regulation of growth [GO:0040008]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] brush border membrane [GO:0031526]; calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; spectrin [GO:0008091] "ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; chromatin binding [GO:0003682]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone binding [GO:0042393]; histone H3T6 kinase activity [GO:0035403]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]" EHAFFRYIDWEKLER;GIIYRDLK;YIDWEKLER 3 3.4 0.97611 -1.4501 0 0 0 8.55336 0 0 0 0 0 0 0 0 P05783 K1C18_HUMAN "Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)" KRT18 CYK18 PIG46 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; extrinsic apoptotic signaling pathway [GO:0097191]; Golgi to plasma membrane protein transport [GO:0043001]; hepatocyte apoptotic process [GO:0097284]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of apoptotic process [GO:0043066]; tumor necrosis factor-mediated signaling pathway [GO:0033209] adherens junction [GO:0005912]; cell periphery [GO:0071944]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471] cadherin binding involved in cell-cell adhesion [GO:0098641]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural molecule activity [GO:0005198] AQIFANTVDNAR;AQYDELAR;ASLENSLR;GLQAQIASSGLTVEVDAPK;IIEDLRAQIFANTVDNAR;IVLQIDNAR;KGPQVRDWSHYFK;LAADDFR;LASYLDR;LEAEIATYR;LLEDGEDFNLGDALDSSNSMQTIQK;LQLETEIEALKEELLFMK;QAQEYEALLNIK;QSVENDIHGLR;QSVENDIHGLRK;SLETENR;SLGSVQAPSYGARPVSSAASVYAGAGGSGSR;STFSTNYR;TVQSLEIDLDSMR;VKYETELAMR;VVSETNDTK;YETELAMR 22 56.5 0 323.31 17.6108 17.1056 16.745 13.9505 13.7247 13.7937 14.4929 12.4255 13.9819 13.4667 13.6556 11.0475 P05787 K2C8_HUMAN "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)" KRT8 CYK8 Homo sapiens (Human) cell differentiation involved in embryonic placenta development [GO:0060706]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatocyte apoptotic process [GO:0097284]; response to hydrostatic pressure [GO:0051599]; response to other organism [GO:0051707]; sarcomere organization [GO:0045214]; tumor necrosis factor-mediated signaling pathway [GO:0033209] apicolateral plasma membrane [GO:0016327]; cell-cell junction [GO:0005911]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018] protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110] AEAESMYQIK;AEAESMYQIKYEELQSLAGK;AQYEDIANR;ASLEAAIADAEQR;DGKLVSESSDVLPK;DVDEAYMNK;DVDEAYMNKVELESR;EYQELMNVK;FASFIDK;FASFIDKVR;FLEQQNK;GGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVR;ISSSSFSR;KLLEGEESR;LEGLTDEINFLR;LESGMQNMSIHTK;LLEGEESR;LQAEIEGLK;LQAEIEGLKGQR;LSELEAALQR;LVSESSDVLPK;MLETKWSLLQQQK;QLETLGQEK;QLREYQELMNVK;QLYEEEIR;SLDMDSIIAEVK;SNMDNMFESYINNLR;SYTSGPGSR;TEISEMNR;TEMENEFVLIK;TEMENEFVLIKK;TKTEISEMNR;TQEKEQIK;TTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSR;VGSSNFR;VSTSGPR;WSLLQQQK;YEELQSLAGK 38 73.3 0 323.31 19.1923 19.1583 18.4981 15.2148 15.3333 15.206 14.2386 13.649 14.4763 16.2279 16.0023 5.06987 P05937 CALB1_HUMAN "Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)" CALB1 CAB27 Homo sapiens (Human) cochlea development [GO:0090102]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; metanephric collecting duct development [GO:0072205]; metanephric connecting tubule development [GO:0072286]; metanephric distal convoluted tubule development [GO:0072221]; metanephric part of ureteric bud development [GO:0035502]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to auditory stimulus [GO:0010996]; retina layer formation [GO:0010842]; short-term memory [GO:0007614] axon [GO:0030424]; calyx of Held [GO:0044305]; cuticular plate [GO:0032437]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; stereocilium [GO:0032420]; synapse [GO:0045202]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099567]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]; vitamin D binding [GO:0005499]; zinc ion binding [GO:0008270] KTFVDQYGQRDDGK 1 6.9 0.86451 -0.087836 0 0 10.2877 0 0 0 0 0 0 0 0 0 P05976 MYL1_HUMAN "Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2)" MYL1 Homo sapiens (Human) muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] contractile muscle fiber [GO:0043292]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307] TGDSKITLSQVGDVLR 1 8.2 0.88165 -0.1594 10.3644 0 0 0 0 0 0 0 0 0 0 0 P05981 HEPS_HUMAN Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] HPN TMPRSS1 Homo sapiens (Human) basement membrane disassembly [GO:0034769]; cochlea morphogenesis [GO:0090103]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pilomotor reflex [GO:0097195]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of thyroid hormone generation [GO:2000611]; potassium ion transmembrane transport [GO:0071805]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to thyroid hormone [GO:0097066] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] TVPCCSRPK 1 2.2 0.93525 -0.53465 0 0 0 0 0 0 0 0 0 11.2731 0 0 P05997 CO5A2_HUMAN Collagen alpha-2(V) chain COL5A2 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye morphogenesis [GO:0048592]; negative regulation of endodermal cell differentiation [GO:1903225]; ossification [GO:0001503]; skeletal system development [GO:0001501]; skin development [GO:0043588] collagen type V trimer [GO:0005588]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332] GDPGSHGR;SPDGSKKHPAR;VGDRGPAGPPGGPGDK 3 2.3 0.9798 -2.0017 0 0 0 0 0 8.3236 6.60545 0 12.4835 0 0 0 P06127 CD5_HUMAN T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) CD5 LEU1 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cell recognition [GO:0008037]; T cell costimulation [GO:0031295] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] DGWHMVCSQSWGRSSK;LSQCHELWERNSYCK;LSWYDPDFQAR 3 8.5 0.92092 -0.4401 0 3.77516 0 7.766 0 5.30885 0 0 0 0 0 0 P06132 DCUP_HUMAN Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) UROD Homo sapiens (Human) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; porphyrin-containing compound catabolic process [GO:0006787]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829]; nucleoplasm [GO:0005654] uroporphyrinogen decarboxylase activity [GO:0004853] SPEACCELTLQPLRR 1 4.1 0.51067 0.18768 3.65753 0 3.68616 0 0 0 0 0 0 0 3.08702 0 P06133 UD2B4_HUMAN UDP-glucuronosyltransferase 2B4 (UDPGT 2B4) (UGT2B4) (EC 2.4.1.17) (HLUG25) (Hyodeoxycholic acid-specific UDPGT) (UDPGTh-1) UGT2B4 UGT2B11 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210] endoplasmic reticulum membrane [GO:0005789] glucuronosyltransferase activity [GO:0015020] TVINDPLYKENAMK 1 2.7 0.92014 -0.43765 0 0 0 0 0 0 0 0 10.6398 0 0 0 P06213 INSR_HUMAN Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] INSR Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; adrenal gland development [GO:0030325]; amyloid-beta clearance [GO:0097242]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to insulin stimulus [GO:0032869]; dendritic spine maintenance [GO:0097062]; epidermis development [GO:0008544]; exocrine pancreas development [GO:0031017]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; insulin receptor signaling pathway [GO:0008286]; learning [GO:0007612]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; memory [GO:0007613]; neuron projection maintenance [GO:1990535]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor internalization [GO:0002092]; positive regulation of respiratory burst [GO:0060267]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of female gonad development [GO:2000194]; symbiont entry into host cell [GO:0046718]; transport across blood-brain barrier [GO:0150104] axon [GO:0030424]; caveola [GO:0005901]; dendrite membrane [GO:0032590]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin receptor complex [GO:0005899]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cargo receptor activity [GO:0038024]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; GTP binding [GO:0005525]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; insulin-like growth factor receptor binding [GO:0005159]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein domain specific binding [GO:0019904]; protein kinase activator activity [GO:0030295]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CVNFSFCQDLHHK;DIYETDYYR;LFFHYNPK;LLGVVSK;VCHLLEGEK;VCPTICK;VVNKESLVISGLR 7 4.8 0.98035 -2.0178 0 0 0 7.5598 11.6136 11.3402 10.6777 0 9.13804 13.633 10.0023 0 P06239 LCK_HUMAN Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) LCK Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; CD27 signaling pathway [GO:0160162]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Fc-gamma receptor signaling pathway [GO:0038094]; hemopoiesis [GO:0030097]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; leukocyte migration [GO:0050900]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein phosphorylation [GO:0006468]; regulation of lymphocyte activation [GO:0051249]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608] LGAGQFGEVWMGYYNGHTKVAVK;LIEDNEYTAR 2 6.5 0.92203 -0.44709 0 0 0 0 0 0 10.5815 0 0 0 0 0 P06307 CCKN_HUMAN Cholecystokinin (CCK) [Cleaved into: Cholecystokinin-58 (CCK58); Cholecystokinin-58 desnonopeptide ((1-49)-CCK58); Cholecystokinin-39 (CCK39); Cholecystokinin-33 (CCK33); Cholecystokinin-25 (CCK25); Cholecystokinin-18 (CCK18); Cholecystokinin-12 (CCK12); Cholecystokinin-8 (CCK8); Cholecystokinin-7 (CCK7); Cholecystokinin-5 (CCK5)] CCK Homo sapiens (Human) axonogenesis [GO:0007409]; digestion [GO:0007586]; eating behavior [GO:0042755]; neuron migration [GO:0001764]; signal transduction [GO:0007165] axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428] DYMGWMDFGR 1 8.7 0.8973 -0.24671 0 0 0 0 8.12355 0 0 0 0 0 0 0 P06396 GELS_HUMAN Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) GSN Homo sapiens (Human) "actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; amyloid fibril formation [GO:1990000]; barbed-end actin filament capping [GO:0051016]; cardiac muscle cell contraction [GO:0086003]; cell projection assembly [GO:0030031]; cellular response to type II interferon [GO:0071346]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; hepatocyte apoptotic process [GO:0097284]; negative regulation of viral entry into host cell [GO:0046597]; phagocytosis, engulfment [GO:0006911]; positive regulation of actin nucleation [GO:0051127]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein destabilization [GO:0031648]; regulation of establishment of T cell polarity [GO:1903903]; regulation of plasma membrane raft polarization [GO:1903906]; regulation of podosome assembly [GO:0071801]; regulation of receptor clustering [GO:1903909]; relaxation of cardiac muscle [GO:0055119]; renal protein absorption [GO:0097017]; response to muscle stretch [GO:0035994]; sequestering of actin monomers [GO:0042989]; striated muscle atrophy [GO:0014891]" actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; blood microparticle [GO:0072562]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcoplasm [GO:0016528]; secretory granule lumen [GO:0034774] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; myosin II binding [GO:0045159]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AGALNSNDAFVLK;AQPVQVAEGSEPDGFWEALGGK;AVEVLPK;EGGQTAPASTR;GKQANTEER;MDAHPPR;RYIETDPANR 7 10.1 0 7.3893 13.9706 0 6.10037 0 0 0 0 0 0 10.3604 11.8534 13.1686 P06400 RB_HUMAN Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) RB1 Homo sapiens (Human) "aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell proliferation [GO:0050673]; G1/S transition of mitotic cell cycle [GO:0000082]; glial cell apoptotic process [GO:0034349]; glial cell proliferation [GO:0014009]; hepatocyte apoptotic process [GO:0097284]; heterochromatin formation [GO:0031507]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; myoblast differentiation [GO:0045445]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of centromere complex assembly [GO:0090230]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]" chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Rb-E2F complex [GO:0035189]; spindle [GO:0005819]; SWI/SNF complex [GO:0016514] disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; phosphoprotein binding [GO:0051219]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625] EIDTSTK;ILVSIGESFGTSEK;INQMVCNSDRVLK;NIEISVHK;VMESMLK 5 5.3 0.98017 -2.0086 0 0 0 0 0 0 7.73769 8.815 0 0 0 0 P06454 PTMA_HUMAN "Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]" PTMA TMSA Homo sapiens (Human) DNA-templated transcription [GO:0006351]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393] AAEDDEDDDVDTK;AAEDDEDDDVDTKK;EVVEEAENGR;SDAAVDTSSEITTK 4 34.2 0 141.39 11.5979 12.7092 11.9299 0 11.9677 12.0183 12.6396 8.75949 0 13.767 14.2117 13.4402 P06493 CDK1_HUMAN Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) CDK1 CDC2 CDC28A CDKN1 P34CDC2 Homo sapiens (Human) animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic cyclic compound [GO:0071407]; centrosome cycle [GO:0007098]; chromosome condensation [GO:0030261]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; epithelial cell differentiation [GO:0030855]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA replication [GO:0045740]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; pronuclear fusion [GO:0007344]; protein deubiquitination [GO:0016579]; protein localization to kinetochore [GO:0034501]; protein-containing complex assembly [GO:0065003]; regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902423]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; regulation of Schwann cell differentiation [GO:0014038]; response to activity [GO:0014823]; response to amine [GO:0014075]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to ethanol [GO:0045471]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; rhythmic process [GO:0048511]; ventricular cardiac muscle cell development [GO:0055015] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cyclin A1-CDK1 complex [GO:0097121]; cyclin A2-CDK1 complex [GO:0097122]; cyclin B1-CDK1 complex [GO:0097125]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]" ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin binding [GO:0030332]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; Hsp70 protein binding [GO:0030544]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833]; virus receptor activity [GO:0001618] IGEGTYGVVYK;LADFGLAR;NLDENGLDLLSK;SPEVLLGSAR 4 13.8 0 2.6448 11.1159 12.3446 12.5718 0 0 0 0 0 0 0 0 0 P06576 ATPB_HUMAN "ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)" ATP5F1B ATP5B ATPMB ATPSB Homo sapiens (Human) angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; cellular response to interleukin-7 [GO:0098761]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; osteoblast differentiation [GO:0001649]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453] "cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; proton-transporting ATP synthase, catalytic core [GO:0045267]" "angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" AGAATGR;AIAELGIYPAVDPLDSTSR;FTQAGSEVSALLGR;IGLFGGAGVGK;IMDPNIVGSEHYDVAR;IMNVIGEPIDERGPIK;IPSAVGYQPTLATDMGTMQER;IPVGPETLGR;TIAMDGTEGLVR;TVLIMELINNVAK;VALVYGQMNEPPGAR;VLDSGAPIKIPVGPETLGR;VVDLLAPYAK 13 32.7 0 66.769 14.8361 14.5239 14.7245 11.9182 12.5121 12.2852 14.7475 14.6852 14.6996 13.1597 13.1321 14.6049 P06681 CO2_HUMAN Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment] C2 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to thyroid hormone [GO:0097066]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] AGHCPNPGISLGAVR;EILNINQKRNDYLDIYAIGVGK;VNVGDPK 3 8.2 0.71557 0.14014 11.0586 9.60001 8.68349 6.75862 7.9514 0 10.9716 10.7595 10.6951 12.3566 0 13.0542 P06703 S10A6_HUMAN Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6) S100A6 CACY Homo sapiens (Human) axonogenesis [GO:0007409]; positive regulation of fibroblast proliferation [GO:0048146]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; monoatomic ion transmembrane transporter activity [GO:0015075]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tropomyosin binding [GO:0005523]; zinc ion binding [GO:0008270] ELTIGSK;LMEDLDR;LQDAEIAR;YSGREGDK 4 33.3 0.88857 -0.18412 0 0 0 10.3355 11.4571 0 11.9171 0 9.55859 13.1053 11.7913 0 P06727 APOA4_HUMAN Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4) APOA4 Homo sapiens (Human) acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron assembly [GO:0034378]; chylomicron remodeling [GO:0034371]; high-density lipoprotein particle remodeling [GO:0034375]; hydrogen peroxide catabolic process [GO:0042744]; innate immune response in mucosa [GO:0002227]; leukocyte cell-cell adhesion [GO:0007159]; lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; negative regulation of plasma lipoprotein oxidation [GO:0034445]; peripheral nervous system axon regeneration [GO:0014012]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of triglyceride catabolic process [GO:0010898]; protein-lipid complex assembly [GO:0065005]; regulation of cholesterol transport [GO:0032374]; regulation of intestinal cholesterol absorption [GO:0030300]; removal of superoxide radicals [GO:0019430]; response to lipid hydroperoxide [GO:0006982]; response to stilbenoid [GO:0035634]; response to triglyceride [GO:0034014]; reverse cholesterol transport [GO:0043691]; very-low-density lipoprotein particle remodeling [GO:0034372] blood microparticle [GO:0072562]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; synapse [GO:0045202]; very-low-density lipoprotein particle [GO:0034361] antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803] AKIDQNVEELK;ELQQRLEPYADQLRTQVSTQAEQLR;LTPYADEFK 3 11.4 0.9754 -3.574 0 0 0 0 0 10.9443 0 0 0 0 0 0 P06729 CD2_HUMAN T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) CD2 SRBC Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; membrane raft polarization [GO:0001766]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell activation [GO:0030887]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell differentiation [GO:0045580]; T cell activation [GO:0042110] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] VITHKWTTSLSAK 1 3.7 0.83028 -0.024841 0 0 0 0 0 10.1094 12.3893 4.12317 0 0 0 0 P06730 IF4E_HUMAN Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) EIF4E EIF4EL1 EIF4F Homo sapiens (Human) "behavioral fear response [GO:0001662]; cellular response to dexamethasone stimulus [GO:0071549]; G1/S transition of mitotic cell cycle [GO:0000082]; mRNA export from nucleus [GO:0006406]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; stem cell population maintenance [GO:0019827]; translational initiation [GO:0006413]" chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; RISC complex [GO:0016442] DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; eukaryotic initiation factor 4G binding [GO:0031370]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation initiation factor activity [GO:0003743] RSDLDRFWLETR;WDLAMLPR 2 8.1 0.98086 -1.7493 0 0 0 11.0173 10.9869 0 0 0 0 10.4877 10.2586 11.6453 P06731 CEAM5_HUMAN Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] GPI anchor binding [GO:0034235]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] LQLSNDNR;NDTASYK 2 2.1 0.96726 -1.2906 0 0 0 0 0 0 0 0 0 0 11.9425 0 P06732 KCRM_HUMAN Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) CKM CKMM Homo sapiens (Human) phosphocreatine biosynthetic process [GO:0046314] cytosol [GO:0005829]; extracellular space [GO:0005615] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] GIWHNDNK;HPKFEEILTRLR 2 5.2 0.87064 -0.095908 3.74782 0 0 0 0 0 0 0 0 0 0 0 P06733 ENOA_HUMAN Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) ENO1 ENO1L1 MBPB1 MPB1 Homo sapiens (Human) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of muscle contraction [GO:0045933]; positive regulation of plasminogen activation [GO:0010756]; response to virus [GO:0009615] cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; M band [GO:0031430]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]" AAVPSGASTGIYEALELR;AAVPSGASTGIYEALELRDNDK;AAVPSGASTGIYEALELRDNDKTR;AGYTDKVVIGMDVAASEFFR;AVEHINK;DATNVGDEGGFAPNILENK;DATNVGDEGGFAPNILENKEGLELLK;EGLELLK;FTASAGIQVVGDDLTVTNPK;GNPTVEVDLFTSK;HIADLAGNSEVILPVPAFNVINGGSHAGNK;IEEELGSK;IGAEVYHNLK;KLNVTEQEK;LAMQEFMILPVGAANFR;LAQANGWGVMVSHR;LMIEMDGTENK;LNVTEQEK;NFRNPLAK;SCNCLLLK;SGETEDTFIADLVVGLCTGQIK;TIAPALVSK;VNQIGSVTESLQACK;YDLDFKSPDDPSR;YISPDQLADLYK 25 68.2 0 241.58 16.1853 16.0581 16.0648 12.7634 12.9746 13.1212 16.543 16.3118 16.3532 15.413 16.0843 15.7012 P06737 PYGL_HUMAN "Glycogen phosphorylase, liver form (EC 2.4.1.1)" PYGL Homo sapiens (Human) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; necroptotic process [GO:0070266]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] AMP binding [GO:0016208]; ATP binding [GO:0005524]; bile acid binding [GO:0032052]; D-glucose binding [GO:0005536]; glycogen phosphorylase activity [GO:0008184]; identical protein binding [GO:0042802]; maltodextrin phosphorylase activity [GO:0031220]; purine nucleobase binding [GO:0002060]; pyridoxal phosphate binding [GO:0030170]; vitamin binding [GO:0019842] DLSQLTK;ISLSNESNK;LKQEYFVVAATLQDIIRR;QENKLKFSQFLETEYK;QISIRGIVGVENVAELK;TNGITPR;VIFLENYR 7 9.7 0.92339 -0.44904 9.03703 0 0 0 0 0 0 8.51523 9.69841 0 12.8966 0 P06744 G6PI_HUMAN Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) GPI Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; erythrocyte homeostasis [GO:0034101]; fructose 6-phosphate metabolic process [GO:0006002]; GDP-mannose biosynthetic process from glucose [GO:0141199]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; hemostasis [GO:0007599]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; learning or memory [GO:0007611]; mesoderm formation [GO:0001707]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574] ciliary membrane [GO:0060170]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347]; growth factor activity [GO:0008083]; monosaccharide binding [GO:0048029]; ubiquitin protein ligase binding [GO:0031625] AVLHVALR;FAAYFQQGDMESNGK;GKSTEEAR;HFVALSTNTTK;INYTEGR;MLVDLAK;NLVTEDVMR;SNTPILVDGK;SNTPILVDGKDVMPEVNK;SPAMAALTRDPQFQKLQQWYR;SPEDLER;TLAQLNPESSLFIIASK;VFEGNRPTNSIVFTK;VWYVSNIDGTHIAK 14 27.6 0 117.36 11.6964 13.5766 13.0012 9.87064 8.37173 8.14343 15.0504 15.5241 13.5811 13.9596 13.3647 11.5869 P06746 DPOLB_HUMAN DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) POLB Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; homeostasis of number of cells [GO:0048872]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lymph node development [GO:0048535]; neuron apoptotic process [GO:0051402]; pyrimidine dimer repair [GO:0006290]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to hyperoxia [GO:0055093]; salivary gland morphogenesis [GO:0007435]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spleen development [GO:0048536]" cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] DIFDYIQWK;FVDEGIKTLEDLRK;IDIRLIPK 3 9.3 0.97824 -1.9248 0 0 0 10.2499 0 10.1273 0 0 10.6845 0 0 0 P06748 NPM_HUMAN Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) NPM1 NPM Homo sapiens (Human) cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of centriole replication [GO:0046599]; regulation of centrosome duplication [GO:0010824]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; regulation of mRNA stability involved in cellular response to UV [GO:1902629]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome assembly [GO:0042255]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; granular component [GO:0001652]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; spindle pole centrosome [GO:0031616] chromatin binding [GO:0003682]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; molecular adaptor activity [GO:0060090]; NF-kappaB binding [GO:0051059]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082] GPSSVEDIK;GPSSVEDIKAKMQASIEK;LLSISGK;MQASIEK;MSVQPTVSLGGFEITPPVVLR;VDNDENEHQLSLR;VTLATLK 7 22.4 0 53.821 15.651 14.7557 15.2899 11.3119 12.3353 12.6362 13.4752 13.5233 14.0806 14.3073 14.2397 12.731 P06753 TPM3_HUMAN Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) TPM3 Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725] actin filament binding [GO:0051015] AADAEAEVASLNR;EAETRAEFAER;EAKHIAEEADRK;HIAEEADR;IQLVEEELDR;LATALQK;MELQEIQLK;YSQKEDK 8 24.2 0 16.004 10.7816 0 0 0 0 0 0 0 0 11.1192 0 0 P06753 TPM3_HUMAN Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) TPM3 Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725] actin filament binding [GO:0051015] AELAESR;AGITTIEAVK;AGITTIEAVKR;EAETRAEFAER;EAKHIAEEADRK;EMDEQIR;EQAEAEVASLNR;HIAEEADR;IQLVEEELDR;KIQVLQQQADDAEER;LATALQK;LMDQNLK;MELQEIQLK;MLDQTLLDLNEM;TIDDLEDKLK;YSQKEDK 16 55.2 0 104.59 14.1634 14.3004 13.9445 9.97928 10.0065 13.414 10.58 12.8575 12.619 12.7753 13.0538 11.2352 P06753 TPM3_HUMAN Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) TPM3 Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725] actin filament binding [GO:0051015] AELAESR;AGITTIEAVK;AGITTIEAVKR;EAETRAEFAER;EAKHIAEEADRK;EMDEQIR;EQAEAEVASLNR;HIAEEADR;IQLVEEELDR;KIQVLQQQADDAEER;LATALQK;LEKTIDDLEER;LMDQNLK;MELQEIQLK;YSQKEDK 15 51 0.94542 -0.64345 0 0 0 0 0 0 0 0 0 0 11.343 0 P06756 ITAV_HUMAN Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] ITGAV MSK8 VNRA VTNR Homo sapiens (Human) "angiogenesis [GO:0001525]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; calcium ion transmembrane transport [GO:0070588]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; endodermal cell differentiation [GO:0035987]; entry into host cell by a symbiont-containing vacuole [GO:0085017]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of entry of bacterium into host cell [GO:2000536]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of phagocytosis [GO:0050764]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; transforming growth factor beta production [GO:0071604]; vasculogenesis [GO:0001570]; wound healing, spreading of epidermal cells [GO:0035313]" alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; integrin alphav-beta1 complex [GO:0034682]; integrin alphav-beta3 complex [GO:0034683]; integrin alphav-beta5 complex [GO:0034684]; integrin alphav-beta6 complex [GO:0034685]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579] coreceptor activity [GO:0015026]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; opsonin binding [GO:0001846]; protease binding [GO:0002020]; protein kinase C binding [GO:0005080]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; voltage-gated calcium channel activity [GO:0005245] MFLLVGAPK;QAHILLDCGEDNVCKPK;TEMKQER;TVEYAPCR 4 3.9 0.88822 -0.18879 0 0 0 0 0 0 10.889 0 0 0 10.5795 9.61305 P06850 CRF_HUMAN Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) CRH Homo sapiens (Human) "adrenal gland development [GO:0030325]; associative learning [GO:0008306]; cellular response to cocaine [GO:0071314]; cellular response to dexamethasone stimulus [GO:0071549]; chemical synaptic transmission [GO:0007268]; diterpenoid metabolic process [GO:0016101]; female pregnancy [GO:0007565]; glucocorticoid biosynthetic process [GO:0006704]; hormone-mediated apoptotic signaling pathway [GO:0008628]; hypothalamus development [GO:0021854]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; lung development [GO:0030324]; monoatomic ion homeostasis [GO:0050801]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gene expression [GO:0010629]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of luteinizing hormone secretion [GO:0033685]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuron apoptotic process [GO:0051402]; parturition [GO:0007567]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of corticosterone secretion [GO:2000854]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of digestive system process [GO:0060456]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of NMDA receptor activity [GO:2000310]; regulation of serotonin secretion [GO:0014062]; response to aldosterone [GO:1904044]; response to corticosterone [GO:0051412]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to immobilization stress [GO:0035902]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle lumen [GO:0099013]; perikaryon [GO:0043204]; synapse [GO:0045202]; varicosity [GO:0043196] corticotropin-releasing hormone activity [GO:0017045]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102] ALLSRGPVPGAR;RSLDSPAALAERGAR 2 13.8 0.97635 -1.4511 0 0 0 0 0 0 0 0 9.07526 9.41756 0 0 P06858 LIPL_HUMAN Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32) LPL LIPD Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; high-density lipoprotein particle remodeling [GO:0034375]; low-density lipoprotein particle mediated signaling [GO:0055096]; phospholipid metabolic process [GO:0006644]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of tumor necrosis factor production [GO:0032760]; response to bacterium [GO:0009617]; response to glucose [GO:0009749]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372] catalytic complex [GO:1902494]; cell surface [GO:0009986]; chylomicron [GO:0042627]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; triacylglycerol lipase activity [GO:0004806] AGETQKK;LVAALYK 2 2.9 0.41123 0.20429 0 10.3793 0 8.01408 0 0 8.69846 0 0 0 0 0 P06865 HEXA_HUMAN Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) HEXA Homo sapiens (Human) adult walking behavior [GO:0007628]; carbohydrate metabolic process [GO:0005975]; cell morphogenesis involved in neuron differentiation [GO:0048667]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; lipid storage [GO:0019915]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; myelination [GO:0042552]; N-glycan processing [GO:0006491]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; sensory perception of sound [GO:0007605]; sexual reproduction [GO:0019953]; skeletal system development [GO:0001501] azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; protein heterodimerization activity [GO:0046982] GLETFSQLVWK;ISYGPDWK;LWPRAGAVAER;LWSNKLTSDLTFAYERLSHFR 4 9.6 0.96417 -1.1796 0 11.1279 0 0 0 0 0 0 0 0 0 11.0682 P07093 GDN_HUMAN Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2) SERPINE2 PI7 PN1 Homo sapiens (Human) "cell differentiation [GO:0030154]; cerebellar granular layer morphogenesis [GO:0021683]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; innervation [GO:0060384]; long-term synaptic potentiation [GO:0060291]; mating plug formation [GO:0042628]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of proteolysis [GO:0045861]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of sodium ion transport [GO:0010766]; platelet activation [GO:0030168]; positive regulation of astrocyte differentiation [GO:0048711]; protein catabolic process [GO:0030163]; regulation of cell migration [GO:0030334]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of timing of cell differentiation [GO:0048505]; secretion by cell [GO:0032940]; secretory granule organization [GO:0033363]; seminal vesicle epithelium development [GO:0061108]" collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; neuromuscular junction [GO:0031594]; platelet alpha granule [GO:0031091] glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] GLWKSRFQPENTK 1 3.3 0.96135 -1.0619 0 0 0 0 0 0 0 0 10.8474 0 0 0 P07098 LIPF_HUMAN Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) LIPF Homo sapiens (Human) lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108]; triglyceride metabolic process [GO:0006641] extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; malate dehydrogenase activity [GO:0016615]; triacylglycerol lipase activity [GO:0004806] FSNANSR;FSNANSRSK 2 2.4 0.70223 0.16033 11.7579 0 12.6588 0 0 0 0 0 11.0391 0 8.29398 0 P07099 HYEP_HUMAN Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) EPHX1 EPHX EPOX Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; epoxide metabolic process [GO:0097176]; hydrocarbon catabolic process [GO:0120253]; response to polycyclic arene [GO:1903165]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]; oxysterol binding [GO:0008142] DVELLYPVK;FLSVLERQ;GFNSVATAR;IIPLLTDPK;LISYSYMVR;NEFDWKK;YLEDGGLER 7 13.2 0.33822 0.24054 0 0 0 0 0 0 13.3176 10.7251 11.2606 11.39 10.5085 0 P07108 ACBP_HUMAN Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) DBI Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; negative regulation of protein lipidation [GO:1903060]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of phospholipid transport [GO:2001140] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear endoplasmic reticulum [GO:0097038]; protein-lipid complex [GO:0032994] benzodiazepine receptor binding [GO:0030156]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA binding [GO:0036042] MPAFAEFEKAAEEVR 1 17 0.91577 -0.43253 9.85276 0 0 0 0 0 0 0 0 0 0 0 P07108 ACBP_HUMAN Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) DBI Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; negative regulation of protein lipidation [GO:1903060]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of phospholipid transport [GO:2001140] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear endoplasmic reticulum [GO:0097038]; protein-lipid complex [GO:0032994] benzodiazepine receptor binding [GO:0030156]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA binding [GO:0036042] ELGGQGKYGAGCSECGTRR;SQHRAGR;YGAGCSECGTRRIAAR 3 23.3 0.98064 -1.7931 13.2508 13.2483 13.5164 0 10.8753 0 0 5.4692 0 6.03267 11.5554 0 P07148 FABPL_HUMAN "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP)" FABP1 FABPL Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of fatty acid beta-oxidation [GO:0032000]; response to vitamin B3 [GO:0033552] apical cortex [GO:0045179]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; protein-containing complex [GO:0032991] antioxidant activity [GO:0016209]; bile acid binding [GO:0032052]; chromatin binding [GO:0003682]; fatty acid binding [GO:0005504]; heterocyclic compound binding [GO:1901363]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; oleic acid binding [GO:0070538]; phospholipid binding [GO:0005543] AIGLPEELIQK;GVSEIVQNGK;SVTELNGDIITNTMTLGDIVFKRISK 3 37 0.053541 0.47448 0 13.0799 12.0481 0 0 0 0 9.7191 0 0 0 0 P07195 LDHB_HUMAN L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) LDHB Homo sapiens (Human) lactate metabolic process [GO:0006089]; NAD metabolic process [GO:0019674]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204] identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-lactate dehydrogenase activity [GO:0004459]; NAD binding [GO:0051287] DYSVTANSK;FIIPQIVK;GLTSVINQK;IHPVSTMVK;IVADKDYSVTANSK;IVADKDYSVTANSKIVVVTAGVR;IVVVTAGVR;LIAPVAEEEATVPNNK;LKDDEVAQLK;MVVESAYEVIK;SADTLWDIQK;SLADELALVDVLEDK;VIGSGCNLDSAR 13 36.8 0 28.859 15.483 15.7494 15.6136 13.1461 12.5982 11.566 0 14.3107 13.9854 12.5496 12.8458 11.3162 P07196 NFL_HUMAN Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) NEFL NF68 NFL Homo sapiens (Human) anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intermediate filament organization [GO:0045109]; intermediate filament polymerization or depolymerization [GO:0045105]; locomotion [GO:0040011]; microtubule cytoskeleton organization [GO:0000226]; motor neuron apoptotic process [GO:0097049]; negative regulation of motor neuron apoptotic process [GO:2000672]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axonogenesis [GO:0050772]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein polymerization [GO:0051258]; regulation of axon diameter [GO:0031133]; regulation of synapse maturation [GO:0090128]; response to acrylamide [GO:1903937]; response to corticosterone [GO:0051412]; response to peptide hormone [GO:0043434]; response to sodium arsenite [GO:1903935]; response to toxic substance [GO:0009636]; retrograde axonal transport [GO:0008090]; spinal cord development [GO:0021510] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cholinergic synapse [GO:0098981]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; neuromuscular junction [GO:0031594]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; presynaptic intermediate filament cytoskeleton [GO:0099182]; Schaffer collateral - CA1 synapse [GO:0098685] identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184] AEEAKDEPPSEGEAEEEEK;EYQDLLNVK;KVEGAGEEQAAK;MSSFSYEPYYSTSYK;NMQNAEEWFKSRFTVLTESAAK;QALQGER;VHISSVR 7 16.8 0.98033 -1.6684 0 0 0 0 0 0 0 0 7.01436 9.46779 0 8.65982 P07197 NFM_HUMAN Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) NEFM NEF3 NFM Homo sapiens (Human) neurofilament bundle assembly [GO:0033693] axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160] microtubule binding [GO:0008017]; structural constituent of cytoskeleton [GO:0005200] AGGEGGSEEEGSDKGAKGSR;EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK;EIEAEIQALRQK;EYQDLLNVK;FVEEIIEETK;HLREYQDLLNVK 6 9.6 0.95299 -0.73503 7.46442 0 0 0 0 0 0 0 0 0 4.62982 10.4716 P07199 CENPB_HUMAN Major centromere autoantigen B (Centromere protein B) (CENP-B) CENPB Homo sapiens (Human) "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; satellite DNA binding [GO:0003696]; sequence-specific DNA binding [GO:0043565] HGVVSCSGVARARAR 1 2.5 0.6825 0.16541 0 4.88401 0 0 0 0 9.65146 0 0 0 0 0 P07202 PERT_HUMAN Thyroid peroxidase (TPO) (EC 1.11.1.8) TPO Homo sapiens (Human) embryonic hemopoiesis [GO:0035162]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601] AAAQDSEQESAGMEGR 1 1.7 0.87333 -0.11586 0 0 0 0 0 0 0 0 0 0 8.09228 0 P07205 PGK2_HUMAN "Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific)" PGK2 PGKB Homo sapiens (Human) canonical glycolysis [GO:0061621]; flagellated sperm motility [GO:0030317]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686] ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] ASGFLMK;LGDVYVNDAFGTAHR;VDFNVPMK 3 7.2 0.9412 -0.5936 0 0 0 0 0 0 0 0 8.46569 0 0 0 P07225 PROS_HUMAN Vitamin K-dependent protein S PROS1 PROS Homo sapiens (Human) blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; endopeptidase inhibitor activity [GO:0004866] EIIQEKQNK;VYFAGFPRK 2 2.7 0.88097 -0.14693 7.2765 7.14649 0 6.42593 0 0 0 0 0 0 7.03925 0 P07237 PDIA1_HUMAN Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) P4HB ERBA2L PDI PDIA1 PO4DB Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; cellular response to interleukin-7 [GO:0098761]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of cell adhesion [GO:0045785]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of viral entry into host cell [GO:0046598]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; procollagen-proline 4-dioxygenase complex [GO:0016222]; protein-containing complex [GO:0032991] actin binding [GO:0003779]; enzyme binding [GO:0019899]; integrin binding [GO:0005178]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; protein heterodimerization activity [GO:0046982]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thiol oxidase activity [GO:0016972] ALAPEYAK;EADDIVNWLK;FFPASADR;ILEFFGLK;LITLEEEMTK;LKAEGSEIR;MDSTANEVEAVK;QFLQAAEAIDDIPFGITSNSDVFSK;SVSDYDGK;SVSDYDGKLSNFK;TAAESFK;TVIDYNGER;VDATEESDLAQQYGVR 13 26.6 0 40.049 10.4412 12.8438 0 8.73556 7.81673 7.41236 10.5479 12.067 11.765 13.6956 14.0464 13.8332 P07288 KLK3_HUMAN Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase) KLK3 APS Homo sapiens (Human) negative regulation of angiogenesis [GO:0016525]; positive regulation of antibacterial peptide production [GO:0002803]; protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141] "endopeptidase activity [GO:0004175]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]" VTKFMLCAGR 1 3.8 0.88866 -0.18435 0 11.0477 0 0 0 0 0 0 0 0 0 0 P07305 H10_HUMAN "Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]" H1-0 H1F0 H1FV Homo sapiens (Human) chromosome condensation [GO:0030261]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of transcription regulatory region DNA binding [GO:2000679] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] AKPVKPK;GVGASGSFR;KPKTVKAKPVK;LVTTGVLK;VGENADSQIK 5 23.2 0.8729 -0.11236 0 9.32888 0 0 0 0 4.81311 0 6.22512 0 0 0 P07306 ASGR1_HUMAN Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) ASGR1 CLEC4H1 Homo sapiens (Human) immune response [GO:0006955]; receptor-mediated endocytosis [GO:0006898] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] asialoglycoprotein receptor activity [GO:0004873]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187] TCCPVNWVEHERSCYWFSR 1 6.5 0.91934 -0.43838 0 0 0 0 0 0 0 0 0 0 0 7.88044 P07311 ACYP1_HUMAN "Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)" ACYP1 ACYPE Homo sapiens (Human) phosphate-containing compound metabolic process [GO:0006796] acylphosphatase activity [GO:0003998] VILKLDYSDFQIVK 1 14.1 0.91891 -0.43663 0 0 0 0 0 0 0 0 0 12.625 0 0 P07316 CRGB_HUMAN Gamma-crystallin B (Gamma-B-crystallin) (Gamma-crystallin 1-2) CRYGB CRYG2 Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; visual perception [GO:0007601] cytoplasm [GO:0005737]; nucleus [GO:0005634] structural constituent of eye lens [GO:0005212] FLDWGAPNAK;ITFYEDR 2 9.7 0.95264 -0.6789 0 0 10.7459 0 0 0 0 0 0 0 8.83577 0 P07332 FES_HUMAN Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) FES FPS Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; cellular response to vitamin D [GO:0071305]; centrosome cycle [GO:0007098]; chemotaxis [GO:0006935]; microtubule bundle formation [GO:0001578]; myoblast proliferation [GO:0051450]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of mast cell degranulation [GO:0043304]; regulation of vesicle-mediated transport [GO:0060627] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; immunoglobulin receptor binding [GO:0034987]; microtubule binding [GO:0008017]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol binding [GO:0035091]; protein tyrosine kinase activity [GO:0004713] GNFGEVFSGR;NCLVTEKNVLK 2 2.6 0.98049 -1.806 0 0 0 0 0 10.1037 0 0 0 0 8.24707 0 P07333 CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) CSF1R FMS Homo sapiens (Human) axon guidance [GO:0007411]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell junction maintenance [GO:0045217]; cellular response to cytokine stimulus [GO:0071345]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cytokine-mediated signaling pathway [GO:0019221]; forebrain neuron differentiation [GO:0021879]; hemopoiesis [GO:0030097]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; mammary gland duct morphogenesis [GO:0060603]; microglial cell proliferation [GO:0061518]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation by host of viral process [GO:0044794]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of cell shape [GO:0008360]; regulation of macrophage migration [GO:1905521]; regulation of MAPK cascade [GO:0043408]; response to ischemia [GO:0002931]; ruffle organization [GO:0031529]; signal transduction [GO:0007165] cell surface [GO:0009986]; CSF1-CSF1R complex [GO:1990682]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine binding [GO:0019955]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] VMSISIR 1 0.7 0.93392 -0.51514 0 0 0 0 0 0 11.1988 0 0 0 0 0 P07339 CATD_HUMAN Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] CTSD CPSD Homo sapiens (Human) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagosome assembly [GO:0000045]; execution phase of apoptosis [GO:0097194]; insulin catabolic process [GO:1901143]; insulin receptor recycling [GO:0038020]; lipoprotein catabolic process [GO:0042159]; positive regulation of apoptotic process [GO:0043065]; proteolysis [GO:0006508]; regulation of establishment of protein localization [GO:0070201] collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] aspartic-type endopeptidase activity [GO:0004190]; aspartic-type peptidase activity [GO:0070001]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233] ISVNNVLPVFDNLMQQK;LSPEDYTLK;LSPEDYTLKVSQAGK;VSTLPAITLK 4 10.2 0.73586 0.11149 0 0 0 10.6647 0 0 0 0 10.8954 11.2208 12.2129 10.9535 P07355 ANXA2_HUMAN Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 ANX2L4 CAL1H LPC2D Homo sapiens (Human) angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; epithelial cell apoptotic process [GO:1904019]; fibrinolysis [GO:0042730]; lung development [GO:0030324]; membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of receptor internalization [GO:0002091]; osteoclast development [GO:0036035]; positive regulation of exocytosis [GO:0045921]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of low-density lipoprotein particle receptor binding [GO:1905597]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of receptor recycling [GO:0001921]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vacuole organization [GO:0044090]; positive regulation of vesicle fusion [GO:0031340]; regulation of neurogenesis [GO:0050767]; response to activity [GO:0014823]; vesicle budding from membrane [GO:0006900] adherens junction [GO:0005912]; AnxA2-p11 complex [GO:1990665]; azurophil granule lumen [GO:0035578]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; myelin sheath adaxonal region [GO:0035749]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; PCSK9-AnxA2 complex [GO:1990667]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575]; sarcolemma [GO:0042383]; Schmidt-Lanterman incisure [GO:0043220]; vesicle [GO:0031982]; vesicle membrane [GO:0012506] "cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; protease binding [GO:0002020]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; serine-type endopeptidase inhibitor activity [GO:0004867]" AEDGSVIDYELIDQDAR;AYTNFDAER;AYTNFDAERDALNIETAIK;DALNIETAIK;DIISDTSGDFR;DIISDTSGDFRK;DLYDAGVK;ELASALK;GVDEVTIVNILTNR;KGTDVPK;LMVALAK;LSLEGDHSTPPSAYGSVK;LYDSMKGK;QDIAFAYQR;RAEDGSVIDYELIDQDAR;SEVDMLK;SLYYYIQQDTK;SVPHLQK;SYSPYDMLESIR;SYSPYDMLESIRK;TDLEKDIISDTSGDFRK;TNQELQEINR;TPAQYDASELK;WISIMTER 24 58.7 0 323.31 14.2738 15.3372 14.9757 12.9929 11.4101 12.036 15.2117 15.6692 15.7673 15.8358 16.1773 15.1417 P07357 CO8A_HUMAN Complement component C8 alpha chain (Complement component 8 subunit alpha) C8A Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] complement binding [GO:0001848]; protein-containing complex binding [GO:0044877] YRHRSLLQPNK 1 1.9 0.97957 -1.5402 0 0 0 0 0 12.7071 0 0 0 0 0 0 P07384 CAN1_HUMAN Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) CAPN1 CANPL1 PIG30 Homo sapiens (Human) mammary gland involution [GO:0060056]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]; regulation of catalytic activity [GO:0050790]; regulation of macroautophagy [GO:0016241]; self proteolysis [GO:0097264] calpain complex [GO:0110158]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233] DLGPNSSKTYGIK;GHAYSVTGAKQVNYR;GSLLGCSIDISSVLDMEAITFK;VKMEDGEFWMSFRDFMR 4 9.4 0.95225 -0.68487 0 0 0 9.30198 9.01179 0 0 0 0 6.82833 0 0 P07437 TBB5_HUMAN Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 OK/SW-cl.56 Homo sapiens (Human) cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; odontoblast differentiation [GO:0071895]; regulation of synapse organization [GO:0050807]; spindle assembly [GO:0051225] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] AILVDLEPGTMDSVR;ALTVPELTQQVFDAK;EVDEQMLNVQNK;FPGQLNADLRK;GHYTEGAELVDSVLDVVR;IMNTFSVVPSPK;IREEYPDR;IREEYPDRIMNTFSVVPSPK;ISEQFTAMFR;ISVYYNEATGGK;LAVNMVPFPR;LHFFMPGFAPLTSR;MAVTFIGNSTAIQELFKR;NSSYFVEWIPNNVK;SGPFGQIFRPDNFVFGQSGAGNNWAK;TAVCDIPPR;YLTVAAVFR 17 48 0 69.632 15.9529 14.8029 14.8148 12.7218 11.0995 12.3833 14.3198 14.3943 14.3094 13.1613 12.911 15.4091 P07438 MT1B_HUMAN Metallothionein-1B (MT-1B) (Metallothionein-IB) (MT-IB) MT1B MT1Q Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] CCCSCCPVGCAKCAQGCVCKGSSEK;MDPNCSCTTGGSCACAGSCK;MDPNCSCTTGGSCACAGSCKCK 3 77 0.88333 -0.17382 6.6241 0 0 6.84071 7.16742 0 0 0 0 0 3.6153 0 P07451 CAH3_HUMAN Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) CA3 Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829] carbonate dehydratase activity [GO:0004089]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] EPMTVSSDQMAKLR;HDPSLQPWSVSYDGGSAKTILNNGK 2 15 0.95493 -0.89972 0 0 0 0 0 5.43513 0 0 0 9.14807 0 0 P07476 INVO_HUMAN Involucrin IVL Homo sapiens (Human) isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [GO:0018153]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; response to UV-B [GO:0010224] centrosome [GO:0005813]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604] AENPEQQLKQEKTQR 1 2.6 0.84833 -0.077168 8.28808 0 0 0 0 0 0 0 0 0 0 0 P07478 TRY2_HUMAN Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) PRSS2 TRY2 TRYP2 Homo sapiens (Human) antimicrobial humoral response [GO:0019730]; collagen catabolic process [GO:0030574]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LSSPAVINSR 1 4 0.89663 -0.23556 0 0 7.32787 0 0 0 0 0 0 0 0 0 P07510 ACHG_HUMAN Acetylcholine receptor subunit gamma CHRNG ACHRG Homo sapiens (Human) acetylcholine receptor signaling pathway [GO:0095500]; membrane depolarization [GO:0051899]; muscle contraction [GO:0006936]; signal transduction [GO:0007165] acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] YLTFLLVVTILIVVNAVVVLNVSLR 1 4.8 0.71197 0.15167 0 0 0 0 0 0 0 5.02228 0 0 0 0 P07550 ADRB2_HUMAN Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) ADRB2 ADRB2R B2AR Homo sapiens (Human) activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; adrenergic receptor signaling pathway [GO:0071875]; AMPA selective glutamate receptor signaling pathway [GO:0098990]; bone resorption [GO:0045453]; brown fat cell differentiation [GO:0050873]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; diet induced thermogenesis [GO:0002024]; endosome to lysosome transport [GO:0008333]; heat generation [GO:0031649]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of smooth muscle contraction [GO:0045986]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of lipophagy [GO:1904504]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of sodium ion transport [GO:0002028]; response to cold [GO:0009409]; response to psychosocial stress [GO:1990911]; smooth muscle contraction [GO:0006939]; transcription by RNA polymerase II [GO:0006366] apical plasma membrane [GO:0016324]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] adenylate cyclase binding [GO:0008179]; amyloid-beta binding [GO:0001540]; beta2-adrenergic receptor activity [GO:0004941]; identical protein binding [GO:0042802]; norepinephrine binding [GO:0051380]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] SPDFRIAFQELLCLR 1 3.6 0.81364 -0.010736 0 0 0 0 0 0 0 0 0 0 11.2647 0 P07585 PGS2_HUMAN Decorin (Bone proteoglycan II) (PG-S2) (PG40) DCN SLRR1B Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of autophagy [GO:0010508]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; RNA binding [GO:0003723] ELPEKMPK;TLQELRAHENEITKVR;VDAASLK 3 8.6 0.98103 -1.7362 0 0 0 0 0 8.7172 0 0 0 0 0 0 P07686 HEXB_HUMAN Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) astrocyte cell migration [GO:0043615]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; intracellular calcium ion homeostasis [GO:0006874]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; N-glycan processing [GO:0006491]; neuromuscular process controlling balance [GO:0050885]; neuron cellular homeostasis [GO:0070050]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; single fertilization [GO:0007338]; skeletal system development [GO:0001501] acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; identical protein binding [GO:0042802] DSAYPEELSR;IQDFMRQK;KLESFYIQK 3 4.9 0.97889 -2.0516 0 0 14.1234 0 0 0 0 0 11.1909 0 0 10.6717 P07737 PROF1_HUMAN Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) PFN1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074] blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634] "actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]" DSLLQDGEFSMDLR;DSPSVWAAVPGK;EGVHGGLINK;SSFYVNGLTLGGQK;STGGAPTFNVTVTK;TDKTLVLLMGK;TFVNITPAEVGVLVGKDR 7 66.4 0 117.83 14.0869 13.6668 12.1158 10.6482 10.3128 10.0728 13.82 14.6666 13.3935 13.775 13.4587 13.9665 P07738 PMGE_HUMAN "Bisphosphoglycerate mutase (BPGM) (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (EC 5.4.2.11) (2,3-diphosphoglycerate mutase) (DPGM) (BPG-dependent PGAM)" BPGM Homo sapiens (Human) carbohydrate derivative catabolic process [GO:1901136]; carbohydrate metabolic process [GO:0005975]; cellular response to stress [GO:0033554]; defense response to protozoan [GO:0042832]; erythrocyte development [GO:0048821]; establishment of blood-brain barrier [GO:0060856]; glycolytic process [GO:0006096]; neuroinflammatory response [GO:0150076]; oxygen transport [GO:0015671]; respiratory gaseous exchange by respiratory system [GO:0007585] cytosol [GO:0005829]; extracellular exosome [GO:0070062] "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]" IAPEVLR;NCGKQLK 2 5.4 0.9812 -2.0287 0 0 0 0 8.67271 0 0 0 0 0 0 0 P07741 APT_HUMAN Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) APRT Homo sapiens (Human) adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; IMP salvage [GO:0032264]; purine ribonucleoside salvage [GO:0006166] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774] adenine binding [GO:0002055]; adenine phosphoribosyltransferase activity [GO:0003999]; AMP binding [GO:0016208] ADSELQLVEQR;DALEPGQR;IDYIAGLDSR;LAPVPFFSLLQYE;SFPDFPTPGVVFR 5 30.6 0 57.116 11.5654 9.65816 11.3661 10.4233 10.5644 7.5352 11.2052 11.1005 9.17802 10.3968 11.7027 9.9993 P07766 CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e) CD3E T3E Homo sapiens (Human) "adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; apoptotic signaling pathway [GO:0097190]; calcium-mediated signaling [GO:0019722]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-delta T cell activation [GO:0046629]; negative regulation of gene expression [GO:0010629]; negative regulation of smoothened signaling pathway [GO:0045879]; negative thymic T cell selection [GO:0045060]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell anergy [GO:0002669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive thymic T cell selection [GO:0045059]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal complex assembly [GO:0007172]; smoothened signaling pathway [GO:0007224]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]" alpha-beta T cell receptor complex [GO:0042105]; cell body [GO:0044297]; cell-cell junction [GO:0005911]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888] DLYSGLNQRR;GAGAGGR;GQNKERPPPVPNPDYEPIR 3 17.4 0.9558 -0.87055 0 8.54423 0 0 0 8.9587 0 0 0 0 0 0 P07814 SYEP_HUMAN Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS1 EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; cellular response to type II interferon [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; regulation of long-chain fatty acid import into cell [GO:0140212]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; protein homodimerization activity [GO:0042803]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270] FVELPGAEMGK;LEVGPRDMK;LNLNNTVLSK;LNQWCNVVRWEFK;NSEPAGLETPEAK;QNDGQRK;YYTLFGR 7 4.6 0.95895 -1.0333 0 9.16471 9.38948 0 0 0 0 0 4.60229 8.91421 9.60001 11.0524 P07864 LDHC_HUMAN L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) LDHC LDH3 LDHX Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; flagellated sperm motility [GO:0030317]; lactate biosynthetic process from pyruvate [GO:0019244]; lactate metabolic process [GO:0006089]; pyruvate catabolic process [GO:0042867]; pyruvate metabolic process [GO:0006090] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204] L-lactate dehydrogenase activity [GO:0004459] ISGLPVTR;VIGSGCNLDSAR 2 6 0.82977 -0.022899 7.80155 0 0 0 0 0 0 0 16.2654 0 0 0 P07900 HS90A_HUMAN Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) HSP90AA1 HSP90A HSPC1 HSPCA Homo sapiens (Human) activation of innate immune response [GO:0002218]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to heat [GO:0034605]; cellular response to virus [GO:0098586]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial transport [GO:0006839]; neurofibrillary tangle assembly [GO:1902988]; neuron migration [GO:0001764]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell size [GO:0045793]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein polymerization [GO:0032273]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; protein unfolding [GO:0043335]; regulation of apoptotic process [GO:0042981]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to cold [GO:0009409]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to salt stress [GO:0009651]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004] apical plasma membrane [GO:0016324]; axonal growth cone [GO:0044295]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; sperm mitochondrial sheath [GO:0097226]; sperm plasma membrane [GO:0097524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; CTP binding [GO:0002135]; dATP binding [GO:0032564]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; GTP binding [GO:0005525]; GTPase binding [GO:0051020]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; nitric-oxide synthase regulator activity [GO:0030235]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; Rho GDP-dissociation inhibitor binding [GO:0051022]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; sulfonylurea receptor binding [GO:0017098]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; UTP binding [GO:0002134] ADLINNLGTIAK;ALLFVPR;APFDLFENR;DNSTMGYMAAK;DQVANSAFVER;EDQTEYLEER;EDQTEYLEERRIK;EGLELPEDEEEK;ELISNSSDALDK;ELISNSSDALDKIR;ELISNSSDALDKIRYESLTDPSK;EMLQQSK;FYEQFSK;GVVDSEDLPLNISR;LGIHEDSQNR;NPDDITNEEYGEFYK;SLTNDWEDHLAVK;TDTGEPMGR;TKPIWTR;TLVSVTK;VILHLKEDQTEYLEERR;YESLTDPSK;YESLTDPSKLDSGK;YIDQEELNK 24 28.3 0 128.25 14.3522 14.3408 14.4134 10.3639 10.9819 10.1511 8.61025 12.6514 13.5752 14.7327 14.9402 12.9965 P07910 HNRPC_HUMAN Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) HNRNPC HNRPC Homo sapiens (Human) "3'-UTR-mediated mRNA stabilization [GO:0070935]; chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of telomere maintenance via telomerase [GO:0032211]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]" actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; nucleosomal DNA binding [GO:0031492]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] AAVAGEDGR;AAVAGEDGRMIAGQVLDINLAAEPKVNR;ASNVTNK;AVVPSKR;DSANGEDDS;EAEEGEDDRDSANGEDDS;GDDQLELIK;GFAFVQYVNER;MIAGQVLDINLAAEPK;NDKSEEEQSSSSVK;QKVDSLLENLEK;SDVEAIFSK;VDSLLENLEK;VFIGNLNTLVVK;VPPPPPIAR 15 44.4 0 45.294 8.42882 13.3096 14.3392 12.0985 11.216 11.1511 13.4932 13.9474 14.1431 14.3507 14.0234 12.2355 P07942 LAMB1_HUMAN Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; neuron projection development [GO:0031175]; neuronal-glial interaction involved in cerebral cortex radial glia guided migration [GO:0021812]; odontogenesis [GO:0042476]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-2 complex [GO:0005607]; laminin-8 complex [GO:0043257]; perinuclear region of cytoplasm [GO:0048471]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201]; structural molecule activity [GO:0005198] ALDPAFK;ELAEQLEFIK;IQNLLKITNLRIK;LHTLGDNLLDSRMEIR 4 2.6 0.95901 -1.0087 0 0 0 0 5.82678 0 0 0 0 0 0 9.93477 P07948 LYN_HUMAN Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) LYN JTK8 Homo sapiens (Human) adaptive immune response [GO:0002250]; autophagy [GO:0006914]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; C-X-C chemokine receptor CXCR4 signaling pathway [GO:0038159]; cell morphogenesis [GO:0000902]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to heat [GO:0034605]; cellular response to retinoic acid [GO:0071300]; dendritic cell differentiation [GO:0097028]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; eosinophil differentiation [GO:0030222]; ephrin receptor signaling pathway [GO:0048013]; erythrocyte differentiation [GO:0030218]; fatty acid transport [GO:0015908]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; hematopoietic progenitor cell differentiation [GO:0002244]; histamine secretion by mast cell [GO:0002553]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; interleukin-5-mediated signaling pathway [GO:0038043]; leukocyte migration [GO:0050900]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of immune response [GO:0050777]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intracellular signal transduction [GO:1902532]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of myeloid leukocyte differentiation [GO:0002762]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neuroinflammatory response [GO:0150076]; neuron projection development [GO:0031175]; oligodendrocyte development [GO:0014003]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet degranulation [GO:0002576]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cytokine production [GO:0001817]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of erythrocyte differentiation [GO:0045646]; regulation of mast cell activation [GO:0033003]; regulation of mast cell degranulation [GO:0043304]; regulation of monocyte chemotaxis [GO:0090025]; regulation of platelet aggregation [GO:0090330]; regulation of protein phosphorylation [GO:0001932]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; response to sterol depletion [GO:0006991]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; tolerance induction to self antigen [GO:0002513]; toll-like receptor 4 signaling pathway [GO:0034142] "adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha2-beta1 complex [GO:0034666]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; mitochondrial crista [GO:0030061]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]" ATP binding [GO:0005524]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; gamma-tubulin binding [GO:0043015]; glycosphingolipid binding [GO:0043208]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; integrin binding [GO:0005178]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphoprotein binding [GO:0051219]; phosphorylation-dependent protein binding [GO:0140031]; platelet-derived growth factor receptor binding [GO:0005161]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] EEPIYIITEYMAKGSLLDFLK;VLEEHGEWWKAK 2 6.4 0.88937 -0.20701 0 0 0 0 0 10.7759 0 0 0 0 0 10.2937 P07949 RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] RET CDHF12 CDHR16 PTC Homo sapiens (Human) axon guidance [GO:0007411]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to retinoic acid [GO:0071300]; embryonic epithelial tube formation [GO:0001838]; enteric nervous system development [GO:0048484]; GDF15-GFRAL signaling pathway [GO:0160144]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innervation [GO:0060384]; lymphocyte migration into lymphoid organs [GO:0097021]; MAPK cascade [GO:0000165]; membrane protein proteolysis [GO:0033619]; neural crest cell migration [GO:0001755]; neuron cell-cell adhesion [GO:0007158]; neuron maturation [GO:0042551]; Peyer's patch morphogenesis [GO:0061146]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell size [GO:0045793]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; posterior midgut development [GO:0007497]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cell adhesion [GO:0030155]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; ureter maturation [GO:0035799]; ureteric bud development [GO:0001657] axon [GO:0030424]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor activity [GO:0038023]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ATSGAAGLRLLLLLLLPLLGK;CEWRQGDGK;DAPEEVPSFR;DLLSEFNVLK;DVYEEDSYVKRSQGR;ILEDPKWEFPR;ISHAFTR;LYGRISHAFTRF;VALGLYFSR;VFDADVVPASGELVR 10 10.4 0.9729 -2.9242 13.2579 12.5901 12.4411 7.43388 10.5147 8.30779 12.1917 12.2038 12.3215 9.39489 9.34285 9.33409 P07951 TPM2_HUMAN Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) TPM2 TMSB Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; regulation of ATP-dependent activity [GO:0043462] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862] actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] EAETRAEFAER;IQLVEEELDR;LATALQK;LEKTIDDLEDEVYAQK 4 15.5 0.91691 -0.42654 0 0 10.8217 0 0 0 0 0 0 0 0 0 P07951 TPM2_HUMAN Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) TPM2 TMSB Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; regulation of ATP-dependent activity [GO:0043462] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862] actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] AEHLQREADAER;EAETRAEFAER;IQLVEEELDR;LATALQK 4 16.1 0.98068 -1.6031 0 0 10.2212 0 0 0 0 0 0 0 0 0 P07954 FUMH_HUMAN "Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)" FH Homo sapiens (Human) arginine metabolic process [GO:0006525]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; malate metabolic process [GO:0006108]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of arginine metabolic process [GO:0000821]; tricarboxylic acid cycle [GO:0006099]; urea cycle [GO:0000050] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] fumarate hydratase activity [GO:0004333]; histone binding [GO:0042393] AIEMLGGELGSK;IANAIMKAADEVAEGK;IEYDTFGELK;IGGVTER;IPVHPNDHVNK 5 11 0.97743 -1.5222 0 0 11.9441 0 11.4107 0 0 0 8.80181 0 0 10.7091 P07992 ERCC1_HUMAN DNA excision repair protein ERCC-1 ERCC1 Homo sapiens (Human) cell population proliferation [GO:0008283]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryonic organ development [GO:0048568]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; male gonad development [GO:0008584]; mitotic recombination [GO:0006312]; multicellular organism growth [GO:0035264]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; oogenesis [GO:0048477]; positive regulation of t-circle formation [GO:1904431]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-embryonic hemopoiesis [GO:0035166]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; response to immobilization stress [GO:0035902]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to sucrose [GO:0009744]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; syncytium formation [GO:0006949]; t-circle formation [GO:0090656]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]" damaged DNA binding [GO:0003684]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; TFIID-class transcription factor complex binding [GO:0001094] ALGKNPR;EDLALCPGLGPQK 2 6.2 0.85067 -0.074443 0 0 0 0 0 0 0 8.69307 0 7.89887 0 0 P07996 TSP1_HUMAN Thrombospondin-1 (Glycoprotein G) THBS1 TSP TSP1 Homo sapiens (Human) apoptotic process [GO:0006915]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to tumor necrosis factor [GO:0071356]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide-cGMP-mediated signaling [GO:0038060]; peptide cross-linking [GO:0018149]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; sprouting angiogenesis [GO:0002040] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; sarcoplasmic reticulum [GO:0016529]; secretory granule [GO:0030141] calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; endopeptidase inhibitor activity [GO:0004866]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibroblast growth factor binding [GO:0017134]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; transforming growth factor beta binding [GO:0050431] CGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHR;DTDMDGVGDQCDNCPLEHNPDQLDSDSDR;NPCTDGTHDCNK;QVTQSYWDTNPTR 4 7.7 0.89784 -0.25394 5.46532 0 0 5.16322 5.23714 8.108 8.78898 11.3932 0 4.9534 0 0 P07998 RNAS1_HUMAN Ribonuclease pancreatic (EC 4.6.1.18) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A) RNASE1 RIB1 RNS1 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830] extracellular exosome [GO:0070062] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540] ALEKSLVRLLLLVLILLVLGWVQPSLGK;SLVRLLLLVLILLVLGWVQPSLGK 2 17.9 0.72702 0.12484 0 4.0054 8.07323 0 0 0 0 7.142 0 0 0 0 P08048 ZFY_HUMAN Zinc finger Y-chromosomal protein ZFY Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" DLPFRCK;DYPHKCEMCEK;DYPHRCEYCKK;GFRQQNELK;KKYHCTDCDYTTNK;YHCTDCDYTTNKK 6 6.6 0.97505 -3.4489 10.0083 10.0433 0 0 0 8.5606 8.73159 0 10.3873 0 0 0 P08069 IGF1R_HUMAN Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] IGF1R Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; axonogenesis [GO:0007409]; cardiac atrium development [GO:0003230]; cellular response to aldosterone [GO:1904045]; cellular response to amyloid-beta [GO:1904646]; cellular response to angiotensin [GO:1904385]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to progesterone stimulus [GO:0071393]; cellular response to testosterone stimulus [GO:0071394]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to zinc ion starvation [GO:0034224]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; dendritic spine maintenance [GO:0097062]; establishment of cell polarity [GO:0030010]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of muscle cell apoptotic process [GO:0010656]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of steroid hormone biosynthetic process [GO:0090031]; protein autophosphorylation [GO:0046777]; regulation of JNK cascade [GO:0046328]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to L-glutamate [GO:1902065]; response to nicotine [GO:0035094]; response to vitamin E [GO:0033197]; signal transduction [GO:0007165]; transcytosis [GO:0045056] alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; axon [GO:0030424]; caveola [GO:0005901]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein kinase complex [GO:1902911]; receptor complex [GO:0043235]; T-tubule [GO:0030315] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; G-protein alpha-subunit binding [GO:0001965]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein transporter activity [GO:0140318]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DIYETDYYR;GPCCACPK 2 1.2 0.91351 -0.39033 0 7.94322 0 0 0 0 0 0 0 0 0 0 P08123 CO1A2_HUMAN Collagen alpha-2(I) chain (Alpha-2 type I collagen) COL1A2 Homo sapiens (Human) blood vessel development [GO:0001568]; bone mineralization [GO:0030282]; cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; extracellular matrix assembly [GO:0085029]; extracellular matrix organization [GO:0030198]; odontogenesis [GO:0042476]; protein heterotrimerization [GO:0070208]; regulation of blood pressure [GO:0008217]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; SMAD binding [GO:0046332] GAAGIPGGK;GEPGNIGFPGPKGPTGDPGK;GEPGVVGAVGTAGPSGPSGLPGER;GPAGPPGK 4 4.5 0.97257 -1.368 0 0 0 0 0 0 12.4589 0 10.3417 10.2053 0 0 P08133 ANXA6_HUMAN Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) ANXA6 ANX6 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; calcium ion transport [GO:0006816]; mitochondrial calcium ion homeostasis [GO:0051560]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of sequestering of calcium ion [GO:0051283]; regulation of muscle contraction [GO:0006937] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cholesterol binding [GO:0015485]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786] CIRSTPEYFAERLFK;DAISGIGTDEK;LMLAVVK;LVFDEYLK;NKPLFFADKLYK;SELDMLDIREIFR 6 9.8 0.97731 -2.1723 16.0527 11.6165 0 6.78097 8.93239 8.83476 0 0 0 8.59235 0 9.86862 P08134 RHOC_HUMAN Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) RHOC ARH9 ARHC Homo sapiens (Human) "actin filament organization [GO:0007015]; apical junction assembly [GO:0043297]; mitotic cytokinesis [GO:0000281]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of lipase activity [GO:0060193]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; skeletal muscle satellite cell migration [GO:1902766]; small GTPase-mediated signal transduction [GO:0007264]; wound healing, spreading of cells [GO:0044319]" cleavage furrow [GO:0032154]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] AGLQVRKNK;EVFEMATR 2 8.8 0.0045351 1.2137 0 0 0 2.956 0 2.32291 0 10.8375 0 2.93943 0 0 P08138 TNR16_HUMAN Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) NGFR TNFRSF16 Homo sapiens (Human) axon guidance [GO:0007411]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; detection of temperature stimulus [GO:0016048]; dorsal aorta development [GO:0035907]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast proliferation [GO:0048144]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of hair follicle development [GO:0051799]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of protein localization to nucleus [GO:1900182]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Rho protein signal transduction [GO:0007266] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793] amyloid-beta binding [GO:0001540]; calmodulin binding [GO:0005516]; coreceptor activity [GO:0015026]; death receptor activity [GO:0005035]; nerve growth factor binding [GO:0048406]; neurotrophin binding [GO:0043121]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625] CAYGYYQDETTGRCEACR;GAGATGR 2 5.9 0.82956 -0.024498 0 0 0 0 0 0 0 0 0 10.8681 0 0 P08151 GLI1_HUMAN Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) GLI1 GLI Homo sapiens (Human) cerebellar cortex morphogenesis [GO:0021696]; digestive tract morphogenesis [GO:0048546]; dorsal/ventral pattern formation [GO:0009953]; epidermal cell differentiation [GO:0009913]; liver regeneration [GO:0097421]; lung development [GO:0030324]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; notochord regression [GO:0060032]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of DNA-templated transcription [GO:0006355]; regulation of hepatocyte proliferation [GO:2000345]; regulation of osteoblast differentiation [GO:0045667]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]; ventral midline development [GO:0007418] axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" EGGPIREESR;HRGDGPLPRAPSISTVEPK;IGGLPMPPWRSR;SELDMLVGK 4 4.5 0.9729 -2.9206 0 0 0 0 0 0 0 0 0 0 0 11.4423 P08174 DAF_HUMAN Complement decay-accelerating factor (CD antigen CD55) CD55 CR DAF Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]" cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; transport vesicle [GO:0030133] lipid binding [GO:0008289]; virus receptor activity [GO:0001618] EPSLSPK;REPPHLARAHVFHVDR;TTKHFHETTPNK;TTTKTTTPNAQATR 4 11.2 0.96134 -1.0616 0 0 0 0 0 0 8.78398 0 0 8.64685 10.5308 0 P08183 MDR1_HUMAN ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; ceramide translocation [GO:0099040]; export across plasma membrane [GO:0140115]; G2/M transition of mitotic cell cycle [GO:0000086]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; response to xenobiotic stimulus [GO:0009410]; stem cell proliferation [GO:0072089]; terpenoid transport [GO:0046865]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; ceramide floppase activity [GO:0099038]; efflux transmembrane transporter activity [GO:0015562]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylethanolamine flippase activity [GO:0090555]; transmembrane transporter activity [GO:0022857]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910] DLEGDRNGGAK;LANDAAQVK;STVVQLLERFYDPLAGK 3 2.9 0.95712 -1.0227 10.9804 0 0 8.78692 0 0 0 0 0 0 0 9.48965 P08185 CBG_HUMAN Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin) SERPINA6 CBG Homo sapiens (Human) glucocorticoid metabolic process [GO:0008211] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867]; steroid binding [GO:0005496] GLASANVDFAFSLYK;ITQDAQLKSSK 2 6.4 0.87361 -0.11624 12.736 0 0 0 0 0 0 0 0 0 0 10.5939 P08195 4F2_HUMAN Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 MDU1 Homo sapiens (Human) amino acid transport [GO:0006865]; calcium ion transport [GO:0006816]; carbohydrate metabolic process [GO:0005975]; isoleucine transport [GO:0015818]; L-alanine import across plasma membrane [GO:1904273]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; methionine transport [GO:0015821]; phenylalanine transport [GO:0015823]; proline transport [GO:0015824]; response to exogenous dsRNA [GO:0043330]; symbiont entry into host cell [GO:0046718]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829] amino acid transport complex [GO:1990184]; anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; apical pole of neuron [GO:0044225]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] aromatic amino acid transmembrane transporter activity [GO:0015173]; cadherin binding [GO:0045296]; double-stranded RNA binding [GO:0003725]; exogenous protein binding [GO:0140272]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618] ADLLLSTQPGR;ADLLLSTQPGREEGSPLELER;DDVAQTDLLQIDPNFGSK;EDFDSLLQSAK;EEGSPLELER;EVELNELEPEK;FTGLSKEELLK;GENSWFSTQVDTVATK;GLVLGPIHK;GQSEDPGSLLSLFR;IGDLQAFQGHGAGNLAGLK;IKVAEDEAEAAAAAK;LDYLSSLK;LLTSFLPAQLLR;MELQPPEASIAVVSIPR;VAEDEAEAAAAAK;VAGSPGWVR;VILDLTPNYR 18 31.9 0 72.125 12.4992 12.5246 10.3216 9.80172 7.4065 9.82809 14.0904 13.5358 13.9082 14.0914 14.0794 10.632 P08195 4F2_HUMAN Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 MDU1 Homo sapiens (Human) amino acid transport [GO:0006865]; calcium ion transport [GO:0006816]; carbohydrate metabolic process [GO:0005975]; isoleucine transport [GO:0015818]; L-alanine import across plasma membrane [GO:1904273]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; methionine transport [GO:0015821]; phenylalanine transport [GO:0015823]; proline transport [GO:0015824]; response to exogenous dsRNA [GO:0043330]; symbiont entry into host cell [GO:0046718]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829] amino acid transport complex [GO:1990184]; anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; apical pole of neuron [GO:0044225]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] aromatic amino acid transmembrane transporter activity [GO:0015173]; cadherin binding [GO:0045296]; double-stranded RNA binding [GO:0003725]; exogenous protein binding [GO:0140272]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618] ADLLLSTQPGR;ADLLLSTQPGREEGSPLELER;DDVAQTDLLQIDPNFGSK;EDFDSLLQSAK;EEGSPLELER;EVELNELEPEK;FTGLSKEELLK;GENSWFSTQVDTVATK;GLVLGPIHK;GQSEDPGSLLSLFR;IGDLQAFQGHGAGNLAGLK;IKVAEDEAEAAAAAK;LDYLSSLK;LLTSFLPAQLLR;SQDTEVDMK;VAEDEAEAAAAAK;VAGSPGWVR;VILDLTPNYR 18 36.5 0.015625 0.76545 0 0 0 0 0 0 0 0 0 8.5091 0 0 P08217 CEL2A_HUMAN Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2A) CELA2A ELA2A Homo sapiens (Human) insulin catabolic process [GO:1901143]; proteolysis [GO:0006508]; regulation of insulin secretion [GO:0050796]; regulation of platelet aggregation [GO:0090330]; response to insulin [GO:0032868] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; keratohyalin granule [GO:0036457] endopeptidase activity [GO:0004175]; serine hydrolase activity [GO:0017171]; serine-type endopeptidase activity [GO:0004252] GNDIALLKLANPVSLTDK;LGCNYYHKPSVFTR;WQVHGIVSFGSR 3 16.4 0.95622 -0.85148 0 10.4626 0 0 0 0 0 11.7684 9.23028 0 0 0 P08236 BGLR_HUMAN Beta-glucuronidase (EC 3.2.1.31) (Beta-G1) GUSB Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; hyaluronan catabolic process [GO:0030214] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020] beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; signaling receptor binding [GO:0005102] YWKIANETR 1 1.4 0.98087 -1.5748 0 0 0 9.23014 0 0 0 0 0 0 0 0 P08237 PFKAM_HUMAN "ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)" PFKM PFKX Homo sapiens (Human) "canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycolysis from storage polysaccharide through glucose-1-phosphate [GO:0093001]; glycolytic process [GO:0006096]; glycolytic process through fructose-6-phosphate [GO:0061615]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of insulin secretion [GO:0032024]; positive regulation of transcription by RNA polymerase II [GO:0045944]" 6-phosphofructokinase complex [GO:0005945]; apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; sperm principal piece [GO:0097228] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] AMDEKKFDEALK;GITNLCVIGGDGSLTGADTFR;LRPILKILAK 3 5.5 0.75118 0.081146 0 0 7.53947 0 0 0 0 0 9.46031 10.0849 4.07613 0 P08238 HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB Homo sapiens (Human) cellular response to heat [GO:0034605]; cellular response to interleukin-4 [GO:0071353]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; placenta development [GO:0001890]; positive regulation of cell differentiation [GO:0045597]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; supramolecular fiber organization [GO:0097435]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]; virion attachment to host cell [GO:0019062] aryl hydrocarbon receptor complex [GO:0034751]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; HSP90-CDC37 chaperone complex [GO:1990565]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein binding [GO:0043008]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase regulator activity [GO:0030235]; peptide binding [GO:0042277]; protein dimerization activity [GO:0046983]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein phosphatase activator activity [GO:0072542]; receptor ligand inhibitor activity [GO:0141069]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] ADHGEPIGR;ADLINNLGTIAK;ALLFIPR;APFDLFENK;DNSTMGYMMAK;EDQTEYLEER;EGLELPEDEEEK;ELISNASDALDK;ELISNASDALDKIR;ELKIDIIPNPQER;EMLQQSK;EQVANSAFVER;EREKEISDDEAEEEK;FYEAFSK;GVVDSEDLPLNISR;IDIIPNPQER;LGIHEDSTNR;LMKEILDK;NPDDITQEEYGEFYK;RAPFDLFENK;SIYYITGESK;SLTNDWEDHLAVK;SLVSVTK;TKPIWTR;TLTLVDTGIGMTK;TLTLVDTGIGMTKADLINNLGTIAK;VILHLKEDQTEYLEERR;YESLTDPSK;YESLTDPSKLDSGK;YHTSQSGDEMTSLSEYVSR;YIDQEELNK 31 39.2 0 323.31 17.2749 16.871 16.4602 14.6976 14.2677 14.175 15.6354 16.2897 16.2194 15.8399 15.6102 15.9457 P08240 SRPRA_HUMAN Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) SRPRA SRPR Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] AGAVEQLR;AGAVEQLRTHTR;LDFFTIFSK;LSALHPPEK;VMGTFSTVTSTVK 5 6.7 0.97838 -2.1242 0 0 0 0 0 0 0 7.14068 11.9098 0 10.105 10.9797 P08243 ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase) ASNS TS11 Homo sapiens (Human) asparagine biosynthetic process [GO:0006529]; cellular response to glucose starvation [GO:0042149]; L-asparagine biosynthetic process [GO:0070981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of mitotic cell cycle [GO:0045931] cytosol [GO:0005829] asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524] EAQVQYPLQTFAIGMEDSPDLLAAR;EGYYYRQVFERHYPGR;NGIEKHLLRETFEDSNLIPK;TKEGYYYRQVFER 4 11.2 0.96629 -1.2698 0 9.69101 0 0 11.6612 0 13.0826 8.65696 0 7.38879 0 0 P08247 SYPH_HUMAN Synaptophysin (Major synaptic vesicle protein p38) SYP Homo sapiens (Human) endocytosis [GO:0006897]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle priming [GO:0010807]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle membrane organization [GO:0048499] excitatory synapse [GO:0060076]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169] GALATYIFLQNKYRENNK 1 9.2 0.85966 -0.082008 0 0 0 0 0 0 0 8.59638 0 0 0 0 P08253 MMP2_HUMAN 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] MMP2 CLG4A Homo sapiens (Human) angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; bone trabecula formation [GO:0060346]; cell migration [GO:0016477]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; intramembranous ossification [GO:0001957]; luteinization [GO:0001553]; macrophage chemotaxis [GO:0048246]; negative regulation of cell adhesion [GO:0007162]; negative regulation of vasoconstriction [GO:0045906]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; parturition [GO:0007567]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell migration [GO:0030335]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to activity [GO:0014823]; response to amyloid-beta [GO:1904645]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to nicotine [GO:0035094]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; tissue remodeling [GO:0048771] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] endopeptidase activity [GO:0004175]; fibronectin binding [GO:0001968]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] FWRYNEVK;KPKWDKNQITYR;LENQSLK;LSQDDIK;SDGFLWCSTTYNFEK;VDAAFNWSKNK 6 9.1 0.9757 -3.4171 0 10.7596 0 6.97476 0 9.905 0 0 0 0 10.1619 11.6314 P08254 MMP3_HUMAN Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) MMP3 STMY1 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitric oxide [GO:0071732]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; innate immune response [GO:0045087]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein-containing complex assembly [GO:0031334]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645] cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] GNEVRAGYPR;KPRCGVPDVGHFR;YLENYYDLK 3 6.7 0.97946 -1.8984 0 0 0 10.3639 0 0 8.29066 0 0 0 0 0 P08294 SODE_HUMAN Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) SOD3 Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] copper ion binding [GO:0005507]; heparin binding [GO:0008201]; molecular adaptor activity [GO:0060090]; superoxide dismutase activity [GO:0004784] VTGVVLFRQLAPR 1 5.4 0.92389 -0.44981 6.94275 0 0 0 0 0 0 0 0 0 0 0 P08311 CATG_HUMAN "Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]" CTSG Homo sapiens (Human) angiotensin maturation [GO:0002003]; antibacterial humoral response [GO:0019731]; biofilm matrix disassembly [GO:0098786]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; monocyte chemotaxis [GO:0002548]; negative regulation of T cell activation [GO:0050868]; neutrophil activation [GO:0042119]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; platelet activation [GO:0030168]; positive regulation of immune response [GO:0050778]; positive regulation of platelet aggregation [GO:1901731]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; proteolysis [GO:0006508]; purinergic nucleotide receptor signaling pathway [GO:0035590] azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] caspase binding [GO:0089720]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] AIRHPQYNQR;GTDTLREVQLR;QICVGDRR 3 11.4 0.97497 -3.166 0 10.3859 0 9.2088 10.1775 0 0 0 0 0 0 0 P08319 ADH4_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain) ADH4 ADH2 Homo sapiens (Human) alcohol catabolic process [GO:0046164]; alcohol metabolic process [GO:0006066]; aldehyde metabolic process [GO:0006081]; ethanol metabolic process [GO:0006067]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; quinone metabolic process [GO:1901661]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; nucleoplasm [GO:0005654] alcohol dehydrogenase (NAD+) activity [GO:0004022]; aldose reductase (NADPH) activity [GO:0004032]; all-trans retinal binding [GO:0005503]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; NAD binding [GO:0051287]; NADPH:quinone reductase activity [GO:0003960]; retinol binding [GO:0019841]; S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity [GO:0051903]; zinc ion binding [GO:0008270] GTKGKVIK;IIGIDINSEKFVK;SVDSIPK 3 7.4 0.97787 -2.1599 11.4427 11.6222 0 0 0 0 0 0 0 9.77339 0 0 P08397 HEM3_HUMAN Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) HMBS PBGD UPS Homo sapiens (Human) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytoplasm [GO:0005737]; cytosol [GO:0005829] hydroxymethylbilane synthase activity [GO:0004418] GPQLAAQNLGISLANLLLSK 1 5.5 0.63134 0.17351 0 0 0 0 0 0 8.81897 0 0 0 0 0 P08473 NEP_HUMAN Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME EPN Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; learning or memory [GO:0007611]; lung development [GO:0030324]; neuropeptide processing [GO:0061837]; peptide metabolic process [GO:0006518]; placenta development [GO:0001890]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neurogenesis [GO:0050769]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; response to estrogen [GO:0043627]; sensory perception of pain [GO:0019233]; substance P catabolic process [GO:0010814] axon [GO:0030424]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] cardiolipin binding [GO:1901612]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]; oligopeptidase activity [GO:0070012]; peptide binding [GO:0042277]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] LIQNMDATTEPCTDFFK;LNNEYLELNYK;YSARDLQNLMSWR 3 5.5 0.91843 -0.40337 0 0 0 0 0 0 0 8.52763 9.2635 0 0 9.17819 P08476 INHBA_HUMAN Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF) INHBA Homo sapiens (Human) "activin receptor signaling pathway [GO:0032924]; androgen metabolic process [GO:0008209]; androst-4-ene-3,17-dione biosynthetic process [GO:1903449]; autophagy [GO:0006914]; cardiac fibroblast cell development [GO:0060936]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; cellular response to cholesterol [GO:0071397]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to oxygen-glucose deprivation [GO:0090650]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; endodermal cell differentiation [GO:0035987]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; GABAergic neuron differentiation [GO:0097154]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to aldosterone [GO:1904044]; roof of mouth development [GO:0060021]; Sertoli cell differentiation [GO:0060008]; SMAD protein signal transduction [GO:0060395]; striatal medium spiny neuron differentiation [GO:0021773]; testosterone biosynthetic process [GO:0061370]; transcription by RNA polymerase II [GO:0006366]" activin A complex [GO:0043509]; enzyme activator complex [GO:0150005]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; protein-containing complex binding [GO:0044877]; type II activin receptor binding [GO:0070699] AALLNAIRKLHVGK;EEEGEGKKK;GFLLASCWIIVR 3 8.2 0.30285 0.25079 5.65984 5.22153 0 0 0 0 0 9.16895 9.48226 0 0 10.3309 P08493 MGP_HUMAN Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) MGP MGLAP GIG36 Homo sapiens (Human) cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; structural constituent of bone [GO:0008147] NANTFISPQQRWR 1 12.6 0.92192 -0.44345 0 0 0 0 0 0 4.00962 0 0 0 0 9.66585 P08514 ITA2B_HUMAN "Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]" ITGA2B GP2B ITGAB Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of leukocyte migration [GO:0002687] blood microparticle [GO:0072562]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphaIIb-beta3 complex [GO:0070442]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090] LICNQKK;LSLNAELQLDRQKPR 2 2.1 0.96611 -1.2609 0 0 0 0 0 0 0 12.3399 0 0 0 0 P08519 APOA_HUMAN Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-) LPA Homo sapiens (Human) blood circulation [GO:0008015]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma lipoprotein particle [GO:0034358] apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] EVVLLLLLFLK;HFCGGTLISPEWVLTAAHCLK 2 1.6 0.64488 0.17154 0 0 0 6.28181 0 0 0 0 0 0 0 0 P08559 ODPA_HUMAN "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" PDHA1 PHE1A Homo sapiens (Human) acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254] metal ion binding [GO:0046872]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604] CWDYSHSLK;GANQWIK;LEEGPPVTTVLTR;VLSGASQKPR 4 9.1 0.89318 -0.22057 9.73811 11.5821 11.4392 11.0112 0 0 0 0 9.49023 0 0 0 P08572 CO4A2_HUMAN Collagen alpha-2(IV) chain [Cleaved into: Canstatin] COL4A2 Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; DNA-templated transcription [GO:0006351]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; negative regulation of angiogenesis [GO:0016525]; response to activity [GO:0014823] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090] DCSGGCQCYPEK;EERDRYR;GAPGVTGPK;GDDGSPGR;GLPGLPGPPGPTGAKGLR 5 3.2 0.98011 -1.5625 0 0 7.50613 6.26448 0 0 11.2494 0 0 8.06786 6.55867 0 P08574 CY1_HUMAN "Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)" CYC1 Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to glucagon [GO:0033762]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; respiratory chain complex III [GO:0045275] heme binding [GO:0020037]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] AAAAASLRGVVLGPR;AANNGALPPDLSYIVR;GAGLPGARAR;LAYRPPK 4 14.8 0.94042 -0.58477 0 0 11.2388 0 9.28884 9.41445 0 0 0 11.1234 0 0 P08575 PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 Homo sapiens (Human) alpha-beta T cell proliferation [GO:0046633]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; DN2 thymocyte differentiation [GO:1904155]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-delta T cell differentiation [GO:0042492]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; MAPK cascade [GO:0000165]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of interleukin-8 production [GO:0032677]; regulation of phagocytosis [GO:0050764]; regulation of T cell receptor signaling pathway [GO:0050856]; release of sequestered calcium ion into cytosol [GO:0051209]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction [GO:0007165]; stem cell development [GO:0048864]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] bleb [GO:0032059]; cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane microdomain [GO:0098857]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synapse [GO:0045202] "ankyrin binding [GO:0030506]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" EARKPFNQNK;ESEHDSDESSDDDSDSEEPSK;NCDFRVK 3 2.9 0.97307 -2.9486 0 0 0 0 0 0 11.0276 0 0 4.61288 0 0 P08581 MET_HUMAN Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Homo sapiens (Human) branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; establishment of skin barrier [GO:0061436]; excitatory postsynaptic potential [GO:0060079]; liver development [GO:0001889]; negative regulation of autophagy [GO:0010507]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; phagocytosis [GO:0006909]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of transcription by RNA polymerase II [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165] basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; molecular function activator activity [GO:0140677]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; semaphorin receptor activity [GO:0017154]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LVSARSVSPTTEMVSNESVDYR;MKAPAVLAPGILVLLFTLVQR;SEGSPLVVLPYMK 3 4 0.9095 -0.30067 0 0 0 0 0 7.94907 0 7.45409 0 0 0 9.08568 P08582 TRFM_HUMAN Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) MELTF MAP97 MFI2 Homo sapiens (Human) iron ion transport [GO:0006826]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756] cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; side of membrane [GO:0098552] iron ion binding [GO:0005506] GAFRCLVENAGDVAFVR;TVLGGMEVR 2 3.5 0.95616 -0.84461 0 0 0 11.9331 0 0 0 11.2804 0 5.74897 0 0 P08603 CFAH_HUMAN Complement factor H (H factor 1) CFH HF HF1 HF2 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; regulation of complement activation [GO:0030449]; regulation of complement activation, alternative pathway [GO:0030451]; regulation of complement-dependent cytotoxicity [GO:1903659]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139] complement component C3b binding [GO:0001851]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] IIYKENERFQYK;TDCLSLPSFENAIPMGEKKDVYK 2 2.8 0.95766 -1.0161 0 0 0 0 0 0 12.3627 0 0 0 0 0 P08620 FGF4_HUMAN Fibroblast growth factor 4 (FGF-4) (Heparin secretory-transforming protein 1) (HST) (HST-1) (HSTF-1) (Heparin-binding growth factor 4) (HBGF-4) (Transforming protein KS3) FGF4 HST HSTF1 KS3 Homo sapiens (Human) apoptotic process involved in morphogenesis [GO:0060561]; cartilage condensation [GO:0001502]; cell-cell signaling [GO:0007267]; cellular response to leukemia inhibitory factor [GO:1990830]; chondroblast differentiation [GO:0060591]; cranial suture morphogenesis [GO:0060363]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell apoptotic process [GO:1904019]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mesenchymal cell proliferation [GO:0010463]; negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201] GNRVSPTMKVTHFLPR;LPVAAQPK 2 11.7 0.91657 -0.36378 0 0 6.7952 0 0 0 0 0 0 0 5.91188 0 P08621 RU17_HUMAN U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of ATP-dependent activity [GO:0043462]; regulation of RNA splicing [GO:0043484]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619] DPIPYLPPLEK;EFEVYGPIK;GGADVNIR;LGGGLGGTR;LGGGLGGTRR;TLFVARVNYDTTESKLR;VLVDVERGRTVK;VNYDTTESK 8 15.3 0.012195 0.86176 0 0 12.1996 0 10.0188 0 0 12.3037 10.2929 9.69305 8.31225 0 P08631 HCK_HUMAN Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) HCK Homo sapiens (Human) cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cytokine-mediated signaling pathway [GO:0019221]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; innate immune response-activating signaling pathway [GO:0002758]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; leukocyte degranulation [GO:0043299]; leukocyte migration involved in immune response [GO:0002522]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764]; regulation of podosome assembly [GO:0071801]; respiratory burst after phagocytosis [GO:0045728]; type II interferon-mediated signaling pathway [GO:0060333] caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] EPIYIITEFMAK;GISRKDAER;MGCMKSK;QGDTVKHYK;TLDNGGFYISPR 5 9.3 0.95374 -0.77942 0 0 9.80816 0 0 7.3535 0 10.7743 9.91703 6.35131 0 0 P08648 ITA5_HUMAN Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] ITGA5 FNRA Homo sapiens (Human) "angiogenesis [GO:0001525]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory [GO:0007613]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to muscle activity [GO:0014850]; wound healing, spreading of epidermal cells [GO:0035313]" alphav-beta3 integrin-vitronectin complex [GO:0071062]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha5-beta1 complex [GO:0034674]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ruffle [GO:0001726] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; integrin binding [GO:0005178]; platelet-derived growth factor receptor binding [GO:0005161]; signaling receptor activity [GO:0038023]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618] LGFFKRSLPYGTAMEK;RRPPLLPLLLLLLPPPPR;WGPRRRPPLLPLLLLLLPPPPR 3 3.6 0.95754 -1.0201 13.1129 0 0 0 0 0 0 0 0 0 0 0 P08651 NFIC_HUMAN Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) NFIC NFI Homo sapiens (Human) DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DELLGEKPEVKQK;ELDLYLAYFVRER 2 5.1 0.95397 -0.8932 0 12.0351 0 0 0 0 8.12153 11.1732 0 0 0 0 P08670 VIME_HUMAN Vimentin VIM Homo sapiens (Human) astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to type II interferon [GO:0071346]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of gene expression [GO:0010628]; regulation of mRNA stability [GO:0043488] axon [GO:0030424]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] DGQVINETSQHHDDLE;EEAENTLQSFR;EMEENFAVEAANYQDTIGR;ETNLDSLPLVDTHSK;ETNLDSLPLVDTHSKR;EYQDLLNVK;FADLSEAANR;FADLSEAANRNNDALR;FLEQQNK;GTNESLER;HLREYQDLLNVK;ILLAELEQLKGQGK;ISLPLPNFSSLNLR;KLLEGEESR;LGDLYEEEMR;LLEGEESR;LLQDSVDFSLADAINTEFK;LLQDSVDFSLADAINTEFKNTR;LQEEMLQREEAENTLQSFR;MFGGPGTASRPSSSR;NLQEAEEWYK;QDVDNASLAR;QQYESVAAK;QVDQLTNDKAR;QVQSLTCEVDALKGTNESLER;SLYASSPGGVYATR;SSVPGVR;SVSSSSYR;SYVTTSTR;TYSLGSALRPSTSR 30 64.6 0 115.58 1.63473 8.87563 0 0 2.74481 0 0 4.5958 0 2.32441 10.0107 16.3509 P08686 CP21A_HUMAN Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B) CYP21A2 CYP21 CYP21B Homo sapiens (Human) glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] 17-hydroxyprogesterone 21-hydroxylase activity [GO:0103069]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; progesterone 21-hydroxylase activity [GO:0106309]; steroid 21-monooxygenase activity [GO:0004509]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395] ESLVAGQWR;LLWNWWK;LVSRNYPDLSLGDYSLLWK;MLLLGLLLLLPLLAGAR 4 10.5 0.97514 -1.4552 0 5.28451 8.93127 0 0 0 0 0 0 0 3.97526 0 P08700 IL3_HUMAN Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor) IL3 Homo sapiens (Human) cell surface receptor signaling pathway via STAT [GO:0097696]; cell-cell signaling [GO:0007267]; embryonic hemopoiesis [GO:0035162]; immune response [GO:0006955]; interleukin-3-mediated signaling pathway [GO:0038156]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-3 receptor binding [GO:0005135] DGDWNEFRR;NLLPCLPLATAAPTRHPIHIK 2 19.7 0.76493 0.066637 0 0 13.0663 0 8.98638 0 0 0 0 0 0 0 P08708 RS17_HUMAN Small ribosomal subunit protein eS17 (40S ribosomal protein S17) RPS17 RPS17L Homo sapiens (Human) cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LGNDFHTNKR;RVCEEIAIIPSK 2 15.6 0.89609 -0.24132 0 0 11.3307 0 8.9443 0 0 0 0 0 0 0 P08727 K1C19_HUMAN "Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)" KRT19 Homo sapiens (Human) cell differentiation involved in embryonic placenta development [GO:0060706]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; Notch signaling pathway [GO:0007219]; response to estrogen [GO:0043627]; sarcomere organization [GO:0045214] apicolateral plasma membrane [GO:0016327]; cell periphery [GO:0071944]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; terminal web [GO:1990357]; Z disc [GO:0030018] structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] AALEDTLAETEAR;ALEAANGELEVK;DAEAWFTSR;EVAGHTEQLQMSR;FETEQALR;FGPGVAFR;GQVGGQVSVEVDSAPGTDLAK;GVSVSSAR;ILGATIENSR;IVLQIDNAR;LAADDFR;LASYLDK;LASYLDKVR;LEQEIATYR;LTMQNLNDRLASYLDK;NHEEEISTLR;QNQEYQR;QSSATSSFGGLGGGSVR;TKFETEQALR;TLQGLEIELQSQLSMK;VLDELTLAR 21 51.5 0 154.35 15.8514 15.3712 16.1425 12.9535 11.4927 12.3894 0 0 0 0 3.31079 0 P08729 K2C7_HUMAN "Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)" KRT7 SCL Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] AEAEAWYQTK;AKQEELEAALQR;AQYEEMAK;DVDAAYMSK;EVTINQSLLAPLR;EVTINQSLLAPLRLDADPSLQR;EYQELMSVK;FASFIDK;FASFIDKVR;FETLQAQAGK;FETLQAQAGKHGDDLR;FLEQQNK;FLEQQNKLLETKWTLLQEQK;GQLEALQVDGGR;KLLEGEESR;LDADPSLQR;LEAAIAEAEER;LEAAIAEAEERGELALK;LLEGEESR;LPDIFEAQIAGLR;LQAEIDNIK;LQAEIDNIKNQR;NEISEMNR;NEISEMNRAIQR;QEELEAALQR;QEESEQIK;SAAFSGR;SAYGGPVGAGIR;SIHFSSPVFTSR;SLDLDGIIAEVK;SMQDVVEDFK;TAAENEFVVLK;TAAENEFVVLKK;TASASRRSAR;TLNETELTELQSQISDTSVVLSMDNSR;VDALNDEINFLR;VRQEESEQIK;WTLLQEQK 38 67 0 323.31 8.20604 0 6.33987 9.94791 10.5568 9.36818 16.8418 16.9348 16.7173 16.4147 16.5145 4.20656 P08754 GNAI3_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) GNAI3 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell division [GO:0051301]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; GTP metabolic process [GO:0046039]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of macroautophagy [GO:0016239] centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] LKIDFGEAARADDAR;LLLLGAGESGK 2 7.3 0.85141 -0.079481 0 12.2358 0 0 0 0 0 0 0 0 0 0 P08758 ANXA5_HUMAN Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) ANXA5 ANX5 ENX2 PP4 Homo sapiens (Human) blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of coagulation [GO:0050819]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; sarcolemma [GO:0042383]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859]; phospholipid binding [GO:0005543] GAGTNEK;GLGTDEESILTLLTSR;GTVTDFPGFDER;LYDAYELK;QEISAAFK;SEIDLFNIR;VLTEIIASR 7 21.6 0 44.449 11.0298 0 0 0 0 0 13.826 13.8866 13.8567 0 11.9846 11.0266 P08865 RSSA_HUMAN Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) RPSA LAMBR LAMR1 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; virus receptor activity [GO:0001618] AIVAIENPADVSVISSR;FAAATGATPIAGR;FTPGTFTNQIQAAFREPR;LLVVTDPR 4 19 0 44.901 14.0623 13.8804 13.8857 10.1679 9.62282 10.7205 11.8248 12.7202 13.1622 13.0554 11.4528 13.1213 P08908 5HT1A_HUMAN 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A) HTR1A ADRB2RL1 ADRBRL1 Homo sapiens (Human) "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gamma-aminobutyric acid signaling pathway [GO:0007214]; positive regulation of cell population proliferation [GO:0008284]; regulation of behavior [GO:0050795]; regulation of dopamine metabolic process [GO:0042053]; regulation of hormone secretion [GO:0046883]; regulation of serotonin secretion [GO:0014062]; regulation of vasoconstriction [GO:0019229]; serotonin metabolic process [GO:0042428]; serotonin receptor signaling pathway [GO:0007210]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; receptor-receptor interaction [GO:0090722]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] IIKCKFCR;KNERNAEAK;RAAALISLTWLIGFLISIPPMLGWRTPEDR 3 11.1 0.97039 -1.3442 0 0 0 0 7.42962 0 0 0 0 3.06145 0 0 P08912 ACM5_HUMAN Muscarinic acetylcholine receptor M5 CHRM5 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]; transmission of nerve impulse [GO:0019226]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] G protein-coupled acetylcholine receptor activity [GO:0016907]; phosphatidylinositol phospholipase C activity [GO:0004435] DLADLQGSDSVTK;IMPCPFPVAKEPSTK;IYRETEK;SQKCVAYK;VEEKLYWQGNSK 5 10.3 0.97545 -4.2762 11.6988 0 0 0 0 0 0 0 0 0 9.08454 0 P08913 ADA2A_HUMAN Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) ADRA2A ADRA2R ADRAR Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adrenergic receptor signaling pathway [GO:0071875]; cellular response to hormone stimulus [GO:0032870]; DNA replication [GO:0006260]; fear response [GO:0042596]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intestinal absorption [GO:0050892]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of insulin secretion [GO:0046676]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of uterine smooth muscle contraction [GO:0070473]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of wound healing [GO:0090303]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Ras protein signal transduction [GO:0007265]; receptor transactivation [GO:0035624]; regulation of vasoconstriction [GO:0019229]; response to alcohol [GO:0097305]; response to morphine [GO:0043278]; Rho protein signal transduction [GO:0007266]; thermoception [GO:0050955]; vasodilation [GO:0042311] axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235] alpha-1B adrenergic receptor binding [GO:0031692]; alpha-2C adrenergic receptor binding [GO:0031696]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; guanyl-nucleotide exchange factor activity [GO:0005085]; heterotrimeric G-protein binding [GO:0032795]; norepinephrine binding [GO:0051380]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996] YWSITQAIEYNLKR 1 3 0.3434 0.23836 0 0 0 0 8.04652 0 0 0 0 0 0 0 P08922 ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ROS1 MCF3 ROS Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CFIAFQVR;GLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLR 2 2 0.91607 -0.34878 6.9273 6.29006 0 0 0 0 0 0 0 8.01184 0 0 P08949 NMB_HUMAN Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B] NMB Homo sapiens (Human) antiviral innate immune response [GO:0140374]; arachidonate secretion [GO:0050482]; cell-cell signaling [GO:0007267]; Leydig cell proliferation [GO:0160024]; negative regulation of hormone secretion [GO:0046888]; negative regulation of interleukin-6 production [GO:0032715]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hormone secretion [GO:0046887]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; positive regulation of testosterone secretion [GO:2000845]; sensory perception of itch [GO:0160025]; signal transduction [GO:0007165]; sneeze reflex [GO:0160023] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005] hormone activity [GO:0005179]; neuromedin B receptor binding [GO:0031710]; neuropeptide hormone activity [GO:0005184] ALGVSLSRPAPQIQYRRLLVQILQK;LQLSHDLLGILLLKK 2 33.1 0.072581 0.41382 0 0 0 3.92458 0 0 0 0 0 0 0 4.85569 P08F94 PKHD1_HUMAN Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin) PKHD1 FCYT TIGM1 Homo sapiens (Human) branching morphogenesis of an epithelial tube [GO:0048754]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; homeostatic process [GO:0042592]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell adhesion [GO:0030155]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of centrosome duplication [GO:0010824]; regulation of cholangiocyte proliferation [GO:1904054]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of planar polarity [GO:0090175]; regulation of TOR signaling [GO:0032006] "9+0 non-motile cilium [GO:0097731]; apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]" signaling receptor activity [GO:0038023] EEDSCEAAR;LSKQSGSLGLSQEK;LTNFLQIGQNQIR;NIQIQPDVSCR;VGTLENPLEKEQKLLILLR 5 1.6 0.97345 -2.4719 8.81035 0 0 8.17313 0 0 0 0 0 0 0 9.45222 P09016 HXD4_HUMAN Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1) HOXD4 HOX4B Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell differentiation [GO:0048863] cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" TAYTRQQVLELEKEFHFNR 1 7.5 0.96414 -1.0942 0 0 0 0 0 0 0 0 0 10.3147 0 0 P09017 HXC4_HUMAN Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) HOXC4 HOX3E Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RIEIAHSLCLSER 1 4.9 0.3441 0.23728 0 0 0 6.61063 0 0 0 0 0 0 0 0 P09104 ENOG_HUMAN Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) ENO2 Homo sapiens (Human) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; perikaryon [GO:0043204]; phosphopyruvate hydratase complex [GO:0000015]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] AAVPSGASTGIYEALELR;GNPTVEVDLYTAK;IVIGMDVAASEFYR;SGETEDTFIADLVVGLCTGQIK 4 15.4 0 1.9844 0 8.77735 0 0 10.0723 9.83159 0 13.1748 0 0 0 12.517 P09105 HBAT_HUMAN Hemoglobin subunit theta-1 (Hemoglobin theta-1 chain) (Theta-1-globin) HBQ1 Homo sapiens (Human) cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ALSAEDR;ALVRALWK 2 10.6 0.93356 -0.50796 0 0 0 0 0 0 0 0 0 2.18732 0 0 P09131 P3_HUMAN P3 protein (Solute carrier family 10 member 3) SLC10A3 DXS253E P3 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; response to retinoic acid [GO:0032526] membrane [GO:0016020] bile acid:sodium symporter activity [GO:0008508] FSQLLLQVVKPFSFVLLLGGLFLAYR;ILGTLLFIAIPIAVGVLIK 2 9.4 0.66725 0.16869 0 7.97968 8.02331 4.42001 0 0 7.71912 0 7.99661 7.51987 8.32953 0 P09132 SRP19_HUMAN Signal recognition particle 19 kDa protein (SRP19) SRP19 Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" "cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; RNA binding [GO:0003723] SVMLYAAEMIPK;VQLKQEDGSLCLVQFPSR 2 20.8 0.91723 -0.42522 0 9.54444 11.6547 0 0 0 0 0 0 0 0 0 P09132 SRP19_HUMAN Signal recognition particle 19 kDa protein (SRP19) SRP19 Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" "cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; RNA binding [GO:0003723] LLKILQLQRFK 1 14.1 0.61361 0.17438 0 6.95582 4.76908 0 5.66451 5.22219 0 0 0 0 4.52475 10.319 P09211 GSTP1_HUMAN Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) GSTP1 FAEES3 GST3 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; central nervous system development [GO:0007417]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nitric oxide storage [GO:0035732]; positive regulation of superoxide anion generation [GO:0032930]; prostaglandin metabolic process [GO:0006693]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to reactive oxygen species [GO:0000302]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; TRAF2-GSTP1 complex [GO:0097057]; vesicle [GO:0031982] dinitrosyl-iron complex binding [GO:0035731]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; JUN kinase binding [GO:0008432]; kinase regulator activity [GO:0019207]; nitric oxide binding [GO:0070026]; S-nitrosoglutathione binding [GO:0035730] AFLASPEYVNLPINGNGKQ;ALPGQLKPFETLLSQNQGGK;ASCLYGQLPKFQDGDLTLYQSNTILRHLGR;DQQEAALVDMVNDGVEDLR;EEVVTVETWQEGSLK;FQDGDLTLYQSNTILR;LKAFLASPEYVNLPINGNGKQ;MPPYTVVYFPVR;PPYTVVYFPVR;TLGLYGK 10 59 0 209.29 15.7018 14.5836 15.6168 12.2827 12.0886 12.0262 12.5075 13.1028 13.244 12.0232 10.3902 0 P09238 MMP10_HUMAN Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) MMP10 STMY2 Homo sapiens (Human) collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] DLAQQYLEK;IDAAVSDKEK;KTHLTYRIVNYTPDLPR 3 7.6 0.97986 -1.8719 0 0 0 0 0 0 0 12.2091 0 0 0 0 P09326 CD48_HUMAN CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48) CD48 BCM1 BLAST1 Homo sapiens (Human) defense response [GO:0006952]; immune response [GO:0006955]; natural killer cell activation [GO:0030101] extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] receptor ligand activity [GO:0048018] IEDMDDNCYLK;IKLQVLDPVPKPVIKIEK;YFESKFK 3 14.8 0.97284 -2.7727 0 0 0 0 0 0 6.46909 0 0 0 0 0 P09327 VILI_HUMAN Villin-1 VIL1 VIL Homo sapiens (Human) actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; apoptotic process [GO:0006915]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; intestinal D-glucose absorption [GO:0001951]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein-containing complex assembly [GO:0065003]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of microvillus length [GO:0032532]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]; terminal web assembly [GO:1902896] actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]" AAVPDTVVEPALK;ANFLNSNDVFVLK;DPETPIIVVK;DWSQITAEVTSPK;EIRDQERGGR;HVETNSYDVQR;IENLELVPVDSK;LFQVQGTGANNTK;LQEENLVITPR;MERLRGMTLAK;MVADTISR;MVVYQGGTSR;TNNLETGPSTR;TQSCCYLWCGK;TYVGVVDGENELASPK 15 20.9 0 40.007 14.7348 14.3178 14.3937 11.7708 11.8306 12.0687 9.71637 9.69853 0 0 9.49095 5.38974 P09341 GROA_HUMAN Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] CXCL1 GRO GRO1 GROA MGSA SCYB1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neutrophil chemotaxis [GO:0030593]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] LLRVALLLLLLVAAGR;LLRVALLLLLLVAAGRR;VALLLLLLVAAGR;VALLLLLLVAAGRR 4 15.9 0.045936 0.49869 4.78236 0 6.61393 5.51295 0 4.4444 0 4.93301 0 0 0 0 P09382 LEG1_HUMAN Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) LGALS1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell-cell adhesion [GO:0098609]; myoblast differentiation [GO:0045445]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of viral entry into host cell [GO:0046598]; regulation of apoptotic process [GO:0042981]; T cell costimulation [GO:0031295] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; galectin complex [GO:1990724]; plasma membrane [GO:0005886] lactose binding [GO:0030395]; laminin binding [GO:0043236]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723] DGGAWGTEQR;SFVLNLGK 2 13.3 0 2.0616 0 0 0 0 0 0 0 0 0 10.5479 10.685 0 P09417 DHPR_HUMAN Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1) QDPR DHPR SDR33C1 Homo sapiens (Human) amino acid metabolic process [GO:0006520]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] "6,7-dihydropteridine reductase activity [GO:0004155]; electron transfer activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]" NRPSSGSLIQVVTTEGRTELTPAYF;SKSLFKNCDLMWK 2 15.6 0.97838 -2.1209 0 0 9.68629 0 9.69472 0 0 9.63778 0 0 0 0 P09429 HMGB1_HUMAN High mobility group protein B1 (High mobility group protein 1) (HMG-1) HMGB1 HMG1 Homo sapiens (Human) "activation of innate immune response [GO:0002218]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell chemotaxis [GO:0002407]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; myeloid dendritic cell activation [GO:0001773]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; neuron projection development [GO:0031175]; neutrophil clearance [GO:0097350]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA ligation [GO:0051106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mismatch repair [GO:0032425]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of viral entry into host cell [GO:0046598]; regulation of restriction endodeoxyribonuclease activity [GO:0032072]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of tolerance induction [GO:0002643]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 1 cell activation [GO:0035711]; T-helper 1 cell differentiation [GO:0045063]; V(D)J recombination [GO:0033151]" alphav-beta3 integrin-HMGB1 complex [GO:0035868]; cell surface [GO:0009986]; condensed chromosome [GO:0000793]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; transcription repressor complex [GO:0017053] "bubble DNA binding [GO:0000405]; C-X-C chemokine binding [GO:0019958]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA polymerase binding [GO:0070182]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; lyase activity [GO:0016829]; phosphatidylserine binding [GO:0001786]; RAGE receptor binding [GO:0050786]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]" GDPKKPR;GEHPGLSIGDVAK;HPDASVNFSEFSK;IKGEHPGLSIGDVAK;RPPSAFFLFCSEYRPK 5 23.7 0.012295 0.86716 0 0 0 0 0 0 0 10.8393 11.2579 0 0 9.63252 P09455 RET1_HUMAN Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) RBP1 CRBP1 Homo sapiens (Human) fatty acid transport [GO:0015908]; lipid homeostasis [GO:0055088]; retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776] cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] all-trans-retinol binding [GO:1904768]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501] VEGVVCK 1 5.2 0.90887 -0.30941 0 0 0 0 0 0 6.30387 0 0 0 0 0 P09467 F16P1_HUMAN "Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)" FBP1 FBP Homo sapiens (Human) "cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; cellular response to magnesium ion [GO:0071286]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to xenobiotic stimulus [GO:0071466]; dephosphorylation [GO:0016311]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; response to nutrient levels [GO:0031667]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "AMP binding [GO:0016208]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" AGGMATTGK;DFDPAVTEYIQR;EAVLDVIPTDIHQR 3 10.4 0.95498 -0.96258 0 0 0 0 6.69738 0 0 0 11.3663 0 6.63871 0 P09486 SPRC_HUMAN SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) SPARC ON Homo sapiens (Human) negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of endothelial cell migration [GO:0010595]; regulation of cell morphogenesis [GO:0022604]; regulation of synapse organization [GO:0050807]; semicircular canal morphogenesis [GO:0048752] basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; platelet alpha granule membrane [GO:0031092] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840] MRDWLKNVLVTLYER;YIPPCLDSELTEFPLR 2 10.2 0.97868 -2.0756 0 0 0 8.25569 0 0 0 0 0 9.9592 0 0 P09493 TPM1_HUMAN Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) TPM1 C15orf13 TMSA Homo sapiens (Human) actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] AELSEGQVR;EAETRAEFAER;IQLVEEELDR;LATALQK 4 13 0.87035 -0.09769 10.5148 0 0 0 0 0 0 0 0 0 0 0 P09493 TPM1_HUMAN Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) TPM1 C15orf13 TMSA Homo sapiens (Human) actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] EAETRAEFAER;IQLVEEELDR;LATALQK;SLQEQADAAEER 4 16.3 0.8063 0.011687 0 0 0 0 0 0 0 0 0 0 7.25701 0 P09496 CLCA_HUMAN Clathrin light chain A (Lca) CLTA Homo sapiens (Human) cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; synaptic vesicle endocytosis [GO:0048488] clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; spindle [GO:0005819]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] clathrin heavy chain binding [GO:0032050]; GTPase binding [GO:0051020]; peptide binding [GO:0042277]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] VARLCDFNPK 1 4 0.88746 -0.18325 0 0 0 0 8.97576 0 0 0 0 0 0 0 P09497 CLCB_HUMAN Clathrin light chain B (Lcb) CLTB Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; synaptic vesicle endocytosis [GO:0048488] ciliary membrane [GO:0060170]; clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] clathrin heavy chain binding [GO:0032050]; peptide binding [GO:0042277]; structural molecule activity [GO:0005198] LQELDAASKVTEQEWR 1 7 0.8124 -0.013541 0 0 0 8.44091 0 0 0 0 0 0 0 0 P09525 ANXA4_HUMAN Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) ANXA4 ANX4 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; zymogen granule membrane [GO:0042589] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859] AEIDMLDIR;DEGNYLDDALVRQDAQDLYEAGEKK;GLGTDDNTLIR;GLGTDEDAIISVLAYR;ISQTYQQQYGR;NRNHLLHVFDEYKR;SDTSFMFQR;SETSGSFEDALLAIVK 8 34.8 0 8.0078 9.49428 13.1487 11.9432 0 9.63831 7.77037 7.80929 9.72059 7.74873 12.8487 0 10.2709 P09529 INHBB_HUMAN Inhibin beta B chain (Activin beta-B chain) INHBB Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cellular response to thyroid hormone stimulus [GO:0097067]; defense response [GO:0006952]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; pituitary gland development [GO:0021983]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; response to gonadotropin [GO:0034698]; response to insecticide [GO:0017085]; response to wounding [GO:0009611]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; protein homodimerization activity [GO:0042803] MRGLNPGTVNSCCIPTK 1 4.2 0.82321 -0.018283 0 8.72342 0 0 0 0 0 0 0 0 0 0 P09543 CN37_HUMAN "2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)" CNP Homo sapiens (Human) adult locomotory behavior [GO:0008344]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule [GO:0005874]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; myelin sheath abaxonal region [GO:0035748]; myelin sheath adaxonal region [GO:0035749]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; synapse [GO:0045202] "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; cyclic nucleotide binding [GO:0030551]; RNA binding [GO:0003723]" AIFTGYYGK;DFLPLYFGWFLTK;VIVDKYR 3 6.9 0.93643 -0.54575 0 0 0 0 0 0 0 0 0 7.40369 14.6159 0 P09544 WNT2_HUMAN Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP) WNT2 INT1L1 IRP Homo sapiens (Human) atrial cardiac muscle tissue morphogenesis [GO:0055009]; canonical Wnt signaling pathway [GO:0060070]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; iris morphogenesis [GO:0061072]; labyrinthine layer blood vessel development [GO:0060716]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; mammary gland epithelium development [GO:0061180]; mesenchymal cell proliferation [GO:0010463]; midbrain dopaminergic neuron differentiation [GO:1904948]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Wnt signalosome [GO:1990909] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] ACSQGEVKSCSCDPK;ALMNLHNNRAGR;QHRWNCNTLDR 3 10.6 0.97962 -1.5474 11.9756 0 0 0 0 0 0 8.2351 3.54523 0 0 0 P09564 CD7_HUMAN T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7) CD7 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; immune response [GO:0006955]; positive regulation of T cell cytokine production [GO:0002726]; T cell activation [GO:0042110] membrane [GO:0016020]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] MAGPPRLLLLPLLLALAR 1 7.5 0.82945 -0.023775 0 0 0 6.91994 0 0 0 0 0 0 0 0 P09601 HMOX1_HUMAN Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] HMOX1 HO HO1 Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; endothelial cell proliferation [GO:0001935]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; low-density lipoprotein particle clearance [GO:0034383]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of ferroptosis [GO:0110076]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of chemokine production [GO:0032722]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of angiogenesis [GO:0045765]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; smooth muscle hyperplasia [GO:0014806]; wound healing involved in inflammatory response [GO:0002246] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] enzyme binding [GO:0019899]; heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] APGLRQR;YVKRLHEVGR 2 5.9 0.97504 -1.4443 0 0 0 0 0 0 0 0 0 2.36768 0 0 P09619 PGFRB_HUMAN Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) PDGFRB PDGFR PDGFR1 Homo sapiens (Human) aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; enzyme binding [GO:0019899]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; GTPase activator activity [GO:0005096]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phospholipase C activator activity [GO:0160185]; placental growth factor receptor activity [GO:0036332]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor activity [GO:0005017]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] EVDSDAYYVYR;GRGMPQPNIIWSACR;LLGEGYK;VVVISAILALVVLTIISLIILIMLWQK 4 5.4 0.8484 -0.071339 0 0 0 0 7.67553 4.13373 0 0 0 0 8.87517 0 P09622 DLDH_HUMAN "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)" DLD GCSL LAD PHE3 Homo sapiens (Human) "2-oxoglutarate metabolic process [GO:0006103]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; pyruvate metabolic process [GO:0006090]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]" acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254] dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660] EANLAASFGK 1 2 0.90444 -0.26885 12.4518 0 0 0 0 0 0 0 0 0 0 0 P09651 ROA1_HUMAN "Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]" HNRNPA1 HNRPA1 Homo sapiens (Human) "cellular response to glucose starvation [GO:0042149]; cellular response to sodium arsenite [GO:1903936]; import into nucleus [GO:0051170]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear export [GO:0051168]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA export from nucleus [GO:0006405]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; telomeric repeat-containing RNA binding [GO:0061752] EDSQRPGAHLTVK;EPEQLRK;NQGGYGGSSSSSSYGSGR;SSGPYGGGGQYFAKPR 4 14.5 0 17.305 0 6.75969 0 5.525 6.71136 9.92992 11.7875 0 0 11.2198 11.167 12.8727 P09661 RU2A_HUMAN U2 small nuclear ribonucleoprotein A' (U2 snRNP A') SNRPA1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620] SLTYLSILR;TFNPGAGLPTDK;TLLVNNNR 3 11.4 0.96425 -1.1656 0 0 0 0 0 0 0 0 0 0 10.7496 0 P09668 CATH_HUMAN Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] CTSH CPSB Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; bradykinin catabolic process [GO:0010815]; cellular response to thyroid hormone stimulus [GO:0097067]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; neuropeptide catabolic process [GO:0010813]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidase activity [GO:0010952]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to retinoic acid [GO:0032526]; surfactant homeostasis [GO:0043129]; T cell mediated cytotoxicity [GO:0001913]; zymogen activation [GO:0031638] alveolar lamellar body [GO:0097208]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity [GO:0030108]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; thyroid hormone binding [GO:0070324] KTYSTEEYHHR 1 3.3 0.66705 0.16858 0 0 0 0 0 0 0 0 0 7.33423 0 0 P09683 SECR_HUMAN Secretin SCT Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; brain development [GO:0007420]; diet induced thermogenesis [GO:0002024]; embryonic digestive tract development [GO:0048566]; hippocampus development [GO:0021766]; intracellular water homeostasis [GO:0009992]; negative regulation of gastrin-induced gastric acid secretion [GO:1903640]; pancreatic juice secretion [GO:0030157]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of somatostatin secretion [GO:0090274]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667] extracellular region [GO:0005576]; extracellular space [GO:0005615] digestive hormone activity [GO:0046659]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] APRPLLLLLLLLGGSAARPAPPRARR 1 21.5 0.68439 0.16504 0 0 0 0 0 0 0 0 0 0 6.60449 0 P09693 CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) CD3G T3G Homo sapiens (Human) adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; cell surface receptor signaling pathway [GO:0007166]; establishment or maintenance of cell polarity [GO:0007163]; gamma-delta T cell activation [GO:0046629]; positive thymic T cell selection [GO:0045059]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of lymphocyte apoptotic process [GO:0070228]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888] ASDKQTLLPNDQLYQPLKDR;QSRASDK 2 12.6 0.85051 -0.078695 7.26594 0 0 0 0 0 0 0 0 0 6.49729 0 P09758 TACD2_HUMAN Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1) TACSTD2 GA733-1 M1S1 TROP2 Homo sapiens (Human) negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell motility [GO:2000146]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of stem cell differentiation [GO:2000738]; regulation of epithelial cell proliferation [GO:0050678]; ureteric bud morphogenesis [GO:0060675]; visual perception [GO:0007601] basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleus [GO:0005634] DIKGESLFQGR;RLTAGLIAVIVVVVVALVAGMAVLVITNRR 2 12.7 0.96497 -1.1559 0 0 0 0 0 0 0 4.01015 0 0 0 0 P09769 FGR_HUMAN Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) FGR SRC2 Homo sapiens (Human) bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; defense response to Gram-positive bacterium [GO:0050830]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; myoblast proliferation [GO:0051450]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of natural killer cell activation [GO:0032815]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of innate immune response [GO:0045088]; regulation of phagocytosis [GO:0050764]; regulation of protein kinase activity [GO:0045859]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705] actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; Fc-gamma receptor I complex binding [GO:0034988]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; immunoglobulin receptor binding [GO:0034987]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] GVSGIGVTLFIALYDYEAR;LDMGGYYITTR 2 5.7 0.77453 0.04827 0 0 0 0 0 0 11.2127 0 0 10.0371 0 0 P09848 LPH_HUMAN Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] LCT LPH Homo sapiens (Human) cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733] external side of apical plasma membrane [GO:0098591]; plasma membrane [GO:0005886] beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803] AQVYKFSISWSR;LPEFTESEK;VGNRSELQHLATSR 3 1.8 0.98 -1.8734 12.5128 0 0 9.86248 0 0 0 0 10.0885 0 0 0 P09871 C1S_HUMAN Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] C1S Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] CVPVCGVPREPFEEKQR 1 2.5 0.4848 0.19005 8.5938 0 0 0 0 0 0 0 0 0 0 0 P09874 PARP1_HUMAN "Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]" PARP1 ADPRT PPOL Homo sapiens (Human) "apoptotic process [GO:0006915]; ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate biosynthetic process [GO:0016051]; cellular response to amyloid-beta [GO:1904646]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; cellular response to zinc ion [GO:0071294]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of innate immune response [GO:0045824]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of myofibroblast differentiation [GO:1904762]; positive regulation of necroptotic process [GO:0060545]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of single strand break repair [GO:1903518]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein autoprocessing [GO:0016540]; protein localization to chromatin [GO:0071168]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; regulation of base-excision repair [GO:1905051]; regulation of catalytic activity [GO:0050790]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of protein localization [GO:0032880]; replication fork reversal [GO:0071932]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]" chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-histidine ADP-ribosyltransferase activity [GO:0140815]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; NAD+-protein-tyrosine ADP-ribosyltransferase activity [GO:0140808]; nuclear estrogen receptor binding [GO:0030331]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] AEKTLGDFAAEYAKSNR;AEPVEVVAPR;DPIDVNYEK;EVEKMNK;KAMVEYEIDLQK;LEQMPSK;LQLLEDDKENR;LTVNPGTK;QQVPSGESAILDR;SGRASCKK;TTNFAGILSQGLR 11 11.3 0.97931 -1.5364 0 7.5549 13.3469 0 0 0 11.3666 9.35005 10.5507 11.1992 11.3831 10.9392 P09884 DPOLA_HUMAN DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) POLA1 POLA Homo sapiens (Human) "DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]; mitotic DNA replication initiation [GO:1902975]; regulation of type I interferon production [GO:0032479]" alpha DNA polymerase:primase complex [GO:0005658]; chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] EILMHTKEMVQK;VEAMALKPDLVNVIK 2 1.8 0.95564 -0.843 0 0 0 0 9.61493 0 0 14.3448 0 15.0074 0 16.6254 P09913 IFIT2_HUMAN Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54) IFIT2 CIG-42 G10P2 IFI54 ISG54 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; apoptotic mitochondrial changes [GO:0008637]; defense response to virus [GO:0051607]; negative regulation of protein binding [GO:0032091]; positive regulation of apoptotic process [GO:0043065]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] RNA binding [GO:0003723] ENGMYGK;NPEFTSGLAIASYRLDNWPPSQNAIDPLR;VCFEKALEK;VLLALKLHKMR 4 11.9 0.95688 -1.025 0 9.71029 0 9.01288 8.9788 9.12221 0 0 3.50386 0 0 0 P09917 LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506] DDQIHILKQHR;FMHMFQSSWNDFADFEK;QLPAVHPIFKLLVAHVR 3 6.7 0.95169 -0.7045 0 8.01413 0 0 9.42011 0 0 0 0 0 0 0 P09919 CSF3_HUMAN Granulocyte colony-stimulating factor (G-CSF) (Pluripoietin) (Filgrastim) (Lenograstim) CSF3 C17orf33 GCSF Homo sapiens (Human) cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; granulocyte differentiation [GO:0030851]; immune response [GO:0006955]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; response to ethanol [GO:0045471] endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202] cytokine activity [GO:0005125]; enzyme binding [GO:0019899]; granulocyte colony-stimulating factor receptor binding [GO:0005130]; growth factor activity [GO:0008083] AGGVLVASHLQSFLEVSYR 1 9.2 0.91001 -0.29493 0 0 0 11.2074 0 0 0 0 0 0 0 0 P09923 PPBI_HUMAN Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) ALPI Homo sapiens (Human) dephosphorylation [GO:0016311] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; zinc ion binding [GO:0008270] GNEVISVMNR;LLSRNPR;NLVQEWLAK;QAAEALDAAK;SVGVVTTTR 5 8.5 0.93601 -0.52734 0 0 0 0 0 0 9.45206 0 0 0 0 0 P09936 UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) UCHL1 Homo sapiens (Human) adult walking behavior [GO:0007628]; axon target recognition [GO:0007412]; axonal transport of mitochondrion [GO:0019896]; cellular response to xenobiotic stimulus [GO:0071466]; eating behavior [GO:0042755]; male germ cell proliferation [GO:0002176]; muscle cell development [GO:0055001]; negative regulation of MAP kinase activity [GO:0043407]; neuromuscular process [GO:0050905]; positive regulation of glycolytic process [GO:0045821]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of macroautophagy [GO:0016241]; response to ischemia [GO:0002931] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] alpha-2A adrenergic receptor binding [GO:0031694]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; omega peptidase activity [GO:0008242]; ribosome binding [GO:0043022]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] QFLSETEK 1 3.6 0.90955 -0.2956 0 0 0 0 0 0 0 0 0 0 0 12.1972 P09958 FURIN_HUMAN Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; blastocyst formation [GO:0001825]; collagen catabolic process [GO:0030574]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of viral entry into host cell [GO:0046598]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of endopeptidase activity [GO:0052548]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082]; viral translation [GO:0019081]; zymogen activation [GO:0031638] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] endopeptidase activity [GO:0004175]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236] DIGKRLEVR;LAEEAFFRGVSQGR 2 2.9 0.97851 -1.9053 0 0 0 0 0 0 0 10.9603 0 0 0 0 P09960 LKHA4_HUMAN Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) LTA4H LTA4 Homo sapiens (Human) leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; peptide catabolic process [GO:0043171]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270] KIYKFIQK;MATEQGRMKFTRPLFK;QIGPRTLVWSEKEQVEK;SLVLDTKDLTIEK;TWDHFWLNEGHTVYLER;VVINGQEVK;YALGERQSYK 7 14.7 0.93849 -0.57341 10.1807 8.94752 10.782 0 0 0 0 0 0 8.22139 10.5953 0 P09960 LKHA4_HUMAN Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) LTA4H LTA4 Homo sapiens (Human) leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; peptide catabolic process [GO:0043171]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270] KIYKFIQK;MATEQGRMKFTRPLFK;QIGPRTLVWSEKEQVEK;TWDHFWLNEGHTVYLER;VLDTKDLTIEKVVINGQEVK;VVINGQEVK;YALGERQSYK 7 15 0.47163 0.19077 0 0 0 0 0 9.96939 0 0 0 0 0 0 P09972 ALDOC_HUMAN Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) ALDOC ALDC Homo sapiens (Human) "epithelial cell differentiation [GO:0030855]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]" cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cytoskeletal protein binding [GO:0008092]; fructose-bisphosphate aldolase activity [GO:0004332] CQYVTEK;DDNGVPFVRTIQDK;DGADFAK;GILAADESVGSMAK;GVVPLAGTDGETTTQGLDGLSER;VLAAVYK 6 19.8 0 24.582 0 11.0158 0 0 0 0 0 9.64886 0 10.9943 0 0 P0C025 NUD17_HUMAN Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-) NUDT17 Homo sapiens (Human) NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742] peroxisome [GO:0005777] metal ion binding [GO:0046872]; NADH pyrophosphatase activity [GO:0035529] LWLQHLGRTPPPCKSAAYLDPGPAK;SAAYLDPGPAKEEWNMDPLPPNQGSGK;VSTGTKFALK 3 15.5 0.97293 -2.6193 0 0 11.14 8.39934 0 8.21237 11.4544 0 0 8.22395 0 11.6079 P0C091 FREM3_HUMAN FRAS1-related extracellular matrix protein 3 FREM3 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] metal ion binding [GO:0046872] ATDLDSDDK;SLKAEDQDSPHRLLK;SLWLDPLR 3 1.5 0.9781 -2.1438 0 0 0 0 0 0 0 11.1499 0 10.8367 0 0 P0C0L5 CO4B_HUMAN Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain] C4B CO4 CPAMD3; C4B_2 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; detection of molecule of bacterial origin [GO:0032490]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; opsonization [GO:0008228]; positive regulation of apoptotic cell clearance [GO:2000427]" axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; complement binding [GO:0001848]; endopeptidase inhibitor activity [GO:0004866] DVKAAANQMR;EPFLSCCQFAESLRKK;INVKVGGNSK;LSCPKEK;QGSFQGGFR;VDVQAGACEGK;VLSLAQEQVGGSPEK 7 4.5 0.97659 -5.4807 7.05322 1.66894 0 0 0 0 0 0 12.2135 11.131 0 12.1849 P0C0P6 NPS_HUMAN Neuropeptide S NPS Homo sapiens (Human) "neuropeptide signaling pathway [GO:0007218]; positive regulation of action potential [GO:0045760]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]" extracellular region [GO:0005576]; synapse [GO:0045202] LDRSKELAFLKPILEK;SKELAFLKPILEK;TSFQRAKS 3 27 0.97544 -3.4083 0 0 0 0 8.75425 0 0 0 0 12.3977 12.5173 0 P0C1H6 H2BFM_HUMAN Histone H2B type F-M (Histone H2B.s) (H2B/s) H2BW2 H2BFM Homo sapiens (Human) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AEASSETTSEEGQSIQEPK;IATEAGQLAHYTK 2 21.6 0.94173 -0.59716 12.8681 0 0 0 0 11.2099 0 0 0 0 0 0 P0C1Z6 TFPT_HUMAN TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) TFPT INO80F Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] actin filament [GO:0005884]; cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877] EIEQVNERVLNR 1 4.7 0.95218 -0.71011 0 0 0 9.67523 0 0 0 0 0 0 0 0 P0C221 CC175_HUMAN Coiled-coil domain-containing protein 175 CCDC175 C14orf38 Homo sapiens (Human) ALSPWTPGLGAGEK;DLREKMK;INLKREDIALQK;LTTELKEEEK;QKIHDENQKQLTFISQK;QYKIVLSEEEKAFLQK;RELEECVR;TVYQQQIK 8 11.6 0.97523 -3.3132 12.0532 0 10.238 0 8.81243 0 10.8256 0 6.98709 0 5.16189 0 P0C263 SBK2_HUMAN Serine/threonine-protein kinase SBK2 (EC 2.7.11.1) (SH3 domain-binding kinase family member 2) (Sugen kinase 69) (SgK069) SBK2 SGK069 Homo sapiens (Human) MAPK cascade [GO:0000165] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LTDFGHTRPR;VLLVTHRQKGTPLALK 2 7.5 0.90877 -0.30188 0 0 0 0 7.62994 0 0 0 0 0 10.0992 0 P0C2W7 CT47B_HUMAN Cancer/testis antigen family 47 member B1 (Cancer/testis antigen 47.13) (CT47.13) CT47B1 CT47.13 Homo sapiens (Human) EQEKEKDVENK 1 3.7 0.76497 0.062837 0 0 0 0 0 8.62812 0 0 0 0 0 0 P0C2Y1 NBPF7_HUMAN Putative NBPF family member NBPF7 (Putative neuroblastoma breakpoint family member 7) NBPF7P NBPF7 Homo sapiens (Human) cytoplasm [GO:0005737] LQESEEKEVLQDSPEER;QQFRNMK 2 5.7 0.98084 -1.6322 6.06119 0 9.35588 0 6.37546 0 0 0 0 9.21728 0 5.70752 P0C623 OR4Q2_HUMAN Olfactory receptor 4Q2 (olfactory receptor OR14-21) OR4Q2 OR4Q2P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVKSAMQKLWVR 1 3.8 0.95628 -0.84523 0 0 0 0 0 0 11.9362 0 0 0 0 0 P0C626 OR5G3_HUMAN Olfactory receptor 5G3 (Olfactory receptor 5G6) (Olfactory receptor OR11-213) OR5G3 OR5G3P OR5G6P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] NKEVKDAFR 1 2.9 0.80848 0.0066689 0 11.9661 0 0 0 0 0 0 0 0 0 0 P0C628 O5AC1_HUMAN Olfactory receptor 5AC1 (Olfactory receptor OR3-2) OR5AC1 OR5AC1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] EVIDALRR 1 2.6 0.84028 -0.043952 0 0 0 0 0 0 0 0 0 7.98766 0 0 P0C629 O10J4_HUMAN Olfactory receptor 10J4 OR10J4 OR10J4P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] EVKDALLR;IASAEGR;LILFVIFLVLYVLTLASNAIILIVIR 3 13.2 0.98037 -1.8137 10.6245 0 0 0 5.91416 6.50258 0 0 0 0 0 0 P0C671 BNIP5_HUMAN Protein BNIP5 BNIP5 C6orf222 Homo sapiens (Human) HAAEVTK 1 1.1 0.94169 -0.59389 0 0 0 0 0 0 0 0 0 0 10.4441 0 P0C6A0 ZGLP1_HUMAN GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1) ZGLP1 GLP1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" ISQKGRR;TPLWRDAEDGTPLCNACGIR 2 9.9 0.9043 -0.26771 0 0 0 0 0 0 0 0 0 8.82219 0 10.0174 P0C6C1 AN34C_HUMAN Ankyrin repeat domain-containing protein 34C ANKRD34C Homo sapiens (Human) pi-body [GO:0071546] ALGLDSPLTEK;GKEVIIITTDKSSSGTK;HVDQQSISK 3 6.9 0.97865 -1.9679 0 0 0 0 11.5488 10.2538 0 0 0 0 9.06423 0 P0C6P0 BCL8_HUMAN Putative protein BCL8 (Neurobeachin pseudogene 1) NBEAP1 BCL8 BCL8A Homo sapiens (Human) YLDGLSHGVPLLK 1 13 0.78426 0.018702 0 0 0 0 0 0 0 13.414 13.4926 0 0 0 P0C6S8 LIGO3_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (Leucine-rich repeat neuronal protein 2) (Leucine-rich repeat neuronal protein 6B) LINGO3 LERN2 LRRN6B Homo sapiens (Human) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] DLVRLRELHLAGALLAVVEPQAFLGLR;GDALRNLPDSVLFEYFVCR;HLAIASLEDQNFRR;LDNLTLLDLSENK;VTATAGEDVR 5 14 0.9552 -0.79271 0 0 0 8.75138 0 0 11.6828 0 0 0 0 11.3857 P0C7A2 F153B_HUMAN Protein FAM153B FAM153B Homo sapiens (Human) ELHLYSTWK;GCAYSCCLEVCCGEDEIVYPRMPGESTVCHRER 2 10.9 0.57925 0.1809 0 0 0 0 0 0 0 6.45743 0 0 0 0 P0C7H9 U17L7_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7 USP17L7 Homo sapiens (Human) protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] FPQEQNKTKPEFNVR;NVQYPKCR;TLTLPTSAKVLILVLK;TLTLPTSAKVLILVLKR 4 7.5 0.97876 -2.057 3.96791 3.86176 0 0 0 0 11.6676 0 5.30517 13.7929 5.82423 0 P0C7I6 CC159_HUMAN Coiled-coil domain-containing protein 159 CCDC159 Homo sapiens (Human) spermatid development [GO:0007286] sperm head-tail coupling apparatus [GO:0120212] TIVMIPDSQK;TLRDSEEMQR 2 6.7 0.89676 -0.23032 0 8.21388 0 7.29572 0 0 0 0 0 0 9.57367 0 P0C7M6 IQCF3_HUMAN IQ domain-containing protein F3 IQCF3 Homo sapiens (Human) calmodulin binding [GO:0005516] GVLVRRTLLVAALR 1 9.1 0.86974 -0.090952 0 0 0 0 0 0 0 0 0 9.00969 0 0 P0C7M7 ACSM4_HUMAN "Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 4)" ACSM4 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872] KSTAPYKYPR 1 1.7 0.76686 0.059248 0 0 0 0 0 0 0 0 0 0 9.26498 0 P0C7M8 CLC2L_HUMAN C-type lectin domain family 2 member L CLEC2L Homo sapiens (Human) membrane [GO:0016020] carbohydrate binding [GO:0030246] CYFFSEEPR;LVSTECLMTRPWVCSK 2 11.7 0.92037 -0.44641 0 0 0 4.10274 0 0 11.851 0 0 0 0 0 P0C7N4 T191B_HUMAN Transmembrane protein 191B TMEM191B Homo sapiens (Human) membrane [GO:0016020] ADRETRLFGGPR;GVQYSTESLMEEMARADRETR;LEEAERHK;SLPPIVTPASRRLGPR 4 14.7 0.97489 -3.7086 0 11.0988 0 0 0 0 0 0 0 0 0 9.67234 P0C7P0 CISD3_HUMAN "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (MitoNEET-related protein 2) (Miner2) (Mitochondrial inner NEET protein) (MiNT)" CISD3 Homo sapiens (Human) protein maturation by [2Fe-2S] cluster transfer [GO:0106034] mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" AEVGSPL;TPIKVELVAGKTYR;VELVAGK 3 16.5 0.96358 -1.1876 0 0 11.6453 0 0 0 12.1329 0 0 8.57361 9.74604 0 P0C7P3 SLN14_HUMAN Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)] SLFN14 Homo sapiens (Human) cellular response to magnesium ion [GO:0071286]; cellular response to manganese ion [GO:0071287]; mRNA catabolic process [GO:0006402]; platelet maturation [GO:0036345]; rRNA catabolic process [GO:0016075] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521] EALQRHLFPVTQEEVQFKPESLCKK;EVVGCKWEK;LHPQQVLNRCIQEEEDMR 3 5.7 0.97443 -2.447 0 6.10373 13.5183 6.2832 7.6252 0 7.37347 10.2495 11.3058 0 0 0 P0C7P4 UCRIL_HUMAN Putative cytochrome b-c1 complex subunit Rieske-like protein 1 (Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1) UQCRFS1P1 UQCRFSL1 Homo sapiens (Human) "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121]" EIRSVAAR;ESLSGQAVR;IEIKLSDIPEGKNMAFK;QQIYTVK;SGPFAPVLSATSR 5 19.1 0.97348 -2.6357 0 0 0 0 0 9.62892 0 10.7339 0 8.92044 9.54266 0 P0C7Q5 S35G4_HUMAN Putative solute carrier family 35 member G4 (Acyl-malonyl-condensing enzyme 1-like protein 1) SLC35G4 AMAC1L1 SLC35G4P Homo sapiens (Human) membrane [GO:0016020] CLFHLPIALLLKLR;NLICERTGKVEE 2 7.7 0.97771 -1.5176 0 0 0 0 0 0 0 0 4.11753 0 0 10.4127 P0C7T5 ATX1L_HUMAN Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) ATXN1L BOAT BOAT1 Homo sapiens (Human) brain development [GO:0007420]; extracellular matrix organization [GO:0030198]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; social behavior [GO:0035176]; transcription by RNA polymerase II [GO:0006366] dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; POZ domain binding [GO:0031208]; RNA binding [GO:0003723] AALLRPSFIPQEVKLSIEGRSNAGK;GSARNPAELAEK;MKPVHERSQECLPPK 3 7.5 0.95165 -0.7142 0 0 0 0 0 0 0 0 0 10.1836 4.77389 0 P0C7T7 FMAS1_HUMAN Putative uncharacterized protein FRMD6-AS1 (FRMD6 antisense RNA 1) (FRMD6 antisense gene protein 1) FRMD6-AS1 C14orf82 Homo sapiens (Human) ASWVSRWMEGAPPR;GGVDHGDQGLSPCCGDGGAR;GRLFGLSVVLLKR;GSCALSSRQYGERPPAPPWTQPSVPR;RASWVSR 5 20.4 0.91722 -0.35464 3.52218 0 5.60851 0 0 0 12.2829 9.77686 12.4907 0 0 0 P0C7U0 ELFN1_HUMAN Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) ELFN1 PPP1R28 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; establishment of protein localization [GO:0045184]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic membrane adhesion [GO:0099560]; visual perception [GO:0007601] axon terminus [GO:0043679]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] protein phosphatase inhibitor activity [GO:0004864] ASQSIWERFRLSR;ASTSSSGSVRSPRAFR;LVESADTPK;NLTEGMLRGLGK;TGDPPER 5 6.9 0.97816 -2.14 0 9.97513 0 9.96081 10.7142 0 0 0 0 0 10.088 0 P0C7U3 ZH11B_HUMAN Probable palmitoyltransferase ZDHHC11B (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11B) (DHHC-11B) ZDHHC11B Homo sapiens (Human) antiviral innate immune response [GO:0140374]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] protein-cysteine S-palmitoyltransferase activity [GO:0019706] TDPRYEDVK 1 2.4 0.90154 -0.26229 10.588 0 0 0 0 0 0 0 0 0 0 0 P0C7U9 FA87A_HUMAN Protein FAM87A FAM87A Homo sapiens (Human) membrane [GO:0016020] AVVTRTVTKAQSLK 1 4.9 0.96202 -1.0692 0 0 0 0 0 0 12.4774 0 0 0 13.6418 0 P0C7V4 F90AF_HUMAN Protein FAM90A15 FAM90A15 FAM90A15P Homo sapiens (Human) EPLLVVKPTHSRPEGGCREVPQAASK;GEKEERPR 2 7.3 0.98025 -2.009 11.3912 0 0 0 0 0 0 0 0 0 0 7.35006 P0C7V6 SP202_HUMAN Putative transcription factor SPT20 homolog-like 2 SUPT20HL2 FAM48B2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] extracellular space [GO:0005615]; SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] VGQPCELNITK 1 1.3 0.71604 0.13812 0 0 0 0 0 0 0 0 0 10.2594 10.2975 0 P0C7X3 CCYL3_HUMAN Putative cyclin-Y-like protein 3 CCNYL3 Homo sapiens (Human) regulation of canonical Wnt signaling pathway [GO:0060828] plasma membrane [GO:0005886] ISGTCRNHFAGMQK;KIVLGTMLLASKVWR 2 8.4 0.89721 -0.23187 0 0 0 0 8.96601 0 0 0 0 0 6.89178 0 P0C854 CECR9_HUMAN Putative cat eye syndrome critical region protein 9 CECR9 Homo sapiens (Human) extracellular region [GO:0005576] AGGSCQAAQPEDR 1 6 0.80898 0.010788 0 0 0 0 0 0 0 0 2.16392 0 0 0 P0C860 MS3L2_HUMAN MSL complex subunit 3B (Male-specific lethal-3 homolog 2) (Male-specific lethal-3 homolog pseudogene 1) (Male-specific lethal-3 protein-like 2) (MSL3-like 2) MSL3B MSL3L2 MSL3P1 Homo sapiens (Human) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634] NLKALLKHFDLFVR;NPQAVNK;QLEDDCYYINR 3 9 0.9645 -1.1644 0 0 0 0 7.73132 0 0 0 0 0 0 0 P0C862 C1T9A_HUMAN Complement C1q and tumor necrosis factor-related protein 9A (Complement C1q and tumor necrosis factor-related protein 9) C1QTNF9 C1QTNF9A UNQ6503/PRO21380 Homo sapiens (Human) collagen trimer [GO:0005581]; extracellular region [GO:0005576] hormone activity [GO:0005179]; identical protein binding [GO:0042802] GIKGDQGSRGSPGK;GLAGPMGEK 2 6.9 0.34155 0.23865 0 0 0 8.33324 0 8.72288 0 0 0 0 0 0 P0C864 DANCR_HUMAN Putative uncharacterized protein DANCR (Anti-differentiation ncRNA protein) (Differentiation antagonizing non-protein coding RNA) (Small nucleolar RNA host gene protein 13) DANCR ANCR KIAA0114 SNHG13 Homo sapiens (Human) LSGLCARR 1 4.9 0.909 -0.31398 0 0 0 0 0 0 0 0 0 0 10.9832 0 P0C869 PA24B_HUMAN Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Lysophospholipase A1 group IVB) (EC 3.1.1.5) (Phospholipase A2 group IVB) PLA2G4B Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] DVDLILSLEALRQAVQR;WSLPYFR 2 2.7 0.91514 -0.33083 0 0 0 0 0 0 0 10.7006 0 0 9.68046 0 P0C875 F228B_HUMAN Protein FAM228B FAM228B Homo sapiens (Human) RWVDCVADPLQKK 1 4 0.71203 0.15172 0 0 0 0 0 0 0 0 0 0 0 9.93078 P0C879 YJ018_HUMAN Putative uncharacterized protein FLJ43185 Homo sapiens (Human) AGPRPFPTPR 1 7.2 0.93093 -0.48945 0 12.2157 0 0 0 0 0 0 0 0 0 0 P0C8F1 PATE4_HUMAN Prostate and testis expressed protein 4 (PATE-like protein B) (PATE-B) PATE4 Homo sapiens (Human) regulation of neurotransmitter receptor activity [GO:0099601] acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615] acetylcholine receptor regulator activity [GO:0030548] ENELCSTTAYFR 1 12.2 0.80678 0.011956 5.93911 0 0 0 0 0 0 0 0 0 0 0 P0CAP1 MYZAP_HUMAN Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) MYZAP MYOZAP Homo sapiens (Human) intracellular signal transduction [GO:0035556] "anchoring junction [GO:0070161]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; I band [GO:0031674]; RNA polymerase II, core complex [GO:0005665]; Z disc [GO:0030018]" MYGDYDEMR;VKQMVEEIESLK 2 4.5 0.93671 -0.52503 0 0 0 0 4.90265 0 0 0 0 8.47391 0 0 P0CAP2 GRL1A_HUMAN DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) POLR2M GRINL1A Homo sapiens (Human) maintenance of ER location [GO:0051685]; transcription elongation by RNA polymerase II [GO:0006368] "I band [GO:0031674]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; RNA polymerase II, core complex [GO:0005665]; transcription preinitiation complex [GO:0097550]" RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711] SSMNLLSLAAAAK 1 3.6 0.27683 0.25421 8.24755 5.2431 0 0 0 0 0 0 0 0 0 0 P0CB48 UBFL6_HUMAN Putative upstream-binding factor 1-like protein 6 UBTFL6 Homo sapiens (Human) positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360] nucleus [GO:0005634] RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181] CVKNTNK;DIKVALPR;FSTLKKLVLEAK;ILSKKYK;NIEEVRSLPKTDQFFK;VQKNIEEVR 6 13.2 0.97862 -6.8018 0 0 0 8.65585 0 5.00984 10.6817 0 9.70113 9.29685 0 0 P0CE67 CC079_HUMAN Putative uncharacterized protein encoded by LINC02877 LINC02877 C3orf79 Homo sapiens (Human) TSGCLTQMPILYGHPATLLKDYILQAILQPGK 1 32 0.92526 -0.45114 0 0 0 0 0 0 0 0 0 0 10.732 0 P0CF75 EBLN1_HUMAN Endogenous Bornavirus-like nucleoprotein 1 (Endogenous Borna-like N element-1) (EBLN-1) EBLN1 Homo sapiens (Human) VLGDFFEFGGVLR 1 3.6 0.78398 0.018686 0 12.5409 0 0 0 0 0 0 0 0 0 0 P0CF97 F200B_HUMAN Protein FAM200B FAM200B C4orf53 Homo sapiens (Human) EIPQNLMEVLK;FETLRENSWVKDPFAFR;IANTAAEK;VYELRNEIHFFLIEK 4 7.8 0.98072 -1.7494 0 0 0 0 0 0 0 0 0 4.74932 0 8.24017 P0CG00 ZSA5D_HUMAN Putative zinc finger and SCAN domain-containing protein 5D (Zinc finger and SCAN domain-containing protein 5D pseudogene) ZSCAN5DP ZSCAN5D Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALRPKPTLEK;VHQRIHTGEKPYTCDICHK 2 5.8 0.95082 -0.66665 0 0 0 0 0 0 0 0 0 0 5.89259 9.28207 P0CG08 GPHRB_HUMAN Golgi pH regulator B (Protein GPR89B) GPR89B GPHR GPR89 GPR89C SH120 HSPC201 Homo sapiens (Human) intracellular pH reduction [GO:0051452]; protein transport [GO:0015031]; T cell differentiation [GO:0030217] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; monoatomic ion channel complex [GO:0034702] voltage-gated monoatomic anion channel activity [GO:0008308] GLLITLTKFFYAISSSK;TIITEVLGELQFNFYHR 2 7.5 0.80471 0.012495 11.5735 0 0 0 0 0 0 0 0 0 0 0 P0CG12 DERPC_HUMAN Decreased expression in renal and prostate cancer protein DERPC Homo sapiens (Human) extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] GAGSSAFSQSSGTLASNPATFQRSAGLQGSNPTIFPR;MNGPAGK 2 8.4 0.81222 0.0025912 0 0 0 5.68218 0 0 0 0 0 10.1876 0 0 P0CG20 PRR35_HUMAN Proline-rich protein 35 (Uncharacterized protein RJD1) PRR35 C16orf11 Homo sapiens (Human) ALGDYAR;EAGSCRVGTGAR;EAGSCRVGTGARAR 3 3.7 0.96316 -1.0831 0 0 0 0 0 0 9.03023 0 6.96359 4.061 0 10.7661 P0CG22 DR4L1_HUMAN Putative dehydrogenase/reductase SDR family member 4-like 1 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 25C member 4) (Protein SDR25C4) DHRS4L1 SDR25C4 Homo sapiens (Human) retinal metabolic process [GO:0042574] peroxisome [GO:0005777] carbonyl reductase (NADPH) activity [GO:0004090] LVATAMK 1 2.5 0.9147 -0.33017 0 0 0 0 0 7.77571 0 8.4149 0 0 0 0 P0CG23 ZN853_HUMAN Zinc finger protein 853 ZNF853 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QELERQQELER 1 1.7 0.88506 -0.18131 0 0 0 0 0 0 0 0 0 0 0 8.88853 P0CG24 ZN883_HUMAN Zinc finger protein 883 ZNF883 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" STHLIEHQGIHSEEK 1 4 0.784 0.023877 8.22612 0 0 0 8.39498 0 0 0 0 0 0 0 P0CG30 GSTT2_HUMAN Glutathione S-transferase theta-2B (EC 2.5.1.18) (Glutathione S-transferase theta-2) (GST class-theta-2) GSTT2B GSTT2 Homo sapiens (Human) glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] glutathione transferase activity [GO:0004364] GLELFLDLVSQPSRAVYIFAK;TLPTPSPEAYQAMLLR 2 15.2 0.91552 -0.37341 0 0 0 11.6049 0 0 13.7536 0 12.3243 11.4914 12.91 0 P0CG42 F157B_HUMAN Putative protein FAM157B FAM157B Homo sapiens (Human) QQQQQQQQQQQQLDLLFHQR 1 5.2 0.78315 0.025586 0 0 0 0 7.41667 0 0 0 8.00191 0 0 0 P0CG43 F157C_HUMAN Putative protein FAM157C FAM157C Homo sapiens (Human) KTEQHSHSFVK;LLHDLHLLAFPTKCIWIHRR 2 8 0.95292 -0.67834 0 0 0 0 0 0 0 0 0 5.44367 0 0 P0CJ77 HMN10_HUMAN Humanin-like 10 (HN10) (MT-RNR2-like protein 10) MTRNR2L10 Homo sapiens (Human) negative regulation of execution phase of apoptosis [GO:1900118] cytoplasm [GO:0005737]; extracellular region [GO:0005576] receptor antagonist activity [GO:0048019] GFSCLLLLIREIDLSAKR 1 75 0.86444 -0.086176 0 0 0 0 0 0 0 0 0 0 9.89779 0 P0CJ78 ZN865_HUMAN Zinc finger protein 865 ZNF865 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] FPCGVCQK;RFPCGVCQKSFK;TYNHVSSLIRHR 3 2.3 0.97663 -2.2452 0 0 0 0 0 0 0 0 10.9226 0 9.18421 11.0245 P0CJ79 ZN888_HUMAN Zinc finger protein 888 ZNF888 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFKCYSHLAQHTR;SFNHKSSLAYHHRLHTGEKPYK;SINNASSVSTSQR;TLYRDVMLENYR;VIHTGEK 5 10.3 0.90179 -0.26358 0 0 0 0 9.35872 6.99027 0 0 0 0 0 0 P0CJ92 GOG8H_HUMAN Golgin subfamily A member 8H GOLGA8H Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] LNTDLYHMK;NQRISLLNQRQEER;TEWKLEQSMR;VAGELQAQVKKNQR 4 7 0.97889 -2.1109 13.7776 0 0 0 0 0 0 9.82939 0 2.55888 0 8.57448 P0CK96 S352B_HUMAN Solute carrier family 35 member E2B SLC35E2B KIAA0447 Homo sapiens (Human) blastocyst hatching [GO:0001835]; transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297] APDDTVEPLLPQDPR;LLSGDKYR 2 5.7 0.92878 -0.4629 0 0 0 0 0 9.94993 0 0 0 6.90533 0 0 P0CL83 ST3L1_HUMAN Putative STAG3-like protein 1 (Stromal antigen 3-like protein 1) STAG3L1 Homo sapiens (Human) nucleus [GO:0005634] DLTARLELFTGRFK;LELFTGRFK;LLILILK;YIGWTLHDKHR 4 15.6 0.97342 -2.895 0 0 0 11.3491 0 0 0 0 0 0 0 0 P0CL85 ST3L3_HUMAN STAG3-like protein 3 (Stromal antigen 3-like protein 3) STAG3L3 Homo sapiens (Human) nucleus [GO:0005634] LELFTGCFK;LLILILK;YIGWTLHDKHR 3 20.1 0.84632 -0.065226 0 0 0 0 0 0 0 6.18533 0 0 0 0 P0CW19 LIMS3_HUMAN LIM and senescent cell antigen-like-containing domain protein 3 (Particularly interesting new Cys-His protein 3) (PINCH-3) LIMS3 PINCH3 Homo sapiens (Human) cytoplasm [GO:0005737]; focal adhesion [GO:0005925] metal ion binding [GO:0046872] GLGKYICQK;NDPYHPDHFNCANCGQEGSDCR 2 12.5 0.78801 0.017575 6.13395 0 0 0 0 0 0 0 0 0 0 0 P0CW24 PNM6A_HUMAN Paraneoplastic antigen-like protein 6A PNMA6A PNMA6C Homo sapiens (Human) AVTMLQDWCRWMGVNARR;EVNYALVPR;LRQMLTRAHLTEPLDEALR 3 11.5 0.97869 -2.1086 0 9.31467 0 0 0 0 9.11022 4.97943 0 0 0 0 P0CW27 CC166_HUMAN Coiled-coil domain-containing protein 166 CCDC166 Homo sapiens (Human) LLSGLSR 1 1.6 0.9089 -0.30957 0 0 0 0 0 0 0 0 0 9.87332 0 0 P0DH78 RN224_HUMAN RING finger protein 224 RNF224 Homo sapiens (Human) metal ion binding [GO:0046872] RLYCGHTFCQACVR 1 9 0.73543 0.11131 0 0 0 0 0 0 8.34341 0 0 0 0 0 P0DI83 NARR_HUMAN "Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats)" RAB34 NARR Homo sapiens (Human) nucleolus [GO:0005730] AEGSRPGGAAPVPEEGGRFAR;VGQPQPR;VIVGTIRPRVIVGTIRPRVIVGSAR;VVVGTPRPRVIVGSPR 4 34.8 0.95696 -0.84894 0 0 6.73512 10.2211 11.2555 0 0 0 0 9.25988 7.92529 0 P0DJD0 RGPD1_HUMAN RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) RGPD1 RANBP2L6 RGP1 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] AVVSPPK;DLVLKIAELLCK;DVGQWKER;EVVETFANK;GEAGQNLLEMMACDR;KCELSKNSDIEQSSDSK;LCTERQKSWWDAVCTLIHR;QKSWWDAVCTLIHR;STKEGFSIAVSADGFKFGISEPGNQEK;SVMQELEDYSEGGPLYKNGSLR;VLPLLKIIK;YSLSPSKSYK 12 8.9 0.9168 -0.36203 12.8849 0 9.67987 0 0 0 0 0 0 0 0 7.76818 P0DJD3 RBY1A_HUMAN "RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)" RBMY1A1 RBM1 RBM2 YRRM1 YRRM2 Homo sapiens (Human) "mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729]; RNA binding [GO:0003723] DYGHSSWDEHSSR;EHVCRKDQR;MSYGGSTCHAYSNTR;SGGPPPK 4 8.9 0.97546 -1.4726 5.73406 0 2.4194 7.17003 0 0 0 0 0 0 0 0 P0DJG4 SMA2L_HUMAN Sperm microtubule associated protein 2-like (Testicular haploid expressed gene protein-like) (Theg spermatid-like protein) SPMAP2L THEGL Homo sapiens (Human) IQELANPNKRAPVR 1 3 0.85668 -0.081065 0 0 0 0 0 0 0 0 7.02436 0 0 0 P0DJH9 RD3L_HUMAN Protein RD3-like (Retinal degeneration protein 3-like) RD3L Homo sapiens (Human) QVLKDFLSSSDR;WHLKERER 2 10.1 0.97931 -1.8954 11.0922 0 10.8227 0 0 0 0 0 8.81737 0 0 0 P0DKB5 TPBGL_HUMAN Trophoblast glycoprotein-like TPBGL Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090] plasma membrane [GO:0005886] APAPAAPAGSRATSPGSGL 1 5 0.93705 -0.56125 0 12.291 0 0 0 0 0 0 0 0 0 0 P0DKX0 ZN728_HUMAN Zinc finger protein 728 ZNF728 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHAGEK;CEECGKAFSKFSILTK;IRHTGKK;VFSWSSSLTTHK;VIHTGEK 5 11.3 0.9776 -2.1344 5.15076 0 0 0 0 9.05162 0 0 0 0 8.78529 0 P0DKX4 SIM18_HUMAN Small integral membrane protein 18 SMIM18 Homo sapiens (Human) membrane [GO:0016020] DLKSEPNPLRSMMDNIR 1 17.9 0.84861 -0.076669 10.5486 0 0 0 0 0 0 0 0 0 0 0 P0DM35 M1BL1_HUMAN Metallothionein 1H-like protein 1 MT1HL1 Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] DPNCSCAAGGSYACAGSCK;DPNCSCAAGGSYACAGSCKCK;MDPNCSCAAGGSYACAGSCK;MDPNCSCAAGGSYACAGSCKCK;SCCSCCPLGCAK 5 55.7 0.87588 -0.1214 0 4.41224 0 0 4.77726 0 9.54205 0 9.24691 0 0 0 P0DME0 SETLP_HUMAN Protein SETSIP (SET pseudogene protein 18) (SET similar protein) (Similar to SET translocation protein) SETSIP SETP18 Homo sapiens (Human) endothelial cell differentiation [GO:0045446]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] EFHLNESGDPSSK;LNEQDSEEILKVEQK;VEVTEFEDIK 3 13 0.9525 -0.68043 0 0 0 0 0 0 0 0 12.5574 0 0 0 P0DMQ5 INAM2_HUMAN Putative transmembrane protein INAFM2 (InaF-motif-containing protein 2) (Osteogenesis up-regulated transcript 1) INAFM2 LINC00984 OGU1 Homo sapiens (Human) membrane [GO:0016020] KERDAAPAER 1 6.5 0.97525 -1.4582 0 0 0 0 0 0 0 0 0 13.993 0 0 P0DMQ9 CH089_HUMAN Putative uncharacterized protein C8orf89 C8orf89 Homo sapiens (Human) ETCSVAPLWEK 1 6.8 0.72778 0.12568 0 0 0 0 0 0 0 0 10.9912 0 0 10.879 P0DMS9 TMIG3_HUMAN Transmembrane domain-containing protein TMIGD3 TMIGD3 UNQ1931/PRO4406 Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of heart contraction [GO:0008016]; regulation of innate immune response [GO:0045088]; response to wounding [GO:0009611]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] TSILIICILITGLGIISVISHLTKR 1 9.4 0.37013 0.22753 0 3.87096 0 0 0 0 0 0 5.65935 0 0 0 P0DMT0 MLN_HUMAN Myoregulin MRLN MLN Homo sapiens (Human) negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081] sarcoplasmic reticulum membrane [GO:0033017] enzyme inhibitor activity [GO:0004857] TGKNWILISTTTPK 1 30.4 0.83248 -0.028128 0 0 0 0 0 0 0 7.61919 0 0 0 0 P0DMU3 F231L_HUMAN FAM231A/C-like protein LOC102723383 Homo sapiens (Human) ASREEGTFWTER 1 7.1 0.95131 -0.68923 0 0 0 0 0 10.487 0 0 0 0 0 0 P0DMV8 HS71A_HUMAN Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) HSPA1A HSP72 HSPA1 HSX70 Homo sapiens (Human) ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; lysosomal transport [GO:0007041]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of endoribonuclease activity [GO:1902380]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of RNA splicing [GO:0033120]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986] aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; death receptor agonist activity [GO:0038177]; denatured protein binding [GO:0031249]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; misfolded protein binding [GO:0051787]; protein folding chaperone [GO:0044183]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618] AFYPEEISSMVLTK;ATAGDTHLGGEDFDNR;DAGVIAGLNVLR;DNNLLGR;GGSGSGPTIEEVD;IINEPTAAAIAYGLDR;ITITNDK;ITITNDKGR;LDKAQIHDLVLVGGSTR;LLQDFFNGRDLNK;LSKEEIER;LVNHFVEEFKR;MVQEAEK;NALESYAFNMK;NQVALNPQNTVFDAK;NQVALNPQNTVFDAKR;NSTIPTK;SAVEDEGLK;STLEPVEK;TACERAK;TTPSYVAFTDTER;TTPSYVAFTDTERLIGDAAK;YKAEDEVQR 23 35.9 0 77.515 14.0131 12.9372 13.6307 10.9776 11.1657 10.3065 15.4795 14.8602 14.9724 15.0257 14.8375 13.6494 P0DN25 C1C1L_HUMAN C1GALT1-specific chaperone 1-like protein C1GALT1C1L Homo sapiens (Human) membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] ETWTKHCDK;GQTQDHEHHHLRPPNR;WVQMRTAYKYVFEK 3 12.4 0.96671 -1.2655 0 0 0 0 0 3.92752 0 0 0 0 0 12.0296 P0DO97 CC192_HUMAN Coiled-coil domain-containing protein 192 CCDC192 LINC01183 Homo sapiens (Human) LEAVDHK 1 2.4 0.9367 -0.52493 0 0 0 0 0 0 0 12.3417 0 0 0 12.2146 P0DOX2 IGA2_HUMAN Immunoglobulin alpha-2 heavy chain (Immunoglobulin alpha-2 heavy chain BUT) Homo sapiens (Human) adaptive immune response [GO:0002250] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] LFGKGTTVTVSSASPTSPK 1 4.2 0.82523 -0.020545 0 0 0 0 0 0 0 0 0 0 0 7.63416 P0DOX3 IGD_HUMAN Immunoglobulin delta heavy chain (Immunoglobulin delta heavy chain WAH) Homo sapiens (Human) adaptive immune response [GO:0002250]; monocyte activation [GO:0042117]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760] extracellular space [GO:0005615]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] DKATFTCFVVGSDLK;GRVTISVDTSR;LQLQESGPGLVKPSETLSLTCIVSGGPIRR 3 10.9 0.96433 -1.2228 10.9351 0 0 0 0 0 7.23802 0 0 0 0 11.1706 P0DOX5 IGG1_HUMAN Immunoglobulin gamma-1 heavy chain (Immunoglobulin gamma-1 heavy chain NIE) Homo sapiens (Human) adaptive immune response [GO:0002250] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] QVQLVQSGGGVVQPGR;WQQGNVFSCSVMHEALHNHYTQK 2 8.7 0.91026 -0.29955 0 0 0 11.7508 0 0 0 0 0 0 0 0 P0DP07 HV431_HUMAN Immunoglobulin heavy variable 4-31 IGHV4-31 Homo sapiens (Human) immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] SLVTISVDTSKNQFSLK 1 14.4 0.94132 -0.60069 0 0 0 9.32775 0 9.65726 0 0 10.9957 0 0 0 P0DP09 KV113_HUMAN Immunoglobulin kappa variable 1-13 IGKV1-13 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] LLIYDASSLESGVPSR;VPAQLLGLLLLWLPGAR 2 28.2 0.77302 0.050868 0 0 9.14415 0 0 0 0 0 0 0 0 0 P0DP25 CALM3_HUMAN Calmodulin-3 CALM3 CALML2 CAM3 CAMC CAMIII Homo sapiens (Human) calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; presynaptic endocytosis [GO:0140238]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762] calcium channel complex [GO:0034704]; calyx of Held [GO:0044305]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] adenylate cyclase activator activity [GO:0010856]; adenylate cyclase binding [GO:0008179]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325] ADQLTEEQIAEFK;MKDTDSEEEIREAFR 2 18.8 0.74539 0.096379 0 0 0 0 0 0 0 0 0 10.1325 7.84292 0 P0DP72 VSXL2_HUMAN V-set and immunoglobulin domain-containing protein 10-like 2 VSIG10L2 Homo sapiens (Human) cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] EEVTLSCLAASNPPSHYVWLR;VGQRAQHSPVSLLLLIHLCLLHLR 2 5.9 0.90802 -0.27505 0 10.364 0 0 0 0 0 0 0 0 6.87701 0 P0DP74 D130A_HUMAN "Beta-defensin 130A (Beta-defensin 130) (Beta-defensin 30) (DEFB-30) (Defensin, beta 130)" DEFB130A DEFB130 DEFB30 Homo sapiens (Human) cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742] extracellular space [GO:0005615] CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056] LHSLISVLLLFVTLIPK;MKLHSLISVLLLFVTLIPKGK 2 26.6 0.13623 0.35436 0 0 0 0 0 4.79665 4.43523 0 0 8.76861 0 0 P0DP91 ERPG3_HUMAN Chimeric ERCC6-PGBD3 protein (Chimeric CSB-PGBD3 protein) ERCC6 Homo sapiens (Human) positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] sequence-specific DNA binding [GO:0043565] FSKLRPLISKLNER;LDSVKRQK;SVGDGLSTSAVGCASAAPRR;WKKADLTVQPVAGR 4 5.3 0.8331 -0.027709 0 0 10.9346 3.52394 5.19117 0 0 0 0 0 0 0 P0DPA2 VSIG8_HUMAN V-set and immunoglobulin domain-containing protein 8 VSIG8 C1orf204 Homo sapiens (Human) membrane [GO:0016020] RNA binding [GO:0003723] SAEPADCAEGPVQCK;SAEPADCAEGPVQCKNGLLV 2 4.8 0.88194 -0.16748 0 0 0 0 0 7.51877 5.84207 0 0 0 0 0 P0DPB3 SCHI1_HUMAN Schwannomin-interacting protein 1 (SCHIP-1) SCHIP1 Homo sapiens (Human) positive regulation of hippo signaling [GO:0035332] cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] HSDSDYREDGMDLGSDAGSSSSSSR 1 5.3 0.83801 -0.039211 0 0 0 0 0 0 0 0 0 0 0 5.91602 P0DPB6 RPAC2_HUMAN DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19) POLR1D Homo sapiens (Human) transcription by RNA polymerase III [GO:0006383]; transcription elongation by RNA polymerase I [GO:0006362] RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983] KISGLKTSMAEGER 1 10.5 0.97603 -1.4757 0 0 0 8.37673 0 0 0 0 0 0 0 0 P0DPD5 ZN723_HUMAN Zinc finger protein 723 ZNF723 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGYDELKQCLTTTPSKIFQCDK 1 4.3 0.56138 0.18276 0 0 10.2133 0 0 0 0 0 0 0 0 0 P0DPD6 ECE2_HUMAN Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71) ECE2 KIAA0604 UNQ403/PRO740 Homo sapiens (Human) cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; methylation [GO:0032259]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485] cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; methyltransferase activity [GO:0008168] GVSPCEDFYQFSCGGWIR;NVALQELGAGSNMVEYK 2 4.6 0.41945 0.1984 0 0 11.5029 0 0 0 9.75027 0 0 0 0 0 P0DPI3 CENL2_HUMAN Centromere protein V-like protein 2 (Centromere protein V pseudogene 2) CENPVL2 CENPVP2 Homo sapiens (Human) carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] VLLDTFEYPGLVHHTGGCHCGAVR 1 8.8 0.71045 0.15634 0 0 0 0 0 0 0 0 0 7.22294 0 0 P0DSE2 TRBR1_HUMAN M1-specific T cell receptor beta chain (TR beta chain TRBV19*01J2S7*01C*02) TRB Homo sapiens (Human) adaptive immune response [GO:0002250]; T cell activation involved in immune response [GO:0002286] cell surface [GO:0009986]; T cell receptor complex [GO:0042101] EQPALNDSRYCLSSR;GDIAEGYSVSREK 2 9 0.88716 -0.18571 0 0 0 0 0 0 0 0 0 0 8.08406 0 P0DSO1 F246C_HUMAN Protein FAM246C FAM246C Homo sapiens (Human) CQCRLGPR 1 3.3 0.91341 -0.33804 0 0 9.99901 0 0 0 0 0 0 0 0 0 P0DSO2 SCGR9_HUMAN Small cysteine and glycine repeat-containing protein 9 (Keratin-associated protein 28-1 pseudogene) SCYGR9 KRTAP28p1 Homo sapiens (Human) intermediate filament [GO:0005882] CYRVGCCSSCCPCCR;GCCGGCCSTPVICCCR;RTCSSCGCGCGK;RTCSSCGCGCGKGCCQQK;TCSSCGCGCGKGCCQQK;TCSSCGCGCGKGCCQQKSCCQK 6 58.7 0.044326 0.50356 3.97526 0 0 4.22512 0 4.9428 0 0 4.45917 5.07801 0 0 P0DTE4 UD2A1_HUMAN UDP-glucuronosyltransferase 2A1 (UDPGT 2A1) (UGT2A1) (EC 2.4.1.17) UGT2A1 Homo sapiens (Human) bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608] endoplasmic reticulum membrane [GO:0005789] glucuronosyltransferase activity [GO:0015020] FSPASTVER 1 1.3 0.90711 -0.30433 0 0 0 0 0 0 0 11.2219 0 0 0 0 P0DTL4 LY6S_HUMAN Lymphocyte antigen 6S LY6S Homo sapiens (Human) plasma membrane [GO:0005886]; side of membrane [GO:0098552] VSVFGSK 1 5.2 0.90903 -0.31529 0 0 0 0 0 0 0 7.4358 0 0 0 0 P0DTU4 TRBR2_HUMAN T cell receptor beta chain MC.7.G5 (TR beta chain TRBV25-1*01J2S3*01C2*01) (MC.7.G5 TRB) TRB Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; detection of tumor cell [GO:0002355]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419] alpha-beta T cell receptor complex [GO:0042105]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] EQPALNDSRYCLSSR;GLAEFTDTQYFGPGTR 2 9.8 0.79638 0.015086 9.16232 0 0 0 6.34053 0 0 0 0 0 0 0 P0DUX1 SPD12_HUMAN Speedy protein E12 SPDYE12 SPDYE12P Homo sapiens (Human) protein kinase binding [GO:0019901] ELWFQLCR;SHIPLLRELWFQLCRYMNPR 2 7.5 0.98113 -1.593 0 0 11.9599 0 0 9.98456 0 0 0 11.6273 0 0 P0DV60 LCE7A_HUMAN Late cornified envelope protein 7A LCE7A Homo sapiens (Human) keratinization [GO:0031424] CSTCYSSGDCS 1 11.6 0.89531 -0.24267 0 0 0 0 0 0 0 0 4.24047 0 0 0 P0DV77 TPRX2_HUMAN Tetrapeptide repeat homeobox protein 2 TPRX2 Homo sapiens (Human) maternal-to-zygotic transition of gene expression [GO:0160021] nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" TVYTESQQK;VLEFYFQK 2 5.6 0.9653 -1.1351 0 0 0 0 0 0 0 0 0 9.98071 0 0 P0DW14 TFKLJ_HUMAN TATA-box-binding protein-associated factor 11-like protein 10 TAF11L10 Homo sapiens (Human) RNA polymerase II preinitiation complex assembly [GO:0051123] transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982] EAVRRLKPK;GLKGSKK 2 8.1 0.97254 -1.3654 0 0 0 0 9.87624 0 0 7.76182 0 0 0 0 P0DW85 H2BN1_HUMAN Histone H2A.N (H2B.N) (H2B.N variant histone 1) H2BN1 Homo sapiens (Human) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] FPKNKTELYFPVK;KHEWANSATGKK 2 21.2 0.83686 -0.033252 0 0 9.68513 0 0 0 0 0 0 9.23096 0 0 P10070 GLI2_HUMAN Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) GLI2 THP Homo sapiens (Human) axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cellular response to virus [GO:0098586]; cerebellar cortex morphogenesis [GO:0021696]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; epidermal cell differentiation [GO:0009913]; floor plate formation [GO:0021508]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; kidney development [GO:0001822]; lung development [GO:0030324]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; pituitary gland development [GO:0021983]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord ventral commissure morphogenesis [GO:0021965]; tube development [GO:0035295]; ventral midline development [GO:0007418]; ventral spinal cord development [GO:0021517] ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" KEFVCRWQACTR 1 0.8 0.87056 -0.096026 0 0 0 6.91803 0 0 0 0 0 0 0 0 P10071 GLI3_HUMAN Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] GLI3 Homo sapiens (Human) alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; nose morphogenesis [GO:0043585]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625] axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" CTFEGCTKAYSR;QPVAPGALDGACGAGIQASK 2 2 0.94456 -0.63759 0 0 0 0 11.1891 11.2337 0 0 0 0 9.23439 0 P10072 ZN875_HUMAN Zinc finger protein 875 (Krueppel-related zinc finger protein 1) (Protein HKR1) ZNF875 HKR1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" GFTWKSNLFTHQR;HQRTHSGEKPYICRK 2 4.2 0.98035 -1.8063 0 0 0 0 0 0 0 0 0 0 0 12.1875 P10074 TZAP_HUMAN Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855) ZBTB48 HKR3 TZAP ZNF855 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" DNA-binding transcription factor activity [GO:0003700]; double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976] DLQSHMIK;FECTECGYKFTRQAHLR;GPLLRHVASR;NLIIEDEK 4 6.2 0.97218 -2.691 0 0 0 8.74819 0 7.86338 0 0 0 0 7.68867 0 P10109 ADX_HUMAN "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)" FDX1 ADX Homo sapiens (Human) cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; electron transport chain [GO:0022900]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; steroid biosynthetic process [GO:0006694] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]" SLSVSAR;WLHHAGSR 2 8.2 0.95512 -0.80578 0 9.26158 0 0 0 8.79038 0 0 7.97585 12.914 0 0 P10124 SRGN_HUMAN Serglycin (Hematopoietic proteoglycan core protein) (Platelet proteoglycan core protein) (P.PG) (Secretory granule proteoglycan core protein) SRGN PRG PRG1 Homo sapiens (Human) apoptotic process [GO:0006915]; biomineral tissue development [GO:0031214]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; maintenance of granzyme B location in T cell secretory granule [GO:0033382]; maintenance of protease location in mast cell secretory granule [GO:0033373]; mast cell secretory granule organization [GO:0033364]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine production [GO:0001818]; protein processing [GO:0016485]; secretory granule organization [GO:0033363]; T cell secretory granule organization [GO:0033371] cytolytic granule [GO:0044194]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mast cell granule [GO:0042629]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141] IPRLRTDLFPK 1 7 0.76982 0.056226 0 0 0 0 0 0 0 0 0 0 3.13914 0 P10147 CCL3_HUMAN C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))] CCL3 G0S19-1 MIP1A SCYA3 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; astrocyte cell migration [GO:0043615]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; MAPK cascade [GO:0000165]; monocyte chemotaxis [GO:0002548]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; neutrophil chemotaxis [GO:0030593]; osteoblast differentiation [GO:0001649]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of behavior [GO:0050795]; regulation of cell shape [GO:0008360]; regulation of sensory perception of pain [GO:0051930]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; response to toxic substance [GO:0009636]; signaling [GO:0023052]; T cell chemotaxis [GO:0010818] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR1 chemokine receptor binding [GO:0031726]; CCR5 chemokine receptor binding [GO:0031730]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672] RSRQVCADPSEEWVQK 1 17.4 0.95532 -0.97858 0 0 0 0 0 0 0 0 0 10.2692 10.8827 0 P10155 RO60_HUMAN RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) RO60 SSA2 TROVE2 Homo sapiens (Human) cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620] EQKLGLENAEALIR;FLCFGSEGGTYYIK;LKWRPDEEILK;LVREHLLTNHLK 4 9.5 0.98034 -2.0377 0 0 0 6.58966 11.3327 8.77132 8.5716 0 0 0 0 0 P10176 COX8A_HUMAN "Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2)" COX8A COX8 COX8L Homo sapiens (Human) "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129] SVLTPLLLRGLTGSARR 1 24.6 0.76365 0.065999 0 0 0 0 0 0 0 0 0 3.13266 0 0 P10242 MYB_HUMAN Transcriptional activator Myb (Proto-oncogene c-Myb) MYB Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; erythrocyte differentiation [GO:0030218]; mitotic cell cycle [GO:0000278]; myeloid cell development [GO:0061515]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; skeletal muscle cell proliferation [GO:0014856]; T-helper 2 cell differentiation [GO:0045064] cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASQPAVATSFQK;FSCLSLPR;ITGVSHR;VIANYLPNR;WSVIAKHLK 5 6.8 0.97312 -2.562 0 0 3.5541 0 0 0 11.1335 0 8.32688 0 0 0 P10242 MYB_HUMAN Transcriptional activator Myb (Proto-oncogene c-Myb) MYB Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; erythrocyte differentiation [GO:0030218]; mitotic cell cycle [GO:0000278]; myeloid cell development [GO:0061515]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; skeletal muscle cell proliferation [GO:0014856]; T-helper 2 cell differentiation [GO:0045064] cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASQPAVATSFQK;VIANYLPNR;VLPPARHSTIPLVILRK;WSVIAKHLK 4 6.3 0.52393 0.18668 0 0 0 6.77017 0 0 0 0 0 0 0 0 P10243 MYBA_HUMAN Myb-related protein A (A-Myb) (Myb-like protein 1) MYBL1 AMYB Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of piRNA transcription [GO:0140543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatogenesis [GO:0007283] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NLQSNCEWETVVYGK;QDINSTNKTYTLTKK 2 4 0.74488 0.092284 0 0 2.72775 0 0 0 0 5.76487 0 0 7.43912 0 P10244 MYBB_HUMAN Myb-related protein B (B-Myb) (Myb-like protein 2) MYBL2 BMYB Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" QWTLIAKHLK;SLALDIVDEDVK;VLNPDLVK 3 4.3 0.97945 -1.897 0 0 4.97021 0 10.0769 0 0 14.1434 0 14.5941 14.3976 11.5267 P10253 LYAG_HUMAN Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] GAA Homo sapiens (Human) aorta development [GO:0035904]; cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maltose metabolic process [GO:0000023]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; sucrose metabolic process [GO:0005985]; tissue development [GO:0009888]; vacuolar sequestering [GO:0043181] autolysosome lumen [GO:0120282]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] "alpha-1,4-glucosidase activity [GO:0004558]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]" LENLSSSEMGYTATLTR 1 1.8 0.78332 0.030116 0 0 0 0 0 0 0 0 9.77434 0 0 0 P10275 ANDR_HUMAN Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR DHTR NR3C4 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular receptor signaling pathway [GO:0030522]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" ILSGKVKPIYFHTQ;RAAEGKQK;RFYQLTK;VYPRPPSK;VYPRPPSKTYRGAFQNLFQSVR 5 5.5 0.95594 -0.98751 0 0 0 0 0 0 9.41859 9.73551 0 9.94708 5.13902 0 P10275 ANDR_HUMAN Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR DHTR NR3C4 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular receptor signaling pathway [GO:0030522]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" RAAEGKQK;VGNCKHLKMTRP;VYPRPPSK;VYPRPPSKTYRGAFQNLFQSVR 4 6.5 0.76818 0.056958 0 0 0 0 0 0 0 7.36711 0 0 0 0 P10275 ANDR_HUMAN Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR DHTR NR3C4 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular receptor signaling pathway [GO:0030522]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" KCYEAGMTLGAAVVVSERILR;RAAEGKQK;VYPRPPSK;VYPRPPSKTYRGAFQNLFQSVR 4 7.9 0.76505 0.066865 0 0 0 0 0 0 0 8.75726 0 0 0 0 P10276 RARA_HUMAN Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) RARA NR1B1 Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; chondroblast differentiation [GO:0060591]; embryonic camera-type eye development [GO:0031076]; face development [GO:0060324]; female pregnancy [GO:0007565]; germ cell development [GO:0007281]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hippocampus development [GO:0021766]; limb development [GO:0060173]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; neural tube closure [GO:0001843]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of binding [GO:0051099]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of myelination [GO:0031641]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid receptor signaling pathway [GO:0048384]; Sertoli cell fate commitment [GO:0060010]; spermatogenesis [GO:0007283]; trachea cartilage development [GO:0060534]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "alpha-actinin binding [GO:0051393]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; histone deacetylase binding [GO:0042826]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase B binding [GO:0043422]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" FSELSTK;FSELSTKCIIK 2 2.4 0.95277 -0.73454 10.9085 7.27072 0 0 0 0 0 9.77872 3.94345 0 0 0 P10301 RRAS_HUMAN Ras-related protein R-Ras (EC 3.6.5.-) (p23) RRAS Homo sapiens (Human) face morphogenesis [GO:0060325]; leukocyte differentiation [GO:0002521]; negative regulation of Schwann cell migration [GO:1900148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; Schwann cell migration [GO:0036135] extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877] SSGAASGTGR 1 4.6 0.93492 -0.53032 0 0 0 0 0 0 0 0 0 0 9.29634 0 P10323 ACRO_HUMAN Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] ACR ACRS Homo sapiens (Human) acrosome matrix dispersal [GO:0002077]; acrosome reaction [GO:0007340]; activation of adenylate cyclase activity [GO:0007190]; binding of sperm to zona pellucida [GO:0007339]; penetration of zona pellucida [GO:0007341]; response to steroid hormone [GO:0048545]; single fertilization [GO:0007338] acrosomal matrix [GO:0043159]; extracellular region [GO:0005576]; Golgi-associated vesicle [GO:0005798]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] amidase activity [GO:0004040]; copper ion binding [GO:0005507]; D-mannose binding [GO:0005537]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; zinc ion binding [GO:0008270] VEMLPTAILLVLAVSVVAK 1 4.5 0.64091 0.17203 5.85709 0 0 0 0 0 0 0 0 0 0 0 P10412 H14_HUMAN Histone H1.4 (Histone H1b) (Histone H1s-4) H1-4 H1F4 HIST1H1E Homo sapiens (Human) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] AAKPKTAKPK;ALAAAGYDVEK;ALAAAGYDVEKNNSR;ASGPPVSELITK;GTGASGSFK;GTLVQTK;KASGPPVSELITK;KPAGAAK;KSAGAAK;LGLKSLVSKGTLVQTK;SETAPAAPAAPAPAEK;SGVSLAALK;SGVSLAALKK 13 47 0 2.8411 0 12.7844 0 0 0 0 0 8.97131 9.05458 9.18775 8.20979 8.09191 P10515 ODP2_HUMAN "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)" DLAT DLTA Homo sapiens (Human) acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; identical protein binding [GO:0042802] ALCGWTPSSGATPR;KEGDKINEGDLIAEVETDK;LAVEKGIDLTQVK 3 7.1 0.91077 -0.32585 0 0 0 0 0 0 0 10.7598 0 6.65105 0 10.8619 P10586 PTPRF_HUMAN Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) PTPRF LAR Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; negative regulation of receptor binding [GO:1900121]; nervous system development [GO:0007399]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] "cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DEQSIGLKDSLLAHSSDPVEMR;FEVIEFDDGAGSVLR;LNYQTPGMR;NRAGLGEEFEKEIR;TIRQFQFTDWPEQGVPK 5 4 0.97857 -2.1153 0 0 0 0 8.40595 10.6066 0 0 8.5575 0 0 0 P10588 NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) NR2F6 EAR2 ERBAL2 Homo sapiens (Human) cell differentiation [GO:0030154]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" CFRVGMR;LLFSTVEWAR;MAMVTGGWGGPGGDTNGVDKAGGYPR 3 10.6 0.95888 -1.0346 0 0 0 9.68082 0 0 10.6918 0 0 0 0 0 P10589 COT1_HUMAN COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) NR2F1 EAR3 ERBAL3 TFCOUP1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" HYGQFTCEGCKSFFK;NLTYTCR 2 5.2 0.90956 -0.31228 9.64243 0 4.65226 0 0 0 0 0 0 0 0 0 P10599 THIO_HUMAN Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) TXN TRDX TRX TRX1 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular detoxification of hydrogen peroxide [GO:0061692]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to nitric oxide [GO:0071731]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803]; protein-disulfide reductase (NAD(P)H) activity [GO:0047134]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] EKLEATINELV;LEATINELV;TAFQEALDAAGDK;VGEFSGANK;VGEFSGANKEK 5 31.4 0 8.289 0 0 10.4756 0 9.92636 0 0 0 13.1215 13.3142 11.6131 0 P10600 TGFB3_HUMAN Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)] TGFB3 Homo sapiens (Human) cell-cell junction organization [GO:0045216]; detection of hypoxia [GO:0070483]; digestive tract development [GO:0048565]; embryonic neurocranium morphogenesis [GO:0048702]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; lung alveolus development [GO:0048286]; mammary gland development [GO:0030879]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; T-tubule [GO:0030315] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; transforming growth factor beta binding [GO:0050431]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] QDLGWKWVHEPK;VPNPSSK 2 4.6 0.90244 -0.26352 0 0 0 12.8173 7.8051 0 0 0 11.8837 14.4376 8.69077 0 P10606 COX5B_HUMAN "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)" COX5B Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory gaseous exchange by respiratory system [GO:0007585]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129]; metal ion binding [GO:0046872] EDPNLVPSISNKR 1 10.1 0.30317 0.24977 0 0 11.6947 0 0 0 0 0 0 0 0 0 P10619 PPGB_HUMAN Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] CTSA PPGB Homo sapiens (Human) intracellular protein transport [GO:0006886]; negative regulation of chaperone-mediated autophagy [GO:1904715]; proteolysis [GO:0006508]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of protein stability [GO:0031647] azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] carboxypeptidase activity [GO:0004180]; enzyme activator activity [GO:0008047]; serine-type carboxypeptidase activity [GO:0004185] ALNIPEQLPQWDMCNFLVNLQYRRLYR;FLNKQPY 2 7.1 0.96392 -1.1806 0 0 0 0 0 0 0 7.70543 0 0 0 0 P10620 MGST1_HUMAN Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) MGST1 GST12 MGST Homo sapiens (Human) cellular response to lipid hydroperoxide [GO:0071449]; glutathione transport [GO:0034635] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364] IYHTIAYLTPLPQPNR 1 10.3 0.68464 0.16289 0 0 0 0 0 0 0 0 11.1586 0 0 0 P10632 CP2C8_HUMAN Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "arachidonate epoxygenase activity [GO:0008392]; caffeine oxidase activity [GO:0034875]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]" GLGIISSNGKRWK;SEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLK 2 10 0.86483 -0.085716 0 0 0 0 0 0 10.2029 7.28253 0 0 0 0 P10635 CP2D6_HUMAN Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) CYP2D6 CYP2DL1 Homo sapiens (Human) alkaloid catabolic process [GO:0009822]; alkaloid metabolic process [GO:0009820]; arachidonate metabolic process [GO:0019369]; cholesterol metabolic process [GO:0008203]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; isoquinoline alkaloid metabolic process [GO:0033076]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; negative regulation of binding [GO:0051100]; negative regulation of organofluorine metabolic process [GO:0090350]; oxidative demethylation [GO:0070989]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] "anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" AFLTQLDELLTEHR;EESGFLR;LLDLAQEGLKEESGFLR 3 6.2 0.91642 -0.42265 11.0238 0 10.1628 0 0 0 0 10.341 0 8.23103 0 0 P10636 TAU_HUMAN Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) MAPT MAPTL MTBT1 TAU Homo sapiens (Human) amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; axon development [GO:0061564]; axonal transport [GO:0098930]; axonal transport of mitochondrion [GO:0019896]; cell-cell signaling [GO:0007267]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to reactive oxygen species [GO:0034614]; central nervous system neuron development [GO:0021954]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; generation of neurons [GO:0048699]; intracellular distribution of mitochondria [GO:0048312]; learning or memory [GO:0007611]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of tubulin deacetylation [GO:1904428]; neurofibrillary tangle assembly [GO:1902988]; neuron projection development [GO:0031175]; plus-end-directed organelle transport along microtubule [GO:0072386]; positive regulation of axon extension [GO:0045773]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of superoxide anion generation [GO:0032930]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular response to heat [GO:1900034]; regulation of chromosome organization [GO:0033044]; regulation of long-term synaptic depression [GO:1900452]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of mitochondrial fission [GO:0090140]; regulation of synaptic plasticity [GO:0048167]; response to lead ion [GO:0010288]; rRNA metabolic process [GO:0016072]; stress granule assembly [GO:0034063]; supramolecular fiber organization [GO:0097435]; synapse assembly [GO:0007416]; synapse organization [GO:0050808] axolemma [GO:0030673]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; main axon [GO:0044304]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; somatodendritic compartment [GO:0036477]; tubulin complex [GO:0045298] actin binding [GO:0003779]; apolipoprotein binding [GO:0034185]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; dynactin binding [GO:0034452]; enzyme binding [GO:0019899]; histone-dependent DNA binding [GO:0099077]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; microtubule binding [GO:0008017]; microtubule lateral binding [GO:0099609]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol bisphosphate binding [GO:1902936]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; SH3 domain binding [GO:0017124]; single-stranded DNA binding [GO:0003697] DGTGSDDKKAK;HQPGGGK;IGSTENLK;SPVVSGDTSPR;VQIINKKLDLSNVQSK 5 12 0.98021 -1.8074 9.82675 0 12.3574 0 0 7.0863 8.86323 0 0 0 0 0 P10643 CO7_HUMAN Complement component C7 C7 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] GCPTEEGCGER;ILPLTVCK;LTPLYELVK 3 3.3 0.97626 -1.4755 0 0 0 0 0 0 0 0 11.5387 0 0 5.74588 P10644 KAP0_HUMAN cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) PRKAR1A PKR1 PRKAR1 TSE1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cardiac muscle cell proliferation [GO:0060038]; cellular response to glucagon stimulus [GO:0071377]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cAMP/PKA signal transduction [GO:0141162]; negative regulation of gene expression [GO:0010629]; positive regulation of insulin secretion [GO:0032024]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214] cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; sperm head-tail coupling apparatus [GO:0120212] cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625] MESGSTAASEEAR;QIQNLQKAGTR;QIQNLQKAGTRTDSR;SLRECELYVQK 4 10.2 0.88337 -0.17252 0 0 0 0 6.3378 0 0 0 0 8.71249 8.55209 8.62392 P10645 CMGA_HUMAN Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] CHGA Homo sapiens (Human) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [GO:0086030]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; mast cell activation [GO:0045576]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of relaxation of cardiac muscle [GO:1901899]; protein localization to secretory granule [GO:0033366]; regulation of blood pressure [GO:0008217]; regulation of the force of heart contraction [GO:0002026] chromaffin granule [GO:0042583]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] LEGQEEEEDNRDSSMK 1 3.5 0.91579 -0.43413 0 0 0 0 0 0 0 0 0 6.68524 0 0 P10720 PF4V_HUMAN Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)] PF4V1 CXCL4V1 SCYB4V1 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593] extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201] LTRATRQEMLFLALLLLPVVVAFAR 1 24 0.66235 0.16893 0 5.73577 0 0 0 0 0 0 0 0 0 0 P10721 KIT_HUMAN Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) KIT SCFR Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; B cell differentiation [GO:0030183]; cell chemotaxis [GO:0060326]; cytokine-mediated signaling pathway [GO:0019221]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation [GO:0050673]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; germ cell migration [GO:0008354]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; hemopoiesis [GO:0030097]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of developmental process [GO:0051093]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reproductive process [GO:2000242]; ovarian follicle development [GO:0001541]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of colon smooth muscle contraction [GO:1904343]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of pyloric antrum smooth muscle contraction [GO:0120072]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein autophosphorylation [GO:0046777]; regulation of bile acid metabolic process [GO:1904251]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; response to cadmium ion [GO:0046686]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; T cell differentiation [GO:0030217]; tongue development [GO:0043586]; visual learning [GO:0008542] acrosomal vesicle [GO:0001669]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine binding [GO:0019955]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LLCTDPGFVK 1 1 0.92194 -0.44531 0 0 0 0 0 10.0602 0 0 0 0 0 0 P10747 CD28_HUMAN T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) CD28 Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative thymic T cell selection [GO:0045060]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; regulation of regulatory T cell differentiation [GO:0045589]; regulatory T cell differentiation [GO:0045066]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transcription by RNA polymerase II [GO:0006366]" cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636] coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] IEVMYPPPYLDNEK;LRLLLALNLFPSIQVTGNKILVK 2 16.8 0.86574 -0.091958 0 0 0 5.75106 0 0 0 0 0 0 0 0 P10747 CD28_HUMAN T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) CD28 Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative thymic T cell selection [GO:0045060]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; regulation of regulatory T cell differentiation [GO:0045589]; regulatory T cell differentiation [GO:0045066]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transcription by RNA polymerase II [GO:0006366]" cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636] coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] GMVAVVVAVDDGDSQALAGNK;IEVMYPPPYLDNEK 2 15 0.91774 -0.40874 0 0 0 0 0 0 10.7259 0 0 0 0 10.4594 P10767 FGF6_HUMAN Fibroblast growth factor 6 (FGF-6) (Heparin secretory-transforming protein 2) (HST-2) (HSTF-2) (Heparin-binding growth factor 6) (HBGF-6) FGF6 HST2 HSTF2 Homo sapiens (Human) angiogenesis [GO:0001525]; cartilage condensation [GO:0001502]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast differentiation [GO:0045445]; neurogenesis [GO:0022008]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcolemma [GO:0042383] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] GRLYATPSFQEECK;LYATPSFQEECK 2 6.7 0.91597 -0.43136 0 0 0 0 6.69056 6.27353 4.41569 0 0 0 0 5.91767 P10809 CH60_HUMAN "60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)" HSPD1 HSP60 Homo sapiens (Human) 'de novo' protein folding [GO:0006458]; apoptotic mitochondrial changes [GO:0008637]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to interleukin-7 [GO:0098761]; chaperone-mediated protein complex assembly [GO:0051131]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation [GO:0051604]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to cold [GO:0009409]; response to unfolded protein [GO:0006986]; T cell activation [GO:0042110] cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; membrane [GO:0016020]; migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524] apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; high-density lipoprotein particle binding [GO:0008035]; isomerase activity [GO:0016853]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] AAVEEGIVLGGGCALLR;ALMLQGVDLLADAVAVTMGPK;APGFGDNR;APGFGDNRK;GANPVEIR;GIIDPTK;GYISPYFINTSK;IMQSSSEVGYDAMAGDFVNMVEK;IPAMTIAK;ISKGANPVEIR;ISSIQSIVPALEIANAHR;KPLVIIAEDVDGEALSTLVLNR;LSDGVAVLK;LVQDVANNTNEEAGDGTTTATVLAR;NAGVEGSLIVEK;TLKIPAMTIAK;TLNDELEIIEGMK;TVIIEQSWGSPK;VGEVIVTK;VGEVIVTKDDAMLLK;VGGTSDVEVNEK;VGGTSDVEVNEKK;VGLQVVAVK;VTDALNATR 24 46.8 0 225.31 16.5326 16.8848 16.4085 13.311 13.9502 12.8199 15.1217 15.1971 15.2968 15.6491 15.6332 14.1835 P10826 RARB_HUMAN Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) RARB HAP NR1B2 Homo sapiens (Human) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myelination [GO:0031641]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; striatum development [GO:0021756]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; heterocyclic compound binding [GO:1901363]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LQEPLLEALKIYIRK 1 3.3 0.96535 -1.1582 0 0 0 0 0 9.21907 0 0 0 0 0 0 P10827 THA_HUMAN Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) THRA EAR7 ERBA1 NR1A1 THRA1 THRA2 Homo sapiens (Human) cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; erythrocyte differentiation [GO:0030218]; female courtship behavior [GO:0008050]; hormone-mediated signaling pathway [GO:0009755]; learning or memory [GO:0007611]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of DNA-templated transcription initiation [GO:2000143]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of female receptivity [GO:0045925]; positive regulation of thyroid hormone receptor signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of lipid catabolic process [GO:0050994]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of thyroid hormone receptor signaling pathway [GO:0002155]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; retinoic acid receptor signaling pathway [GO:0048384]; thyroid gland development [GO:0030878]; thyroid hormone receptor signaling pathway [GO:0002154]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; TBP-class protein binding [GO:0017025]; thyroid hormone binding [GO:0070324]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" TIQKNLHPTYSCK 1 2.7 0.94671 -0.65682 0 0 0 9.64348 0 0 0 0 0 0 0 0 P10828 THB_HUMAN Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta) THRB ERBA2 NR1A2 THR1 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to thyroid hormone stimulus [GO:0097067]; DNA-templated transcription [GO:0006351]; female courtship behavior [GO:0008050]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of female receptivity [GO:0007621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of thyroid hormone receptor signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; retinoic acid receptor signaling pathway [GO:0048384]; sensory perception of sound [GO:0007605]; thyroid hormone receptor signaling pathway [GO:0002154]; type I pneumocyte differentiation [GO:0060509] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; thyroid hormone binding [GO:0070324]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" GYIPSYLDK;NQCQECRFK 2 3.9 0.93732 -0.57626 0 0 0 0 9.50082 0 0 0 0 0 7.69884 0 P10909 CLUS_HUMAN "Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]" CLU APOJ CLI KUB1 AAG4 Homo sapiens (Human) "amyloid-beta clearance [GO:0097242]; cell morphogenesis [GO:0000902]; central nervous system myelin maintenance [GO:0032286]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; immune complex clearance [GO:0002434]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neurofibrillary tangle assembly [GO:1902998]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of neuronal signal transduction [GO:1902847]; release of cytochrome c from mitochondria [GO:0001836]; response to misfolded protein [GO:0051788]; response to virus [GO:0009615]; reverse cholesterol transport [GO:0043691]" apical dendrite [GO:0097440]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum lumen [GO:0099020]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; spherical high-density lipoprotein particle [GO:0034366]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; misfolded protein binding [GO:0051787]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] EIRHNSTGCLRMK;KTLLSNLEEAKK;YNELLKSYQWK 3 8 0.95517 -0.88321 0 8.16068 7.12174 2.45349 0 9.42436 0 5.05702 6.99005 0 0 0 P10911 MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein] MCF2 DBL Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; dendrite development [GO:0016358]; intracellular signal transduction [GO:0035556]; negative regulation of axonogenesis [GO:0050771]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] DDFQMYAK;FQISLQQNDEK;MIMQGGFSVWIGHK;MQDIAFLSGGR;QNQSNLK;QNQSNLKIEVVPDCQEK;RKQQDQLTER;VGPCFLERK 8 8.1 0.97462 -2.3916 0 0 0 7.03683 0 12.4258 0 0 0 6.56593 13.0901 13.4358 P10912 GHR_HUMAN Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] GHR Homo sapiens (Human) cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; endocytosis [GO:0006897]; growth hormone receptor signaling pathway [GO:0060396]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; receptor internalization [GO:0031623]; regulation of multicellular organism growth [GO:0040014]; regulation of response to nutrient levels [GO:0032107]; response to cycloheximide [GO:0046898]; response to estradiol [GO:0032355]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to interleukin-1 [GO:0070555]; taurine metabolic process [GO:0019530] cell surface [GO:0009986]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; growth hormone receptor activity [GO:0004903]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptide hormone binding [GO:0017046]; proline-rich region binding [GO:0070064]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169] LTSNGGTVDEK;MLILPPVPVPK 2 3.4 0.95218 -0.72054 0 0 0 0 0 0 0 0 8.91609 0 0 0 P10915 HPLN1_HUMAN Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) HAPLN1 CRTL1 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540] EPCGGQNTVPGVRNYGFWDKDK;TYGGYQGRVFLK 2 9.6 0.96492 -1.1638 0 0 0 0 0 0 12.6437 0 0 0 11.9893 0 P10916 MLRV_HUMAN "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)" MYL2 MLC2 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cardiac myofibril assembly [GO:0055003]; heart contraction [GO:0060047]; heart development [GO:0007507]; muscle cell fate specification [GO:0042694]; negative regulation of cell growth [GO:0030308]; positive regulation of the force of heart contraction [GO:0098735]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] A band [GO:0031672]; cardiac myofibril [GO:0097512]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; myosin complex [GO:0016459]; sarcomere [GO:0030017] actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307] VNVKNEEIDEMIK 1 7.8 0.95235 -0.68314 0 0 0 0 0 9.79823 0 0 10.5872 0 0 0 P10966 CD8B_HUMAN T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) CD8B CD8B1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] cell surface [GO:0009986]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101] coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288] QLRLHPLEKCSR 1 5.4 0.61003 0.1754 0 0 0 0 0 0 0 0 0 0 6.31765 0 P10966 CD8B_HUMAN T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) CD8B CD8B1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; immune response [GO:0006955]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] cell surface [GO:0009986]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; T cell receptor complex [GO:0042101] coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288] IGFWCPATK 1 4.4 0.84624 -0.065072 5.91762 0 0 0 0 0 0 0 0 0 0 0 P10997 IAPP_HUMAN Islet amyloid polypeptide (IAPP) (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide) IAPP Homo sapiens (Human) amylin receptor 1 signaling pathway [GO:0150059]; amylin receptor 2 signaling pathway [GO:0150060]; amylin receptor 3 signaling pathway [GO:0150061]; amylin receptor signaling pathway [GO:0097647]; apoptotic process [GO:0006915]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein-containing complex assembly [GO:0031333]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of MAPK cascade [GO:0043410]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025] amyloid-beta binding [GO:0001540]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] MGILKLQVFLIVLSVALNHLK;RNAVEVLKR 2 33.7 0.96161 -1.0667 0 0 0 12.0281 9.30072 0 0 10.3336 0 0 0 0 P11021 BIP_HUMAN Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) HSPA5 GRP78 Homo sapiens (Human) "cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein folding in endoplasmic reticulum [GO:0034975]; protein refolding [GO:0042026]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-folding chaperone binding [GO:0051087]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] ALSSQHQAR;DAGTIAGLNVMR;DNHLLGTFDLTGIPPAPR;ELEEIVQPIISK;ETAEAYLGK;FAEEDKK;IDTRNELESYAYSLK;IINEPTAAAIAYGLDK;IINEPTAAAIAYGLDKR;ITITNDQNR;ITPSYVAFTPEGER;ITPSYVAFTPEGERLIGDAAK;LYGSAGPPPTGEEDTAEKDEL;MVNDAEK;NQLTSNPENTVFDAK;NQLTSNPENTVFDAKR;NTVVPTK;NTVVPTKK;SDIDEIVLVGGSTR;SQIFSTASDNQPTVTIK;TFAPEEISAMVLTK;TWNDPSVQQDIK;TWNDPSVQQDIKFLPFK;VLEDSDLKK;VMEHFIK;VTHAVVTVPAYFNDAQR;VYEGERPLTK 27 43.7 0 178.05 14.9713 15.2945 15.0982 13.2833 13.3871 12.6305 15.0618 15.5031 15.8766 15.4991 14.8963 15.5101 P11047 LAMC1_HUMAN Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) LAMC1 LAMB2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; endoderm development [GO:0007492]; extracellular matrix disassembly [GO:0022617]; hemidesmosome assembly [GO:0031581]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of cell adhesion [GO:0045785]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein-containing complex assembly [GO:0065003]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201] ANRGFIR;LIEIASR;LLNNLTSIKIR;RCELCDDGYFGDPLGR;VLKSYYYAISDFAVGGR;VLKSYYYAISDFAVGGRCK 6 3.7 0.97494 -3.8846 0 0 0 8.37717 10.0579 0 0 9.26271 12.2793 0 0 0 P11055 MYH3_HUMAN "Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)" MYH3 Homo sapiens (Human) actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; muscle organ development [GO:0007517]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018] IAEKDEEIEQLK;LAQESILDLENDKQQLDER;LQTEAGELSR;LYDQHLGK;TKDELAKSEAK;TLVVKPEDVYAMNPPKFDR 6 4.1 0.95526 -0.79091 0 0 0 9.64591 0 0 11.2939 0 0 0 8.1103 0 P11086 PNMT_HUMAN Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) PNMT PENT Homo sapiens (Human) catecholamine biosynthetic process [GO:0042423]; epinephrine biosynthetic process [GO:0042418]; methylation [GO:0032259] cytosol [GO:0005829] phenylethanolamine N-methyltransferase activity [GO:0004603] ALDHITTLLRPGGHLLLIGALEESWYLAGEAR;GVFFAWAQK 2 14.5 0.91742 -0.35774 0 0 0 0 0 8.61427 0 0 12.2434 0 0 0 P11137 MTAP2_HUMAN Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) central nervous system neuron development [GO:0021954]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of axon extension [GO:0030517]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle transport along microtubule [GO:1902513]; regulation of protein localization [GO:0032880] apical distal dendrite [GO:0150014]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic branch [GO:0044307]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; dendritic shaft [GO:0043198]; distal dendrite [GO:0150002]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; proximal dendrite [GO:1990635]; proximal neuron projection [GO:1990769] calmodulin binding [GO:0005516]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156] EFDQEKKANDR;GLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVK;IDSQKLNFREHAK;IEEPHEAKPDK;IGSTDNIKYQPK;KDMQGTEEEK;KTEVQAHSPSR;LAAAGRVK;LASVSADAEVARR;LEEKTTISDK;QLRLINQPLPDLKNVK;TLEKAMTEPSALIEK;TPGTPGTPSYPRTPHTPGTPK;VGSLDNAHHVPGGGNVK;VSDGVTK 15 11.3 0.97831 -6.5928 0 12.373 12.3089 0 11.44 9.10093 12.153 12.7895 10.9285 0 6.07067 6.77452 P11137 MTAP2_HUMAN Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) central nervous system neuron development [GO:0021954]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of axon extension [GO:0030517]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle transport along microtubule [GO:1902513]; regulation of protein localization [GO:0032880] apical distal dendrite [GO:0150014]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic branch [GO:0044307]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; dendritic shaft [GO:0043198]; distal dendrite [GO:0150002]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; proximal dendrite [GO:1990635]; proximal neuron projection [GO:1990769] calmodulin binding [GO:0005516]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156] IDFSKVQSRCGSK;IDSQKLNFREHAK;IGSTDNIKYQPK;QLRLINQPLPDLKNVK;TPGTPGTPSYPRTPHTPGTPK;VGSLDNAHHVPGGGNVK 6 16.5 0.86471 -0.087619 0 0 0 0 0 0 0 0 0 0 6.46927 0 P11142 HSP7C_HUMAN Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) HSPA8 HSC70 HSP73 HSPA10 Homo sapiens (Human) "ATP metabolic process [GO:0046034]; cellular response to starvation [GO:0009267]; cellular response to steroid hormone stimulus [GO:0071383]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; clathrin coat disassembly [GO:0072318]; membrane organization [GO:0061024]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of supramolecular fiber organization [GO:1902904]; positive regulation of cell migration [GO:0030335]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of protein complex stability [GO:0061635]; regulation of protein import [GO:1904589]; regulation of protein stability [GO:0031647]; regulation of protein-containing complex assembly [GO:0043254]; response to unfolded protein [GO:0006986]" blood microparticle [GO:0072562]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lumenal side of lysosomal membrane [GO:0098575]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; Prp19 complex [GO:0000974]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; MHC class II protein complex binding [GO:0023026]; protein carrier chaperone [GO:0140597]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] ARFEELNADLFR;ATVEDEK;DAGTIAGLNVLR;DNNLLGK;EEFEHQQK;EIAEAYLGK;GTLDPVEK;IINEPTAAAIAYGLDK;IINEPTAAAIAYGLDKK;ITITNDK;ITITNDKGR;LLQDFFNGK;LLQDFFNGKELNK;LSKEDIER;MKEIAEAYLGK;MVQEAEK;NQVAMNPTNTVFDAK;NQVAMNPTNTVFDAKR;NSLESYAFNMK;NTTIPTK;QTQTFTTYSDNQPGVLIQVYEGER;SFYPEEVSSMVLTK;SINPDEAVAYGAAVQAAILSGDK;SQIHDIVLVGGSTR;SQIHDIVLVGGSTRIPKIQK;STAGDTHLGGEDFDNR;TACERAK;TTPSYVAFTDTER;TTPSYVAFTDTERLIGDAAK;TVTNAVVTVPAYFNDSQR;VQVEYKGETK 31 47.2 0 245.06 17.0846 16.8248 16.3734 13.4981 13.7478 12.7653 15.7954 16.0006 15.7102 14.1531 13.7555 15.4147 P11166 GTR1_HUMAN "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)" SLC2A1 GLUT1 Homo sapiens (Human) cellular hyperosmotic response [GO:0071474]; cellular response to glucose starvation [GO:0042149]; cellular response to mechanical stimulus [GO:0071260]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; D-glucose import [GO:0046323]; D-glucose import across plasma membrane [GO:0098708]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; female pregnancy [GO:0007565]; L-ascorbic acid metabolic process [GO:0019852]; long-chain fatty acid import across plasma membrane [GO:0015911]; photoreceptor cell maintenance [GO:0045494]; protein-containing complex assembly [GO:0065003]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to Thyroglobulin triiodothyronine [GO:1904016]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; glucose transporter complex [GO:1990350]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; Z disc [GO:0030018] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; xenobiotic transmembrane transporter activity [GO:0042910] QGGASQSDKTPEELFHPLGADSQV;TFDEIASGFR;VTILELFR 3 8.5 0 5.9476 0 12.7398 13.0249 0 0 0 0 0 0 0 0 0 P11171 EPB41_HUMAN Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) EPB41 E41P Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to cell cortex [GO:1904778]; protein-containing complex assembly [GO:0065003]; regulation of calcium ion transport [GO:0051924]; regulation of intestinal absorption [GO:1904478] basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spectrin-associated cytoskeleton [GO:0014731] 1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; phosphoprotein binding [GO:0051219]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] EEGEEAINSGQQEPQQEESCQTAAEGDNWCEQK;EVESDKEKGEGGQK;LDGENIYIR;THIEVTVPTSNGDQTQK;TVVPKAQK 5 9.4 0.98082 -1.7395 11.7711 0 17.3375 11.5951 15.5148 11.2281 10.9642 0 0 17.4379 0 0 P11172 UMPS_HUMAN Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] UMPS OK/SW-cl.21 Homo sapiens (Human) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; lactation [GO:0007595]; pyrimidine nucleobase biosynthetic process [GO:0019856]; UDP biosynthetic process [GO:0006225]; UMP biosynthetic process [GO:0006222] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] LEILEQQK 1 3.9 0.93726 -0.55357 0 0 0 0 0 8.83848 0 0 0 0 0 0 P11182 ODB2_HUMAN "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)" DBT BCATE2 BCKDHE2 Homo sapiens (Human) branched-chain amino acid catabolic process [GO:0009083] branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] "acetyltransferase activity [GO:0016407]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity [GO:0043754]; lipoic acid binding [GO:0031405]; ubiquitin protein ligase binding [GO:0031625]" LSFMPFFLK 1 1.9 0.871 -0.10165 12.0613 0 0 0 0 8.65575 0 13.3195 13.5137 0 0 0 P11215 ITAM_HUMAN Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) ITGAM CD11B CR3A Homo sapiens (Human) "amyloid-beta clearance [GO:0097242]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-matrix adhesion [GO:0007160]; complement receptor mediated signaling pathway [GO:0002430]; complement-mediated synapse pruning [GO:0150062]; ectodermal cell differentiation [GO:0010668]; forebrain development [GO:0030900]; heterotypic cell-cell adhesion [GO:0034113]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; phagocytosis, engulfment [GO:0006911]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]; response to curcumin [GO:1904643]; response to estradiol [GO:0032355]; response to Gram-positive bacterium [GO:0140459]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; vertebrate eye-specific patterning [GO:0150064]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integrin alphaM-beta2 complex [GO:0034688]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] EAGEVRVCLHVQK 1 1.1 0.95284 -0.68206 0 0 0 0 0 0 0 0 0 0 0 10.8691 P11216 PYGB_HUMAN "Glycogen phosphorylase, brain form (EC 2.4.1.1)" PYGB Homo sapiens (Human) glycogen catabolic process [GO:0005980] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] glycogen phosphorylase activity [GO:0008184]; maltodextrin phosphorylase activity [GO:0031220]; pyridoxal phosphate binding [GO:0030170] FSAFLEKEYK;ILVDVEKVDWDK;INPSSMFDVHVKR;LKQEYFVVAATLQDIIRR;LLPLVSDEVFIRDVAK;LLPRHLEIIYAINQR;TNGITPR;TVMIGGK;TVMIGGKAAPGYHMAK;VIFLENYR 10 13.6 0.9741 -3.7969 10.8497 0 9.78152 9.16355 10.6711 10.5825 0 11.0532 10.4636 0 0 0 P11229 ACM1_HUMAN Muscarinic acetylcholine receptor M1 CHRM1 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of monoatomic ion transport [GO:0043270]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of glial cell proliferation [GO:0060251]; regulation of locomotion [GO:0040012]; regulation of postsynaptic membrane potential [GO:0060078]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]" axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202] G protein-coupled acetylcholine receptor activity [GO:0016907]; phosphatidylinositol phospholipase C activity [GO:0004435] ETENRAR;ETENRARELAALQGSETPGK;MPMVDPEAQAPTKQPPR 3 8 0.9803 -1.8146 0 0 0 0 6.61361 0 0 0 0 7.08012 0 0 P11230 ACHB_HUMAN Acetylcholine receptor subunit beta CHRNB1 ACHRB CHRNB Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; membrane depolarization [GO:0051899]; monoatomic cation transport [GO:0006812]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; ligand-gated monoatomic ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] KPPSDFLFPKPNR 1 2.6 0.8764 -0.12554 0 0 0 0 0 9.08412 0 0 0 0 0 0 P11233 RALA_HUMAN Ras-related protein Ral-A (EC 3.6.5.2) RALA RAL Homo sapiens (Human) cell division [GO:0051301]; chemotaxis [GO:0006935]; establishment of protein localization to mitochondrion [GO:0072655]; exocytosis [GO:0006887]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of mitochondrial fission [GO:0090141]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of exocytosis [GO:0017157]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060] ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625] AANKPKGQNSLALHKVIMVGSGGVGK;VIMVGSGGVGK 2 12.6 0.68348 0.16504 0 0 0 0 0 0 0 8.70338 0 0 0 0 P11234 RALB_HUMAN Ras-related protein Ral-B (EC 3.6.5.2) RALB Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; midbody [GO:0030496]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625] QSALQWVICVSQPQK;QVPVEEAR;VIMVGSGGVGK 3 14.9 0.89262 -0.2233 0 0 8.4245 0 0 0 0 0 9.67016 0 0 0 P11234 RALB_HUMAN Ras-related protein Ral-B (EC 3.6.5.2) RALB Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; midbody [GO:0030496]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625] KVEGILEFVEDYEPTK;MAANKSK;QVPVEEAR;VIMVGSGGVGK 4 18.5 0.97816 -1.944 0 11.1952 7.7322 0 0 0 0 0 0 9.723 0 10.5497 P11245 ARY2_HUMAN Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (N-hydroxyarylamine O-acetyltransferase) (EC 2.3.1.118) (Polymorphic arylamine N-acetyltransferase) (PNAT) NAT2 AAC2 Homo sapiens (Human) xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829] arylamine N-acetyltransferase activity [GO:0004060]; N-hydroxyarylamine O-acetyltransferase activity [GO:0046990] EFLNSHLLPK 1 3.4 0.93422 -0.50426 0 0 0 0 0 0 0 0 0 8.1533 0 0 P11274 BCR_HUMAN Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) BCR BCR1 D22S11 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; cellular response to lipopolysaccharide [GO:0071222]; definitive hemopoiesis [GO:0060216]; focal adhesion assembly [GO:0048041]; homeostasis of number of cells [GO:0048872]; inner ear morphogenesis [GO:0042472]; intracellular protein transmembrane transport [GO:0065002]; keratinocyte differentiation [GO:0030216]; macrophage migration [GO:1905517]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of respiratory burst [GO:0060268]; neuromuscular process controlling balance [GO:0050885]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of vascular permeability [GO:0043114]; renal system process [GO:0003014]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ISQIKNDIQREK;ISQNFLSSINEEITPR;NGKSYTFLISSDYERAEWR;SPSQNSQQSFDSSSPPTPQCHK;VPELYEIHK 5 6.1 0.95545 -0.98028 0 9.42964 0 8.92062 8.24294 8.19505 4.50341 0 0 0 6.23268 11.9627 P11277 SPTB1_HUMAN "Spectrin beta chain, erythrocytic (Beta-I spectrin)" SPTB SPTB1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; modification of postsynaptic actin cytoskeleton [GO:0098885] actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell surface [GO:0009986]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; structural constituent of cytoskeleton [GO:0005200] AHLLSAEFGKHLLEVEDLLQK;DALLLWCQMK;DLAGIIAIQR;EKLQQVMSRR;ELALRNELIR;LLTSQDVSYDEAR;LSGLERDVAAIQAR;LVAEGNLYSDK;QRLETTLALQKLFQDMLHSIDWMDEIK;RQRLETTLALQK;SHTLAQCLGFQEFQK;VEDQVNVRK;VHNYCVDCEETSK 13 7.7 0.98062 -1.6203 0 6.84937 0 9.87075 5.45118 11.2651 0 5.80147 0 6.97579 10.7811 10.7773 P11279 LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) LAMP1 Homo sapiens (Human) establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; lysosomal lumen acidification [GO:0007042]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513] autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagolysosome membrane [GO:0061474]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein domain specific binding [GO:0019904]; virus receptor activity [GO:0001618] AFSVNIFKVWVQAFK;ALQATVGNSYK 2 6.2 0 2.0788 0 0 0 10.1797 0 0 0 0 0 0 0 0 P11308 ERG_HUMAN Transcriptional regulator ERG (Transforming protein ERG) ERG Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ELCKMTK;NIMTKVHGK 2 3.3 0.97919 -1.8807 0 0 0 0 8.49041 0 0 0 9.51231 0 0 0 P11310 ACADM_HUMAN "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH)" ACADM Homo sapiens (Human) "cardiac muscle cell differentiation [GO:0055007]; carnitine biosynthetic process [GO:0045329]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; glycogen biosynthetic process [GO:0005978]; liver development [GO:0001889]; medium-chain fatty acid catabolic process [GO:0051793]; medium-chain fatty acid metabolic process [GO:0051791]; post-embryonic development [GO:0009791]; regulation of gluconeogenesis [GO:0006111]; response to cold [GO:0009409]; response to starvation [GO:0042594]" axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991] MWITNGGKANWYFLLAR;VLRSISRFHWR 2 6.7 0.93569 -0.5205 0 0 9.81003 0 0 0 0 8.16852 9.22971 11.367 11.1689 0 P11310 ACADM_HUMAN "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH)" ACADM Homo sapiens (Human) "cardiac muscle cell differentiation [GO:0055007]; carnitine biosynthetic process [GO:0045329]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; glycogen biosynthetic process [GO:0005978]; liver development [GO:0001889]; medium-chain fatty acid catabolic process [GO:0051793]; medium-chain fatty acid metabolic process [GO:0051791]; post-embryonic development [GO:0009791]; regulation of gluconeogenesis [GO:0006111]; response to cold [GO:0009409]; response to starvation [GO:0042594]" axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991] CCRCSLQVLR;MWITNGGKANWYFLLAR 2 6.4 0.92338 -0.4475 0 0 0 0 0 0 0 0 0 10.5899 0 0 P11362 FGFR1_HUMAN Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR Homo sapiens (Human) angiogenesis [GO:0001525]; auditory receptor cell development [GO:0060117]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium ion homeostasis [GO:0055074]; cardiac muscle cell proliferation [GO:0060038]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell projection assembly [GO:0030031]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cementum mineralization [GO:0071529]; chondrocyte differentiation [GO:0002062]; chordate embryonic development [GO:0043009]; diphosphate metabolic process [GO:0071344]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic cell cycle DNA replication [GO:1903465]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell differentiation [GO:0045595]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; regulation of lateral mesodermal cell fate specification [GO:0048378]; regulation of phosphate transport [GO:0010966]; regulation of postsynaptic density assembly [GO:0099151]; response to sodium phosphate [GO:1904383]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; ureteric bud development [GO:0001657]; ventricular zone neuroblast division [GO:0021847]; vitamin D3 metabolic process [GO:0070640] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor-receptor interaction [GO:0090722]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DDVQSINWLR;DLVSCAYQVAR;IADFGLARDIHHIDYYK;MKSGTKK 4 5.5 0.89737 -0.24599 0 0 11.2377 0 8.24203 7.54527 0 0 10.3741 6.01116 0 0 P11362 FGFR1_HUMAN Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR Homo sapiens (Human) angiogenesis [GO:0001525]; auditory receptor cell development [GO:0060117]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium ion homeostasis [GO:0055074]; cardiac muscle cell proliferation [GO:0060038]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell projection assembly [GO:0030031]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cementum mineralization [GO:0071529]; chondrocyte differentiation [GO:0002062]; chordate embryonic development [GO:0043009]; diphosphate metabolic process [GO:0071344]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic cell cycle DNA replication [GO:1903465]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell differentiation [GO:0045595]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; regulation of lateral mesodermal cell fate specification [GO:0048378]; regulation of phosphate transport [GO:0010966]; regulation of postsynaptic density assembly [GO:0099151]; response to sodium phosphate [GO:1904383]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; ureteric bud development [GO:0001657]; ventricular zone neuroblast division [GO:0021847]; vitamin D3 metabolic process [GO:0070640] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor-receptor interaction [GO:0090722]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DLATSPRTSNRGHK 1 4.7 0.8414 -0.048928 0 0 0 0 0 9.2899 0 0 0 0 0 0 P11387 TOP1_HUMAN DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) TOP1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to xenobiotic stimulus [GO:0009410] chromosome [GO:0005694]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993] "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]" AEEVATFFAK;AEEVATFFAKMLDHEYTTK;AVALYFIDK;LALRAGNEK;NLQLFMENKQPEDDLFDRLNTGILNK;VFKNLQLFMENK 6 8.6 0.97523 -3.44 0 0 13.5131 9.98185 0 0 0 0 0 8.66153 12.1161 0 P11388 TOP2A_HUMAN "DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)" TOP2A TOP2 Homo sapiens (Human) apoptotic chromosome condensation [GO:0030263]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA ligation [GO:0006266]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; female meiotic nuclear division [GO:0007143]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of DNA duplex unwinding [GO:1905463]; positive regulation of apoptotic process [GO:0043065]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; resolution of meiotic recombination intermediates [GO:0000712]; rhythmic process [GO:0048511]; sister chromatid segregation [GO:0000819] "chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]" "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]" AYDIAGSTK;EKKDELCR;FTVETASR;LMDGEEPLPMLPSYK;LSVERIYQK;QIMENAEINNIIK;SFGSTCQLSEK;SYVDMYLK;YIFTMLSSLAR 9 6 0.97615 -4.6111 0 12.1723 4.81537 8.71332 0 8.90914 0 9.88295 0 0 10.3306 9.5144 P11413 G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6PD Homo sapiens (Human) "cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; erythrocyte maturation [GO:0043249]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; NADP metabolic process [GO:0006739]; NADPH regeneration [GO:0006740]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of protein glutathionylation [GO:0010734]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to iron(III) ion [GO:0010041]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; substantia nigra development [GO:0021762]" centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] D-glucose binding [GO:0005536]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803] AEQVALSR;DGLLPENTFIVGYAR;WDGVPFILR 3 6.2 0 3.8331 0 0 0 0 0 0 0 0 0 8.51274 0 12.469 P11441 UBL4A_HUMAN Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) UBL4A DXS254E GDX UBL4 Homo sapiens (Human) post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein modification process [GO:0036211]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511] BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-folding chaperone binding [GO:0051087]; ubiquitin-like protein transferase activity [GO:0019787] LNLVVKPLEK;QLVSEKLNVPVRQQR;VLLEEGEAQR 3 22.3 0.95427 -0.95288 0 0 0 0 0 0 0 8.55674 0 0 11.0267 0 P11473 VDR_HUMAN "Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)" VDR NR1I1 Homo sapiens (Human) apoptotic process involved in mammary gland involution [GO:0060057]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; intestinal absorption [GO:0050892]; intracellular calcium ion homeostasis [GO:0006874]; lactation [GO:0007595]; mammary gland branching involved in pregnancy [GO:0060745]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated bile acid signaling pathway [GO:0038185]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of calcidiol 1-monooxygenase activity [GO:0060558]; response to bile acid [GO:1903412]; retinoic acid receptor signaling pathway [GO:0048384]; skeletal system development [GO:0001501]; vitamin D receptor signaling pathway [GO:0070561] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "bile acid nuclear receptor activity [GO:0038186]; calcitriol binding [GO:1902098]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lithocholic acid binding [GO:1902121]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ALFTCPFNGDCRITKDNR;SNESFTMDDMSWTCGNQDYK 2 8.9 0.95516 -0.90149 0 0 0 0 0 0 0 0 9.89254 4.67993 0 0 P11474 ERR1_HUMAN Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) ESRRA ERR1 ESRL1 NR3B1 Homo sapiens (Human) nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" AAGLGELGAALLQLVRRLQALR;AGRLLLTLPLLR;VLAHFYGVKLEGK 3 11.1 0.31481 0.24858 8.4279 0 0 0 0 0 14.7129 0 0 0 10.5011 0 P11487 FGF3_HUMAN Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2) FGF3 INT2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of cardiac muscle tissue development [GO:0055026]; neurogenesis [GO:0022008]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] GRPRRGFK;SSLFLPRVLDHR 2 8.4 0.97496 -3.1593 0 0 0 0 8.33851 0 0 0 0 0 12.7647 0 P11488 GNAT1_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) GNAT1 GNATR Homo sapiens (Human) "adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell population proliferation [GO:0008283]; cellular response to electrical stimulus [GO:0071257]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine secretion [GO:0014046]; eye photoreceptor cell development [GO:0042462]; G protein-coupled opsin signaling pathway [GO:0016056]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; neural tissue regeneration [GO:0097719]; phototransduction, visible light [GO:0007603]; regulation of opsin-mediated signaling pathway [GO:0022400]; response to light stimulus [GO:0009416]; response to organic cyclic compound [GO:0014070]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; sensory perception of umami taste [GO:0050917]; signal transduction [GO:0007165]; visual behavior [GO:0007632]; visual perception [GO:0007601]" apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] acyl binding [GO:0000035]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] LLLLGAGESGK;TTGIIETQFSFKDLNFR;VQFLELNMR 3 10.6 0.95307 -0.67435 0 0 0 0 0 0 9.76241 0 0 0 0 0 P11498 PYC_HUMAN "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Homo sapiens (Human) gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; pyruvate metabolic process [GO:0006090]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736] ADEAYLIGR;ALAVSDLNR;ALAVSDLNRAGQR;FIGPSPEVVR;GLAPVQAYLHIPDIIK;GTPLDTEVPMERVFDYSEYWEGAR;LEYKPIKK;LTSDSVK;TSTAPAASPNVR;TVAIYSEQDTGQMHR;VEGRPGASLPPLDLQALEKELVDR;VLKDLPR 12 12.3 0.95449 -0.91325 12.6594 0 0 9.60118 9.20916 4.98791 12.3141 13.7111 0 8.74692 8.472 6.2107 P11511 CP19A_HUMAN Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) CYP19A1 ARO1 CYAR CYP19 Homo sapiens (Human) androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]; female genitalia development [GO:0030540]; female gonad development [GO:0008585]; mammary gland development [GO:0030879]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of estradiol secretion [GO:2000866]; prostate gland growth [GO:0060736]; response to estradiol [GO:0032355]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]; syncytium formation [GO:0006949]; testosterone biosynthetic process [GO:0061370]; uterus development [GO:0060065] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "aromatase activity [GO:0070330]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]" ALSGPGLVR;DLKDAIEVLIAEK 2 4.4 0.95436 -0.95891 0 0 0 0 0 0 0 0 0 0 0 11.3897 P11532 DMD_HUMAN Dystrophin DMD Homo sapiens (Human) cardiac muscle cell action potential [GO:0086001]; cardiac muscle contraction [GO:0060048]; maintenance of blood-brain barrier [GO:0035633]; motile cilium assembly [GO:0044458]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; muscle organ development [GO:0007517]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; neuron development [GO:0048666]; peptide biosynthetic process [GO:0043043]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cellular response to growth factor stimulus [GO:0090287]; regulation of heart rate [GO:0002027]; regulation of muscle system process [GO:0090257]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of skeletal muscle contraction [GO:0014819]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to muscle stretch [GO:0035994]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536] cell surface [GO:0009986]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]; Z disc [GO:0030018] actin binding [GO:0003779]; dystroglycan binding [GO:0002162]; myosin binding [GO:0017022]; nitric-oxide synthase binding [GO:0050998]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270] ALPEKQGEIEAQIK;AVNRLLQELRAK;DQAANLMANRGDHCR;DSLQQSSGR;ELNDWLTKTEERTR;IDETLER;ITDERKR;KELETLTTNYQWLCTR;KLSSQLVEHCQKLEEQMNK;LASLPEPRDER;LGSLNLRWQEVCK;LHLSLQELLVWLQLK;QQLNEMLK;RQQLNEMLK;VAAAETAK;VLGDRWANICR;VLMDLQNQKLKELNDWLTK;VLQEDLEQEQVR;WIEFCQLLSER;WLNEVEFKLK;YQETMSAIR 21 6.3 0.97811 -6.314 14.4183 0 10.9359 0 11.7863 8.89388 15.312 12.008 14.5304 13.6032 11.0126 0 P11586 C1TC_HUMAN "C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]" MTHFD1 MTHFC MTHFD Homo sapiens (Human) 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; neutrophil homeostasis [GO:0001780]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152]; serine family amino acid biosynthetic process [GO:0009070]; serine family amino acid metabolic process [GO:0009069]; somite development [GO:0061053]; tetrahydrofolate interconversion [GO:0035999]; transsulfuration [GO:0019346] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [GO:0004486] GALALAQAVQR;GVPTGFILPIR;KGEPVSAEDLGVSGALTVLMK;LVPSVNGVR;MFGIPVVVAVNAFK;MVVASSK;QPSQGPTFGIK;TDPTTLTDEEINR;TPVPSDIDISR;VVGDVAYDEAK 10 12.7 0 6.6797 12.0053 10.2343 11.4753 7.82788 8.46911 9.74979 11.7452 11.5881 11.1356 12.511 11.8511 0 P11678 PERE_HUMAN Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule lumen [GO:0034774] heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] FWWQKRGVFTK;IPCFLAGDTRSTETPK;LNLSAWRGT;NQRDCIPFFR;QPVAATRTVVR 5 8 0.9652 -1.1496 0 9.91941 0 8.06738 0 0 0 11.2117 0 9.03395 9.25321 0 P11712 CP2C9_HUMAN Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) CYP2C9 CYP2C10 Homo sapiens (Human) amide metabolic process [GO:0043603]; cholesterol metabolic process [GO:0008203]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; long-chain fatty acid biosynthetic process [GO:0042759]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202]; urea metabolic process [GO:0019627]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "(R)-limonene 6-monooxygenase activity [GO:0052741]; (S)-limonene 6-monooxygenase activity [GO:0018675]; (S)-limonene 7-monooxygenase activity [GO:0018676]; arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate epoxygenase activity [GO:0008392]; caffeine oxidase activity [GO:0034875]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]" NVAFMKSYILEK;QSSGRGKLPPGPTPLPVIGNILQIGIK 2 8 0.072816 0.41627 0 5.50799 0 5.44407 0 0 0 0 9.98911 0 0 0 P11717 MPRI_HUMAN Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) IGF2R MPRI Homo sapiens (Human) animal organ regeneration [GO:0031100]; G protein-coupled receptor signaling pathway [GO:0007186]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; positive regulation by host of viral process [GO:0044794]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; response to retinoic acid [GO:0032526]; response to tetrachloromethane [GO:1904772]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133] D-mannose binding [GO:0005537]; enzyme binding [GO:0019899]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; phosphoprotein binding [GO:0051219]; retinoic acid binding [GO:0001972]; retromer complex binding [GO:1905394]; signaling receptor activity [GO:0038023] IYKGPLGCSER;LTAKSNCR;QGKEGQENGHITTK;TTAACKK;TVEACPVVR 5 2 0.97516 -3.3707 0 0 0 0 0 9.77162 9.50738 0 0 10.0017 0 0 P11766 ADHX_HUMAN Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) ADH5 ADHX FDH Homo sapiens (Human) fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; positive regulation of blood pressure [GO:0045777]; respiratory system process [GO:0003016]; response to lipopolysaccharide [GO:0032496]; response to nitrosative stress [GO:0051409]; response to redox state [GO:0051775]; retinoid metabolic process [GO:0001523] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] alcohol dehydrogenase (NAD+) activity [GO:0004022]; electron transfer activity [GO:0009055]; fatty acid binding [GO:0005504]; formaldehyde dehydrogenase (NAD+) activity [GO:0018467]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity [GO:0106321]; S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity [GO:0051903]; S-nitrosoglutathione reductase (NADH) activity [GO:0080007]; zinc ion binding [GO:0008270] LVSEYMSK;SVESVPK 2 4 0.94977 -0.66518 11.3115 11.6222 4.11753 0 0 0 0 0 0 0 0 0 P11801 KPSH1_HUMAN Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1) PSKH1 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VEPFSGTK;YREGREVCESELR 2 5 0.93038 -0.47776 0 0 0 0 0 0 0 0 0 0 6.16128 8.84266 P11802 CDK4_HUMAN Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) CDK4 Homo sapiens (Human) cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; chromatin [GO:0000785]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D2-CDK4 complex [GO:0097129]; cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein serine kinase activity [GO:0106310] EIKVTLVFEHVDQDLR;LADFGLAR;SVRVPNGGGGGGGLPISTVR 3 14.5 0.95547 -0.86003 0 0 0 0 0 0 0 11.2152 10.0242 0 0 0 P11912 CD79A_HUMAN B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a) CD79A IGA MB1 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853] B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; IgM B cell receptor complex [GO:0071755]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] QPPPRPFLDMGEGTKNR 1 7.5 0.98 -1.5672 0 0 0 0 0 0 12.4226 0 0 9.59872 0 0 P11926 DCOR_HUMAN Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 Homo sapiens (Human) cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829] ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803] VTPFYAVKCNDSKAIVK;WLKALPR 2 5.2 0.91641 -0.34421 0 0 0 0 0 7.69439 0 0 0 0 0 8.89339 P11940 PABP1_HUMAN Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP PABP1 PABPC2 Homo sapiens (Human) "CRD-mediated mRNA stabilization [GO:0070934]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulatory ncRNA-mediated gene silencing [GO:0031047]" catalytic step 2 spliceosome [GO:0071013]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; translation activator activity [GO:0008494] ALDTMNFDVIK;AVNSATGVPTV;AVTEMNGR;EFSPFGTITSAK;EFTNVYIK;FEQMKQDR;FSPAGPILSIR;IVATKPLYVALAQR;KFEQMKQDR;NLDDGIDDER;SGVGNIFIK;SLGYAYVNFQQPADAER;TVPQYKYAAGVR;YQGVNLYVK 14 22.2 0 6.6084 11.8027 11.7671 12.903 9.17218 10.0715 9.35823 13.3457 0 12.9281 11.5813 11.6886 11.5884 P12004 PCNA_HUMAN Proliferating cell nuclear antigen (PCNA) (Cyclin) PCNA Homo sapiens (Human) "base-excision repair, gap-filling [GO:0006287]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; epithelial cell differentiation [GO:0030855]; estrous cycle [GO:0044849]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; liver regeneration [GO:0097421]; mismatch repair [GO:0006298]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of deoxyribonuclease activity [GO:0032077]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; replication fork processing [GO:0031297]; response to cadmium ion [GO:0046686]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to L-glutamate [GO:1902065]; translesion synthesis [GO:0019985]" "centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear lamina [GO:0005652]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]; replication fork [GO:0005657]; replisome [GO:0030894]" chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; nuclear estrogen receptor binding [GO:0030331]; protein-containing complex binding [GO:0044877]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971] AEDNADTLALVFEAPNQEK;FSASGELGNGNIK;IADMGHLKYYLAPKIEDEEGS;MPSGEFAR;NLAMGVNLTSMSK;SEGFDTYR;VSDYEMK;YLNFFTK 8 36.8 0 4.9026 11.8223 10.8908 12.1174 7.7763 9.71359 9.36078 0 0 6.56067 11.2593 10.1163 10.4532 P12035 K2C3_HUMAN "Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)" KRT3 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] AGGFGGGR;FASFIDK;FASFIDKVR;FLEQQNK;FLEQQNKVLETK;LDSELKNMEDLVEDFKK;LGELQTTAGR;LGELQTTAGRHGDDLR;LRAEIEGVK;SLYNLGGNK 10 12.7 0.98033 -1.5962 0 0 0 0 0 0 0 0 0 11.3446 11.3555 0 P12036 NFH_HUMAN Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) NEFH KIAA0845 NFH Homo sapiens (Human) axon development [GO:0061564]; axonogenesis [GO:0007409]; cell projection assembly [GO:0030031]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament bundle assembly [GO:0045110]; microtubule cytoskeleton organization [GO:0000226]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; peripheral nervous system neuron axonogenesis [GO:0048936]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of organelle transport along microtubule [GO:1902513] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic density [GO:0014069]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685] dynein complex binding [GO:0070840]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184] ATEDKAAK;EYQDLLNVK;QLQARTTELEALK;SLEGEAAALRQQQAGR;SPAEAKSPEK 5 6.5 0.96409 -1.1147 10.4679 9.35669 0 10.7057 0 0 0 8.56026 0 7.63307 0 0 P12081 HARS1_HUMAN "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" HARS1 HARS HRS Homo sapiens (Human) histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] FRTICSSVDKLDK;IFSIVEQR;ILDGMFAICGVSDSK;KVPCVGLSIGVER;LEALEEK;SVTSREEVDVRR;TICSSVDK;TICSSVDKLDK;VSWEEVK;YDLTVPFAR 10 16.5 0.97545 -4.2804 0 12.2141 11.8572 9.48961 9.76573 9.82439 13.3796 13.0987 13.2427 10.6031 11.02 13.2009 P12107 COBA1_HUMAN Collagen alpha-1(XI) chain COL11A1 COLL6 Homo sapiens (Human) cartilage condensation [GO:0001502]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; embryonic skeletal system morphogenesis [GO:0048704]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; ossification [GO:0001503]; proteoglycan metabolic process [GO:0006029]; sensory perception of sound [GO:0007605]; tendon development [GO:0035989]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visual perception [GO:0007601] collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] AAYDYCEHYSPDCDSSAPK;FTPPKSEK;GETGFQGK;GLPGTQGSPGAK;QDIEHMKFPMGTQTNPARTCK 5 3.7 0.98103 -1.6967 0 0 0 0 7.43721 0 0 9.68192 0 7.7922 0 0 P12109 CO6A1_HUMAN Collagen alpha-1(VI) chain COL6A1 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; adipose tissue development [GO:0060612]; apoptotic nuclear changes [GO:0030262]; autophagy [GO:0006914]; basement membrane organization [GO:0071711]; bone development [GO:0060348]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; caveola assembly [GO:0070836]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cellular response to amino acid stimulus [GO:0071230]; circadian rhythm [GO:0007623]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endodermal cell differentiation [GO:0035987]; energy reserve metabolic process [GO:0006112]; extracellular matrix assembly [GO:0085029]; fat cell proliferation [GO:0070341]; gene expression [GO:0010467]; glycolytic process [GO:0006096]; hair follicle development [GO:0001942]; heart development [GO:0007507]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; limb joint morphogenesis [GO:0036022]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; lung morphogenesis [GO:0060425]; mitochondrial depolarization [GO:0051882]; mitochondrial transmembrane transport [GO:1990542]; mitochondrion organization [GO:0007005]; multicellular organismal locomotion [GO:0071965]; muscle cell apoptotic process [GO:0010657]; muscle system process [GO:0003012]; myelination in peripheral nervous system [GO:0022011]; neuron apoptotic process [GO:0051402]; osteoblast differentiation [GO:0001649]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein tetramerization [GO:0051262]; reactive oxygen species metabolic process [GO:0072593]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of cell size [GO:0008361]; regulation of collagen fibril organization [GO:1904026]; respiratory system process [GO:0003016]; response to bleomycin [GO:1904975]; response to decreased oxygen levels [GO:0036293]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; response to pain [GO:0048265]; response to peptide [GO:1901652]; response to polyamine macromolecule [GO:1904583]; response to reactive oxygen species [GO:0000302]; response to toxic substance [GO:0009636]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of mechanical stimulus [GO:0050954]; single fertilization [GO:0007338]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue growth [GO:0048630]; skeletal muscle tissue regeneration [GO:0043403]; tissue remodeling [GO:0048771]; transmission of nerve impulse [GO:0019226]; tricarboxylic acid cycle [GO:0006099]; uterus development [GO:0060065] basement membrane [GO:0005604]; collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular vesicle [GO:0097708]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] EPCGGLEDAVNEAK;GAPGINGTKGYPGLK;GVFHQTVSRK 3 3.8 0.95565 -0.86842 6.67412 0 0 0 9.60266 0 0 0 9.03738 0 0 0 P12110 CO6A2_HUMAN Collagen alpha-2(VI) chain COL6A2 Homo sapiens (Human) cell adhesion [GO:0007155]; neuron apoptotic process [GO:0051402]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; response to glucose [GO:0009749]; response to UV [GO:0009411] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383] collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020] AAVFHEK;ETCGCCDCEK;ETCGCCDCEKR;GAPGLAGKNGTDGQKGK;GEKGEFGADGR;SPRGGAR 6 5.2 0.97243 -2.7602 11.7935 11.1274 0 0 0 5.50478 0 0 0 0 0 12.2332 P12111 CO6A3_HUMAN Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) cell adhesion [GO:0007155]; muscle organ development [GO:0007517]; neuron apoptotic process [GO:0051402]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; response to glucose [GO:0009749]; response to UV [GO:0009411] collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; sarcolemma [GO:0042383] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] DSFQEVLR;DVVLSIVNDLTIAESNCPR;GLEYIMQSHLTKAAGSR;IASNSATAFR;SLDEISQPAQELK;VSCSGGR;VVESLDVGQDRVR 7 2.7 0.98045 -1.6796 0 10.6855 0 0 0 8.95332 0 8.26299 8.57149 11.7012 8.94872 0 P12259 FA5_HUMAN "Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]" F5 Homo sapiens (Human) blood circulation [GO:0008015]; blood coagulation [GO:0007596]; response to vitamin K [GO:0032571] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] copper ion binding [GO:0005507] AEVDDVIQVR;KVMYTQYEDESFTK;LNAQGRVNAWQAKANNNK;LTSSEMK;TNINSSR 5 2.5 0.95235 -0.72311 7.4219 12.3256 5.98293 0 11.7671 7.15623 0 0 0 9.33045 0 0 P12268 IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) IMPDH2 IMPD2 Homo sapiens (Human) 'de novo' XMP biosynthetic process [GO:0097294]; cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; lymphocyte proliferation [GO:0046651] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] DYPLASK;EANEILQR;EANEILQRSK;NLIDAGVDALR 4 5.4 0.96749 -1.3212 0 0 4.82038 10.2704 0 0 0 0 8.58451 0 0 0 P12270 TPR_HUMAN Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631] AAVLQQVLER;ELENANDLLSATKRK;ETLNQAETKSK;IQQLTEEIGR;KAIVAAK;LQEDTDKANK;LQEQVTDLR;NIAIQSQFTR;QEQIINTMTQDLR;SQYEGRISR;TDELLALGR;TLSEKETEAR;VTAAAMAGNK 13 5.6 0 5.2066 14.1516 0 5.88448 0 0 9.86006 10.7025 9.51276 9.69316 11.1455 8.52493 0 P12273 PIP_HUMAN Prolactin-inducible protein (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (Secretory actin-binding protein) (SABP) (gp17) PIP GCDFP15 GPIP4 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] actin binding [GO:0003779]; aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; IgG binding [GO:0019864] AQDNTRK 1 4.8 0.91673 -0.41013 0 0 0 0 0 0 0 0 0 11.9155 0 0 P12277 KCRB_HUMAN Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) CKB CKBB Homo sapiens (Human) futile creatine cycle [GO:0140651]; phosphocreatine biosynthetic process [GO:0046314]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; ubiquitin protein ligase binding [GO:0031625] AGVHIKLPNLGKHEK;FCTGLTQIETLFK;GIWHNDNK;GTGGVDTAAVGGVFDVSNADR;LAVEALSSLDGDLAGR;LAVEALSSLDGDLAGRYYALK;PFSNSHNALK;TDLNPDNLQGGDDLDPNYVLSSR 8 29.1 0 66.666 13.6853 13.4799 13.4205 10.0334 11.0775 8.26669 5.09149 4.44022 8.51373 0 0 0 P12318 FCG2A_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32) FCGR2A CD32 FCG2 FCGR2A1 IGFR2 Homo sapiens (Human) antibody-dependent cellular cytotoxicity [GO:0001788]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of tumor necrosis factor production [GO:0032760] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] IgG binding [GO:0019864]; IgG receptor activity [GO:0019770] ISANSTDPVK 1 3.2 0.89851 -0.23381 0 0 0 0 0 9.65941 0 0 0 0 0 0 P12319 FCERA_HUMAN High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) FCER1A FCE1A Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; eosinophil degranulation [GO:0043308]; immunoglobulin mediated immune response [GO:0016064]; mast cell degranulation [GO:0043303]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] high-affinity IgE receptor activity [GO:0019768]; IgE binding [GO:0019863] LLNPHPKPNPKNN 1 5.1 0.92114 -0.44475 0 0 0 0 0 8.3554 0 0 0 0 0 0 P12429 ANXA3_HUMAN "Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)" ANXA3 ANX3 Homo sapiens (Human) animal organ regeneration [GO:0031100]; defense response to bacterium [GO:0042742]; hippocampus development [GO:0021766]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834] ASIWVGHR;DYPDFSPSVDAEAIQK;EYQAAYGK;GAGTNEDALIEILTTR;GIGTDEFTLNR;LTFDEYR;NTPAFLAER;SEIDLLDIR 8 26 0 2.5364 12.9776 12.8377 12.8488 0 0 0 11.2427 0 12.0737 7.85044 0 0 P12524 MYCL_HUMAN Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) MYCL BHLHE38 LMYC MYCL1 Homo sapiens (Human) regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FPPESCSQEEASER;GPQEEVLER 2 6.3 0.94432 -0.63513 0 0 0 2.54458 0 0 0 0 0 0 0 0 P12524 MYCL_HUMAN Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) MYCL BHLHE38 LMYC MYCL1 Homo sapiens (Human) regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLPEPSK 1 3 0.90955 -0.31528 0 9.2124 0 0 0 0 0 0 7.16621 0 0 0 P12532 KCRU_HUMAN "Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)" CKMT1A CKMT; CKMT1B CKMT Homo sapiens (Human) phosphocreatine biosynthetic process [GO:0046314] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] AGVHIKLPLLSKDSR 1 3.6 0.95898 -1.0399 0 0 0 8.74167 9.03282 0 0 0 0 10.2509 0 0 P12644 BMP4_HUMAN Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) BMP4 BMP2B DVR4 Homo sapiens (Human) ameloblast differentiation [GO:0036305]; anterior/posterior axis specification [GO:0009948]; aortic valve morphogenesis [GO:0003180]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus development [GO:0060433]; bud dilation involved in lung branching [GO:0060503]; bud elongation involved in lung branching [GO:0060449]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum development [GO:0003279]; cellular response to BMP stimulus [GO:0071773]; chondrocyte differentiation [GO:0002062]; coronary vasculature development [GO:0060976]; cranial suture morphogenesis [GO:0060363]; deltoid tuberosity development [GO:0035993]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion development [GO:0003197]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal cell signaling [GO:0060684]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; glomerular capillary formation [GO:0072104]; heart induction [GO:0003129]; heart morphogenesis [GO:0003007]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear auditory receptor cell differentiation [GO:0042491]; intermediate mesodermal cell differentiation [GO:0048392]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage differentiation [GO:0030225]; mammary gland formation [GO:0060592]; membranous septum morphogenesis [GO:0003149]; mesodermal cell fate determination [GO:0007500]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; monocyte differentiation [GO:0030224]; negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of glomerulus development [GO:0090194]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200]; negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007]; negative regulation of metanephric S-shaped body morphogenesis [GO:2000005]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; neuron fate commitment [GO:0048663]; odontogenesis [GO:0042476]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; pericyte cell differentiation [GO:1904238]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cardiac muscle fiber development [GO:0055020]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; prostatic bud formation [GO:0060513]; pulmonary valve morphogenesis [GO:0003184]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell fate commitment [GO:0010453]; regulation of mesodermal cell differentiation [GO:1905770]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein import into nucleus [GO:0042306]; regulation of smooth muscle cell differentiation [GO:0051150]; renal system process [GO:0003014]; secondary heart field specification [GO:0003139]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; specification of animal organ position [GO:0010159]; stem cell differentiation [GO:0048863]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; tendon cell differentiation [GO:0035990]; trachea development [GO:0060438]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell development [GO:0003323]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; chemoattractant activity [GO:0042056]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein serine/threonine kinase activator activity [GO:0043539] SAVIPDYMRDLYR 1 3.2 0.9211 -0.4462 0 0 0 0 0 0 0 0 4.25686 0 0 0 P12645 BMP3_HUMAN Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin) BMP3 BMP3A Homo sapiens (Human) cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; negative regulation of ossification [GO:0030279]; osteoblast differentiation [GO:0001649]; skeletal system development [GO:0001501] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] KPYKTLQAQAPEK;TAGGGPDSELQPQDK 2 5.9 0.9413 -0.59797 3.10289 0 0 0 0 0 0 0 0 0 0 0 P12724 ECP_HUMAN Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3) RNASE3 ECP RNS3 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540] RFYVVACDNRDPR 1 8.1 0.86771 -0.091701 0 0 0 0 6.67257 0 0 0 0 0 0 0 P12755 SKI_HUMAN Ski oncogene (Proto-oncogene c-Ski) SKI Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell proliferation [GO:0060038]; cell motility [GO:0048870]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; lens morphogenesis in camera-type eye [GO:0002089]; myelination in peripheral nervous system [GO:0022011]; myotube differentiation [GO:0014902]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neural tube closure [GO:0001843]; nose morphogenesis [GO:0043585]; olfactory bulb development [GO:0021772]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; retina development in camera-type eye [GO:0060041]; roof of mouth development [GO:0060021]; skeletal muscle fiber development [GO:0048741]; somatic stem cell population maintenance [GO:0035019]; transforming growth factor beta receptor signaling pathway [GO:0007179] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase inhibitor activity [GO:0046811]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" DSFYSYK;EAKEKFLHEVVK;EAREHLEK;EREAREHLEK;KEIERLR;LGRCLDDVKEK;MRVKQEEK;SLGCVHPR 8 8.7 0.97554 -4.3768 0 7.63445 14.1141 5.69315 0 12.3974 0 0 0 6.0054 10.1689 12.216 P12757 SKIL_HUMAN Ski-like protein (Ski-related oncogene) (Ski-related protein) SKIL SNO Homo sapiens (Human) blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axonogenesis [GO:0050772]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; response to antibiotic [GO:0046677]; response to cytokine [GO:0034097]; response to growth factor [GO:0070848]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" IMEEVMR;LEMMIKELK;MENLQTNFSLVQGSTKK;SMKELTEEQQNLQK;TVSYPDVSLEEQEKMDLKTSR 5 9.9 0.96132 -1.065 11.501 0 0 10.2984 0 0 0 0 0 7.73545 9.92078 0 P12757 SKIL_HUMAN Ski-like protein (Ski-related oncogene) (Ski-related protein) SKIL SNO Homo sapiens (Human) blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axonogenesis [GO:0050772]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; response to antibiotic [GO:0046677]; response to cytokine [GO:0034097]; response to growth factor [GO:0070848]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" IMEEVMR;LEMMIKELK;MENLQTNFSLVQGSTKK;SMKELTEEQQNLQK;TEANASISNNSTSKR 5 9.7 0.58903 0.17901 10.7752 0 0 0 0 0 0 0 0 0 0 0 P12814 ACTN1_HUMAN Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) ACTN1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981] brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; vinculin binding [GO:0017166] ALDFIASK;ASIHEAWTDGK;DHYDSQQTNDYMQPEEDWDR;DLLLDPAWEK;FAIQDISVEETSAK;LDHLAEK;LDHLAEKFR;QKDYETATLSEIK;TFTAWCNSHLRK;TINEVENQILTR;VGWEQLLTTIAR 11 13.6 0.90978 -0.31549 0 0 5.4521 0 0 0 0 0 0 0 0 10.7296 P12821 ACE_HUMAN "Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" ACE DCP DCP1 Homo sapiens (Human) amyloid-beta metabolic process [GO:0050435]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; angiotensin maturation [GO:0002003]; angiotensin-activated signaling pathway [GO:0038166]; animal organ regeneration [GO:0031100]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; arachidonate secretion [GO:0050482]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; bradykinin catabolic process [GO:0010815]; cell proliferation in bone marrow [GO:0071838]; cellular response to aldosterone [GO:1904045]; cellular response to glucose stimulus [GO:0071333]; eating behavior [GO:0042755]; embryo development ending in birth or egg hatching [GO:0009792]; female pregnancy [GO:0007565]; heart contraction [GO:0060047]; hematopoietic stem cell differentiation [GO:0060218]; hormone catabolic process [GO:0042447]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; male gonad development [GO:0008584]; mononuclear cell proliferation [GO:0032943]; negative regulation of calcium ion import [GO:0090281]; negative regulation of D-glucose import [GO:0046325]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neurogenesis [GO:0050769]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; proteolysis [GO:0006508]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of renal output by angiotensin [GO:0002019]; regulation of smooth muscle cell migration [GO:0014910]; regulation of synaptic plasticity [GO:0048167]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; response to dexamethasone [GO:0071548]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; substance P catabolic process [GO:0010814]; vasoconstriction [GO:0042310] basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] actin binding [GO:0003779]; bradykinin receptor binding [GO:0031711]; calmodulin binding [GO:0005516]; carboxypeptidase activity [GO:0004180]; chloride ion binding [GO:0031404]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; heterocyclic compound binding [GO:1901363]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidase activity [GO:0008233]; peptidyl-dipeptidase activity [GO:0008241]; tripeptidyl-peptidase activity [GO:0008240]; zinc ion binding [GO:0008270] IAFIPFSYLVDQWRWR;TATCWSLDPDLTNILASSR;YFVSFVLQFQFHEALCK 3 4 0.89254 -0.22281 0 6.61008 4.86557 0 0 0 0 0 0 0 6.93204 7.63401 P12830 CADH1_HUMAN Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] CDH1 CDHE UVO Homo sapiens (Human) "adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cellular response to indole-3-methanol [GO:0071681]; cellular response to lithium ion [GO:0071285]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; neuron projection development [GO:0031175]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; protein localization to plasma membrane [GO:0072659]; regulation of gene expression [GO:0010468]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to Gram-positive bacterium [GO:0140459]; response to heparin [GO:0071503]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]" actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; desmosome [GO:0030057]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; flotillin complex [GO:0016600]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802] ankyrin binding [GO:0030506]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; gamma-catenin binding [GO:0045295]; GTPase activating protein binding [GO:0032794]; identical protein binding [GO:0042802]; protein tyrosine kinase binding [GO:1990782] ETGWLKVTEPLDR;TAKGLDFEAK 2 2.6 0.97908 -1.8893 0 0 0 9.95174 0 0 0 0 0 6.12402 0 0 P12838 DEF4_HUMAN Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4) DEFA4 DEF4 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; disruption of plasma membrane integrity in another organism [GO:0051673]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640] azurophil granule [GO:0042582]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; specific granule lumen [GO:0035580]; transport vesicle [GO:0030133] protein homodimerization activity [GO:0042803] IIALLAAILLVALQVR;RIIALLAAILLVALQVR;RIIALLAAILLVALQVRAGPLQAR 3 24.7 0.89265 -0.22259 5.76755 0 0 0 0 0 0 0 0 0 3.95354 0 P12882 MYH1_HUMAN "Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)" MYH1 Homo sapiens (Human) muscle contraction [GO:0006936] A band [GO:0031672]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intercalated disc [GO:0014704]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] AKSALAHALQSSRHDCDLLR;ALQEAHQQTLDDLQAEEDK;AMSKANSEVAQWR;ELEEKMVTLMQEK;ESIFCIQYNVR;ILRIQLELNQVKSEVDR;ILYADFKQR;ILYADFKQRYK;MVTLMQEK;VQLLHTQNTSLINTKK 10 6.2 0.97678 -5.5601 0 0 7.13504 0 8.70224 10.6371 0 10.5143 0 0 0 12.5639 P12883 MYH7_HUMAN "Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)" MYH7 MYHCB Homo sapiens (Human) adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of heart rate [GO:0002027]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of skeletal muscle contraction [GO:0014728]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; striated muscle contraction [GO:0006941]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] AERDYHIFYQILSNK;AKLFDNHLGKSANFQKPR;ANLEKMCR;GVLARMEYK;KMDADLSQLQTEVEEAVQECRNAEEK;LEAQTRPFDLK;LTGAIMHFGNMKFK;QVKSLQSLLK;TLEDQMNEHRSK 9 6.4 0.97499 -3.4497 12.7215 9.7701 10.6678 0 0 0 6.81506 0 0 6.77255 0 8.31538 P12931 SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC SRC1 Homo sapiens (Human) adherens junction organization [GO:0034332]; angiotensin-activated signaling pathway [GO:0038166]; bone resorption [GO:0045453]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cellular response to fatty acid [GO:0071398]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to progesterone stimulus [GO:0071393]; cellular response to prolactin [GO:1990646]; cellular response to reactive oxygen species [GO:0034614]; DNA biosynthetic process [GO:0071897]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2 signaling pathway [GO:0038128]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; leukocyte migration [GO:0050900]; macroautophagy [GO:0016236]; myoblast proliferation [GO:0051450]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurotrophin TRK receptor signaling pathway [GO:0048011]; odontogenesis [GO:0042476]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cytokine production [GO:0001819]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of integrin activation [GO:0033625]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein processing [GO:0010954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein transport [GO:0051222]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; primary ovarian follicle growth [GO:0001545]; progesterone receptor signaling pathway [GO:0050847]; protein autophosphorylation [GO:0046777]; protein destabilization [GO:0031648]; regulation of bone resorption [GO:0045124]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell projection assembly [GO:0060491]; regulation of cell-cell adhesion [GO:0022407]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of epithelial cell migration [GO:0010632]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of toll-like receptor 3 signaling pathway [GO:0034139]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]; response to electrical stimulus [GO:0051602]; response to interleukin-1 [GO:0070555]; response to mechanical stimulus [GO:0009612]; response to mineralocorticoid [GO:0051385]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; skeletal muscle cell proliferation [GO:0014856]; spermatogenesis [GO:0007283]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; T cell costimulation [GO:0031295]; transcytosis [GO:0045056]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] "actin filament [GO:0005884]; caveola [GO:0005901]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic specialization, intracellular component [GO:0099091]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060]" ATP binding [GO:0005524]; ATPase binding [GO:0051117]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; connexin binding [GO:0071253]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; heme binding [GO:0020037]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor binding [GO:0005158]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; nuclear estrogen receptor binding [GO:0030331]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] EVLDQVER;LIEDNEYTAR 2 3.4 0.96518 -1.2166 0 0 0 0 0 0 0 0 0 13.966 0 0 P12955 PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) PEPD PRD Homo sapiens (Human) amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] extracellular exosome [GO:0070062] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; proline dipeptidase activity [GO:0102009] AAATGPSFWLGNETLK;FTADQKAVYEAVLRSSR;TDMELEVLR;VFKTDMELEVLR 4 9.1 0.97305 -2.5198 0 0 0 0 10.2722 0 12.2023 0 11.5519 0 0 11.6951 P12956 XRCC6_HUMAN X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) XRCC6 G22P1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA ligation [GO:0006266]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; secretory granule lumen [GO:0034774]; transcription regulator complex [GO:0005667]" "5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin binding [GO:0030332]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]" DSLIFLVDASK;FTVPMLK;IMATPEQVGK;NIYVLQELDNPGAK;NLEALALDLMEPEQAVDLTLPK;TEGDEEAEEEQEENLEASGDYK;TFNTSTGGLLLPSDTKR;VEAMNKR;VEAMNKRLGSLVDEFK 9 19.5 0 32.081 13.3382 13.633 12.6409 12.0681 10.9848 10.7525 0 0 0 12.3245 10.9301 12.5009 P13010 XRCC5_HUMAN X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) XRCC5 G22P2 Homo sapiens (Human) "activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to xenobiotic stimulus [GO:0009410]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]" "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA end binding [GO:0045027]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625]" AFREEAIK;ANPQVGVAFPHIK;EEASGSSVTAEEAK;EPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIK;FFMGNQVLK;IKTLFPLIEAKK;MVRSGNK;QVFAENK;SQIPLSK;TDTLEDLFPTTK;TLFPLIEAK;TWTVVDAK;VDEEQMKYK;VITMFVQR;YAPTEAQLNAVDALIDSMSLAK;YGSDIVPFSK;YGSDIVPFSKVDEEQMK 17 23.1 0 4.8187 14.4876 13.224 13.2701 11.3257 10.6833 11.6979 9.47549 0 12.4007 11.811 11.3655 13.0266 P13051 UNG_HUMAN Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG DGU UNG1 UNG15 Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; isotype switching [GO:0045190]; negative regulation of apoptotic process [GO:0043066]; single strand break repair [GO:0000012]; somatic hypermutation of immunoglobulin genes [GO:0016446]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] damaged DNA binding [GO:0003684]; ribosomal small subunit binding [GO:0043024]; uracil DNA N-glycosylase activity [GO:0004844] GVFCLGPWGLGR 1 3.9 0.80615 0.012201 0 0 0 0 0 0 10.1613 0 0 0 0 0 P13056 NR2C1_HUMAN Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) NR2C1 TR2 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; PML body [GO:0016605] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor activity [GO:0038023]; zinc ion binding [GO:0008270]" AFDTLAK;LSRLLLRLPALR 2 3.2 0.86987 -0.098657 0 0 0 0 0 4.22728 0 0 8.71208 0 0 0 P13073 COX41_HUMAN "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)" COX4I1 COX4 Homo sapiens (Human) "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129] DHPLPEVAHVK;VFSLVGK 2 10.7 0.94436 -0.6402 0 0 0 0 0 0 0 0 9.95564 0 0 0 P13232 IL7_HUMAN Interleukin-7 (IL-7) IL7 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; B cell proliferation [GO:0042100]; bone resorption [GO:0045453]; cell-cell signaling [GO:0007267]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; interleukin-7-mediated signaling pathway [GO:0038111]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; organ growth [GO:0035265]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell differentiation [GO:0045582]; T cell lineage commitment [GO:0002360] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-7 receptor binding [GO:0005139] SLEENKSLKEQK 1 9 0.86985 -0.094577 0 0 0 0 0 0 0 0 0 0 0 6.48795 P13349 MYF5_HUMAN Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2) MYF5 BHLHC2 Homo sapiens (Human) camera-type eye development [GO:0043010]; cartilage condensation [GO:0001502]; embryonic skeletal system morphogenesis [GO:0048704]; extracellular matrix organization [GO:0030198]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle tissue morphogenesis [GO:0060415]; ossification [GO:0001503]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CTTTNPNQRLPK;VNQAFETLK 2 8.2 0.965 -1.1637 0 0 0 0 0 0 0 11.7192 0 0 0 0 P13489 RINI_HUMAN Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) RNH1 PRI RNH Homo sapiens (Human) cell migration [GO:0016477]; mRNA catabolic process [GO:0006402]; regulation of angiogenesis [GO:0045765]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; tRNA stabilization [GO:0036416] angiogenin-PRI complex [GO:0032311]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ribonuclease inhibitor activity [GO:0008428] LEDAGVR;VNPALAELNLR 2 3.9 0.75161 0.079681 0 0 0 0 0 0 0 0 10.7106 8.92202 9.04868 0 P13497 BMP1_HUMAN Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 PCOLC Homo sapiens (Human) cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; ossification [GO:0001503]; positive regulation of cartilage development [GO:0061036]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] HWEKHTCVTFLER 1 1.3 0.92234 -0.44712 0 0 0 0 0 0 0 0 0 0 0 5.45227 P13500 CCL2_HUMAN C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2) CCL2 MCP1 SCYA2 Homo sapiens (Human) "angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; astrocyte cell migration [GO:0043615]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular homeostasis [GO:0019725]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; helper T cell extravasation [GO:0035684]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of natural killer cell chemotaxis [GO:2000502]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; response to bacterium [GO:0009617]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; viral genome replication [GO:0019079]" extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR2 chemokine receptor binding [GO:0031727]; chemokine activity [GO:0008009]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102] CPKEAVIFK 1 9.1 0.6079 0.17645 8.42114 0 0 0 0 0 0 7.67546 0 0 0 0 P13521 SCG2_HUMAN Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] SCG2 CHGC Homo sapiens (Human) angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; eosinophil chemotaxis [GO:0048245]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell proliferation [GO:0001938]; protein secretion [GO:0009306] endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141] chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125] LYTDDEDDIYK;YPEIINSNQVKR 2 3.7 0.73284 0.11873 0 0 0 0 0 7.08576 0 0 0 6.64347 0 0 P13533 MYH6_HUMAN "Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)" MYH6 MYHCA Homo sapiens (Human) adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; regulation of blood pressure [GO:0008217]; regulation of heart contraction [GO:0008016]; regulation of heart growth [GO:0060420]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral muscle development [GO:0007522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]; protein kinase binding [GO:0019901] ELEGELEAEQKRNAESVK;ELTYQTEEDKK;IVERRDALLVIQWNIR;LQTENGELARQLEEK;LQTENGELARQLEEKEALISQLTR;LYDNHLGK;QVKSLQSLLK 7 4.5 0.96352 -1.1057 0 11.7253 6.81737 0 0 0 0 0 10.0153 7.17483 0 9.04018 P13535 MYH8_HUMAN "Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)" MYH8 Homo sapiens (Human) ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle contraction [GO:0003009] cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; myosin phosphatase activity [GO:0017018]; structural constituent of muscle [GO:0008307] HQLEEETK;ILRIQLELNQVKSEVDR;LYDQHLGK;SNAACAALDKK;TKDELAKSEAK;TLASLFSTYASAEADSSAKK;VQLLHTQNTSLINTKK 7 4.7 0.9785 -2.1171 8.61552 0 0 0 0 10.5708 0 0 0 10.2622 0 0 P13569 CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) CFTR ABCC7 Homo sapiens (Human) amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; chloride transmembrane transport [GO:1902476]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of cyclic nucleotide-gated ion channel activity [GO:1902161]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of voltage-gated chloride channel activity [GO:1902943]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; transmembrane transport [GO:0055085]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] 14-3-3 protein binding [GO:0071889]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; chloride channel regulator activity [GO:0017081]; chloride transmembrane transporter activity [GO:0015108]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138] ASVVSKLFFSWTRPILRK;GNSTHSR 2 1.7 0.16619 0.34563 0 0 0 0 0 0 0 5.70354 0 0 6.44541 0 P13584 CP4B1_HUMAN Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP) CYP4B1 Homo sapiens (Human) biphenyl metabolic process [GO:0018879]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; heterocyclic compound binding [GO:1901363]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]" LIHLLLR 1 1.4 0.91421 -0.3362 0 0 0 0 0 0 0 0 1.72622 0 0 0 P13591 NCAM1_HUMAN Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) NCAM1 NCAM Homo sapiens (Human) cell adhesion [GO:0007155]; commissural neuron axon guidance [GO:0071679]; epithelial to mesenchymal transition [GO:0001837]; regulation of semaphorin-plexin signaling pathway [GO:2001260] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] virus receptor activity [GO:0001618] AVGEEVWHSK;DISWFSPNGEK 2 2.4 0.93443 -0.50378 0 0 0 0 0 6.13243 0 0 0 8.38716 0 0 P13598 ICAM2_HUMAN Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102) ICAM2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609] cleavage furrow [GO:0032154]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; uropod [GO:0001931] integrin binding [GO:0005178] AAWRRLPQAFRP;GNETLHYETFGK 2 8.7 0.98048 -1.7214 0 0 10.7685 0 0 0 0 0 0 0 0 0 P13611 CSPG2_HUMAN Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell recognition [GO:0008037]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; interphotoreceptor matrix [GO:0033165]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; perineuronal net [GO:0072534]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; hyaluronic acid binding [GO:0005540]; protein tyrosine phosphatase activator activity [GO:0008160] DGFIQRHLPTIR;ITCMNPSAYQR;ITEEFLGK;QEIESETTSEEQIQEEK;YFAHRRTWDAAER 5 1.8 0.9629 -1.1002 0 0 10.1241 0 0 0 0 0 0 0 8.14552 0 P13612 ITA4_HUMAN Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) ITGA4 CD49D Homo sapiens (Human) axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of protein homodimerization activity [GO:0090074]; negative regulation of vasoconstriction [GO:0045906]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein antigen binding [GO:1990405] AYIFSIDEK;FGSYLGYSVGAGHFR;ILELEEK 3 3 0.9157 -0.37172 0 0 6.15727 0 0 0 0 9.88203 0 0 0 9.5093 P13631 RARG_HUMAN Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) RARG NR1B3 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; face development [GO:0060324]; glandular epithelial cell development [GO:0002068]; growth plate cartilage chondrocyte growth [GO:0003430]; Harderian gland development [GO:0070384]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell size [GO:0008361]; regulation of myelination [GO:0031641]; regulation of myeloid cell differentiation [GO:0045637]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; stem cell proliferation [GO:0072089]; trachea cartilage development [GO:0060534] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" GGLKSPA 1 1.5 0.74066 0.10656 0 0 0 0 0 0 0 0 0 0 9.25349 0 P13637 AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) ATP1A3 Homo sapiens (Human) cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to amyloid-beta [GO:1904646]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; neuron projection maintenance [GO:1990535]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of resting membrane potential [GO:0060075]; response to glycoside [GO:1903416]; sodium ion export across plasma membrane [GO:0036376] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; organelle membrane [GO:0031090]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein-folding chaperone binding [GO:0051087]; steroid hormone binding [GO:1990239] AAVPDAVGK;AAVPDAVGKCR;GFAFDCDDVNFTTDNLCFVGLMSMIDPPR;GVGIISEGNETVEDIAAR;LNIPVSQVNPR;NSVFQQGMK;QGAIVAVTGDGVNDSPALK;TGTLTQNR;VIMVTGDHPITAK 9 11.6 0.7155 0.13955 0 0 0 0 0 0 0 0 0 4.62246 0 0 P13639 EF2_HUMAN Elongation factor 2 (EF-2) (EC 3.6.5.-) EEF2 EF2 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; positive regulation of translation [GO:0045727]; translational elongation [GO:0006414] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; secretory granule lumen [GO:0034774]; synapse [GO:0045202] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] AGIIASAR;AIMDKKANIR;AYLPVNESFGFTADLR;EGIPALDNFLDK;EGIPALDNFLDKL;FSVSPVVR;GEGQLGPAER;GGGQIIPTAR;GHVFEESQVAGTPMFVVK;GPLMMYISK;IKPVLMMNK;IMGPNYTPGK;MVPTSDK;NPADLPK;STLTDSLVCK;TILMMGR;VAVEAKNPADLPK;VFSGLVSTGLK;VNFTVDQIR;VTDGALVVVDCVSGVCVQTETVLRQAIAER;YEWDVAEAR;YFDPANGK;YLAEKYEWDVAEAR 23 26.8 0 33.599 14.8274 14.7733 14.9111 12.8453 11.7431 10.6769 14.8532 14.9271 15.0664 14.7246 14.4531 14.2264 P13640 MT1G_HUMAN Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG) MT1G MT1K MT1M Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCAAGVSCTCASSCK;DPNCSCAAGVSCTCASSCKCK;KSCCSCCPVGCAK;SCCSCCPVGCAKCAQGCICK 4 68.9 0.71359 0.14847 4.78806 0 0 0 6.82439 7.07671 5.8089 0 0 0 0 3.70166 P13645 K1C10_HUMAN "Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)" KRT10 KPP Homo sapiens (Human) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]; protein heterotetramerization [GO:0051290] cell surface [GO:0009986]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] protein heterodimerization activity [GO:0046982]; structural constituent of skin epidermis [GO:0030280] ALEESNYELEGK;DAEAWFNEK;ELTTEIDNNIEQISSYK;EWYEKHGNSHQGEPR;GSLGGGFSSGGFSGGSFSR;LAADDFR;LASYLDK;LASYLDKVR;LENEIQTYR;NVQALEIELQSQLALK;NVSTGDVNVEMNAAPGVDLTQLLNNMR;QSVEADINGLR;SQYEQLAEQNR;SQYEQLAEQNRK;VLDELTLTK;VTMQNLNDR;YENEVALR 17 32.4 0 53.806 13.8221 13.9015 12.792 13.2419 11.9475 12.4341 12.5767 11.9782 13.9957 12.1034 14.0749 11.8845 P13646 K1C13_HUMAN "Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13)" KRT13 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of translation in response to stress [GO:0043555] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural molecule activity [GO:0005198] ALEEANADLEVK;LAADDFR;LAADDFRLKYENELALR;LEQEIATYR;QSVEADINGLR;TEITELR;TLQGLEIELQSQLSMK 7 15.7 0.937 -0.5569 0 0 0 0 0 0 0 0 0 10.6211 0 0 P13647 K2C5_HUMAN "Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)" KRT5 Homo sapiens (Human) epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; intermediate filament polymerization [GO:0045107]; keratinization [GO:0031424]; regulation of cell migration [GO:0030334]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] AQYEEIANR;FASFIDK;FASFIDKVR;FLEQQNK;LAELEEALQK;NLDLDSIIAEVK;TEAESWYQTK;TTAENEFVMLK 8 11.5 0.96365 -1.1083 12.4236 0 11.6537 0 10.7519 11.4547 0 8.55812 0 10.1505 0 11.6114 P13667 PDIA4_HUMAN Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) PDIA4 ERP70 ERP72 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; melanosome [GO:0042470] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723] AATQFWR;DLEHLSK;EFVTAFK;FDVSGYPTLK;IDATSASVLASR;LAPEYEK;MDATANDVPSDR;QFAPEYEK;QLEPVYNSLAK;QVQEFLK;SPPIPLAK;TQEEIVAK;VDATAETDLAK;VEGFPTIYFAPSGDKK;VSQGQLVVMQPEK 15 22.3 0 12.296 13.0204 14.5067 13.2219 0 10.4014 9.65548 10.7517 0 12.1641 12.9872 13.2539 12.1693 P13671 CO6_HUMAN Complement component C6 C6 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] ALNHLPLEYNSALYSR;ESCGYDTCYDWEK;LECNGENDCGDNSDER;LECNGENDCGDNSDERDCGR;LECNGENDCGDNSDERDCGRTK;YYQENFCEQICSK 6 6.9 0.8477 -0.062405 0 0 0 9.39665 8.05175 0 7.29214 0 7.82394 5.83421 0 0 P13682 ZNF35_HUMAN Zinc finger protein 35 (Zinc finger protein HF.10) ZNF35 Homo sapiens (Human) cellular response to retinoic acid [GO:0071300]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" YSLNSGAVK 1 1.7 0.91043 -0.28734 0 0 0 0 0 0 0 0 0 0 11.7813 0 P13688 CEAM1_HUMAN Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) CEACAM1 BGP BGP1 Homo sapiens (Human) "angiogenesis [GO:0001525]; bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of immune system process [GO:0002682]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of sprouting angiogenesis [GO:1903670]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle membrane [GO:0030658] actin binding [GO:0003779]; bile acid transmembrane transporter activity [GO:0015125]; calmodulin binding [GO:0005516]; filamin binding [GO:0031005]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782] LSQGNTTLSINPVK;TTVTGDK 2 4 0.91549 -0.39633 9.54137 0 0 0 0 0 0 12.7332 0 0 0 0 P13693 TCTP_HUMAN Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) TPT1 Homo sapiens (Human) calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; spindle pole [GO:0000922] calcium ion binding [GO:0005509]; RNA binding [GO:0003723] IREIADGLCLEVEGKMVSR;VKPFMTGAAEQIK 2 18.6 0.9594 -1.0458 12.1833 0 0 0 0 0 14.8122 0 0 0 0 0 P13716 HEM2_HUMAN Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) ALAD Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cellular response to lead ion [GO:0071284]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; negative regulation of proteasomal protein catabolic process [GO:1901799]; protein homooligomerization [GO:0051260]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to activity [GO:0014823]; response to aluminum ion [GO:0010044]; response to amino acid [GO:0043200]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to cobalt ion [GO:0032025]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to iron ion [GO:0010039]; response to lipopolysaccharide [GO:0032496]; response to mercury ion [GO:0046689]; response to methylmercury [GO:0051597]; response to oxidative stress [GO:0006979]; response to platinum ion [GO:0070541]; response to selenium ion [GO:0010269]; response to vitamin B1 [GO:0010266]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] catalytic activity [GO:0003824]; identical protein binding [GO:0042802]; porphobilinogen synthase activity [GO:0004655]; proteasome core complex binding [GO:1904854]; zinc ion binding [GO:0008270] QPQSVLHSGYFHPLLR 1 4.8 0.8937 -0.22025 0 0 0 0 0 0 0 0 9.37799 0 0 0 P13725 ONCM_HUMAN Oncostatin-M (OSM) OSM Homo sapiens (Human) immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hormone secretion [GO:0046888]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of hematopoietic stem cell differentiation [GO:1902036] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; oncostatin-M receptor binding [GO:0005147] LEGCRFLHGYHR;LLDPYIRIQGLDVPK 2 10.7 0.95481 -0.88462 0 0 0 0 0 0 0 0 0 4.17544 9.45033 0 P13726 TF_HUMAN Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142) F3 Homo sapiens (Human) activation of blood coagulation via clotting cascade [GO:0002543]; activation of plasma proteins involved in acute inflammatory response [GO:0002541]; blood coagulation [GO:0007596]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of TOR signaling [GO:0032008]; protein processing [GO:0016485] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286] cytokine receptor activity [GO:0004896]; phospholipid binding [GO:0005543]; protease binding [GO:0002020] GENYCFSVQAVIPSRTVNR;SSSSGKK;TLVRRNNTFLSLR 3 13.2 0.96688 -1.2935 0 0 0 0 0 8.99503 0 0 7.06727 5.08857 5.08712 0 P13727 PRG2_HUMAN Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)] PRG2 MBP Homo sapiens (Human) defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; transport vesicle [GO:0030133] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201] KLPLLLALLFGAVSALHLR;SLQTFSQAWFTCR 2 14.4 0.26617 0.26275 0 0 8.34301 0 0 6.32835 0 0 0 7.05918 0 7.38793 P13747 HLAE_HUMAN "HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]" HLA-E HLA-6.2 HLAE Homo sapiens (Human) "adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; natural killer cell tolerance induction [GO:0002519]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of antibody-dependent cellular cytotoxicity [GO:0001815]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immunity [GO:0002717]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of natural killer cell mediated immunity [GO:0002715]" cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] beta-2-microglobulin binding [GO:0030881]; MHC class I protein binding [GO:0042288]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608] DYLTLNEDLR;WAAVVVPSGEEQR 2 6.4 0.75895 0.071385 0 0 7.9404 0 0 0 0 0 0 0 0 0 P13765 DOB_HUMAN "HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)" HLA-DOB Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] AQKGYVRTQMSGNEVSR 1 6.2 0.85579 -0.080618 0 0 0 0 0 8.43779 0 0 0 0 0 0 P13796 PLSL_HUMAN Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) LCP1 PLS2 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; animal organ regeneration [GO:0031100]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; extracellular matrix disassembly [GO:0022617]; positive regulation of podosome assembly [GO:0071803]; protein kinase A signaling [GO:0010737]; regulation of intracellular protein transport [GO:0033157]; T cell activation involved in immune response [GO:0002286] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; integrin binding [GO:0005178] ISFDEFIK;LSPEELLLR;MINLSVPDTIDER;QFVTATDVVR;TLTLALIWQLMRR;VYALPEDLVEVNPK;YAISMAR 7 11.8 0.94602 -0.6529 11.9564 10.2138 10.8283 0 0 0 7.63858 0 0 0 8.69603 0 P13797 PLST_HUMAN Plastin-3 (T-fimbrin) (T-plastin) PLS3 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; bone development [GO:0060348] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] EANMPLPGYK;IDINMSGFNETDDLKR;ISFDEFVYIFQEVK;LIDFSNSVK;LSPEELLLR;MINLSVPDTIDER;NEALAALLR;QFVTPADVVSGNPK;RAESMLQQADK;SGNLTEDDKHNNAK;VYALPEDLVEVKPK;YAVSMAR 12 22.5 0 6.6755 10.6997 9.64872 10.8578 0 0 7.93764 13.0771 13.0416 11.7141 11.9314 11.6076 0 P13798 ACPH_HUMAN Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) APEH D3F15S2 D3S48E DNF15S2 Homo sapiens (Human) amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252] AESFFQTK 1 1.1 0.92355 -0.44817 9.80698 0 0 0 0 0 0 0 0 0 0 0 P13804 ETFA_HUMAN "Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)" ETFA Homo sapiens (Human) amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491] DPEAPIFQVADYGIVADLFK;GLLPEELTPLILATQK;LEVAPISDIIAIK;VLVAQHDVYK;VVPEMTEILK 5 20.7 0.91736 -0.35439 8.81288 8.75452 9.04854 7.75295 0 0 12.5066 9.57141 9.67326 7.0691 0 0 P13805 TNNT1_HUMAN "Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT)" TNNT1 TNT Homo sapiens (Human) negative regulation of muscle contraction [GO:0045932]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; slow-twitch skeletal muscle fiber contraction [GO:0031444]; transition between fast and slow fiber [GO:0014883] cytosol [GO:0005829]; troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014] EKAQELSDWIHQLESEK;YEINVLYNR 2 9.4 0.93277 -0.50153 0 0 0 6.28198 0 0 0 0 0 8.50712 0 0 P13807 GYS1_HUMAN "Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)" GYS1 GYS Homo sapiens (Human) glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020] "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; D-glucose binding [GO:0005536]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" AIFATQR;IGLFNSSADR;TNNFNVETLK 3 3.7 0.95175 -0.71357 0 10.5932 10.601 0 0 0 0 12.1652 0 10.6342 0 10.45 P13861 KAP2_HUMAN cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A PKR2 PRKAR2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; intracellular signal transduction [GO:0035556]; negative regulation of cAMP/PKA signal transduction [GO:0141162] cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleotide-activated protein kinase complex [GO:0031588]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991] cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625] APASVLPAATPR;IVDVIGEKIYKDGER 2 6.7 0.0046404 1.3394 0 0 0 0 0 0 10.2123 0 0 0 0 0 P13929 ENOB_HUMAN Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) ENO3 Homo sapiens (Human) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] AAVPSGASTGIYEALELR;LAQSNGWGVMVSHR;SGETEDTFIADLVVGLCTGQIK 3 12.4 0.86926 -0.096663 0 0 0 0 0 0 0 0 0 0 0 11.6387 P13942 COBA2_HUMAN Collagen alpha-2(XI) chain COL11A2 Homo sapiens (Human) cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; soft palate development [GO:0060023] collagen trimer [GO:0005581]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] AKGICPADVAYR;ELECEGGQR;FGSGGGDK;GARGLSGK;GDDGEIGPR;GDRGEVGVPGSRGEDGPEGPK;GPTGDDGPK 7 4.4 0.97287 -2.6202 0 0 6.07403 12.6532 0 0 9.60093 0 0 8.01887 9.06864 0 P13945 ADRB3_HUMAN Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor) ADRB3 ADRB3R B3AR Homo sapiens (Human) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; diet induced thermogenesis [GO:0002024]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; generation of precursor metabolites and energy [GO:0006091]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of MAPK cascade [GO:0043410]; response to cold [GO:0009409]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] beta-3 adrenergic receptor binding [GO:0031699]; beta-adrenergic receptor activity [GO:0004939]; beta3-adrenergic receptor activity [GO:0015052]; epinephrine binding [GO:0051379]; norepinephrine binding [GO:0051380]; protein homodimerization activity [GO:0042803] SPDFRSAFRR 1 2.5 0.76471 0.06162 0 0 0 0 9.57054 9.36569 0 0 0 0 0 0 P13984 T2FB_HUMAN General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) GTF2F2 RAP30 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIF complex [GO:0005674] DNA binding [GO:0003677]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ADKQHVLDMLFSAFEK;EIGVQNVK 2 9.6 0.95457 -0.82154 0 9.88753 0 0 7.0456 0 0 0 0 0 0 0 P13985 HRES1_HUMAN Putative HTLV-1-related endogenous sequence (p25) HRES1 Homo sapiens (Human) ASYRRFR;HRHPQDPR;HRRPPRPDPR 3 11.2 0.9758 -4.42 0 7.50486 0 11.1372 10.8803 10.6152 0 0 0 0 0 0 P13994 YJU2B_HUMAN Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) YJU2B CCDC130 SB115 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; response to virus [GO:0009615]; RNA splicing [GO:0008380]" post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684] SWFPSAPGSASSSKVSGVLK 1 5.1 0.9438 -0.62842 0 0 0 0 0 0 0 0 0 9.51991 0 0 P13995 MTDC_HUMAN "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" MTHFD2 NMDMC Homo sapiens (Human) folic acid metabolic process [GO:0046655]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] magnesium ion binding [GO:0000287]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; phosphate ion binding [GO:0042301] LVGDVDFEGVR;NVVVAGRSK;RTGIPTLGKNVVVAGR;VLRLEER 4 10.3 0.95363 -0.92436 0 10.4861 0 0 0 0 0 0 2.12559 0 7.29205 0 P14091 CATE_HUMAN Cathepsin E (EC 3.4.23.34) [Cleaved into: Cathepsin E form I; Cathepsin E form II] CTSE Homo sapiens (Human) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231] aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233] KTLLLLLLVLLELGEAQGSLHR;TLLLLLLVLLELGEAQGSLHRVPLRR;VGLAPAVP;VPLRRHPSLK 4 10.1 0.034799 0.56047 15.9854 14.9308 12.1873 13.4488 13.8099 13.7603 14.9899 14.9352 15.068 14.3712 14.3796 12.9376 P14136 GFAP_HUMAN Glial fibrillary acidic protein (GFAP) GFAP Homo sapiens (Human) astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; D-aspartate import across plasma membrane [GO:0070779]; extracellular matrix organization [GO:0030198]; gene expression [GO:0010467]; intermediate filament organization [GO:0045109]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron projection development [GO:0010977]; neuron projection regeneration [GO:0031102]; positive regulation of Schwann cell proliferation [GO:0010625]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of neurotransmitter uptake [GO:0051580]; regulation of protein-containing complex assembly [GO:0043254]; Schwann cell proliferation [GO:0014010] astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111] identical protein binding [GO:0042802]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; structural constituent of cytoskeleton [GO:0005200] ALAAELNQLRAK;FLEQQNK;GTNESLER;LDQLTANSARLEVER 4 9.7 0.97191 -1.3531 0 0 0 0 10.333 11.4813 0 0 0 0 0 0 P14138 EDN3_HUMAN Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) EDN3 Homo sapiens (Human) axon extension [GO:0048675]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; melanocyte differentiation [GO:0030318]; neural crest cell migration [GO:0001755]; neutrophil chemotaxis [GO:0030593]; peptide hormone secretion [GO:0030072]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of smooth muscle contraction [GO:0045987]; potassium ion transmembrane transport [GO:0071805]; regulation of developmental pigmentation [GO:0048070]; regulation of gene expression [GO:0010468]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; signal transduction [GO:0007165]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826] extracellular region [GO:0005576]; extracellular space [GO:0005615] endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] DQQSKQALDLHHPK;TDKEEEGKVEVK 2 10.9 0.98088 -1.6258 0 9.28593 0 0 7.94433 0 0 0 0 0 0 0 P14151 LYAM1_HUMAN L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L) SELL LNHR LYAM1 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; response to cytokine [GO:0034097] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; oligosaccharide binding [GO:0070492]; protease binding [GO:0002020]; sialic acid binding [GO:0033691] RFCRDNYTDLVAIQNK;SFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLAR;WNDDACHK 3 15.9 0.95365 -0.8918 0 9.09859 8.34762 0 6.17213 0 0 0 0 0 0 0 P14174 MIF_HUMAN Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF GLIF MMIF Homo sapiens (Human) "carboxylic acid metabolic process [GO:0019752]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of protein metabolic process [GO:0051248]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of tumor necrosis factor production [GO:0032760]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; identical protein binding [GO:0042802]; phenylpyruvate tautomerase activity [GO:0050178]; protease binding [GO:0002020] IGGAQNR;PMFIVNTNVPR 2 15.7 0.004878 1.5949 8.5315 12.2448 12.2004 7.95361 8.28813 9.36413 9.41766 0 0 0 0 9.20636 P14207 FOLR2_HUMAN "Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)" FOLR2 Homo sapiens (Human) cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; inflammatory response [GO:0006954]; positive regulation of cell population proliferation [GO:0008284]; sperm-egg recognition [GO:0035036] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023] FLDVPLCK;TKPGPEDK;WWEDCHTSHTCK 3 11 0.9528 -0.75277 0 8.01279 0 0 0 0 0 4.37518 0 0 0 11.1972 P14209 CD99_HUMAN CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99) CD99 MIC2 MIC2X MIC2Y Homo sapiens (Human) homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] NANAEPAVQR 1 5.4 0.0047962 1.536 0 0 0 0 0 0 0 0 0 10.4314 10.0466 0 P14210 HGF_HUMAN Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] HGF HPTA Homo sapiens (Human) cell chemotaxis [GO:0060326]; cell morphogenesis [GO:0000902]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of p38MAPK cascade [GO:1900744]; skeletal muscle cell proliferation [GO:0014856] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] ESWVLTAR;KEFGHEFDLYENK;MVLGVIVPGRGCAIPNRPGIFVR;QCLWFPFNSMSSGVK;WDSQYPHEHDMTPENFK 5 10.4 0.88162 -0.16801 7.96388 0 0 0 0 10.4171 0 0 0 0 6.79377 0 P14210 HGF_HUMAN Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] HGF HPTA Homo sapiens (Human) cell chemotaxis [GO:0060326]; cell morphogenesis [GO:0000902]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; mitotic cell cycle [GO:0000278]; myoblast proliferation [GO:0051450]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of p38MAPK cascade [GO:1900744]; skeletal muscle cell proliferation [GO:0014856] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] KEFGHEFDLYENK;NMRDITWALN;QCLWFPFNSMSSGVK 3 12.8 0.9779 -1.5044 0 0 0 0 0 0 0 10.2263 0 0 0 0 P14314 GLU2B_HUMAN Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) PRKCSH G19P1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; N-glycan processing [GO:0006491] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; glucosidase II complex [GO:0017177]; intracellular membrane-bounded organelle [GO:0043231] calcium ion binding [GO:0005509]; phosphoprotein binding [GO:0051219]; protein kinase C binding [GO:0005080]; transmembrane transporter binding [GO:0044325] ESLQQMAEVTR;ETMVTSTTEPSR;LWEEQLAAAK;MPPYDEQTQAFIDAAQEAR;NKFEEAER;SLEDQVEMLR;TVKEEAEKPER;TVKEEAEKPEREAK 8 15.9 0 3.4547 0 7.35253 12.4147 9.23218 9.60857 0 12.4696 10.8732 10.6101 12.231 11.3415 0 P14317 HCLS1_HUMAN Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) HCLS1 HS1 Homo sapiens (Human) actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear transport [GO:0051169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] GEVEKHTSQKDYSR;HESQRDYAK;TEHINIHQLRNK 3 7.2 0.97518 -3.9909 0 0 0 0 0 0 0 0 9.03006 0 0 0 P14317 HCLS1_HUMAN Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) HCLS1 HS1 Homo sapiens (Human) actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear transport [GO:0051169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] ALVASMESRRTEWIR;RNTSPREIMPR;TEHINIHQLRNK 3 18.2 0.74525 0.099933 0 0 0 0 0 0 9.81131 0 0 0 0 9.94869 P14324 FPPS_HUMAN "Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)" FDPS FPS KIAA1293 Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777] dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] SVGVFLLPAPYWAPRER 1 4.1 0.92117 -0.44173 0 0 0 3.27696 0 0 0 0 10.2612 4.64339 0 0 P14373 TRI27_HUMAN Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) TRIM27 RFP RNF76 Homo sapiens (Human) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of autophagy [GO:0010507]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type II interferon production [GO:0032729]; protein K63-linked ubiquitination [GO:0070534]; protein sumoylation [GO:0016925]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; suppression of viral release by host [GO:0044790]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GHSVLPLEEAVEGFK 1 2.9 0.84918 -0.07642 0 0 12.962 0 0 0 0 0 0 0 0 0 P14384 CBPM_HUMAN Carboxypeptidase M (CPM) (EC 3.4.17.12) CPM Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] EHRIGIPEFK;IGIPEFKYVANMHGDETVGR;YPREEKLPSFWNNNK 3 8.6 0.97236 -2.7575 0 0 0 10.4446 0 0 0 0 0 10.8883 8.86329 0 P14406 CX7A2_HUMAN "Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)" COX7A2 COX7AL Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803]; respiratory chain complex IV [GO:0045277] oxidoreductase activity [GO:0016491] TISTASR 1 8.4 0.93437 -0.51575 0 0 0 0 0 0 0 0 0 0 0 9.37582 P14410 SUIS_HUMAN "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Homo sapiens (Human) polysaccharide digestion [GO:0044245]; sucrose catabolic process [GO:0005987] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]" CTQRGCVWR;FSGLEISLIVLFVIVTIIAIALIVVLATK;TGSSLSK;WMQLGAFYPYSRNHNIANTR 4 3.6 0.94446 -0.63051 0 0 0 0 8.61703 0 0 0 0 0 9.89574 0 P14415 AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2) ATP1B2 Homo sapiens (Human) cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-substrate adhesion [GO:0031589]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; lateral ventricle development [GO:0021670]; membrane repolarization [GO:0086009]; motor behavior [GO:0061744]; negative regulation of glial cell migration [GO:1903976]; neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration [GO:0021944]; photoreceptor cell maintenance [GO:0045494]; plasma membrane bounded cell projection organization [GO:0120036]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein stabilization [GO:0050821]; retina homeostasis [GO:0001895]; sodium ion export across plasma membrane [GO:0036376]; third ventricle development [GO:0021678]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; astrocyte projection [GO:0097449]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674] FLEPYNDSIQAQK;INAANIATDDER 2 8.6 0.9544 -0.91332 0 0 0 0 0 0 0 0 11.0561 0 0 0 P14543 NID1_HUMAN Nidogen-1 (NID-1) (Entactin) NID1 NID Homo sapiens (Human) basement membrane organization [GO:0071711]; canonical Wnt signaling pathway [GO:0060070]; cell-matrix adhesion [GO:0007160]; glomerular basement membrane development [GO:0032836]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; proteoglycan binding [GO:0043394]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] NGFSITGGEFTR 1 1 0.78342 0.020022 0 0 6.74214 0 0 0 0 0 0 0 0 0 P14550 AK1A1_HUMAN Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) AKR1A1 ALDR1 ALR Homo sapiens (Human) aldehyde catabolic process [GO:0046185]; cellular detoxification of aldehyde [GO:0110095]; D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid biosynthetic process [GO:0019853]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; synapse [GO:0045202] aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; glucuronolactone reductase activity [GO:0047941]; glycerol dehydrogenase (NADP+) activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; methylglyoxal reductase (NADPH) (acetol producing) activity [GO:1990002]; S-nitrosoglutathione reductase (NADH) activity [GO:0080007]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163] KVICIPKSITPSR;MPLIGLGTWK;SPAQILLR 3 9.5 0 5.3309 0 0 0 7.72178 0 7.12412 12.4538 12.1407 12.2995 0 9.27209 11.8788 P14555 PA2GA_HUMAN "Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)" PLA2G2A PLA2B PLA2L RASF-A Homo sapiens (Human) arachidonate secretion [GO:0050482]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; intestinal stem cell homeostasis [GO:0036335]; killing of cells of another organism [GO:0031640]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; regulation of neutrophil activation [GO:1902563] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543] CCVTHDCCYK;DATDRCCVTHDCCYKR;LEKRGCGTK 3 17.4 0.77821 0.040528 0 0 0 0 0 6.54302 8.12985 0 0 0 0 6.64024 P14598 NCF1_HUMAN Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) NCF1 NOXO2 SH3PXD1A Homo sapiens (Human) cellular defense response [GO:0006968]; cellular response to glucose stimulus [GO:0071333]; cellular response to testosterone stimulus [GO:0071394]; innate immune response [GO:0045087]; protein targeting to membrane [GO:0006612]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of respiratory burst involved in inflammatory response [GO:0060264]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886] "electron transfer activity [GO:0009055]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; SH3 domain binding [GO:0017124]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]" NSVRFLQQRR 1 2.6 0.76536 0.060302 0 0 0 0 0 0 0 0 12.0506 0 0 0 P14616 INSRR_HUMAN Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] INSRR IRR Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to alkaline pH [GO:0071469]; male sex determination [GO:0030238]; protein autophosphorylation [GO:0046777] axon [GO:0030424]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GLRLPTSNNDPR;LEEVTGTR;TVNELASPRECIEFLK;VAWEASSK;WKPPTQRNGNLTYYLVLWQR;YRRLGEEATVLCVSR 6 6.1 0.97491 -3.1661 10.1699 0 0 9.69523 0 0 0 11.378 0 9.30214 0 0 P14618 KPYM_HUMAN Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; programmed cell death [GO:0012501] cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; histone H2AXY142 kinase activity [GO:0140801]; histone H3T11 kinase activity [GO:0035402]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; pyruvate kinase activity [GO:0004743]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] APIIAVTR;ASDVHEVR;ASDVHEVRK;DPVQEAWAEDVDLR;EAEAAIYHLQLFEELRR;FDEILEASDGIMVAR;FGVEQDVDMVFASFIRK;GADFLVTEVENGGSLGSK;GDLGIEIPAEK;GDLGIEIPAEKVFLAQK;GDYPLEAVR;GDYPLEAVRMQHLIAR;GSGTAEVELK;GSGTAEVELKK;GVNLPGAAVDLPAVSEK;GVNLPGAAVDLPAVSEKDIQDLK;IENHEGVR;ITLDNAYMEK;IYVDDGLISLQVK;KGVNLPGAAVDLPAVSEK;KGVNLPGAAVDLPAVSEKDIQDLK;LAPITSDPTEATAVGAVEASFK;LDIDSPPITAR;MQHLIAR;NTGIICTIGPASR;RFDEILEASDGIMVAR;SAHQVAR;SGMNVAR;SVETLKEMIK;TATESFASDPILYRPVAVALDTK;TATESFASDPILYRPVAVALDTKGPEIR;VNFAMNVGK;VVEVGSK 33 58.8 0 273.47 14.8544 14.5862 13.7905 11.6888 11.909 12.5378 17.2667 17.2291 17.3497 16.3262 15.8239 15.4048 P14625 ENPL_HUMAN Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) HSP90B1 GRP94 HSPC4 TRA1 Homo sapiens (Human) "actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; cellular response to manganese ion [GO:0071287]; ERAD pathway [GO:0036503]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]" collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; sperm plasma membrane [GO:0097524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] DISTNYYASQK;EAESSPFVER;EEEAIQLDGLNASQIR;ELISNASDALDK;ELISNASDALDKIR;ESTAEKDEL;EVEEDEYK;EVEEDEYKAFYK;FAFQAEVNR;GLFDEYGSK;GVVDSDDLPLNVSR;IYFMAGSSR;LGVIEDHSNR;LIINSLYK;LISLTDENALSGNEELTVK;LSLNIDPDAK;SEKFAFQAEVNRMMK;SGTSEFLNK;SGYLLPDTK;SILFVPTSAPR;TDDEVVQR;TDDEVVQREEEAIQLDGLNASQIR;TFEINPR;TRLAKLLR;YSQFINFPIYVWSSK 25 29 0 95.245 15.5504 15.3362 14.7285 12.6319 13.2409 12.6708 14.1335 14.1741 14.3574 14.4628 14.6312 14.1947 P14635 CCNB1_HUMAN G2/mitotic-specific cyclin-B1 CCNB1 CCNB Homo sapiens (Human) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] centrosome [GO:0005813]; cyclin B1-CDK1 complex [GO:0097125]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; patched binding [GO:0005113]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389] ILRALNFGLGRPLPLHFLRR;INMAGAKRVPTAPAATSKPGLRPR 2 10.2 0.74584 0.093895 0 0 0 0 0 0 0 0 6.99232 0 0 5.83867 P14649 MYL6B_HUMAN Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) MYL6B MLC1SA Homo sapiens (Human) muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461] calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; structural constituent of muscle [GO:0008307] ALGQNPTNAEVLK;DQLEEFKEAFELFDR;ILYSQCGDVMR 3 18.8 0.95011 -0.66543 0 0 0 0 0 11.6232 0 0 0 0 10.7507 0 P14652 HXB2_HUMAN Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8) HOXB2 HOX2H Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; morphogenesis of an epithelial sheet [GO:0002011]; nervous system development [GO:0007399]; neural nucleus development [GO:0048857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 3 development [GO:0021569]; rhombomere 4 development [GO:0021570] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" RLRTAYTNTQLLELEK 1 4.5 0.96419 -1.1157 0 0 0 0 0 0 11.5923 0 0 0 0 0 P14653 HXB1_HUMAN Homeobox protein Hox-B1 (Homeobox protein Hox-2I) HOXB1 HOX2I Homo sapiens (Human) anatomical structure formation involved in morphogenesis [GO:0048646]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; facial nucleus development [GO:0021754]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 4 development [GO:0021570]; rhombomere 5 development [GO:0021571] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" VEIAATLELNETQVKIWFQNR;VPPAPPGCPK 2 10.3 0.94653 -0.66144 0 0 0 0 9.12939 0 0 11.1551 0 0 0 0 P14678 RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') SNRPB COD SNRPB1 Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone pre-mRNA 3'end processing complex [GO:0071204]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U2 snRNP binding [GO:1990447] HMNLILCDCDEFRK 1 5.8 0.64063 0.17225 7.1819 0 0 0 0 0 0 0 0 0 0 0 P14679 TYRO_HUMAN Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) TYR Homo sapiens (Human) cell population proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; pigmentation [GO:0043473]; response to blue light [GO:0009637]; response to cAMP [GO:0051591]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; thymus development [GO:0048538]; visual perception [GO:0007601] cytoplasm [GO:0005737]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; perinuclear region of cytoplasm [GO:0048471] copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503] ECCPPWSGDR;SYLEQASR;TCQCSGNFMGFNCGNCK 3 6.6 0.94534 -0.64248 0 0 4.91629 0 0 0 0 0 0 0 0 0 P14735 IDE_HUMAN Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) IDE Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; bradykinin catabolic process [GO:0010815]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor signaling pathway [GO:0008286]; peptide catabolic process [GO:0043171]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of aerobic respiration [GO:1903715]; ubiquitin recycling [GO:0010992] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] ATP binding [GO:0005524]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] FAQFFLCPLFDESCK;IIEKMATFEIDEK;LFQLEKATGNPK;QDDKFFLPK;QPILLKKIIEK;SIEDMTEEAFQK;VEAFLITMEK 7 7.7 0.97495 -3.702 11.5816 0 0 11.0406 9.00475 0 8.49197 10.6493 0 0 0 0 P14778 IL1R1_HUMAN "Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]" IL1R1 IL1R IL1RA IL1RT1 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; positive regulation of interleukin-1-mediated signaling pathway [GO:2000661]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of inflammatory response [GO:0050727]; response to interleukin-1 [GO:0070555] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] "interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; transmembrane signaling receptor activity [GO:0004888]" IDIVLWYRDSCYDFLPIK;LWFVPAK;RSTLITVLNISEIESR;YHMPVQRRSPSSK 4 9.5 0.96643 -1.2741 0 0 0 8.05077 6.54384 0 10.2623 0 0 0 10.2969 0 P14780 MMP9_HUMAN Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] MMP9 CLG4B Homo sapiens (Human) apoptotic process [GO:0006915]; cell migration [GO:0016477]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cation channel activity [GO:2001258]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of epithelial cell differentiation involved in kidney development [GO:2000697]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor binding [GO:1900122]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724] collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] QRQSTLVLFPGDLR 1 2 0.92209 -0.44318 0 0 0 0 0 0 8.94503 0 0 0 0 0 P14854 CX6B1_HUMAN Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) COX6B1 COX6B Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; substantia nigra development [GO:0021762]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129] AEGTFPGKI 1 10.5 0.89763 -0.23964 0 10.374 0 0 0 0 0 0 0 0 0 0 P14866 HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (hnRNP L) HNRNPL HNRPL P/OKcl.14 Homo sapiens (Human) "mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976] FSTPEQAAK;NPNGPYPYTLK;SSSGLLEWESK;TPASPVVHIR;YYGGGSEGGR 5 8.7 0 3.3261 0 8.8157 9.80494 6.8835 7.99966 0 0 0 0 12.7879 12.6186 0 P14868 SYDC_HUMAN "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)" DARS1 DARS PIG40 Homo sapiens (Human) aspartyl-tRNA aminoacylation [GO:0006422]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] aminoacylase activity [GO:0004046]; aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; RNA binding [GO:0003723] ATVNQDTR;EIMDAAEDYAK;FAANINK;GEEILSGAQR;GFVEIQTPK;QSNSYDMFMRGEEILSGAQR;VFSIGPVFR 7 12.8 0.88054 -0.16839 0 12.007 11.9677 0 0 4.75499 0 10.7979 4.1112 12.0707 11.974 0 P14902 I23O1_HUMAN "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)" IDO1 IDO INDO Homo sapiens (Human) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; kynurenic acid biosynthetic process [GO:0034276]; multicellular organismal response to stress [GO:0033555]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of chronic inflammatory response [GO:0002678]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of type 2 immune response [GO:0002830]; quinolinate biosynthetic process [GO:0019805]; response to lipopolysaccharide [GO:0032496]; swimming behavior [GO:0036269]; T cell proliferation [GO:0042098]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441] cytoplasm [GO:0005737]; cytosol [GO:0005829]; smooth muscle contractile fiber [GO:0030485]; stereocilium bundle [GO:0032421] "electron transfer activity [GO:0009055]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]" HLPDLIESGQLR;NIAVPYCQLSKK 2 6 0.88827 -0.20214 0 0 0 0 0 0 0 0 11.2868 0 10.0996 0 P14920 OXDA_HUMAN D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO DAMOX Homo sapiens (Human) D-alanine catabolic process [GO:0055130]; D-amino acid catabolic process [GO:0019478]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; digestion [GO:0007586]; dopamine biosynthetic process [GO:0042416]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; proline catabolic process [GO:0006562] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; peroxisomal matrix [GO:0005782]; presynaptic active zone [GO:0048786] D-amino-acid oxidase activity [GO:0003884]; FAD binding [GO:0071949]; glycine oxidase activity [GO:0043799]; identical protein binding [GO:0042802] GQIMKVDAPWMKHFILTHDPER 1 6.3 0.55104 0.18344 0 0 0 0 0 9.70612 0 0 0 0 0 0 P14921 ETS1_HUMAN Protein C-ets-1 (p54) ETS1 EWSR2 Homo sapiens (Human) cell motility [GO:0048870]; immune response [GO:0006955]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to antibiotic [GO:0046677]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear receptor coactivator activity [GO:0030374]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]" GVDFQKFCMNGAALCALGK;QGPSNTYEDPR 2 6.2 0.91525 -0.3454 0 0 0 5.88789 0 0 0 0 0 12.1983 12.209 0 P14923 PLAK_HUMAN Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) JUP CTNNG DP3 Homo sapiens (Human) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; desmosome assembly [GO:0002159]; detection of mechanical stimulus [GO:0050982]; endothelial cell-cell adhesion [GO:0071603]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell population proliferation [GO:0042127]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; gamma-catenin-TCF7L2 complex [GO:0071665]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; specific granule lumen [GO:0035580]; Z disc [GO:0030018]; zonula adherens [GO:0005915] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; cytoskeletal protein-membrane anchor activity [GO:0106006]; nuclear receptor binding [GO:0016922]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; structural molecule activity [GO:0005198]; transcription coactivator activity [GO:0003713] ATIGLIR;LAEPSQLLK;LLNDEDPVVVTK 3 3.8 0.013889 0.81278 10.8383 12.0973 12.0556 0 0 0 0 0 10.8255 0 0 0 P15018 LIF_HUMAN Leukemia inhibitory factor (LIF) (Differentiation-stimulating factor) (D factor) (Melanoma-derived LPL inhibitor) (MLPLI) (Emfilermin) LIF HILDA Homo sapiens (Human) blood vessel remodeling [GO:0001974]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway via STAT [GO:0097696]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; immune response [GO:0006955]; leukemia inhibitory factor signaling pathway [GO:0048861]; lung alveolus development [GO:0048286]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; macrophage differentiation [GO:0030225]; meiotic nuclear division [GO:0140013]; muscle organ morphogenesis [GO:0048644]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of hormone secretion [GO:0046888]; negative regulation of meiotic nuclear division [GO:0045835]; neuron development [GO:0048666]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; stem cell differentiation [GO:0048863]; trophoblast giant cell differentiation [GO:0060707] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; leukemia inhibitory factor receptor binding [GO:0005146]; signaling receptor binding [GO:0005102] IVVYLGTSLGNITR;LCSKYHVGHVDVTYGPDTSGKDVFQK;VLAAGVVPLLLVLHWK 3 27.7 0.77612 0.042491 0 0 10.4629 0 0 0 3.38515 0 0 0 0 11.9075 P15036 ETS2_HUMAN Protein C-ets-2 ETS2 Homo sapiens (Human) ectodermal cell fate commitment [GO:0001712]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" AVMSQALKATFSGFKK;TSGKRYVYR 2 5.3 0.97798 -1.5048 0 0 0 0 10.4753 0 0 0 13.5137 0 0 0 P15056 BRAF_HUMAN Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) "animal organ morphogenesis [GO:0009887]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to xenobiotic stimulus [GO:0071466]; endothelial cell apoptotic process [GO:0072577]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of axon regeneration [GO:0048680]; positive regulation of axonogenesis [GO:0050772]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of T cell differentiation [GO:0045580]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic vesicle exocytosis [GO:0016079]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; visual learning [GO:0008542]" cell body [GO:0044297]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110] LDALQQR 1 0.9 0.91725 -0.41819 0 0 0 0 0 0 0 0 0 0 10.105 0 P15088 CBPA3_HUMAN Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3) CPA3 Homo sapiens (Human) proteolysis [GO:0006508]; regulation of angiotensin levels in blood [GO:0002002] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] MRLILPVGLIATTLAIAPVR;RLILPVGLIATTLAIAPVRFDR;VKPQDEK 3 7.2 0.88069 -0.14986 0 0 0 0 7.77208 0 0 9.92856 0 0 0 0 P15090 FABP4_HUMAN "Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; fatty acid transport [GO:0015908]; long-chain fatty acid transport [GO:0015909]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of inflammatory response [GO:0050729]; response to bacterium [GO:0009617]; white fat cell differentiation [GO:0050872] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; nucleus [GO:0005634] fatty acid binding [GO:0005504]; hormone receptor binding [GO:0051427]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transmembrane transporter activity [GO:0005324] EDDKLVVECVMK;LVSSENFDDYMK 2 18.2 0.95336 -0.73304 8.36023 0 0 0 0 0 0 0 0 0 0 0 P15104 GLNA_HUMAN Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) GLUL GLNS Homo sapiens (Human) angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; protein palmitoylation [GO:0018345]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization to nucleolus [GO:1904749]; regulation of sprouting angiogenesis [GO:1903670]; response to glucose [GO:0009749]; ribosome biogenesis [GO:0042254] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; glutamine synthetase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] QVYMSLPQGEK;TCLLNETGDEPFQYK 2 7 0.77577 0.044654 0 0 0 0 0 0 0 0 0 6.25908 10.8217 0 P15121 ALDR_HUMAN Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) AKR1B1 ALDR1 ALR2 Homo sapiens (Human) C21-steroid hormone biosynthetic process [GO:0006700]; carbohydrate metabolic process [GO:0005975]; cellular hyperosmotic salinity response [GO:0071475]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; epithelial cell maturation [GO:0002070]; fructose biosynthetic process [GO:0046370]; L-ascorbic acid biosynthetic process [GO:0019853]; metanephric collecting duct development [GO:0072205]; negative regulation of apoptotic process [GO:0043066]; regulation of urine volume [GO:0035809]; renal water homeostasis [GO:0003091]; retinoid metabolic process [GO:0001523] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; allyl-alcohol dehydrogenase activity [GO:0047655]; electron transfer activity [GO:0009055]; glyceraldehyde oxidoreductase activity [GO:0043795]; glycerol dehydrogenase (NADP+) activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758] DYPFHEEF;EELFIVSK;LLLNNGAK;NLVVIPK;SPPGQVTEAVK;TTAQVLIR;VAIDVGYR 7 18.4 0 56.821 0 3.35783 3.60419 0 0 0 14.3746 14.1879 16.5815 15.0482 14.9052 11.7285 P15153 RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) RAC2 Homo sapiens (Human) actin filament organization [GO:0007015]; bone resorption [GO:0045453]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; erythrocyte enucleation [GO:0043131]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte aggregation [GO:0071593]; mast cell proliferation [GO:0070662]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of T cell proliferation [GO:0042129]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; NADPH oxidase complex [GO:0043020]; nuclear envelope [GO:0005635]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase regulator activity [GO:0019887] AVLCPQPTR;DDKDTIEK;LAPITYPQGLALAKEIDSVK 3 19.3 0.97824 -1.929 0 0 0 0 0 0 0 4.0917 0 10.9498 0 11.3801 P15169 CBPN_HUMAN Carboxypeptidase N catalytic chain (CPN) (EC 3.4.17.3) (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum carboxypeptidase N) (SCPN) CPN1 ACBP Homo sapiens (Human) bradykinin catabolic process [GO:0010815]; peptide metabolic process [GO:0006518]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; response to glucocorticoid [GO:0051384] extracellular region [GO:0005576]; extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] NQRIVQLIQDTR 1 2.6 0.83623 -0.029783 0 0 0 0 0 0 0 0 5.19775 0 0 0 P15170 ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) GSPT1 ERF3A Homo sapiens (Human) "G1/S transition of mitotic cell cycle [GO:0000082]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747] DMGTVVLGK;ENLSAAFSR;SVVAPPGAPK;TIAIGKVLKLVPEK 4 6.6 0.012474 0.9009 0 0 0 0 0 0 0 10.1692 0 0 10.8049 0 P15172 MYOD1_HUMAN Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3) MYOD1 BHLHC1 MYF3 MYOD Homo sapiens (Human) "cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to oxygen levels [GO:0071453]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; myoblast fate determination [GO:0007518]; myoblast fusion [GO:0007520]; myotube cell development [GO:0014904]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast proliferation [GO:2000818]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; transcription by RNA polymerase II [GO:0006366]" chromatin [GO:0000785]; euchromatin [GO:0000791]; myofibril [GO:0030016]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]" NAIRYIEGLQALLR;SNCSDGMMDYSGPPSGAR 2 10 0.93689 -0.5571 0 0 0 0 0 0 0 0 0 0 10.4749 0 P15173 MYOG_HUMAN Myogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4) MYOG BHLHC3 MYF4 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; muscle cell fate commitment [GO:0042693]; negative regulation of cell population proliferation [GO:0008285]; ossification [GO:0001503]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; striated muscle atrophy [GO:0014891] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" MELYETSPYFYQEPR 1 6.7 0.78361 0.030995 0 0 0 0 0 0 8.12655 0 0 0 0 0 P15260 INGR1_HUMAN Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) IFNGR1 Homo sapiens (Human) astrocyte activation [GO:0048143]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of gene expression [GO:0010628]; positive regulation of tumor necrosis factor production [GO:0032760]; response to virus [GO:0009615]; signal transduction [GO:0007165]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906] EKSIILPKSLISVVR 1 3.1 0.44434 0.19284 0 0 0 8.7361 8.1281 0 0 0 0 0 0 0 P15309 PPAP_HUMAN Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39] ACP3 ACPP Homo sapiens (Human) adenosine metabolic process [GO:0046085]; dephosphorylation [GO:0016311]; lipid metabolic process [GO:0006629]; nucleotide metabolic process [GO:0009117]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; purine nucleobase metabolic process [GO:0006144]; regulation of sensory perception of pain [GO:0051930]; thiamine metabolic process [GO:0006772] apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi cisterna [GO:0031985]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] "5'-nucleotidase activity [GO:0008253]; acid phosphatase activity [GO:0003993]; choline binding [GO:0033265]; histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; lysophosphatidic acid phosphatase activity [GO:0052642]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; thiamine phosphate phosphatase activity [GO:0042131]; XMP 5'-nucleosidase activity [GO:0106411]" LQGGVLVNEILNHMKR 1 4.1 0.27429 0.25587 0 0 0 0 0 0 0 0 0 0 9.69645 0 P15311 EZRI_HUMAN Ezrin (Cytovillin) (Villin-2) (p81) EZR VIL2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; astral microtubule organization [GO:0030953]; cellular response to cAMP [GO:0071320]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; intestinal D-glucose absorption [GO:0001951]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to plasma membrane [GO:1903078]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein kinase A signaling [GO:0010737]; protein localization to cell cortex [GO:0072697]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of microvillus length [GO:0032532]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; terminal web assembly [GO:1902896] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell periphery [GO:0071944]; cell projection [GO:0042995]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; vesicle [GO:0031982] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548] ALQLEEER;APDFVFYAPR;DNAMLEYLK;ELSEQIQR;ELSEQIQRALQLEEER;ENPLQFK;EVHKSGYLSSER;FVIKPIDK;IAQDLEMYGINYFEIKNKK;IDEFEAL;IGFPWSEIR;KENPLQFK;KPDTIEVQQMK;KVSAQEVR;LQDYEEK;NISFNDKK;QAVDQIK;QAVDQIKSQEQLAAELAEYTAK;QLFDQVVK;QLLTLSSELSQAR;QQLETEK;QRIDEFEAL;RKPDTIEVQQMK;RTHNDIIHNENMRQGR;SGYLSSER;SQEQLAAELAEYTAK;VSAQEVR;VTTMDAELEFAIQPNTTGK 28 37.5 0 23.07 13.5492 13.3143 13.2857 10.5285 9.77962 10.4344 14.0682 13.4665 13.477 14.7944 13.2735 13.8073 P15328 FOLR1_HUMAN "Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)" FOLR1 FOLR Homo sapiens (Human) anterior neural tube closure [GO:0061713]; axon regeneration [GO:0031103]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell adhesion [GO:0007155]; cellular response to folic acid [GO:0071231]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heart looping [GO:0001947]; neural crest cell migration involved in heart formation [GO:0003147]; pharyngeal arch artery morphogenesis [GO:0061626]; receptor-mediated endocytosis [GO:0006898]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; sperm-egg recognition [GO:0035036] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] folic acid binding [GO:0005542]; folic acid receptor activity [GO:0061714]; signaling receptor activity [GO:0038023] EDCEQWWEDCRTSYTCK;HHKEKPGPEDKLHEQCRPWR 2 14.4 0.80825 0.010644 0 0 0 4.09719 0 0 0 0 5.45891 0 4.76675 0 P15374 UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) UCHL3 Homo sapiens (Human) post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; peptidase activity [GO:0008233]; ubiquitin binding [GO:0043130] FLEESVSMSPEER;KFLEESVSMSPEER 2 6.1 0.05641 0.45828 0 0 7.5741 0 0 0 0 0 0 0 3.24215 0 P15391 CD19_HUMAN B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) CD19 Homo sapiens (Human) antigen receptor-mediated signaling pathway [GO:0050851]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell differentiation [GO:0001923]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of B cell activation [GO:0050864]; regulation of B cell receptor signaling pathway [GO:0050855] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] EATSLGSQSYEDMR 1 2.5 0.87615 -0.12652 7.84336 0 9.0227 0 0 0 0 0 0 0 0 0 P15498 VAV_HUMAN Proto-oncogene vav VAV1 VAV Homo sapiens (Human) cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; integrin-mediated signaling pathway [GO:0007229]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; reactive oxygen species metabolic process [GO:0072593]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784] ACQMLLRGTFYQGYRCHR;DDSSGDR;EVNLRPQMSQFLCLK;GQQGWWR;IMTAEGLYR;ITSVERR 6 7.5 0.98133 -1.6989 3.8055 10.1672 0 0 0 0 7.41007 9.65193 0 0 8.71401 10.6847 P15509 CSF2R_HUMAN Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116) CSF2RA CSF2R CSF2RY Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of leukocyte proliferation [GO:0070665] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023] TVAPASSLNVR 1 2.8 0.89823 -0.23511 0 0 0 0 9.19899 0 0 0 0 0 0 0 P15538 C11B1_HUMAN "Cytochrome P450 11B1, mitochondrial (CYP11B1) (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B1) (EC 1.14.15.4)" CYP11B1 S11BH Homo sapiens (Human) aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; glucose homeostasis [GO:0042593]; immune response [GO:0006955]; regulation of blood pressure [GO:0008217]; sterol metabolic process [GO:0016125] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507] LAEAEMLLLLHHVLKHLQVETLTQEDIK;MVYSFILRPSMFPLLTFR;SLSRWTSPK;TVLPFEAMPR 4 12.9 0.9775 -2.1675 0 10.3416 0 10.1854 0 5.91461 0 5.38042 11.5692 0 0 11.2683 P15559 NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) NQO1 DIA4 NMOR1 Homo sapiens (Human) "cell redox homeostasis [GO:0045454]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to metal ion [GO:0071248]; cellular response to oxidative stress [GO:0034599]; innate immune response [GO:0045087]; NADH oxidation [GO:0006116]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ferroptosis [GO:0110076]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of neuron apoptotic process [GO:0043525]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; removal of superoxide radicals [GO:0019430]; response to alkaloid [GO:0043279]; response to amine [GO:0014075]; response to carbohydrate [GO:0009743]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to flavonoid [GO:1905395]; response to hormone [GO:0009725]; response to hydrogen sulfide [GO:1904880]; response to ischemia [GO:0002931]; response to L-glutamine [GO:1904844]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to testosterone [GO:0033574]; response to tetrachloromethane [GO:1904772]; response to toxic substance [GO:0009636]; synaptic transmission, cholinergic [GO:0007271]; ubiquinone metabolic process [GO:0006743]; vitamin E metabolic process [GO:0042360]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH:ubiquinone reductase (non-electrogenic) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; RNA binding [GO:0003723]; superoxide dismutase activity [GO:0004784]" ALIVLAHSER;EAAAAALKK;EGHLSPDIVAEQK;IQILEGWK;LKDPANFQYPAESVLAYK;SIPTDNQIK;TSFNYAMK 7 27.4 0 12.29 0 0 4.94115 0 0 0 13.9348 13.1303 13.7073 14.2606 12.789 0 P15586 GNS_HUMAN N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) GNS Homo sapiens (Human) glycosaminoglycan catabolic process [GO:0006027]; keratan sulfate catabolic process [GO:0042340] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202] glycosaminoglycan binding [GO:0005539]; metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfate binding [GO:0043199]; sulfuric ester hydrolase activity [GO:0008484] AFQNVFAPR 1 1.6 0.77461 0.048033 0 0 0 0 0 0 0 0 0 11.1285 0 0 P15621 ZNF44_HUMAN Zinc finger protein 44 (Gonadotropin-inducible ovary transcription repressor 2) (GIOT-2) (Zinc finger protein 55) (Zinc finger protein 58) (Zinc finger protein KOX7) ZNF44 GIOT2 KOX7 ZNF55 ZNF58 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ECHEYAEK;QCGKAFRTSSSLR 2 3.2 0.95893 -1.0098 8.68429 7.79831 7.75255 8.35878 0 0 0 0 0 0 11.1154 0 P15692 VEGFA_HUMAN "Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]" VEGFA VEGF Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; basophil chemotaxis [GO:0002575]; bone trabecula formation [GO:0060346]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell development [GO:0055013]; cardiac vascular smooth muscle cell development [GO:0060948]; cell maturation [GO:0048469]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular stress response to acid chemical [GO:0097533]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; dopaminergic neuron differentiation [GO:0071542]; endothelial cell chemotaxis [GO:0035767]; endothelial cell proliferation [GO:0001935]; epithelial cell differentiation [GO:0030855]; epithelial cell maturation [GO:0002070]; eye photoreceptor cell development [GO:0042462]; heart morphogenesis [GO:0003007]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; induction of positive chemotaxis [GO:0050930]; kidney development [GO:0001822]; lactation [GO:0007595]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; lymph vessel morphogenesis [GO:0036303]; lymphangiogenesis [GO:0001946]; macrophage differentiation [GO:0030225]; mammary gland alveolus development [GO:0060749]; mesoderm development [GO:0007498]; monocyte differentiation [GO:0030224]; motor neuron migration [GO:0097475]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of establishment of endothelial barrier [GO:1903141]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; outflow tract morphogenesis [GO:0003151]; ovarian follicle development [GO:0001541]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of trophoblast cell migration [GO:1901165]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye development [GO:0031077]; primitive erythrocyte differentiation [GO:0060319]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of nitric oxide mediated signal transduction [GO:0010749]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; retinal ganglion cell axon guidance [GO:0031290]; sprouting angiogenesis [GO:0002040]; surfactant homeostasis [GO:0043129]; tube formation [GO:0035148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vasodilation [GO:0042311]; VEGF-activated neuropilin signaling pathway [GO:0038190] adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141]; VEGF-A complex [GO:1990150] chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor binding [GO:0005172] NFLLSWVHWSLALLLYLHHAK;SWSVPCGPCSER;TCRCDKPRR 3 19.5 0.97883 -1.9167 0 0 0 0 0 0 7.82197 0 10.4237 0 0 0 P15735 PHKG2_HUMAN "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2)" PHKG2 Homo sapiens (Human) generation of precursor metabolites and energy [GO:0006091]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321] DLISRLLQVDPEAR;EFYQKYDPK;HLIDNCAFRLYGHWIR;LLQVDPEAR;LSDFGFSCHLEPGEKLR;LSPEQLEEVR;LYGHWIRK;VALSTHR 8 19.8 0.9768 -4.8175 0 0 0 10.3925 10.0932 12.2583 10.8123 0 12.2652 13.4997 0 0 P15813 CD1D_HUMAN Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d) CD1D Homo sapiens (Human) "antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; detection of bacterium [GO:0016045]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; T cell selection [GO:0045058]" basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] beta-2-microglobulin binding [GO:0030881]; cell adhesion molecule binding [GO:0050839]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipid antigen binding [GO:0030882]; lipopeptide binding [GO:0071723] LFPLRCLQISSFANSSWTR 1 5.7 0.81156 -0.01416 0 12.3877 0 0 0 0 0 0 0 0 0 0 P15814 IGLL1_HUMAN Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b) IGLL1 IGL1 Homo sapiens (Human) immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; IgG immunoglobulin complex [GO:0071735]; membrane [GO:0016020] antigen binding [GO:0003823] SYSCQVMHEGSTVEK 1 7 0.78403 0.023703 0 0 0 0 0 6.77729 0 0 0 0 0 0 P15822 ZEP1_HUMAN Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) HIVEP1 ZNF40 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ACETQPK;HMKSKAHSK;QGKYICEYCNR 3 1 0.073409 0.4186 0 9.71857 0 0 0 0 0 0 0 0 0 0 P15848 ARSB_HUMAN Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) autophagy [GO:0006914]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943] LQFYHKHSVPVYFPAQDPRCDPK;NSMAPAK 2 5.6 0.8785 -0.13928 0 5.81085 0 0 0 0 0 0 0 0 0 7.23026 P15880 RS2_HUMAN Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) RPS2 RPS4 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ATFDAISK;ETVFTKSPYQEFTDHLVKTHTR;GAIILAK;GAIILAKLSIVPVR;GGFRGGFGSGIR;GRGARGGK;GTGIVSAPVPK;LSIVPVR;SPYQEFTDHLVK;TQAPAVATT 10 28.7 0 19.219 13.4588 13.0401 13.1723 9.6553 0 0 9.49599 8.53263 11.5752 13.1324 12.5079 9.31338 P15882 CHIN_HUMAN N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) CHN1 ARHGAP2 CHN Homo sapiens (Human) ephrin receptor signaling pathway [GO:0048013]; motor neuron axon guidance [GO:0008045]; regulation of axonogenesis [GO:0050770]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829] ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AAEYIAK;SYLYQLQQEAPHPR 2 4.6 0.95339 -0.78242 0 0 0 0 0 9.41032 0 0 0 0 0 0 P15884 ITF2_HUMAN Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) TCF4 BHLHB19 ITF2 SEF2 Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; regulation of transcription by RNA polymerase II [GO:0006357] beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; TFIIB-class transcription factor binding [GO:0001093]" NEMFSPPVSSGK;SSEDKKLDDDK 2 3.5 0.98072 -1.7931 0 0 0 0 0 0 9.26669 0 0 0 0 0 P15907 SIAT1_HUMAN "Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (B-cell antigen CD75) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)" ST6GAL1 SIAT1 Homo sapiens (Human) humoral immune response [GO:0006959]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of chemotaxis [GO:0050922]; negative regulation of macrophage apoptotic process [GO:2000110]; O-glycan processing [GO:0016266]; positive regulation of mononuclear cell proliferation [GO:0032946]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to ethanol [GO:0045471]; sialylation [GO:0097503]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138] "beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]" GPGPGIKFSAEALR;LAMGSDSQSVSSSSTQDPHRGR;NLIPRLQKIWK 3 11.6 0.95569 -0.98302 0 0 0 0 0 0 7.89984 0 11.8823 8.30702 7.98271 0 P15907 SIAT1_HUMAN "Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (B-cell antigen CD75) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)" ST6GAL1 SIAT1 Homo sapiens (Human) humoral immune response [GO:0006959]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of chemotaxis [GO:0050922]; negative regulation of macrophage apoptotic process [GO:2000110]; O-glycan processing [GO:0016266]; positive regulation of mononuclear cell proliferation [GO:0032946]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to ethanol [GO:0045471]; sialylation [GO:0097503]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138] "beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]" MNSQLVTTEKRFLK 1 8 0.56208 0.18258 0 0 4.4351 0 0 0 0 0 0 0 0 0 P15918 RAG1_HUMAN V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)] RAG1 RNF74 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; DNA recombination [GO:0006310]; immune response [GO:0006955]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; regulation of behavioral fear response [GO:2000822]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]; visual learning [GO:0008542] DNA recombinase complex [GO:0097519]; endodeoxyribonuclease complex [GO:1905347]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LMTKETVDAVCELIPSEER;SLQPNLQLSK;TPEEAQKEK;VMGSYCPSCRYPCFPTDLESPVK 4 5.8 0.97375 -1.4183 0 9.86089 0 9.58667 0 0 9.82914 0 0 0 4.54195 0 P15923 TFE2_HUMAN Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) TCF3 BHLHB21 E2A ITF1 Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell lineage commitment [GO:0002326]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; vitamin D response element binding [GO:0070644]" EDEENTSAADHSEEEK;GRPASLAGAQFGGSGK 2 4.9 0.4141 0.20142 0 0 0 0 0 0 0 2.17722 0 0 7.59111 0 P15924 DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) DSP Homo sapiens (Human) adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; ficolin-1-rich granule membrane [GO:0101003]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] AEFQEEAKRR;AELIVQPELK;AFIGFEGVK;AFIGFEGVKGKK;DANSENCNK;DNYQAFCK;DVLDGHLREK;ENRSLSEEIK;GAGSIAGASASPK;GIVDSITGQR;GLIDRDLYR;IEERCRR;IEVLEEELR;KSLLATMKTELQK;KSVEEVASEIQPFLR;LEDELNRAK;LESEKAIK;LPVEEAYKRGLVGIEFK;LSSEVEALR;LSSEVEALRR;LTYEIEDEK;NLRNQLDRLSR;QETWMLMELQKIRR;QVQTSQKNTLR;RLLQLQEQMRALYK;RQIEHCEGRMTLK;RVEEDIQQQK;RWEYENELSK;STLEAETR;TASEDSCK;VEAYRCGLK;VIETNRENDK;VLEQDKAR 33 11.2 0.97885 -13.835 13.2879 6.1612 13.9012 14.5352 14.5823 0 14.1183 10.3758 14.137 12.0513 12.2308 11.7224 P15924 DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) DSP Homo sapiens (Human) adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; ficolin-1-rich granule membrane [GO:0101003]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] AEFQEEAKRR;AELIVQPELK;AFIGFEGVK;AFIGFEGVKGKK;DANSENCNK;DNYQAFCK;GAGSIAGASASPK;GIVDSITGQR;GLIDRDLYR;IEERCRR;IEVLEEELR;KSLLATMKTELQK;KSVEEVASEIQPFLR;LEDELNRAK;LESEKAIK;LPVEEAYKRGLVGIEFK;LTYEIEDEK;NLRNQLDRLSR;QETWMLMELQKIRR;QVQTSQKNTLR;RLLQLQEQMRALYK;RQIEHCEGRMTLK;RWEYENELSK;RWEYENELSKASNR;STLEAETR;VEAYRCGLK;VIETNRENDK;VLEQDKAR 28 11.4 0.86504 -0.087065 0 0 0 0 0 0 0 0 10.519 0 0 0 P15941 MUC1_HUMAN Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; positive regulation of transcription by RNA polymerase II [GO:0045944]" apical plasma membrane [GO:0016324]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712] NYGQLDIFPAR;YVPPSSTDRSPYEK 2 2 0.95695 -1.0237 0 0 0 0 0 0 0 3.22565 0 0 0 0 P16035 TIMP2_HUMAN Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) TIMP2 Homo sapiens (Human) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] metalloendopeptidase inhibitor activity [GO:0008191]; molecular function inhibitor activity [GO:0140678]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270] NINGHQAKFFACIK;RIQYEIKQIK 2 10.9 0.9368 -0.53818 0 0 0 0 0 0 11.3415 11.4649 11.5001 0 11.4661 10.7157 P16050 LOX15_HUMAN "Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)" ALOX15 LOG15 Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; arachidonate metabolic process [GO:0019369]; bone mineralization [GO:0030282]; cellular response to calcium ion [GO:0071277]; cellular response to interleukin-13 [GO:0035963]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; inflammatory response [GO:0006954]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of adaptive immune response [GO:0002820]; ossification [GO:0001503]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of inflammatory response [GO:0050727]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] "arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" TDVAVKDDPELQTWCR 1 2.4 0.91656 -0.42592 0 0 0 0 0 0 0 0 0 8.78156 0 0 P16066 ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) NPR1 ANPRA Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; dopamine metabolic process [GO:0042417]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114] ANPR-A receptor complex [GO:1990620]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; G protein-coupled peptide receptor activity [GO:0008528]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672] AGPSYAK;ELASELWR;LLLLLLLPPLLLLLR;LLRTMPRK;LRLLLLLLLPPLLLLLR;RPAGSRLRLLLLLLLPPLLLLLR;VLFELKHMR 7 5.2 0.97795 -2.164 8.4363 0 0 0 5.83986 0 15.6966 4.9534 10.159 15.2261 5.91917 0 P16070 CD44_HUMAN CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) CD44 LHR MDU2 MDU3 MIC4 Homo sapiens (Human) "cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cytokine-mediated signaling pathway [GO:0019221]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; monocyte aggregation [GO:0070487]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of monocyte aggregation [GO:1900625]; regulation of lamellipodium morphogenesis [GO:2000392]; T cell activation [GO:0042110]; wound healing, spreading of cells [GO:0044319]" apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; macrophage migration inhibitory factor receptor complex [GO:0035692]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] collagen binding [GO:0005518]; hyaluronic acid binding [GO:0005540]; transmembrane signaling receptor activity [GO:0004888] AFNSTLPTMAQMEK;DGTRYVQKGEYR;TEAADLCK 3 4.6 0.98106 -1.7908 0 0 0 0 0 0 0 0 0 0 10.9409 7.02137 P16083 NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) NQO2 NMOR2 Homo sapiens (Human) quinone catabolic process [GO:1901662] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] "chloride ion binding [GO:0031404]; dihydronicotinamide riboside quinone reductase activity [GO:0001512]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; melatonin binding [GO:1904408]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; protein homodimerization activity [GO:0042803]; resveratrol binding [GO:1905594]; zinc ion binding [GO:0008270]" EADLVIFQFPLYWFSVPAILK;KVLIVYAHQEPK 2 14.3 0.2526 0.27809 0 8.64587 5.25501 0 0 0 0 0 0 0 0 0 P16104 H2AX_HUMAN Histone H2AX (H2a/x) (Histone H2A.X) H2AX H2AFX Homo sapiens (Human) cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; cerebral cortex development [GO:0021987]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; heterochromatin formation [GO:0031507]; meiotic cell cycle [GO:0051321]; nucleosome assembly [GO:0006334]; positive regulation of DNA repair [GO:0045739]; protein localization to site of double-strand break [GO:1990166]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; XY body [GO:0001741] chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGLQFPVGR;HLQLAIR;LLGGVTIAQGGVLPNIQAVLLPK;NDEELNK;TSATVGPK 5 37.8 0.057823 0.44982 6.37952 6.75676 0 0 0 0 0 0 0 0 0 0 P16109 LYAM3_HUMAN P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; defense response to Gram-negative bacterium [GO:0050829]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; regulation of integrin activation [GO:0033623]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; platelet dense granule membrane [GO:0031088] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; fucose binding [GO:0042806]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; oligosaccharide binding [GO:0070492]; sialic acid binding [GO:0033691] SPSAPGK 1 0.8 0.68844 0.16248 0 0 0 0 0 0 0 0 0 11.2315 0 0 P16118 F261_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB1 F6PK PFRX Homo sapiens (Human) "animal organ regeneration [GO:0031100]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; positive regulation of glycolytic process through fructose-6-phosphate [GO:1904540]; response to cAMP [GO:0051591]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to starvation [GO:0042594]" "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex [GO:0043540]; cytosol [GO:0005829]" "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]" CLLAYFLDK;VESIYLNVEAVNTHR 2 5.1 0.61817 0.17396 4.78146 0 0 0 0 0 0 0 0 0 0 0 P16144 ITB4_HUMAN Integrin beta-4 (GP150) (CD antigen CD104) ITGB4 Homo sapiens (Human) autophagy [GO:0006914]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; filopodium assembly [GO:0046847]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; mesodermal cell differentiation [GO:0048333]; nail development [GO:0035878]; peripheral nervous system myelin formation [GO:0032290]; response to wounding [GO:0009611]; skin morphogenesis [GO:0043589]; trophoblast cell migration [GO:0061450] basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; integrin complex [GO:0008305]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] EPWPNSDPPFSFKNVISLTEDVDEFRNK;GHCECGR;SATPGPPGEHLVNGR 3 2.7 0.87663 -0.13436 0 8.41903 6.49313 5.05037 0 5.83362 0 0 0 0 0 0 P16150 LEUK_HUMAN Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] SPN CD43 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; establishment or maintenance of cell polarity [GO:0007163]; immune response [GO:0006955]; leukocyte tethering or rolling [GO:0050901]; negative regulation of cell adhesion [GO:0007162]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type IV hypersensitivity [GO:0001808]; negative thymic T cell selection [GO:0045060]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of defense response to virus [GO:0050688]; regulation of immune response [GO:0050776]; regulation of T cell migration [GO:2000404]; response to protozoan [GO:0001562]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T-helper 1 cell lineage commitment [GO:0002296] basement membrane [GO:0005604]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; PML body [GO:0016605]; uropod [GO:0001931] heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; transmembrane signaling receptor activity [GO:0004888] GMLPVAVLVALLAVIVLVALLLLWR;MYTTSITSDPK 2 9 0.87349 -0.11415 0 0 5.29943 0 0 0 0 0 0 11.5416 0 0 P16152 CBR1_HUMAN "Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)" CBR1 CBR CRN SDR21C1 Homo sapiens (Human) cyclooxygenase pathway [GO:0019371]; epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561] "15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]" EGWPSSAYGVTK;GQAAVQQLQAEGLSPR;IGVTVLSRIHARK;LSEQRKGDK;SSGIHVALVTGGNK;VVNVSSIMSVR 6 27.1 0 9.2322 12.2651 0 0 0 0 0 11.1729 11.8043 0 10.1062 10.7993 0 P16157 ANK1_HUMAN Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) cytoskeleton organization [GO:0007010]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165] ankyrin-1 complex [GO:0170014]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; M band [GO:0031430]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; Z disc [GO:0030018] ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; protein phosphatase binding [GO:0019903]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] CYCMTDDKVDK;ELTAVPYMAK;RVCRIITTDFPLYFVIMSR 3 2.1 0.93805 -0.5714 0 0 7.67016 0 0 0 0 0 11.1938 0 0 0 P16157 ANK1_HUMAN Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) cytoskeleton organization [GO:0007010]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165] ankyrin-1 complex [GO:0170014]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; M band [GO:0031430]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; Z disc [GO:0030018] ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; protein phosphatase binding [GO:0019903]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] GSLCFVLK 1 5.2 0.9151 -0.39033 0 0 0 0 0 0 0 9.83845 0 0 0 0 P16234 PGFRA_HUMAN Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) PDGFRA PDGFR2 RHEPDGFRA Homo sapiens (Human) adrenal gland development [GO:0030325]; cardiac myofibril assembly [GO:0055003]; cell activation [GO:0001775]; cell chemotaxis [GO:0060326]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; estrogen metabolic process [GO:0008210]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; hematopoietic progenitor cell differentiation [GO:0002244]; in utero embryonic development [GO:0001701]; Leydig cell differentiation [GO:0033327]; lung development [GO:0030324]; luteinization [GO:0001553]; male genitalia development [GO:0030539]; metanephric glomerular capillary formation [GO:0072277]; negative regulation of platelet activation [GO:0010544]; odontogenesis of dentin-containing tooth [GO:0042475]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mesenchymal stem cell differentiation [GO:2000739]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; white fat cell differentiation [GO:0050872]; wound healing [GO:0042060] cell junction [GO:0030054]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phospholipase C activator activity [GO:0160185]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] SELTVAAAVLVLLVIVIISLIVLVVIWK;SLYDRPASYK;SLYDRPASYKK 3 3.6 0.96554 -1.1479 0 0 0 0 0 0 0 0 0 3.40558 0 0 P16278 BGAL_HUMAN Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) GLB1 ELNR1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid catabolic process [GO:0046479]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate catabolic process [GO:0042340]; response to cortisone [GO:0051413]; response to Thyroglobulin triiodothyronine [GO:1904016] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuole [GO:0005773] beta-galactosidase activity [GO:0004565]; galactoside binding [GO:0016936]; protein homodimerization activity [GO:0042803] GLRNATQRMFEIDYSR;GQVWINGFNLGR;ILPLLLVLLLLGPTRGLR;PGFLVRILPLLLVLLLLGPTRGLR 4 7.2 0.73281 0.11953 0 0 0 9.61967 0 2.59817 0 0 11.1819 7.98294 0 0 P16284 PECA1_HUMAN Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) PECAM1 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diapedesis [GO:0050904]; establishment of endothelial barrier [GO:0061028]; glomerular endothelium development [GO:0072011]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; monocyte extravasation [GO:0035696]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to cell-cell junction [GO:0150107]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667] protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888] DQNFVILEFPVEEQDR;GLIAVVIIGVIIALLIIAAK;ILTVRVILAPWK;KGLIAVVIIGVIIALLIIAAK;SELVTVTESFSTPK 5 8.5 0.033088 0.56567 4.14633 0 7.00191 4.95061 9.23656 3.09023 0 10.4516 0 0 10.8997 9.39307 P16298 PP2BB_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) PPP3CB CALNA2 CALNB CNA2 Homo sapiens (Human) axon extension [GO:0048675]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-ion regulated exocytosis [GO:0017156]; dephosphorylation [GO:0016311]; heart development [GO:0007507]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; lymphangiogenesis [GO:0001946]; memory [GO:0007613]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of signaling [GO:0023057]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lysosome organization [GO:1905673]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to cytokine [GO:0034097]; response to stress [GO:0006950]; signal transduction [GO:0007165]; skeletal muscle fiber development [GO:0048741]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098] calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; T-tubule [GO:0030315]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AIGKMAR;AVPFPPTHRLTSEEVFDLDGIPR;LTSEEVFDLDGIPR;VFSVLREESESVLTLK 4 8.8 0.91343 -0.38684 0 0 0 10.4397 0 0 10.4414 0 9.1558 4.65764 0 0 P16333 NCK1_HUMAN SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) NCK1 NCK Homo sapiens (Human) "actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; response to endoplasmic reticulum stress [GO:0034976]; signal complex assembly [GO:0007172]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]" cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506] cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein sequestering activity [GO:0140311]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159] AQGKNKHFK;FNYMAER;INGMVGLVPK;VIVMEKCSDGWWR 4 10.3 0.96661 -1.2695 0 10.5331 10.6722 0 0 0 9.93943 0 0 0 10.4851 0 P16383 GCFC2_HUMAN Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) GCFC2 C2orf3 GCF TCF9 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type post-mRNA release spliceosomal complex [GO:0071008] DNA binding [GO:0003677] ELSSTVK;LESTGLK;LLNPLIRVQLIDWNPLKLESTGLK;LLNRYLIIALLNATPGPDVVK 4 6.7 0.95272 -0.76552 0 0 0 0 7.63198 0 0 0 0 0 8.66445 0 P16401 H15_HUMAN Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) H1-5 H1F5 HIST1H1B Homo sapiens (Human) chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; establishment of protein localization to chromatin [GO:0071169]; muscle organ development [GO:0007517]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; protein stabilization [GO:0050821] chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] AAGAGAAK;AAGAGAAKR;ALAAGGYDVEK;ALAAGGYDVEKNNSR;ATGPPVSELITK;AVKKTPK;GTGASGSFK;GTLVQTK;KATGPPVSELITK;LGLKSLVSKGTLVQTK;NGLSLAALK;NGLSLAALKK;SETAPAETATPAPVEK 13 42 0 95.496 14.8931 15.0198 14.504 13.8524 13.4157 13.6653 13.9551 14.4117 14.5238 15.3548 15.2948 11.3958 P16402 H13_HUMAN Histone H1.3 (Histone H1c) (Histone H1s-2) H1-3 H1F3 HIST1H1D Homo sapiens (Human) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334] chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] AGATAGK;ALAAAGYDVEK;ALAAAGYDVEKNNSR;ASGPPVSELITK;GTGASGSFK;GTLVQTK;KASGPPVSELITK;KPAGAAK;KVAGAATPK;LGLKSLVSKGTLVQTK;SETAPLAPTIPAPAEK;SGVSLAALK;SGVSLAALKK;VAGAATPK;VAGAATPKK 15 46.6 0 76.369 16.7523 18.6986 16.5125 14.6079 13.8081 14.137 14.8788 15.6596 15.7531 16.01 16.0905 14.9791 P16403 H12_HUMAN Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) H1-2 H1F2 HIST1H1C Homo sapiens (Human) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334] euchromatin [GO:0000791]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] ALAAAGYDVEK;ALAAAGYDVEKNNSR;ASGPPVSELITK;GTGASGSFK;GTLVQTK;KASGPPVSELITK;KPAAATVTK;LGLKSLVSKGTLVQTK;SETAPAAPAAAPPAEK;SGVSLAALK;SGVSLAALKK 11 41.3 0 18.476 12.678 12.9231 13.059 0 13.4105 13.8158 12.6479 0 0 13.8029 13.749 0 P16422 EPCAM_HUMAN Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326) EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 Homo sapiens (Human) negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; ureteric bud development [GO:0001657] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] cadherin binding involved in cell-cell adhesion [GO:0098641]; protein-containing complex binding [GO:0044877] AEMNGSK;SLRTALQKEITTR 2 6.4 0.9516 -0.68814 7.14017 0 8.1637 0 0 0 0 0 0 0 0 0 P16435 NCPR_HUMAN NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR CYPOR Homo sapiens (Human) electron transport chain [GO:0022900]; nitric oxide biosynthetic process [GO:0006809]; organofluorine metabolic process [GO:0090346]; positive regulation of monooxygenase activity [GO:0032770]; response to hormone [GO:0009725]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958] GVATNWLRAK;NPFLAAVTTNR;QYELVVHTDIDAAK;YYSIASSSK 4 6.5 0.95214 -0.75472 0 11.2318 11.3581 0 0 0 0 0 11.3447 8.339 0 0 P16452 EPB42_HUMAN Protein 4.2 (P4.2) (Erythrocyte membrane protein band 4.2) (Erythrocyte protein 4.2) EPB42 E42P Homo sapiens (Human) cell morphogenesis [GO:0000902]; erythrocyte maturation [GO:0043249]; hemoglobin metabolic process [GO:0020027]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of cell shape [GO:0008360]; spleen development [GO:0048536] ankyrin-1 complex [GO:0170014]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural constituent of cytoskeleton [GO:0005200] EDAVFLK;GDAQISVTLVNHSEQEK;GQALGIK;GSVPILR;VEKEKMER 5 6.7 0.97874 -2.048 0 0 7.64003 0 0 7.36466 7.01201 0 12.2235 11.2075 0 0 P16471 PRLR_HUMAN Prolactin receptor (PRL-R) PRLR Homo sapiens (Human) activation of Janus kinase activity [GO:0042976]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cytokine-mediated signaling pathway [GO:0019221]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; prostate gland growth [GO:0060736]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; response to bacterium [GO:0009617]; steroid biosynthetic process [GO:0006694] cell surface [GO:0009986]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; prolactin receptor activity [GO:0004925]; protein kinase binding [GO:0019901] ETFTCWWRPGTDGGLPTNYSLTYHR;SREEGKATQQR 2 5.8 0.76529 0.060673 9.22627 3.13731 0 0 0 0 0 0 0 0 0 0 P16473 TSHR_HUMAN Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) TSHR LGR3 Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to glycoprotein [GO:1904588]; cellular response to thyrotropin-releasing hormone [GO:1905229]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; thyroid-stimulating hormone signaling pathway [GO:0038194]" basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled peptide receptor activity [GO:0008528]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; thyroid-stimulating hormone receptor activity [GO:0004996] DLGGMGCSSPPCECHQEEDFR;GLEHLKELIAR;NTRNLTYIDPDALK;QAQAYRGQR;VTCKDIQR 5 8.2 0.97304 -2.5167 0 0 0 9.69471 0 10.6412 0 3.15971 0 0 6.24346 0 P16499 PDE6A_HUMAN "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)" PDE6A PDEA Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" ITYHNWR;LHGSSILER;LQVGFIDFVCTFVYKEFSR;NKADELPKLQVGFIDFVCTFVYK;TPDGREINFYK 5 6.3 0.94122 -0.60682 0 0 0 10.2522 0 0 0 0 0 7.03067 0 0 P16519 NEC2_HUMAN Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 NEC2 Homo sapiens (Human) enkephalin processing [GO:0034230]; insulin processing [GO:0030070]; islet amyloid polypeptide processing [GO:0034231]; nervous system development [GO:0007399]; peptide hormone processing [GO:0016486]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] dendrite [GO:0030425]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] serine-type endopeptidase activity [GO:0004252] DWKTVPER;VGFDKWPFMTTHTWGEDAR 2 4.2 0.91721 -0.35689 0 0 0 0 8.18725 10.237 0 0 0 0 0 0 P16520 GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3) GNB3 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of blood pressure [GO:0008217]; regulation of cholesterol metabolic process [GO:0090181]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression [GO:0010468]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of phospholipid metabolic process [GO:1903725]; regulation of triglyceride metabolic process [GO:0090207] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; signaling receptor complex adaptor activity [GO:0030159]; spectrin binding [GO:0030507] ELSAHTGYLSCCR;GEMEQLRQEAEQLK;VGILSGHDNR 3 10.9 0.88533 -0.18146 0 0 0 0 0 0 10.3512 0 6.65907 0 0 0 P16562 CRIS2_HUMAN Cysteine-rich secretory protein 2 (CRISP-2) (Cancer/testis antigen 36) (CT36) (Testis-specific protein TPX-1) CRISP2 GAPDL5 TPX1 Homo sapiens (Human) extracellular space [GO:0005615] ALLPVLFLVTVLLPSLPAEGK;EKCKATCLCENK;NTPYQQGTPCAGCPDDCDK 3 21.4 0.9614 -1.0648 0 5.18432 0 4.56541 0 0 0 0 0 0 0 0 P16581 LYAM2_HUMAN E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 Homo sapiens (Human) actin filament-based process [GO:0030029]; calcium-mediated signaling [GO:0019722]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of receptor internalization [GO:0002092]; regulation of inflammatory response [GO:0050727]; response to cytokine [GO:0034097]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612] caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; phospholipase binding [GO:0043274]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888] DVGMWNDERCSK;LQCGPTGEWDNEKPTCEAVR 2 5.2 0.90819 -0.27499 0 4.76458 0 0 0 6.46783 0 0 0 9.69066 0 0 P16591 FER_HUMAN Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; adherens junction disassembly [GO:0120179]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; germ cell development [GO:0007281]; insulin receptor signaling pathway [GO:0008286]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of STAT protein [GO:0007260] adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase 1 binding [GO:0008157]; protein tyrosine kinase activity [GO:0004713] EDLPQELK;GYRMSAPQHCPEDISKIMMK;LSKFESIR;SWLLMIQQTEQLSRIMK;VQENDGKEPPPVVNYEEDAR 5 8.9 0.95595 -0.84349 0 0 0 0 0 10.1664 0 8.73816 0 0 0 10.1381 P16615 AT2A2_HUMAN "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)" ATP2A2 ATP2B Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell adhesion [GO:0007155]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epidermis development [GO:0008544]; ER-nucleus signaling pathway [GO:0006984]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of heart contraction [GO:0045822]; negative regulation of receptor binding [GO:1900121]; neuron cellular homeostasis [GO:0070050]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of heart rate [GO:0010460]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to endoplasmic reticulum stress [GO:0034976]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; transition between fast and slow fiber [GO:0014883] calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; longitudinal sarcoplasmic reticulum [GO:0014801]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; ribbon synapse [GO:0097470]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; lncRNA binding [GO:0106222]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086039]; S100 protein binding [GO:0044548]; transmembrane transporter binding [GO:0044325] EFDELNPSAQR;FVARNYLEPAILE;GLSKIERANACNSVIK;IGIFGQDEDVTSK;ISLPVILMDETLK;MNVFDTELK;TASEMVLADDNFSTIVAAVEEGR;TGTLTTNQMSVCR;VGEATETALTCLVEK;VIMITGDNK;VPMTSGVK 11 14.3 0.0087527 1.0765 8.48776 13.0662 8.892 0 9.67858 0 9.17956 8.99811 5.60727 10.0109 10.0001 0 P16662 UD2B7_HUMAN "UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)" UGT2B7 UGTB2B9 Homo sapiens (Human) androgen metabolic process [GO:0008209]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] CCLFCFWK;VINDPSYK 2 3 0.93347 -0.51439 0 0 0 10.9346 0 0 0 0 0 0 0 0 P16671 CD36_HUMAN Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36) CD36 GP3B GP4 Homo sapiens (Human) "amyloid fibril formation [GO:1990000]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to hydroperoxide [GO:0071447]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cGMP-mediated signaling [GO:0019934]; cholesterol import [GO:0070508]; cholesterol transport [GO:0030301]; defense response to Gram-positive bacterium [GO:0050830]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; lipid transport across blood-brain barrier [GO:1990379]; lipoprotein transport [GO:0042953]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle mediated signaling [GO:0055096]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitric oxide-cGMP-mediated signaling [GO:0038060]; oxidised low-density lipoprotein particle clearance [GO:0150024]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of tumor necrosis factor production [GO:0032760]; production of molecular mediator involved in inflammatory response [GO:0002532]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of action potential [GO:0098900]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein-containing complex assembly [GO:0043254]; regulation of removal of superoxide radicals [GO:2000121]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to fatty acid [GO:0070542]; response to linoleic acid [GO:0070543]; response to lipid [GO:0033993]; response to stilbenoid [GO:0035634]; sensory perception of taste [GO:0050909]; short-chain fatty acid transport [GO:0015912]; triglyceride transport [GO:0034197]" apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; caveola [GO:0005901]; cell periphery [GO:0071944]; cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid immune receptor activity [GO:0070892]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; oleate transmembrane transporter activity [GO:1901480]; oxidised low-density lipoprotein particle receptor activity [GO:0150025]; protein-containing complex binding [GO:0044877]; scavenger receptor activity [GO:0005044]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; thrombospondin receptor activity [GO:0070053]; Toll-like receptor binding [GO:0035325]; transforming growth factor beta binding [GO:0050431] GPYTYRVR;LQVNLLVKPSEKIQVLK;RLQVNLLVKPSEKIQVLK 3 5.5 0.97504 -1.4448 13.268 0 0 0 5.61105 0 0 0 0 0 9.28341 0 P16860 ANFB_HUMAN Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] NPPB Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cardiac conduction system development [GO:0003161]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; protein folding [GO:0006457]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]; vasodilation [GO:0042311] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] diuretic hormone activity [GO:0008613]; hormone activity [GO:0005179]; hormone receptor binding [GO:0051427]; signaling receptor binding [GO:0005102] MVQGSGCFGR;SREVATEGIR 2 14.9 0.98107 -1.7476 0 0 12.2446 0 0 0 0 0 0 0 0 0 P16871 IL7RA_HUMAN Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) IL7R Homo sapiens (Human) B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular homeostasis [GO:0019725]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; interleukin-7-mediated signaling pathway [GO:0038111]; lymph node development [GO:0048535]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of cell size [GO:0008361]; regulation of DNA recombination [GO:0000018]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913] clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; cytokine receptor activity [GO:0004896]; interleukin-7 receptor activity [GO:0004917] VLMHDVAYR 1 2 0.90534 -0.27101 0 0 12.1631 0 0 0 0 0 0 0 0 0 P16885 PLCG2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)" PLCG2 Homo sapiens (Human) "antifungal innate immune response [GO:0061760]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cellular response to calcium ion [GO:0071277]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; Fc-epsilon receptor signaling pathway [GO:0038095]; follicular B cell differentiation [GO:0002316]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of programmed cell death [GO:0043069]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; platelet activation [GO:0030168]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of receptor internalization [GO:0002092]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; programmed cell death [GO:0012501]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of lipid metabolic process [GO:0019216]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110] ALELGTVMTVFSFRKSTPER;ALYDYKAK;EPGGWWKGDYGTR;NQSIAIELSDLVVYCKPTSK;REGSDSYAITFRAR;TKDNLENPDFR;YNQKGLTRVYPK 7 7.7 0.95517 -0.85982 0 9.6764 0 0 0 7.164 9.18088 9.24802 11.7051 10.4516 0 0 P16930 FAAA_HUMAN Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) FAH Homo sapiens (Human) arginine catabolic process [GO:0006527]; homogentisate catabolic process [GO:1902000]; L-phenylalanine catabolic process [GO:0006559]; lipid metabolic process [GO:0006629]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; extracellular exosome [GO:0070062] fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872] LGEPIPISK 1 2.1 0.10136 0.36814 0 0 0 0 0 0 0 0 0 9.32549 0 0 P16949 STMN1_HUMAN Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) STMN1 C1orf215 LAP18 OP18 Homo sapiens (Human) axonogenesis [GO:0007409]; establishment of skin barrier [GO:0061436]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neuron projection development [GO:0031175]; regulation of cell migration [GO:0030334]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to virus [GO:0009615]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005] tubulin binding [GO:0015631] ASGQAFELILSPR;DLSLEEIQK;EAQMAAK 3 19.5 0.95444 -0.80198 0 0 0 0 9.07759 0 0 0 0 0 0 0 P17014 ZNF12_HUMAN Zinc finger protein 12 (Gonadotropin-inducible ovary transcription repressor 3) (GIOT-3) (Zinc finger protein 325) (Zinc finger protein KOX3) ZNF12 GIOT3 KOX3 ZNF325 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AYECYECGK;CSECGKCFCRK;LEQGEEPWIVEGEFLLQSYPDEVWQTDDLIER;SFCQKGTLTVHQR;TFYQNSALCRHR 5 11 0.97764 -1.5182 0 0 0 10.8465 0 6.57292 0 0 0 0 6.97568 5.8652 P17017 ZNF14_HUMAN Zinc finger protein 14 (Gonadotropin-inducible ovary transcription repressor 4) (GIOT-4) (Zinc finger protein KOX6) ZNF14 GIOT4 KOX6 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ECGKAFNSSNSCR;NLVCLGKK;TFIYYQSFQKHAHTGKKPYECK 3 6.7 0.97981 -2.0022 0 0 0 0 0 0 0 0 0 0 7.0705 0 P17019 ZN708_HUMAN Zinc finger protein 708 (Zinc finger protein 15) (Zinc finger protein 15-like 1) (Zinc finger protein KOX8) ZNF708 KOX8 ZNF15 ZNF15L1 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SFCMLSQLTQHEIIHTGEKPYK;SFILSSHLTTHK;VFHKYSNAK 3 7.6 0.96456 -1.1524 0 0 0 0 0 0 0 7.32346 0 9.64629 0 0 P17022 ZNF18_HUMAN Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LPTCRECGKTFYR;NSQLIFHQR 2 4 0.98088 -1.6969 0 0 0 0 0 0 0 9.34356 0 0 0 0 P17023 ZNF19_HUMAN Zinc finger protein 19 (Zinc finger protein KOX12) ZNF19 KOX12 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFNGNSSLIR;MAAMPLK 2 3.7 0.97948 -1.8859 0 0 0 0 0 0 0 8.79012 0 9.73176 0 0 P17024 ZNF20_HUMAN Zinc finger protein 20 (Zinc finger protein KOX13) ZNF20 KOX13 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HCGKAFISNYIR;KAFSYLDSFQSHDKACTK 2 5.6 0.93586 -0.53348 0 0 0 0 7.98237 8.10481 0 0 0 0 7.73627 0 P17025 ZN182_HUMAN Zinc finger protein 182 (Zinc finger protein 21) (Zinc finger protein KOX14) ZNF182 KOX14 ZNF21 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LFFHTEYEK 1 1.4 0.93206 -0.49281 0 0 0 0 0 0 0 12.0982 0 0 0 0 P17027 ZNF23_HUMAN Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16) ZNF23 KOX16 ZNF359 ZNF612 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AFSVNGK 1 1.1 0.91211 -0.3229 0 0 0 0 0 0 0 0 0 0 0 8.34634 P17028 ZNF24_HUMAN Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) ZNF24 KOX17 ZNF191 ZSCAN3 Homo sapiens (Human) myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" HFSQGSALILHQR 1 3.5 0.80476 0.013493 0 0 0 0 0 0 0 0 0 0 0 3.95559 P17029 ZKSC1_HUMAN Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) ZKSCAN1 KOX18 ZNF139 ZNF36 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELCHQWLRPEINTK;IEDMAVSLILEEWGCQNLARR;RFCYQNTFGPR;TITGERGPREK 4 10.1 0.98038 -1.8637 0 0 0 0 0 8.80954 10.5229 0 0 0 8.20389 0 P17031 ZNF26_HUMAN Zinc finger protein 26 (Zinc finger protein KOX20) ZNF26 KOX20 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASLQIHQKTHSGEKPFKCSECGK;HQRAHSIEKNCVCSECGK;IHRKTHK 3 9 0.97988 -2.0419 0 0 0 0 10.672 10.4297 0 0 0 7.8339 0 0 P17032 ZN37A_HUMAN Zinc finger protein 37A (Zinc finger protein KOX21) ZNF37A KOX21 ZNF37 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FNEFNKGGK;ITSQGSVSFR 2 3.4 0.937 -0.56291 0 0 0 0 0 0 0 0 0 8.68201 0 0 P17035 ZNF28_HUMAN Zinc finger protein 28 (Zinc finger protein KOX24) ZNF28 KOX24 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEECDKVFRCK;IGNQVEK;LHSGEKP;SDSCLTEHQRVHTGEKPYMCNECGK;SINNASSVSTSQR;TLYRDVMLENYR 6 11.4 0.98018 -1.6499 0 11.2149 0 0 8.72938 0 0 10.3989 9.19896 13.9015 13.9442 0 P17036 ZNF3_HUMAN Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) ZNF3 KOX25 Homo sapiens (Human) cell differentiation [GO:0030154]; leukocyte activation [GO:0045321]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" CDECSKSFNR;IHTGENPYECSECGK 2 5.6 0.92662 -0.45443 0 0 0 0 0 0 0 0 0 0 0 5.82652 P17038 ZNF43_HUMAN Zinc finger protein 43 (Zinc finger protein 39) (Zinc finger protein HTF6) (Zinc finger protein KOX27) ZNF43 KOX27 ZNF39 ZNF39L1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNHFSILTKHKR;AFNQYSNLTTHNKIHTGEK;AFNWPSTLTKHK;ISHTEKK;LTHTGEKPYK;RIHTGEKPYTCEECGK;SVDECKVHR;VNFCKCEK 8 11.6 0.97509 -4.0511 0 9.93511 0 0 0 9.00003 0 11.6283 0 6.15496 10.4049 0 P17039 ZNF30_HUMAN Zinc finger protein 30 (Zinc finger protein KOX28) ZNF30 KOX28 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFRLNSFLTEHQR 1 2.1 0.95289 -0.67741 0 0 0 0 0 0 0 11.4395 0 0 0 0 P17040 ZSC20_HUMAN Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29) ZSCAN20 KOX29 ZNF31 ZNF360 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CFSERSK;LCALGFLRTLEQCRYR;TLEQCRYRVK;WLRPEIRLK 4 4 0.96541 -1.2418 9.3658 0 0 6.59319 5.33967 0 0 0 7.13924 0 0 0 P17040 ZSC20_HUMAN Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29) ZSCAN20 KOX29 ZNF31 ZNF360 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGKNMGV;TLEQCRYRVK;WLRPEIRLK 3 6 0.98077 -1.6199 0 0 0 9.30984 0 8.67515 0 0 0 0 0 0 P17041 ZNF32_HUMAN Zinc finger protein 32 (C2H2-546) (Zinc finger protein KOX30) ZNF32 KOX30 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GSLAVHQR;SFRNQSNLAVHRR;SPDSKTLQEDSPGVRQR 3 13.9 0.97544 -1.4461 0 8.46181 0 0 0 0 0 10.3417 0 8.2949 0 4.56645 P17050 NAGAB_HUMAN Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Homo sapiens (Human) carbohydrate catabolic process [GO:0016052]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]; protein homodimerization activity [GO:0042803] SLIEVYMRPLSNK;VNYSLLADICNLWR 2 6.6 0.84775 -0.069087 9.32968 12.2455 0 0 0 0 0 0 0 0 0 0 P17066 HSP76_HUMAN Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) HSPA6 HSP70B' Homo sapiens (Human) cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986] blood microparticle [GO:0072562]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] ATAGDTHLGGEDFDNR;DNNLLGR;ELNKSINPDEAVAYGAAVQAAVLMGDK;IINEPTAAAIAYGLDR;ITITNDK;ITITNDKGR;LLQDFFNGK;LLQDFFNGKELNK;LSKEEVER;STLEPVEK;TACERAK;TTPSYVAFTDTER;VEILANDQGNR;VEILANDQGNRTTPSYVAFTDTER 14 20.4 0 13.769 13.4085 13.3501 13.3748 10.765 11.2324 10.8496 9.95375 0 8.84323 13.3869 13.4424 11.6374 P17096 HMGA1_HUMAN High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) HMGA1 HMGIY Homo sapiens (Human) base-excision repair [GO:0006284]; DNA unwinding involved in DNA replication [GO:0006268]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; oncogene-induced cell senescence [GO:0090402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; transcription regulator complex [GO:0005667] "5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; structural constituent of chromatin [GO:0030527]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]" EPSEVPTPK;KQPPVSPGTALVGSQK;SSQPLASK 3 30.8 0 6.8001 0 9.84389 12.2899 0 0 0 11.7364 10.3922 10.3737 0 0 0 P17097 ZNF7_HUMAN Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) ZNF7 KOX4 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFGCSSR;HQRTHTGEKPFKCDECGK;HQRTHTGERPYPCK;LIQHQRIHTGEKPYRCEECGK 4 8.7 0.94672 -0.65706 0 0 10.3882 0 0 7.47192 0 0 8.08523 0 8.70183 0 P17098 ZNF8_HUMAN Zinc finger protein 8 (Zinc finger protein HF.18) ZNF8 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AFNQNSSLGR;RIHTGERPYMCKECGK 2 4.5 0.92212 -0.44322 0 0 0 0 0 6.20441 0 0 0 0 0 11.3732 P17152 TMM11_HUMAN "Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI)" TMEM11 C17orf35 PM1 Homo sapiens (Human) inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] LSRLPLHTLTSSTPVVLVRK 1 10.4 0.46566 0.19077 0 0 0 0 0 0 0 0 7.52286 0 0 0 P17174 AATC_HUMAN "Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)" GOT1 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; malate-aspartate shuttle [GO:0043490]; Notch signaling pathway [GO:0007219]; oxaloacetate metabolic process [GO:0006107]; response to glucocorticoid [GO:0051384] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine transaminase activity [GO:0047801]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170] APPSVFAEVPQAQPVLVFK;LALGDDSPALK;SYRYWDAEKR;VGGVQSLGGTGALR 4 13.1 0 3.4183 10.8757 12.3905 10.6711 0 0 9.56562 0 0 0 9.6444 0 0 P17181 INAR1_HUMAN Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) IFNAR1 IFNAR Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; positive regulation of cellular respiration [GO:1901857]; response to lipopolysaccharide [GO:0032496]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; JAK pathway signal transduction adaptor activity [GO:0008269]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905] AEKENTSSWYEVDSFTPFR;CNFSSLKLNVYEEIKLR;LNVYEEIK;LSPETTYCLK 4 8.3 0.96473 -1.2515 0 0 0 9.24959 9.86338 5.76866 0 0 10.569 0 0 12.2481 P17213 BPI_HUMAN Bactericidal permeability-increasing protein (BPI) (CAP 57) BPI Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of macrophage activation [GO:0043031]; negative regulation of tumor necrosis factor production [GO:0032720] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; specific granule lumen [GO:0035580] lipopolysaccharide binding [GO:0001530] IESALRNKMNSQVCEK;IPDYSDSFKIKHLGK 2 6.4 0.7325 0.11846 0 0 0 0 0 0 0 8.2885 0 0 5.85629 0 P17252 KPCA_HUMAN Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) PRKCA PKCA PRKACA Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cell adhesion [GO:0007155]; desmosome assembly [GO:0002159]; intracellular signal transduction [GO:0035556]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glial cell apoptotic process [GO:0034351]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of angiogenesis [GO:0045766]; positive regulation of angiotensin-activated signaling pathway [GO:0110063]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of bone resorption [GO:0045780]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; regulation of platelet aggregation [GO:0090330]; response to interleukin-1 [GO:0070555] alphav-beta3 integrin-PKCalpha complex [GO:0035866]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol binding [GO:0019992]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme binding [GO:0019899]; histone H3T6 kinase activity [GO:0035403]; integrin binding [GO:0005178]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]" EIQPPFKPK;GIIYRDLK;GPDTDDPR;LENREIQPPFKPK;LKPSDKDRR;SLSKEAVSVCK 6 7.3 0.97665 -5.4874 0 0 0 0 9.84433 7.74268 0 0 0 11.1844 0 0 P17275 JUNB_HUMAN Transcription factor JunB (Transcription factor AP-1 subunit JunB) JUNB Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; decidualization [GO:0046697]; embryonic process involved in female pregnancy [GO:0060136]; integrated stress response signaling [GO:0140467]; labyrinthine layer blood vessel development [GO:0060716]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; response to steroid hormone [GO:0048545]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ALDDLHK;LAATKCRK 2 4.3 0.92722 -0.45572 0 0 0 0 0 0 0 12.683 10.0369 0 0 12.2146 P17301 ITA2_HUMAN Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) ITGA2 CD49B Homo sapiens (Human) "animal organ morphogenesis [GO:0009887]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; collagen-activated signaling pathway [GO:0038065]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; hepatocyte differentiation [GO:0070365]; hypotonic response [GO:0006971]; integrin-mediated signaling pathway [GO:0007229]; mammary gland development [GO:0030879]; mesodermal cell differentiation [GO:0048333]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell projection organization [GO:0031346]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of translation [GO:0045727]; positive regulation of transmission of nerve impulse [GO:0051971]; response to amine [GO:0014075]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to muscle activity [GO:0014850]; response to parathyroid hormone [GO:0071107]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; substrate-dependent cell migration [GO:0006929]" axon terminus [GO:0043679]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha2-beta1 complex [GO:0034666]; integrin complex [GO:0008305]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; heparan sulfate proteoglycan binding [GO:0043395]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618] AEVPTGVIIGSIIAGILLLLALVAILWKLGFFKR;VTSRGLFKENNER 2 4 0.97428 -2.4097 0 9.93661 0 0 0 0 0 0 0 0 0 0 P17342 ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) NPR3 ANPRC C5orf23 NPRC Homo sapiens (Human) angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; negative regulation of cold-induced thermogenesis [GO:0120163]; osteoclast proliferation [GO:0002158]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] chloride ion binding [GO:0031404]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803] DGGKIIQQTWNR;ELREDSIR;SVEGNGTGRRLLPPGTR;VAPAYAK 4 8.1 0.97439 -3.5307 9.88299 0 0 10.7246 6.72451 0 0 0 0 9.30111 0 0 P17405 ASM_HUMAN "Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form]" SMPD1 ASM Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; cellular response to UV [GO:0034644]; ceramide biosynthetic process [GO:0046513]; cholesterol metabolic process [GO:0008203]; glycosphingolipid catabolic process [GO:0046479]; negative regulation of MAPK cascade [GO:0043409]; nervous system development [GO:0007399]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of viral entry into host cell [GO:0046598]; response to cocaine [GO:0042220]; response to interleukin-1 [GO:0070555]; response to ionizing radiation [GO:0010212]; response to tumor necrosis factor [GO:0034612]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]; symbiont entry into host cell [GO:0046718]; termination of signal transduction [GO:0023021]; wound healing [GO:0042060] endolysosome [GO:0036019]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886] "acid sphingomyelin phosphodiesterase activity [GO:0061750]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphatidylcholine phospholipase C activity [GO:0034480]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]" ARETYGLPNTLPTAWHNLVYRMR;IVPRLRDVFGWGNLTCPICK 2 6.8 0.74417 0.098815 0 0 0 0 0 0 0 0 0 8.74446 8.38793 0 P17480 UBF1_HUMAN Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) UBTF UBF UBF1 Homo sapiens (Human) positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; RNA polymerase I cis-regulatory region sequence-specific DNA binding [GO:0001165]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; scaffold protein binding [GO:0097110] AEEIWQQSVIGDYLARFK;ILSKKYK;ISQSQKEHYK;KEKLMWIK;LHPEMSNLDLTK;LRGPNPK 6 8.1 0.97517 -4.1945 0 0 0 0 9.40276 0 0 4.60472 12.2295 0 0 0 P17482 HXB9_HUMAN Homeobox protein Hox-B9 (Homeobox protein Hox-2.5) (Homeobox protein Hox-2E) HOXB9 HOX2E Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell chemotaxis [GO:0060326]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; mammary gland development [GO:0030879]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TWLEPAPR 1 3.2 0.91379 -0.39033 0 0 0 0 0 0 0 0 0 0 8.66956 0 P17509 HXB6_HUMAN Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2) HOXB6 HOX2B Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte homeostasis [GO:0034101]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MNSCNSSSFGPSGR;QTYTRYQTLELEK 2 12.1 0.91589 -0.4324 6.18291 0 0 0 0 0 0 0 0 0 0 10.8597 P17516 AK1C4_HUMAN Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) AKR1C4 CHDR Homo sapiens (Human) androgen metabolic process [GO:0008209]; bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; cellular response to jasmonic acid stimulus [GO:0071395]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; bile acid transmembrane transporter activity [GO:0015125]; chlordecone reductase activity [GO:0047743]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" EDIFYTSK;GVVVLAK;QTPALIALRYQLQRGVVVLAK;REDIFYTSK;SIGVSNFNCR 5 12.4 0.84103 -0.050324 0 0 0 8.03083 7.37808 0 0 0 0 0 0 0 P17538 CTRB1_HUMAN Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] CTRB1 CTRB Homo sapiens (Human) digestion [GO:0007586]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] VTKLIPWVQK 1 3.8 0.88867 -0.18654 0 0 0 0 0 0 0 0 9.92162 0 0 0 P17540 KCRS_HUMAN "Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)" CKMT2 Homo sapiens (Human) muscle contraction [GO:0006936]; phosphocreatine biosynthetic process [GO:0046314] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] EQPRLFPPSADYPDLR;EQPRLFPPSADYPDLRK;MASIFSK;SEVELVQIVIDGVNYLVDCEKK 4 11 0.94129 -0.5895 0 0 10.7505 0 7.71582 0 10.2108 0 0 0 0 0 P17600 SYN1_HUMAN Synapsin-1 (Brain protein 4.1) (Synapsin I) SYN1 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091] axon [GO:0030424]; cell body [GO:0044297]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptonemal complex [GO:0000795] actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein-membrane anchor activity [GO:0106006]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] QAGPPQATR;QLIVELVVNK;TSVSGNWK 3 3.8 0.96231 -1.0757 11.5638 11.3003 11.0778 9.03681 0 9.1697 10.4723 10.041 0 9.47628 9.2032 11.7458 P17655 CAN2_HUMAN Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) CAPN2 CANPL2 Homo sapiens (Human) behavioral response to pain [GO:0048266]; blastocyst development [GO:0001824]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; female pregnancy [GO:0007565]; myoblast fusion [GO:0007520]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; protein autoprocessing [GO:0016540]; protein catabolic process at postsynapse [GO:0140249]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cytoskeleton organization [GO:0051493]; regulation of interleukin-6 production [GO:0032675]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; synaptic vesicle endocytosis [GO:0048488] calpain complex [GO:0110158]; chromatin [GO:0000785]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; pseudopodium [GO:0031143] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] LGLKEFYILWTKIQK;LTKMDGNWR;MAGIAAK;YQKIYREIDVDR 4 6.1 0.97427 -2.4331 0 0 12.3144 0 9.23201 9.70641 0 5.23001 0 0 0 0 P17677 NEUM_HUMAN Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) GAP43 Homo sapiens (Human) astrocyte differentiation [GO:0048708]; axon choice point recognition [GO:0016198]; axon regeneration [GO:0031103]; cell fate commitment [GO:0045165]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]; regulation of filopodium assembly [GO:0051489]; regulation of growth [GO:0040008]; regulation of postsynaptic specialization assembly [GO:0099150]; response to auditory stimulus [GO:0010996]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246] cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; GABA-ergic synapse [GO:0098982]; growth cone membrane [GO:0032584]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793] calmodulin binding [GO:0005516]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786] AGSAETESATK;AHKAATK;AVRPSPYSLGFLTFWISRVEK 3 14.2 0.91746 -0.39921 9.81949 0 4.67897 0 0 0 0 10.267 5.6425 0 0 0 P17693 HLAG_HUMAN "HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]" HLA-G HLA-6.0 HLAG Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; cellular defense response [GO:0006968]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of angiogenesis [GO:0016525]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of immune response [GO:0050777]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; peripheral B cell tolerance induction [GO:0002451]; positive regulation of cellular senescence [GO:2000774]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; protein homotrimerization [GO:0070207]" cis-Golgi network membrane [GO:0033106]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; filopodium membrane [GO:0031527]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] WAAVVVPSGEEQR;WSKEGDGGIMSVR 2 11.5 0.9207 -0.44391 0 0 0 0 5.4832 0 0 0 0 0 0 0 P17693 HLAG_HUMAN "HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]" HLA-G HLA-6.0 HLAG Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; cellular defense response [GO:0006968]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of angiogenesis [GO:0016525]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of immune response [GO:0050777]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; peripheral B cell tolerance induction [GO:0002451]; positive regulation of cellular senescence [GO:2000774]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; protein homotrimerization [GO:0070207]" cis-Golgi network membrane [GO:0033106]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; filopodium membrane [GO:0031527]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] GYYNQSEASE 1 8.6 0.32488 0.24594 0 9.95703 0 0 0 0 0 0 0 0 0 0 P17706 PTN2_HUMAN Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) PTPN2 PTPT Homo sapiens (Human) B cell differentiation [GO:0030183]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of type II interferon-mediated signaling pathway [GO:0060334]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome lumen [GO:0031904]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]" ETGFSVKLLSEDVK;PTTIEREFEELDTQRR;QVLLNMR;RWQPLYLEIRNESHDYPHR 4 13.3 0.97738 -2.1722 12.4389 0 0 0 0 0 0 0 10.8691 0 0 0 P17707 DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] AMD1 AMD Homo sapiens (Human) polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597] cytosol [GO:0005829] adenosylmethionine decarboxylase activity [GO:0004014]; identical protein binding [GO:0042802]; putrescine binding [GO:0019810] QEAYVLSESSMFVSKR 1 4.8 0.54105 0.18469 0 0 0 0 0 0 0 0 0 9.4339 0 0 P17735 ATTY_HUMAN Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) TAT Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; response to dexamethasone [GO:0071548]; response to mercury ion [GO:0046689]; response to oxidative stress [GO:0006979]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829] amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-tyrosine-2-oxoglutarate transaminase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170] LSQRILGPCTIVQGALKSILCR 1 4.8 0.56099 0.18276 0 0 0 0 0 0 4.14706 0 0 0 0 0 P17752 TPH1_HUMAN Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) TPH1 TPH TPRH TRPH Homo sapiens (Human) aromatic amino acid metabolic process [GO:0009072]; bone remodeling [GO:0046849]; circadian rhythm [GO:0007623]; mammary gland alveolus development [GO:0060749]; negative regulation of ossification [GO:0030279]; platelet degranulation [GO:0002576]; positive regulation of fat cell differentiation [GO:0045600]; regulation of hemostasis [GO:1900046]; response to immobilization stress [GO:0035902]; serotonin biosynthetic process [GO:0042427] cytosol [GO:0005829]; neuron projection [GO:0043005] iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510] ASLIFSLKNEVGGLIKALK 1 4.3 0.53365 0.18649 0 0 0 0 0 0 0 6.55519 0 0 0 0 P17812 PYRG1_HUMAN CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) CTPS1 CTPS Homo sapiens (Human) 'de novo' CTP biosynthetic process [GO:0044210]; B cell proliferation [GO:0042100]; CTP biosynthetic process [GO:0006241]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleobase biosynthetic process [GO:0019856]; response to xenobiotic stimulus [GO:0009410]; T cell proliferation [GO:0042098] cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802] FVGQDVEGER;GLGLSPDLVVCR;SGSSSPDSEITELKFPSINHD 3 7.3 0.97804 -1.5022 10.7026 0 0 0 0 0 0 0 0 0 0 12.3581 P17813 EGLN_HUMAN Endoglin (CD antigen CD105) ENG END Homo sapiens (Human) artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphorylation [GO:0042325]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] cell surface [GO:0009986]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] activin binding [GO:0048185]; coreceptor activity [GO:0015026]; galactose binding [GO:0005534]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor activator activity [GO:0030546]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transmembrane signaling receptor activity [GO:0004888]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114] LNIISPDLSGCTSK;TLEWRPR 2 3.2 0.91737 -0.4092 0 0 0 0 0 0 0 0 0 0 0 12.3538 P17844 DDX5_HUMAN Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) DDX5 G17P1 HELR HLR1 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; BMP signaling pathway [GO:0030509]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; miRNA transcription [GO:0061614]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription [GO:0009299]; myoblast differentiation [GO:0045445]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; primary miRNA processing [GO:0031053]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of viral genome replication [GO:0045069]; rhythmic process [GO:0048511]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; MH2 domain binding [GO:0035500]; mRNA 3'-UTR binding [GO:0003730]; nuclear androgen receptor binding [GO:0050681]; pre-mRNA binding [GO:0036002]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; SMAD binding [GO:0046332] APILIATDVASR;EANQAINPK;GLDVEDVK;MLDMGFEPQIR;TGTAYTFFTPNNIK;TTYLVLDEADR 6 10.6 0.0047506 1.4722 0 0 0 0 0 0 0 0 8.68068 9.15492 9.65433 0 P17858 PFKAL_HUMAN "ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)" PFKL Homo sapiens (Human) "canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]" 6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] AIGVLTSGGDAQGMNAAVR;MGIYVGAK;VNVEHMTEK 3 4.6 0.93538 -0.53465 0 0 0 0 0 0 0 0 0 0 13.66 0 P17858 PFKAL_HUMAN "ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)" PFKL Homo sapiens (Human) "canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]" 6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] GLSRSPQQETGFAK;MGIYVGAK;VNVEHMTEK 3 3.7 0.91829 -0.43596 0 0 10.942 0 0 0 0 0 0 0 0 0 P17861 XBP1_HUMAN "X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 TREB5 XBP2 Homo sapiens (Human) adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; ATF6-mediated unfolded protein response [GO:0036500]; autophagy [GO:0006914]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; ERAD pathway [GO:0036503]; exocrine pancreas development [GO:0031017]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glandular epithelial cell maturation [GO:0002071]; immune response [GO:0006955]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]" IEEAPLSPSENDHPEFIVSVK;LTHLSPEEKALR 2 8.8 0.93604 -0.5357 0 0 0 0 0 10.0933 8.64252 0 0 0 0 0 P17931 LEG3_HUMAN Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) LGALS3 MAC2 Homo sapiens (Human) eosinophil chemotaxis [GO:0048245]; epithelial cell differentiation [GO:0030855]; innate immune response [GO:0045087]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mononuclear cell migration [GO:0071674]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of NK T cell activation [GO:0051134]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell receptor signaling pathway [GO:0050860]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of T cell apoptotic process [GO:0070232]; regulation of T cell proliferation [GO:0042129]; RNA splicing [GO:0008380] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; immunological synapse [GO:0001772]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spliceosomal complex [GO:0005681] carbohydrate binding [GO:0030246]; chemoattractant activity [GO:0042056]; disaccharide binding [GO:0048030]; IgE binding [GO:0019863]; laminin binding [GO:0043236]; molecular condensate scaffold activity [GO:0140693]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; receptor ligand inhibitor activity [GO:0141069]; RNA binding [GO:0003723]; signaling receptor inhibitor activity [GO:0030547] FNENNRR;GNDVAFHFNPR;IALDFQR;IALDFQRGNDVAFHFNPRFNENNR;MLITILGTVKPNANR;QSVFPFESGKPFK 6 21.2 0 3.6108 0 12.7788 13.1142 10.6909 0 10.3687 11.3872 11.9971 10.6898 10.2307 0 0 P17948 VGFR1_HUMAN Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) FLT1 FLT FRT VEGFR1 Homo sapiens (Human) blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; hyaloid vascular plexus regression [GO:1990384]; monocyte chemotaxis [GO:0002548]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323] actin cytoskeleton [GO:0015629]; endosome [GO:0005768]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] FTWTDSKPKASLK;GEAAHKWSLPEMVSKESER;GLYTCRVR;IIWDSRK;VTEEDEGVYHCKATNQK;VVQASAFGIKKSPTCR 6 6 0.97671 -4.9485 0 9.44626 9.58643 8.63615 0 11.2099 8.84555 0 0 8.2006 10.114 0 P17980 PRS6A_HUMAN 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) PSMC3 TBP1 Homo sapiens (Human) modulation by host of viral transcription [GO:0043921]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402] IMKSEVLRVTHELQAMK;MNVSPDVNYEELARCTDDFNGAQCK;QTYFLPVIGLVDAEK;VIAATNRVDILDPALLR 4 16.9 0.89694 -0.24585 6.13251 0 0 0 8.53158 8.34283 8.26181 0 8.37682 4.94776 0 0 P17987 TCPA_HUMAN T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) TCP1 CCT1 CCTA Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]; tubulin complex assembly [GO:0007021] acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterochromatin [GO:0000792]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] EQLAIAEFAR;MEGPLSVFGDR;QAGVFEPTIVK;SLLVIPNTLAVNAAQDSTDLVAK;SQNVMAAASIANIVK;SSLGPVGLDK;YPVNSVNILK 7 16.2 0 33.031 13.5506 11.8459 12.8844 10.576 9.15297 9.12122 12.756 12.7868 12.3308 9.30624 11.5625 11.9967 P18054 LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (EC 1.13.11.-) (Arachidonate (12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Arachidonate (15S)-lipoxygenase) (EC 1.13.11.33) (Linoleate (13S)-lipoxygenase) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) ALOX12 12LO LOG12 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; establishment of skin barrier [GO:0061436]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; leukotriene A4 metabolic process [GO:1901751]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxin B4 biosynthetic process [GO:2001306]; lipoxygenase pathway [GO:0019372]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of platelet aggregation [GO:0090331]; superoxide anion generation [GO:0042554]; unsaturated fatty acid metabolic process [GO:0033559] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; sarcolemma [GO:0042383] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; hepoxilin-epoxide hydrolase activity [GO:0047977]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165] AGALEMALKR 1 1.5 0.73981 0.10326 0 0 8.02547 0 0 0 0 0 0 0 0 0 P18065 IBP2_HUMAN Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) IGFBP2 BP2 IBP2 Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; osteoblast differentiation [GO:0001649]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; protein phosphatase inhibitor activity [GO:0004864]; receptor ligand inhibitor activity [GO:0141069]; signaling receptor binding [GO:0005102]; signaling receptor inhibitor activity [GO:0030547] ISTMRLPDER;MPCAELVREPGCGCCSVCAR;VTEQHRQMGK 3 12.3 0.97484 -1.3894 0 0 0 0 9.90366 0 0 0 0 11.6416 0 0 P18074 ERCC2_HUMAN General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 5.6.2.3) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA 5'-3' helicase XPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein) ERCC2 XPD XPDC Homo sapiens (Human) "apoptotic process [GO:0006915]; bone mineralization [GO:0030282]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; determination of adult lifespan [GO:0008340]; embryonic cleavage [GO:0040016]; embryonic organ development [GO:0048568]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; positive regulation of mitotic recombination [GO:0045951]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; spinal cord development [GO:0021510]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]" CAK-ERCC2 complex [GO:0070516]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; damaged DNA binding [GO:0003684]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded 3'-5' DNA helicase activity [GO:1990518]" GAILLSVAR 1 1.2 0.90943 -0.3116 0 0 0 0 0 0 7.95146 0 0 0 0 0 P18077 RL35A_HUMAN Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein) RPL35A GIG33 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] AIFAGYK;DETEFYLGK;MSGRLWSKAIFAGYK;NNTVTPGGKPNK;VMLYPSRI 5 40 0.91881 -0.40249 10.5779 0 0 0 0 9.02981 0 10.5168 0 0 9.86067 0 P18084 ITB5_HUMAN Integrin beta-5 ITGB5 Homo sapiens (Human) "cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta5 complex [GO:0034684]; integrin complex [GO:0008305]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618] DAPEGGFDAVLQAAVCKEKIGWR;GDCSCNQCSCFESEFGK;GHCLCGQCQCTEPGAFGEMCEK;LTSNFRLGFGSFVDK;REFAKFQSER;SLGTKLAEEMRK 6 12.4 0.97247 -2.8381 6.66278 0 0 0 8.46455 10.0585 0 0 0 8.76673 0 0 P18085 ARF4_HUMAN ADP-ribosylation factor 4 ARF4 ARF2 Homo sapiens (Human) "apical protein localization [GO:0045176]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; dendritic spine development [GO:0060996]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular protein transport [GO:0006886]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of postsynapse organization [GO:0099175]; regulation of reactive oxygen species metabolic process [GO:2000377]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]" cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] epidermal growth factor receptor binding [GO:0005154]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; phospholipase D activator activity [GO:1990583] ILMVGLDAAGK;IQEVADELQK 2 11.7 0 2.9951 12.2621 10.9259 12.8269 10.4219 9.65473 0 0 0 11.5531 11.5293 11.3316 10.979 P18089 ADA2B_HUMAN Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) ADRA2B ADRA2L1 ADRA2RL1 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; MAPK cascade [GO:0000165]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of blood pressure [GO:0045777]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of uterine smooth muscle contraction [GO:0070474]; receptor transactivation [GO:0035624]; regulation of vascular associated smooth muscle contraction [GO:0003056] cell surface [GO:0009986]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379] IKCIILTVWLIAAVISLPPLIYKGDQGPQPR;RFTFVLAVVIGVFVLCWFPFFFSYSLGAICPK 2 14 0.19054 0.3364 0 5.59329 4.61206 0 0 0 0 0 11.5026 0 0 0 P18124 RL7_HUMAN Large ribosomal subunit protein uL30 (60S ribosomal protein L7) RPL7 Homo sapiens (Human) "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AGNFYVPAEPK;ASINMLR;EVPAVPETLK;GINGVSPK;HYHKEYRQMYR;IALTDNALIAR;IVEPYIAWGYPNLK;MEGVEEK;QIFNGTFVK;SVNELIYK;TTHFVEGGDAGNREDQINR 11 46.4 0 23.435 0 14.2819 13.5084 9.99166 10.0067 10.0126 11.0533 12.3096 12.7027 12.9139 12.8083 7.16812 P18146 EGR1_HUMAN Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) EGR1 KROX24 ZNF225 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cellular response to gamma radiation [GO:0071480]; cellular response to heparin [GO:0071504]; cellular response to interleukin-8 [GO:0098759]; cellular response to mycophenolic acid [GO:0071506]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; estrous cycle [GO:0044849]; glomerular mesangial cell proliferation [GO:0072110]; interleukin-1-mediated signaling pathway [GO:0070498]; locomotor rhythm [GO:0045475]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of glomerular metanephric mesangial cell proliferation [GO:0072303]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron apoptotic process [GO:0043523]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of protein sumoylation [GO:0033233]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; skeletal muscle cell differentiation [GO:0035914]; T cell differentiation [GO:0030217] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; histone acetyltransferase binding [GO:0035035]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" SDELTRHIRIHTGQKPFQCR 1 3.7 0.47387 0.19077 0 0 0 0 0 0 0 9.93533 0 0 0 0 P18206 VINC_HUMAN Vinculin (Metavinculin) (MV) VCL Homo sapiens (Human) adherens junction assembly [GO:0034333]; apical junction assembly [GO:0043297]; axon extension [GO:0048675]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; lamellipodium assembly [GO:0030032]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]; platelet aggregation [GO:0070527]; protein localization to cell surface [GO:0034394]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization to adherens junction [GO:1904702] adherens junction [GO:0005912]; brush border [GO:0005903]; cell projection [GO:0042995]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fascia adherens [GO:0005916]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inner dense plaque of desmosome [GO:0090637]; membrane raft [GO:0045121]; outer dense plaque of desmosome [GO:0090636]; plasma membrane [GO:0005886]; podosome ring [GO:0061826]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; terminal web [GO:1990357]; zonula adherens [GO:0005915] actin binding [GO:0003779]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] AGEVINQPMMMAAR;ALASQLQDSLK;AVAGNISDPGLQK;DEEFPEQK;ELTPQVVSAAR;IPTISTQLK;LANVMMGPYR;LEAMTNSKQSIAK;LNQAKGWLR;MSAEINEIIR;NLGPGMTKMAK;NLGPGMTKMAKMIDER;NRNFTVEK;QQELTHQEHR;RALIQCAK;SLGEISALTSK;STVEGIQASVK;VMLVNSMNTVK 18 16.1 0.97474 -3.76 12.4346 13.435 12.1766 8.64641 0 0 12.5025 0 13.2876 12.2318 0 12.1546 P18283 GPX2_HUMAN Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2) (Phospholipid hydroperoxide glutathione peroxidase GPX2) (EC 1.11.1.12) GPX2 Homo sapiens (Human) response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686] electron transfer activity [GO:0009055]; glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066] FLIGPEGEPFR 1 5.8 0.91134 -0.32516 0 0 0 9.86115 0 0 0 0 0 0 0 0 P18405 S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) SRD5A1 Homo sapiens (Human) androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cellular response to testosterone stimulus [GO:0071394]; cerebral cortex development [GO:0021987]; diterpenoid metabolic process [GO:0016101]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; liver development [GO:0001889]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; pituitary gland development [GO:0021983]; progesterone metabolic process [GO:0042448]; response to estrogen [GO:0043627]; response to follicle-stimulating hormone [GO:0032354]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to muscle activity [GO:0014850]; response to xenobiotic stimulus [GO:0009410]; serotonin metabolic process [GO:0042428]; sex determination [GO:0007530]; spinal cord development [GO:0021510]; steroid biosynthetic process [GO:0006694]; thalamus development [GO:0021794]; urogenital system development [GO:0001655] cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471] 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity [GO:0047751]; amide binding [GO:0033218]; electron transfer activity [GO:0009055]; NADPH binding [GO:0070402] HALPSHR 1 2.7 0.91121 -0.32557 0 0 0 0 0 0 0 0 0 0 6.28978 0 P18428 LBP_HUMAN Lipopolysaccharide-binding protein (LBP) LBP Homo sapiens (Human) acute-phase response [GO:0006953]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide transport [GO:0015920]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of tumor necrosis factor production [GO:0032720]; neutrophil chemotaxis [GO:0030593]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] coreceptor activity [GO:0015026]; lipopeptide binding [GO:0071723]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; signaling receptor binding [GO:0005102] FQKVLESRICEMIQK;LAEGFPLPLLKRVQLYDLGLQIHK;LSVATNVSATLTFNTSKITGFLKPGK;SFRPFVPR;VRKSFFK 5 16.6 0.96821 -1.3249 0 7.5812 0 0 0 0 11.9654 10.3582 0 5.99871 0 0 P18433 PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; modulation of chemical synaptic transmission [GO:0050804]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" EETVNDFWR;VDVYGFVSR 2 2.2 0.95253 -0.74905 0 0 0 0 0 0 0 0 0 0 7.34376 0 P18440 ARY1_HUMAN Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1) NAT1 AAC1 Homo sapiens (Human) xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829] arylamine N-acetyltransferase activity [GO:0004060] DIEAYLER;LTEENGFWYLDQIR;LVPKHGDR;NIFNISLQRKLVPK 4 13.8 0.9772 -2.2363 0 0 0 0 11.1569 0 0 0 0 10.956 0 8.78852 P18507 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) (GABAAR subunit gamma-2) GABRG2 Homo sapiens (Human) "adult behavior [GO:0030534]; cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; post-embryonic development [GO:0009791]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" axon [GO:0030424]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; dendritic spine [GO:0043197]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DCASFFCCFEDCRTGAWR;DEEYGYECLDGKDCASFFCCFEDCR;VAGISDGYPR 3 7.8 0.90982 -0.30055 0 0 8.00068 7.21655 5.06751 0 0 0 0 0 5.25108 0 P18509 PACA_HUMAN Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] ADCYAP1 Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; insulin secretion [GO:0030073]; negative regulation of cell cycle [GO:0045786]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of protein localization [GO:0032880] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; perikaryon [GO:0043204] neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; pituitary adenylate cyclase activating polypeptide activity [GO:0016521]; signaling receptor binding [GO:0005102]; type 1 vasoactive intestinal polypeptide receptor binding [GO:0031891]; type 2 vasoactive intestinal polypeptide receptor binding [GO:0031892] AAAAWYRPAGRR;YLAAVLGKRYK;YRKQMAVK 3 17.6 0.97562 -2.3236 0 0 0 0 0 0 10.5954 0 0 13.8373 11.9004 0 P18510 IL1RA_HUMAN Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra) IL1RN IL1F3 IL1RA Homo sapiens (Human) acute-phase response [GO:0006953]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; insulin secretion [GO:0030073]; lipid metabolic process [GO:0006629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; response to glucocorticoid [GO:0051384] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "cytokine activity [GO:0005125]; interleukin-1 receptor antagonist activity [GO:0005152]; interleukin-1 receptor binding [GO:0005149]; interleukin-1 type I receptor antagonist activity [GO:0045352]; interleukin-1 type II receptor antagonist activity [GO:0045353]; interleukin-1, type I receptor binding [GO:0005150]; interleukin-1, type II receptor binding [GO:0005151]" ALETICRPSGR 1 6.9 0.7924 0.016544 0 0 0 0 0 0 0 0 0 6.51467 0 0 P18564 ITB6_HUMAN Integrin beta-6 ITGB6 Homo sapiens (Human) bone development [GO:0060348]; bronchiole development [GO:0060435]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to ionizing radiation [GO:0071479]; enamel mineralization [GO:0070166]; hard palate development [GO:0060022]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; lung alveolus development [GO:0048286]; phospholipid homeostasis [GO:0055091]; response to virus [GO:0009615]; skin development [GO:0043588]; surfactant homeostasis [GO:0043129]; transforming growth factor beta production [GO:0071604]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing [GO:0042060] cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alphav-beta6 complex [GO:0034685]; integrin complex [GO:0008305]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; virus receptor activity [GO:0001618] CECGEDMLSTDSCK;EVAKFEAER;LGFGSFVEKPVSPFVK;TIIHSINEK 4 6.1 0.91613 -0.34505 10.739 0 0 0 0 0 0 4.99204 0 0 10.5302 0 P18583 SON_HUMAN Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 Homo sapiens (Human) "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607] DNA binding [GO:0003677]; RNA binding [GO:0003723] AGIEGPLLASDVGR;SMMSSYERSMMSYER;SMMSYERSMMSPMAERSMMSAYER;SRSVVRR 4 2.2 0.97641 -2.1844 0 0 0 0 0 0 7.4776 0 0 9.31059 7.50732 0 P18615 NELFE_HUMAN Negative elongation factor E (NELF-E) (RNA-binding protein RD) NELFE RD RDBP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chromatin binding [GO:0003682]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] LVIPPGLSEEEEALQKKFNK;SDSFPERR;SLYESFDWGYEER;SRTLEGKLK 4 14.3 0.97454 -2.4406 0 9.3789 0 7.43404 0 0 0 0 0 0 11.8419 0 P18621 RL17_HUMAN Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) RPL17 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EQIVPKPEEEVAQK;NAESNAELK;QWGWTQGRWPK;YSLDPENPTK 4 23.9 0 6.1041 0 12.3358 10.9824 9.23728 9.21089 0 0 0 0 0 12.2005 10.5991 P18669 PGAM1_HUMAN Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) PGAM1 PGAMA CDABP0006 Homo sapiens (Human) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]; protein kinase binding [GO:0019901]" ALPFWNEEIVPQIK;AMEAVAAQGK;HYGGLTGLNK;SYDVPPPPMEPDHPFYSNISK;VLIAAHGNSLR 5 26 0 15.622 11.6729 13.1488 13.03 10.2612 10.1288 8.96619 13.1267 13.1311 12.4342 12.3954 12.0811 12.9622 P18825 ADA2C_HUMAN Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) ADRA2C ADRA2L2 ADRA2RL2 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of insulin secretion [GO:0046676]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; receptor transactivation [GO:0035624]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229] cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886] alpha-2A adrenergic receptor binding [GO:0031694]; alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] SFKHILFRR;VAQAREKR 2 3.7 0.97524 -1.4405 0 10.161 0 0 0 0 0 0 0 0 0 0 P18848 ATF4_HUMAN Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) ATF4 CREB2 TXREB Homo sapiens (Human) bone mineralization [GO:0030282]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; circadian regulation of gene expression [GO:0032922]; embryonic hemopoiesis [GO:0035162]; endoplasmic reticulum unfolded protein response [GO:0030968]; gamma-aminobutyric acid signaling pathway [GO:0007214]; gluconeogenesis [GO:0006094]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-asparagine metabolic process [GO:0070982]; lens fiber cell morphogenesis [GO:0070309]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron differentiation [GO:0030182]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; regulation of synaptic plasticity [GO:0048167]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636]; transcription by RNA polymerase II [GO:0006366] ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; centrosome [GO:0005813]; CHOP-ATF4 complex [GO:1990617]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; Lewy body core [GO:1990037]; neuron projection [GO:0043005]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] "cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" NEALKERADSLAK 1 3.7 0.95899 -1.0354 0 0 0 0 0 0 0 11.6111 0 0 0 0 P18850 ATF6A_HUMAN Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] ATF6 Homo sapiens (Human) ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; visual perception [GO:0007601] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ESACQSRKK 1 1.3 0.82551 -0.019567 0 0 0 0 0 0 0 0 0 10.3989 0 0 P18858 DNLI1_HUMAN DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) LIG1 Homo sapiens (Human) "anatomical structure morphogenesis [GO:0009653]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; lagging strand elongation [GO:0006273]; mismatch repair [GO:0006298]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]" intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; metal ion binding [GO:0046872] DIEQIAEFLEQSVK;FPRFIRVR;IFSRNQEDNTGK;TLDVDATYEIAKR 4 5.1 0.95497 -0.78711 0 0 0 0 0 0 10.8611 0 0 0 6.48435 12.116 P18887 XRCC1_HUMAN DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) XRCC1 Homo sapiens (Human) base-excision repair [GO:0006284]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; voluntary musculoskeletal movement [GO:0050882] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]" 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572] ALELGAKYRPDWTR;WIYSCNEK;WIYSCNEKQK;YSQVLGLGGRIVRK 4 6 0.97848 -1.9368 3.22186 0 0 0 8.70449 0 0 0 7.59813 0 0 11.4014 P19012 K1C15_HUMAN "Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)" KRT15 KRTB Homo sapiens (Human) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; nucleus [GO:0005634] scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200] ALEEANADLEVK;CEMEAQNQEYK;EFSSQLAGQVNVEMDAAPGVDLTRVLAEMR;EQYEAMAEK;LAADDFR;LAADDFRLKYENELALR;LASYLDK;LASYLDKVR;LEQEIATYR;VLDELTLAR 10 23.2 0.95215 -0.77106 0 0 0 0 6.69766 0 0 10.3246 0 0 5.20348 0 P19013 K2C4_HUMAN "Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)" KRT4 CYK4 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of epithelial cell proliferation [GO:0050680] cell surface [GO:0009986]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] AQYEEIAQR;EYQELMSVK;FASFIDK;GFSCGSAIVGGGKR;MIARQQCVR 5 9.2 0.96522 -1.1353 0 0 0 0 0 0 0 0 0 0 0 4.5888 P19021 AMD_HUMAN Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM Homo sapiens (Human) fatty acid primary amide biosynthetic process [GO:0062112]; peptide amidation [GO:0001519]; response to zinc ion [GO:0010043] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]; zinc ion binding [GO:0008270] EPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKK;SDAREGAEHER 2 4.5 0.57987 0.18088 0 0 0 0 0 0 0 0 0 4.28747 0 0 P19021 AMD_HUMAN Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM Homo sapiens (Human) fatty acid primary amide biosynthetic process [GO:0062112]; peptide amidation [GO:0001519]; response to zinc ion [GO:0010043] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]; zinc ion binding [GO:0008270] AGIEVQEIKGK;SDAREGAEHER 2 2.5 0.98096 -1.7369 0 11.0765 0 0 0 0 0 0 0 8.87817 0 0 P19022 CADH2_HUMAN Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) CDH2 CDHN NCAD Homo sapiens (Human) adherens junction organization [GO:0034332]; blood vessel morphogenesis [GO:0048514]; brain morphogenesis [GO:0048854]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cerebral cortex development [GO:0021987]; detection of muscle stretch [GO:0035995]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homeostasis of number of cells [GO:0048872]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neural crest cell development [GO:0014032]; neuroepithelial cell differentiation [GO:0060563]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic vesicle clustering [GO:2000809]; protein localization to plasma membrane [GO:0072659]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; striated muscle cell differentiation [GO:0051146]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; type B pancreatic cell development [GO:0003323] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; endoplasmic reticulum lumen [GO:0005788]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723] VCQCDSNGDCTDVDR;VKVCQCDSNGDCTDVDR 2 1.9 0.71319 0.14425 0 3.74556 0 6.57272 0 0 0 0 0 5.80715 0 0 P19075 TSN8_HUMAN Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029) TSPAN8 TM4SF3 Homo sapiens (Human) negative regulation of blood coagulation [GO:0030195]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] integrin binding [GO:0005178] CMLLLFFIGLLLILLLQVATGILGAVFK 1 11.8 0.71456 0.14212 0 0 0 7.27622 0 0 0 0 0 0 0 0 P19086 GNAZ_HUMAN Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) GNAZ Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; negative regulation of insulin secretion [GO:0046676] cell body [GO:0044297]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; heterotrimeric G-protein complex [GO:0005834]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; synapse [GO:0045202] adenylate cyclase inhibitor activity [GO:0010855]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] ELTFKMVDVGGQRSER;QFEDLNRNKETK 2 7.9 0.88133 -0.17035 0 0 0 0 8.63963 0 0 0 0 8.24764 0 0 P19087 GNAT2_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) GNAT2 GNATC Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell morphogenesis [GO:0000902]; cone retinal bipolar cell differentiation [GO:1904390]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; L-glutamate import [GO:0051938]; neural tissue regeneration [GO:0097719]; phototransduction [GO:0007602]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein localization [GO:0008104]; reactive gliosis [GO:0150103]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; retinal cone cell development [GO:0046549]; retinal rod cell differentiation [GO:0060221]; tissue remodeling [GO:0048771]; visual behavior [GO:0007632]; visual perception [GO:0007601] cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] KDVKEIYSHMTCATDTQNVK;LLLLGAGESGK;TTGIIETKFSVKDLNFR 3 13.6 0.9591 -1.0407 12.7952 0 0 0 0 0 0 0 0 0 8.39339 0 P19099 C11B2_HUMAN "Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)" CYP11B2 Homo sapiens (Human) aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; potassium ion homeostasis [GO:0055075]; regulation of blood volume by renal aldosterone [GO:0002017]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; sterol metabolic process [GO:0016125] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507]; steroid hydroxylase activity [GO:0008395] ARALGTR 1 1.4 0.60328 0.17683 0 0 0 0 0 0 0 0 0 0 6.51622 0 P19113 DCHS_HUMAN Histidine decarboxylase (HDC) (EC 4.1.1.22) HDC Homo sapiens (Human) catecholamine biosynthetic process [GO:0042423]; histamine biosynthetic process [GO:0001694]; L-histidine catabolic process [GO:0006548]; L-histidine metabolic process [GO:0006547] cytoplasm [GO:0005737]; cytosol [GO:0005829] histidine decarboxylase activity [GO:0004398]; pyridoxal phosphate binding [GO:0030170] KNKILEMK;NLQAHVR;YFESLVR 3 3.3 0.9728 -1.3742 0 0 0 0 0 0 0 0 0 0 8.67193 0 P19174 PLCG1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)" PLCG1 PLC1 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; release of sequestered calcium ion into cytosol [GO:0051209]; T cell receptor signaling pathway [GO:0050852] cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971] GDYGGKK;IEGAIDIREIKEIRPGK;IGTERACYR;LGAGRDGR;LQLSRIYPKGQR;RNEPNSYAISFRAEGK 6 5.3 0.97479 -3.1158 0 0 10.8345 9.12099 8.11327 0 0 8.85891 10.9784 0 7.99532 0 P19235 EPOR_HUMAN Erythropoietin receptor (EPO-R) EPOR Homo sapiens (Human) brain development [GO:0007420]; cytokine-mediated signaling pathway [GO:0019221]; decidualization [GO:0046697]; erythropoietin-mediated signaling pathway [GO:0038162]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] erythropoietin receptor activity [GO:0004900]; identical protein binding [GO:0042802] ARPHVIYFCLLR 1 5 0.80433 0.012891 0 0 0 0 0 7.804 0 0 0 0 0 0 P19237 TNNI1_HUMAN "Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)" TNNI1 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; regulation of striated muscle contraction [GO:0006942]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cytosol [GO:0005829]; troponin complex [GO:0005861] actin binding [GO:0003779] AKECWEQEHEER;GLSLSALQDLCR;KEDTEKERPVEVGDWR 3 21.4 0.95222 -0.75407 0 0 0 8.02774 0 0 0 0 0 0 0 11.8834 P19256 LFA3_HUMAN Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58) CD58 LFA3 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; positive regulation of interleukin-8 production [GO:0032757] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] signaling receptor binding [GO:0005102] VAELENSEFR 1 4 0.89714 -0.23554 0 0 0 0 0 0 0 0 9.82942 0 0 0 P19320 VCAM1_HUMAN Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1] VCAM1 Homo sapiens (Human) amine metabolic process [GO:0009308]; B cell differentiation [GO:0030183]; cardiac neuron differentiation [GO:0060945]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chronic inflammatory response [GO:0002544]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; innervation [GO:0060384]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043] alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383] cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; primary methylamine oxidase activity [GO:0008131] LEIELLK 1 0.9 0.91475 -0.33057 0 0 0 0 5.53419 0 0 0 0 0 0 0 P19338 NUCL_HUMAN Nucleolin (Protein C23) NCL Homo sapiens (Human) "angiogenesis [GO:0001525]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of translation [GO:0017148]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]" cell cortex [GO:0005938]; chromosome [GO:0005694]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; macropinosome membrane [GO:0160056]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] DNA topoisomerase binding [GO:0044547]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; mRNA 5'-UTR binding [GO:0048027]; PH domain binding [GO:0042731]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] AAATPAK;AAATSAK;ALELTGLK;ALVATPGK;GFGFVDFNSEEDAK;GLSEDTTEETLKESFDGSVR;LELQGPR;NDLAVVDVR;NSTWSGESK;QGTEIDGR;SISLYYTGEK;TGISDVFAK;TGISDVFAKNDLAVVDVR;TLVLSNLSYSATEETLQEVFEK;VAVATPAK;VEGTEPTTAFNLFVGNLNFNK;VTLDWAKPK 17 24.8 0 77.396 14.7168 13.7263 14.6528 12.1478 11.3205 11.3085 13.6221 13.3353 13.248 11.3697 12.3393 13.2018 P19367 HXK1_HUMAN Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) HK1 Homo sapiens (Human) canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose biosynthetic process from glucose [GO:0141199]; GDP-mannose biosynthetic process from mannose [GO:0061728]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731] cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834] EGLLFEGRITPELLTRGK;EIDRGSLNPGK;ELSPKCNVSFLLSEDGSGK;ITPELLTR;LVDEYSLNAGKQRYEK;MGQICQRESATAAEKPK;TTVGVDGSLYK;VQVNHEK 8 10.7 0.97631 -5.0151 12.4864 0 0 0 0 11.2967 7.2035 0 0 0 0 7.09149 P19387 RPB3_HUMAN DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31) POLR2C A-152E5.7 Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983] MPYANQPTVR 1 3.6 0.89697 -0.23554 0 0 0 0 0 0 0 0 9.64017 0 0 0 P19388 RPAB1_HUMAN "DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)" POLR2E Homo sapiens (Human) protein stabilization [GO:0050821]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; tRNA transcription by RNA polymerase III [GO:0042797] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] QSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTK;TIMQLCHDR 2 22.4 0.92862 -0.4638 0 0 0 6.00282 0 0 0 0 0 0 9.94974 0 P19404 NDUV2_HUMAN "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)" NDUFV2 Homo sapiens (Human) "aerobic respiration [GO:0009060]; cardiac muscle tissue development [GO:0048738]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] "2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" AAAVLPVLDLAQR 1 5.2 0.93682 -0.55365 0 0 0 0 0 0 0 0 0 0 0 8.99331 P19429 TNNI3_HUMAN "Troponin I, cardiac muscle (Cardiac troponin I)" TNNI3 TNNC1 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; heart contraction [GO:0060047]; heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of ATP-dependent activity [GO:0032780]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of smooth muscle contraction [GO:0006940]; regulation of systemic arterial blood pressure by ischemic conditions [GO:0001980]; skeletal muscle contraction [GO:0003009]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; troponin complex [GO:0005861] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; calcium-dependent protein binding [GO:0048306]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; troponin C binding [GO:0030172]; troponin T binding [GO:0031014] ADGSSDAAR;EAEERRGEK;NIDALSGMEGRK 3 14.3 0.98003 -1.8197 0 0 0 0 0 0 0 0 0 0 0 9.88131 P19438 TNR1A_HUMAN "Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]" TNFRSF1A TNFAR TNFR1 Homo sapiens (Human) aortic valve development [GO:0003176]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to mechanical stimulus [GO:0071260]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of inflammatory response [GO:0050728]; positive regulation of amide metabolic process [GO:0034250]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lipid metabolic process [GO:0045834]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostaglandin metabolic process [GO:0006693]; protein localization to plasma membrane [GO:0072659]; pulmonary valve development [GO:0003177]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of membrane lipid metabolic process [GO:1905038]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947] signaling receptor activity [GO:0038023]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031] ENECVSCSNCK;ENECVSCSNCKK;LYSIVCGK 3 4.4 0.93383 -0.49841 6.30921 0 0 0 0 0 0 0 0 0 0 5.63291 P19447 ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ERCC3 XPB XPBC Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; embryonic organ development [GO:0048568]; hair cell differentiation [GO:0035315]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]" nucleoplasm [GO:0005654]; nucleotide-excision repair factor 3 complex [GO:0000112]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; promoter-specific chromatin binding [GO:1990841]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FGTMSSMSGADDTVYMEYHSSR;FHERRNDK;LNKPYIYGPTSQGERMQILQNFK;SGVIVLPCGAGK 4 8.3 0.95867 -1.0101 0 0 0 0 0 0 0 9.11917 5.07703 7.36938 0 0 P19474 RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) TRIM21 RNF81 RO52 SSA1 Homo sapiens (Human) cellular response to chemical stress [GO:0062197]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein binding [GO:0032092]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; pyroptotic inflammatory response [GO:0070269]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of type I interferon production [GO:0032479]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; stress granule disassembly [GO:0035617]; suppression of viral release by host [GO:0044790] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ALCWVCAQSR 1 2.1 0.89555 -0.24377 0 0 0 0 0 0 8.66302 0 0 0 0 0 P19484 TFEB_HUMAN Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) TFEB BHLHE35 Homo sapiens (Human) adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; embryonic placenta development [GO:0001892]; humoral immune response [GO:0006959]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of lysosome organization [GO:1905671]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GTILKASVDYIRR;LEMTNKQLWLR 2 5 0.96571 -1.1315 0 6.46374 0 0 0 0 0 0 0 12.464 0 0 P19525 E2AK2_HUMAN "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)" EIF2AK2 PKR PRKR Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; defense response to virus [GO:0051607]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation [GO:0006446]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein phosphatase regulator activity [GO:0019888]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] CLFIQMEFCDK;KSPEKNER;RSLAPRFDLPDMK;TLLQKLLSKKPEDRPNTSEILR 4 9.8 0.95578 -0.8412 0 13.5723 0 10.5057 10.2473 10.0735 7.54928 0 0 0 6.52441 0 P19532 TFE3_HUMAN Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) TFE3 BHLHE33 Homo sapiens (Human) adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" VQTHLENPTRYHLQQAR;YHLQQARR 2 3.1 0.95425 -0.88689 0 9.86536 0 9.7491 0 0 0 0 0 0 0 0 P19532 TFE3_HUMAN Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) TFE3 BHLHE33 Homo sapiens (Human) adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" SQPLPLRSR 1 8.3 0.97364 -1.3781 0 0 0 0 0 0 0 0 0 0 8.71805 0 P19544 WT1_HUMAN Wilms tumor protein (WT33) WT1 Homo sapiens (Human) adrenal cortex formation [GO:0035802]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to cAMP [GO:0071320]; cellular response to gonadotropin stimulus [GO:0071371]; diaphragm development [GO:0060539]; epithelial cell differentiation [GO:0030855]; germ cell development [GO:0007281]; glomerular basement membrane development [GO:0032836]; glomerulus development [GO:0032835]; gonad development [GO:0008406]; heart development [GO:0007507]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric epithelium development [GO:0072207]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of female gonad development [GO:2000195]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of metanephric glomerular mesangial cell proliferation [GO:0072302]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; podocyte differentiation [GO:0072112]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of heart growth [GO:0060421]; positive regulation of male gonad development [GO:2000020]; positive regulation of metanephric ureteric bud development [GO:2001076]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; regulation of animal organ formation [GO:0003156]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sex determination [GO:0007530]; thorax and anterior abdomen determination [GO:0007356]; tissue development [GO:0009888]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; visceral serous pericardium development [GO:0061032] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "C2H2 zinc finger domain binding [GO:0070742]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" RHTGVKPFQCK;RSRGASGSEPQQMGSDVR 2 5.6 0.77061 0.054414 0 0 0 0 0 10.0203 10.7589 0 0 0 0 0 P19622 HME2_HUMAN Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2) EN2 Homo sapiens (Human) dopaminergic neuron differentiation [GO:0071542]; embryonic brain development [GO:1990403]; hindbrain development [GO:0030902]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ITNFFIDNILRPEFGR;RPRTAFTAEQLQRLK 2 9.3 0.84136 -0.048808 11.0915 0 0 0 0 0 4.49978 0 0 0 0 0 P19623 SPEE_HUMAN Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) SRM SPS1 SRML1 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766] MEPGPDGPAASGPAAIR;YYNSDVHRAAFVLPEFARK 2 11.9 0.0047393 1.47 0 9.48424 0 0 0 0 0 0 0 0 0 0 P19634 SL9A1_HUMAN "Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)" SLC9A1 APNH1 NHE1 Homo sapiens (Human) cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell differentiation [GO:0055007]; cell migration [GO:0016477]; cellular response to acidic pH [GO:0071468]; cellular response to antibiotic [GO:0071236]; cellular response to cold [GO:0070417]; cellular response to electrical stimulus [GO:0071257]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of cell polarity [GO:0030011]; monoatomic ion transport [GO:0006811]; negative regulation of apoptotic process [GO:0043066]; positive regulation of action potential [GO:0045760]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein complex oligomerization [GO:0051259]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of focal adhesion assembly [GO:0051893]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; regulation of stress fiber assembly [GO:0051492]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; response to acidic pH [GO:0010447]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; stem cell differentiation [GO:0048863] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cation-transporting ATPase complex [GO:0090533]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; T-tubule [GO:0030315] "calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; potassium:proton antiporter activity [GO:0015386]; protein phosphatase 2B binding [GO:0030346]; protein-macromolecule adaptor activity [GO:0030674]; sodium:proton antiporter activity [GO:0015385]" IFPSLLVVVALVGLLPVLR;IGSDPLAYEPK;LDSPTMSRAR 3 4.9 0.96471 -1.2333 0 4.56791 0 0 0 2.50016 0 4.05441 0 9.35999 0 0 P19652 A1AG2_HUMAN Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2) ORM2 AGP2 Homo sapiens (Human) acute-phase response [GO:0006953]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682] azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580] SDVMYTDWK;TLMFGSYLDDEK 2 10.4 0.93598 -0.54634 0 0 0 0 0 4.71298 0 0 6.41495 10.9625 11.0349 0 P19784 CSK22_HUMAN Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) CSNK2A2 CK2A2 Homo sapiens (Human) apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; liver regeneration [GO:0097421]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of chromosome separation [GO:1905818]; regulation of mitophagy [GO:1901524]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] acrosomal vesicle [GO:0001669]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALDYCHSKGIMHR;GGTNIIK;ILKPVKKK;VVVKILKPVK;VVVKILKPVKK 5 9.1 0.90035 -0.25908 8.46299 7.774 0 0 0 0 0 7.23688 0 8.98786 2.91783 0 P19801 AOC1_HUMAN Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) (KDAO) AOC1 ABP ABP1 DAO Homo sapiens (Human) amine metabolic process [GO:0009308]; putrescine metabolic process [GO:0009445] bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; primary methylamine oxidase activity [GO:0008131]; protein homodimerization activity [GO:0042803]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038] KAGVFSDLSNQELK;LVQPHGPR 2 2.9 0.88968 -0.20463 10.9112 10.3888 0 0 0 0 0 0 0 0 0 0 P19823 ITIH2_HUMAN Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH2 IGHEP2 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] endopeptidase inhibitor activity [GO:0004866]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867] FYNQVSTPLLR;GAFISNFSMTVDGK;IQPSGGTNINEALLR;NICFNIDSEPGK;VWKKHPVNVDFLGIYIPPTNK 5 7.7 0.0047847 1.5178 10.3611 12.5614 12.704 11.0548 10.5926 8.78077 0 9.61471 0 11.1568 11.2318 0 P19827 ITIH1_HUMAN Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH1 IGHEP1 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867] AAISGENAGLVR;IADNKQSSFK;LWAYLTIQELLAKRMK;RNHMQYEIVIK;VTSRFAHYVVTSQVVNTANEAR 5 7.8 0.9749 -3.7176 0 7.60837 0 0 11.2514 0 7.97137 11.9362 0 11.177 11.2899 0 P19838 NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Homo sapiens (Human) antibacterial innate immune response [GO:0140367]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-17 [GO:0097398]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; mammary gland involution [GO:0060056]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; I-kappaB/NF-kappaB complex [GO:0033256]; mitochondrion [GO:0005739]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; transcription regulator complex [GO:0005667] "actinin binding [GO:0042805]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein sequestering activity [GO:0140311]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]" DPEGCDKSDDK;QAALQQTK;SYPQVKICNYVGPAK 3 3.5 0.97474 -1.3856 0 0 0 0 5.7575 0 0 0 0 8.42038 0 0 P19875 CXCL2_HUMAN C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)] CXCL2 GRO2 GROB MIP2A SCYB2 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; response to molecule of bacterial origin [GO:0002237] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236] LLRVALLLLLLVAASR;VALLLLLLVAASRR;VALLLLLLVAASRRAAGAPLATELR 3 26.2 0.66647 0.16893 0 2.46785 0 0 0 5.37841 0 0 0 0 0 0 P19876 CXCL3_HUMAN C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)] CXCL3 GRO3 GROG SCYB3 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236] LLRVALLLLLLVAASR;MAHATLSAAPSNPRLLRVALLLLLLVAASR;VALLLLLLVAASRR 3 29 0.27913 0.2539 7.09782 0 0 0 0 4.04579 0 3.54523 0 0 0 7.72192 P19878 NCF2_HUMAN Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) NCF2 NOXA2 P67PHOX Homo sapiens (Human) cellular defense response [GO:0006968]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886] electron transfer activity [GO:0009055]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176] LSVPMPYTLKVHYK 1 2.7 0.94486 -0.64549 0 0 0 0 0 0 0 0 0 0 0 11.7351 P19957 ELAF_HUMAN Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14) PI3 WAP3 WFDC14 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; copulation [GO:0007620]; innate immune response [GO:0045087]; peptide cross-linking [GO:0018149] cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; structural constituent of skin epidermis [GO:0030280] CCEGSCGMACFVPQ 1 12 0.80223 0.014243 0 0 0 0 0 0 5.90501 0 0 0 0 0 P19971 TYPH_HUMAN Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) TYMP ECGF1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969] cytosol [GO:0005829] "1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; thymidine phosphorylase activity [GO:0009032]" QLPELIRMK 1 1.9 0.97563 -1.4333 0 0 0 0 0 0 0 0 0 0 0 10.4163 P20020 AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) ATP2B1 PMCA1 Homo sapiens (Human) calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport [GO:0051928]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of vascular associated smooth muscle contraction [GO:0003056] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; P-type calcium transporter activity [GO:0005388] MVTGDNINTAR;NSDGSYR 2 1.5 0.94149 -0.60278 0 0 9.7857 0 0 0 0 0 0 0 0 0 P20036 DPA1_HUMAN "HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)" HLA-DPA1 HLA-DP1A HLASB Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to type II interferon [GO:0071346]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729] cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] AVILRALSLAFLLSLR;AVILRALSLAFLLSLRGAGAIK 2 8.5 0.96588 -1.1306 0 0 0 0 5.44311 0 7.61213 0 0 0 0 6.81211 P20042 IF2B_HUMAN Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) EIF2S2 EIF2B Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; synapse [GO:0045202] "metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]" EVEPEPTEDK;IFDIDEAEEGVK;SPDTILQK;TGFQAVTGK 4 11.7 0.91598 -0.34505 0 0 0 0 0 3.158 0 0 0 12.3754 0 0 P20061 TCO1_HUMAN Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI) TCN1 TC1 Homo sapiens (Human) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; molecular sequestering activity [GO:0140313] LVGIQIQTLMQKMIQQIKYNVK 1 5.1 0.55933 0.18276 0 0 0 8.43133 0 0 0 0 0 0 0 0 P20062 TCO2_HUMAN Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII) TCN2 TC2 Homo sapiens (Human) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; metal ion binding [GO:0046872] EDLYLHSLK;RVHDSVVDK 2 4.5 0.91463 -0.3802 0 0 0 0 0 0 0 0 0 10.0725 0 0 P20073 ANXA7_HUMAN Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 SNX OK/SW-cl.95 Homo sapiens (Human) autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; negative regulation of gene expression [GO:0010629] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; phosphatidylserine binding [GO:0001786]; RNA binding [GO:0003723] EFSGYVESGLK;EIVRCYQSEFGRDLEK;GAGTDDSTLVR;GAGTDDSTLVRIVVTR;LYQAGEGR 5 10.5 0.96473 -1.169 0 0 9.26814 0 8.14598 0 0 0 0 10.7763 0 7.54867 P20138 CD33_HUMAN Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) CD33 SIGLEC3 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; Fc-gamma receptor signaling pathway [GO:0038094]; immune response-inhibiting signal transduction [GO:0002765]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of monocyte activation [GO:0150102]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of protein secretion [GO:0050714]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activator activity [GO:0008160]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023] NSPVHGYWFR 1 2.7 0.92601 -0.4531 0 0 0 0 0 0 10.7752 0 0 0 0 0 P20142 PEPC_HUMAN Gastricsin (EC 3.4.23.3) (Pepsinogen C) PGC Homo sapiens (Human) digestion [GO:0007586]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508] extracellular space [GO:0005615] aspartic-type endopeptidase activity [GO:0004190] VGFATAA;WMVVVLVCLQLLEAAVVK 2 6.4 0.55378 0.18317 0 0 0 8.61055 0 0 0 0 0 10.3077 0 9.87478 P20231 TRYB2_HUMAN Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II) TPSB2 TPS2 Homo sapiens (Human) proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] VGIVGGQEAPR 1 4 0.89834 -0.23383 0 0 0 0 0 0 0 0 0 9.39988 0 0 P20248 CCNA2_HUMAN Cyclin-A2 (Cyclin-A) (Cyclin A) CCNA2 CCN1 CCNA Homo sapiens (Human) animal organ regeneration [GO:0031100]; cell cycle G1/S phase transition [GO:0044843]; cell division [GO:0051301]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to leptin stimulus [GO:0044320]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to nitric oxide [GO:0071732]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cochlea development [GO:0090102]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; post-translational protein modification [GO:0043687]; Ras protein signal transduction [GO:0007265]; regulation of DNA replication [GO:0006275]; response to glucagon [GO:0033762] cyclin A2-CDK1 complex [GO:0097122]; cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] AALAVLK;AAPVQQPR;EAQKKPAESQK;LGNSAPGPATR;QPAFTIHVDEAEK 5 11.6 0.97495 -1.3921 0 0 0 9.37832 9.04751 0 0 11.5423 0 11.5399 12.0128 0 P20273 CD22_HUMAN B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) B cell activation [GO:0042113]; cell adhesion [GO:0007155]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of immunoglobulin production [GO:0002638]; regulation of B cell proliferation [GO:0030888]; regulation of endocytosis [GO:0030100]; regulation of immune response [GO:0050776] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] carbohydrate binding [GO:0030246]; CD4 receptor binding [GO:0042609]; IgM binding [GO:0001791]; protein phosphatase binding [GO:0019903]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102] EVQFFWEK;IVTCQLQDADGKFLSNDTVQLNVKHTPK;LYESTKDGK;TEKWMER 4 6.1 0.97678 -2.281 0 12.2038 0 10.4269 0 0 0 0 9.91941 0 11.7501 0 P20290 BTF3_HUMAN Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) BTF3 NACB OK/SW-cl.8 Homo sapiens (Human) in utero embryonic development [GO:0001701]; negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] RNA binding [GO:0003723] GQEPQMK;LAEALPK;VQASLAANTFTITGHAETK 3 16 0.0085288 0.97651 13.4486 11.6074 11.6643 9.70408 9.49653 0 0 0 0 0 11.3782 10.998 P20309 ACM3_HUMAN Muscarinic acetylcholine receptor M3 CHRM3 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; calcium-mediated signaling [GO:0019722]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; positive regulation of smooth muscle contraction [GO:0045987]; protein modification process [GO:0036211]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of smooth muscle contraction [GO:0006940]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]" basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; G protein-coupled acetylcholine receptor activity [GO:0016907]; phosphatidylinositol phospholipase C activity [GO:0004435]; signaling receptor activity [GO:0038023] MLLLCQCDKK 1 1.7 0.39216 0.21351 0 0 0 0 0 0 0 0 0 0 0 7.14496 P20336 RAB3A_HUMAN Ras-related protein Rab-3A RAB3A Homo sapiens (Human) acrosomal vesicle exocytosis [GO:0060478]; axonogenesis [GO:0007409]; constitutive secretory pathway [GO:0045054]; evoked neurotransmitter secretion [GO:0061670]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; lung development [GO:0030324]; lysosome localization [GO:0032418]; maintenance of presynaptic active zone structure [GO:0048790]; mitochondrion organization [GO:0007005]; neuromuscular synaptic transmission [GO:0007274]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; post-embryonic development [GO:0009791]; regulated exocytosis [GO:0045055]; regulation of plasma membrane repair [GO:1905684]; regulation of presynaptic dense core granule exocytosis [GO:0099161]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; respiratory system process [GO:0003016]; response to electrical stimulus [GO:0051602]; sensory perception of touch [GO:0050975]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle transport [GO:0048489] acrosomal vesicle [GO:0001669]; axon [GO:0030424]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein-macromolecule adaptor activity [GO:0030674] DNINVKQTFER;TIYRNDKR;VVSSERGR 3 12.3 0.9749 -3.1608 0 0 0 0 0 0 0 0 0 10.5686 0 0 P20338 RAB4A_HUMAN Ras-related protein Rab-4A (EC 3.6.5.2) RAB4A RAB4 Homo sapiens (Human) antigen processing and presentation [GO:0019882]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192]; vesicle-mediated transport in synapse [GO:0099003] cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; vesicle [GO:0031982] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] IINVGGK;RAQAPNAQECGC 2 8.7 0.91618 -0.37507 0 0 0 0 0 0 0 0 0 4.56395 0 0 P20339 RAB5A_HUMAN Ras-related protein Rab-5A (EC 3.6.5.2) RAB5A RAB5 Homo sapiens (Human) amyloid-beta clearance by transcytosis [GO:0150093]; canonical Wnt signaling pathway [GO:0060070]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; modulation by host of viral process [GO:0044788]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; receptor internalization [GO:0031623]; regulation of autophagosome assembly [GO:2000785]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endomembrane system [GO:0012505]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; somatodendritic compartment [GO:0036477]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] GQFHEFQESTIGVK;LVLLGESAVGK;QASPNIVIALSGNK 3 19.4 0.94084 -0.60872 0 11.5821 0 0 0 0 0 0 0 8.35456 0 0 P20393 NR1D1_HUMAN Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) NR1D1 EAR1 HREV THRAL Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:0005978]; hormone-mediated signaling pathway [GO:0009755]; intracellular glucose homeostasis [GO:0001678]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasomal protein catabolic process [GO:0010498]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of fat cell differentiation [GO:0045598]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of lipid metabolic process [GO:0019216]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to leptin [GO:0044321] chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; heme binding [GO:0020037]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" APANSPR;EIFTYAHDK;LLLKLPDLR 3 4.1 0.96434 -1.1713 0 0 12.0516 0 0 0 4.80977 11.3378 0 8.1115 0 0 P20396 TRH_HUMAN Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)] TRH Homo sapiens (Human) adult walking behavior [GO:0007628]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; histamine metabolic process [GO:0001692]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of glutamate secretion [GO:0014050]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of insulin secretion [GO:0032024]; signal transduction [GO:0007165] extracellular region [GO:0005576]; secretory granule [GO:0030141] thyrotropin-releasing hormone activity [GO:0008437] EEEEEEGVEEEEEEEGGAVGPHK 1 9.5 0.70198 0.16126 0 0 0 0 0 0 7.7037 0 0 0 0 0 P20472 PRVA_HUMAN Parvalbumin alpha PVALB Homo sapiens (Human) excitatory chemical synaptic transmission [GO:0098976]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977] axon [GO:0030424]; cytoplasm [GO:0005737]; synapse [GO:0045202] calcium ion binding [GO:0005509] KAVGAFSATDSFDHK 1 13.6 0.92851 -0.47053 0 0 0 8.74594 0 0 0 0 0 0 0 0 P20585 MSH3_HUMAN DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; somatic recombination of immunoglobulin gene segments [GO:0016447] membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983] ATSQSLVILDELGR;ENVRDKK;QTETAALK;VQTESLQER;YRFFGEDAEIAAR 5 4.5 0.97301 -2.6288 0 0 8.13391 0 0 5.40511 9.28385 10.966 11.0515 0 0 6.59376 P20591 MX1_HUMAN "Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]" MX1 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] ELEEEKK;LHFQMEQIVYCQDQVYR;LVNEDKWRGK;NFEEFFNLHRTAK 4 7.1 0.97637 -1.4869 0 0 10.765 0 0 0 0 0 0 10.8934 0 0 P20592 MX2_HUMAN Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein) MX2 Homo sapiens (Human) defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear pore [GO:0005643]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] GKELLGFVNYK 1 1.5 0.97912 -1.5411 0 0 0 0 0 0 0 0 10.5545 0 0 0 P20592 MX2_HUMAN Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein) MX2 Homo sapiens (Human) defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear pore [GO:0005643]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] DIGLQVS 1 3.5 0.92448 -0.45018 0 0 0 0 0 0 0 8.6418 0 0 0 0 P20594 ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB Homo sapiens (Human) activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872] cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672] LVEERTQAYLEEKR 1 1.3 0.76434 0.062645 0 0 0 8.29724 0 7.75742 0 0 0 0 0 0 P20618 PSB1_HUMAN Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) PSMB1 PSC5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]" DVYTGDALR 1 3.7 0.81316 -0.010245 10.7839 0 11.0709 0 0 0 0 0 0 0 0 0 P20645 MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6PR MPR46 MPRD Homo sapiens (Human) endosome to lysosome transport [GO:0008333]; glycosphingolipid catabolic process [GO:0046479]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; secretion of lysosomal enzymes [GO:0033299] clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] protein domain specific binding [GO:0019904]; protein transporter activity [GO:0140318]; retromer complex binding [GO:1905394]; transmembrane signaling receptor activity [GO:0004888] HTLADNFNPVSEER 1 5.1 0.94031 -0.58478 0 0 0 0 0 0 0 0 0 0 11.6856 0 P20648 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) ATP4A Homo sapiens (Human) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transmembrane transport [GO:0034220]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of proton transport [GO:0010155]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376] apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; potassium ion binding [GO:0030955] ADIGVAMGIAGSDAAK;TGTLTQNR;VIMVTGDHPITAK;VLGFCQLYLNEK 4 4.7 0.94114 -0.60764 0 0 0 0 0 0 0 9.94607 0 0 0 0 P20674 COX5A_HUMAN "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" COX5A Homo sapiens (Human) "cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] IIDAALR;IIDAALRACRR;LNDFASTVR;WVTYFNKPDIDAWELR 4 24 0.23691 0.29106 11.437 0 12.4594 0 0 0 10.0947 0 0 0 10.1659 0 P20700 LMNB1_HUMAN Lamin-B1 LMNB1 LMN2 LMNB Homo sapiens (Human) heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435] lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phospholipase binding [GO:0043274]; sequence-specific double-stranded DNA binding [GO:1990837]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of nuclear lamina [GO:0160123] AGGPTTPLSPTR;ALDDTAR;ALYETELADAR;ATATPVPPR;DNSRRMLTDK;IQELEDLLAK;LLEGEEER;LSPSPSSR;LSSEMNTSTVNSAR;LYKEELEQTYHAK;NSQGEEVAQR 11 19.1 0 6.7521 12.6692 12.3522 13.577 3.33614 10.7347 0 11.0394 0 9.20992 12.8836 12.0337 0 P20701 ITAL_HUMAN Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) ITGAL CD11A Homo sapiens (Human) cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; phagocytosis [GO:0006909]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; integrin alphaL-beta2 complex [GO:0034687]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] cell adhesion molecule binding [GO:0050839]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] GLFPGGR 1 0.6 0.68914 0.16248 0 0 0 0 0 10.3904 0 0 0 0 0 0 P20711 DDC_HUMAN Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) DDC AADC Homo sapiens (Human) amino acid metabolic process [GO:0006520]; carboxylic acid metabolic process [GO:0019752]; catecholamine metabolic process [GO:0006584]; dopamine biosynthetic process [GO:0042416]; gene expression [GO:0010467]; kidney development [GO:0001822]; response to toxic substance [GO:0009636]; serotonin biosynthetic process [GO:0042427] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] 5-hydroxy-L-tryptophan decarboxylase activity [GO:0036467]; aromatic-L-amino-acid decarboxylase activity [GO:0004058]; enzyme binding [GO:0019899]; L-dopa decarboxylase activity [GO:0036468]; pyridoxal phosphate binding [GO:0030170] FEICVEVILGLVCFRLKGSNK;MWFVFRMYGVKGLQAYIR 2 10.1 0.27506 0.25459 0 10.4592 7.51001 0 0 0 0 0 0 0 0 0 P20718 GRAH_HUMAN Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C) GZMH CGL2 CTSGL2 Homo sapiens (Human) apoptotic process [GO:0006915]; killing of cells of another organism [GO:0031640]; protein maturation [GO:0051604]; proteolysis [GO:0006508] cytolytic granule [GO:0044194]; extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ATEICVGDPKK 1 4.5 0.91754 -0.40017 0 0 0 0 9.50259 0 0 0 0 0 0 0 P20742 PZP_HUMAN Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) female pregnancy [GO:0007565] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] AEGIEQEK;ATVLNYLPK;MVSGFIPLKPTVK;QNQNREILNSLDKEAVK;SESYRRTTFPVR 5 4.7 0.96759 -1.2968 0 8.47974 0 0 0 0 0 8.07831 0 12.3735 0 0 P20774 MIME_HUMAN Mimecan (Osteoglycin) (Osteoinductive factor) (OIF) OGN OIF SLRR3A Homo sapiens (Human) articular cartilage development [GO:0061975]; bone development [GO:0060348]; negative regulation of smooth muscle cell proliferation [GO:0048662] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] growth factor activity [GO:0008083] TLQSTLLLLLLVPLIKPAPPTQQDSR 1 8.7 0.71228 0.14778 0 5.7021 0 0 0 0 0 0 0 0 0 0 P20783 NTF3_HUMAN Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor) NTF3 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor internalization [GO:0002092]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102] ENYQSTLPK;GIDDKHWNSQCK;GIQGNNMDQR;LVGWRWIR 4 15.2 0.97415 -3.7912 0 0 12.5229 0 8.2407 0 0 0 0 8.71036 10.0074 9.71646 P20794 MAK_HUMAN Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) MAK Homo sapiens (Human) cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary transport [GO:0042073]; negative regulation of non-motile cilium assembly [GO:1902856]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription coactivator activity [GO:0003713] ENLYQLMK;EVQSAGQRIHLAPLNATASEYTWNTKTGR;FYSWDECMNLREVKSLK;LNHANVIKLKEVIR 4 10.9 0.97109 -1.3424 0 2.32691 0 9.44993 0 0 0 0 0 0 0 12.4682 P20800 EDN2_HUMAN Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2) EDN2 Homo sapiens (Human) angiogenesis [GO:0001525]; artery smooth muscle contraction [GO:0014824]; axon extension [GO:0048675]; cell surface receptor signaling pathway [GO:0007166]; cell tip growth [GO:0009932]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; hormonal regulation of the force of heart contraction [GO:0003058]; intracellular calcium ion homeostasis [GO:0006874]; lung alveolus development [GO:0048286]; macrophage activation [GO:0042116]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of heart rate [GO:0010460]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of the force of heart contraction by chemical signal [GO:0003099]; prostaglandin biosynthetic process [GO:0001516]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; temperature homeostasis [GO:0001659]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826] extracellular region [GO:0005576]; extracellular space [GO:0005615] endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179] VSVPTTWCSVALALLVALHEGK 1 12.4 0.67811 0.1655 0 0 0 0 0 0 0 5.52782 0 0 0 0 P20807 CAN3_HUMAN Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) CAPN3 CANP3 CANPL3 NCL1 Homo sapiens (Human) apoptotic process [GO:0006915]; calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of catalytic activity [GO:0050790]; regulation of myoblast differentiation [GO:0045661]; response to calcium ion [GO:0051592]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; self proteolysis [GO:0097264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; myofibril [GO:0030016]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T-tubule [GO:0030315]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; catalytic activity [GO:0003824]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; ligase regulator activity [GO:0055103]; molecular adaptor activity [GO:0060090]; peptidase activity [GO:0008233]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432] FPIQFVWKRPPEICENPR;GSDERPTRTIIPVQYETR;MVRNMDNSLLQDSDLDPR;TIIPVQYETRMACGLVR;VLNTVVNKHKDLK 5 9 0.67088 0.16743 0 0 0 6.88264 0 0 12.7823 12.5164 10.7358 4.92908 0 0 P20809 IL11_HUMAN Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) IL11 Homo sapiens (Human) B cell differentiation [GO:0030183]; cell population proliferation [GO:0008283]; fat cell differentiation [GO:0045444]; interleukin-11-mediated signaling pathway [GO:0038154]; megakaryocyte differentiation [GO:0030219]; negative regulation of hormone secretion [GO:0046888]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-11 receptor binding [GO:0005142] SLLADTR 1 3.5 0.91106 -0.3201 8.75449 0 0 0 0 0 0 0 7.99927 0 0 0 P20810 ICAL_HUMAN Calpastatin (Calpain inhibitor) (Sperm BS-17 component) CAST Homo sapiens (Human) inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; presynaptic active zone organization [GO:1990709] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] cadherin binding [GO:0045296]; calcium-dependent cysteine-type endopeptidase inhibitor activity [GO:0010859]; endopeptidase inhibitor activity [GO:0004866]; RNA binding [GO:0003723] AASLGSSQSSR;EVTIPPKYRELLAK;LAAAISEVVSQTPASTTQAGAPPR;LGERDDTIPPEYR;SLTPAVPVESKPDKPSGK;SQPGQKPAASPRPRRAAAAR;TEKEESTEVLK;TYAGGTASATK 8 16.3 0.97485 -3.7442 14.6109 0 0 10.1402 8.16937 0 0 8.27729 0 0 10.2662 10.7025 P20813 CP2B6_HUMAN "Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)" CYP2B6 Homo sapiens (Human) epoxygenase P450 pathway [GO:0019373]; ketone metabolic process [GO:0042180]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonate epoxygenase activity [GO:0008392]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 16-alpha-hydroxylase activity [GO:0008390]; testosterone 16-beta-hydroxylase activity [GO:0062184]" AEAFSGR;AEAFSGRGK;ELSVLLFLALLTGLLLLLVQR;IAMVDPFFR;MELSVLLFLALLTGLLLLLVQR;YGFLLMLKYPHVAERVYR 6 11.8 0.97606 -1.4529 11.5954 7.49761 11.7972 0 0 9.10622 7.95064 7.31325 0 0 9.33865 10.3845 P20823 HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) HNF1A TCF1 Homo sapiens (Human) D-glucose import [GO:0046323]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; liver development [GO:0001889]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; renal D-glucose absorption [GO:0035623] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" GESCGGGR;VYNWFANRR 2 2.7 0.91408 -0.39033 0 0 0 0 4.8939 0 0 0 0 0 0 0 P20827 EFNA1_HUMAN "Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]" EFNA1 EPLG1 LERK1 TNFAIP4 Homo sapiens (Human) angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; ephrin receptor signaling pathway [GO:0048013]; mitral valve morphogenesis [GO:0003183]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord formation [GO:0014028]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of axonogenesis [GO:0050770]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; substrate adhesion-dependent cell spreading [GO:0034446] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875]; signaling receptor binding [GO:0005102] LFPLAWTVLLLPLLLLQTP 1 9.3 0.78409 0.021107 0 0 0 0 0 9.49975 0 0 0 0 0 0 P20839 IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) IMPDH1 IMPD1 Homo sapiens (Human) GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] DYPLASK;EANEILQR;EANEILQRSK;YFSEGDK 4 4.7 0.94096 -0.58959 0 9.14522 0 0 0 0 0 0 0 0 0 0 P20908 CO5A1_HUMAN Collagen alpha-1(V) chain COL5A1 Homo sapiens (Human) "blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; eye morphogenesis [GO:0048592]; heart morphogenesis [GO:0003007]; integrin biosynthetic process [GO:0045112]; negative regulation of endodermal cell differentiation [GO:1903225]; regulation of cellular component organization [GO:0051128]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tendon development [GO:0035989]; wound healing, spreading of epidermal cells [GO:0035313]" basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; proteoglycan binding [GO:0043394] EGPPGEK;GETGFQGK;GLPGPQGSSGPK;SSKGPDVAYRVTK 4 2.2 0.97307 -2.5304 0 0 0 0 0 0 9.11905 11.6579 0 0 0 0 P20929 NEBU_HUMAN Nebulin NEB Homo sapiens (Human) cardiac muscle thin filament assembly [GO:0071691]; muscle organ development [GO:0007517]; regulation of actin filament length [GO:0030832]; somatic muscle development [GO:0007525] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Z disc [GO:0030018] actin filament binding [GO:0051015]; structural constituent of muscle [GO:0008307] ADYEQRK;AEHVKQKGHYVGVPTMR;AEYEEDRGKGFFPQTITQEYEAIK;AKSINYCETPKFK;AMYDYMAADADEVSFK;CHIPADAPQFIQHR;DGYRKQLGHHIGAR;DIASDYKYK;EDYENKIK;ENVGKATATPVTPEMQRVK;EYKKEFQK;FSSPVDMLSILLAK;GIGWVPIDSLEVVR;GLGWSPAGSLEVEK;GYDMRVDAIPIK;HLIHKYILLPDAMNIELTRNMNR;IMCAIHAGKIQSER;IMWSLHIAKVQSDR;INSVNQSDVKYK;KVQDQLSEVKYR;LGWEEALKK;LQSQYLYVELATK;LSSQVKYRENFDK;LVHFMQVAK;LVLSMNVAKMQSER;LYQEAWNK;NATQILNEKEYK;NFSLLQYQCDLKNSKGK;NIASDCK;NIASDYKYK;NTVLALRNTLIESDLK;QASEVEYRAKHR;QAWEADK;QNKVNYSEKLYK;QRPETLK;QSGEILDDIK;RNQENFSSILYK;SDAIPIVAAKASRDIASDYK;SIPDRPEHFHHR;SMNYCETPK;SREQSRSASALSISGGEEK;TLYSKYKYK;TSLRTLPTGYRLPGDTPHFK;VIGEFPGVVHCLDFQKMR;VKQTQDHISSVK;VNALNMSDAHYKADWKK;VNNVTSERLYRELYHK;VTDDISK;VVEMEQKR;YKDGYRK;YQEDFENMK 51 8.2 0.97891 -18.776 14.3272 12.022 10.8732 9.90492 11.1625 9.56564 11.8833 13.0723 9.48653 12.2226 12.3027 12.6562 P20930 FILA_HUMAN Filaggrin FLG Homo sapiens (Human) establishment of skin barrier [GO:0061436]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149] collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; structural constituent of skin epidermis [GO:0030280]; transition metal ion binding [GO:0046914] QSGTRHTESSSR;RLSERLEEK;SASRKTYDK 3 0.7 0.97542 -4.2208 0 0 0 0 0 0 0 8.94536 0 0 0 0 P20933 ASPG_HUMAN N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] AGA Homo sapiens (Human) protein deglycosylation [GO:0006517]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]; peptidase activity [GO:0008233] KSNLPVLLVPFLLCQALVR;NVIPDPSK 2 7.8 0.90867 -0.31316 0 0 0 5.35713 0 0 0 0 0 0 0 0 P20936 RASA1_HUMAN Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) RASA1 GAP RASA Homo sapiens (Human) blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102] EQIVEGYYLK;KEQIVEGYYLK;KGWYHGK 3 2.1 0.97605 -1.4528 0 0 0 0 0 0 9.76568 0 0 0 0 0 P20941 PHOS_HUMAN Phosducin (PHD) (33 kDa phototransducing protein) (Protein MEKA) PDC Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] phospholipase inhibitor activity [GO:0004859] EDENCLRKYR;GVINDWRKFK 2 8.1 0.88934 -0.18684 0 0 0 0 0 0 7.72799 0 0 0 0 0 P20962 PTMS_HUMAN Parathymosin PTMS Homo sapiens (Human) DNA replication [GO:0006260]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] histone binding [GO:0042393] AAEEEDEADPK;SVEAAAELSAK 2 21.6 0.058824 0.44189 0 0 12.3667 0 0 0 0 0 0 0 12.7185 0 P21127 CD11B_HUMAN Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) CDK11B CDC2L1 CDK11 PITSLREA PK58 Homo sapiens (Human) apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723] DSLEEGELR;EVSAHHRTMR;EYGSPLK;IWPGYSELPAVKKMTFSEHPYNNLR;YLPALQGCR 5 7.5 0.97414 -2.4595 9.83838 0 11.2685 0 0 0 8.97013 0 0 0 0 0 P21217 FUT3_HUMAN 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III) FUT3 FT3B LE Homo sapiens (Human) cell-cell recognition [GO:0009988]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; macromolecule glycosylation [GO:0043413]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of cell-cell adhesion [GO:0022409]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127] extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] SIAAWFT;WRETLRPR 2 4.2 0.98021 -1.6549 0 0 0 10.6456 0 0 0 0 0 8.67631 0 0 P21266 GSTM3_HUMAN Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3) GSTM3 GST5 Homo sapiens (Human) cellular detoxification of nitrogen compound [GO:0070458]; establishment of blood-nerve barrier [GO:0008065]; glutathione metabolic process [GO:0006749]; nitrobenzene metabolic process [GO:0018916]; response to estrogen [GO:0043627]; xenobiotic catabolic process [GO:0042178] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686] enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] ITQSNAILR;KHNMCGETEEEK;LDLDFPNLPYLLDGK 3 16 0.9478 -0.66328 13.8192 14.2972 0 10.2119 0 0 0 0 0 0 0 0 P21281 VATB2_HUMAN "V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)" ATP6V1B2 ATP6B2 VPP3 Homo sapiens (Human) ATP metabolic process [GO:0046034]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" EEVPGRR;EQALAVSR;LMKSAIGEGMTR;NYLSQPR;QIYPPINVLPSLSR;TPVSEDMLGR 6 11.4 0.88157 -0.16763 9.66295 12.0271 12.0523 0 10.1115 0 0 0 0 0 0 9.46565 P21283 VATC1_HUMAN V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) ATP6V1C1 ATP6C ATP6D VATC Homo sapiens (Human) proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401] "apical part of cell [GO:0045177]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DDFVLDSEYLVTLLVVVPKLNHNDWIK;SLAEIVK;TEFWLISAPGEK;TEFWLISAPGEKTCQQTWEK 4 14.1 0.95514 -0.81913 0 9.98527 0 0 0 0 0 0 0 0 0 11.9895 P21291 CSRP1_HUMAN Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141) CSRP1 CSRP CYRP Homo sapiens (Human) muscle tissue development [GO:0060537]; platelet aggregation [GO:0070527]; sarcomere organization [GO:0045214] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018] actinin binding [GO:0042805]; RNA binding [GO:0003723]; structural constituent of muscle [GO:0008307]; zinc ion binding [GO:0008270] CGVCQKTVYFAEEVQCEGNSFHK;GFGFGQGAGALVHSE 2 19.7 0 3.308 0 0 0 0 0 0 0 0 0 0 0 11.4976 P21333 FLNA_HUMAN Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood coagulation, intrinsic pathway [GO:0007597]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; establishment of Sertoli cell barrier [GO:0097368]; formation of radial glial scaffolds [GO:0021943]; heart morphogenesis [GO:0003007]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon regeneration [GO:0048680]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; synapse organization [GO:0050808]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; apical dendrite [GO:0097440]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; Myb complex [GO:0031523]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; Fc-gamma receptor I complex binding [GO:0034988]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; kinase binding [GO:0019900]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] AEAGVPAEFSIWTR;AEFTVETR;AFGPGLQGGSAGSPAR;AGGPGLER;AGVAPLQVK;ANLPQSFQVDTSK;AVGRGLQPKGVR;AWGPGLEGGVVGK;AYGPGIEPTGNMVK;EAGAGGLAIAVEGPSK;EATTEFSVDAR;FGGEHVPNSPFQVTALAGDQPSVQPPLR;FNEEHIPDSPFVVPVASPSGDAR;GAGTGGLGLAVEGPSEAK;GLVEPVDVVDNADGTQTVNYVPSR;GTVEPQLEAR;IQQNTFTR;IQQNTFTRWCNEHLK;LDVQFSGLTK;LLGWIQNK;LSPFMADIR;LTVSSLQESGLKVNQPASFAVSLNGAK;LVSIDSK;NDNDTFTVK;SPFEVYVDK;SPFSVAVSPSLDLSK;TGVAVNKPAEFTVDAK;TGVELGKPTHFTVNAK;VANPSGNLTETYVQDR;VGSAADIPINISETDLSLLTATVVPPSGR;VGTECGNQK;VKVEPSHDASK;VKVYGPGVAK;VLPTHDASK;VLPTHDASKVK;VNQPASFAVSLNGAK;VNVGAGSHPNK;VNVGAGSHPNKVK;VTANNDK;VTAQGPGLEPSGNIANK;YGGDEIPFSPYR;YGGQPVPNFPSK 42 19.8 0 65.924 13.4596 12.4966 13.5171 0 9.82874 10.2898 13.9815 13.1671 14.366 14.8307 15.089 14.5786 P21359 NF1_HUMAN Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] NF1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; collagen fibril organization [GO:0030199]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fibroblast proliferation [GO:0048144]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; liver development [GO:0001889]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; mast cell apoptotic process [GO:0033024]; mast cell proliferation [GO:0070662]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; myeloid leukocyte migration [GO:0097529]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; observational learning [GO:0098597]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mast cell apoptotic process [GO:0033027]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein import into nucleus [GO:0006606]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of gene expression [GO:0010468]; regulation of glial cell differentiation [GO:0045685]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; Schwann cell migration [GO:0036135]; Schwann cell proliferation [GO:0014010]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; visual learning [GO:0008542]; wound healing [GO:0042060]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] GTPase activator activity [GO:0005096]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429] ALESCLK;ARKSMSLDMGQPSQANTK;CLAGQPK;EILICRNKFLLK;FAFQYNPSLQPR;FAGPFSK;FINPAIVSPYEAGILDK;FLLKNKQADR;IQALLLTVLATLVK;LFLDSLR;LVSSKVIGR;TLKETQPWSSPK;VSHGQIKQIIRILSK;VTSLKFK 14 5.3 0.97816 -6.9109 4.11137 13.3154 8.27277 7.75328 10.0014 8.21043 7.904 0 11.6978 10.0449 0 11.4748 P21397 AOFA_HUMAN Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) MAOA Homo sapiens (Human) biogenic amine metabolic process [GO:0006576]; dopamine catabolic process [GO:0042420]; positive regulation of signal transduction [GO:0009967] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] aliphatic amine oxidase activity [GO:0052595]; flavin adenine dinucleotide binding [GO:0050660]; monoamine oxidase activity [GO:0097621]; primary methylamine oxidase activity [GO:0008131] DIWVQEPESK;ELGIETYKVNVSER;IHFRPELPAERNQLIQR;NEHVDYVDVGGAYVGPTQNR 4 11.6 0.9591 -1.0085 12.3283 0 0 0 0 0 0 0 10.6297 0 0 6.36578 P21399 ACOHC_HUMAN Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) ACO1 IREB1 Homo sapiens (Human) citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; post-embryonic development [GO:0009791]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] "3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA binding [GO:0003723]" AVLAESYER;IETVNESWNALATPSDK;YLQAVGMFR 3 3.9 0.91489 -0.33179 0 0 0 0 0 0 0 10.1485 7.1469 0 0 0 P21439 MDR3_HUMAN Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3) ABCB4 MDR3 PGY3 Homo sapiens (Human) bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid transporter activity [GO:0005548] AGEILTR;ELEAAGK;ILEEEMTR;SLDVETDGLEANVPPVSFLKVLKLNK;TVVSLTQER;VVSQDEIVSAAK 6 5.4 0.97703 -1.4916 13.4301 0 10.3889 7.92849 0 10.3956 0 0 0 0 0 10.7651 P21453 S1PR1_HUMAN Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) S1PR1 CHEDG1 EDG1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; brain development [GO:0007420]; cardiac muscle tissue growth involved in heart morphogenesis [GO:0003245]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chemotaxis [GO:0006935]; endothelial cell differentiation [GO:0045446]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula morphogenesis [GO:0061384]; lamellipodium assembly [GO:0030032]; leukocyte chemotaxis [GO:0030595]; negative regulation of stress fiber assembly [GO:0051497]; neuron differentiation [GO:0030182]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell migration [GO:0030335]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cell adhesion [GO:0030155]; regulation of metabolic process [GO:0019222]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell migration [GO:0072678]; transmission of nerve impulse [GO:0019226] cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793] G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; sphingolipid binding [GO:0046625]; sphingosine-1-phosphate receptor activity [GO:0038036] DEGDNPETIMSSGNVNSSS;LTFRKNISK 2 7.3 0.81544 -0.0031848 0 0 0 0 0 4.71039 0 0 2.04425 0 0 0 P21462 FPR1_HUMAN fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) FPR1 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; nitric oxide mediated signal transduction [GO:0007263]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal transduction [GO:0007165] azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; N-formyl peptide receptor activity [GO:0004982]; RAGE receptor binding [GO:0050786]; scavenger receptor binding [GO:0005124] KVIIGPWVMALLLTLPVIIR;QGLIKSSRPLR 2 8.9 0.97389 -1.4066 0 0 0 0 0 0 0 0 7.07585 9.43794 0 0 P21506 ZNF10_HUMAN Zinc finger protein 10 (Zinc finger protein KOX1) ZNF10 KOX1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CPDNDNSLTHGSSLGISK;DAKSLTAWSRTLVTFK;LLDTAQQIVYRNVMLENYK;SFSRSSHLIGHQK 4 11.5 0.96504 -1.1503 12.2363 0 0 0 9.22144 5.63378 4.88889 0 0 0 0 4.95555 P21549 AGT1_HUMAN Alanine--glyoxylate aminotransferase (AGT) (EC 2.6.1.44) (Serine--pyruvate aminotransferase) (SPT) (EC 2.6.1.51) AGXT AGT1 SPAT Homo sapiens (Human) "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; L-serine metabolic process [GO:0006563]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-serine-pyruvate transaminase activity [GO:0004760]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] EAAAYLHGR 1 2.3 0.92956 -0.47419 0 11.348 0 0 0 0 0 0 0 0 0 0 P21554 CNR1_HUMAN Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) CNR1 CNR Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; axonal fasciculation [GO:0007413]; cannabinoid signaling pathway [GO:0038171]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; negative regulation of action potential [GO:0045759]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of mast cell activation [GO:0033004]; negative regulation of serotonin secretion [GO:0014063]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood pressure [GO:0045777]; positive regulation of fever generation [GO:0031622]; positive regulation of neuron projection development [GO:0010976]; regulation of feeding behavior [GO:0060259]; regulation of insulin secretion [GO:0050796]; regulation of metabolic process [GO:0019222]; regulation of penile erection [GO:0060405]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]; spermatogenesis [GO:0007283]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802] STVKIAK;TITTDLLGSPFQEK 2 4.8 0.33672 0.24136 0 6.06555 12.205 0 0 0 0 0 0 0 0 0 P21579 SYT1_HUMAN Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) SYT1 SVP65 SYT Homo sapiens (Human) "calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; fast, calcium ion-dependent exocytosis of neurotransmitter [GO:0098746]; neurotransmitter secretion [GO:0007269]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of synaptic transmission [GO:0050806]; protein heterooligomerization [GO:0051291]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of exocytosis [GO:0017157]; regulation of regulated secretory pathway [GO:1903305]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]; synchronous neurotransmitter secretion [GO:0071911]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle organization [GO:0016050]; vesicle-mediated transport [GO:0016192]" axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasm [GO:0005737]; dense core granule [GO:0031045]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; low-density lipoprotein particle receptor binding [GO:0050750]; molecular condensate scaffold activity [GO:0140693]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]" LTVVILEAKNLKK;TLVMAVYDFDRFSK 2 6.4 0.90342 -0.2644 0 3.61129 0 7.72887 0 0 0 0 0 0 0 0 P21580 TNAP3_HUMAN Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] TNFAIP3 OTUD7C Homo sapiens (Human) "apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cytoskeleton organization [GO:0007010]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; negative regulation of B cell activation [GO:0050869]; negative regulation of bone resorption [GO:0045779]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of osteoclast proliferation [GO:0090291]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of defense response to virus by host [GO:0050691]; regulation of germinal center formation [GO:0002634]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; regulation of vascular wound healing [GO:0061043]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; tolerance induction to lipopolysaccharide [GO:0072573]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked deubiquitinase activity [GO:0061578]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; kinase binding [GO:0019900]; protease binding [GO:0002020]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AGCVYFGTPENK;MAEQVLPQALYLSNMR;MGPGAHRGEPAPEDPPK;TEEQLRSSQR;TPGDRTGTSK 5 8.2 0.97523 -3.3023 9.08422 0 0 4.81547 7.92683 0 0 9.98242 0 0 0 0 P21583 SCF_HUMAN Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] KITLG MGF SCF Homo sapiens (Human) cell adhesion [GO:0007155]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hematopoietic progenitor cell differentiation [GO:0002244]; male gonad development [GO:0008584]; mast cell apoptotic process [GO:0033024]; mast cell migration [GO:0097531]; mast cell proliferation [GO:0070662]; melanocyte migration [GO:0097324]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of mast cell apoptotic process [GO:0033026]; neural crest cell migration [GO:0001755]; ovarian follicle development [GO:0001541]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myeloid leukocyte differentiation [GO:0002763]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell proliferation [GO:0042102]; Ras protein signal transduction [GO:0007265]; response to organic cyclic compound [GO:0014070]; T cell proliferation [GO:0042098] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; stem cell factor receptor binding [GO:0005173] LVANLPKDYMITLK;TEGICRNR 2 8.1 0.97964 -1.9977 0 0 0 9.4544 0 0 0 0 0 12.8684 0 0 P21675 TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) TAF1 BA2R CCG1 CCGS TAF2A Homo sapiens (Human) cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin conjugating enzyme activity [GO:0061631] AFIAAMK;DFLQVFIYRLFWKSK;GTFGGNIIQHSIPAVELR;IDDEVRTAPWNTTR;KAFPSHSESSIR;QLIESADEVRR;QVTQMRQGR;VDFSSSSDSESEMGPQEATQAESEDGK;YSFGALSQPGPHSVQPLLK 9 7.1 0.97449 -3.6576 0 12.7825 0 9.11424 9.71608 0 0 6.24789 0 12.0161 7.64789 0 P21695 GPDA_HUMAN "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" GPD1 Homo sapiens (Human) cellular response to cAMP [GO:0071320]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerolipid metabolic process [GO:0046486]; glycerophosphate shuttle [GO:0006127]; NADH oxidation [GO:0006116]; positive regulation of glycolytic process [GO:0045821] cytosol [GO:0005829]; extracellular exosome [GO:0070062] glycerol-3-phosphate dehydrogenase (NAD+) activity [GO:0141152]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803] ELMQTPNFR;FPLFMAVYK;VAEAFAR;YLPGHKLPPNVFIGK 4 12.3 0.96643 -1.2854 0 0 0 0 0 9.81346 3.38101 0 0 9.15469 0 0 P21709 EPHA1_HUMAN Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of cell migration [GO:0030336]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; substrate adhesion-dependent cell spreading [GO:0034446] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; fibronectin binding [GO:0001968]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LWLKPYVDLQAYEDPAQGALDFTR;TIANFDPR;TVSEWLESIR;WPLGLGLVLLLCAPLPPGARAK 4 6.6 0.98033 -1.5956 0 0 0 0 0 0 0 0 0 8.7097 10.0467 0 P21709 EPHA1_HUMAN Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of cell migration [GO:0030336]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; substrate adhesion-dependent cell spreading [GO:0034446] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; fibronectin binding [GO:0001968]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GAGTGTWWRQK;WPLGLGLVLLLCAPLPPGARAK 2 7 0.88629 -0.18197 7.1151 0 0 0 0 0 0 0 0 0 0 0 P21730 C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) C5AR1 C5AR C5R1 Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; astrocyte activation [GO:0048143]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; cognition [GO:0050890]; complement component C5a signaling pathway [GO:0038178]; complement receptor mediated signaling pathway [GO:0002430]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; mRNA transcription by RNA polymerase II [GO:0042789]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynapse organization [GO:0099172]; response to peptidoglycan [GO:0032494]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930] AVAIVRLVLGFLWPLLTLTICYTFILLR;EEYFPPKVLCGVDYSHDK 2 13.1 0.84735 -0.0724 0 0 0 0 7.49961 5.40514 0 0 0 0 0 0 P21731 TA2R_HUMAN Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) TBXA2R Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; smooth muscle contraction [GO:0006939] acrosomal vesicle [GO:0001669]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961] LPGSSDSRASASR 1 3.2 0.97992 -1.5665 0 0 0 0 9.37038 9.26226 0 0 0 0 0 0 P21741 MK_HUMAN Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein) MDK MK1 NEGF2 Homo sapiens (Human) adrenal gland development [GO:0030325]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cerebellar granular layer development [GO:0021681]; cerebral cortex development [GO:0021987]; cytoskeleton organization [GO:0007010]; defecation [GO:0030421]; dentate gyrus development [GO:0021542]; estrous cycle [GO:0044849]; glial cell projection elongation [GO:0106091]; intracellular signal transduction [GO:0035556]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion [GO:0007162]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of regulatory T cell differentiation [GO:0045590]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of behavior [GO:0050795]; regulation of bone remodeling [GO:0046850]; regulation of chondrocyte differentiation [GO:0032330]; response to auditory stimulus [GO:0010996]; response to wounding [GO:0009611]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; T cell activation involved in immune response [GO:0002286]; tissue regeneration [GO:0042246] extracellular region [GO:0005576] chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201] GFLLLTLLALLALTSAVAKK;GFLLLTLLALLALTSAVAKKK;QHRGFLLLTLLALLALTSAVAK;VPCNWKK 4 21.7 0.89101 -0.21093 0 3.68661 7.51657 0 0 5.55262 11.8865 10.4335 9.6977 5.49483 0 0 P21757 MSRE_HUMAN Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) MSR1 SCARA1 Homo sapiens (Human) "amyloid-beta clearance [GO:0097242]; cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; negative regulation of gene expression [GO:0010629]; phagocytosis, engulfment [GO:0006911]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898]" collagen trimer [GO:0005581]; endocytic vesicle membrane [GO:0030666]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044] ESSIEECK;GFPGPIGPPGLKGDR;SFKAALIALYLLVFAVLIPLIGIVAAQLLK;VGQVVCR 4 13.3 0.96533 -1.1571 0 11.1586 0 0 4.48871 0 0 0 9.8738 0 0 0 P21781 FGF7_HUMAN Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor) FGF7 KGF Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; branching involved in salivary gland morphogenesis [GO:0060445]; endothelial cell proliferation [GO:0001935]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle morphogenesis [GO:0031069]; lung development [GO:0030324]; mesenchymal cell proliferation [GO:0010463]; myoblast proliferation [GO:0051450]; neurogenesis [GO:0022008]; positive chemotaxis [GO:0050918]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein localization to cell surface [GO:0034394]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell migration [GO:0030334]; regulation of synapse maturation [GO:0090128]; response to wounding [GO:0009611]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111] GKVKGTQEMK;GVESEFYLAMNK;LFCRTQWYLR 3 16.5 0.98004 -2.0103 0 0 0 0 7.61941 0 0 11.6331 0 0 10.916 0 P21796 VDAC1_HUMAN Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) VDAC1 VDAC Homo sapiens (Human) apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; calcium import into the mitochondrion [GO:0036444]; epithelial cell differentiation [GO:0030855]; learning [GO:0007612]; lipid transport [GO:0006869]; mitochondrial transmembrane transport [GO:1990542]; monoatomic anion transport [GO:0006820]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcium import into the mitochondrion [GO:0110099]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type 2 mitophagy [GO:1905091]; pyruvate metabolic process [GO:0006090]; regulation of autophagy of mitochondrion [GO:1903146] extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; synapse [GO:0045202] ATP binding [GO:0005524]; ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; oxysterol binding [GO:0008142]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic anion channel activity [GO:0008308]; voltage-gated monoatomic ion channel activity [GO:0005244] AVPPTYADLGK;LTFDSSFSPNTGK;LTFDSSFSPNTGKK;LTLSALLDGK;VNNSSLIGLGYTQTLKPGIK;VTQSNFAVGYK 6 23.3 0 9.7886 13.0797 12.9421 12.8471 10.2416 6.25646 8.93363 11.8538 11.5023 11.707 11.4866 11.0483 12.8689 P21802 FGFR2_HUMAN Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) FGFR2 BEK KGFR KSAM Homo sapiens (Human) angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; bone development [GO:0060348]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of a nerve [GO:0048755]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; digestive tract development [GO:0048565]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic organ development [GO:0048568]; embryonic organ morphogenesis [GO:0048562]; embryonic pattern specification [GO:0009880]; endochondral bone growth [GO:0003416]; epidermis morphogenesis [GO:0048730]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in hemopoiesis [GO:0035603]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell [GO:0035602]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [GO:0035604]; gland morphogenesis [GO:0022612]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lacrimal gland development [GO:0032808]; lateral sprouting from an epithelium [GO:0060601]; limb bud formation [GO:0060174]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; mammary gland bud formation [GO:0060615]; membranous septum morphogenesis [GO:0003149]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesodermal cell differentiation [GO:0048333]; midbrain development [GO:0030901]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; orbitofrontal cortex development [GO:0021769]; organ growth [GO:0035265]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; post-embryonic development [GO:0009791]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; prostate gland morphogenesis [GO:0060512]; protein autophosphorylation [GO:0046777]; pyramidal neuron development [GO:0021860]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoblast proliferation [GO:0033688]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of smoothened signaling pathway [GO:0008589]; reproductive structure development [GO:0048608]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; skeletal system morphogenesis [GO:0048705]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular zone neuroblast division [GO:0021847] cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] MLKDDATEK;TVLIGEYLQIK;VPEEQMTFK;VTKAAGVNTTDKEIEVLYIR 4 6 0.97508 -4.039 0 0 0 0 12.9218 9.71223 14.2355 0 0 9.96852 10.8855 0 P21810 PGS1_HUMAN Biglycan (Bone/cartilage proteoglycan I) (PG-S1) BGN SLRR1A Homo sapiens (Human) articular cartilage development [GO:0061975]; bone development [GO:0060348] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133] cytokine binding [GO:0019955]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539] IHDNRIRK;KDDFKGLQHLYALVLVNNK 2 7.3 0.95879 -1.0068 0 0 0 0 0 7.04439 0 0 0 0 0 0 P21815 SIAL_HUMAN Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) IBSP BNSP Homo sapiens (Human) bone mineralization [GO:0030282]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; extracellular matrix organization [GO:0030198]; osteoblast differentiation [GO:0001649]; positive regulation of cell adhesion [GO:0045785] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; vesicle [GO:0031982] integrin binding [GO:0005178]; small molecule binding [GO:0036094] IEDSEENGVFKYRPR 1 4.7 0.81281 -0.01152 0 0 0 0 0 0 0 0 0 0 10.2174 0 P21817 RYR1_HUMAN Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) RYR1 RYDR Homo sapiens (Human) calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; muscle contraction [GO:0006936]; ossification involved in bone maturation [GO:0043931]; outflow tract morphogenesis [GO:0003151]; protein homotetramerization [GO:0051289]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; skeletal muscle fiber development [GO:0048741]; skin development [GO:0043588]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; I band [GO:0031674]; junctional sarcoplasmic reticulum membrane [GO:0014701]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; ryanodine receptor complex [GO:1990425]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; terminal cisterna [GO:0014802]; Z disc [GO:0030018] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; intracellularly gated calcium channel activity [GO:0015278]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; voltage-gated calcium channel activity [GO:0005245] AFSMTAAETARR;AITLFPPGR;DFQKAMDSQK;DGGQHAR;DVIEEQGKRNFSK;GLSYRSLR;GRSLTKAQR;IERIYFEISETNRAQWEMPQVK;IRAILRSLVPLEDLVGIISLPLQIPTLGK;LEMQMLMPVSWSR;LLDEATK;NIMPLSAAMFQSERK;SLVPLEDLVGIISLPLQIPTLGK;VEGSPSLRWQMALYR 14 3.4 0.97798 -6.176 0 12.108 11.8212 0 10.5245 7.17343 5.11753 13.4261 9.98299 9.0177 0 0 P21854 CD72_HUMAN B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72) CD72 Homo sapiens (Human) cell adhesion [GO:0007155]; negative regulation of B cell receptor signaling pathway [GO:0050859] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] AEAITYADLR;LTDDTQRTRTYAQSSK;QQLRLKITQLGQSAEDLQGSR;VLEVTNSSLR 4 15.9 0.93663 -0.51823 8.82241 11.0869 11.0937 0 8.32269 0 0 0 0 0 0 8.26402 P21912 SDHB_HUMAN "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Malate dehydrogenase [quinone] iron-sulfur subunit) (EC 1.1.5.-)" SDHB SDH SDH1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273] "2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; succinate dehydrogenase (quinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]" QQYLQSIEEREK;SIEPYLKKK 2 7.5 0.97768 -1.5142 0 0 0 0 0 0 14.3373 0 0 6.47114 0 0 P21918 DRD5_HUMAN D(1B) dopamine receptor (D(5) dopamine receptor) (D1beta dopamine receptor) (Dopamine D5 receptor) DRD5 DRD1B DRD1L2 Homo sapiens (Human) "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; associative learning [GO:0008306]; cellular response to catecholamine stimulus [GO:0071870]; chemical synaptic transmission [GO:0007268]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; negative regulation of blood pressure [GO:0045776]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of MAPK cascade [GO:0043410]; reactive oxygen species metabolic process [GO:0072593]; regulation of female receptivity [GO:0045924]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; sensitization [GO:0046960]; synaptic transmission, dopaminergic [GO:0001963]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]" brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202] "dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]" YWAISRPFRYK 1 2.3 0.93296 -0.51284 0 0 0 0 0 0 0 0 0 0 10.3594 0 P21926 CD9_HUMAN CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9) CD9 MIC3 TSPAN29 GIG2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; platelet activation [GO:0030168]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991] integrin binding [GO:0005178] YLLFGFNFIFWLAGIAVLAIGLWLR 1 11 0.71211 0.15167 0 0 0 0 0 0 0 0 8.39776 0 0 0 P21941 MATN1_HUMAN Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein-containing complex assembly [GO:0065003]; regulation of bone mineralization [GO:0030500] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] ICVEEDPCACESLVK;TINQIGKK;VGMVNYASTVK 3 6.9 0.76966 0.055315 0 0 0 10.5288 11.0714 11.2069 13.1332 13.985 14.0229 7.99752 0 0 P21964 COMT_HUMAN Catechol O-methyltransferase (EC 2.1.1.6) COMT Homo sapiens (Human) "artery development [GO:0060840]; behavioral fear response [GO:0001662]; catecholamine catabolic process [GO:0042424]; cellular response to cocaine [GO:0071314]; cellular response to phosphate starvation [GO:0016036]; cerebellar cortex morphogenesis [GO:0021696]; cholesterol efflux [GO:0033344]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; dopamine secretion [GO:0014046]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; glomerulus development [GO:0032835]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; mastication [GO:0071626]; memory [GO:0007613]; methylation [GO:0032259]; multicellular organism growth [GO:0035264]; norepinephrine metabolic process [GO:0042415]; norepinephrine secretion [GO:0048243]; prostaglandin metabolic process [GO:0006693]; renal albumin absorption [GO:0097018]; renal filtration [GO:0097205]; renal sodium excretion [GO:0035812]; renin secretion into blood stream [GO:0002001]; response to amphetamine [GO:0001975]; response to angiotensin [GO:1990776]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to dopamine [GO:1903350]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to salt [GO:1902074]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; visual learning [GO:0008542]" axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] catechol O-methyltransferase activity [GO:0016206]; magnesium ion binding [GO:0000287]; methyltransferase activity [GO:0008168]; O-methyltransferase activity [GO:0008171] AIYKGPGSEAGP;EWAMNVGDK;GPGSEAGP;KYDVDTLDMVFLDHWK;LLSPGAR;MPEAPPLLLAAVLLGLVLLVVLLLLLR;YDVDTLDMVFLDHWK 7 26.2 0.97622 -2.2958 11.1627 10.9694 11.2301 8.04489 11.9861 6.04747 0 0 10.0602 0 10.8967 0 P21980 TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) TGM2 Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; bone development [GO:0060348]; branching involved in salivary gland morphogenesis [GO:0060445]; cellular response to cocaine [GO:0071314]; cellular response to dopamine [GO:1903351]; cellular response to serotonin [GO:1904015]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; peptide cross-linking [GO:0018149]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of neurogenesis [GO:0050769]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of sprouting angiogenesis [GO:1903672]; protein deamination [GO:0018277]; protein homooligomerization [GO:0051260]; proteolysis [GO:0006508]; regulation of apoptotic cell clearance [GO:2000425]; regulation of apoptotic process [GO:0042981]; salivary gland cavitation [GO:0060662] chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; histone dopaminyltransferase activity [GO:0120297]; histone serotonyltransferase activity [GO:0120295]; peptidase activity [GO:0008233]; peptide histaminyltransferase activity [GO:0120299]; peptide noradrenalinyltransferase activity [GO:0120298]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; protein-glutamine glutaminase activity [GO:0050568] ILGEPKQK 1 1.2 0.97799 -1.5051 0 0 0 0 0 0 0 0 12.2613 0 0 0 P22003 BMP5_HUMAN Bone morphogenetic protein 5 (BMP-5) BMP5 Homo sapiens (Human) allantois development [GO:1905069]; anterior head development [GO:0097065]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; chorio-allantoic fusion [GO:0060710]; ear development [GO:0043583]; endocardial cushion formation [GO:0003272]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; male genitalia development [GO:0030539]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of steroid biosynthetic process [GO:0010894]; neural fold elevation formation [GO:0021502]; ossification [GO:0001503]; pattern specification process [GO:0007389]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323] extracellular space [GO:0005615]; vesicle [GO:0031982] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083] DKDFSHQRR;GIVGFLWSCWVLVGYAK;QPFMVAFFKASEVLLRSVR;SVRAANK 4 10.8 0.039216 0.51089 0 0 0 7.80439 0 9.12606 0 0 0 0 11.0875 0 P22033 MUTA_HUMAN "Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)" MMUT MUT Homo sapiens (Human) "homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; propionate metabolic process, methylmalonyl pathway [GO:0019678]; succinyl-CoA biosynthetic process [GO:1901290]" cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803] EDAVEVLAIDNTSVR;EGRRPRLLVAK;EITSAIKRVHK;MVSGAYR;RLWAHLIEKMFQPK 5 7.7 0.97459 -3.4815 0 7.66881 0 8.41941 0 12.7618 0 0 0 0 4.46146 0 P22059 OSBP1_HUMAN Oxysterol-binding protein 1 OSBP OSBP1 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015] ELSKIPMPVNFNEPLSMLQR;IPYKPNYSLNLWSIMKNCIGK;LEETLEQLAK;RWFVLSNGLLSYYR;TELQNTLRTLSSKVEDLSTCNDLIAK 5 11.3 0.88122 -0.15065 0 0 10.1638 0 0 8.87735 11.1628 0 10.0697 0 0 0 P22079 PERL_HUMAN Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO) LPO SAPX Homo sapiens (Human) defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; thiocyanate peroxidase activity [GO:0036393] TITGDCNNRRKPALGAANR 1 2.7 0.84875 -0.076495 0 0 0 0 0 0 0 0 8.92914 0 0 0 P22083 FUT4_HUMAN "Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (ELAM-1 ligand fucosyltransferase) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)" FUT4 ELFT FCT3A Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; Lewis x epitope biosynthetic process [GO:0106402]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037] cell periphery [GO:0071944]; cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] AMGAPWGSPTAAAGGRRGWR;ANYERFVPR;LGPGRSGR;LLTDRASYGEAQAVLFHHRDLVK 4 11.3 0.97211 -2.6914 0 0 0 0 0 9.28637 10.0855 0 10.3314 8.14898 0 0 P22090 RS4Y1_HUMAN "Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4)" RPS4Y1 RPS4Y PRO2646 Homo sapiens (Human) translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] DANGNSFATR;LTVAEER;LVYDTKGR;VGVITNRER 4 12.9 0.97586 -2.2565 7.32832 0 0 0 0 0 0 0 0 0 0 0 P22102 PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART PGFT PRGS Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644] AAVAGLDK;AIAFLQQPR;NGSLTNHFSFEKKK;VINHKLYK;VKLAEHK 5 4.6 0.97408 -3.0094 12.5187 16.2509 13.3764 8.41473 8.53997 0 0 11.7064 0 8.32782 0 10.9572 P22105 TENX_HUMAN Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; fatty acid metabolic process [GO:0006631]; neuron projection development [GO:0031175]; positive regulation of cell fate determination [GO:1905935]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; triglyceride metabolic process [GO:0006641] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; tenascin complex [GO:0090733] collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; integrin binding [GO:0005178] AGPFSSR;AVAVSGLDPARKYK;CEDGECICDTGYSGDDCGVR;CEDGECICDTGYSGDDCGVRSCPGDCNQR;CENGVCVCNAGYSGEDCGVRSCPGDCRGR;CMCWPGYTGRDCGTR;CVCDPGYTGDDCGMR;DLQFSEIR;DRDGRPQVVR;DRDGRPR;FTLFGIANKKR;GECHDGSCVCK;GRCEDGRCVCWPGYTGTDCGSR;TQKLQGLIPGAR 14 4.9 0.97842 -7.5008 12.4518 7.49977 0 7.68923 5.96622 7.49681 7.10014 10.6733 0 5.90968 13.7645 10.6422 P22223 CADH3_HUMAN Cadherin-3 (Placental cadherin) (P-cadherin) CDH3 CDHP Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; hair cycle process [GO:0022405]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinization [GO:0031424]; negative regulation of timing of catagen [GO:0051796]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanosome transport [GO:1902910]; positive regulation of tyrosinase activity [GO:0032773]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; visual perception [GO:0007601] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EDEQFVR;GGFILPVLGAVLALLFLLLVLLLLVRKK;QITICNQSPVR 3 5.5 0.74543 0.090902 13.2377 0 9.23007 0 4.35219 10.16 0 12.0177 11.7719 12.5019 0 11.4462 P22234 PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] PAICS ADE2 AIRC PAIS Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639] ASILNTWISLK;ATAEVLNIGK;ATAEVLNIGKK;DQITAGNAAR;EVYELLDSPGK;NPGVKEGYK;VLLQSKDQITAGNAAR 7 13.6 0 21.961 10.2155 12.3865 11.8204 11.4999 10.2212 10.6928 11.9209 11.837 11.9682 11.4221 9.43781 0 P22303 ACES_HUMAN Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Homo sapiens (Human) "acetylcholine catabolic process [GO:0006581]; acetylcholine catabolic process in synaptic cleft [GO:0001507]; acetylcholine receptor signaling pathway [GO:0095500]; amyloid precursor protein metabolic process [GO:0042982]; cell adhesion [GO:0007155]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; nervous system development [GO:0007399]; osteoblast development [GO:0002076]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]" basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; synaptic cleft [GO:0043083] acetylcholine binding [GO:0042166]; acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; cholinesterase activity [GO:0004104]; collagen binding [GO:0005518]; hydrolase activity [GO:0016787]; laminin binding [GO:0043236]; protein homodimerization activity [GO:0042803]; serine hydrolase activity [GO:0017171] LLSATDTLDEAER;TVLVSMNYR 2 3.6 0.93051 -0.47772 0 0 0 12.9853 0 4.0464 11.42 0 0 0 0 0 P22304 IDS_HUMAN Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] IDS SIDS Homo sapiens (Human) dermatan sulfate catabolic process [GO:0030209]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200] cytoplasm [GO:0005737]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] calcium ion binding [GO:0005509]; iduronate-2-sulfatase activity [GO:0004423] DIKIMGYSIRTIDYR;EGKNLLK 2 4 0.95479 -0.95063 0 0 0 0 0 0 4.50093 0 0 0 0 8.63267 P22307 SCP2_HUMAN Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X) SCP2 Homo sapiens (Human) alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular cholesterol transport [GO:0032367]; lipid hydroperoxide transport [GO:1901373]; phospholipid transport [GO:0015914]; positive regulation of intracellular cholesterol transport [GO:0032385]; positive regulation of steroid metabolic process [GO:0045940]; progesterone biosynthetic process [GO:0006701]; protein localization to plasma membrane [GO:0072659]; regulation of phospholipid biosynthetic process [GO:0071071]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; oleic acid binding [GO:0070538]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol transfer activity [GO:0008526]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]; signaling receptor binding [GO:0005102] GEAGKRQVPGAK;ITGNMGLAMK;RQVPGAK 3 4 0.97644 -1.4785 0 0 0 0 0 7.55635 0 0 0 0 9.71913 0 P22314 UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) UBA1 A1S9T UBE1 Homo sapiens (Human) DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin activating enzyme activity [GO:0004839] AAVATFLQSVQVPEFTPK;AENYDIPSADR;ALPAVQQNNLDEDLIR;ALPAVQQNNLDEDLIRK;ATLPSPDKLPGFK;CVYYRKPLLESGTLGTK;DNPGVVTCLDEAR;GGIVSQVK;GLGVEIAK;GNVQVVIPFLTESYSSSQDPPEK;KPLLESGTLGTK;LAGTQPLEVLEAVQR;LDQPMTEIVSR;LKSDTAAAAVR;LQTSSVLVSGLR;LVVADTR;NEEDAAELVALAQAVNAR;NGSEADIDEGLYSR;NIILGGVK;SDTAAAAVR;SLVASLAEPDFVVTDFAK;VGEFCHNRGIKLVVADTR;VGPDTER;VTSHQNR;YDGQVAVFGSDLQEK 25 26.7 0 152.37 10.663 12.7808 10.7525 8.73054 8.25186 0 14.7715 15.3132 15.5265 14.3558 14.0493 0 P22392 NDKB_HUMAN Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) NME2 NM23B Homo sapiens (Human) cell adhesion [GO:0007155]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of epidermis development [GO:0045682]; UTP biosynthetic process [GO:0006228] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; DNA binding [GO:0003677]; G-quadruplex DNA binding [GO:0051880]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; phosphorelay sensor kinase activity [GO:0000155]; transcription coactivator activity [GO:0003713] FMQASEDLLK;GLVGEIIK;NIIHGSDSVK;TFIAIKPDGVQR;VMLGETNPADSKPGTIR 5 35.2 0 8.9567 14.5416 14.0993 14.0371 11.2738 10.1803 10.4139 13.5255 13.8496 13.5468 10.1695 12.064 12.8517 P22413 ENPP1_HUMAN "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]" ENPP1 M6S1 NPPS PC1 PDNP1 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; ATP metabolic process [GO:0046034]; bone mineralization [GO:0030282]; cellular response to insulin stimulus [GO:0032869]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; immune response [GO:0006955]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; melanocyte differentiation [GO:0030318]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell growth [GO:0030308]; negative regulation of D-glucose import [GO:0046325]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of hh target transcription factor activity [GO:1990787]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein autophosphorylation [GO:0031953]; nucleic acid metabolic process [GO:0090304]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; regulation of bone mineralization [GO:0030500]; response to ATP [GO:0033198]; sequestering of triglyceride [GO:0030730] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; 8-oxo-(d)RTP hydrolase activity [GO:0106379]; ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; calcium ion binding [GO:0005509]; cyclic-GMP-AMP hydrolase activity [GO:0106177]; dinucleotide phosphatase activity [GO:0004551]; exonuclease activity [GO:0004527]; GTP diphosphatase activity [GO:0036219]; insulin receptor binding [GO:0005158]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphatase activity [GO:0016791]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; protein homodimerization activity [GO:0042803]; scavenger receptor activity [GO:0005044]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270]" ERDGCAGGGSRGGEGGR;TDNSESCVHGK 2 3 0.84346 -0.052999 0 0 0 0 5.25096 5.19421 7.36054 0 0 0 0 0 P22415 USF1_HUMAN Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) USF1 BHLHB11 USF Homo sapiens (Human) carbon catabolite regulation of transcription [GO:0045990]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]; response to hypoxia [GO:0001666]; response to UV [GO:0009411] chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" NLLLRAQLR;SIAPRTHPYSPK 2 6.8 0.9094 -0.27847 0 0 0 9.29485 6.85885 0 0 0 0 0 0 0 P22455 FGFR4_HUMAN Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) FGFR4 JTK2 TKF Homo sapiens (Human) cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cholesterol homeostasis [GO:0042632]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glucose homeostasis [GO:0042593]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphate ion homeostasis [GO:0055062]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of proteolysis [GO:0045862]; protein autophosphorylation [GO:0046777]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of lipid metabolic process [GO:0019216] endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] IGGIRLR 1 0.9 0.68125 0.16447 0 0 0 0 0 0 0 0 0 8.41418 0 0 P22459 KCNA4_HUMAN Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4) KCNA4 KCNA4L Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] axon [GO:0030424]; axon initial segment [GO:0043194]; dendritic spine [GO:0043197]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; potassium ion binding [GO:0030955]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] ELSEEEEDEEEEEEEEEEGR;FETQMKTLAQFPETLLGDPEK;HSKGLQILGHTLRASMR;RTQYFDPLRNEYFFDR;YSDCCER 5 12.4 0.91456 -0.33516 6.58892 0 0 6.74645 0 4.82395 0 0 0 8.67811 0 0 P22557 HEM0_HUMAN "5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)" ALAS2 ALASE ASB Homo sapiens (Human) erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to hypoxia [GO:0001666] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170] FVFRHNDPDHLKK;MVTAAMLLQCCPVLARGPTSLLGKVVK 2 6.8 0.69386 0.16215 0 0 0 0 0 0 11.0259 0 0 0 0 0 P22557 HEM0_HUMAN "5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)" ALAS2 ALASE ASB Homo sapiens (Human) erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to hypoxia [GO:0001666] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170] FVFRHNDPDHLKK;SYDQFFRDKIMEK 2 5.8 0.74881 0.085032 0 0 0 0 0 0 0 9.25127 0 0 0 7.39008 P22607 FGFR3_HUMAN Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) FGFR3 JTK4 Homo sapiens (Human) bone maturation [GO:0070977]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; negative regulation of developmental growth [GO:0048640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; skeletal system development [GO:0001501] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DLVSCAYQVAR;GEHRIGGIKLR;GLGSPTVHKISRFPLK;LANVSER;VLCHFSVR 5 6.6 0.97318 -2.5904 0 10.0208 0 0 0 0 0 0 0 0 0 0 P22612 KAPCG_HUMAN cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) PRKACG Homo sapiens (Human) high-density lipoprotein particle assembly [GO:0034380]; male gonad development [GO:0008584]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ISINEKCAK;ISINEKCAKEFSEF;LRTLGMGSFGR;VEAPFIPK 4 9.4 0.97318 -2.9425 0 0 12.835 0 0 0 0 0 0 9.52456 11.3856 7.73464 P22626 ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Homo sapiens (Human) "G-quadruplex DNA unwinding [GO:0044806]; miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; primary miRNA processing [GO:0031053]; RNA transport [GO:0050658]" "Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]" G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047] EESGKPGAHVTVK;GGGGNFGPGPGSNFR;GGNFGFGDSR;IDTIEIITDR;NMGGPYGGGNYGPGGSGGSGGYGGR;NYYEQWGK;QEMQEVQSSR;TLETVPLER 8 28.3 0 80.09 14.7985 14.6749 14.7236 11.3449 11.2289 10.9482 8.00039 12.4552 12.2575 14.3086 14.0756 11.5286 P22670 RFX1_HUMAN MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) RFX1 Homo sapiens (Human) immune response [GO:0006955]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LPKAILVLLSK;RLPKAILVLLSK 2 1.2 0.22739 0.30197 0 0 3.74222 0 0 0 0 9.84955 0 6.14443 0 3.36149 P22676 CALB2_HUMAN Calretinin (CR) (29 kDa calbindin) CALB2 CAB29 Homo sapiens (Human) regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509] cytosol [GO:0005829]; dendrite [GO:0030425]; gap junction [GO:0005921]; nucleus [GO:0005634]; parallel fiber to Purkinje cell synapse [GO:0098688]; synapse [GO:0045202]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534] GSGMMSK;KANRPYDEPK 2 6.3 0.22884 0.29783 0 11.1349 0 8.29278 0 0 0 0 0 0 0 0 P22681 CBL_HUMAN E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) CBL CBL2 RNF55 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response [GO:0006974]; male gonad development [GO:0008584]; mast cell degranulation [GO:0043303]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of Rap protein signal transduction [GO:0032487]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; ubiquitin-dependent endocytosis [GO:0070086]; ubiquitin-dependent protein catabolic process [GO:0006511] cilium [GO:0005929]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; ephrin receptor binding [GO:0046875]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ALVIAQNNIEMAKNILR 1 1.9 0.92174 -0.43918 0 0 9.89772 0 0 0 0 0 0 0 0 0 P22692 IBP4_HUMAN Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4) IGFBP4 IBP4 Homo sapiens (Human) MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102] NGNFHPK;TGVKLPGGLEPK 2 7.4 0.9338 -0.51089 0 0 0 0 0 7.4614 10.5961 7.07017 0 0 0 0 P22694 KAPCB_HUMAN cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) PRKACB Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; high-density lipoprotein particle assembly [GO:0034380]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; protein phosphorylation [GO:0006468]; regulation of protein processing [GO:0070613]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165] cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625] GTAHDQK;VEAPFIPK 2 3.8 0.64929 0.17061 0 0 0 0 0 0 0 0 0 9.87964 0 0 P22695 QCR2_HUMAN "Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)" UQCRC2 Homo sapiens (Human) "aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; proteolysis [GO:0006508]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] LSVTATR;LTSSLTTK;QVAEQFLNMR;WEVADLQPQLK 4 7.9 0.97949 -1.9941 0 0 0 0 0 0 12.5681 0 0 0 8.54148 0 P22732 GTR5_HUMAN "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 GLUT5 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cellular response to fructose stimulus [GO:0071332]; D-glucose transmembrane transport [GO:1904659]; fructose import across plasma membrane [GO:1990539]; fructose transmembrane transport [GO:0015755]; intestinal hexose absorption [GO:0106001]; regulation of systemic arterial blood pressure mediated by a chemical signal [GO:0003044]; response to fructose [GO:0009750] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; specific granule membrane [GO:0035579] D-glucose transmembrane transporter activity [GO:0055056]; fructose binding [GO:0070061]; fructose transmembrane transporter activity [GO:0005353] AAGFISVLKLFRMR;EELKELPPVTSEQ 2 5.4 0.9458 -0.65461 0 0 0 0 0 0 0 0 0 8.39322 10.284 0 P22735 TGM1_HUMAN Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 KTG Homo sapiens (Human) cell envelope organization [GO:0043163]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein modification process [GO:0036211] cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] GMPYGGRGDPVNVSR;SFWARCCGCCSCR;SFWARCCGCCSCRNAADDDWGPEPSDSR 3 5.3 0.97618 -2.2531 0 10.5875 0 0 0 0 0 0 0 4.08958 0 0 P22760 AAAD_HUMAN Arylacetamide deacetylase (EC 3.1.1.3) AADAC DAC Homo sapiens (Human) lipid metabolic process [GO:0006629]; positive regulation of triglyceride catabolic process [GO:0010898]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] catalytic activity [GO:0003824]; deacetylase activity [GO:0019213]; lipase activity [GO:0016298]; serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806] KSLYLLIVGILIAYYIYTPLPDNVEEPWR 1 7.3 0.38525 0.21542 0 0 0 0 0 0 0 0 0 5.50653 0 0 P22830 HEMH_HUMAN "Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)" FECH Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; cholesterol metabolic process [GO:0008203]; detection of UV [GO:0009589]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; multicellular organismal-level iron ion homeostasis [GO:0060586]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of hemoglobin biosynthetic process [GO:0046984]; response to arsenic-containing substance [GO:0046685]; response to ethanol [GO:0045471]; response to insecticide [GO:0017085]; response to lead ion [GO:0010288]; response to light stimulus [GO:0009416]; response to methylmercury [GO:0051597]; response to platinum ion [GO:0070541]; response to xenobiotic stimulus [GO:0009410]; very-low-density lipoprotein particle assembly [GO:0034379] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; ferrochelatase activity [GO:0004325]; ferrous iron binding [GO:0008198]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron-responsive element binding [GO:0030350]; protein homodimerization activity [GO:0042803]" VCQPWRWK 1 1.9 0.98199 -1.587 0 0 0 9.33244 0 0 0 0 0 0 0 0 P22888 LSHR_HUMAN Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R) LHCGR LCGR LGR2 LHRHR Homo sapiens (Human) "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; arachidonate secretion [GO:0050482]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to luteinizing hormone stimulus [GO:0071373]; cognition [GO:0050890]; development of secondary male sexual characteristics [GO:0046544]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone signaling pathway [GO:0042700]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; ovarian follicle development [GO:0001541]; ovulation cycle process [GO:0022602]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting to lysosome [GO:0006622]; regulation of steroid hormone biosynthetic process [GO:0090030]; response to xenobiotic stimulus [GO:0009410]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]" centriolar satellite [GO:0034451]; endosome [GO:0005768]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATPase binding [GO:0051117]; choriogonadotropin hormone binding [GO:0038106]; choriogonadotropin hormone receptor activity [GO:0035472]; G protein-coupled peptide receptor activity [GO:0008528]; identical protein binding [GO:0042802]; luteinizing hormone receptor activity [GO:0004964]; peptide hormone binding [GO:0017046] FSALQLLKLLLLLQPPLPR;FSALQLLKLLLLLQPPLPRALR;QRFSALQLLKLLLLLQPPLPR;YIEPGAFINLPRLK 4 5.4 0.86976 -0.096131 10.4746 0 6.76911 7.95884 7.57781 7.8116 8.90686 9.00921 9.91921 6.10251 6.23733 0 P22891 PROZ_HUMAN Vitamin K-dependent protein Z PROZ Homo sapiens (Human) blood coagulation [GO:0007596]; proteolysis [GO:0006508] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] NECHPER;VEPSVFLPASKANDVLVRWK;VSRYSLWFK 3 9 0.95466 -0.93853 0 0 0 8.94439 0 0 0 11.7328 7.58271 0 0 0 P22894 MMP8_HUMAN Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) MMP8 CLG1 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor binding [GO:0043120]; zinc ion binding [GO:0008270] FSLKTLPFLLLLHVQISK;NTKTVQDYLEK;TLPFLLLLHVQISK;VARGNKWLNCR 4 8.6 0.97332 -2.9066 0 0 0 0 0 0 0 15.0376 9.40216 0 0 0 P22897 MRC1_HUMAN Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; D-mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] EGWNFYSNK;FRWVSESQIMSVAFK;SSYSLMR;VRYTNWAADEPK;YTNWAADEPKLK 5 3.1 0.97601 -4.3141 0 0 0 7.67087 7.65835 7.82305 0 12.446 9.44052 0 8.451 0 P22914 CRYGS_HUMAN Gamma-crystallin S (Beta-crystallin S) (Gamma-S-crystallin) CRYGS CRYG8 Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] RYDCDCDCADFHTYLSRCNSIK;YDCDCDCADFHTYLSR 2 12.4 0.40265 0.20805 0 0 0 0 0 0 0 6.33955 6.14301 0 0 0 P23109 AMPD1_HUMAN AMP deaminase 1 (EC 3.5.4.6) (AMP deaminase isoform M) (Myoadenylate deaminase) AMPD1 Homo sapiens (Human) AMP metabolic process [GO:0046033]; GMP salvage [GO:0032263]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264] cytosol [GO:0005829] AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ALCIREKYMQK;GLYRALCIR;QTFQRFDK;SFQRFPK;SPKPQEWTLEK;VQITGDYASGVTVEDFEIVCKGLYR 6 8.3 0.97488 -3.189 0 10.3067 0 0 10.114 0 0 0 0 9.59462 8.35913 0 P23141 EST1_HUMAN Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH) CES1 CES2 SES1 Homo sapiens (Human) cellular response to cholesterol [GO:0071397]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol ester hydrolysis involved in cholesterol transport [GO:0090122]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to toxic substance [GO:0009636]; reverse cholesterol transport [GO:0043691] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811] carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; sterol ester esterase activity [GO:0004771] ELIPEATEK;EVAFWTNLFAKKAVEKPPQTEHIEL 2 6 0.90965 -0.28278 0 0 9.26475 0 0 0 0 0 0 0 0 0 P23142 FBLN1_HUMAN Fibulin-1 (FIBL-1) FBLN1 PP213 Homo sapiens (Human) "blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]" basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protein-containing complex binding [GO:0044877] GGGPCKQQCR;KVSPHSGVVALTKPVPEPR;NVPNCGR;YPGRLCGHK 4 6.6 0.9776 -1.5138 0 8.96535 12.066 8.35434 0 0 0 0 0 3.92467 0 0 P23193 TCEA1_HUMAN Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) TCEA1 GTF2S TFIIS Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] APSTSDSVR;DTYVSSFPR;FAKKMDK;LLDGPSTEK;MDKMVQKK 5 13 0.97445 -3.78 6.90099 0 0 0 8.92086 0 11.1342 0 0 12.7662 10.1081 6.73363 P23219 PGH1_HUMAN Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 Homo sapiens (Human) cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; photoreceptor outer segment [GO:0001750] "heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]" LVCLNTK;MLMRLVLTVR 2 3.5 0.98119 -1.5903 0 11.7759 0 0 0 0 0 0 0 0 0 0 P23229 ITA6_HUMAN Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] ITGA6 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to organic cyclic compound [GO:0071407]; ectodermal cell differentiation [GO:0010668]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; nail development [GO:0035878]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skin morphogenesis [GO:0043589] adherens junction [GO:0005912]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; integrin alpha6-beta1 complex [GO:0034675]; integrin alpha6-beta4 complex [GO:0034676]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; insulin-like growth factor I binding [GO:0031994]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; neuregulin binding [GO:0038132] IEDDMDGGDWSFCDGR;LEYKFCTREGNQDK;SRPVINIQKTITVTPNRIDLR;TITVTPNR;TITVTPNRIDLR;VQFRNQGSEPK;YDDSVPR 7 6.1 0.97776 -2.166 0 7.10685 8.7497 9.56944 0 0 4.21638 6.13145 0 0 0 0 P23246 SFPQ_HUMAN "Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" SFPQ PSF Homo sapiens (Human) "activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]" chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976] AVVIVDDR;FGQGGAGPVGGQGPR;MGYMDPR;NPMYQKER;NPMYQKERETPPR;QGPGPGGPK;QREMEEQMRR;RGGGGGR;SPPPGMGLNQNR;YGEPGEVFINK 10 13 0 26.612 14.157 12.2316 13.7592 9.45022 8.45035 11.0179 12.4379 12.4367 12.5686 12.5252 15.0758 0 P23276 KELL_HUMAN Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238) KEL Homo sapiens (Human) establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; negative regulation of potassium ion transmembrane transport [GO:1901380]; potassium ion transmembrane transport [GO:0071805]; protein processing [GO:0016485]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]; vasoconstriction [GO:0042310] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EGGDQSEEEPRER;IVQSFLQPHPQHRWK 2 3.8 0.94577 -0.65254 0 0 0 0 0 0 0 5.04085 0 0 11.739 0 P23284 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB Homo sapiens (Human) bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; neutrophil chemotaxis [GO:0030593]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral process [GO:0044794]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; unfolded protein binding [GO:0051082] DTNGSQFFITTVK;DVIIADCGKIEVEKPFAIAKE;IGDEDVGR;LSERNMK;TVDNFVALATGEK;TVDNFVALATGEKGFGYK;VIKDFMIQGGDFTR;VLEGMEVVR 8 41.7 0 67.44 13.6024 13.0819 12.9408 10.3326 11.4599 0 14.1862 14.374 14.009 12.633 13.372 12.5857 P23297 S10A1_HUMAN Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1) S100A1 S100A Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of heart contraction [GO:0008016]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum [GO:0016529] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548] DVDAVDKVMK 1 10.6 0.88853 -0.18813 0 0 0 8.31456 0 0 0 0 0 0 0 0 P23327 SRCH_HUMAN Sarcoplasmic reticulum histidine-rich calcium-binding protein HRC HCP Homo sapiens (Human) muscle contraction [GO:0006936]; positive regulation of heart contraction [GO:0045823]; positive regulation of heart rate [GO:0010460]; positive regulation of relaxation of cardiac muscle [GO:1901899]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314] endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325] EEEEEEEDEER;EEEEEEEDEERR;SDEEDFQDEYK;SHLRKDDSEEEK 4 5 0.74524 0.087716 0 0 0 0 6.69738 0 2.93472 10.8982 0 2.79973 0 5.9653 P23352 KALM_HUMAN Anosmin-1 (Adhesion molecule-like X-linked) (Kallmann syndrome protein) ANOS1 ADMLX KAL KAL1 KALIG1 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; neuron differentiation [GO:0030182] cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] CCSNGCGHTCQVPK;LDESLSAGSVQR;WSSKFNISIEPVIYVVQR 3 6.5 0.77067 0.052896 5.92203 0 0 0 9.67311 9.12807 0 10.317 0 0 0 0 P23368 MAOM_HUMAN "NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)" ME2 Homo sapiens (Human) malate metabolic process [GO:0006108]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948] TNKGMAFTLQER;YIYIMGIQERNEK 2 4.3 0.9589 -1.0399 0 0 0 0 0 0 0 0 10.6678 0 10.9336 0 P23378 GCSP_HUMAN "Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))" GLDC GCSP Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255] glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] electron transfer activity [GO:0009055]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]; pyridoxal phosphate binding [GO:0030170] GVGGGRR;TVPANIRLKRPLK 2 2 0.75096 0.079916 0 0 0 0 0 2.26822 0 0 0 0 9.9552 10.4545 P23381 SYWC_HUMAN "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS1 IFI53 WARS WRS Homo sapiens (Human) angiogenesis [GO:0001525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tryptophanyl-tRNA aminoacylation [GO:0006436] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; kinase inhibitor activity [GO:0019210]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; tryptophan-tRNA ligase activity [GO:0004830] DIIACGFDINK;IDKELINRIER;MSASDPNSSIFLTDTAK;TKVNKHAFSGGR 4 10.8 0.91556 -0.34783 0 10.2586 6.84273 0 9.11723 0 0 0 0 8.4744 0 0 P23396 RS3_HUMAN Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) RPS3 OK/SW-cl.26 Homo sapiens (Human) apoptotic process [GO:0006915]; base-excision repair [GO:0006284]; cell division [GO:0051301]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; chromosome segregation [GO:0007059]; cytoplasmic translation [GO:0002181]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of DNA repair [GO:0045738]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of translation [GO:0017148]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of base-excision repair [GO:1905053]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA repair [GO:0045739]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of apoptotic process [GO:0042981]; response to TNF agonist [GO:0061481]; spindle assembly [GO:0051225]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitotic spindle [GO:0072686]; NF-kappaB complex [GO:0071159]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; ruffle membrane [GO:0032587] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron-sulfur cluster binding [GO:0051536]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; mRNA binding [GO:0003729]; oxidized purine DNA binding [GO:0032357]; oxidized pyrimidine DNA binding [GO:0032358]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; supercoiled DNA binding [GO:0097100]; tubulin binding [GO:0015631]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] AELNEFLTR;DEILPTTPISEQK;ELAEDGYSGVEVR;FIMESGAK;GCEVVVSGKLRGQR;GGKPEPPAMPQPVPTA;IMLPWDPTGK;QGVLGIK;TQNVLGEK 9 40.3 0 23.762 12.8701 11.3597 12.5123 9.92801 10.1397 8.93761 11.5819 10.4606 12.5462 13.1068 13.0627 10.3646 P23416 GLRA2_HUMAN Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218] chloride channel complex [GO:0034707]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DGTAVKATPANPLPQPPK;KFVDRAK;VNIFLRQQWNDSR 3 8.4 0.97497 -2.3759 0 0 0 0 0 0 10.4706 0 0 0 8.35019 0 P23434 GCSH_HUMAN "Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)" GCSH Homo sapiens (Human) glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; protein lipoylation [GO:0009249] glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aminomethyltransferase activity [GO:0004047] SVRALLCTLR 1 5.8 0.8883 -0.18435 0 9.90456 0 0 0 0 0 0 0 0 10.482 0 P23435 CBLN1_HUMAN Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin] CBLN1 Homo sapiens (Human) "cerebellar granule cell differentiation [GO:0021707]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; nervous system development [GO:0007399]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083] identical protein binding [GO:0042802] KGIYSFNFHVVKVYNR 1 8.3 0.85044 -0.078994 0 0 0 0 8.23611 0 0 5.06242 0 0 0 0 P23443 KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) RPS6KB1 STK14A Homo sapiens (Human) apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; cell migration [GO:0016477]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to nutrient [GO:0031670]; cellular response to type II interferon [GO:0071346]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell development [GO:0007281]; long-chain fatty acid import into cell [GO:0044539]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TORC2 signaling [GO:1903940]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of D-glucose import [GO:0046324]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to L-leucine [GO:0043201]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; response to toxic substance [GO:0009636]; response to tumor necrosis factor [GO:0034612]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle contraction [GO:0003009]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GPEKIRPECFELLRVLGK;LTDFGLCK;QAFPMISK;QAFPMISKRPEHLR;QPNSGPYKK;VTGANTGK 6 10.9 0.97614 -2.2601 0 0 0 0 9.44597 0 9.75812 0 8.35147 0 0 10.421 P23458 JAK1_HUMAN Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) JAK1 JAK1A JAK1B Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; response to antibiotic [GO:0046677]; T-helper 17 cell lineage commitment [GO:0072540]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; CCR5 chemokine receptor binding [GO:0031730]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625] FYFTNWHGTNDNEQSVWR 1 1.6 0.68132 0.1649 8.0648 0 0 0 6.59695 0 8.73464 6.96659 7.44394 0 6.82477 0 P23467 PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB Homo sapiens (Human) angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470] plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DLLLIHK;LVRTAPMEVSNLK;TFPLAVLQLRVK;TVRDYINR 4 2.1 0.88798 -0.19018 0 0 0 0 0 0 6.04913 0 0 0 0 0 P23467 PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB Homo sapiens (Human) angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470] plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DLLLIHK;IDVNKEGKLVNESLCLQK;LVRTAPMEVSNLK;TIQNQQWMWTEDEKLLHVK;TVRDYINR 5 2.9 0.975 -3.6165 0 7.22207 10.7986 3.4194 3.84157 0 10.9455 0 0 10.8169 0 0 P23468 PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; cellular response to hypoxia [GO:0071456]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of synapse assembly [GO:0051965]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; regulation of immune response [GO:0050776]; regulation of postsynaptic density assembly [GO:0099151]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] "cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" GASYVFRLSARNK;LLLLLLTFFLR;MENGEPK;VHVARLLLLLLTFFLR;VTDARDGQSRTVR;YLLEQLEK 6 3 0.9759 -2.327 9.11814 8.93319 9.18393 0 0 0 0 0 11.7259 0 8.68022 0 P23469 PTPRE_HUMAN Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IMKENMR;KYFPIPVEHLEEEIR 2 3.1 0.96579 -1.1308 0 0 0 0 0 0 0 0 0 0 8.7253 10.0315 P23470 PTPRG_HUMAN Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" HKNRYINILAYDHSR;IHACYTVR;LVTQCNAK 3 2.1 0.95437 -0.93105 0 0 0 5.7699 0 0 0 0 0 0 0 0 P23471 PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; neuron projection development [GO:0031175]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein dephosphorylation [GO:0006470]; regulation of myelination [GO:0031641]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; signal transduction [GO:0007165] extracellular region [GO:0005576]; perineuronal net [GO:0072534]; plasma membrane [GO:0005886]; synapse [GO:0045202] "histone H2AXY142 phosphatase activity [GO:0140793]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" ITFHWGK;KLVEEIGWSYTGALNQK;YINIVAYDHSRVKLAQLAEK 3 1.9 0.88147 -0.15941 0 5.65978 0 0 0 0 9.01237 9.15277 0 0 0 0 P23497 SP100_HUMAN Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) SP100 Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator [GO:0030330]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" "chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" ADKAHYER;GKPNSAK;KEEEEDEEDEQEEENEEDDDK;LSIRCGGYTLK 4 5.3 0.96353 -1.0949 8.47942 0 0 0 0 0 7.20046 11.5715 11.3342 0 0 0 P23497 SP100_HUMAN Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) SP100 Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator [GO:0030330]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" "chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" HAPMTSR 1 1.5 0.91296 -0.32242 0 0 2.99812 0 0 0 7.89105 0 0 0 0 0 P23508 CRCM_HUMAN Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] DYIQQLKNDR;ISFQDFTR;LQGTTIREEDEYSELRSELSQSQHEVNEDSR;MAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEER;MSMLVGK;QLNMEESVAEIMNQLGADENGK;SNAERMSMLVGK 7 11.9 0.97634 -2.2624 11.372 0 14.4087 7.07039 0 6.89966 9.2681 6.84134 9.48162 0 0 0 P23511 NFYA_HUMAN Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) NFYA Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; transcription by RNA polymerase II [GO:0006366] CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LEAEGKIPKER 1 3.2 0.76493 0.063668 0 0 0 0 0 0 0 0 0 8.39305 0 0 P23515 OMGP_HUMAN Oligodendrocyte-myelin glycoprotein OMG OMGP Homo sapiens (Human) cell adhesion [GO:0007155]; neuron projection regeneration [GO:0031102] plasma membrane [GO:0005886]; side of membrane [GO:0098552] NMLEKVVLIK 1 2.3 0.88884 -0.18425 0 0 0 0 0 9.88542 0 0 0 0 0 0 P23526 SAHH_HUMAN Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) AHCY SAHH Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; nucleus [GO:0005634] adenosylhomocysteinase activity [GO:0004013] AGIPVYAWK;ALDIAENEMPGLMR;ATDVMIAGK;GISEETTTGVHNLYK;KLDEAVAEAHLGK;RATDVMIAGK;SDKLPYK;VADIGLAAWGR;VAVVAGYGDVGK;VPAINVNDSVTK;YPQLLPGIR 11 25.9 0 14.439 13.7793 13.3937 13.0959 11.5132 10.6091 0 11.707 11.8188 9.67663 12.9513 11.8984 0 P23528 COF1_HUMAN "Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)" CFL1 CFL Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; cytoskeleton organization [GO:0007010]; establishment of spindle localization [GO:0051293]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; positive regulation by host of viral process [GO:0044794]; positive regulation of embryonic development [GO:0040019]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] actin filament binding [GO:0051015] ASGVAVSDGVIK;ASGVAVSDGVIKVFNDMK;DCRYALYDATYETKESK;EDLVFIFWAPESAPLK;KSSTPEEVK;LGGSAVISLEGKPL;MIYASSK;SSTPEEVK;SSTPEEVKK;YALYDATYETK 10 49.4 0 70.011 14.3745 14.1478 14.2102 11.4043 11.3524 12.0366 13.7397 13.1824 12.733 12.8166 14.2863 11.8043 P23560 BDNF_HUMAN Neurotrophic factor BDNF precursor form (proBDNF) (Abrineurin) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF] BDNF Homo sapiens (Human) axon guidance [GO:0007411]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; collateral sprouting [GO:0048668]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor binding [GO:1900122]; positive regulation of synapse assembly [GO:0051965]; regulation of protein localization to cell surface [GO:2000008]; synapse assembly [GO:0007416] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021] growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163] EANIRGQGGLAYPGVR;IGWRFIR;NYLDAANMSMRVR;SAGRCGKFHQVR 4 17.4 0.9798 -1.8573 10.3187 0 0 0 0 0 0 0 10.6381 0 10.4799 0 P23588 IF4B_HUMAN Eukaryotic translation initiation factor 4B (eIF-4B) EIF4B Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] AASIFGGAKPVDTAAR;APPIDRSILPTAPRAAR;DGYRDGYRDGPR;GLNSLGNRRIR;SWSSRDDYSRDDYR 5 12.2 0.97318 -1.3732 0 8.87765 11.7923 0 9.21898 0 0 8.62059 0 0 0 0 P23634 AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) ATP2B4 ATP2B2 MXRA1 Homo sapiens (Human) calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832] basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080] MVTGDNINTAR;QDYQAVRNEVPEEKLYK;SMSTVIR 3 2.8 0.93661 -0.52332 0 0 0 0 0 0 0 9.38092 0 8.94465 0 11.3701 P23677 IP3KA_HUMAN "Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)" ITPKA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to calcium ion [GO:0071277]; dendritic spine maintenance [GO:0097062]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; modification of postsynaptic actin cytoskeleton [GO:0098885]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of synaptic plasticity [GO:0048167]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic actin cytoskeleton [GO:0098871] "ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; small GTPase binding [GO:0031267]" RCSEPER 1 1.5 0.93331 -0.50042 0 0 8.89878 0 0 0 0 0 0 0 0 0 P23743 DGKA_HUMAN Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (EC 2.7.1.93) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha) DGKA DAGK DAGK1 Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543] DVVCLNDVSCYFSLLEGGRPEDK;FQYILNPRQVFNLLK;IILQMMR;IYLEVDNVPR;LEVVGLEGAIEMGQIYTKLK 5 10.2 0.97839 -1.5083 0 0 8.78503 11.3655 6.01576 0 0 0 12.7867 7.51001 10.1178 0 P23743 DGKA_HUMAN Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (EC 2.7.1.93) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha) DGKA DAGK DAGK1 Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543] DVVCLNDVSCYFSLLEGGRPEDK;IILQMMR;IYLEVDNVPR;QGLSCNRPITCVGAR 4 22.3 0.78316 0.026384 0 0 0 0 7.3267 0 0 0 0 0 0 0 P23759 PAX7_HUMAN Paired box protein Pax-7 (HuP1) PAX7 HUP1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle satellite cell differentiation [GO:0014816] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SRTTFTAEQLEELEK 1 3 0.98037 -1.601 0 8.7791 0 0 0 0 0 0 0 0 0 0 P23760 PAX3_HUMAN Paired box protein Pax-3 (HuP2) PAX3 HUP2 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" TTFTAEQLEELERAFER;VTTPDVEKKIEEYK 2 6.4 0.98024 -1.5605 9.12197 0 0 0 0 0 0 0 0 4.86542 0 0 P23771 GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) GATA3 Homo sapiens (Human) anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cardiac right ventricle morphogenesis [GO:0003215]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell population proliferation [GO:0008283]; cellular response to BMP stimulus [GO:0071773]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; defense response [GO:0006952]; developmental growth [GO:0048589]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; humoral immune response [GO:0006959]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; macrophage differentiation [GO:0030225]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine production [GO:0001817]; regulation of epithelial cell differentiation [GO:0030856]; regulation of establishment of cell polarity [GO:2000114]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of T-helper cell differentiation [GO:0045622]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; transcription by RNA polymerase II [GO:0006366]; type IV hypersensitivity [GO:0001806]; ureter maturation [GO:0035799]; ureter morphogenesis [GO:0072197]; ureteric bud formation [GO:0060676]; uterus development [GO:0060065]; ventricular septum development [GO:0003281] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone methyltransferase binding [GO:1990226]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; interleukin-2 receptor binding [GO:0005134]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" EVTADQPR 1 1.8 0.93645 -0.5485 0 0 10.9473 0 0 0 0 0 0 0 0 0 P23786 CPT2_HUMAN "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" CPT2 CPT1 Homo sapiens (Human) carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; in utero embryonic development [GO:0001701]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of cold-induced thermogenesis [GO:0120162] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] acyltransferase activity [GO:0016746]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine O-palmitoyltransferase activity [GO:0004095] FDATMKTLTIDCVQFQR;QKLMSSGNEESLR 2 4.6 0.94173 -0.61675 0 0 0 0 0 0 0 11.0656 0 0 8.29066 0 P23921 RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) RRM1 RR1 Homo sapiens (Human) 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; male gonad development [GO:0008584]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041]; ribonucleoside diphosphate metabolic process [GO:0009185] cell projection [GO:0042995]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971] "ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity [GO:0061731]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" HSPMVAK 1 0.9 0.94039 -0.58436 0 0 0 0 0 0 0 0 0 12.9105 0 0 P23945 FSHR_HUMAN Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) FSHR LGR1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; female gamete generation [GO:0007292]; female gonad development [GO:0008585]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; gonad development [GO:0008406]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528] CGCYEMQAQIYR;TETSSTVHNTHPR 2 3.6 0.78111 0.021565 0 0 0 0 5.98071 5.69588 0 0 0 0 0 0 P23946 CMA1_HUMAN Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I) CMA1 CYH CYM Homo sapiens (Human) angiotensin maturation [GO:0002003]; basement membrane disassembly [GO:0034769]; cellular response to glucose stimulus [GO:0071333]; cytokine precursor processing [GO:0140447]; extracellular matrix disassembly [GO:0022617]; midbrain development [GO:0030901]; peptide metabolic process [GO:0006518]; positive regulation of angiogenesis [GO:0045766]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; regulation of inflammatory response [GO:0050727] collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] endopeptidase activity [GO:0004175]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LEVIKQFRHPK 1 4.5 0.86505 -0.089504 0 0 10.4322 0 0 0 0 0 0 0 0 0 P23975 SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) SLC6A2 NAT1 NET1 SLC6A5 Homo sapiens (Human) amino acid transport [GO:0006865]; chemical synaptic transmission [GO:0007268]; dopamine uptake involved in synaptic transmission [GO:0051583]; monoamine transport [GO:0015844]; neuron cellular homeostasis [GO:0070050]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; cell surface [GO:0009986]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dopamine:sodium symporter activity [GO:0005330]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; neurotransmitter:sodium symporter activity [GO:0005328]; norepinephrine:sodium symporter activity [GO:0005334] ERNGVQCLLAPR;FDNNCYR 2 3.1 0.95223 -0.77029 0 6.38083 0 0 0 0 8.67101 0 0 0 0 0 P24043 LAMA2_HUMAN Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) LAMA2 LAMM Homo sapiens (Human) "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; maintenance of blood-brain barrier [GO:0035633]; muscle organ development [GO:0007517]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; Schwann cell differentiation [GO:0014037]" basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; sarcolemma [GO:0042383]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] CNAGGSFSEVCHSQTGQCECR;CSCSDQTGQCTCK;CTACPRGYEGQYCER;DISVGGMCICYGHAR;DLRDFMSVELTDGHIK;ELINQARK;INDGQWHKIK;IYFGGLPTLRNLSMK;LFAVNQKNMTALEKK;NLSMKARPEVNLKK;PGAAGVLLLLLLSGGLGGVQAQRPQQQR;QANSIKVSVSSGGDCIRTYKPEIK;RNLSLNIR;SRCECEHNTCGDSCDQCCPGFHQKPWR;TEAESGLLFYMAR;TNTRAKSLGEFIK 16 8 0.97669 -2.2441 9.22258 11.6762 5.16491 0 0 9.36126 12.4928 9.04169 8.69669 0 8.42105 11.5349 P24071 FCAR_HUMAN Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89) FCAR CD89 Homo sapiens (Human) cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; Fc receptor signaling pathway [GO:0038093]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of neutrophil apoptotic process [GO:0033031] extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] IgA binding [GO:0019862]; IgA receptor activity [GO:0019766] IQAQEGR 1 2.4 0.91727 -0.4127 9.50299 0 0 0 0 0 0 8.74796 9.05796 0 0 0 P24158 PRTN3_HUMAN Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen) PRTN3 MBN Homo sapiens (Human) antimicrobial humoral response [GO:0019730]; cell-cell junction maintenance [GO:0045217]; collagen catabolic process [GO:0030574]; mature conventional dendritic cell differentiation [GO:0097029]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of phagocytosis [GO:0050765]; neutrophil extravasation [GO:0072672]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] enzyme binding [GO:0019899]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102] LFPDFFTRVALYVDWIR 1 6.6 0.92066 -0.43888 0 0 0 0 0 0 0 0 11.1969 0 0 0 P24347 MMP11_HUMAN Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) MMP11 STMY3 Homo sapiens (Human) basement membrane organization [GO:0071711]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of fat cell differentiation [GO:0045599]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] FPVHAALVWGPEK;GGQLQPGYPALASR 2 5.5 0.92887 -0.46211 0 0 0 0 0 7.72683 0 0 0 0 0 7.58286 P24386 RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) CHM REP1 TCD Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267] ENHCDDK;FLTFCMEYEK;YPDEYKGYEEITFYEYLKTQK 3 5.8 0.91832 -0.40393 8.79214 6.45378 0 0 0 6.87553 0 0 0 0 0 0 P24390 ERD21_HUMAN ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23) KDELR1 ERD2.1 Homo sapiens (Human) "protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]" cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] FLGDLSHLLAIILLLLK;NLFRFLGDLSHLLAIILLLLKIWK 2 11.3 0.17862 0.33942 0 8.65668 0 0 0 0 0 0 0 0 0 0 P24462 CP3A7_HUMAN Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) CYP3A7 Homo sapiens (Human) estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] "all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]" DNIDPYIYTPFGSGPR;VFPFLTPILEALNITVFPRK 2 6.7 0.9088 -0.27792 0 0 0 8.68545 0 0 0 0 0 0 0 0 P24468 COT2_HUMAN COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) NR2F2 ARP1 TFCOUP2 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; fertilization [GO:0009566]; forebrain development [GO:0030900]; interneuron migration [GO:1904936]; lymphatic endothelial cell fate commitment [GO:0060838]; maternal placenta development [GO:0001893]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; placenta blood vessel development [GO:0060674]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; radial pattern formation [GO:0009956]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; skeletal muscle tissue development [GO:0007519]; trophoblast giant cell differentiation [GO:0060707] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] AMVVSTWR;HYGQFTCEGCKSFFK;SVRRNLSYTCR 3 8.2 0.93588 -0.53718 12.4185 0 0 0 0 0 0 0 3.15014 0 0 6.74012 P24522 GA45A_HUMAN Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) GADD45A DDIT1 GADD45 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; signal transduction in response to DNA damage [GO:0042770] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] kinase binding [GO:0019900]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] MTLEEFSAGEQK;TLEEFSAGEQKTER 2 9.1 0.94209 -0.61733 10.5329 0 0 0 0 0 0 0 0 0 0 9.86338 P24530 EDNRB_HUMAN Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB ETRB Homo sapiens (Human) aldosterone metabolic process [GO:0032341]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cGMP-mediated signaling [GO:0019934]; chordate pharynx development [GO:0160093]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; enteric nervous system development [GO:0048484]; enteric smooth muscle cell differentiation [GO:0035645]; epithelial fluid transport [GO:0042045]; establishment of endothelial barrier [GO:0061028]; gene expression [GO:0010467]; heparin metabolic process [GO:0030202]; macrophage chemotaxis [GO:0048246]; melanocyte differentiation [GO:0030318]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron maturation [GO:0014043]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast migration [GO:0097402]; peripheral nervous system development [GO:0007422]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte differentiation [GO:0072112]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of penile erection [GO:0060406]; positive regulation of urine volume [GO:0035810]; posterior midgut development [GO:0007497]; protein transmembrane transport [GO:0071806]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fever generation [GO:0031620]; regulation of heart rate [GO:0002027]; regulation of pH [GO:0006885]; renal albumin absorption [GO:0097018]; renal sodium excretion [GO:0035812]; renal sodium ion absorption [GO:0070294]; renin secretion into blood stream [GO:0002001]; response to endothelin [GO:1990839]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to sodium phosphate [GO:1904383]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]; vein smooth muscle contraction [GO:0014826] nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962]; peptide hormone binding [GO:0017046]; type 1 angiotensin receptor binding [GO:0031702] IIYKNKCMR;QPPPSLCGR 2 4.1 0.96673 -1.278 0 0 0 9.38653 0 0 0 0 10.4793 0 0 0 P24534 EF1B_HUMAN Elongation factor 1-beta (EF-1-beta) EEF1B2 EEF1B EF1B Homo sapiens (Human) response to ethanol [GO:0045471]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853] guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746] ASLPGVK;LVPVGYGIK;SIQADGLVWGSSK 3 12.9 0 2.7586 13.0096 0 12.6048 0 0 10.3821 0 10.1965 0 10.0827 10.8751 0 P24539 AT5F1_HUMAN "ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)" ATP5PB ATP5F1 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762] "membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] ETIAKCIADLK;SQQALVQK 2 7.4 0.95198 -0.74601 0 0 0 0 0 0 0 0 11.3373 0 0 0 P24557 THAS_HUMAN Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) TBXAS1 CYP5 CYP5A1 TXAS Homo sapiens (Human) cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; intracellular chloride ion homeostasis [GO:0030644]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; thromboxane-A synthase activity [GO:0004796]" DFLQMVLDAR;FTAEARQQHRPFTYLPFGAGPR;LGLLEVKLTLLHVLHK;WEEVRGALMSAFSPEK 4 12 0.98214 -1.5867 8.14221 0 0 8.81823 0 0 0 0 0 9.52264 0 0 P24593 IBP5_HUMAN Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) IGFBP5 IBP5 Homo sapiens (Human) cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; lung alveolus development [GO:0048286]; mammary gland involution [GO:0060056]; negative regulation of cell migration [GO:0030336]; negative regulation of growth [GO:0045926]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of skeletal muscle hypertrophy [GO:1904205]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell growth [GO:0001558]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to growth hormone [GO:0060416]; signal transduction [GO:0007165]; striated muscle cell differentiation [GO:0051146]; type B pancreatic cell proliferation [GO:0044342] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634] fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; receptor ligand activity [GO:0048018] GICWCVDKYGMK 1 4.4 0.83697 -0.030494 0 0 0 0 0 0 0 0 0 0 0 6.41616 P24666 PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) ACP1 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; sarcolemma [GO:0042383] "acid phosphatase activity [GO:0003993]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" QITKEDFATFDYILCMDESNLR;SPIAEAVFR 2 19.6 0.013699 0.7768 11.9605 0 4.42553 0 0 0 0 11.6028 0 0 9.45804 0 P24723 KPCL_HUMAN Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) PRKCH PKCL PRKCL Homo sapiens (Human) cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]" FMATYLR;GIIYRDLK;QGKESSK;TLAGMGLQPGNISPTSKLVSR 4 6.3 0.93652 -0.54722 0 11.3725 0 0 0 7.31723 0 0 0 0 0 0 P24752 THIL_HUMAN "Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)" ACAT1 ACAT MAT Homo sapiens (Human) acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; isoleucine catabolic process [GO:0006550]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955] LNIARNEQDAYAINSYTRSK;LNVTPLAR;NEQDAYAINSYTR;TPIGSFLGSLSLLPATK;VCASGMK;VNINGGAVSLGHPIGMSGAR 6 16.9 0 103.28 10.0229 9.3692 10.568 0 0 8.9289 11.2467 7.98624 8.20755 0 10.252 0 P24821 TENA_HUMAN Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC HXB Homo sapiens (Human) bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; interstitial matrix [GO:0005614]; membrane [GO:0016020]; perisynaptic extracellular matrix [GO:0098966]; tenascin complex [GO:0090733] extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; syndecan binding [GO:0045545] CECDDGFTGADCGELKCPNGCSGHGR;CVNGMCVCDDGYTGEDCR;ITYVPITGGTPSMVTVDGTK;SIPVSAR;VSQTDNSITLEWRNGK 5 4 0.93327 -0.51364 0 0 0 0 4.56657 0 10.9534 9.40667 9.12309 0 7.60748 0 P24844 MYL9_HUMAN "Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)" MYL9 MLC2 MRLC1 MYRL2 Homo sapiens (Human) myofibril assembly [GO:0030239]; platelet aggregation [GO:0070527]; regulation of muscle contraction [GO:0006937]; stress fiber assembly [GO:0043149] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; stress fiber [GO:0001725]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] ELLTTMGDR;LNGTDPEDVIR;TTKKRPQR 3 16.3 0.012422 0.88796 0 10.6235 0 0 0 9.77288 0 0 0 11.0296 0 0 P24864 CCNE1_HUMAN G1/S-specific cyclin-E1 CCNE1 CCNE Homo sapiens (Human) cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; protein phosphorylation [GO:0006468]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723]; Wnt signaling pathway [GO:0016055] cyclin E1-CDK2 complex [GO:0097134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901] DQCGSQPWDNNAVCADPCSLIPTPDK 1 6.3 0.71159 0.14778 0 0 0 0 0 0 0 0 0 7.44352 0 0 P24903 CP2F1_HUMAN Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1) CYP2F1 Homo sapiens (Human) epoxygenase P450 pathway [GO:0019373]; naphthalene catabolic process [GO:1901170]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]" DSISTAILLLLLALVCLLLTLSSR 1 4.9 0.7103 0.15634 0 0 4.13266 0 0 0 0 0 0 0 0 0 P24928 RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) DNA-templated transcription termination [GO:0006353]; positive regulation of RNA splicing [GO:0033120]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366] "chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; kinase binding [GO:0019900]; magnesium ion binding [GO:0000287]; microfibril binding [GO:0050436]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; RNA-dependent RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] DDYGPESR;LGGLMDPRQGVIERTGR;LLVDSNNPK;SLSEYNNFK;TLPHFIK;TPSLTVFLLGQSAR;VLSEKDVDPVR 7 3.8 0.9789 -1.9591 13.196 0 0 0 10.4543 0 9.70453 11.6482 0 9.54564 0 0 P25025 CXCR2_HUMAN C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) CXCR2 IL8RB Homo sapiens (Human) acute inflammatory response to antigenic stimulus [GO:0002438]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-8-mediated signaling pathway [GO:0038112]; metanephric tubule morphogenesis [GO:0072173]; midbrain development [GO:0030901]; negative regulation of neutrophil apoptotic process [GO:0033030]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular permeability [GO:0043117]; receptor internalization [GO:0031623]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mast cell granule [GO:0042629]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918] RYLVKFICLSIWGLSLLLALPVLLFR 1 7.2 0.6838 0.16504 0 0 0 0 0 0 0 0 0 0 0 5.54757 P25054 APC_HUMAN Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) APC DP2.5 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; endocardial cushion morphogenesis [GO:0003203]; heart valve development [GO:0003170]; insulin receptor signaling pathway [GO:0008286]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of pseudopodium assembly [GO:0031274]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of microtubule-based movement [GO:0060632]; regulation of microtubule-based process [GO:0032886]; Wnt signaling pathway [GO:0016055] adherens junction [GO:0005912]; beta-catenin destruction complex [GO:0030877]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; Wnt signalosome [GO:1990909] beta-catenin binding [GO:0008013]; dynein complex binding [GO:0070840]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin protein ligase binding [GO:0031625] AYCETCWEWQEAHEPGMDQDK;DSKDNQAK;EHSKHSSSLPR;GANGSETNR;HSSPSGTVAAR;HVDQPIDYSLK;LPPPVARKPSQLPVYK;NLIHSKHK;QLEYEARQIR;SPTGNTPPVIDSVSEKANPNIK;VELSRMSSTKSSGSESDR 11 5.1 0.97823 -7.1346 0 0 5.48983 9.32166 10.371 4.88996 9.64503 0 11.2733 0 10.2913 0 P25067 CO8A2_HUMAN Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell-cell adhesion [GO:0098609]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674] ASSGGGAGGAAGYAPVK 1 2.4 0.0085106 0.9738 0 0 9.54697 10.2623 10.4192 0 0 0 0 0 0 0 P25090 FPR2_HUMAN N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP) FPR2 FPRH1 FPRL1 LXA4R Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of inflammatory response [GO:0050728]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of innate immune response [GO:0045089]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898] cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]; scavenger receptor binding [GO:0005124]; signaling receptor activity [GO:0038023] VLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGK 1 10 0.88805 -0.19984 0 0 8.74732 0 0 0 0 0 0 0 0 0 P25092 GUC2C_HUMAN Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase) GUCY2C GUC2C STAR Homo sapiens (Human) cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of cell population proliferation [GO:0042127]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; toxic substance binding [GO:0015643] LLQIDYYNLTK;NCWEEDPEK 2 1.9 0.88122 -0.15317 0 0 3.80952 0 0 0 10.593 0 0 0 0 0 P25098 ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) GRK2 ADRBK1 BARK BARK1 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; negative regulation of relaxation of smooth muscle [GO:1901081]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; regulation of the force of heart contraction [GO:0002026]; symbiont entry into host cell [GO:0046718]; tachykinin receptor signaling pathway [GO:0007217]; viral genome replication [GO:0019079] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672] KADTGKMYAMK;LLDSDQELYR;MGNPFLTQWQR;SLLEGLLQRDVNR 4 6.5 0.97335 -2.8898 0 0 9.54697 0 0 0 0 0 11.0949 0 0 0 P25101 EDNRA_HUMAN Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) EDNRA ETA ETRA Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; artery smooth muscle contraction [GO:0014824]; atrial cardiac muscle tissue development [GO:0003228]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; cAMP/PKA signal transduction [GO:0141156]; canonical Wnt signaling pathway [GO:0060070]; cardiac chamber formation [GO:0003207]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell population proliferation [GO:0008283]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to oxidative stress [GO:0034599]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; embryonic heart tube development [GO:0035050]; embryonic skeletal system development [GO:0048706]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; enteric nervous system development [GO:0048484]; establishment of endothelial barrier [GO:0061028]; face development [GO:0060324]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; heparin metabolic process [GO:0030202]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; mesenchymal cell apoptotic process [GO:0097152]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; neural crest cell fate commitment [GO:0014034]; neuromuscular process [GO:0050905]; neuron remodeling [GO:0016322]; noradrenergic neuron differentiation [GO:0003357]; norepinephrine metabolic process [GO:0042415]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte apoptotic process [GO:1903210]; podocyte differentiation [GO:0072112]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein transmembrane transport [GO:0071806]; regulation of blood pressure [GO:0008217]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of heart rate [GO:0002027]; regulation of protein localization to cell leading edge [GO:1905871]; renal albumin absorption [GO:0097018]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to acetylcholine [GO:1905144]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; sodium ion homeostasis [GO:0055078]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; vascular associated smooth muscle cell development [GO:0097084]; vasoconstriction [GO:0042310] plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962]; phosphatidylinositol phospholipase C activity [GO:0004435] FKNCFQSCLCCCCYQSK;NCFQSCLCCCCYQSK 2 4 0.96558 -1.1453 0 0 0 0 0 0 3.73205 0 0 0 0 0 P25103 NK1R_HUMAN Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 NK1R TAC1R Homo sapiens (Human) "aggressive behavior [GO:0002118]; angiotensin-mediated drinking behavior [GO:0003051]; associative learning [GO:0008306]; behavioral response to pain [GO:0048266]; detection of abiotic stimulus [GO:0009582]; eating behavior [GO:0042755]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of action potential [GO:0045760]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of ossification [GO:0045778]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasoconstriction [GO:0045907]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell proliferation [GO:0048660]; response to auditory stimulus [GO:0010996]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to progesterone [GO:0032570]; smooth muscle contraction involved in micturition [GO:0060083]; sperm ejaculation [GO:0042713]; tachykinin receptor signaling pathway [GO:0007217]" cell body [GO:0044297]; cell surface [GO:0009986]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225] substance P receptor activity [GO:0016496]; tachykinin receptor activity [GO:0004995] LGFKHAFR 1 2 0.97975 -1.565 0 0 0 0 11.6144 0 0 0 0 0 0 0 P25116 PAR1_HUMAN Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) F2R CF2R PAR1 TR Homo sapiens (Human) "anatomical structure morphogenesis [GO:0009653]; cell-cell junction maintenance [GO:0045217]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; dendritic cell homeostasis [GO:0036145]; establishment of synaptic specificity at neuromuscular junction [GO:0007529]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of renin secretion into blood stream [GO:1900134]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; regulation of blood coagulation [GO:0030193]; regulation of interleukin-1 beta production [GO:0032651]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; thrombin-activated receptor signaling pathway [GO:0070493]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" caveola [GO:0005901]; cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; platelet dense tubular network [GO:0031094]; postsynaptic membrane [GO:0045211] G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057] RPESKATNATLDPR 1 3.3 0.95193 -0.69461 0 0 0 0 0 0 0 0 0 0 0 11.5073 P25189 MYP0_HUMAN Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero) MPZ Homo sapiens (Human) cell aggregation [GO:0098743]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; chemical synaptic transmission [GO:0007268]; myelination [GO:0042552] myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202] structural molecule activity [GO:0005198] NPPDIVGKTSQVTLYVFEK;VMVIEMELRK 2 9.3 0.70852 0.15815 5.94441 0 5.50013 0 0 0 0 0 0 0 4.50329 0 P25205 MCM3_HUMAN DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) MCM3 Homo sapiens (Human) DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174] "alpha DNA polymerase:primase complex [GO:0005658]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] AGTVVLDDVELR;ELISDNQYR;LTESINR;TRSKDIFDQLAK;TSPVTAR;VQVVGTYR;YVLCTAPR 7 7.8 0 10.203 10.4968 12.4362 0 9.25908 9.36137 9.36696 10.4833 0 11.123 11.7891 12.3808 0 P25208 NFYB_HUMAN Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) NFYB HAP3 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EQDIYLPIANVAR 1 6.3 0.89662 -0.23646 0 0 0 0 0 0 0 0 0 0 0 8.11884 P25325 THTM_HUMAN 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) MPST TST2 Homo sapiens (Human) cyanate catabolic process [GO:0009440]; hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; response to toxic substance [GO:0009636]; spinal cord development [GO:0021510]; sulfur amino acid catabolic process [GO:0000098]; transsulfuration [GO:0019346] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synapse [GO:0045202] 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate sulfurtransferase activity [GO:0004792] TYEDIKENLESRR 1 4.4 0.86881 -0.091465 0 0 0 0 0 0 0 0 7.29444 0 0 0 P25391 LAMA1_HUMAN Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) LAMA1 LAMA Homo sapiens (Human) branching involved in salivary gland morphogenesis [GO:0060445]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retinal blood vessel morphogenesis [GO:0061304] basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102] AKDCYYDESVAK;ISDISMEVGRKAEK;KLTRMLASTQK;LVPENFQDFHSKR 4 1.6 0.97905 -1.9009 0 3.5735 0 0 0 0 0 0 0 0 9.66631 11.8036 P25398 RS12_HUMAN Small ribosomal subunit protein eS12 (40S ribosomal protein S12) RPS12 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AEEGIAAGGVMDVNTALQEVLK;DVIEEYFK;LGEWVGLCK;LGEWVGLCKIDREGKPR;TALIHDGLAR 5 43.2 0 44.611 0 3.80333 13.2827 6.28036 8.72901 9.52337 10.2491 9.68911 9.85297 9.56845 0 10.3498 P25440 BRD2_HUMAN Bromodomain-containing protein 2 (O27.1.1) BRD2 KIAA9001 RING3 Homo sapiens (Human) chromatin looping [GO:0140588]; chromatin remodeling [GO:0006338]; neural tube closure [GO:0001843]; nucleosome assembly [GO:0006334]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; protein localization to chromatin [GO:0071168]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetylation-dependent protein binding [GO:0140033]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674] AGADEDDKGPR;AGADEDDKGPRAPRPPQPK;ELERYVLSCLR;LPPMRRESGRPIKPPR;LSEQLKHCNGILK;QPVDAVK 6 8.2 0.96375 -1.2027 12.3498 0 0 0 0 8.69366 0 12.5613 10.6575 8.97057 5.77774 11.2238 P25445 TNR6_HUMAN Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) FAS APT1 FAS1 TNFRSF6 Homo sapiens (Human) activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to hyperoxia [GO:0071455]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; immune response [GO:0006955]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165] CD95 death-inducing signaling complex [GO:0031265]; cell surface [GO:0009986]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031] KNGVNEAK;NWHQLHGKK;SNLGWLCLLLLPIPLIVWVKRK;VQLLRNWHQLHGKK 4 13.1 0.2689 0.25955 7.13473 5.92075 0 0 6.30342 0 8.6945 0 10.088 0 0 6.48999 P25685 DNJB1_HUMAN DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) DNAJB1 DNAJ1 HDJ1 HSPF1 Homo sapiens (Human) cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; forebrain development [GO:0030900]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sperm head [GO:0061827] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; unfolded protein binding [GO:0051082] DGSDVIYPAR;TVLEQVLPI 2 5.6 0 2.1114 0 0 0 0 0 0 9.67444 0 9.40844 0 11.3328 0 P25705 ATPA_HUMAN "ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)" ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nitric oxide [GO:0071732]; lipid metabolic process [GO:0006629]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to muscle activity [GO:0014850] "cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "ADP binding [GO:0043531]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]" APGIIPR;AVDSLVPIGR;EAYPGDVFYLHSR;ELIIGDR;EPMQTGIK;FNDGSDEK;ILGADTSVDLEETGR;LKEIVTNFLAGFEA;QMSLLLR;TGAIVDVPVGEELLGR;TGTAEMSSILEER;TSIAIDTIINQK;VLSIGDGIAR 13 25.3 0 48.613 14.6956 14.4382 13.8975 9.85669 10.0932 9.65211 13.1219 13.0521 13.8517 12.1811 11.7116 13.4027 P25713 MT3_HUMAN Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III) MT3 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; cellular detoxification [GO:1990748]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; energy reserve metabolic process [GO:0006112]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of oxygen metabolic process [GO:2000376]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein stabilization [GO:0050821]; regulation of response to food [GO:0032095]; removal of superoxide radicals [GO:0019430]; response to hypoxia [GO:0001666]; zinc ion transport [GO:0006829] astrocyte end-foot [GO:0097450]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; inclusion body [GO:0016234]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; synaptic vesicle [GO:0008021] antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; zinc ion binding [GO:0008270] CEGCKCTSCK;DCVCKGGEAAEAEAEKCSCCQ;KSCCSCCPAECEK;SCCSCCPAECEKCAKDCVCK 4 69.1 0.58303 0.17989 6.43645 0 4.30093 0 4.75499 0 7.25588 5.49416 0 0 0 0 P25774 CATS_HUMAN Cathepsin S (EC 3.4.22.27) CTSS Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; basement membrane disassembly [GO:0034769]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cation channel activity [GO:2001259]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to acidic pH [GO:0010447]; toll-like receptor signaling pathway [GO:0002224] collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; tertiary granule lumen [GO:1904724] collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252] HPSFFLYR 1 2.4 0.87874 -0.14057 0 0 0 0 0 0 0 7.88032 0 0 0 0 P25786 PSA1_HUMAN Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) PSMA1 HC2 NU PROS30 PSC2 Homo sapiens (Human) immune system process [GO:0002376]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]" lipopolysaccharide binding [GO:0001530] AMSIGAR;AMSIGARSQSARTYLER;ETLPAEQDLTTK;LLCNFMRQECLDSR;LVSLIGSK;TQIPTQR 6 22.1 0.98123 -1.7765 11.5687 0 8.54728 0 0 0 10.0287 11.6722 8.59552 10.8462 14.2104 0 P25787 PSA2_HUMAN Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2) PSMA2 HC3 PSC3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]" ATAMGKNYVNGK;SILYDER 2 8.1 0.96321 -1.0968 0 6.01705 0 0 0 0 0 0 0 0 0 0 P25788 PSA3_HUMAN Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) PSMA3 HC8 PSC8 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of endopeptidase activity [GO:0052548] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; synapse [GO:0045202]" ubiquitin protein ligase binding [GO:0031625] EEASNFR;EEDESDDDNM;ESLKEEDESDDDNM;LQMKEMTCRDIVK;SLADIAR;SNFGYNIPLK;SSIGTGYDLSASTFSPDGR 7 27.5 0 2.1158 0 0 0 0 0 0 11.6684 0 0 9.50553 10.0063 11.2829 P25789 PSA4_HUMAN Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) PSMA4 HC9 PSC9 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]" SALALAIK;TTIFSPEGR;VLNKTMDVSK 3 10.3 0.70259 0.16034 10.8032 10.8134 0 0 0 0 11.5045 11.5401 11.2161 11.0722 11.286 11.2224 P25815 S100P_HUMAN Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) S100P S100E Homo sapiens (Human) endothelial cell migration [GO:0043542] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; transition metal ion binding [GO:0046914] ELPGFLQSGK;YSGSEGSTQTLTK 2 24.2 0 6.1695 0 0 0 0 0 0 12.6893 12.17 0 10.4756 11.0997 0 P25874 UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) UCP1 SLC25A7 UCP Homo sapiens (Human) adaptive thermogenesis [GO:1990845]; brown fat cell differentiation [GO:0050873]; cellular response to cold [GO:0070417]; cellular response to dehydroepiandrosterone [GO:1903495]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; diet induced thermogenesis [GO:0002024]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667]; response to temperature stimulus [GO:0009266] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] cardiolipin binding [GO:1901612]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; purine ribonucleotide binding [GO:0032555]; transmembrane transporter activity [GO:0022857] QTMDCAT 1 2.3 0.71176 0.15645 0 0 0 5.49118 0 0 0 0 0 0 0 0 P25929 NPY1R_HUMAN Neuropeptide Y receptor type 1 (NPY1-R) NPY1R NPYR NPYY1 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233]" neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601] HQLIINPRGWRPNNR 1 3.9 0.82543 -0.02016 0 0 0 0 6.97453 0 0 0 0 0 0 0 P25940 CO5A3_HUMAN Collagen alpha-3(V) chain COL5A3 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; skin development [GO:0043588] collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; proteoglycan binding [GO:0043394] AAEYPSR;GERGQPGATGQPGPK;GLPGDTGPK;GSPGPTGRPGVTGIDGAPGAK 4 3 0.962 -1.079 0 0 0 0 0 0 0 0 10.4318 0 7.37877 0 P25942 TNR5_HUMAN Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) CD40 TNFRSF5 Homo sapiens (Human) B cell activation [GO:0042113]; B cell mediated immunity [GO:0019724]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to tumor necrosis factor [GO:0071356]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; response to cobalamin [GO:0033590]; response to type II interferon [GO:0034341] CD40 receptor complex [GO:0035631]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; varicosity [GO:0043196] antigen binding [GO:0003823]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625] ALVVIPIIFGILFAILLVLVFIKKVAK;ISVQERQ;LRALVVIPIIFGILFAILLVLVFIKK 3 13 0.85061 -0.075003 0 0 0 0 0 4.32984 0 0 8.66181 0 3.97536 9.92383 P25963 IKBA_HUMAN NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) NFKBIA IKBA MAD3 NFKBI Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cold [GO:0070417]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; interleukin-1-mediated signaling pathway [GO:0070498]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; non-canonical NF-kappaB signal transduction [GO:0038061]; Notch signaling pathway [GO:0007219]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; NF-kappaB binding [GO:0051059]; nuclear localization sequence binding [GO:0008139]; protein sequestering activity [GO:0140311]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625] DEEYEQMVK;LLDDRHDSGLDSMK 2 7.3 0.93347 -0.51009 0 0 0 0 0 0 5.23005 5.9939 0 0 0 0 P26006 ITA3_HUMAN Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] ITGA3 MSK18 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; dendritic spine maintenance [GO:0097062]; exploration behavior [GO:0035640]; heart development [GO:0007507]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lung development [GO:0030324]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; negative regulation of cell projection organization [GO:0031345]; negative regulation of Rho protein signal transduction [GO:0035024]; nephron development [GO:0072006]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of BMP signaling pathway [GO:0030510]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of Wnt signaling pathway [GO:0030111]; renal filtration [GO:0097205]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skin development [GO:0043588]; synaptic membrane adhesion [GO:0099560] basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cell surface [GO:0009986]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone filopodium [GO:1990812]; integrin alpha3-beta1 complex [GO:0034667]; integrin complex [GO:0008305]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]; synaptic membrane [GO:0097060] collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982] CDFFKRTR;KLLLSINVTNTR;NITLAYTLEADRDR;YLLLAGAPR 4 4 0.97241 -2.8102 7.09191 0 0 0 0 0 0 0 9.53238 8.4441 7.2751 0 P26010 ITB7_HUMAN Integrin beta-7 (Gut homing receptor beta subunit) ITGB7 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618] CNRCQCLDGYYGALCDQCPGCKTPCER;GCPLEELEEPR;TGRACECSGDMDSCISPEGGLCSGHGRCK;VALPMVLVLLLVLSRGESELDAK 4 11.3 0.77894 0.0344 0 6.99401 0 0 0 4.00171 0 10.6114 0 0 5.20453 0 P26012 ITB8_HUMAN Integrin beta-8 ITGB8 Homo sapiens (Human) cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; ganglioside metabolic process [GO:0001573]; hard palate development [GO:0060022]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; negative regulation of gene expression [GO:0010629]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; response to virus [GO:0009615]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] extracellular matrix protein binding [GO:1990430]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] KDKLILQSVCTR;LIDNNINVIFAVQGKQFHWYK;LLLVMTDQTSHLALDSK;LNAHETFR;VLIIRQVILQWNSNK;VLIIRQVILQWNSNKIK 6 9.8 0.98037 -1.8139 0 0 0 14.5307 0 8.47001 9.36148 14.7135 14.5913 17.419 0 12.9332 P26022 PTX3_HUMAN Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14) PTX3 TNFAIP5 TSG14 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation by host of viral process [GO:0044793]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of viral entry into host cell [GO:0046597]; opsonization [GO:0008228]; ovarian cumulus expansion [GO:0001550]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; response to yeast [GO:0001878] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] (1->3)-beta-D-glucan binding [GO:0001872]; complement component C1q complex binding [GO:0001849]; identical protein binding [GO:0042802]; virion binding [GO:0046790] TILFSYGTK 1 2.4 0.90736 -0.30714 0 0 11.8148 0 0 0 0 0 0 0 0 0 P26038 MOES_HUMAN Moesin (Membrane-organizing extension spike protein) MSN Homo sapiens (Human) cellular response to testosterone stimulus [GO:0071394]; establishment of endothelial barrier [GO:0061028]; establishment of epithelial cell apical/basal polarity [GO:0045198]; gland morphogenesis [GO:0022612]; immunological synapse formation [GO:0001771]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]; T cell aggregation [GO:0070489]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; uropod [GO:0001931]; vesicle [GO:0031982] actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200] ALELEQER;ALTSELANAR;ALTSELANARDESK;AMLENEK;APDFVFYAPR;AQMVQEDLEK;AQQELEEQTR;AQQELEEQTRR;DQKKTQEQLALEMAELTAR;EALLQASR;ESEAVEWQQK;ESPLLFK;FVIKPIDK;IGFPWSEIR;ISQLEMAR;KPDTIEVQQMK;NISFNDKK;QIEEQTK;QLFDQVVK;QRIDEFESM;RKPDTIEVQQMK;TANDMIHAENMR;TQEQLALEMAELTAR;TTEAEKNER;VTAQDVR;VTTMDAELEFAIQPNTTGK 26 38.1 0 23.411 0 11.7295 0 4.68094 0 0 13.4348 12.793 11.2324 14.5175 14.2503 12.0299 P26045 PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) PTPN3 PTPH1 Homo sapiens (Human) liver regeneration [GO:0097421]; MAPK cascade [GO:0000165]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of mitotic cell cycle [GO:0045930]; protein dephosphorylation [GO:0006470]; regulation of membrane depolarization during action potential [GO:0098902]; regulation of sodium ion transmembrane transporter activity [GO:2000649] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] "ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; sodium channel regulator activity [GO:0017080]" KPGLAITFAKLPQNLDK;SCKNLWK 2 2.6 0.98109 -1.7529 0 0 0 3.95717 0 0 0 0 0 0 0 0 P26232 CTNA2_HUMAN Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) CTNNA2 CAPR Homo sapiens (Human) axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; dendrite morphogenesis [GO:0048813]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; prepulse inhibition [GO:0060134]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of synapse structural plasticity [GO:0051823] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200] IILDPMTFSEAR;LDAEVAK;LESIISGAALMADSSCTR;LLEPLVTQVTTLVNTSNK;LVYDGVRDIR 5 6.8 0 3.0047 11.9832 0 0 0 0 8.6675 12.226 0 0 0 0 0 P26358 DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) DNMT1 AIM CXXC9 DNMT Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; epigenetic programming of gene expression [GO:0043045]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; positive regulation of gene expression [GO:0010628]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707] female germ cell nucleus [GO:0001674]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; replication fork [GO:0005657] "DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; lncRNA binding [GO:0106222]; methyl-CpG binding [GO:0008327]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270]" DLPNIEVR;DSLTEKECVKEK;LTCFSVYCK;LTLRCLVR;LVYQIFDTFFAEQIEK;QACQERRCPNMAMK;QFNTLIPWCLPHTGNR;QLRGAQYQPILRDHICK;SMVLKLTLRCLVR;VARPLPAEEPER 10 7.2 0.9725 -2.602 7.07938 0 0 9.37393 0 9.35988 0 8.13 0 11.3356 11.8213 0 P26367 PAX6_HUMAN Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin) PAX6 AN2 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; brain development [GO:0007420]; cell fate determination [GO:0001709]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; cerebellum development [GO:0021549]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; establishment of mitotic spindle orientation [GO:0000132]; eye development [GO:0001654]; eye photoreceptor cell development [GO:0042462]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pancreatic A cell development [GO:0003322]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regulation of asymmetric cell division [GO:0009786]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; sensory organ development [GO:0007423]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]; visual perception [GO:0007601] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]" ILGRYYETGSIRPRAIGGSKPR 1 5.2 0.56142 0.18276 0 0 0 0 0 0 0 0 0 0 5.7362 0 P26368 U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) U2AF2 U2AF65 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]; spliceosomal complex assembly [GO:0000245]" commitment complex [GO:0000243]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701] C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; molecular function inhibitor activity [GO:0140678]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723] AMQGLTGR;SDFDEFER 2 3.4 0.0045249 1.2097 0 0 0 0 0 0 0 0 0 8.97799 8.85078 0 P26373 RL13_HUMAN Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) RPL13 BBC1 OK/SW-cl.46 Homo sapiens (Human) blastocyst development [GO:0001824]; bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AKEAAEQDVEK;EAAEQDVEK;LATQLTGPVMPVR;STESLQANVQR;TIGISVDPR;VARTIGISVDPR;VATWFNQPAR;VITEEEK;VITEEEKNFK 9 31.8 0 33.239 12.7054 13.6641 13.6668 9.71677 10.0579 10.3883 12.181 12.9949 11.8119 12.8526 13.4682 10.3097 P26374 RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) CHML REP2 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] VTELCSSTMTCMK 1 2 0.80803 0.011202 0 0 0 4.5345 0 0 0 0 0 0 0 0 P26378 ELAV4_HUMAN ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) ELAVL4 HUD PNEM Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; associative learning [GO:0008306]; cellular response to nerve growth factor stimulus [GO:1990090]; cerebral cortex neuron differentiation [GO:0021895]; dendrite morphogenesis [GO:0048813]; locomotory behavior [GO:0007626]; mRNA processing [GO:0006397]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of dendrite development [GO:1900006]; regeneration [GO:0031099]; regulation of translation at postsynapse [GO:0140245]; response to cocaine [GO:0042220]; response to endoplasmic reticulum stress [GO:0034976]; RNA processing [GO:0006396]; RNA splicing [GO:0008380] apical dendrite [GO:0097440]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158] AINTLNGLR;EIVINESR;ITGQSLGYGFVNYIDPK 3 8.9 0.93772 -0.57558 0 0 0 0 5.41444 0 0 0 0 0 0 0 P26439 3BHS2_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B2 HSDB3B Homo sapiens (Human) androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]" VAWGGDK 1 3.2 0.77804 0.034927 0 0 0 0 0 0 0 11.204 0 0 0 0 P26441 CNTF_HUMAN Ciliary neurotrophic factor (CNTF) CNTF Homo sapiens (Human) astrocyte activation [GO:0048143]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; muscle organ morphogenesis [GO:0048644]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of photoreceptor cell differentiation [GO:0046533]; neuron development [GO:0048666]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of retinal cell programmed cell death [GO:0046668]; retinal rod cell differentiation [GO:0060221]; signal transduction [GO:0007165] axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glial cell projection [GO:0097386]; neuronal cell body [GO:0043025] ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138]; protein-containing complex binding [GO:0044877] DLCSRSIWLARK 1 6 0.84057 -0.046186 0 0 12.3772 0 0 0 0 0 0 0 0 0 P26572 MGAT1_HUMAN "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)" MGAT1 GGNT1 GLCT1 GLYT1 MGAT Homo sapiens (Human) in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine catabolic process [GO:0006049]; viral protein processing [GO:0019082] endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] "acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]" KELGEVR 1 1.6 0.91029 -0.31836 0 0 0 0 0 0 0 0 0 0 8.3072 0 P26599 PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) PTBP1 PTB Homo sapiens (Human) "IRES-dependent viral translational initiation [GO:0075522]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of RNA splicing [GO:0033119]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]" extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] AQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLR;EGQEDQGLTK;GQPIYIQFSNHK;IAIPGLAGAGNSVLLVSNLNPER;LSLDGQNIYNACCTLRIDFSK;MDGIVPDIAVGTK;MDGIVPDIAVGTKR;VTNLLMLK 8 22.8 0 54.491 12.2682 12.9896 12.853 9.658 10.8814 10.1575 12.0913 8.98778 9.24196 11.2731 11.3959 10.7287 P26639 SYTC_HUMAN "Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)" TARS1 TARS Homo sapiens (Human) threonyl-tRNA aminoacylation [GO:0006435] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GFQEVVTPNIFNSR;IRNAQLAQYNFILVVGEKEK;IYGISFPDPK;LNLSTRPEK;NELSGALTGLTR;TISETIER;VNTPTTTVYR;VTLPDGK;WELNSGDGAFYGPK 9 14.4 0.083728 0.39342 10.9149 0 11.5649 0 8.18339 0 10.5448 10.853 0 10.9201 10.8738 0 P26640 SYVC_HUMAN Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) VARS1 G7A VARS VARS2 Homo sapiens (Human) tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] ALIAARYGEAGEGPGWGGAHPR;EVYLHAIVRDAHGR;SSAQDPQAVLGALGR;YQHLKGKNVIHPFLSR 4 5.3 0.23491 0.29473 0 8.40357 9.80502 0 10.5054 0 10.4967 0 0 9.27559 8.7003 0 P26641 EF1G_HUMAN Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G EF1G PRO1608 Homo sapiens (Human) response to virus [GO:0009615]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634] cadherin binding [GO:0045296]; translation elongation factor activity [GO:0003746] AAGTLYTYPENWR;ALIAAQYSGAQVR;AVLGEVK;FAETQPK;ILGLLDAYLK;KLDPGSEETQTLVR;LDPGSEETQTLVR;MAQFDAK;QAFPNTNR;QVLEPSFR;STFVLDEFKR;STFVLDEFKRK;TFLVGER;VTLADITVVCTLLWLYK 14 27.9 0 37.743 12.9897 13.4543 13.845 8.20667 10.6493 9.61067 12.7414 13.0531 13.0243 12.4436 13.4823 11.1107 P26651 TTP_HUMAN mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) ZFP36 G0S24 NUP475 RNF162A TIS11A TTP Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; hematopoietic stem cell differentiation [GO:0060218]; MAPK cascade [GO:0000165]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; mRNA transport [GO:0051028]; myeloid cell differentiation [GO:0030099]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of polynucleotide adenylyltransferase activity [GO:1904246]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; p38MAPK cascade [GO:0038066]; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA [GO:1901835]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; response to starvation [GO:0042594]; response to wounding [GO:0009611]" CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] 14-3-3 protein binding [GO:0071889]; C-C chemokine binding [GO:0019957]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063] RDPTPVCCPSCRR 1 4 0.76985 0.056601 0 0 0 0 3.27697 0 4.72961 0 0 0 0 0 P26842 CD27_HUMAN CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27) CD27 TNFRSF7 Homo sapiens (Human) adaptive immune memory response involving T cells and B cells [GO:0090717]; CD27 signaling pathway [GO:0160162]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway [GO:0097191]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of JNK cascade [GO:0046330]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell differentiation [GO:0045582]; response to ethanol [GO:0045471]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; transmembrane signaling receptor activity [GO:0004888] EEEGSTIPIQEDYRKPEPACSP 1 8.5 0.88328 -0.17325 0 0 0 0 0 0 0 11.1411 0 0 0 0 P26927 HGFL_HUMAN Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] MST1 D3F15S2 DNF15S2 HGFL Homo sapiens (Human) negative regulation of gluconeogenesis [GO:0045721]; proteolysis [GO:0006508]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] receptor tyrosine kinase binding [GO:0030971] GKGEGYR;VDRLDQRR;YACKDLR 3 3.1 0.97506 -4.0117 0 0 10.6807 0 0 0 0 0 10.4418 0 0 8.94281 P26951 IL3RA_HUMAN Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123) IL3RA IL3R Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; interleukin-3-mediated signaling pathway [GO:0038156]; positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-3 receptor activity [GO:0004912] CNKTHSFMHWK;VLLWLTLLLIALPCLLQTK 2 7.9 0.81121 -0.015038 0 0 0 0 0 0 0 5.92258 0 0 0 7.72846 P27037 AVR2A_HUMAN Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) ACVR2A ACVR2 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; gastrulation with mouth forming second [GO:0001702]; mesoderm development [GO:0007498]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; penile erection [GO:0043084]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nitric oxide biosynthetic process [GO:0045428]; Sertoli cell proliferation [GO:0060011]; sperm ejaculation [GO:0042713]; spermatogenesis [GO:0007283] activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein serine/threonine kinase activity [GO:0004674]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" DAFLRIDMYAMGLVLWELASR;KDSPEVYFCCCEGNMCNEK;RHCFATWK 3 9.4 0.89799 -0.23827 0 0 0 9.22272 0 0 6.90328 0 0 0 0 9.40971 P27105 STOM_HUMAN Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) STOM BND7 EPB72 Homo sapiens (Human) positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of viral process [GO:0048524]; regulation of monoatomic ion transmembrane transport [GO:0034765] azurophil granule membrane [GO:0035577]; blood microparticle [GO:0072562]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982] identical protein binding [GO:0042802]; ion channel inhibitor activity [GO:0008200]; protein homodimerization activity [GO:0042803]; RNA polymerase binding [GO:0070063] AKVIAAEGEMNASRALK;AMAAEAEASR;MAEKRHTR;TISFDIPPQEILTK 4 17 0.97108 -1.346 0 0 0 9.39309 10.5015 0 0 0 0 0 0 7.72356 P27144 KAD4_HUMAN "Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)" AK4 AK3 AK3L1 Homo sapiens (Human) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; regulation of oxidative phosphorylation [GO:0002082]; ribonucleoside diphosphate biosynthetic process [GO:0009188] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] (deoxy)adenylate kinase activity [GO:0047506]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; GTP binding [GO:0005525]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; nucleoside triphosphate adenylate kinase activity [GO:0046899] LSRRWIHPPSGR 1 5.4 0.86827 -0.093731 0 0 9.7682 0 0 0 0 0 0 0 0 0 P27216 ANX13_HUMAN Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylglycerol binding [GO:1901611]; phosphatidylserine binding [GO:0001786] LFDRSLESDVK 1 3.5 0.88491 -0.18043 0 0 0 0 0 0 0 10.2508 0 0 0 0 P27338 AOFB_HUMAN Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB Homo sapiens (Human) dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; phenylethylamine catabolic process [GO:0019607]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; substantia nigra development [GO:0021762] dendrite [GO:0030425]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] aliphatic amine oxidase activity [GO:0052595]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; primary methylamine oxidase activity [GO:0008131] DPACHGEDSR;KFVGGSGQVSERIMDLLGDR;LHGGGCR 3 9 0.95504 -0.877 6 10.6767 0 5.69538 0 8.07991 0 5.44969 0 11.0429 0 0 P27348 1433T_HUMAN 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) YWHAQ Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; protein localization [GO:0008104]; protein targeting [GO:0006605]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; synapse [GO:0045202] 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325] AVTEQGAELSNEER;DSTLIMQLLR;EKVESELR;LAEQAER;NLLSVAYK;TELIQKAKLAEQAER;VFYLKMKGDYFR;YDDMATCMK 8 31 0 17.579 0 9.20823 9.18624 0 0 0 0 0 0 11.0465 11.8964 11.5606 P27352 IF_HUMAN Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF) CBLIF GIF IFMH Homo sapiens (Human) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] apical plasma membrane [GO:0016324]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; microvillus [GO:0005902] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419] SGSVLLVVLEEAQR;SLFGQVLK 2 5.3 0.93316 -0.50924 0 0 11.264 10.6349 0 0 0 0 0 0 0 0 P27361 MK03_HUMAN Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) MAPK3 ERK1 PRKM3 Homo sapiens (Human) apoptotic process [GO:0006915]; Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; cardiac neural crest cell development involved in heart development [GO:0061308]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cellular response to amino acid starvation [GO:0034198]; cellular response to mechanical stimulus [GO:0071260]; cellular response to tumor necrosis factor [GO:0071356]; DNA-templated transcription [GO:0006351]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung morphogenesis [GO:0060425]; MAPK cascade [GO:0000165]; modulation of chemical synaptic transmission [GO:0050804]; myelination [GO:0042552]; negative regulation of TORC1 signaling [GO:1904262]; outer ear morphogenesis [GO:0042473]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of cyclase activity [GO:0031281]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; xenophagy [GO:0098792] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ISPFEHQTYCQRTLR;MLTFNPNKR 2 6.3 0.92232 -0.44287 0 0 0 10.9106 0 0 0 0 0 0 0 0 P27448 MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) MARK3 CTAK1 EMK2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to nucleus [GO:1900181]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein binding [GO:0032092]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] FLVLNPIKR;IDIMVGMGYSQEEIQESLSK;LPTEYERNGR 3 5.2 0.88744 -0.18287 0 0 0 7.30223 0 0 0 9.78321 0 0 0 7.3213 P27448 MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) MARK3 CTAK1 EMK2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to nucleus [GO:1900181]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein binding [GO:0032092]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] FLVLNPIKR;IDIMVGMGYSQEEIQESLSK;LTSKLTRSR 3 5.2 0.97826 -1.5105 0 0 0 0 0 0 0 0 0 0 9.05031 0 P27482 CALL3_HUMAN Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1) CALML3 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209] calcium ion binding [GO:0005509] VFDKDGNGFVSAAELR 1 10.7 0.88128 -0.16806 0 0 0 0 7.67037 0 0 0 0 0 0 0 P27487 DPP4_HUMAN Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] DPP4 ADCP2 CD26 Homo sapiens (Human) behavioral fear response [GO:0001662]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; glucagon processing [GO:0120116]; locomotory exploration behavior [GO:0035641]; membrane fusion [GO:0061025]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; peptide hormone processing [GO:0016486]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; psychomotor behavior [GO:0036343]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; symbiont entry into host cell [GO:0046718]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] VLEDNSALDK;VLLGLLGAAALVTIITVPVVLLNK 2 4.4 0.056701 0.46585 0 12.2999 12.1631 0 0 0 0 0 0 0 0 4.15389 P27539 GDF1_HUMAN Embryonic growth/differentiation factor 1 (GDF-1) GDF1 Homo sapiens (Human) negative regulation of cardiac muscle hypertrophy [GO:0010614] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] RDPQETR 1 1.9 0.79651 0.015138 0 0 7.71493 0 0 0 0 0 0 0 0 0 P27540 ARNT_HUMAN "Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)" ARNT BHLHE2 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; embryonic placenta development [GO:0001892]; negative regulation of inflammatory response [GO:0050728]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "aryl hydrocarbon receptor binding [GO:0017162]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" CDDDQMSNDK;CGSSSVDPVSVNR;SFICRMR 3 3.8 0.89737 -0.23806 0 0 0 0 0 0 0 0 5.42811 0 8.0445 0 P27635 RL10_HUMAN Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) RPL10 DXS648E QM Homo sapiens (Human) cytoplasmic translation [GO:0002181]; embryonic brain development [GO:1990403]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of translation [GO:0006417]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] FNADEFEDMVAEK 1 6.1 0 2.0375 0 0 0 0 0 0 0 0 0 8.26838 8.19155 0 P27658 CO8A1_HUMAN Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 C3orf7 Homo sapiens (Human) angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] collagen type VIII trimer [GO:0005591]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] GLPGPQGLRGPKGDK 1 2 0.8575 -0.081203 0 0 0 0 0 9.33269 0 0 0 0 0 0 P27694 RFA1_HUMAN "Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]" RPA1 REPA1 RPA70 Homo sapiens (Human) base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; protein localization to site of double-strand break [GO:1990166]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]" chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; G-rich strand telomeric DNA binding [GO:0098505]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047] ENCMYQACPTQDCNK;NIYLMDTSGK;VIDQQNGLYR;VIDQQNGLYRCEK;VSDFGGR;VTNKSQIR;VVPIASLTPYQSK 7 10.7 0.97352 -2.4705 0 11.7729 11.7972 8.76742 0 6.19032 7.95064 10.7383 0 0 8.73105 10.9777 P27695 APEX1_HUMAN "DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]" APEX1 APE APE1 APEX APX HAP1 REF1 Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell redox homeostasis [GO:0045454]; DNA catabolic process [GO:0006308]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]; telomere maintenance [GO:0000723]; telomere maintenance via base-excision repair [GO:0097698]" "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]" "3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; chromatin DNA binding [GO:0031490]; class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0052720]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(abasic site) binding [GO:0140431]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; double-stranded telomeric DNA binding [GO:0003691]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:0090580]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]" GAVAEDGDELR;NAGFTPQER;QGFGELLQAVPLADSFR 3 11.6 0.0046512 1.3405 0 0 0 0 0 0 0 0 0 0 10.7104 0 P27708 PYR1_HUMAN Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Homo sapiens (Human) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]; xenobiotic metabolic process [GO:0006805] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195] aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; glutaminase activity [GO:0004359]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270] AALVLEDGSVLR;EIEYEVVR;ELSDLESAR;LSLDDLLQRLHHNPR;LYLNETFSELR;MVVMHPMPR;SFPFVSK;SVGEVMGIGRSFEEAFQKALR;VLGTSPEAIDSAENRFK;VLGTSPEAIDSAENRFKFSR;VNEISVEVDSDPRAAYFR;VSRSFPFVSK 12 6 0 8.7528 0 8.88695 11.4038 8.51191 9.57287 11.4663 12.1217 0 12.2258 0 0 10.2205 P27797 CALR_HUMAN Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) CALR CRTC Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; ERAD pathway [GO:0036503]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of meiotic nuclear division [GO:0040020]; response to biphenyl [GO:1904614]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to peptide [GO:1901652]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; postsynapse [GO:0098794]; ribosome [GO:0005840]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; DNA binding [GO:0003677]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; molecular sequestering activity [GO:0140313]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] EDDEDKDEDEEDEEDK;FVLSSGK;FYGDEEK;GLQTSQDAR;IDNSQVESGSLEDDWDFLPPKK;IKDPDASKPEDWDER;QIDNPDYK 7 20.1 0 6.9861 11.6883 11.7291 12.0255 10.1154 8.36763 9.99421 10.4363 9.39133 10.0467 12.1634 12.4349 12.1751 P27815 PDE4A_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)" PDE4A DPDE2 Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to xenobiotic stimulus [GO:0071466]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of cAMP/PKA signal transduction [GO:0141161]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]" IQQRGYSDSAER;QNEVEIPSPTMK 2 2.7 0.97845 -2.1491 0 0 0 0 0 0 0 0 0 0 10.6288 0 P27815 PDE4A_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)" PDE4A DPDE2 Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to xenobiotic stimulus [GO:0071466]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of cAMP/PKA signal transduction [GO:0141161]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]" SQVQARGIDGR 1 3.4 0.88533 -0.18103 7.11374 0 0 0 0 0 0 0 0 0 0 0 P27816 MAP4_HUMAN Microtubule-associated protein 4 (MAP-4) MAP4 Homo sapiens (Human) cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175] axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] ADLSLADALTEPSPDIEGEIKR;DMALATKTEVALAK;DMGPPKENKIVPAK;DMTLPPETNVILTK;EAQTLDSQIQETSI;IESQKLNFKEK;LATNTSAPDLK;NVVLPTETEVAPAK;QPAPTTIGGLNK;TAGPIASAQK;TDYIPLLDVDEK;TEAPLAK;TEVALAK;TQPTSLPK;TSTSKAK;TTTAAAVASTGPSSR;TTTLSGTAPAAGVVPSR;VGSLDNVGHLPAGGAVK 18 19 0 22.862 12.5304 0 11.0387 0 0 0 13.5766 8.2674 10.5853 13.3688 12.6325 11.7342 P27816 MAP4_HUMAN Microtubule-associated protein 4 (MAP-4) MAP4 Homo sapiens (Human) cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175] axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] ELSIEMQDK;ELSIEMQDKDCQEASGHLESR 2 3.9 0.95242 -0.75367 10.8634 0 8.74123 0 0 0 0 0 0 0 0 0 P27816 MAP4_HUMAN Microtubule-associated protein 4 (MAP-4) MAP4 Homo sapiens (Human) cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175] axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] ADLSLADALTEPSPDIEGEIKR;DMALATKTEVALAK;GYMRPTKSRGLTPLLPK;IESQKLNFKEK;LATNTSAPDLK;QPAPTTIGGLNK;TDYIPLLDVDEK;TEVALAK;TQPTSLPK;TSTSKAK;TTTAAAVASTGPSSR;TTTLSGTAPAAGVVPSR;VGSLDNVGHLPAGGAVK 13 20.1 0.48482 0.19005 0 0 0 6.17429 0 0 0 0 0 0 0 0 P27816 MAP4_HUMAN Microtubule-associated protein 4 (MAP-4) MAP4 Homo sapiens (Human) cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175] axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] ADLSLADALTEPSPDIEGEIKR;DMALATKTEVALAK;DMGPPKENKIVPAK;DMTLPPETNVILTK;IESQKLNFKEK;LATNTSAPDLK;LTFRANARAR;NVVLPTETEVAPAK;QPAPTTIGGLNK;TAGPIASAQK;TDYIPLLDVDEK;TEAPLAK;TEVALAK;TQPTSLPK;TSTSKAK;TTTAAAVASTGPSSR;TTTLSGTAPAAGVVPSR;VGSLDNVGHLPAGGAVK 18 18.9 0.76497 0.060638 0 0 0 0 0 0 0 0 0 8.66007 0 0 P27824 CALX_HUMAN Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) CANX Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; synaptic vesicle endocytosis [GO:0048488]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular exosome [GO:0070062]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; nuclear membrane [GO:0031965]; presynapse [GO:0098793] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] ADRRTPTPFAGCR;AEEDEILNR;EIEDPEDR;GDEEEEGEEK;IPDPEAVKPDDWDEDAPAK;IVDDWANDGWGLK;IVDDWANDGWGLKK;QTSGMEYK;SDAEEDGGTVSQEEEDR;TGIYEEK 10 16.7 0 7.1491 12.03 3.94888 11.1374 7.29306 9.15962 9.12869 11.1391 11.0623 12.3027 12.0223 11.8165 12.0268 P27918 PROP_HUMAN Properdin (Complement factor P) CFP PFC Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; positive regulation of immune response [GO:0050778]; positive regulation of opsonization [GO:1903028]" cytoplasmic side of Golgi membrane [GO:0098548]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] NMKSISCQEIPGQQSRGR 1 3.8 0.45792 0.19107 0 0 0 0 6.65148 0 0 0 0 0 0 0 P27930 IL1R2_HUMAN "Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]" IL1R2 IL1RB Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of protein processing [GO:0010955]; protein processing [GO:0016485] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] "interleukin-1 binding [GO:0019966]; interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]" NASYCDKMSIELR 1 3.3 0.92237 -0.44703 0 0 0 0 0 0 0 0 0 0 0 6.223 P27986 P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) PIK3R1 GRB1 Homo sapiens (Human) B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; T follicular helper cell differentiation [GO:0061470]; transcription by RNA polymerase II [GO:0006366] "cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; enzyme-substrate adaptor activity [GO:0140767]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] EGNEKEIQR;LDVKLLYPVSKYQQDQVVK;NESLAQYNPK;TQSSSNLAELR 4 6.8 0.77699 0.042143 0 0 0 0 0 0 0 0 7.64623 0 0 0 P27986 P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) PIK3R1 GRB1 Homo sapiens (Human) B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; T follicular helper cell differentiation [GO:0061470]; transcription by RNA polymerase II [GO:0006366] "cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; enzyme-substrate adaptor activity [GO:0140767]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] EGNEKEIQR;HGDYTLTLR;LDVKLLYPVSKYQQDQVVK;NESLAQYNPK 4 13 0.97214 -1.3583 0 0 0 0 0 0 8.84978 9.03469 11.9641 0 11.3206 0 P27987 IP3KB_HUMAN "Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)" ITPKB Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; common myeloid progenitor cell proliferation [GO:0035726]; inositol phosphate biosynthetic process [GO:0032958]; inositol trisphosphate metabolic process [GO:0032957]; MAPK cascade [GO:0000165]; myeloid cell homeostasis [GO:0002262]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neutrophil apoptotic process [GO:0033030]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of Ras protein signal transduction [GO:0046579]; positive thymic T cell selection [GO:0045059]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634] "ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]" AGLAWTRGTGVQSEGTWESQR 1 2.2 0.91923 -0.43681 10.1232 0 0 0 0 0 0 0 0 0 0 0 P28039 AOAH_HUMAN Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] AOAH Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; lipopolysaccharide catabolic process [GO:0009104]; negative regulation of inflammatory response [GO:0050728] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576] acyloxyacyl hydrolase activity [GO:0050528]; calcium ion binding [GO:0005509] AEQLSNTLKK;FTLQKAR;GYHWRGR;VQLQWPQILGK 4 6.1 0.97488 -3.2675 0 11.4201 0 0 0 0 0 0 0 0 11.8588 0 P28066 PSA5_HUMAN Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) PSMA5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]" EAIKSSLIILKQVMEEK;GVNTFSPEGR 2 11.2 0.012448 0.89076 2.12724 6.1586 12.3224 0 0 0 10.7312 10.8994 10.7237 12.4462 0 0 P28066 PSA5_HUMAN Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) PSMA5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]" EAIKSSLIILKQVMEEK;EPSSIEK 2 13.1 0.9115 -0.32112 0 6.5281 0 0 0 0 0 0 0 0 0 0 P28069 PIT1_HUMAN Pituitary-specific positive transcription factor 1 (PIT-1) (Growth hormone factor 1) (GHF-1) POU1F1 GHF1 PIT1 Homo sapiens (Human) adenohypophysis development [GO:0021984]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lncRNA binding [GO:0106222]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" VGANERK 1 2.4 0.92921 -0.4851 0 0 0 0 0 0 0 0 0 0 0 9.41973 P28070 PSB4_HUMAN Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) (Proteasome subunit beta-7) (beta-7) PSMB4 PROS26 Homo sapiens (Human) negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" lipopolysaccharide binding [GO:0001530] DARSYNRFQIATVTEK;QPVLSQTEAR;VLYYRDAR 3 11.7 0.98024 -1.8164 0 11.3947 0 0 0 0 0 0 0 0 11.3623 0 P28072 PSB6_HUMAN Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1) PSMB6 LMPY Y Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" cadherin binding [GO:0045296]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298] DGSSGGVIR;LAAIAESGVER;QVLLGDQIPK;TTTGSYIANR 4 16.7 0 3.7678 11.8021 9.76476 12.0023 10.1472 0 0 0 0 0 12.2948 11.3228 0 P28074 PSB5_HUMAN Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) PSMB5 LMPX MB1 X Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979] "centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298] IYELRNK 1 2.7 0.90342 -0.26526 0 0 0 0 8.63847 0 0 0 0 0 0 0 P28161 GSTM2_HUMAN Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) GSTM2 GST4 Homo sapiens (Human) cellular detoxification of nitrogen compound [GO:0070458]; cellular response to caffeine [GO:0071313]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; nitrobenzene metabolic process [GO:0018916]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; relaxation of cardiac muscle [GO:0055119]; xenobiotic catabolic process [GO:0042178] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; sarcoplasmic reticulum [GO:0016529] enzyme binding [GO:0019899]; fatty acid binding [GO:0005504]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] FLPRPVFTKMAVWGNK;ISAYMKSSR;ITQSNAILR;LLLEYTDSSYEEKK;SSRFLPRPVFTK 5 22 0.97535 -3.1745 0 0 0 0 9.21958 0 11.6091 0 0 10.0115 0 10.3779 P28288 ABCD3_HUMAN ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) ABCD3 PMP70 PXMP1 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803] FDHVPLATPNGDVLIRDLNFEVR;IANPDQLLTQDVEK;IVLAGREMTR;KVGITLFTVSHR;STHSELLEDYYQSGR 5 11.2 0.97507 -1.4395 0 6.9535 0 0 5.75726 0 10.425 0 0 0 5.90833 0 P28289 TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) TMOD1 D9S57E TMOD Homo sapiens (Human) actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] IDNQSQPLGNK;SYRRELEK 2 5.3 0.92967 -0.46801 0 0 0 0 0 0 0 0 0 10.0451 0 0 P28290 ITPI2_HUMAN Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) ITPRID2 CS1 KIAA1927 KRAP SSFA2 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102] AAAVADKRK;AVRMPSPFR;DEPDIASKIPSRFFNSSSFAK;FEVDQLQGLRNSVRMELQDLELQLEER;ILNVSVIEESGNK;KESSSMLATVK;LMKTLSKLNLCVDK;LNLCVDKTEK;LQFHQKGRSMNSTGSGK;TEKGESSSPSPSAEKGK 10 11 0.97779 -6.0224 12.8319 7.81967 10.9919 11.3432 0 11.8528 0 0 0 0 0 0 P28324 ELK4_HUMAN ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) ELK4 SAP1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LLQAEEVARLWGIRK 1 3.5 0.50296 0.18866 0 8.95542 0 0 0 0 0 0 0 0 0 0 P28328 PEX2_HUMAN Peroxisome biogenesis factor 2 (EC 2.3.2.27) (EC 2.3.2.36) (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72) PEX2 PAF1 PMP3 PMP35 PXMP3 RNF72 Homo sapiens (Human) "cellular response to reactive oxygen species [GO:0034614]; fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; peroxisome organization [GO:0007031]; pexophagy [GO:0000425]; protein destabilization [GO:0031648]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein monoubiquitination [GO:0006513]; response to amino acid starvation [GO:1990928]; very long-chain fatty acid metabolic process [GO:0000038]" Cdc73/Paf1 complex [GO:0016593]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778] protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ASRKENAK;LGGLINFLIFLQR;LGGLINFLIFLQRGK;SGIEMSEVNAL 4 11.1 0.96533 -1.2473 0 0 2.69432 11.0688 0 4.41278 0 5.25096 7.88429 0 0 0 P28329 CLAT_HUMAN Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) CHAT Homo sapiens (Human) acetylcholine biosynthetic process [GO:0008292]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; phosphatidylcholine biosynthetic process [GO:0006656] cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202] choline O-acetyltransferase activity [GO:0004102] FQEGRVDNIR;GLGGGGK;GQLSGQPLCMK;TPSSEESGLPK 4 5.2 0.97877 -2.0589 8.3102 0 0 7.97923 7.74725 8.41853 8.26889 0 0 7.25597 7.8009 0 P28331 NDUS1_HUMAN "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD)" NDUFS1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] "2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" ASQTMAK;INMLRIPVR;NIGPLVK;TIMTRCIQCTRCIR 4 5 0.98092 -2.0263 0 8.00669 0 8.48547 11.5515 0 0 0 0 0 0 0 P28332 ADH6_HUMAN Alcohol dehydrogenase 6 (EC 1.1.1.1) ADH6 Homo sapiens (Human) retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; extracellular exosome [GO:0070062] alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; zinc ion binding [GO:0008270] TQLMSDGTSR 1 2.7 0.89748 -0.23585 7.18735 0 0 0 0 0 0 0 0 0 0 0 P28335 5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) HTR2C HTR1C Homo sapiens (Human) "behavioral fear response [GO:0001662]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; intracellular calcium ion homeostasis [GO:0006874]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; regulation of appetite [GO:0032098]; regulation of corticotropin-releasing hormone secretion [GO:0043397]; regulation of nervous system process [GO:0031644]; release of sequestered calcium ion into cytosol [GO:0051209]; serotonin receptor signaling pathway [GO:0007210]" dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; synapse [GO:0045202] "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589]" AIMKIAIVWAISIGVSVPIPVIGLR;IAIVWAISIGVSVPIPVIGLR;NPIEHSR 3 7 0.90158 -0.2624 4.26123 0 0 0 0 8.26313 9.0913 0 0 0 5.08687 11.6638 P28340 DPOD1_HUMAN DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) POLD1 POLD Homo sapiens (Human) "base-excision repair, gap-filling [GO:0006287]; cellular response to UV [GO:0034644]; DNA biosynthetic process [GO:0071897]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; fatty acid homeostasis [GO:0055089]; nucleotide-excision repair, DNA gap filling [GO:0006297]; response to UV [GO:0009411]" aggresome [GO:0016235]; cytosol [GO:0005829]; delta DNA polymerase complex [GO:0043625]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634] "3'-5'-DNA exonuclease activity [GO:0008296]; 4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" DSSFQSK;EVSHLNALEER;GDHTRCK;ITVALPR;ITVALPRLVAPARR 5 3.5 0.97556 -2.3497 0 0 9.36374 0 5.85609 4.07502 0 0 10.4535 0 7.97355 8.54199 P28347 TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) TEAD1 TCF13 TEF1 Homo sapiens (Human) embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NELIARYIK;SIGTTKLR;VTSMDQTAKDK 3 7.8 0.97464 -3.0945 0 0 0 0 0 0 0 0 0 0 0 10.3925 P28358 HXD10_HUMAN Homeobox protein Hox-D10 (Homeobox protein Hox-4D) (Homeobox protein Hox-4E) HOXD10 HOX4D HOX4E Homo sapiens (Human) adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; negative regulation of cell cycle [GO:0045786]; neuromuscular process [GO:0050905]; peripheral nervous system neuron development [GO:0048935]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]; spinal cord motor neuron cell fate specification [GO:0021520] chromatin [GO:0000785]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EESNCCMYSDK;VSQVESPEAK 2 6.2 0.93536 -0.52939 0 0 0 0 0 0 0 0 2.83883 5.39355 0 0 P28360 MSX1_HUMAN Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) MSX1 HOX7 Homo sapiens (Human) "activation of meiosis [GO:0090427]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; bone morphogenesis [GO:0060349]; cardiac conduction system development [GO:0003161]; cartilage morphogenesis [GO:0060536]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway involved in heart development [GO:0061311]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic morphogenesis [GO:0048598]; embryonic nail plate morphogenesis [GO:0035880]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; mammary gland epithelium development [GO:0061180]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of odontoblast differentiation [GO:1901330]; negative regulation of striated muscle cell differentiation [GO:0051154]; nose development [GO:0043584]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of odontogenesis [GO:0042482]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of odontogenesis [GO:0042481]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]" chromatin [GO:0000785]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; p53 binding [GO:0002039]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" FSPPPAR 1 2.3 0.91153 -0.32775 0 0 7.41049 0 0 0 0 0 0 0 0 4.34035 P28370 SMCA1_HUMAN Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) SMARCA1 SNF2L SNF2L1 Homo sapiens (Human) brain development [GO:0007420]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] ATPase complex [GO:1904949]; CERF complex [GO:0090537]; chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleosome array spacer activity [GO:0140750]; nucleosome binding [GO:0031491]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] ANEKYGRDDIDNIAR;EILYYRK;LHAVLKPFLLRRIK;MGESSLRNFRMDIEQSLYK;TPMVKFSAFS 5 6.2 0.9631 -1.091 0 9.13124 0 9.66826 0 3.07401 4.40552 10.2734 0 2.06712 0 8.06356 P28472 GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) GABRB3 Homo sapiens (Human) "cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594] NDRSKSESNR;NRMIRLHPDGTVLYGLR 2 5.7 0.9767 -2.2757 0 0 0 0 0 10.598 0 0 0 0 0 0 P28476 GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABAAR subunit rho-2) (GABA(C) receptor) GABRR2 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; visual perception [GO:0007601] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; intracellular vesicle [GO:0097708]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IWVPDVFFVHSK;NGDESLKTDEK 2 4.9 0.98087 -1.711 0 0 0 0 0 8.31692 11.3887 0 11.4798 8.6427 0 0 P28482 MK01_HUMAN Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) MAPK1 ERK2 PRKM1 PRKM2 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; Bergmann glial cell differentiation [GO:0060020]; cardiac neural crest cell development involved in heart development [GO:0061308]; caveolin-mediated endocytosis [GO:0072584]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amino acid starvation [GO:0034198]; cellular response to tumor necrosis factor [GO:0071356]; chemical synaptic transmission [GO:0007268]; chemotaxis [GO:0006935]; cytosine metabolic process [GO:0019858]; DNA damage response [GO:0006974]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; learning or memory [GO:0007611]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; mammary gland epithelial cell proliferation [GO:0033598]; myelination [GO:0042552]; negative regulation of cell differentiation [GO:0045596]; outer ear morphogenesis [GO:0042473]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of telomere maintenance [GO:0032206]; progesterone receptor signaling pathway [GO:0050847]; protein phosphorylation [GO:0006468]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of protein stability [GO:0031647]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; response to nicotine [GO:0035094]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; steroid hormone receptor signaling pathway [GO:0043401]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440] azurophil granule lumen [GO:0035578]; caveola [GO:0005901]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; synapse [GO:0045202] ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] AAAAAAGAGPEMVR;ISPFEHQTYCQRTLR 2 8.1 0 3.7982 7.49785 0 13.3614 0 0 0 10.0815 8.71774 0 10.4365 0 0 P28562 DUS1_HUMAN Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) DUSP1 CL100 MKP1 PTPN10 VH1 Homo sapiens (Human) cellular response to chemokine [GO:1990869]; endoderm formation [GO:0001706]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of p38MAPK cascade [GO:1903753]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase binding [GO:0051019]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" LDEAFEFVK;LDEAFEFVKQRR 2 3.3 0.9804 -1.7198 0 0 11.6289 0 0 0 9.70044 0 0 0 0 0 P28566 5HT1E_HUMAN 5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E) HTR1E Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] ILGLILGAFILSWLPFFIK 1 5.2 0.64796 0.17037 0 0 0 0 0 8.19461 0 0 7.09413 0 0 7.42097 P28698 MZF1_HUMAN Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) MZF1 MZF ZNF42 ZSCAN6 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" SEQDPTDEDPCR 1 1.6 0.80822 0.010996 7.83744 8.32224 0 5.78228 0 0 0 0 0 0 0 0 P28715 ERCC5_HUMAN DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) ERCC5 ERCM2 XPG XPGC Homo sapiens (Human) "base-excision repair, AP site formation [GO:0006285]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II complex binding [GO:0000993]; single-stranded DNA binding [GO:0003697] HSSEEEDEK;HSSEEEDEKEWQER;INSSTENSDEGLKVRDGK;LLECSGRQVSPEALEGK;TAFRSKR;TSASDSQNSVKEAPVK 6 6.1 0.97537 -3.3966 10.3766 8.55857 0 9.18043 0 9.79516 0 0 8.64144 7.48752 5.84479 0 P28749 RBL1_HUMAN Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) RBL1 Homo sapiens (Human) cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of cellular senescence [GO:2000773]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid kinase activity [GO:0043550] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] ISQQHSIYISPHK;LDVSNELRR;LSLIQFFSKMK;LTAQANVEYNLQQHFEKK;RVIAIDSDAESPAK;YEPIFLDIFQNPYEEPPK;YLREKEAVITPVASATQSVSR 7 9.7 0.40488 0.2075 0 10.8659 0 10.7279 0 9.42436 10.32 11.7235 0 0 10.0041 0 P28799 GRN_HUMAN Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) astrocyte activation involved in immune response [GO:0002265]; lysosomal lumen acidification [GO:0007042]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; microglial cell activation involved in immune response [GO:0002282]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; positive regulation of angiogenesis [GO:0045766]; positive regulation of aspartic-type peptidase activity [GO:1905247]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of lysosome organization [GO:1905673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein folding [GO:1903334]; protein stabilization [GO:0050821]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723] CDMEVSCPDGYTCCR;DVECGEGHFCHDNQTCCR;DVECGEGHFCHDNQTCCRDNR 3 6.1 0.68598 0.16335 0 0 0 0 0 0 6.66562 6.62442 3.27694 0 0 0 P28827 PTPRM_HUMAN Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IAGVIAGILLFVIIFLGVVLVMKK;SLYYDMNK;TVDVFHAVK 3 2.8 0.95479 -0.79881 0 0 0 3.64085 0 0 11.4036 11.9046 12.4469 0 0 0 P28838 AMPL_HUMAN Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 LAPEP PEPS Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233] FAEIIEK;FLLPLPAAGRVVVR;WAHLDIAGVMTNKDEVPYLR 3 7.9 0.95292 -0.77392 0 0 0 0 0 5.18349 0 8.58218 0 8.68163 0 0 P28906 CD34_HUMAN Hematopoietic progenitor cell antigen CD34 (CD antigen CD34) CD34 Homo sapiens (Human) cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; endothelium development [GO:0003158]; extracellular exosome assembly [GO:0071971]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; mesangial cell-matrix adhesion [GO:0035759]; metanephric glomerular mesangial cell differentiation [GO:0072254]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-2 production [GO:0032703]; paracrine signaling [GO:0038001]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of odontogenesis [GO:0042482]; positive regulation of vasculogenesis [GO:2001214]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; transdifferentiation [GO:0060290]; vascular wound healing [GO:0061042] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glomerular endothelium fenestra [GO:0036053]; intercellular bridge [GO:0045171]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sulfate binding [GO:0043199] LTQGICLEQNK;LVRRGAR 2 4.7 0.93797 -0.57438 0 0 0 0 0 0 0 0 0 0 7.14558 0 P28907 CD38_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38) CD38 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; artery smooth muscle contraction [GO:0014824]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; female pregnancy [GO:0007565]; long-term synaptic depression [GO:0060292]; NAD metabolic process [GO:0019674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vasoconstriction [GO:0045907]; response to estradiol [GO:0032355]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]" NIYRPDK;NSTFGSVEVHNLQPEK;RAQLCLGVSILVLILVVVLAVVVPR 3 16 0.91335 -0.38561 0 0 0 0 4.25754 0 0 0 0 8.85814 0 0 P28908 TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) TNFRSF8 CD30 D1S166E Homo sapiens (Human) cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] protease binding [GO:0002020]; transmembrane signaling receptor activity [GO:0004888] LELVDSRPR;VLLAALGLLFLGALR 2 4 0.87805 -0.13624 0 0 0 0 9.14512 0 4.20508 0 0 0 0 0 P29016 CD1B_HUMAN T-cell surface glycoprotein CD1b (CD antigen CD1b) CD1B Homo sapiens (Human) "adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" cell surface [GO:0009986]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] AQKFCALIIQYQGIMETVR 1 5.7 0.91556 -0.43101 0 0 0 5.30761 0 0 0 0 0 0 0 0 P29033 CXB2_HUMAN Gap junction beta-2 protein (Connexin-26) (Cx26) GJB2 Homo sapiens (Human) cell-cell signaling [GO:0007267]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oxidative stress [GO:0034599]; decidualization [GO:0046697]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; response to estradiol [GO:0032355]; response to human chorionic gonadotropin [GO:0044752]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; sensory perception of sound [GO:0007605]; transmembrane transport [GO:0055085] astrocyte projection [GO:0097449]; cell body [GO:0044297]; connexin complex [GO:0005922]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; gap junction [GO:0005921]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; identical protein binding [GO:0042802] HSTSIGKIWLTVLFIFRIMILVVAAK 1 11.5 0.68343 0.16504 0 0 0 0 6.851 0 0 0 0 0 0 0 P29034 S10A2_HUMAN Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2) S100A2 S100L Homo sapiens (Human) endothelial cell migration [GO:0043542] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914] VDEEGLK 1 7.1 0.5709 0.18211 0 0 0 0 0 0 0 0 8.63125 0 0 0 P29074 PTN4_HUMAN Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1) PTPN4 Homo sapiens (Human) protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "cytoskeletal protein binding [GO:0008092]; glutamate receptor binding [GO:0035254]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" FVCEAILK 1 0.9 0.91327 -0.39033 0 11.459 0 0 0 0 0 0 0 0 0 0 P29083 T2EA_HUMAN General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) GTF2E1 TF2E1 Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673] metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251] RRIETDER;VETAADGKTTR 2 4.3 0.974 -2.9899 0 0 10.8963 0 10.4616 0 0 0 0 0 0 0 P29084 T2EB_HUMAN Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) GTF2E2 TF2E2 Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673] DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251] IVNYMKTR;KVAPIQR;VAPIQRR 3 5.5 0.95956 -1.0452 11.5378 11.6534 11.9428 0 0 0 9.66571 10.3785 0 0 0 0 P29120 NEC1_HUMAN Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) PCSK1 NEC1 Homo sapiens (Human) cell-cell signaling [GO:0007267]; insulin processing [GO:0030070]; neurogenesis [GO:0022008]; pancreas development [GO:0031016]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; pituitary gland development [GO:0021983]; positive regulation of protein secretion [GO:0050714]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to chlorate [GO:0010157]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410] axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] AFEYGVKQGRQGK;ECVVKDNDFEPRALK;IVNWKLILHGTSSQPEHMK;KNGAGLMVNSR 4 7.7 0.97915 -1.535 0 0 7.11873 5.90282 8.16385 9.04204 0 7.18329 0 7.59283 0 0 P29122 PCSK6_HUMAN Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) PCSK6 PACE4 Homo sapiens (Human) "determination of left/right symmetry [GO:0007368]; glycoprotein metabolic process [GO:0009100]; nerve growth factor production [GO:0032902]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; regulation of BMP signaling pathway [GO:0030510]; secretion by cell [GO:0032940]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; serine-type endopeptidase activity [GO:0004252] MWYLHCGDKNSR;TVDGPGR 2 3.8 0.90657 -0.27386 0 6.68159 0 8.10774 0 0 0 0 0 0 0 0 P29144 TPP2_HUMAN Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) TPP2 Homo sapiens (Human) intracellular amino acid homeostasis [GO:0080144]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240] ACIDSNEDGDLSKSTVLR;ALENTAVK;DLPFIVSHR;FATKLVEEKPTKENWK;IQWMTKLDSSDIYNELK;LGFTVTVGNNR;QLYEMVLTYNFHQPK;VALAEACRK 8 8.2 0.97677 -5.4562 0 11.5577 0 10.263 8.63938 0 0 0 0 0 0 0 P29279 CCN2_HUMAN CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) CCN2 CTGF HCS24 IGFBP8 Homo sapiens (Human) angiogenesis [GO:0001525]; cartilage condensation [GO:0001502]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; DNA biosynthetic process [GO:0071897]; epidermis development [GO:0008544]; fibroblast growth factor receptor signaling pathway [GO:0008543]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; ossification [GO:0001503]; positive regulation of cell differentiation [GO:0045597]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of stress fiber assembly [GO:0051496]; reactive oxygen species metabolic process [GO:0072593]; regulation of chondrocyte differentiation [GO:0032330]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178] CCEEWVCDEPK 1 3.2 0.71152 0.15543 0 0 0 0 3.48556 6.15119 0 0 6.11749 0 0 0 P29317 EPHA2_HUMAN Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) EPHA2 ECK Homo sapiens (Human) activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cAMP metabolic process [GO:0046058]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of lymphangiogenesis [GO:1901491]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; tight junction [GO:0070160] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; molecular function activator activity [GO:0140677]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] EVPVAIK;VVQMTNDDIK 2 1.7 0.90974 -0.31154 0 0 0 0 0 0 7.33896 0 0 11.1014 11.9921 0 P29320 EPHA3_HUMAN Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) EPHA3 ETK ETK1 HEK TYRO4 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; negative regulation of endocytosis [GO:0045806]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ALDGNMK;CGWNIKQCEPCSPNVR;DVTFNIICKKCGWNIK;QCEPCSPNVR 4 3.4 0.96532 -1.1235 0 0 4.46009 7.33074 0 0 0 0 0 8.22279 0 0 P29322 EPHA8_HUMAN Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) EPHA8 EEK HEK3 KIAA1459 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; ephrin receptor signaling pathway [GO:0048013]; neuron projection development [GO:0031175]; neuron remodeling [GO:0016322]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; substrate-dependent cell migration [GO:0006929] dendrite [GO:0030425]; early endosome membrane [GO:0031901]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AFQDSDEEK;GVGAGMR 2 1.6 0.89785 -0.23263 8.6879 8.43655 0 0 0 0 0 0 0 9.61721 0 8.99124 P29323 EPHB2_HUMAN Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; hindbrain tangential cell migration [GO:0021934]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; learning or memory [GO:0007611]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; postsynaptic membrane assembly [GO:0097104]; regulation of autophagosome assembly [GO:2000785]; regulation of behavioral fear response [GO:2000822]; regulation of blood coagulation [GO:0030193]; regulation of body fluid levels [GO:0050878]; regulation of filopodium assembly [GO:0051489]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T-helper 17 type immune response [GO:2000316]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; urogenital system development [GO:0001655]; vesicle-mediated intercellular transport [GO:0110077] axon [GO:0030424]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DVTKKTCNSNDGK;EFAKEIDISCVK;EFAKEIDISCVKIEQVIGAGEFGEVCSGHLK;ESNDCSCGG;IPIRWTAPEAIQYRK;LPLIIGSSAAGLVFLIAVVVIAIVCNRR;SCGSGRGACTRCGDNVQYAPR;TVAGYGR 8 11.8 0.97585 -2.3334 4.13332 11.0778 0 11.4742 8.25006 0 0 0 12.5967 7.25465 0 0 P29350 PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) PTPN6 HCP PTP1C Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; CD27 signaling pathway [GO:0160162]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; epididymis development [GO:1905867]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; MAPK cascade [GO:0000165]; megakaryocyte development [GO:0035855]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein dephosphorylation [GO:0006470]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" MVRWFHR;NQGDFSLSVRVGDQVTHIR 2 4.4 0.97075 -1.3411 0 0 0 0 0 0 0 0 0 0 3.59323 0 P29350 PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) PTPN6 HCP PTP1C Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; CD27 signaling pathway [GO:0160162]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; epididymis development [GO:1905867]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; MAPK cascade [GO:0000165]; megakaryocyte development [GO:0035855]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein dephosphorylation [GO:0006470]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" MLSRGWFHR;NQGDFSLSVRVGDQVTHIR 2 4.7 0.90153 -0.26387 0 0 4.69644 0 0 0 9.57306 0 0 0 0 0 P29353 SHC1_HUMAN SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) SHC1 SHC SHCA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; regulation of superoxide metabolic process [GO:0090322] cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435] ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] EAISLVCEAVPGAKGATRR;GEPWFHGK 2 4.6 0.94165 -0.61265 0 0 0 6.74187 0 0 0 0 0 0 0 0 P29371 NK3R_HUMAN Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) positive regulation of blood pressure [GO:0045777]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of heart rate [GO:0010460]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; tachykinin receptor signaling pathway [GO:0007217] dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] tachykinin receptor activity [GO:0004995] MESMTVVFDPNDADTTR;TTRFHPNR 2 5.4 0.97961 -1.5452 0 0 4.96176 0 0 10.1147 0 0 0 0 0 0 P29372 3MG_HUMAN DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) MPG AAG ANPG MID1 Homo sapiens (Human) base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA alkylation repair [GO:0006307] cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-5-methylcytosine glycosylase activity [GO:1990053]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916] SGAQFCRRMGQK 1 4.1 0.76877 0.056858 0 0 0 0 0 0 0 0 9.09922 0 0 0 P29374 ARI4A_HUMAN AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) ARID4A RBBP1 RBP1 Homo sapiens (Human) erythrocyte development [GO:0048821]; establishment of Sertoli cell barrier [GO:0097368]; genomic imprinting [GO:0071514]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976] CDSEGEEDEEDMEPCLTGTK;EDSEKDEK;EEESSEEEDEDK;ISFLQEKLQEIRK;ISPHIKDGEKDK;LQEIRKYYMSLK;LVKVKVLLK;RTSAAAK;TVHHHEPKVKEEK;TVKRLVK 10 8.3 0.97362 -2.5529 0 10.7274 10.0723 5.25263 9.85692 0 8.6664 5.40398 10.2029 5.00491 7.99152 0 P29375 KDM5A_HUMAN Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) KDM5A JARID1A RBBP2 RBP2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] AREWTAK;DKEDEVTRR;GSSWQAKEVKFLCPLCMR;KVLDIPSK;LGYLPGK;LSVLSQRMVEQAAREK;RPRLETILSLLVSLQK;TEKIISAELQK;VVGLAMGTKDKEDEVTR 9 6 0.97476 -3.1968 7.37868 9.87606 7.77972 4.5157 0 6.08245 11.91 7.49609 0 13.5382 6.80155 12.0808 P29401 TKT_HUMAN Transketolase (TK) (EC 2.2.1.1) TKT Homo sapiens (Human) "glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; xylulose 5-phosphate biosynthetic process [GO:1901159]" cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] AVELAANTK;AYGQALAK;DAIAQAVR;HQPTAIIAK;IIALDGDTK;ILATPPQEDAPSVDIANIR;ISSDLDGHPVPK;KLILDSAR;LGQSDPAPLQHQMDIYQK;LILDSAR;LQALKDTANR;MESYHKPDQQK;MPSLPSYK;SGKPAELLK;SVPTSTVFYPSDGVATEK;TSRPENAIIYNNNEDFQVGQAK;VLDPFTIKPLDR 17 30.5 0 86.36 12.4683 11.862 0 11.9931 10.7588 10.1992 14.7368 14.7604 15.3106 13.9475 14.7944 11.8015 P29459 IL12A_HUMAN Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1) IL12A NKSF1 Homo sapiens (Human) cell migration [GO:0016477]; cellular response to virus [GO:0098586]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; response to lipopolysaccharide [GO:0032496]; response to UV-B [GO:0010224]; response to virus [GO:0009615] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; late endosome lumen [GO:0031906] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-12 beta subunit binding [GO:0042163]; interleukin-12 receptor binding [GO:0005143]; interleukin-27 binding [GO:0045513]; protein heterodimerization activity [GO:0046982] DKTSTVEACLPLELTK;KTSFMMALCLSSIYEDLK 2 15.5 0.91572 -0.39707 0 0 0 0 10.4564 0 11.3276 0 0 0 0 0 P29460 IL12B_HUMAN Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2) IL12B NKSF2 Homo sapiens (Human) cell migration [GO:0016477]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; interleukin-12-mediated signaling pathway [GO:0035722]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; response to UV-B [GO:0010224]; sexual reproduction [GO:0019953]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]; T-helper cell differentiation [GO:0042093] cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; interleukin-23 complex [GO:0070743]; late endosome lumen [GO:0031906]; receptor complex [GO:0043235] cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; interleukin-12 alpha subunit binding [GO:0042164]; interleukin-12 receptor binding [GO:0005143]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877] NKTFLRCEAK 1 3 0.86373 -0.084469 0 0 0 0 0 0 0 0 11.683 0 0 0 P29474 NOS3_HUMAN "Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)" NOS3 Homo sapiens (Human) angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; calcium ion transport [GO:0006816]; cell redox homeostasis [GO:0045454]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; establishment of localization in cell [GO:0051649]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of Notch signaling pathway [GO:0045747]; potassium ion transport [GO:0006813]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of nervous system process [GO:0031644]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin monomer binding [GO:0003785]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; tetrahydrobiopterin binding [GO:0034617] QAWRNAPR;SVENLQSSK;TTSSLWKDK;VLTAFSREPDNPK 4 3.2 0.97523 -4.2025 0 0 6.2474 0 0 0 0 0 10.5807 0 11.448 0 P29475 NOS1_HUMAN "Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)" NOS1 Homo sapiens (Human) arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to growth factor stimulus [GO:0071363]; multicellular organismal response to stress [GO:0033555]; myoblast fusion [GO:0007520]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of sodium ion transport [GO:0002028]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; striated muscle contraction [GO:0006941]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; synapse [GO:0045202] arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calcium channel regulator activity [GO:0005246]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; tetrahydrobiopterin binding [GO:0034617]; transmembrane transporter binding [GO:0044325] DYCDNSR 1 0.5 0.91093 -0.32682 0 0 0 0 0 7.28512 0 0 0 0 0 0 P29536 LMOD1_HUMAN "Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen)" LMOD1 Homo sapiens (Human) actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838] actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] AGGNTDMK;ENTTLLKLGYHFELAGPRMTVTNLLSR;LLKENTTLLKLGYHFELAGPR;TEMEIAK 4 7.5 0.94239 -0.62154 0 0 8.11795 0 0 4.69966 0 8.95757 6.19582 0 5.36029 0 P29590 PML_HUMAN Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) "apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270] AEGVSTPLAGR;NQSVREFLDGTRK;QEEPQSLQAAVR 3 4.1 0.97904 -1.9614 0 0 0 0 0 0 0 0 0 0 11.1297 0 P29597 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) TYK2 Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; intracellular signal transduction [GO:0035556]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; protein phosphorylation [GO:0006468]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; type 1 angiotensin receptor binding [GO:0031702] SFRRHIR;SLQLVMEYVPLGSLRDYLPR;VEGSGDPEEGK;VSLYCYDPTNDGTGEMVAVK 4 4.9 0.955 -0.96425 2.29525 0 0 0 0 0 0 0 7.16138 0 7.14771 10.9685 P29622 KAIN_HUMAN Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4) SERPINA4 KST PI4 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] serine-type endopeptidase inhibitor activity [GO:0004867] FSISGSYVLDQILPR;LEASKSFHK;LGFTDLFSK;VVDPTKP;YLPCSVLR 5 11.2 0.97863 -2.0595 5.2267 11.0462 0 0 0 0 5.55139 4.14315 0 0 0 11.1808 P29692 EF1D_HUMAN Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) EEF1D EF1D Homo sapiens (Human) cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic translational elongation [GO:0002182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; guanyl-nucleotide exchange factor activity [GO:0005085]; heat shock protein binding [GO:0031072]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]" ATAPQTQHVSPMR;ATNFLAHEK;GVVQELQQAISK;GVVQELQQAISKLEAR;IASLEVENQSLR;LVPVGYGIR;QENGASVILR;QVEPPAK;SIQLDGLVWGASK;SLAGSSGPGASSGTSGDHGELVVR 10 40.2 0.0048193 1.5648 0 0 0 0 0 0 0 0 0 0 11.2155 0 P29692 EF1D_HUMAN Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) EEF1D EF1D Homo sapiens (Human) cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic translational elongation [GO:0002182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; guanyl-nucleotide exchange factor activity [GO:0005085]; heat shock protein binding [GO:0031072]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]" ATAPQTQHVSPMR;GRNILGNK;GVVQELQQAISK;GVVQELQQAISKLEAR;IASLEVENQSLR;LVPVGYGIR;QENGASVILR;QVEPPAK;SIQLDGLVWGASK;SLAGSSGPGASSGTSGDHGELVVR;VWLDKSLFDQAESSYR 11 19.8 0 9.5224 13.8598 12.5226 13.1663 0 7.3572 7.41709 11.4359 11.6968 11.5704 13.0858 12.3986 0 P29728 OAS2_HUMAN 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) OAS2 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of lactation [GO:1903487]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] LKDLIRLVK;SLDGFTIQVFTK 2 2.9 0.95245 -0.73926 0 2.33125 0 0 0 0 0 0 0 0 0 10.6457 P29762 RABP1_HUMAN Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I) CRABP1 RBP5 Homo sapiens (Human) fatty acid transport [GO:0015908]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841] ALGVNAMLR 1 6.6 0.89314 -0.218 0 0 0 14.6053 0 0 16.8782 0 0 0 0 16.0861 P29965 CD40L_HUMAN "CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]" CD40LG CD40L TNFSF5 TRAP Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; CD40 signaling pathway [GO:0023035]; cell surface receptor signaling pathway [GO:0007166]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; isotype switching [GO:0045190]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of apoptotic process [GO:0043066]; platelet activation [GO:0030168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell proliferation [GO:0042102]; regulation of immunoglobulin production [GO:0002637]; T cell costimulation [GO:0031295] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] CD40 receptor binding [GO:0005174]; cytokine activity [GO:0005125]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; tumor necrosis factor receptor binding [GO:0005164] TTSVLQWAEK 1 3.8 0.80532 0.013966 0 0 0 0 0 7.09772 0 0 0 0 0 0 P29966 MARCS_HUMAN "Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)" MARCKS MACS PRKCSL Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mitochondrion organization [GO:0007005]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; response to endoplasmic reticulum stress [GO:0034976] actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; germinal vesicle [GO:0042585]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080] EELQANGSAPAADK;GEPAAAAAPEAGASPVEK;LSGFSFK 3 11.7 0.91663 -0.41408 5.08708 8.59626 10.3228 0 0 0 6.58619 0 0 6.57127 0 0 P29973 CNGA1_HUMAN "Cyclic nucleotide-gated channel alpha-1 (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1)" CNGA1 CNCG CNCG1 Homo sapiens (Human) calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; sodium ion transport [GO:0006814]; visual perception [GO:0007601] intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] AGNRRTANIK;VIKWFDYLWTNKK 2 3.4 0.83286 -0.027776 0 0 6.95268 9.29299 0 9.76704 0 11.087 0 0 0 0 P29992 GNA11_HUMAN Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha) GNA11 GA11 Homo sapiens (Human) "action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to pH [GO:0071467]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; entrainment of circadian clock [GO:0009649]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; heart development [GO:0007507]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; phototransduction, visible light [GO:0007603]; positive regulation of insulin secretion [GO:0032024]; regulation of blood pressure [GO:0008217]; regulation of melanocyte differentiation [GO:0045634]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202] enzyme regulator activity [GO:0030234]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] FVFAAVK;IIHGAGYSEEDKRGFTK;TLWEDPGIQECYDRR 3 10.9 0.92083 -0.44391 0 0 9.82428 0 0 0 4.81522 0 0 5.1382 0 0 P30039 PBLD_HUMAN Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) (MAWD-binding protein) (MAWDBP) (Unknown protein 32 from 2D-page of liver tissue) PBLD MAWBP Homo sapiens (Human) biosynthetic process [GO:0009058]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802]; isomerase activity [GO:0016853] KLHPTDNFAQSSCFGLR 1 5.9 0.56334 0.18262 0 0 0 0 0 0 0 0 0 10.4384 0 0 P30040 ERP29_HUMAN Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) ERP29 C12orf8 ERP28 Homo sapiens (Human) intracellular protein transport [GO:0006886]; negative regulation of gene expression [GO:0010629]; negative regulation of protein secretion [GO:0050709]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein phosphorylation [GO:0001934]; protein folding [GO:0006457]; protein secretion [GO:0009306]; protein unfolding [GO:0043335]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]; transport vesicle [GO:0030133] protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] DGDFENPVPYTGAVK;GALPLDTVTFYK;LNMELSEK;NKMSDGKK;QGQDNLSSVK;SLNILTAFQK;WAEQYLK 7 26.8 0.0089087 1.1389 0 0 0 9.23819 9.58618 9.25328 10.5742 10.8605 9.63494 0 11.776 0 P30041 PRDX6_HUMAN Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12) PRDX6 AOP2 KIAA0106 Homo sapiens (Human) "cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glycerophospholipid catabolic process [GO:0046475]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; response to oxidative stress [GO:0006979]" azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; cadherin binding [GO:0045296]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625] KLFPKGVFTK;LAPEFAK;LSILYPATTGR;PGGLLLGDVAPNFEANTTVGR;VATPVDWK;VVFVFGPDK;VVFVFGPDKKLK 7 30.8 0.017176 0.70118 13.0063 0 12.7475 0 0 9.23587 11.8016 12.479 10.7886 11.2122 11.3075 10.1054 P30043 BLVRB_HUMAN Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) BLVRB FLR SCAN Homo sapiens (Human) heme catabolic process [GO:0042167]; megakaryocyte differentiation [GO:0030219]; negative regulation of insulin receptor signaling pathway [GO:0046627] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] biliverdin reductase [NAD(P)+] activity [GO:0004074]; FMN reductase (NAD(P)H) activity [GO:0008752]; FMN reductase (NADH) activity [GO:0052874]; FMN reductase (NADPH) activity [GO:0052873]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; riboflavin reductase (NADPH) activity [GO:0042602] LQAVTDDHIR 1 4.9 0.81432 -0.0051711 0 0 0 0 0 0 0 0 10.7229 0 0 0 P30044 PRDX5_HUMAN "Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379] LLADPTGAFGK 1 5.1 0.81024 0.0056195 0 11.7626 0 0 0 0 0 0 0 0 0 0 P30050 RL12_HUMAN Large ribosomal subunit protein uL11 (60S ribosomal protein L12) RPL12 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069] large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ELSGTIK;IGPLGLSPK;KVGDDIAK;QAQIEVVPSASALIIK 4 24.2 0 9.0448 12.3382 13.021 11.9273 9.68108 9.28193 9.78375 12.4913 11.9437 11.9415 11.0702 8.8755 11.7971 P30050 RL12_HUMAN Large ribosomal subunit protein uL11 (60S ribosomal protein L12) RPL12 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069] large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ELSGTIK;IGPLGLIEVVPSASALIIKALK 2 22 0.82877 -0.025381 0 0 0 0 6.94052 0 0 0 0 0 0 0 P30084 ECHM_HUMAN "Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)" ECHS1 Homo sapiens (Human) branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-hydroxypropionyl-CoA dehydratase activity [GO:0043956]; crotonyl-CoA hydratase activity [GO:0120092]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300] AQFAQPEILIGTIPGAGGTQR;EGMTAFVEK;ISAQDAK 3 12.8 0.91063 -0.29462 0 0 0 9.53961 9.06013 8.94524 0 0 0 0 9.36459 0 P30085 KCY_HUMAN UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) CMPK1 CMK CMPK UCK UMK UMPK Homo sapiens (Human) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; nucleobase-containing small molecule interconversion [GO:0015949]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] (d)CMP kinase activity [GO:0004127]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; UMP kinase activity [GO:0033862]; uridine kinase activity [GO:0004849] IVEEMDQTMAANAQKNK 1 11.6 0.92159 -0.4391 0 0 0 0 8.36225 0 9.31488 8.75572 0 0 0 0 P30086 PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] PEBP1 PBP PEBP Homo sapiens (Human) negative regulation of MAPK cascade [GO:0043409] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; phosphatidylethanolamine binding [GO:0008429]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867] GNDISSGTVLSDYVGSGPPK;LYEQLSGK;LYTLVLTDPDAPSR;VLTPTQVK;YVWLVYEQDRPLK 5 33.7 0 7.4516 11.4225 13.8454 0 0 0 0 12.6492 0 0 11.9277 12.1502 0 P30101 PDIA3_HUMAN Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) PDIA3 ERP57 ERP60 GRP58 Homo sapiens (Human) adaptive immune response [GO:0002250]; cellular response to interleukin-7 [GO:0098761]; extrinsic apoptotic signaling pathway [GO:0097191]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; platelet aggregation [GO:0070527]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; Tapasin-ERp57 complex [GO:0061779] cysteine-type endopeptidase activity [GO:0004197]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; phospholipase C activity [GO:0004629]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723] DGEEAGAYDGPR;DPNIVIAK;EATNPPVIQEEKPK;ELSDFISYLQR;FVMQEEFSR;GFPTIYFSPANK;LAPEYEAAATR;LNFAVASR;MDATANDVPSPYEVR;QAGPASVPLR;SEPIPESNDGPVK;TFSHELSDFGLESTAGEIPVVAIR;TVAYTEQK;YGVSGYPTLK 14 32.7 0 49.75 12.7532 12.1004 12.9012 9.82772 11.5792 8.63427 13.2777 14.0799 13.8267 15.275 15.3716 13.2808 P30153 2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Homo sapiens (Human) "chromosome segregation [GO:0007059]; female meiotic nuclear division [GO:0007143]; intracellular signal transduction [GO:0035556]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; negative regulation of hippo signaling [GO:0035331]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein-containing complex assembly [GO:0065003]; regulation of cell differentiation [GO:0045595]; regulation of growth [GO:0040008]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; T cell homeostasis [GO:0043029]" "chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]" protein antigen binding [GO:1990405]; protein heterodimerization activity [GO:0046982]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase activity [GO:0004722] LAGGDWFTSR;MAGDPVANVR;NLCSDDTPMVRR;VLELDNVK 4 6.8 0.0084926 0.9638 0 0 0 0 0 0 11.3465 11.1694 0 10.7485 11.0814 0 P30154 2AAB_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta) PPP2R1B Homo sapiens (Human) apoptotic process involved in morphogenesis [GO:0060561]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] EAATNNLMKLVQK;ELGENLPIEDR;FSELQKAMGPK;LRKLEFPVK 4 6.6 0.97553 -3.4349 0 0 0 8.52411 7.85019 0 0 0 0 0 7.07703 0 P30203 CD6_HUMAN T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] CD6 Homo sapiens (Human) acute inflammatory response to antigenic stimulus [GO:0002438]; adaptive immune response [GO:0002250]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immunological synapse formation [GO:0001771]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of T cell proliferation [GO:0042102]; response to lipopolysaccharide [GO:0032496] cell surface [GO:0009986]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; protein kinase binding [GO:0019901] IENKESR;LPPWNPQVFSSER;SNSESSTSSGEDYCNSPK;VTCAENR 4 6.7 0.95529 -0.87992 0 9.38726 4.75569 0 0 0 0 5.6571 5.39616 0 0 0 P30273 FCERG_HUMAN High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma) FCER1G Homo sapiens (Human) antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; defense response to bacterium [GO:0042742]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway [GO:0038094]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; interleukin-3-mediated signaling pathway [GO:0038156]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of phagocytosis [GO:0050766]; receptor internalization [GO:0031623]; regulation of platelet activation [GO:0010543]; T cell differentiation involved in immune response [GO:0002292] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; Fc-gamma receptor III complex [GO:0033001]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] identical protein binding [GO:0042802]; IgE binding [GO:0019863]; IgE receptor activity [GO:0019767]; IgG binding [GO:0019864]; protein homodimerization activity [GO:0042803] NQETYETLKHEKPPQ 1 17.4 0.91746 -0.42856 0 0 0 8.27682 0 0 0 0 0 0 0 0 P30279 CCND2_HUMAN G1/S-specific cyclin-D2 CCND2 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to X-ray [GO:0071481]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term memory [GO:0007616]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein phosphorylation [GO:0001934] chromatin [GO:0000785]; cyclin D2-CDK4 complex [GO:0097129]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901] KLPQQREK 1 2.8 0.97789 -1.513 0 0 0 0 8.51471 0 0 0 0 0 0 0 P30291 WEE1_HUMAN Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) WEE1 Homo sapiens (Human) cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; neuron projection morphogenesis [GO:0048812]; positive regulation of DNA replication [GO:0045740] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] ISSPQVEEGDSR;LFDTPHTPK;LIGKKMNR 3 4.5 0.95522 -0.87669 11.4206 0 0 0 9.95434 10.152 0 0 0 0 0 0 P30304 MPIP1_HUMAN M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) CDC25A Homo sapiens (Human) cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of DNA replication [GO:0045740]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein-folding chaperone binding [GO:0051087]" DLFTQRQNSAPAR;YVRERDR 2 3.8 0.97962 -1.8433 0 10.2943 0 0 0 0 0 0 0 0 11.6215 0 P30305 MPIP2_HUMAN M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) CDC25B CDC25HU2 Homo sapiens (Human) cell division [GO:0051301]; female meiosis I [GO:0007144]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" DTPVQNKRR;NEQFAIR 2 2.8 0.94674 -0.65756 0 0 0 0 0 0 0 12.5141 0 0 0 0 P30307 MPIP3_HUMAN M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) CDC25C Homo sapiens (Human) cell division [GO:0051301]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; WW domain binding [GO:0050699]" QVEKFKDNTIPDK;SGLYRSPSMPENLNRPR;VQEGERQLR 3 8.2 0.97711 -2.1727 0 0 0 0 7.2266 0 0 12.1731 0 0 0 0 P30405 PPIF_HUMAN "Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)" PPIF CYP3 Homo sapiens (Human) "apoptotic mitochondrial changes [GO:0008637]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; mitochondrial depolarization [GO:0051882]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of oxidative phosphorylation uncoupler activity [GO:2000276]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein folding [GO:0006457]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of proton-transporting ATPase activity, rotational mechanism [GO:0010849]; response to ischemia [GO:0002931]; skeletal muscle fiber differentiation [GO:0098528]" cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739] cyclosporin A binding [GO:0016018]; peptide binding [GO:0042277]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] CGSRWLGLLSVPR;FPDENFTLK;MLALRCGSRWLGLLSVPR 3 13 0.95215 -0.77135 0 11.178 7.66711 8.62509 0 0 0 6.16159 0 0 0 0 P30414 NKTR_HUMAN NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) NKTR Homo sapiens (Human) protein folding [GO:0006457] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] DDDSQSR;DVTKNSK;DWSKSDK;FLLRRDMPVVTAEPEPK;KNYAGSK;RRILIPSDIESSK;RTLKENLSDHLR;SDSYHRGRSYNR;SVDSSAKR;SWSYNGYYSDLSTARHSGHHK;TLKENLSDHLR;VLGEVGK;WKPGQKPWKPSYER 13 9 0.97646 -5.3864 13.8441 6.84172 9.29909 11.1489 0 9.46326 11.1582 0 8.02846 0 8.93493 0 P30518 V2R_HUMAN Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) AVPR2 ADHR DIR DIR3 V2R Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; renal water retention [GO:0003092]; response to cytokine [GO:0034097]; telencephalon development [GO:0021537] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] vasopressin receptor activity [GO:0005000] AELALLSIVFVAVALSNGLVLAALAR 1 7 0.90863 -0.3021 0 0 0 0 0 0 0 0 9.05943 0 0 0 P30519 HMOX2_HUMAN Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form] HMOX2 HO2 Homo sapiens (Human) heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872] ETLEDGFPVHDGK 1 4.1 0.89688 -0.23717 10.4519 0 0 0 0 0 0 0 0 0 0 0 P30520 PURA2_HUMAN "Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)" ADSS2 ADSS Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to ammonium ion [GO:0060359]; response to purine-containing compound [GO:0014074] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301] SIYPTLEIDIEGELQKLK 1 3.9 0.88176 -0.16417 8.7341 8.74487 0 7.15381 0 0 0 0 7.32148 0 0 8.25413 P30530 UFO_HUMAN Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) AXL UFO Homo sapiens (Human) animal organ regeneration [GO:0031100]; blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; response to axon injury [GO:0048678]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; vagina development [GO:0060068]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylserine binding [GO:0001786]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] GTQAEESPFVGNPGNITGAR;MAWRCPR 2 3 0.96661 -1.2648 0 10.8103 0 0 0 0 0 0 0 0 0 0 P30532 ACHA5_HUMAN Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 NACHRA5 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] ALRLLLLVQLVAGR;CGLAGAAGGAQR 2 5.6 0.95455 -0.78598 0 0 12.464 0 0 0 0 0 0 0 2.24071 0 P30533 AMRP_HUMAN Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) LRPAP1 A2MRAP Homo sapiens (Human) amyloid-beta clearance by transcytosis [GO:0150093]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of receptor internalization [GO:0002091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; positive regulation of amyloid-beta clearance [GO:1900223]; regulation of receptor-mediated endocytosis [GO:0048259]; signal transduction [GO:0007165] cell surface [GO:0009986]; cis-Golgi network [GO:0005801]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; rough endoplasmic reticulum lumen [GO:0048237] amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; very-low-density lipoprotein particle receptor binding [GO:0070326] TEEIHENVISPSDLSDIK 1 5 0.84253 -0.052379 0 0 0 9.80678 9.96564 0 0 0 0 0 0 0 P30550 GRPR_HUMAN Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) GRPR Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; motor behavior [GO:0061744]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; regulation of cell population proliferation [GO:0042127]; response to external biotic stimulus [GO:0043207]; social behavior [GO:0035176] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] SYHYSEVDTSMLHFVTSICAR 1 5.5 0.65371 0.16939 0 0 0 0 0 0 0 0 5.33385 0 0 0 P30556 AGTR1_HUMAN Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B Homo sapiens (Human) angiotensin-activated signaling pathway [GO:0038166]; blood vessel diameter maintenance [GO:0097746]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; renin-angiotensin regulation of aldosterone production [GO:0002018]; Rho protein signal transduction [GO:0007266]; symbiont entry into host cell [GO:0046718] membrane [GO:0016020]; plasma membrane [GO:0005886] angiotensin type I receptor activity [GO:0001596]; angiotensin type II receptor activity [GO:0004945]; bradykinin receptor binding [GO:0031711]; protein heterodimerization activity [GO:0046982] NKPRNDDIFK;TMLVAKVTCIIIWLLAGLASLPAIIHR 2 10.3 0.92583 -0.45251 0 9.45865 0 0 0 0 0 0 9.35509 0 0 0 P30559 OXYR_HUMAN Oxytocin receptor (OT-R) OXTR Homo sapiens (Human) "cell surface receptor signaling pathway [GO:0007166]; cellular response to hormone stimulus [GO:0032870]; digestive tract development [GO:0048565]; eating behavior [GO:0042755]; ERK1 and ERK2 cascade [GO:0070371]; estrous cycle [GO:0044849]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; lactation [GO:0007595]; maternal behavior [GO:0042711]; maternal process involved in parturition [GO:0060137]; memory [GO:0007613]; muscle contraction [GO:0006936]; positive regulation of blood pressure [GO:0045777]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of penile erection [GO:0060406]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; suckling behavior [GO:0001967]; telencephalon development [GO:0021537]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886] ionotropic glutamate receptor binding [GO:0035255]; oxytocin receptor activity [GO:0004990]; peptide hormone binding [GO:0017046]; vasopressin receptor activity [GO:0005000] FYGPDLLCR;YLQVVGMFASTYLLLLMSLDRCLAICQPLRSLR 2 10.8 0.91818 -0.40593 0 0 10.8571 0 0 0 0 0 0 9.00784 0 0 P30613 KPYR_HUMAN Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) PKLR PK1 PKL Homo sapiens (Human) cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; pyruvate biosynthetic process [GO:0042866]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to metal ion [GO:0010038]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; pyruvate kinase complex [GO:1902912] ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] EAVESFAGSPLSYRPVAIALDTK;GDLGIEIPAEK;GDLGIEIPAEKVFLAQK;GNANTVWVDYPNIVR 4 9.6 0.89216 -0.21304 0 0 0 0 8.6466 0 0 0 0 6.09725 0 0 P30622 CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) CLIP1 CYLN1 RSN Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; positive regulation of microtubule polymerization [GO:0031116] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] EENSGLLQELEELR;EIKALYTATEK;EKENSLEAIRSK;GDLEVATVSEK;IGFPSTTPAK;LDYQHEIENLQNQQDSER;LENDIAEIMK;LSKENESLK;NVEELNK;VIDNFTSQLK 10 8 0.97606 -4.4969 9.70575 0 8.02375 6.15492 7.60028 4.85977 11.967 8.3486 0 10.5621 0 12.0229 P30626 SORCN_HUMAN Sorcin (22 kDa protein) (CP-22) (CP22) (V19) SRI Homo sapiens (Human) action potential [GO:0001508]; calcium ion transport [GO:0006816]; heart development [GO:0007507]; intracellular sequestering of iron ion [GO:0006880]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart contraction [GO:0008016]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of striated muscle contraction [GO:0006942]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] ALTDSFR;LSPQAVNSIAK;SGTVDPQELQK 3 14.6 0 2.3648 9.56169 11.4253 0 0 0 0 9.82914 10.1339 9.01229 11.2485 0 0 P30679 GNA15_HUMAN Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16) GNA15 GNA16 Homo sapiens (Human) action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] AAARVDQEINR;KGFRPLVYQNIFVSMR;YAAAMQWLWR 3 9.9 0.18524 0.33723 0 0 0 0 0 0 7.0082 0 0 4.61371 0 9.72448 P30740 ILEU_HUMAN Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) SERPINB1 ELANH2 MNEI PI2 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of interleukin-1 beta production [GO:0032691]; type B pancreatic cell proliferation [GO:0044342] collagen-containing extracellular matrix [GO:0062023]; cytolytic granule [GO:0044194]; cytoplasmic ribonucleoprotein granule [GO:0036464]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] peptidase inhibitor activity [GO:0030414]; serine-type endopeptidase inhibitor activity [GO:0004867] LGVQDLFNSSK;LYGEKTYNFLPEFLVSTQK;TVKMMYQK 3 10 0.95366 -0.92755 0 7.48027 0 9.65644 9.21985 0 0 0 10.0869 0 0 0 P30793 GCH1_HUMAN GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) GCH1 DYT5 GCH Homo sapiens (Human) dihydrobiopterin metabolic process [GO:0051066]; dopamine biosynthetic process [GO:0042416]; negative regulation of blood pressure [GO:0045776]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular senescence [GO:2000773]; neuromuscular process controlling posture [GO:0050884]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of heart rate [GO:0010460]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein-containing complex assembly [GO:0065003]; pteridine-containing compound biosynthetic process [GO:0042559]; regulation of blood pressure [GO:0008217]; regulation of lung blood pressure [GO:0014916]; regulation of removal of superoxide radicals [GO:2000121]; response to lipopolysaccharide [GO:0032496]; response to pain [GO:0048265]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; vasodilation [GO:0042311] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270] QVLGLSKLARIVEIYSR 1 6.8 0.53864 0.18548 0 0 0 0 0 0 11.1255 0 0 0 0 0 P30825 CTR1_HUMAN High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) SLC7A1 ATRC1 ERR REC1L Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618] FLANVNDRTK;VIYAMAEDGLLFK 2 3.7 0.94475 -0.63705 0 0 0 0 0 0 0 0 0 0 0 9.65342 P30838 AL3A1_HUMAN "Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)" ALDH3A1 ALDH3 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479] SLKEFYGEDAK 1 2.4 0.92122 -0.44452 0 0 0 0 0 0 0 0 0 0 0 3.51639 P30872 SSR1_HUMAN Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SST1) (SRIF-2) SSTR1 Homo sapiens (Human) "cellular response to estradiol stimulus [GO:0071392]; cellular response to leukemia inhibitory factor [GO:1990830]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]" neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] VVNLGVWVLSLLVILPIVVFSR 1 5.6 0.68197 0.1655 0 0 0 6.17227 5.66069 0 0 0 7.14883 0 0 0 P30876 RPB2_HUMAN DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) POLR2B Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366] "membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; RNA-dependent RNA polymerase activity [GO:0003968] DCQIAHGAAQFLR;DPEQLMNTLRK;IVATLPYIKQEVPIIIVFR;IYAQKFIDR;MTIGHLIECLQGK;SVFYRSYK 6 6.2 0.97501 -3.903 8.13638 0 0 0 0 9.48742 10.8478 0 0 9.45648 0 0 P30939 5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) HTR1F HTR1EL Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] EEVNGQVLLESGEK 1 3.8 0.87281 -0.1092 0 0 0 0 9.17 0 0 0 0 0 0 0 P30954 O10J1_HUMAN Olfactory receptor 10J1 (Olfactory receptor OR1-26) (Olfactory receptor-like protein HGMP07J) OR10J1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; single fertilization [GO:0007338] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IASVEGRKK 1 2.8 0.97751 -1.4933 0 13.2451 0 0 0 0 0 0 0 0 0 0 P30988 CALCR_HUMAN Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor 1 signaling pathway [GO:0150059]; amylin receptor 2 signaling pathway [GO:0150060]; amylin receptor 3 signaling pathway [GO:0150061]; amylin receptor signaling pathway [GO:0097647]; calcitonin family receptor signaling pathway [GO:0097646]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384] acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929]; plasma membrane [GO:0005886] amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin family receptor activity [GO:0097642]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948] ETHEAESHMYLK 1 2.5 0.8839 -0.17208 0 10.3624 0 0 0 0 0 0 0 0 0 0 P30988 CALCR_HUMAN Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor 1 signaling pathway [GO:0150059]; amylin receptor 2 signaling pathway [GO:0150060]; amylin receptor 3 signaling pathway [GO:0150061]; amylin receptor signaling pathway [GO:0097647]; calcitonin family receptor signaling pathway [GO:0097646]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384] acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929]; plasma membrane [GO:0005886] amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin family receptor activity [GO:0097642]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948] LRWYYLLGWAPAFHR;WYYLLGWAPAFHR 2 5.5 0.91767 -0.40709 0 0 0 0 0 0 0 0 0 0 6.78359 9.92585 P30989 NTR1_HUMAN Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH) NTSR1 NTRR Homo sapiens (Human) adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; response to lipid [GO:0033993]; temperature homeostasis [GO:0001659] cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195] G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] AVVIAFVVCWLPYHVRR;LNSSAPGTPGTPAADPFQR 2 8.6 0.41141 0.20396 0 0 11.4722 6.70446 0 0 0 0 0 0 0 0 P31040 SDHA_HUMAN "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-)" SDHA SDH2 SDHF Homo sapiens (Human) "mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; nervous system development [GO:0007399]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; succinate dehydrogenase (quinone) activity [GO:0008177] FADGSIR;GVIALCIEDGSIHR 2 3.2 0.92402 -0.44974 0 0 0 0 0 0 8.95675 0 0 9.10211 0 9.20587 P31150 GDIA_HUMAN Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) GDI1 GDIL OPHN2 RABGDIA XAP4 Homo sapiens (Human) negative regulation of axonogenesis [GO:0050771]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of axon extension [GO:0045773]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; response to calcium ion [GO:0051592]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; midbody [GO:0030496]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; small GTPase binding [GO:0031267] DWNVDLIPK;FLMANGQLVK;IICILSHPIK;LYSESLAR;MLLYTEVTR;SPYLYPLYGLGELPQGFAR 6 14.5 0.80451 0.013884 0 0 0 0 0 0 0 0 8.79113 0 0 14.5461 P31153 METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) MAT2A AMS2 MATA2 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to methionine [GO:0061431]; one-carbon metabolic process [GO:0006730]; positive regulation of TORC1 signaling [GO:1904263]; protein heterooligomerization [GO:0051291]; protein hexamerization [GO:0034214]; S-adenosylmethionine biosynthetic process [GO:0006556] cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]; small molecule binding [GO:0036094] FVIGGPQGDAGLTGR;SAAYAAR;VACETVAK 3 7.6 0.97547 -1.4401 0 0 0 0 8.50498 0 0 0 0 9.86578 0 0 P31249 HXD3_HUMAN Homeobox protein Hox-D3 (Homeobox protein Hox-4A) HOXD3 HOX1D HOX4A Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; cell-matrix adhesion [GO:0007160]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; glossopharyngeal nerve morphogenesis [GO:0021615]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; thyroid gland development [GO:0030878] aggresome [GO:0016235]; chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" SPPGPASK 1 1.9 0.74488 0.10231 10.0389 0 0 0 0 0 0 0 0 0 0 0 P31268 HXA7_HUMAN Homeobox protein Hox-A7 (Homeobox protein Hox 1.1) (Homeobox protein Hox-1A) HOXA7 HOX1A Homo sapiens (Human) angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863] chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ADEEDDDEEEEDEEE;QTYTRYQTLELEK 2 12.2 0.66014 0.16912 4.34731 0 0 0 0 0 0 0 0 0 0 0 P31270 HXA11_HUMAN Homeobox protein Hox-A11 (Homeobox protein Hox-1I) HOXA11 HOX1I Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; developmental growth [GO:0048589]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal joint morphogenesis [GO:0060272]; male gonad development [GO:0008584]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; organ induction [GO:0001759]; positive regulation of cell development [GO:0010720]; positive regulation of chondrocyte development [GO:1902761]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to testosterone [GO:0033574]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ETAAAAEEKERR;LQYYSANPLL 2 7 0.94421 -0.62616 0 0 0 0 0 0 0 10.2209 0 0 0 0 P31271 HXA13_HUMAN Homeobox protein Hox-A13 (Homeobox protein Hox-1J) HOXA13 HOX1J Homo sapiens (Human) artery morphogenesis [GO:0048844]; branching involved in prostate gland morphogenesis [GO:0060442]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindgut morphogenesis [GO:0048619]; endothelial cell fate specification [GO:0060847]; endothelial cell morphogenesis [GO:0001886]; inner ear development [GO:0048839]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mitotic nuclear division [GO:0140014]; positive regulation of mesenchymal cell apoptotic process [GO:2001055]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of BMP signaling pathway [GO:0030510]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular septum development [GO:0003281] chromatin [GO:0000785]; chromosome [GO:0005694]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ISATTNLSER;VPYTKVQLK 2 4.9 0.98076 -1.742 0 0 0 0 10.5436 0 0 0 0 11.0159 0 0 P31321 KAP1_HUMAN cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; learning or memory [GO:0007611]; negative regulation of cAMP/PKA signal transduction [GO:0141162]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of fear response [GO:1903367]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of synaptic vesicle cycle [GO:0098693] cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685] cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase A catalytic subunit binding [GO:0034236] VSILESLEKWER 1 3.1 0.28174 0.25365 0 5.27605 0 0 0 0 0 0 10.4914 0 0 0 P31327 CPSM_HUMAN "Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)" CPS1 Homo sapiens (Human) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094] AADTIGYPVMIR;AFAISGPFNVQFLVK;AFAMTNQILVEK;AIDDNMSLDEIEK;APMFSWPR;AQTAHIVLEDGTK;ATGYPLAFIAAK;ATTITSVLPKPALVASR;AVNTLNEALEFAK;DADPILR;DGSIDLVINLPNNNTK;EIEYEVVR;EIGFSDK;ELSEPSSTR;EPLFGISTGNLITGLAAGAK;ETLMDLSTK;EVEMDAVGK;FLEEATR;GLNSESMTEETLKR;GQILTMANPIIGNGGAPDTTALDELGLSK;GQNQPVLNITNK;IALGIPLPEIK;IALGIPLPEIKNVVSGK;IAPSFAVESIEDALK;ILTAFKVVRTLK;IMGTSPLQIDR;LFAEAVQK;MEYDGILIAGGPGNPALAEPLIQNVR;NIHPWVK;QLFSDKLNEINEK;SFPFVSK;SIFSAVLDELK;SVGEVMAIGR;TAVDSGIPLLTNFQVTK;TFEESFQK;TLGVDFIDVATK;TSINVVR;TVLMNPNIASVQTNEVGLK;VAQAPWK;VLGTSVESIMATEDR;VMIGENVDEK;VPAIYGVDTR;VSQEHPVVLTK;YLESNGIK 44 34.9 0 169.73 7.29655 0 5.80542 0 8.69199 0 16.1311 16.3583 16.4235 15.8474 15.2467 0 P31350 RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) RRM2 RR2 Homo sapiens (Human) 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; blastocyst development [GO:0001824]; deoxyribonucleotide biosynthetic process [GO:0009263]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185] cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoside-diphosphate reductase complex [GO:0005971] "ferric iron binding [GO:0008199]; protein homodimerization activity [GO:0042803]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" EIIINAVR;EREFLFNAIETMPCVKK;VGGMAQPMGR 3 7.8 0.95507 -0.97389 8.70363 0 0 0 0 0 0 0 0 5.94031 9.90676 0 P31371 FGF9_HUMAN Fibroblast growth factor 9 (FGF-9) (Glia-activating factor) (GAF) (Heparin-binding growth factor 9) (HBGF-9) FGF9 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell proliferation [GO:0060038]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; mesenchymal cell proliferation [GO:0010463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; negative regulation of Wnt signaling pathway [GO:0030178]; neurogenesis [GO:0022008]; osteoblast differentiation [GO:0001649]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein import into nucleus [GO:0006606]; regulation of cell migration [GO:0030334]; regulation of timing of cell differentiation [GO:0048505]; Sertoli cell proliferation [GO:0060011]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201] EQFEENWYNTYSSNLYKHVDTGR;GVDSGLYLGMNEK 2 17.3 0.95526 -0.90143 0 0 0 0 0 0 0 0 0 10.9426 11.6994 0 P31431 SDC4_HUMAN Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) SDC4 Homo sapiens (Human) cell migration [GO:0016477]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of stress fiber assembly [GO:0051496]; regulation of fibroblast migration [GO:0010762]; ureteric bud development [GO:0001657]; wound healing [GO:0042060] cell surface [GO:0009986]; costamere [GO:0043034]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080]; thrombospondin receptor activity [GO:0070053] LEENEVIPKR 1 5.1 0.47615 0.19057 0 0 0 0 0 0 0 0 0 0 0 4.54158 P31512 FMO4_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4) FMO4 FMO2 Homo sapiens (Human) energy homeostasis [GO:0097009]; negative regulation of fatty acid oxidation [GO:0046322]; xenobiotic catabolic process [GO:0042178] endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" CCVDEDLEPTCFER;GSILSGTELQAR 2 4.7 0.95296 -0.67447 0 0 0 0 0 0 0 3.42841 0 0 0 0 P31513 FMO3_HUMAN Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) FMO3 Homo sapiens (Human) taurine biosynthetic process [GO:0042412] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "albendazole monooxygenase activity [GO:0047638]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" GKKVAIIGAGVSGLASIR;GTCTLPSMEDMMNDINEKMEK;LFAIPILLIAVFLVLT;TAEQVMISSR 4 12.2 0.96336 -1.0844 0 0 12.8139 0 0 0 0 9.79357 0 5.34954 0 0 P31629 ZEP2_HUMAN Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) HIVEP2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DNSPKRYLIPK;KWEDSETPK;QEQSAVIKMSTFGSHEGQR;VGYDYDVCRKPYK 4 2.1 0.97518 -3.183 0 0 0 0 0 12.1464 8.41164 9.41278 0 11.6484 0 0 P31639 SC5A2_HUMAN Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) SLC5A2 SGLT2 Homo sapiens (Human) alpha-glucoside transport [GO:0000017]; carbohydrate metabolic process [GO:0005975]; D-glucose import across plasma membrane [GO:0098708]; hexose transmembrane transport [GO:0008645]; renal D-glucose absorption [GO:0035623]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; D-glucose:sodium symporter activity [GO:0005412]; low-affinity D-glucose:sodium symporter activity [GO:0005362]; metal ion binding [GO:0046872] RIRLYLSVLSLFLYIFTK 1 2.7 0.57206 0.18154 0 0 0 0 0 0 0 0 9.05934 0 0 0 P31641 SC6A6_HUMAN Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Homo sapiens (Human) alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]; import across plasma membrane [GO:0098739]; modulation of chemical synaptic transmission [GO:0050804]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; positive regulation of cell differentiation [GO:0045597]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; postsynaptic membrane [GO:0045211] alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369] GVRSTGK;NVLSLSPGIDHPGSLK;STGKVVYFTATFPFAMLLVLLVR 3 6.8 0.9804 -1.8025 0 0 0 0 0 0 10.7411 0 0 0 0 0 P31644 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5) GABRA5 Homo sapiens (Human) "associative learning [GO:0008306]; behavioral fear response [GO:0001662]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IDKMSRIVFPVLFGTFNLVYWATYLNR;SVVVAEDGSR 2 8 0.87345 -0.10833 0 0 0 0 0 0 7.44444 0 0 0 0 0 P31645 SC6A4_HUMAN Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) SLC6A4 HTT SERT Homo sapiens (Human) "amino acid transport [GO:0006865]; behavioral response to cocaine [GO:0048148]; brain morphogenesis [GO:0048854]; cellular response to cGMP [GO:0071321]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; conditioned place preference [GO:1990708]; enteric nervous system development [GO:0048484]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoamine transport [GO:0015844]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of organ growth [GO:0046621]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; neurotransmitter transport [GO:0006836]; platelet aggregation [GO:0070527]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of serotonin secretion [GO:0014064]; regulation of thalamus size [GO:0090067]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; serotonin uptake [GO:0051610]; sodium ion transmembrane transport [GO:0035725]; sperm ejaculation [GO:0042713]; vasoconstriction [GO:0042310]" endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]; synapse [GO:0045202] actin filament binding [GO:0051015]; antiporter activity [GO:0015297]; cocaine binding [GO:0019811]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation channel activity [GO:0005261]; neurotransmitter transmembrane transporter activity [GO:0005326]; nitric-oxide synthase binding [GO:0050998]; serotonin binding [GO:0051378]; serotonin:sodium:chloride symporter activity [GO:0005335]; sodium ion binding [GO:0031402]; syntaxin-1 binding [GO:0017075] GLQDLGGISWQLALCIMLIFTVIYFSIWK;VVPTPGDK 2 5.9 0.89724 -0.25078 0 0 0 7.65155 0 0 0 0 10.8302 0 0 0 P31689 DNJA1_HUMAN DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; flagellated sperm motility [GO:0030317]; negative regulation of apoptotic process [GO:0043066]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of apoptotic process [GO:0043065]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; protein refolding [GO:0042026]; regulation of protein transport [GO:0051223]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; C3HC4-type RING finger domain binding [GO:0055131]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; low-density lipoprotein particle receptor binding [GO:0050750]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] FKQISQAYEVLSDAKK;GKNVVHQLSVTLEDLYNGATR;LIIEFKVSCNVL;TIVITSHPGQIVK 4 18.7 0.96425 -1.1653 0 0 0 0 0 0 0 9.63992 11.7306 0 10.5231 0 P31749 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) AKT1 PKB RAC Homo sapiens (Human) activation-induced cell death of T cells [GO:0006924]; anoikis [GO:0043276]; apoptotic mitochondrial changes [GO:0008637]; behavioral response to pain [GO:0048266]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell population proliferation [GO:0008283]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to rapamycin [GO:0072752]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to mitochondrion [GO:0072655]; excitatory postsynaptic potential [GO:0060079]; execution phase of apoptosis [GO:0097194]; fibroblast migration [GO:0010761]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of protein location in mitochondrion [GO:0072656]; mammalian oogenesis stage [GO:0022605]; mammary gland epithelial cell differentiation [GO:0060644]; maternal placenta development [GO:0001893]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of cilium assembly [GO:1902018]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of macroautophagy [GO:0016242]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of protein maturation [GO:1903318]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nitric oxide biosynthetic process [GO:0006809]; osteoblast differentiation [GO:0001649]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peripheral nervous system myelin maintenance [GO:0032287]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of D-glucose import [GO:0046326]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of mRNA stability [GO:0043488]; regulation of myelination [GO:0031641]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tRNA methylation [GO:0110002]; regulation of type B pancreatic cell development [GO:2000074]; response to fluid shear stress [GO:0034405]; response to food [GO:0032094]; response to growth factor [GO:0070848]; response to growth hormone [GO:0060416]; response to heat [GO:0009408]; response to insulin-like growth factor stimulus [GO:1990418]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; striated muscle cell differentiation [GO:0051146]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929]; virus-mediated perturbation of host defense response [GO:0019049] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; vesicle [GO:0031982] "14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; nitric-oxide synthase regulator activity [GO:0030235]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; potassium channel activator activity [GO:0099104]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" ATGRYYAMK;VILVKEKATGR 2 3.3 0.76512 0.063317 0 0 0 0 0 0 11.0883 0 0 0 0 0 P31751 AKT2_HUMAN RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) AKT2 Homo sapiens (Human) cellular response to high light intensity [GO:0071486]; cellular response to insulin stimulus [GO:0032869]; fat cell differentiation [GO:0045444]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of D-glucose import [GO:0046326]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; protein modification process [GO:0036211]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; retinal rod cell apoptotic process [GO:0097473]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ATGRYYAMK;FPRTLSPEAKSLLAGLLK;TLSPEAK 3 5.6 0.97401 -2.9969 0 0 0 0 0 0 9.24465 10.3944 0 0 0 0 P31785 IL2RG_HUMAN Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) IL2RG Homo sapiens (Human) "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cellular homeostasis [GO:0019725]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; lymphocyte differentiation [GO:0030098]; mature B cell differentiation [GO:0002335]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell differentiation in thymus [GO:0033089]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]" cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976] GLAESLQPDYSER;RQATQMLKLQNLVIPWAPENLTLHK 2 10.3 0.66882 0.16893 0 0 0 0 0 0 0 0 0 0 10.2509 0 P31785 IL2RG_HUMAN Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) IL2RG Homo sapiens (Human) "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cellular homeostasis [GO:0019725]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; lymphocyte differentiation [GO:0030098]; mature B cell differentiation [GO:0002335]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell differentiation in thymus [GO:0033089]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]" cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976] GLAESLQPDYSER;MGMKTPQLEQSVDYRHK 2 16.8 0.36989 0.2264 0 0 4.14543 0 0 0 0 10.6402 0 8.83517 0 0 P31930 QCR1_HUMAN "Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)" UQCRC1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; ubiquitin protein ligase binding [GO:0031625] FTGSEIR 1 1.5 0.88318 -0.17508 0 0 0 0 0 0 0 0 0 0 9.92552 0 P31939 PUR9_HUMAN "Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]" ATIC PURH OK/SW-cl.86 Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; animal organ regeneration [GO:0031100]; brainstem development [GO:0003360]; cellular response to interleukin-7 [GO:0098761]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dihydrofolate metabolic process [GO:0046452]; GMP biosynthetic process [GO:0006177]; nucleobase-containing compound metabolic process [GO:0006139]; tetrahydrofolate biosynthetic process [GO:0046654] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643]; protein homodimerization activity [GO:0042803] DAGLAVR;EVSDGIIAPGYEEEALTILSK;IHCTRLAGDK;IHCTRLAGDKANYWWLR;NGQVIGIGAGQQSR;NKDLPESALR;NLTALGLNLVASGGTAK;QYSKGVSQMPLR;TLTPISAAYAR;TVASPGVTVEEAVEQIDIGGVTLLR 10 22.6 0 1.9413 12.9462 11.8314 12.5277 9.21587 8.15183 8.30611 11.8375 0 6.79883 0 6.19902 0 P31942 HNRH3_HUMAN Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) HNRNPH3 HNRPH3 Homo sapiens (Human) "epithelial cell differentiation [GO:0030855]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] ATENDIANFFSPLNPIR;DGMDNQGGYGSVGR;EIAENALGK;GLPFRATENDIANFFSPLNPIR;GSMYDRMRR;STGEAFVQFASK 6 19.1 0 3.3291 10.0418 11.1266 10.6703 10.4836 10.0831 10.6414 12.0239 9.94134 11.8279 11.6147 11.1684 11.4083 P31942 HNRH3_HUMAN Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) HNRNPH3 HNRPH3 Homo sapiens (Human) "epithelial cell differentiation [GO:0030855]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] ATENDIANFFSPLNPIR;DGMDNQGGYGSVGR;EIAENALGK;GLPFRATENDIANFFSPLNPIR;GSYGGFDDYGGYNNYGYGNDGFDDR;STGEAFVQFASK 6 24.8 0.71253 0.15167 0 0 5.78432 0 0 0 7.70694 0 0 0 0 0 P31943 HNRH1_HUMAN "Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]" HNRNPH1 HNRPH HNRPH1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] ATENDIYNFFSPLNPVR;GAYGGGYGGYDDYNGYNDGYGFGSDR;HTGPNSPDTANDGFVR;IQNGAQGIR;MLGTEGGEGFVVK;MMLGTEGGEGFVVK;SNNVEMDWVLK;STGEAFVQFASQEIAEK;VTGEADVEFATHEDAVAAMSK 9 29.2 0 119.08 12.6763 13.2039 12.8493 9.10983 10.4161 9.04906 12.8726 11.6949 12.8551 12.5352 12.624 13.5067 P31944 CASPE_HUMAN "Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" CASP14 Homo sapiens (Human) cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type endopeptidase activity [GO:0004197] HDQKGSCFIQTLVDVFTK;TNPEIQSTLRKR 2 12.4 0.97618 -2.2543 0 0 0 0 0 0 0 0 0 9.41437 0 0 P31946 1433B_HUMAN "14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]" YWHAB Homo sapiens (Human) cytoplasmic sequestering of protein [GO:0051220]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; protein localization [GO:0008104]; protein targeting [GO:0006605]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774] cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864] AVTEQGHELSNEER;DSTLIMQLLR;LAEQAER;LAEQAERYDDMAAAMK;MDKSELVQK;NLLSVAYK;VFYLKMKGDYFR;YDDMAAAMK;YLSEVASGDNK 9 32.8 0 2.3584 12.2082 11.3352 0 0 0 0 0 0 0 12.0942 12.1732 6.77584 P31947 1433S_HUMAN 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) SFN HME1 Homo sapiens (Human) cAMP/PKA signal transduction [GO:0141156]; establishment of skin barrier [GO:0061436]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of innate immune response [GO:0045824]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization [GO:1903829]; protein export from nucleus [GO:0006611]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of cell-cell adhesion [GO:0022407]; regulation of epidermal cell division [GO:0010482]; regulation of protein localization [GO:0032880]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction [GO:0007165]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoserine residue binding [GO:0050815]; protein kinase binding [GO:0019901]; protein kinase C inhibitor activity [GO:0008426]; protein sequestering activity [GO:0140311] DNLTLWTADNAGEEGGEAPQEPQS;DSTLIMQLLR;EMPPTNPIR;LAEQAER;NLLSVAYK;NVVGGQR;VLSSIEQK 7 29.4 0.88721 -0.18284 13.6428 13.7575 13.6352 0 0 0 0 0 0 14.0456 14.4165 0 P31948 STIP1_HUMAN Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) cellular response to interleukin-7 [GO:0098761] cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991] Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723] AAALEAMKDYTK;DFDTALK;DPQALSEHLK;EAADGYQR;HDSPEDVK;IGNSYFK;LAYINPDLALEEK;MEQVNELKEK;NKPSDLGTK;RTYEEGLK;SLAEHRTPDVLK;SLAEHRTPDVLKK 12 19.3 0.71671 0.13638 0 0 0 0 10.3707 10.066 11.9711 0 12.4701 11.1402 10.7683 0 P31948 STIP1_HUMAN Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) cellular response to interleukin-7 [GO:0098761] cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991] Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723] AAALEAMKDYTK;DFDTALK;DPQALSEHLK;EAADGYQR;HDSPEDVK;IGNSYFK;LAYINPDLALEEK;NKPSDLGTK;RTYEEGLK;SLAEHRTPDVLK;SLAEHRTPDVLKK;WVNELKEK 12 17.5 0.91362 -0.33804 0 0 0 0 8.11801 0 0 0 0 9.17956 0 0 P31949 S10AB_HUMAN "Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]" S100A11 MLN70 S100C Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of smooth muscle cell migration [GO:0014911]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774] cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548] DGYNYTLSKTEFLSFMNTELAAFTK;DPGVLDR;DPGVLDRMMK;ISSPTETER;TEFLSFMNTELAAFTK 5 41.9 0 5.1104 9.41179 9.93905 9.02755 0 0 7.0735 8.21111 8.29094 5.93452 11.6458 12.2062 9.72306 P31994 FCG2B_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32) FCGR2B CD32 FCG2 IGFR2 Homo sapiens (Human) "antibody-dependent cellular cytotoxicity [GO:0001788]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to molecule of bacterial origin [GO:0071219]; cerebellum development [GO:0021549]; defense response [GO:0006952]; Fc-gamma receptor signaling pathway [GO:0038094]; follicular B cell differentiation [GO:0002316]; follicular dendritic cell activation [GO:0002266]; immune complex clearance by monocytes and macrophages [GO:0002436]; immune effector process [GO:0002252]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of antibody-dependent cellular cytotoxicity [GO:0001814]; negative regulation of B cell activation [GO:0050869]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of immune response [GO:0050777]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of phagocytosis [GO:0050765]; negative regulation of type I hypersensitivity [GO:0001811]; phagocytosis [GO:0006909]; phagocytosis, engulfment [GO:0006911]; positive regulation of humoral immune response [GO:0002922]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phagocytosis [GO:0050766]; positive regulation of response to endoplasmic reticulum stress [GO:1905898]; positive regulation of tumor necrosis factor production [GO:0032760]; receptor-mediated endocytosis [GO:0006898]; regulation of adaptive immune response [GO:0002819]; regulation of B cell antigen processing and presentation [GO:0002622]; regulation of dendritic spine maintenance [GO:1902950]; regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903381]; regulation of immune complex clearance by monocytes and macrophages [GO:0090264]; regulation of innate immune response [GO:0045088]; regulation of signaling receptor activity [GO:0010469]; response to bacterium [GO:0009617]" cell body [GO:0044297]; dendritic spine [GO:0043197]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; IgG binding [GO:0019864]; IgG receptor activity [GO:0019770]; low-affinity IgG receptor activity [GO:0019772]; protein-containing complex binding [GO:0044877] ISALPGYPECR 1 3.5 0.77908 0.039638 0 0 0 0 3.93725 0 0 0 0 0 0 5.09102 P32004 L1CAM_HUMAN Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) axon development [GO:0061564]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chemotaxis [GO:0006935]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; synapse organization [GO:0050808] axon [GO:0030424]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; protein domain specific binding [GO:0019904] FQGIYRCFASNK;GSRVTFTCQASFDPSLQPSITWRGDGR 2 3.1 0.96687 -1.2923 0 0 0 0 0 0 11.9445 0 0 5.75598 10.4251 0 P32019 I5P2_HUMAN "Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)" INPP5B OCRL2 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]" AQEFIHQFLCNPL;DTIVKSHLLQKEEDYTYIQNFR;LIRLVGIMLLLYVK;NPAGHQK;NPAGHQKLDMTEK 5 6.2 0.96637 -1.2697 0 0 0 0 0 0 10.3827 7.7322 0 6.26512 0 0 P32119 PRDX2_HUMAN Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) PRDX2 NKEFB TDPX1 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway [GO:0097191]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of T cell differentiation [GO:0045581]; positive regulation of blood coagulation [GO:0030194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of hydrogen peroxide metabolic process [GO:0010310]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in inflammatory response [GO:0002536]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymus development [GO:0048538] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379] ATAVVDGAFK;ATAVVDGAFKEVK;EGGLGPLNIPLLADVTR;KEGGLGPLNIPLLADVTR;LSEDYGVLK;QITVNDLPVGR;RLSEDYGVLKTDEGIAYR;SVDEALR;TDEGIAYR 9 33.8 0 21.372 12.4407 11.4335 10.0449 0 0 0 12.7165 12.0002 11.0179 0 11.7068 0 P32121 ARRB2_HUMAN Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) ARRB2 ARB2 ARR2 Homo sapiens (Human) "adult walking behavior [GO:0007628]; cell chemotaxis [GO:0060326]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor internalization [GO:0002031]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; postsynaptic signal transduction [GO:0098926]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]" clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] angiotensin receptor binding [GO:0031701]; D1 dopamine receptor binding [GO:0031748]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; molecular adaptor activity [GO:0060090]; protein kinase B binding [GO:0043422]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625] VDPVDGVVLVDPDYLKDR;VKLVVSR 2 6.1 0.94436 -0.63804 0 0 0 0 9.26468 0 0 0 0 0 0 0 P32238 CCKAR_HUMAN Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR CCKRA Homo sapiens (Human) axonogenesis [GO:0007409]; cellular response to hormone stimulus [GO:0032870]; cholecystokinin signaling pathway [GO:0038188]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of hormone secretion [GO:0046883] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cholecystokinin receptor activity [GO:0004951]; peptide hormone binding [GO:0017046] LELRQLSTGSSSR 1 3 0.92188 -0.44312 0 0 0 0 0 0 0 0 0 0 8.70805 0 P32247 BRS3_HUMAN Bombesin receptor subtype-3 (BRS-3) BRS3 Homo sapiens (Human) adult feeding behavior [GO:0008343]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose metabolic process [GO:0006006]; regulation of blood pressure [GO:0008217] membrane [GO:0016020]; plasma membrane [GO:0005886] bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188] NMTFESCTSYPVSKK;QPSNAILK 2 5.8 0.90971 -0.31226 0 0 0 0 0 0 0 8.27291 0 0 9.69864 0 P32248 CCR7_HUMAN C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) CCR7 CMKBR7 EBI1 EVI1 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; dendritic cell chemotaxis [GO:0002407]; establishment of T cell polarity [GO:0001768]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte migration into lymph node [GO:0097022]; mature conventional dendritic cell differentiation [GO:0097029]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of interleukin-12 production [GO:0032695]; negative thymic T cell selection [GO:0045060]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation [GO:2000526]; positive regulation of humoral immune response [GO:0002922]; positive regulation of hypersensitivity [GO:0002885]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of T cell costimulation [GO:2000525]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of dendritic cell dendrite assembly [GO:2000547]; regulation of interleukin-1 beta production [GO:0032651]; regulation of type II interferon production [GO:0032649]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; ruffle organization [GO:0031529] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] C-C chemokine receptor activity [GO:0016493]; C-C motif chemokine 19 receptor activity [GO:0038117]; C-C motif chemokine 21 receptor activity [GO:0038121]; chemokine (C-C motif) ligand 19 binding [GO:0035757]; chemokine (C-C motif) ligand 21 binding [GO:0035758]; G protein-coupled receptor activity [GO:0004930] DLGCLSQEQLRQWSSCRHIR;TLLQARNFERNK 2 8.5 0.97817 -2.0611 0 0 0 0 0 0 0 0 12.2197 0 0 11.505 P32249 GP183_HUMAN G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2) GPR183 EBI2 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; dendritic cell chemotaxis [GO:0002407]; dendritic cell homeostasis [GO:0036145]; G protein-coupled receptor signaling pathway [GO:0007186]; humoral immune response [GO:0006959]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; mature B cell differentiation involved in immune response [GO:0002313]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of astrocyte chemotaxis [GO:2000458]; T cell chemotaxis [GO:0010818]; T follicular helper cell differentiation [GO:0061470] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142] IAYYAMGFDWR;TAKQNPLTEK 2 5.8 0.95565 -0.85251 0 0 0 0 0 0 0 0 0 0 8.61132 0 P32297 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 NACHRA3 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] ALAVSLPLALSPPRLLLLLLLSLLPVAR;EGYPCQDGMCGYCHHRRIK;EIQDDWKYVAMVIDR 3 12.3 0.92234 -0.44263 0 0 0 0 0 0 9.83178 0 7.21781 10.4129 10.2943 0 P32298 GRK4_HUMAN G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) GRK4 GPRK2L GPRK4 Homo sapiens (Human) receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of opsin-mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254] GEPFEEYQESSYFSQFLQWK;GIYLDTADEDFYAR 2 5.9 0.8697 -0.098789 0 0 0 0 0 0 0 0 9.82923 8.68538 0 0 P32320 CDD_HUMAN Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular response to external biotic stimulus [GO:0071217]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; pyrimidine-containing compound salvage [GO:0008655]; response to cycloheximide [GO:0046898]; UMP salvage [GO:0044206] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] AVSEGYKDFR 1 6.8 0.88832 -0.18341 0 8.31325 0 0 0 0 0 0 0 0 0 0 P32321 DCTD_HUMAN Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) DCTD Homo sapiens (Human) cytidine deamination [GO:0009972]; nucleoside salvage [GO:0043174]; nucleotide biosynthetic process [GO:0009165]; pyrimidine nucleotide metabolic process [GO:0006220] cytoplasm [GO:0005737]; cytosol [GO:0005829] dCMP deaminase activity [GO:0004132]; deoxyribonucleoside 5'-monophosphate N-glycosidase activity [GO:0070694]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] EVIFMSDKYHDSDEATAAR;LLFNMAGVTFRK;SEVSCKK;YHDSDEATAAR 4 21.3 0.95392 -0.91759 0 11.8111 0 7.6111 0 0 0 0 0 0 11.4493 0 P32322 P5CR1_HUMAN "Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)" PYCR1 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; proline biosynthetic process [GO:0006561]; regulation of mitochondrial membrane potential [GO:0051881] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735] DHLPLELGSPEGLHPLLLQYQLAR;RLAVRLGAQALLGAAK;SVGFIGAGQLAFALAK 3 17.7 0 10.94 9.88361 10.047 12.2519 0 6.42309 0 6.76354 0 0 0 0 0 P32418 NAC1_HUMAN Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) SLC8A1 CNC NCX1 Homo sapiens (Human) calcium ion export [GO:1901660]; calcium ion homeostasis [GO:0055074]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to reactive oxygen species [GO:0034614]; intracellular calcium ion homeostasis [GO:0006874]; intracellular sodium ion homeostasis [GO:0006883]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of bone mineralization [GO:0030501]; positive regulation of the force of heart contraction [GO:0098735]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; relaxation of smooth muscle [GO:0044557]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; vascular associated smooth muscle contraction [GO:0014829] axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; cytoskeletal protein binding [GO:0008092]; transmembrane transporter binding [GO:0044325] DQDDEEAR;HAADQAR;RLLFYKYVYK 3 2.6 0.92876 -0.47216 0 0 0 0 3.97205 0 0 0 0 11.4934 0 0 P32455 GBP1_HUMAN Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) GBP1 Homo sapiens (Human) cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein localization to vacuole [GO:0072665]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein localization to plasma membrane [GO:1903076] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; vesicle membrane [GO:0012506] actin binding [GO:0003779]; cytokine binding [GO:0019955]; enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GDP phosphatase activity [GO:0004382]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; membrane scission GTPase motor activity [GO:1990606]; protein homodimerization activity [GO:0042803]; spectrin binding [GO:0030507] EKEIEVERVK;KNEQMMEQKER 2 3.5 0.836 -0.02986 0 0 0 0 0 9.66313 0 0 0 8.78748 0 0 P32456 GBP2_HUMAN Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2) GBP2 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803] DIWDIQMR;DRAQLMAEQEK;DRAQLMAEQEKTLALK 3 4.1 0.98116 -1.7765 9.90454 0 11.4863 0 10.2447 0 0 0 0 0 0 0 P32519 ELF1_HUMAN ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Homo sapiens (Human) negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ENVMLQSQK;LVYQFKEMPK;TLTQEVEKKESEDHLK 3 5.7 0.97553 -1.4377 0 0 0 0 0 0 0 0 10.2916 3.99684 0 0 P32745 SSR3_HUMAN Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28) SSTR3 Homo sapiens (Human) "cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated apoptotic signaling pathway [GO:0008628]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]" ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; signaling receptor binding [GO:0005102]; somatostatin receptor activity [GO:0004994] TEEEDEEEEDGEESR 1 3.6 0.65933 0.16919 0 0 0 5.36107 0 3.55741 0 0 0 0 0 0 P32754 HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) HPD PPD Homo sapiens (Human) L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] IMREPWVEQDK;MTTYSDKGAKPERGR 2 6.6 0.97257 -1.3682 0 0 0 0 0 8.74103 0 0 0 0 0 0 P32780 TF2H1_HUMAN General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) GTF2H1 BTF2 Homo sapiens (Human) DNA repair [GO:0006281]; hormone-mediated signaling pathway [GO:0009755]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966] DLLQQLLPKFKR;FFQSHYFHR;KANKELEEK;MKSNLER 4 6.8 0.97254 -2.7796 7.22891 0 8.03639 0 0 0 12.5408 0 0 0 4.34667 0 P32856 STX2_HUMAN Syntaxin-2 (Epimorphin) STX2 EPIM STX2A STX2B STX2C Homo sapiens (Human) acrosome reaction [GO:0007340]; animal organ morphogenesis [GO:0009887]; cellular response to oxidative stress [GO:0034599]; cornified envelope assembly [GO:1903575]; ectoderm development [GO:0007398]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; structural molecule activity [GO:0005198] KKWIIIAVSVVLVAIIALIIGLSVGK;KWIIIAVSVVLVAIIALIIGLSVGK;QALNEIESR 3 12.2 0.88803 -0.19967 0 0 0 0 0 0 5.79405 0 0 0 0 5.51472 P32926 DSG3_HUMAN Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) DSG3 CDHF6 Homo sapiens (Human) actin filament organization [GO:0007015]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; desmosome assembly [GO:0002159]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of p38MAPK cascade [GO:1903753]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of protein localization to adherens junction [GO:1904704]; positive regulation of protein localization to membrane [GO:1905477]; regulation of protein stability [GO:0031647]; tight junction assembly [GO:0120192] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; tight junction [GO:0070160] calcium ion binding [GO:0005509]; protein dimerization activity [GO:0046983] AEFHQSVISR;EVQPPSK;GQYDEEEMTMQQAK;IVSQEPAGTPMFLLSR;TITAEVLAIDEYTGK 5 6.2 0.95166 -0.6935 0 0 0 9.36416 0 0 0 0 0 6.35147 0 3.56961 P32927 IL3RB_HUMAN Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) CSF2RB IL3RB IL5RB Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to interleukin-3 [GO:0036016]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; immunoglobulin mediated immune response [GO:0016064]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023] DTATWKDSK;YEHIDHTFEIQYRKDTATWK 2 2.6 0.96441 -1.1784 0 0 0 0 0 0 0 0 0 0 0 10.2013 P32929 CGL_HUMAN Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) CTH Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process via cystathionine [GO:0019343]; cysteine metabolic process [GO:0006534]; endoplasmic reticulum unfolded protein response [GO:0030968]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homotetramerization [GO:0051289]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606] ISFVDCSK 1 2 0.91389 -0.39033 0 0 10.5616 0 0 0 0 0 0 0 0 0 P32942 ICAM3_HUMAN Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50) ICAM3 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; signaling receptor binding [GO:0005102] ATMVPSVLWPR;IDRATCPQHLK 2 4 0.91696 -0.42222 0 0 0 0 0 6.5345 0 9.93167 0 0 0 0 P32969 RL9_HUMAN Large ribosomal subunit protein uL6 (60S ribosomal protein L9) RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] FLDGIYVSEK;GVTLGFR;TICSHVQNMIK 3 14.6 0.027881 0.58626 0 0 0 0 0 0 8.89576 0 0 0 8.31302 0 P33076 C2TA_HUMAN MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) CIITA MHC2TA Homo sapiens (Human) immune response [GO:0006955]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to antibiotic [GO:0046677]; response to type II interferon [GO:0034341] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; acyltransferase activity [GO:0016746]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] LLRGCTLLLTARPRGR;YFESSGMTEHQDR 2 2.6 0.96559 -1.1241 0 0 0 4.23986 9.21502 0 0 0 0 0 0 0 P33121 ACSL1_HUMAN Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) ACSL1 FACL1 FACL2 LACS LACS1 LACS2 Homo sapiens (Human) adiponectin-activated signaling pathway [GO:0033211]; fatty acid transport [GO:0015908]; lipid biosynthetic process [GO:0008610]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; response to nutrient [GO:0007584]; response to oleic acid [GO:0034201]; response to organic cyclic compound [GO:0014070]; triglyceride biosynthetic process [GO:0019432]; very long-chain fatty acid metabolic process [GO:0000038]; xenobiotic catabolic process [GO:0042178] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; protein serine/threonine kinase activator activity [GO:0043539] AKRPELR;NIVSDCSAFVKATEK 2 3.2 0.95196 -0.70261 0 0 0 0 0 0 0 0 9.36571 0 0 0 P33151 CADH5_HUMAN Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) CDH5 Homo sapiens (Human) adherens junction organization [GO:0034332]; bicellular tight junction assembly [GO:0070830]; blood vessel endothelial cell migration [GO:0043534]; blood vessel maturation [GO:0001955]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; endothelial cell morphogenesis [GO:0001886]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to bicellular tight junction [GO:1902396]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein phosphorylation [GO:0001932]; regulation of vascular permeability [GO:0043114]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; fibrinogen binding [GO:0070051]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane transporter binding [GO:0044325]; vascular endothelial growth factor receptor 2 binding [GO:0043184] EVYPWYNLTVEAK 1 1.7 0.84785 -0.071639 0 0 0 0 0 0 0 0 0 10.0069 0 0 P33176 KINH_HUMAN Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) KIF5B KNS KNS1 Homo sapiens (Human) "anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; anterograde neuronal dense core vesicle transport [GO:1990048]; axon guidance [GO:0007411]; cellular response to type II interferon [GO:0071346]; centrosome localization [GO:0051642]; cytoplasm organization [GO:0007028]; lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]; mitochondrion transport along microtubule [GO:0047497]; mitocytosis [GO:0160040]; natural killer cell mediated cytotoxicity [GO:0042267]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of membrane potential [GO:0042391]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; retrograde neuronal dense core vesicle transport [GO:1990049]; stress granule disassembly [GO:0035617]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]" axon cytoplasm [GO:1904115]; centriolar satellite [GO:0034451]; ciliary rootlet [GO:0035253]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; postsynaptic cytosol [GO:0099524]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein-containing complex binding [GO:0044877] ALESALK;DNADLRCELPK;FVCSPDEVMDTIDEGKSNR;GGGAFVQNSQPVAVR;GGGGKQV;MMLEQERLRVEHEK;QLVRDNADLRCELPK;TGAEGAVLDEAK;VFQSSTSQEQVYNDCAK;YQQEVDR 10 11.7 0.90209 -0.26146 0 0 0 10.1584 8.99597 0 11.1009 0 7.644 11.6349 11.0654 9.72346 P33240 CSTF2_HUMAN Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) CSTF2 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; mRNA 3'-end processing [GO:0031124] cleavage body [GO:0071920]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] GLDARGLEAR;GPPLDGR;LVYDRETGKPK 3 4.9 0.97335 -2.6369 16.0965 16.4948 0 0 0 0 0 0 10.4418 0 0 0 P33402 GCYA2_HUMAN Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) GUCY1A2 GUC1A2 GUCSA2 Homo sapiens (Human) cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; response to oxygen levels [GO:0070482]; signal transduction [GO:0007165] "cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] EIPGICYFLEVR;KQLRCDTHK;TKPEASGSENK 3 4.4 0.97634 -2.1835 0 4.15178 0 0 0 0 0 0 0 6.34873 9.99421 0 P33527 MRP1_HUMAN Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; sphingolipid transporter activity [GO:0046624]; xenobiotic transmembrane transporter activity [GO:0042910] INESAEGEIIIDGINIAK;ITFWWITGLIVR;VVYSSKDPAQPKESSK 3 3 0.83547 -0.031037 0 0 0 0 0 0 8.51873 0 0 9.52101 5.39458 0 P33764 S10A3_HUMAN Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3) S100A3 S100E Homo sapiens (Human) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914] LCQAELK 1 6.9 0.92827 -0.47231 0 0 0 0 0 0 0 0 0 15.2042 15.2145 0 P33778 H2B1B_HUMAN Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) H2BC3 H2BFF HIST1H2BB Homo sapiens (Human) nucleosome assembly [GO:0006334] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AMGIMNSFVNDIFER;EIQTAVR;ESYSIYVYK;HAVSEGTK;IAGEASR;KESYSIYVYK;LAHYNKR;LLLPGELAK;PEPSKSAPAPK;QVHPDTGISSK 10 67.5 0.0088692 1.1325 12.3576 11.9739 0 0 0 0 0 0 0 0 0 9.28362 P33897 ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) ABCD1 ALD Homo sapiens (Human) alpha-linolenic acid metabolic process [GO:0036109]; fatty acid beta-oxidation [GO:0006635]; fatty acid elongation [GO:0030497]; fatty acid homeostasis [GO:0055089]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid catabolic process [GO:0042758]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisomal membrane transport [GO:0015919]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of mitochondrial depolarization [GO:0051900]; regulation of oxidative phosphorylation [GO:0002082]; sterol homeostasis [GO:0055092]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA catabolic process [GO:0036113] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; enzyme binding [GO:0019899]; fatty acyl-CoA hydrolase activity [GO:0047617]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817] PVLSRPRPWRGNTLKR 1 2.1 0.85066 -0.075545 0 0 0 0 0 9.69681 0 0 0 0 11.8955 0 P33908 MA1A1_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)" MAN1A1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein glycosylation [GO:0006486]; protein targeting to ER [GO:0045047] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" AVELGVK;KMYFDAVQAIETHLIR;MYFDAVQAIETHLIRK 3 3.7 0.22252 0.31609 11.3943 0 0 0 7.67447 0 9.09125 0 0 0 0 0 P33908 MA1A1_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)" MAN1A1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein glycosylation [GO:0006486]; protein targeting to ER [GO:0045047] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" AVELGVK;WMCNIPR 2 3.8 0.92967 -0.46569 0 0 0 0 11.4344 0 0 0 0 0 0 0 P33947 ERD22_HUMAN ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) KDELR2 ERD2.2 Homo sapiens (Human) "maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] LTGDLSHLAAIVILLLKIWK;NAEEKSQKVSV 2 16.7 0.87353 -0.10768 0 5.48961 8.28868 0 8.17268 0 0 0 7.29591 0 0 8.4071 P33981 TTK_HUMAN Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) TTK MPS1 MPS1L1 Homo sapiens (Human) chromosome segregation [GO:0007059]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; repair of mitotic kinetochore microtubule attachment defect [GO:0140273]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] ELTIDSIMNKVR;YSQAIEALPPDK 2 2.8 0.95205 -0.68513 0 10.859 0 0 0 0 10.0589 0 0 0 0 0 P33991 MCM4_HUMAN DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) MCM4 CDC21 Homo sapiens (Human) DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] ALADDDFLTVTGK;ATPAQTPR;ENFQRFLQR;GMVSAYPR;LAEAHAK;LSEEASQALIEAYVDMRK;SSPASTPSR;VEAIDVEEAK;VEGTPRSGVR;VEGTPRSGVRGTPVR;VNVTGIYR 11 12.2 0.95223 -0.7542 11.0743 0 0 0 0 9.88136 8.39343 12.5882 11.1984 11.3167 10.1379 10.9866 P33992 MCM5_HUMAN DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) MCM5 CDC46 Homo sapiens (Human) DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA replication origin binding [GO:0003688]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] AGITTTLNSR;CNTDQAGRPKCPLDPYFIMPDKCK;IAEALSK;LAALPNVYEVISK;RSSIPITVRQLEAIVR 5 9.5 0.012605 0.92494 0 0 0 0 0 0 10.9502 4.7731 0 8.48313 9.18926 10.2952 P33993 MCM7_HUMAN DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) MCM7 CDC47 MCM2 Homo sapiens (Human) cell population proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of phosphorylation [GO:0042325] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] DYALEKEK;ELVSGGR;FDLLWLIQDRPDRDNDLRLAQHITYVHQHSR;GSSGVGLTAAVLR;LMEMSKDSLLGDK;LVTVRGIVTRVSEVKPK;QFKYGNQLVRLAHR;SEDDESGAGELTR;SLEQNIQLPAALLSR;SPQNQYPAELMR;TQRPADVIFATVR 11 21.7 0 2.329 9.93466 10.6292 6.45301 7.75328 7.17143 0 6.99277 10.9893 12.2406 9.03496 9.79528 0 P34096 RNAS4_HUMAN Ribonuclease 4 (RNase 4) (EC 3.1.27.-) RNASE4 RNS4 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576]; extracellular space [GO:0005615] nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540] MNCHEGVVKVTDCR;VTDCRDTGSSRAPNCR 2 17 0.89693 -0.25138 0 0 9.38778 12.3975 0 0 9.98428 0 0 0 0 0 P34130 NTF4_HUMAN Neurotrophin-4 (NT-4) (Neurotrophin-5) (NT-5) (Neutrophic factor 4) NTF4 NTF5 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; ameloblast differentiation [GO:0036305]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; epidermis development [GO:0008544]; ganglion mother cell fate determination [GO:0007402]; innervation [GO:0060384]; long-term memory [GO:0007616]; mechanoreceptor differentiation [GO:0042490]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; neuron projection morphogenesis [GO:0048812]; sensory organ boundary specification [GO:0008052]; taste bud development [GO:0061193] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021] growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163] HWVSECK;SRRGVSETAPASR;VGWRWIRIDTACVCTLLSR 3 18.6 0.96886 -1.3309 7.21519 0 0 0 7.84361 0 15.0703 15.0376 15.1726 14.9426 15.1162 12.8314 P34741 SDC2_HUMAN Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) SDC2 HSPG1 Homo sapiens (Human) cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813]; regulation of dendrite morphogenesis [GO:0048814] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165] KMDPAEEDTNVYTEK;KPSSAAYQKAPTKEFYA 2 15.9 0.094801 0.37152 0 0 7.7086 0 0 9.32953 0 0 0 0 0 0 P34820 BMP8B_HUMAN Bone morphogenetic protein 8B (BMP-8) (BMP-8B) (Osteogenic protein 2) (OP-2) BMP8B BMP8 Homo sapiens (Human) cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503]; skeletal system development [GO:0001501] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] DSRLQMWKLR 1 2.9 0.30378 0.25018 0 0 7.5183 0 0 0 0 0 0 0 0 0 P34896 GLYC_HUMAN "Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT1 Homo sapiens (Human) carnitine biosynthetic process [GO:0045329]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to tetrahydrofolate [GO:1904482]; dTMP biosynthetic process [GO:0006231]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; negative regulation of translation [GO:0017148]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] aldehyde-lyase activity [GO:0016832]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; small molecule binding [GO:0036094] LGTPALTSR;NLEYARLR 2 3.5 0.8138 -0.00060839 0 0 0 0 4.24123 0 0 0 3.18656 0 10.7347 11.1287 P34897 GLYM_HUMAN "Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT2 Homo sapiens (Human) glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; positive regulation of cell population proliferation [GO:0008284]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial translation [GO:0070129]; regulation of oxidative phosphorylation [GO:0002082]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] amino acid binding [GO:0016597]; chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; L-allo-threonine aldolase activity [GO:0008732]; pyridoxal phosphate binding [GO:0030170] AFPMPGFDEH;AMADALLER;EYSLQVLK;GVKAVDPK;LGAPALTSR;LIDYARMR;LIIAGTSAYAR;TGLIDYNQLALTAR 8 15.3 0 6.2419 12.7758 13.6697 13.8822 8.59081 0 11.5581 0 0 10.5711 0 8.42673 0 P34910 EVI2B_HUMAN Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) EVI2B EVDB Homo sapiens (Human) myeloid cell development [GO:0061515]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of neutrophil differentiation [GO:0045660]; regulation of cell cycle [GO:0051726]; regulation of stem cell division [GO:2000035] plasma membrane [GO:0005886] NNYNSIAAILIGVLLTSMLVAIIIIVLWK;QLPSARTSTTQPPK 2 9.6 0.90761 -0.30608 0 0 0 0 6.49632 4.59962 0 0 0 0 0 0 P34913 HYES_HUMAN Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] EPHX2 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; dephosphorylation [GO:0016311]; epoxide metabolic process [GO:0097176]; phospholipid dephosphorylation [GO:0046839]; positive regulation of gene expression [GO:0010628]; regulation of cell growth [GO:0001558]; regulation of cholesterol metabolic process [GO:0090181]; response to toxic substance [GO:0009636]; stilbene catabolic process [GO:0046272] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity [GO:0033885]; epoxide hydrolase activity [GO:0004301]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643] CSETAKVCLPKNFSIK;GPLNWYRNMER;MEENCRKCSETAK;NMERNWK 4 7.6 0.97568 -2.3178 0 5.81191 0 0 0 6.20398 0 0 0 0 0 0 P34932 HSP74_HUMAN Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) HSPA4 APG2 HSPH2 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] AFSDPFVEAEK;AGGIETIANEYSDR;EFSITDVVPYPISLR;ELSTTLNADEAVTR;NTVQGFK;QSLTMDPVVK;VLATAFDTTLGGR;VTPQSDGSSSKVK 8 11.5 0 2.526 12.9426 12.2687 11.16 0 0 0 8.18115 8.40242 0 11.0725 9.31259 0 P34947 GRK5_HUMAN G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; tachykinin receptor signaling pathway [GO:0007217]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674] FPHISQCEDLR;FPHISQCEDLRR 2 2 0.91662 -0.41402 6.41549 0 0 0 0 10.9535 0 0 0 0 0 0 P34969 5HT7R_HUMAN 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7) HTR7 Homo sapiens (Human) "adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; blood circulation [GO:0008015]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589] SLLQCQYR 1 1.7 0.91571 -0.34779 12.6289 0 0 0 11.1865 9.83793 11.5751 0 0 0 0 0 P34972 CNR2_HUMAN Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) CNR2 CB2A CB2B Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; leukocyte chemotaxis [GO:0030595]; negative regulation of action potential [GO:0045759]; negative regulation of mast cell activation [GO:0033004]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; regulation of metabolic process [GO:0019222]; response to amphetamine [GO:0001975]; response to lipopolysaccharide [GO:0032496]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] cannabinoid receptor activity [GO:0004949] GLGSEAK;ITPWPDSRDLDLSDC 2 6.1 0.89754 -0.25426 0 11.6531 0 0 0 7.04636 10.0565 0 0 0 0 0 P34995 PE2R1_HUMAN Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) PTGER1 Homo sapiens (Human) adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]; response to prostaglandin E [GO:0034695] plasma membrane [GO:0005886] D1 dopamine receptor binding [GO:0031748]; prostaglandin E receptor activity [GO:0004957] QAVLRQLLRLLPPR;QLLRLLPPRAGAK;VSVARARLALAAVAAVALAVALLPLAR 3 11.2 0.039497 0.51729 6.70002 6.27318 0 0 0 0 0 0 0 5.63256 0 0 P34998 CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) CRHR1 CRFR CRFR1 CRHR Homo sapiens (Human) "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenal gland development [GO:0030325]; behavioral response to ethanol [GO:0048149]; cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; exploration behavior [GO:0035640]; fear response [GO:0042596]; female pregnancy [GO:0007565]; general adaptation syndrome, behavioral process [GO:0051867]; immune response [GO:0006955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; parturition [GO:0007567]; regulation of corticosterone secretion [GO:2000852]" endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone binding [GO:0051424]; corticotropin-releasing hormone receptor activity [GO:0043404]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930] LRASTTSETIQYRK 1 3.4 0.95981 -1.0502 0 0 0 0 0 0 0 0 0 0 10.2863 0 P35030 TRY3_HUMAN Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV) PRSS3 PRSS4 TRY3 TRY4 Homo sapiens (Human) antimicrobial humoral response [GO:0019730]; digestion [GO:0007586]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] extracellular region [GO:0005576]; extracellular space [GO:0005615]; tertiary granule lumen [GO:1904724] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GPAGEVAVPFDDDDK;IIRHPKYNR;LGEHNIK 3 12.9 0.95533 -0.88205 0 0 0 0 0 0 0 0 0 0 11.11 0 P35052 GPC1_HUMAN Glypican-1 [Cleaved into: Secreted glypican-1] GPC1 Homo sapiens (Human) cell migration [GO:0016477]; heparan sulfate proteoglycan catabolic process [GO:0030200]; myelin assembly [GO:0032288]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; regulation of protein localization to membrane [GO:1905475]; Schwann cell differentiation [GO:0014037] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; laminin binding [GO:0043236] VIQGCGNPKVNPQGPGPEEK;VNPQGPGPEEK 2 3.6 0.9158 -0.39439 0 7.66534 0 9.57788 0 0 0 0 7.66633 0 0 0 P35125 UBP6_HUMAN Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) USP6 HRP1 TRE2 Homo sapiens (Human) protein deubiquitination [GO:0016579]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of vesicle-mediated transport [GO:0060627] "cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; recycling endosome [GO:0055037]" calmodulin binding [GO:0005516]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; nucleic acid binding [GO:0003676] DGNSCAWCPQYRFCR;GPVWSVLLNIQEIK;LDGTTPVR;MADTSSTDEDSESDYEK;NQFFDTWAMNDDTVLK;RFQFVNDQWIK;TIAKYAPK;VQQKRLMK 8 6.9 0.97259 -2.7736 0 7.92452 0 8.61611 8.99331 0 0 0 0 0 7.66718 0 P35218 CAH5A_HUMAN "Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)" CA5A CA5 Homo sapiens (Human) one-carbon metabolic process [GO:0006730] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] NTWKTSAFSFLVEQMWAPLWSR 1 7.2 0.88347 -0.17325 0 0 0 0 0 0 0 10.4196 0 0 0 0 P35219 CAH8_HUMAN Carbonic anhydrase-related protein (CARP) (Carbonic anhydrase VIII) (CA-VIII) CA8 CALS Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; positive regulation of calcium-mediated signaling [GO:0050850] cytoplasm [GO:0005737] carbonate dehydratase activity [GO:0004089]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270] AVTEILQDIQYK 1 4.1 0.80655 0.012201 8.95411 8.04232 0 0 0 0 0 0 0 0 0 0 P35221 CTNA1_HUMAN Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) CTNNA1 Homo sapiens (Human) apical junction assembly [GO:0043297]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; epithelial cell-cell adhesion [GO:0090136]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; gap junction assembly [GO:0016264]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell motility [GO:2000146]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of protein localization to nucleus [GO:1900181]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; response to estrogen [GO:0043627]; smoothened signaling pathway [GO:0007224] acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; vinculin binding [GO:0017166] AAAGEFADDPCSSVK;IAEQVASFQEEK;LESIISGAALMADSSCTR;LLSNTVMPR;NAGNEQDLGIQYK;NLMNAVVQTVK;SDALNSAIDK 7 9.7 0.0046083 1.3052 9.59475 11.7775 10.834 0 0 0 0 9.16975 10.2325 0 0 0 P35222 CTNB1_HUMAN Catenin beta-1 (Beta-catenin) CTNNB1 CTNNB OK/SW-cl.35 PRO2286 Homo sapiens (Human) "acinar cell differentiation [GO:0090425]; adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; apoptotic signaling pathway [GO:0097190]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-matrix adhesion [GO:0007160]; cellular response to growth factor stimulus [GO:0071363]; cellular response to indole-3-methanol [GO:0071681]; central nervous system vasculogenesis [GO:0022009]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; cranial ganglion development [GO:0061550]; cranial skeletal system development [GO:1904888]; detection of muscle stretch [GO:0035995]; dorsal root ganglion development [GO:1990791]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal limb joint morphogenesis [GO:0036023]; endodermal cell fate commitment [GO:0001711]; endothelial tube morphogenesis [GO:0061154]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fungiform papilla formation [GO:0061198]; gastrulation with mouth forming second [GO:0001702]; genitalia morphogenesis [GO:0035112]; glial cell fate determination [GO:0007403]; hair cell differentiation [GO:0035315]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; hindbrain development [GO:0030902]; hypothalamus development [GO:0021854]; in utero embryonic development [GO:0001701]; layer formation in cerebral cortex [GO:0021819]; lens morphogenesis in camera-type eye [GO:0002089]; lung epithelial cell differentiation [GO:0060487]; lung induction [GO:0060492]; lung-associated mesenchyme development [GO:0060484]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal stem cell differentiation [GO:0072497]; metanephros morphogenesis [GO:0003338]; midbrain dopaminergic neuron differentiation [GO:1904948]; myoblast proliferation [GO:0051450]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule formation [GO:0072079]; neural plate development [GO:0001840]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron migration [GO:0001764]; neuron projection extension [GO:1990138]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; oocyte development [GO:0048599]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; outflow tract morphogenesis [GO:0003151]; oviduct development [GO:0060066]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to cell surface [GO:0034394]; protein polyubiquitination [GO:0000209]; proximal/distal pattern formation [GO:0009954]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion import [GO:0090279]; regulation of centriole-centriole cohesion [GO:0030997]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of fibroblast proliferation [GO:0048145]; regulation of myelination [GO:0031641]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neurogenesis [GO:0050767]; regulation of protein localization to cell surface [GO:2000008]; regulation of protein ubiquitination [GO:0031396]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of synapse assembly [GO:0051963]; regulation of T cell proliferation [GO:0042129]; regulation of timing of anagen [GO:0051884]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; renal vesicle formation [GO:0072033]; response to estradiol [GO:0032355]; response to xenobiotic stimulus [GO:0009410]; smooth muscle cell differentiation [GO:0051145]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; sympathetic ganglion development [GO:0061549]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle transport [GO:0048489]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]" "adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; Schaffer collateral - CA1 synapse [GO:0098685]; Scrib-APC-beta-catenin complex [GO:0034750]; spindle pole [GO:0000922]; synapse [GO:0045202]; transcription regulator complex [GO:0005667]; Wnt signalosome [GO:1990909]; Z disc [GO:0030018]" alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; I-SMAD binding [GO:0070411]; kinase binding [GO:0019900]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] AGDREDITEPAICALR;HQEAEMAQNAVRLHYGLPVVVK;KEASRHAIMR;LVQLLVRAHQDTQRR 4 8.1 0.97461 -3.4908 0 6.76394 0 0 0 0 12.2984 0 0 8.07286 0 0 P35226 BMI1_HUMAN Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) BMI1 PCGF4 RNF51 Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-1 [GO:0071347]; chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic skeletal system morphogenesis [GO:0048704]; hemopoiesis [GO:0030097]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of adaxial/abaxial pattern formation [GO:2000011]; regulation of gene expression [GO:0010468]; regulation of kidney development [GO:0090183]; rostrocaudal neural tube patterning [GO:0021903]; segment specification [GO:0007379]; somatic stem cell division [GO:0048103]" cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; ubiquitin ligase complex [GO:0000151] promoter-specific chromatin binding [GO:1990841]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin-protein transferase activator activity [GO:0097027]; zinc ion binding [GO:0008270] RYLRCPAAMTVMHLR 1 4.6 0.85115 -0.07926 0 0 0 0 0 0 0 0 0 0 0 8.23525 P35227 PCGF2_HUMAN Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) PCGF2 MEL18 RNF110 ZNF144 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; apoptotic signaling pathway [GO:0097190]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; embryonic skeletal system morphogenesis [GO:0048704]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] YLETNKYCPMCDVQVHK 1 4.9 0.95252 -0.67177 0 0 0 0 0 0 0 0 11.0119 0 0 0 P35228 NOS2_HUMAN "Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)" NOS2 NOS2A Homo sapiens (Human) arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; inflammatory response [GO:0006954]; innate immune response in mucosa [GO:0002227]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte mediated cytotoxicity [GO:0001912]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cellular respiration [GO:0043457]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to bacterium [GO:0009617]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801] cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617] LVQDSQPLDLSK;QAWRNAPR;QHIQIPKLYTSNVTWDPHHYR;SRQNLQSPTSSR 4 4.6 0.9631 -1.0853 0 0 0 9.46099 9.73562 0 0 9.03837 0 0 0 0 P35232 PHB1_HUMAN Prohibitin 1 PHB1 PHB Homo sapiens (Human) antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; cellular response to interleukin-6 [GO:0071354]; DNA biosynthetic process [GO:0071897]; epigenetic regulation of gene expression [GO:0040029]; mitochondrion organization [GO:0007005]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; progesterone receptor signaling pathway [GO:0050847]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; RIG-I signaling pathway [GO:0039529]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; T-helper 17 type immune response [GO:0072538] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] complement component C3a binding [GO:0001850]; complement component C3b binding [GO:0001851]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; proteinase activated receptor binding [GO:0031871]; transcription corepressor activity [GO:0003714] AAIISAEGDSK;DLQNVNITLR;FDAGELITQR;NITYLPAGQSVLLQLPQ;NVPVITGSK;QVAQQEAER;QVSDDLTER;VFESIGK;VLPSITTEILK 9 34.2 0 6.4244 12.7892 11.8877 12.7655 8.93 8.85907 8.60481 9.38083 0 12.1313 11.4163 11.9707 0 P35236 PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) PTPN7 Homo sapiens (Human) MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" QAREQQRR;QLEEEFLK;QPPSPKQLEEEFLK 3 5.5 0.97629 -1.478 0 0 0 0 0 0 0 0 0 11.5058 0 0 P35236 PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) PTPN7 Homo sapiens (Human) MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" KLASWSLLSPQRQTDR;MQLGCAWVAAR;QLEEEFLK;QPPSPKQLEEEFLK 4 8.8 0.97622 -2.2974 0 0 0 0 0 0 0 10.2878 0 14.8615 0 0 P35237 SPB6_HUMAN Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) SERPINB6 PI6 PTI Homo sapiens (Human) cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; sensory perception of sound [GO:0007605] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821] protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] NLGMTDAFELGK;TGTQYLLR 2 5.3 0.95508 -0.94666 0 0 5.93581 0 0 0 0 8.18418 0 11.111 0 0 P35240 MERL_HUMAN Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) NF2 SCH Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; MAPK cascade [GO:0000165]; mesoderm formation [GO:0001707]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of Schwann cell proliferation [GO:0010626]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast proliferation [GO:0033687]; positive regulation of cell differentiation [GO:0045597]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of organelle assembly [GO:1902115]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; integrin binding [GO:0005178] AGAIASRMSFSSLK;ISFPWNEIR;LILQLCIGNHDLFMR;LSMEIEK 4 7.6 0.97236 -2.7838 10.7712 12.8846 0 10.0792 10.3319 0 10.1739 9.85957 10.5217 10.2477 10.0452 10.5417 P35241 RADI_HUMAN Radixin RDX Homo sapiens (Human) apical protein localization [GO:0045176]; barbed-end actin filament capping [GO:0051016]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cell tip [GO:0051286]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; stereocilium base [GO:0120044]; T-tubule [GO:0030315] actin binding [GO:0003779]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723] APDFVFYAPR;EELMERLKQIEEQTIK;ENPLQFK;FVIKPIDK;IGFPWSEIR;KENPLQFK;KPDTIEVQQMK;NISFNDKK;QLFDQVVK;RKPDTIEVQQMK;TVGLREVWFFGLQYVDSK;VTQQDVK;VTTMDAELEFAIQPNTTGK 13 21.1 0.98026 -1.6692 0 9.30973 9.48828 0 6.84624 0 0 0 0 0 0 0 P35243 RECO_HUMAN Recoverin (Cancer-associated retinopathy protein) (Protein CAR) RCVRN RCV1 Homo sapiens (Human) phototransduction [GO:0007602]; regulation of calcium ion transport [GO:0051924]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]; visual perception [GO:0007601] dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048] LEWAFSLYDVDGNGTISK 1 9 0.78352 0.022981 0 3.09689 0 0 3.9715 0 0 0 0 0 7.77676 0 P35247 SFTPD_HUMAN Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) SFTPD COLEC7 PSPD SFTP4 Homo sapiens (Human) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; lung alveolus development [GO:0048286]; macrophage chemotaxis [GO:0048246]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of phagocytosis [GO:0050766]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; regulation of cytokine production [GO:0001817]; respiratory gaseous exchange by respiratory system [GO:0007585]; surfactant homeostasis [GO:0043129] clathrin-coated endocytic vesicle [GO:0045334]; collagen trimer [GO:0005581]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body [GO:0005771] carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802] GLAGPKGERGVPGER 1 4 0.96549 -1.2135 0 0 0 0 0 0 0 0 0 0 12.6758 0 P35249 RFC4_HUMAN Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) RFC4 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] FCLICNYVSRIIEPLTSR;GVAASAGSSGENKKAKPVPWVEK;IQQQRLLDIAK;LTGGKEITEK 4 17.1 0.97404 -2.4187 0 0 0 12.5492 12.4143 6.7654 0 0 0 0 0 13.5015 P35250 RFC2_HUMAN Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) RFC2 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899] APGSAGHYELPWVEK;FALACNASDKIIEPIQSR 2 9.3 0.95273 -0.76132 0 13.3302 0 11.1113 11.728 11.0698 0 11.7252 0 0 9.56289 0 P35251 RFC1_HUMAN Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) RFC1 RFC140 Homo sapiens (Human) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; telomere maintenance via telomerase [GO:0007004] DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA clamp unloader activity [GO:0061860]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565] HAAKFGK;KHAAKFGK;TLAMLDEEPKTKK;VTGNVSK 4 2.4 0.98206 -1.5862 13.5578 13.9428 13.9044 11.5348 0 10.7553 11.9051 0 11.1604 0 0 0 P35268 RL22_HUMAN Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) RPL22 Homo sapiens (Human) alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translation at presynapse [GO:0140236] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; presynapse [GO:0098793]; ribonucleoprotein complex [GO:1990904] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AGNLGGGVVTIER;ITVTSEVPFSK;LVVKGGK 3 24.2 0 3.8087 12.458 11.3636 13.1548 0 0 0 10.7611 10.4313 10.4841 0 11.3065 0 P35269 T2FA_HUMAN General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) GTF2F1 RAP74 Homo sapiens (Human) negative regulation of protein binding [GO:0032091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; response to virus [GO:0009615]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIF complex [GO:0005674] DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TFIIF-class transcription factor complex binding [GO:0001096] AALGPSSQNVTEYVVR;EFRPEDQPWLLRVNGK;VNFATWNQARLERDLSNK 3 9.7 0 4.1445 0 0 7.52763 0 0 0 0 0 11.2435 0 0 0 P35270 SPRE_HUMAN Sepiapterin reductase (SPR) (EC 1.1.1.153) SPR Homo sapiens (Human) nitric oxide biosynthetic process [GO:0006809]; tetrahydrobiopterin biosynthetic process [GO:0006729] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aldo-keto reductase (NADPH) activity [GO:0004033]; NADP binding [GO:0050661]; sepiapterin reductase (NADP+) activity [GO:0004757] AFPDSPGLNR;AVCLLTGASR;ELPRPKGLQR 3 11.5 0.95596 -0.8402 0 0 0 0 0 0 0 0 8.69255 0 10.0787 11.4575 P35318 ADML_HUMAN Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] ADM AM Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; androgen metabolic process [GO:0008209]; animal organ regeneration [GO:0031100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cAMP-mediated signaling [GO:0019933]; cell population proliferation [GO:0008283]; developmental growth [GO:0048589]; female pregnancy [GO:0007565]; G protein-coupled receptor internalization [GO:0002031]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular permeability [GO:0043116]; negative regulation of vasoconstriction [GO:0045906]; neural tube closure [GO:0001843]; neuron projection regeneration [GO:0031102]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of progesterone biosynthetic process [GO:2000184]; positive regulation of vasculogenesis [GO:2001214]; receptor internalization [GO:0031623]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of the force of heart contraction [GO:0002026]; regulation of urine volume [GO:0035809]; response to ether [GO:0045472]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; signal transduction [GO:0007165]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] ISPQGYGR;YRQSMNNFQGLR 2 10.8 0.96354 -1.1074 10.0337 0 0 0 0 0 0 10.2876 0 0 0 0 P35348 ADA1A_HUMAN Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) ADRA1A ADRA1C Homo sapiens (Human) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of action potential [GO:0045760]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; response to hormone [GO:0009725]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]" caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982] DQSSCTTARVR 1 2.4 0.88247 -0.17994 0 0 0 7.85281 0 0 0 0 0 0 0 0 P35348 ADA1A_HUMAN Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) ADRA1A ADRA1C Homo sapiens (Human) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of action potential [GO:0045760]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; response to hormone [GO:0009725]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]" caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982] LECSGMILAHCNLR 1 2.9 0.78315 0.020018 0 0 0 0 4.32675 0 0 0 0 0 0 0 P35354 PGH2_HUMAN Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 Homo sapiens (Human) "angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; brown fat cell differentiation [GO:0050873]; cellular response to ATP [GO:0071318]; cellular response to fluid shear stress [GO:0071498]; cellular response to heat [GO:0034605]; cellular response to homocysteine [GO:1905375]; cellular response to hypoxia [GO:0071456]; cellular response to lead ion [GO:0071284]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to non-ionic osmotic stress [GO:0071471]; cyclooxygenase pathway [GO:0019371]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; hair cycle [GO:0042633]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of smooth muscle contraction [GO:0045986]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; positive regulation of apoptotic process [GO:0043065]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fever generation [GO:0031622]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin secretion [GO:0032310]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of neuroinflammatory response [GO:0150077]; response to angiotensin [GO:1990776]; response to estradiol [GO:0032355]; response to fatty acid [GO:0070542]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to manganese ion [GO:0010042]; response to nematode [GO:0009624]; response to oxidative stress [GO:0006979]; response to selenium ion [GO:0010269]; response to tumor necrosis factor [GO:0034612]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]" caveola [GO:0005901]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; protein-containing complex [GO:0032991] "enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; protein homodimerization activity [GO:0042803]" IVIEDYVQHLSGYHFKLK 1 3 0.81067 -0.014661 0 0 0 0 9.3206 0 0 0 0 0 0 0 P35367 HRH1_HUMAN Histamine H1 receptor (H1-R) (H1R) (HH1R) HRH1 Homo sapiens (Human) "cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; memory [GO:0007613]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; regulation of vascular permeability [GO:0043114]; visual learning [GO:0008542]" cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] histamine receptor activity [GO:0004969] AVRQHCQHR;YLKYRTK 2 3.3 0.9047 -0.26989 0 0 0 0 0 0 0 0 0 0 0 8.42068 P35368 ADA1B_HUMAN Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B Homo sapiens (Human) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229] caveola [GO:0005901]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982] KAILALLSVWVLSTVISIGPLLGWK;YSLQYPTLVTRRK 2 7.1 0.71792 0.13555 7.43279 0 0 0 0 0 0 0 0 0 7.43204 0 P35372 OPRM_HUMAN Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) OPRM1 MOR1 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; behavioral response to ethanol [GO:0048149]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of Wnt protein secretion [GO:0061358]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of cellular response to stress [GO:0080135]; regulation of NMDA receptor activity [GO:2000310]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]" axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202] beta-endorphin receptor activity [GO:0004979]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923]; voltage-gated calcium channel activity [GO:0005245] KGQESSKDHQDGAGGGGCVHR 1 11.3 0.86411 -0.083824 0 0 0 0 0 0 0 0 0 7.32346 0 0 P35398 RORA_HUMAN Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) RORA NR1F1 RZRA Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; intracellular receptor signaling pathway [GO:0030522]; muscle cell differentiation [GO:0042692]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" MNEGAPGDSDLETEAR;NRCQHCRLQK 2 4.7 0.78448 0.029028 0 0 0 0 0 0 0 0 0 0 0 9.94929 P35410 MAS1L_HUMAN Mas-related G-protein coupled receptor MRG (MAS-R) (MAS1-like) MAS1L MRG Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] angiotensin receptor activity [GO:0001595]; G protein-coupled receptor activity [GO:0004930] ICWFSQR;SLFLTYWKHVKACVIFLK 2 6.6 0.9189 -0.43659 0 0 0 0 0 0 9.24821 0 0 0 11.8948 0 P35414 APJ_HUMAN Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) APLNR AGTRL1 APJ Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adult heart development [GO:0007512]; angiogenesis [GO:0001525]; aorta development [GO:0035904]; apelin receptor signaling pathway [GO:0060183]; atrioventricular valve development [GO:0003171]; blood vessel development [GO:0001568]; coronary vasculature development [GO:0060976]; endocardial cushion formation [GO:0003272]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation [GO:0007369]; heart development [GO:0007507]; heart looping [GO:0001947]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of body fluid levels [GO:0050878]; regulation of gap junction assembly [GO:1903596]; regulation of gene expression [GO:0010468]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412] plasma membrane [GO:0005886] apelin receptor activity [GO:0060182]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023] MEEGGDFDNYYGADNQSECEYTDWK 1 6.6 0.71344 0.15167 0 0 0 0 0 0 0 0 0 0 5.21432 0 P35442 TSP2_HUMAN Thrombospondin-2 THBS2 TSP2 Homo sapiens (Human) cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] ACSLSKCDTR;DGQGDACDPDDDNDGVPDDR;EGFFLTAQLK;EGFFLTAQLKQDGK;LCNSPVPQMGGK;MYVAKGSAR;WHLTHRPK 7 6.2 0.97814 -2.1315 0 0 5.47962 0 9.62428 4.67553 0 0 0 11.5316 11.1879 0 P35443 TSP4_HUMAN Thrombospondin-4 THBS4 TSP4 Homo sapiens (Human) behavioral response to pain [GO:0048266]; endothelial cell-cell adhesion [GO:0071603]; myoblast migration [GO:0051451]; negative regulation of angiogenesis [GO:0016525]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of tissue remodeling [GO:0034103]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; tissue remodeling [GO:0048771] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasmic reticulum [GO:0016529] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178] DTDGDGRGDACDDDMDGDGIK;GDACDDDMDGDGIK;LAPRGAAVLLLHLVLQR;LLWKDSRNVGWK 4 5.2 0.98001 -1.5696 3.43803 0 4.12623 3.9581 6.85587 7.0735 0 0 0 0 0 9.31059 P35453 HXD13_HUMAN Homeobox protein Hox-D13 (Homeobox protein Hox-4I) HOXD13 HOX4I Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; branch elongation of an epithelium [GO:0060602]; embryonic digit morphogenesis [GO:0042733]; embryonic hindgut morphogenesis [GO:0048619]; male genitalia development [GO:0030539]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VPYTKLQLK 1 2.6 0.90398 -0.26778 0 0 0 0 0 0 0 0 8.64796 0 0 0 P35462 DRD3_HUMAN D(3) dopamine receptor (Dopamine D3 receptor) DRD3 Homo sapiens (Human) "acid secretion [GO:0046717]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; arachidonate secretion [GO:0050482]; behavioral response to cocaine [GO:0048148]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of blood pressure [GO:0045776]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; prepulse inhibition [GO:0060134]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of potassium ion transport [GO:0043266]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; visual learning [GO:0008542]" plasma membrane [GO:0005886]; synapse [GO:0045202] "dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]" NSLSPTIAPKLSLEVR 1 4 0.81239 -0.013739 0 0 0 0 0 0 0 0 8.76865 0 0 0 P35475 IDUA_HUMAN Alpha-L-iduronidase (EC 3.2.1.76) IDUA Homo sapiens (Human) dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin catabolic process [GO:0030211] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202] L-iduronidase activity [GO:0003940]; signaling receptor binding [GO:0005102] LTLRPALR 1 1.2 0.93397 -0.4969 10.7596 0 0 0 0 0 0 0 0 0 0 0 P35498 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) SCN1A NAC1 SCN1 Homo sapiens (Human) adult walking behavior [GO:0007628]; cardiac muscle cell action potential involved in contraction [GO:0086002]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; membrane depolarization during action potential [GO:0086010]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuronal action potential propagation [GO:0019227]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] axon initial segment [GO:0043194]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018] voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248] KIYEFIQQSFIR;TISVIPGLKTIVGALIQSVK;TLRALRPLRALSR;VLRALKTISVIPGLK 4 2.5 0.34889 0.23617 0 0 0 0 0 0 7.80252 0 0 0 0 0 P35499 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) SCN4A Homo sapiens (Human) cardiac muscle cell action potential involved in contraction [GO:0086002]; muscle contraction [GO:0006936]; regulation of skeletal muscle contraction by action potential [GO:0100001]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] ALKTITVIPGLKTIVGALIQSVK;HSHDGSGDDAPEK;TITVIPGLKTIVGALIQSVKK;TLRALRPLRALSR;VLIWNCCAPWLK 5 3.4 0.92876 -0.46403 0 0 0 0 0 5.57921 8.13515 0 0 4.20445 0 0 P35503 UD13_HUMAN UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3) UGT1A3 GNT1 UGT1 Homo sapiens (Human) bile acid secretion [GO:0032782]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; flavonoid glucuronidation [GO:0052696]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; retinoic acid metabolic process [GO:0042573]; vitamin D3 metabolic process [GO:0070640]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972] AMAIADALGK;EVSVVDILSHASVWLFR;IPQTVLWR 3 6.6 0.78387 0.026648 0 0 0 0 0 0 0 8.7186 0 0 0 0 P35504 UD15_HUMAN UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E) UGT1A5 GNT1 UGT1 Homo sapiens (Human) cellular glucuronidation [GO:0052695] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AMAIADALGK;GHQVVVLTLEVNMYIK;IPQTVLWR 3 6.4 0.78311 0.026296 0 0 10.756 0 0 0 0 0 0 0 0 0 P35520 CBS_HUMAN Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) CBS Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; DNA protection [GO:0042262]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine catabolic process [GO:0019448]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] carbon monoxide binding [GO:0070025]; cystathionine beta-synthase activity [GO:0004122]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; nitric oxide binding [GO:0070026]; nitrite reductase (NO-forming) activity [GO:0050421]; oxygen binding [GO:0019825]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; S-adenosyl-L-methionine binding [GO:1904047]; ubiquitin protein ligase binding [GO:0031625] FLSDRWMLQKGFLK;KPWWWHLR;LTDTLGR;VIYKQFK 4 6.5 0.96564 -1.2569 0 12.4487 0 0 8.15866 0 0 0 0 6.29124 0 9.67492 P35527 K1C9_HUMAN "Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)" KRT9 Homo sapiens (Human) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] EIETYHNLLEGGQEDFESSGAGK;FSSSGGGGGGGR;FSSSGGGGGGGRFSSSSGYGGGSSR;FSSSSGYGGGSSR;GGGGSFGYSYGGGSGGGFSASSLGGGFGGGSR;GGSGGSYGGGGSGGGYGGGSGSR;GGSGGSYGR;LASYLDK;MTLDDFR;QEYEQLIAK;QEYEQLIAKNRK;QGVDADINGLR;QVLDNLTMEK;SGGGGGGGLGSGGSIR;STMQELNSR;TLLDIDNTR 16 31 0 138.16 13.0231 12.866 10.5347 12.6834 12.6879 12.9009 14.1428 13.9166 14.1941 14.9635 15.0749 10.4332 P35555 FBN1_HUMAN Fibrillin-1 [Cleaved into: Asprosin] FBN1 FBN Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; gene expression [GO:0010467]; heart development [GO:0007507]; lung alveolus development [GO:0048286]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877] CDEGYESGFMMMK;CMNGGSCSDDHCLCQK;DEDECEEGKHDCTEK;DEDECEEGKHDCTEKQMECK;RMCKDEDECEEGK;TCEDIDECESSPCINGVCK;TCVDVNECDLNPNICLSGTCENTK;TNDDQTMCLDINECERDACGNGTCR 8 4.2 0.97164 -1.3515 0 0 0 8.10271 0 0 0 7.69697 9.40342 5.54009 0 6.38198 P35556 FBN2_HUMAN Fibrillin-2 [Cleaved into: Placensin] FBN2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; hormone activity [GO:0005179] CAQELPGRMTKMQCCCEPGR;CECNEGFQSSSSGTECLDNR;CECNMGYK;CECPTGFSYNDLLLVCEDIDECSNGDNLCQR;CICPPGYEVK;CMNGGTCADDHCQCQK;CVNIIGSYRCECNEGFQSSSSGTECLDNR;DLDECAEGLHDCESR;EDQKMCKDLDECAEGLHDCESR;NCMDIDECERNPLLCR;TLCCATIGR 11 5.5 0.97489 -3.7028 11.1955 0 0 0 0 6.32772 11.1859 11.7269 8.69683 8.48792 9.24631 0 P35557 HXK4_HUMAN Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) GCK Homo sapiens (Human) calcium ion import [GO:0070509]; canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; glucose 6-phosphate metabolic process [GO:0051156]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; NADP metabolic process [GO:0006739]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; regulation of glycolytic process [GO:0006110]; regulation of insulin secretion [GO:0050796]; regulation of potassium ion transport [GO:0043266]; response to glucose [GO:0009749] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose sensor activity [GO:0141089]; mannokinase activity [GO:0019158] FVSQVESDTGDRK;ITVGVDGSVYK 2 5.2 0.95554 -0.93299 0 0 0 0 0 0 0 0 0 0 9.51556 0 P35558 PCKGC_HUMAN "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)" PCK1 PEPCK1 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to potassium ion starvation [GO:0051365]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; oxaloacetate metabolic process [GO:0006107]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propionate catabolic process [GO:0019543]; regulation of lipid biosynthetic process [GO:0046890]; response to bacterium [GO:0009617]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; tricarboxylic acid metabolic process [GO:0072350] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062] carboxylic acid binding [GO:0031406]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264] EFWEKEVEDIEK;IFHVNWFRKDK;YDNCWLALTDPR 3 5.6 0.96555 -1.2449 0 0 6.14274 0 9.4384 7.4219 0 0 0 0 0 0 P35568 IRS1_HUMAN Insulin receptor substrate 1 (IRS-1) IRS1 Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to insulin [GO:0032868]; signal transduction [GO:0007165] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphotyrosine residue binding [GO:0001784]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LSLGDPK;VNLSPNR 2 1.1 0.91428 -0.33711 0 0 0 0 0 0 0 0 0 10.0606 0 0 P35573 GDE_HUMAN "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" AGL GDE Homo sapiens (Human) glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; inclusion body [GO:0016234]; isoamylase complex [GO:0043033]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; secretory granule lumen [GO:0034774] "4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]; glycogen debranching enzyme activity [GO:0004133]; polysaccharide binding [GO:0030247]; polyubiquitin modification-dependent protein binding [GO:0031593]" AVTVYTNYPFPGETFNREK;IEEVVLEARTIER;LGPVTRKHPLVTR;LMGPETTAK;NDLGHPFCNNLRSGDWMIDYVSNR;NIFPYHEVTVKRHGK;NTKPYRKDENSINGTPDITVEIR 7 7.6 0.97738 -2.1708 0 0 0 3.90516 0 10.5514 12.088 0 0 0 4.77041 0 P35575 G6PC1_HUMAN Glucose-6-phosphatase catalytic subunit 1 (EC 3.1.3.9) (Glucose-6-phosphatase) (G-6-Pase) (G6Pase) (Glucose-6-phosphatase alpha) (G6Pase-alpha) G6PC1 G6PC G6PT Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glucose-6-phosphate transport [GO:0015760]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; multicellular organism growth [GO:0035264]; regulation of gene expression [GO:0010468]; steroid metabolic process [GO:0008202]; triglyceride metabolic process [GO:0006641]; urate metabolic process [GO:0046415] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "glucose-6-phosphatase activity [GO:0004346]; phosphate ion binding [GO:0042301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" IKPTYRFRCLNVILWLGFWAVQLNVCLSR 1 8.1 0.87341 -0.11366 7.9978 0 0 0 0 0 0 0 0 0 0 0 P35579 MYH9_HUMAN "Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)" MYH9 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cortical granule exocytosis [GO:0060471]; cytokinetic process [GO:0032506]; endodermal cell differentiation [GO:0035987]; establishment of meiotic spindle localization [GO:0051295]; establishment of T cell polarity [GO:0001768]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lysosome localization [GO:0032418]; meiotic spindle organization [GO:0000212]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte differentiation [GO:0030224]; myoblast fusion [GO:0007520]; negative regulation of actin filament severing [GO:1903919]; phagocytosis, engulfment [GO:0006911]; plasma membrane repair [GO:0001778]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]; regulation of cell shape [GO:0008360]; regulation of plasma membrane repair [GO:1905684]; symbiont entry into host cell [GO:0046718]; uropod organization [GO:0032796]" actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; actomyosin contractile ring [GO:0005826]; adherens junction [GO:0005912]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; spindle [GO:0005819]; stress fiber [GO:0001725]; uropod [GO:0001931] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618] AEAEAREK;AGVLAHLEEERDLK;ALEEAMEQK;ALELDSNLYR;ALEQQVEEMK;ANLQIDQINTDLNLER;ASITALEAK;DELADEIANSSGK;DFSALESQLQDTQELLQEENR;DQGELER;EEELVKVR;EEILAQAK;ELEDATETADAMNR;EQEVNILK;EQLEEEEEAK;FDQLLAEEK;FVSELWKDVDR;GDLPFVVPR;GELANEVK;IAEFTTNLTEEEEK;IAQLEEELEEEQGNTELINDR;IAQLEEQLDNETK;ICRQGFPNR;IMGIPEEEQMGLLR;KFDQLLAEEK;KQELEEICHDLEAR;LEVNLQAMK;LQEMEGTVK;LQLEKVTTEAK;LQVELDNVTGLLSQSDSK;LVWVPSDK;NLPIYSEEIVEMYK;NTDQASMPDNTAAQK;NTNPNFVR;QIATLHAQVADMK;QLAAENR;QLEEAEEEAQR;QLLQANPILEAFGNAK;QQQLTAMK;QRYEILTPNSIPK;QTLENER;QTLENERGELANEVK;SMAVAAR;SMEAEMIQLQEELAAAER;TDLLLEPYNK;TLEEEAK;TVGQLYKEQLAK;TVKNDNSSR;VEAQLQELQVK;VEEEAAQK;VEEEEER;VIQYLAYVASSHKSKK;VMQEQGTHPK;VNKDDIQK;VNKDDIQKMNPPK;VVFQEFR;YEILTPNSIPK 57 30.1 0 111.95 13.864 14.3724 14.5403 11.074 11.2477 6.76022 12.8565 13.5902 14.216 14.6744 14.4642 14.2946 P35580 MYH10_HUMAN "Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)" MYH10 Homo sapiens (Human) actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; cell adhesion [GO:0007155]; mitotic cytokinesis [GO:0000281]; positive regulation of protein secretion [GO:0050714]; regulation of cell shape [GO:0008360]; symbiont entry into host cell [GO:0046718] actomyosin [GO:0042641]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; midbody [GO:0030496]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; nucleus [GO:0005634]; postsynaptic actin cytoskeleton [GO:0098871]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; mRNA 5'-UTR binding [GO:0048027]; RNA stem-loop binding [GO:0035613]; virus receptor activity [GO:0001618] AEAEAREK;AGVLAHLEEERDLK;ALSLARALEEALEAKEEFER;AVIYNPATQADWTAK;DYQRELEEARASR;EIFMQVEDER;ELACEVKVLQQVK;FDQLLAEEK;ICRQGFPNR;KFDQLLAEEK;LEEKALAYDK;NLPIYSENIIEMYRGK;NTNPNFVR;QVRELEAELEDERK;TVGQLYKESLTK;TVKNDNSSR;VEEEEER;VKPLLQVTRQEEELQAK 18 10.4 0.97523 -3.446 11.0558 0 13.0294 11.4809 6.63391 9.11346 0 11.5503 12.8636 11.4285 9.80565 0 P35590 TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; branching involved in lymph vessel morphogenesis [GO:0060854]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; in utero embryonic development [GO:0001701]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; positive regulation of angiogenesis [GO:0045766]; regulation of endothelial cell proliferation [GO:0001936]; regulation of extracellular matrix assembly [GO:1901201]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; tissue remodeling [GO:0048771]; vasculogenesis [GO:0001570] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LWDGTRGQERR;MEQPRNCDDEVYELMR 2 2.4 0.86656 -0.092604 0 0 7.20291 0 0 0 0 6.86282 6.58876 6.24578 5.68944 0 P35606 COPB2_HUMAN Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) COPB2 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] AMGDAEIK;DNNQFASASLDR;IIWAKHSEVQQANLK;LPEAAFLAR;SFGSAQEFAWAHDSSEYAIR;TYLPSQVSR;VFNYNTLER 7 9.1 0.9802 -1.6547 0 10.6088 9.8024 9.29845 0 0 10.602 9.00011 4.23818 0 0 13.161 P35609 ACTN2_HUMAN Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) ACTN2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament uncapping [GO:0051695]; cardiac muscle cell development [GO:0055013]; cell adhesion [GO:0007155]; focal adhesion assembly [GO:0048041]; microspike assembly [GO:0030035]; muscle cell development [GO:0055001]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of protein localization to cell surface [GO:2000009]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; positive regulation of cation channel activity [GO:2001259]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to plasma membrane [GO:0072659]; regulation of apoptotic process [GO:0042981]; regulation of membrane potential [GO:0042391]; sarcomere organization [GO:0045214] "actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; pseudopodium [GO:0031143]; Z disc [GO:0030018]" "actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cytoskeletal protein binding [GO:0008092]; FATZ binding [GO:0051373]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; nuclear receptor coactivator activity [GO:0030374]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; structural constituent of muscle [GO:0008307]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]" DLLLDPAWEK;FAIQDISVEETSAK;MVSDIAGAWQR;NGLMDHEDFRACLISMGYDLGEAEFAR;TFTAWCNSHLRK;TIPWLENRTPEK;TIPWLENRTPEKTMQAMQK 7 10.4 0.95686 -1.023 0 6.32645 0 0 0 0 12.3732 11.3421 11.5305 0 0 11.4489 P35610 SOAT1_HUMAN Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; sterol O-acyltransferase activity [GO:0004772] NIKQEPFSAR;SRENPEEDEDQRNPAK;VGEEKMSLR 3 6.4 0.97421 -2.4363 0 0 0 0 0 0 11.0645 0 0 7.91534 0 0 P35611 ADDA_HUMAN Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 ADDA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; cellular response to calcium ion [GO:0071277]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of protein binding [GO:0032092] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; spectrin binding [GO:0030507] CVVHIHTPAGAAVSAMK;GDEASEEGQNGSSPK;MLDNLGYRTGYPYRYPALR;NKIREQNLQDIK 4 8.5 0.96679 -1.2925 0 11.7965 11.8507 0 0 0 0 7.67969 11.8188 0 0 8.81714 P35612 ADDB_HUMAN Beta-adducin (Erythrocyte adducin subunit beta) ADD2 ADDB Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; positive regulation of protein binding [GO:0032092]; protein-containing complex assembly [GO:0065003]; synapse assembly [GO:0007416] cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] HPFVQEKTKHK;LLDLYGWAQLSDTYVTLR 2 4 0.96557 -1.2579 0 0 2.87965 0 0 8.57194 0 0 8.43413 0 0 0 P35613 BASI_HUMAN Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) BSG UNQ6505/PRO21383 Homo sapiens (Human) angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial tube morphogenesis [GO:0061154]; neural retina development [GO:0003407]; neutrophil chemotaxis [GO:0030593]; odontogenesis of dentin-containing tooth [GO:0042475]; photoreceptor cell maintenance [GO:0045494]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of viral entry into host cell [GO:0046598]; protein localization to plasma membrane [GO:0072659]; response to cAMP [GO:0051591]; response to mercury ion [GO:0046689]; response to peptide hormone [GO:0043434] acrosomal membrane [GO:0002080]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] cadherin binding [GO:0045296]; D-mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] FFVSSSQGR;KPEDVLDDDDAGSAPLK;SESVPPVTDWAWYK 3 10.4 0.015595 0.76404 0 10.319 0 0 0 0 11.3314 0 0 9.33666 9.87773 0 P35625 TIMP3_HUMAN Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Homo sapiens (Human) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metalloendopeptidase activity [GO:1904684]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet dense granule lumen [GO:0031089] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191] KLVKEGPFGTLVYTIK 1 7.6 0.43851 0.1946 0 0 0 0 0 6.93428 0 0 0 0 0 0 P35626 ARBK2_HUMAN G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2) GRK3 ADRBK2 BARK2 Homo sapiens (Human) desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled receptor signaling pathway [GO:0007186]; receptor internalization [GO:0031623]; signal transduction [GO:0007165] cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672] KADTGKMYAMK;LGNPFLTQWQRR;NEITFDKIFNQK 3 5.1 0.82344 -0.018015 0 0 0 0 0 10.2206 8.10339 0 0 0 0 0 P35637 FUS_HUMAN RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) FUS TLS Homo sapiens (Human) amyloid fibril formation [GO:1990000]; mRNA stabilization [GO:0048255]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein homooligomerization [GO:0051260]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular non-membrane-bounded organelle [GO:0043232]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] AAIDWFDGKEFSGNPIK;GEATVSFDDPPSAK;GGFGPGK 3 7.2 0 3.4498 10.9602 10.7942 0 0 0 0 0 0 11.194 11.6177 10.604 0 P35658 NU214_HUMAN Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; RNA export from nucleus [GO:0006405] cytoplasmic side of nuclear pore [GO:1990876]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] nuclear export signal receptor activity [GO:0005049]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] ETLFNTLANNR;LSPMKQAQLR;QNGTVVQYLPTLQEKK;SLPKVPAK 4 2.2 0.97672 -1.4904 0 0 0 4.9 9.51422 0 0 0 6.3559 0 10.1033 0 P35659 DEK_HUMAN Protein DEK DEK Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079] B-WICH complex [GO:0110016]; contractile muscle fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA binding [GO:0003723] EPFTIAQGK;KADSSTTKK;NVGQFSGFPFEK 3 8 0.73629 0.10953 0 0 0 0 0 0 0 0 0 10.8233 0 0 P35659 DEK_HUMAN Protein DEK DEK Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079] B-WICH complex [GO:0110016]; contractile muscle fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA binding [GO:0003723] EESEEEEDEDDEEEEEEEKGK;EESEEEEDEDDEEEEEEEKGKGQK;KADSSTTKK;NVGQFSGFPFEK 4 13.2 0.94478 -0.64634 0 0 0 0 0 0 12.9359 8.20833 5.38822 0 8.24494 4.63616 P35663 CYLC1_HUMAN Cylicin-1 (Cylicin I) (Multiple-band polypeptide I) CYLC1 CYL CYL1 Homo sapiens (Human) acrosome assembly [GO:0001675]; spermatogenesis [GO:0007283] acrosomal matrix [GO:0043159]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]; sperm head [GO:0061827] structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] EQTPFRHLYTSKTHLK;HLYTSKTHLKK 2 2.6 0.88228 -0.16547 0 0 0 0 7.00843 0 0 0 0 0 0 7.53045 P35670 ATP7B_HUMAN Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] ATP7B PWD WC1 WND Homo sapiens (Human) copper ion export [GO:0060003]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; lactation [GO:0007595]; monoatomic ion transmembrane transport [GO:0034220]; protein maturation by copper ion transfer [GO:0015680]; response to copper ion [GO:0046688]; sequestering of calcium ion [GO:0051208]; viral translational frameshifting [GO:0075523]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581] LSLPTRAWEPAMK;SIEDRISNLK;SPQSTRAVAPQK 3 2.4 0.97905 -1.9012 0 0 0 8.95294 0 0 12.3509 0 7.69377 0 0 0 P35711 SOX5_HUMAN Transcription factor SOX-5 SOX5 Homo sapiens (Human) asymmetric neuroblast division [GO:0055059]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" ILGSRWKAMTNLEK;LAASQIEK;LLAMGSGNFGEIK;QQMELAKQQQEQIAR;STNSPPPK;YPDYKYKPRPK 6 9 0.97826 -1.976 0 0 9.79758 0 0 7.42148 10.83 0 0 11.1896 0 8.34199 P35716 SOX11_HUMAN Transcription factor SOX-11 SOX11 Homo sapiens (Human) brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; closure of optic fissure [GO:0061386]; cornea development in camera-type eye [GO:0061303]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; glial cell proliferation [GO:0014009]; hard palate development [GO:0060022]; kidney development [GO:0001822]; lens morphogenesis in camera-type eye [GO:0002089]; lung morphogenesis [GO:0060425]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of hippo signaling [GO:0035332]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lens epithelial cell proliferation [GO:2001111]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; skeletal muscle cell differentiation [GO:0035914]; soft palate development [GO:0060023]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" TASGHIK;TSKGSSK 2 3.2 0.18975 0.33582 0 0 10.9493 0 0 0 0 0 0 0 8.48583 10.7658 P35749 MYH11_HUMAN "Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)" MYH11 KIAA0866 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; elastic fiber assembly [GO:0048251]; skeletal muscle myosin thick filament assembly [GO:0030241]; smooth muscle contraction [GO:0006939] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307] AEAEAREK;ALAAAAKK;FDQLLAEEK;ICRQGFPNR;KFDQLLAEEK;LDDEIAQK;LEVNMQALK;LLEERISDLTTNLAEEEEKAK;MAEQYKEQAEK;NISSKYADER;NTDQASMPDNTAAQK;QLLQANPILEAFGNAK;QQQLTAMK;TFHIFYYMIAGAKEK;TGVLAHLEEERDLK;TVKNDNSSR;VIQYLAVVASSHKGK 17 9.4 0.97334 -2.4834 7.01514 12.5276 12.7096 0 9.73028 9.90161 12.2895 0 12.136 0 10.0817 7.89403 P35789 ZNF93_HUMAN Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34) ZNF93 ZNF505 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; transposable element silencing [GO:0010526] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AFIASSTLSRHEFIHMGK 1 2.9 0.91748 -0.4295 0 11.4823 0 8.11234 0 0 0 0 0 0 0 0 P35813 PPM1A_HUMAN Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) PPM1A PPPM1A Homo sapiens (Human) cellular response to transforming growth factor beta stimulus [GO:0071560]; dephosphorylation [GO:0016311]; N-terminal protein myristoylation [GO:0006499]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein export from nucleus [GO:0046827]; protein dephosphorylation [GO:0006470]; protein export from nucleus [GO:0006611]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; R-SMAD binding [GO:0070412]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] NDDTDSTSTDDMW;NVIEAVYNR;VCNEVVDTCLYK 3 8.9 0.95884 -1.0098 12.7823 0 12.6207 0 4.13422 0 12.6177 12.4141 13.1213 12.6981 12.7355 10.8424 P35858 ALS_HUMAN Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Homo sapiens (Human) cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor ternary complex [GO:0042567] insulin-like growth factor binding [GO:0005520] DLHFLEELQLGHNRIRQLAER;LEYLLLSRNR;LSHNAIASLRPRTFK 3 7.6 0.98134 -1.5899 10.0348 0 0 0 0 0 0 7.19229 0 0 0 0 P35869 AHR_HUMAN Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) AHR BHLHE76 Homo sapiens (Human) "apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to molecule of bacterial origin [GO:0071219]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell proliferation [GO:0030888]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]" aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic aryl hydrocarbon receptor complex [GO:0034752]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]" LSVLRLSVSYLRAK;LSVSYLR 2 1.7 0.86552 -0.088183 0 0 0 0 0 0 0 3.37016 0 0 0 0 P35900 K1C20_HUMAN "Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)" KRT20 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of protein secretion [GO:0050708] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111] structural constituent of cytoskeleton [GO:0005200] CVLQIDNAK;DAQLQNARCVLQIDNAK;LEQEIATYR;LEQEIATYRR;TLEQSNSKLEVQIK 5 9.7 0.97283 -2.607 0 12.5358 0 9.48246 0 0 0 0 12.3092 0 0 0 P35908 K22E_HUMAN "Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)" KRT2 KRT2A KRT2E Homo sapiens (Human) epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte activation [GO:0032980]; keratinocyte development [GO:0003334]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] AQYEEIAQR;FASFIDK;FASFIDKVR;FLEQQNQVLQTK;GFSSGSAVVSGGSR;GGSGGGGSISGGGYGSGGGSGGR;GGSISGGGYGSGGGK;IEISELNR;NLDLDSIIAEVK;NVQDAIADAEQR;SLVGLGGTK;YLDGLTAER 12 20.7 0 8.9957 11.1958 0 12.6898 9.89851 11.1079 11.1506 12.2504 12.967 12.1207 11.2728 11.297 12.4615 P35913 PDE6B_HUMAN "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)" PDE6B PDEB Homo sapiens (Human) "cAMP-mediated signaling [GO:0019933]; entrainment of circadian clock by photoperiod [GO:0043153]; phototransduction, visible light [GO:0007603]; retina development in camera-type eye [GO:0060041]; retinal cell apoptotic process [GO:1990009]; visual perception [GO:0007601]" photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" ITYHNWR;KDIAQDMVLYHVKCDR;LHGSSILER;LQVGFIDFVCTFVYKEFSR 4 6 0.44392 0.1944 0 0 0 0 8.56293 0 0 0 0 0 0 0 P35914 HMGCL_HUMAN "Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)" HMGCL Homo sapiens (Human) ketone body biosynthetic process [GO:0046951]; L-leucine catabolic process [GO:0006552]; lipid metabolic process [GO:0006629]; mitochondrion organization [GO:0007005] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; structural molecule activity [GO:0005198] LVGLASLRAVSTSSMGTLPK 1 6.2 0.8175 -0.01737 0 0 0 5.80263 0 0 0 0 0 0 0 0 P35916 VGFR3_HUMAN Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) FLT4 VEGFR3 Homo sapiens (Human) blood vessel morphogenesis [GO:0048514]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; lymphangiogenesis [GO:0001946]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; regulation of blood vessel remodeling [GO:0060312]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944] cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GSSCDTVAVKMLKEGATASEHR;MRAPELATPAIR;TEGGARR 3 3 0.97586 -1.4487 0 0 0 0 0 0 6.55316 0 0 0 12.4108 0 P35968 VGFR2_HUMAN Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) KDR FLK1 VEGFR2 Homo sapiens (Human) angiogenesis [GO:0001525]; blood vessel endothelial cell differentiation [GO:0060837]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion homeostasis [GO:0055074]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic hemopoiesis [GO:0035162]; endocardium development [GO:0003157]; endothelial cell differentiation [GO:0045446]; endothelium development [GO:0003158]; epithelial cell maturation [GO:0002070]; epithelial cell proliferation [GO:0050673]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; mesenchymal cell proliferation [GO:0010463]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; ovarian follicle development [GO:0001541]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vasculogenesis [GO:2001214]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein autophosphorylation [GO:0046777]; regulation of bone development [GO:1903010]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of MAPK cascade [GO:0043408]; semaphorin-plexin signaling pathway [GO:0071526]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570] anchoring junction [GO:0070161]; cell junction [GO:0030054]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sorting endosome [GO:0097443] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; integrin binding [GO:0005178]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] DNETLVEDSGIVLK;LVNRDLK;TNLEIIILVGTAVIAMFFWLLLVIILRTVK;VEAFFIIEGAQEK 4 4.7 0.98007 -1.5665 0 0 0 9.58915 0 0 0 10.8535 7.61956 0 0 0 P35998 PRS7_HUMAN 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 MSS1 Homo sapiens (Human) osteoblast differentiation [GO:0001649]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] ALDEGDIALLK;FDDGAGGDNEVQR;FVNLGIEPPK;YVGEGAR 4 9.5 0.91819 -0.40602 0 0 0 0 0 0 0 0 12.6187 0 0 0 P36222 CH3L1_HUMAN Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40) CHI3L1 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to tumor necrosis factor [GO:0071356]; chitin catabolic process [GO:0006032]; inflammatory response [GO:0006954]; lung development [GO:0030324]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to interleukin-1 [GO:0070555]; response to interleukin-6 [GO:0070741]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; specific granule lumen [GO:0035580] carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; extracellular matrix structural constituent [GO:0005201] LVCYYTSWSQYR 1 3.1 0.80684 0.011919 5.8884 0 0 0 0 0 0 0 0 0 0 0 P36269 GGT5_HUMAN Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain] GGT5 GGTLA1 Homo sapiens (Human) amino acid metabolic process [GO:0006520]; fatty acid metabolic process [GO:0006631]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; inflammatory response [GO:0006954]; leukotriene D4 biosynthetic process [GO:1901750]; proteolysis [GO:0006508] plasma membrane [GO:0005886] glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048] LGDPRSHPK;SGEAAGY;VGGAPGR;VGGAPGRCWPPVPGER 4 5.5 0.97463 -1.3931 12.0243 17.9928 3.93725 7.47921 15.4456 15.5909 11.8148 0 11.0466 0 0 11.3489 P36382 CXA5_HUMAN Gap junction alpha-5 protein (Connexin-40) (Cx40) GJA5 Homo sapiens (Human) angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; atrial cardiac muscle cell to AV node cell communication by electrical coupling [GO:0086044]; atrial septum development [GO:0003283]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; cardiac conduction system development [GO:0003161]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; gap junction assembly [GO:0016264]; heart development [GO:0007507]; mitral valve development [GO:0003174]; negative regulation of blood pressure [GO:0045776]; negative regulation of glomerular filtration [GO:0003105]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell communication by chemical coupling [GO:0010652]; positive regulation of vasoconstriction [GO:0045907]; potassium ion transport [GO:0006813]; pulmonary valve formation [GO:0003193]; Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling [GO:0086055]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of AV node cell action potential [GO:0098904]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of Purkinje myocyte action potential [GO:0098906]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasodilation [GO:0042311]; vasomotion [GO:1990029]; ventricular septum development [GO:0003281] cell projection [GO:0042995]; connexin complex [GO:0005922]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886] connexin binding [GO:0071253]; disordered domain specific binding [GO:0097718]; gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling [GO:0086076]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling [GO:0086078]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling [GO:0086079]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; gap junction hemi-channel activity [GO:0055077] IALQGTLLNTYVCSILIR 1 5 0.89857 -0.23145 0 0 0 0 0 8.14578 0 0 0 0 0 0 P36383 CXG1_HUMAN Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) GJC1 GJA7 Homo sapiens (Human) atrial cardiac muscle cell action potential [GO:0086014]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; cardiac muscle tissue development [GO:0048738]; cell development [GO:0048468]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; gap junction assembly [GO:0016264]; muscle contraction [GO:0006936]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasculogenesis [GO:0001570]; visual perception [GO:0007601] connexin complex [GO:0005922]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] gap junction channel activity [GO:0005243]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; monoatomic ion channel activity [GO:0005216] KAKVGSK 1 1.8 0.97736 -1.5227 10.0188 10.0518 0 0 9.87624 0 0 0 0 0 0 0 P36402 TCF7_HUMAN Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1) TCF7 TCF1 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cellular response to interleukin-4 [GO:0071353]; gamma-delta T cell differentiation [GO:0042492]; immune response [GO:0006955]; regulation of DNA-templated transcription [GO:0006355]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357] beta-catenin-TCF complex [GO:1990907]; chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" SSLVNESEGAAGGAGIPGVPGAGAGAR 1 7 0.71271 0.14489 0 0 0 0 0 0 0 0 0 9.42078 0 0 P36405 ARL3_HUMAN ADP-ribosylation factor-like protein 3 ARL3 ARFL3 Homo sapiens (Human) cilium assembly [GO:0060271]; Golgi to plasma membrane transport [GO:0006893]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; mitotic cytokinesis [GO:0000281]; photoreceptor cell development [GO:0042461]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; spindle microtubule [GO:0005876] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017] GLLSILRKLK 1 5.5 0.76664 0.059049 0 0 0 0 0 0 0 0 0 0 4.55293 0 P36406 TRI23_HUMAN E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of autophagy [GO:0010508]; protein ubiquitination [GO:0016567]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] QVTDLGDSGVWGLKK;TLQQDDCRVVLAKQEITR;TTILFKLK 3 7.1 0.7737 0.04765 6.2005 9.26864 12.294 0 7.73755 0 0 7.09286 0 0 0 3.76988 P36537 UDB10_HUMAN UDP-glucuronosyltransferase 2B10 (UDPGT 2B10) (EC 2.4.1.17) UGT2B10 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] UDP-glycosyltransferase activity [GO:0008194] CCLFCFWK;LSDQMTFMERVK;TVINDPSYK 3 5.5 0.87843 -0.14057 0 0 0 0 2.63185 0 0 0 0 0 0 0 P36542 ATPG_HUMAN "ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)" ATP5F1C ATP5C ATP5C1 ATP5CL1 Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; oxidative phosphorylation [GO:0006119]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]" IYGLGSLALYEK 1 4 0.78446 0.018796 0 3.28042 0 0 0 0 0 0 0 0 0 10.7101 P36551 HEM6_HUMAN "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)" CPOX CPO CPX Homo sapiens (Human) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212] AVVPSYIPLVK;GLGHGSTSR;HCDDSFTPQEK;RGRYVEFNLLYDR 4 9.7 0.97994 -1.5611 0 0 12.7268 0 0 0 6.69711 10.6167 9.13255 0 0 11.2531 P36578 RL4_HUMAN Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) RPL4 RPL1 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AAAAAAALQAK;EAVLLLK;IEEVPELPLVVEDK;IEEVPELPLVVEDKVEGYK;IEEVPELPLVVEDKVEGYKK;KAASLKSNYNLPMHK;LAPGGHVGR;MINTDLSR;NIPGITLLNVSK;NVTLPAVFK;QPYAVSELAGHQTSAESWGTGR 11 26.5 0 27.658 14.3582 15.9183 14.1528 10.5181 11.5029 11.3742 13.8251 12.8357 12.7611 13.5307 12.3169 12.5536 P36776 LONM_HUMAN "Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" LONP1 PRSS15 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial genome maintenance [GO:0000002]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]; negative regulation of insulin receptor signaling pathway [GO:0046627]; oxidation-dependent protein catabolic process [GO:0070407]; protein catabolic process [GO:0030163]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis involved in protein catabolic process [GO:0051603]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; DNA polymerase binding [GO:0070182]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; PH domain binding [GO:0042731]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727] YLLQEQLKIIK 1 1.1 0.92368 -0.44814 0 0 0 0 0 0 3.03589 0 0 0 0 0 P36871 PGM1_HUMAN Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) PGM1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose [GO:0033499]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614] LIFTDGSR;LSGTGSAGATIR;LVIGQNGILSTPAVSCIIRKIK;QFSANDKVYTVEK;SIFDFSALK;SMPTSGALDR;TAPTVIT;VSQLQER;YDYEEVEAEGANK 9 18 0.97714 -2.2364 11.6241 9.81921 0 10.5822 7.59268 8.39502 7.92819 0 8.22853 11.198 10.2086 9.99718 P36888 FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) FLT3 CD135 FLK2 STK1 Homo sapiens (Human) animal organ regeneration [GO:0031100]; B cell differentiation [GO:0030183]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to cytokine stimulus [GO:0071345]; cellular response to glucocorticoid stimulus [GO:0071385]; common myeloid progenitor cell proliferation [GO:0035726]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell differentiation [GO:0097028]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; lymphocyte proliferation [GO:0046651]; myeloid progenitor cell differentiation [GO:0002318]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; pro-B cell differentiation [GO:0002328]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine receptor activity [GO:0004896]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; nuclear glucocorticoid receptor binding [GO:0035259]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] EKADSSER;GMEFLEFKSCVHRDLAAR 2 2.6 0.97522 -1.4386 0 0 0 7.65985 0 0 0 0 6.26739 0 0 0 P36894 BMR1A_HUMAN Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) BMPR1A ACVRLK3 ALK3 Homo sapiens (Human) angiogenesis [GO:0001525]; atrioventricular node cell development [GO:0060928]; atrioventricular valve development [GO:0003171]; BMP signaling pathway [GO:0030509]; cardiac conduction system development [GO:0003161]; cardiac right ventricle morphogenesis [GO:0003215]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; central nervous system neuron differentiation [GO:0021953]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digit morphogenesis [GO:0042733]; embryonic organ development [GO:0048568]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial cell proliferation [GO:0050673]; fibrous ring of heart morphogenesis [GO:1905285]; heart formation [GO:0060914]; hindlimb morphogenesis [GO:0035137]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; lateral mesoderm development [GO:0048368]; lung development [GO:0030324]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; Mullerian duct regression [GO:0001880]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neurogenesis [GO:0050768]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell development [GO:0014032]; neural plate mediolateral regionalization [GO:0021998]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; paraxial mesoderm structural organization [GO:0048352]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac ventricle development [GO:1904414]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta2 production [GO:0032915]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cellular senescence [GO:2000772]; regulation of lateral mesodermal cell fate specification [GO:0048378]; roof of mouth development [GO:0060021]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell differentiation [GO:0048863]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" NHFQPYIMADIYSFGLIIWEMARR;PQLYIYIR;TIAKQIQMVRQVGK 3 8.6 0.88282 -0.17515 0 5.45727 0 0 7.36877 0 0 0 0 0 6.85212 0 P36896 ACV1B_HUMAN Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) ACVR1B ACVRLK4 ALK4 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to growth factor stimulus [GO:0071363]; extrinsic apoptotic signaling pathway [GO:0097191]; G1/S transition of mitotic cell cycle [GO:0000082]; hair follicle development [GO:0001942]; in utero embryonic development [GO:0001701]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; negative regulation of ossification [GO:0030279]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of trophoblast cell migration [GO:1901165]; protein autophosphorylation [GO:0046777]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; I-SMAD binding [GO:0070411]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; ubiquitin protein ligase binding [GO:0031625]" VSIFNLDGMEHHVR;YTVTIEGMIK 2 5.3 0.93536 -0.52956 0 10.5938 0 0 8.91522 0 0 0 0 0 0 0 P36915 GNL1_HUMAN Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) GNL1 HSR1 Homo sapiens (Human) DNA damage response [GO:0006974]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456] extracellular space [GO:0005615]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198] ACEAITVGK;VDLSSWREK 2 3 0.98047 -1.6492 0 0 0 0 0 0 0 0 0 0 0 10.5534 P36941 TNR3_HUMAN Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III) LTBR D12S370 TNFCR TNFR3 TNFRSF3 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; hematopoietic or lymphoid organ development [GO:0048534]; immune response [GO:0006955]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] DQEKEYYEPQHR;GPRNQFITHD 2 5.1 0.97857 -2.0598 0 0 0 0 9.049 0 0 0 0 0 7.99152 0 P36955 PEDF_HUMAN Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) SERPINF1 PEDF PIG35 Homo sapiens (Human) cellular response to cobalt ion [GO:0071279]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to retinoic acid [GO:0071300]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; ovulation cycle [GO:0042698]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron projection development [GO:0010976]; response to acidic pH [GO:0010447]; response to arsenic-containing substance [GO:0046685]; response to peptide [GO:1901652]; retina development in camera-type eye [GO:0060041]; short-term memory [GO:0007614] axon hillock [GO:0043203]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase inhibitor activity [GO:0004867] ITGKPIK 1 1.7 0.65128 0.17022 0 0 0 0 0 0 0 5.52716 0 0 0 0 P36956 SRBP1_HUMAN Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] SREBF1 BHLHD1 SREBP1 Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol biosynthetic process [GO:0006695]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; insulin secretion [GO:0030073]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to fructose [GO:0009750]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]" ANGLDAPRAGADR;KAIDYIR;LKQENLSLR;RLLHDCQQMLMR;SRLALCTLVFLCLSCNPLASLLGAR 5 5.6 0.97403 -2.4164 8.63114 0 4.95047 0 0 0 0 0 0 9.07288 10.2457 0 P36956 SRBP1_HUMAN Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] SREBF1 BHLHD1 SREBP1 Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol biosynthetic process [GO:0006695]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; insulin secretion [GO:0030073]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to fructose [GO:0009750]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]" GSGSGGSGSDSEPDSPVFEDSKTE;KAIDYIR;LKQENLSLR 3 9 0.92589 -0.45201 0 0 0 0 0 0 0 0 0 0 0 10.8011 P36957 ODO2_HUMAN "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)" DLST DLTS Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; generation of precursor metabolites and energy [GO:0006091]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252] acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149] AAVEDPR;AAVEDPRVLLLDL;KTGAAPAK;LGFMSAFVK 4 6.6 0.9798 -2.0011 0 0 7.956 0 4.60952 0 0 0 0 14.8046 0 8.53294 P36980 FHR2_HUMAN Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2) CFHR2 CFHL2 FHR2 HFL3 Homo sapiens (Human) complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091] extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802] SGYHPTKSHSFRAMCQNGK 1 7.8 0.96396 -1.0942 0 0 0 0 11.4547 0 0 0 0 0 0 0 P37023 ACVL1_HUMAN Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I) ACVRL1 ACVRLK1 ALK1 Homo sapiens (Human) "angiogenesis [GO:0001525]; artery development [GO:0060840]; blood circulation [GO:0008015]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel maturation [GO:0001955]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral pattern formation [GO:0009953]; endocardial cushion morphogenesis [GO:0003203]; endothelial tube morphogenesis [GO:0061154]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of blood pressure [GO:0008217]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of endothelial cell proliferation [GO:0001936]; response to hypoxia [GO:0001666]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]; venous blood vessel development [GO:0060841]; wound healing, spreading of epidermal cells [GO:0035313]" BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" LAADPVLSGLAQMMR;TLQKISNSPEKPK 2 5.6 0.9175 -0.41983 0 0 0 0 0 0 8.97808 0 0 0 0 8.65718 P37108 SRP14_HUMAN Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) SRP14 Homo sapiens (Human) cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; RNA binding [GO:0003723] ATDGKKK;ISTVVSSK;MVLLESEQFLTELTR;TSGSVYITLK;VLLESEQFLTELTR 5 29.4 0.89765 -0.25277 11.2634 9.92912 10.1294 0 0 9.29581 9.8896 0 0 0 9.27139 0 P37173 TGFR2_HUMAN TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) TGFBR2 Homo sapiens (Human) "aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus morphogenesis [GO:0060434]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to growth factor stimulus [GO:0071363]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic hemopoiesis [GO:0035162]; endocardial cushion fusion [GO:0003274]; epithelial to mesenchymal transition [GO:0001837]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte growth [GO:0003430]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inferior endocardial cushion morphogenesis [GO:1905317]; Langerhans cell differentiation [GO:0061520]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lung lobe morphogenesis [GO:0060463]; mammary gland morphogenesis [GO:0060443]; membranous septum morphogenesis [GO:0003149]; miRNA transport [GO:1990428]; myeloid dendritic cell differentiation [GO:0043011]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pattern specification process [GO:0007389]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell tolerance induction [GO:0002663]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction to self antigen [GO:0002651]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell proliferation [GO:0072091]; response to cholesterol [GO:0070723]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; secondary palate development [GO:0062009]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; trachea formation [GO:0060440]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]" caveola [GO:0005901]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; glycosaminoglycan binding [GO:0005539]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type I transforming growth factor beta receptor binding [GO:0034713]; type III transforming growth factor beta receptor binding [GO:0034714]" FPQLCKFCDVR;LSSTWETGKTR 2 3.9 0.94303 -0.62299 0 11.1385 0 0 0 0 0 0 0 0 0 8.00495 P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; epithelial cell differentiation [GO:0030855]; fatty acid metabolic process [GO:0006631]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; innate immune response [GO:0045087]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extracellular matrix assembly [GO:1901202]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; placenta development [GO:0001890]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of blood pressure [GO:0008217]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipid [GO:0033993]; response to nutrient [GO:0007584]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; white fat cell differentiation [GO:0050872] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "alpha-actinin binding [GO:0051393]; arachidonate binding [GO:0050544]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; nucleic acid binding [GO:0003676]; peptide binding [GO:0042277]; prostaglandin receptor activity [GO:0004955]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]" EVAIRIFQGCQFR 1 2.6 0.91659 -0.41526 0 0 0 0 0 0 0 0 0 10.4723 10.3198 0 P37235 HPCL1_HUMAN Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3) HPCAL1 BDR1 Homo sapiens (Human) regulation of signal transduction [GO:0009966] membrane [GO:0016020] calcium ion binding [GO:0005509] ENTEFTDHELQEWYK;SDPSIVR 2 11.4 0.7833 0.022711 0 0 0 0 0 0 0 0 0 8.15244 0 0 P37275 ZEB1_HUMAN Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) ZEB1 AREB6 TCF8 Homo sapiens (Human) cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to amino acid stimulus [GO:0071230]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; cochlea morphogenesis [GO:0090103]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; keratinocyte proliferation [GO:0043616]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mesenchymal cell proliferation [GO:0010464]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to activity [GO:0014823]; response to nutrient levels [GO:0031667]; semicircular canal morphogenesis [GO:0048752] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" DQRHVTQSGCNR 1 1.1 0.92372 -0.44892 0 0 0 0 0 0 8.38349 0 0 0 0 0 P37287 PIGA_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A) PIGA Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; membrane [GO:0016020] phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; UDP-glycosyltransferase activity [GO:0008194] HDSITIVVVSRLVYRK 1 3.3 0.96497 -1.151 0 0 0 11.4153 0 0 0 0 0 0 0 0 P37802 TAGL2_HUMAN Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) TAGLN2 KIAA0120 CDABP0035 Homo sapiens (Human) actin filament organization [GO:0007015]; epithelial cell differentiation [GO:0030855] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; vesicle [GO:0031982] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] DVGRPQPGR;GASQAGMTGYGMPR;GPAYGLSR;NFSDNQLQEGK;NVIGLQMGTNR;TLMNLGGLAVAR 6 32.7 0 9.5513 0 12.6083 11.8576 8.62972 6.69766 10.1401 12.3334 9.81754 0 12.4348 11.7226 11.4065 P37837 TALDO_HUMAN Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) "carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] monosaccharide binding [GO:0048029]; transaldolase activity [GO:0004801] AAQASDLEK;DAMVARARR;FAADAVK;IYNYYKK;LERMLTER;LLGELLQDNAK;LSSTWEGIQAGK;LVPVLSAK;MESALDQLK;SYEPLEDPGVK;TIVMGASFR;VSTEVDAR 12 32 0 4.4619 11.9886 0 12.9169 0 7.32715 9.86976 12.7132 11.5105 12.5864 13.2663 12.5361 11.1171 P38117 ETFB_HUMAN Electron transfer flavoprotein subunit beta (Beta-ETF) ETFB FP585 Homo sapiens (Human) amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055] EIDGGLETLR;GIHVEVPPAEAER;LGPLQVAR;LGPLQVARVLAKLAEK;LSVISVEDPPQR;TALAMGADR;VEREIDGGLETLR;VETTEDLVAK 8 28.6 0 2.7434 10.9942 11.3932 12.6181 5.00032 0 0 10.2793 12.2737 0 11.1189 9.76979 0 P38159 RBMX_HUMAN "RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]" RBMX HNRPG RBMXP1 Homo sapiens (Human) "cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; osteoblast differentiation [GO:0001649]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; transcription by RNA polymerase II [GO:0006366]" catalytic step 2 spliceosome [GO:0071013]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; supraspliceosomal complex [GO:0044530] chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DDGYSTK;DGYGGSR;DSYESYGNSR;DSYGGPPR;DVYLSPR;GFAFVTFESPADAK;GPPPPPR;GPPPSYGGSSR;LFIGGLNTETNEK;RDVYLSPRDDGYSTK;SDLYSSGR;SGGPPPK;VEADRPGK;VEQATKPSFESGR;YDDYSSSR 15 33 0 5.6501 11.3498 13.1936 12.0383 10.8128 7.33816 5.79069 0 12.0975 0 13.0859 11.2444 10.4664 P38398 BRCA1_HUMAN Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) BRCA1 RNF53 Homo sapiens (Human) cellular response to indole-3-methanol [GO:0071681]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; centrosome cycle [GO:0007098]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of centriole replication [GO:0046600]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ionizing radiation [GO:0010212]; sex-chromosome dosage compensation [GO:0007549] BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; gamma-tubulin ring complex [GO:0000931]; intracellular non-membrane-bounded organelle [GO:0043232]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]; XY body [GO:0001741] damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; enzyme binding [GO:0019899]; histone H2AK127 ubiquitin ligase activity [GO:0140863]; histone H2AK129 ubiquitin ligase activity [GO:0140864]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AAERHPEK;CKKNLLEENFEEHSMSPER;GDVVNGRNHQGPK;MNVEKAEFCNK;VDLNADPLCERK;VTFECEQK 6 3.8 0.97502 -3.1479 0 0 6.43545 9.60652 0 0 10.228 0 0 0 0 0 P38405 GNAL_HUMAN "Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type)" GNAL Homo sapiens (Human) adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] adenylate cyclase regulator activity [GO:0010854]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] ADKPKEKR;DTARTLLPR;EDNNTNRLRESLDLFESIWNNR;LLLLGAGESGK;SIAPITDFEYSQEFFDHVK 5 15.1 0.97506 -3.134 0 9.36757 0 0 0 0 0 0 0 11.6924 11.7267 0 P38432 COIL_HUMAN Coilin (p80-coilin) COIL CLN80 Homo sapiens (Human) spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620] GHPVSCVVNRSTDNQR;VQAVKDWANQRCSSPK;VTLEARNSSEK 3 7.5 0.97317 -2.5856 8.68268 12.6473 11.3426 11.241 0 10.4085 0 11.4458 0 0 12.5309 0 P38567 HYALP_HUMAN Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20) SPAM1 HYAL3 PH20 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; hyaluronan catabolic process [GO:0030214] acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] hyalurononglucosaminidase activity [GO:0004415] KPGYNGSCFNVEIK 1 2.8 0.86709 -0.091758 0 0 0 0 0 0 0 0 0 0 0 11.9993 P38570 ITAE_HUMAN Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain] ITGAE Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229] external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; metal ion binding [GO:0046872] DFISNMMR;YHSLPIIIKGSVGGLLVLIVILVILFK 2 3 0.94163 -0.59757 0 0 0 0 0 0 10.6237 11.4297 0 0 0 0 P38606 VATA_HUMAN V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) ATP6V1A ATP6A1 ATP6V1A1 VPP2 Homo sapiens (Human) cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DDFLQQNGYTPYDRFCPFYK;SDYAQLLEDMQNAFR;VGHSELVGEIIR 3 7.6 0.95238 -0.74099 12.335 0 6.40117 9.40814 0 0 0 0 0 0 0 0 P38646 GRP75_HUMAN "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)" HSPA9 GRP75 HSPA9B mt-HSP70 Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; chaperone cofactor-dependent protein refolding [GO:0051085]; erythrocyte differentiation [GO:0030218]; inner mitochondrial membrane organization [GO:0007007]; intracellular protein transport [GO:0006886]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; positive regulation of apoptotic process [GO:0043065]; protein export from nucleus [GO:0006611]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; MIB complex [GO:0140275]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; SAM complex [GO:0001401]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] AMQDAEVSK;AQFEGIVTDLIR;DAGQISGLNVLR;DNMALQR;DNMALQRVREAAEK;DSETGENIR;ETGVDLTK;LFEMAYK;LVGMPAK;MISASRAAAAR;NAVITVPAYFNDSQR;NTTIPTK;QAASSLQQASLK;QAVTNPNNTFYATK;SDIGEVILVGGMTR;SQVFSTAADGQTQVEIK;STNGDTFLGGEDFDQALLR;TIAPCQK;TIAPCQKAMQDAEVSK;TTPSVVAFTADGER;VINEPTAAALAYGLDK;VLENAEGAR;VQQTVQDLFGR 23 35.9 0 76.691 15.0963 15.0332 14.9472 12.4893 12.4682 12.5659 13.8237 14.0232 13.2864 13.3748 13.61 13.4057 P38919 IF4A3_HUMAN "Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]" EIF4A3 DDX48 KIAA0111 Homo sapiens (Human) "associative learning [GO:0008306]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to selenite ion [GO:0072715]; embryonic cranial skeleton morphogenesis [GO:0048701]; exploration behavior [GO:0035640]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of selenocysteine incorporation [GO:1904570]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to organic cyclic compound [GO:0014070]; rRNA processing [GO:0006364]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; U2-type catalytic step 1 spliceosome [GO:0071006] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; selenocysteine insertion sequence binding [GO:0035368] ATTATMATSGSAR;GIYAYGFEKPSAIQQR;GVAINFVK;VLISTDVWAR 4 11.4 0 48.149 10.2374 9.62542 9.06816 11.8301 10.0477 9.93921 10.1308 10.1283 10.3125 12.0254 12.1927 0 P39019 RS19_HUMAN Small ribosomal subunit protein eS19 (40S ribosomal protein S19) RPS19 Homo sapiens (Human) "antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; erythrocyte differentiation [GO:0030218]; killing of cells of another organism [GO:0031640]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; monocyte chemotaxis [GO:0002548]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; nucleolus organization [GO:0007000]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] fibroblast growth factor binding [GO:0017134]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALAAFLKK;DLDRIAGQVAAANK;DVNQQEFVR;IAGQVAAANK;KLTPQGQR;LTPQGQR;VLQALEGLK;VPEWVDTVK 8 39.3 0 11.793 9.36846 11.4051 11.7931 0 10.5757 10.4632 9.69207 0 0 0 9.78508 0 P39023 RL3_HUMAN Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) RPL3 OK/SW-cl.32 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FIDTTSK;FIDTTSKFGHGR;FQTMEEK;IGQGYLIK;LDWARER;LLPLRQKK;NNASTDYDLSDK;VAFSVAR;VIAHTQMR 9 17.1 0.97213 -1.3579 10.9282 11.4623 11.0507 0 0 0 11.5216 10.5585 11.9772 12.3977 11.8986 11.6951 P39059 COFA1_HUMAN Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)] COL15A1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] basement membrane [GO:0005604]; collagen type XV trimer [GO:0005582]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] GPNGSVGEKGDPGNR;ILDQKAYSCANR 2 1.9 0.9525 -0.76048 10.1426 0 0 0 7.88795 0 0 0 0 0 10.8311 0 P39060 COIA1_HUMAN Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)] COL18A1 Homo sapiens (Human) angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; negative regulation of cell population proliferation [GO:0008285]; notochord development [GO:0030903]; response to hydrostatic pressure [GO:0051599]; response to xenobiotic stimulus [GO:0009410]; skeletal system development [GO:0001501]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] DPQVSPMHCLDEEGDDSDGASGDSGSGLGDAR;RLLDVLAPLVLLLGVR 2 3.6 0.19001 0.33587 0 0 0 0 7.33798 0 0 0 0 0 0 3.5684 P39086 GRIK1_HUMAN "Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)" GRIK1 GLUR5 Homo sapiens (Human) "central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; nervous system development [GO:0007399]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]" intracellular membrane-bounded organelle [GO:0043231]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ELSNILGFIYDVKLVPDGKYGAQNDK;IEYGAVR;IEYGAVRDGSTMTFFK;TLIVTTILEEPYVMYRK 4 6.4 0.97718 -2.1727 7.54071 0 0 0 0 0 10.9834 0 0 0 0 0 P39210 MPV17_HUMAN Mitochondrial inner membrane protein Mpv17 (Protein Mpv17) MPV17 Homo sapiens (Human) cellular response to reactive oxygen species [GO:0034614]; glomerular basement membrane development [GO:0032836]; homeostatic process [GO:0042592]; inner ear development [GO:0048839]; mitochondrial genome maintenance [GO:0000002]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of reactive oxygen species metabolic process [GO:2000377] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] channel activity [GO:0015267] AYQRALAAHPWK 1 6.8 0.92368 -0.44961 7.58007 0 0 8.14216 0 0 0 0 0 0 0 0 P39656 OST48_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) DDOST KIAA0115 OST48 OK/SW-cl.45 Homo sapiens (Human) protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]; response to cytokine [GO:0034097]; T cell activation [GO:0042110] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047] NTLLIAGLQAR;SSLNPILFR;TADDPSLSLIK 3 6.8 0.031365 0.57068 11.9314 11.4356 0 9.28263 0 9.92604 0 0 10.716 8.62234 8.9569 0 P39687 AN32A_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) ANP32A C15orf1 LANP MAPM PHAP1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone binding [GO:0042393]; RNA binding [GO:0003723] DLSTIEPLK;ELVLDNSR;EPEDEGEDDD;TPSDVKELVLDNSR;VSGGLEVLAEK 5 17.7 0.95567 -0.82755 0 0 0 0 0 0 0 0 0 11.3911 11.2954 0 P39748 FEN1_HUMAN Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) FEN1 RAD2 Homo sapiens (Human) "base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; memory [GO:0007613]; nucleic acid metabolic process [GO:0090304]; positive regulation of sister chromatid cohesion [GO:0045876]; telomere maintenance via semi-conservative replication [GO:0032201]; UV protection [GO:0009650]" "chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523] GIQGLAKLIADVAPSAIR;LIADVAPSAIR;LIADVAPSAIRENDIK;QLQQAQAAGAEQEVEK;RAVDLIQKHK;SIEEIVR 6 14.7 0.97623 -1.4806 10.1529 0 0 0 0 0 10.4754 0 0 9.93348 8.33181 0 P39877 PA2G5_HUMAN Phospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5) PLA2G5 Homo sapiens (Human) arachidonate secretion [GO:0050482]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; leukotriene biosynthetic process [GO:0019370]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phagosome-lysosome fusion [GO:0090385]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagosome maturation [GO:1905164]; positive regulation of phospholipase activity [GO:0010518] early phagosome [GO:0032009]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipid binding [GO:0005543] DGTDWCCWAHDHCYGR;TQSYKYR 2 16.7 0.96778 -1.3193 0 0 3.46728 0 0 0 0 5.71169 0 0 4.6017 5.93348 P39900 MMP12_HUMAN Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12) MMP12 HME Homo sapiens (Human) "bronchiole development [GO:0060435]; cellular response to virus [GO:0098586]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; lung alveolus development [GO:0048286]; negative regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904905]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; regulation of defense response to virus by host [GO:0050691]; response to amyloid-beta [GO:1904645]; wound healing, spreading of epidermal cells [GO:0035313]" cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; core promoter sequence-specific DNA binding [GO:0001046]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] DRFFWLK;FYGLEINK;KAFQVWSNVTPLK;YSGNLMKEK 4 7.9 0.97513 -4.0252 12.6283 0 13.7247 9.46982 0 0 0 0 0 0 0 10.4803 P40121 CAPG_HUMAN Macrophage-capping protein (Actin regulatory protein CAP-G) CAPG AFCP MCP Homo sapiens (Human) actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; protein-containing complex assembly [GO:0065003] actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; Flemming body [GO:0090543]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] "actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]" QAALQVAEGFISR 1 3.7 0.0047733 1.4994 0 0 0 0 0 0 0 0 11.5838 0 0 0 P40123 CAP2_HUMAN Adenylyl cyclase-associated protein 2 (CAP 2) CAP2 Homo sapiens (Human) actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; presynaptic actin cytoskeleton organization [GO:0099140]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179]; identical protein binding [GO:0042802] MANMQGLVERLER;SSEMNILIPQDGDYREFPIPEQFK 2 7.8 0.95254 -0.67894 0 0 0 0 0 0 0 0 0 0 11.0268 11.0005 P40126 TYRP2_HUMAN L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2) DCT TYRP2 Homo sapiens (Human) cell development [GO:0048468]; developmental pigmentation [GO:0048066]; epidermis development [GO:0008544]; melanin biosynthetic process from tyrosine [GO:0006583]; positive regulation of neuroblast proliferation [GO:0002052]; response to blue light [GO:0009637]; ventricular zone neuroblast division [GO:0021847] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886] copper ion binding [GO:0005507]; dopachrome isomerase activity [GO:0004167]; oxidoreductase activity [GO:0016491] CTGNFAGYNCGDCK;KKPPVIR;RNQMGRNSMK 3 6 0.97569 -2.3482 0 0 0 0 0 8.74719 0 0 0 5.00356 0 0 P40145 ADCY8_HUMAN Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY8 Homo sapiens (Human) activation of protein kinase A activity [GO:0034199]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to morphine [GO:0071315]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; memory [GO:0007613]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synaptic plasticity [GO:0031915]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cellular response to stress [GO:0080135]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] actin binding [GO:0003779]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721] SASRPQR 1 0.6 0.91206 -0.3227 0 0 0 0 0 0 0 8.85153 0 0 0 0 P40189 IL6RB_HUMAN Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) IL6ST Homo sapiens (Human) cell surface receptor signaling pathway via STAT [GO:0097696]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of neuron apoptotic process [GO:0043524]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of vascular endothelial growth factor production [GO:0010575]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540] ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor activity [GO:0004897]; ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-27 receptor activity [GO:0045509]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110] EQYTIINR;SEWATHKFADCKAK;TLPPFEANGK;VTSDHINFDPVYK 4 4.9 0.97309 -1.3721 0 0 0 0 6.18283 0 0 0 0 0 9.7185 0 P40197 GPV_HUMAN Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d) GP5 Homo sapiens (Human) "blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]" extracellular exosome [GO:0070062]; glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886] GLLGAQAKLERLLLHSNR;SIAPGAFDR 2 4.8 0.90442 -0.26866 0 9.19572 8.78185 0 0 0 0 0 0 10.6433 0 0 P40205 NCYM_HUMAN N-cym protein (N-myc opposite strand) MYCNOS CYMN NCYM Homo sapiens (Human) negative regulation of kinase activity [GO:0033673]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; nucleus [GO:0005634] LLLCNYER 1 7.3 0.93703 -0.54204 0 0 0 9.4445 0 0 0 0 0 0 0 0 P40222 TXLNA_HUMAN Alpha-taxilin TXLNA TXLN Homo sapiens (Human) B cell activation [GO:0042113]; exocytosis [GO:0006887] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020] syntaxin binding [GO:0019905] ALQTERNDLNK;KAKGLGK;LAALCKK;LESLCRELQR;LIEQYELR;SLKEEGVQR 6 9.5 0.97478 -2.4001 0 0 0 14.4892 0 0 0 0 0 0 13.3615 7.69704 P40225 TPO_HUMAN Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand) THPO MGDF Homo sapiens (Human) cell population proliferation [GO:0008283]; cell surface receptor signaling pathway via STAT [GO:0097696]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; thrombopoietin-mediated signaling pathway [GO:0038163] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] ELTELLLVVMLLLTAR 1 4.5 0.60925 0.17549 0 0 0 0 6.68734 0 9.35078 0 0 0 0 0 P40227 TCPZ_HUMAN T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) CCT6A CCT6 CCTZ Homo sapiens (Human) chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; WD40-repeat domain binding [GO:0071987] AAVKTLNPK;GIDPFSLDALSK;IITEGFEAAK;IITEGFEAAKEK;QADLYISEGLHPRIITEGFEAAK;SETDTSLIR;VEDAYILTCNVSLEYEK 7 13.6 0.936 -0.54667 0 11.6548 11.8365 0 0 0 11.809 11.6824 10.8393 12.5553 11.7071 10.5403 P40238 TPOR_HUMAN Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) MPL TPOR Homo sapiens (Human) basophil homeostasis [GO:1990960]; cellular response to hypoxia [GO:0071456]; eosinophil homeostasis [GO:1990959]; immunoglobulin mediated immune response [GO:0016064]; monocyte homeostasis [GO:0035702]; neutrophil homeostasis [GO:0001780]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of platelet formation [GO:1905221]; thrombopoietin-mediated signaling pathway [GO:0038163] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] thrombopoietin receptor activity [GO:0038164] LNGPTYQGPWSSWSDPTR;YPIWENCEEEEK;YRLQLRAR 3 6 0.97507 -1.4394 0 0 0 11.2962 0 0 2.78628 0 0 6.5157 0 2.9824 P40259 CD79B_HUMAN B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b) CD79B B29 IGB Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; signal transduction [GO:0007165] B cell receptor complex [GO:0019815]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; IgM B cell receptor complex [GO:0071755]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] FEDNGIYFCQQK 1 5.2 0.80652 0.0080024 9.98883 0 0 0 0 0 0 0 0 0 0 0 P40261 NNMT_HUMAN Nicotinamide N-methyltransferase (EC 2.1.1.1) NNMT Homo sapiens (Human) animal organ regeneration [GO:0031100]; methylation [GO:0032259]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide metabolic process [GO:0006769]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein deacetylation [GO:0090312]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829] nicotinamide N-methyltransferase activity [GO:0008112]; pyridine N-methyltransferase activity [GO:0030760] FSSLPLGR;HSAESQILK 2 6.4 0.0048662 1.5932 0 0 0 0 11.3798 11.2938 13.1485 12.8608 0 12.3499 9.1153 0 P40306 PSB10_HUMAN Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i) PSMB10 LMP10 MECL1 Homo sapiens (Human) cell morphogenesis [GO:0000902]; humoral immune response [GO:0006959]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; T cell proliferation [GO:0042098] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111]" endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298] IHFIAPK 1 2.6 0.91001 -0.31185 0 0 7.89633 0 0 0 0 0 0 0 0 0 P40313 CTRL_HUMAN Chymotrypsin-like protease CTRL-1 (EC 3.4.21.-) CTRL CTRL1 Homo sapiens (Human) protein catabolic process [GO:0030163]; proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LASPAQYTTR 1 3.8 0.92875 -0.47199 12.2794 0 0 0 0 0 0 0 0 0 0 0 P40337 VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) VHL Homo sapiens (Human) amyloid fibril formation [GO:1990000]; cell morphogenesis [GO:0000902]; cellular response to hypoxia [GO:0071456]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] EAGRPRPVLR;IAHQRMGD 2 11.2 0.97992 -1.8303 12.5187 9.2962 0 0 0 0 0 0 0 0 0 0 P40394 ADH7_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase) ADH7 Homo sapiens (Human) fatty acid omega-oxidation [GO:0010430]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; plasma membrane [GO:0005886] alcohol dehydrogenase (NAD+) activity [GO:0004022]; aldehyde oxidase activity [GO:0004031]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; ethanol binding [GO:0035276]; omega-hydroxydecanoate dehydrogenase activity [GO:0050153]; receptor antagonist activity [GO:0048019]; retinol binding [GO:0019841]; zinc ion binding [GO:0008270] ETLDMVFQR;IDDAAPPEK 2 4.6 0.96336 -1.0847 0 0 0 0 9.60827 0 0 0 8.90123 0 0 0 P40425 PBX2_HUMAN Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) PBX2 G17 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FSAIQMQLK;HALNCHR 2 3.7 0.88111 -0.15139 0 0 0 0 0 0 0 0 0 4.12325 8.8042 10.8049 P40429 RL13A_HUMAN Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) RPL13A Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; cytoplasmic translation [GO:0002181]; homeostatic process [GO:0042592]; lung morphogenesis [GO:0060425]; macrophage chemotaxis [GO:0048246]; negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; response to lipopolysaccharide [GO:0032496]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; GAIT complex [GO:0097452]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AKIHYRK;GHLLGRLAAIVAKQVLLGR;LAAIVAK;MNTNPSR;MVVPAALK;VFDGIPPPYDK;VFDGIPPPYDKK;YQAVTATLEEK 8 31.5 0.0024691 1.6479 10.7004 13.0421 5.46604 10.1018 9.8993 10.8423 11.8296 12.4341 13.1954 12.5582 11.4605 12.194 P40616 ARL1_HUMAN ADP-ribosylation factor-like protein 1 ARL1 Homo sapiens (Human) "Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; toxin metabolic process [GO:0009404]; vesicle-mediated transport [GO:0016192]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] enzyme activator activity [GO:0008047]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipase D activator activity [GO:1990583]; protein domain specific binding [GO:0019904] GTGLDEAMEWLVETLK 1 8.8 0.22356 0.30844 0 10.5977 0 8.36023 0 0 11.904 0 11.7422 0 0 11.2274 P40692 MLH1_HUMAN DNA mismatch repair protein Mlh1 (MutL protein homolog 1) MLH1 COCA2 Homo sapiens (Human) double-strand break repair via nonhomologous end joining [GO:0006303]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; male meiosis chromosome segregation [GO:0007060]; meiotic metaphase I homologous chromosome alignment [GO:0043060]; meiotic spindle midzone assembly [GO:0051257]; meiotic telomere clustering [GO:0045141]; mismatch repair [GO:0006298]; negative regulation of mitotic recombination [GO:0045950]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oogenesis [GO:0048477]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; resolution of meiotic recombination intermediates [GO:0000712]; response to bacterium [GO:0009617]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spermatogenesis [GO:0007283] chiasma [GO:0005712]; chromosome [GO:0005694]; late recombination nodule [GO:0005715]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137] KCIFLLFINHR;YSVHNAGISFSVKK 2 3.3 0.8918 -0.21551 9.21764 0 0 0 0 0 0 0 0 0 0 15.0251 P40763 STAT3_HUMAN Signal transducer and activator of transcription 3 (Acute-phase response factor) STAT3 APRF Homo sapiens (Human) astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to hormone stimulus [GO:0032870]; cellular response to interleukin-17 [GO:0097398]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; retinal rod cell differentiation [GO:0060221]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; temperature homeostasis [GO:0001659]; transforming growth factor beta receptor signaling pathway [GO:0007179] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; nuclear receptor activity [GO:0004879]; primary miRNA binding [GO:0070878]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA sequestering activity [GO:0140610]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]" FNILGTNTK;SAFVVER;TGVQFTTK;VMNMEESNNGSLSAEFKHLTLR 4 6 0.95509 -0.86479 0 9.77357 7.67892 0 0 0 0 0 8.8443 0 0 0 P40818 UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) USP8 KIAA0055 UBPY Homo sapiens (Human) "cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; SH3 domain binding [GO:0017124] DSLKKIEIWK;EEMEKKESEQAK;GSLENVLDSKDKTQK;IEIWKLPPVLLVHLKR;INDQFAGYSQQDSQELLLFLMDGLHEDLNK;KIEIWKLPPVLLVHLK;RQSKSEHETSDAK;TAEECRLDR;YVTVYNLIK 9 9.7 0.98085 -2.0243 10.5149 0 0 0 8.74191 6.19785 6.20152 0 10.1541 0 9.12526 0 P40855 PEX19_HUMAN Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 HK33 PXF OK/SW-cl.22 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier chaperone [GO:0140597] FPREVFPGTIR 1 27.5 0.97763 -1.5178 0 0 0 0 0 0 13.0131 0 0 0 0 0 P40879 S26A3_HUMAN Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) SLC26A3 DRA Homo sapiens (Human) cellular response to cAMP [GO:0071320]; chloride transmembrane transport [GO:1902476]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; sperm capacitation [GO:0048240]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] EINQRFKDK;QGLLQVTPK;SILQEFIRIK 3 3.7 0.97653 -2.2849 0 0 0 0 0 0 0 0 0 0 0 11.3046 P40925 MDHC_HUMAN "Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)" MDH1 MDHA Homo sapiens (Human) malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] diiodophenylpyruvate reductase activity [GO:0047860]; hydroxyphenylpyruvate reductase activity [GO:0047995]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; malic enzyme activity [GO:0004470] DLDVAILVGSMPRR;ESAFEFLSSA;FVEGLPINDFSR;KLSSAMSAAKAICDHVR;LGVTANDVK;LSSAMSAAK;SQGAALDK;YAKKSVK 8 23.1 0.88195 -0.15863 12.9966 12.9965 12.6925 10.3799 9.93631 9.80105 0 12.1775 12.068 13.2366 10.6288 0 P40926 MDHM_HUMAN "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" MDH2 Homo sapiens (Human) aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; NADH metabolic process [GO:0006734]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; L-malate dehydrogenase (NADP+) activity [GO:0046554]; RNA binding [GO:0003723] ANTFVAELK;HGVYNPNK;IFGVTTLDIVR;IQEAGTEVVK;MISDAIPELK;TIIPLISQCTPK;VAVLGASGGIGQPLSLLLK;VDFPQDQLTALTGR;VNVPVIGGHAGK;VSSFEEK 10 33.1 0 48.914 12.1097 13.4248 13.9037 10.6971 9.66772 11.2314 8.41663 10.5842 11.7498 0 0 13.4193 P40933 IL15_HUMAN Interleukin-15 (IL-15) IL15 Homo sapiens (Human) cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; extrathymic T cell selection [GO:0045062]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of cold-induced thermogenesis [GO:0120163]; neutrophil activation [GO:0042119]; NK T cell proliferation [GO:0001866]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immune response [GO:0050778]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein O-linked glycosylation [GO:1904100]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; regulation of defense response to virus by host [GO:0050691]; regulation of T cell differentiation [GO:0045580]; signal transduction [GO:0007165]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] ECEELEEK 1 4.9 0.89156 -0.21443 0 7.84762 7.75255 9.25743 0 8.42232 7.94615 0 8.21398 10.8609 11.1154 9.79053 P40937 RFC5_HUMAN Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) RFC5 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme binding [GO:0019899] LEHVVEEEK 1 2.6 0.90945 -0.31454 0 0 0 0 0 0 4.07451 0 0 0 0 10.7558 P40938 RFC3_HUMAN Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) RFC3 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]" AIYHLEAFVAK;DFKVVLLTEVDK;VVLLTEVDK 3 6.5 0.96378 -1.2052 0 0 0 0 0 0 0 0 10.1737 10.0877 7.61206 0 P40938 RFC3_HUMAN Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) RFC3 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]" DFKVVLLTEVDK;EESRSCDIF;VVLLTEVDK 3 6.9 0.90286 -0.26498 0 5.92291 0 0 0 0 0 0 0 0 0 0 P40939 ECHA_HUMAN "Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]" HADHA HADH Homo sapiens (Human) cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410] mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; protein-containing complex binding [GO:0044877] DTSASAVAVGLK;FGGGNPELLTQMVSK;FVDLYGAQK;GDVAVVR;ILQEGVDPK;KYEAAYGK;LTAYAMTIPFVR;TVLGTPEVLLGALPGAGGTQR 8 12.2 0 6.6575 0 0 0 7.83964 7.50216 0 8.07152 8.18354 0 10.5222 11.9846 10.3898 P41002 CCNF_HUMAN Cyclin-F (F-box only protein 1) CCNF FBX1 FBXO1 Homo sapiens (Human) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of centrosome duplication [GO:0010826]; placenta development [GO:0001890]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cell junction [GO:0030054]; centriole [GO:0005814]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005] anaphase-promoting complex binding [GO:0010997]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] CFCYPTK 1 0.9 0.90985 -0.3178 0 0 0 0 0 0 0 0 0 11.1683 0 0 P41091 IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) EIF2S3 EIF2G Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062] "cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; methionyl-initiator methionine tRNA binding [GO:1990856]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" AGGEAGVTLGQPHLSR;GVTIKPTVDDD;IPVPPRDFTSEPR;QDLTTLDVTK;VGQEIEVRPGIVSK 5 13.6 0 10.904 0 0 8.59395 0 9.36284 0 0 10.9346 10.1805 0 11.6687 0 P41134 ID1_HUMAN DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) ID1 BHLHB24 ID Homo sapiens (Human) angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription by transcription factor localization [GO:0010621]; neuron differentiation [GO:0030182]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein dimerization activity [GO:0046983]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] CAGGAGAR;ELVPTLPQNRK 2 12.3 0.95572 -0.84254 0 0 0 0 5.95077 0 0 0 0 0 0 6.55187 P41143 OPRD_HUMAN Delta-type opioid receptor (D-OR-1) (DOR-1) OPRD1 OPRD Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adult locomotory behavior [GO:0008344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cellular response to toxic substance [GO:0097237]; eating behavior [GO:0042755]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; negative regulation of gene expression [GO:0010629]; negative regulation of protein-containing complex assembly [GO:0031333]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of calcium ion transport [GO:0051924]; regulation of mitochondrial membrane potential [GO:0051881]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]" axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; spine apparatus [GO:0097444]; synaptic vesicle membrane [GO:0030672] G protein-coupled enkephalin receptor activity [GO:0038046]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612] EATARER 1 1.9 0.89835 -0.25701 12.1773 0 0 0 0 0 0 0 9.26442 0 0 0 P41145 OPRK_HUMAN Kappa-type opioid receptor (K-OR-1) (KOR-1) OPRK1 OPRK Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to cocaine [GO:0048148]; cellular response to glucose stimulus [GO:0071333]; cellular response to lipopolysaccharide [GO:0071222]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; defense response to virus [GO:0051607]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; immune response [GO:0006955]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; negative regulation of luteinizing hormone secretion [GO:0033685]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of eating behavior [GO:1904000]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of saliva secretion [GO:0046877]; response to acrylamide [GO:1903937]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to nicotine [GO:0035094]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951] axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sarcoplasmic reticulum [GO:0016529]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315] dynorphin receptor activity [GO:0038048]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612] MRMERQSTSR 1 2.6 0.76729 0.059369 0 0 0 0 8.18339 0 0 9.0926 0 0 0 0 P41161 ETV5_HUMAN ETS translocation variant 5 (Ets-related protein ERM) ETV5 ERM Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; male germ-line stem cell asymmetric division [GO:0048133]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" QEPTMYREGPPYQRR;SLRYYYEK 2 4.5 0.96472 -1.1518 0 0 0 0 6.58453 0 0 0 0 0 0 0 P41162 ETV3_HUMAN ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) ETV3 METS PE1 Homo sapiens (Human) cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; negative regulation of cell population proliferation [GO:0008285]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] "DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" ALRYYYNK;EPSAPEKK;FNFNKLVMPNYPFINIR;KEDALMPPK 4 8 0.95258 -0.76434 0 0 0 0 0 9.07422 0 0 0 0 9.049 10.4828 P41180 CASR_HUMAN Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) CASR GPRC2A PCAR1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chemosensory behavior [GO:0007635]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; regulation of presynaptic membrane potential [GO:0099505]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol phospholipase C activity [GO:0004435]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325] ILWSGFSR;VEAWQVLK;VLLVFEAKIPTSFHRK 3 3 0.97635 -2.1857 0 0 0 0 0 10.8718 11.6686 0 0 8.85879 0 0 P41182 BCL6_HUMAN B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) BCL6 BCL5 LAZ3 ZBTB27 ZNF51 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; DNA damage response [GO:0006974]; erythrocyte development [GO:0048821]; germinal center formation [GO:0002467]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth [GO:0030308]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mitotic cell cycle DNA replication [GO:1903464]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell motility [GO:2000147]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein localization [GO:0008104]; pyramidal neuron differentiation [GO:0021859]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of germinal center formation [GO:0002634]; regulation of immune response [GO:0050776]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; regulation of memory T cell differentiation [GO:0043380]; regulation of T cell proliferation [GO:0042129]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; T-helper 2 cell differentiation [GO:0045064]; transcription by RNA polymerase II [GO:0006366]; type 2 immune response [GO:0042092] Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] "chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]" YKGNLASHK 1 1.3 0.97531 -1.4729 0 0 0 0 0 0 11.3337 0 0 0 0 0 P41208 CETN2_HUMAN Centrin-2 (Caltractin isoform 1) CETN2 CALT CEN2 Homo sapiens (Human) cell division [GO:0051301]; centriole replication [GO:0007099]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; nucleotide-excision repair [GO:0006289]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283] 9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]; XPC complex [GO:0071942] calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017] ALGFEPK;KMISEIDKEGTGK 2 11.6 0.96737 -1.3059 12.6147 0 0 0 0 8.28221 9.3779 8.60737 0 0 8.47013 0 P41214 EIF2D_HUMAN Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) EIF2D HCA56 LGTN Homo sapiens (Human) formation of translation preinitiation complex [GO:0001731]; intracellular protein transport [GO:0006886]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604] RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; translation initiation factor activity [GO:0003743] SSPPSIAPLALDSADLSEEK;TIVINYAK 2 4.8 0.93316 -0.51364 0 0 5.31198 0 0 0 0 0 0 0 0 0 P41217 OX2G_HUMAN OX-2 membrane glycoprotein (CD antigen CD200) CD200 MOX1 MOX2 My033 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage migration [GO:1905522]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell migration [GO:2000405]; positive regulation of arginase activity [GO:0150072]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of immune response [GO:0050776]; regulation of neuroinflammatory response [GO:0150077] axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632]; glycosylated region protein binding [GO:0140081]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080] HRNQDREP 1 3 0.97622 -1.487 0 0 0 0 0 0 0 11.4958 0 0 0 0 P41218 MNDA_HUMAN Myeloid cell nuclear differentiation antigen MNDA Homo sapiens (Human) activation of innate immune response [GO:0002218]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; cellular response to interferon-beta [GO:0035458]; DNA damage response [GO:0006974]; negative regulation of B cell proliferation [GO:0030889]; positive regulation of apoptotic process [GO:0043065] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] double-stranded DNA binding [GO:0003690] ITDLMEK;MVNEYKKILLLK 2 4.7 0.95282 -0.73699 0 0 0 0 0 7.66541 0 0 0 0 0 0 P41219 PERI_HUMAN Peripherin (Neurofilament 4) PRPH NEF4 PRPH1 Homo sapiens (Human) axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; type III intermediate filament [GO:0045098] structural molecule activity [GO:0005198] DIRAQYESIAAK;KLLEGEESR;LEEETRK;LLEGEESR;NLQEAEEWYK 5 8.1 0.97504 -1.3825 0 0 0 0 0 0 0 0 0 0 0 12.3191 P41220 RGS2_HUMAN Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8) RGS2 G0S8 GIG31 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; G protein-coupled receptor signaling pathway [GO:0007186]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phospholipase activity [GO:0010519]; negative regulation of translation [GO:0017148]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of neuron projection development [GO:0010976]; regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071877]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; relaxation of cardiac muscle [GO:0055119]; relaxation of vascular associated smooth muscle [GO:0060087]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenylate cyclase inhibitor activity [GO:0010855]; beta-tubulin binding [GO:0048487]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] IYTDFIEK 1 3.8 0.9346 -0.53066 0 0 0 0 11.0057 0 0 0 0 0 0 0 P41225 SOX3_HUMAN Transcription factor SOX-3 SOX3 Homo sapiens (Human) brain development [GO:0007420]; central nervous system development [GO:0007417]; face development [GO:0060324]; hypothalamus development [GO:0021854]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; pituitary gland development [GO:0021983]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; sex determination [GO:0007530] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EYPDYKYRPR;VPADLAR 2 3.8 0.97669 -2.2428 0 0 0 0 0 0 9.08736 0 0 0 0 0 P41227 NAA10_HUMAN N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) NAA10 ARD1 ARD1A TE2 Homo sapiens (Human) "chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000719]; protein acetylation [GO:0006473]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634] N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-alanine-alpha-N-acetyltransferase activity [GO:0008999]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189] DLSEVSETTESTDVK;DSSEASDSAS;ISEVEPK 3 14.5 0.93023 -0.48675 0 0 0 10.3031 0 0 0 0 9.05796 11.4147 11.3412 0 P41229 KDM5C_HUMAN Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) KDM5C DXS1272E JARID1C SMCX XE169 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; zinc ion binding [GO:0008270] AISWQGR;CVMAECK;ILDLYSLSKIVVEEGGYEAICK;LNYLDQIAK;NIGSLLRSHYER;QSVQPSKFNSYGRR;SRRPRLETILALLVALQR;TLAPSAR 8 6.2 0.97541 -3.5884 9.80911 12.9716 0 0 10.0399 0 0 11.6949 9.86871 8.79915 0 11.0393 P41231 P2RY2_HUMAN P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) P2RY2 P2RU1 Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; cellular response to ATP [GO:0071318]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular monoatomic ion homeostasis [GO:0006873]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of mucus secretion [GO:0070257] plasma membrane [GO:0005886] A1 adenosine receptor binding [GO:0031686]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UTP receptor activity [GO:0045030]; signaling receptor activity [GO:0038023] SLRWGRAR;TLYYSFR 2 4 0.98044 -1.8131 0 0 0 0 0 10.186 0 0 0 0 0 0 P41235 HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) HNF4A HNF4 NR2A1 TCF14 Homo sapiens (Human) blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; phospholipid homeostasis [GO:0055091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gastrulation [GO:0010470]; regulation of growth hormone receptor signaling pathway [GO:0060398]; regulation of insulin secretion [GO:0050796]; regulation of lipid metabolic process [GO:0019216]; regulation of ornithine metabolic process [GO:0090368]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; rhythmic process [GO:0048511]; sex differentiation [GO:0007548]; signal transduction involved in regulation of gene expression [GO:0023019]; transcription by RNA polymerase II [GO:0006366]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; fatty acid binding [GO:0005504]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" EAVQNER;ILDELVLPFQELQIDDNEYAYLK;LLPGAVATIVKPLSAIPQPTITKQEVI;QCVVDKDK 4 13.7 0.73226 0.11526 0 9.96852 0 0 9.55173 0 0 9.5075 0 0 0 0 P41238 ABEC1_HUMAN C->U-editing enzyme APOBEC-1 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic subunit 1) (APO1) (APOBEC-1) (Apolipoprotein B mRNA-editing enzyme 1) (EC 3.5.4.36) (HEPR) (mRNA(cytosine(6666)) deaminase 1) APOBEC1 Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; cytidine to uridine editing [GO:0016554]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein transport [GO:0042953]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; regulation of cell population proliferation [GO:0042127]; response to gamma radiation [GO:0010332]; triglyceride metabolic process [GO:0006641]" apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cytidine deaminase activity [GO:0004126]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EACLLYEIKWGMSR 1 5.9 0.82929 -0.022938 0 0 0 0 6.65363 0 0 0 0 0 0 0 P41240 CSK_HUMAN Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) CSK Homo sapiens (Human) adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; proline-rich region binding [GO:0070064]; protein kinase A catalytic subunit binding [GO:0034236]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782] EGIIPANYVQKR 1 2.7 0.83662 -0.034354 0 0 0 0 0 0 0 0 0 0 0 10.8667 P41250 GARS_HUMAN Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) GARS1 GARS Homo sapiens (Human) diadenosine tetraphosphate biosynthetic process [GO:0015966]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]; tRNA aminoacylation for protein translation [GO:0006418] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; secretory granule [GO:0030141] ATP binding [GO:0005524]; ATP:ATP adenylyltransferase activity [GO:0141192]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; glycine-tRNA ligase activity [GO:0004820]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983] APQVDVDK;FRQHMENEMAHYACDCWDAESK;IYLYLTK;MDGAGAEEVLAPLR;QHMENEMAHYACDCWDAESK;TFFSFPAVVAPFK;TPHTATLRDRDSMR;TVNVVQFEPSK;VDDSSGSIGR 9 14.5 0 21.315 11.3414 11.9693 12.1551 9.15135 0 8.6471 0 9.89218 11.2106 12.2359 12.8181 0 P41273 TNFL9_HUMAN Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL) TNFSF9 Homo sapiens (Human) cell-cell signaling [GO:0007267]; immune response [GO:0006955]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; regulation of apoptotic process [GO:0042981]; regulation of T cell proliferation [GO:0042129] extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813] EGPELSPDDPAGLLDLR 1 6.7 0.76768 0.057164 0 0 0 0 0 0 0 0 6.64011 0 0 0 P41439 FOLR3_HUMAN Folate receptor gamma (FR-gamma) (Folate receptor 3) FOLR3 Homo sapiens (Human) cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] folic acid binding [GO:0005542]; signaling receptor activity [GO:0038023] EDCERWWEDCR 1 4.5 0.83566 -0.030953 0 0 0 5.54856 0 0 0 0 0 0 0 0 P41439 FOLR3_HUMAN Folate receptor gamma (FR-gamma) (Folate receptor 3) FOLR3 Homo sapiens (Human) cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] folic acid binding [GO:0005542]; signaling receptor activity [GO:0038023] AGAKSAF 1 4.1 0.69821 0.16203 0 0 0 0 10.7616 11.175 12.392 0 0 12.9929 0 0 P41586 PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) ADCYAP1R1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP-mediated signaling [GO:0019933]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; development of primary female sexual characteristics [GO:0046545]; multicellular organismal response to stress [GO:0033555]; negative regulation of response to reactive oxygen species [GO:1901032]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283] bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell surface [GO:0009986]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] adenylate cyclase binding [GO:0008179]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; pituitary adenylate cyclase-activating polypeptide receptor activity [GO:0001634]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; vasoactive intestinal polypeptide receptor activity [GO:0004999] LVFELGLGSFQGFVVAVLYCFLNGEVQAEIKR 1 6.8 0.35895 0.23307 0 0 0 0 0 0 7.61375 0 0 0 0 0 P41587 VIPR2_HUMAN Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) VIPR2 VIP2R Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide hormone binding [GO:0017046]; pituitary adenylate cyclase-activating polypeptide receptor activity [GO:0001634]; vasoactive intestinal polypeptide receptor activity [GO:0004999] VFSNFYSK 1 1.8 0.9147 -0.39033 0 0 0 0 0 0 0 11.4896 0 0 0 0 P41594 GRM5_HUMAN Metabotropic glutamate receptor 5 (mGluR5) GRM5 GPRC1E MGLUR5 Homo sapiens (Human) "cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synapse organization [GO:0050808]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782] KGEVSCCWTCTPCK;LSIHINK;MVLLLILSVLLLKEDVR;NVPANFNEAK;SVCSEPCEK;TCNSSLTLK;VLLLILSVLLLK;VLLLILSVLLLKEDVR 8 5.4 0.98066 -1.626 5.69176 11.3782 0 11.0271 10.723 12.2015 0 0 0 0 9.11811 0 P41595 5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) HTR2B Homo sapiens (Human) "calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; heart morphogenesis [GO:0003007]; intestine smooth muscle contraction [GO:0014827]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; serotonin receptor signaling pathway [GO:0007210]; vasoconstriction [GO:0042310]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; G-protein alpha-subunit binding [GO:0001965]; Gq/11-coupled serotonin receptor activity [GO:0001587]; GTPase activator activity [GO:0005096]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] ITVVWLISIGIAIPVPIK;KDKALPNSGDETLMR 2 6.9 0.84707 -0.063465 4.00926 0 0 0 6.89797 0 0 0 0 0 0 0 P41597 CCR2_HUMAN C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192) CCR2 CMKBR2 Homo sapiens (Human) "blood vessel remodeling [GO:0001974]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular defense response [GO:0006968]; cellular homeostasis [GO:0019725]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; macrophage migration [GO:1905517]; monocyte chemotaxis [GO:0002548]; monocyte extravasation [GO:0035696]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of angiogenesis [GO:0016525]; negative regulation of eosinophil degranulation [GO:0043310]; negative regulation of type 2 immune response [GO:0002829]; neutrophil clearance [GO:0097350]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of astrocyte chemotaxis [GO:2000464]; positive regulation of CD8-positive, alpha-beta T cell extravasation [GO:2000451]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of inflammatory response [GO:0050727]; regulation of macrophage migration [GO:1905521]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell differentiation [GO:0045580]; regulation of vascular endothelial growth factor production [GO:0010574]; response to wounding [GO:0009611]; sensory perception of pain [GO:0019233]; T-helper 17 cell chemotaxis [GO:0035705]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; fibrillar center [GO:0001650]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR2 chemokine receptor binding [GO:0031727]; chemokine (C-C motif) ligand 12 binding [GO:0035716]; chemokine (C-C motif) ligand 2 binding [GO:0035715]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; identical protein binding [GO:0042802] MLSTSRSRFIR;TLLRCRNEK 2 5.3 0.76507 0.060586 0 0 0 0 0 0 0 0 0 0 0 8.78803 P41743 KPCI_HUMAN Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) PRKCI DXS1179E Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to chemical stress [GO:0062197]; cellular response to insulin stimulus [GO:0032869]; cytoskeleton organization [GO:0007010]; establishment of apical/basal cell polarity [GO:0035089]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; Golgi vesicle budding [GO:0048194]; intracellular signal transduction [GO:0035556]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; protein targeting to membrane [GO:0006612]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to interleukin-1 [GO:0070555]; secretion [GO:0046903]; vesicle-mediated transport [GO:0016192] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" AHCAICTDR;DMCSFDNEQLFTMK;GIIYRDLK 3 5.2 0.9521 -0.68054 0 0 0 0 0 0 0 0 6.98732 0 0 0 P41968 MC3R_HUMAN Melanocortin receptor 3 (MC3-R) MC3R Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; homoiothermy [GO:0042309]; locomotor rhythm [GO:0045475]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of blood pressure [GO:0008217]; regulation of feeding behavior [GO:0060259]; regulation of heart rate [GO:0002027]; regulation of metabolic process [GO:0019222]; sodium ion homeostasis [GO:0055078]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886] melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046] YVTIFYALRYHSIMTVR 1 5.3 0.82379 -0.018096 0 0 0 0 9.51789 0 0 0 0 0 0 0 P41970 ELK3_HUMAN ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) ELK3 NET SAP2 Homo sapiens (Human) angiogenesis [GO:0001525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; wound healing [GO:0042060] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MESAITLWQFLLQLLLDQK 1 4.7 0.78245 0.022671 0 0 0 0 0 0 0 0 0 0 10.8217 0 P42025 ACTY_HUMAN Beta-centractin (Actin-related protein 1B) (ARP1B) ACTR1B CTRN2 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524] AGFAGDQIPK;DWNDMERIWQYVYSK;ISAPQER;LAPKDIK;LLSEVKK 5 12.2 0.98103 -1.6256 0 10.6686 0 0 0 7.93198 0 9.49562 0 0 0 0 P42081 CD86_HUMAN T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86) CD86 CD28LG2 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295] cell surface [GO:0009986]; centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] EKFDSVHSKYMGR;MGLSNILFVMAFLLSGAAPLK;RPRNSYKCGTNTMER 3 15.2 0.95657 -0.99271 0 0 0 8.28207 0 0 0 8.29792 10.5611 0 0 0 P42126 ECI1_HUMAN "Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)" ECI1 DCI Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]" DADVQNFVSFISK;ILADNPR;LENDKSFR 3 9.3 0.92544 -0.45155 0 0 0 0 0 0 0 0 0 0 10.3984 0 P42127 ASIP_HUMAN Agouti-signaling protein (ASP) (Agouti switch protein) ASIP AGTI AGTIL ASP Homo sapiens (Human) adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; epigenetic programming in the zygotic pronuclei [GO:0044725]; generation of precursor metabolites and energy [GO:0006091]; hormone-mediated signaling pathway [GO:0009755]; melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; positive regulation of melanin biosynthetic process [GO:0048023]; signal transduction [GO:0007165] extracellular space [GO:0005615] melanocortin receptor binding [GO:0031779]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782] NSCKPPAPACCDPCASCQCRFFR 1 17.4 0.83451 -0.029624 0 0 0 4.35226 0 0 0 0 0 0 0 0 P42166 LAP2A_HUMAN "Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]" TMPO LAP2 Homo sapiens (Human) chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nucleus [GO:0005634] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; lamin binding [GO:0005521] EATQILSVPK;QNGSNDSDRYSDNEEGKK;SELVANNVTLPAGEQR;SSTPLPTISSSAENTR;YGVNPGPIVGTTR;YSDNEEGK;YSDNEEGKKK 7 10.7 0.97844 -2.1196 0 13.5048 7.55175 0 0 0 0 0 0 0 0 0 P42167 LAP2B_HUMAN "Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]" TMPO LAP2 Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] DNA binding [GO:0003677]; lamin binding [GO:0005521] QRRVEHNQVGEK;REPLKGR;SELVANNVTLPAGEQR;SSTPLPTISSSAENTR;YGVNPGPIVGTTR;YVPKYVPLADVKSEK;YVPLADVK 7 22.9 0.012048 0.83446 0 0 14.5983 0 6.77202 0 0 9.79792 0 11.4939 10.9528 9.52795 P42224 STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) STAT1 Homo sapiens (Human) blood circulation [GO:0008015]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; renal tubule development [GO:0061326]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to hydrogen peroxide [GO:0042542]; response to interferon-beta [GO:0035456]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to peptide hormone [GO:0043434]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333] axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; ISGF3 complex [GO:0070721]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] "cadherin binding [GO:0045296]; CCR5 chemokine receptor binding [GO:0031730]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]" ALLKDQQPGTFLLR;ILENAQR;TELISVSEVHPSR;TGVQFTVK;TGVQFTVKLRLLVK 5 6.4 0.95574 -0.98589 0 0 0 0 4.31114 0 11.4466 11.8489 11.7386 0 0 10.395 P42226 STAT6_HUMAN Signal transducer and activator of transcription 6 (IL-4 Stat) STAT6 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell proliferation [GO:0070666]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; T-helper 1 cell lineage commitment [GO:0002296] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]" FLLGLRFLGAPAKPPLVR;QILQGEKK 2 3.1 0.95462 -0.88544 0 0 0 0 8.76404 0 8.98025 7.7961 9.3229 0 0 0 P42229 STA5A_HUMAN Signal transducer and activator of transcription 5A STAT5A STAT5 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil differentiation [GO:0030222]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; lactation [GO:0007595]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell population proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; taurine metabolic process [GO:0019530]; thrombopoietin-mediated signaling pathway [GO:0038163] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FKAEVQSNRGLTK;QQTIILDDELIQWK 2 3.4 0.95849 -1.0107 0 0 0 0 10.1283 0 0 0 0 5.09119 0 0 P42261 GRIA1_HUMAN "Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1)" GRIA1 GLUA1 GLUH1 GLUR1 Homo sapiens (Human) "behavioral response to pain [GO:0048266]; cellular response to amine stimulus [GO:0071418]; cellular response to ammonium ion [GO:0071242]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to dsRNA [GO:0071359]; cellular response to L-glutamate [GO:1905232]; cellular response to peptide hormone stimulus [GO:0071375]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuronal action potential [GO:0019228]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of membrane potential [GO:0045838]; receptor internalization [GO:0031623]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of receptor recycling [GO:0001919]; response to arsenic-containing substance [GO:0046685]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to lithium ion [GO:0010226]; response to morphine [GO:0043278]; response to nutrient levels [GO:0031667]; response to psychosocial stress [GO:1990911]; response to sucrose [GO:0009744]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]" "AMPA glutamate receptor complex [GO:0032281]; axonal spine [GO:0044308]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; proximal dendrite [GO:1990635]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]" adenylate cyclase binding [GO:0008179]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; beta-2 adrenergic receptor binding [GO:0031698]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; glutamate receptor binding [GO:0035254]; glutamate-gated calcium ion channel activity [GO:0022849]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; myosin V binding [GO:0031489]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; PDZ domain binding [GO:0030165]; peptide hormone receptor binding [GO:0051428]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; small GTPase binding [GO:0031267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GSALRNPVNLAVLKLNEQGLLDK;VGGNLDSK 2 3.4 0.86558 -0.091958 0 0 0 0 0 0 0 0 0 6.82985 0 0 P42262 GRIA2_HUMAN "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2)" GRIA2 GluA2 GLUR2 Homo sapiens (Human) "chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; asymmetric synapse [GO:0032279]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic endocytic zone [GO:0098843] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic cation channel activity [GO:0099094]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GECGAKDSGSKEK;IGYWSEVDK;INYTINIMELKTNGPRK;NKWWYDKGECGAK;RINYTINIMELK;VGGNLDSK 6 6.2 0.97399 -1.4194 0 10.9623 0 0 0 0 12.2519 11.8216 9.47535 10.8454 8.85826 0 P42263 GRIA3_HUMAN "Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3)" GRIA3 GluA3 GLUR3 GLURC Homo sapiens (Human) "glutamate receptor signaling pathway [GO:0007215]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DVQEFRR;NKWWYDKGECGAK;VGGNLDSK;YLIDCEVERINTILEQVVILGKHSR 4 5.9 0.9098 -0.30032 0 0 6.22016 10.2866 0 0 0 0 0 0 0 0 P42285 MTREX_HUMAN Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) MTREX DOB1 KIAA0052 MTR4 SKIV2L2 Homo sapiens (Human) "DNA damage response [GO:0006974]; maturation of 5.8S rRNA [GO:0000460]; mRNA splicing, via spliceosome [GO:0000398]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]; snRNA catabolic process [GO:0016076]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ADAFGDELFSVFEGDSTTAAGTK;AIPGVVEKVK;LTEQLAGPLR;QFAEWICHLHK;TVLQMDELKCR;VIFTSPIKALSNQK 6 7.6 0 20.195 0 10.8623 8.63927 9.64519 0 0 0 0 7.65507 0 0 0 P42330 AK1C3_HUMAN "Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)" AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; cellular response to corticosteroid stimulus [GO:0071384]; cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to starvation [GO:0009267]; cyclooxygenase pathway [GO:0019371]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; macromolecule metabolic process [GO:0043170]; male gonad development [GO:0008584]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of testosterone biosynthetic process [GO:2000224]; renal absorption [GO:0070293]; response to nutrient [GO:0007584]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]; testosterone biosynthetic process [GO:0061370] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; Delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; geranylgeranyl reductase activity [GO:0045550]; ketoreductase activity [GO:0045703]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; prostaglandin D2 11-ketoreductase activity [GO:0036131]; prostaglandin F synthase activity [GO:0047017]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)+] activity [GO:0030283]" EDIFYTSK;GVVVLAK;LNDGHFMPVLGFGTYAPPEVPR;REDIFYTSK;TPALIALR 5 14.2 0.7836 0.019237 0 0 0 0 0 7.86505 7.33709 0 0 0 0 0 P42331 RHG25_HUMAN Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) ARHGAP25 KIAA0053 Homo sapiens (Human) "actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]" phagocytic cup [GO:0001891] GTPase activator activity [GO:0005096] FVFEIIPVFGQR;KEIETQKQMYEEQIK;QRSIVKNWQQR 3 6.3 0.95149 -0.70104 0 0 0 8.01363 0 0 8.58579 0 8.30127 8.32688 0 0 P42336 PK3CA_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)" PIK3CA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; anoikis [GO:0043276]; autosome genomic imprinting [GO:0141068]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle contraction [GO:0060048]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; epidermal growth factor receptor signaling pathway [GO:0007173]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet activation [GO:0030168]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TOR signaling [GO:0032008]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of multicellular organism growth [GO:0040014]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to L-leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; insulin receptor substrate binding [GO:0043560]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" DPLSEITEQEKDFLWSHR;FQEMCYK;IGHFFFWHLK;LCLSICSVKGRK;QDMLTLQIIRIMENIWQNQGLDLR;TEQEALEYFMK;TVSQRFGLLLESYCR 7 9.1 0.97458 -3.5367 12.3911 0 0 7.92665 0 0 0 11.5065 0 0 0 10.4882 P42338 PK3CB_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)" PIK3CB PIK3C1 Homo sapiens (Human) angiogenesis involved in wound healing [GO:0060055]; autophagy [GO:0006914]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; chemotaxis [GO:0006935]; embryonic cleavage [GO:0040016]; endocytosis [GO:0006897]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of autophagy [GO:0010508]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cell-matrix adhesion [GO:0001952]; regulation of clathrin-dependent endocytosis [GO:2000369]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; protein serine kinase activity [GO:0106310]" GSVGHMK;KFSEEKILSLVGLSWMDWLK;KQPYYYPPFDK;KTGQLFHIDFGHILGNFKSK;LKTLNSLIKLNAVK;LVTRSCDPGEK;SEEEALK 7 8.4 0.97518 -4.1084 9.12135 8.42744 0 0 0 10.4132 9.57295 0 0 0 0 12.0465 P42345 MTOR_HUMAN Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 Homo sapiens (Human) "'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; anoikis [GO:0043276]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to methionine [GO:0061431]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; oligodendrocyte differentiation [GO:0048709]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cytoplasmic translational initiation [GO:1904690]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glycolytic process [GO:0045821]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein destabilization [GO:0031648]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of locomotor rhythm [GO:1904059]; regulation of lysosome organization [GO:1905671]; regulation of macroautophagy [GO:0016241]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to amino acid [GO:0043200]; response to heat [GO:0009408]; response to nutrient levels [GO:0031667]; rhythmic process [GO:0048511]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; TORC2 signaling [GO:0038203]; voluntary musculoskeletal movement [GO:0050882]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156] DFAHKRQK;LIRPYMEPILKALILKLK;QKAMQVDATVFTCISMLAR 3 1.7 0.98058 -1.6765 0 0 0 7.07296 0 0 0 0 0 0 0 10.7217 P42356 PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) PI4KA PIK4 PIK4CA Homo sapiens (Human) modulation by host of viral process [GO:0044788]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; reorganization of cellular membranes to establish viral sites of replication [GO:0140754]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296] ALGHIAVALRDTPKVMEPILQILQQK;DIAIDNICR;DYSNFMASLNLRNR;EAKPRLQKLFR;EFNIPLEMLRELLNLVKK;FPHLLWSGTVLK;GFYFNTVLSLAR;GPALKASSSAGNLGVLIPVIAVLTRR;HRFSPNMTER;LFPKIPPHSLR;LYISQESDK;SFPPDAILFYIPQIVQALRYDKMGYVR;VQPGCYLPSNPEAIVLDIDYK 13 9.8 0.97605 -2.2554 0 2.40089 0 0 8.90421 9.25238 8.60503 9.32472 0 0 6.54811 13.4344 P42357 HUTH_HUMAN Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) HAL HIS Homo sapiens (Human) L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] cytosol [GO:0005829] histidine ammonia-lyase activity [GO:0004397] LTPTAEK;NKPDNGGFTSVDDAHFLVRR;SGWADAK;VQDAYTLR 4 6.4 0.95303 -0.7751 7.21461 10.8926 0 0 9.61021 0 0 0 0 0 12.0799 0 P42566 EPS15_HUMAN Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) EPS15 AF1P Homo sapiens (Human) clathrin coat assembly [GO:0048268]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; Golgi to endosome transport [GO:0006895]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein transport [GO:0015031]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cell population proliferation [GO:0042127]; symbiont entry into host cell [GO:0046718]; vesicle organization [GO:0016050] aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; clathrin coat of coated pit [GO:0030132]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; polyubiquitin modification-dependent protein binding [GO:0031593]; SH3 domain binding [GO:0017124] EEEQRLAR 1 0.9 0.97937 -1.5345 0 12.4658 0 0 0 0 0 0 0 0 0 0 P42568 AF9_HUMAN Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) MLLT3 AF9 YEATS3 Homo sapiens (Human) "anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of chromatin organization [GO:1902275]; regulation of stem cell division [GO:2000035]; segment specification [GO:0007379]" chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; molecular adaptor activity [GO:0060090] GPEHSNIQHFVEK 1 2.3 0.80934 0.0091627 0 0 0 0 0 0 0 0 0 10.1325 0 0 P42574 CASP3_HUMAN Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Homo sapiens (Human) anterior neural tube closure [GO:0061713]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to staurosporine [GO:0072734]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production [GO:0001818]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]; regulation of synaptic vesicle cycle [GO:0098693]; response to amino acid [GO:0043200]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; striated muscle cell differentiation [GO:0051146]; T cell homeostasis [GO:0043029] cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877] SLTGKPK 1 2.5 0.92874 -0.46062 0 12.3636 0 0 0 0 0 0 0 0 0 0 P42658 DPP6_HUMAN A-type potassium channel modulatory protein DPP6 (DPPX) (Dipeptidyl aminopeptidase-like protein 6) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI) DPP6 Homo sapiens (Human) protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236] LAYAAINDSR;MFDLETNEHVKK;QNEEPVFSK;SDGDEEDELVGSNPPQR 4 5.5 0.92924 -0.47008 0 3.54881 0 0 0 0 0 0 11.6537 0 0 6.46122 P42677 RS27_HUMAN Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) RPS27 MPS1 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]; translation at postsynapse [GO:0140242]; translation at presynapse [GO:0140236] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270] LVQSPNSYFMDVK 1 15.5 0.0048544 1.5745 0 10.3329 0 0 0 0 0 10.9074 0 10.3889 10.5436 0 P42679 MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) MATK CTK HYL Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] GQQQLLVSPRFLR 1 2.6 0.92354 -0.44906 0 0 0 0 0 0 0 0 0 0 0 6.24384 P42680 TEC_HUMAN Tyrosine-protein kinase Tec (EC 2.7.10.2) TEC PSCTK4 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of platelet activation [GO:0010543]; T cell receptor signaling pathway [GO:0050852]; tissue regeneration [GO:0042246] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipid binding [GO:0005543] ALPPAPETKKR;LAPGCEKYNLFESSIR;LGKWRAQYK;SMLTYYEGRAEK 4 7.6 0.9772 -2.2359 0 0 0 6.74174 0 0 0 0 0 7.10297 9.1689 8.6551 P42681 TXK_HUMAN Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) TXK PTK4 RLK Homo sapiens (Human) adaptive immune response [GO:0002250]; positive regulation of cytokine production [GO:0001819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] QESKEGAFIVRDSR 1 2.7 0.95367 -0.92792 0 0 0 0 0 0 0 0 0 0 0 11.6085 P42685 FRK_HUMAN Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) FRK PTK5 RAK Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] MSNICQRLWEYLEPYLPCLSTEADK;TSDGLCVK 2 6.5 0.91735 -0.42954 0 0 0 0 0 0 0 0 7.87227 0 0 8.27435 P42694 HELZ_HUMAN Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) HELZ DRHC KIAA0054 Homo sapiens (Human) regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] AEKSCEQACESLK;ALRLQHSGSTNK;DIEVASNPAFPQR;ELIAPPK;GEDVQEKNSTAFYNNAEVFEVVERVEELR;GPGRPLYQRR;IESLLYR;LLNTAITR;LVQTQGTKEK;TAQPRELIAPPK;TVKPPEDQLK;VLNVQGKQFRVLFLSTVR 12 7.3 0.97574 -5.0987 8.50391 0 4.46767 9.88286 0 0 0 13.3156 13.3092 10.9584 9.73818 9.88087 P42694 HELZ_HUMAN Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) HELZ DRHC KIAA0054 Homo sapiens (Human) regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] AEKSCEQACESLK;ALRLQHSGSTNK;GEDVQEKNSTAFYNNAEVFEVVERVEELR;IESLLYR;LLNTAITR;LVQTQGTKEK;VKPLLMKLKR;VLNVQGKQFRVLFLSTVR 8 9.2 0.87427 -0.1069 0 0 0 0 0 0 0 0 0 0 2.10806 0 P42695 CNDD3_HUMAN Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) NCAPD3 CAPD3 KIAA0056 Homo sapiens (Human) cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]" histone binding [GO:0042393]; methylated histone binding [GO:0035064] DLLMEEDDMALANVVMQEAQK;EIKLLAMR;IPALRELMHYLR;NAIFHLLKNFLRLLPK;NFIENIIPIIISLKTVLEK;NFLRLLPKFSLK;QALQSLTELLMAQPR;YIPNISMCLK 8 7 0.98104 -1.7386 11.3933 7.20555 8.82944 7.97304 7.37608 0 13.4331 0 0 0 0 11.9667 P42696 RBM34_HUMAN RNA-binding protein 34 (RNA-binding motif protein 34) RBM34 KIAA0117 Homo sapiens (Human) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] GEHHSRGGTGR;LRVMRSVNK;SVQEGENPDDGVR;TAEGHPK;TVFVGNLPVTCNKK 5 12.6 0.9777 -1.9529 0 0 0 7.79682 10.0662 7.9318 8.56605 0 9.49893 7.88013 6.90123 0 P42701 I12R1_HUMAN Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212) IL12RB1 IL12R IL12RB Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] EYVVRCR;FSVEQLGQDGR;LQLHMLSCPCKAKATR 3 5.1 0.97622 -2.2957 0 0 0 0 0 0 0 0 0 0 6.13147 10.4829 P42702 LIFR_HUMAN Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) LIFR Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; leukemia inhibitory factor signaling pathway [GO:0048861]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; leukemia inhibitory factor receptor activity [GO:0004923] CSTETFWKWSK;DINSTAVK;INFLCEIEIKK 3 2.7 0.95901 -1.0087 0 0 9.0555 0 9.35078 0 0 0 0 0 0 0 P42704 LPPRC_HUMAN "Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)" LRPPRC LRP130 Homo sapiens (Human) autophagy [GO:0006914]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion transport along microtubule [GO:0047497]; mRNA transport [GO:0051028]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; regulation of mitochondrial translation [GO:0070129] condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904] beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] AGYPQYVSEILEKVTCER;CVANNQVETLEKLVELTQKLFECDR;EVQMHSFPLQFTLHCALLANK;GDVENIEVVQK;IQEENVIPR;KVIEEQLEPAVEKISIMAER;LDDLFLKRYASLLK;MEEANIQPNR;MNVKIPENIYR;TVLDQQQTPSR;VYLQNEYK 11 11.3 0 8.7312 10.5004 11.7756 0 9.25484 11.1911 6.43139 0 10.459 3.16176 0 0 0 P42765 THIM_HUMAN "3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)" ACAA2 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; cholesterol biosynthetic process [GO:0006695]; fatty acid beta-oxidation [GO:0006635]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA hydrolase activity [GO:0003986]; fatty acyl-CoA hydrolase activity [GO:0047617]; RNA binding [GO:0003723] SLDLDISK;VSPETVDSVIMGNVLQSSSDAIYLAR 2 8.6 0.76364 0.068346 9.36492 0 9.43154 0 0 5.96357 0 0 0 0 0 0 P42766 RL35_HUMAN Large ribosomal subunit protein uL29 (60S ribosomal protein L35) RPL35 Homo sapiens (Human) "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VLTVINQTQK;VLTVINQTQKENLR 2 11.4 0 7.047 0 0 12.7562 0 0 0 10.8705 10.2057 0 0 11.4398 0 P42768 WASP_HUMAN Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) WAS IMD2 Homo sapiens (Human) actin filament polymerization [GO:0030041]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; blood coagulation [GO:0007596]; Cdc42 protein signal transduction [GO:0032488]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; endosomal transport [GO:0016197]; epidermis development [GO:0008544]; immune response [GO:0006955]; negative regulation of cell motility [GO:2000146]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of lamellipodium assembly [GO:0010591]; regulation of stress fiber assembly [GO:0051492]; regulation of T cell antigen processing and presentation [GO:0002625]; T cell activation [GO:0042110] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; vesicle membrane [GO:0012506] actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] AIHSSDEGEDQAGDEDEDDEWDD;GPPPPGR;LFEMLGR;RSRAIHSSDEGEDQAGDEDEDDEWDD 4 8 0.87658 -0.13392 0 5.68636 0 0 0 0 4.39561 0 0 8.80497 0 0 P42771 CDN2A_HUMAN Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A) CDKN2A CDKN2 MTS1 Homo sapiens (Human) cellular senescence [GO:0090398]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphorylation [GO:0042326]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; replicative senescence [GO:0090399] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; senescence-associated heterochromatin focus [GO:0035985] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] AAAGGTR;LDVRDAWGR;YLRAAAGGTR 3 12.2 0.98072 -1.6743 0 0 0 0 0 10.724 0 11.9307 0 0 0 0 P42772 CDN2B_HUMAN Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) CDKN2B MTS2 Homo sapiens (Human) cellular response to cell-matrix adhesion [GO:0071460]; cellular response to nutrient [GO:0031670]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; liver development [GO:0001889]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of phosphorylation [GO:0042326]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to cytokine [GO:0034097]; response to organic cyclic compound [GO:0014070]; spleen development [GO:0048536] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901] GMPSGGGSDEGLASAAARGLVEK;LDVRDAWGR 2 23.2 0.83404 -0.029624 0 7.52888 0 0 0 0 0 0 0 0 0 0 P42773 CDN2C_HUMAN Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) CDKN2C CDKN6 Homo sapiens (Human) negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphorylation [GO:0042326]; negative regulation of stem cell proliferation [GO:2000647]; oligodendrocyte differentiation [GO:0048709]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901] GANPDLK 1 4.2 0.64018 0.1734 0 0 0 0 0 0 0 0 6.97831 8.65564 0 0 P42830 CXCL5_HUMAN C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)] CXCL5 ENA78 SCYB5 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; identical protein binding [GO:0042802] MSLLSSR 1 6.1 0.91012 -0.31005 0 0 0 8.24598 0 0 0 8.45841 0 0 0 0 P42857 NSG1_HUMAN Neuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1) NSG1 D4S234 NEEP21 Homo sapiens (Human) "amyloid precursor protein metabolic process [GO:0042982]; apoptotic process [GO:0006915]; clathrin coat assembly [GO:0048268]; endosomal transport [GO:0016197]; neurotransmitter receptor cycle [GO:0099627]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor cycle [GO:0099630]; receptor recycling [GO:0001881]; regulation of long-term synaptic potentiation [GO:1900271]; spontaneous synaptic transmission [GO:0098814]; vesicle-mediated transport in synapse [GO:0099003]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi cisterna membrane [GO:0032580]; late endosome [GO:0005770]; lateral plasma membrane [GO:0016328]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; multivesicular body membrane [GO:0032585]; nucleus [GO:0005634]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; somatodendritic compartment [GO:0036477]; trans-Golgi network membrane [GO:0032588] clathrin light chain binding [GO:0032051]; ionotropic glutamate receptor binding [GO:0035255] LSEQETEAAEK 1 5.9 0.93641 -0.55904 0 0 0 0 9.33945 0 0 0 0 0 0 0 P42858 HD_HUMAN "Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]" HTT HD IT15 Homo sapiens (Human) "apoptotic process [GO:0006915]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; microtubule-based transport [GO:0099111]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of aggrephagy [GO:1905337]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CAMKK-AMPK signaling cascade [GO:1905291]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of lipophagy [GO:1904504]; positive regulation of mitophagy [GO:1901526]; protein destabilization [GO:0031648]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle transport along microtubule [GO:0047496]; vocal learning [GO:0042297]" autophagosome [GO:0005776]; axon [GO:0030424]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991] beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; p53 binding [GO:0002039]; phosphoprotein phosphatase activity [GO:0004721]; profilin binding [GO:0005522]; transmembrane transporter binding [GO:0044325] ALALSCVGAAVALHPESFFSK;ITAAATRLFR;QIADIILPMLAK;VTLDLQNSTEK 4 1.7 0.97319 -2.499 0 0 0 0 9.8993 0 0 14.6719 14.759 0 13.6743 13.5015 P42892 ECE1_HUMAN Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Homo sapiens (Human) axonogenesis involved in innervation [GO:0060385]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492] early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] DNFQDTLQVVTAHYR;VTADQLR 2 2.9 0.94103 -0.60777 0 0 0 0 0 0 0 0 0 0 0 10.4976 P42898 MTHR_HUMAN Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53) MTHFR Homo sapiens (Human) heterochromatin organization [GO:0070828]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; response to amino acid [GO:0043200]; response to folic acid [GO:0051593]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to vitamin B2 [GO:0033274]; response to xenobiotic stimulus [GO:0009410]; S-adenosylmethionine metabolic process [GO:0046500]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]; modified amino acid binding [GO:0072341]; NADP binding [GO:0050661]; protein-containing complex binding [GO:0044877] AYLEFFTSRETAEALLQVLK;LEVPQEIKDVIEPIK 2 5.3 0.95554 -0.87253 6.01634 5.80903 0 0 0 7.59291 0 8.29016 0 0 0 0 P43004 EAA2_HUMAN Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) SLC1A2 EAAT2 GLT1 Homo sapiens (Human) adult behavior [GO:0030534]; cellular response to cocaine [GO:0071314]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; neurotransmitter reuptake [GO:0098810]; neurotransmitter transport [GO:0006836]; positive regulation of D-glucose import [GO:0046326]; protein homotrimerization [GO:0070207]; response to amino acid [GO:0043200]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; telencephalon development [GO:0021537]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; visual behavior [GO:0007632] astrocyte projection [GO:0097449]; axolemma [GO:0030673]; cell body [GO:0044297]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982] cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175] LVIMIMWYSPLGIACLICGK 1 3.5 0.78441 0.029876 11.5082 0 0 0 0 0 0 0 0 0 0 0 P43005 EAA3_HUMAN Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 HEAAC1 Homo sapiens (Human) adult behavior [GO:0030534]; behavioral fear response [GO:0001662]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to ammonium ion [GO:0071242]; cellular response to bisphenol A [GO:1903926]; cellular response to cocaine [GO:0071314]; cellular response to mercury ion [GO:0071288]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; conditioned place preference [GO:1990708]; cysteine transport [GO:0042883]; cytokine-mediated signaling pathway [GO:0019221]; D-aspartate import across plasma membrane [GO:0070779]; D-aspartate transmembrane transport [GO:0070777]; dopamine metabolic process [GO:0042417]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; gene expression [GO:0010467]; glutamate receptor signaling pathway [GO:0007215]; glutathione biosynthetic process [GO:0006750]; grooming behavior [GO:0007625]; heart contraction [GO:0060047]; intracellular glutamate homeostasis [GO:0090461]; intracellular zinc ion homeostasis [GO:0006882]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neurotransmitter receptor transport to plasma membrane [GO:0098877]; neurotransmitter transport [GO:0006836]; positive regulation of heart rate [GO:0010460]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of protein targeting to membrane [GO:0090313]; response to amphetamine [GO:0001975]; response to anesthetic [GO:0072347]; response to axon injury [GO:0048678]; response to decreased oxygen levels [GO:0036293]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; righting reflex [GO:0060013]; superoxide metabolic process [GO:0006801]; synapse organization [GO:0050808]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; zinc ion transmembrane transport [GO:0071577] apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; distal dendrite [GO:0150002]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proximal dendrite [GO:1990635]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083] chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; D-aspartate transmembrane transporter activity [GO:0140010]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion channel activity [GO:0005253] IIEVEDWEIFRK 1 2.3 0.039783 0.52547 12.3905 0 0 0 0 0 0 10.8827 10.997 9.59904 0 0 P43007 SATT_HUMAN Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) SLC1A4 ASCT1 SATT Homo sapiens (Human) "amino acid transport [GO:0006865]; cognition [GO:0050890]; glutamine transport [GO:0006868]; hydroxyproline transport [GO:0034589]; L-alanine import across plasma membrane [GO:1904273]; L-alanine transport [GO:0015808]; L-aspartate import across plasma membrane [GO:0140009]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; proline transport [GO:0015824]; synaptic transmission, glutamatergic [GO:0035249]; threonine transport [GO:0015826]; transport across blood-brain barrier [GO:0150104]" cell surface [GO:0009986]; centrosome [GO:0005813]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; melanosome [GO:0042470]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] amino acid transmembrane transporter activity [GO:0015171]; chloride channel activity [GO:0005254]; L-alanine transmembrane transporter activity [GO:0015180]; L-aspartate transmembrane transporter activity [GO:0015183]; L-cystine transmembrane transporter activity [GO:0015184]; L-glutamine transmembrane transporter activity [GO:0015186]; L-hydroxyproline transmembrane transporter activity [GO:0034590]; L-proline transmembrane transporter activity [GO:0015193]; L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; symporter activity [GO:0015293] NILGLVLFALVLGVALKK 1 7.7 0.34122 0.2397 0 5.08223 0 0 0 0 0 0 0 0 0 7.95878 P43026 GDF5_HUMAN Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin) GDF5 BMP14 CDMP1 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cell-cell signaling [GO:0007267]; chondroblast differentiation [GO:0060591]; chondrocyte differentiation [GO:0002062]; embryonic limb morphogenesis [GO:0030326]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of neuron apoptotic process [GO:0043524]; ossification involved in bone remodeling [GO:0043932]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of multicellular organism growth [GO:0040014]; response to mechanical stimulus [GO:0009612]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] BMP binding [GO:0036122]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802] AVDLRGLGFDRAAR;GGTGQTGGLTQPK;NVFRPGGHSYGGGATNANARAK 3 9.8 0.95346 -0.7328 0 6.95128 0 0 0 0 0 0 0 0 9.16654 0 P43034 LIS1_HUMAN Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) PAFAH1B1 LIS1 MDCR MDS PAFAHA Homo sapiens (Human) acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; auditory receptor cell development [GO:0060117]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; corpus callosum morphogenesis [GO:0021540]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity of embryonic epithelium [GO:0042249]; germ cell development [GO:0007281]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; JNK cascade [GO:0007254]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; maintenance of centrosome location [GO:0051661]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; microtubule organizing center organization [GO:0031023]; microtubule sliding [GO:0051012]; microtubule-based process [GO:0007017]; modulation of chemical synaptic transmission [GO:0050804]; myeloid leukocyte migration [GO:0097529]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of embryonic development [GO:0040019]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde axonal transport [GO:0008090]; stem cell division [GO:0017145]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496] 1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; astral microtubule [GO:0000235]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; Schaffer collateral - CA1 synapse [GO:0098685]; stereocilium [GO:0032420] dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982] TLRVWDYKNK;VLSQRQRDELNR 2 5.4 0.96743 -1.297 0 0 0 0 0 0 0 0 0 11.0922 10.4623 4.70752 P43080 GUC1A_HUMAN Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A) GUCA1A C6orf131 GCAP GCAP1 GUCA1 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; phototransduction [GO:0007602]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of guanylate cyclase activity [GO:0031284]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; guanylate cyclase regulator activity [GO:0030249] SVEELSSTECHQWYKK 1 8 0.57111 0.18165 0 0 0 0 0 0 0 0 0 0 8.55608 0 P43088 PF2R_HUMAN Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor) PTGFR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; parturition [GO:0007567]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] prostaglandin F receptor activity [GO:0004958] IQASRTWCFYNTEDIK 1 4.5 0.91526 -0.4342 0 0 0 0 8.37173 0 0 0 0 0 0 0 P43115 PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) PTGER3 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell death [GO:0008219]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fever generation [GO:0031622] membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] THTEKQKECNFFLIAVR 1 4.4 0.8541 -0.08043 0 0 0 0 0 0 0 0 0 5.45174 0 0 P43121 MUC18_HUMAN Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) MCAM MUC18 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; glomerular filtration [GO:0003094]; positive regulation of cell migration [GO:0030335]; vascular wound healing [GO:0061042] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] EAEEETTNDNGVLVLEPAR;RAPGDQGEK;VSPAAPER 3 5.6 0.98058 -1.6588 0 0 0 0 0 0 0 0 0 8.04985 0 0 P43146 DCC_HUMAN Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) DCC IGDCC1 Homo sapiens (Human) anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; neuron migration [GO:0001764]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965] axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] transmembrane signaling receptor activity [GO:0004888] ATHSAGK;DVVPVLVSSRFVR 2 1.4 0.83665 -0.0354 0 0 11.1383 0 0 0 0 0 0 0 0 6.86456 P43166 CAH7_HUMAN Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) CA7 Homo sapiens (Human) "neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]" cytoplasm [GO:0005737]; cytosol [GO:0005829] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] QFHFHWGK 1 3 0.87855 -0.14057 0 0 0 8.76338 0 8.78398 0 0 0 0 13.66 0 P43220 GLP1R_HUMAN Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) GLP1R Homo sapiens (Human) "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; hormone secretion [GO:0046879]; learning or memory [GO:0007611]; negative regulation of blood pressure [GO:0045776]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; post-translational protein targeting to membrane, translocation [GO:0031204]; regulation of heart contraction [GO:0008016]; response to psychosocial stress [GO:1990911]" membrane [GO:0016020]; plasma membrane [GO:0005886] glucagon receptor activity [GO:0004967]; glucagon-like peptide 1 receptor activity [GO:0044508]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888] ALSVFIK;LPILFAIGVNFLIFVRVICIVVSKLK;WRLEHLHIQR;YLYEDEGCWTR 4 11.7 0.93303 -0.50759 0 14.2972 14.2202 0 4.0648 0 0 3.4034 0 0 0 7.91283 P43234 CATO_HUMAN Cathepsin O (EC 3.4.22.42) CTSO CTSO1 Homo sapiens (Human) proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] extracellular space [GO:0005615]; lysosome [GO:0005764] cysteine-type endopeptidase activity [GO:0004197] GYSAYDFSDQEDEMAK 1 5 0.64121 0.17286 0 0 0 0 0 0 0 0 0 0 4.59801 0 P43235 CATK_HUMAN Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) CTSK CTSO CTSO2 Homo sapiens (Human) bone resorption [GO:0045453]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; intramembranous ossification [GO:0001957]; mitophagy [GO:0000423]; mononuclear cell differentiation [GO:1903131]; negative regulation of cartilage development [GO:0061037]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252] GNKHWIIK;GYVTPVK 2 4.6 0.95436 -0.93002 0 0 0 0 0 7.63234 0 0 0 0 0 0 P43243 MATR3_HUMAN Matrin-3 MATR3 KIAA0723 Homo sapiens (Human) activation of innate immune response [GO:0002218]; blastocyst formation [GO:0001825]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; post-transcriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281] membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleus [GO:0005634] identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] FDSEYER;GAPPSSNIEDFHGLLPK;GNLGAGNGNLQGPR;GPGPLQER;GPGPLQERSLFEK;IGPYQPNVPVGIDYVIPK;IKKPEGKPDQKFDQK;LAEPYGK;SFQQSSLSR;SKSFQQSSLSRDSQGHGR;SQESGYYDR;TEEGPTLSYGR 12 15.2 0 6.3041 12.708 10.4777 14.8179 0 10.1464 13.0481 0 9.63083 8.2054 12.0646 12.6872 10.5084 P43246 MSH2_HUMAN DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) MSH2 Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell mediated immunity [GO:0019724]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; male gonad development [GO:0008584]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; negative regulation of neuron apoptotic process [GO:0043524]; oxidative phosphorylation [GO:0006119]; positive regulation of helicase activity [GO:0051096]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; postreplication repair [GO:0006301]; protein localization to chromatin [GO:0071168]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; somatic recombination of immunoglobulin genes involved in immune response [GO:0002204] "chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; MutSalpha complex [GO:0032301]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; guanine/thymine mispair binding [GO:0032137]; protein homodimerization activity [GO:0042803]" MGPAGAK;NFSTVDIQK;NKTEYEEAQDAIVK;NLQSVVLSK;QMPFTEMSEENITIK;QPLMDKNRIEER;QTLQEDLLRRFPDLNR 7 9.4 0.97254 -2.8123 0 11.4459 0 0 0 9.1227 12.9155 0 0 6.37638 10.4791 0 P43250 GRK6_HUMAN G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) GRK6 GPRK6 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703] DLKPENILLDDHGHIR 1 2.8 0.89655 -0.24533 0 0 0 0 0 0 0 0 0 0 0 11.8231 P43304 GPDM_HUMAN "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD)" GPD2 Homo sapiens (Human) glycerol catabolic process [GO:0019563]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophosphate shuttle [GO:0006127] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] SEQLTDRSEISLLPSDIDRYK;VRVSGAR 2 3.9 0.95408 -0.92255 0 0 8.64288 0 0 0 11.2363 0 0 0 0 0 P43307 SSRA_HUMAN Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 TRAPA PSEC0262 Homo sapiens (Human) cotranslational protein targeting to membrane [GO:0006613]; positive regulation of cell population proliferation [GO:0008284] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] FLVGFTNK;LLPRLLLLLLLVFPATVLFRGGPR;RLLPRLLLLLLLVFPATVLFR 3 11.5 0.8962 -0.24985 0 0 0 0 0 0 5.71562 0 0 8.13802 4.38121 5.57936 P43353 AL3B1_HUMAN Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.28) (EC 1.2.1.5) (EC 1.2.1.7) (Aldehyde dehydrogenase 7) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) (Medium-chain fatty aldehyde dehydrogenase) ALDH3B1 ALDH7 Homo sapiens (Human) alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; aldehyde metabolic process [GO:0006081]; cellular response to oxidative stress [GO:0034599]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; response to oxidative stress [GO:0006979]; sphingolipid catabolic process [GO:0030149] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; vesicle [GO:0031982] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; benzaldehyde dehydrogenase (NADP+) activity [GO:0018477]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814] ALLGCGRVAIGGQSDESDR 1 4.1 0.94505 -0.65007 9.94445 0 0 0 0 0 0 0 0 0 0 0 P43354 NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) NR4A2 NOT NURR1 TINUR Homo sapiens (Human) adult locomotory behavior [GO:0008344]; canonical Wnt signaling pathway [GO:0060070]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to oxidative stress [GO:0034599]; central nervous system neuron differentiation [GO:0021953]; central nervous system projection neuron axonogenesis [GO:0021952]; DNA-templated transcription [GO:0006351]; dopamine biosynthetic process [GO:0042416]; dopaminergic neuron differentiation [GO:0071542]; fat cell differentiation [GO:0045444]; general adaptation syndrome [GO:0051866]; habenula development [GO:0021986]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of dopamine metabolic process [GO:0042053]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" ADQDLLFESAFLELFVLRLAYR;CLAVGMVKEVVR;LSLFSFK 3 6.9 0.95149 -0.6882 0 0 10.7042 0 0 0 0 12.1475 0 0 0 0 P43355 MAGA1_HUMAN Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen) MAGEA1 MAGE1 MAGE1A Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] histone deacetylase binding [GO:0042826] AVITKKVADLVGFLLLK 1 5.5 0.86505 -0.087915 0 0 0 0 4.31317 0 0 0 0 0 0 0 P43357 MAGA3_HUMAN Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen) MAGEA3 MAGE3 Homo sapiens (Human) negative regulation of autophagy [GO:0010507]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of protein processing [GO:0010955]; negative regulation of transcription by RNA polymerase II [GO:0000122] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] caspase binding [GO:0089720]; histone deacetylase binding [GO:0042826] EGDCAPEEK;VAELVHFLLLKYRAR;VLHHMVK 3 9.9 0.85999 -0.081818 0 0 0 0 0 0 0 0 8.85003 0 0 0 P43360 MAGA6_HUMAN Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen) MAGEA6 MAGE6 Homo sapiens (Human) negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] EGDCAPEEK;KVAKLVHFLLLK;TGFLIIILAIIAK;VLHHMVK 4 13.1 0.95362 -0.78387 5.44751 0 0 0 4.78592 3.74481 0 0 3.73952 3.70221 2.71141 0 P43361 MAGA8_HUMAN Melanoma-associated antigen 8 (Cancer/testis antigen 1.8) (CT1.8) (MAGE-8 antigen) MAGEA8 MAGE8 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] YQIKEPVTK 1 2.8 0.93641 -0.52522 0 0 0 0 0 0 0 0 0 10.1693 0 0 P43362 MAGA9_HUMAN Melanoma-associated antigen 9 (Cancer/testis antigen 1.9) (CT1.9) (MAGE-9 antigen) MAGEA9 MAGE9 MAGEA9A; MAGEA9B Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] AALLIIVLGVILTK 1 4.4 0.69243 0.16227 0 0 0 0 0 0 0 0 0 0 5.55133 0 P43365 MAGAC_HUMAN Melanoma-associated antigen 12 (Cancer/testis antigen 1.12) (CT1.12) (MAGE-12 antigen) (MAGE12F antigen) MAGEA12 MAGE12 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] EGDCAPEEK;KLLTQDLVQENYLEYR;MAELVHFLLLKYRAR;TGLLIIVLAIIAK 4 16.9 0.60164 0.17693 0 0 2.53583 0 0 0 0 3.78293 0 7.68979 0 0 P43366 MAGB1_HUMAN Melanoma-associated antigen B1 (Cancer/testis antigen 3.1) (CT3.1) (DSS-AHC critical interval MAGE superfamily 10) (DAM10) (MAGE-B1 antigen) (MAGE-XP antigen) MAGEB1 MAGEL1 MAGEXP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] VLEFLAKMNGATPR 1 4 0.92238 -0.44093 0 0 0 0 0 0 0 0 0 0 0 11.1956 P43378 PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) PTPN9 Homo sapiens (Human) negative regulation of neuron projection development [GO:0010977]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" VLIVGAPIWFRVPYSIISLLLK;VLNLLKGAFPARLK;VPYSIISLLLKDK 3 6.4 0.98011 -2.0094 6.54066 11.0301 0 0 0 0 0 0 0 0 6.24033 0 P43403 ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) ZAP70 SRK Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; beta selection [GO:0043366]; calcium-mediated signaling [GO:0019722]; cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative thymic T cell selection [GO:0045060]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell differentiation [GO:0045582]; positive thymic T cell selection [GO:0045059]; protein phosphorylation [GO:0006468]; T cell activation [GO:0042110]; T cell aggregation [GO:0070489]; T cell differentiation [GO:0030217]; T cell migration [GO:0072678]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] GPEVMAFIEQGK;MPWYHSSLTR;VEGPPGSTQK;WEDRPDFLTVEQRMR 4 7.6 0.97931 -1.8959 0 0 9.3861 0 0 0 0 0 0 0 10.8009 0 P43405 KSYK_HUMAN Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) SYK Homo sapiens (Human) adaptive immune response [GO:0002250]; amyloid-beta clearance [GO:0097242]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic signaling pathway [GO:0097190]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; beta selection [GO:0043366]; blood vessel morphogenesis [GO:0048514]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell differentiation [GO:0030154]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amyloid-beta [GO:1904646]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to molecule of fungal origin [GO:0071226]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; gamma-delta T cell differentiation [GO:0042492]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-3-mediated signaling pathway [GO:0038156]; intracellular signal transduction [GO:0035556]; leukocyte activation involved in immune response [GO:0002366]; leukocyte cell-cell adhesion [GO:0007159]; leukotriene biosynthetic process [GO:0019370]; lymph vessel development [GO:0001945]; macrophage activation involved in immune response [GO:0002281]; mast cell degranulation [GO:0043303]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-3 production [GO:0032752]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of arachidonate secretion [GO:0090237]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neutrophil degranulation [GO:0043313]; regulation of phagocytosis [GO:0050764]; regulation of platelet activation [GO:0010543]; regulation of platelet aggregation [GO:0090330]; regulation of superoxide anion generation [GO:0032928]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; serotonin secretion by platelet [GO:0002554]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] B cell receptor complex [GO:0019815]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early phagosome [GO:0032009]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T cell receptor complex [GO:0042101] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; integrin binding [GO:0005178]; interleukin-15 receptor binding [GO:0016170]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatase binding [GO:0019902]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; Toll-like receptor binding [GO:0035325] EVYLDRKLLTLEDK;LIATTAHEKMPWFHGK;NYYYDVVN;VVKTVAVKILK 4 7.7 0.97809 -2.139 3.37962 0 0 9.35074 0 7.99039 0 0 0 0 0 0 P43487 RANG_HUMAN Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Homo sapiens (Human) nucleocytoplasmic transport [GO:0006913]; positive regulation of mitotic centrosome separation [GO:0046604]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634] cadherin binding [GO:0045296]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] FLNAENAQK;LEALSVK 2 8 0.0086957 1.0492 0 0 9.99915 0 0 0 0 0 0 11.8659 12.0331 0 P43490 NAMPT_HUMAN Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) NAMPT PBEF PBEF1 Homo sapiens (Human) cell-cell signaling [GO:0007267]; circadian regulation of gene expression [GO:0032922]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD biosynthetic process [GO:0009435]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607] cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; nicotinamide phosphoribosyltransferase activity [GO:0047280] AVPEGFVIPR;KFPVTENSK;QYPPNTSKVYSYFECR 3 7.1 0.95403 -0.91959 11.2755 0 0 8.56308 0 0 0 0 11.4088 8.76298 0 0 P43626 KI2L1_HUMAN Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a) KIR2DL1 CD158A NKAT1 Homo sapiens (Human) immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell inhibitory signaling pathway [GO:0002769] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] LIGEHHDGVSK 1 3.2 0.93614 -0.52001 0 0 0 0 0 9.15939 0 0 0 0 0 0 P43628 KI2L3_HUMAN Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2) KIR2DL3 CD158B2 KIRCL23 NKAT2 Homo sapiens (Human) immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764] membrane [GO:0016020]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] HLHVLIGTSVVIILFILLLFFLLHR 1 7.3 0.71218 0.15167 0 3.39122 0 0 0 0 0 0 0 0 0 0 P43629 KI3L1_HUMAN Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e) KIR3DL1 CD158E NKAT3 NKB1 Homo sapiens (Human) immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell mediated cytotoxicity [GO:0042267] plasma membrane [GO:0005886] HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; molecular adaptor activity [GO:0060090] AGPHMGNHR 1 2.6 0.91749 -0.4011 0 0 0 11.6632 11.8686 0 0 0 12.9969 0 0 13.028 P43652 AFAM_HUMAN Afamin (Alpha-albumin) (Alpha-Alb) AFM ALB2 ALBA Homo sapiens (Human) protein stabilization [GO:0050821]; protein transport within extracellular region [GO:0071693]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] vitamin E binding [GO:0008431] DLSLREGK;LLKLTGFIFFLFFLTESLTLPTQPR;LVKDMVEYKDR;NCCNTENPPGCYRYAEDK;YAEDKFNETTEK;YAEDKFNETTEKSLK 6 12 0.97844 -1.9243 12.6705 7.90008 10.5475 0 0 0 0 4.43689 9.82474 6.17477 0 0 P43657 LPAR6_HUMAN Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor) LPAR6 P2RY5 Homo sapiens (Human) blastocyst hatching [GO:0001835]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] lysophosphatidic acid receptor activity [GO:0070915] INKTKVLK 1 2.3 0.97775 -1.5135 0 0 0 0 0 10.5627 0 0 0 0 0 0 P43681 ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 NACRA4 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; action potential [GO:0001508]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; DNA repair [GO:0006281]; inhibitory postsynaptic potential [GO:0060080]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; nervous system process [GO:0050877]; regulation of dopamine secretion [GO:0014059]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] LLPPLLLLLGTGLLR 1 2.4 0.66056 0.16903 0 5.39695 0 0 0 0 0 0 0 0 0 0 P43699 NKX21_HUMAN Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) NKX2-1 NKX2A TITF1 TTF1 Homo sapiens (Human) anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebral cortex cell migration [GO:0021795]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; club cell differentiation [GO:0060486]; developmental induction [GO:0031128]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain neuron fate commitment [GO:0021877]; gene expression [GO:0010467]; globus pallidus development [GO:0021759]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; interneuron migration [GO:1904936]; Leydig cell differentiation [GO:0033327]; locomotory behavior [GO:0007626]; lung development [GO:0030324]; lung saccule development [GO:0060430]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; oligodendrocyte differentiation [GO:0048709]; phospholipid metabolic process [GO:0006644]; pituitary gland development [GO:0021983]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; rhythmic process [GO:0048511]; thyroid gland development [GO:0030878]; type II pneumocyte differentiation [GO:0060510] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" IMSMSPK;SSPGRLSRR 2 4 0.97995 -1.8392 0 4.46741 0 8.11879 0 0 0 7.9357 0 0 0 12.5671 P45378 TNNT3_HUMAN "Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)" TNNT3 Homo sapiens (Human) positive regulation of calcium-dependent ATPase activity [GO:1903612]; regulation of ATP-dependent activity [GO:0043462]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009] cytosol [GO:0005829]; troponin complex [GO:0005861] calcium-dependent protein binding [GO:0048306]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013] AGTPAKGK;ERERQNR;ILAERRKPLNIDHLGEDK 3 12.3 0.88066 -0.15368 0 8.0881 0 0 0 9.12479 0 0 0 0 0 0 P45379 TNNT2_HUMAN "Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)" TNNT2 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; muscle filament sliding [GO:0030049]; negative regulation of ATP-dependent activity [GO:0032780]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; troponin complex [GO:0005861] actin binding [GO:0003779]; identical protein binding [GO:0042802]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013] QNRLAEERAR;TERKSGK 2 6.7 0.96672 -1.3005 0 0 0 0 0 0 0 0 0 0 10.1764 10.341 P45381 ACY2_HUMAN Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2) ASPA ACY2 ASP Homo sapiens (Human) acetate metabolic process [GO:0006083]; aspartate metabolic process [GO:0006531]; central nervous system myelination [GO:0022010]; positive regulation of oligodendrocyte differentiation [GO:0048714] cytosol [GO:0005829]; nucleus [GO:0005634] "aspartoacylase activity [GO:0019807]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" YIDCDLNR 1 2.6 0.914 -0.39033 0 0 0 0 0 0 0 0 0 0 9.163 0 P45844 ABCG1_HUMAN ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog) ABCG1 ABC8 WHT1 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol metabolic process [GO:0090181]; response to lipid [GO:0033993]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] ABC-type sterol transporter activity [GO:0034041]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; toxin transmembrane transporter activity [GO:0019534] AAVNIEFR;EGMCDSDHK;ITSHIGIGLLIGLLYLGIGNEAKK;LIAYFVLRYKIR;VCNLVPYLR 5 9.1 0.95875 -1.0328 8.61128 0 0 0 5.37782 0 0 0 10.2623 5.20844 3.99268 0 P45844 ABCG1_HUMAN ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog) ABCG1 ABC8 WHT1 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol metabolic process [GO:0090181]; response to lipid [GO:0033993]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] ABC-type sterol transporter activity [GO:0034041]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; toxin transmembrane transporter activity [GO:0019534] EGMCDSDHK;ITSHIGIGLLIGLLYLGIGNEAKK;LIAYFVLRYKIR;VCNLVPYLR;VRRGWSVCTAILLAR 5 8.8 0.85891 -0.082495 0 0 0 0 3.63483 0 0 0 0 0 0 0 P45880 VDAC2_HUMAN Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) VDAC2 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial transmembrane transport [GO:1990542]; monoatomic anion transport [GO:0006820]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein polymerization [GO:0032272]; phospholipid translocation [GO:0045332] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; sperm midpiece [GO:0097225] ATP binding [GO:0005524]; ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142]; phosphatidylcholine binding [GO:0031210]; phospholipid scramblase activity [GO:0017128]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]; voltage-gated monoatomic ion channel activity [GO:0005244] LTLSALVDGK;NNFAVGYR;VNNSSLIGVGYTQTLRPGVK;YQLDPTASISAK 4 17 0 3.4675 0 2.92928 5.17979 8.75692 0 0 11.565 10.9492 10.5049 10.6182 10.4736 11.6877 P45954 ACDSB_HUMAN "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; short-chain 2-methyl fatty acyl-CoA dehydrogenase activity [GO:0003853]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937] VGSFCLSEAGAGSDSFALK 1 4.4 0.64286 0.17191 0 0 0 0 0 0 0 0 8.18646 0 0 0 P45974 UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) USP5 ISOT Homo sapiens (Human) negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; regulation protein catabolic process at presynapse [GO:0140251] cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; presynapse [GO:0098793] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] AELSEEALLSVLPTIR;AELSEEALLSVLPTIRVPK;DLGYIYFYQR;EVQDGIAPR 4 4.4 0 62.888 10.511 10.4221 8.92769 0 0 0 0 11.7801 11.0464 0 0 0 P45983 MK08_HUMAN Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) MAPK8 JNK1 PRKM8 SAPK1 SAPK1C Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular senescence [GO:0090398]; energy homeostasis [GO:0097009]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; JUN phosphorylation [GO:0007258]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell killing [GO:0031343]; positive regulation of cyclase activity [GO:0031281]; positive regulation of establishment of protein localization to mitochondrion [GO:1903749]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein metabolic process [GO:0051247]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; stress-activated MAPK cascade [GO:0051403] axon [GO:0030424]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; JUN kinase activity [GO:0004705]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283] ELIYKEVMDLEERTK;EVMDLEERTK;TAGTSFMMTPYVVTR 3 7 0.95485 -0.97289 7.58999 0 0 0 0 0 0 11.0151 11.242 0 0 0 P45985 MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 Homo sapiens (Human) cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to mechanical stimulus [GO:0071260]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of DNA replication [GO:0045740]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; smooth muscle cell apoptotic process [GO:0034390] axon [GO:0030424]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634]; perikaryon [GO:0043204] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; molecular adaptor activity [GO:0060090]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] STVDEKEQK 1 2.3 0.97802 -1.5282 0 0 0 0 0 10.4389 0 0 0 0 0 0 P46013 KI67_HUMAN Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) MKI67 Homo sapiens (Human) cell population proliferation [GO:0008283]; chromosome segregation [GO:0007059]; regulation of chromatin organization [GO:1902275]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088] chromosome [GO:0005694]; condensed chromosome [GO:0000793]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723] ATLLQQRREGEMK;DIIIFVGTPVQKLDLTENLTGSK;DINTFVGTPVEK;EIERPFETYK;ESAKQMLDPANYGTGMER;ESAQAIEDLAGFK;KIIKEQPQPSGK;KLDAEDVIGSRR;KNESPFWK;LQDSVPENK;QILDPAAR;QILDPAASVTGSRR;RRPKTPLGK;SGGSGHAVAEPASPEQELDQNKGKGR;SGNLPSK;SQKENVLQYCRK;SQSKSNTSLPPLPFKR;SSFSSDPDEK;SSQPDPDK;VEDAADSATKPENLSSK;VPGGEDK 21 8.1 0.97584 -4.3486 12.8205 13.6123 13.4728 0 11.0399 10.2922 10.5331 7.967 11.8532 8.74204 11.0657 12.1926 P46019 KPB2_HUMAN "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" PHKA2 PHKLA PYK Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; protein modification process [GO:0036211] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] DGYKTPREDPNR;YGCCRFLR 2 1.6 0.77 0.056112 0 0 0 0 0 7.18844 0 0 0 0 0 0 P46020 KPB1_HUMAN "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)" PHKA1 PHKA Homo sapiens (Human) generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] TLGADDTMLAK;VEIHLPR;VLQKCHGLSVEGFVLPSSTTR;YGCCRFLR 4 3.8 0.97337 -2.4916 0 9.25463 0 0 0 0 0 10.8235 0 0 9.35751 0 P46059 S15A1_HUMAN "Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)" SLC15A1 PEPT1 Homo sapiens (Human) dipeptide import across plasma membrane [GO:0140206]; monoatomic ion transport [GO:0006811]; protein transport [GO:0015031]; tripeptide import across plasma membrane [GO:0140207] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; plasma membrane [GO:0005886] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427]; tripeptide transmembrane transporter activity [GO:0042937] EHWLDWAK;QGQRHTLLVWAPNHYQVVK 2 3.8 0.93674 -0.5511 12.4747 0 0 0 0 0 0 0 0 0 0 8.70311 P46060 RAGP1_HUMAN Ran GTPase-activating protein 1 (RanGAP1) RANGAP1 KIAA1835 SD Homo sapiens (Human) activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165] aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SUMO ligase complex [GO:0106068] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] LAETLAK;LENDGATALAEAFR;LKELNLSFCEIK 3 5.6 0.95532 -0.81187 0 10.342 0 0 0 0 0 0 0 0 8.59216 0 P46063 RECQ1_HUMAN "ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)" RECQL RECQ1 RECQL1 Homo sapiens (Human) DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] AESSQTCHSEQGDK;DSAFERK;LIDSWMGK;MCDNCCK;MCDNCCKDSAFER;VAGVVAPTLPR 6 7.2 0.056604 0.46514 0 8.39107 8.61408 0 0 5.65535 10.1938 0 0 10.3734 12.0126 0 P46087 NOP2_HUMAN 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) NOP2 NOL1 NSUN1 Homo sapiens (Human) maturation of LSU-rRNA [GO:0000470]; positive regulation of cell population proliferation [GO:0008284]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383] AEGIREPK;DLAQALINR;GISAGAVQTAGK;LGSVEAPK 4 4.6 0.97509 -2.3739 0 0 10.881 0 0 0 0 0 0 0 0 0 P46089 GPR3_HUMAN G-protein coupled receptor 3 (ACCA orphan receptor) GPR3 ACCA Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of meiotic nuclear division [GO:0040020]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VLWAVCCCCSSSK 1 3.9 0.80842 0.011128 0 0 0 0 0 0 0 0 0 0 0 4.5961 P46091 CML2_HUMAN Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1) CMKLR2 GPR1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; neuropeptide signaling pathway [GO:0007218] intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923] HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVK 1 9 0.6138 0.17447 0 0 8.20315 0 0 0 0 0 0 0 0 0 P46092 CCR10_HUMAN C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2) CCR10 GPR2 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930] AHLVSVIVWLLSLLLALPALLFSQDGQREGQR;TLLAARGPER 2 11.6 0.96672 -1.2666 0 0 0 0 0 0 8.17113 0 0 0 0 0 P46098 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) HTR3A 5HT3R HTR3 Homo sapiens (Human) inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] cleavage furrow [GO:0032154]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; serotonin binding [GO:0051378]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEK 1 7.9 0.91563 -0.39629 0 11.3625 0 0 0 0 0 0 0 0 0 0 P46100 ATRX_HUMAN Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) "cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]" "chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; single-stranded 3'-5' DNA helicase activity [GO:1990518] DDKLRTETQNALK;DQSDETSEDDK;EAIYNDVLTKQQMLISCVQR;EDGCNSSDK;ENLLGSIKEFR;ERRNLSSK;GDSCDSSEDK;GKSAKSSIISK;KWAEEFNDETNVR;LDGSTTAQSR;TLYDLKTQAGK;VAETKEK;WLRNIDYYR;YSMKEDGCNSSDK 14 5.9 0.97872 -11.281 16.1108 13.4653 11.1312 10.5161 0 13.1337 10.7825 6.51172 0 13.2011 7.71589 0 P46108 CRK_HUMAN Adapter molecule crk (Proto-oncogene c-Crk) (p38) CRK Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to endothelin [GO:1990859]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nitric oxide [GO:0071732]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; lipid metabolic process [GO:0006629]; negative regulation of cell motility [GO:2000146]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of wound healing [GO:0061045]; neuron migration [GO:0001764]; positive regulation of cell growth [GO:0030307]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; protein localization to membrane [GO:0072657]; reelin-mediated signaling pathway [GO:0038026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell shape [GO:0008360]; regulation of dendrite development [GO:0050773]; regulation of GTPase activity [GO:0043087]; regulation of intracellular signal transduction [GO:1902531]; regulation of signal transduction [GO:0009966]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cholecystokinin [GO:0061847]; response to hepatocyte growth factor [GO:0035728]; response to hydrogen peroxide [GO:0042542]; response to peptide [GO:1901652]; response to yeast [GO:0001878] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cytoskeletal protein binding [GO:0008092]; ephrin receptor binding [GO:0046875]; insulin-like growth factor receptor binding [GO:0005159]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]; protein phosphorylated amino acid binding [GO:0045309]; protein tyrosine kinase binding [GO:1990782]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin protein ligase binding [GO:0031625] QEEAEYVR;VTKINVSGQWEGECNGK 2 8.2 0.94476 -0.62962 0 0 0 0 0 9.32724 0 0 0 0 0 0 P46109 CRKL_HUMAN Crk-like protein CRKL Homo sapiens (Human) acetylcholine receptor signaling pathway [GO:0095500]; anterior/posterior pattern specification [GO:0009952]; B cell apoptotic process [GO:0001783]; blood vessel development [GO:0001568]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to interleukin-7 [GO:0098761]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; chordate pharynx development [GO:0160093]; cranial skeletal system development [GO:1904888]; dendrite development [GO:0016358]; endothelin receptor signaling pathway [GO:0086100]; enzyme-linked receptor protein signaling pathway [GO:0007167]; establishment of cell polarity [GO:0030010]; fibroblast growth factor receptor signaling pathway [GO:0008543]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; parathyroid gland development [GO:0060017]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glial cell migration [GO:1903977]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; Ras protein signal transduction [GO:0007265]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell growth [GO:0001558]; regulation of dendrite development [GO:0050773]; regulation of T cell migration [GO:2000404]; retinoic acid receptor signaling pathway [GO:0048384]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; urogenital system development [GO:0001655] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of postsynaptic membrane [GO:0098890]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591] KGEILVIIEKPEEQWWSARNK 1 6.9 0.76569 0.066865 0 0 10.6916 0 0 0 0 0 0 0 0 0 P46379 BAG6_HUMAN Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) BAG6 BAT3 G3 Homo sapiens (Human) apoptotic process [GO:0006915]; brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ERAD pathway [GO:0036503]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; maintenance of unfolded protein [GO:0036506]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; NK T cell activation [GO:0051132]; positive regulation of ERAD pathway [GO:1904294]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511] BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; receptor ligand activity [GO:0048018]; ribosome binding [GO:0043022]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381] LQPFLQR;LVMAQHMIR;VLQDDKK 3 2 0.96669 -1.2647 0 0 0 0 0 0 0 0 11.8318 0 0 0 P46439 GSTM5_HUMAN Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5) GSTM5 Homo sapiens (Human) glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; intercellular bridge [GO:0045171] glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802] IFEPKCLDAFLNLKDFISR;ITQSNAILR;MPMTLGYWDIR 3 17.9 0.84658 -0.066191 0 0 6.68342 0 0 0 0 8.04439 0 0 0 0 P46459 NSF_HUMAN Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) NSF Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein disaggregase activity [GO:0140545]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075] AAQSTAMNR;FSNLVLQALLVLLKK;SQLSCVVVDDIER 3 5 0.92339 -0.44757 0 0 0 0 0 0 0 0 0 3.79514 0 10.2036 P46527 CDN1B_HUMAN Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) CDKN1B KIP1 p27 Homo sapiens (Human) "autophagic cell death [GO:0048102]; cellular response to antibiotic [GO:0071236]; cellular response to hypoxia [GO:0071456]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; epithelial cell apoptotic process [GO:1904019]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; inner ear development [GO:0048839]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]; placenta development [GO:0001890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; potassium ion transport [GO:0006813]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration [GO:0030334]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of exit from mitosis [GO:0007096]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lens fiber cell differentiation [GO:1902746]; response to amino acid [GO:0043200]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]" Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase regulator activity [GO:0019914]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; Hsp70 protein binding [GO:0030544]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin protein ligase binding [GO:0031625] HCRDMEEASQR 1 5.6 0.92405 -0.4481 0 0 0 0 0 0 0 0 0 0 5.78443 0 P46531 NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) "animal organ regeneration [GO:0031100]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-ion regulated exocytosis [GO:0017156]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to tumor cell [GO:0071228]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chemical synaptic transmission, postsynaptic [GO:0099565]; cilium assembly [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary sinus valve morphogenesis [GO:0003182]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epidermal cell fate specification [GO:0009957]; epithelial cell fate commitment [GO:0072148]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; inhibition of neuroepithelial cell differentiation [GO:0002085]; interleukin-17-mediated signaling pathway [GO:0097400]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; luteolysis [GO:0001554]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; retinal cone cell differentiation [GO:0042670]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; T-helper 17 type immune response [GO:0072538]; tissue regeneration [GO:0042246]; transcription by RNA polymerase II [GO:0006366]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685] "calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; transcription coactivator activity [GO:0003713]; transcription regulator activator activity [GO:0140537]; transmembrane signaling receptor activity [GO:0004888]" AGHTGRR;CEGDVNECLSNPCDARGTQNCVQR;CRCPPGWSGK;LLDEYNLVR;RCESVINGCKGKPCK 5 2.5 0.97511 -3.077 0 12.0661 0 0 0 0 5.23485 0 0 0 0 10.2379 P46721 SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3) SLCO1A2 OATP OATP1 OATP1A2 SLC21A3 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857] LHRPIMIGIGCVVMGLGCFLK 1 3.1 0.64724 0.17086 9.896 0 0 0 0 0 0 0 0 0 0 0 P46736 BRCC3_HUMAN Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) BRCC3 BRCC36 C6.1A CXorf53 Homo sapiens (Human) cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] cysteine-type deubiquitinase activity [GO:0004843]; enzyme regulator activity [GO:0030234]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593] LAELTGRPMR;LEQNQQHLQELQQEK;VDAVRIVHIHSVIILR 3 13 0.95425 -0.90905 0 0 0 8.07114 0 10.7087 0 0 0 0 0 0 P46776 RL27A_HUMAN Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) RPL27A Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] TGAAPIIDVVR 1 7.4 0 5.0492 13.7768 13.1148 13.3358 10.4355 11.074 9.97828 12.2178 12.4657 12.4812 11.6227 11.7236 11.8328 P46777 RL5_HUMAN Large ribosomal subunit protein uL18 (60S ribosomal protein L5) RPL5 MSTP030 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] 5S rRNA binding [GO:0008097]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] ENPVYEK;FPGYDSESK;GAVDGGLSIPHSTK;KAHAAIRENPVYEK;NSVTPDMMEEMYK;NSVTPDMMEEMYKK;QFSQYIK;VTNRDIICQIAYAR;YLMEEDEDAYK 9 27.6 0 5.5547 11.0422 11.0475 0 9.54822 0 0 10.8858 0 11.0375 10.5293 10.8159 0 P46778 RL21_HUMAN Large ribosomal subunit protein eL21 (60S ribosomal protein L21) RPL21 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GMGTVQK;HGVVPLATYMR;MTNTKGK;TNGKEPELLEPIPYEFMA 4 26.9 0.22282 0.30952 12.8518 11.8619 12.333 0 11.7308 6.95919 10.8342 11.0311 8.0863 14.7816 14.4372 0 P46779 RL28_HUMAN Large ribosomal subunit protein eL28 (60S ribosomal protein L28) RPL28 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ATLSSIR;LGETGQCCGEGPPTTGCNMGWR;QTYSTEPNNLK;SAHLQWMVVR;TVGVEPAADGK 5 37.4 0.68235 0.1655 0 0 5.39818 0 0 0 0 0 0 0 5.83474 0 P46779 RL28_HUMAN Large ribosomal subunit protein eL28 (60S ribosomal protein L28) RPL28 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ATLSSIR;QTYSTEPNNLK;SAHLQWMVVR;TVGVEPAADGK;VDRPYYSGLMR 5 29.6 0 2.7339 14.2843 11.7025 10.4987 0 0 10.4384 0 0 12.2639 11.5003 13.0094 0 P46781 RS9_HUMAN Small ribosomal subunit protein uS4 (40S ribosomal protein S9) RPS9 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] IGVLDEGK;LFEGNALLR;LQTQVFK;NAKKGQGGAGAGDDEEED;QVVNIPSFIVR 5 27.3 0.013807 0.80141 11.2756 11.0976 14.0017 9.07732 9.56682 9.15046 11.4717 11.9624 12.5611 11.1989 0 11.9374 P46782 RS5_HUMAN "Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)]" RPS5 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GSSNSYAIK;QAVDVSPLR;TEWETAAPAVAETPDIK;VNQAIWLLCTGAR 4 23.5 0 10.226 8.13843 5.53571 0 0 0 8.4814 8.17857 0 0 11.8474 11.8548 0 P46783 RS10_HUMAN Small ribosomal subunit protein eS10 (40S ribosomal protein S10) RPS10 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AEAGAGSATEFQFR;SAVPPGADK 2 13.9 0 5.2811 10.1809 11.6445 11.416 0 0 0 0 10.0189 10.1083 0 0 10.1476 P46821 MAP1B_HUMAN Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] MAP1B Homo sapiens (Human) axon extension [GO:0048675]; axonogenesis [GO:0007409]; cellular response to growth factor stimulus [GO:0071363]; cellular response to peptide hormone stimulus [GO:0071375]; dendrite development [GO:0016358]; developmental maturation [GO:0021700]; establishment of monopolar cell polarity [GO:0061162]; induction of synaptic plasticity by chemical substance [GO:0051915]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of intracellular transport [GO:0032387]; negative regulation of microtubule depolymerization [GO:0007026]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; odontoblast differentiation [GO:0071895]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axon extension [GO:0045773]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron differentiation [GO:0045666]; regulation of microtubule depolymerization [GO:0031114]; regulation of postsynapse assembly [GO:0150052]; response to carbohydrate [GO:0009743]; response to estradiol [GO:0032355]; response to insecticide [GO:0017085]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416] apical dendrite [GO:0097440]; axon [GO:0030424]; basal dendrite [GO:0097441]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber [GO:0097457]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]; varicosity [GO:0043196] actin binding [GO:0003779]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] EPKKEIK;GEAEQSEEEADEEDK;KPAALKPKVPKK;LSKPCCYIFPGGR;NPEPNIK;SSTPLSEAK;SVGNTIDPVILFQK;SVRKESK;TTRTPEEGGYSYDISEK;TTSPPEVSGYSYEK 10 4.7 0.004914 1.6125 0 2.82477 0 0 0 1.91632 13.0065 9.61631 3.99331 10.6103 9.48987 10.3798 P46926 GNPI1_HUMAN Glucosamine-6-phosphate deaminase 1 (GlcN6P deaminase 1) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 1) (Protein oscillin) GNPDA1 GNPI HLN KIAA0060 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; single fertilization [GO:0007338]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853] ETEKSQSSK;IIQFNPGPEK 2 6.6 0.86784 -0.093169 0 0 0 0 9.27449 0 0 0 0 0 10.839 0 P46934 NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) NEDD4 KIAA0093 NEDD4-1 RPF1 PIG53 Homo sapiens (Human) cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; formation of structure involved in a symbiotic process [GO:0044111]; innate immune response [GO:0045087]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of macroautophagy [GO:0016241]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755] apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] beta-2 adrenergic receptor binding [GO:0031698]; enzyme binding [GO:0019899]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] ATVLEDSYRR;IFYINHNIK;LLQFVTGTSR;TRDDFLGQVDVPLYPLPTENPR 4 3.9 0.96454 -1.197 0 0 0 0 0 9.6525 11.9666 10.1556 12.3096 7.99763 0 0 P46937 YAP1_HUMAN Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) YAP1 YAP65 Homo sapiens (Human) bud elongation involved in lung branching [GO:0060449]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue regeneration [GO:0061026]; cell morphogenesis [GO:0000902]; cellular response to gamma radiation [GO:0071480]; cellular response to retinoic acid [GO:0071300]; DNA damage response [GO:0006974]; embryonic heart tube morphogenesis [GO:0003143]; enterocyte differentiation [GO:1903703]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway [GO:0097191]; glandular epithelial cell differentiation [GO:0002067]; heart process [GO:0003015]; hippo signaling [GO:0035329]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; keratinocyte differentiation [GO:0030216]; lateral mesoderm development [GO:0048368]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cilium assembly [GO:1902018]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; organ growth [GO:0035265]; paraxial mesoderm development [GO:0048339]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of keratinocyte proliferation [GO:0010837]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to progesterone [GO:0032570]; somatic stem cell population maintenance [GO:0035019]; tissue homeostasis [GO:0001894]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; wound healing [GO:0042060] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; TEAD-YAP complex [GO:0140552] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; proline-rich region binding [GO:0070064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] LPDSFFKPPEPKSHSR;LQQLQMEK;NKTTSWLDPR;QQELLRQVRPQELALR 4 10.2 0.97464 -3.0985 11.8684 0 0 11.4955 11.3481 11.1575 11.7687 0 11.6703 5.94666 0 11.9956 P46939 UTRN_HUMAN Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; synaptic signaling [GO:0099536] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383] actin binding [GO:0003779]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270] ELVEPKLAELNR;ELVEPKLAELNRNFEK;EYMKMQDTSEMK;IIADLEEEQR;IRLQLLLLHTR;KQLQQLSAWLTLTEER;LAGLNQR;LHDVLMELQK;LSQADGSFLK;MSRQLDDLNMRWK;NVHPDVEKLYKQEFDDVQGK;SQPLTSPESRTAR;TWVQTRLGDYQTQLEK;VAAAETAK 14 4.7 0.97478 -3.0636 0 10.3206 0 10.0962 10.4506 4.23871 9.399 0 11.7956 0 11.6676 10.9781 P46940 IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 KIAA0051 Homo sapiens (Human) caveola assembly [GO:0070836]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast migration [GO:0010761]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of dephosphorylation [GO:0035305]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165] actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle [GO:0001726]; secretory granule membrane [GO:0030667]; slit diaphragm [GO:0036057] "actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; MAP-kinase scaffold activity [GO:0005078]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]; S100 protein binding [GO:0044548]; small GTPase binding [GO:0031267]" ALESGDVNTVWK;ALQSPALGLR;EDSNLTLQEK;EQLWLANEGLITR;FALGIFAINEAVESGDVGK;GLQQQNSDWYLK;IFYPETTDIYDR;IFYPETTDIYDRK;ILAIGLINEALDEGDAQK;LAAVALINAAIQK;LAVGDNNSK;LGNFFSPK;LIVDVIR;LPYDVTPEQALAHEEVK;LQQTYAALNSK;LTAEEMDER;LTELGTVDPK;MLQHAASNK;NLGSIAK;QSGQTDPLQK;TALQEEIK;TCLDNLASK;TDPVDIYK;TENSERER;TLINAEDPPMVVVR;TLQALQIPAAK;VDQIQEIVTGNPTVIK;VLKDSLHEKFPDAGEDELLK;YLDELMK;YQELINDIARDIRNQR 30 20.2 0 55.74 0 9.56729 4.50093 0 6.98971 8.66377 12.5563 13.5396 14.2956 13.8885 13.7736 11.1552 P46976 GLYG_HUMAN Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) GYG1 GYG Homo sapiens (Human) glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803] NGRNDGNRAR;SQLWHSRLYPR 2 7.5 0.98136 -1.7067 0 0 0 0 0 0 0 0 0 0 0 6.58529 P46977 STT3A_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC) STT3A ITM1 TMC Homo sapiens (Human) co-translational protein modification [GO:0043686]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250] dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] FGQVYTEAK;LLILSMAAVLSFSTR 2 3.4 0.76904 0.057534 0 0 13.9678 0 0 0 0 0 0 0 0 0 P47736 RPGP1_HUMAN Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) RAP1GAP KIAA0474 RAP1GA1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; negative regulation of microvillus assembly [GO:1903697]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of thyroid gland epithelial cell proliferation [GO:1904442]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] AEKFAKLEER;RSSAIGIENIQEVQEKR;RSVWRSDGQNQHFPQALDLSR 3 6.6 0.98206 -1.5858 0 0 0 0 0 0 0 0 0 0 6.11925 10.1775 P47755 CAZA2_HUMAN F-actin-capping protein subunit alpha-2 (CapZ alpha-2) CAPZA2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; protein-containing complex assembly [GO:0065003] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020] actin filament binding [GO:0051015] ADLEEQLSDEEK;LLLNNDNLLR 2 12.8 0.013834 0.80712 0 0 0 0 0 0 8.02131 0 0 9.30675 8.4424 8.37951 P47756 CAPZB_HUMAN F-actin-capping protein subunit beta (CapZ beta) CAPZB Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm head-tail coupling apparatus [GO:0120212]; WASH complex [GO:0071203] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] SGSGTMNLGGSLTR;STLNEIYFGK;SVQTFADK 3 11.8 0 2.8256 0 6.06083 0 0 0 0 8.83485 11.4832 0 11.7082 9.85425 0 P47756 CAPZB_HUMAN F-actin-capping protein subunit beta (CapZ beta) CAPZB Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm head-tail coupling apparatus [GO:0120212]; WASH complex [GO:0071203] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] SGSGTMNLGGSLTR;SIDAIPDNQKFKQLQR;STLNEIYFGK 3 14.4 0.44184 0.19356 9.14489 0 0 0 0 0 0 0 0 0 0 0 P47869 GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) (GABAAR subunit alpha-2) GABRA2 Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LIWSKYIAFSWPSLFQEK;LIWSKYIAFSWPSLFQEKTLEYLEK 2 5.5 0.97758 -1.5219 0 0 0 0 0 0 0 0 9.45728 8.09956 0 0 P47870 GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) (GABAAR subunit beta-2) GABRB2 Homo sapiens (Human) "cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] MRLDVNKVNSEGKPSLLLK;NRMIRLHPDGTVLYGLR 2 11.5 0.96405 -1.0942 0 0 0 0 0 0 0 0 0 0 9.88194 0 P47871 GLR_HUMAN Glucagon receptor (GL-R) GCGR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucagon stimulus [GO:0071377]; cellular response to starvation [GO:0009267]; exocytosis [GO:0006887]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of gene expression [GO:0010628]; regulation of blood pressure [GO:0008217]; regulation of glycogen metabolic process [GO:0070873]; response to nutrient [GO:0007584]; response to starvation [GO:0042594] endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886] glucagon receptor activity [GO:0004967]; guanyl-nucleotide exchange factor activity [GO:0005085]; peptide hormone binding [GO:0017046] VLWEERNTSNHR 1 2.5 0.917 -0.41307 0 0 0 0 0 0 0 0 12.127 0 0 0 P47872 SCTR_HUMAN Secretin receptor (SCT-R) (SECR) SCTR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; diet induced thermogenesis [GO:0002024]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular water homeostasis [GO:0009992]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667] cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; secretin receptor activity [GO:0015055] LCDVLQVLWEEQDQCLQELSR 1 4.8 0.65544 0.16939 0 0 0 0 0 7.58767 0 0 0 0 0 0 P47881 OR3A1_HUMAN Olfactory receptor 3A1 (Olfactory receptor 17-40) (OR17-40) (Olfactory receptor OR17-15) OR3A1 OLFRA03 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NPDVQSAIWRMLTGR 1 4.8 0.78482 0.02473 0 0 0 6.04917 0 0 0 0 0 0 0 0 P47884 OR1D4_HUMAN Olfactory receptor 1D4 (Olfactory receptor 17-30) (OR17-30) OR1D4 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MLVNFQSQNK 1 3.2 0.93638 -0.52509 0 0 0 9.87075 0 0 0 0 0 0 0 0 P47888 OR3A3_HUMAN Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22) OR3A3 OR3A6 OR3A7 OR3A8P Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGSVESSDK 1 2.8 0.92873 -0.47189 0 0 0 0 0 0 10.0681 0 0 0 0 0 P47895 AL1A3_HUMAN Retinaldehyde dehydrogenase 3 (RALDH-3) (RalDH3) (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Aldehyde dehydrogenase family 1 member A3) (ALDH1A3) ALDH1A3 ALDH6 Homo sapiens (Human) apoptotic process [GO:0006915]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; face development [GO:0060324]; Harderian gland development [GO:0070384]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; nucleus accumbens development [GO:0021768]; olfactory pit development [GO:0060166]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; positive regulation of apoptotic process [GO:0043065]; protein homotetramerization [GO:0051289]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; retinal dehydrogenase activity [GO:0001758]; thyroid hormone binding [GO:0070324] ELGEYALAEYTEVK;VTLELGGK 2 4.3 0.87635 -0.12652 12.9347 0 0 0 0 0 0 0 0 0 0 0 P47897 SYQ_HUMAN Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS1 QARS Homo sapiens (Human) brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] AALDSLSLFTSLGLSEQK;DWDDPRLFTLTALRR;LNLHYAVVSK;LNLHYAVVSKR 4 5.7 0 82.626 10.8157 9.43536 9.16277 0 0 0 7.34518 8.2094 7.65657 0 8.79149 0 P47900 P2RY1_HUMAN P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) P2RY1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; blood vessel diameter maintenance [GO:0097746]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ATP [GO:0071318]; cellular response to purine-containing compound [GO:0071415]; eating behavior [GO:0042755]; establishment of localization in cell [GO:0051649]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; glial cell migration [GO:0008347]; monoatomic ion transport [GO:0006811]; negative regulation of norepinephrine secretion [GO:0010700]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hormone secretion [GO:0046887]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of penile erection [GO:0060406]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; relaxation of muscle [GO:0090075]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; signal transduction involved in regulation of gene expression [GO:0023019] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell surface [GO:0009986]; cilium [GO:0005929]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787] A1 adenosine receptor binding [GO:0031686]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled ATP receptor activity [GO:0045031]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; protein heterodimerization activity [GO:0046982]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023] ALIYKDLDNSPLR;GLASLNSCVDPILYFLAGDTFR;LSRATRK 3 11.3 0.98047 -1.6674 0 0 0 5.26097 0 0 0 8.13021 0 0 0 0 P47914 RL29_HUMAN Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (Cell surface heparin-binding protein HIP) RPL29 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; embryo implantation [GO:0007566]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020] cadherin binding [GO:0045296]; heparin binding [GO:0008201]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AEAIKALVKPKEVKPK;AQAAAPASVPAQAPK 2 19.5 0 6.0987 10.7614 11.4095 10.3861 10.0527 10.5646 0 0 0 0 11.7941 12.9927 3.50538 P47928 ID4_HUMAN DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) ID4 BHLHB27 Homo sapiens (Human) astrocyte differentiation [GO:0048708]; central nervous system myelination [GO:0022010]; cerebral cortex neuron differentiation [GO:0021895]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; hippocampus development [GO:0021766]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; protein localization [GO:0008104]; seminal vesicle morphogenesis [GO:0061682] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] AAEAAADEPALCLQCDMNDCYSR;KAPSGCGGGELALR 2 23 0.90931 -0.3107 0 0 0 0 0 0 0 4.36779 0 0 0 0 P47929 LEG7_HUMAN Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein) LGALS7 PIG1; LGALS7B Homo sapiens (Human) apoptotic process [GO:0006915]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634] carbohydrate binding [GO:0030246] LDTSEVVFNSK;VRLVEVGGDVQLDSVR 2 19.9 0.98053 -1.617 0 0 0 0 0 0 0 0 0 10.3136 12.3684 0 P47944 MT4_HUMAN Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV) MT4 Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] GGSDKCSCCP;SCCPCCPPGCAKCAR 2 40.3 0.97377 -1.4129 7.96382 0 0 0 0 0 0 0 0 0 0 0 P47974 TISD_HUMAN "mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)" ZFP36L2 ERF2 RNF162C TIS11D Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of B cell differentiation [GO:0045577]; regulation of mRNA stability [GO:0043488]; response to wounding [GO:0009611]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723] LSDSPVFDAPPSPPDSLSDR 1 4 0.60069 0.17759 0 10.1747 0 0 0 0 0 0 0 0 0 0 P47989 XDH_HUMAN Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH XDHA Homo sapiens (Human) adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; iron-sulfur cluster assembly [GO:0016226]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xanthine catabolic process [GO:0009115] cytosol [GO:0005829]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; sarcoplasmic reticulum [GO:0016529] "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; hypoxanthine oxidase activity [GO:0070675]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; protein homodimerization activity [GO:0042803]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]" ALFHMDNCYK;CMLDRDEDMLITGGRHPFLAR;DGGCCGGDGNNPNCCMNQKK;DKVTCVGHIIGAVVADTPEHTQR;LDPTFASATLLFQK;LDSPATPEK;LVFFVNGR;VKRMGGGFGGK;VTWIQASTLK 9 9.5 0.97518 -3.6091 0 9.66233 11.3225 0 0 0 9.52311 0 0 5.21167 0 4.82309 P48023 TNFL6_HUMAN "Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]" FASLG APT1LG1 CD95L FASL TNFSF6 Homo sapiens (Human) apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cellular response to type II interferon [GO:0071346]; endosomal lumen acidification [GO:0048388]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory cell apoptotic process [GO:0006925]; intracellular chloride ion homeostasis [GO:0030644]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylserine exposure on apoptotic cell surface [GO:1905782]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; retinal cell programmed cell death [GO:0046666]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231] caveola [GO:0005901]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] ELRKVAHLTGK;RPPPPPPPPPLPPPPPPPPLPPLPLPPLKKR 2 14.9 0.97287 -1.3738 0 0 0 0 5.11316 0 0 0 0 0 0 9.3778 P48039 MTR1A_HUMAN Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) MTNR1A Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159] QRVKPDRKPK 1 2.9 0.97772 -1.5187 0 0 0 0 0 0 0 0 0 0 9.40748 0 P48047 ATPO_HUMAN "ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP)" ATP5PO ATP5O ATPO Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259] "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" IGEKYVDMSVKTK;SLNDITAK;VAASVLNPYVK;YATALYSAASK 4 20.2 0.0046189 1.3145 0 12.2283 0 0 0 0 0 0 0 0 11.9947 0 P48048 KCNJ1_HUMAN "ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)" KCNJ1 ROMK1 Homo sapiens (Human) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium channel activity [GO:0005267]" NVFDTLIRVLTESMFK 1 4.1 0.81149 0.0038554 0 11.6727 0 0 0 0 0 0 0 0 0 0 P48051 KCNJ6_HUMAN "G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)" KCNJ6 GIRK2 KATP2 KCNJ7 Homo sapiens (Human) potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242] CNVHHGNVRETYR;VGDLRNSHIVEASIR 2 6.6 0.95471 -0.88524 0 0 0 0 0 0 0 7.55926 0 0 0 8.2183 P48052 CBPA2_HUMAN Carboxypeptidase A2 (EC 3.4.17.15) CPA2 Homo sapiens (Human) protein catabolic process in the vacuole [GO:0007039]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615]; vacuole [GO:0005773] carboxypeptidase activity [GO:0004180]; metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] NLLQLEAQEHLQLDFWK 1 4.1 0.64075 0.17288 0 0 0 0 0 0 10.5179 0 0 0 0 0 P48058 GRIA4_HUMAN "Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4)" GRIA4 GluA4 GLUR4 Homo sapiens (Human) "glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; extracellular vesicle [GO:1903561]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GECGPKDSGSK;LSEAGVLDK;RMKLTFSEAIR;VGGNLDSK;VLTPDCPK 5 5.2 0.9782 -2.13 0 0 0 0 9.77645 0 0 3.44639 9.61708 0 0 0 P48059 LIMS1_HUMAN LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) LIMS1 PINCH PINCH1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; establishment of protein localization [GO:0045184]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin binding [GO:0003779]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] CEKPFLGHRHYERK;ELSHSGLYRR;ELTADARELKGELYCLPCHDK;GLGKYICQK;MTALQLKELSHSGLYR 5 16.9 0.98027 -1.554 0 0 0 0 0 8.63891 0 7.97453 0 7.28707 7.69648 0 P48060 GLIP1_HUMAN Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1) GLIPR1 GLIPR RTVP1 Homo sapiens (Human) azurophil granule membrane [GO:0035577]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] ICKKVCGHYTQVSQER 1 6.8 0.85046 -0.075876 0 0 0 9.85276 0 0 0 0 8.74382 0 0 0 P48061 SDF1_HUMAN Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)] CXCL12 SDF1 SDF1A SDF1B Homo sapiens (Human) adult locomotory behavior [GO:0008344]; animal organ regeneration [GO:0031100]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; defense response [GO:0006952]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; integrin activation [GO:0033622]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neuron migration [GO:0001764]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T cell migration [GO:2000406]; positive regulation of vasculature development [GO:1904018]; regulation of actin polymerization or depolymerization [GO:0008064]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; signal transduction [GO:0007165]; telencephalon cell migration [GO:0022029] collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; CXCR chemokine receptor binding [GO:0045236]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102] CPCRFFESHVARANVK;WIQEYLEKALNKGR 2 25.2 0.96519 -1.238 0 0 0 9.93921 0 6.91552 0 0 0 0 0 0 P48066 S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) SLC6A11 GABT3 GAT3 Homo sapiens (Human) amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725] cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amino acid binding [GO:0016597]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine:sodium symporter activity [GO:0005369] TAEKALPLGNGK 1 1.9 0.92394 -0.44879 0 6.77255 0 0 0 0 0 0 0 0 0 0 P48067 SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) "glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; neurotransmitter transport [GO:0006836]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375] LKNATKPSRDWGPALLEHR;MSGGDTR;SFFLPPFSGATPSTSLAESVLK 3 6.8 0.87856 -0.14406 5.60012 0 0 0 9.0578 7.87848 15.4093 0 0 10.2233 13.1708 0 P48067 SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) "glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; neurotransmitter transport [GO:0006836]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375] LKNATKPSRDWGPALLEHR;MVGKGAK 2 4.1 0.64972 0.17047 12.3636 0 0 0 0 0 0 0 11.1942 0 0 0 P48145 NPBW1_HUMAN Neuropeptides B/W receptor type 1 (G-protein coupled receptor 7) NPBWR1 GPR7 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of metabolic process [GO:0019222] membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled opioid receptor activity [GO:0004985]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] YLVVLATAESRRVAGR 1 4.9 0.85064 -0.075815 0 4.76522 0 0 0 0 0 0 0 0 0 0 P48147 PPCE_HUMAN Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP PEP Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] AFVEAQNK;LSLQYPDVYR;VLYVQDSLEGEAR 3 4.4 0.034483 0.54814 11.6914 0 14.9285 0 0 0 0 0 11.4305 0 0 0 P48163 MAOX_HUMAN NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) ME1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; nucleotide biosynthetic process [GO:0009165]; protein homotetramerization [GO:0051289]; pyruvate metabolic process [GO:0006090]; regulation of NADP metabolic process [GO:1902031]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; manganese ion binding [GO:0030145]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxaloacetate decarboxylase activity [GO:0008948] AIVVTDGER;TATVYPEPQNK 2 3.5 0.02243 0.60784 0 12.2098 12.3349 0 0 0 0 0 0 0 0 0 P48165 CXA8_HUMAN Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) GJA8 Homo sapiens (Human) cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645] connexin complex [GO:0005922]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802] ILPLYRCSR 1 2.1 0.89705 -0.24044 0 13.0339 0 0 0 0 0 0 0 0 0 0 P48167 GLRB_HUMAN Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) GLRB Homo sapiens (Human) "acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid receptor clustering [GO:0097112]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuropeptide signaling pathway [GO:0007218]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glycine-gated chloride channel complex [GO:0016935]; glycinergic synapse [GO:0098690]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] extracellularly glycine-gated chloride channel activity [GO:0016934]; extracellularly glycine-gated ion channel activity [GO:0016933]; glycine binding [GO:0016594]; neurotransmitter receptor activity [GO:0030594]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GIPVDVVVNIFINSFGSIQETTMDYRVNIFLR;KPPPAKPVIPTAAKR;KVCTSKSDLR;SQAKNNKKPPPAKPVIPTAAK;VNIFLRQK 5 13.3 0.97494 -3.7003 0 9.60696 0 0 0 0 0 0 0 5.98548 8.20256 9.13758 P48169 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) GABRA4 Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LTISAECPMR;MVSAKKVPAIALSAGVSFALLR;SITGEYIVMTVYFHLRRK;YDGPIEILR 4 10.6 0.82882 -0.02336 10.6615 6.17541 0 0 0 0 0 10.5928 0 0 8.55221 0 P48200 IREB2_HUMAN Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) IREB2 Homo sapiens (Human) citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA binding [GO:0003723]" EDVMNILDWK;EFNSYGAR;STYIRCPSFFDK 3 3.1 0.955 -0.94702 0 0 9.05585 0 0 4.27672 5.19235 0 0 0 0 0 P48230 T4S4_HUMAN Transmembrane 4 L6 family member 4 (Intestine and liver tetraspan membrane protein) (IL-TMP) TM4SF4 ILTMP Homo sapiens (Human) tissue regeneration [GO:0042246] membrane [GO:0016020] NNDCCGCCGNEGCGKR 1 7.9 0.58786 0.17925 5.19948 0 0 0 0 0 0 0 0 0 0 0 P48357 LEPR_HUMAN Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) LEPR DB OBR Homo sapiens (Human) angiogenesis [GO:0001525]; bone growth [GO:0098868]; cell surface receptor signaling pathway [GO:0007166]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; glial cell proliferation [GO:0014009]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycogen metabolic process [GO:0005977]; leptin-mediated signaling pathway [GO:0033210]; multicellular organism development [GO:0007275]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; phagocytosis [GO:0006909]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein phosphorylation [GO:0001934]; regulation of bone remodeling [GO:0046850]; regulation of feeding behavior [GO:0060259]; regulation of transport [GO:0051049]; response to leptin [GO:0044321]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; leptin receptor activity [GO:0038021]; transmembrane signaling receptor activity [GO:0004888] EIVWWMNLAEK;EVQWKMYEVYDAK 2 2.1 0.91771 -0.42837 11.2783 6.60122 0 0 0 0 0 0 0 0 0 0 P48378 RFX2_HUMAN DNA-binding protein RFX2 (Regulatory factor X 2) RFX2 Homo sapiens (Human) acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DDMGDEQR;RHCEATVDVVMNLQFHYIEK 2 3.9 0.88182 -0.17932 0 0 0 0 6.61251 0 0 10.1461 0 0 0 0 P48380 RFX3_HUMAN Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) cell maturation [GO:0048469]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; DNA-templated transcription [GO:0006351]; endocrine pancreas development [GO:0031018]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell maturation [GO:0072560] chromatin [GO:0000785]; extracellular region [GO:0005576]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" SIFMGLR 1 0.9 0.91288 -0.322 0 0 0 0 0 0 0 7.69439 0 0 0 0 P48382 RFX5_HUMAN DNA-binding protein RFX5 (Regulatory factor X 5) RFX5 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" EAFPLAK;ILKRSFSSIVEVAR;LPLLLPRAPRSLIPPIPVSPPILAPR;VEGILQDVQK 4 9.3 0.90901 -0.31421 7.82693 0 9.14871 10.3493 0 9.8369 0 0 0 8.90038 0 0 P48426 PI42A_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PI5P4KA PIP5K2 PIP5K2A Homo sapiens (Human) "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; megakaryocyte development [GO:0035855]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; vesicle-mediated cholesterol transport [GO:0090119]" autophagosome [GO:0005776]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803] AKELPTLK;SAPLPNDSQARSGAR;YHQYIVECHGITLLPQFLGMYR 3 11.1 0.95502 -0.86606 0 0 0 0 0 0 0 11.0578 11.35 0 0 11.4902 P48436 SOX9_HUMAN Transcription factor SOX-9 SOX9 Homo sapiens (Human) anterior head development [GO:0097065]; aortic valve morphogenesis [GO:0003180]; astrocyte fate commitment [GO:0060018]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus cartilage development [GO:0060532]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate specification [GO:0001708]; cell proliferation involved in heart morphogenesis [GO:0061323]; cell-cell adhesion [GO:0098609]; cellular response to BMP stimulus [GO:0071773]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to heparin [GO:0071504]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte hypertrophy [GO:0003415]; chromatin remodeling [GO:0006338]; cochlea morphogenesis [GO:0090103]; cytoskeleton organization [GO:0007010]; endocardial cushion morphogenesis [GO:0003203]; endocrine pancreas development [GO:0031018]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in prostatic bud elongation [GO:0060517]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERK1 and ERK2 cascade [GO:0070371]; extracellular matrix assembly [GO:0085029]; glandular epithelial cell differentiation [GO:0002067]; glial cell fate specification [GO:0021780]; growth plate cartilage chondrocyte growth [GO:0003430]; hair follicle development [GO:0001942]; Harderian gland development [GO:0070384]; heart development [GO:0007507]; heart valve development [GO:0003170]; heart valve formation [GO:0003188]; heart valve morphogenesis [GO:0003179]; intestinal epithelial cell differentiation [GO:0060575]; intestinal epithelial structure maintenance [GO:0060729]; intrahepatic bile duct development [GO:0035622]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; lung smooth muscle development [GO:0061145]; male germ-line sex determination [GO:0019100]; male gonad development [GO:0008584]; mammary gland development [GO:0030879]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation [GO:0010463]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of bone mineralization [GO:0030502]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of gene expression [GO:0010629]; negative regulation of immune system process [GO:0002683]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; neural crest cell fate specification [GO:0014036]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; notochord development [GO:0030903]; nucleosome assembly [GO:0006334]; oligodendrocyte differentiation [GO:0048709]; otic vesicle formation [GO:0030916]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; positive regulation of male gonad development [GO:2000020]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein localization to nucleus [GO:0034504]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of branching involved in lung morphogenesis [GO:0061046]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle process [GO:0010564]; regulation of cell population proliferation [GO:0042127]; regulation of cell proliferation involved in tissue homeostasis [GO:0060784]; regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000794]; renal vesicle induction [GO:0072034]; response to fatty acid [GO:0070542]; response to organic cyclic compound [GO:0014070]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; type I pneumocyte differentiation [GO:0060509]; ureter morphogenesis [GO:0072197]; ureter smooth muscle cell differentiation [GO:0072193]; ureter urothelium development [GO:0072190] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; pre-mRNA intronic binding [GO:0097157]; protein kinase A catalytic subunit binding [GO:0034236]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ESEEDKFPVCIR;TDVQPGKADLK 2 4.5 0.94391 -0.62824 0 0 0 9.2864 0 0 6.62188 0 0 0 0 0 P48443 RXRG_HUMAN Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma) RXRG NR2B3 Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinoic acid receptor signaling pathway [GO:0048384] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" AIVLFNPDAK;CQYCRYQK;EAVQEERQRSR;HYGVYSCEGCKGFFKR 4 9.7 0.95634 -0.99538 6.05298 0 7.12959 0 0 0 7.57213 0 10.719 0 8.91436 8.49518 P48444 COPD_HUMAN Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) ARCN1 COPD Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer maturation [GO:0021691]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi localization [GO:0051645]; intracellular protein transport [GO:0006886]; pigmentation [GO:0043473]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] RNA binding [GO:0003723] AKELQQAR;AVRETQEREAK;ENVNLAQIR;SFPVNSDVGVLK;VTQVDGNSPVR;YVYQPMEK 6 11.5 0.0085653 1.0057 8.57856 9.15325 9.10682 0 9.47719 0 0 0 0 0 11.4566 11.8882 P48449 LSS_HUMAN "Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)" LSS OSC Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; regulation of protein stability [GO:0031647]; steroid biosynthetic process [GO:0006694]; triterpenoid biosynthetic process [GO:0016104] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] lanosterol synthase activity [GO:0000250] QELYVEDFASIDWLAQR;QMADGGWGEDFESCEER 2 4.6 0.73978 0.10601 0 0 0 11.4964 0 0 3.37712 0 0 0 0 0 P48454 PP2BC_HUMAN "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)" PPP3CC CALNA3 CNA3 Homo sapiens (Human) calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein dephosphorylation [GO:0006470] calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; presynapse [GO:0098793]; protein serine/threonine phosphatase complex [GO:0008287] calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AIGKMAR;HLTDYFTFK;SDQGKKAHS 3 4.9 0.98181 -1.5818 13.1114 0 0 0 0 0 0 0 0 9.89853 0 0 P48506 GSH1_HUMAN Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) GCLC GLCL GLCLC Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877] DAVLQGMFYFR;RASGELMTVARWMR;SRYDSIDSYLSKCGEK;VDENMKVAQK;VLETLQEK;VVINVPIFKDK;YNDIDLTIDK 7 12.6 0.97665 -5.4778 7.39558 0 0 0 0 0 11.6594 9.84456 13.1668 0 9.03312 0 P48507 GSH0_HUMAN Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) GCLM GLCLR Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109] glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; glutamate-cysteine ligase regulator activity [GO:1990609]; protein-containing complex binding [GO:0044877] IVAIGTSDLDK 1 4 0.89855 -0.2313 0 0 0 0 0 0 0 9.83172 0 0 0 0 P48509 CD151_HUMAN CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) CD151 TSPAN24 Homo sapiens (Human) "cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; T cell proliferation [GO:0042098]; wound healing, spreading of cells [GO:0044319]" basement membrane [GO:0005604]; cell surface [GO:0009986]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] integrin binding [GO:0005178] TVVALCGQRDHASNIYK 1 6.7 0.91538 -0.3689 0 0 0 0 0 0 0 0 0 7.07253 0 0 P48546 GIPR_HUMAN Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor) GIPR Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; endocrine pancreas development [GO:0031018]; gastric inhibitory peptide signaling pathway [GO:0038192]; generation of precursor metabolites and energy [GO:0006091]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of insulin secretion [GO:0032024]; regulation of insulin secretion [GO:0050796]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to fatty acid [GO:0070542]; response to glucose [GO:0009749]; response to nutrient [GO:0007584] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; gastric inhibitory peptide receptor activity [GO:0016519]; glucagon family peptide binding [GO:0120022]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888] ALPSGSGPGEVPTSR;LQVMYTVGYSLSLATLLLALLILSLFRR 2 9.2 0.079745 0.39781 0 0 0 3.82609 0 6.12017 0 0 0 0 0 0 P48552 NRIP1_HUMAN Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) NRIP1 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; lipid storage [GO:0019915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ovarian follicle rupture [GO:0001543]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] LAAMARLQENGQK;LLQSSEDWNAAK;SWARESK;TEKSESDQPVSLDNFTQSLLNTWDPK;VPDVDIK 5 5.6 0.97797 -2.0647 0 0 0 0 8.59492 0 6.96913 0 0 0 9.76403 0 P48553 TPC10_HUMAN Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) TRAPPC10 EHOC1 TMEM1 Homo sapiens (Human) early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] QSDRCVVLSDPLK;SWNGLILR;VENFFTLYNVK;VENFFTLYNVKAEIFPPSGMEYCR 4 3.6 0.95507 -0.90197 0 0 0 0 10.4737 9.97111 0 0 4.92148 9.59735 0 0 P48556 PSMD8_HUMAN 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) PSMD8 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]" ILFFNTPK;ILFTEATRILFFNTPK;YMAQLKCYYFDYK 3 8.3 0.95548 -0.8539 0 8.18606 0 0 0 0 10.1668 0 0 0 0 0 P48594 SPB4_HUMAN Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2) SERPINB4 PI11 SCCA2 Homo sapiens (Human) negative regulation of peptidase activity [GO:0010466]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of proteolysis [GO:0030162] cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] TYQFLQEYLDAIK 1 3.3 0.80354 0.013307 0 0 0 8.51116 0 0 0 0 0 0 0 0 P48634 PRC2A_HUMAN Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) PRRC2A BAT2 G2 Homo sapiens (Human) cell differentiation [GO:0030154] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] RNA binding [GO:0003723] LDEKFGAPDK;QAARPMR 2 0.8 0.94614 -0.65494 0 0 0 0 0 0 11.5932 11.2074 10.2878 10.2737 0 0 P48637 GSHB_HUMAN Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) GSS Homo sapiens (Human) amino acid metabolic process [GO:0006520]; nervous system development [GO:0007399]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] AIENELLAR;HVGHLLR;LFVDGQEIAVVYFR;TFEDISEKGSLDQDRR 4 9.7 0.23188 0.2966 12.3709 12.377 0 0 0 0 0 10.4777 0 0 14.2487 0 P48643 TCPE_HUMAN T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) CCT5 CCTE KIAA0098 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to virus [GO:0009615] cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] DVDFELIK;IADGYEQAAR;IADGYEQAARVAIEHLDK;TSLGPNGLDK 4 6.7 0.017241 0.70706 0 9.71497 0 0 0 0 0 0 11.4473 12.8971 12.7614 11.6114 P48681 NEST_HUMAN Nestin NES Nbla00170 Homo sapiens (Human) brain development [GO:0007420]; cell projection morphogenesis [GO:0048858]; central nervous system development [GO:0007417]; embryonic camera-type eye development [GO:0031076]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron apoptotic process [GO:0051402]; positive regulation of intermediate filament depolymerization [GO:0030844]; positive regulation of neural precursor cell proliferation [GO:2000179]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111] CCR5 chemokine receptor binding [GO:0031730]; intermediate filament binding [GO:0019215] ALVDQRWREK;DGESDGFADEEESGEEGEEDQEEGR;LGRAVQGAR;SLEEQDQETLR;SLEKENK;SLGAWNLENLR;TLEKETQQR 7 5.1 0.97508 -3.1547 8.53438 0 9.34221 0 0 0 0 0 0 0 4.77879 9.26735 P48728 GCST_HUMAN "Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)" AMT GCST Homo sapiens (Human) glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464] glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483] AAMDFPGAK;AAMDFPGAKVIVPQLKGR 2 4.5 0.9788 -1.9722 0 0 0 0 0 0 8.60485 0 0 0 0 0 P48729 KC1A_HUMAN Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) CSNK1A1 Homo sapiens (Human) cell division [GO:0051301]; cell surface receptor signaling pathway [GO:0007166]; cellular response to nutrient [GO:0031670]; Golgi organization [GO:0007030]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055] beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LESQKAR;LYKILQGGVGIPHIRWYGQEK;QHIPYREDK;TVLMLADQMISR 4 14.5 0.9804 -1.5955 0 0 12.068 0 0 8.7095 8.03094 0 0 0 0 0 P48730 KC1D_HUMAN Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) CSNK1D HCKID Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; COPII vesicle coating [GO:0048208]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; midbrain dopaminergic neuron differentiation [GO:1904948]; non-motile cilium assembly [GO:1905515]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; signal transduction [GO:0007165]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau-protein kinase activity [GO:0050321] EERLRHSR 1 1.9 0.89678 -0.24586 0 0 0 0 0 0 0 0 0 0 0 6.32303 P48735 IDHP_HUMAN "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)" IDH2 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; carbohydrate metabolic process [GO:0005975]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] DIFQEIFDKHYK;DIFQEIFDKHYKTDFDK;LILPHVDIQLK;MAGYLRVVRSLCR;NIPRLVPGWTKPITIGRHAHGDQYK;SPNGTIR;VVRSLCR 7 16.2 0.97455 -3.6643 0 0 0 0 0 0 9.35215 0 0 0 12.113 10.0792 P48736 PK3CG_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)" PIK3CG Homo sapiens (Human) adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cellular response to cAMP [GO:0071320]; dendritic cell chemotaxis [GO:0002407]; endocytosis [GO:0006897]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte apoptotic process [GO:0097284]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell degranulation [GO:0043303]; natural killer cell chemotaxis [GO:0035747]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of triglyceride catabolic process [GO:0010897]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet aggregation [GO:0070527]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cell adhesion mediated by integrin [GO:0033628]; respiratory burst involved in defense response [GO:0002679]; secretory granule localization [GO:0032252]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell proliferation [GO:0042098] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; ephrin receptor binding [GO:0046875]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" GKVQLLYYVNLLLIDHRFLLR;LGPHHFLLLYQK;RIGHFLFWFLRSEIAQSR;VTLDIKSLSAEK 4 5.7 0.97417 -3.0277 0 8.22231 11.5711 0 0 10.2195 0 0 0 0 5.46454 0 P48739 PIPNB_HUMAN Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta) PITPNB Homo sapiens (Human) "lipid metabolic process [GO:0006629]; nucleus organization [GO:0006997]; phospholipid transport [GO:0015914]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; sphingomyelin transfer activity [GO:0140338] ADEDPALFQSVK;GTSAADV;LVTIKFKWWGLQSK 3 12.2 0.89808 -0.23242 0 6.87467 0 0 7.6978 10.3277 0 0 8.94968 0 0 0 P48740 MASP1_HUMAN Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] MASP1 CRARF CRARF1 PRSS5 Homo sapiens (Human) "complement activation, lectin pathway [GO:0001867]; negative regulation of complement activation [GO:0045916]; zymogen activation [GO:0031638]" cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252] QFLQRFPETLMEIEIPIVDHSTCQKAYAPLK 1 4.4 0.64644 0.1708 0 0 0 0 0 0 0 7.42786 0 0 0 0 P48741 HSP77_HUMAN Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) HSPA7 HSP70B Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183] ATAGDTHLGGEDFDNR;KFADTTVQSDMKHWPFQVVSEGGKPK;STLEPVEK;TACERAK;TTPSYVAFTDTER;VEILANDQGNR;VEILANDQGNRTTPSYVAFTDTER 7 22.1 0.87398 -0.10544 0 0 0 0 0 0 0 0 0 9.35927 0 0 P48742 LHX1_HUMAN LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) LHX1 LIM-1 LIM1 Homo sapiens (Human) anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; cerebellum development [GO:0021549]; cervix development [GO:0060067]; comma-shaped body morphogenesis [GO:0072049]; dorsal spinal cord interneuron posterior axon guidance [GO:0097379]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic viscerocranium morphogenesis [GO:0048703]; endoderm formation [GO:0001706]; epithelium development [GO:0060429]; forebrain regionalization [GO:0021871]; gastrulation with mouth forming second [GO:0001702]; head development [GO:0060322]; kidney development [GO:0001822]; lateral motor column neuron migration [GO:0097477]; mesendoderm development [GO:0048382]; mesonephric duct development [GO:0072177]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric glomerulus development [GO:0072224]; metanephric part of ureteric bud development [GO:0035502]; metanephric renal vesicle morphogenesis [GO:0072283]; metanephric S-shaped body morphogenesis [GO:0072284]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct elongation [GO:0035849]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; oviduct development [GO:0060066]; oviduct epithelium development [GO:0035846]; paramesonephric duct development [GO:0061205]; pattern specification process [GO:0007389]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; pronephros development [GO:0048793]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle morphogenesis [GO:0072077]; retina layer formation [GO:0010842]; S-shaped body morphogenesis [GO:0072050]; somite rostral/caudal axis specification [GO:0032525]; spinal cord association neuron differentiation [GO:0021527]; telencephalon development [GO:0021537]; transcription by RNA polymerase II [GO:0006366]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]; uterine epithelium development [GO:0035847]; uterus development [GO:0060065]; vagina development [GO:0060068]; ventral spinal cord development [GO:0021517] chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" CVQCCECKCNLTEK;EAGSNENDDQNLGAKR;QLETLKAAFAATPKPTRHIR;VHCAGCK 4 14 0.94566 -0.65257 0 0 0 0 0 0 0 9.24975 4.5864 9.9976 0 0 P48745 CCN3_HUMAN CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH) CCN3 IGFBP9 NOV NOVH Homo sapiens (Human) angiogenesis [GO:0001525]; bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell chemotaxis [GO:0060326]; chondrocyte differentiation [GO:0002062]; endothelial cell chemotaxis [GO:0035767]; endothelial cell-cell adhesion [GO:0071603]; fibroblast migration [GO:0010761]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of SMAD protein signal transduction [GO:0060392]; positive regulation of cell differentiation [GO:0045597]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of ossification [GO:0045778]; regulation of gene expression [GO:0010468]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; smooth muscle cell proliferation [GO:0048659]; type B pancreatic cell proliferation [GO:0044342] axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025] growth factor activity [GO:0008083]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; integrin binding [GO:0005178]; Notch binding [GO:0005112] QSVQSTSFCLRK 1 3.4 0.67166 0.16795 0 0 0 0 0 0 11.8548 0 0 0 0 0 P48751 B3A3_HUMAN Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) SLC4A3 AE3 Homo sapiens (Human) bicarbonate transport [GO:0015701]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential [GO:0086001]; pH reduction [GO:0045851]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride:bicarbonate antiporter activity [GO:0140900]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857] FLGGKAR;HHPEQPYVTK;LEDNPGVRRHLVK;RRYPHYPSDLR;WGKPHVASLSFR 5 4.3 0.97502 -3.1567 0 0 0 0 9.9976 0 0 10.9236 0 7.69118 0 0 P48764 SL9A3_HUMAN Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; phosphatidylinositol binding [GO:0035091]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] KFLSRVLMR 1 1.1 0.97817 -1.5088 0 0 0 0 8.25489 0 0 0 0 0 0 0 P48775 T23O_HUMAN "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" TDO2 TDO Homo sapiens (Human) protein homotetramerization [GO:0051289]; response to nitroglycerin [GO:1904842]; tryptophan catabolic process to acetyl-CoA [GO:0019442]; tryptophan catabolic process to kynurenine [GO:0019441]; tryptophan metabolic process [GO:0006568] cytosol [GO:0005829] "amino acid binding [GO:0016597]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; tryptophan 2,3-dioxygenase activity [GO:0004833]" KLPVEGSEEDKSQTGVNR 1 4.4 0.96316 -1.0834 0 0 0 0 10.6966 0 0 0 0 0 0 0 P48788 TNNI2_HUMAN "Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)" TNNI2 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; positive regulation of DNA-templated transcription [GO:0045893]; relaxation of skeletal muscle [GO:0090076]; skeletal muscle contraction [GO:0003009] cytosol [GO:0005829]; nucleus [GO:0005634]; troponin complex [GO:0005861] actin binding [GO:0003779]; troponin T binding [GO:0031014] DLRDVGDWR;DLRDVGDWRK 2 5.5 0.97339 -1.3773 0 0 0 0 0 0 0 0 8.21573 0 0 0 P48960 AGRE5_HUMAN Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] ADGRE5 CD97 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888] WCPQNSSCVNATACR 1 1.8 0.93821 -0.57706 0 0 0 8.04051 7.95356 0 0 0 0 0 5.57667 8.49077 P48995 TRPC1_HUMAN Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) TRPC1 TRP1 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; melanin biosynthetic process [GO:0042438]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to calcium ion [GO:0051592] cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; signaling receptor binding [GO:0005102]; store-operated calcium channel activity [GO:0015279]; transmembrane transporter binding [GO:0044325]" CLASPALIMLTEEDPILR;YAMFYPRN 2 3.3 0.87404 -0.10826 0 0 0 0 5.95424 0 0 0 0 0 0 13.5095 P49005 DPOD2_HUMAN DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) POLD2 Homo sapiens (Human) DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035] DNA binding [GO:0003677] VPVATYTNSSQPFR 1 3 0.86997 -0.094806 0 0 0 0 0 0 0 0 0 0 10.9535 0 P49069 CAMLG_HUMAN Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) CAMLG CAML GET2 Homo sapiens (Human) B cell homeostasis [GO:0001782]; defense response [GO:0006952]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; receptor recycling [GO:0001881]; signal transduction [GO:0007165]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; membrane [GO:0016020] ubiquitin protein ligase binding [GO:0031625] LLMNSEQRINR 1 3.7 0.88363 -0.1802 0 8.54493 0 0 0 0 0 7.88013 0 0 0 0 P49137 MAPK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) MAPKAPK2 Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA damage response [GO:0006974]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; intracellular signal transduction [GO:0035556]; leukotriene metabolic process [GO:0006691]; macropinocytosis [GO:0044351]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of cellular response to heat [GO:1900034]; regulation of interleukin-6 production [GO:0032675]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EDKERWEDVK;GCLHDKNSDQATWLTRL;VLKEDKER 3 8.1 0.9747 -1.4277 0 0 0 0 0 10.398 0 0 0 8.63829 0 0 P49189 AL9A1_HUMAN "4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]" ALDH9A1 ALDH4 ALDH7 ALDH9 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; carnitine biosynthetic process [GO:0045329]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase (NAD+) activity [GO:0019145]; formaldehyde dehydrogenase (NAD+) activity [GO:0018467]; small molecule binding [GO:0036094] CRILLEAAR;EILDKFTEEVVKQTQR;SPLIIFSDCDMNNAVK;STGTFVVSQPLNYR 4 11.1 0 2.0018 12.5821 7.90581 8.28258 0 0 0 9.09848 0 0 9.26019 0 0 P49189 AL9A1_HUMAN "4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]" ALDH9A1 ALDH4 ALDH7 ALDH9 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; carnitine biosynthetic process [GO:0045329]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase (NAD+) activity [GO:0019145]; formaldehyde dehydrogenase (NAD+) activity [GO:0018467]; small molecule binding [GO:0036094] AGLAALSPLLR;CRILLEAAR;EILDKFTEEVVKQTQR;SPLIIFSDCDMNNAVK 4 10 0.8981 -0.23528 0 0 0 0 0 0 0 0 0 6.72751 0 0 P49190 PTH2R_HUMAN Parathyroid hormone 2 receptor (PTH2 receptor) PTH2R PTHR2 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cold-induced thermogenesis [GO:0120162] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046] ATLADAR;MVLISGK 2 2.5 0.93778 -0.57053 0 0 0 10.8419 0 10.8453 0 0 12.895 0 10.037 0 P49207 RL34_HUMAN Large ribosomal subunit protein eL34 (60S ribosomal protein L34) RPL34 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; synapse [GO:0045202] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AFLIEEQK;IVYLYTK;LSRTPGNRIVYLYTK;LSYNTASNK;VGKAPKSACGVCPGR 5 40.2 0.15043 0.35027 0 10.7426 8.93973 0 9.62821 0 0 0 0 9.94609 11.5789 0 P49221 TGM4_HUMAN Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4) TGM4 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794] metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] AVGQDRR;AVGQDRRR;KGDIFIVYDTR 3 2.8 0.98005 -1.826 0 0 0 0 0 0 0 5.92529 0 0 0 0 P49257 LMAN1_HUMAN Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) LMAN1 ERGIC53 F5F8D Homo sapiens (Human) blood coagulation [GO:0007596]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of organelle organization [GO:0010638]; protein folding [GO:0006457]; protein transport [GO:0015031] collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; sarcomere [GO:0030017] D-mannose binding [GO:0005537]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] AGSRQRGLR;DIDNLVQR;EPPTPDKEISEKEK;NKPYPVR 4 7.5 0.97605 -2.3356 0 0 0 5.85878 0 0 11.6138 0 0 0 0 0 P49281 NRAM2_HUMAN Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20 Homo sapiens (Human) cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; detection of oxygen [GO:0003032]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; vanadium ion transport [GO:0015676] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; paraferritin complex [GO:0070826]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773] cadmium ion binding [GO:0046870]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; iron ion transmembrane transporter activity [GO:0005381]; lead ion transmembrane transporter activity [GO:0015094]; manganese ion transmembrane transporter activity [GO:0005384]; nickel cation transmembrane transporter activity [GO:0015099]; retromer complex binding [GO:1905394]; solute:proton symporter activity [GO:0015295]; transition metal ion transmembrane transporter activity [GO:0046915]; vanadium ion transmembrane transporter activity [GO:0015100]; zinc ion transmembrane transporter activity [GO:0005385] ISIPEEEYSCFSFR;ISIPEEEYSCFSFRK;LGVVTGLHLAEVCHRQYPK;QLKTEAAPHCELKSYSK;QVNRNNKQEVR 5 10.5 0.9621 -1.0692 0 0 12.2177 10.5153 8.51215 0 13.7749 0 13.498 11.0882 0 0 P49321 NASP_HUMAN Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) blastocyst development [GO:0001824]; CENP-A containing chromatin assembly [GO:0034080]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone binding [GO:0042393]; protein-containing complex binding [GO:0044877] ESQRSGNVAELALK;IEDAKESQR;MAVLNEQVK;QGEVIVSIEEKPK;SGNVAELALK;SIEVIENR 6 6.2 0.0067416 1.1933 0 11.796 12.3349 0 0 9.07449 10.9895 12.2143 12.7593 0 12.1511 0 P49326 FMO5_HUMAN Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) FMO5 Homo sapiens (Human) lipid metabolic process [GO:0006629]; NADPH oxidation [GO:0070995]; regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "aldehyde oxidase activity [GO:0004031]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]" KRIAVIGGGVSGLSSIK 1 3.2 0.5398 0.18539 0 3.55139 0 0 0 0 0 0 0 0 0 0 P49327 FAS_HUMAN Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; establishment of endothelial intestinal barrier [GO:0090557]; ether lipid biosynthetic process [GO:0008611]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; fatty-acyl-CoA biosynthetic process [GO:0046949]; glandular epithelial cell development [GO:0002068]; inflammatory response [GO:0006954]; mammary gland development [GO:0030879]; modulation by host of viral process [GO:0044788]; monocyte differentiation [GO:0030224]; neutrophil differentiation [GO:0030223]; osteoblast differentiation [GO:0001649] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; cadherin binding [GO:0045296]; enoyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0141148]; fatty acid synthase activity [GO:0004312]; fatty acyl-[ACP] hydrolase activity [GO:0016297]; phosphopantetheine binding [GO:0031177]; RNA binding [GO:0003723] AAEQYTPK;DPSQQELPR;FPQLDSTSFANSR;GLVQALQTK;GTPLISPLIK;GYAVLGGER;HIGKVVVQVLAEEPEAVLKGAKPK;LPEDPLLSGLLDSPALK;LQASVRCLATHGR;LQVVDQPLPVR;LSPDAIPGK;QAHTMDPQLR;QELSFAAR;QEPLLIGSTK;RQQEQQVPILEK;SEGVVAVLLTK;SLLVNPEGPTLMR;VGDPQELNGITR;VLEALLPLK;VTQQGLK;YSGTLNLDR 21 9.3 0 24.817 14.8361 12.9482 13.3512 9.39208 8.43521 8.62476 9.8867 9.54797 10.623 11.6782 11.7462 5.62737 P49336 CDK8_HUMAN Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) CDK8 Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of transcription by RNA polymerase II [GO:0045944] CKM complex [GO:1990508]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] DWEDIKK;ERVEDLFEYEGCKVGR;VGRGTYGHVYKAK 3 7.1 0.97627 -1.4682 0 0 0 0 0 0 0 9.716 0 0 5.07579 0 P49354 FNTA_HUMAN Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA Homo sapiens (Human) peptide pheromone maturation [GO:0007323]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of tubulin deacetylation [GO:0090044]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179] CAAX-protein geranylgeranyltransferase complex [GO:0005953]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; protein farnesyltransferase complex [GO:0005965] alpha-tubulin binding [GO:0043014]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein farnesyltransferase activity [GO:0004660]; protein geranylgeranyltransferase activity [GO:0004661]; Rab geranylgeranyltransferase activity [GO:0004663]; receptor tyrosine kinase binding [GO:0030971] LTRDAIELNAANYTVWHFRR 1 5.3 0.95858 -1.0055 0 0 0 0 0 0 0 0 9.20256 0 0 0 P49356 FNTB_HUMAN Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB Homo sapiens (Human) lipid metabolic process [GO:0006629]; protein farnesylation [GO:0018343] cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; protein farnesyltransferase complex [GO:0005965] protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270] LVLQREKHFHYLK;VEEKIQEVFSSYK 2 5.9 0.97897 -1.5319 0 11.1343 0 12.8016 0 0 0 0 0 0 0 0 P49368 TCPG_HUMAN T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) CCT3 CCTG TRIC5 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] ANITAIR;AVAQALEVIPR;ELGIWEPLAVKLQTYK;IGDEYFTFITDCKDPK;IVLLDSSLEYK;NVLLDPQLVPGGGASEMAVAHALTEK;QGGAPDAGQE;TAVETAVLLLR;VQSGNINAAK 9 21.7 0 25.038 13.157 12.1636 11.8761 0 7.68692 7.66527 6.97602 12.5139 10.8343 11.0839 12.8264 7.26162 P49406 RM19_HUMAN "Large ribosomal subunit protein bL19m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (39S ribosomal protein L19, mitochondrial) (L19mt) (MRP-L19)" MRPL19 KIAA0104 MRPL15 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleus [GO:0005634] structural constituent of ribosome [GO:0003735] MAACIAAGHWAAMGLGR;VTTADPYASGK 2 9.6 0.90737 -0.30343 0 9.74362 9.39909 0 0 0 0 0 0 10.4156 0 0 P49407 ARRB1_HUMAN Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) ARRB1 ARR1 Homo sapiens (Human) G protein-coupled receptor internalization [GO:0002031]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601] chromatin [GO:0000785]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] angiotensin receptor binding [GO:0031701]; arrestin family protein binding [GO:1990763]; enzyme inhibitor activity [GO:0004857]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; insulin-like growth factor receptor binding [GO:0005159]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] KASPNGK;VKLVVSR 2 3.3 0.86985 -0.096513 0 9.91801 0 0 0 0 15.5491 15.5746 15.7717 0 0 10.3674 P49411 EFTU_HUMAN "Elongation factor Tu, mitochondrial (EF-Tu) (P43)" TUFM Homo sapiens (Human) mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471]; translational elongation [GO:0006414] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] AEAGDNLGALVR;GITINAAHVEYSTAAR;GTVVTGTLER;LLDAVDTYIPVPAR;TTLTAAITK;TVVTGIEMFHK 6 15.8 0 8.9886 12.3745 11.9122 12.6488 11.3937 9.942 10.1708 0 11.524 10.5038 10.1141 0 0 P49418 AMPH_HUMAN Amphiphysin AMPH AMPH1 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; synaptic vesicle endocytosis [GO:0048488] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] phospholipid binding [GO:0005543] ADIKTGIFAK;GLFPENFTR;GPPVPPLPKVTPTK;LNRAQEKVLQK;NVSSLEAK;NVSSLEAKFHK 6 7.9 0.97441 -2.4377 9.8799 8.66391 8.5547 0 9.08722 0 0 0 0 0 5.68963 0 P49419 AL7A1_HUMAN Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) ALDH7A1 ATQ1 Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase (NAD+) activity [GO:0008802]; identical protein binding [GO:0042802]; L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043] DLPLAQGIKFQ;MIGGPILPSER;NEEEVFAWNNEVK;QGLSSSIFTK;QVGLMVQER 5 10 0.96565 -1.2456 0 0 12.4143 9.83782 5.10388 0 0 0 0 0 0 0 P49448 DHE4_HUMAN "Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3)" GLUD2 GLUDP1 Homo sapiens (Human) glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamate metabolic process [GO:0006536] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; L-leucine binding [GO:0070728] ALASLMTYK;DDGSWEVIEGYR;FTMELAK;HGGTIPIVPTAEFQDSISGASEK;IIAEGANGPTTPEADKIFLER;TAAYVNAIEK;YNLGLDLR;YSTDVSVDEVK 8 18.1 0.70125 0.16126 0 0 0 0 0 0 0 0 10.2743 0 0 0 P49454 CENPF_HUMAN Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin) CENPF Homo sapiens (Human) cell differentiation [GO:0030154]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; protein transport [GO:0015031]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to xenobiotic stimulus [GO:0009410]; ventricular system development [GO:0021591] "axoneme [GO:0005930]; centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]" chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] EMSSIISLNK;ERFLDVENELSRIR;EVCHLEAELK;LEADQSPK;LNVSKALEAALVEK;LQLLSNEIMDK;LSESDYEK;LSSGQNK;LTSVTLEMESK;NIKQCLNQSQNFAEEMKAK;NSVKERESER;QGQLSELDK;QTEQLSLELEVAR;SECITATRK;TQIEEMARSLK;TTALDQLSEKMKEK;VETEQAEIQELKK;VREEIAEYQLRLHEAEK;YCSLLISHEK 19 7 0.9782 -7.8214 0 9.50875 8.9377 9.96924 3.07649 11.5575 12.3268 12.9269 11.5957 11.1237 0 11.4975 P49585 PCY1A_HUMAN Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) PCYT1A CTPCT PCYT1 Homo sapiens (Human) B cell proliferation [GO:0042100]; CDP-choline pathway [GO:0006657]; isotype switching [GO:0045190]; phosphatidylcholine biosynthetic process [GO:0006656] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycogen granule [GO:0042587]; nuclear envelope [GO:0005635]; nucleus [GO:0005634] calmodulin binding [GO:0005516]; choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; protein homodimerization activity [GO:0042803] DAQCSAKVNAR;ELNVSFINEK;MLQAISPKQSPSSSPTRER 3 10.9 0.97525 -1.4422 0 0 0 0 0 0 0 0 4.22002 0 0 0 P49588 SYAC_HUMAN "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42)" AARS1 AARS Homo sapiens (Human) alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of hippo signaling [GO:0035332]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634] alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; peptide lactyltransferase (ATP-dependent) activity [GO:0141207]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] AANTQKCIR;AVFDETYPDPVR;GAMSTQQIK;IVAVTGAEAQK;MDSTLTASEIR;SIDTGMGLER;VGDQVWLFIDEPR 7 7.7 0 7.8561 13.458 13.0495 12.4079 0 10.4722 9.57605 11.4655 9.46734 10.4017 12.1007 10.9896 0 P49590 SYHM_HUMAN "Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)" HARS2 HARSL HARSR HO3 Homo sapiens (Human) histidyl-tRNA aminoacylation [GO:0006427]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] AHQEKPNFIIKTPK;CQSQVAEAVLTSQLK;YDLTVPFAR 3 7.5 0.95487 -0.94516 0 0 0 0 8.62994 0 0 0 0 0 0 9.60077 P49591 SYSC_HUMAN "Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" SARS1 SARS SERS Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor production [GO:1904046]; selenocysteine incorporation [GO:0001514]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; selenocysteine-tRNA ligase activity [GO:0098619]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049] DEWLRPEDLPIK;GYFLKGVLVFLEQALIQYALRTLGSR;LLIDEAILK;YLIATSEQPIAALHR 4 12.1 0.89703 -0.23604 0 0 0 0 6.39703 0 10.3773 0 0 6.71149 0 6.32312 P49593 PPM1F_HUMAN Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2) PPM1F KIAA0015 POPX2 Homo sapiens (Human) cellular response to xenobiotic stimulus [GO:0071466]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein transport [GO:0051224]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AYFAVFDGHGGVDAARYAAVHVHTNAAR;VAEELVAAAR 2 8.4 0.90986 -0.28311 0 4.24823 0 0 0 0 0 0 0 9.69664 0 0 P49619 DGKG_HUMAN Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) DGKG DAGK3 Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of phospholipase C/protein kinase C signal transduction [GO:0160195]; neuron development [GO:0048666]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; regulation of dendrite development [GO:0050773] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289] SIKCYQSVTARHCVWCR 1 2.1 0.48524 0.19005 0 0 0 7.17413 0 0 0 0 0 0 0 0 P49639 HXA1_HUMAN Homeobox protein Hox-A1 (Homeobox protein Hox-1F) HOXA1 HOX1F Homo sapiens (Human) abducens nerve formation [GO:0021599]; anatomical structure morphogenesis [GO:0009653]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; cognition [GO:0050890]; embryonic neurocranium morphogenesis [GO:0048702]; inner ear development [GO:0048839]; neuromuscular process [GO:0050905]; optokinetic behavior [GO:0007634]; outer ear morphogenesis [GO:0042473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of behavior [GO:0050795]; regulation of transcription by RNA polymerase II [GO:0006357]; semicircular canal formation [GO:0060876]; sensory perception of sound [GO:0007605] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ITTFQSCAVSANSCGGDDR 1 5.7 0.783 0.028677 0 0 8.11187 0 0 0 0 0 0 0 0 8.07178 P49641 MA2A2_HUMAN "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]" NLGATPR;SIRRVDEEHEQQVD;TLPSSVRIYLHGR 3 4.3 0.98005 -2.0116 0 0 0 0 0 6.16175 0 0 0 9.07802 0 0 P49642 PRI1_HUMAN DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) PRIM1 Homo sapiens (Human) "DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]" alpha DNA polymerase:primase complex [GO:0005658]; membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA primase activity [GO:0003896]; magnesium ion binding [GO:0000287]; ribonucleotide binding [GO:0032553]; zinc ion binding [GO:0008270] CWTLMTMAIRIIDRALK;LDINVSK 2 5.7 0.84132 -0.045407 0 0 0 0 0 0 5.82757 0 0 6.13346 6.66121 0 P49662 CASP4_HUMAN Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] CASP4 ICH2 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to amyloid-beta [GO:1904646]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; NLRP1 inflammasome complex [GO:0072558]; non-canonical inflammasome complex [GO:0160074]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; cysteine-type endopeptidase activity [GO:0004197]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530] YSWCCHLEEVFR 1 3.2 0.80792 0.010509 0 0 0 0 3.54918 0 0 0 0 0 0 0 P49675 STAR_HUMAN "Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1)" STAR STARD1 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; glucocorticoid metabolic process [GO:0008211]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; regulation of steroid biosynthetic process [GO:0050810]; steroid biosynthetic process [GO:0006694] mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] RLESHPASEAR;RRSSLLGSR 2 7 0.71325 0.14648 0 0 5.99634 0 0 6.68552 9.51924 0 0 0 0 0 P49682 CXCR3_HUMAN C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) CXCR3 GPR9 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell adhesion [GO:0030155]; regulation of leukocyte migration [GO:0002685] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023] ERMWMLLLR 1 2.4 0.93287 -0.50111 0 0 0 0 0 6.86703 0 0 0 0 0 0 P49683 PRLHR_HUMAN Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3) PRLHR GPR10 GR3 Homo sapiens (Human) feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone metabolic process [GO:0042445] cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983] QLYAWGLLLVTYLLPLLVILLSYVRVSVKLR 1 8.4 0.66841 0.1687 0 0 0 0 0 0 0 0 0 0 4.6744 0 P49685 GPR15_HUMAN G-protein coupled receptor 15 (Brother of Bonzo) (BoB) GPR15 Homo sapiens (Human) angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; symbiont entry into host cell [GO:0046718]; T cell migration [GO:0072678] cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; virus receptor activity [GO:0001618] ALSTFIHAEDFARRR;MDPEETSVYLDYYYATSPNSDIR 2 10.6 0.15165 0.35002 10.1762 0 0 0 0 0 7.3077 0 0 8.44348 0 0 P49703 ARL4D_HUMAN ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L) ARL4D ARF4L Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LRPLWRSYTR 1 5 0.97993 -1.5688 0 0 11.1585 0 0 0 0 0 0 0 0 0 P49711 CTCF_HUMAN Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Homo sapiens (Human) "cardiac muscle cell development [GO:0055013]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; epigenetic regulation of gene expression [GO:0040029]; gene expression [GO:0010467]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromosome, centromeric region [GO:0071459]; regulation of centromeric sister chromatid cohesion [GO:0070602]" "chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "chromatin insulator sequence binding [GO:0043035]; chromatin loop anchoring activity [GO:0140587]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" KTFQCELCSYTCPR;QKQLLDMHFK;QLLDMHFK 3 3.3 0.98034 -1.8035 0 0 0 9.41908 0 0 9.41766 0 0 0 9.67657 0 P49715 CEBPA_HUMAN CCAAT/enhancer-binding protein alpha (C/EBP alpha) CEBPA CEBP Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; DNA-templated transcription [GO:0006351]; embryonic placenta development [GO:0001892]; energy homeostasis [GO:0097009]; epithelial cell maturation [GO:0002070]; fat cell differentiation [GO:0045444]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; interleukin-6-mediated signaling pathway [GO:0070102]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; lung development [GO:0030324]; macrophage differentiation [GO:0030225]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage activation [GO:0043032]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase I [GO:0006360]; urea cycle [GO:0000050]; white fat cell differentiation [GO:0050872] C/EBP complex [GO:1990647]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; RNA polymerase I transcription regulatory region sequence-specific DNA binding [GO:0001163]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]" AGSPGGRR;ASGGSGAGK 2 4.3 0.95548 -0.79204 0 0 11.3636 0 0 0 0 0 0 0 0 0 P49716 CEBPD_HUMAN CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) CEBPD Homo sapiens (Human) fat cell differentiation [GO:0045444]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NQEMQQK;VEQLTRDLAGLR 2 7.1 0.96298 -1.0998 0 0 9.98982 0 0 0 0 0 0 0 0 0 P49720 PSB3_HUMAN Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome subunit beta-3) (beta-3) (Proteasome theta chain) PSMB3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" DAVSGMGVIVHIIEK;FGIQAQMVTTDFQK;MSIMSYNGGAVMAMKGK;SIMSYNGGAVMAMK 4 22.4 0.98066 -1.6266 0 0 11.3978 10.5072 3.93197 0 0 0 7.77827 0 0 0 P49721 PSB2_HUMAN Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4) PSMB2 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to organic cyclic compound [GO:0014070] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" FILNLPTFSVR;NGYELSPTAAANFTR 2 12.9 0 3.2002 0 0 0 0 0 0 8.51033 0 0 0 9.6319 0 P49736 MCM2_HUMAN DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) MCM2 BM28 CCNL1 CDCL1 KIAA0030 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cochlea development [GO:0090102]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; nucleosome assembly [GO:0006334]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytoplasm [GO:0005737]; MCM complex [GO:0042555]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA replication origin binding [GO:0003688]; double-stranded DNA helicase activity [GO:0036121]; enzyme binding [GO:0019899]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] DTVDPVQDEMLAR;ESLVVNYEDLAAR;GLALALFGGEPK;IQESPGK;ISHLPLVEELR;ISHLPLVEELRSLR;MNKFSHDLKR;VAAGRLPR 8 8.5 0.78443 0.027108 0 11.191 10.9228 0 9.8182 0 5.98766 10.5442 11.4937 9.7288 9.40301 0 P49746 TSP3_HUMAN Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] LGFLGNQSQGCLPAR;VLVRYQREDGK;VPNPLQTDR;YQREDGK 4 3.7 0.97883 -2.0584 0 0 0 0 0 0 9.89143 0 10.6965 0 0 12.1706 P49747 COMP_HUMAN Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5) COMP Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; BMP signaling pathway [GO:0030509]; bone mineralization [GO:0030282]; cartilage homeostasis [GO:1990079]; cellular senescence [GO:0090398]; chondrocyte development [GO:0002063]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; growth plate cartilage development [GO:0003417]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hemostasis [GO:1900047]; platelet aggregation [GO:0070527]; positive regulation of chondrocyte proliferation [GO:1902732]; protein homooligomerization [GO:0051260]; protein processing [GO:0016485]; protein secretion [GO:0009306]; regulation of bone mineralization [GO:0030500]; regulation of gene expression [GO:0010468]; response to unfolded protein [GO:0006986]; skeletal system development [GO:0001501]; skin development [GO:0043588]; tendon development [GO:0035989]; vascular associated smooth muscle cell development [GO:0097084]; vascular associated smooth muscle contraction [GO:0014829] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394] GDACDDDIDGDR 1 1.7 0.80999 0.0064273 0 0 0 4.65753 0 3.90814 5.19176 0 0 0 7.14924 0 P49748 ACADV_HUMAN "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)" ACADVL VLCAD Homo sapiens (Human) energy derivation by oxidation of organic compounds [GO:0015980]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; regulation of cholesterol metabolic process [GO:0090181]; response to cold [GO:0009409]; temperature homeostasis [GO:0001659] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] acyl-CoA dehydrogenase activity [GO:0003995]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099] ALEQFATVVEAK;IFEGTNDILR;LGGGSSR;MAASLGR 4 5.5 0.01227 0.86613 0 0 0 7.46548 6.77873 0 0 11.5161 11.4804 10.5697 9.27854 0 P49750 YLPM1_HUMAN YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113) YLPM1 C14orf170 ZAP3 Homo sapiens (Human) regulation of telomere maintenance [GO:0032204] nuclear speck [GO:0016607]; nucleus [GO:0005634] RNA binding [GO:0003723] DQLQEYEK;DQLQEYEKQWKTWQGHMK;DRGVIDYDR;ITDESGHLAEK;LKEINKMADHWETAPR;MLREQKEQLQK;RVRWADLEEK;VEQIPYGER;VHLPGHK;VLSLDDYFITEVEKEEK;YDRERDR 11 5.4 0.97533 -4.2678 11.1066 9.36744 0 0 0 0 8.49305 0 8.84897 10.0046 0 0 P49753 ACOT2_HUMAN "Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128)" ACOT2 PTE2 PTE2A Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617] ADTLGELDLER;GETLPPVGVNRNRIK 2 5.4 0.96691 -1.2791 0 0 0 0 0 0 0 0 0 0 8.8563 0 P49754 VPS41_HUMAN Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 Homo sapiens (Human) cellular response to starvation [GO:0009267]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; macroautophagy [GO:0016236]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] IIAVHPHFVRSSCKQFVTGGK;LLLFERSWMNRWK 2 4 0.98228 -1.5855 0 0 8.03573 0 6.95791 0 0 0 0 0 0 0 P49756 RBM25_HUMAN RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EMEADER;EMEADERDR;IIEYIGEEEATLVDFVCSK;LPVDSVFNK 4 4.4 0.95893 -1.0408 0 0 6.15413 0 0 0 0 0 5.57664 0 8.35191 0 P49757 NUMB_HUMAN Protein numb homolog (h-Numb) (Protein S171) NUMB C14orf41 Homo sapiens (Human) adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; lateral ventricle development [GO:0021670]; negative regulation of protein localization to plasma membrane [GO:1903077]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of cell migration [GO:0030335]; positive regulation of neurogenesis [GO:0050769]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] AFSYICRDGTTRR;AVKAVLWVSADGLRVVDEK;VVDEKTKDLIVDQTIEK 3 6.8 0.24052 0.28985 0 0 8.79951 0 0 9.22697 2.94505 0 0 0 7.77709 0 P49758 RGS6_HUMAN Regulator of G-protein signaling 6 (RGS6) (S914) RGS6 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] DQFLRFLESEFSSENLR;LKNPQKVK 2 5.3 0.87392 -0.11657 0 0 6.89869 0 0 0 0 0 0 7.289 0 0 P49760 CLK2_HUMAN Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212] nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] LTLGEALQHPFFARLR;YEIVSTLGEGTFGR 2 6 0.8848 -0.18124 0 0 0 10.2213 0 0 0 0 11.1754 0 0 0 P49761 CLK3_HUMAN Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) CLK3 Homo sapiens (Human) protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484] acrosomal vesicle [GO:0001669]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; RNA binding [GO:0003723] HAHHCHK;IIRNVGK;TRSCSSASSR;YRSPEPDPYLSYRWK 4 8 0.98095 -1.7351 0 0 9.54639 6.19969 0 10.0509 0 0 0 0 10.9661 0 P49765 VEGFB_HUMAN Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF) VEGFB VRF Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; coronary vasculature development [GO:0060976]; induction of positive chemotaxis [GO:0050930]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular wound healing [GO:0035470]; protein O-linked glycosylation [GO:0006493]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor binding [GO:0005172] VVSWIDVYTR 1 5.3 0.89716 -0.23049 11.964 0 0 0 0 0 0 0 0 0 0 0 P49770 EI2BB_HUMAN Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta) EIF2B2 EIF2BB Homo sapiens (Human) central nervous system development [GO:0007417]; cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translational initiation [GO:0006446]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] MPGSAAK 1 2 0.6893 0.16248 0 0 0 9.12707 0 0 0 0 0 0 0 0 P49773 HINT1_HUMAN Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) HINT1 HINT PKCI1 PRKCNH1 Homo sapiens (Human) intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of calcium-mediated signaling [GO:0050850]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508]; purine ribonucleotide catabolic process [GO:0009154]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenosine 5'-monophosphoramidase activity [GO:0043530]; deSUMOylase activity [GO:0016929]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; protein kinase C binding [GO:0005080] AQVARPGGDTIFGK;IIFEDDR;MADEIAKAQVARPGGDTIFGK 3 22.2 0.0048309 1.5686 0 0 12.1745 0 0 0 0 0 0 13.8387 0 0 P49789 FHIT_HUMAN "Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)" FHIT Homo sapiens (Human) diadenosine triphosphate catabolic process [GO:0015964]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; purine nucleotide metabolic process [GO:0006163] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenosine 5'-monophosphoramidase activity [GO:0043530]; adenylylsulfatase activity [GO:0047627]; adenylylsulfate-ammonia adenylyltransferase activity [GO:0047352]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; ubiquitin protein ligase binding [GO:0031625] SEEEMAAEAAALR 1 8.8 0.93654 -0.54776 0 0 0 0 0 0 0 0 12.0861 0 0 0 P49790 NU153_HUMAN Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) NUP153 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; symbiont entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056] ADNEEPK;RILQSLEK 2 1 0.88955 -0.205 11.1645 7.14832 0 0 0 8.15431 0 6.82426 0 0 0 0 P49792 RBP2_HUMAN E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) RANBP2 NUP358 Homo sapiens (Human) centrosome localization [GO:0051642]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO ligase complex [GO:0106068] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789] AKYWLER;AVVSPPK;DLVLKIAELLCK;DVGQWKER;EPELEDLTRYDVGAIR;EQVLKICANHYISPDMK;EYIGRSVHYWK;FDVESKEWK;FLGLLYELEENTDK;GEAGQNLLEMMACDR;ITITECGQI;ITMELFSNIVPR;KCELSKNSDIEQSSDSK;KQSLPATSIPTPASFK;LRLLVQHEINTLR;QKSWWDAVCTLIHR;QLCTERQKSWWDAVCTLIHR;VLPLLKIIK;YDVGAIR;YSLSPSKSYK 20 6.9 0.9781 -8.2913 11.9227 7.84568 8.06641 8.80974 9.84786 6.79168 8.97931 9.15196 10.2363 10.8093 7.47143 6.1766 P49795 RGS19_HUMAN Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) RGS19 GAIP GNAI3IP Homo sapiens (Human) autophagy [GO:0006914]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to ethanol [GO:0045471]; small GTPase-mediated signal transduction [GO:0007264] brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; GTPase activity [GO:0003924] NPCCLCWCCCCSCSWNQER;NPCCLCWCCCCSCSWNQERR 2 9.2 0.07329 0.41815 0 0 0 0 0 0 0 0 6.0295 0 5.69725 0 P49796 RGS3_HUMAN Regulator of G-protein signaling 3 (RGP3) (RGS3) RGS3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] DEWTQTSPARK;ELGRNGGSMHHLSLFFTGHR;LDSTYSQK;LGIFRRR;RDEWTQTSPAR;VLLLHIIEGKGLISK 6 5.2 0.97588 -1.4848 0 0 0 0 0 0 12.6889 0 0 10.207 8.56396 0 P49796 RGS3_HUMAN Regulator of G-protein signaling 3 (RGP3) (RGS3) RGS3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] HHLSLFFTGHRK;LGIFRRR 2 9.2 0.87344 -0.11399 0 0 0 10.4896 0 0 0 0 0 0 0 0 P49796 RGS3_HUMAN Regulator of G-protein signaling 3 (RGP3) (RGS3) RGS3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] GVGDRSQSGASYRPICGPK;LGIFRRR 2 8.4 0.91566 -0.43186 0 0 13.4628 0 0 0 4.61559 0 0 0 0 0 P49798 RGS4_HUMAN Regulator of G-protein signaling 4 (RGP4) (RGS4) RGS4 Homo sapiens (Human) dorsal root ganglion development [GO:1990791]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of heart rate [GO:0010460]; regulation of actin filament organization [GO:0110053]; regulation of calcium ion transport [GO:0051924]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] GLAGLPASCLR;IYNEFISVQATKEVNLDSCTREETSR 2 12.3 0.8484 -0.067195 0 11.1157 6.70238 0 0 0 0 0 0 0 9.31411 0 P49802 RGS7_HUMAN Regulator of G-protein signaling 7 (RGS7) RGS7 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of GTPase activity [GO:0043547]; positive regulation of potassium ion transmembrane transport [GO:1901381]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471] cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] NLTIEDPAVYLCKR;SSAYQELLQAK 2 5.9 0.86988 -0.10078 0 0 0 4.86849 0 0 12.7795 0 0 0 0 0 P49810 PSN2_HUMAN Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] PSEN2 AD4 PS2 PSNL2 STM2 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; calcium ion homeostasis [GO:0055074]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]; regulation of calcium import into the mitochondrion [GO:0110097]; response to hypoxia [GO:0001666] centrosome [GO:0005813]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" AAATGSGDWNTTLACFVAILIGLCLTLLLLAVFK;HVIMLFVPVTLCMIVVVATIK;LLNSVLNTLIMISVIVVMTIFLVVLYK 3 18.3 0.050788 0.48747 0 0 0 0 0 4.14413 9.78937 7.52912 6.90014 0 0 0 P49815 TSC2_HUMAN Tuberin (Tuberous sclerosis 2 protein) TSC2 TSC4 Homo sapiens (Human) anoikis [GO:0043276]; cellular response to starvation [GO:0009267]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596] GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] LGVLRALFFKVIK;TINVKELCEPCWK;TKTWLVGNK;VLLQCLKQESDWKVLK 4 2.8 0.92383 -0.44914 0 0 0 9.64436 0 0 6.644 0 0 3.99213 0 10.5782 P49821 NDUV1_HUMAN "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)" NDUFV1 UQOR1 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" AAYIYIR;LLGWSLPARTAPK 2 4.4 0.91136 -0.28659 0 0 6.32937 0 0 0 6.66761 0 0 0 0 0 P49841 GSK3B_HUMAN Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) GSK3B Homo sapiens (Human) beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to interleukin-3 [GO:0036016]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; epithelial to mesenchymal transition [GO:0001837]; ER overload response [GO:0006983]; establishment of cell polarity [GO:0030010]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; glycogen metabolic process [GO:0005977]; heart valve development [GO:0003170]; hippocampus development [GO:0021766]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC2 signaling [GO:1903940]; negative regulation of type B pancreatic cell development [GO:2000077]; neuron projection development [GO:0031175]; neuron projection organization [GO:0106027]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cilium assembly [GO:0045724]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein-containing complex assembly [GO:0031334]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of axonogenesis [GO:0050770]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of dendrite morphogenesis [GO:0048814]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of microtubule anchoring at centrosome [GO:0150101]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection development [GO:0010975]; regulation of protein export from nucleus [GO:0046825]; superior temporal gyrus development [GO:0071109]; viral protein processing [GO:0019082] axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Wnt signalosome [GO:1990909] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; beta-catenin binding [GO:0008013]; DNA-dependent protein kinase activity [GO:0004677]; dynactin binding [GO:0034452]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; scaffold protein binding [GO:0097110]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin protein ligase binding [GO:0031625] VLGTPTR 1 1.7 0.55412 0.1831 0 0 0 0 0 0 0 0 10.5919 0 0 0 P49842 STK19_HUMAN Inactive serine/threonine-protein kinase 19 (Protein G11) (Protein RP1) STK19 G11 RP1 Homo sapiens (Human) positive regulation of Ras protein signal transduction [GO:0046579]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FSSLHSYPFPGTIKSRDMSWK 1 5.8 0.86351 -0.083824 7.89373 0 0 0 0 0 0 0 0 0 0 0 P49848 TAF6_HUMAN Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) TAF6 TAF2E TAFII70 Homo sapiens (Human) apoptotic process [GO:0006915]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] FASGGGR 1 1 0.6989 0.16173 9.15717 0 0 0 8.72564 0 10.6206 0 0 7.79812 6.70833 0 P49862 KLK7_HUMAN Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE) KLK7 PRSS6 SCCE Homo sapiens (Human) epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; protein maturation [GO:0051604]; proteolysis [GO:0006508] cornified envelope [GO:0001533]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LNSQARLSSMVK 1 4.7 0.92398 -0.44857 0 0 0 0 0 0 0 0 0 8.68373 0 0 P49888 ST1E1_HUMAN "Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)" SULT1E1 STE Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] ENLMNGVKQLDEMNSPR;LSPFMRK 2 8.2 0.91684 -0.40971 0 0 0 0 0 0 0 0 11.4257 10.8504 0 0 P49895 IOD1_HUMAN Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) DIO1 ITDI1 TXDI1 Homo sapiens (Human) amino acid metabolic process [GO:0006520]; hormone biosynthetic process [GO:0042446]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800] LSGQRCNIWEFMQDGWAFK;RLWVLLEVAVHVVVGK 2 17.4 0.91961 -0.43783 0 0 0 0 0 0 0 0 0 0 8.11889 0 P49895 IOD1_HUMAN Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) DIO1 ITDI1 TXDI1 Homo sapiens (Human) amino acid metabolic process [GO:0006520]; hormone biosynthetic process [GO:0042446]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800] GSGPKLPGGPPLR;RLWVLLEVAVHVVVGK 2 34.1 0.75874 0.071089 0 0 9.69817 0 0 0 0 0 0 0 8.18923 0 P49902 5NTC_HUMAN Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) NT5C2 NT5B NT5CP PNT5 Homo sapiens (Human) adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]; protein K48-linked ubiquitination [GO:0070936] cytoplasm [GO:0005737]; cytosol [GO:0005829] 5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630]; XMP 5'-nucleosidase activity [GO:0106411] IKKVTHDMDMCYGMMGSLFR;SLAMEKIK 2 5 0.9761 -2.2996 0 0 11.0032 0 0 0 0 0 0 0 0 0 P49903 SPS1_HUMAN "Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1)" SEPHS1 SELD SPS SPS1 Homo sapiens (Human) protein modification process [GO:0036211]; selenocysteine biosynthetic process [GO:0016260] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; selenide, water dikinase activity [GO:0004756]" IIEVAPQVATQNVNPTPGATS;VPQDVLQK 2 7.4 0.88247 -0.17851 0 10.2182 0 0 0 0 0 0 0 0 0 0 P49908 SEPP1_HUMAN Selenoprotein P (SeP) SELENOP SELP SEPP1 Homo sapiens (Human) brain development [GO:0007420]; locomotory behavior [GO:0007626]; post-embryonic development [GO:0009791]; regulation of growth [GO:0040008]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]; sexual reproduction [GO:0019953] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089] selenium binding [GO:0008430] CINQLLCK;HLIFEKTGSAITUQCK;NQAKKUEUPSN;SUCCHCR;SUCCHCRHLIFEK 5 11 0.9659 -1.1265 0 0 5.14645 0 0 0 0 0 0 6.17355 9.0492 0 P49910 ZN165_HUMAN Zinc finger protein 165 (Cancer/testis antigen 53) (CT53) (LD65) (Zinc finger and SCAN domain-containing protein 7) ZNF165 ZPF165 ZSCAN7 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKPYECSECGK;IHTGERCYECNECGK 2 5.4 0.82927 -0.021696 0 0 0 0 0 6.91958 0 0 0 0 0 0 P49915 GUAA_HUMAN GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) GMPS Homo sapiens (Human) GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] cytosol [GO:0005829] ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921] ELGLPEELVSR;IVADFSASVKKPHTLLQRVK;MMNKVFGGTVHKK;SGNIVAGIANESK 4 9.6 0.98001 -1.5588 0 0 0 0 0 0 9.8097 0 0 0 0 10.5501 P49916 DNLI3_HUMAN DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) "base-excision repair, DNA ligation [GO:0006288]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]" DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270] GTAGCKK;KAAVWEITGAEFSK;LLLPGVIKTVYNLNDKQIVK;LSNSNSK;SEAHTADGISIRFPR;SLLTIQEVDEFLLR;SLSSSKCDPR;TVYNLNDK 8 8.6 0.87696 -0.13388 0 10.1846 10.9045 0 6.72806 7.42501 9.10032 12.2224 9.77393 6.24291 6.20406 0 P49917 DNLI4_HUMAN DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) LIG4 Homo sapiens (Human) "cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to ionizing radiation [GO:0071479]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DN2 thymocyte differentiation [GO:1904155]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; fibroblast proliferation [GO:0048144]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; V(D)J recombination [GO:0033151]" "chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; ligase activity [GO:0016874]; magnesium ion binding [GO:0000287] FMIHMCPSTKEHFAR;RHTVYLDSYAVINDLSTK 2 3.6 0.8878 -0.19024 0 0 0 0 9.38868 9.28619 0 0 0 0 0 0 P49959 MRE11_HUMAN Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) MRE11 HNGS1 MRE11A Homo sapiens (Human) cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; homologous chromosome pairing at meiosis [GO:0007129]; homologous recombination [GO:0035825]; meiotic DNA double-strand break formation [GO:0042138]; mitochondrial double-strand break repair via homologous recombination [GO:0097552]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; R-loop processing [GO:0062176]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; sister chromatid cohesion [GO:0007062]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860] "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; cadherin binding [GO:0045296]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] IALYGLGSIPDER;LYRMFVNKK;NMSIIDAFKSTRQQPSR;VTMLRPK 4 6.5 0.978 -2.1311 0 12.5945 0 12.7822 0 9.41445 9.54249 11.2291 0 0 8.90911 0 P49961 ENTP1_HUMAN Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) ENTPD1 CD39 Homo sapiens (Human) blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; nucleoside diphosphate catabolic process [GO:0009134]; platelet aggregation [GO:0070527] caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ADP phosphatase activity [GO:0043262]; apyrase activity [GO:0004050]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; CDP phosphatase activity [GO:0036384]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; CTPase activity [GO:0043273]; DNA clamp loader activity [GO:0003689]; GDP phosphatase activity [GO:0004382]; IDP phosphatase activity [GO:1990003]; ITPase activity [GO:0103023]; membrane scission GTPase motor activity [GO:1990606]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] FLNLTSEK 1 1.6 0.91372 -0.39033 0 0 0 0 10.3689 0 0 0 0 0 0 0 P50052 AGTR2_HUMAN Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor) AGTR2 Homo sapiens (Human) angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002033]; blood vessel remodeling [GO:0001974]; brain development [GO:0007420]; brain renin-angiotensin system [GO:0002035]; cell surface receptor signaling pathway [GO:0007166]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; inflammatory response [GO:0006954]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of heart rate [GO:0010459]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; neuron apoptotic process [GO:0051402]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of metanephric glomerulus development [GO:0072300]; regulation of blood pressure [GO:0008217]; regulation of metanephros size [GO:0035566]; regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991]; vasodilation [GO:0042311] plasma membrane [GO:0005886] angiotensin type II receptor activity [GO:0004945]; receptor antagonist activity [GO:0048019] EMETFVS 1 1.9 0.94147 -0.60275 10.597 0 0 0 0 0 0 0 0 0 0 0 P50053 KHK_HUMAN Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase) KHK Homo sapiens (Human) fructose metabolic process [GO:0006000]; regulation of glycogen metabolic process [GO:0070873]; response to fructose [GO:0009750]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to sucrose [GO:0009744]; response to zinc ion [GO:0010043] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; fructose binding [GO:0070061]; identical protein binding [GO:0042802]; ketohexokinase activity [GO:0004454]; protein homodimerization activity [GO:0042803] SLPDVSATDFEK;TILYYDR 2 6.4 0.95376 -0.92753 9.03127 0 0 0 0 0 0 0 0 0 0 0 P50135 HNMT_HUMAN Histamine N-methyltransferase (HMT) (EC 2.1.1.8) HNMT Homo sapiens (Human) histamine catabolic process [GO:0001695]; histamine metabolic process [GO:0001692]; L-histidine catabolic process [GO:0006548]; methylation [GO:0032259]; respiratory gaseous exchange by respiratory system [GO:0007585] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] histamine N-methyltransferase activity [GO:0046539] DLQEPEFSAKK 1 3.8 0.71497 0.14215 0 0 0 0 0 0 0 0 0 8.97923 0 0 P50213 IDH3A_HUMAN "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)" IDH3A Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] isocitrate dehydrogenase complex (NAD+) [GO:0045242]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] IEAACFATIK;LITEGASK;SNVTAVHK 3 7.1 0.96611 -1.1291 0 0 0 0 0 0 0 0 11.2352 0 0 0 P50225 ST1A1_HUMAN Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) SULT1A1 STP STP1 OK/SW-cl.88 Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] DTPAPRLLK;ILEFVGR;SLPEETVDFVVQHTSFK 3 11.2 0.95238 -0.75912 0 7.15684 0 0 0 0 0 0 0 0 5.47797 0 P50281 MMP14_HUMAN Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) MMP14 Homo sapiens (Human) angiogenesis [GO:0001525]; astrocyte cell migration [GO:0043615]; branching morphogenesis of an epithelial tube [GO:0048754]; cell motility [GO:0048870]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; head development [GO:0060322]; lung development [GO:0030324]; male gonad development [GO:0008584]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GDF15-GFRAL signaling pathway [GO:0160145]; negative regulation of Notch signaling pathway [GO:0045746]; ovarian follicle development [GO:0001541]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage migration [GO:1905523]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein processing [GO:0010954]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of protein localization to plasma membrane [GO:1903076]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to odorant [GO:1990834]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501]; tissue remodeling [GO:0048771]; zymogen activation [GO:0031638] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; intermediate filament cytoskeleton [GO:0045111]; macropinosome [GO:0044354]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] LLYCQRSLLDK;VEPGYPK;VWEGIPESPR 3 4.8 0.97301 -2.6585 0 0 13.9967 0 0 0 0 0 0 0 0 10.7634 P50336 PPOX_HUMAN Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) PPOX Homo sapiens (Human) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660]; menaquinone-dependent protoporphyrinogen oxidase activity [GO:0070819]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729] GVFAGNSRELSIR 1 2.7 0.95327 -0.67416 12.5374 0 0 0 0 0 0 0 0 0 0 0 P50391 NPY4R_HUMAN Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) NPY4R PPYR1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]; peptide hormone binding [GO:0017046] LSGRSNPI 1 2.1 0.91283 -0.33804 0 0 0 0 0 0 0 9.19564 0 0 0 8.52081 P50395 GDIB_HUMAN Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 RABGDIB Homo sapiens (Human) negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]; vesicle [GO:0031982] GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] DLGTESQIFISR;DWNVDLIPK;FLMANGQLVK;FVSISDLLVPK;LYSESLAR;MLLYTEVTR;SEGEIAR;SPYLYPLYGLGELPQGFAR;TFEGIDPK;VEKVGQVIRVICILSHPIK;VTEGSFVYK 11 27.2 0 13.241 12.5139 12.4456 12.1664 9.19899 8.38823 8.47938 12.3552 10.2738 9.34423 0 10.1379 9.04611 P50402 EMD_HUMAN Emerin EMD EDMD STA Homo sapiens (Human) amyloid fibril formation [GO:1990000]; cellular response to growth factor stimulus [GO:0071363]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; nuclear membrane organization [GO:0071763]; positive regulation of protein export from nucleus [GO:0046827]; regulation of canonical Wnt signaling pathway [GO:0060828]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; TMEM240-body [GO:0160045] actin binding [GO:0003779]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296] GDADMYDLPK 1 3.9 0.80352 0.012704 0 0 0 0 0 0 0 0 0 0 0 4.38011 P50416 CPT1A_HUMAN "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-)" CPT1A CPT1 Homo sapiens (Human) aflatoxin metabolic process [GO:0046222]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; glucose metabolic process [GO:0006006]; liver regeneration [GO:0097421]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of innate immune response [GO:0045089]; regulation of insulin secretion [GO:0050796]; regulation of lipid storage [GO:0010883]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to tetrachloromethane [GO:1904772]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674] FSCPETDSHR;LFKLASEKHQHMYR;VPWARCR 3 4 0.97993 -1.8719 0 0 0 0 0 6.73349 0 0 0 0 0 0 P50440 GATM_HUMAN "Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase)" GATM AGAT Homo sapiens (Human) creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; learning or memory [GO:0007611]; muscle atrophy [GO:0014889]; positive regulation of cold-induced thermogenesis [GO:0120162] extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] amidinotransferase activity [GO:0015067]; glycine amidinotransferase activity [GO:0015068] LGITTIK 1 1.7 0.70317 0.16054 0 9.66162 9.6783 0 0 0 0 0 0 0 0 0 P50443 S26A2_HUMAN Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) SLC26A2 DTD DTDST Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; ossification [GO:0001503]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] GVCVPNGLSLSSD 1 1.8 0.89773 -0.2317 0 0 0 0 0 0 0 0 0 0 0 9.7435 P50452 SPB8_HUMAN Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8) SERPINB8 PI8 Homo sapiens (Human) epithelial cell-cell adhesion [GO:0090136]; negative regulation of endopeptidase activity [GO:0010951] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] LFKTNEEK 1 4.2 0.97776 -1.5146 12.9625 10.0193 0 0 0 0 0 0 0 0 0 0 P50453 SPB9_HUMAN Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9) SERPINB9 PI9 Homo sapiens (Human) cellular response to estrogen stimulus [GO:0071391]; immune response [GO:0006955]; mast cell mediated immunity [GO:0002448]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endopeptidase activity [GO:0010951]; protection from natural killer cell mediated cytotoxicity [GO:0042270] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] LTAWTKPDCMK 1 2.9 0.78746 0.017918 0 0 0 0 0 8.24612 0 0 0 0 0 0 P50454 SERPH_HUMAN Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 Homo sapiens (Human) chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; protein maturation [GO:0051604]; response to unfolded protein [GO:0006986] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; membrane raft [GO:0045121] collagen binding [GO:0005518]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; unfolded protein binding [GO:0051082] AATLAER;AVAISLPK;DQAVENILVSPVVVASSLGLVSLGGK;DTQSGSLLFIGR;GVVEVTHDLQK;LEKLLTKEQLK;LSSLIILMPHHVEPLER;LYGPSSVSFADDFVR;SAGLAFSLYQAMAK;SALQSINEWAAQTTDGKLPEVTK 10 34.4 0 75.562 13.9487 12.681 13.5563 11.8738 11.0095 11.6703 11.4829 12.6693 13.1282 10.7653 11.2541 0 P50458 LHX2_HUMAN LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2) LHX2 LH2 Homo sapiens (Human) "axon extension [GO:0048675]; axon guidance [GO:0007411]; cerebral cortex development [GO:0021987]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm development [GO:0007498]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of neurogenesis [GO:0050768]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; telencephalon regionalization [GO:0021978]" chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" VLQVWFQNARAKFR;YYLLAVDKQWHMRCLK 2 7.4 0.84996 -0.075976 0 0 0 0 0 0 0 0 0 5.35639 0 0 P50479 PDLI4_HUMAN PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; excitatory chemical synaptic transmission [GO:0098976]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; recycling endosome lumen [GO:0034777]; recycling endosome membrane [GO:0055038]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903] PHSVTLRGPSPWGFR;VDLGSEVYR 2 7.3 0.96466 -1.2225 0 0 0 0 0 0 0 10.1485 0 0 0 0 P50502 F10A1_HUMAN Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) ST13 AAG2 FAM10A1 HIP SNC6 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983]; protein-macromolecule adaptor activity [GO:0030674] AIDLFTDAIK;AIEINPDSAQPYK;LAILYAK;QDPSVLHTEEMRFLR;VAAIEALNDGELQK 5 16 0 6.9953 10.4992 10.3071 10.2524 9.15365 8.87692 0 0 11.3661 9.11967 11.2773 11.3608 10.3933 P50539 MXI1_HUMAN Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11) MXI1 BHLHC11 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKRGRPR;KSQHQLENLER 2 6.1 0.42718 0.19623 0 0 0 0 0 8.87197 0 10.6538 9.94677 0 0 0 P50542 PEX5_HUMAN Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) PEX5 PXR1 Homo sapiens (Human) "cell development [GO:0048468]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; pexophagy [GO:0000425]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; very long-chain fatty acid metabolic process [GO:0000038]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; peroxisome targeting sequence binding [GO:0000268]; protein carrier chaperone [GO:0140597]; small GTPase binding [GO:0031267] LQAELEEMAK;LQAELEEMAKR 2 1.7 0.87578 -0.12081 0 0 0 0 0 0 10.1313 11.7659 9.65069 0 0 0 P50548 ERF_HUMAN ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) ERF Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]" ALRYYYNK;LEGGGGPAGGFEDEGEDKKVR;QIQLWHFILELLRK 3 7.8 0.95342 -0.77845 0 0 0 9.20019 0 0 9.52148 0 0 0 0 11.0804 P50549 ETV1_HUMAN ETS translocation variant 1 (Ets-related protein 81) ETV1 ER81 Homo sapiens (Human) axon guidance [GO:0007411]; mechanosensory behavior [GO:0007638]; muscle organ development [GO:0007517]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DFAYDSGCMFEK;SLRYYYEK 2 4.4 0.89467 -0.24301 0 0 0 0 0 0 0 0 0 0 6.27988 0 P50549 ETV1_HUMAN ETS translocation variant 1 (Ets-related protein 81) ETV1 ER81 Homo sapiens (Human) axon guidance [GO:0007411]; mechanosensory behavior [GO:0007638]; muscle organ development [GO:0007517]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SLRYYYEK;TLVAFHGLPLKIKK 2 5.3 0.8687 -0.090822 0 3.35811 0 0 0 0 0 0 0 0 0 0 P50552 VASP_HUMAN Vasodilator-stimulated phosphoprotein (VASP) VASP Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289] actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124] QEEASGGPTAPK;VPAQSESVR;VQIYHNPTANSFRVVGRK 3 10.3 0.91676 -0.36454 0 0 0 0 0 10.2273 0 0 0 9.88812 0 0 P50553 ASCL1_HUMAN Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46) ASCL1 ASH1 BHLHA46 HASH1 Homo sapiens (Human) "adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; cellular response to magnetism [GO:0071259]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; heart development [GO:0007507]; lung epithelial cell differentiation [GO:0060487]; lung neuroendocrine cell differentiation [GO:0061100]; motor neuron migration [GO:0097475]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte development [GO:0014003]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell differentiation [GO:0030856]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of timing of subpallium neuron differentiation [GO:0060165]; response to epidermal growth factor [GO:0070849]; response to folic acid [GO:0051593]; response to retinoic acid [GO:0032526]; sensory organ development [GO:0007423]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]" chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LNFSGFGYSLPQQQPAAVAR;LVNLGFATLR 2 12.7 0.88957 -0.2054 0 0 0 0 6.7879 0 7.47135 0 0 6.39003 0 0 P50570 DYN2_HUMAN Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) DNM2 DYN2 Homo sapiens (Human) actin filament bundle organization [GO:0061572]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; protein polymerization [GO:0051258]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]; vesicle scission [GO:0099050] centriole [GO:0005814]; centrosome [GO:0005813]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; synapse [GO:0045202]; uropod [GO:0001931] "enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SH3 domain binding [GO:0017124]" AALAAER;GISPVPINLR;GWLTINNISLMK;HVFAIFNTEQR;IVTTYIR;VTGTNKGISPVPINLR 6 6.1 0.96354 -1.0951 0 0 12.3922 0 0 0 0 0 8.35812 0 0 0 P50579 MAP2_HUMAN Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 MNPEP P67EIF2 Homo sapiens (Human) N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein processing [GO:0016485] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; RNA binding [GO:0003723] EAAEAHRQVR;HLLNVINENFGTLAFCR;SALEDKER 3 7.3 0.97757 -2.1697 12.353 0 0 0 0 0 0 10.5025 0 0 0 0 P50607 TUB_HUMAN Tubby protein homolog TUB Homo sapiens (Human) "intraciliary transport [GO:0042073]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]" cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; intraciliary transport particle A binding [GO:0120160]; protein-containing complex binding [GO:0044877] QELAAVCYETNVLGFKGPRK 1 4 0.85093 -0.079704 0 0 0 5.49486 0 0 0 0 0 0 0 0 P50613 CDK7_HUMAN Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) CDK7 CAK CAK1 CDKN7 MO15 STK1 Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833]" ITATQALK;LGHRSEAK 2 4.6 0.95265 -0.72299 0 0 0 0 0 0 0 0 0 0 0 9.5495 P50747 BPL1_HUMAN Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] HLCS Homo sapiens (Human) biotin metabolic process [GO:0006768]; post-translational protein modification [GO:0043687]; response to biotin [GO:0070781] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363] ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802] DPWTDNCLLLVIATR;EDRLHMDNGLVPQK 2 4 0.94647 -0.65666 0 0 0 0 0 9.72098 0 0 0 0 0 0 P50748 KNTC1_HUMAN Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) KNTC1 KIAA0166 ROD Homo sapiens (Human) cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore involved in kinetochore assembly [GO:1903394]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore microtubule [GO:0005828]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] small GTPase binding [GO:0031267] AHEVAQAK;AQWITYETTQEMLNYAKTRLLK;DECEEMLK;EIAEVNEINLEKVWDMLLEK;LNTEEYLR;MFLSGLS;VIERADEK 7 3.7 0.9745 -3.526 9.83188 0 12.49 0 0 0 0 5.22288 6.87909 0 0 0 P50749 RASF2_HUMAN Ras association domain-containing protein 2 RASSF2 CENP-34 KIAA0168 Homo sapiens (Human) bone remodeling [GO:0046849]; canonical NF-kappaB signal transduction [GO:0007249]; homeostasis of number of cells [GO:0048872]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase activity [GO:0045860]; protein stabilization [GO:0050821]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] protein kinase activity [GO:0004672] GLKPLQEDTPQLMRTR;LEEIAETPATI 2 8.3 0.91869 -0.40297 0 0 0 0 0 0 8.99432 10.841 0 0 0 0 P50851 LRBA_HUMAN Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) LRBA BGL CDC4L LBA Homo sapiens (Human) mitophagy [GO:0000423]; protein localization [GO:0008104]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901] ATDEDILAKGK;DINVSVGSQQPDTK;FDFKPQK;LDMFGNDDK;LFNNSRENRR;LIQVVFGHWDVVTCLAR;LVCAVAVR;NCLECQQHSQLK;SPVDIVTGGISPVRDLDR;VTFEIHK 10 3.9 0.97652 -5.3572 8.18175 0 10.8129 9.69858 0 11.57 12.3161 0 5.74892 0 0 0 P50895 BCAM_HUMAN Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) BCAM LU MSK19 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; transmembrane signaling receptor activity [GO:0004888] AGAAGTAEATAR;GGSGGFGDEC;ITWYRNGQR;SPPYQLDSQGR;VTSALSR 5 7.8 0.97271 -2.668 0 0 0 11.0534 0 0 10.3015 10.6006 0 0 4.83905 0 P50897 PPT1_HUMAN Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) PPT1 CLN1 PPT Homo sapiens (Human) adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; endocytosis [GO:0006897]; fatty-acyl-CoA biosynthetic process [GO:0046949]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; pinocytosis [GO:0006907]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein catabolic process [GO:0030163]; protein depalmitoylation [GO:0002084]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of synapse structure or activity [GO:0050803]; sphingolipid catabolic process [GO:0030149]; visual perception [GO:0007601] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; presynaptic cytosol [GO:0099523]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; sulfatide binding [GO:0120146] LVQAEYWHDPIKEDVYR 1 5.6 0.91893 -0.43575 0 9.23393 0 0 0 0 0 0 0 0 0 0 P50914 RL14_HUMAN Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) RPL14 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALVDGPCTQVR;LVAIVDVIDQNR 2 10.7 0.017308 0.7156 0 0 0 0 0 0 0 0 0 8.57198 8.24322 0 P50990 TCPQ_HUMAN T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) CCT8 C21orf112 CCTQ KIAA0002 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] AHEILPNLVCCSAK;AIADTGANVVVTGGK;ALAENSGVK;ANEVISK;APGFAQMLK;AVDDGVNTFK;DIDEVSSLLR;DWDDDQND;ETEGDVTSVK;ETEGDVTSVKDAK;FAEAFEAIPR;GSTDNLMDDIER;IGLSVSEVIEGYEIACR;KDWDDDQND;LVPGGGATEIELAK;QYGNEVFLAK;TVGATALPR 17 30.7 0 21.264 16.192 13.2896 14.4975 11.2429 11.7678 10.59 12.1575 11.0542 12.4275 13.3853 13.1762 12.2329 P50990 TCPQ_HUMAN T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) CCT8 C21orf112 CCTQ KIAA0002 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] AHEILPNLVCCSAK;AIADTGANVVVTGGK;ALAENSGVK;ANEVISK;AVDDGVNTFK;DIDEVSSLLR;DQMVQHPAAK;DWDDDQND;ETEGDVTSVK;ETEGDVTSVKDAK;FAEAFEAIPR;GSTDNLMDDIER;IGLSVSEVIEGYEIACR;KDWDDDQND;LVPGGGATEIELAK;QYGNEVFLAK;TVGATALPR 17 35.6 0.89288 -0.22262 0 0 0 0 0 8.91982 0 0 0 0 0 0 P50991 TCPD_HUMAN T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) CCT4 CCTD SRB Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666] cell body [GO:0044297]; cell projection [GO:0042995]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] AFADAMEVIPSTLAENAGLNPISTVTELR;ALIAGGGAPEIELALR;AVADAIR;AYILNLVK;FSNISAAK;GMDKMIQDGK;IDDVVNTR;MLVELSK;SIHDALCVIRCLVK;SIHDALCVIRCLVKK;VIDPATATSVDLRDIK;VSNSGITR 12 24.5 0 18.222 10.0887 9.47324 10.8097 9.32921 0 10.8241 9.07452 12.759 9.81072 9.34871 11.9996 12.2639 P50993 AT1A2_HUMAN Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) ATP1A2 KIAA0778 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; L-ascorbic acid metabolic process [GO:0019852]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neuronal action potential propagation [GO:0019227]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; response to potassium ion [GO:0035864]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542]" caveola [GO:0005901]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239] AAVPDAVGK;AAVPDAVGKCR;EKELDELKK;EYSPAATTAENGGGKK;GVGIISEGNETVEDIAAR;IISSHGCK;ILDRCSTILVQGK;NSVFQQGMK;QGAIVAVTGDGVNDSPALK;TGTLTQNR;VIMVTGDHPITAK;VTWWFCAFPYSLLIFIYDEVR 12 14.2 0.97797 -1.9505 0 0 0 0 9.01408 8.70356 9.65782 0 0 0 6.98732 0 P50995 ANX11_HUMAN Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) ANXA11 ANX11 Homo sapiens (Human) cytokinetic process [GO:0032506]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592] azurophil granule [GO:0042582]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; spindle [GO:0005819]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548] DAQELYAAGENR;SETDLLDIR;SETDLLDIRSEYKR;TLEEAIR 4 6.5 0.95497 -0.97359 0 9.82942 0 0 0 0 0 12.3372 0 0 8.36584 0 P51003 PAPOA_HUMAN Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) PAPOLA PAP Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; cytosolic mRNA polyadenylation [GO:0180011]; mRNA 3'-end processing [GO:0031124]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] IAAMHVKR;NLDIRCIR;SDFFTSFYDKLK;TSSPHKEESPKK 4 5.4 0.97943 -1.8528 0 11.3424 9.9935 0 0 0 0 0 0 0 0 7.37121 P51114 FXR1_HUMAN RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) FXR1 Homo sapiens (Human) "animal organ development [GO:0048513]; apoptotic process [GO:0006915]; dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; mRNA transport [GO:0051028]; muscle organ development [GO:0007517]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mRNA catabolic process [GO:1902373]; negative regulation of translation [GO:0017148]; negative regulation of tumor necrosis factor production [GO:0032720]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of translation [GO:0045727]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]; skeletal muscle organ development [GO:0060538]; spermatid development [GO:0007286]" axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; ribosome [GO:0005840] molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA strand annealing activity [GO:0033592]; translation regulator activity [GO:0045182] CTVDVPEDLR;EENTQEAAVLNGVS;EVEQLRMER;LQRTPGEEK;QVPFNEVR;VIQEIVDK 6 9.3 0.97476 -3.4673 0 0 0 0 0 0 0 0 11.0745 4.3194 0 0 P51116 FXR2_HUMAN RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) FXR2 FMR1L2 Homo sapiens (Human) "animal organ development [GO:0048513]; dentate gyrus development [GO:0021542]; mRNA destabilization [GO:0061157]; mRNA transport [GO:0051028]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of translation [GO:0045727]; regulation of mRNA stability [GO:0043488]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] EEPNRAGPGDR;GPPPAPRPTSR;QLAAAFQEEFTVR;VIQEIVDK 4 6.4 0.98092 -1.7466 0 0 0 0 0 0 0 11.7373 0 0 0 0 P51148 RAB5C_HUMAN Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) RAB5C RABL Homo sapiens (Human) endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227] azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] LVLLGESAVGK;NEPQNATGAPGR;QASPNIVIALAGNK 3 17.1 0.0047619 1.483 0 0 0 0 0 0 0 0 0 10.0979 9.54032 0 P51149 RAB7A_HUMAN Ras-related protein Rab-7a (EC 3.6.5.2) RAB7A RAB7 Homo sapiens (Human) "autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; intracellular transport [GO:0046907]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle recycling via endosome [GO:0036466]; viral release from host cell [GO:0019076]" alveolar lamellar body [GO:0097208]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; small GTPase binding [GO:0031267] ASAESCSC;ATIGADFLTK;DPENFPFVVLGNK;EAINVEQAFQTIAR;NNIPYFETSAK;VIILGDSGVGK 6 32.4 0 40.477 12.7162 13.3796 12.4004 4.59908 9.56596 10.9115 12.3796 0 10.7721 11.5246 10.7845 10.8665 P51157 RAB28_HUMAN Ras-related protein Rab-28 RAB28 Homo sapiens (Human) intracellular protein transport [GO:0006886] ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] LNKAEIEQSQGHFIIFISSTNRE 1 11.3 0.58927 0.17852 0 0 0 0 8.17238 0 0 0 0 0 0 10.3864 P51160 PDE6C_HUMAN "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)" PDE6C PDEA2 Homo sapiens (Human) "cAMP-mediated signaling [GO:0019933]; phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; visual perception [GO:0007601]" plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" EVNFYKIIDYILHGKEEIK;LHGSSILER;LNVDVIDDCEEK;LQVGFIDFVCTFVYKEFSR;QTGYVTK;TPDGREVNFYK 6 8.3 0.95227 -0.77172 0 0 6.7811 0 0 10.8582 0 9.56449 7.37495 9.98996 9.17218 0 P51168 SCNNB_HUMAN Epithelial sodium channel subunit beta (Beta-ENaC) (ENaC subunit beta) (ENaCB) (Epithelial Na(+) channel subunit beta) (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) SCNN1B Homo sapiens (Human) aldosterone metabolic process [GO:0032341]; artery smooth muscle contraction [GO:0014824]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; epithelial fluid transport [GO:0042045]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; intracellular sodium ion homeostasis [GO:0006883]; leukocyte activation involved in inflammatory response [GO:0002269]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; potassium ion homeostasis [GO:0055075]; regulation of blood pressure [GO:0008217]; renal system process [GO:0003014]; response to food [GO:0032094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699] SCFQDHMIR 1 1.4 0.84773 -0.067505 0 0 0 0 0 0 6.59896 0 0 0 0 0 P51170 SCNNG_HUMAN Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium channel epithelial 1 subunit gamma) SCNN1G Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium channel activity [GO:0005272]; WW domain binding [GO:0050699] AFSNQLTDTQMLDEL 1 2.3 0.78391 0.030995 0 0 0 0 0 0 0 0 0 0 9.78157 0 P51172 SCNND_HUMAN Epithelial sodium channel subunit delta (Delta-ENaC) (ENaCD) (Epithelial Na(+) channel subunit delta) (Amiloride-sensitive sodium channel subunit delta) (Delta-NaCH) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED) SCNN1D DNACH Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; sodium channel activity [GO:0005272] LSHSGSR 1 0.9 0.91066 -0.31866 0 0 0 0 0 0 0 7.63829 0 0 0 0 P51178 PLCD1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)" PLCD1 Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; GTPase activating protein binding [GO:0032794]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" EDKLRLAQELSDMVIYCK;ELQNFLKELNIQVDDSYAR;MQCLGIR;QKLQHWIHSCLR;VISGQQLPK 5 8.4 0.98008 -2.0417 0 0 0 0 0 9.97585 8.67094 0 0 15.6868 9.78247 0 P51398 RT29_HUMAN "Small ribosomal subunit protein mS29 (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein)" DAP3 MRPS29 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DLLQSSYNK;FLNQIKVQEKYVWNK;VQEKYVWNK 3 6 0.97389 -1.4074 0 11.4253 0 9.61003 0 0 0 0 4.26266 0 0 0 P51449 RORG_HUMAN Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) RORC NR1F3 RORG RZRG Homo sapiens (Human) adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; xenobiotic metabolic process [GO:0006805] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; ligand-activated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" AYNADNRTVFFEGK;NRCQHCRLQK;RTQIEVIPCK 3 6.8 0.97295 -2.5043 12.1611 0 0 0 0 0 0 0 0 0 6.91229 0 P51451 BLK_HUMAN Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) BLK Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein binding [GO:0032092] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] HFVVALYDYTAMNDRDLQMLK;SQGRKEAER;VESLEMERWFFRSQGR 3 8.3 0.96714 -1.3077 0 12.9004 0 0 7.67871 0 0 0 0 0 0 0 P51508 ZNF81_HUMAN Zinc finger protein 81 (HFZ20) ZNF81 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEKLYICTKCGK;DSFGKSFKHNLDLHIHNK;THTREKPYK 3 5.9 0.98056 -1.7255 0 0 0 0 0 10.7537 0 0 0 8.08603 0 0 P51511 MMP15_HUMAN Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2) MMP15 Homo sapiens (Human) collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to estradiol [GO:0032355] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EWMKRPRCGVPDQFGVR;QDGRFVFFKGDR;VLLYCKR;VLLYCKRSLQEWV 4 6.3 0.97456 -3.6746 0 0 0 0 0 0 0 0 0 0 0 8.68429 P51512 MMP16_HUMAN Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) MMP16 C8orf57 MMPX2 Homo sapiens (Human) chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] QTEKHKTYEELSSITY;YALTGQK 2 5 0.84964 -0.076074 0 6.92647 0 7.96006 7.89263 8.13366 0 0 0 0 7.39592 0 P51513 NOVA1_HUMAN RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1) NOVA1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] IQISKKGEFVPGTR 1 2.8 0.97596 -1.4767 0 0 0 0 0 0 0 0 8.42869 0 0 0 P51523 ZNF84_HUMAN Zinc finger protein 84 (Zinc finger protein HPF2) ZNF84 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LYECSECRKR;SQLNTHQR 2 2.4 0.94385 -0.62761 0 0 0 0 0 0 11.8599 0 0 0 0 0 P51530 DNA2_HUMAN DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] DNA2 DNA2L KIAA0083 Homo sapiens (Human) "base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; nucleic acid metabolic process [GO:0090304]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]" HLKEMYRLNLSQDEIK;IINDLLAR;IVCDGQYLHNFQCK;LGQIQKVHPAIQQFTEQEICRSK;LIIDLPSREHESLCHILGDFQRE;QEVEDYLPSFCK;TGQMYPVPANHLDK;TGQMYPVPANHLDKRELLK;TQLASLPQIIEEEK;VANAVINLRHFKDVK 10 13.6 0.97399 -3.0347 0 6.6499 8.25668 5.93126 0 6.91624 4.49499 0 0 0 10.9784 10.5722 P51530 DNA2_HUMAN DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] DNA2 DNA2L KIAA0083 Homo sapiens (Human) "base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; nucleic acid metabolic process [GO:0090304]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]" HLKEMYRLNLSQDEIK;IINDLLAR;IVCDGQYLHNFQCK;LIIDLPSREHESLCHILGDFQRE;QEVEDYLPSFCK;TGQMYPVPANHLDK;TGQMYPVPANHLDKRELLK;TQLASLPQIIEEEK;TTTICTLVPAPEQVEK 9 14.8 0.87916 -0.14137 0 0 0 0 10.9471 0 0 0 0 0 0 0 P51531 SMCA2_HUMAN Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) SMARCA2 BAF190B BRM SNF2A SNF2L2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; nucleosome array spacer activity [GO:0140750]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]" DPAKEDVEKAK;DVDYSDALTEKQWLR;EEESEDESNEEEEEEDEEESESEAK;EQSEGSGTDDE;IAHRIQELENLPGSLPPDLR;ILYRHMQAK;ISYKGTPAMR;KGKGGAK;QEVVACMR;QLSEVFIQLPSRK;SDSEESDSDYEEEDEEEESSR;TLMNTIMQLR 12 10.1 0.97296 -2.924 4.7855 0 0 5.83905 0 10.4597 10.627 0 10.6728 6.08155 6.19056 10.1003 P51532 SMCA4_HUMAN Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) SMARCA4 BAF190A BRG1 SNF2B SNF2L4 Homo sapiens (Human) chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; chromatin [GO:0000785]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; nuclear androgen receptor binding [GO:0050681]; nucleosome array spacer activity [GO:0140750]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]" EEARNPKR;ILTGTDAPK;LDGTTKAEDR;QLSEVFIQLPSRK;SGSGSEED;TLMNTIMQLR;VLYRHMQAK;YLRLDGTTKAEDR 8 4.3 0.97472 -3.9119 0 12.2783 8.32112 0 0 8.50076 6.64357 0 7.56362 7.62132 0 0 P51553 IDH3G_HUMAN "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)" IDH3G Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] isocitrate dehydrogenase complex (NAD+) [GO:0045242]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] ATP binding [GO:0005524]; isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] IAEYAFK;LAQESGRK 2 3.8 0.95573 -0.84269 0 0 0 0 0 0 0 9.43661 0 0 9.46822 0 P51571 SSRD_HUMAN Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) SSR4 TRAPD Homo sapiens (Human) endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Sec61 translocon complex [GO:0005784] FFDEESYSLLR;NNEDISIIPPLFTVSVDHR 2 17.3 0.93706 -0.56143 0 0 0 0 0 0 7.77182 0 0 0 0 0 P51572 BAP31_HUMAN B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) BCAP31 BAP31 DXS1357E Homo sapiens (Human) "apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein targeting to mitochondrion [GO:0006626]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]" clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288]; protein-containing complex binding [GO:0044877] AENQVLAMR 1 2.9 0.93192 -0.4909 0 0 0 0 0 0 0 0 0 0 0 11.375 P51575 P2RX1_HUMAN P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor) P2RX1 P2X1 Homo sapiens (Human) "apoptotic process [GO:0006915]; calcium ion transmembrane transport [GO:0070588]; ceramide biosynthetic process [GO:0046513]; insemination [GO:0007320]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; platelet activation [GO:0030168]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of blood pressure [GO:0008217]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of vascular associated smooth muscle contraction [GO:0003056]; response to ATP [GO:0033198]; serotonin secretion by platelet [GO:0002554]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]" external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; monoatomic cation channel activity [GO:0005261]; protein-containing complex binding [GO:0044877]; purinergic nucleotide receptor activity [GO:0001614]; suramin binding [GO:0043924] CVAFNDTVK 1 2.3 0.91741 -0.40747 0 11.0955 0 0 0 0 0 0 0 0 0 0 P51580 TPMT_HUMAN Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Homo sapiens (Human) methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829] S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119] CLEKVDAFEERHK 1 5.3 0.97765 -1.5208 0 0 0 0 8.96538 0 0 0 0 0 0 0 P51587 BRCA2_HUMAN Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) BRCA2 FACD FANCD1 Homo sapiens (Human) "brain development [GO:0007420]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; centrosome duplication [GO:0051298]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; female gonad development [GO:0008585]; hematopoietic stem cell proliferation [GO:0071425]; inner cell mass cell proliferation [GO:0001833]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male meiosis I [GO:0007141]; mitotic recombination-dependent replication fork processing [GO:1990426]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; oocyte maturation [GO:0001556]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of cytokinesis [GO:0032465]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA-templated transcription [GO:0006355]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]" "BRCA2-MAGE-D1 complex [GO:0033593]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; lateral element [GO:0000800]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]" gamma-tubulin binding [GO:0043015]; histone H3 acetyltransferase activity [GO:0010484]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697] AQLDPPLLAVLKNGR;DLLDTENKRK;EAAKYVEAQQKR;EIDDQKNCKK;FWIDLNEDIIKPHMLIAASNLQWRPESK;IPEKNNDYMNK;IVCVSHETIK;NKNAAIK;NPEHCVNSEMEK;SDISLNIDK;VIKENNENK;VQFNQNTNLR;YDTEIDR 13 4.4 0.97811 -7.1647 0 9.74164 11.3354 9.49949 8.4113 9.95871 0 10.2782 11.1347 12.0317 9.02289 0 P51606 RENBP_HUMAN N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) RENBP Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; regulation of blood pressure [GO:0008217] cytosol [GO:0005829]; extracellular exosome [GO:0070062] endopeptidase inhibitor activity [GO:0004866]; identical protein binding [GO:0042802]; N-acylglucosamine 2-epimerase activity [GO:0050121]; peptidase inhibitor activity [GO:0030414] GLPARQDMEKER;VGQELDR;VYDDLKYVWLQGR;YVWLQGRQVWMYCR 4 9.1 0.95054 -0.6674 8.5763 0 0 7.47897 7.51838 0 0 11.0284 0 9.19098 0 10.3297 P51608 MECP2_HUMAN Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) MECP2 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; behavioral fear response [GO:0001662]; biogenic amine metabolic process [GO:0006576]; cardiolipin metabolic process [GO:0032048]; catecholamine secretion [GO:0050432]; cellular response to isoquinoline alkaloid [GO:0071317]; cellular response to potassium ion [GO:0035865]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; gene expression [GO:0010467]; genomic imprinting [GO:0071514]; glial cell proliferation [GO:0014009]; glucocorticoid metabolic process [GO:0008211]; glutamine metabolic process [GO:0006541]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; inositol metabolic process [GO:0006020]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; lung alveolus development [GO:0048286]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of dendrite extension [GO:1903860]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of respiratory gaseous exchange [GO:1903941]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuron maturation [GO:0042551]; Notch signaling pathway [GO:0007219]; olfactory bulb development [GO:0021772]; oligodendrocyte development [GO:0014003]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of retrograde dense core granule transport [GO:1901956]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; proprioception [GO:0019230]; protein localization [GO:0008104]; regulation of action potential firing threshold [GO:0099611]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of synapse organization [GO:0050807]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to alcohol [GO:0097305]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to other organism [GO:0051707]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; startle response [GO:0001964]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; thalamus development [GO:0021794]; trans-synaptic signaling by BDNF [GO:0099191]; ventricular cardiac muscle tissue development [GO:0003229]; ventricular system development [GO:0021591]; visual learning [GO:0008542] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; four-way junction DNA binding [GO:0000400]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322] APGTGRGR;EEPVDSRTPVTER;KPGSVVAAAAAEAKKK;SAGKYDVYLINPQGK 4 10.7 0.96687 -1.292 0 0 0 8.20271 0 0 0 6.0093 0 6.47583 0 5.45733 P51610 HCFC1_HUMAN Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] HCFC1 HCF1 HFC1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein-containing complex assembly [GO:0043254]; release from viral latency [GO:0019046] cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; neuronal cell body [GO:0043025]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Set1C/COMPASS complex [GO:0048188] cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713] LSSPSIK;SPAFVQLAPLSSKVR 2 1.1 0.91311 -0.38415 0 0 0 0 0 6.51597 0 0 0 0 0 0 P51648 AL3A2_HUMAN Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase) ALDH3A2 ALDH10 FALDH Homo sapiens (Human) aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]; sesquiterpenoid metabolic process [GO:0006714] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; long-chain-alcohol oxidase activity [GO:0046577]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814]; protein homodimerization activity [GO:0042803] ALLIFLVVHRLR 1 2.4 0.30481 0.24953 0 0 0 0 0 0 6.08649 6.04264 9.43717 0 5.87344 0 P51649 SSDH_HUMAN "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" ALDH5A1 SSADH Homo sapiens (Human) "central nervous system development [GO:0007417]; gamma-aminobutyric acid catabolic process [GO:0009450]; glutamate metabolic process [GO:0006536]; post-embryonic development [GO:0009791]; succinate metabolic process [GO:0006105]; synaptic transmission, GABAergic [GO:0051932]" mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] identical protein binding [GO:0042802]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777] VEKQVNDAVSKGATVVTGGK 1 3.7 0.84997 -0.076209 0 0 0 0 0 0 0 9.60973 0 0 0 0 P51665 PSMD7_HUMAN 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40) PSMD7 MOV34L Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774] protein homodimerization activity [GO:0042803] VVVHPLVLLSVVDHFNRIGK 1 6.2 0.81697 -0.01737 0 0 0 0 0 0 0 9.33 0 0 0 0 P51671 CCL11_HUMAN Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11) CCL11 SCYA11 Homo sapiens (Human) actin filament organization [GO:0007015]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; chronic inflammatory response [GO:0002544]; cytoskeleton organization [GO:0007010]; eosinophil chemotaxis [GO:0048245]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; mammary duct terminal end bud growth [GO:0060763]; mast cell chemotaxis [GO:0002551]; negative regulation of neurogenesis [GO:0050768]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of GTPase activity [GO:0043547]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; response to interleukin-13 [GO:0035962]; response to interleukin-4 [GO:0070670]; response to radiation [GO:0009314]; response to virus [GO:0009615]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR3 chemokine receptor binding [GO:0031728]; chemokine activity [GO:0008009]; protein dimerization activity [GO:0046983]; receptor ligand activity [GO:0048018] KWVQDSMKYLDQK 1 13.4 0.97552 -1.4711 0 0 0 0 0 0 0 0 0 0 9.40559 0 P51674 GPM6A_HUMAN Neuronal membrane glycoprotein M6-a (M6a) GPM6A M6A Homo sapiens (Human) neural retina development [GO:0003407]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; positive regulation of filopodium assembly [GO:0051491]; regulation of synapse organization [GO:0050807]; response to bacterium [GO:0009617]; stem cell differentiation [GO:0048863]; synapse assembly [GO:0007416] axonal growth cone [GO:0044295]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] calcium channel activity [GO:0005262] TAGDTLDVFTMIDIFK 1 5.8 0.7834 0.026296 0 0 7.40735 0 0 0 0 0 0 0 0 0 P51677 CCR3_HUMAN C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193) CCR3 CMKBR3 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell proliferation [GO:0001938] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] MLLRAHKPGSSRR;MTIFCLVLPLLVMAICYTGIIKTLLRCPSK 2 11.4 0.37909 0.22009 5.67993 0 0 0 0 0 0 0 0 0 8.75722 0 P51681 CCR5_HUMAN C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) CCR5 CMKBR5 Homo sapiens (Human) apoptotic process [GO:0006915]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of macrophage apoptotic process [GO:2000110]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; signaling [GO:0023052] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; virus receptor activity [GO:0001618] IVILGLVLPLLVMVICYSGILK;IVILGLVLPLLVMVICYSGILKTLLR;TLLRCRNEK 3 8.8 0.95512 -0.93702 0 0 0 0 0 0 9.55528 0 0 0 0 9.0798 P51684 CCR6_HUMAN C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196) CCR6 CKRL3 CMKBR6 GPR29 STRL22 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; DN2 thymocyte differentiation [GO:1904155]; DN3 thymocyte differentiation [GO:1904156]; humoral immune response [GO:0006959]; immune response [GO:0006955]; isotype switching to IgA isotypes [GO:0048290]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration [GO:0072676]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; regulation of T cell migration [GO:2000404]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; sperm principal piece [GO:0097228] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023] QTSETADNDNASSFTM 1 4.3 0.7835 0.022749 0 2.53391 0 0 0 3.5302 0 0 0 0 0 0 P51686 CCR9_HUMAN C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199) CCR9 GPR28 Homo sapiens (Human) "calcium-mediated signaling [GO:0019722]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] TLKNLGCISQAQWVSFTRR 1 5.1 0.76414 0.067445 0 0 0 0 0 0 0 0 11.0895 0 0 0 P51687 SUOX_HUMAN "Sulfite oxidase, mitochondrial (EC 1.8.3.1)" SUOX Homo sapiens (Human) sulfur compound metabolic process [GO:0006790] mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; sulfite oxidase activity [GO:0008482] ELNIVCK 1 1.3 0.91047 -0.31922 0 0 0 0 0 0 0 0 0 0 6.60961 0 P51688 SPHM_HUMAN N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase) SGSH HSS Homo sapiens (Human) determination of adult lifespan [GO:0008340]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; motor behavior [GO:0061744] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] metal ion binding [GO:0046872]; N-sulfoglucosamine sulfohydrolase activity [GO:0016250]; sulfuric ester hydrolase activity [GO:0008484] ADLAAQYTTVGR;LVHNLNFK;SLPLLLSQAGVR;TIHLTGR 4 7.8 0.95539 -0.85442 9.3786 9.8627 0 0 0 0 8.60814 0 0 0 9.15639 0 P51689 ARSD_HUMAN Arylsulfatase D (ASD) (EC 3.1.6.-) ARSD Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] CLPSMAFK 1 2.1 0.91376 -0.39033 0 11.0719 0 0 0 0 0 0 0 0 0 0 P51693 APLP1_HUMAN Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30] APLP1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to norepinephrine stimulus [GO:0071874]; central nervous system development [GO:0007417]; cytosolic mRNA polyadenylation [GO:0180011]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; nervous system development [GO:0007399]; regulation of translation [GO:0006417] basement membrane [GO:0005604]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] alpha-2A adrenergic receptor binding [GO:0031694]; alpha-2B adrenergic receptor binding [GO:0031695]; alpha-2C adrenergic receptor binding [GO:0031696]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914] EQRHTLR 1 1.1 0.98042 -1.6387 0 0 0 0 0 0 0 0 0 0 8.72506 0 P51784 UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) USP11 UHX1 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; transcription corepressor binding [GO:0001222] AAYVLFYQRQDVAR;FLVEPQEDTR;LFGGLCFR;QLFTLQTVNSNGTSDR 4 5 0.97512 -1.3832 0 0 0 0 10.5574 0 0 10.1973 0 0 0 11.3436 P51790 CLCN3_HUMAN H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) CLCN3 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; chloride transmembrane transport [GO:1902476]; endosomal lumen acidification [GO:0048388]; negative regulation of cell volume [GO:0045794]; phagocytosis, engulfment [GO:0006911]; photoreceptor cell maintenance [GO:0045494]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of pH [GO:0006885]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]" axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; ruffle membrane [GO:0032587]; secretory granule [GO:0030141]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle membrane [GO:0012506] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; PDZ domain binding [GO:0030165]; voltage-gated chloride channel activity [GO:0005247]; volume-sensitive chloride channel activity [GO:0072320] EGIYEAHIR;ESQRLVGFALRR 2 2.6 0.94446 -0.63585 0 6.47049 0 0 0 0 0 8.61651 0 0 0 0 P51793 CLCN4_HUMAN H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4) CLCN4 Homo sapiens (Human) chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; non-motile cilium assembly [GO:1905515] ciliary base [GO:0097546]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247] DSERLIGFAQR;IVVTIFTFGMK;SFFAALVAAFTLR 3 4.6 0.97567 -2.3148 0 0 0 7.60518 10.2764 0 0 0 0 8.54373 0 0 P51795 CLCN5_HUMAN H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5) CLCN5 CLCK2 Homo sapiens (Human) chloride transport [GO:0006821]; endocytosis [GO:0006897]; monoatomic ion transmembrane transport [GO:0034220]; renal system process [GO:0003014] apical part of cell [GO:0045177]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; voltage-gated chloride channel activity [GO:0005247] GGELPDRPAGVGVYSAMWQLALTLILK;SFFAALVAAFTLR 2 4.9 0.71339 0.14489 0 0 0 0 0 0 0 0 0 6.239 0 0 P51797 CLCN6_HUMAN H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6) CLCN6 KIAA0046 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; response to mechanical stimulus [GO:0009612]; signal transduction [GO:0007165] endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247] CCLCTQASHQK;GSLCCCCRWCCCCGER;KIQFNFPYFR;MAGCRGSLCCCCRWCCCCGER;WCCCCGERETR 5 4.7 0.9154 -0.36694 0 0 5.13918 0 10.0831 0 0 6.72724 0 8.67909 6.21358 0 P51798 CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) CLCN7 Homo sapiens (Human) transepithelial chloride transport [GO:0030321] chloride channel complex [GO:0034707]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247] IPHVVRLKTLVIK;LKTLVIKVSGVILSVVGGLAVGK 2 3.6 0.35644 0.23361 0 0 3.74964 5.25444 0 3.01676 5.25629 0 0 4.70233 4.93234 0 P51800 CLCKA_HUMAN Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1) CLCNKA Homo sapiens (Human) chloride transport [GO:0006821]; renal absorption [GO:0070293]; transepithelial chloride transport [GO:0030321] basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247] DTPLEEVVK;TMLAGVILEDYLDIK;VGPFVHLSVMIAAYLGRVR 3 6.3 0.95826 -1.0136 0 0 11.8678 0 0 0 10.7401 0 0 0 0 0 P51805 PLXA3_HUMAN Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) PLXNA3 PLXN4 SEX Homo sapiens (Human) axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; trigeminal nerve structural organization [GO:0021637] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] ALTLPAMMGLAAGGGLLLLAITAVLVAYKR;AQGEHPDEFGFLLDHVQTARSLNR;CWAQRPSCGLCLKADPR;FNCGWCISEHRCQLR;GKNLIPAAAGSSR;GPASGGTR;LAPNLTELR;TESVAEK;THCPAPK;VAGVRCNSIPAEYISAER 10 7.9 0.97485 -3.7348 10.6792 7.52709 9.75566 8.11603 8.51471 0 11.9423 0 0 4.15299 11.3213 11.2177 P51810 GP143_HUMAN G-protein coupled receptor 143 (Ocular albinism type 1 protein) GPR143 OA1 Homo sapiens (Human) eye pigment biosynthetic process [GO:0006726]; G protein-coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886] dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; L-tyrosine binding [GO:0072545] LGTFCCPTR 1 2.2 0.84684 -0.067863 0 0 0 0 0 6.44852 0 0 0 0 0 0 P51813 BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) BMX Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; phosphatidylinositol biosynthetic process [GO:0006661]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] EYPIYIVTEYISNGCLLNYLR;LKSSSSSEDVASSNQK;SQSEQLLRQK;VLKIPRAVPVLK;WSAPEVFHYFK 5 10.4 0.96363 -1.095 0 0 4.51437 0 0 8.7807 9.44429 8.72928 0 12.5167 0 7.74039 P51816 AFF2_HUMAN AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19) AFF2 FMR2 OX19 Homo sapiens (Human) brain development [GO:0007420]; learning or memory [GO:0007611]; mRNA processing [GO:0006397]; negative regulation of gene expression [GO:0010629]; nuclear speck organization [GO:0035063]; regulation of gene expression [GO:0010468]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] nuclear speck [GO:0016607] G-quadruplex RNA binding [GO:0002151] ERPLLSLIREK;GYEHWDMADK;NEPSFFPEQK 3 2.4 0.98068 -1.6168 0 0 0 0 0 8.77854 0 0 7.93091 0 4.54189 0 P51826 AFF3_HUMAN AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) AFF3 LAF4 Homo sapiens (Human) embryonic hindlimb morphogenesis [GO:0035116]; regulation of gene expression [GO:0010468]; response to tumor necrosis factor [GO:0034612] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; super elongation complex [GO:0032783] DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690] CDNEDDYR;GVPASKPEPAR;LVFDDMPRSADYFMQEAK;YSKALIDYFK 4 3.8 0.97804 -2.1439 3.4167 0 0 0 0 9.98485 0 0 6.56487 0 0 0 P51828 ADCY7_HUMAN Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) ADCY7 KIAA0037 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to ethanol [GO:0071361]; cellular response to lithium ion [GO:0071285]; intracellular signal transduction [GO:0035556]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; regulation of adaptive immune response [GO:0002819] membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] FDQIAKANECMRIK 1 1.3 0.86569 -0.088319 0 0 0 7.81526 9.04699 0 0 0 0 7.81826 0 0 P51841 GUC2F_HUMAN "Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)" GUCY2F GUC2F RETGC2 Homo sapiens (Human) cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; detection of light stimulus involved in visual perception [GO:0050908]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601] nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] ALPEVAARLAIER;FSLGDFGDLKSIK;LDWMFKSSLLLDLIK;TEKLLTQMLPPSVAESLKK 4 5.4 0.98061 -2.0348 0 0 10.7689 9.1068 0 0 0 11.081 0 0 9.01608 9.68811 P51843 NR0B1_HUMAN Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1) NR0B1 AHC DAX1 Homo sapiens (Human) adrenal gland development [GO:0030325]; endodermal cell differentiation [GO:0035987]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; protein localization [GO:0008104]; response to immobilization stress [GO:0035902]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283] centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] ENDCNHH;QGSILYSMLTSAKQTYAAPK 2 6.8 0.93223 -0.49368 0 0 6.04054 6.04413 0 0 0 0 0 0 0 0 P51854 TKTL1_HUMAN Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein) TKTL1 TKR TKT2 Homo sapiens (Human) glucose catabolic process [GO:0006007]; thiamine metabolic process [GO:0006772] cytosol [GO:0005829] metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] ADAIIKLIESQIQTSR;GVSMLQDSWSSVISYQKVLRHCVSDK;LGYANNR;QDIFIRVIDLFTIKPLDVATIVSSAK 4 13.5 0.95562 -0.85614 0 9.06313 0 10.8745 9.07668 9.44853 11.6202 0 11.5826 0 0 9.026 P51857 AK1D1_HUMAN Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) AKR1D1 SRD5B1 Homo sapiens (Human) androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; bile acid catabolic process [GO:0030573]; C21-steroid hormone metabolic process [GO:0008207]; cholesterol catabolic process [GO:0006707]; digestion [GO:0007586] cytosol [GO:0005829] aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; Delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; ketosteroid monooxygenase activity [GO:0047086]; steroid binding [GO:0005496]; steroid dehydrogenase activity [GO:0016229] GVVVIPK;REDIFYCGK;SLGVSNFNR;SLGVSNFNRR 4 8 0.97962 -1.5371 0 0 12.3842 0 0 0 11.9899 11.6903 0 0 11.6215 9.17986 P51858 HDGF_HUMAN Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) HDGF HMG1L2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "actin binding [GO:0003779]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin binding [GO:0015631]" EAENPEGEEK;EKFGKPNKR;IDEMPEAAVK;LVIDEPAK 4 15.4 0.0087336 1.0706 0 0 0 0 0 0 10.6447 0 10.8728 11.5668 8.99206 0 P51861 CDR1_HUMAN Cerebellar degeneration-related antigen 1 (CDR34) CDR1 Homo sapiens (Human) RGFSGRLGGYWK;TLIDWKTWISFWKTLIDWK;TWISFWKTLIDWKI 3 12.2 0.78044 0.033571 7.64407 7.01391 0 0 0 0 0 0 0 10.9209 0 0 P51878 CASP5_HUMAN Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10] CASP5 ICH3 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; positive regulation of inflammatory response [GO:0050729]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] STSVKKDNHK;TRGSIFITELITCFQK;VEGVFIFLIEDSGKK;VEGVFIFLIEDSGKKK 4 9.4 0.97736 -1.5222 0 0 12.2488 8.94682 0 5.4923 11.1021 0 4.15299 0 0 0 P51884 LUM_HUMAN Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican) LUM LDC SLRR2D Homo sapiens (Human) collagen fibril organization [GO:0030199]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; visual perception [GO:0007601] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021] NNQIDHIDEK;SLEDLQLTHNKITK 2 7.1 0.95892 -1.0365 0 0 0 0 0 0 0 0 0 8.64454 8.20359 0 P51888 PRELP_HUMAN Prolargin (Proline-arginine-rich end leucine-rich repeat protein) PRELP SLRR2A Homo sapiens (Human) cellular senescence [GO:0090398]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201] IETIPNGYFK 1 2.6 0.93651 -0.51828 0 0 0 0 0 9.4028 0 0 0 0 0 0 P51911 CNN1_HUMAN "Calponin-1 (Basic calponin) (Calponin H1, smooth muscle)" CNN1 Homo sapiens (Human) actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of smooth muscle contraction [GO:0006940] actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516] EQELREWIEGVTGRR;MLAQKYDHQR 2 9 0.98061 -1.6476 0 0 8.58267 0 0 0 0 0 0 0 8.3647 0 P51946 CCNH_HUMAN Cyclin-H (MO15-associated protein) (p34) (p37) CCNH Homo sapiens (Human) protein stabilization [GO:0050821]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367] CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] GYEDDDYVSK;IIMLTCAFLACK 2 6.8 0.89783 -0.23261 0 0 0 0 0 0 0 0 9.16443 0 0 3.73162 P51957 NEK4_HUMAN Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772] ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DMNSLVYRIIEGK;ELPSAIMPGSEK;HILHRDLK;LDSKESCEDVPVANPVSEFK;PLAAYCYLRVVGKGSYGEVTLVK;RAAEQEAQLLSQLKHPNIVTYK;TNIIKVGDLGIAR;VAEEAEEIHFK 8 14.5 0.56147 0.18276 0 0 0 0 0 0 0 0 10.0136 0 0 0 P51957 NEK4_HUMAN Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772] ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DMNSLVYRIIEGK;ELPSAIMPGSEK;HILHRDLK;LDSKESCEDVPVANPVSEFK;PLAAYCYLRVVGKGSYGEVTLVK;RDGKQYLHEK;TNIIKVGDLGIAR;VAEEAEEIHFK 8 14.6 0.97692 -5.6778 8.86022 10.4014 0 5.50634 13.3681 11.7724 0 7.64068 0 0 0 6.51583 P51965 UB2E1_HUMAN Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) UBE2E1 UBCH6 Homo sapiens (Human) ISG15-protein conjugation [GO:0032020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] ELADITLDPPPNCSAGPK;EVGRPREVR;KEVGRPR 3 17.5 0.96386 -1.1896 0 0 0 0 9.51471 0 10.1319 0 0 0 0 0 P51970 NDUA8_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) NDUFA8 Homo sapiens (Human) "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877] HCRKQQAK 1 4.7 0.8707 -0.095167 0 0 0 9.16274 0 0 0 0 0 0 0 0 P51991 ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) HNRNPA3 HNRPA3 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] EDSVKPGAHLTVK;EPEQLRK;GGSFGGR;IETIEVMEDR;IETIEVMEDRQSGKK;MEGHDPK 6 13.8 0.0087719 1.0783 12.667 10.8396 10.2916 0 0 0 0 11.7446 0 8.33262 7.93026 10.7166 P51993 FUT6_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase) FUT6 FCT3A Homo sapiens (Human) ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; oligosaccharide biosynthetic process [GO:0009312]; oocyte axis specification [GO:0007309]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; methylosome [GO:0034709] 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] LPEASPA;WRETLRPR 2 4.1 0.71032 0.15906 0 0 0 0 0 0 0 0 0 0 8.67433 0 P52179 MYOM1_HUMAN Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) MYOM1 Homo sapiens (Human) extraocular skeletal muscle development [GO:0002074]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; sarcomere organization [GO:0045214] M band [GO:0031430]; striated muscle myosin thick filament [GO:0005863] identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] ASAMNVK;DAGIYEVILKDDR;DEREISVDEK;GQVRFWMQAEK;LQKEAEFQRQEWIR 5 3.3 0.97433 -1.3944 0 0 0 8.56415 11.1101 0 10.6889 0 0 0 0 10.8035 P52209 6PGD_HUMAN "6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" PGD PGDH Homo sapiens (Human) "D-gluconate catabolic process [GO:0046177]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]" cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616] GILFVGSGVSGGEEGAR;IISYAQGFMLLR;KPRRIILLVK;KSFLEDIR;TIFQGIAAK;TVSKVDDFLANEAK;VDDFLANEAK 7 14.5 0.13304 0.35646 10.874 11.0079 7.08311 9.09674 8.48957 7.81801 3.35643 0 0 10.6686 11.2099 10.6987 P52272 HNRPM_HUMAN Heterogeneous nuclear ribonucleoprotein M (hnRNP M) HNRNPM HNRPM NAGR1 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]; synapse [GO:0045202] mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] AAEVLNK;AAGVEAAAEVAATEIK;ADILEDKDGK;FEPYANPTK;FESPEVAER;FGSGMNMGR;GNFGGSFAGSFGGAGGHAPGVAR;IGSGVER;INEILSNALK;LGGAGMER;MAAPIDR;MATGLER;MGAGMGFGLER;MGANNLER;MGANSLER;MGGMEGPFGGGMENMGRFGSGMNMGR;MGLAMGGGGGASFDR;MGLSMER;MGLVMDR;MGPAIER;MGPAMGPALGAGIER;MGPGIDR;MGPVMDR;MGQTMER;MGSGVER;MVPAGMGAGLER;NLPFDFTWK;QGGGGGGGSVPGIER;SKGCGVVKFESPEVAER;VGQTIER;VGSEIER 31 42.6 0 69.139 14.156 14.0444 13.1906 10.4023 10.7546 9.75445 13.7093 11.4402 13.3974 13.6471 14.0252 12.0006 P52292 IMA1_HUMAN Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) KPNA2 RCH1 SRP1 Homo sapiens (Human) DNA metabolic process [GO:0006259]; entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of type I interferon production [GO:0032481]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; regulation of DNA recombination [GO:0000018] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723] GINSSNVENQLQATQAAR;LLGASELPIVTPALR;NKNPAPPIDAVEQILPTLVR;NPAPPIDAVEQILPTLVR;STNENANTPAAR;TGVVPQLVK 6 14 0 32.766 10.8322 11.5876 10.8389 8.45158 9.36958 9.18859 0 9.54417 10.0629 0 0 8.11894 P52294 IMA5_HUMAN "Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]" KPNA1 RCH2 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607]; postsynapse to nucleus signaling pathway [GO:0099527]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA recombination [GO:0000018]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell proliferation [GO:0014841] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] SPEQQLSATQK;VVSPALR 2 3.3 0.91141 -0.28556 0 0 0 6.19615 0 0 0 0 0 0 0 0 P52298 NCBP2_HUMAN Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) NCBP2 CBP20 PIG55 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; snRNA binding [GO:0017069] TDWDAGFK 1 5.1 0.91517 -0.37866 0 7.82279 0 0 0 0 0 0 0 0 0 0 P52306 GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) RAP1GDS1 SMGGDS Homo sapiens (Human) angiotensin-activated signaling pathway involved in heart process [GO:0086098]; CAAX-box protein maturation [GO:0080120]; cardiac muscle hypertrophy [GO:0003300]; myosin filament assembly [GO:0031034]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein localization to nucleus [GO:0034504]; regulation of ERK5 cascade [GO:0070376]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of mitochondrion organization [GO:0010821]; vascular associated smooth muscle contraction [GO:0014829] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085] LLGTLRMLIDAQEAAEQLGKNVK 1 3.8 0.59649 0.17852 0 5.03633 0 0 0 0 0 0 0 0 0 0 P52333 JAK3_HUMAN Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) JAK3 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; innate immune response [GO:0045087]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL production [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of thymocyte apoptotic process [GO:0070244]; regulation of apoptotic process [GO:0042981]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713] IPWVAPECLR 1 0.9 0.79561 0.015503 0 0 0 7.68762 0 0 0 0 0 0 0 0 P52435 RPB11_HUMAN DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit) POLR2J POLR2J1 Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366] "nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; LRR domain binding [GO:0030275]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055] DTKVPNACLFTINK 1 12 0.98052 -1.6154 0 0 0 0 0 0 0 0 0 0 0 11.8989 P52564 MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) "apoptotic process [GO:0006915]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; MAPK cascade [GO:0000165]; negative regulation of cold-induced thermogenesis [GO:0120163]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; osteoblast differentiation [GO:0001649]; ovulation cycle process [GO:0022602]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of prostaglandin secretion [GO:0032308]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]" cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] MSQSKGK;SQSKGKK 2 2.4 0.97287 -1.3742 0 9.0965 0 0 0 0 7.30788 0 0 0 0 0 P52565 GDIR1_HUMAN Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) ARHGDIA GDIA1 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; regulation of protein localization [GO:0032880]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic vesicle cycle [GO:0098693]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685] GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094] AEEYEFLTPVEEAPK;IDKTDYMVGSYGPR;SIQEIQELDK;SIQEIQELDKDDESLRK 4 22.5 0 2.5291 0 7.24251 0 8.86372 8.77666 8.76115 0 10.9043 12.263 0 0 10.405 P52566 GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) ARHGDIB GDIA2 GDID4 RAP1GN1 Homo sapiens (Human) cellular response to redox state [GO:0071461]; negative regulation of trophoblast cell migration [GO:1901164]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; Rho GDP-dissociation inhibitor activity [GO:0005094]; small GTPase binding [GO:0031267] DIVSGLK;DIVSGLKYVQHTYR;IHFKVNR 3 10.4 0.97647 -2.1831 0 12.07 0 0 0 0 0 0 0 0 0 8.99229 P52569 CTR2_HUMAN Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) SLC7A2 ATRC2 CAT2 Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104] cell junction [GO:0030054]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] IVTLDSLEDTK;QIGQFLRTYFR;VIYAMAEDGLLFK;VTSKSESQVTMLQR 4 7.4 0.95429 -0.91211 0 0 0 0 0 8.35733 11.5744 11.4458 11.4627 0 6.74066 0 P52594 AGFG1_HUMAN Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) AGFG1 HRB RAB RIP Homo sapiens (Human) acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; mRNA export from nucleus [GO:0006406]; spermatid nucleus differentiation [GO:0007289] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear pore [GO:0005643] DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] KQEEKHLK 1 1.4 0.97581 -1.4851 0 0 0 0 10.4999 0 4.03571 0 0 0 10.8556 0 P52597 HNRPF_HUMAN "Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]" HNRNPF HNRPF Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] ATENDIYNFFSPLNPVR;ITGEAFVQFASQELAEK;MLGPEGGEGFVVK;QSGEAFVELGSEDDVK;SYSDPPLK;TEMDWVLK;VTGEADVEFATHEEAVAAMSK 7 24.1 0 18.019 12.2232 11.43 12.2871 8.26566 0 11.0325 0 0 8.32057 11.9751 8.88246 0 P52630 STAT2_HUMAN Signal transducer and activator of transcription 2 (p113) STAT2 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response [GO:0006952]; defense response to virus [GO:0051607]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-like protein ligase binding [GO:0044389]" ALLGRLTTLIELLLPK;FLYPRIPR 2 2.8 0.97889 -2.0518 0 5.15064 3.59967 0 0 0 0 0 0 0 0 9.65397 P52701 MSH6_HUMAN DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) MSH6 GTBP Homo sapiens (Human) determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; response to UV [GO:0009411]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; MutSalpha complex [GO:0032301]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]; methylated histone binding [GO:0035064]; mismatched DNA binding [GO:0030983]" ETPSATK;LANLPEEVIQK;TLRTLLEEEYFREK;VTGNGSLK 4 3.8 0.96164 -1.074 0 7.0505 0 0 0 0 0 8.80038 0 0 0 0 P52732 KIF11_HUMAN Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) KIF11 EG5 KNSL1 TRIP5 Homo sapiens (Human) cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; spindle elongation [GO:0051231]; spindle organization [GO:0007051] cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle pole [GO:0000922] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901] ETTIDGEELVK;TPHVPYR;TYTFDMVFGASTK;VTELFMDNK 4 3.8 0.98047 -1.5492 0 0 0 0 0 0 0 10.5246 7.53597 0 0 0 P52735 VAV2_HUMAN Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphotyrosine residue binding [GO:0001784] DFGKVISAVSR;LEEFGRPK;LQDLLVVPMQRVLKYHLLLK;MGMTEDDKR;QLDTTLKYPYKSR 5 6.9 0.96501 -1.1215 11.9138 11.5486 0 0 8.20158 0 0 0 0 0 8.16012 0 P52736 ZN133_HUMAN Zinc finger protein 133 (Zinc finger protein 150) ZNF133 ZNF150 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" MTNLLSHQR;QCGLGFGNKSALITHKR 2 4 0.87302 -0.11503 0 0 0 0 0 0 0 8.04636 0 0 8.46809 0 P52737 ZN136_HUMAN Zinc finger protein 136 ZNF136 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NLYRDVMWETMR;NQCWKPFSSHHSFR 2 4.8 0.91853 -0.43638 0 0 0 6.05713 0 0 0 0 3.6248 0 0 0 P52738 ZN140_HUMAN Zinc finger protein 140 ZNF140 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DLFSVSESSGEIK 1 2.8 0.79645 0.01506 0 0 0 0 0 0 10.531 0 0 0 0 0 P52740 ZN132_HUMAN Zinc finger protein 132 ZNF132 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HEKVHTGERPFECLK;TYECSQCGK 2 3.4 0.93442 -0.50363 0 8.63898 0 0 10.192 0 0 0 0 0 0 0 P52741 ZN134_HUMAN Zinc finger protein 134 ZNF134 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SEASIVK;TFSRKDNLTQHK 2 4.4 0.96617 -1.2848 0 0 0 0 8.64569 0 0 0 0 0 0 0 P52742 ZN135_HUMAN Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) ZNF135 ZNF61 ZNF78L1 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSQSSLLIEHQRIHTK;AFTHSSSLTK;NSSALTKHQR 3 5.6 0.97454 -2.4386 0 0 12.5401 0 0 0 0 7.25333 0 0 0 0 P52744 ZN138_HUMAN Zinc finger protein 138 ZNF138 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ENFYKCEECGK 1 4.2 0.29327 0.25293 0 10.9471 7.91594 4.12391 0 0 0 0 0 11.0618 11.3386 0 P52746 ZN142_HUMAN Zinc finger protein 142 ZNF142 KIAA0236 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CTDCAYSTK;DVSYLSKHMLTHSNTK;DYMCTECGYVTK;GGRGGGGK;HLKETHGVRAVECR;HREARAFMCEQCGK;QDKEQAEALVLEGR;SLMCEVCAFACK;YQCNQCSYR 9 6.4 0.94142 -0.6026 12.7575 8.29912 7.68671 0 0 0 0 10.1353 0 7.03562 11.8324 0 P52756 RBM5_HUMAN RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) RBM5 H37 LUCA15 Homo sapiens (Human) "apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; spliceosomal complex assembly [GO:0000245]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GAGLGAK;HIAMHYSNPRPK 2 2.3 0.80372 0.012729 0 0 0 10.1968 9.16307 0 0 0 0 0 0 0 P52757 CHIO_HUMAN Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) CHN2 ARHGAP3 BCH Homo sapiens (Human) acrosome assembly [GO:0001675]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] EVENRPK 1 1.5 0.90932 -0.31529 0 0 0 0 0 0 0 0 9.86205 0 0 0 P52788 SPSY_HUMAN Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) SMS Homo sapiens (Human) methionine metabolic process [GO:0006555]; polyamine metabolic process [GO:0006595]; spermine biosynthetic process [GO:0006597] cytosol [GO:0005829]; extracellular exosome [GO:0070062] spermine synthase activity [GO:0016768] AIMGSGK 1 1.9 0.82291 -0.017925 0 11.0889 0 0 0 0 0 0 0 0 0 0 P52789 HXK2_HUMAN Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) HK2 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; lactation [GO:0007595]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of type 2 mitophagy [GO:1905091]; regulation of D-glucose import [GO:0046324]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931] centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396] MAKEELLFGGK;STIGVDGSVYK 2 2.4 0.954 -0.95309 0 0 0 0 0 0 0 0 11.335 0 0 0 P52790 HXK3_HUMAN Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) HK3 Homo sapiens (Human) canonical glycolysis [GO:0061621]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396] EQQTLQVAVATGGR;GLRGEASSLR 2 2.6 0.97184 -1.3544 0 7.75208 0 0 0 0 0 0 0 0 11.4535 0 P52798 EFNA4_HUMAN Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) EFNA4 EPLG4 LERK4 Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005] GGDTPSPLCLLLLLLLLILRLLR 1 11.4 0.83432 -0.029624 0 0 8.57652 0 0 0 0 0 0 0 0 0 P52798 EFNA4_HUMAN Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) EFNA4 EPLG4 LERK4 Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005] QDGALMGEIR;VLPRSPGGGGIPAACTGGANSDR 2 15.9 0.94697 -0.66019 0 0 0 0 0 8.57111 0 0 0 0 0 10.9261 P52799 EFNB2_HUMAN Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) EFNB2 EPLG5 HTKL LERK5 Homo sapiens (Human) adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; keratinocyte proliferation [GO:0043616]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron projection development [GO:0010977]; nephric duct morphogenesis [GO:0072178]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; presynapse assembly [GO:0099054]; regulation of chemotaxis [GO:0050920]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845] adherens junction [GO:0005912]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618] FQEFSPNLWGLEFQK;LDIICPK;LDIICPKVDSK;TAISKSIVLEPIYWNSSNSK 4 13.8 0.98096 -1.7366 6.75515 5.25856 11.988 0 0 0 5.95224 9.84277 6.53239 8.62136 0 0 P52803 EFNA5_HUMAN Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7) EFNA5 EPLG7 LERK7 Homo sapiens (Human) axon guidance [GO:0007411]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to forskolin [GO:1904322]; collateral sprouting [GO:0048668]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; nervous system development [GO:0007399]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell morphogenesis [GO:0022604]; regulation of cell-cell adhesion [GO:0022407]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of microtubule cytoskeleton organization [GO:0070507]; retinal ganglion cell axon guidance [GO:0031290]; synaptic membrane adhesion [GO:0099560] adherens junction [GO:0005912]; basement membrane [GO:0005604]; caveola [GO:0005901]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; ephrin receptor binding [GO:0046875]; neurotrophin TRKA receptor binding [GO:0005168]; neurotrophin TRKB receptor binding [GO:0005169]; neurotrophin TRKC receptor binding [GO:0005170]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] TIGVHDR;TIGVHDRVFDVNDK 2 6.1 0.95668 -0.85013 0 0 0 0 0 0 0 0 0 0 8.65062 0 P52815 RM12_HUMAN "Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) (L12mt) (MRP-L12) (5c5-2) [Cleaved into: Large ribosomal subunit protein bL12m, long mature form; Large ribosomal subunit protein bL12m, short mature form]" MRPL12 MRPL7 RPML12 Homo sapiens (Human) mitochondrial transcription [GO:0006390]; mitochondrial translation [GO:0032543]; positive regulation of DNA-templated transcription [GO:0045893]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LVESLPQEIK 1 5.1 0.92942 -0.48117 0 8.72748 0 0 0 0 0 0 0 0 0 0 P52824 DGKQ_HUMAN Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) DGKQ DAGK4 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to bile acid [GO:1903413]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cholesterol metabolic process [GO:0090181]; regulation of cortisol biosynthetic process [GO:2000064]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of gluconeogenesis [GO:0006111]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of TORC1 signaling [GO:1903432]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; thrombin-activated receptor signaling pathway [GO:0070493] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; vesicle membrane [GO:0012506] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; DNA-binding transcription factor binding [GO:0140297]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] ISHSRSLHKQIR;LAGAEEVLEAALR;QAESPESFQLVEVAMGCR 3 4.6 0.97811 -1.9319 0 0 0 0 10.0843 0 12.2656 0 0 10.1849 0 0 P52849 NDST2_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)] NDST2 HSST2 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mast cell mediated immunity [GO:0002448]; regulation of angiotensin levels in blood [GO:0002002]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119] GAALLPRAK;TLVPNFTFNLGFSGK;VLFGHGLSFWLHK 3 4.2 0.96717 -1.316 0 0 0 0 0 0 0 0 12.6438 8.11723 0 0 P52888 THOP1_HUMAN Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) THOP1 Homo sapiens (Human) peptide metabolic process [GO:0006518]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ETQENIK;HYRTGSAVPRELLEK;LSEFDVEMSMR 3 4.8 0.91417 -0.33799 0 0 0 0 4.61182 6.42527 7.25181 0 0 0 0 8.65227 P52895 AK1C2_HUMAN Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) AKR1C2 DDH2 Homo sapiens (Human) cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; steroid metabolic process [GO:0008202] cytosol [GO:0005829] "aldose reductase (NADPH) activity [GO:0004032]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]" AIDGLNR;EDIFYTSK;GVVVLAK;LLEMILNKPGLK;LNDGHFMPVLGFGTYAPAEVPK;REDIFYTSK;SIGVSNFNHR;TPALIALR 8 23.2 0 5.5113 10.7679 0 0 0 0 0 13.2981 12.9678 13.244 7.23831 12.8551 0 P52943 CRIP2_HUMAN Cysteine-rich protein 2 (CRP-2) (Protein ESP1) CRIP2 CRP2 Homo sapiens (Human) hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284] cell cortex [GO:0005938] zinc ion binding [GO:0008270] DWHKFCLK;GGGCCHR 2 5.3 0.97831 -1.9247 0 0 0 0 0 0 0 0 9.36931 0 5.46271 0 P52948 NUP98_HUMAN Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] NUP98 ADAR2 Homo sapiens (Human) "mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398]" cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nuclear localization sequence binding [GO:0008139]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056]; transcription coactivator activity [GO:0003713] AGVSTNISTK;ELAVGSL;ELLTRHCQLLETPESWAK;EYIQILER;FTSGAFLSPSVSVQECR;LPISASHSSK 6 3.9 0.95423 -0.89811 8.15967 12.8606 8.24551 0 0 0 9.63815 11.1512 10.8424 7.74457 12.6886 0 P52952 NKX25_HUMAN Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) NKX2-5 CSX NKX2.5 NKX2E Homo sapiens (Human) adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular node development [GO:0003162]; bundle of His development [GO:0003166]; cardiac conduction system development [GO:0003161]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; proepicardium development [GO:0003342]; pulmonary myocardium development [GO:0003350]; Purkinje myocyte differentiation [GO:0003168]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cardiac muscle contraction [GO:0055117]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; cytoplasm [GO:0005737]; Nkx-2.5 complex [GO:1990664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" IAVPVLVR;SLAAAGELSAR 2 5.9 0.92435 -0.44852 0 0 0 14.4892 10.0297 0 0 0 12.0428 18.1681 0 0 P52954 LBX1_HUMAN Transcription factor LBX1 (Ladybird homeobox protein homolog 1) LBX1 LBX1H Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell population proliferation [GO:0008283]; glutamatergic neuron differentiation [GO:1905962]; heart looping [GO:0001947]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glutamatergic neuron differentiation [GO:0120007]; neuron fate determination [GO:0048664]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord motor neuron differentiation [GO:0021522] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" RFLYQKYLSPADR 1 4.6 0.58782 0.17868 0 0 6.78464 0 0 0 0 0 0 0 0 0 P53007 TXTP_HUMAN "Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)" SLC25A1 SLC20A3 Homo sapiens (Human) mitochondrial citrate transmembrane transport [GO:0006843]; monoatomic ion transport [GO:0006811] extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142] EQGLKGTYQGLTATVLK;FIHDQTSPNPK;FIHDQTSPNPKYRGFFHGVR;YRNTWDCGLQILK 4 16.1 0.96292 -1.1022 0 0 0 4.95145 0 0 0 8.85773 0 9.45094 0 0 P53041 PPP5_HUMAN Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT) PPP5C PPP5 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; MAPK cascade [GO:0000165]; mitotic cell cycle [GO:0000278]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein dephosphorylation [GO:0006470]; response to arachidonate [GO:1904550]; response to lead ion [GO:0010288]; response to morphine [GO:0043278] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991] ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; tau protein binding [GO:0048156] LSTLVETTLKETEK 1 2.8 0.95211 -0.70747 0 0 0 0 0 0 0 0 0 9.60774 0 0 P53350 PLK1_HUMAN Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) PLK1 PLK Homo sapiens (Human) centrosome cycle [GO:0007098]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; establishment of mitotic spindle orientation [GO:0000132]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi inheritance [GO:0048313]; homologous chromosome segregation [GO:0045143]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear membrane disassembly [GO:0051081]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of anaphase-promoting complex-dependent catabolic process [GO:1905784]; regulation of cell cycle [GO:0051726]; regulation of cytokinesis [GO:0032465]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein binding [GO:0043393]; regulation of protein localization to cell cortex [GO:1904776]; sister chromatid cohesion [GO:0007062]; synaptonemal complex disassembly [GO:0070194] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synaptonemal complex [GO:0000795] anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] AGANITPR;IVPKSLLLKPHQR;LPYLRTWFR;SLLELHKR;SLLLKPHQR;VEYDGERKK;YARTMVDK 7 9.1 0.97517 -3.9672 0 0 0 5.74206 7.73566 0 0 9.69323 6.4294 0 9.6961 0 P53355 DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to hydroperoxide [GO:0071447]; cellular response to type II interferon [GO:0071346]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagic cell death [GO:1904094]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of NMDA receptor activity [GO:2000310]; regulation of response to tumor cell [GO:0002834] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; DAPK1-calmodulin complex [GO:1990722]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; syntaxin-1 binding [GO:0017075] IISTLPSWR 1 0.6 0.90915 -0.31585 0 0 0 0 0 0 0 0 0 0 8.90845 0 P53365 ARFP2_HUMAN Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1) ARFIP2 POR1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; intracellular protein transport [GO:0006886]; lamellipodium assembly [GO:0030032]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; small GTPase-mediated signal transduction [GO:0007264] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; trans-Golgi network membrane [GO:0032588] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267] QLLSERFGR 1 2.6 0.98094 -1.5748 0 0 0 10.6466 0 0 0 0 0 0 0 0 P53367 ARFP1_HUMAN Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) ARFIP1 Homo sapiens (Human) "intracellular protein transport [GO:0006886]; negative regulation of retrograde transport, endosome to Golgi [GO:1905280]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein secretion [GO:0050708]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588] phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904] IEQSQHLFQAHK;LELVRKWSLNTYK 2 6.7 0.98117 -1.7568 0 0 0 7.71946 8.08502 7.76779 0 9.71044 0 0 0 0 P53384 NUBP1_HUMAN Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1) NUBP1 NBP NBP1 Homo sapiens (Human) cell projection organization [GO:0030030]; centrosome localization [GO:0051642]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of centrosome duplication [GO:0010826]; protein localization to cell cortex [GO:0072697]; regulation of cell growth [GO:0001558] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" ILVLSGK 1 2.2 0.90838 -0.31341 0 0 0 0 0 0 0 0 0 6.50398 0 0 P53396 ACLY_HUMAN ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) ACLY Homo sapiens (Human) acetyl-CoA biosynthetic process [GO:0006085]; cholesterol biosynthetic process [GO:0006695]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; metal ion binding [GO:0046872] AFDSGIIPMEFVNK;AIVWGMQTR;DGVYVLDLAAK;EAYPEEAYIADLDAK;EILIPVFK;LGQEATVGK;NMADAMRK;SGGMSNELNNIISR;SLQGKSTTLFSRHTK;TIAIIAEGIPEALTR;TILSLMTR;VQILKDYVRQHFPATPLLDYALEVEK;WGDIEFPPPFGR;YQDTPGVK 14 15.6 0 9.3326 9.78423 10.7923 0 8.17772 8.3587 7.29719 15.6467 0 8.93434 10.903 11.1408 12.7066 P53420 CO4A4_HUMAN Collagen alpha-4(IV) chain COL4A4 Homo sapiens (Human) glomerular basement membrane development [GO:0032836] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090] VGPPGGRGPK 1 0.6 0.98056 -1.5739 0 0 0 0 0 0 0 0 0 0 0 12.1293 P53539 FOSB_HUMAN "Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)" FOSB G0S3 Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; cellular response to calcium ion [GO:0071277]; cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to mechanical stimulus [GO:0009612]; response to morphine [GO:0043278]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AELESEIAELQKEK 1 4.1 0.882 -0.17929 0 0 0 8.36934 0 0 0 0 0 0 0 0 P53582 MAP11_HUMAN Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) METAP1 KIAA0094 Homo sapiens (Human) N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; platelet aggregation [GO:0070527]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235] LLHKKAK;LQCPTCIK;LVCRLAR 3 5.7 0.95297 -0.76325 0 0 0 0 3.69086 0 0 0 0 0 6.90593 0 P53597 SUCA_HUMAN "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)" SUCLG1 Homo sapiens (Human) succinyl-CoA catabolic process [GO:1901289]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; succinate-CoA ligase complex (GDP-forming) [GO:0045244] nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] GGQTHLGLPVFNTVK 1 4.3 0.80636 0.012236 12.5128 0 0 0 0 0 0 0 0 0 0 0 P53602 MVD1_HUMAN Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) MVD MPD Homo sapiens (Human) "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284]" cytosol [GO:0005829] ATP binding [GO:0005524]; diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803] ASVETSPLLR 1 2.5 0.91703 -0.41933 0 11.3216 0 0 0 0 0 0 0 0 0 0 P53618 COPB_HUMAN Coatomer subunit beta (Beta-coat protein) (Beta-COP) COPB1 COPB MSTP026 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] EAADPLASK;KDLQHPNEFIR;SLGEIPIVESEIK 3 3.5 0.96781 -1.3204 0 0 0 0 0 0 11.8841 0 0 12.5913 0 0 P53621 COPA_HUMAN Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] COPA Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133] hormone activity [GO:0005179]; structural molecule activity [GO:0005198] DADSITLFDVQQK;DVAVMQLR;FETKSARVK;GYPEVALHFVKDEK;KYDEVLHMVRNAK;LERERPAYAVHGNMLHYVK;NLSPGAVESDVR;QQPLFVSGGDDYK;TAATFAR;TALNLFFK;YDEVLHMVR 11 9.5 0.97503 -4.1597 15.7335 0 0 11.1485 13.829 13.545 11.9517 0 15.0223 8.51625 10.8629 9.19965 P53634 CATC_HUMAN Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC CPPI Homo sapiens (Human) immune response [GO:0006955]; negative regulation of myelination [GO:0031642]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; T cell mediated cytotoxicity [GO:0001913] azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] chloride ion binding [GO:0031404]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; peptidase activator activity involved in apoptotic process [GO:0016505]; phosphatase binding [GO:0019902]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252] VGTASENVYVNIAHLK 1 3.5 0.78036 0.033781 0 0 0 0 0 0 0 0 0 10.8994 0 0 P53667 LIMK1_HUMAN LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) LIMK1 LIMK Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nervous system development [GO:0007399]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon extension [GO:0045773]; positive regulation of stress fiber assembly [GO:0051496]; protein phosphorylation [GO:0006468]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynapse [GO:0098794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heat shock protein binding [GO:0031072]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CCDCSASLSHQYYEK;DLGRSESLR 2 3.7 0.96714 -1.3078 0 0 10.5726 0 0 0 0 0 0 0 0 4.77004 P53671 LIMK2_HUMAN LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) LIMK2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; astral microtubule organization [GO:0030953]; cornea development in camera-type eye [GO:0061303]; establishment of vesicle localization [GO:0051650]; head development [GO:0060322]; negative regulation of cilium assembly [GO:1902018]; phosphorylation [GO:0016310]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELIRCDEETQKTFLTEVK;FVPTDCPPAFFPLAAICCR;SNSISKSPGPSSPK 3 8 0.9411 -0.5901 0 0 0 7.87197 8.96064 7.28272 0 0 5.74435 0 0 0 P53674 CRBB1_HUMAN Beta-crystallin B1 (Beta-B1 crystallin) CRYBB1 Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] ASASATVAVNPGPDTK 1 6.3 0.89299 -0.21819 0 0 0 0 0 0 0 0 10.4366 0 0 0 P53675 CLH2_HUMAN Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) CLTCL1 CLH22 CLTCL CLTD Homo sapiens (Human) "anatomical structure morphogenesis [GO:0009653]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; positive regulation of D-glucose import [GO:0046326]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147]" clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; coated vesicle [GO:0030135]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; membrane [GO:0016020]; sorting endosome [GO:0097443]; spindle [GO:0005819]; trans-Golgi network [GO:0005802] clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198] AYEFAER;DPHLACVAYERGQCDLELIKVCNENSLFK;FICIREK;GQFSTDELVAEVEK;IYIDSNNSPECFLR;NLQNLLILTAIK;NLQNLLILTAIKADRTR;VVGAMQLYSVDR;YIEIYVQK 9 6.6 0.60948 0.17525 0 0 0 0 0 0 0 9.61629 0 0 0 0 P53701 CCHL_HUMAN Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) HCCS CCHL Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]; respiratory electron transport chain [GO:0022904] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872] EESSIPRADSEKK;HDWIINRCGTEVR;KWVYPSEQMFWNAMLKK;VAWWRWTS 4 18.7 0.98123 -1.7104 0 0 0 0 0 4.24154 0 0 9.15995 5.34706 0 0 P53708 ITA8_HUMAN Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; metanephros development [GO:0001656]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179] apical part of cell [GO:0045177]; cell surface [GO:0009986]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] integrin binding [GO:0005178]; metal ion binding [GO:0046872] DVHVVEFHRQSPAK;TLKPTPEK 2 2.1 0.96541 -1.2467 11.7564 0 0 9.47078 0 0 0 0 0 0 0 11.5468 P53778 MK12_HUMAN Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) MAPK12 ERK6 SAPK3 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; negative regulation of cell cycle [GO:0045786]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of peptidase activity [GO:0010952]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] GLPELEK;TLDEWKR;WYRAPEVILNWMR 3 7.4 0.98137 -1.7729 0 0 0 0 0 8.67716 0 4.55379 0 0 0 0 P53779 MK10_HUMAN Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) MAPK10 JNK3 JNK3A PRKM10 SAPK1B Homo sapiens (Human) cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; response to light stimulus [GO:0009416]; rhythmic process [GO:0048511]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310] TAGTSFMMTPYVVTR;TKNGVVK 2 4.7 0.9799 -1.5647 0 0 0 0 0 0 12.504 0 0 0 0 0 P53804 TTC3_HUMAN E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) TTC3 DCRR1 RNF105 TPRD Homo sapiens (Human) protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] AKSQFEEQIK;DLIQQHVKLQKQIEDLQGR;DPAAYPDMESDIR;IEFHMNCWK;IGCKIENK;ISCCQYCK;ISCCQYCKIEFHMNCWKK;LAAWIQK;NDPEGIKDLIQQHVKLQK;RHLEENK;VANDSFLIGGLLRIGCK;VIKEKVPPRPILK;VLKCGHKYHK;VPPRPILK;VTEHILDEQK;VTEHILDEQKKK;YHKGCFK 17 7 0.97818 -6.3807 12.4417 9.9116 0 9.4496 0 5.12474 10.2133 10.0309 7.11697 15.5398 6.36554 11.2206 P53814 SMTN_HUMAN Smoothelin SMTN SMSMO Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517]; smooth muscle contraction [GO:0006939] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815] actin binding [GO:0003779]; structural constituent of muscle [GO:0008307] AGSVRDR;ELQRQELER;ETPAAQSPTRGPSDTK;SLSVLSPRQPAQNR 4 5 0.97401 -3.0003 8.49173 7.64342 0 0 0 0 0 0 0 7.5672 0 9.0007 P53816 PLAT3_HUMAN Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65) PLAAT3 HRASLS3 HREV107 PLA2G16 Homo sapiens (Human) ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; response to bacterium [GO:0009617]; triglyceride metabolic process [GO:0006641] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] acyltransferase activity [GO:0016746]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lipid binding [GO:0008289]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] YGVARSDQVR 1 6.2 0.92371 -0.44918 0 0 0 0 0 8.19594 0 0 0 0 0 0 P53990 IST1_HUMAN IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) IST1 KIAA0174 Homo sapiens (Human) cell division [GO:0051301]; collateral sprouting [GO:0048668]; cytoskeleton-dependent cytokinesis [GO:0061640]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; multivesicular body assembly [GO:0036258]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031] azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nuclear envelope [GO:0005635] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877] IVADQLCAK;LCRTNQIGTVNDR;LMHKLSVEAPPKILVER 3 10.7 0.95651 -0.84649 0 10.8073 0 0 0 6.65964 9.53158 11.5278 0 0 0 10.8561 P53992 SC24C_HUMAN Protein transport protein Sec24C (SEC24-related protein C) SEC24C KIAA0079 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] DVQKVVGFDAVMR;GVLNSPVK 2 1.9 0.9541 -0.95329 12.2991 0 0 0 0 0 0 0 0 4.04675 0 0 P53999 TCP4_HUMAN Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) SUB1 PC4 RPO2TC1 Homo sapiens (Human) negative regulation of DNA duplex unwinding [GO:1905463]; negative regulation of DNA metabolic process [GO:0051053]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II promoter clearance [GO:0001111] extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] DDNMFQIGK;EQISDIDDAVR 2 15.7 0 3.7007 0 0 10.2607 0 0 0 0 0 0 11.2397 10.3869 0 P54098 DPOG1_HUMAN DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) POLG MDP1 POLG1 POLGA Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA replication proofreading [GO:0045004]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]" gamma DNA polymerase complex [GO:0005760]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial chromosome [GO:0000262]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] 3'-5' exonuclease activity [GO:0008408]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310] CLRKEVTMDCK;FCISIHDEVR;LSDEGEWLVRELNLPVDR;LYVGGPPLEK;SRLLWRK;TATTVGISREHAK;WLFEEFAIDGRFCISIHDEVR 7 6.5 0.97491 -3.2244 11.6007 10.0616 10.3162 8.09439 7.88911 11.6269 9.07529 0 0 0 0 9.59761 P54105 ICLN_HUMAN "Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)" CLNS1A CLCI ICLN Homo sapiens (Human) "cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spliceosomal snRNP assembly [GO:0000387]" cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] GLGTGTLYIAESR;QQPDTEAVLNGK;SFPPPGPAEGLLR 3 16 0.0024631 1.6216 13.0887 11.2629 12.1985 8.88267 9.50218 0 0 0 0 0 0 0 P54107 CRIS1_HUMAN Cysteine-rich secretory protein 1 (CRISP-1) (AEG-like protein) (ARP) (Acidic epididymal glycoprotein homolog) CRISP1 AEGL1 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; regulation of acrosome reaction [GO:0060046] extracellular space [GO:0005615]; nucleus [GO:0005634] calcium channel regulator activity [GO:0005246] TGVPCEACPSNCEDK;YCDMTESNPLER 2 10.8 0.25548 0.27423 3.17068 8.86233 0 0 0 0 0 0 0 0 0 0 P54108 CRIS3_HUMAN Cysteine-rich secretory protein 3 (CRISP-3) (Specific granule protein of 28 kDa) (SGP28) CRISP3 Homo sapiens (Human) defense response [GO:0006952]; innate immune response [GO:0045087] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] LYVPYEQGAPCASCPDNCDDGLCTNGCK 1 11.4 0.71429 0.14212 0 7.00011 0 0 0 5.14588 0 0 0 0 0 0 P54132 BLM_HUMAN "RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)" BLM RECQ2 RECQL3 Homo sapiens (Human) cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell division [GO:0051782]; negative regulation of DNA recombination [GO:0045910]; positive regulation of DNA-templated transcription [GO:0045893]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of DNA-templated DNA replication [GO:0090329]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; response to X-ray [GO:0010165]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; RecQ family helicase-topoisomerase III complex [GO:0031422]; replication fork [GO:0005657] "3'-5' DNA helicase activity [GO:0043138]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; zinc ion binding [GO:0008270]" AAVPQNNLQEQLER;AQTVLNGNLKVDFMETENSSSVK;CLSTLKDLDTSDRK;ECDTMADTLQR;EVVCTTQNTPTVK;HPDVSCDNCCK;LFKKLILDK;LIMMEKDGNHHTR;LLTEVDFNK;TASSGSK 10 8.8 0.97308 -2.9148 0 0 13.0688 9.23499 0 0 10.9961 0 12.0014 8.57984 7.1643 0 P54136 SYRC_HUMAN "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS1 RARS Homo sapiens (Human) arginyl-tRNA aminoacylation [GO:0006420]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] arginine binding [GO:0034618]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; tRNA binding [GO:0000049] ETKILLDHEKEWK;LANIDEEMLQK;LLQQEEEIK;SLQAERNKPTKNMINIISR;VEIAGPGFINVHLR 5 10 0.0047059 1.4081 0 0 10.6847 0 9.90652 0 0 0 0 8.58391 10.3999 0 P54136 SYRC_HUMAN "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS1 RARS Homo sapiens (Human) arginyl-tRNA aminoacylation [GO:0006420]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] arginine binding [GO:0034618]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; tRNA binding [GO:0000049] ETKILLDHEKEWK;INIISRLQEVFGHAIK;LANIDEEMLQK;VEIAGPGFINVHLR 4 9.2 0.93707 -0.56154 0 0 0 0 0 0 0 13.001 0 0 0 0 P54198 HIRA_HUMAN Protein HIRA (TUP1-like enhancer of split protein 1) HIRA DGCR1 HIR TUPLE1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] IEPMKAFDSR;IHQSTYGK;LIMVWKR;RQQQQQLDQKSAATR;SLSVWLTCLKRPLVVIHELFDK 5 6.1 0.97322 -2.4867 7.39378 0 0 9.03768 0 10.1983 0 0 0 0 0 0 P54219 VMAT1_HUMAN Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1) SLC18A1 VAT1 VMAT1 Homo sapiens (Human) aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; dopamine uptake [GO:0090494]; monoamine transport [GO:0015844]; norepinephrine uptake [GO:0051620]; serotonin uptake [GO:0051610] clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; endoplasmic reticulum membrane [GO:0005789]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]; xenobiotic transmembrane transporter activity [GO:0042910] TILDAPQRLLK 1 2.1 0.88801 -0.18322 0 0 0 0 0 0 0 9.50222 0 0 0 0 P54252 ATX3_HUMAN Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) ATXN3 ATX3 MJD MJD1 SCA3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; chemical synaptic transmission [GO:0007268]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of TORC1 signaling [GO:1904262]; nervous system development [GO:0007399]; nucleotide-excision repair [GO:0006289]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex [GO:1904327]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cell-substrate adhesion [GO:0010810]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; ubiquitin protein ligase binding [GO:0031625] VQQMHRPKLIGEELAQLKEQR 1 5.8 0.95776 -1.0168 0 0 0 12.1997 0 11.638 0 0 0 0 0 0 P54257 HAP1_HUMAN Huntingtin-associated protein 1 (HAP-1) (Neuroan 1) HAP1 HAP2 HLP1 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; autophagy [GO:0006914]; brain development [GO:0007420]; cell projection organization [GO:0030030]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; hypothalamus cell differentiation [GO:0021979]; mitochondrion distribution [GO:0048311]; negative regulation of amyloid-beta formation [GO:1902430]; neurogenesis [GO:0022008]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotrophin production [GO:0032901]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; protein targeting [GO:0006605]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of organelle transport along microtubule [GO:1902513]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]" actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021] brain-derived neurotrophic factor binding [GO:0048403]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] TGARPASEAGAK 1 1.8 0.77474 0.048652 0 0 0 0 0 0 0 0 0 0 5.5777 0 P54259 ATN1_HUMAN Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) ATN1 D12S755E DRPLA Homo sapiens (Human) cell killing [GO:0001906]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; determination of adult lifespan [GO:0008340]; maintenance of cell polarity [GO:0030011]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; spermatogenesis [GO:0007283] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] EAEQRAREEK;FNKHLDR;SLNDDGSSDPRDIDQDNR 3 2.9 0.97277 -2.9544 0 0 11.2377 0 0 0 0 0 4.92505 9.30285 0 0 P54274 TERF1_HUMAN Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) TERF1 PIN2 TRBF1 TRF TRF1 Homo sapiens (Human) cell division [GO:0051301]; meiotic telomere clustering [GO:0045141]; negative regulation of DNA replication [GO:0008156]; negative regulation of establishment of protein localization to telomere [GO:1904850]; negative regulation of establishment of protein-containing complex localization to telomere [GO:1904914]; negative regulation of establishment of RNA localization to telomere [GO:1904911]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of shelterin complex assembly [GO:1904792]; positive regulation of telomere maintenance [GO:0032206]; response to xenobiotic stimulus [GO:0009410]; t-circle formation [GO:0090656]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; spindle [GO:0005819]" "ankyrin repeat binding [GO:0071532]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; double-stranded telomeric DNA binding [GO:0003691]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; telomeric DNA binding [GO:0042162]" YGEGNWSKILLHYKFNNR 1 4.1 0.95868 -1.0021 0 0 0 0 0 10.5253 0 0 0 0 0 0 P54277 PMS1_HUMAN PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) mismatch repair [GO:0006298]; response to xenobiotic stimulus [GO:0009410] MutLalpha complex [GO:0032389]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983] AIEQESQMSLKDGRK;TDVSAADIVLSK;TLSEEEK 3 3.6 0.95531 -0.96586 8.35636 0 0 0 7.63974 0 0 0 0 0 0 0 P54278 PMS2_HUMAN Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) PMS2 PMSL2 Homo sapiens (Human) mismatch repair [GO:0006298]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; response to xenobiotic stimulus [GO:0009410]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447] cytosol [GO:0005829]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; endonuclease activity [GO:0004519]; single base insertion or deletion binding [GO:0032138] ERAESSSTEPAK;QILLQEEK;QILLQEEKLLLAVLK;RQILLQEEKLLLAVLK;TDDSFSDVDCHSNQEDTGCK;YNFEMLQQHTVLQGQR 6 7.4 0.965 -1.2296 13.459 0 15.4362 5.7143 0 3.28045 6.53303 4.39225 7.32607 0 0 0 P54289 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] CACNA2D1 CACNL2A CCHL2A MHS3 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to amyloid-beta [GO:1904646]; membrane depolarization during bundle of His cell action potential [GO:0086048]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of calcium ion transport [GO:0051924]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; sarcoplasmic reticulum [GO:0016529]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] DPCAGPVCDCKR;IDVNSWIENFTKTSIR;TASGVNQLVDIYEK;TFRTLVKSQDER;TLVKSQDER;VQAAHQWR;YYPASPWVDNSRTPNK 7 7.1 0.97478 -3.9105 0 0 11.5439 0 0 9.29542 0 0 10.5987 10.861 10.2725 11.4189 P54296 MYOM2_HUMAN Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) MYOM2 Homo sapiens (Human) extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214] M band [GO:0031430]; mitochondrion [GO:0005739]; myosin filament [GO:0032982] kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307] ATLKDDR;LIPASASAAGQ;NDQDIQLSEHFSVKVEQAK;RASTQASSQK 4 3.2 0.97236 -2.7821 0 0 0 0 0 0 0 0 0 0 0 11.6826 P54315 LIPR1_HUMAN Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Homo sapiens (Human) lipid metabolic process [GO:0006629] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; triacylglycerol lipase activity [GO:0004806] CFPCPDQGCPQMGHYADKFAGR 1 4.7 0.92189 -0.44285 0 0 0 0 0 0 5.96253 0 0 0 0 0 P54317 LIPR2_HUMAN Pancreatic lipase-related protein 2 (PL-RP2) (Cytotoxic T lymphocyte lipase) (Galactolipase) (EC 3.1.1.26) (Triacylglycerol lipase) (EC 3.1.1.3) PNLIPRP2 PLRP2 Homo sapiens (Human) galactolipid catabolic process [GO:0019376]; lipid digestion [GO:0044241]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; triglyceride catabolic process [GO:0019433]; triglyceride metabolic process [GO:0006641] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; zymogen granule membrane [GO:0042589] calcium ion binding [GO:0005509]; galactolipase activity [GO:0047714]; monoacylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620]; triacylglycerol lipase activity [GO:0004806] CFPCPAEGCPK 1 2.3 0.30235 0.24998 0 0 0 0 0 0 0 10.1936 0 0 0 0 P54368 OAZ1_HUMAN Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az) OAZ1 OAZ Homo sapiens (Human) polyamine biosynthetic process [GO:0006596]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]; viral translational frameshifting [GO:0075523] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ornithine decarboxylase inhibitor activity [GO:0008073] ADHVFICFHKNR;ESSGEEEE 2 8.8 0.95621 -0.83835 0 0 0 0 0 0 0 0 0 0 0 9.9601 P54577 SYYC_HUMAN "Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]" YARS1 YARS Homo sapiens (Human) apoptotic process [GO:0006915]; response to starvation [GO:0042594]; tyrosyl-tRNA aminoacylation [GO:0006437] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear body [GO:0016604]; nucleus [GO:0005634] ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; RNA binding [GO:0003723]; small molecule binding [GO:0036094]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831] AMLESIGVPLEK;GTDYQLSK;IDVGEAEPR;IFTFAEK;LASAAYPDPSK;LSSVVTQHDSKK;QVEPLDPPAGSAPGEHVFVK 7 15 0.71611 0.1395 0 0 10.0945 8.09524 11.0192 0 0 11.5094 11.253 6.68748 0 0 P54578 UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) USP14 TGT Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; innate immune response [GO:0045087]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked deubiquitination [GO:0071108]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; proteasome complex [GO:0000502] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; endopeptidase inhibitor activity [GO:0004866]; K63-linked deubiquitinase activity [GO:0061578]; proteasome binding [GO:0070628] AQLFALTGVQPAR;QSPTLQR;VNQQPNTSDKK 3 6.3 0.060201 0.43677 11.9437 0 0 9.23766 0 0 10.1127 0 10.6977 0 0 0 P54619 AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) PRKAG1 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; import into nucleus [GO:0051170]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein kinase activity [GO:0045860]; protein phosphorylation [GO:0006468]; regulation of carbon utilization [GO:0043609]; regulation of glycolytic process [GO:0006110]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] AFFALVTNGVR 1 3.3 0.93648 -0.52503 0 0 0 0 0 10.9281 0 0 0 0 0 0 P54646 AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) PRKAA2 AMPK AMPK2 Homo sapiens (Human) autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CPLDALNTTKPK;SYLLDFK 2 3.4 0.90954 -0.31032 0 7.96203 0 0 0 0 0 0 0 8.58365 0 0 P54652 HSP72_HUMAN Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) HSPA2 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein refolding [GO:0042026]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex disassembly [GO:0070194] blood microparticle [GO:0072562]; CatSper complex [GO:0036128]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; meiotic spindle [GO:0072687]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; glycolipid binding [GO:0051861]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; unfolded protein binding [GO:0051082] ARFEELNADLFR;DNNLLGK;IINEPTAAAIAYGLDK;IINEPTAAAIAYGLDKK;ILDKCQEVINWLDR;ISEQDKNK;ITITNDK;ITITNDKGR;LLQDFFNGK;LLQDFFNGKELNK;NQVAMNPTNTIFDAKR;NTTIPTK;STAGDTHLGGEDFDNR;TACERAK;TTPSYVAFTDTER;TTPSYVAFTDTERLIGDAAK;VQVEYKGETK 17 24.4 0.96814 -1.3261 0 12.2204 0 9.0192 0 0 0 9.00211 0 12.5719 0 10.9627 P54687 BCAT1_HUMAN "Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42)" BCAT1 BCT1 ECA39 Homo sapiens (Human) branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; L-leucine biosynthetic process [GO:0009098]; L-valine biosynthetic process [GO:0009099]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine-2-oxoglutarate transaminase activity [GO:0052656]; L-leucine-2-oxoglutarate transaminase activity [GO:0052654]; L-valine-2-oxoglutarate transaminase activity [GO:0052655] MDCSNGCSAECTGEGGSK;SAVRATLPVFDK 2 7.8 0.8975 -0.23397 0 0 0 0 0 0 0 0 0 4.36737 0 0 P54687 BCAT1_HUMAN "Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42)" BCAT1 BCT1 ECA39 Homo sapiens (Human) branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; L-leucine biosynthetic process [GO:0009098]; L-valine biosynthetic process [GO:0009099]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine-2-oxoglutarate transaminase activity [GO:0052656]; L-leucine-2-oxoglutarate transaminase activity [GO:0052654]; L-valine-2-oxoglutarate transaminase activity [GO:0052655] QDCSNGCSAECTGEGGSK;SAVRATLPVFDK 2 7.5 0.965 -1.1399 0 0 0 0 0 0 0 0 0 4.23197 0 0 P54707 AT12A_HUMAN Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) ATP12A ATP1AL1 Homo sapiens (Human) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] AAELLAR;AEFKPGQENVPIMKK;ILEKCSTIMINGEEHPLDK;LYPGSWWDK;TGTLTQNR;VEWEKDYVNDLK;VIMVTGDHPITAK 7 8 0.96442 -1.1711 0 0 12.5532 9.35694 0 0 0 0 0 0 6.61586 0 P54710 ATNG_HUMAN Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain) FXYD2 ATP1C ATP1G1 Homo sapiens (Human) establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376]; transmembrane transport [GO:0055085] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890] ATPase activator activity [GO:0001671]; protein-macromolecule adaptor activity [GO:0030674]; sodium channel regulator activity [GO:0017080] WYLGGSPK 1 12.5 0.92897 -0.48188 0 12.1368 0 0 0 0 0 0 0 0 0 0 P54725 RD23A_HUMAN UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) RAD23A Homo sapiens (Human) nucleotide-excision repair [GO:0006289]; positive regulation of cell cycle [GO:0045787]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991] damaged DNA binding [GO:0003684]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; ubiquitin-specific protease binding [GO:1990381] IRMEPDETVK;TLQQQTFK;VVAALRASYNNPHR 3 8.8 0.97865 -1.9077 0 0 0 0 0 9.28753 0 0 0 0 9.58639 0 P54750 PDE1A_HUMAN "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)" PDE1A Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of smooth muscle cell proliferation [GO:0048660] cytosol [GO:0005829]; neuronal cell body [GO:0043025] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" ELAAQEARTSSQK;SIVHAVQAGIFVERMYRK 2 5.8 0.97517 -1.4417 0 10.3801 0 0 4.73004 0 0 0 0 0 0 0 P54753 EPHB3_HUMAN Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) EPHB3 ETK2 HEK2 TYRO6 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell migration [GO:0016477]; central nervous system projection neuron axonogenesis [GO:0021952]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; digestive tract morphogenesis [GO:0048546]; ephrin receptor signaling pathway [GO:0048013]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of axonogenesis [GO:0050770]; regulation of cell-cell adhesion [GO:0022407]; regulation of GTPase activity [GO:0043087]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; substrate adhesion-dependent cell spreading [GO:0034446]; thymus development [GO:0048538]; urogenital system development [GO:0001655] cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ALEETLMDTK;CHGAGGASACSR;QRHGSDSEYTEK;SFGPLSK 4 4.1 0.93342 -0.51232 0 0 8.20887 0 0 0 0 0 10.6904 0 0 3.56487 P54756 EPHA5_HUMAN Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) EPHA5 BSK EHK1 HEK7 TYRO4 Homo sapiens (Human) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; hippocampus development [GO:0021766]; neuron development [GO:0048666]; positive regulation of CREB transcription factor activity [GO:0032793]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CNSHAGVCEECGGHVR;FDEIVNMLDK;IPIRWTAPEAIAFRK 3 4 0.72795 0.12683 10.5939 0 0 6.59665 0 0 0 8.72434 0 0 0 0 P54760 EPHB4_HUMAN Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) EPHB4 HTK MYK1 TYRO11 Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; heart morphogenesis [GO:0003007]; protein autophosphorylation [GO:0046777] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GIASGMR;IPIRWTAPEAIAFRK 2 2.2 0.81214 0.0020798 0 0 0 10.5361 0 0 0 0 0 0 0 0 P54762 EPHB1_HUMAN Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) EPHB1 ELK EPHT2 HEK6 NET Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; camera-type eye morphogenesis [GO:0048593]; cell chemotaxis [GO:0060326]; cell-substrate adhesion [GO:0031589]; central nervous system projection neuron axonogenesis [GO:0021952]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; hindbrain tangential cell migration [GO:0021934]; immunological synapse formation [GO:0001771]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; optic nerve morphogenesis [GO:0021631]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle satellite cell activation [GO:0014719] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AYSKEAVYSDKLQHYSTGR;LPPPMDCPAALHQLMLDCWQK;TVAGYGK;VQISQSPTAMA 4 5.9 0.95544 -0.81307 0 0 0 0 8.5963 0 0 0 9.02386 0 10.0832 0 P54764 EPHA4_HUMAN Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) EPHA4 HEK8 SEK TYRO1 Homo sapiens (Human) adherens junction organization [GO:0034332]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; cochlea development [GO:0090102]; corticospinal tract morphogenesis [GO:0021957]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; glial cell migration [GO:0008347]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; negative regulation of axon regeneration [GO:0048681]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of translation [GO:0017148]; nephric duct morphogenesis [GO:0072178]; neuron projection fasciculation [GO:0106030]; neuron projection guidance [GO:0097485]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001108]; protein autophosphorylation [GO:0046777]; protein stabilization [GO:0050821]; regulation of astrocyte differentiation [GO:0048710]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of modification of synaptic structure [GO:1905244]; regulation of synapse pruning [GO:1905806]; synapse pruning [GO:0098883] adherens junction [GO:0005912]; axon [GO:0030424]; axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; DH domain binding [GO:0097161]; ephrin receptor binding [GO:0046875]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; kinase activity [GO:0016301]; macrophage colony-stimulating factor receptor activity [GO:0005011]; PH domain binding [GO:0042731]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AKQEADEEKHLNQGVR;DQNERSYR;EGAQRVYIEIK;GIGSGMK;IMKLNTEIR;LIRNPNSLKR;VPGKREICVAIK 7 7.4 0.9752 -4.0463 0 0 10.7352 10.447 14.6286 7.34367 0 10.4551 0 0 0 0 P54802 ANAG_HUMAN Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cerebellar Purkinje cell layer development [GO:0021680]; collagen metabolic process [GO:0032963]; cone retinal bipolar cell differentiation [GO:1904390]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; ganglioside metabolic process [GO:0001573]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin metabolic process [GO:0030202]; hormone metabolic process [GO:0042445]; inner ear receptor cell development [GO:0060119]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; limb development [GO:0060173]; liver development [GO:0001889]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; maintenance of blood-brain barrier [GO:0035633]; microglia differentiation [GO:0014004]; microglial cell activation [GO:0001774]; middle ear morphogenesis [GO:0042474]; mitral valve morphogenesis [GO:0003183]; motor behavior [GO:0061744]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nerve development [GO:0021675]; nervous system development [GO:0007399]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein processing [GO:0016485]; response to disaccharide [GO:0034285]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; rod bipolar cell differentiation [GO:1904389]; sequestering of iron ion [GO:0097577]; superoxide metabolic process [GO:0006801]; toll-like receptor 4 signaling pathway [GO:0034142]; vesicle tethering [GO:0099022] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-N-acetylglucosaminidase activity [GO:0004561] QLAGLVANYYTPRWR;QLYLQHR 2 3 0.95163 -0.69263 0 0 0 0 0 0 0 0 0 0 0 4.54374 P54803 GALC_HUMAN Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase) GALC Homo sapiens (Human) galactosylceramide catabolic process [GO:0006683]; glycosphingolipid catabolic process [GO:0046479]; myelination [GO:0042552] lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] galactosylceramidase activity [GO:0004336] LGKTSERFLFK 1 1.6 0.95831 -1.0108 0 0 0 0 0 12.3676 15.0375 0 0 0 0 0 P54819 KAD2_HUMAN "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]" AK2 ADK2 Homo sapiens (Human) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; sperm mitochondrial sheath [GO:0097226] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524] APSVPAAEPEYPK;AVLLGPPGAGK;MAPSVPAAEPEYPK 3 10.5 0.0089485 1.1575 0 0 0 9.75077 0 0 10.5052 11.0014 10.9004 0 9.52233 0 P54826 GAS1_HUMAN Growth arrest-specific protein 1 (GAS-1) GAS1 Homo sapiens (Human) cell fate commitment [GO:0045165]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; developmental growth [GO:0048589]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein processing [GO:0010955]; regulation of apoptotic process [GO:0042981]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of smoothened signaling pathway [GO:0008589] membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] oxysterol binding [GO:0008142] AIEPCLPR;LAPRGAWTPLASILLLLLGPLF;SSGGGGR;TVIEDMLAMPK 4 13.9 0.95476 -0.93825 0 0 0 0 0 4.17337 0 12.0725 0 0 0 9.67066 P54829 PTN5_HUMAN Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) PTPN5 Homo sapiens (Human) protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LISLKSGTEERGLK 1 2.5 0.76092 0.069559 10.2236 0 0 0 0 0 0 0 0 0 0 0 P54840 GYS2_HUMAN "Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)" GYS2 Homo sapiens (Human) glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749] cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" LSDLLDWR;NRTERLSDLLDWR;TNNFNVETLK 3 3.3 0.94091 -0.59885 0 0 5.62845 0 0 0 0 11.5164 0 0 0 0 P54868 HMCS2_HUMAN "Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)" HMGCS2 Homo sapiens (Human) "acetyl-CoA metabolic process [GO:0006084]; adipose tissue development [GO:0060612]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fatty acid [GO:0071398]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; ketone body biosynthetic process [GO:0046951]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; multicellular organismal response to stress [GO:0033555]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to growth hormone [GO:0060416]; response to linoleic acid [GO:0070543]; response to metal ion [GO:0010038]; response to monosaccharide [GO:0034284]; response to nutrient [GO:0007584]; response to prostaglandin F [GO:0034696]; response to starvation [GO:0042594]; response to temperature stimulus [GO:0009266]; response to testosterone [GO:0033574]; response to triglyceride [GO:0034014]; response to xenobiotic stimulus [GO:0009410]" mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; identical protein binding [GO:0042802] LLTPVKRILQLTR;LMERIQLPWDSVGR 2 5.3 0.93609 -0.53663 0 0 10.8784 0 5.72214 0 0 0 0 0 0 0 P54886 P5CS_HUMAN Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] ALDH18A1 GSAS P5CS PYCS Homo sapiens (Human) citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] EMAIPVLEAR;LSLSTSK 2 2.1 0.94402 -0.62677 0 0 0 8.44004 10.0352 8.02918 0 0 0 0 0 4.63639 P54920 SNAA_HUMAN Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) NAPA SNAPA Homo sapiens (Human) "apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle priming [GO:0016082]" cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044] protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905] IEEACEIYARAANMFK 1 5.4 0.95187 -0.67023 0 0 0 0 0 0 0 0 0 10.099 0 0 P54922 ADPRH_HUMAN ADP-ribosylhydrolase ARH1 (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ([Protein ADP-ribosylarginine] hydrolase) (ADP-ribosylarginine hydrolase) (hARH1) ADPRH ARH1 Homo sapiens (Human) protein de-ADP-ribosylation [GO:0051725]; protein modification process [GO:0036211] extracellular space [GO:0005615] ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955] GLMELLPEAK 1 2.8 0.79442 0.015944 0 0 0 0 0 0 0 0 9.07109 0 0 0 P55001 MFAP2_HUMAN Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1) MFAP2 MAGP1 Homo sapiens (Human) embryonic eye morphogenesis [GO:0048048]; platelet formation [GO:0030220]; positive regulation of cold-induced thermogenesis [GO:0120162]; post-embryonic eye morphogenesis [GO:0048050] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527] fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968] VYVINKEICVR 1 6 0.88235 -0.17974 0 0 0 0 0 0 9.23857 0 9.31947 0 0 0 P55010 IF5_HUMAN Eukaryotic translation initiation factor 5 (eIF-5) EIF5 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synapse [GO:0045202] cadherin binding [GO:0045296]; eukaryotic initiation factor eIF2 binding [GO:0071074]; GDP-dissociation inhibitor activity [GO:0005092]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] RHFLRFCHNNK 1 2.6 0.76699 0.058551 0 0 0 0 8.90887 0 0 0 0 0 0 0 P55011 S12A2_HUMAN Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) SLC12A2 NKCC1 Homo sapiens (Human) ammonium transmembrane transport [GO:0072488]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; inorganic cation import across plasma membrane [GO:0098659]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion transport [GO:0006811]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ammonium channel activity [GO:0008519]; chloride:monoatomic cation symporter activity [GO:0015377]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium ion transmembrane transporter activity [GO:0015079]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; sodium:potassium:chloride symporter activity [GO:0008511] AQIVLLVILLLAIGDFVIGTFIPLESKKPK 1 2.5 0.84173 -0.045328 0 0 3.89093 0 0 0 0 0 0 7.17053 0 0 P55017 S12A3_HUMAN Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) SLC12A3 NCC TSC Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511] LGFHEVHILPDINQNPR;NRVKSLR 2 2.4 0.96527 -1.2437 0 0 0 0 0 0 0 0 0 0 8.31093 9.90008 P55036 PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) PSMD4 MCB1 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723] IIAFVGSPVEDNEK;SPGTAGC 2 7.8 0.53798 0.18498 6.69794 0 1.81316 0 0 0 8.10177 0 8.74705 0 0 0 P55039 DRG2_HUMAN Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-) DRG2 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] GEGFDVMKSGDAR;LVQLILHEYKIFNAEVLFR 2 8.8 0.98116 -1.7105 0 12.5666 0 0 0 0 0 0 0 0 11.2242 0 P55040 GEM_HUMAN GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) GEM KIR Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; signal transduction [GO:0007165] cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233] calcium channel regulator activity [GO:0005246]; calmodulin binding [GO:0005516]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287] QGTVGMQPQQQR;WSIPADGR 2 6.8 0.95452 -0.80048 0 0 0 0 0 0 0 0 9.31002 0 0 9.56428 P55055 NR1H2_HUMAN Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) NR1H2 LXRB NER UNR Homo sapiens (Human) cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; positive regulation of lipid storage [GO:0010884]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of secretion of lysosomal enzymes [GO:0090340]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "apolipoprotein A-I receptor binding [GO:0034191]; ATPase binding [GO:0051117]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ASTIEIMLLETARR 1 3 0.32993 0.24267 0 0 0 0 0 0 0 0 0 10.5245 0 0 P55056 APOC4_HUMAN Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C4) APOC4 Homo sapiens (Human) lipid metabolic process [GO:0006629]; positive regulation of sequestering of triglyceride [GO:0010890]; triglyceride homeostasis [GO:0070328] extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361] lipid transporter activity [GO:0005319] AWFLESK 1 5.5 0.90874 -0.31445 0 0 0 0 0 0 0 8.86756 0 0 0 0 P55058 PLTP_HUMAN Phospholipid transfer protein (Lipid transfer protein II) PLTP Homo sapiens (Human) ceramide transport [GO:0035627]; flagellated sperm motility [GO:0030317]; glycolipid transport [GO:0046836]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; vitamin E biosynthetic process [GO:0010189] extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634] ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; cerebroside transfer activity [GO:0140340]; cholesterol transfer activity [GO:0120020]; diacylglyceride transfer activity [GO:0140337]; diacylglycerol binding [GO:0019992]; high-density lipoprotein particle binding [GO:0008035]; low-density lipoprotein particle binding [GO:0030169]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphatidylglycerol binding [GO:1901611]; phosphatidylglycerol transfer activity [GO:0140339]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid transfer activity [GO:0120014]; sphingomyelin transfer activity [GO:0140338]; very-low-density lipoprotein particle binding [GO:0034189] FLEQELETITIPDLR 1 3 0.57069 0.18163 0 0 11.3175 0 0 0 0 0 0 0 0 0 P55058 PLTP_HUMAN Phospholipid transfer protein (Lipid transfer protein II) PLTP Homo sapiens (Human) ceramide transport [GO:0035627]; flagellated sperm motility [GO:0030317]; glycolipid transport [GO:0046836]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; vitamin E biosynthetic process [GO:0010189] extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634] ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; cerebroside transfer activity [GO:0140340]; cholesterol transfer activity [GO:0120020]; diacylglyceride transfer activity [GO:0140337]; diacylglycerol binding [GO:0019992]; high-density lipoprotein particle binding [GO:0008035]; low-density lipoprotein particle binding [GO:0030169]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transfer activity [GO:1990050]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphatidylglycerol binding [GO:1901611]; phosphatidylglycerol transfer activity [GO:0140339]; phosphatidylinositol transfer activity [GO:0008526]; phospholipid transfer activity [GO:0120014]; sphingomyelin transfer activity [GO:0140338]; very-low-density lipoprotein particle binding [GO:0034189] LQITNASLGLRFR 1 3.2 0.83267 -0.028868 0 0 0 0 0 0 0 0 0 0 5.70614 0 P55060 XPO2_HUMAN Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) CSE1L CAS XPO2 Homo sapiens (Human) protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] DLEGSDIDTR;EHDPVGQMVNNPK;IIIPEIQK;LLQAFLER;QIFILLFQR;QLSDAISIIGREDFPQK;SANVNEFPVLK;TGNIPALVR;TLDPDPAIR;VIVPNMEFR 10 10.6 0 4.7012 18.1497 18.2172 17.9835 15.6328 15.3147 15.016 17.4883 11.4887 10.18 12.1838 12.0758 11.9312 P55061 BI1_HUMAN Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6) TMBIM6 BI1 TEGT Homo sapiens (Human) autophagy [GO:0006914]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of RNA splicing [GO:0033119]; neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0036483]; response to L-glutamate [GO:1902065] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625] KINFDALLK 1 3.8 0.92879 -0.46455 0 0 0 0 0 0 0 0 0 14.0343 14.0415 0 P55072 TERA_HUMAN Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) VCP HEL-220 HEL-S-70 Homo sapiens (Human) "aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral genome replication [GO:0019079]" ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; BAT3 complex binding [GO:1904288]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; deubiquitinase activator activity [GO:0035800]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-modified protein reader activity [GO:0140036]; ubiquitin-specific protease binding [GO:1990381] AFEEAEK;ASGADSKGDDLSTAILK;DVDLEFLAK;EMVELPLRHPALFKAIGVKPPR;FGMTPSK;GDDLSTAILK;GGNIGDGGGAADR;GILLYGPPGTGKTLIAR;LDQLIYIPLPDEK;LIVDEAINEDNSVVSLSQPK;NAPAIIFIDELDAIAPK;REAVCIVLSDDTCSDEKIR;THGEVERR;WALSQSNPSALR 14 22.5 0 22.167 9.57784 11.4128 11.5691 0 0 0 12.4386 10.5746 10.8033 11.6626 10.456 10.5844 P55081 MFAP1_HUMAN Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) MFAP1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" centrosome [GO:0005813]; microfibril [GO:0001527]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] IVEEETK;LKPVFIRKK 2 3.6 0.95137 -0.69366 0 0 0 0 9.15939 0 0 0 0 0 0 5.09761 P55083 MFAP4_HUMAN Microfibril-associated glycoprotein 4 MFAP4 Homo sapiens (Human) cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; regulation of collagen metabolic process [GO:0010712]; supramolecular fiber organization [GO:0097435]; UV protection [GO:0009650] collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] FNGSVSFFRGWNDYK 1 5.9 0.82556 -0.01963 0 6.74551 0 0 0 0 0 7.46508 0 9.50054 0 0 P55084 ECHB_HUMAN "Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]" HADHB MSTP029 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; fatty acid beta-oxidation [GO:0006635]; gene expression [GO:0010467] endoplasmic reticulum [GO:0005783]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; enoyl-CoA hydratase activity [GO:0004300]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723] EAALGAGFSDK;LVMAAANR;NVVVVDGVR;TLVSGWLLYGWIIAVQTK 4 10.2 0.083596 0.39243 0 0 0 8.21636 0 0 0 0 10.8126 0 0 0 P55085 PAR2_HUMAN "Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]" F2RL1 GPR11 PAR2 Homo sapiens (Human) "blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; defense response to virus [GO:0051607]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; leukocyte proliferation [GO:0070661]; mature conventional dendritic cell differentiation [GO:0097029]; negative regulation of chemokine production [GO:0032682]; negative regulation of insulin secretion [GO:0046676]; negative regulation of JNK cascade [GO:0046329]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neutrophil activation [GO:0042119]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070963]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of renin secretion into blood stream [GO:1900135]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; potassium channel activating, G protein-coupled receptor signaling pathway [GO:0099109]; regulation of blood coagulation [GO:0030193]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of JNK cascade [GO:0046328]; T cell activation involved in immune response [GO:0002286]; vasodilation [GO:0042311]" early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057] ANIAIGISLAIWLLILLVTIPLYVVK 1 6.5 0.71055 0.14778 0 0 0 4.91762 0 0 0 0 0 0 0 0 P55087 AQP4_HUMAN Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) AQP4 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; water transport [GO:0006833] astrocyte end-foot [GO:0097450]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] identical protein binding [GO:0042802]; water channel activity [GO:0015250] GVWTQAFWK;MSDRPTAR 2 5.3 0.95122 -0.7059 0 0 0 0 0 0 7.01167 0 0 9.54388 0 0 P55107 GDF10_HUMAN Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP) GDF10 BMP3B Homo sapiens (Human) cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; negative regulation of ossification [GO:0030279]; osteoblast differentiation [GO:0001649]; ovulation cycle [GO:0042698]; positive regulation of osteoblast differentiation [GO:0045669]; response to kainic acid [GO:1904373]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein serine/threonine kinase activator activity [GO:0043539] DISPIVK 1 1.5 0.93682 -0.55386 0 0 0 9.72185 0 0 0 0 0 0 0 0 P55157 MTP_HUMAN Microsomal triglyceride transfer protein large subunit MTTP MTP Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; chylomicron assembly [GO:0034378]; circadian rhythm [GO:0007623]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle remodeling [GO:0034374]; phospholipid transport [GO:0015914]; plasma lipoprotein particle assembly [GO:0034377]; protein secretion [GO:0009306]; response to calcium ion [GO:0051592]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle assembly [GO:0034379] basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; microvillus membrane [GO:0031528]; receptor complex [GO:0043235]; vesicle [GO:0031982] apolipoprotein binding [GO:0034185]; ceramide 1-phosphate transfer activity [GO:1902388]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine transfer activity [GO:1904121]; phospholipid transfer activity [GO:0120014]; phospholipid transporter activity [GO:0005548]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; triglyceride transfer activity [GO:0140344] GHTTGLSLNNDRLYKLTYSTEVLLDR 1 2.9 0.68229 0.16504 0 0 0 0 0 0 0 5.47216 0 0 0 0 P55160 NCKPL_HUMAN Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) NCKAP1L HEM1 Homo sapiens (Human) "actin polymerization-dependent cell motility [GO:0070358]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; cortical actin cytoskeleton organization [GO:0030866]; erythrocyte development [GO:0048821]; erythrocyte homeostasis [GO:0034101]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TORC2 signaling [GO:1904515]; protein-containing complex assembly [GO:0065003]; response to xenobiotic stimulus [GO:0009410]; T cell homeostasis [GO:0043029]" cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; SCAR complex [GO:0031209]; secretory granule membrane [GO:0030667] GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841] EPSLKYINKK;KNRSIVTNMDK;LWKLCLQGSLYITLIR;NSTQHLGPVHREKAEIIR 4 5.1 0.9734 -2.539 0 4.39355 2.27247 0 11.2514 8.9349 0 0 0 13.4357 0 0 P55196 AFAD_HUMAN Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) AFDN AF6 MLLT4 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of cell migration [GO:0030336]; pore complex assembly [GO:0046931]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tight junction [GO:0070160] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267] ARQEEERR;DDREGRFVLK;LQDEERR;SGPGRWK;VTNQLSLS 5 2.2 0.974 -3.0438 9.67133 9.67596 0 0 0 0 11.2261 0 0 0 0 11.7327 P55198 AF17_HUMAN Protein AF-17 (ALL1-fused gene from chromosome 17 protein) MLLT6 AF17 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of urine volume [GO:0035811]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; renal potassium excretion [GO:0036359]; renal sodium excretion [GO:0035812]; renal water absorption [GO:0070295] nucleus [GO:0005634] histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491] EMVGGCCVCSDER;ESKAASGACMTCNRHGCR 2 2.8 0.84954 -0.076313 0 0 0 0 0 0 5.67302 0 0 5.73752 0 0 P55199 ELL_HUMAN RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) ELL C19orf17 Homo sapiens (Human) "in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription elongation by RNA polymerase II [GO:0006368]" Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] cis-regulatory region sequence-specific DNA binding [GO:0000987]; phosphatase binding [GO:0019902] LTDSALRAFESYR;MAALKEDR;RLIAEYDQR 3 4.8 0.95586 -0.98804 8.31302 0 0 0 0 0 0 0 0 9.7724 0 11.7065 P55201 BRPF1_HUMAN Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] acetyltransferase activator activity [GO:0010698]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] KPMDFFTMKQNLEAYR 1 1.3 0.81212 -0.013347 0 0 0 0 0 0 0 0 8.98205 0 0 0 P55209 NP1L1_HUMAN Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) NAP1L1 NRP Homo sapiens (Human) DNA replication [GO:0006260]; nervous system development [GO:0007399]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769] chromatin [GO:0000785]; cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA binding [GO:0003723] IEDEKKDEEK;YAVLYQPLFDK 2 5.4 0.94157 -0.61356 5.6222 0 0 0 0 0 0 0 0 9.03867 0 0 P55210 CASP7_HUMAN Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to staurosporine [GO:0072734]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; heart development [GO:0007507]; lymphocyte apoptotic process [GO:0070227]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411]; striated muscle cell differentiation [GO:0051146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; RNA binding [GO:0003723] HFESQSDDPHFHEK;KQIPCVVSMLTKELYFSQ;VNDRVARHFESQSDDPHFHEK;VTGMGVR 4 15.2 0.93284 -0.50103 0 0 0 0 4.68342 0 0 0 0 0 0 7.1639 P55210 CASP7_HUMAN Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to staurosporine [GO:0072734]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; heart development [GO:0007507]; lymphocyte apoptotic process [GO:0070227]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411]; striated muscle cell differentiation [GO:0051146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; RNA binding [GO:0003723] LTSSSPIPR;VTGMGVR 2 6.3 0.053356 0.47264 11.0943 11.9037 0 0 0 0 11.6218 0 11.0881 0 10.9977 0 P55211 CASP9_HUMAN Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; leukocyte apoptotic process [GO:0071887]; neuron apoptotic process [GO:0051402]; platelet formation [GO:0030220]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; protein processing [GO:0016485]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; signal transduction in response to DNA damage [GO:0042770] apoptosome [GO:0043293]; caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type endopeptidase activity [GO:0004197]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] QAAKLSKPTLENLTPVVLRPEIR 1 5.5 0.88568 -0.19409 0 0 0 0 0 0 0 0 10.9776 0 0 0 P55265 DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; hepatocyte apoptotic process [GO:0097284]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of post-transcriptional gene silencing by regulatory ncRNA [GO:1900369]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; RNA processing [GO:0006396]; somatic diversification of immune receptors via somatic mutation [GO:0002566] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530] adenosine deaminase activity [GO:0004000]; DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251] FLYSELMKYNSQTAK;HYPVFENPKQGKLR;LGERLRTMSCSDK;LTECQLK;QGYSLSGYYTHPFQGYEHR;TMSCSDKILR;VAKQDAAMK;VGGRWFPAVCAHSKK 8 7.7 0.97467 -3.7516 12.9374 0 5.75812 0 0 0 11.9671 11.8558 0 12.605 13.2544 13.2666 P55268 LAMB2_HUMAN Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) LAMB2 LAMS Homo sapiens (Human) astrocyte development [GO:0014002]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; metanephric glomerular basement membrane development [GO:0072274]; metanephric podocyte development [GO:0072249]; neuromuscular junction development [GO:0007528]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; retina development in camera-type eye [GO:0060041]; Schwann cell development [GO:0014044]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; laminin-11 complex [GO:0043260]; laminin-3 complex [GO:0005608]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; synaptic cleft [GO:0043083] extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; structural molecule activity [GO:0005198] AETVQAALEEAQR;HCELCRPFFYR;MELTSRER;SCDCDPMGSQDGGR;TVGDVRRAEQLLQDAR 5 3.4 0.95519 -0.80417 0 0 0 0 7.37417 9.63452 6.542 3.43136 0 0 8.37064 0 P55273 CDN2D_HUMAN Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) CDKN2D Homo sapiens (Human) autophagic cell death [GO:0048102]; DNA synthesis involved in DNA repair [GO:0000731]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of phosphorylation [GO:0042326]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to retinoic acid [GO:0032526]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; sensory perception of sound [GO:0007605] cyclin D2-CDK4 complex [GO:0097129]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901] LLHRELVHPDALNR;LSGAAAR 2 12.7 0.90891 -0.27863 0 0 0 0 5.84398 0 0 0 0 0 9.49937 0 P55283 CADH4_HUMAN Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin) CDH4 Homo sapiens (Human) adherens junction organization [GO:0034332]; axon extension [GO:0048675]; axon guidance [GO:0007411]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon extension [GO:0045773] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] FMQQAVR 1 0.8 0.91281 -0.32188 0 0 0 0 0 7.01848 0 0 0 0 0 0 P55285 CADH6_HUMAN Cadherin-6 (Kidney cadherin) (K-cadherin) CDH6 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; synaptic membrane adhesion [GO:0099560] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DIVPEALFLPR;LHSDQDRGDGSLK;TSGFPAK;VLDVNDNAPEFAEFYETFVCEK 4 6.7 0.96509 -1.1214 0 0 0 8.11192 0 0 0 0 0 0 7.81519 0 P55286 CADH8_HUMAN Cadherin-8 CDH8 Homo sapiens (Human) "adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]; response to cold [GO:0009409]; synaptic transmission, glutamatergic [GO:0035249]" adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] ELSVWHNITIIATEIRNHSQISR 1 2.9 0.83418 -0.029624 0 0 0 0 0 0 0 2.49743 0 0 0 8.14695 P55287 CAD11_HUMAN Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) CDH11 Homo sapiens (Human) adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cell-substrate adhesion [GO:0031589]; corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336]; ossification [GO:0001503]; skeletal system development [GO:0001501] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] FISNGPFK;LLYLGFQLMLFSYVKVNR;SKRGWVWNQFFVIEEYTGPDPVLVGR;VNRRFCLLGVFIK 4 8.9 0.9761 -1.4823 0 4.6828 0 6.54583 5.01645 0 0 0 0 11.7704 0 0 P55316 FOXG1_HUMAN Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3) FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C Homo sapiens (Human) axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; dorsal/ventral pattern formation [GO:0009953]; inner ear morphogenesis [GO:0042472]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" ADGLGGK;GARLTSTGLTFMDR;LDMGDRK 3 5.7 0.9643 -1.1165 0 0 13.2718 0 9.4614 0 0 0 8.89999 0 0 0 P55317 FOXA1_HUMAN Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) FOXA1 HNF3A TCF3A Homo sapiens (Human) alveolar secondary septum development [GO:0061144]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell maturation involved in prostate gland development [GO:0060743]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; glucose homeostasis [GO:0042593]; hormone metabolic process [GO:0042445]; lung epithelial cell differentiation [GO:0060487]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopaminergic neuron differentiation [GO:1904340]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland stromal morphogenesis [GO:0060741]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory basal cell differentiation [GO:1902691]; response to estradiol [GO:0032355]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; smoothened signaling pathway [GO:0007224] chromatin [GO:0000785]; fibrillar center [GO:0001650]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AGGGGDAK;SPDKPGK 2 3.2 0.80978 0.0053402 0 0 0 0 0 0 0 0 0 15.0933 0 0 P55327 TPD52_HUMAN Tumor protein D52 (Protein N8) TPD52 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; positive regulation of cell population proliferation [GO:0008284]; secretion [GO:0046903] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803] ASAAFSSVGSVITK;KLGINSLQELKQNIAK 2 13.4 0.712 0.14812 0 0 8.95936 0 0 0 0 0 0 8.84937 0 0 P55344 LMIP_HUMAN Lens fiber membrane intrinsic protein (MP18) (MP19) (MP20) LIM2 Homo sapiens (Human) cell-cell junction assembly [GO:0007043]; lens development in camera-type eye [GO:0002088] cell junction [GO:0030054]; plasma membrane [GO:0005886]; vesicle [GO:0031982] structural constituent of eye lens [GO:0005212] LSGSFAHQGLWR 1 6.9 0.80823 0.011286 0 0 0 0 0 0 0 5.02848 0 0 0 0 P55347 PKNX1_HUMAN Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) PKNOX1 PREP1 Homo sapiens (Human) angiogenesis [GO:0001525]; camera-type eye development [GO:0043010]; erythrocyte differentiation [GO:0030218]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HPLFPLLALLFEK;NKRGVLPK;QAIYRHPLFPLLALLFEK 3 6 0.87114 -0.10206 0 0 0 0 0 9.13188 0 9.58637 0 0 0 11.539 P55735 SEC13_HUMAN Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) SEC13 D3S1231E SEC13A SEC13L1 SEC13R Homo sapiens (Human) cellular response to nutrient levels [GO:0031669]; COPII-coated vesicle budding [GO:0090114]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] MIHDAQMDYYGTR 1 4.2 0.70906 0.15937 0 0 7.05257 0 0 0 0 0 0 0 0 0 P55769 NH2L1_HUMAN "NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]" SNU13 NHP2L1 Homo sapiens (Human) "maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]; ribosomal small subunit biogenesis [GO:0042274]" box C/D methylation guide snoRNP complex [GO:0031428]; dense fibrillar component [GO:0001651]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; small-subunit processome [GO:0032040]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690] ATPase binding [GO:0051117]; box C/D sno(s)RNA binding [GO:0034512]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] QQIQSIQQSIER;TEADVNPK 2 15.6 0.01222 0.86282 0 0 7.46418 3.33528 0 0 0 0 8.35394 0 9.40856 0 P55786 PSA_HUMAN Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) NPEPPS PSA Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] AGHKATLEEARR;AGIISTVEVLK;ATFDISLVVPKDR;ATLEEAR;DLSLPPVDR;SPVYLTVLK;VALSNMNVIDR;VLGATLLPDLIQK 8 8.5 0.97426 -3.0498 0 0 0 2.62284 10.5597 7.36929 11.0692 0 2.60345 0 0 11.4271 P55789 ALR_HUMAN FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin) GFER ALR HERV1 HPO Homo sapiens (Human) cellular response to actinomycin D [GO:0072717]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; liver development [GO:0001889]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of DNA biosynthetic process [GO:2000573] cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; growth factor activity [GO:0008083]; protein-disulfide reductase activity [GO:0015035] FYPCEECAEDLR;WRDGWKDGSCD 2 11.2 0.97929 -1.5429 9.06708 0 0 0 0 0 0 5.1299 0 0 0 0 P55795 HNRH2_HUMAN "Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]" HNRNPH2 FTP3 HNRPH2 Homo sapiens (Human) regulation of RNA splicing [GO:0043484] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] GAYGGGYGGYDDYGGYNDGYGFGSDR;HTGPNSPDTANDGFVR;STGEAFVQFASQEIAEK 3 13.1 0.71035 0.14778 0 0 0 0 6.07339 0 0 0 0 0 0 0 P55809 SCOT1_HUMAN "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)" OXCT1 OXCT SCOT Homo sapiens (Human) cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260] GLTAVSNNAGVDNFGLGLLLR 1 4 0 7.909 0 0 0 0 0 0 8.51159 8.30993 0 0 0 0 P55854 SUMO3_HUMAN Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) SUMO3 SMT3A SMT3H1 Homo sapiens (Human) negative regulation of DNA binding [GO:0043392]; protein sumoylation [GO:0016925]; regulation of protein localization to nucleus [GO:1900180] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389] SEEKPKEGVK;VAGQDGSVVQFK 2 21.4 0.97773 -1.5014 0 0 0 0 0 0 0 0 0 0 10.3475 0 P55884 EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) EIF3B EIF3S9 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]" molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] DRLSQSKASK;GTQGVVTNFEIFR;VDNAYWLWTFQGR;YMTISDEWDIPEKQPFK 4 6.5 0.97858 -2.1468 9.99237 5.5043 0 0 0 0 0 0 0 0 10.7504 0 P55895 RAG2_HUMAN V(D)J recombination-activating protein 2 (RAG-2) RAG2 Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of T cell differentiation in thymus [GO:0033085]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151] DNA recombinase complex [GO:0097519]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" MICNIISLEDNK;QVVSEGFYFYMLK;VLPLKKPPMKSLR 3 7.2 0.84717 -0.065957 9.89851 11.4907 7.49281 0 0 0 0 0 0 8.68212 0 0 P55899 FCGRN_HUMAN IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) FCGRT FCRN Homo sapiens (Human) IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor [GO:0002416]; immune response [GO:0006955] endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] beta-2-microglobulin binding [GO:0030881]; IgG binding [GO:0019864] ELTFLLFSCPHR 1 3.3 0.88035 -0.15607 0 0 0 8.74096 0 0 0 0 0 0 0 0 P55957 BID_HUMAN BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] BID Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; establishment of protein localization to membrane [GO:0090150]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial outer membrane permeabilization [GO:0097345]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of T cell proliferation [GO:0042129]; release of cytochrome c from mitochondria [GO:0001836]; signal transduction in response to DNA damage [GO:0042770]; supramolecular fiber organization [GO:0097435] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; death receptor binding [GO:0005123]; ubiquitin protein ligase binding [GO:0031625] MDRSIPPGLVNGLALQLR 1 18.2 0.82921 -0.023775 0 0 0 0 0 7.5744 0 0 0 0 0 0 P56180 TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5) TPTE Homo sapiens (Human) protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytosol [GO:0005829]; membrane [GO:0016020] "histone H2AXY142 phosphatase activity [GO:0140793]; monoatomic ion channel activity [GO:0005216]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" FQGVKTPSQK;LIILLRIFHLFHQK;LLRLIILLR;LLRLIILLRIFHLFHQK;NELDNLHK;WTHLLRLLRLIILLR 6 7.4 0.97461 -3.6558 0 0 0 2.79851 2.27852 5.29109 0 4.42183 0 0 8.68654 0 P56182 RRP1_HUMAN Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) RRP1 D21S2056E NNP1 NOP52 RRP1A Homo sapiens (Human) rRNA processing [GO:0006364] "chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723] FYMLMRMVLNESLKVLK;LAGNEQVTR;LFEMASR;LFEMASRQSTPSQNR;LYKVIRK;MVLNESLK;VGAEELTADQNLK 7 13.2 0.96654 -1.2659 0 11.734 12.1746 7.25729 9.63447 5.87698 0 10.904 0 10.0857 0 10.0949 P56192 SYMC_HUMAN "Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)" MARS1 MARS Homo sapiens (Human) cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049] AAETVLK;LENDQIESLR;LENDQIESLRQRFGGGQAK;RALTHIDHSLSR;WWKNPEQVDLYQFMAK 5 6 0.97146 -1.35 0 0 11.7659 9.02744 0 0 0 0 10.8163 0 0 10.3366 P56199 ITA1_HUMAN Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) ITGA1 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; vasodilation [GO:0042311] acrosomal vesicle [GO:0001669]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha1-beta1 complex [GO:0034665]; integrin complex [GO:0008305]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; phosphatase activator activity [GO:0019211]; protein phosphatase binding [GO:0019903] DSCESNHNITCK;IPSGGDGKTLK;NCHMEGK;SIASEPTEK;VTMNFEPNK 5 4.1 0.97322 -2.5088 0 0 13.4755 10.7548 0 0 0 0 12.7831 0 5.74491 11.0341 P56282 DPOE2_HUMAN DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) POLE2 DPE2 Homo sapiens (Human) DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] epsilon DNA polymerase complex [GO:0008622]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] VFYPSNK 1 1.3 0.90948 -0.31529 0 0 0 0 0 0 0 0 0 0 7.57909 0 P56373 P2RX3_HUMAN P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) P2RX3 Homo sapiens (Human) behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; cellular response to ATP [GO:0071318]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; protein homotrimerization [GO:0070207]; regulation of synaptic plasticity [GO:0048167]; response to carbohydrate [GO:0009743]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165]; urinary bladder smooth muscle contraction [GO:0014832] axon [GO:0030424]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; metal ion binding [GO:0046872]; purinergic nucleotide receptor activity [GO:0001614] AWDQCIPKYSFTR;SVVVKSWTIGIINR;VGDVVKFAGQDFAK 3 10.3 0.97417 -1.4216 0 2.4552 0 0 0 0 0 0 0 0 0 8.52293 P56377 AP1S2_HUMAN AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) AP1S2 DC22 Homo sapiens (Human) intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; AP-type membrane coat adaptor complex [GO:0030119]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615] NVLKAIEQADLLQEK 1 7.4 0.91593 -0.43439 0 0 8.26355 0 0 0 0 0 0 0 0 0 P56381 ATP5E_HUMAN "ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon)" ATP5F1E ATP5E Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "hydrolase activity [GO:0016787]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" TEFKANAEK;VAYWRQAGLSYIR 2 43.1 0.9759 -2.3275 0 0 0 0 10.1297 0 0 0 0 0 0 0 P56385 ATP5I_HUMAN "ATP synthase subunit e, mitochondrial (ATPase subunit e) (ATP synthase membrane subunit e) [Cleaved into: ATP synthase subunit e, mitochondrial, N-terminally processed]" ATP5ME ATP5I ATP5K Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] ELAEDDSILK;MVPPVQVSPLIKLGR 2 36.2 0.95505 -0.94467 0 0 11.9169 0 0 0 0 0 0 10.2509 0 0 P56470 LEG4_HUMAN Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) LGALS4 Homo sapiens (Human) antibacterial peptide biosynthetic process [GO:0002780]; cell adhesion [GO:0007155] collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936] VGSSGDIALHINPR 1 4.3 0.8781 -0.13672 0 0 0 0 0 0 0 0 0 0 0 9.79948 P56524 HDAC4_HUMAN Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 KIAA0288 Homo sapiens (Human) "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of glycolytic process [GO:0045820]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of protein binding [GO:0043393]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to interleukin-1 [GO:0070555]; type I interferon-mediated signaling pathway [GO:0060337]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; potassium ion binding [GO:0030955]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]" GKESAVASTEVK;QHREQKLQQLK 2 2.1 0.97348 -2.5501 0 0 12.2387 0 0 8.73023 0 0 0 0 0 0 P56537 IF6_HUMAN Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) EIF6 EIF3A ITGB4BP OK/SW-cl.27 Homo sapiens (Human) assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743] NSLPDTVQIR;TSIEDQDELSSLLQVPLVAGTVNR 2 13.9 0 19.6 10.7499 0 11.0615 0 8.66452 8.07371 0 0 9.22311 0 10.839 8.91001 P56539 CAV3_HUMAN Caveolin-3 (M-caveolin) CAV3 Homo sapiens (Human) actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cardiac muscle cell development [GO:0055013]; cardiac muscle hypertrophy [GO:0003300]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; cytoplasmic microtubule organization [GO:0031122]; detection of muscle stretch [GO:0035995]; endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; glucose homeostasis [GO:0042593]; heart trabecula formation [GO:0060347]; MAPK cascade [GO:0000165]; membrane raft organization [GO:0031579]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cell size [GO:0045792]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900826]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sarcomere organization [GO:0060299]; nucleus localization [GO:0051647]; plasma membrane organization [GO:0007009]; plasma membrane repair [GO:0001778]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization [GO:0008104]; protein localization to plasma membrane [GO:0072659]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of calcium ion import [GO:0090279]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart contraction [GO:0008016]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of nerve growth factor receptor activity [GO:0051394]; regulation of p38MAPK cascade [GO:1900744]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by receptor internalization [GO:0038009]; regulation of skeletal muscle contraction [GO:0014819]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; T-tubule organization [GO:0033292]; triglyceride metabolic process [GO:0006641]; ventricular cardiac muscle cell action potential [GO:0086005] caveola [GO:0005901]; cell surface [GO:0009986]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982]; Z disc [GO:0030018] alpha-tubulin binding [GO:0043014]; calcium channel regulator activity [GO:0005246]; connexin binding [GO:0071253]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; potassium channel inhibitor activity [GO:0019870]; protein-containing complex binding [GO:0044877]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] MAEEHTDLEAQIVK 1 9.3 0.78989 0.016971 0 0 0 7.17503 0 0 0 0 0 0 0 0 P56545 CTBP2_HUMAN C-terminal-binding protein 2 (CtBP2) CTBP2 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872] nucleus [GO:0005634]; synapse [GO:0045202]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]" ESCGIWQLYHFLSRKQEPR;VQSVEQIR 2 5.3 0.84857 -0.076613 0 0 0 0 9.42095 0 0 0 0 0 0 0 P56645 PER3_HUMAN Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) PER3 GIG13 Homo sapiens (Human) "circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]" cytoplasm [GO:0005737]; nucleus [GO:0005634] kinase binding [GO:0019900]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] DITELQEQIYK;TFTSFHQTLK 2 1.7 0.78298 0.03136 0 10.3407 0 0 0 0 8.66541 0 0 0 0 0 P56696 KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4) KCNQ4 Homo sapiens (Human) inner ear morphogenesis [GO:0042472]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; sensory perception of sound [GO:0007605] basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249] SVSTNMD;TVIRSIRILK;VQEQHRQKHFEK 3 4.2 0.90924 -0.27848 0 0 2.6031 0 7.49953 0 0 0 0 0 6.83592 0 P56704 WNT3A_HUMAN Protein Wnt-3a WNT3A Homo sapiens (Human) axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; B cell proliferation [GO:0042100]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell fate commitment [GO:0060923]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; cellular response to retinoic acid [GO:0071300]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; midbrain dopaminergic neuron differentiation [GO:1904948]; modulation of chemical synaptic transmission [GO:0050804]; myoblast differentiation [GO:0045445]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; post-anal tail morphogenesis [GO:0036342]; presynapse assembly [GO:0099054]; protein localization [GO:0008104]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spinal cord association neuron differentiation [GO:0021527]; synaptic vesicle recycling [GO:0036465]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874] cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713] FCRNYVEIMPSVAEGIK;HQGSPGK 2 6.8 0.90629 -0.273 0 5.2566 0 0 0 0 10.7505 0 6.86851 9.38623 9.22867 0 P56705 WNT4_HUMAN Protein Wnt-4 WNT4 UNQ426/PRO864 Homo sapiens (Human) adrenal gland development [GO:0030325]; apoptotic signaling pathway [GO:0097190]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hormone metabolic process [GO:0042445]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; meiotic nuclear division [GO:0140013]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of androgen biosynthetic process [GO:2000180]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; pericyte cell differentiation [GO:1904238]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; Sertoli cell differentiation [GO:0060008]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; transcription corepressor activity [GO:0003714] LVELHTCR;RWNCSTLDSLPVFGK 2 6.6 0.91653 -0.41459 0 0 0 9.42926 0 0 7.35711 0 0 0 0 0 P56706 WNT7B_HUMAN Protein Wnt-7b WNT7B Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; central nervous system vasculogenesis [GO:0022009]; chemoattraction of dopaminergic neuron axon [GO:0036516]; chorio-allantoic fusion [GO:0060710]; developmental growth involved in morphogenesis [GO:0060560]; embryonic organ development [GO:0048568]; embryonic placenta morphogenesis [GO:0060669]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; fibroblast proliferation [GO:0048144]; forebrain regionalization [GO:0021871]; homeostatic process [GO:0042592]; in utero embryonic development [GO:0001701]; inner medullary collecting duct development [GO:0072061]; intracellular oxygen homeostasis [GO:0032364]; lens fiber cell development [GO:0070307]; lobar bronchus development [GO:0060482]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung morphogenesis [GO:0060425]; mammary gland epithelium development [GO:0061180]; metanephric collecting duct development [GO:0072205]; metanephric epithelium development [GO:0072207]; metanephric loop of Henle development [GO:0072236]; metanephros morphogenesis [GO:0003338]; neuron differentiation [GO:0030182]; outer medullary collecting duct development [GO:0072060]; positive regulation of JNK cascade [GO:0046330]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell projection size [GO:0032536]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; response to glucocorticoid [GO:0051384]; stem cell proliferation [GO:0072089]; synapse organization [GO:0050808]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] TSPGADGCDTMCCGR 1 4.3 0.65523 0.16947 0 0 0 5.50513 0 0 0 0 0 0 0 5.55594 P56715 RP1_HUMAN Oxygen-regulated protein 1 (Retinitis pigmentosa 1 protein) (Retinitis pigmentosa RP1 protein) RP1 ORP1 Homo sapiens (Human) "axoneme assembly [GO:0035082]; cellular response to light stimulus [GO:0071482]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction, visible light [GO:0007603]; positive regulation of non-motile cilium assembly [GO:1902857]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]" axoneme [GO:0005930]; ciliary tip [GO:0097542]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] microtubule binding [GO:0008017] EAELDKKHSSLDDFENCSLR;EIGQRDK;GNAKSESR;HRFYRPPTPGLRR;LAACSFSADVSPMER;LYATDGR;MIGQFSYSEERESGENK;SESRKISTHMSSSSR 8 4.5 0.98033 -2.0127 0 8.32908 10.78 0 8.99597 5.30374 0 0 0 9.75761 8.56491 0 P56730 NETR_HUMAN Neurotrypsin (EC 3.4.21.-) (Leydin) (Motopsin) (Serine protease 12) PRSS12 Homo sapiens (Human) exocytosis [GO:0006887]; zymogen activation [GO:0031638] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GPARARTMAYFGEGK;QTPFSGLGLIPIYWSNVRCR 2 4 0.97602 -1.4493 0 0 0 9.94322 0 7.73302 0 0 0 0 0 0 P56817 BACE1_HUMAN Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) BACE1 BACE KIAA1149 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to manganese ion [GO:0071287]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of neuron apoptotic process [GO:0043525]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to lead ion [GO:0010288]; signaling receptor ligand precursor processing [GO:0140448] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle lumen [GO:0070931]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase activity [GO:0004190]; beta-aspartyl-peptidase activity [GO:0008798]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protein serine/threonine kinase binding [GO:0120283] YYQRQLSSTYRDLR 1 2.8 0.57937 0.17998 0 0 10.442 0 0 0 0 0 0 0 0 0 P56856 CLD18_HUMAN Claudin-18 CLDN18 UNQ778/PRO1572 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cellular response to estrogen stimulus [GO:0071391]; digestive tract development [GO:0048565]; epithelial cell proliferation [GO:0050673]; epithelial fluid transport [GO:0042045]; lung alveolus development [GO:0048286]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast development [GO:2001205]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; organ growth [GO:0035265]; protein localization to nucleus [GO:0034504]; response to ethanol [GO:0045471]; tight junction organization [GO:0120193] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] SCVRESSGFTECR 1 5 0.92364 -0.44902 0 0 0 0 5.08954 4.75291 0 0 0 0 0 0 P56915 GSC_HUMAN Homeobox protein goosecoid GSC Homo sapiens (Human) dorsal/ventral neural tube patterning [GO:0021904]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; gastrulation [GO:0007369]; middle ear morphogenesis [GO:0042474]; muscle organ morphogenesis [GO:0048644]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell fate specification [GO:0014036]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" HRTIFTDEQLEALENLFQETK;VEVWFKNR 2 11.3 0.98068 -1.7396 0 0 0 6.52781 0 0 0 0 0 0 0 0 P56945 BCAR1_HUMAN Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) BCAR1 CAS CASS1 CRKAS Homo sapiens (Human) actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell division [GO:0051301]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726] protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] AVPEDAK 1 0.8 0.9108 -0.32063 0 0 10.0896 0 0 0 0 7.26669 0 0 0 0 P56962 STX17_HUMAN Syntaxin-17 STX17 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201] protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] KQKMMEK 1 2.3 0.97835 -1.5306 0 0 0 0 0 0 0 0 0 0 0 12.1877 P57052 RBM11_HUMAN Splicing regulator RBM11 (RNA-binding motif protein 11) RBM11 Homo sapiens (Human) "cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; single-stranded RNA binding [GO:0003727] INSHNYR;TVFVGNLEARVR;VTICKDR 3 9.3 0.97298 -2.5201 9.00054 9.12021 9.86757 0 8.93089 0 0 0 0 0 0 0 P57053 H2BFS_HUMAN Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) H2BC12L H2BFS H2BS1 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AMGIMNSFVNDIFER;EIQTAVR;ESYSVYVYK;HAVSEGTK;IAGEASR;IAGEASRLPHYNK;KESYSVYVYK;LLLPGELAK;QVHPDTGISSK 9 57.9 0.94093 -0.60828 0 0 0 0 0 0 0 0 0 0 12.0959 0 P57054 PIGP_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P) PIGP DCRC DSCR5 DSCRC NPD010 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176] KYQEEAIPALR 1 7 0.91668 -0.35573 0 0 0 0 0 10.1037 0 0 0 0 0 0 P57055 DSCR6_HUMAN Protein ripply3 (Down syndrome critical region protein 6) RIPPLY3 DSCR6 Homo sapiens (Human) cell population proliferation [GO:0008283]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharyngeal system development [GO:0060037] nucleus [GO:0005634] EPEAAAGAR 1 4.7 0.93706 -0.56367 10.5982 0 0 0 0 0 0 0 0 0 0 0 P57058 HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V) HUNK MAKV Homo sapiens (Human) intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GDFLHRPFSKK;LYQIEKYRAPK 2 3.1 0.60743 0.17605 0 10.1144 0 10.5248 0 0 0 0 0 0 0 0 P57059 SIK1_HUMAN Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) SIK1 SIK SNF1LK Homo sapiens (Human) anoikis [GO:0043276]; cardiac muscle cell differentiation [GO:0055007]; entrainment of circadian clock by photoperiod [GO:0043153]; intracellular signal transduction [GO:0035556]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of anoikis [GO:2000210]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of mitotic cell cycle [GO:0007346]; regulation of myotube differentiation [GO:0010830]; regulation of sodium ion transport [GO:0002028]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP response element binding protein binding [GO:0008140]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone deacetylase binding [GO:0042826]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LDSSNLEKIYR 1 1.4 0.88583 -0.18084 0 0 0 0 0 0 11.7633 0 0 0 0 0 P57060 RWD2B_HUMAN RWD domain-containing protein 2B RWDD2B C21orf6 GL011 Homo sapiens (Human) LWIYSHHIYNK;NILEWAK 2 5.6 0.96598 -1.1261 0 0 0 0 0 0 0 0 0 0 0 10.112 P57071 PRD15_HUMAN PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298) PRDM15 C21orf83 ZNF298 Homo sapiens (Human) methylation [GO:0032259]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DIALMDDHQR;EYECKECHR;KDMLKEHMR;KYVTEYMLQKHVQLTHDK;MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVK;SLILSSRHGIR;TFQCEMCFR;VEAQSCQLCGTKVSTR;WEKESAFPLKVFQK 9 11.5 0.96538 -1.2112 8.17473 5.61492 9.75792 0 0 10.6143 0 3.81793 10.7526 6.60404 0 10.5944 P57075 UBS3A_HUMAN Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) UBASH3A STS2 Homo sapiens (Human) negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of cytokine production [GO:0001817] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] KDGEASSR 1 1.2 0.92901 -0.47035 0 0 0 0 0 0 0 0 0 0 0 9.57465 P57076 CF298_HUMAN Cilia- and flagella-associated protein 298 (Protein kurly homolog) CFAP298 C21orf48 C21orf59 Homo sapiens (Human) cilium assembly [GO:0060271]; regulation of cilium movement [GO:0003352] cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] LSDYVGK 1 2.4 0.90982 -0.3101 0 0 0 0 0 0 0 0 9.51479 0 0 10.3736 P57078 RIPK4_HUMAN Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) RIPK4 ANKRD3 DIK Homo sapiens (Human) morphogenesis of an epithelium [GO:0002009]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; skin development [GO:0043588] cytoplasm [GO:0005737]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] MELLEEAKKMEMAK;VGSGGFGQVYKVRHVHWK;WLLLNNANPNLSNRR 3 5.6 0.9766 -2.1794 0 11.6956 0 0 0 0 0 0 10.1747 0 13.3731 0 P57081 WDR4_HUMAN tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) WDR4 Homo sapiens (Human) DNA damage response [GO:0006974]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA modification [GO:0006400] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527] enzyme activator activity [GO:0008047]; tRNA methyltransferase activator activity [GO:0141106] ATFDNVTSYLK 1 2.7 0.89654 -0.23458 0 0 0 0 0 0 0 0 0 7.60615 0 0 P57087 JAM2_HUMAN Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) JAM2 C21orf43 VEJAM UNQ219/PRO245 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cellular extravasation [GO:0045123]; hematopoietic stem cell migration to bone marrow [GO:0097241]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; lymphocyte aggregation [GO:0071593]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of myelination [GO:0031642]; positive regulation of lymphocyte migration [GO:2000403]; spermatid development [GO:0007286] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; somatodendritic compartment [GO:0036477]; tight junction [GO:0070160] integrin binding [GO:0005178] CQDKEGNPAPEYTWFK;DQQVVTAVEYQGDFKNR;KGYFSKETSFQK;SRHRLLLLLLR 4 21.4 0.82555 -0.020316 0 0 0 0 0 0 3.51576 0 0 0 7.61006 0 P57087 JAM2_HUMAN Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) JAM2 C21orf43 VEJAM UNQ219/PRO245 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cellular extravasation [GO:0045123]; hematopoietic stem cell migration to bone marrow [GO:0097241]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; lymphocyte aggregation [GO:0071593]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of myelination [GO:0031642]; positive regulation of lymphocyte migration [GO:2000403]; spermatid development [GO:0007286] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; somatodendritic compartment [GO:0036477]; tight junction [GO:0070160] integrin binding [GO:0005178] AAAGGSR;CQDKEGNPAPEYTWFK;KGYFSKETSFQK;SRHRLLLLLLR;TVSSRLEWK 5 17.6 0.98079 -1.7307 0 10.5643 0 0 8.06404 0 0 11.4367 6.15105 10.8369 0 0 P57088 TMM33_HUMAN Transmembrane protein 33 (Protein DB83) (SHINC-3) TMEM33 DB83 Homo sapiens (Human) endoplasmic reticulum tubular network organization [GO:0071786]; innate immune response [GO:0045087]; membrane organization [GO:0061024]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; nuclear envelope [GO:0005635] ALLANALTSALR;GSNSLPLLR;NPYCRTLFNELR 3 13.4 0.91689 -0.42632 11.238 0 0 0 0 9.30567 0 0 0 6.60859 0 0 P57103 NAC3_HUMAN Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; myelination [GO:0042552]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808] anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] KGGDMSK;MMTGAGNILK;TVEGTAK;VIDDEAYEKNK 4 3.8 0.66667 0.16853 0 10.4726 0 9.32064 0 0 0 0 0 12.9808 0 12.5753 P57678 GEMI4_HUMAN Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) GEMIN4 Homo sapiens (Human) rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] ribonucleoprotein complex binding [GO:0043021] LDVEEVDLSLRIFIQTLEANACR;TSLSKEDR 2 2.9 0.97505 -1.3841 5.67155 0 0 0 0 0 0 0 0 0 0 0 P57679 EVC_HUMAN EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) EVC Homo sapiens (Human) cartilage development [GO:0051216]; endochondral bone growth [GO:0003416]; muscle organ development [GO:0007517]; positive regulation of smoothened signaling pathway [GO:0045880]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224] ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; plasma membrane protein complex [GO:0098797] DLLHLDTALR;NLESNAQTPSETGSPSRRR 2 2.9 0.84039 -0.046318 0 0 0 0 0 6.91695 0 9.274 0 0 0 0 P57682 KLF3_HUMAN Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) KLF3 BKLF Homo sapiens (Human) cellular response to peptide [GO:1901653]; hemopoiesis [GO:0030097]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CDYDGCNK;SSPPSAGNSPSSLK 2 6.4 0.9153 -0.36757 0 0 0 0 0 0 0 0 0 4.81859 9.49205 0 P57723 PCBP4_HUMAN Poly(rC)-binding protein 4 (Alpha-CP4) PCBP4 Homo sapiens (Human) "negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase II [GO:0006357]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] AGTKIKEIR;MAAANGSKKAER 2 5.2 0.96451 -1.2312 0 8.60466 0 10.2265 0 10.5144 0 0 0 0 0 0 P57727 TMPS3_HUMAN Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein) TMPRSS3 ECHOS1 TADG12 UNQ323/PRO382 Homo sapiens (Human) intracellular sodium ion homeostasis [GO:0006883]; proteolysis [GO:0006508]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025] serine-type endopeptidase activity [GO:0004252]; sodium channel regulator activity [GO:0017080] MCSDDWK;VTALHHSVYVR 2 5.5 0.91034 -0.31972 0 0 0 3.0985 0 0 0 0 5.12122 0 0 0 P57727 TMPS3_HUMAN Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein) TMPRSS3 ECHOS1 TADG12 UNQ323/PRO382 Homo sapiens (Human) intracellular sodium ion homeostasis [GO:0006883]; proteolysis [GO:0006508]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025] serine-type endopeptidase activity [GO:0004252]; sodium channel regulator activity [GO:0017080] LLCWRKPTKMK;VTALHHSVYVR 2 7.5 0.93239 -0.49411 0 0 0 0 5.36156 0 0 12.7308 0 0 0 7.01937 P57729 RAB38_HUMAN Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1) RAB38 Homo sapiens (Human) endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome acidification [GO:0090383]; platelet dense granule organization [GO:0060155]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of protein localization to cell periphery [GO:1904377]; protein localization to membrane [GO:0072657]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cell body [GO:0044297]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924] ATIGVDFALKVLHWDPETVVR 1 10 0.92154 -0.43896 0 0 0 0 0 0 0 0 0 9.65283 0 0 P57737 CORO7_HUMAN Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) CORO7 Homo sapiens (Human) actin filament polymerization [GO:0030041]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; positive regulation of hippo signaling [GO:0035332]; protein transport [GO:0015031] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] actin binding [GO:0003779] KEELLNAMVAK 1 1.2 0.91557 -0.34029 0 0 0 0 0 0 0 0 0 0 0 10.3657 P57740 NU107_HUMAN Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) NUP107 Homo sapiens (Human) female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] EADLDVATITK;IDVIDWLVFDPAQR;LLASLYRDRIQSALEEESVFAVTAVNASEK 3 5.9 0.96597 -1.1306 0 0 0 0 11.6149 11.2235 0 10.3095 0 0 11.317 8.29912 P57764 GSDMD_HUMAN "Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]" GSDMD DFNA5L GSDMDC1 FKSG10 Homo sapiens (Human) defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; pore complex assembly [GO:0046931]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; protein secretion [GO:0009306]; pyroptotic cell death [GO:0141201]; pyroptotic inflammatory response [GO:0070269] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]" AEVETISK;EGSGRFSLPGATCLQGEGQGHLSQK;MGSAFER 3 8.3 0.97562 -1.4333 0 0 0 0 10.4928 0 0 0 0 0 0 7.81429 P57771 RGS8_HUMAN Regulator of G-protein signaling 8 (RGS8) RGS8 Homo sapiens (Human) G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of dopamine receptor signaling pathway [GO:0060159] cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] DPQAMRTGQRQNK;SKMYLDLLSQSQR;SLSDHPVGK;TGQRQNK 4 17.7 0.97787 -2.1588 0 0 9.83047 0 0 6.1675 0 7.97166 0 0 0 0 P57772 SELB_HUMAN "Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)" EEFSEC SELB Homo sapiens (Human) selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049] YVFDTHKR 1 1.3 0.84013 -0.043952 0 0 0 8.58868 8.1984 8.5218 0 0 0 0 0 0 P57773 CXA9_HUMAN Gap junction alpha-9 protein (Connexin-58) (Cx58) (Connexin-59) (Cx59) (Gap junction alpha-10 protein) GJA9 GJA10 Homo sapiens (Human) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] IYDSKHPPQLLQSTVSTFSGR;VPGSKATASSLLLILQRPTSSQPRLK 2 9.1 0.87627 -0.12479 0 0 0 0 4.8514 0 0 0 0 0 9.58853 0 P57775 FBXW4_HUMAN F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4) FBXW4 FBW4 SHFM3 Homo sapiens (Human) embryonic limb morphogenesis [GO:0030326]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ALGRLAQVCR;LGTDLMTSVPVK 2 5.3 0.96481 -1.2286 0 0 0 0 0 0 0 8.98197 9.12311 0 12.5233 0 P57789 KCNKA_HUMAN Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit) KCNK10 TREK2 Homo sapiens (Human) cellular response to arachidonate [GO:1904551]; memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; signal transduction [GO:0007165] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] mechanosensitive potassium channel activity [GO:0098782]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841] AHAAEWK;IYKTFRNYSLDEEK;TLPEDVQK 3 5.4 0.96237 -1.0688 0 9.02569 0 0 0 0 0 0 0 0 0 4.27083 P57796 CABP4_HUMAN Calcium-binding protein 4 (CaBP4) CABP4 Homo sapiens (Human) photoreceptor cell morphogenesis [GO:0008594]; phototransduction [GO:0007602]; retinal bipolar neuron differentiation [GO:0060040]; retinal cone cell development [GO:0046549]; signal transduction [GO:0007165]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; synapse [GO:0045202]; terminal bouton [GO:0043195] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325] IAFREFDR 1 2.9 0.91338 -0.33804 0 0 0 0 0 0 0 0 8.46021 0 0 0 P58004 SESN2_HUMAN Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) SESN2 Hi95 SEST2 Homo sapiens (Human) "cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; D-glucose import [GO:0046323]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; fatty acid beta-oxidation [GO:0006635]; glucose homeostasis [GO:0042593]; mitochondrial DNA metabolic process [GO:0032042]; negative regulation of cell growth [GO:0030308]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; positive regulation of lipophagy [GO:1904504]; positive regulation of macroautophagy [GO:0016239]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of TORC1 signaling [GO:1904263]; reactive oxygen species metabolic process [GO:0072593]; regulation of gluconeogenesis [GO:0006111]; regulation of protein phosphorylation [GO:0001932]; regulation of response to reactive oxygen species [GO:1901031]; regulation of TORC1 signaling [GO:1903432]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; triglyceride homeostasis [GO:0070328]" Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; TORC2 complex [GO:0031932] "GDP-dissociation inhibitor activity [GO:0005092]; L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; PH domain binding [GO:0042731]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; sulfiredoxin activity [GO:0032542]" FAPGGVGDSGPGEEQR 1 3.3 0.7855 0.029217 0 6.64933 0 0 0 0 0 0 0 0 0 0 P58005 SESN3_HUMAN Sestrin-3 (EC 1.11.1.-) SESN3 SEST3 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glucose homeostasis [GO:0042593]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of response to reactive oxygen species [GO:1901031]; response to insulin [GO:0032868]; TORC2 signaling [GO:0038203] cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC2 complex [GO:0031932] "L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]" LYSDIGHLLDEK 1 2.4 0.80467 0.013059 0 0 0 0 0 0 0 0 0 9.29692 11.7934 0 P58107 EPIPL_HUMAN Epiplakin (450 kDa epidermal antigen) EPPK1 EPIPL Homo sapiens (Human) intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; regulation of epithelium regeneration [GO:1905041]; wound healing [GO:0042060] apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; membrane [GO:0016020]; perinucleolar compartment [GO:0097356] intermediate filament binding [GO:0019215]; keratin filament binding [GO:1990254]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] AAAGYPDPYSR;DIYALISDQKHMR;GLIVREHGIR;GLLRPGTALILLEAQAATGFIIDPK;GYFDEEMNR;LAAVDVSAR;QEKMSIYQAMWK;TTVPQLLASVQRWVQETKLLAQAR;VIEETEER;VLADPSDDTK;VPVDVAYQR;VPVDVAYR;VPVSTGR 13 7.6 0.97311 -2.9426 0 8.8524 0 0 4.88474 3.60798 9.04936 12.2895 11.0443 0 0 11.0393 P58166 INHBE_HUMAN Inhibin beta E chain (Activin beta-E chain) INHBE Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179] LAPQAER;TPTCEPATPLCCR 2 5.7 0.9075 -0.30694 10.9349 9.42305 0 0 0 0 0 0 0 0 0 0 P58173 OR2B6_HUMAN Olfactory receptor 2B6 (Hs6M1-32) (Olfactory receptor 2B1) (Olfactory receptor 2B5) (Olfactory receptor 5-40) (OR5-40) (Olfactory receptor 6-31) (OR6-31) (Olfactory receptor OR6-4) OR2B6 OR2B1 OR2B1P OR2B5 OR2B6P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DQGKMVSLFYGIIAPMLNPLIYTLR;LVARVFLIK;LVARVFLIKK;RLVARVFLIK 4 11.5 0.3909 0.2137 0 0 1.35693 0 0 0 0 0 0 7.45771 4.80137 2.47171 P58181 O10A3_HUMAN Olfactory receptor 10A3 (HTPCRX12) (Olfactory receptor OR11-97) OR10A3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RKVILHTF 1 2.5 0.97767 -1.5134 0 0 0 0 0 0 0 0 0 0 0 8.0781 P58304 VSX2_HUMAN Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) VSX2 CHX10 HOX10 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" KPEGERQALPKLDK;SALNQTKKR 2 6.4 0.95677 -1.0237 0 0 6.32539 0 0 6.39307 0 0 0 0 0 0 P58335 ANTR2_HUMAN Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2) ANTXR2 CMG2 Homo sapiens (Human) cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] EEEEEPLPTKKWPTVDASYYGGR;GFMLGSR;GGFQALK;GVGGIKRMEVR;LDGLVPSYAEKEAK 5 12.7 0.96447 -1.1746 0 10.4642 0 0 0 0 0 0 10.2661 9.81964 0 0 P58340 MLF1_HUMAN Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) MLF1 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; myeloid progenitor cell differentiation [GO:0002318]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355]; regulation of signal transduction by p53 class mediator [GO:1901796] ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] DNA binding [GO:0003677]; protein domain specific binding [GO:0019904] IGDEPPK;SETLMYIK 2 5 0.95545 -0.87276 0 0 0 0 0 6.42532 0 0 11.4818 0 0 0 P58397 ATS12_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) ADAMTS12 UNQ1918/PRO4389 Homo sapiens (Human) cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of cellular response to hepatocyte growth factor stimulus [GO:2001113]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of hepatocyte growth factor receptor signaling pathway [GO:1902203]; ossification involved in bone maturation [GO:0043931]; proteoglycan catabolic process [GO:0030167]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of inflammatory response [GO:0050727] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DLDGSEDWVYYR;EPTCGLK;GTISNGK;NHDEPCDVTR;RDLDGSEDWVYYR;TLLSCNR;VDASGHFLSYGLHYPITSSRR 7 4.1 0.91701 -0.4292 12.8274 11.6995 11.5101 11.4777 0 0 5.839 0 4.14902 5.69404 0 11.6957 P58417 NXPH1_HUMAN Neurexophilin-1 NXPH1 NPH1 Nbla00697 Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] ENDTDLDLR;IEYEKVDKATK 2 7.4 0.94141 -0.60608 0 0 0 0 0 0 0 0 0 6.78869 0 0 P58512 CU067_HUMAN Uncharacterized protein encoded by LINC01547 LINC01547 C21orf67 C21orf69 Homo sapiens (Human) endoplasmic reticulum [GO:0005783] INPPPWAPACLPGFPVSWRTR 1 9.6 0.82565 -0.019455 0 0 0 0 0 0 0 10.0434 0 0 0 0 P58513 CU042_HUMAN Putative uncharacterized protein encoded by LINC00158 LINC00158 C21orf42 NCRNA00158 Homo sapiens (Human) IQSHFGTLPR 1 12.3 0.84674 -0.064111 0 0 0 9.06983 0 0 0 0 0 0 0 0 P58546 MTPN_HUMAN Myotrophin (Protein V-1) MTPN Homo sapiens (Human) catecholamine metabolic process [GO:0006584]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell differentiation [GO:0021707]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of macromolecule biosynthetic process [GO:0010557]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein metabolic process [GO:0051247]; regulation of barbed-end actin filament capping [GO:2000812]; regulation of cell size [GO:0008361]; regulation of striated muscle tissue development [GO:0016202]; regulation of translation [GO:0006417]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle cell differentiation [GO:0051146] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] sequence-specific DNA binding [GO:0043565] DYVAKGEDVNRTLEGGR;GPDGLTAFEATDNQAIK 2 28.8 0.024254 0.59889 0 0 0 0 8.1642 0 0 0 0 9.2685 9.17891 0 P58557 YBEY_HUMAN Endoribonuclease YbeY (EC 3.1.-.-) YBEY C21orf57 Homo sapiens (Human) rRNA processing [GO:0006364] mitochondrion [GO:0005739]; nucleus [GO:0005634] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; RNA endonuclease activity [GO:0004521] EKAVLDELGRR 1 13.9 0.74403 0.088937 0 0 0 8.56917 0 0 10.4338 0 10.5848 9.57684 0 0 P58658 EVA1C_HUMAN Protein eva-1 homolog C (Protein FAM176C) (SUE21) EVA1C C21orf63 C21orf64 FAM176C PRED34 UNQ2504/PRO5993 Homo sapiens (Human) membrane [GO:0016020] carbohydrate binding [GO:0030246]; heparin binding [GO:0008201] ESCAKDFR 1 1.8 0.91443 -0.33804 0 0 0 0 0 0 0 0 0 5.93022 0 0 P59036 CU082_HUMAN Putative uncharacterized protein encoded by LINC00310 LINC00310 C21orf82 NCRNA00310 Homo sapiens (Human) FRGSSQK 1 10.9 0.98022 -1.6004 0 0 0 0 0 0 0 0 0 0 9.44454 0 P59044 NLRP6_HUMAN "NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5)" NLRP6 NALP6 PYPAF5 Homo sapiens (Human) acute inflammatory response [GO:0002526]; acute inflammatory response to antigenic stimulus [GO:0002438]; antiviral innate immune response [GO:0140374]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of type II interferon production [GO:0032689]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; NLRP6 inflammasome complex assembly [GO:0140739]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of mucus secretion [GO:0070255]; wound healing [GO:0042060] canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP6 inflammasome complex [GO:0140738]; non-membrane-bounded organelle [GO:0043228]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptide binding [GO:0042277]; signaling adaptor activity [GO:0035591]; vasopressin receptor activity [GO:0005000] GLQYLVGMLR;LSEAGLR;LVAAQEK 3 2.7 0.95221 -0.72157 0 0 0 0 9.74551 0 10.1325 0 0 0 0 12.9093 P59045 NAL11_HUMAN "NACHT, LRR and PYD domains-containing protein 11 (Nucleotide-binding oligomerization domain protein 17) (PAAD-and NACHT domain-containing protein 10) (PYRIN-containing APAF1-like protein 6)" NLRP11 NALP11 NOD17 PAN10 PYPAF6 Homo sapiens (Human) regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] "ATP binding [GO:0005524]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]; RNA binding [GO:0003723]" IFQNKEPLIRPTAR;VAILCWITCTVLKR;VAILCWITCTVLKRQMDK;VPIPVLLVSLLK;VPIPVLLVSLLKR;VPIPVLLVSLLKRK 6 4.7 0.89538 -0.22768 0 5.22655 5.80833 0 4.93348 0 9.39577 4.82018 0 4.99168 9.26235 0 P59046 NAL12_HUMAN "NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)" NLRP12 NALP12 PYPAF7 RNO Homo sapiens (Human) cellular response to cytokine stimulus [GO:0071345]; dendritic cell migration [GO:0036336]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of signal transduction [GO:0009968]; negative regulation of Toll signaling pathway [GO:0045751]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-18 production [GO:0032661]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; protein-macromolecule adaptor activity [GO:0030674] ILFEEQDLR;LLWLFGMDLNK 2 2 0.91115 -0.28621 0 13.109 0 0 0 0 0 0 0 0 0 0 P59047 NALP5_HUMAN "NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require)" NLRP5 MATER NALP5 Homo sapiens (Human) actin filament organization [GO:0007015]; cortical granule exocytosis [GO:0060471]; establishment of organelle localization [GO:0051656]; establishment of spindle localization [GO:0051293]; exocytosis [GO:0006887]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]; regulation of inflammatory response [GO:0050727]; regulation of protein localization [GO:0032880] cell cortex [GO:0005938]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; subcortical maternal complex [GO:0106333] ATP binding [GO:0005524]; tubulin binding [GO:0015631] ALVTLSTGPTCSILPK;AMKTLCAKLR;GIGEHQK;QAGFHIHSLWMKRFLFGLVSEDVR;QLDLGSSILTER 5 5.8 0.98124 -1.7556 0 10.1267 0 0 0 0 0 0 0 6.33127 7.44153 0 P59095 STAR6_HUMAN StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6) STARD6 Homo sapiens (Human) lipid transport [GO:0006869] lipid binding [GO:0008289] LSPSIIEK;LVMFVQTEMRGK 2 9.1 0.94589 -0.65137 0 11.8972 0 9.60696 0 0 0 0 0 0 0 0 P59190 RAB15_HUMAN Ras-related protein Rab-15 RAB15 Homo sapiens (Human) exocytosis [GO:0006887]; positive regulation of regulated secretory pathway [GO:1903307]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482] cilium [GO:0005929]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LLLIGDSGVGK;LTELVLQAHR 2 9.9 0.94102 -0.58841 11.8426 0 0 0 0 0 0 0 0 0 0 0 P59510 ATS20_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) ADAMTS20 Homo sapiens (Human) apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967]; proteolysis [GO:0006508]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DPSIGNLIHIVVVKLVMIHR;DVYCRLK;SRESYCMNNFGHR;SVRCPSWK;TCGGGIESATRR;VLGHTSK;WLPRYSGIGTKDR;WLTGLLYHLSLFITRSWEVDFHPRQEALVR;WLTQGSYTSVSIRRSEDGTR;YIEIMVTADAK 10 7.4 0.976 -5.1804 11.1198 0 7.9151 7.54651 0 9.24966 0 9.622 0 0 9.20031 9.57327 P59534 T2R39_HUMAN Taste receptor type 2 member 39 (T2R39) (Taste receptor type 2 member 57) (T2R57) TAS2R39 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] ILVFLSVSR;LGRCFPPDTK 2 5.6 0.97877 -1.919 0 0 0 0 0 0 8.78953 10.1774 0 0 0 0 P59538 T2R31_HUMAN Taste receptor type 2 member 31 (T2R31) (Taste receptor type 2 member 44) (T2R44) (Taste receptor type 2 member 53) (T2R53) TAS2R31 TAS2R44 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] GEKPSSP 1 2.3 0.90917 -0.31466 0 0 0 0 0 0 4.61712 0 0 0 0 0 P59539 T2R45_HUMAN Taste receptor type 2 member 45 (T2R45) (G-protein coupled receptor 59) TAS2R45 GPR59 Homo sapiens (Human) sensory perception of taste [GO:0050909] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] KLKQTYLSVLWQMR 1 4.7 0.86863 -0.09073 0 0 0 0 0 0 0 0 0 3.1495 0 0 P59543 T2R20_HUMAN Taste receptor type 2 member 20 (Taste receptor type 2 member 49) (T2R49) (Taste receptor type 2 member 56) (T2R56) TAS2R20 TAS2R49 Homo sapiens (Human) membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] TLKQTFLSVLWQVTCWAK 1 5.8 0.81837 -0.017414 0 8.54346 0 0 0 0 0 0 0 0 0 0 P59551 T2R60_HUMAN Taste receptor type 2 member 60 (T2R60) (Taste receptor type 2 member 56) (T2R56) TAS2R60 Homo sapiens (Human) sensory perception of bitter taste [GO:0050913] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AIILVTILLLLR 1 3.8 0.89495 -0.24343 0 0 0 0 0 0 0 9.87718 0 0 0 0 P59666 DEF3_HUMAN "Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]" DEFA3 DEF3 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; disruption of plasma membrane integrity in another organism [GO:0051673]; estrogen receptor signaling pathway [GO:0030520]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] protein homodimerization activity [GO:0042803] NMDCYCR 1 7.4 0.9136 -0.32909 0 0 0 0 0 0 0 0 0 0 5.59225 0 P59773 MNARL_HUMAN Major intrinsically disordered NOTCH2-binding receptor 1-like (Major intrinsically disordered NOTCH2-associated receptor 2) (Membrane integral NOTCH2-associated receptor 2) MINAR2 KIAA1024L Homo sapiens (Human) angiogenesis [GO:0001525]; cholesterol homeostasis [GO:0042632]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; neuron apoptotic process [GO:0051402]; sensory perception of sound [GO:0007605]; walking behavior [GO:0090659] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; stereocilium [GO:0032420] cholesterol binding [GO:0015485] NNPLYGDLSLEEAMEERK 1 9.5 0.87016 -0.091099 0 0 0 9.27845 0 0 0 0 0 0 0 0 P59780 AP3S2_HUMAN AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) AP3S2 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; synaptic vesicle [GO:0008021] LVRFYQRFPEEIQQQIVR;NINIGDLNIKVPNLSQFV 2 18.7 0.50537 0.18782 0 0 11.7846 0 0 0 0 0 0 0 0 0 P59817 Z280A_HUMAN Zinc finger protein 280A (3'OY11.1) (Suppressor of hairy wing homolog 1) (Zinc finger protein 636) ZNF280A SUHW1 ZNF280 ZNF636 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NIKFMNHMK 1 1.7 0.90284 -0.26498 0 0 0 8.65141 0 0 0 0 0 0 0 0 P59826 BPIB3_HUMAN "BPI fold-containing family B member 3 (Ligand-binding protein RYA3) (Long palate, lung and nasal epithelium carcinoma-associated protein 3)" BPIFB3 C20orf185 LPLUNC3 Homo sapiens (Human) innate immune response [GO:0045087] cytoplasm [GO:0005737]; extracellular region [GO:0005576] lipid binding [GO:0008289] LPLHQQLLLFLRVR;VALAVSSRGTPILILKR 2 6.6 0.91315 -0.38311 0 0 0 3.33371 0 0 5.54603 0 5.27903 0 0 0 P59827 BPIB4_HUMAN "BPI fold-containing family B member 4 (Ligand-binding protein RY2G5) (Long palate, lung and nasal epithelium carcinoma-associated protein 4)" BPIFB4 C20orf186 LPLUNC4 Homo sapiens (Human) actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular region [GO:0005576] lipid binding [GO:0008289] IQVLNPPSVMLQKDKALVK;IVELTLPRVSVRLLPGVGVYLSLYTR;LLRGLLPNLVDNLVNR;VFQQYPESCPLIIRIQVLNPPSVMLQKDK;VKLLRGLLPNLVDNLVNR;VSVRLLPGVGVYLSLYTR 6 12.5 0.98062 -1.6085 0 7.61265 7.47808 8.85543 4.44645 0 0 0 11.9521 6.61198 0 0 P59901 LIRA4_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g) LILRA4 ILT7 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; Fc-epsilon receptor signaling pathway [GO:0038095]; immune response-regulating signaling pathway [GO:0002764]; innate immune response [GO:0045087]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of toll-like receptor 7 signaling pathway [GO:0034156]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; negative regulation of tumor necrosis factor production [GO:0032720] Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor binding [GO:0005102] EGADGLPQRPGR;LSWTLNSHQHNHGK 2 5.2 0.94455 -0.63976 12.0479 0 0 0 0 0 0 0 0 11.0934 0 0 P59910 DJB13_HUMAN DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein) DNAJB13 TSARG3 TSARG6 Homo sapiens (Human) axonemal central apparatus assembly [GO:1904158]; chaperone cofactor-dependent protein refolding [GO:0051085] cytosol [GO:0005829]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212] protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] KQDPQVER;VLNEDGYSSTIKDK 2 7 0.97559 -1.4711 0 10.2021 0 0 0 0 0 0 0 0 0 0 P59922 OR2B8_HUMAN Putative olfactory receptor 2B8 (Hs6M1-29P) OR2B8P OR2B8 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LATGQRK 1 2.2 0.78149 0.032051 0 0 0 0 0 0 0 8.09482 0 0 0 0 P59923 ZN445_HUMAN Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) ZNF445 ZFP445 ZKSCAN15 ZNF168 Homo sapiens (Human) epigenetic programing of female pronucleus [GO:0044726]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; double-stranded methylated DNA binding [GO:0010385]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CRVCGKAFR;FHTRERPFK;HMRLHEEEKFYK;LRELCRWWLRPDVLSK 4 4.5 0.97336 -2.8998 0 13.014 0 11.3655 0 7.17023 0 0 0 0 0 0 P59998 ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) ARPC4 ARC20 Homo sapiens (Human) actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; enzyme binding [GO:0019899]; structural constituent of cytoskeleton [GO:0005200] AENFFILR;ELLLQPVTISR 2 11.3 0.9518 -0.6843 0 0 0 0 0 7.69662 0 0 9.38606 0 0 10.3073 P60008 HILS1_HUMAN Putative histone H1.9 (H1.9 linker histone pseudogene) (Putative spermatid-specific linker histone H1-like protein) H1-9P H1-9 HILS1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; chromosome condensation [GO:0030261]; germ cell development [GO:0007281]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] male germ cell nucleus [GO:0001673]; nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; histone binding [GO:0042393]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492] GSAGSFTLGK;QGHKRLIK;YVSLATLK 3 11.3 0.98033 -1.8015 0 0 0 0 0 0 0 0 0 8.20931 0 9.82782 P60033 CD81_HUMAN CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81) CD81 TAPA1 TSPAN28 Homo sapiens (Human) "CD4-positive, alpha-beta T cell costimulation [GO:0035783]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; immunological synapse formation [GO:0001771]; macrophage fusion [GO:0034238]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; osteoclast fusion [GO:0072675]; positive regulation of adaptive immune memory response [GO:1905676]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of receptor clustering [GO:1903911]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to lysosome [GO:0061462]; protein localization to plasma membrane [GO:0072659]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; regulation of protein stability [GO:0031647]" basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; vesicle [GO:0031982] cholesterol binding [GO:0015485]; integrin binding [GO:0005178]; MHC class II protein binding [GO:0042289]; MHC class II protein complex binding [GO:0023026]; transferrin receptor binding [GO:1990459]; virus receptor activity [GO:0001618] QFYDQALQQAVVDDDANNAK;YLLFVFNFVFWLAGGVILGVALWLR 2 19.1 0.57864 0.18095 0 7.5008 0 6.53472 0 0 0 0 8.63695 0 0 0 P60059 SC61G_HUMAN Protein transport protein Sec61 subunit gamma SEC61G Homo sapiens (Human) "post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to ER [GO:0045047]" cytosol [GO:0005829]; membrane [GO:0016020]; Ssh1 translocon complex [GO:0071261] protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022] MDQVMQFVEPSR 1 17.6 0.80848 0.0086843 0 0 4.01453 0 3.2216 0 0 0 0 0 0 0 P60174 TPIS_HUMAN Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) TPI1 TPI Homo sapiens (Human) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096]; methylglyoxal biosynthetic process [GO:0019242] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634] methylglyoxal synthase activity [GO:0008929]; protein homodimerization activity [GO:0042803]; triose-phosphate isomerase activity [GO:0004807]; ubiquitin protein ligase binding [GO:0031625] EAGITEK;HVFGESDELIGQK;IAVAAQNCYK;QSLGELIGTLNAAK;SNVSDAVAQSTR;TATPQQAQEVHEK;VIADNVKDWSK;VPADTEVVCAPPTAYIDFAR;VTNGAFTGEISPGMIK;VVFEQTK;VVLAYEPVWAIGTGK 11 55.4 0 73.23 14.8144 13.6832 14.5159 11.938 11.674 11.5849 13.707 14.498 14.4163 14.0709 14.3367 12.5059 P60228 EIF3E_HUMAN Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) EIF3E EIF3S6 INT6 Homo sapiens (Human) "formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of translational initiation [GO:0045947]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]" "chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; postsynaptic density [GO:0014069]" cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] YLTTAVITNKDVR 1 2.9 0.9181 -0.40487 9.29221 0 0 0 0 0 0 0 0 0 0 0 P60323 NANO3_HUMAN Nanos homolog 3 (NOS-3) NANOS3 NOS3 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; regulation of cell cycle [GO:0051726]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471] enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] RFCPLTGQGYTSVYSHTTR 1 11 0.58702 0.17918 0 0 0 0 0 6.7736 0 0 0 0 0 0 P60370 KR105_HUMAN Keratin-associated protein 10-5 (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5) KRTAP10-5 KAP10.5 KAP18-5 KRTAP10.5 KRTAP18-5 KRTAP18.5 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] AACTMSVCSSACSDSWR 1 6.3 0.67128 0.16808 0 0 0 0 0 0 3.5967 0 0 0 5.61232 0 P60484 PTEN_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)" PTEN MMAC1 TEP1 Homo sapiens (Human) "adult behavior [GO:0030534]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell motility [GO:0048870]; cellular response to electrical stimulus [GO:0071257]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; multicellular organismal response to stress [GO:0033555]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of cellular senescence [GO:2000773]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of neuron projection development [GO:0010977]; negative regulation of organ growth [GO:0046621]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of synaptic vesicle clustering [GO:2000808]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; protein stabilization [GO:0050821]; regulation of neuron projection development [GO:0010975]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of protein stability [GO:0031647]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; spindle assembly involved in female meiosis [GO:0007056]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]" apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; myelin sheath adaxonal region [GO:0035749]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; Schmidt-Lanterman incisure [GO:0043220] "anaphase-promoting complex binding [GO:0010997]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; lipid binding [GO:0008289]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; molecular function inhibitor activity [GO:0140678]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; PDZ domain binding [GO:0030165]; phosphatidylinositol phosphate phosphatase activity [GO:0052866]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-specific protease binding [GO:1990381]" AISILQKKPR;FMYFEFPQPLPVCGDIK;HQQLLPSLSSFFFSHRLPDMTAIIKEIVSR;NHYKIYNLCAER;NHYKIYNLCAERHYDTAK;VEFFHKQNK 6 14.6 0.97522 -3.3005 0 0 5.9246 9.84394 0 0 0 6.2629 0 0 0 0 P60507 EFC1_HUMAN Endogenous retrovirus group FC1 Env polyprotein (Envelope polyprotein) (Fc1env) (HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein) (HERV-Fc1env) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVFC1 Homo sapiens (Human) plasma membrane [GO:0005886] LTLYSEAELSSLVNPPMR 1 3.1 0.8049 0.013603 0 0 0 0 0 0 0 0 0 10.0844 0 0 P60508 SYCY2_HUMAN Syncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVFRD-1 ERVFRDE1 UNQ6191/PRO20218 Homo sapiens (Human) myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768] plasma membrane [GO:0005886] NIQESPF;NSLFWENKTK 2 3.2 0.81325 -0.011466 5.56279 0 11.2025 0 0 0 0 0 9.26812 0 0 0 P60509 ERB1_HUMAN Endogenous retrovirus group PABLB member 1 Env polyprotein (Endogenous retrovirus group PABLB member 1) (Envelope polyprotein) (HERV-R(b) Env protein) (HERV-R(b)_3p24.3 provirus ancestral Env polyprotein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)] ERVPABLB-1 Homo sapiens (Human) plasma membrane [GO:0005886] NISEWPINK 1 1.8 0.90986 -0.3152 0 0 0 0 0 0 0 4.57978 3.21293 0 0 11.0293 P60568 IL2_HUMAN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin) IL2 Homo sapiens (Human) "activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway via STAT [GO:0097696]; cell-cell signaling [GO:0007267]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; interleukin-2-mediated signaling pathway [GO:0038110]; leukocyte activation involved in immune response [GO:0002366]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000561]; regulation of T cell homeostatic proliferation [GO:0046013]; response to ethanol [GO:0045471]; response to tacrolimus [GO:1901327]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]" extracellular region [GO:0005576]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125]; glycosphingolipid binding [GO:0043208]; growth factor activity [GO:0008083]; interleukin-2 receptor binding [GO:0005134]; kappa-type opioid receptor binding [GO:0031851]; kinase activator activity [GO:0019209] YRMQLLSCIALSLALVTNSAPTSSSTK 1 17.6 0.84081 -0.045996 0 0 5.55133 0 0 5.73974 0 0 0 0 0 0 P60604 UB2G2_HUMAN Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2) UBE2G2 UBC7 Homo sapiens (Human) "cellular response to interferon-beta [GO:0035458]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] EQFYKIAK 1 4.8 0.98192 -1.587 0 0 0 0 0 0 10.1655 0 0 0 0 0 P60606 CTXN1_HUMAN Cortexin-1 CTXN1 CTXN Homo sapiens (Human) membrane [GO:0016020] TVFAFVLCLLVVLVLLMVRCVR 1 26.8 0.829 -0.025381 0 0 0 7.66952 0 0 0 0 0 0 0 0 P60660 MYL6_HUMAN Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) MYL6 Homo sapiens (Human) muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519] brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307] ALGQNPTNAEVLK;HVLVTLGEK;ILYSQCGDVMR 3 21.9 0 31.142 13.2245 12.905 13.0295 0 0 0 0 11.5978 12.1457 10.6551 12.3964 9.95845 P60673 PROF3_HUMAN Profilin-3 (Profilin III) PFN3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779]; lipid binding [GO:0008289] ALLVLMGRRGVHGGILNK;AVCVGRAPR;GLDARAVCVGRAPR;TVHELIRGLR 4 30.7 0.97394 -3.0441 13.2028 0 0 0 13.3246 0 0 0 0 0 9.41916 3.84107 P60709 ACTB_HUMAN "Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" ACTB Homo sapiens (Human) adherens junction assembly [GO:0034333]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to cytochalasin B [GO:0072749]; chromatin remodeling [GO:0006338]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of cell differentiation [GO:0045596]; platelet aggregation [GO:0070527]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of norepinephrine uptake [GO:0051623]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of double-strand break repair [GO:2000779]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of norepinephrine uptake [GO:0051621]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transepithelial transport [GO:0150111]; regulation of transmembrane transporter activity [GO:0022898]; substantia nigra development [GO:0021762] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; bBAF complex [GO:0140092]; blood microparticle [GO:0072562]; brahma complex [GO:0035060]; brush border [GO:0005903]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; chromatin [GO:0000785]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GBAF complex [GO:0140288]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; Schaffer collateral - CA1 synapse [GO:0098685]; SWI/SNF complex [GO:0016514]; synapse [GO:0045202]; tight junction [GO:0070160]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; nitric-oxide synthase binding [GO:0050998]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; Tat protein binding [GO:0030957]; tau protein binding [GO:0048156] AGFAGDDAPR;AVFPSIVGRPR;DLTDYLMK;DLYANTVLSGGTTMYPGIADR;DSYVGDEAQSK;DSYVGDEAQSKR;EITALAPSTMK;GYSFTTTAER;GYSFTTTAEREIVR;HQGVMVGMGQK;IIAPPER;IIAPPERK;IKIIAPPER;LCYVALDFEQEMATAASSSSLEK;LDLAGRDLTDYLMK;MQKEITALAPSTMK;QEYDESGPSIVHR;SYELPDGQVITIGNER;TTGIVMDSGDGVTHTVPIYEGYALPHAILR;VAPEEHPVLLTEAPLNPK 20 57.9 0 323.31 19.1842 18.8745 18.8905 13.8886 14.918 13.8573 17.0133 17.0811 17.4544 18.059 18.4417 16.768 P60842 IF4A1_HUMAN Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) EIF4A1 DDX2A EIF4A Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear stress granule [GO:0097165]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; RNA helicase activity [GO:0003724]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" DVIMREFR;EELTLEGIR;ELAQQIQK;GIYAYGFEKPSAIQQR;GVAINMVTEEDK;GYDVIAQAQSGTGK;LQMEAPHIIVGTPGR;MFVLDEADEMLSR;VLITTDLLAR 9 25.9 0 26.144 12.9102 12.259 13.3818 10.663 10.7361 8.99158 12.9118 12.6756 13.3644 12.8233 12.1416 12.7335 P60852 ZP1_HUMAN Zona pellucida sperm-binding protein 1 (Zona pellucida glycoprotein 1) (Zp-1) [Cleaved into: Processed zona pellucida sperm-binding protein 1] ZP1 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468] collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] acrosin binding [GO:0032190]; structural constituent of egg coat [GO:0035804] EACQQAGCCYDNTR 1 2.2 0.80304 0.014255 0 0 0 0 0 0 5.79494 0 0 0 0 0 P60866 RS20_HUMAN Small ribosomal subunit protein uS10 (40S ribosomal protein S20) RPS20 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202] MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] ITLTSRNVK;LIDLHSPSEIVK;TPVEPEVAIHR 3 26.9 0 3.4796 0 0 12.5726 8.87618 11.7346 8.75031 12.1255 9.80631 10.658 0 0 12.3659 P60880 SNP25_HUMAN Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) SNAP25 SNAP Homo sapiens (Human) associative learning [GO:0008306]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; neurotransmitter uptake [GO:0001504]; positive regulation of insulin secretion [GO:0032024]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of insulin secretion [GO:0050796]; regulation of neuron projection development [GO:0010975]; regulation of synapse assembly [GO:0051963]; SNARE complex assembly [GO:0035493]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082] actin cytoskeleton [GO:0015629]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of presynaptic membrane [GO:0098888]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; synaptic vesicle [GO:0008021]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; voltage-gated potassium channel complex [GO:0008076] calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; myosin binding [GO:0017022]; protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] IDEANQR;IEEGMDQINKDMK 2 9.7 0.95875 -1.0048 0 0 0 0 0 0 5.76816 0 9.51049 0 0 0 P60891 PRPS1_HUMAN Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) PRPS1 Homo sapiens (Human) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; urate biosynthetic process [GO:0034418] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749] MELLIMINACKIASASR;MVLVGDVKDR;VTSIADR 3 13.5 0.97578 -2.305 0 0 0 0 0 0 0 0 6.80077 0 0 0 P60900 PSA6_HUMAN Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) PSMA6 PROS27 Homo sapiens (Human) positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of inflammatory response [GO:0050727] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; ribosome [GO:0005840]; sarcomere [GO:0030017]" endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723] AINQGGLTSVAVR;QTESTSFLEK;QTESTSFLEKKVK 3 10.6 0.0024814 1.6777 0 0 12.086 0 0 0 9.99534 9.62443 9.39787 10.4478 10.2582 0 P60903 S10AA_HUMAN Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 ANX2LG CAL1L CLP11 Homo sapiens (Human) membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of exocytosis [GO:0045921]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900] AnxA2-p11 complex [GO:1990665]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; transmembrane transporter binding [GO:0044325] DPLAVDK;GYLTKEDLRVLMEK 2 21.6 0.95332 -0.73073 0 0 0 0 0 0 7.46066 0 7.55167 0 0 0 P60953 CDC42_HUMAN Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein) CDC42 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament organization [GO:0007015]; adherens junction organization [GO:0034332]; cardiac conduction system development [GO:0003161]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; Cdc42 protein signal transduction [GO:0032488]; cell junction assembly [GO:0034329]; cellular response to type II interferon [GO:0071346]; dendritic cell migration [GO:0036336]; dendritic spine morphogenesis [GO:0060997]; embryonic heart tube development [GO:0035050]; endocytosis [GO:0006897]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; heart contraction [GO:0060047]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; modulation by host of viral process [GO:0044788]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; neuropilin signaling pathway [GO:0038189]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of synapse structural plasticity [GO:0051835]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; regulation of mitotic nuclear division [GO:0007088]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of postsynapse organization [GO:0099175]; regulation of stress fiber assembly [GO:0051492]; sprouting angiogenesis [GO:0002040]; submandibular salivary gland formation [GO:0060661]; substantia nigra development [GO:0021762]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; spindle midzone [GO:0051233]; storage vacuole [GO:0000322] apolipoprotein A-I receptor binding [GO:0034191]; G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; ubiquitin protein ligase activity [GO:0061630] NVFDEAILAALEPPEPK;QKPITPETAEK 2 14.7 0 10.04 9.5113 10.1605 10.3229 5.89093 4.72596 0 9.17143 9.23127 9.52619 0 0 8.11046 P60981 DEST_HUMAN Destrin (Actin-depolymerizing factor) (ADF) DSTN ACTDP DSN Homo sapiens (Human) actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; cell motility [GO:0048870]; positive regulation of actin filament depolymerization [GO:0030836] actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynapse [GO:0098793] actin filament binding [GO:0051015] ASGVQVADEVCR;MIYASSK;YALYDASFETK 3 18.2 0 4.7988 0 0 0 0 0 0 0 0 0 10.0308 10.0322 0 P60983 GMFB_HUMAN Glia maturation factor beta (GMF-beta) GMFB Homo sapiens (Human) actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468] cortical actin cytoskeleton [GO:0030864] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860] LVQTAELTK;NTEDLTEEWLREK 2 15.5 0.97843 -1.9422 0 0 8.31854 0 0 0 0 0 0 14.1578 0 0 P61006 RAB8A_HUMAN Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) RAB8A MEL RAB8 Homo sapiens (Human) "autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; Golgi vesicle fusion to target membrane [GO:0048210]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; regulation of autophagy [GO:0010506]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003]" centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein tyrosine kinase binding [GO:1990782]; small GTPase binding [GO:0031267] ITPDQQK;LLLIGDSGVGK;MDKKLEGNSPQGSNQGVK;TIELDGK;TIELDGKR 5 21.3 0.94542 -0.6437 0 0 0 0 0 0 0 9.53829 0 0 6.80941 10.4698 P61009 SPCS3_HUMAN Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit) SPCS3 SPC22 UNQ1841/PRO3567 Homo sapiens (Human) protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] IVLRGDNPKLLLK;YFFFDDGNGLKGNR 2 15 0.88809 -0.18911 0 0 10.4988 3.05299 4.197 0 0 0 0 0 0 0 P61011 SRP54_HUMAN Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein) SRP54 Homo sapiens (Human) "exocrine pancreas development [GO:0031017]; granulocyte differentiation [GO:0030851]; neutrophil chemotaxis [GO:0030593]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; ATP hydrolysis activity [GO:0016887]; endoplasmic reticulum signal peptide binding [GO:0030942]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] GWKTCLICADTFRAGAFDQLK;MIQHAVFK;VLADLGR 3 7.1 0.96551 -1.2429 0 0 0 9.54005 6.40376 0 0 0 0 10.9578 0 0 P61024 CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (CKS-1) CKS1B CKS1 PNAS-143 PNAS-16 Homo sapiens (Human) cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; mitotic cell cycle phase transition [GO:0044772]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] YDDEEFEYR 1 11.4 0.66901 0.16885 0 0 7.19574 0 0 0 0 0 0 0 0 0 P61026 RAB10_HUMAN Ras-related protein Rab-10 (EC 3.6.5.2) RAB10 Homo sapiens (Human) antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; endosome membrane [GO:0010008]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; membrane scission GTPase motor activity [GO:1990606]; myosin V binding [GO:0031489] FFETSAK;LLLIGDSGVGK;VVPKGKGEQIAR 3 15 0.97953 -1.8979 0 0 12.6638 0 0 0 0 0 0 9.73483 0 0 P61077 UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) UBE2D3 UBC5C UBCH5C Homo sapiens (Human) apoptotic process [GO:0006915]; DNA repair [GO:0006281]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein modification process [GO:0036211]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] SQWSPALTISK 1 7.5 0.0089286 1.1423 0 0 0 11.3655 0 0 12.6288 0 0 10.4573 0 0 P61081 UBC12_HUMAN NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) UBE2M UBC12 Homo sapiens (Human) positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842] DINELNLPK 1 4.9 0.76848 0.059687 10.6284 0 0 0 0 0 0 0 0 9.48573 0 0 P61086 UBE2K_HUMAN Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase) UBE2K HIP2 LIG Homo sapiens (Human) cellular response to interferon-beta [GO:0035458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium tip [GO:0032433]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] NAVIVALSSK 1 5 0.8982 -0.23502 0 0 0 0 0 0 0 0 0 11.8356 0 0 P61088 UBE2N_HUMAN Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) UBE2N BLU Homo sapiens (Human) antiviral innate immune response [GO:0140374]; DNA double-strand break processing [GO:0000729]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]; regulation protein catabolic process at postsynapse [GO:0140252]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151] ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842] LLAEPVPGIK;TNEAQAIETAR 2 13.8 0 2.2884 11.8004 12.2572 11.8928 8.7057 8.51227 7.88142 0 10.732 0 10.0312 10.2002 10.3869 P61106 RAB14_HUMAN Ras-related protein Rab-14 (EC 3.6.5.2) RAB14 Homo sapiens (Human) defense response to bacterium [GO:0042742]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; phagolysosome assembly [GO:0001845]; phagosome maturation [GO:0090382]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] GAAGALMVYDITR;LTSEPQPQR;TGENVEDAFLEAAK 3 16.7 0 4.508 0 0 0 0 0 9.84883 0 8.6287 8.50585 9.18807 10.0815 0 P61129 ZC3H6_HUMAN Zinc finger CCCH domain-containing protein 6 ZC3H6 KIAA2035 ZC3HDC6 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] chromatin [GO:0000785]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] EAKENEK;HKHNSPSSDDSSDYSLDSDVEHTESSHK 2 2.9 0.9106 -0.31647 7.48228 0 0 0 0 0 0 0 3.6472 0 0 0 P61158 ARP3_HUMAN Actin-related protein 3 (Actin-like protein 3) ACTR3 ARP3 Homo sapiens (Human) actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653] actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200] LSEELSGGR;VGDQAQR;VGDQAQRR;VGDQAQRRVMK;YSYVCPDLVK 5 7.2 0.95253 -0.73782 11.1785 7.96278 0 0 0 7.50978 9.00324 11.7251 11.6812 6.74201 0 2.25728 P61160 ARP2_HUMAN Actin-related protein 2 (Actin-like protein 2) ACTR2 ARP2 Homo sapiens (Human) Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; cytosolic transport [GO:0016482]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653] actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; azurophil granule lumen [GO:0035578]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200] ILLTEPPMNPTK;LNIDTRNCK;YLIKLLLLR 3 7.6 0.95206 -0.70251 9.9609 2.66334 11.2838 0 0 0 0 0 0 7.14782 0 0 P61163 ACTZ_HUMAN Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) ACTR1A CTRN1 Homo sapiens (Human) vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630] ATP binding [GO:0005524] AGFAGDQIPK;AQYYLPDGSTIEIGPSR;DWNDMERIWQYVYSK;IDIAGRDVSR;ISAPQER;LLSEVKK 6 17.6 0.96699 -1.2886 0 0 0 0 6.75502 0 7.87067 0 0 8.54863 10.3879 0 P61201 CSN2_HUMAN COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) COPS2 CSN2 TRIP15 Homo sapiens (Human) inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell proliferation [GO:0001834] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714] ALKEDDPK;LYLEREEYGK;QLHQSCQTDDGEDDLK;YKQLLTYIRSAVTR 4 10.8 0.97497 -4.0562 0 0 6.39017 0 7.77597 0 0 0 9.55482 0 0 0 P61204 ARF3_HUMAN ADP-ribosylation factor 3 ARF3 Homo sapiens (Human) "intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]" extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ILMVGLDAAGK;MGNIFGNLLKSLIGK 2 14.4 0.88281 -0.17403 0 0 0 6.2422 0 0 0 0 0 0 0 0 P61224 RAP1B_HUMAN Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) RAP1B OK/SW-cl.11 Homo sapiens (Human) calcium-ion regulated exocytosis [GO:0017156]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; establishment of localization in cell [GO:0051649]; modification of postsynaptic structure [GO:0099010]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of integrin activation [GO:0033625]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of cell polarity [GO:2000114] azurophil granule membrane [GO:0035577]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877] EQGQNLAR;LVVLGSGGVGK;QINRKTPVPGK 3 16.3 0.94034 -0.58039 0 10.0697 0 0 0 10.806 0 0 0 9.98925 10.8066 14.3212 P61225 RAP2B_HUMAN Ras-related protein Rap-2b (EC 3.6.5.2) RAP2B Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein domain specific binding [GO:0019904] YDPTIEDFYRK 1 6 0.73488 0.11099 10.0676 10.7285 0 0 0 0 0 0 0 0 0 0 P61247 RS3A_HUMAN Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) RPS3A FTE1 MFTL Homo sapiens (Human) cell differentiation [GO:0030154]; cytoplasmic translation [GO:0002181]; negative regulation of apoptotic process [GO:0043066]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040] mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ADGYEPPVQESV;APAMFNIR;EVQTNDLKEVVNK;GGKKGAK;LFCVGFTKK;LITEDVQGK;MMEIMTR;TTDGYLLR;VVDPFSK 9 30.3 0 24.588 13.3122 13.3872 11.632 8.25465 0 0 0 11.1799 12.6132 12.7735 10.6326 12.0679 P61254 RL26_HUMAN Large ribosomal subunit protein uL24 (60S ribosomal protein L26) RPL26 Homo sapiens (Human) "cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cytoplasmic translation [GO:0002181]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902167]; positive regulation of translation [GO:0045727]; regulation of translation involved in cellular response to UV [GO:1904803]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DDEVQVVR;FNPFVTSDR;YVIYIER 3 16.6 0.90937 -0.27816 0 0 12.5951 0 0 0 11.5117 11.7397 11.5867 0 10.3413 10.7066 P61289 PSME3_HUMAN Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) PSME3 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039] ITSEAEDLVANFFPK;SNQQLVDIIEK;VFVMPNGMLK 3 14.2 0.93583 -0.52814 11.0759 9.93406 0 9.67099 0 0 0 11.1756 0 0 0 0 P61313 RL15_HUMAN Large ribosomal subunit protein eL15 (60S ribosomal protein L15) RPL15 EC45 TCBAP0781 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; response to ethanol [GO:0045471]; translation [GO:0006412] A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FARSLQSVAEER;NPDTQWITKPVHK;NTLQLHR;QLSALHRAPRPTRPDK;SLQSVAEER;YIQELWR 6 27 0.2277 0.30217 12.9691 12.8078 0 9.93754 9.71925 9.82346 12.2623 10.6014 10.5001 11.9226 12.0164 12.2456 P61326 MGN_HUMAN Protein mago nashi homolog MAGOH MAGOHA Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] IGSLIDVNQSK;MESDFYLR;VFYYLVQDLK;YANNSNYK 4 25.3 0.012632 0.92601 0 0 0 0 0 0 0 0 0 0 9.29142 0 P61328 FGF12_HUMAN Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor) FGF12 FGF12B FHF1 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; heart development [GO:0007507]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuromuscular process [GO:0050905]; positive regulation of sodium ion transport [GO:0010765]; regulation of neuronal action potential [GO:0098908]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of voltage-gated sodium channel activity [GO:1905150]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; synapse [GO:0045202] growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] RPEPQLKGIVTR;VRFCSGRK;VSASKRR 3 11.1 0.975 -3.1367 0 0 0 0 0 0 0 0 0 0 8.75802 0 P61353 RL27_HUMAN Large ribosomal subunit protein eL27 (60S ribosomal protein L27) RPL27 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; response to aldosterone [GO:1904044]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] YSVDIPLDK 1 6.6 0 2.1792 0 11.6838 11.4701 0 0 10.811 12.1668 11.6678 12.1862 11.1285 11.179 12.0164 P61371 ISL1_HUMAN Insulin gene enhancer protein ISL-1 (Islet-1) ISL1 Homo sapiens (Human) atrial septum morphogenesis [GO:0060413]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac right ventricle morphogenesis [GO:0003215]; cell population proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; endocardial cushion morphogenesis [GO:0003203]; heart development [GO:0007507]; innervation [GO:0060384]; mesenchymal cell differentiation [GO:0048762]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuron fate specification [GO:0048665]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; pharyngeal system development [GO:0060037]; pituitary gland development [GO:0021983]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage colony-stimulating factor production [GO:1901258]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; retinal ganglion cell axon guidance [GO:0031290]; secondary heart field specification [GO:0003139]; sensory system development [GO:0048880]; sinoatrial node cell development [GO:0060931]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]; trigeminal nerve development [GO:0021559]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral motor neuron differentiation [GO:0021524] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" QPEKTTRVR;VWFQNKR 2 4.6 0.80422 0.013452 8.74963 0 0 9.70853 0 0 0 0 0 0 0 0 P61550 ENVT1_HUMAN Endogenous retrovirus group S71 member 1 Env polyprotein (Envelope polyprotein) (HERV-T Env protein) (HERV-T_19q13.11 provirus ancestral Env polyprotein) [Includes: Surface protein (SU); Transmembrane protein (TM)] ERVS71-1 Homo sapiens (Human) plasma membrane [GO:0005886] GPLSCHTRPR;LAQDCWLCLKAKPPYYVGLGVEATLK 2 5.8 0.94078 -0.58646 8.47598 0 0 0 0 0 0 0 0 0 0 10.4797 P61565 ENK21_HUMAN Endogenous retrovirus group K member 21 Env polyprotein (EnvK1 protein) (Envelope polyprotein) (HERV-K_12q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVK-21 Homo sapiens (Human) plasma membrane [GO:0005886] structural molecule activity [GO:0005198] EDNLTLDISK;FTYNMVSGMSLRPR;LANQINDLR;MVTSEQMK 4 5.9 0.9813 -1.7738 0 0 0 0 9.2866 0 0 0 0 0 0 8.09887 P61578 REC16_HUMAN Endogenous retrovirus group K member 16 Rec protein (HERV-K_10p14 provirus Rec protein) ERVK-16 Homo sapiens (Human) mRNA transport [GO:0051028] cytoplasm [GO:0005737]; nucleolus [GO:0005730] RNA binding [GO:0003723] NPSEMQRK;NRAPSSHKMNK 2 18.1 0.97779 -1.5188 0 0 0 0 0 0 0 0 0 0 0 15.0745 P61580 NP10_HUMAN Endogenous retrovirus group K member 10 Np9 protein (HERV-K10 Np9 protein) (HERV-K107 Np9 protein) (HERV-K_5q33.3 provirus Np9 protein) ERVK-10 Homo sapiens (Human) nucleus [GO:0005634] NPSEMQRK;SNCYCVCVER 2 24 0.81109 0.0037274 0 0 0 0 0 0 0 0 0 0 0 4.82889 P61583 NP5_HUMAN Endogenous retrovirus group K member 5 Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) (HERV-K_3q12.3 provirus Np9 protein) ERVK-5 ERVK5 Homo sapiens (Human) nucleus [GO:0005634] NPSEMQRK;SDCYCVCVER 2 24 0.80951 0.0096436 0 5.18959 0 0 0 0 0 0 0 0 0 0 P61587 RND3_HUMAN Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3) RND3 ARHE RHO8 RHOE Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] ISHMPSRPELSAVATDLRKDK;TALLHVFAK 2 12.3 0.87377 -0.11495 0 0 0 0 0 0 0 0 9.74985 0 9.42103 0 P61599 NAA20_HUMAN N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit) NAA20 NAT5 Homo sapiens (Human) N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-glutamine acetylation [GO:0017192]; N-terminal protein amino acid acetylation [GO:0006474]; regulation of actin cytoskeleton organization [GO:0032956] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]; nucleus [GO:0005634] peptide alpha-N-acetyltransferase activity [GO:0004596] LMELLEEISER 1 6.2 0.89697 -0.23447 0 0 0 0 0 0 0 0 0 9.23714 0 0 P61601 NCALD_HUMAN Neurocalcin-delta NCALD Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; regulation of signal transduction [GO:0009966]; regulation of systemic arterial blood pressure [GO:0003073]; vesicle-mediated transport [GO:0016192] clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytosol [GO:0005829] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; tubulin binding [GO:0015631] LKWAFSMYDLDGNGYISK;SDPSIVR 2 13 0.96534 -1.2475 0 0 0 9.27845 0 0 0 0 0 0 0 0 P61604 CH10_HUMAN "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1)" HSPE1 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; intrinsic apoptotic signaling pathway [GO:0097193]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] AGQAFRK;DGDILGK;FLPLFDR;GGEIQPVSVK;GGIMLPEK;SAAETVTK;VGDKVLLPEYGGTK;VLLPEYGGTK;VLQATVVAVGSGSK 9 73.5 0 34.842 15.4353 14.8695 14.9223 10.567 9.8418 9.81044 9.55351 0 11.079 11.7166 12.1009 11.5615 P61619 S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) SEC61A1 SEC61A Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; pronephric nephron development [GO:0039019]; protein insertion into ER membrane [GO:0045048]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784] calcium channel activity [GO:0005262]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048] EQSEVGSMGALLF;TWIEVSGSSAK 2 5 0.95477 -0.80339 0 0 0 0 0 0 0 0 0 9.15469 0 10.3059 P61626 LYSC_HUMAN "Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)" LYZ LZM Homo sapiens (Human) antimicrobial humoral response [GO:0019730]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] identical protein binding [GO:0042802]; lysozyme activity [GO:0003796] KALIVLGLVLLSVTVQGK;KALIVLGLVLLSVTVQGKVFER 2 14.9 0.74914 0.084509 0 9.38985 0 0 0 0 0 4.97407 0 0 0 0 P61647 SIA8F_HUMAN "Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI)" ST8SIA6 SIAT8F Homo sapiens (Human) blastocyst hatching [GO:0001835]; carbohydrate biosynthetic process [GO:0016051]; ganglioside biosynthetic process [GO:0001574]; glycolipid biosynthetic process [GO:0009247]; glycoprotein metabolic process [GO:0009100]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]" MRPGGALLALLASLLLLLLLR;QKVLFFHPK;RPGGALLALLASLLLLLLLR;VLFFHPK;VLFFHPKYLKDLALFWR 5 10.1 0.96503 -1.1496 0 9.25541 3.8847 0 9.6525 4.57071 7.89282 6.97441 9.68935 11.0752 8.74174 6.97039 P61758 PFD3_HUMAN Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) VBP1 PFDN3 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082] AAVKDSCGK;VYNWDVK 2 8.1 0.97941 -2.0434 0 8.26365 8.56811 0 0 0 0 0 11.9741 0 0 0 P61764 STXB1_HUMAN Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) STXBP1 UNC18A Homo sapiens (Human) "axon target recognition [GO:0007412]; cellular response to type II interferon [GO:0071346]; developmental process involved in reproduction [GO:0003006]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neuron apoptotic process [GO:0051402]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vesicle docking [GO:0106022]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of acrosomal vesicle exocytosis [GO:2000367]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; regulation of synaptic vesicle priming [GO:0010807]; response to estradiol [GO:0032355]; SNARE complex assembly [GO:0035493]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]; vesicle docking involved in exocytosis [GO:0006904]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; postsynapse [GO:0098794]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141] identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] GEYKDNALLAQLIQDKLDAYK;IRIILLYIFLK;IRIILLYIFLKNGITEENLNK 3 7.1 0.84892 -0.077312 0 0 0 7.67066 0 0 0 6.55505 0 0 10.9135 0 P61769 B2MG_HUMAN Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] B2M CDABP0092 HDCMA22P Homo sapiens (Human) "amyloid fibril formation [GO:1990000]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cellular response to iron ion [GO:0071281]; cellular response to iron(III) ion [GO:0071283]; cellular response to nicotine [GO:0071316]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; learning or memory [GO:0007611]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; negative regulation of receptor binding [GO:1900121]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of cellular senescence [GO:2000774]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of immune response [GO:0050778]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein homotetramerization [GO:0051289]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]; regulation of iron ion transport [GO:0034756]; response to molecule of bacterial origin [GO:0002237]; sensory perception of smell [GO:0007608]; T cell differentiation in thymus [GO:0033077]; T cell mediated cytotoxicity [GO:0001913]" cytosol [GO:0005829]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; HFE-transferrin receptor complex [GO:1990712]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; MHC class II protein complex [GO:0042613]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] IQVYSRHPAENGK 1 10.9 0.92152 -0.4466 12.3884 0 0 0 0 0 0 0 0 0 0 0 P61923 COPZ1_HUMAN Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) COPZ1 COPZ CGI-120 HSPC181 Homo sapiens (Human) "intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] MEALILEPSLYTVK;NIFNKTHR;VLQSAKEQIKWSLLR 3 23.1 0 2.6907 9.41819 9.68329 9.46913 9.78656 0 8.40378 0 0 0 0 0 9.04048 P61960 UFM1_HUMAN Ubiquitin-fold modifier 1 UFM1 C13orf20 BM-002 Homo sapiens (Human) brain development [GO:0007420]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein import into nucleus [GO:0042308]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ITLTSDPR 1 9.4 0.91378 -0.39033 0 0 0 0 0 0 11.5019 0 0 0 12.7303 0 P61962 DCAF7_HUMAN DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog) DCAF7 HAN11 WDR68 Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] protein-macromolecule adaptor activity [GO:0030674] SLHGKRK 1 2 0.812 -0.013962 0 0 0 9.69538 8.87731 0 0 0 0 0 0 0 P61964 WDR5_HUMAN WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) WDR5 BIG3 Homo sapiens (Human) gluconeogenesis [GO:0006094]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; skeletal system development [GO:0001501]; transcription initiation-coupled chromatin remodeling [GO:0045815] ATAC complex [GO:0140672]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; mitotic spindle [GO:0072686]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; methylated histone binding [GO:0035064] TLPAHSDPVSAVHFNR;TYTGHKNEK 2 7.5 0.95322 -0.73098 0 0 0 0 0 9.23852 0 0 0 0 0 0 P61966 AP1S1_HUMAN AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) AP1S1 AP19 CLAPS1 Homo sapiens (Human) basolateral protein secretion [GO:0110010]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; response to virus [GO:0009615]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615] DLKVVYKR 1 5.1 0.87086 -0.095167 0 0 0 0 0 0 0 0 0 0 6.63983 0 P61968 LMO4_HUMAN LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4) LMO4 Homo sapiens (Human) motor neuron axon guidance [GO:0008045]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of kinase activity [GO:0033674]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell activation [GO:0050865]; regulation of cell fate specification [GO:0042659]; regulation of cell migration [GO:0030334]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thymus development [GO:0048538]; ventral spinal cord interneuron differentiation [GO:0021514]; ventricular septum development [GO:0003281] cell leading edge [GO:0031252]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AQGNVYHLK;CAGCGGK 2 9.7 0.95609 -0.83765 0 0 5.74927 5.81916 0 0 0 10.5681 6.5443 0 0 0 P61970 NTF2_HUMAN Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) NUTF2 NTF2 Homo sapiens (Human) mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nuclear pore [GO:0090204] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; structural constituent of nuclear pore [GO:0017056] LALHNFG;LSSLPFQK 2 11.8 0.013944 0.81432 12.8205 0 12.8106 10.7366 0 0 12.8832 12.1688 12.546 11.4116 11.4641 11.6789 P61978 HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) HNRNPK HNRPK Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; random inactivation of X chromosome [GO:0060816]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA processing [GO:0006396]; signal transduction [GO:0007165]" catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; ribonucleoprotein complex [GO:1990904] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] DLAGSIIGK;DYDDMSPR;ENTQTTIK;GGDLMAYDR;GSYGDLGGPIITTQVTIPK;IDEPLEGSEDR;IILDLISESPIK;METEQPEETFPNTETNGEFGK;NAGAVIGK;NLPLPPPPPPR;NTDEMVELR;QIRHESGASIK;TDYNASVSVPDSSGPER;VVLIGGKPDR 14 35.2 0 62.654 13.7438 13.3133 13.9593 11.0645 11.5847 11.5622 14.1132 13.9073 14.1192 14.1948 14.0646 11.6765 P61981 1433G_HUMAN "14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]" YWHAG Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; cellular response to insulin stimulus [GO:0032869]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein localization [GO:0008104]; protein targeting [GO:0006605]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of signal transduction [GO:0009966]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; presynapse [GO:0098793] identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; protein sequestering activity [GO:0140311]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723] ATVVESSEK;DSTLIMQLLR;LAEQAER;LAEQAERYDDMAAAMK;NLLSVAYK;NVTELNEPLSNEER;VDREQLVQK;YDDMAAAMK;YLAEVATGEK 9 30.8 0 24.563 8.91782 8.50537 8.80433 0 7.27025 7.96185 10.5474 11.6951 11.4677 12.0555 12.2575 0 P62068 UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) USP46 Homo sapiens (Human) "adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872] VGVIPPK;YTKLSYRVVFPLELR;YYCETCCSK;YYCETCCSKQEAQK 4 10.2 0.95307 -0.73413 5.40337 6.30054 0 4.33414 0 0 0 0 0 7.46107 0 0 P62070 RRAS2_HUMAN Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene) RRAS2 TC21 Homo sapiens (Human) osteoblast differentiation [GO:0001649]; positive regulation of Schwann cell migration [GO:1900149]; Ras protein signal transduction [GO:0007265]; Schwann cell migration [GO:0036135] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] FQEQECPPSPEPTR;TGEGFLLVFSVTDRGSFEEIYKFQR 2 19.1 0.84546 -0.06544 0 11.3743 0 0 0 0 0 0 0 0 7.10465 0 P62079 TSN5_HUMAN Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9) TSPAN5 TM4SF9 Homo sapiens (Human) positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; regulation of membrane protein ectodomain proteolysis [GO:0051043] actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] enzyme binding [GO:0019899] MSGKHYKGPEVSCCIK 1 6 0.8513 -0.079275 0 0 0 0 0 0 0 0 0 0 0 9.77083 P62081 RS7_HUMAN Small ribosomal subunit protein eS7 (40S ribosomal protein S7) RPS7 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] AIIIFVPVPQLK;DVNFEFPEFQL;ELNITAAK;HVVFIAQRRILPKPTR;LTGKDVNFEFPEFQL;VETFSGVYK 6 30.9 0 11.214 0 7.55635 9.69851 0 8.59649 0 14.8312 10.4808 9.88593 12.9426 0 8.83555 P62136 PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) PPP1CA PPP1A Homo sapiens (Human) branching morphogenesis of an epithelial tube [GO:0048754]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation in response to stress [GO:0043558]; response to lead ion [GO:0010288]; telomere maintenance in response to DNA damage [GO:0043247] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; protein phosphatase type 1 complex [GO:0000164]; PTW/PP1 phosphatase complex [GO:0072357] cadherin binding involved in cell-cell adhesion [GO:0098641]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; iron ion binding [GO:0005506]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; transition metal ion binding [GO:0046914] GLCLKSREIFLSQPILLELEAPLK;IKYPENFFLLR;LLEVQGSRPGK 3 13.9 0.72676 0.12525 0 4.94158 0 9.20797 0 0 11.6257 0 0 0 0 0 P62140 PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) PPP1CB Homo sapiens (Human) cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] ADGELNVDSLITR;IKYPENFFLLR;YQYGGLNSGRPVTPPR 3 12.2 0 6.6023 0 11.8806 0 0 0 11.101 0 4.45713 0 9.73929 9.59744 11.3781 P62191 PRS4_HUMAN 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) PSMC1 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; RNA binding [GO:0003723] EIQRTMLELLNQLDGFDSR;IEFPLPDEK;IEFPLPDEKTKK;YLGDGPK 4 8.6 0.97835 -2.0805 0 0 0 0 0 0 0 0 11.8902 9.22579 0 0 P62195 PRS8_HUMAN 26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG) PSMC5 SUG1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357] "blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; proteasome-activating activity [GO:0036402]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription factor binding [GO:0008134] DSEKNMSIK;GVLLYGPPGTGK;KIEFPPPNEEAR 3 8.1 0.94425 -0.63601 8.42164 0 0 0 0 0 0 0 0 0 0 10.0316 P62241 RS8_HUMAN Small ribosomal subunit protein eS8 (40S ribosomal protein S8) RPS8 OK/SW-cl.83 Homo sapiens (Human) "cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ADGYVLEGK;IIDVVYNASNNELVR;ISSLLEEQFQQGK;NCIVLIDSTPYR 4 23.6 0 8.0824 0 10.531 5.93182 10.1134 0 9.27396 11.0631 10.9792 12.7382 10.4963 10.3916 0 P62244 RS15A_HUMAN Small ribosomal subunit protein uS8 (40S ribosomal protein S15a) RPS15A OK/SW-cl.82 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; response to virus [GO:0009615]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FDVQLKDLEK;LNKCGVISPR;MNVLADALK;SINNAEKR 4 28.5 0.9615 -1.0655 0 0 0 8.38927 8.21412 0 11.8865 0 12.3165 0 0 0 P62249 RS16_HUMAN Small ribosomal subunit protein uS9 (40S ribosomal protein S16) RPS16 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALVAYYQK;FAGVDIR;GPLQSVQVFGR;LLEPVLLLGK;TLLVADPR;TLQYKLLEPVLLLGKER;VNGRPLEMIEPR;YVDEASK 8 47.9 0 4.6721 11.4594 10.359 11.2867 7.56018 6.9847 7.35509 12.5418 12.2739 12.3126 9.41642 10.9232 11.1454 P62256 UBE2H_HUMAN Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) UBE2H Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] EQEEGTGDSSSESSMSDFSEDEAQDMEL;RMDTDVVK 2 19.7 0.94431 -0.63494 6.14055 0 0 0 0 0 0 0 0 0 0 0 P62258 1433E_HUMAN 14-3-3 protein epsilon (14-3-3E) YWHAE Homo sapiens (Human) cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; cytoplasmic sequestering of protein [GO:0051220]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; neuron migration [GO:0001764]; positive regulation of hippo signaling [GO:0035332]; positive regulation of protein export from nucleus [GO:0046827]; protein localization [GO:0008104]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to nucleus [GO:0034504]; protein targeting [GO:0006605]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane repolarization [GO:0060306]; regulation of mitotic cell cycle [GO:0007346]; regulation of potassium ion transmembrane transport [GO:1901379]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] cadherin binding [GO:0045296]; calcium channel inhibitor activity [GO:0019855]; calcium channel regulator activity [GO:0005246]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] AASDIAMTELPPTHPIR;DSTLIMQLLR;EAAENSLVAYK;EALQDVEDENQ;IISSIEQK;IISSIEQKEENK;LAEQAER;MDDREDLVYQAK;NLLSVAYK;NVIGARRASWR;QMVETELK;VAGMDVELTVEER;YLAEFATGNDR;YLAEFATGNDRK 14 51.8 0 59.932 15.0974 15.064 14.6644 11.8563 11.6448 11.9237 13.5615 13.7993 14.3591 14.1688 14.6022 13.2678 P62263 RS14_HUMAN Small ribosomal subunit protein uS11 (40S ribosomal protein S14) RPS14 PRO2640 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; small-subunit processome [GO:0032040] mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] DESSPYAAMLAAQDVAQR;IEDVTPIPSDSTR;IEDVTPIPSDSTRR;TPGPGAQSALR 4 28.5 0 14.046 13.125 13.2523 13.51 11.1632 0 8.2848 11.3276 11.8718 11.7237 13.6639 13.5473 11.858 P62266 RS23_HUMAN Small ribosomal subunit protein uS12 (40S ribosomal protein S23) RPS23 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; ribosomal small subunit biogenesis [GO:0042274]; stress granule assembly [GO:0034063]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; rough endoplasmic reticulum [GO:0005791]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FKVVKVANVSLLALYK;GHAVGDIPGVR;QPNSAIR;VANVSLLALYK;VVKVANVSLLALYKGK 5 25.2 0.0046296 1.3306 0 3.8513 0 0 9.07532 8.82645 11.5181 11.8095 11.4822 9.78116 9.28193 11.1789 P62269 RS18_HUMAN Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3) RPS18 D6S218E Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] AGELTEDEVER;IPDWFLNRQK;RYAHVVLRK;VITIMQNPR;VLNTNIDGR;YSQVLANGLDNK 6 39.5 0 11.907 13.7342 0 11.953 0 9.04431 9.86394 10.8041 0 0 13.3691 12.6959 11.2343 P62277 RS13_HUMAN Small ribosomal subunit protein uS15 (40S ribosomal protein S13) RPS13 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] FVTGNKILRILK;GLSQSALPYR;GLTPSQIGVILR;KGLTPSQIGVILR;LTSDDVKEQIYK 5 31.1 0 2.1531 0 12.3907 0 6.77558 0 7.38241 13.6054 10.5235 10.1697 0 10.9943 9.8677 P62280 RS11_HUMAN Small ribosomal subunit protein uS17 (40S ribosomal protein S11) RPS11 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] ADIQTER;ILSGVVTK;VLLGETGK;VLLGETGKEK 4 15.8 0.012658 0.94298 0 0 11.2495 0 0 0 0 0 0 10.9559 10.0855 0 P62304 RUXE_HUMAN Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) SNRPE Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] RNA binding [GO:0003723] VMVQPINLIFR;YLQNRSR 2 19.6 0.8985 -0.25694 0 10.1658 0 0 0 8.03864 9.47255 6.7845 10.2617 11.6977 0 0 P62306 RUXF_HUMAN Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) SNRPF PBSCF Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] RNA binding [GO:0003723] GVEEEEEDGEMRE;SLPLNPKPFLNGLTGKPVMVKLK 2 41.9 0.0046729 1.363 0 0 0 6.36001 0 0 0 0 4.76299 0 8.87015 0 P62308 RUXG_HUMAN Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) SNRPG PBSCG Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446] GNSIIMLEALERV 1 17.1 0.91039 -0.2819 7.4957 0 0 0 0 0 0 9.47974 0 0 0 0 P62316 SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) SNRPD2 SNRPD1 Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] NPLIAGK;SEMTPEELQK;SLLNKPK 3 20.3 0.0086207 1.0243 0 8.21587 0 0 0 9.27359 0 0 0 0 10.0437 0 P62316 SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) SNRPD2 SNRPD1 Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] MTPEELQK;NPLIAGK 2 13.9 0.91441 -0.39033 8.42882 0 0 0 0 0 0 0 0 0 0 0 P62318 SMD3_HUMAN Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) SNRPD3 Homo sapiens (Human) "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] enzyme binding [GO:0019899]; histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U7 snRNA binding [GO:0071209] FLILPDMLK;VAQLEQVYIR 2 15.1 0 2.2772 9.77693 0 9.58554 0 0 0 10.256 0 0 0 0 0 P62328 TYB4_HUMAN Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)] TMSB4X TB4X THYB4 TMSB4 Homo sapiens (Human) "actin filament organization [GO:0007015]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] actin monomer binding [GO:0003785]; enzyme binding [GO:0019899]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723] ETIEQEK;SDKPDMAEIEK;SDKPDMAEIEKFDK 3 47.7 0 4.7205 0 0 0 0 0 0 11.406 11.3307 11.2739 0 0 12.3867 P62333 PRS10_HUMAN 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) PSMC6 SUG2 Homo sapiens (Human) ERAD pathway [GO:0036503]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]; protein-macromolecule adaptor activity [GO:0030674] LDILKIHAGPITK;VGIIPPK;YIGESAR 3 6.9 0.96422 -1.0941 0 4.42156 0 0 7.06706 6.62356 0 0 0 8.43087 0 0 P62341 SELT_HUMAN Thioredoxin reductase-like selenoprotein T (SelT) (EC 1.8.1.9) SELENOT SELT UNQ150/PRO176 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glucose homeostasis [GO:0042593]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; pancreas development [GO:0031016]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of growth hormone secretion [GO:0060124]; response to glucose [GO:0009749]; selenocysteine incorporation [GO:0001514] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] selenium binding [GO:0008430]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] LLLLLLVAASAMVR;LVLIGLIIVGK;RLKMQYATGPLLK 3 19.5 0.059122 0.44326 0 0 0 8.32751 2.13763 3.70797 0 9.37032 0 0 0 0 P62424 RL7A_HUMAN Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) RPL7A SURF-3 SURF3 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AGVNTVTTLVENKK;KVVNPLFEK;NFGIGQDIQPK;QTATQLLK;VAPAPAVVK;VPPAINQFTQALDR;VPPAINQFTQALDRQTATQLLK;VVNPLFEK 8 24.4 0 7.7694 12.1953 10.1951 13.7268 0 9.81639 9.19037 12.8102 12.4029 0 12.6266 12.916 11.922 P62491 RB11A_HUMAN Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) RAB11A RAB11 Homo sapiens (Human) "amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; early endosome to recycling endosome transport [GO:0061502]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; Golgi to plasma membrane protein transport [GO:0043001]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein transmembrane transport [GO:0071806]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]" centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; vesicle [GO:0031982] dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905] AQIWDTAGQER;AVPTDEAR;STIGVEFATR;VVLIGDSGVGK 4 18.5 0.012024 0.83375 0 10.3264 10.7002 0 0 0 0 0 0 0 10.9401 0 P62495 ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) ETF1 ERF1 RF1 SUP45L1 Homo sapiens (Human) "cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444] "aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]" LSVLGAITSVQQRLKLYNK 1 4.3 0.8632 -0.083469 0 0 0 6.96035 0 0 8.97083 0 0 0 0 0 P62508 ERR3_HUMAN Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) ESRRG ERR3 ERRG2 KIAA0832 NR3B3 Homo sapiens (Human) nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "AF-2 domain binding [GO:0050682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" LAGLLDLNNAILQLVK 1 3.5 0.59763 0.17847 0 0 0 0 0 0 0 0 6.467 0 0 0 P62633 CNBP_HUMAN CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9) CNBP RNF163 ZNF9 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; G-quadruplex DNA formation [GO:0071919]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] G-quadruplex DNA binding [GO:0051880]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270] DCDHADEQK;DCDLQEDEACYNCGR 2 13.5 0.74472 0.097699 0 0 0 0 0 7.31125 0 4.567 0 8.00748 0 0 P62701 RS4X_HUMAN "Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein)" RPS4X CCG2 RPS4 SCAR Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] DANGNSFATR;IGVITNR;ITPEEAK;LSNIFVIGK;LSNIFVIGKGNKPWISLPR;LTIAEER;TDITYPAGFMDVISIDK 7 25.5 0 3.8997 12.6084 11.6402 12.5545 0 9.31798 9.01173 11.9097 11.6406 10.8467 12.0022 12.6166 9.63778 P62750 RL23A_HUMAN Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) RPL23A Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841] EAPAPPK;LAPDYDALDVANK;LAPDYDALDVANKIGII;LYDIDVAK;VNTLIRPDGEKK 5 28.2 0 2.9016 0 11.4823 0 8.50938 8.27598 0 8.52458 10.8674 11.0013 9.67271 7.92772 0 P62753 RS6_HUMAN Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) RPS6 OK/SW-cl.2 Homo sapiens (Human) activation-induced cell death of T cells [GO:0006924]; cytoplasmic translation [GO:0002181]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; glucose homeostasis [GO:0042593]; mammalian oogenesis stage [GO:0022605]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DIPGLTDTTVPR;MATEVAADALGEEWKGYVVR 2 12.9 0.0025063 1.746 11.3723 12.2195 12.3545 9.1729 9.42101 9.77203 11.9741 12.3397 11.934 11.5889 11.9469 11.3262 P62760 VISL1_HUMAN Visinin-like protein 1 (VILIP) (VLP-1) (Hippocalcin-like protein 3) (HLP3) VSNL1 VISL1 Homo sapiens (Human) negative regulation of insulin secretion [GO:0046676]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; membrane [GO:0016020] calcium ion binding [GO:0005509] LAPEVMEDLVK 1 5.8 0.017208 0.70258 0 14.4662 0 0 0 0 0 0 0 0 0 0 P62805 H4_HUMAN Histone H4 H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of megakaryocyte differentiation [GO:0045653]; nucleosome assembly [GO:0006334]; protein localization to CENP-A containing chromatin [GO:0061644]; telomere organization [GO:0032200] "CENP-A containing nucleosome [GO:0043505]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] DAVTYTEHAK;DNIQGITKPAIR;ISGLIYEETR;ISGLIYEETRGVLK;TLYGFGG;TVTAMDVVYALK;TVTAMDVVYALKR;VFLENVIR;VFLENVIRDAVTYTEHAK 9 62.1 0 109.49 17.4495 17.4015 17.4908 15.0752 15.3442 14.3782 16.8234 16.9818 17.0065 16.036 15.6208 16.0845 P62820 RAB1A_HUMAN Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) RAB1A RAB1 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell migration [GO:0016477]; COPII-coated vesicle cargo loading [GO:0090110]; defense response to bacterium [GO:0042742]; endocytosis [GO:0006897]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; growth hormone secretion [GO:0030252]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; positive regulation of glycoprotein metabolic process [GO:1903020]; positive regulation of interleukin-8 production [GO:0032757]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle transport along microtubule [GO:0047496]; vesicle-mediated transport [GO:0016192]; virion assembly [GO:0019068] cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; transport vesicle membrane [GO:0030658] cadherin binding [GO:0045296]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EFADSLGIPFLETSAK;IQSTPVK;LLLIGDSGVGK;MGPGATAGGAEK;NATNVEQSFMTMAAEIK;QSGGGCC;TIELDGK;TITSSYYR 8 41.5 0 4.413 0 10.1971 8.181 0 0 7.3779 0 10.6951 0 0 10.2871 9.7398 P62826 RAN_HUMAN GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) RAN ARA24 OK/SW-cl.81 Homo sapiens (Human) cell division [GO:0051301]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; snRNA import into nucleus [GO:0061015]; viral process [GO:0016032] centriole [GO:0005814]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565] cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] AAQGEPQVQFK;FNVWDTAGQEK;GPIKFNVWDTAGQEK;HLTGEFEK;LVLVGDGGTGK;NLQYYDISAK;SIVFHRKK;VTYKNVPNWHR 8 34.3 0 45.223 13.7333 14.7941 14.5256 15.2309 0 11.9296 14.1819 13.9669 13.6266 13.6348 14.3509 12.2357 P62829 RL23_HUMAN Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) RPL23 Homo sapiens (Human) cellular response to actinomycin D [GO:0072717]; cytoplasmic translation [GO:0002181]; G1 to G0 transition [GO:0070314]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein stabilization [GO:0050821]; protein-DNA complex disassembly [GO:0032986]; regulation of G1 to G0 transition [GO:1903450]; ribosomal protein import into nucleus [GO:0006610]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; synapse [GO:0045202] large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; transcription coactivator binding [GO:0001223]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] GGSSGAK;GSAITGPVAK;ISLGLPVGAVINCADNTGAK;LPAAGVGDMVMATVK 4 37.1 0.9455 -0.6431 11.9398 8.63147 0 0 1.56145 0 0 6.96798 9.26831 0 0 10.7805 P62841 RS15_HUMAN Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (RIG protein) RPS15 RIG Homo sapiens (Human) cytoplasmic translation [GO:0002181]; osteoblast differentiation [GO:0001649]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] AEVEQKK 1 4.8 0.42311 0.19762 0 0 0 0 0 0 0 0 0 8.97905 0 0 P62847 RS24_HUMAN Small ribosomal subunit protein eS24 (40S ribosomal protein S24) RPS24 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369] ANVGAGK;MNDTVTIR;TTPDVIFVFGFR 3 20.3 0 2.9142 10.7707 11.0101 9.89418 0 10.343 9.94917 10.7951 10.0419 11.1979 9.18661 0 0 P62851 RS25_HUMAN Small ribosomal subunit protein eS25 (40S ribosomal protein S25) RPS25 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AALQELLSK;AQVIYTR;GGDAPAAGEDA;LITPAVVSER 4 29.6 0 7.777 13.4729 12.4952 12.9976 9.73606 9.24608 9.53312 12.4087 10.5735 12.4593 12.6489 12.7034 11.4187 P62854 RS26_HUMAN Small ribosomal subunit protein eS26 (40S ribosomal protein S26) RPS26 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DISEASVFDAYVLPK;NIVEAAAVR 2 20.9 0 6.2713 11.8145 11.674 0 0 7.62571 8.77998 10.168 11.1979 10.9917 9.14343 8.85315 10.9669 P62857 RS28_HUMAN Small ribosomal subunit protein eS28 (40S ribosomal protein S28) RPS28 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EGDVLTLLESER;VEFMDDTSR 2 30.4 0 2.3796 10.9292 0 0 0 0 8.84068 0 0 0 11.2902 9.23477 0 P62861 RS30_HUMAN Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (FAU ubiquitin like and ribosomal protein S30 fusion) [Cleaved into: Ubiquitin-like protein FUBI; Small ribosomal subunit protein eS30 (40S ribosomal protein S30)] FAU Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FVNVVPTFGK 1 7.5 0.013917 0.81297 0 13.0235 12.7668 4.32661 10.0176 0 12.6245 0 0 0 0 11.6279 P62888 RL30_HUMAN Large ribosomal subunit protein eL30 (60S ribosomal protein L30) RPL30 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] SLESINSR;TGVHHYSGNNIELGTACGKYYR 2 26.1 0.91526 -0.37735 0 0 0 11.2171 0 0 0 0 0 11.6152 8.34163 0 P62891 RL39_HUMAN Large ribosomal subunit protein eL39 (60S ribosomal protein L39) RPL39 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular space [GO:0005615] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] QKQNRPIPQWIR 1 23.5 0.95222 -0.70755 0 0 0 0 0 0 0 0 0 9.75298 0 0 P62899 RL31_HUMAN Large ribosomal subunit protein eL31 (60S ribosomal protein L31) RPL31 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EMGTPDVR;EYTINIHK;NLQTVNVDEN 3 20.8 0 53.991 9.67152 8.44634 8.6691 5.91193 0 0 11.0278 0 9.89933 0 11.4519 0 P62906 RL10A_HUMAN Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) RPL10A NEDD6 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; response to ethanol [GO:0045471]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DTLYEAVR;ILGPGLNK 2 7.4 0 1.9802 9.6162 10.9855 12.233 0 0 0 13.3257 9.47338 0 10.2588 11.8606 0 P62910 RL32_HUMAN Large ribosomal subunit protein eL32 (60S ribosomal protein L32) RPL32 PP9932 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AAQLAIR 1 5.2 0.050523 0.48209 0 0 0 0 0 0 0 0 0 10.3439 9.61137 0 P62913 RL11_HUMAN Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) RPL11 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of protein binding [GO:0032092]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] AEEILEK;AQDQGEKENPMR;ISKEEAMR;TGCIGAK;VLEQLTGQTPVFSK;YDGIILPGK 6 32 0 4.8113 13.8231 12.8966 12.3197 11.9952 0 0 8.96119 11.804 14.1625 11.982 10.3316 12.9632 P62917 RL8_HUMAN Large ribosomal subunit protein uL2 (60S ribosomal protein L8) RPL8 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] ASGNYATVISHNPETK;AVDFAER;AVVGVVAGGGR;DIIHDPGR;IDKPILK;VGLIAAR 6 21.8 0 8.5329 12.5719 0 12.6502 10.0414 0 0 10.9506 11.2841 11.3537 10.966 0 9.84147 P62937 PPIA_HUMAN "Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]" PPIA CYPA Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; apoptotic process [GO:0006915]; cell adhesion molecule production [GO:0060352]; cellular response to oxidative stress [GO:0034599]; endothelial cell activation [GO:0042118]; leukocyte chemotaxis [GO:0030595]; lipid droplet organization [GO:0034389]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of viral life cycle [GO:1903901]; neuron differentiation [GO:0030182]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of viral genome replication [GO:0045069]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] cyclosporin A binding [GO:0016018]; heparan sulfate binding [GO:1904399]; integrin binding [GO:0005178]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790] ALSTGEK;EGMNIVEAMER;FEDENFILK;HNGTGGK;ITIADCGQLE;MVNPTVFFDIAVDGEPLGR;NGKTSKK;SIYGEKFEDENFILK;TEWLDGK;VKEGMNIVEAMER;VNPTVFFDIAVDGEPLGR;VPKTAENFR;VSFELFADK;VSFELFADKVPK 14 62.4 0 87.633 13.8966 12.9636 13.1774 10.8985 10.7379 10.3912 13.9174 14.5623 14.2284 13.1094 13.3215 14.1345 P62942 FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) FKBP1A FKBP1 FKBP12 Homo sapiens (Human) 'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein binding [GO:0032092]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; supramolecular fiber organization [GO:0097435]; T cell activation [GO:0042110]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; membrane [GO:0016020]; ryanodine receptor complex [GO:1990425]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; terminal cisterna [GO:0014802]; Z disc [GO:0030018] activin receptor binding [GO:0070697]; channel regulator activity [GO:0016247]; FK506 binding [GO:0005528]; I-SMAD binding [GO:0070411]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; signaling receptor inhibitor activity [GO:0030547]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane transporter binding [GO:0044325]; type I transforming growth factor beta receptor binding [GO:0034713] GVQVETISPGDGR 1 12 0 2.3193 11.0532 11.0611 0 0 0 0 0 0 8.451 10.8945 11.063 8.83958 P62987 RL40_HUMAN Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] UBA52 UBCEP2 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] EGIPPDQQR;ESTLHLVLR;IQDKEGIPPDQQR;QLAQKYNCDK;TITLEVEPSDTIENVK;TLSDYNIQK;YNCDKMICRK 7 48.4 0 79.365 16.1465 15.6352 15.0975 12.5855 12.5889 12.4019 11.2555 14.7803 14.4424 15.0159 14.6842 13.8961 P62995 TRA2B_HUMAN "Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)" TRA2B SFRS10 Homo sapiens (Human) "cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375]" nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] AAQDRDQIYR;DYYSRSYR;MSDSGEQNYGER;SKEDSRR 4 12.8 0.95512 -0.78926 9.86762 0 9.87186 0 0 0 0 7.97062 0 0 0 4.02228 P63000 RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) RAC1 TC25 MIG5 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; cortical cytoskeleton organization [GO:0030865]; establishment or maintenance of cell polarity [GO:0007163]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; motor neuron axon guidance [GO:0008045]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of receptor-mediated endocytosis [GO:0048261]; neuron migration [GO:0001764]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of lamellipodium assembly [GO:0010591]; regulation of neutrophil migration [GO:1902622]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of respiratory burst [GO:0060263]; regulation of stress fiber assembly [GO:0051492]; respiratory burst [GO:0045730]; response to wounding [GO:0009611]; ruffle assembly [GO:0097178]; ruffle organization [GO:0031529]; semaphorin-plexin signaling pathway [GO:0071526]; small GTPase-mediated signal transduction [GO:0007264]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802] enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; Rho GDP-dissociation inhibitor binding [GO:0051022]; thioesterase binding [GO:0031996] DDKDTIEK;LTPITYPQGLAMAK 2 11.5 0.82971 -0.02245 0 0 0 0 0 0 0 0 0 8.50387 9.11647 0 P63010 AP2B1_HUMAN AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) AP2B1 ADTB2 CLAPB1 Homo sapiens (Human) aorta development [GO:0035904]; clathrin-dependent endocytosis [GO:0072583]; coronary vasculature development [GO:0060976]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; ventricular septum development [GO:0003281]; vesicle-mediated transport [GO:0016192] AP-2 adaptor complex [GO:0030122]; clathrin adaptor complex [GO:0030131]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] clathrin binding [GO:0030276]; signal sequence binding [GO:0005048] DEDPYVRKTAAVCVAK;GLEISGTFTHR;NSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMK;VLMKFLELLPK 4 8 0.97857 -1.9848 9.12441 0 9.85128 0 0 0 8.87098 10.7004 10.7616 11.4324 11.1504 0 P63092 GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) GNAS GNAS1 GSP Homo sapiens (Human) activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to glucagon stimulus [GO:0071377]; cellular response to prostaglandin E stimulus [GO:0071380]; cognition [GO:0050890]; developmental growth [GO:0048589]; G protein-coupled receptor signaling pathway [GO:0007186]; hair follicle placode formation [GO:0060789]; intracellular transport [GO:0046907]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of insulin secretion [GO:0050796]; renal water homeostasis [GO:0003091]; sensory perception of smell [GO:0007608] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] adenylate cyclase activator activity [GO:0010856]; D1 dopamine receptor binding [GO:0031748]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] DIIQRMHLR;ILHVNGFNGDEK;ISTASGDGR;LLLLGAGESGK;TISVILFLNKQDLLAEK 5 15.3 0.085271 0.38166 0 7.80781 0 3.49953 0 0 15.1327 11.6375 8.93227 10.2923 0 11.4886 P63096 GNAI1_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) GNAI1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell division [GO:0051301]; cellular response to forskolin [GO:1904322]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of protein localization to cell cortex [GO:1904778]; regulation of mitotic spindle organization [GO:0060236]; response to peptide hormone [GO:0043434]; response to prostaglandin E [GO:0034695]; T cell migration [GO:0072678] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] adenylate cyclase regulator activity [GO:0010854]; D2 dopamine receptor binding [GO:0031749]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287] LLLLGAGESGK;LWKDSGVQACFNR;RLWKDSGVQACFNR 3 7.1 0.90301 -0.26706 0 6.79675 0 6.82782 0 0 0 0 0 0 0 0 P63104 1433Z_HUMAN 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) YWHAZ Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to glucose starvation [GO:0042149]; ERK1 and ERK2 cascade [GO:0070371]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; lung development [GO:0030324]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; protein targeting [GO:0006605]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; respiratory system process [GO:0003016]; signal transduction [GO:0007165]; synaptic target recognition [GO:0008039]; tube formation [GO:0035148] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; vesicle [GO:0031982] cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] DSTLIMQLLR;FLIPNASQAESK;LAEQAER;MDKNELVQK;NLLSVAYK;SVTEQGAELSNEER;SVTEQGAELSNEERNLLSVAYKNVVGAR;VVSSIEQK;YDDMAACMK;YLAEVAAGDDK;YLAEVAAGDDKK 11 38.8 0 11.099 14.0875 12.2035 10.7576 0 10.0783 0 10.0743 9.11684 0 13.1097 12.8579 7.46385 P63128 POK9_HUMAN Endogenous retrovirus group K member 9 Pol protein (HERV-K(C6) Gag-Pol protein) (HERV-K109 Gag-Pol protein) (HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein) [Includes: Protease (EC 3.4.23.50) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT)] ERVK-9 Homo sapiens (Human) proteolysis [GO:0006508]; viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] aspartic-type endopeptidase activity [GO:0004190]; DNA-directed DNA polymerase activity [GO:0003887]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; telomerase activity [GO:0003720]; zinc ion binding [GO:0008270] APYPQPPTRRLNPTAPPSR;ELKQAGRK;TLLDSIAHGHR 3 3.4 0.98137 -1.7726 0 11.6224 0 0 0 0 12.1475 0 0 0 7.12794 0 P63135 POK7_HUMAN Endogenous retrovirus group K member 7 Pol protein (HERV-K(III) Pol protein) (HERV-K102 Pol protein) (HERV-K_1q22 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)] ERVK-7 Homo sapiens (Human) DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261] DNA binding [GO:0003677]; RNA stem-loop binding [GO:0035613]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; telomerase activity [GO:0003720]; zinc ion binding [GO:0008270] DNKNKTWEIGK;EDNLTLDISK;LANQINDLR 3 2.1 0.97711 -1.4919 0 0 0 0 0 0 0 0 0 8.38176 0 0 P63145 GAK24_HUMAN Endogenous retrovirus group K member 24 Gag polyprotein (HERV-K101 Gag protein) (HERV-K_22q11.21 provirus ancestral Gag polyprotein) (Gag polyprotein) ERVK-24 Homo sapiens (Human) viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] APYPQPPTRRLNPTAPPSR;ELKQAGRK;IQDPGSACPSFNTVR 3 6.3 0.84962 -0.07636 8.78813 0 8.38249 0 0 0 0 0 0 0 0 0 P63173 RL38_HUMAN Large ribosomal subunit protein eL38 (60S ribosomal protein L38) RPL38 Homo sapiens (Human) 90S preribosome assembly [GO:0034463]; axial mesoderm development [GO:0048318]; cytoplasmic translation [GO:0002181]; middle ear morphogenesis [GO:0042474]; ossification [GO:0001503]; protein-RNA complex assembly [GO:0022618]; regulation of translation [GO:0006417]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; eukaryotic 80S initiation complex [GO:0033291]; focal adhesion [GO:0005925]; postsynaptic density [GO:0014069] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] QSLPPGLAVK 1 14.3 0 2.2788 11.0808 0 11.474 0 0 0 10.1887 10.6824 9.98499 10.8345 10.7395 0 P63208 SKP1_HUMAN S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1) SKP1 EMC19 OCP2 SKP1A TCEB1L Homo sapiens (Human) chromatin remodeling [GO:0006338]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; SCF ubiquitin ligase complex [GO:0019005] beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; F-box domain binding [GO:1990444]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DDPPPPEDDENKEK;EKRTDDIPVWDQEFLK;GKTPEEIR;NDFTEEEEAQVR;TDDIPVWDQEFLK;TVANMIK 6 33.7 0.71523 0.14013 0 0 0 0 0 0 4.61706 0 9.60047 10.6067 12.8965 0 P63220 RS21_HUMAN Small ribosomal subunit protein eS21 (40S ribosomal protein S21) RPS21 Homo sapiens (Human) "cytoplasmic translation [GO:0002181]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] MGESDDSILR;MQNDAGEFVDLYVPR;VTGRFNGQFK 3 42.2 0 13.422 0 0 0 8.42358 8.79201 8.42585 0 0 0 11.4718 9.5808 11.732 P63241 IF5A1_HUMAN Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) EIF5A Homo sapiens (Human) cellular response to virus [GO:0098586]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]; tumor necrosis factor-mediated signaling pathway [GO:0033209] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U6 snRNA binding [GO:0017070] IVEMSTSK;IVEMSTSKTGK;NGFVVLK 3 11.7 0.95549 -0.93617 0 0 9.6365 0 0 0 0 0 0 14.0215 9.53475 0 P63244 RACK1_HUMAN "Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]" RACK1 GNB2L1 HLC7 PIG21 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cytoplasmic translation [GO:0002181]; gastrulation [GO:0007369]; negative regulation of cell growth [GO:0030308]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein binding [GO:0032091]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of translation [GO:0017148]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of Wnt signaling pathway [GO:0030178]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; protein ubiquitination [GO:0016567]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; IRE1-RACK1-PP2A complex [GO:1990630]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; small ribosomal subunit [GO:0015935] BH3 domain binding [GO:0051434]; cadherin binding [GO:0045296]; cyclin binding [GO:0030332]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ion channel inhibitor activity [GO:0008200]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase inhibitor activity [GO:0030292]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; translation regulator activity [GO:0045182] DETNYGIPQR;DGQAMLWDLNEGK;DVLSVAFSSDNR;LTRDETNYGIPQRALR;LWDLTTGTTTR;QIVSGSR;TEQMTLR;VWQVTIGTR 8 23.7 0 7.1368 0 0 10.8844 9.36407 0 0 9.11673 11.8792 11.4303 10.3378 11.5706 9.3267 P63272 SPT4H_HUMAN Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit) SUPT4H1 SPT4H SUPT4H Homo sapiens (Human) "negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]" DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein heterodimerization activity [GO:0046982]; RNA polymerase II complex binding [GO:0000993]; zinc ion binding [GO:0008270] GVAYKSR 1 6 0.97785 -1.5066 11.6235 0 0 0 0 0 0 0 0 0 12.2983 0 P63313 TYB10_HUMAN Thymosin beta-10 TMSB10 PTMB10 THYB10 Homo sapiens (Human) actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin monomer binding [GO:0003785] ADKPDMGEIASFDK;ETIEQEK 2 47.7 0 8.7587 12.4378 12.7745 12.9048 8.88969 8.88499 8.97327 8.89724 11.1584 11.1358 10.3849 0 0 P63316 TNNC1_HUMAN "Troponin C, slow skeletal and cardiac muscles (TN-C)" TNNC1 TNNC Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; regulation of ATP-dependent activity [GO:0043462]; regulation of muscle contraction [GO:0006937]; regulation of muscle filament sliding speed [GO:0032972]; response to metal ion [GO:0010038]; skeletal muscle contraction [GO:0003009]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; troponin complex [GO:0005861] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; troponin I binding [GO:0031013]; troponin T binding [GO:0031014] IDYDEFLEFMK 1 6.8 0.94073 -0.60881 0 0 0 0 0 0 7.2737 0 0 0 0 0 P67809 YBOX1_HUMAN Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) YBX1 NSEP1 YB1 Homo sapiens (Human) "cellular response to interleukin-7 [GO:0098761]; CRD-mediated mRNA stabilization [GO:0070934]; embryonic morphogenesis [GO:0048598]; epidermis development [GO:0008544]; in utero embryonic development [GO:0001701]; miRNA transport [GO:1990428]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cellular senescence [GO:2000773]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of cell division [GO:0051781]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]; tRNA transport [GO:0051031]" CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; U12-type spliceosomal complex [GO:0005689] C5-methylcytidine-containing RNA reader activity [GO:0062153]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697] AADPPAENSSAPEAEQGGAE;GAEAANVTGPGGVPVQGSK;NGYGFINR;SVGDGETVEFDVVEGEK 4 19.8 0 20.994 9.8757 11.204 10.9125 0 7.57901 0 10.3765 10.2584 8.12257 11.2669 0 0 P67812 SC11A_HUMAN Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) SEC11A SEC11L1 SPC18 SPCS4A Homo sapiens (Human) response to virus [GO:0009615]; signal peptide processing [GO:0006465] endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GFYQENSSVEDR;LSLDFLDDVRR 2 14 0.87886 -0.14215 0 0 0 0 0 9.83878 0 0 0 0 0 0 P67936 TPM4_HUMAN Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) TPM4 Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; osteoblast differentiation [GO:0001649]; platelet formation [GO:0030220] actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; muscle thin filament tropomyosin [GO:0005862]; podosome [GO:0002102]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] AEGDVAALNR;AEVSELK;AGLNSLEAVK;EAETRAEFAER;EAKHIAEEADRK;HIAEEADR;IQLVEEELDR;LATALQK;SLEAASEK;TIDDLEEK 10 33.5 0 11.324 12.2669 11.8438 0 0 0 0 0 11.7545 0 11.5504 10.3378 0 P68104 EF1A1_HUMAN Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) EEF1A1 EEF1A EF1A LENG7 Homo sapiens (Human) cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation by host of viral genome replication [GO:0044829]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414] cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; eukaryotic translation elongation factor 1 complex [GO:0005853]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774] calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase activator activity [GO:0019209]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049] EAAEMGK;EHALLAYTLGVK;EVSTYIK;EVSTYIKK;IGGIGTVPVGR;KAAGAGK;KLEDGPK;LKAERER;LPLQDVYK;QLIVGVNK;QTVAVGVIK;STTTGHLIYK;THINIVVIGHVDSGK;TIEKFEK;VETGVLKPGMVVTFAPVNVTTEVK;YEEIVKEVSTYIK 16 31.6 0 109.8 18.154 18.5188 18.5591 15.428 16.161 14.7542 16.4242 16.6076 17.787 15.8257 15.9086 15.1476 P68133 ACTS_HUMAN "Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]" ACTA1 ACTA Homo sapiens (Human) cellular response to potassium ion [GO:0035865]; mesenchyme migration [GO:0090131]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; response to mechanical stimulus [GO:0009612]; response to steroid hormone [GO:0048545]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; blood microparticle [GO:0072562]; cell body [GO:0044297]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865] ADP binding [GO:0043531]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; myosin binding [GO:0017022]; structural constituent of cytoskeleton [GO:0005200] AGFAGDDAPR;AVFPSIVGRPR;CDIDIRK;DLTDYLMK;DSYVGDEAQSK;DSYVGDEAQSKR;EITALAPSTMK;HQGVMVGMGQK;IIAPPER;IIAPPERK;IKIIAPPER;LDLAGRDLTDYLMK;MQKEITALAPSTMK;SYELPDGQVITIGNER 14 27.9 0.8124 0.0022352 0 0 0 0 0 0 0 0 12.8298 0 0 0 P68363 TBA1B_HUMAN Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] TUBA1B Homo sapiens (Human) cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] AVCMLSNTTAIAEAWAR;AVFVDLEPTVIDEVR;DVNAAIATIK;EDAANNYAR;EDMAALEK;EIIDLVLDR;FDGALNVDLTEFQTNLVPYPR;FDLMYAK;GHYTIGK;IHFPLATYAPVISAEK;LISQIVSSITASLR;LSVDYGK;LSVDYGKK;NLDIERPTYTNLNR;SIQFVDWCPTGFK;TIGGGDDSFNTFFSETGAGK;VGINYQPPTVVPGGDLAK;YMACCLLYR 18 47.7 0 212.53 17.0934 17.034 17.2492 14.0103 14.4314 13.9206 14.5012 16.1963 16.2807 15.3039 15.6124 16.0405 P68366 TBA4A_HUMAN Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) TUBA4A TUBA1 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200] AVCMLSNTTAIAEAWAR;DVNAAIAAIK;EDAANNYAR;EDMAALEK;EIIDPVLDR;FDGALNVDLTEFQTNLVPYPR;FDLMYAK;GHYTIGK;IHFPLATYAPVISAEK;LISQIVSSITASLR;LSVDYGK;LSVDYGKK;NLDIERPTYTNLNR;SIQFVDWCPTGFK;VGINYQPPTVVPGGDLAK;YMACCLLYR 16 40.2 0 2.4537 0 0 0 0 0 0 9.71394 0 9.84134 0 0 10.944 P68371 TBB4B_HUMAN Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) TUBB4B TUBB2C Homo sapiens (Human) flagellated sperm motility [GO:0030317]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267] axonemal microtubule [GO:0005879]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; structural constituent of cytoskeleton [GO:0005200]; unfolded protein binding [GO:0051082] ALTVPELTQQMFDAK;AVLVDLEPGTMDSVR;EVDEQMLNVQNK;FPGQLNADLRK;GHYTEGAELVDSVLDVVR;IMNTFSVVPSPK;INVYYNEATGGK;INVYYNEATGGKYVPR;IREEYPDR;IREEYPDRIMNTFSVVPSPK;ISEQFTAMFR;LAVNMVPFPR;LHFFMPGFAPLTSR;MSATFIGNSTAIQELFKR;NSSYFVEWIPNNVK;SGPFGQIFRPDNFVFGQSGAGNNWAK;TAVCDIPPR;YLTVAAVFR 18 48.8 0 150.48 16.9631 16.4207 16.6974 14.1298 14.5195 14.5411 15.9989 16.181 16.4046 15.2589 14.8929 16.0066 P68400 CSK21_HUMAN Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 CK2A1 Homo sapiens (Human) apoptotic process [GO:0006915]; chaperone-mediated protein folding [GO:0061077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of translation [GO:0017148]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of aggrephagy [GO:1905337]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of chromosome separation [GO:1905818]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; symbiont-mediated disruption of host cell PML body [GO:0075342]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; Sin3-type complex [GO:0070822] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIKILENLRGGPNIITLADIVK;ILKPVKKK;VVVKILKPVK;VVVKILKPVKK 4 8.7 0.96349 -1.1104 0 0 0 8.63434 0 0 0 0 0 0 0 0 P68431 H31_HUMAN Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J Homo sapiens (Human) chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; gene expression [GO:0010467]; nucleosome assembly [GO:0006334]; telomere organization [GO:0032200] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] EIAQDFK;EIAQDFKTDLR;RVTIMPK;SAPATGGVK;STELLIR;YQKSTELLIR;YRPGTVALR 7 33.8 0 15.617 16.0412 16.5103 15.9644 13.2486 12.8959 12.8776 15.84 16.0768 15.7149 15.0225 13.8774 14.9467 P69892 HBG2_HUMAN Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) HBG2 Homo sapiens (Human) carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] GTFAQLSELHCDK;LLVVYPWTQR 2 15.6 0.89737 -0.23401 0 0 0 0 0 0 0 0 0 10.3133 0 0 P69905 HBA_HUMAN Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] HBA1; HBA2 Homo sapiens (Human) carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; response to hydrogen peroxide [GO:0042542] blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; membrane [GO:0016020] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] MFLSFPTTK;VDPVNFK;VGAHAGEYGAEALER;VLSPADKTNVK 4 29.6 0 6.7851 14.7999 14.9249 13.5015 10.6566 8.28151 10.582 13.2191 13.3641 13.4329 13.3016 13.0833 0 P78310 CXAR_HUMAN Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) CXADR CAR Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; AV node cell to bundle of His cell communication [GO:0086067]; AV node cell-bundle of His cell adhesion involved in cell communication [GO:0086072]; cardiac muscle cell development [GO:0055013]; cell-cell junction organization [GO:0045216]; defense response to virus [GO:0051607]; epithelial structure maintenance [GO:0010669]; gamma-delta T cell activation [GO:0046629]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homotypic cell-cell adhesion [GO:0034109]; mitochondrion organization [GO:0007005]; neutrophil chemotaxis [GO:0030593]; regulation of AV node cell action potential [GO:0098904]; transepithelial transport [GO:0070633] acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] beta-catenin binding [GO:0008013]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in AV node cell-bundle of His cell communication [GO:0086082]; connexin binding [GO:0071253]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] EDVPPPK 1 1.9 0.68127 0.16457 0 0 0 0 0 0 0 0 0 6.42797 0 0 P78312 F193A_HUMAN Protein FAM193A (Protein IT14) FAM193A C4orf8 RES4-22 Homo sapiens (Human) GAAMTMK;GAAMTMKTKQR;KCLYNFQDAFMEANK;REEEEDEEEEEDR;SPRTEESK 5 3.8 0.96447 -1.1747 8.75822 0 6.68018 0 0 0 0 0 12.5025 0 7.65206 0 P78314 3BP2_HUMAN SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) signal transduction [GO:0007165] phosphotyrosine residue binding [GO:0001784]; SH3 domain binding [GO:0017124] VPATPRR 1 1.2 0.78282 0.024506 0 0 0 0 0 7.31542 0 0 0 0 0 0 P78316 NOP14_HUMAN Nucleolar protein 14 (Nucleolar complex protein 14) NOP14 C4orf9 NOL14 RES4-25 Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" 90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515] ELIEELIAK 1 1.1 0.90898 -0.31376 0 12.4716 0 0 0 6.95163 6.61853 0 0 0 0 0 P78318 IGBP1_HUMAN Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) IGBP1 IBP1 Homo sapiens (Human) B cell activation [GO:0042113]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of dephosphorylation [GO:0035303]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888] LSAMKSAVESGQADDERVR 1 5.6 0.84778 -0.071554 0 0 0 0 0 0 0 0 0 0 0 8.51373 P78324 SHPS1_HUMAN Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; monocyte extravasation [GO:0035696]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of JNK cascade [GO:0046329]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of T cell activation [GO:0050870]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] cell-cell adhesion mediator activity [GO:0098632]; GTPase regulator activity [GO:0030695]; protein antigen binding [GO:1990405]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein tyrosine kinase binding [GO:1990782]; SH3 domain binding [GO:0017124] GAGPGRELIYNQK;GTANLSETIR;KAQGSTSSTRLHEPEK 3 7.7 0.8407 -0.046466 9.83838 0 0 0 0 0 0 10.1022 0 8.52223 0 0 P78325 ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) ADAM8 MS2 Homo sapiens (Human) angiogenesis [GO:0001525]; canonical NF-kappaB signal transduction [GO:0007249]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; extracellular matrix disassembly [GO:0022617]; inflammatory response [GO:0006954]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibronectin-dependent thymocyte migration [GO:2000415]; positive regulation of innate immune response [GO:0045089]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein processing [GO:0010954]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; proteolysis [GO:0006508]; regulation of cell-cell adhesion [GO:0022407]; signal release [GO:0023061] alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dense core granule membrane [GO:0032127]; ficolin-1-rich granule membrane [GO:0101003]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; podosome [GO:0002102]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; tertiary granule [GO:0070820]; tertiary granule membrane [GO:0070821] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; immunoglobulin receptor binding [GO:0034987]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor receptor superfamily binding [GO:0032813]; zinc ion binding [GO:0008270] DMCDLEEFCDGR;NRCCNSTTCQLAEGAQCAHGTCCQECK;VALKPPIQR 3 5.8 0.96505 -1.1358 0 6.40905 10.1875 0 0 0 0 0 0 0 0 0 P78325 ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) ADAM8 MS2 Homo sapiens (Human) angiogenesis [GO:0001525]; canonical NF-kappaB signal transduction [GO:0007249]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; extracellular matrix disassembly [GO:0022617]; inflammatory response [GO:0006954]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibronectin-dependent thymocyte migration [GO:2000415]; positive regulation of innate immune response [GO:0045089]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein processing [GO:0010954]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; proteolysis [GO:0006508]; regulation of cell-cell adhesion [GO:0022407]; signal release [GO:0023061] alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dense core granule membrane [GO:0032127]; ficolin-1-rich granule membrane [GO:0101003]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; podosome [GO:0002102]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; tertiary granule [GO:0070820]; tertiary granule membrane [GO:0070821] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; immunoglobulin receptor binding [GO:0034987]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor receptor superfamily binding [GO:0032813]; zinc ion binding [GO:0008270] DMCDLEEFCDGR;LLTEVHAGCQPR;NRCCNSTTCQLAEGAQCAHGTCCQECK 3 6.9 0.87286 -0.10837 0 0 0 0 0 9.11377 0 0 0 0 0 0 P78329 CP4F2_HUMAN Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78) CYP4F2 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; blood coagulation [GO:0007596]; epoxygenase P450 pathway [GO:0019373]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; alkane 1-monooxygenase activity [GO:0018685]; alpha-tocopherol omega-hydroxylase activity [GO:0052871]; arachidonate epoxygenase activity [GO:0008392]; arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" CFPQPPR;IFNESVNIMHAK 2 3.7 0.92728 -0.45655 7.94574 0 0 0 0 0 10.5772 0 0 0 0 0 P78332 RBM6_HUMAN RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) RBM6 DEF3 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]" nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] DGTQVDFR;DTPHSDFRGR;EAERYLPPSR;GVTRFQENASEGK;LACLLCRR;NDSGDHSDHMHYYQGKK;QSEQELAYLERRER;TIMLKRIYR 8 7.9 0.97822 -6.9037 0 10.5802 10.506 4.27821 0 10.3917 12.1071 0 11.129 0 9.45855 10.7226 P78333 GPC5_HUMAN Glypican-5 [Cleaved into: Secreted glypican-5] GPC5 Homo sapiens (Human) cell migration [GO:0016477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein localization to membrane [GO:1905475] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DVSPFGNIPQR 1 1.9 0.78719 0.017918 0 0 0 0 4.03192 0 0 0 0 0 0 0 P78334 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon) GABRE Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; negative regulation of chloride transport [GO:2001226]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851] DVVYGPQPQPLENQLLSEETK 1 4.2 0.78106 0.021467 0 0 0 0 0 0 0 0 6.09866 0 0 0 P78344 IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) EIF4G2 DAP5 OK/SW-cl.75 Homo sapiens (Human) cell death [GO:0008219]; heart development [GO:0007507]; macromolecule biosynthetic process [GO:0009059]; negative regulation of autophagy [GO:0010507]; positive regulation of axon extension [GO:0045773]; positive regulation of cell growth [GO:0030307]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of translation [GO:0045727]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] adherens junction [GO:0005912]; axon [GO:0030424]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020] "cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" AFLDNGPKTINQIR;EQLEQEK;FIGELGK;FLLQDTVELR;FSASSGGGGSR;FSPTMGR;HFLPEMLSKVIILSLDRSDEDK;NVDVYDKR 8 9.5 0.97853 -1.9747 0 0 3.68403 0 0 0 7.7862 9.36593 9.15548 7.28031 11.7211 0 P78345 RPP38_HUMAN Ribonuclease P protein subunit p38 (RNaseP protein p38) RPP38 Homo sapiens (Human) rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682] fibrillar center [GO:0001650]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] LIPNPNK;TDAKQQVSGWTPAHVRK 2 8.5 0.9131 -0.38825 0 0 0 0 0 0 11.2052 8.04325 0 0 0 0 P78347 GTF2I_HUMAN General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) GTF2I BAP135 WBSCR6 Homo sapiens (Human) negative regulation of angiogenesis [GO:0016525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" ANELPQPPVPEPANAGK;EQVNDLFSR;FAEALGSTEAK;IIQVGNRIKFVIK;ILDSAEFIK;ITDLRKQVEELFER 6 7.3 0.25578 0.27336 10.2355 11.9716 0 0 0 0 0 6.49198 9.9334 9.22147 0 9.67804 P78348 ASIC1_HUMAN "Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)" ASIC1 ACCN2 BNAC2 Homo sapiens (Human) associative learning [GO:0008306]; behavioral fear response [GO:0001662]; calcium ion transmembrane transport [GO:0070588]; cellular response to pH [GO:0071467]; memory [GO:0007613]; negative regulation of neurotransmitter secretion [GO:0046929]; neurotransmitter secretion [GO:0007269]; protein homotrimerization [GO:0070207]; regulation of membrane potential [GO:0042391]; regulation of postsynapse assembly [GO:0150052]; response to acidic pH [GO:0010447]; response to amphetamine [GO:0001975]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839]; pH-gated monoatomic ion channel activity [GO:0160128] DQEYCVCEMPCNLTR;VVFTRYGK;YEIPDTQMADEK 3 6.6 0.90777 -0.306 0 0 4.57125 0 9.76838 0 0 0 0 5.35406 0 0 P78352 DLG4_HUMAN Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) DLG4 PSD95 Homo sapiens (Human) AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; learning [GO:0007612]; locomotory exploration behavior [GO:0035641]; negative regulation of receptor internalization [GO:0002091]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of synaptic transmission [GO:0050806]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; receptor localization to synapse [GO:0097120]; regulation of grooming behavior [GO:2000821]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synaptic vesicle maturation [GO:0016188]; vocalization behavior [GO:0071625] adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021] acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; D1 dopamine receptor binding [GO:0031748]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; neuroligin family protein binding [GO:0097109]; P2Y1 nucleotide receptor binding [GO:0031812]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110] FIEAGQYNSHLYGTSVQSVR;ITEEQARKAFDR;KGDQILSVNGVDLR 3 6.4 0.73251 0.11218 0 0 9.86067 0 0 0 0 0 0 0 0 10.7632 P78357 CNTP1_HUMAN Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190) CNTNAP1 CASPR NRXN4 Homo sapiens (Human) "axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cytoskeleton organization [GO:0007010]; mitochondrion organization [GO:0007005]; myelination in peripheral nervous system [GO:0022011]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; neuron projection morphogenesis [GO:0048812]; neuronal action potential propagation [GO:0019227]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; postsynaptic density organization [GO:0097106]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]" glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; presynaptic active zone [GO:0048786] SH3 domain binding [GO:0017124]; signaling receptor activity [GO:0038023] GCIENVIFNR;NLFIQVDYFPLTEQK;STSEAQFFLRPLRCYGDR 3 3.1 0.95496 -0.97349 0 0 0 0 0 9.45292 0 0 10.3799 0 0 7.2363 P78362 SRPK2_HUMAN SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] SRPK2 Homo sapiens (Human) "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; R-loop processing [GO:0062176]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] GGYHPVKIGDLFNGR 1 2.2 0.88299 -0.17401 0 0 0 0 10.6838 0 0 0 0 0 0 0 P78363 ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein) ABCA4 ABCR Homo sapiens (Human) "lipid transport [GO:0006869]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; phototransduction, visible light [GO:0007603]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]" cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202] 11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; flippase activity [GO:0140327]; GTPase activity [GO:0003924]; N-retinylidene-phosphatidylethanolamine flippase activity [GO:0140347]; phosphatidylethanolamine flippase activity [GO:0090555]; phospholipid transporter activity [GO:0005548]; retinoid binding [GO:0005501]; retinol transmembrane transporter activity [GO:0034632] AYASLFR;DIFNITDRTLR;STEILQDLTDR 3 1.3 0.96144 -1.0671 0 0 0 0 0 0 6.61442 12.1548 0 0 0 0 P78367 NKX32_HUMAN Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B) NKX3-2 BAPX1 NKX3B Homo sapiens (Human) animal organ formation [GO:0048645]; cell differentiation [GO:0030154]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; intestinal epithelial cell development [GO:0060576]; middle ear morphogenesis [GO:0042474]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; pancreas development [GO:0031016]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SPRTEDDGVGPR 1 3.6 0.92358 -0.44779 0 0 0 0 0 0 0 7.45812 0 0 0 0 P78371 TCPB_HUMAN T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) CCT2 99D8.1 CCTB Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] ASLSLAPVNIFK;DASLMVTNDGATILK;EAESLIAK;EAVAMESYAK;GSGNLEAIHIIK;IGVNQPK;ILLSSGR;LAVEAVLR;LIEEVMIGEDK;LTSFIGAIAIGDLVK;MLPTIIADNAGYDSADLVAQLR;NIGVDNPAAK;VLVDMSR;VQDDEVGDGTTSVTVLAAELLR 14 31 0 84.202 8.94222 13.6495 10.5661 11.223 11.008 10.5419 13.1169 12.6075 12.8545 13.6349 11.8078 11.7457 P78380 OLR1_HUMAN "Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]" OLR1 CLEC8A LOX1 Homo sapiens (Human) blood circulation [GO:0008015]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; lipoprotein metabolic process [GO:0042157]; proteolysis [GO:0006508] extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor activity [GO:0005041] DQPDEKSNGKK;EQMELHHQNLNLQETLKR;LEGQISAR 3 13.6 0.96688 -1.2932 0 0 10.8807 0 0 0 11.1244 0 0 0 0 9.69457 P78382 S35A1_HUMAN CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (CST) (Solute carrier family 35 member A1) SLC35A1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; CMP-N-acetylneuraminate transmembrane transport [GO:0015782]; protein modification process [GO:0036211] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; CMP-N-acetylneuraminate transmembrane transporter activity [GO:0005456] AAPRDNVTLLFK;IPCTALCTVLMLNR;QDTTSIQQGETASK 3 14.4 0.9104 -0.29351 0 0 12.0352 0 0 0 0 0 0 10.0557 0 0 P78383 S35B1_HUMAN Solute carrier family 35 member B1 (ATP/ADP exchanger ER) (AXER) (Endoplasmic reticulum ATP/ADP translocase) (UDP-galactose transporter-related protein 1) (UGTrel1) SLC35B1 UGTREL1 Homo sapiens (Human) UDP-galactose transmembrane transport [GO:0072334] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] ATP:ADP antiporter activity [GO:0005471]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-glucose transmembrane transporter activity [GO:0005460] KYPLAKYLCVLLIVAGVALFMYKPK 1 7 0.66196 0.16893 0 0 0 0 0 6.00789 0 0 0 0 0 0 P78385 KRT83_HUMAN "Keratin, type II cuticular Hb3 (Hair keratin K2.10) (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)" KRT83 KRTHB3 Homo sapiens (Human) epidermis development [GO:0008544]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] FLEQQNK;ILQSHISDTSVVVKLDNSR 2 5.3 0.81271 -0.015664 0 0 0 0 0 0 0 0 0 0 5.33939 0 P78386 KRT85_HUMAN "Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)" KRT85 KRTHB5 Homo sapiens (Human) epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198] ATAENEFVVLK;ATAENEFVVLKK;DLNMDCIIAEIK;FLEQQNK;LLETKWQFYQNQR;MDNSRDLNMDCIIAEIK 6 9.7 0.0025 1.7026 0 0 0 0 0 0 11.9777 10.2802 8.99574 0 12.6213 0 P78406 RAE1L_HUMAN mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) RAE1 MRNP41 Homo sapiens (Human) cell division [GO:0051301]; cellular response to organic cyclic compound [GO:0071407]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; regulation of mitotic spindle organization [GO:0060236]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule binding [GO:0008017]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130] FSFWDKDAR;NAAEELKPR 2 4.9 0.96732 -1.3086 0 0 0 0 0 0 10.4312 0 0 0 0 0 P78411 IRX5_HUMAN Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) IRX5 IRX2A IRXB2 Homo sapiens (Human) cell development [GO:0048468]; embryonic cranial skeleton morphogenesis [GO:0048701]; gonad development [GO:0008406]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; vitamin D binding [GO:0005499]" ENKMTWTPR 1 1.9 0.98088 -1.5759 0 11.0216 0 0 0 0 0 0 0 0 0 0 P78412 IRX6_HUMAN Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) IRX6 IRX7 IRXB3 Homo sapiens (Human) cell development [GO:0048468]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LTMHYPCLEKPR 1 2.7 0.80649 0.012301 4.73742 0 0 0 0 0 0 0 0 0 0 0 P78414 IRX1_HUMAN Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1) IRX1 IRXA1 Homo sapiens (Human) cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gene expression [GO:0010628]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; specification of loop of Henle identity [GO:0072086] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" IDEHDGDQSNEDDEDK 1 3.3 0.64528 0.17154 0 0 0 0 0 0 0 0 8.4824 0 0 0 P78415 IRX3_HUMAN Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3) IRX3 IRXB1 Homo sapiens (Human) atrioventricular bundle cell differentiation [GO:0003167]; cell development [GO:0048468]; energy homeostasis [GO:0097009]; His-Purkinje system cell differentiation [GO:0060932]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Purkinje myocyte development [GO:0003165]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086] axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LVSAPLGK 1 1.6 0.74511 0.10231 10.6043 10.6686 0 0 0 0 0 0 0 11.2132 8.36781 0 P78423 X3CL1_HUMAN Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] CX3CL1 FKN NTT SCYD1 A-152E5.2 Homo sapiens (Human) angiogenesis involved in wound healing [GO:0060055]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; autocrine signaling [GO:0035425]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil chemotaxis [GO:0048245]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin activation [GO:0033622]; leukocyte adhesive activation [GO:0050902]; leukocyte chemotaxis [GO:0030595]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of glutamate receptor signaling pathway [GO:1900450]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron migration [GO:2001223]; negative regulation of tumor necrosis factor production [GO:0032720]; neuron cellular homeostasis [GO:0070050]; neuron remodeling [GO:0016322]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of angiogenesis [GO:0045766]; positive regulation of calcium-independent cell-cell adhesion [GO:0051041]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of neurogenesis [GO:0050767]; regulation of synaptic plasticity [GO:0048167]; response to ischemia [GO:0002931]; synapse pruning [GO:0098883] cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; CXCR1 chemokine receptor binding [GO:0045237]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102] NGGTFEK 1 1.8 0.93018 -0.4766 7.83662 8.8309 0 0 0 0 0 0 0 0 0 0 P78426 NKX61_HUMAN Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A) NKX6-1 NKX6A Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cellular response to cytokine stimulus [GO:0071345]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system neuron differentiation [GO:0021953]; glucose mediated signaling pathway [GO:0010255]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; pancreas development [GO:0031016]; pancreatic A cell differentiation [GO:0003310]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of insulin secretion [GO:0032024]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of axon extension [GO:0030516]; regulation of neuron migration [GO:2001222]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell maturation [GO:0072560]; type B pancreatic cell proliferation [GO:0044342] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ARLAYSLGMTESQVK;TFEQTKYLAGPER 2 7.6 0.95495 -0.87785 0 0 0 0 9.9218 7.28577 0 0 0 0 0 0 P78504 JAG1_HUMAN Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) JAG1 JAGL1 Homo sapiens (Human) angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198] CTRDECDTYFK;DECDTYFK;DECDTYFKVCLK;DSQCDEATCNNGGTCYDEGDAFK;GRSGRPLSLLLALLCALR;LPGDCRCQYGWQGLYCDK;TCMEGWMGPECNR;VTCDDYYYGFGCNKFCRPR 8 8.7 0.97433 -2.4327 4.61753 7.24565 0 6.12274 0 0 0 6.43172 0 6.66633 0 7.15492 P78504 JAG1_HUMAN Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) JAG1 JAGL1 Homo sapiens (Human) angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198] DSQCDEATCNNGGTCYDEGDAFK;INPSRQWQTLK;LPGDCRCQYGWQGLYCDK;TCMEGWMGPECNR;VTCDDYYYGFGCNKFCRPR 5 7.9 0.91603 -0.36506 0 9.49514 0 0 0 0 0 0 0 0 0 0 P78509 RELN_HUMAN Reelin (EC 3.4.21.-) RELN Homo sapiens (Human) "associative learning [GO:0008306]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; cerebral cortex tangential migration [GO:0021800]; dendrite development [GO:0016358]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; NMDA glutamate receptor clustering [GO:0097114]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of lateral motor column neuron migration [GO:1902078]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of TOR signaling [GO:0032008]; postsynaptic density assembly [GO:0097107]; postsynaptic density protein 95 clustering [GO:0097119]; protein localization to synapse [GO:0035418]; proteolysis [GO:0006508]; receptor localization to synapse [GO:0097120]; reelin-mediated signaling pathway [GO:0038026]; regulation of behavior [GO:0050795]; regulation of gene expression [GO:0010468]; regulation of neuron differentiation [GO:0045664]; regulation of neuron migration [GO:2001222]; regulation of NMDA receptor activity [GO:2000310]; regulation of synaptic activity [GO:0060025]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; reelin complex [GO:0110157] lipoprotein particle receptor binding [GO:0070325]; metal ion binding [GO:0046872]; receptor ligand activity [GO:0048018]; serine-type peptidase activity [GO:0008236]; very-low-density lipoprotein particle receptor binding [GO:0070326] GENVQFQWK;GQCTRHGCK;LHLCGSVR;LWQPYNNGKK 4 1 0.97744 -2.1708 0 0 0 8.13894 0 0 0 4.38474 0 8.51688 0 0 P78524 DEN2B_HUMAN DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) DENND2B HTS1 ST5 Homo sapiens (Human) positive regulation of ERK1 and ERK2 cascade [GO:0070374] cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] DENSESESDSDDRFK;GHRKSQSR;LPRLPKR;LVHIQSMLKRAPSYR;SLMESPFPAPGK;TMTANKNSSITHGAGGTK 6 6.6 0.92514 -0.45118 0 0 6.88631 8.53193 3.37058 0 7.28974 5.61903 0 0 6.54882 0 P78527 PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) PRKDC HYRC HYRC1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511] AGSGAGVRCSLLR;AQEPESGLSEETQVK;ATQQQHDFTLTQTADGR;AYVPALQMAFK;DVDFMYVELIQR;DYVAVAR;EIFNFVLK;FLCIFLEK;FLHGKLGNPIVPLNIRLFLAK;FVPLLPGNR;IAPYSVEIK;LACDVDQVTR;LGLPGDEVDNKVK;LGNPIVPLNIR;LLALNSLYSPK;LLEEALLR;LLNTWTNR;LLNTWTNRYPDAK;LLPAELPAK;LLQDFNR;LNESTFDTQITK;LPSNTLDR;LQETLSAADR;LSDFNDITNMLLLK;LSFAVPFR;LSFTRQSFVDR;LSHCRSRSQGCSEQVLTVLK;MAVLALLAK;MSTSPEAFLALR;MYAALGDPK;NKLQYFMEQFYGIIR;QITPQQQEK;RLLNTWTNRYPDAK;RYNFPVEVEVPMERK;SIELFYK;SIELFYKFVPLLPGNRSPNLWLK;SIGEYDVLR;SLGPPQGEEDSVPR;SMEEDPQTSR;STVLTPMFVETQASQGTLQTR;TETVTSFR;TLVECWKDCLSIPYRLIFEK;TQEGSLSAR;TQMTSAVR;TSPQEGERYNYSK;TVGALQVLGTEAQSSLLK;TYSVVPMTSR;VAACELLHSMVMFMLGK;VEFLRNELEIPGQYDGR;VEGMTELYFQLK;VTELALTASDR;VTVMASLRRPKR;VVLKHLK;WKVPTYK;YAVPSAGLR;YFEGVSPK;YNFPVEVEVPMERKK 57 14.8 0.97402 -2.4612 12.7178 12.7935 13.1398 10.1804 11.5065 9.56687 13.9873 14.1721 14.8931 13.69 13.7352 12.0589 P78536 ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) ADAM17 CSVP TACE Homo sapiens (Human) "amyloid precursor protein catabolic process [GO:0042987]; B cell differentiation [GO:0030183]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell motility [GO:0048870]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; commissural neuron axon guidance [GO:0071679]; defense response to Gram-positive bacterium [GO:0050830]; germinal center formation [GO:0002467]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neutrophil mediated immunity [GO:0002446]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of mast cell apoptotic process [GO:0033025]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; signal release [GO:0023061]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; wound healing, spreading of epidermal cells [GO:0035313]" actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; interleukin-6 receptor binding [GO:0005138]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; Notch binding [GO:0005112]; PDZ domain binding [GO:0030165]; peptidase activity [GO:0008233]; SH3 domain binding [GO:0017124]; tumor necrosis factor binding [GO:0043120] EPPEELVHR;EQQLESCACNETDNSCK 2 3.2 0.92941 -0.47408 0 0 0 0 0 0 9.89131 7.19111 0 0 0 0 P78539 SRPX_HUMAN Sushi repeat-containing protein SRPX SRPX ETX1 Homo sapiens (Human) autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] APQGGYYKTALGTRCDIR;GSPAHRPALLLLLPPLLLLLLLR;IGAKIMPPALALQLRLLLR;RCPTLAMPANGGFK;VSWETPEGR;WSDKVICK 6 19.6 0.94428 -0.64747 12.9099 0 5.14551 9.18814 9.81344 5.01605 7.15289 0 0 0 0 0 P78539 SRPX_HUMAN Sushi repeat-containing protein SRPX SRPX ETX1 Homo sapiens (Human) autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] APQGGYYKTALGTRCDIR;GSPAHRPALLLLLPPLLLLLLLR;IGAKIMPPALALQLRLLLR;VICKHMEPPRIK;VSWETPEGR;WSDKVICK 6 21 0.86805 -0.093407 0 0 0 0 0 0 0 0 0 0 10.9533 0 P78540 ARGI2_HUMAN "Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase)" ARG2 Homo sapiens (Human) "adaptive immune response [GO:0002250]; arginine catabolic process to ornithine [GO:0019547]; innate immune response [GO:0045087]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine (C-C motif) ligand 4 production [GO:0071644]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of cellular senescence [GO:2000774]; regulation of interleukin-1 beta production [GO:0032651]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; striated muscle contraction [GO:0006941]; urea cycle [GO:0000050]; ureteric bud development [GO:0001657]" cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] arginase activity [GO:0004053]; manganese ion binding [GO:0030145] MSLRGSLSRLLQTR 1 4 0.56376 0.18264 0 0 0 0 0 0 0 0 0 0 8.36146 0 P78545 ELF3_HUMAN ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) ELF3 ERT ESX JEN Homo sapiens (Human) blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LVYKFGKNSSGWK 1 3.5 0.59958 0.17826 0 0 0 0 0 0 0 8.15451 0 0 0 0 P78549 NTH_HUMAN Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase) NTHL1 NTH1 OCTS3 Homo sapiens (Human) "base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; nucleotide-excision repair [GO:0006289]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]" EEPGPLRR 1 2.6 0.73186 0.11366 0 0 0 0 0 0 0 0 0 0 6.13896 0 P78552 I13R1_HUMAN Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1) IL13RA1 IL13R IL13RA Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of immunoglobulin production [GO:0002639] external side of plasma membrane [GO:0009897]; interleukin-13 receptor complex [GO:0005898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] DSSFEQHSVQIMVK;EMFGDQNDDTLHWKK 2 6.8 0.4276 0.19626 0 6.85848 0 0 0 0 0 0 0 0 7.85705 0 P78559 MAP1A_HUMAN Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] MAP1A MAP1L Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein localization to microtubule [GO:1902817]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to cell surface [GO:2000010]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic plasticity [GO:0048167]; retrograde axonal protein transport [GO:0099642]; voluntary musculoskeletal movement [GO:0050882] axon [GO:0030424]; axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic branch [GO:0044307]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; synapse [GO:0045202] actin binding [GO:0003779]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631] ALGLEESLVQEGRAR;DTALEQKDK;DYRKAEGER;LSKPCCYIFPGGR;SPPCEDFSVTGESEK 5 2.5 0.96632 -1.2833 0 0 2.9622 0 0 0 9.87696 0 6.24125 0 0 0 P78560 CRADD_HUMAN Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) CRADD RAIDD Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634] death domain binding [GO:0070513]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674] MEARDKQVLR 1 5 0.97283 -1.3698 0 11.0865 0 0 0 0 0 0 0 0 0 0 P78562 PHEX_HUMAN Phosphate-regulating neutral endopeptidase PHEX (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP) PHEX PEX Homo sapiens (Human) bone development [GO:0060348]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; lung development [GO:0030324]; odontogenesis [GO:0042476]; organophosphate metabolic process [GO:0019637]; protein modification process [GO:0036211]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to growth hormone [GO:0060416]; response to insulin-like growth factor stimulus [GO:1990418]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DTEAIQK;GTRIALVVFVGGTLVLGTILFLVSQGLLSLQAK;IALVVFVGGTLVLGTILFLVSQGLLSLQAK 3 5.3 0.97899 -1.9026 0 0 0 0 0 0 0 0 0 0 4.38336 0 P78563 RED1_HUMAN Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) ADARB1 ADAR2 DRADA2 RED1 Homo sapiens (Human) adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; defense response to virus [GO:0051607]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innate immune response [GO:0045087]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251] ALRSFVQFPNASEAHLAMGR;ITKPNVYHESK 2 4.2 0.95356 -0.89215 9.01711 0 0 0 0 0 11.653 0 0 0 0 0 P80075 CCL8_HUMAN C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)] CCL8 MCP2 SCYA10 SCYA8 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; eosinophil chemotaxis [GO:0048245]; exocytosis [GO:0006887]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of leukocyte proliferation [GO:0070664]; positive regulation of cell migration [GO:0030335]; positive regulation of leukocyte migration [GO:0002687]; response to virus [GO:0009615]; signal transduction [GO:0007165] extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; heparin binding [GO:0008201]; phospholipase activator activity [GO:0016004]; protein kinase activity [GO:0004672] EVCADPK 1 7.1 0.70424 0.16021 8.31673 8.20423 0 0 0 0 0 0 0 0 0 0 P80192 M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) MAP3K9 MLK1 PRKE1 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] DLKSSNILILQK;ELNIIIHQLCQEKPR;HEIQEMFDQLRAKEK;LKDGNRISLPSDFQHK;SLVDGYK;VGIFPSNYVTPR 6 7 0.96555 -1.2395 10.6909 0 13.2291 9.84735 9.67311 7.13381 0 0 10.0965 0 0 11.6418 P80217 IN35_HUMAN Interferon-induced 35 kDa protein (IFP 35) (Ifi-35) IFI35 IFP35 Homo sapiens (Human) innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] LSEEELLDK 1 3.1 0.90914 -0.31583 0 0 0 0 0 9.87052 0 0 0 0 0 0 P80294 MT1H_HUMAN Metallothionein-1H (MT-1H) (Metallothionein-0) (MT-0) (Metallothionein-IH) (MT-IH) MT1H Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCEAGGSCACAGSCK;DPNCSCEAGGSCACAGSCKCK;DPNCSCEAGGSCACAGSCKCKK;MDPNCSCEAGGSCACAGSCK;MDPNCSCEAGGSCACAGSCKCK;SCCSCCPLGCAK 6 57.4 0.050611 0.4867 0 4.07039 0 7.0027 5.19602 6.65177 0 6.56818 4.461 5.25096 0 0 P80297 MT1X_HUMAN Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX) MT1X Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926]; response to metal ion [GO:0010038] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] CAQGCICKGTSDKCSCCA;GTSDKCSCCA;KSCCSCCPVGCAK;MDPNCSCSPVGSCACAGSCK;SCCSCCPVGCAKCAQGCICK 5 83.6 0.77885 0.034623 0 0 7.50088 0 0 0 3.67412 0 0 0 0 6.59765 P80370 DLK1_HUMAN Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)] DLK1 DLK Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of Notch signaling pathway [GO:0045746] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509] IDMTTFSKEAGDEEI 1 3.9 0.92027 -0.437 0 0 0 0 4.5363 0 0 0 0 0 0 0 P80404 GABT_HUMAN "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid metabolic process [GO:0009448]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; nervous system process [GO:0050877]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410] 4-aminobutyrate transaminase complex [GO:0032144]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] (S)-3-amino-2-methylpropionate transaminase activity [GO:0047298]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; succinate-semialdehyde dehydrogenase binding [GO:0032145] EDLLNNAAHAGK;GVVLGGCGDKSIR;TIFMWYRSK 3 6.8 0.97777 -1.952 8.60777 0 0 0 0 0 0 0 11.0062 0 0 0 P80723 BASP1_HUMAN Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) BASP1 NAP22 Homo sapiens (Human) diaphragm development [GO:0060539]; gonad development [GO:0008406]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchyme development [GO:0072075]; negative regulation of DNA-templated transcription [GO:0045892]; podocyte differentiation [GO:0072112]; positive regulation of heart growth [GO:0060421]; positive regulation of metanephric ureteric bud development [GO:2001076]; protein homooligomerization [GO:0051260]; substantia nigra development [GO:0021762]; supramolecular fiber organization [GO:0097435]; thorax and anterior abdomen determination [GO:0007356] cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; vesicle [GO:0031982] calmodulin binding [GO:0005516]; protein domain specific binding [GO:0019904]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] AAEAAAAPAESAAPAAGEEPSKEEGEPK;AEGAATEEEGTPK;AEPEKTEGAAEAK;AEPPKAPEQEQAAPGPAAGGEAPK;APEQEQAAPGPAAGGEAPK;AQGPAASAEEPKPVEAPAANSDQTVTVKE;EKPDQDAEGKAEEK;ESEPQAAAEPAEAK;ETPAATEAPSSTPK;GGKLSKK;GYNVNDEK;KAEGAATEEEGTPK;KTEAPAAPAAQETK;SDGAPASDSKPGSSEAAPSSK 14 88.1 0 90.236 0 0 0 4.70022 0 0 11.7756 11.7875 11.7571 14.383 14.3946 0 P81133 SIM1_HUMAN Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) SIM1 BHLHE14 Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LIFLDSRVAELTGYEPQDLIEK;LTTSYLK 2 3.8 0.98111 -1.5774 0 0 0 0 0 0 0 0 0 10.3968 0 0 P81172 HEPC_HUMAN Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] HAMP HEPC LEAP1 UNQ487/PRO1003 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; establishment of localization in cell [GO:0051649]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; killing of cells of another organism [GO:0031640]; macrophage activation [GO:0042116]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myeloid cell homeostasis [GO:0002262]; negative regulation of bone resorption [GO:0045779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intestinal absorption [GO:1904479]; negative regulation of iron export across plasma membrane [GO:1904039]; negative regulation of iron ion transmembrane transport [GO:0034760]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of macrophage activation [GO:0043032]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; response to iron ion [GO:0010039]; transcription by RNA polymerase II [GO:0006366] extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] copper ion binding [GO:0005507]; hormone activity [GO:0005179]; transporter regulator activity [GO:0141108] DTHFPICIFCCGCCHRSK 1 21.4 0.82911 -0.023775 0 0 0 0 0 2.90525 0 0 0 0 0 4.83365 P81274 GPSM2_HUMAN G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of centrosome location [GO:0051661]; mitotic spindle organization [GO:0007052]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236] cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; mitotic spindle pole [GO:0097431]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] dynein complex binding [GO:0070840]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904] ASFSNLPGLR;ELNDKVGEAR;HLAIAQELNDR;LLIAKEFGDK;QKPLIAKPSAKLLFVNR 5 8.5 0.95729 -1.027 0 10.3156 0 9.25054 10.263 0 0 0 0 8.94547 0 0 P81277 PRRP_HUMAN Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20] PRLH PRH Homo sapiens (Human) autonomic nervous system development [GO:0048483]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; regulation of multicellular organism growth [GO:0040014]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; response to peptide hormone [GO:0043434]; tissue homeostasis [GO:0001894] extracellular region [GO:0005576] hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; prolactin-releasing peptide receptor binding [GO:0031861] GAASRTHR 1 9.2 0.98075 -1.6156 13.8826 0 0 0 0 0 0 0 0 0 0 0 P81605 DCD_HUMAN Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1] DCD AIDD DSEP Homo sapiens (Human) defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing by host of symbiont cells [GO:0051873]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; peptidase activity [GO:0008233]; RNA binding [GO:0003723] ENAGEDPGLAR 1 10 0.0047281 1.428 0 0 0 0 0 0 0 0 0 11.0806 11.1179 0 P82094 TMF1_HUMAN TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) TMF1 ARA160 Homo sapiens (Human) acrosome assembly [GO:0001675]; androgen receptor signaling pathway [GO:0030521]; defense response to bacterium [GO:0042742]; epithelial cell apoptotic process [GO:1904019]; flagellated sperm motility [GO:0030317]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid nucleus differentiation [GO:0007289] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] DNA binding [GO:0003677]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374] NIKEELATRLNSSETADLLK;QEKDLGRLQVDMDELEEK;SQRPEEEVK 3 4.3 0.93608 -0.55173 0 0 0 0 0 0 0 0 0 5.91598 10.1331 9.87332 P82251 BAT1_HUMAN "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]; protein-containing complex assembly [GO:0065003] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982] LIYVAGR 1 1.4 0.9094 -0.31232 0 0 0 8.88981 0 8.6097 0 0 0 0 0 0 P82279 CRUM1_HUMAN Protein crumbs homolog 1 CRB1 Homo sapiens (Human) blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; cellular response to light stimulus [GO:0071482]; detection of light stimulus involved in visual perception [GO:0050908]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; plasma membrane organization [GO:0007009]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; protein localization [GO:0008104]; retina layer formation [GO:0010842] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003] calcium ion binding [GO:0005509] MALKNINYLLIFYLSFSLLIYIK;QETELNGGFFKGCIQDVR;SNPCHNGGVCHSR 3 3.8 0.83427 -0.029624 0 0 0 0 0 0 0 0 0 0 8.50462 0 P82279 CRUM1_HUMAN Protein crumbs homolog 1 CRB1 Homo sapiens (Human) blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; cellular response to light stimulus [GO:0071482]; detection of light stimulus involved in visual perception [GO:0050908]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; plasma membrane organization [GO:0007009]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; protein localization [GO:0008104]; retina layer formation [GO:0010842] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003] calcium ion binding [GO:0005509] CMCRPGFTGEW;QETELNGGFFKGCIQDVR;SNPCHNGGVCHSR 3 4.5 0.9174 -0.41269 7.82528 0 0 6.47708 6.72833 0 4.42344 0 0 10.1349 10.0558 0 P82650 RT22_HUMAN "Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt)" MRPS22 C3orf5 RPMS22 GK002 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] MIQVYFPK 1 2.2 0.9149 -0.39033 0 0 0 0 0 0 0 0 0 0 0 9.26007 P82663 RT25_HUMAN "Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial) (MRP-S25) (S25mt)" MRPS25 RPMS25 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] NEETLREEEEEKK 1 7.5 0.76723 0.058797 0 0 0 0 0 0 0 0 0 0 6.35177 0 P82663 RT25_HUMAN "Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial) (MRP-S25) (S25mt)" MRPS25 RPMS25 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] SSFLTQPTSALESTACGSASVKWK 1 18.6 0.83666 -0.034544 0 9.61423 0 0 0 0 0 0 0 0 0 0 P82664 RT10_HUMAN "Small ribosomal subunit protein uS10m (28S ribosomal protein S10, mitochondrial) (MRP-S10) (S10mt)" MRPS10 MSTP040 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] TAFGAVCRR 1 4.5 0.91704 -0.36103 0 0 0 0 0 9.69806 0 0 0 11.2203 0 0 P82673 RT35_HUMAN "Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)" MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ESVKRLLNVT;TPGNERPPRRK 2 6.5 0.97625 -1.4664 0 0 0 0 8.37487 0 0 0 0 0 0 0 P82673 RT35_HUMAN "Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)" MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] TPGNERPPRRK;VPFKEAELR 2 10.3 0.93669 -0.52587 0 0 0 0 0 0 0 9.19935 0 0 0 0 P82675 RT05_HUMAN "Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt)" MRPS5 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ILEVFLLGK;LTADELWK;TEQFTICII 3 10.4 0.95173 -0.69494 0 11.3075 0 0 0 0 0 0 0 11.0252 0 0 P82909 KGD4_HUMAN Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) KGD4 MRPS36 DC47 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; tricarboxylic acid cycle [GO:0006099] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] protein-macromolecule adaptor activity [GO:0030674] KLVSQEEMEFIQRGGPE;LVSQEEMEFIQR;TLPQKYRR 3 24.3 0.90929 -0.31357 0 0 3.03684 0 3.98112 0 0 0 7.70086 0 0 0 P82914 RT15_HUMAN "Small ribosomal subunit protein uS15m (28S ribosomal protein S15, mitochondrial) (MRP-S15) (S15mt)" MRPS15 RPMS15 DC37 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AAAAAQKQAK;IVANPEDTRSLEAR;SLEARIIALSVKIR 3 12.8 0.87373 -0.10749 0 10.6727 3.76734 9.52521 0 9.52605 0 0 6.30261 0 0 0 P82930 RT34_HUMAN "Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt)" MRPS34 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] AMIIAERQK;VRALREQLNRPR;VRPRLIAELARR 3 15.1 0.9792 -1.5411 0 10.9748 0 0 0 0 0 6.85362 0 0 0 0 P82932 RT06_HUMAN "Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)" MRPS6 C21orf101 RPMS6 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935] small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] DLENLGER;TIEALMDR 2 12.8 0.95922 -1.0463 0 0 0 0 0 0 0 0 0 6.76487 0 0 P82970 HMGN5_HUMAN High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) HMGN5 NSBP1 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723] EDKNGNEKGEDAK 1 4.6 0.86485 -0.087982 0 0 0 0 0 0 6.74187 0 0 0 0 0 P82979 SARNP_HUMAN SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) SARNP HCC1 HSPC316 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723] ATETVELHK;ITSEIPQTER;ITSEIPQTERMQK 3 10.5 0.0089686 1.1732 0 0 11.3101 0 0 0 0 0 0 10.8016 11.0294 10.5413 P82987 ATL3_HUMAN ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) ADAMTSL3 KIAA1233 Homo sapiens (Human) extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231] CNTDSLDMCISGICQAVGCDR;EDNCGVCAGDGSTCR;IQIQNPTR;NCTSGACDVCWHTGPWKPCTAACGR;RHCVQKK;SEMKTKLGEQGPQILSVQR 6 5.6 0.97322 -2.5776 10.3904 0 0 0 0 5.86431 6.92707 10.3941 0 0 5.07116 0 P83110 HTRA3_HUMAN Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease) HTRA3 PRSP Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; proteolysis [GO:0006508] extracellular region [GO:0005576] endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] QIKDWKK;TITPSLVDELK 2 4 0.97192 -1.3598 0 0 0 0 0 0 11.1425 0 0 0 0 0 P83111 LACTB_HUMAN "Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)" LACTB MRPL56 UNQ843/PRO1781 Homo sapiens (Human) lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216] cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; peptidase activity [GO:0008233] FENSIESLR;FKTEQENEAK 2 3.5 0.98042 -1.6101 0 0 0 0 0 0 6.22865 0 0 0 0 9.36803 P83436 COG7_HUMAN Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) COG7 UNQ3082/PRO10013 Homo sapiens (Human) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; trans-Golgi network membrane [GO:0032588] EQMILVKEDIKK;IIATCGELLRHCGDFEQQLANR;SLAGFQESILTDK 3 6.1 0.93736 -0.5416 0 0 0 0 10.0337 10.1383 0 0 0 11.1133 0 6.67807 P83731 RL24_HUMAN Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) RPL24 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; exit from mitosis [GO:0010458]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AITGASLADIMAK;QKIVKPVKVSAPR;VFQFLNAK 3 21.7 0 3.5774 13.0116 13.0461 12.9265 0 10.0941 9.91088 11.8906 12.7384 12.8465 0 10.3265 12.2831 P83881 RL36A_HUMAN Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) RPL36A RPL44 GIG15 MIG6 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DSLYAQGK;KGQVIQF 2 14.2 0.93272 -0.51292 0 0 0 0 0 0 8.41198 0 0 0 0 0 P83916 CBX1_HUMAN Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) CBX1 CBX Homo sapiens (Human) DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892] "chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; female pronucleus [GO:0001939]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; spindle [GO:0005819]" chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064] IIGATDSSGELMFLMK;LTWHSYPSEDDDKKDDK;NSDEADLVPAK 3 23.8 0.72727 0.1267 0 0 0 0 0 0 0 0 0 0 5.15563 0 P84022 SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) SMAD3 MADH3 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-cell junction organization [GO:0045216]; cellular response to glucose stimulus [GO:0071333]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung blood pressure [GO:0061767]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; primary miRNA processing [GO:0031053]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of miRNA transcription [GO:1902893]; regulation of striated muscle tissue development [GO:0016202]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to angiotensin [GO:1990776]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; collagen binding [GO:0005518]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear mineralocorticoid receptor binding [GO:0031962]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" AITTQNVNTK;MSFVKGWGAEYR;SSILPFTPPIVK 3 8 0.039286 0.51175 0 0 0 0 0 0 4.63186 0 0 0 0 0 P84022 SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) SMAD3 MADH3 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-cell junction organization [GO:0045216]; cellular response to glucose stimulus [GO:0071333]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung blood pressure [GO:0061767]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; primary miRNA processing [GO:0031053]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of miRNA transcription [GO:1902893]; regulation of striated muscle tissue development [GO:0016202]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of transforming growth factor beta2 production [GO:0032909]; response to angiotensin [GO:1990776]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; wound healing [GO:0042060] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; collagen binding [GO:0005518]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear mineralocorticoid receptor binding [GO:0031962]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" ELCEFAFNMK;MSFVKGWGAEYR 2 6.9 0.81135 0.0037274 0 0 0 0 0 6.13744 0 0 0 0 0 0 P84085 ARF5_HUMAN ADP-ribosylation factor 5 ARF5 Homo sapiens (Human) "intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]" extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ILMVGLDAAGK;VQESADELQK 2 11.7 0 2.1303 0 0 0 0 0 0 0 0 0 9.74755 9.34154 0 P84090 ERH_HUMAN Enhancer of rudimentary homolog ERH Homo sapiens (Human) nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside metabolic process [GO:0006213] methylosome [GO:0034709]; midbody [GO:0030496]; nucleus [GO:0005634] methyl-CpG binding [GO:0008327]; RNA binding [GO:0003723] SHTILLVQPTK;TYADYESVNECMEGVCKMYEEHLKR 2 34.6 0 51.178 12.5319 12.6083 12.6188 9.50317 9.86996 10.4741 12.0477 12.2498 12.0098 11.776 11.8194 0 P84098 RL19_HUMAN Large ribosomal subunit protein eL19 (60S ribosomal protein L19) RPL19 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KPVTVHSRARCR;KVWLDPNETNEIANANSR;LASSVLR;LLADQAEAR;VWLDPNETNEIANANSR 5 23.5 0 9.5922 10.8919 11.3371 0 0 0 0 10.1657 0 0 10.1854 10.2913 10.482 P84103 SRSF3_HUMAN "Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)" SRSF3 SFRS3 SRP20 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; primary miRNA processing [GO:0031053]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] phospholipase binding [GO:0043274]; primary miRNA binding [GO:0070878]; protein-RNA sequence-specific adaptor activity [GO:0160134]; RNA binding [GO:0003723] AFGYYGPLR;GPPPSWGR;GPPPSWGRRPRDDYR;NPPGFAFVEFEDPR;NPPGFAFVEFEDPRDAADAVR;TLCGCRVR;VELSNGEK 7 37.2 0 4.361 0 10.2182 3.42586 0 0 8.2305 10.0355 10.3903 12.7167 8.7077 10.8539 10.9151 P84157 MXRA7_HUMAN Matrix-remodeling-associated protein 7 MXRA7 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] EAPAELLAALPALATALALLLAWLLVRR 1 13.7 0.71338 0.14947 0 0 0 0 0 0 0 0 0 0 0 5.74516 P84550 SKOR1_HUMAN SKI family transcriptional corepressor 1 (Functional Smad-suppressing element on chromosome 15) (Fussel-15) (LBX1 corepressor 1) (Ladybird homeobox corepressor 1) SKOR1 CORL1 FUSSEL15 LBXCOR1 Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]" EESSRSGRLEAK;EGRSGGK 2 2.2 0.68638 0.1636 0 0 0 0 9.87957 0 0 0 0 0 0 9.46567 P84996 ALEX_HUMAN Protein ALEX (Alternative gene product encoded by XL-exon) GNAS GNAS1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] AAAPGWR;HSGKLEPMEATAHLLR;LSDLLLTSR;STAAASSRQSRPR 4 7.2 0.97322 -2.88 12.2879 0 11.3159 10.2882 0 0 0 0 0 0 0 0 P85037 FOXK1_HUMAN Forkhead box protein K1 (Myocyte nuclear factor) (MNF) FOXK1 MNF Homo sapiens (Human) canonical glycolysis [GO:0061621]; cell differentiation [GO:0030154]; intracellular glucose homeostasis [GO:0001678]; muscle organ development [GO:0007517]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GVSCFRTPFGPLSSR 1 2 0.91936 -0.43679 0 0 0 0 0 0 0 0 0 5.35173 0 0 P85298 RHG08_HUMAN Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) ARHGAP8 Homo sapiens (Human) negative regulation of endocytic recycling [GO:2001136]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] SSHLSLPKYWDYR 1 2.8 0.95316 -0.67416 0 0 0 0 0 0 0 0 0 0 9.58118 0 P85299 PRR5_HUMAN Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) PRR5 PROTOR1 PP610 Homo sapiens (Human) cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell growth [GO:0030307]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; TORC2 signaling [GO:0038203] cytosol [GO:0005829]; TORC2 complex [GO:0031932] GVTEDYLRLETLVQK 1 3.9 0.91596 -0.43376 0 0 0 0 0 0 0 0 0 7.49985 0 0 P86397 HTD2_HUMAN "Hydroxyacyl-thioester dehydratase type 2, mitochondrial (HsHTD2) (EC 4.2.1.59) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase)" HTD2 Homo sapiens (Human) fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812] MFPLISSHHLWWGGLRR;TVCLNLPVLTLQHFQHMHIKVGDRAELR 2 26.8 0.95248 -0.75911 0 0 0 0 0 0 0 11.3256 0 0 8.76606 0 P86452 ZBED6_HUMAN Zinc finger BED domain-containing protein 6 ZBED6 Homo sapiens (Human) blastocyst hatching [GO:0001835]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357] centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]" AVPQLYDCVR;EAKQPAKK;FMQIVAPDYR;GITQALNLVDSLSLKLETDTLLSAMLK;QIYLPSTR 5 6.4 0.9649 -1.2283 0 0 8.62629 7.1814 6.80581 0 8.82142 8.73234 0 6.50217 0 0 P86791 CCZ1_HUMAN Vacuolar fusion protein CCZ1 homolog CCZ1 C7orf28A CGI-43 Homo sapiens (Human) vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658] guanyl-nucleotide exchange factor activity [GO:0005085] LEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDK;MTYLKIQSFINR;TFSPSKPAKSLHTQKNR 3 12.9 0.98012 -1.6526 8.90947 0 0 0 8.76202 0 8.83999 0 0 9.4671 0 0 P87889 GAK10_HUMAN Endogenous retrovirus group K member 10 Gag polyprotein (HERV-K10 Gag protein) (HERV-K107 Gag protein) (HERV-K_5q33.3 provirus ancestral Gag polyprotein) (Gag polyprotein) ERVK-10 Homo sapiens (Human) viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] ELKQAGRK;GTSPLPAGQVLVRLQPQKQVK;LQPQKQVK 3 4.4 0.88129 -0.15139 0 0 0 0 0 0 0 0 8.73748 0 0 6.29203 P98073 ENTK_HUMAN Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) proteolysis [GO:0006508] brush border [GO:0005903]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ADLFCDGEVNCPDGSDEDNK;FTEWIQSFLH;IVGGSNAK 3 3.7 0.96475 -1.2307 0 13.1318 0 0 0 0 0 0 0 0 6.16617 0 P98077 SHC2_HUMAN SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) SHC2 SCK SHCB Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; plasma membrane [GO:0005886] receptor tyrosine kinase binding [GO:0030971] CAAPCPLPALSRCR;GAGSRGSRGGR;KDLFDMRPFEDALK 3 6.7 0.98059 -1.6439 0 0 0 0 9.40527 0 8.45183 0 0 0 0 10.7274 P98082 DAB2_HUMAN Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) DAB2 DOC2 Homo sapiens (Human) "apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]" clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; SMAD binding [GO:0046332] TGKQEAQAGPWPFSSSQTQPAVR 1 3 0.94496 -0.63887 0 0 0 0 0 7.47289 11.4473 0 0 0 0 0 P98088 MUC5A_HUMAN "Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)" MUC5AC MUC5 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] ASNPAHNGRVCSTWGSFHYK;CLGPHGEPVK;DLAGHCYYALCSQDCQVVR;FANNTEGQCGTCTNDRKDECR;SIILEYHQDR;SRSVVGDVLEFGNSWK;VGCNTCTCDSRMWR 7 1.9 0.96702 -1.2913 0 9.7086 8.26195 0 9.62425 0 0 0 12.8469 0 0 0 P98095 FBLN2_HUMAN Fibulin-2 (FIBL-2) FBLN2 Homo sapiens (Human) positive regulation of cell-substrate adhesion [GO:0010811] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201] RCEDVNECEAQR;VTEDSEEEEEEEEER 2 2.3 0.4844 0.19001 0 0 0 5.54402 0 0 7.32544 0 0 0 0 0 P98155 VLDLR_HUMAN Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; lipid transport [GO:0006869]; memory [GO:0007613]; nervous system development [GO:0007399]; positive regulation of dendrite development [GO:1900006]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; regulation of synapse assembly [GO:0051963]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447] clathrin-coated pit [GO:0005905]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; very-low-density lipoprotein particle [GO:0034361] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor activity [GO:0030229] CDGDEDCVDGSDEK;CDGDPDCEDGSDESPEQCHMR;CDGDPDCEDGSDESPEQCHMRTCR;ESGATGTGRK;YTCSCPSGYNVEENGR 5 7.3 0.91722 -0.42792 0 8.51672 4.91198 0 5.60978 4.86547 3.86384 0 0 6.4548 0 0 P98160 PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of endothelial cell proliferation [GO:0001938]; receptor-mediated endocytosis [GO:0006898]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; low-density lipoprotein particle receptor binding [GO:0050750] AAGALLLALLLHGRLLAVTHGLR;ACTEAEFACHSYNECVALEYR;AVTLECVSAGEPR;GPSCQDCDTGYTR;LCNECADGSFHLSTR;LVSEDPINDGEWHR;VQVSPER;VTSYGGELR 8 2.6 0.88201 -0.16652 7.57266 5.18468 13.3708 0 8.3512 9.79812 0 0 9.65301 4.3099 0 10.8525 P98161 PKD1_HUMAN Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-independent cell-matrix adhesion [GO:0007161]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of epithelial cell polarity [GO:0090162]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; mitocytosis [GO:0160040]; neural tube development [GO:0021915]; nitrogen cycle metabolic process [GO:0071941]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein heterotetramerization [GO:0051290]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; skin development [GO:0043588]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055] basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; migrasome [GO:0140494]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133] calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; Wnt receptor activity [GO:0042813] ALDVAAEPK;DCVTYQTEYR;DRLRFLQLHNWLDNR;GLAASLLFLLLVKAAQQLR;LGAVILR;LQEALYPDPPGPR;SLHVLVFVLEVLR;VIYPAPRDGR 8 2.2 0.97602 -1.4744 0 7.56856 5.89356 0 7.09972 0 5.28255 0 0 9.60546 0 0 P98164 LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; aorta development [GO:0035904]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; cranial skeletal system development [GO:1904888]; diol metabolic process [GO:0034311]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; gene expression [GO:0010467]; kidney development [GO:0001822]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein transporter activity [GO:0140318]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124] CQSEGQCIPNSWVCDQDQDCDDGSDER;CSCDTGYMLESDGRTCK;EFICNGVDNCHDNNTSDEK;GFTCECPDDFR;GISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPK;HNDCGDYSDERGCLYQTCQQNQFTCQNGR;INTTYRR;RCIPQSWVCDGDVDCTDGYDENQNCTR;TCRPGQFR;TVEKGNK;WAVCNGVDDCR;WICDHYNDCGDNSDER;WQCDGQNDCGDNSDEENCAPRECTESEFR;YCEMAFSK 14 5.6 0.97517 -4.0984 4.04142 5.89625 9.69359 5.30045 0 6.78686 10.8592 8.64205 9.75794 6.11387 3.56864 0 P98168 ZXDA_HUMAN Zinc finger X-linked protein ZXDA ZXDA Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] KHLQDVDTWK 1 1.3 0.91513 -0.37766 0 0 0 0 0 0 14.8724 0 0 0 0 0 P98170 XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) XIAP API3 BIRC4 IAP3 Homo sapiens (Human) "copper ion homeostasis [GO:0055070]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neuron apoptotic process [GO:0051402]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; regulation of apoptotic process [GO:0042981]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; response to lipopolysaccharide [GO:0032496]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; endopeptidase regulator activity [GO:0061135]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] MTFNSFEGSK;YLLEQKGQEYINNIHLTHSLEECLVR 2 7.2 0.95259 -0.76436 0 0 0 0 0 0 0 0 0 0 11.4704 0 P98171 RHG04_HUMAN Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) ARHGAP4 KIAA0131 RGC1 RHOGAP4 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast migration [GO:0010764]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802] GQQQETETFYLTKLQEYLSGRSILAK;LLWRLPAPVLVVLR;RAEVELEYSR;WQLSEQLRCLELQGELR 4 7.1 0.96438 -1.1519 0 0 0 7.42013 7.07114 8.34261 10.1339 9.44193 8.24826 0 8.22699 11.2306 P98172 EFNB1_HUMAN Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] EFNB1 EFL3 EPLG2 LERK2 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; embryonic pattern specification [GO:0009880]; ephrin receptor signaling pathway [GO:0048013]; neural crest cell migration [GO:0001755]; positive regulation of T cell proliferation [GO:0042102]; regulation of autophagosome assembly [GO:2000785]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] ephrin receptor binding [GO:0046875] AEAGRPYEYYK 1 3.2 0.93228 -0.4945 0 0 0 0 0 0 0 9.81617 0 0 0 0 P98174 FGD1_HUMAN "FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)" FGD1 FGDY ZFYVE3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; animal organ morphogenesis [GO:0009887]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] AVELVNTWTER;GGKGWHK;LLKVYELLGGEEDIVSPTK;YPRIGDILQKLAPFLK 4 5.5 0.97117 -1.3467 10.0218 11.2499 9.81689 0 8.59335 8.13981 0 3.96366 0 0 0 0 P98175 RBM10_HUMAN RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 Homo sapiens (Human) "3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; vascular associated smooth muscle cell apoptotic process [GO:1905288]; vascular associated smooth muscle cell proliferation [GO:1990874]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] EVRLMRNK;HQQLSGLHK;LACLLCRR;SYPREYGSQEGK 4 4 0.98084 -2.0226 0 8.25682 2.63204 0 0 0 8.854 0 0 0 0 0 P98182 ZN200_HUMAN Zinc finger protein 200 ZNF200 ZNFMF Homo sapiens (Human) nucleus [GO:0005634] metal ion binding [GO:0046872] LSNCTRHEK 1 2.3 0.93598 -0.52708 0 0 0 0 0 0 0 0 0 0 7.13586 0 P98187 CP4F8_HUMAN Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] endoplasmic reticulum membrane [GO:0005789] "alkane 1-monooxygenase activity [GO:0018685]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" FDPENAQKR;ILAWTYAFYHNGR 2 4.2 0.85058 -0.075879 0 9.45713 0 0 0 0 0 0 12.6036 0 0 0 P98194 AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) ATP2C1 KIAA1347 PMR1L HUSSY-28 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629] cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] DSILTKNLILKILVSSIIIVCGTLFVFWR;ILVSSIIIVCGTLFVFWRELR;IPVLTSK;LVPPECHCVREGK;YCTTYQSK 5 6.6 0.96385 -1.0936 0 0 0 0 0 8.24351 0 0 0 10.1582 8.14476 0 P98194 AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) ATP2C1 KIAA1347 PMR1L HUSSY-28 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629] cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] DSILTKNLILKILVSSIIIVCGTLFVFWR;ILVSSIIIVCGTLFVFWRELR;IQKHVSSTSSSFLEVWLWER;LVPPECHCVREGK;YCTTYQSK 5 7.7 0.91568 -0.43096 0 0 0 0 0 0 0 0 8.83425 0 0 0 P98196 AT11A_HUMAN Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) ATP11A ATPIH ATPIS KIAA1021 Homo sapiens (Human) in utero embryonic development [GO:0001701]; phospholipid translocation [GO:0045332]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane lipid distribution [GO:0097035] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] TESERQR;VALQDREK 2 1.3 0.9782 -1.5029 7.81718 0 0 0 0 0 0 0 0 0 0 0 P98198 AT8B2_HUMAN Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) ATP8B2 ATPID KIAA1137 Homo sapiens (Human) Golgi organization [GO:0007030]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554] AVICCRVTPLQK;FLFWDPSLLEAVK;KKPSWGTEEERR;QKAQHRCMR;TLVLAYK 5 4.4 0.89747 -0.23899 9.89783 0 0 0 0 0 0 7.50526 0 0 10.4527 0 P99999 CYC_HUMAN Cytochrome c CYCS CYC Homo sapiens (Human) "apoptotic signaling pathway [GO:0097190]; cellular respiration [GO:0045333]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" apoptosome [GO:0043293]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] KIFIMKCSQCHTVEK 1 14.3 0.42648 0.19662 0 0 0 0 0 0 0 0 10.2709 0 0 0 Q00005 2ABB_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) PPP2R2B Homo sapiens (Human) apoptotic process [GO:0006915] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] DKRPEGYNLK;KILHTAWHPSENIIAVAATNNLYIFQDK;MFDRNTK;MIPGIGTLTQDTLWCFSQVK 4 14.5 0.96438 -1.1165 12.2451 6.04586 0 7.77538 0 0 0 0 0 0 0 7.0217 Q00013 EM55_HUMAN "55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)" MPP1 DXS552E EMP55 Homo sapiens (Human) regulation of neutrophil chemotaxis [GO:0090022]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] guanylate kinase activity [GO:0004385]; signaling receptor binding [GO:0005102] AQFDYDPK;ETKGMISLKVIPNQQSR 2 5.4 0.92938 -0.46536 0 0 7.95478 0 0 0 0 0 8.98973 0 0 0 Q00059 TFAM_HUMAN "Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)" TFAM TCF6 TCF6L2 Homo sapiens (Human) mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial transcription [GO:0006390]; positive regulation of DNA-templated transcription [GO:0045893]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; transcription initiation at mitochondrial promoter [GO:0006391] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; heat shock protein binding [GO:0031072]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223] AEWQVYK;AEWQVYKEEISR;ELPDSKK;ELYIQHAK;IYQDAYRAEWQVYK;WFSSVLASCPK 6 18.3 0.97452 -3.6233 0 12.5667 0 0 6.15344 0 0 0 0 0 0 0 Q00169 PIPNA_HUMAN Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) PITPNA PITPN Homo sapiens (Human) axonogenesis [GO:0007409]; lipid metabolic process [GO:0006629]; phospholipid transport [GO:0015914]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] WWGLQNK 1 2.6 0.90876 -0.30924 0 0 0 0 0 0 0 2.56854 0 0 0 10.8977 Q00266 METK1_HUMAN S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) MAT1A AMS1 MATA1 Homo sapiens (Human) methionine catabolic process [GO:0009087]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; S-adenosylmethionine biosynthetic process [GO:0006556] cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478] FVIGGPQGDAGVTGR;SAAYAAR 2 5.6 0.7755 0.04551 0 0 0 0 0 0 5.82163 0 0 0 0 0 Q00325 S25A3_HUMAN "Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP)" SLC25A3 PHC OK/SW-cl.48 Homo sapiens (Human) mitochondrial phosphate ion transmembrane transport [GO:1990547]; phosphate ion transmembrane transport [GO:0035435] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] phosphate transmembrane transporter activity [GO:0005315]; phosphate:proton symporter activity [GO:0015317]; protein-containing complex binding [GO:0044877] GSSASLVLK;GVAPLWMR;GVAPLWMRQIPYTMMK;IQTQPGYANTLR;LPRPPPPEMPESLK;MQVDPQK;TVEALYK 7 18 0 10.922 14.0451 13.2673 13.9664 11.375 10.0765 10.4932 13.0032 12.6146 12.7907 12.8809 12.8537 12.4587 Q00341 VIGLN_HUMAN Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) HDLBP HBP VGL Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869] cytoplasm [GO:0005737]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; lipid binding [GO:0008289]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] DCDPGSPR;EESNTKIDLPAENSNSETIIITGK;FHRSVMGPKGSR;FVIGKNGEK;IEGDPQGVQQAK;LVGEIMQETGTR;LVGEIMQETGTRINIPPPSVNR;QFHKNIIGKGGANIK;TLPWGPK;VIFPAAEDK 10 9.3 0.96653 -1.2757 10.3938 0 2.48481 0 0 7.78816 0 5.23001 0 9.16526 0 9.12021 Q00526 CDK3_HUMAN Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) CDK3 CDKN3 Homo sapiens (Human) cell division [GO:0051301]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; G0 to G1 transition [GO:0045023]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of Notch signaling pathway [GO:0045746]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; signal transduction [GO:0007165] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310] IGEGTYGVVYK;LADFGLAR;SYLFQLLQGVSFCHSHR 3 11.8 0.64213 0.17273 0 0 0 7.0735 0 0 0 0 0 0 0 0 Q00532 CDKL1_HUMAN Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE) CDKL1 Homo sapiens (Human) protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017] ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HSVIKLCDFGFAR;IGKIGEGSYGVVFK;YQRGVPEHLVK 3 10.6 0.98098 -1.5938 0 0 0 0 0 0 0 0 0 7.06577 0 0 Q00532 CDKL1_HUMAN Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE) CDKL1 Homo sapiens (Human) protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017] ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] GYSCALHGLR;HSVIKLCDFGFAR;IGKIGEGSYGVVFK;MELSTDTGWNQK;VTDQHRHR 5 5.7 0.97314 -2.8732 0 0 12.0142 0 0 0 11.2193 0 0 0 8.26552 7.50184 Q00534 CDK6_HUMAN Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) CDK6 CDKN6 Homo sapiens (Human) astrocyte development [GO:0014002]; cell dedifferentiation [GO:0043697]; cell division [GO:0051301]; dentate gyrus development [GO:0021542]; G1/S transition of mitotic cell cycle [GO:0000082]; generation of neurons [GO:0048699]; gliogenesis [GO:0042063]; hematopoietic stem cell differentiation [GO:0060218]; lateral ventricle development [GO:0021670]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of erythrocyte differentiation [GO:0045646]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; type B pancreatic cell development [GO:0003323] centrosome [GO:0005813]; cyclin D1-CDK6 complex [GO:0097131]; cyclin D2-CDK6 complex [GO:0097132]; cyclin D3-CDK6 complex [GO:0097133]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770]; protein serine kinase activity [GO:0106310] DLKNGGR;LADFGLAR 2 4.6 0.89819 -0.25701 0 0 0 0 0 0 8.74618 0 0 0 0 0 Q00536 CDK16_HUMAN Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 Homo sapiens (Human) exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; positive regulation of autophagy [GO:0010508]; protein phosphorylation [GO:0006468]; regulation of cell cycle phase transition [GO:1901987]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; spermatogenesis [GO:0007283] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] DLKPQNLLINER;LADFGLAR;LGEGTYATVYK;SLTLVFEYLDK 4 8.5 0.80686 0.012083 0 0 0 0 0 0 0 11.6883 0 0 0 0 Q00537 CDK17_HUMAN Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) CDK17 PCTAIRE2 PCTK2 Homo sapiens (Human) protein phosphorylation [GO:0006468]; regulation of cell cycle phase transition [GO:1901987] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] ISMEDLNK;LADFGLAR;LGEGTYATVYK;SLTLVFEYLDK;VLHRDLKPQNLLINEK 5 10.3 0.97039 -1.3444 0 0 0 0 0 0 13.2554 12.0283 0 0 0 10.5113 Q00587 BORG5_HUMAN Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) CDC42EP1 BORG5 CEP1 MSE55 Homo sapiens (Human) positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] cadherin binding involved in cell-cell adhesion [GO:0098641]; small GTPase binding [GO:0031267] LPRSEKPHDRDR;LSPVGWVSSSQGK 2 6.4 0.91136 -0.32404 0 0 11.292 0 6.30153 0 0 0 0 0 0 0 Q00610 CLH1_HUMAN Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 Homo sapiens (Human) "amyloid-beta clearance by transcytosis [GO:0150093]; autophagy [GO:0006914]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572]" clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588] clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381] AQILPIR;AYEFAER;DTELAEELLQWFLQEEKR;EAIDSYIK;ENPYYDSR;FICIREK;GQFSTDELVAEVEK;IYIDSNNNPER;LASTLVHLGEYQAAVDGAR;LDHTRAVNYFSKVK;LLLPWLEAR;LLYNNVSNFGR;NLQNLLILTAIK;NLQNLLILTAIKADRTR;NNLAGAEELFAR;SVNESLNNLFITEEDYQALR;VANVELYYR;VVGAMQLYSVDR;YIEIYVQK 19 12.6 0 10.634 13.3943 12 11.4796 0 0 10.1105 9.08039 12.8117 12.5919 12.0343 12.323 13.069 Q00613 HSF1_HUMAN Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) HSF1 HSTF1 Homo sapiens (Human) cellular response to angiotensin [GO:1904385]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to estradiol stimulus [GO:0071392]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamine [GO:1904845]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitroglycerin [GO:1904843]; cellular response to potassium ion [GO:0035865]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; cellular response to xenobiotic stimulus [GO:0071466]; defense response [GO:0006952]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of gene expression [GO:0010629]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to hypobaric hypoxia [GO:1990910]; response to nutrient [GO:0007584]; response to peptide [GO:1901652]; response to psychosocial stress [GO:1990911]; response to testosterone [GO:0033574] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; protein folding chaperone complex [GO:0101031]; ribonucleoprotein complex [GO:1990904] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; sequence-specific single stranded DNA binding [GO:0098847]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; translation elongation factor binding [GO:0061770]" QKHAQQQKVVNK 1 2.3 0.60664 0.17612 0 0 0 0 0 0 5.13787 0 0 0 0 0 Q00653 NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] NFKB2 LYT10 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; spleen development [GO:0048536] Bcl3/NF-kappaB2 complex [GO:0033257]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EPAPETADGPYLVIVEQPK;SLVDTYR 2 2.9 0.91045 -0.28814 0 0 0 0 0 0 0 9.4032 0 8.55332 0 0 Q00688 FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) FKBP3 FKBP25 Homo sapiens (Human) nucleus [GO:0005634] FK506 binding [GO:0005528]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; signaling receptor activity [GO:0038023] LNEDKPKETKSEETLDEGPPK;SEETLDEGPPK 2 9.4 0.012346 0.8767 0 0 0 0 0 0 0 0 0 9.84793 9.80896 0 Q00722 PLCB2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)" PLCB2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; G-protein beta/gamma-subunit complex [GO:0031680]; neuronal dense core vesicle [GO:0098992] calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phospholipid binding [GO:0005543] CVELDCWK;EHLTKFINQK;EQHVAEQISKMMELAREK;FVSFEFSAQK;GARRWEELLQR;GVVKLQRR;LEEKQAACLEQIR;LERIQGMTK;QMTENLERHQEK 9 8.4 0.97824 -6.3628 0 7.01033 8.02592 9.85649 8.0655 10.4608 11.9321 10.9569 7.28457 0 0 10.7421 Q00765 REEP5_HUMAN Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2) REEP5 C5orf18 DP1 TB2 Homo sapiens (Human) endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network [GO:0071782]; sarcoplasmic reticulum membrane [GO:0033017] AKETADAITKEAK;ATVNLLGEEK;ETADAITK;IIRPFFLKHESQMDSVVKDLK 4 23.3 0.89317 -0.22224 10.6149 10.7019 11.5022 8.4135 0 0 12.4163 12.1479 0 0 0 0 Q00839 HNRPU_HUMAN Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) HNRNPU C1orf199 HNRPU SAFA U21.1 Homo sapiens (Human) "adaptive thermogenesis [GO:1990845]; cardiac muscle cell development [GO:0055013]; cell division [GO:0051301]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; dosage compensation by inactivation of X chromosome [GO:0009048]; maintenance of protein location in nucleus [GO:0051457]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of kinase activity [GO:0033673]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; osteoblast differentiation [GO:0001649]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to spindle microtubule [GO:1902889]; random inactivation of X chromosome [GO:0060816]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of chromatin organization [GO:1902275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic spindle assembly [GO:1901673]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA localization to chromatin [GO:1990280]; RNA processing [GO:0006396]" catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; inactive sex chromosome [GO:0098577]; kinetochore [GO:0000776]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; mitotic spindle midzone [GO:1990023]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]; telomerase holoenzyme complex [GO:0005697] actin binding [GO:0003779]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; mRNA 3'-UTR binding [GO:0003730]; piRNA binding [GO:0034584]; poly(A) binding [GO:0008143]; poly(C) RNA binding [GO:0017130]; poly(G) binding [GO:0034046]; pre-mRNA binding [GO:0036002]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069]; telomerase RNA binding [GO:0070034]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription corepressor activity [GO:0003714] APQCLGK;ASYGVSK;AVVVCPK;DIDIHEVR;DLPEHAVLK;FIEIAAR;GGGHRGR;GYFEYIEENK;LNTLLQR;NFILDQTNVSAAAQR;NGQDLGVAFK;SSGPTSLFAVTVAPPGAR;SSSPVNVK;SSSPVNVKK;TCNCETEDYGEK;TQKKAEVEGK;VTEKIPVR;YNILGTNTIMDK 18 19.8 0 45.114 14.391 14.748 14.3117 11.6176 11.713 11.449 14.5441 13.8775 14.1097 13.5214 12.9237 13.2683 Q00872 MYPC1_HUMAN "Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)" MYBPC1 MYBPCS Homo sapiens (Human) cell adhesion [GO:0007155]; sarcomere organization [GO:0045214] cytosol [GO:0005829]; M band [GO:0031430]; myofibril [GO:0030016]; myosin filament [GO:0032982] actin binding [GO:0003779]; myosin binding [GO:0017022]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432] NAKPSEYEK;QQEEEPQVDVWELLK;QSSRWMRLNFDLCK 3 3.3 0.93678 -0.55533 10.2169 0 0 0 0 0 0 0 0 10.5633 9.0427 0 Q00887 PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7) PSG9 PSG11 Homo sapiens (Human) Fc receptor mediated inhibitory signaling pathway [GO:0002774]; female pregnancy [GO:0007565]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of immune system process [GO:0002682]; regulation of regulatory T cell differentiation [GO:0045589]; signal transduction [GO:0007165]; tolerance induction dependent upon immune response [GO:0002461]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transforming growth factor beta ligand-receptor complex [GO:0070021] protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877] TNRTLYLFGVTK 1 2.8 0.924 -0.44971 0 0 0 0 0 0 0 0 3.68896 0 0 0 Q00888 PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 (PS-beta-G-4) (PSBG-4) (Pregnancy-specific glycoprotein 4) (Pregnancy-specific beta-1-glycoprotein 9) (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) PSG4 CGM4 PSG9 Homo sapiens (Human) female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] ENKDVLTFTCEPK 1 3.1 0.96739 -1.3143 13.2166 0 0 9.5775 0 8.75168 0 0 0 0 0 0 Q008S8 ECT2L_HUMAN Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) guanyl-nucleotide exchange factor activity [GO:0005085] AALSSNR;AQSIGIFSDGDSR;EMIPAFR;QRQEFLFAIFLRCTK 4 4.6 0.93229 -0.4924 0 0 0 0 0 7.99283 6.93511 0 0 0 9.11608 0 Q00973 B4GN1_HUMAN "Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) ((N-acetylneuraminyl)-galactosylglucosylceramide) (GM2/GD2 synthase) (GalNAc-T)" B4GALNT1 GALGT SIAT2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid metabolic process [GO:0006687]; limb development [GO:0060173]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; motor behavior [GO:0061744]; nerve development [GO:0021675]; spermatogenesis [GO:0007283]; vacuole organization [GO:0007033] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity [GO:0003947]; acetylgalactosaminyltransferase activity [GO:0008376] GWFAGRNLAVSQVTTK;VGSCSDVVVDHASK;VSGPYVEHYLMPFGK 3 8.4 0.94375 -0.62776 0 0 0 0 0 0 9.91021 0 9.12585 0 0 11.1165 Q00975 CAC1B_HUMAN "Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)" CACNA1B CACH5 CACNL1A5 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; response to amyloid-beta [GO:1904645] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] ECAGAKGER;EEVEAQPRQWK;FHKACFPNSTDAEPVGDFPCGKEAPAR;LLRIFKVTK;QQQIERELNGYLEWIFK;VAYKRLVR;VLRPLKLVSGIPSLQVVLK;VLRPLKTIKR 8 4.7 0.97568 -3.3338 6.77821 0 0 8.26828 0 0 0 0 0 6.12582 10.0895 8.9281 Q00978 IRF9_HUMAN Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) IRF9 ISGF3G Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IPWKHAGKQDFR;VYQLLPPGIVSGQPGTQKVPSK 2 8.7 0.96162 -1.0714 0 0 9.52233 0 0 0 0 0 0 0 13.366 0 Q00987 MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) MDM2 Homo sapiens (Human) "amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to alkaloid [GO:0071312]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gamma radiation [GO:0071480]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to UV-C [GO:0071494]; cellular response to vitamin B1 [GO:0071301]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endocardial cushion morphogenesis [GO:0003203]; establishment of protein localization [GO:0045184]; fibroblast activation [GO:0072537]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of heart rate [GO:0002027]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein catabolic process [GO:0042176]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to ether [GO:0045472]; response to formaldehyde [GO:1904404]; response to iron ion [GO:0010039]; response to magnesium ion [GO:0032026]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; traversing start control point of mitotic cell cycle [GO:0007089]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular septum development [GO:0003281]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] 5S rRNA binding [GO:0008097]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ligase activity [GO:0016874]; NEDD8 ligase activity [GO:0061663]; p53 binding [GO:0002039]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; receptor serine/threonine kinase binding [GO:0033612]; ribonucleoprotein complex binding [GO:0043021]; SUMO transferase activity [GO:0019789]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IYTMIYR;MTKRLYDEK 2 3.7 0.93784 -0.57422 0 0 0 0 0 0 0 0 0 9.75051 12.8501 0 Q01064 PDE1B_HUMAN "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)" PDE1B PDES1B Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; dopamine catabolic process [GO:0042420]; locomotory behavior [GO:0007626]; monocyte differentiation [GO:0030224]; response to amphetamine [GO:0001975]; serotonin metabolic process [GO:0042428]; visual learning [GO:0008542] cytosol [GO:0005829]; neuronal cell body [GO:0043025] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" GRRAEEKPK;IQENKQK;SVLENHHISSVFR 3 5.4 0.97595 -1.4495 0 0 0 0 0 0 0 0 0 0 0 10.9814 Q01081 U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) U2AF1 U2AF35 U2AFBP FP793 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; RS domain binding [GO:0050733] AEYLASIFGTEK;NPQNSSQSADGLR 2 10.4 0 5.6851 0 0 0 0 0 0 0 8.46017 0 0 9.10213 0 Q01082 SPTB2_HUMAN "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; central nervous system development [GO:0007417]; central nervous system formation [GO:0021556]; Golgi to plasma membrane protein transport [GO:0043001]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of SMAD protein signal transduction [GO:0060390] axolemma [GO:0030673]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; M band [GO:0031430]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; GTPase binding [GO:0051020]; phospholipid binding [GO:0005543]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200] DALLLWCQMK;DLTSVMRLLSKHR;DLVAIEAK;DTGNIGQER;DVSSVELLMNNHQGIK;EIKAQQDK;ELALRNELIR;ENEVLEAWK;EQWLNNMQIPEK;EVAELTR;ISMRQSKVDK;KRRPPSPEPSTK;LLEVLSGER;LQAAYAGDKADDIQKR;LTTLELLEVRR;LVDTGDK;LVSDGNINSDR;MLIKLLEVLSGERLPKPTK;QLQEDAAR;SQNIVTDSSSLSAEAIR;TALPAQSAATLPAR;VAVVNQIAR;VLDNAIETEK 23 10.4 0.97488 -1.4301 11.3248 12.6097 0 9.97828 0 10.4552 0 11.2706 13.1503 10.1054 8.60081 6.19385 Q01094 E2F1_HUMAN Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) E2F1 RBBP3 Homo sapiens (Human) anoikis [GO:0043276]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA-templated transcription [GO:0006351]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell apoptotic process [GO:1990086]; mRNA stabilization [GO:0048255]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" SIADPAEQMVMVIK 1 3.2 0.86508 -0.087135 0 0 0 10.2564 0 0 0 0 0 0 0 0 Q01101 INSM1_HUMAN Insulinoma-associated protein 1 (Zinc finger protein IA-1) INSM1 IA1 Homo sapiens (Human) adrenal chromaffin cell differentiation [GO:0061104]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; noradrenergic neuron development [GO:0003358]; norepinephrine biosynthetic process [GO:0042421]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]; sympathetic ganglion development [GO:0061549]; transdifferentiation [GO:0060290]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell differentiation [GO:0003309] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APEPEAAAR;IKEGPVEAPR;KSTPVSYR 3 5.3 0.97471 -2.3989 0 0 0 0 0 0 0 0 9.69518 0 0 0 Q01105 SET_HUMAN Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) DNA replication [GO:0006260]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] EFHLNESGDPSSK;ELNSNHDGADETSEK;LNEQASEEILK;MSAPAAK;VEVTEFEDIK 5 20.2 0 20.043 13.0962 13.2304 12.6993 10.4023 8.78015 0 11.4911 11.7988 12.6414 12.6326 11.5592 0 Q01118 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) SCN7A SCN6A Homo sapiens (Human) cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular homeostasis [GO:0019725]; osmosensory signaling pathway [GO:0007231]; response to bacterium [GO:0009617]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725] glial cell projection [GO:0097386]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] osmolarity-sensing monoatomic cation channel activity [GO:1990760]; sodium channel activity [GO:0005272]; transmembrane transporter binding [GO:0044325]; voltage-gated sodium channel activity [GO:0005248] IVENNWFK;SKKICPLYWYK;TREELKPLISMKFLRPLR 3 2.2 0.93387 -0.51029 0 0 0 6.824 9.16118 7.39215 6.63323 0 0 0 0 0 Q01130 SRSF2_HUMAN "Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)" SRSF2 SFRS2 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to vitamin E [GO:0033197]; RNA splicing [GO:0008380]" cytosol [GO:0005829]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; spliceosomal complex [GO:0005681] pre-mRNA binding [GO:0036002]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] TSPDTLR;VDNLTYR;VGDVYIPR 3 10 0.034735 0.55917 0 11.5034 0 0 0 0 0 0 0 0 0 0 Q01167 FOXK2_HUMAN Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) FOXK2 ILF ILF1 Homo sapiens (Human) canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; magnesium ion binding [GO:0000287]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" EKQEASESPVK;GAGSSGYK;ITFTALSSEKREK 3 4.5 0.9347 -0.53041 0 0 0 0 0 0 0 10.4783 0 7.60073 0 0 Q01196 RUNX1_HUMAN Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) "cardiac muscle tissue regeneration [GO:0061026]; chondrocyte differentiation [GO:0002062]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; myeloid cell differentiation [GO:0030099]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell differentiation [GO:0045595]; regulation of connective tissue replacement [GO:1905203]; regulation of plasminogen activation [GO:0010755]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]" ITVDGPR;QIQPSPPWSYDQS 2 7.8 0.93702 -0.5435 0 0 0 0 0 0 9.87793 0 0 3.64939 0 0 Q01201 RELB_HUMAN Transcription factor RelB (I-Rel) RELB Homo sapiens (Human) antigen processing and presentation [GO:0019882]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to osmotic stress [GO:0071470]; circadian regulation of gene expression [GO:0032922]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lymphocyte differentiation [GO:0030098]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]; T-helper 1 cell differentiation [GO:0045063] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GMRFRYECEGR 1 1.9 0.97944 -1.5434 0 0 0 0 0 0 0 0 0 0 9.34219 0 Q01344 IL5RA_HUMAN Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125) IL5RA IL5R Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of interleukin-5 production [GO:0032674]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-5 receptor activity [GO:0004914] GFSASVR;ITESKCVTILHK;LMTNAFISIIDDLSKYDVQVR 3 9.5 0.95538 -0.80988 0 10.4437 0 0 0 8.96656 0 0 0 12.1337 0 0 Q01362 FCERB_HUMAN High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2) MS4A2 APY FCER1B IGER Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886] IgE binding [GO:0019863] AGYPFWGAIFFSISGMLSIISERR;LLKSASSPPLHTWLTVLK 2 17.2 0.3965 0.21208 0 0 9.07473 8.35116 0 0 0 0 0 0 0 0 Q01432 AMPD3_HUMAN AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) AMPD3 Homo sapiens (Human) AMP catabolic process [GO:0006196]; AMP metabolic process [GO:0046033]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] LAYHRFPR;SFKMIRSQSLSLQMPPQQDWK 2 3.8 0.96637 -1.1288 0 0 0 0 7.64667 0 0 0 0 0 0 0 Q01433 AMPD2_HUMAN AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cholesterol homeostasis [GO:0042632]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; GTP metabolic process [GO:0046039]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]; podocyte development [GO:0072015] cytosol [GO:0005829] AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] DVLEREFQR;LARWAVMHRVHSPNVR 2 3 0.97413 -2.458 0 0 0 0 0 9.78557 0 0 0 0 10.2739 0 Q01459 DIAC_HUMAN Di-N-acetylchitobiase (EC 3.2.1.-) CTBS CTB Homo sapiens (Human) chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313] extracellular space [GO:0005615]; lysosome [GO:0005764] chitin binding [GO:0008061]; chitinase activity [GO:0004568] LVSSPPSGVPGLALLALLALLALR 1 6.2 0.70923 0.15634 0 0 0 7.68706 0 0 0 0 0 0 0 0 Q01484 ANK2_HUMAN Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 ANKB Homo sapiens (Human) atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018] ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325] DESSVQSSRSER;DIPPDETQSTQK;EDLEKVNEILR;EETLSEDVK;ILQLGPPGTKFLGPVIVEIPHFAALRGK;LPVKVPLQR;QGANVNAK;QKQKEEGLQASAEK;TETTTEIRSEK;TETTTEIRSEKEHPTTK;TLEQQENFAEVAR;TSTDFSEVIK;VKEDLEK 13 3.7 0.9735 -2.6488 0 13.2362 0 8.46736 7.87989 8.52462 10.2127 9.13109 9.10003 0 11.1901 8.80851 Q01518 CAP1_HUMAN Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 CAP Homo sapiens (Human) actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; modification of postsynaptic actin cytoskeleton [GO:0098885]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179] ADMQNLVER;EIGGDVQK;EPAVLELEGKK;WRVENQENVSNLVIEDTELK 4 10.1 0.013725 0.7798 0 0 0 0 0 0 0 0 0 10.2577 13.9094 10.1616 Q01524 DEF6_HUMAN "Defensin-6 (Defensin, alpha 6)" DEFA6 DEF6 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; disruption of plasma membrane integrity in another organism [GO:0051673]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; transport vesicle [GO:0030133] protein homodimerization activity [GO:0042803] AEPLQAEDDPLQAK 1 14 0.7835 0.024225 0 0 0 0 0 0 0 8.67888 0 0 0 0 Q01534 TSPY1_HUMAN Testis-specific Y-encoded protein 1 (Cancer/testis antigen 78) (CT78) TSPY1 TSPY Homo sapiens (Human) cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] IAEILCKDLWRNPLQYYK;SNPYFQNKVITKEYLVNITEYR 2 13 0.097561 0.37068 0 0 0 0 8.16656 0 0 0 0 0 7.38793 0 Q01538 MYT1_HUMAN Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]" AKKSGVK;CPVPGCVGLGHISGK;SLSGCPIAAAEK;SLSGCPRATFAGK 4 4.2 0.80866 0.0065718 11.1024 11.4191 0 0 0 0 0 0 7.25219 0 0 0 Q01543 FLI1_HUMAN Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) FLI1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; hemostasis [GO:0007599]; megakaryocyte development [GO:0035855]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" NIMTKVHGK;RVIVPADPTLWTQEHVR 2 5.8 0.58039 0.17995 0 0 0 0 0 0 10.4784 0 0 0 0 0 Q01546 K22O_HUMAN "Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)" KRT76 KRT2B KRT2P Homo sapiens (Human) cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; pigmentation [GO:0043473]; sebaceous gland development [GO:0048733] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] AGGFGGGR;AQYEEIAQR;FASFIDK;FASFIDKVR;FLEQQNK;FLEQQNKVLETK;LGELQTTAGR;LGELQTTAGRHGDDLR;MIQRLRAEIENVK;SISISVAAGSSRAGGFGGGR 10 12.4 0.97601 -1.482 0 8.33119 0 0 14.4513 0 0 8.49013 0 8.81702 11.4535 9.92056 Q01581 HMCS1_HUMAN "Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)" HMGCS1 HMGCS Homo sapiens (Human) "acetyl-CoA metabolic process [GO:0006084]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; lipid metabolic process [GO:0006629]" cytoplasm [GO:0005737]; cytosol [GO:0005829] hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; protein homodimerization activity [GO:0042803] ASSELFSQK;DVEKAFMK;VDEKHRR;VTQDATPGSALDK 4 7.1 0.97511 -3.4487 0 0 0 0 0 9.30008 0 10.6131 0 0 0 0 Q01650 LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) SLC7A5 CD98LC LAT1 MPE16 Homo sapiens (Human) alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; cellular response to glucose starvation [GO:0042149]; cellular response to L-arginine [GO:1903577]; cellular response to lipopolysaccharide [GO:0071222]; isoleucine transport [GO:0015818]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; L-tryptophan transmembrane transport [GO:1904556]; liver regeneration [GO:0097421]; methionine transport [GO:0015821]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of L-leucine import across plasma membrane [GO:1905534]; positive regulation of type II interferon production [GO:0032729]; proline transport [GO:0015824]; response to hyperoxia [GO:0055093]; response to muscle activity [GO:0014850]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; xenobiotic transport [GO:0042908] amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; L-tryptophan transmembrane transporter activity [GO:0015196]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; thyroid hormone transmembrane transporter activity [GO:0015349] ALAAPAAEEKEEAR;LFFVGSR;LMQVVPQET;MAGAGPK;SADGSAPAGEGEGVTLQR 5 10.8 0 83.584 0 0 3.30189 0 0 0 13.9895 12.8211 12.8186 12.8188 7.75636 0 Q01664 TFAP4_HUMAN Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) TFAP4 BHLHC41 Homo sapiens (Human) "cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein-containing complex assembly [GO:0065003]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" EYFMVPTQK;LLHQEKLEREQQQLR;SCPEAPTSDTASDSEASDSDAMDQSR 3 14.8 0.84732 -0.061911 0 0 5.62281 0 0 0 0 10.0627 0 7.47735 0 0 Q01668 CAC1D_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3)" CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; sensory perception of sound [GO:0007605] L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; ankyrin binding [GO:0030506]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059] AFRVLRPLRLVSGVPSLQVVLNSIIK;EEEDDVFKR;ILRVLRVLRPLR;ISELNMKEK;RAISCDLQDDEPEETKR;TLHDIGPEIR;VLRVLRPLRAINR;VTRHWTSLSNLVASLLNSMK 8 5 0.9549 -0.7884 0 0 0 0 0 10.9235 10.8867 9.80379 0 9.50357 8.08529 11.3436 Q01740 FMO1_HUMAN Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase) FMO1 Homo sapiens (Human) energy homeostasis [GO:0097009]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; response to lipopolysaccharide [GO:0032496]; sulfur amino acid catabolic process [GO:0000098]; taurine biosynthetic process [GO:0042412]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" IITGKVFIRPSIK;IITGKVFIRPSIKEVK;TQLKEFVLNDELPGR 3 5.8 0.95407 -0.8872 0 0 0 0 0 0 0 11.2367 4.72241 0 0 0 Q01780 EXOSX_HUMAN Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) EXOSC10 PMSCL PMSCL2 RRP6 Homo sapiens (Human) "CUT catabolic process [GO:0071034]; DNA repair [GO:0006281]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent antisense transcript catabolic process [GO:0071040]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; ribosomal small subunit biogenesis [GO:0042274]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; single-stranded RNA binding [GO:0003727]; telomerase RNA binding [GO:0070034] IAEELPK;LKISKKPK;LLHAKNIIRPQLK;QSVGNKSMSFPTGK;TVVSSWNR 5 5.6 0.98081 -1.7777 0 0 11.2417 0 0 0 0 0 10.4107 0 0 12.016 Q01804 OTUD4_HUMAN OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) OTUD4 HIN-1 KIAA1046 Homo sapiens (Human) DNA alkylation repair [GO:0006307]; innate immune response [GO:0045087]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of protein K48-linked deubiquitination [GO:1903093] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723] AVAEQVLHSQSRHVEVR;ENREKFEAFIEGSFEEYLK 2 3.2 0.87149 -0.095381 9.32784 0 0 0 0 0 10.9365 0 0 0 0 0 Q01813 PFKAP_HUMAN "ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)" PFKP PFKF Homo sapiens (Human) "canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]" 6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877] AIGVLTSGGDAQGMNAAVR;AMEWITAK;ELVVTQLGYDTR;ISARAMEWITAK;LAIKLPDDQIPK;LSENRAR;MDADDSR;MGIYVGAK;NVIFQPVAELK 9 11.2 0.93434 -0.50415 12.6206 14.2211 0 11.3255 10.5897 0 12.2825 10.8438 12.8263 12.1344 11.3692 12.3435 Q01814 AT2B2_HUMAN Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) ATP2B2 PMCA2 Homo sapiens (Human) calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dendritic spine membrane [GO:0032591]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body membrane [GO:0032809]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate receptor binding [GO:0035254]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905059]; PDZ domain binding [GO:0030165] MVTGDNINTAR;VIEPMACDGLR 2 1.8 0.89825 -0.23167 0 0 0 0 0 0 0 0 0 0 8.07959 0 Q01826 SATB1_HUMAN DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) SATB1 Homo sapiens (Human) chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" DRIYQDER;EEDPKTASQSLLVNLR;IARLEQNGSPLGRGR;SQGWLCELLRWK;TLWENLSMIR;VSQALFAK 6 9 0.9745 -3.7679 0 11.2015 0 0 0 0 0 0 13.2713 9.12182 3.86661 0 Q01831 XPC_HUMAN DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) XPC XPCC Homo sapiens (Human) DNA repair [GO:0006281]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; UV-damage excision repair [GO:0070914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 2 complex [GO:0000111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; XPC complex [GO:0071942] bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; heteroduplex DNA loop binding [GO:0000404]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] ALGNWKLLAKGLLIR;DFPSDLKKAHHLK;LEFETYLRR 3 3.9 0.86412 -0.084341 0 0 0 3.66426 0 0 8.74079 0 0 0 0 7.4623 Q01844 EWS_HUMAN RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) EWSR1 EWS Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] GDATVSYEDPPTAK 1 2.1 0.039356 0.51557 0 8.32513 8.48752 0 0 0 0 7.58353 0 9.06199 0 0 Q01850 CDR2_HUMAN Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) CDR2 PCD17 Homo sapiens (Human) cytoplasm [GO:0005737] GHEETCIRRAK;LVADSKASQQK 2 4.8 0.97565 -1.4591 0 0 0 0 9.36855 0 0 0 0 8.31768 0 0 Q01860 PO5F1_HUMAN "POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)" POU5F1 OCT3 OCT4 OTF3 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; BMP signaling pathway [GO:0030509]; cardiac cell fate determination [GO:0060913]; cell fate commitment involved in formation of primary germ layer [GO:0060795]; endodermal cell fate specification [GO:0001714]; endodermal-mesodermal cell signaling [GO:0003133]; heart induction [GO:0003129]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of asymmetric cell division [GO:0009786]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]" LEQNPEESQDIK;VFSQTTICRFEALQLSFK 2 8.3 0.96497 -1.156 0 0 0 0 0 0 14.8122 9.68968 0 0 13.6743 0 Q01860 PO5F1_HUMAN "POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)" POU5F1 OCT3 OCT4 OTF3 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; BMP signaling pathway [GO:0030509]; cardiac cell fate determination [GO:0060913]; cell fate commitment involved in formation of primary germ layer [GO:0060795]; endodermal cell fate specification [GO:0001714]; endodermal-mesodermal cell signaling [GO:0003133]; heart induction [GO:0003129]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of asymmetric cell division [GO:0009786]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; somatic stem cell population maintenance [GO:0035019] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]" FLNPEWK;VFSQTTICRFEALQLSFK 2 9.4 0.90908 -0.31353 0 0 0 0 0 8.61014 0 0 0 0 0 0 Q01892 SPIB_HUMAN Transcription factor Spi-B SPIB Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SCACTSSCWGY 1 6.2 0.80728 0.007099 0 0 0 0 0 4.49403 0 0 0 0 0 0 Q01954 BNC1_HUMAN Zinc finger protein basonuclin-1 BNC1 BNC Homo sapiens (Human) cell differentiation [GO:0030154]; epidermis development [GO:0008544]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of transcription by RNA polymerase I [GO:0006356]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription activator activity [GO:0001216]; metal ion binding [GO:0046872]; rDNA binding [GO:0000182] IHYNAVHLKIKHK;LHMPMNRNNR 2 2.3 0.90521 -0.27113 0 7.34731 0 0 0 0 0 0 0 0 5.94331 0 Q01955 CO4A3_HUMAN Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin] COL4A3 Homo sapiens (Human) cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endothelial cell apoptotic process [GO:0072577]; extracellular matrix organization [GO:0030198]; glomerular basement membrane development [GO:0032836]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; response to glucose [GO:0009749]; sensory perception of sound [GO:0007605] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metalloendopeptidase inhibitor activity [GO:0008191]; structural molecule activity [GO:0005198] DKGQCFCDGAK;GCVCKDKGQCFCDGAK;GEKGNPGFLGSIGPPGPIGPK;GSKGERGRPGK;SARTAPRPQVLLLPLLLVLLAAAPAASK 5 4.6 0.97859 -1.9083 0 0 0 0 0 0 11.6901 5.77655 11.9792 0 10.0418 0 Q01959 SC6A3_HUMAN Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) SLC6A3 DAT1 Homo sapiens (Human) adenohypophysis development [GO:0021984]; amino acid transport [GO:0006865]; cognition [GO:0050890]; dopamine biosynthetic process [GO:0042416]; dopamine catabolic process [GO:0042420]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; dopamine uptake involved in synaptic transmission [GO:0051583]; hyaloid vascular plexus regression [GO:1990384]; lactation [GO:0007595]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; positive regulation of multicellular organism growth [GO:0040018]; prepulse inhibition [GO:0060134]; regulation of dopamine metabolic process [GO:0042053]; response to cAMP [GO:0051591]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; flotillin complex [GO:0016600]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amine binding [GO:0043176]; dopamine binding [GO:0035240]; dopamine:sodium symporter activity [GO:0005330]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; protease binding [GO:0002020]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102] ELVDRGEVRQFTLR 1 2.3 0.96162 -1.0714 0 0 0 0 0 0 0 0 0 8.11608 0 0 Q01968 OCRL_HUMAN "Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)" OCRL OCRL1 Homo sapiens (Human) cilium assembly [GO:0060271]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; lipid metabolic process [GO:0006629]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; Golgi-associated vesicle [GO:0005798]; lysosome [GO:0005764]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] "GTPase activator activity [GO:0005096]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; small GTPase binding [GO:0031267]" EVPVTKLIDLEEDSFLEKEK;FIPTYKYDSK;VQGDWIRER 3 4.3 0.95797 -1.0184 12.7608 0 13.9807 9.99138 0 9.8965 0 12.6097 12.6186 12.7948 0 12.138 Q01970 PLCB3_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)" PLCB3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; regulation of systemic arterial blood pressure [GO:0003073]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] EDEEEDEEEEEQTDPK;HDRLVAGQQQVLQQLAEEEPK;HNSISEAKMRDK;IAAFEEGGK;LNEVLYPPLRPSQAR;RNKCFEMSSFVETK;VISGQFLSDR 7 7.9 0.96346 -1.1077 0 10.7821 10.6179 0 0 0 10.6176 0 9.43396 0 7.06587 7.08279 Q01973 ROR1_HUMAN "Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)" ROR1 NTRKR1 Homo sapiens (Human) astrocyte development [GO:0014002]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; inner ear development [GO:0048839]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605] axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725] ATP binding [GO:0005524]; coreceptor activity [GO:0015026]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] EAPWCFTLDENFK;ELPLSAVRFMEELGECAFGK;GTRPPLLALLAALLLAAR;VSGNPPPTIRWFK 4 6.8 0.93295 -0.50065 0 0 0 0 5.58817 0 11.6471 0 0 7.72867 0 0 Q01974 ROR2_HUMAN "Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)" ROR2 NTRKR2 Homo sapiens (Human) "astrocyte development [GO:0014002]; bone mineralization [GO:0030282]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; macrophage migration [GO:1905517]; male genitalia development [GO:0030539]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic signaling by nitric oxide [GO:0150045]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; Wnt-protein binding [GO:0017147] FKDIHSRLR;NVLVYDKLNVKISDLGLFR 2 3 0.97326 -2.5335 7.53224 0 0 0 0 0 0 0 0 0 0 0 Q01995 TAGL_HUMAN Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) TAGLN SM22 WS3-10 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; muscle organ development [GO:0007517] cytoplasm [GO:0005737] actin binding [GO:0003779] LVNSLYPDGSKPVK;QMEQVAQFLK;TLMALGSLAVTK;YDEELEER 4 21.9 0.77878 0.039558 11.5076 0 11.5605 8.4477 8.6431 0 0 9.66404 0 9.75368 0 0 Q02040 AK17A_HUMAN "A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)" AKAP17A CXYorf3 DXYS155E SFRS17A XE7 Homo sapiens (Human) B cell activation [GO:0042113]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; signal transduction [GO:0007165] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] protein kinase A binding [GO:0051018]; RNA binding [GO:0003723] LQAEEQK;LRLQQQEERR;SLVKSFLACLDGKTIK 3 4.7 0.97756 -1.9532 0 0 0 0 4.90881 0 0 0 0 0 5.31832 0 Q02045 MYL5_HUMAN Myosin light chain 5 (Myosin regulatory light chain 5) (Superfast myosin regulatory light chain 2) (MYLC2) (MyLC-2) MYL5 Homo sapiens (Human) regulation of muscle contraction [GO:0006937] cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859] calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307] AQRASSNVFSNFEQTQIQEFK;ASSNVFSNFEQTQIQEFK 2 12.1 0.93643 -0.54818 0 0 0 0 0 0 0 10.9511 0 0 0 0 Q02078 MEF2A_HUMAN Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) MEF2A MEF2 Homo sapiens (Human) apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; DNA-templated transcription [GO:0006351]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mitochondrial genome maintenance [GO:0000002]; mitochondrion distribution [GO:0048311]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of D-glucose import [GO:0046326]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ventricular cardiac myofibril assembly [GO:0055005] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]" INEEFDNMMR 1 2 0.8048 0.013003 0 0 0 0 0 0 0 3.51765 0 0 0 0 Q02080 MEF2B_HUMAN Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) MEF2B XMEF2 Homo sapiens (Human) cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944] cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KIQISRILDQR;TPPPLYLPTEGRR 2 6.5 0.87875 -0.14374 12.4343 0 0 0 0 0 0 0 0 0 10.8862 0 Q02086 SP2_HUMAN Transcription factor Sp2 SP2 KIAA0048 Homo sapiens (Human) immune response [GO:0006955]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FMRSDHLTKHYK 1 2 0.87104 -0.095841 0 0 0 0 0 0 0 0 0 0 4.0597 0 Q02108 GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) GUCY1A1 GUC1A3 GUCSA3 GUCY1A3 Homo sapiens (Human) "blood circulation [GO:0008015]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; regulation of blood pressure [GO:0008217]; relaxation of vascular associated smooth muscle [GO:0060087]; response to oxygen levels [GO:0070482]; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0098925]" "cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; signaling receptor activity [GO:0038023] EDDFLHVYYFFPKR;QSSHCQEAGKRGR 2 3.9 0.75021 0.078533 0 0 8.68106 0 0 0 0 0 0 0 7.2341 0 Q02127 PYRD_HUMAN "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" DHODH Homo sapiens (Human) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] dihydroorotase activity [GO:0004151]; dihydroorotate dehydrogenase (quinone) activity [GO:0106430]; dihydroorotate dehydrogenase activity [GO:0004152] VLGPLADYLVVNVSSPNTAGLR 1 5.6 0.89188 -0.21218 0 0 0 0 0 0 0 0 0 0 10.2121 0 Q02153 GCYB1_HUMAN Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) GUCY1B1 GUC1B3 GUCSB3 GUCY1B3 Homo sapiens (Human) blood circulation [GO:0008015]; cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling [GO:0038060]; response to oxygen levels [GO:0070482] "cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]; presynaptic active zone cytoplasmic component [GO:0098831]" adenylate cyclase activity [GO:0004016]; cytidylate cyclase activity [GO:0047805]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; nitric oxide binding [GO:0070026]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] KNPFVYK;LTQELEILTDRLQLTLR;NPFVYKVETVGDK;TETTGEK 4 6.1 0.97562 -3.4059 0 0 0 0 0 0 12.0904 0 0 10.0447 0 0 Q02156 KPCE_HUMAN Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) PRKCE PKCE Homo sapiens (Human) "apoptotic process [GO:0006915]; cell division [GO:0051301]; cell-substrate adhesion [GO:0031589]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; cellular response to prostaglandin E stimulus [GO:0071380]; establishment of localization in cell [GO:0051649]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; locomotory exploration behavior [GO:0035641]; macrophage activation involved in immune response [GO:0002281]; MAPK cascade [GO:0000165]; mucus secretion [GO:0070254]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transmembrane transport [GO:1902306]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cellular glucuronidation [GO:2001031]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]; toxin catabolic process [GO:0009407]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]" cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] "14-3-3 protein binding [GO:0071889]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; ethanol binding [GO:0035276]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor activator activity [GO:0030546]" FMATYLR;ITNSGQR;VLADLGVTPDK 3 3.4 0.93697 -0.55088 0 0 0 0 0 0 0 7.58097 0 0 0 8.27501 Q02218 ODO1_HUMAN "2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)" OGDH Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hippocampus development [GO:0021766]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252] metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] LSGQDVER;LSGQDVERGTFSHR;QILLPFRKPLIIFTPKSLLR;QKFETPGIMQFTNEEKR;THLTELQRLLDTAFDLDVFKNFS 5 7.2 0.95643 -0.83946 0 0 0 0 0 10.2786 0 0 10.8307 0 5.47771 0 Q02221 CX6A2_HUMAN "Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M)" COX6A2 COX6A COX6AH Homo sapiens (Human) "generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491] GLASAAK 1 7.2 0.58945 0.1791 0 12.3688 12.214 0 0 0 0 0 0 0 0 0 Q02224 CENPE_HUMAN Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) CENPE Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; lateral attachment of mitotic spindle microtubules to kinetochore [GO:0099607]; metaphase chromosome alignment [GO:0051310]; microtubule plus-end directed mitotic chromosome migration [GO:0099606]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of protein kinase activity [GO:0045860]; regulation of mitotic metaphase/anaphase transition [GO:0030071] "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; spindle midzone [GO:0051233]" ATP binding [GO:0005524]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ADYDNLVLDYEQLR;AIHDIFQK;EALEVKHDQLKEHIR;EELKIAHIHLKEHQETIDELR;EEQFNIKQISEVQEK;ELENSLHEAKESAMHK;ELQKSFETERDHLR;ETLAKIQESQSKQEQSLNMK;GEPSNCEGSVK;KIFSLIQEK;LAEVEEK;LQEVLQSESDQLKENIKEIVAK;LTQILHENLEEMRSVTK;MERDQFIATLREMIAR;NAKEFEK;QLEEVSLETR;QQEIVAQEKNHAIK;RLQESHDEMKSVAK;TQELQEKTREVQER;VELLREK;VTGTASK 21 10.3 0.97825 -7.6795 11.736 11.5994 12.1498 0 10.4398 11.3017 10.2382 10.6129 12.6811 14.2721 0 0 Q02241 KIF23_HUMAN Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 Homo sapiens (Human) microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467] centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ESSRSHSVFNIK;LIEALEKR;LNRNGDYK;LQRQFSDKR;TTTIYEEDK;VRMIVCVNPKAEDYEENLQVMR 6 7.1 0.97495 -4.1139 7.6097 0 0 0 0 0 0 0 11.0238 0 11.5468 0 Q02241 KIF23_HUMAN Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 Homo sapiens (Human) microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467] centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ESSRSHSVFNIK;LIEALEKR;LQRQFSDKR;MITVQEFCK;TTTIYEEDK;VRMIVCVNPKAEDYEENLQVMR 6 10.3 0.91002 -0.3152 0 0 0 0 0 0 0 0 0 0 6.9377 0 Q02246 CNTN2_HUMAN Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) CNTN2 AXT TAG1 TAX1 Homo sapiens (Human) adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cerebral cortex GABAergic interneuron migration [GO:0021853]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite self-avoidance [GO:0070593]; establishment of localization in cell [GO:0051649]; establishment of protein localization to juxtaparanode region of axon [GO:0071206]; fat cell differentiation [GO:0045444]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; learning [GO:0007612]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of protein processing [GO:0010954]; presynaptic membrane organization [GO:0097090]; protein localization to juxtaparanode region of axon [GO:0071205]; protein processing [GO:0016485]; receptor internalization [GO:0031623]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of astrocyte differentiation [GO:0048710]; regulation of axon diameter [GO:0031133]; regulation of cell morphogenesis [GO:0022604]; regulation of neuronal synaptic plasticity [GO:0048168]; synapse organization [GO:0050808] axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; juxtaparanode region of axon [GO:0044224]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; side of membrane [GO:0098552]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632] ETIGDLTILNAQLRHGGK;LSLEDSGMYQCVAENK;SDEGKYTCFAENFMGK;TNVKETIGDLTILNAQLR;VEVLAGDLRFSK;VTVTPDGTLIIRNISRSDEGK;WLRNGEPLASQNR 7 9.1 0.97663 -1.4901 0 0 11.3905 0 7.1537 0 0 0 8.15107 10.3064 9.52841 7.32454 Q02297 NRG1_HUMAN "Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]" NRG1 GGF HGL HRGA NDF SMDF Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; brain development [GO:0007420]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell communication [GO:0007154]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; endocardial cell differentiation [GO:0060956]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB3 signaling pathway [GO:0038129]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary gland development [GO:0030879]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of secretion [GO:0051048]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; peripheral nervous system development [GO:0007422]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; sequestering of metal ion [GO:0051238]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] RQQGALDR;SGRPGPR 2 3.6 0.90919 -0.30079 0 0 0 0 0 10.4823 0 0 6.64847 0 0 0 Q02318 CP27A_HUMAN "Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" CYP27A1 CYP27 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; calcitriol biosynthetic process from calciol [GO:0036378]; cholesterol catabolic process [GO:0006707]; cholesterol metabolic process [GO:0008203]; sterol metabolic process [GO:0016125] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cholestanetetraol 26-dehydrogenase activity [GO:0047748]; cholesterol 26-hydroxylase activity [GO:0031073]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343] GAGRGLCPHGAR;YPVRNDMELWK 2 4.3 0.95521 -0.86583 10.6803 0 0 0 0 0 0 0 0 10.9058 0 0 Q02338 BDH_HUMAN "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)" BDH1 BDH SDR9C1 Homo sapiens (Human) steroid metabolic process [GO:0008202] intracellular membrane-bounded organelle [GO:0043231]; matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-hydroxybutyrate dehydrogenase activity [GO:0003858] GFLVFAGCLMKDK;LPGKTLSACDR;VVNISSMLGR 3 9.9 0.97277 -2.6643 0 0 0 0 0 9.36918 0 0 0 11.6266 0 0 Q02363 ID2_HUMAN DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) ID2 BHLHB26 Homo sapiens (Human) bundle of His development [GO:0003166]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; entrainment of circadian clock by photoperiod [GO:0043153]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; heart development [GO:0007507]; locomotor rhythm [GO:0045475]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; olfactory bulb development [GO:0021772]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of blood pressure [GO:0045777]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of circadian rhythm [GO:0042752]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lipid metabolic process [GO:0019216]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325] NSLSDHSLGISR;TPVDDPMSLLYNMNDCYSK 2 23.1 0.89189 -0.21645 0 0 0 0 8.67444 0 9.89936 0 0 0 5.35283 0 Q02383 SEMG2_HUMAN Semenogelin-2 (Semenogelin II) (SGII) SEMG2 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; coagulation [GO:0050817]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634] protease binding [GO:0002020]; zinc ion binding [GO:0008270] ISYPSSR;LNSGEKDVQK;MKSIILFVLSLLLILEK;RLNYGGK;SIILFVLSLLLILEK 5 7 0.97946 -1.898 9.92487 9.14387 0 0 0 0 0 0 9.49466 0 9.85037 7.86313 Q02386 ZNF45_HUMAN Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) ZNF45 KOX5 ZNF13 Homo sapiens (Human) nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] CEECGKGFCR;SFSQRSHLPHHQR 2 4.8 0.95315 -0.67401 0 0 2.72718 0 0 4.57924 10.5125 0 0 0 0 0 Q02388 CO7A1_HUMAN Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) COL7A1 Homo sapiens (Human) cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen type VII trimer [GO:0005590]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] AGERGLR;GERGEKGDVGSAGLK;GYRLEWR;ITWVGVTGATAYR;LLETAGIKASALR;LVDTGPGAREK;RETGLEPPQK;SVPGATGYR;VPSIELR;VSWHSAHGPEK 10 3.5 0.97854 -7.472 12.1419 0 0 11.6334 10.1787 11.3824 11.4394 11.364 11.7548 11.0735 11.996 0 Q02410 APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) APBA1 MINT1 X11 Homo sapiens (Human) axo-dendritic transport [GO:0008088]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021] amyloid-beta binding [GO:0001540] AVGPAGGGEAGQR;AVGPAGGGEAGQRYSK;EAEFAPYPR 3 3 0.97586 -1.4486 0 11.4539 0 11.3766 0 0 0 0 0 0 0 12.4027 Q02413 DSG1_HUMAN Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen) DSG1 CDHF4 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; protein stabilization [GO:0050821]; response to progesterone [GO:0032570] apical plasma membrane [GO:0016324]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; toxic substance binding [GO:0015643] ECREGGLNMNFMESYFCQK 1 1.8 0.82499 -0.020545 0 0 0 0 6.3922 0 0 0 0 0 0 0 Q02487 DSC2_HUMAN Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) DSC2 CDHF2 DSC3 Homo sapiens (Human) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell-cardiac muscle cell adhesion [GO:0086042]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cellular response to starvation [GO:0009267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasmic vesicle [GO:0031410]; desmosome [GO:0030057]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083] DLVNTANWR;IGGGGVQLGK;LDAEKLVGR;SLDREAETIK 4 4.2 0.98127 -1.7888 0 0 0 0 11.4358 0 0 0 3.34085 0 0 12.2886 Q02509 OC90_HUMAN Otoconin-90 (Oc90) (Phospholipase A2 homolog) OC90 PLA2L Homo sapiens (Human) arachidonate secretion [GO:0050482]; lipid catabolic process [GO:0016042]; otolith mineralization [GO:0045299]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198] CPEEFESYGCYCGQEGR;CPEEFESYGCYCGQEGRGEPR 2 4.4 0.71353 0.14449 0 0 3.37323 5.40613 0 0 0 0 0 0 0 0 Q02535 ID3_HUMAN DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) ID3 1R21 BHLHB25 HEIR1 Homo sapiens (Human) cellular response to leptomycin B [GO:0072750]; central nervous system development [GO:0007417]; circadian rhythm [GO:0007623]; epithelial cell differentiation [GO:0030855]; heart development [GO:0007507]; metanephros development [GO:0001656]; muscle organ development [GO:0007517]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of DNA replication [GO:0006275] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bHLH transcription factor binding [GO:0043425]; leptomycin B binding [GO:1901707]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] SLAIARGR 1 6.7 0.91292 -0.33804 0 0 0 7.72547 0 0 0 0 7.49506 7.48728 0 0 Q02543 RL18A_HUMAN Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) RPL18A Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] CHTPPLYRMRIFAPNHVVAK;IFAPNHVVAK;VEEIAASK 3 15.9 0.056507 0.46387 0 0 0 0 7.1808 0 0 0 0 0 10.851 9.3347 Q02556 IRF8_HUMAN Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) IRF8 ICSBP1 Homo sapiens (Human) autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; dendritic cell differentiation [GO:0097028]; follicular B cell differentiation [GO:0002316]; germinal center B cell differentiation [GO:0002314]; immune response [GO:0006955]; immune system process [GO:0002376]; myeloid cell differentiation [GO:0030099]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phagocytosis [GO:0006909]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ELQQFYNSQGRLPDGR;SEIDELIKEPSVDDYMGMIK;SPDFEEVTDR;VFCSGNAVVCKGRPNK 4 14.6 0.93858 -0.57279 0 0 0 10.2584 8.49526 6.21243 0 0 0 13.6319 13.4298 0 Q02575 HEN1_HUMAN Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1) NHLH1 BHLHA35 HEN1 Homo sapiens (Human) cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" RATAKYR;VEAFNLAFAELR;VEAFNLAFAELRK 3 15 0.9808 -1.7323 0 0 0 0 9.71119 2.98008 0 8.74059 0 0 0 0 Q02641 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) CACNB1 CACNLB1 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514] L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] calcium channel regulator activity [GO:0005246]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] EAERQALAQLEKAK 1 2.3 0.76412 0.062505 0 0 0 8.32039 0 0 0 0 0 0 0 0 Q02643 GHRHR_HUMAN Growth hormone-releasing hormone receptor (GHRH receptor) (Growth hormone-releasing factor receptor) (GRF receptor) (GRFR) GHRHR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; growth hormone secretion [GO:0030252]; hormone metabolic process [GO:0042445]; lactation [GO:0007595]; multicellular organismal reproductive process [GO:0048609]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of intracellular steroid hormone receptor signaling pathway [GO:0033143]; regulation of protein metabolic process [GO:0051246]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; somatotropin secreting cell development [GO:0060133] cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; growth factor binding [GO:0019838]; growth hormone-releasing hormone receptor activity [GO:0016520]; peptide hormone binding [GO:0017046] GPIVLSVGVNFGLFLNIIRILVRK;NYVHTQLFTTFILK 2 9 0.064784 0.43116 0 7.62432 0 0 0 7.62593 2.75196 0 0 0 0 0 Q02747 GUC2A_HUMAN Guanylin (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Guanylate cyclase-activating protein I) (GCAP-I) [Cleaved into: HMW-guanylin; Guanylin] GUCA2A GUCA2 Homo sapiens (Human) extracellular region [GO:0005576] guanylate cyclase activator activity [GO:0030250]; hormone activity [GO:0005179] LKDLQEPQEPR 1 9.6 0.9216 -0.44283 0 0 6.60795 0 0 0 0 0 0 0 0 0 Q02750 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) MAP2K1 MEK1 PRKMK1 Homo sapiens (Human) Bergmann glial cell differentiation [GO:0060020]; cell motility [GO:0048870]; cellular senescence [GO:0090398]; cerebellar cortex formation [GO:0021697]; chemotaxis [GO:0006935]; endodermal cell differentiation [GO:0035987]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; keratinocyte differentiation [GO:0030216]; labyrinthine layer development [GO:0060711]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; placenta blood vessel development [GO:0060674]; positive regulation of axonogenesis [GO:0050772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; type B pancreatic cell proliferation [GO:0044342] centrosome [GO:0005813]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; scaffold protein binding [GO:0097110] IPEQILGK;IPEQILGKVSIAVIK;KLIHLEIKPAIRNQIIR;LIHLEIKPAIRNQIIR 4 8.1 0.95443 -0.80144 8.51381 0 3.72923 0 0 4.25293 0 0 0 11.0945 10.7602 0 Q02763 TIE2_HUMAN Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor activity [GO:0038023]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CSCNNGEMCDR;CSCNNGEMCDRFQGCLCSPGWQGLQCER;GDNVNISFKKVLIK 3 3.7 0.93338 -0.4976 0 0 0 0 0 0 11.136 10.8499 5.46865 0 6.05648 10.0979 Q02779 M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) MAP3K10 MLK2 MST Homo sapiens (Human) apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737] ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor activity [GO:0003714] DLLDFPR;EGGSHISLPSGFEHK 2 2.3 0.93524 -0.53118 0 0 0 0 0 8.55105 0 7.08746 0 0 0 0 Q02790 FKBP4_HUMAN "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 FKBP52 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; chaperone-mediated protein folding [GO:0061077]; copper ion transport [GO:0006825]; embryo implantation [GO:0007566]; male sex differentiation [GO:0046661]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; prostate gland development [GO:0030850]; protein folding [GO:0006457]; protein-containing complex localization [GO:0031503]; steroid hormone receptor complex assembly [GO:0006463] axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; copper-dependent protein binding [GO:0032767]; FK506 binding [GO:0005528]; GTP binding [GO:0005525]; heat shock protein binding [GO:0031072]; nuclear glucocorticoid receptor binding [GO:0035259]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; tau protein binding [GO:0048156] ALELDSNNEK;GEDLTEEEDGGIIRR;QALLQYK;SNTAGSQSQVETEA;VIKREGTGTEMPMIGDR;VLQLYPNNK 6 15.7 0 6.7808 0 0 7.7387 7.34784 0 7.53356 12.1571 7.65828 11.9579 9.00442 8.82286 0 Q02809 PLOD1_HUMAN "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)" PLOD1 LLH PLOD Homo sapiens (Human) collagen fibril organization [GO:0030199]; epidermis development [GO:0008544]; peptidyl-lysine hydroxylation [GO:0017185]; response to hypoxia [GO:0001666] catalytic complex [GO:1902494]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum membrane [GO:0030867] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475] LLRLHYPQKHMR;LTHYHEGLPTTR 2 3.3 0.97944 -1.8918 0 11.8957 0 8.6291 8.23161 8.5862 0 0 0 0 0 0 Q02817 MUC2_HUMAN Mucin-2 (MUC-2) (Intestinal mucin-2) MUC2 SMUC Homo sapiens (Human) detoxification of copper ion [GO:0010273]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; inner mucus layer [GO:0070702]; outer mucus layer [GO:0070703]; plasma membrane [GO:0005886] cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136] AQALDHSCSCCK;DCTPSPLCQLIK;LCCLWSDWINEDHPSSGSDDGDR;MDGCFCPEGTVYDDIGDSGCVPVSQCHCR;NNCTFFSCVK;TCGCVGPDNVPREFGEHFEFDCKNCVCLEGGSGIICQPK;VDCNTCTCK 7 2.5 0.91811 -0.40498 0 14.503 7.42164 7.20984 0 0 14.0533 0 6.78581 0 0 0 Q02818 NUCB1_HUMAN Nucleobindin-1 (CALNUC) NUCB1 NUC Homo sapiens (Human) small GTPase-mediated signal transduction [GO:0007264] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085] DLAQYDAAHHEEFKRYEMLK;ELQQAVLHMEQRK;GTLLLLPLLLLLLLR;GTLLLLPLLLLLLLRAVLAVPLERGAPNK;LSRELDFVSHHVR 5 16.3 0.98182 -1.5844 11.9331 0 0 10.0217 8.32647 3.21036 0 11.4665 0 9.87464 3.96255 0 Q02846 GUC2D_HUMAN "Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)" GUCY2D CORD6 GUC1A4 GUC2D RETGC RETGC1 Homo sapiens (Human) cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] GAEDTFWLVGR;LDWMFKSSLLLDLIK 2 2.4 0.89797 -0.23543 0 0 0 8.83384 0 0 0 0 0 0 0 0 Q02878 RL6_HUMAN Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) RPL6 TXREB1 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; regulation of DNA-templated transcription [GO:0006355]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; rough endoplasmic reticulum [GO:0005791] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AIPQLQGYLR;ASITPGTILIILTGR;AVDSQILPK;FVIATSTK;IDISNVK;KLRASITPGTILIILTGR;QLASGLLLVTGPLVLNR;QLASGLLLVTGPLVLNRVPLRR;SVFALTNGIYPHK;SVFALTNGIYPHKLVF;VLATVTKPVGGDK;YEITEQR;YYPTEDVPR 13 41.3 0 16.368 8.32233 10.4258 8.10418 0 10.4993 9.49536 10.4482 12.8272 11.8998 12.8799 13.5396 9.57344 Q02880 TOP2B_HUMAN "DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)" TOP2B Homo sapiens (Human) axonogenesis [GO:0007409]; B cell differentiation [GO:0030183]; cellular response to ATP [GO:0071318]; cellular response to hydrogen peroxide [GO:0070301]; cellular senescence [GO:0090398]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]" EKVEELIKQR;FILEKIQGK;FTVETACK;FTVETACKEYKHSFK;KYETVQDILKEFFDLR;LLFPAVDDNLLK;QIMENAEINNIIK;SLAVSGLGVIGRDR 8 5.5 0.97478 -3.9073 6.2807 0 8.54963 11.2962 5.73847 0 10.5677 8.34784 7.40633 10.4501 0 0 Q02928 CP4AB_HUMAN Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4A11 CYP4A2 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; leukotriene metabolic process [GO:0006691]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid metabolic process [GO:0001676]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; arachidonate monooxygenase activity [GO:0008391]; arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497] AQLQKEGELEK;IPIPIARLVLKSK;LLGDVSGILQAASLLILLLLLIK;NCIGKQFAMNELKVATALTLLR;VILGRSDPK 5 15 0.96434 -1.1655 0 0 0 0 0 5.72797 0 8.13067 0 8.96913 0 0 Q02930 CREB5_HUMAN Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa) CREB5 CREBPA Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]" AAATRCRQK;MIHRHKHEMTLK;TDLNPIL 3 5.9 0.97376 -2.4627 0 0 0 0 8.27761 0 0 0 0 10.8016 0 0 Q02952 AKA12_HUMAN A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) AKAP12 AKAP250 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatic stellate cell activation [GO:0035733]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of vascular permeability [GO:0043116]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hepatic stellate cell migration [GO:0061870]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte apoptotic process [GO:1900143]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein kinase C signaling [GO:0090036]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase binding [GO:0008179]; calmodulin binding [GO:0005516]; protein kinase A binding [GO:0051018] AITPQAQEELQK;KDKTEKPDTVQLLTVK;QSTEKPEETLK;VHSESDKAITPQAQEELQKQER 4 2.7 0.88843 -0.20189 0 0 0 0 0 0 0 5.16144 0 10.57 6.89105 0 Q02978 M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) SLC25A11 SLC20A4 Homo sapiens (Human) gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; malate-aspartate shuttle [GO:0043490]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transmembrane transport [GO:1902358]; thiosulfate transport [GO:0015709] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117] AATASAGAGGIDGKPR;NRMQLSGEGAK 2 8.6 0 2.0315 0 7.46948 0 0 0 0 0 10.5926 0 0 9.49667 0 Q02978 M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) SLC25A11 SLC20A4 Homo sapiens (Human) gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; malate-aspartate shuttle [GO:0043490]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transmembrane transport [GO:1902358]; thiosulfate transport [GO:0015709] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117] AATASAGAGGIDGKPR;FLFGGLAGLSAGLLRQATYTTTR 2 14.8 0.83558 -0.029624 0 0 0 0 0 0 0 0 0 9.22913 0 0 Q03001 DYST_HUMAN Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] ADQLVERWQNVHVQIDNRLR;CAIDEEFNEMR;DGGKVDTSATHR;DIEIVNVQDSEYVK;DLEGIGK;DLIDPCTSEKVSLIDMVQR;DPQGNGSDLIKGRDGK;EEIEPLQGK;EGEKIATTAEPADKVK;ELDLFTYLK;ELKVHYETALAESEKK;GASPNRSTSVSSQAAQAASPQVPATTTPK;HGDKMTDEERNELEK;ISSEEISTK;ITGVFELMR;KQQLDGALRQAK;LVNCEPIGTQASKLEEQIAQHK;QKISSEEISTK;SIDELNSAWDSLNKAWK;SLGAKHSVYDTTNR;SLMQKGQQMLAR;STIANLMGKAKTIIQLKPR;TAEVLLDARGSLLPAKNDIQK;VKAQHEK;VSLIDMVQR;WSLKTPEIQK;YEDLSKSVNER;YFSQKQDVVLIK;YKEQVETLWPWIDK;YYRDTYHPLDDWIQQVETTQRK 30 5.4 0.97866 -10.017 13.5533 11.2231 10.3455 10.715 0 9.14784 12.0408 4.35029 12.9969 15.2987 11.4102 11.3848 Q03001 DYST_HUMAN Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] SLEKGGFPEDPPK 1 1.4 0.88198 -0.16629 0 0 0 0 7.70356 0 0 0 0 0 0 7.35764 Q03001 DYST_HUMAN Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] ADQLVERWQNVHVQIDNRLR;AHAVAEK;DLEGIGK;ELERQLQQYR;ISVLKASR;LQREVDR;NIICPQTK;NIICPQTKR;NLNAELNASKEEKR;NYQLELESLNHEKGK;QKCDQQNIIIQNTK;QVAEKQLK;STIANLMGKAKTIIQLKPR;VQDELHLK;VRQLTIEAEAK;YYRDTYHPLDDWIQQVETTQRK 16 6.8 0.9782 -7.831 12.4547 0 11.7958 11.887 10.3112 0 9.91952 13.3195 0 0 13.2698 6.56592 Q03052 PO3F1_HUMAN "POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP)" POU3F1 OCT6 OTF6 Homo sapiens (Human) axon ensheathment [GO:0008366]; forebrain development [GO:0030900]; keratinocyte differentiation [GO:0030216]; myelination in peripheral nervous system [GO:0022011]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AGGGGTGR 1 1.8 0.746 0.10231 0 0 9.64451 0 0 10.5674 0 0 0 0 0 0 Q03060 CREM_HUMAN cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) CREM Homo sapiens (Human) cell differentiation [GO:0030154]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] "cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" WWHQHNLCFR 1 4.6 0.89709 -0.2358 0 0 0 0 0 0 9.23671 0 0 0 0 0 Q03060 CREM_HUMAN cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) CREM Homo sapiens (Human) cell differentiation [GO:0030154]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] ATF4-CREB1 transcription factor complex [GO:1990589]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] "cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" NREAARECR;QMTMETVESQHDGSITASLTESK;VAVLENQNK 3 11.8 0.88598 -0.1807 0 0 0 10.9025 9.73232 0 0 0 0 6.749 0 0 Q03111 ENL_HUMAN Protein ENL (YEATS domain-containing protein 1) MLLT1 ENL LTG19 YEATS1 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577] DSESKSSSKELER;ELEREQAK;KKPTTEGFTHDWMVFVR 3 6.1 0.96351 -1.0884 0 0 7.15076 0 0 0 0 0 0 8.21018 0 0 Q03113 GNA12_HUMAN Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) GNA12 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; blood coagulation [GO:0007596]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] D5 dopamine receptor binding [GO:0031752]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase activator activity [GO:0072542] DTIFDNILKGSR;GIVEHDFVIK;QMRIIHGREFDQK;RLVKILLLGAGESGK;YFLDNLDR;YLVQCFDRKR 6 17.8 0.97485 -4.057 0 10.9595 0 0 9.41762 0 12.8993 0 0 0 0 0 Q03154 ACY1_HUMAN Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) ACY1 Homo sapiens (Human) amino acid metabolic process [GO:0006520] cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminoacylase activity [GO:0004046]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] VTSTGRPGHASR 1 2.9 0.80431 0.01253 0 0 0 0 0 0 0 9.55968 0 0 0 0 Q03164 KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; exploration behavior [GO:0035640]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; methylation [GO:0032259]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; protein modification process [GO:0036211]; protein-containing complex assembly [GO:0065003]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]; visual learning [GO:0008542] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; protein-cysteine methyltransferase activity [GO:0106363]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] CYDDDDYESK;CYDDDDYESKMMQCGKCDR;GEVVPENGFEVFRR;GLGGAPR;IDRPEDAGEK;KVAPRPSIPVKQKPK;LASHNLFR;LFPIGYQCSR;QDDQQPLDLEGVKRK;RKVFSPIR 10 2.7 0.98087 -2.0311 4.4547 0 10.1678 0 4.9781 6.24692 6.83441 0 0 8.54805 8.59548 8.50668 Q03167 TGBR3_HUMAN Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) TGFBR3 Homo sapiens (Human) animal organ regeneration [GO:0031100]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell migration [GO:0016477]; definitive erythrocyte differentiation [GO:0060318]; definitive hemopoiesis [GO:0060216]; epicardium-derived cardiac fibroblast cell development [GO:0060939]; epithelial to mesenchymal transition [GO:0001837]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; heart trabecula morphogenesis [GO:0061384]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; muscular septum morphogenesis [GO:0003150]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix assembly [GO:1901202]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; secondary palate development [GO:0062009]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; fibroblast growth factor binding [GO:0017134]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; PDZ domain binding [GO:0030165]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type III [GO:0070123]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane signaling receptor activity [GO:0004888]; type II transforming growth factor beta receptor binding [GO:0005114]" KEYGAVTSFTELK;RVHFPIPQADMDKK 2 3.2 0.74558 0.10068 0 9.98342 0 0 0 0 0 0 0 6.55793 0 0 Q03169 TNAP2_HUMAN Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) TNFAIP2 Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; exocyst localization [GO:0051601]; exocytosis [GO:0006887] exocyst [GO:0000145]; extracellular space [GO:0005615] SNARE binding [GO:0000149] ELMDRALELEAR 1 1.8 0.9238 -0.44813 0 0 0 0 4.79244 0 0 0 0 0 0 0 Q03188 CENPC_HUMAN Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) CENPC CENPC1 ICEN7 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; spindle attachment to meiosis I kinetochore [GO:0051455] "condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" centromeric DNA binding [GO:0019237]; DNA binding [GO:0003677]; identical protein binding [GO:0042802] FLNAEGSGGIVGHDEISR;IHHKLVLPSNTPNVR;LNFDDKVMLK;NDVDDEEVHGSSDDSK;TISPAESTALLQGRK;TLDTPFFSTGK 6 9 0.95511 -0.78882 0 0 0 0 0 0 10.5863 0 10.0745 8.12743 8.67698 0 Q03188 CENPC_HUMAN Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) CENPC CENPC1 ICEN7 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; spindle attachment to meiosis I kinetochore [GO:0051455] "condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" centromeric DNA binding [GO:0019237]; DNA binding [GO:0003677]; identical protein binding [GO:0042802] LNFDDKVMLK;RPSDWWVVKSEESCLKC;TISPAESTALLQGRK 3 7.7 0.85378 -0.08043 0 0 0 0 0 0 0 0 0 0 0 7.18686 Q03252 LMNB2_HUMAN Lamin-B2 LMNB2 LMN2 Homo sapiens (Human) heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435] intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200] AGGPATPLSPTR;ATSSSSGSLSATGR;EGELTVAQGR;ISEKEEVTTR;LLEGEEER;LSPSPSSR 6 10 0 4.9481 12.2281 0 0 9.97499 0 0 7.91462 0 11.5392 12.4853 10.5635 0 Q03426 KIME_HUMAN Mevalonate kinase (MK) (EC 2.7.1.36) MVK Homo sapiens (Human) "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; negative regulation of inflammatory response [GO:0050728]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; mevalonate kinase activity [GO:0004496] EVAGLPDDCAVTER 1 3.5 0.7845 0.020412 0 0 0 0 0 0 0 0 10.0672 0 0 0 Q03468 ERCC6_HUMAN DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) ERCC6 CSB Homo sapiens (Human) "base-excision repair [GO:0006284]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; multicellular organism growth [GO:0035264]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; pyrimidine dimer repair [GO:0006290]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to gamma radiation [GO:0010332]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription-coupled nucleotide-excision repair [GO:0006283]" B-WICH complex [GO:0110016]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; transcription elongation factor complex [GO:0008023] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; protein tyrosine kinase activator activity [GO:0030296]; RNA polymerase binding [GO:0070063]" LDSVKRQK;LEDDSEESDAEFDEGFK;NLCTFHR;SVGDGLSTSAVGCASAAPRR;VVIYDPDWNPSTDTQAR 5 4.6 0.981 -1.6901 0 0 9.2268 12.0406 5.1304 6.11836 0 9.43981 0 7.98743 0 0 Q03518 TAP1_HUMAN Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4) TAP1 ABCB2 PSF1 RING4 Y3 Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; cytosol to endoplasmic reticulum transport [GO:0046967]; defense response [GO:0006952]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] centriolar satellite [GO:0034451]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825] ABC-type peptide antigen transporter activity [GO:0015433]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide transmembrane transporter activity [GO:1904680]; protein homodimerization activity [GO:0042803]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979] MASSRCPAPR 1 1.3 0.97463 -1.3928 0 0 0 11.5029 11.4699 0 0 0 0 0 0 0 Q03519 TAP2_HUMAN Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) TAP2 ABCB3 PSF2 RING11 Y1 Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cytosol to endoplasmic reticulum transport [GO:0046967]; peptide antigen transport [GO:0046968]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein transport [GO:0015031]; response to molecule of bacterial origin [GO:0002237]; T cell mediated cytotoxicity [GO:0001913]; transmembrane transport [GO:0055085]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear speck [GO:0016607]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825] ABC-type peptide antigen transporter activity [GO:0015433]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide transmembrane transporter activity [GO:1904680]; TAP1 binding [GO:0046978]; tapasin binding [GO:0046980] HQEVLREIQDAVAR;TVLVIAHRLQTVQR 2 4.1 0.9556 -0.81044 8.71008 0 0 0 0 0 0 0 0 0 0 0 Q03701 CEBPZ_HUMAN CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) CEBPZ CBF2 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] CCAAT-binding factor complex [GO:0016602]; nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] AIVSSGTLGDR;DIRHLPVNSK;FLDRFVYRNPKPHK;FVYRNPKPHKGK;KKDVESK;LILWYFEHQLK;QLRWEAER;TSVNKVKNK 8 6.8 0.97323 -2.8868 0 0 0 0 8.81092 8.22081 10.6156 11.9369 0 12.3102 10.1198 0 Q03721 KCNC4_HUMAN Voltage-gated potassium channel KCNC4 (KSHIIIC) (Potassium voltage-gated channel subfamily C member 4) (Voltage-gated potassium channel subunit Kv3.4) KCNC4 C1orf30 Homo sapiens (Human) action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; metal ion binding [GO:0046872]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249] AGEIRGWEGK;HFVGLRVLGHTLR;IFKLTRHFVGLR;ISSVCVSSYRGR;LTRHFVGLRVLGHTLR;MISSVCVSSYR;NVTEILRVGNITSVHFR;VVRFVRILR 8 11.7 0.97248 -2.7815 8.60511 0 10.7992 0 6.67835 0 0 8.78669 9.47111 9.18987 10.5681 7.9276 Q03923 ZNF85_HUMAN Zinc finger protein 85 (Zinc finger protein HPF4) (Zinc finger protein HTF1) ZNF85 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GCESMDECK;GCESMDECKMHK 2 2 0.97681 -2.208 8.40863 8.92799 8.99839 0 0 0 0 0 0 0 5.37448 0 Q03924 ZN117_HUMAN Zinc finger protein 117 (Provirus-linked krueppel) (h-PLK) (Zinc finger protein HPF9) ZNF117 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AFNQASK;AFNQTSHLIRHKR;IIHTGENPHKCR;QYKCDECGK 4 8.5 0.97497 -1.431 0 0 10.4782 0 9.91536 0 4.40579 0 8.85247 0 0 0 Q03933 HSF2_HUMAN Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2) HSF2 HSTF2 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" IISSAQK;VSSSKPEENKIR 2 3.5 0.82953 -0.022907 12.4964 0 0 8.29953 0 0 0 0 0 0 0 0 Q03938 ZNF90_HUMAN Zinc finger protein 90 (Zinc finger protein HTF9) ZNF90 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" IHTGEKRYK;ISHTEEKLYK;RYKCEDCGK;VIVTRYEKR 4 8.2 0.97561 -2.3153 0 7.04341 0 0 0 0 10.9049 0 0 7.83029 10.1635 10.427 Q03989 ARI5A_HUMAN AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) ARID5A MRF1 Homo sapiens (Human) cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; chondrocyte differentiation [GO:0002062]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of protein acetylation [GO:1901985]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA stem-loop binding [GO:0035613]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] IYKAVEK;MDQMMPGKTK 2 2.9 0.98068 -1.8004 0 10.3581 0 0 0 0 10.7796 0 0 0 0 0 Q04206 TF65_HUMAN Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) RELA NFKB3 Homo sapiens (Human) acetaldehyde metabolic process [GO:0006117]; animal organ morphogenesis [GO:0009887]; antiviral innate immune response [GO:0140374]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to angiotensin [GO:1904385]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to nicotine [GO:0071316]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; chromatin organization [GO:0006325]; cytokine-mediated signaling pathway [GO:0019221]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; hair follicle development [GO:0001942]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuropeptide signaling pathway [GO:0007218]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postsynapse to nucleus signaling pathway [GO:0099527]; prolactin signaling pathway [GO:0038161]; protein catabolic process [GO:0030163]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to cobalamin [GO:0033590]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to ischemia [GO:0002931]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor signaling pathway [GO:0038084] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; NF-kappaB complex [GO:0071159]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "actinin binding [GO:0042805]; ankyrin repeat binding [GO:0071532]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; peptide binding [GO:0042277]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]" CIHSFQNLGIQCVK 1 2.5 0.78925 0.017107 0 0 0 0 0 8.14603 0 0 0 0 0 0 Q04323 UBXN1_HUMAN UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein) UBXN1 SAKS1 Homo sapiens (Human) negative regulation of ERAD pathway [GO:1904293]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome regulatory particle binding [GO:1904855]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] QRLQEDEMRR 1 3.4 0.95973 -1.0448 0 0 9.13437 0 0 0 0 0 5.65183 0 0 0 Q04446 GLGB_HUMAN "1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)" GBE1 Homo sapiens (Human) generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; negative regulation of neuron apoptotic process [GO:0043524] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "1,4-alpha-glucan branching enzyme activity [GO:0003844]; carbohydrate binding [GO:0030246]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" AAPMTPAARPEDYEAALNAALADVPELAR;VALILQNVDLPN;VGTALPGKFK 3 7.3 0 18.43 0 0 0 0 0 0 9.4951 0 6.75409 9.42735 9.38619 0 Q04609 FOLH1_HUMAN Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) FOLH1 FOLH NAALAD1 PSM PSMA GIG27 Homo sapiens (Human) C-terminal protein deglutamylation [GO:0035609]; folic acid-containing compound metabolic process [GO:0006760]; proteolysis [GO:0006508] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] Ac-Asp-Glu binding [GO:1904492]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; tetrahydrofolyl-poly(glutamate) polymer binding [GO:1904493] KSPSPEFSGMPR;SNPIVLRMMNDQLMFLER 2 4 0.92864 -0.47044 0 0 0 0 10.6313 0 0 0 0 7.27184 0 0 Q04637 IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) behavioral fear response [GO:0001662]; cap-dependent translational initiation [GO:0002191]; cellular response to nutrient levels [GO:0031669]; energy homeostasis [GO:0097009]; lung development [GO:0030324]; macromolecule biosynthetic process [GO:0009059]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of autophagy [GO:0010507]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of eukaryotic translation initiation factor 4F complex assembly [GO:1905537]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of mRNA cap binding [GO:1905612]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cellular response to stress [GO:0080135]; regulation of presynapse assembly [GO:1905606]; regulation of translational initiation [GO:0006446]; response to ethanol [GO:0045471]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribosome [GO:0005840] "ATP binding [GO:0005524]; eukaryotic initiation factor 4E binding [GO:0008190]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]" AASLLLEILGLLCKSMGPKK;AASLTEDRDR;DKDDDEVFEK;EAALPPVSPLK;EAVGDLLDAFK;EGSSNQR;GGPGGELPR;GVIDLIFEK;LLTTIGK 9 5.9 0.98113 -2.0284 0 12.2168 0 0 0 9.53829 6.74806 7.09497 7.82528 0 9.07283 0 Q04656 ATP7A_HUMAN Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP7A MC1 MNK Homo sapiens (Human) blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; catecholamine metabolic process [GO:0006584]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to cadmium ion [GO:0071276]; cellular response to cobalt ion [GO:0071279]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to lead ion [GO:0071284]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; collagen fibril organization [GO:0030199]; copper ion export [GO:0060003]; copper ion homeostasis [GO:0055070]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; dopamine metabolic process [GO:0042417]; elastic fiber assembly [GO:0048251]; elastin biosynthetic process [GO:0051542]; epinephrine metabolic process [GO:0042414]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; lactation [GO:0007595]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; negative regulation of iron ion transmembrane transport [GO:0034760]; neuron projection morphogenesis [GO:0048812]; norepinephrine metabolic process [GO:0042415]; peptidyl-lysine modification [GO:0018205]; pigmentation [GO:0043473]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell size [GO:0045793]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of response to wounding [GO:1903036]; positive regulation of tyrosinase activity [GO:0032773]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; pyramidal neuron development [GO:0021860]; regulation of oxidative phosphorylation [GO:0002082]; removal of superoxide radicals [GO:0019430]; response to iron(III) ion [GO:0010041]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]; serotonin metabolic process [GO:0042428]; skin development [GO:0043588]; T-helper cell differentiation [GO:0042093]; tryptophan metabolic process [GO:0006568] apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; microvillus [GO:0005902]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase copper chaperone activity [GO:0016532] ASINSLLSDK;IGKLQGVQRIK;SMGLEVVLMTGDNSK;WLEHIAKGKTSEALAK;YLKLGAIDVERLK 5 4.3 0.94004 -0.57873 12.8809 12.6964 0 0 0 0 8.72785 0 0 0 0 8.03271 Q04671 P_HUMAN P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog) OCA2 D15S12 P Homo sapiens (Human) cell population proliferation [GO:0008283]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; melanocyte differentiation [GO:0030318]; spermatid development [GO:0007286] endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162] chloride channel activity [GO:0005254] EETAVRRLLLGK;YLLSREVSGLSASASSEK 2 3.6 0.87341 -0.115 5.01074 0 0 0 0 0 0 0 0 7.69947 0 0 Q04695 K1C17_HUMAN "Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)" KRT17 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; positive regulation of cell growth [GO:0030307]; positive regulation of hair follicle development [GO:0051798]; positive regulation of translation [GO:0045727] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] ALEEANTELEVK;ASLEGNLAETENR;ATMQNLNDR;DAEDWFFSK;DYSQYYR;EVATNSELVQSGK;FETEQALR;GQVGGEINVEMDAAPGVDLSR;GSSGLGGGSSR;ILNEMRDQYEK;KDAEDWFFSK;KEPVTTR;LAADDFR;LASYLDK;LASYLDKVR;LEQEIATYR;LEQEIATYRR;LLEGEDAHLTQYK;LLEGEDAHLTQYKK;LSGGLGAGSCR;NHEEEMNALR;QFTSSSSIK;QFTSSSSIKGSSGLGGGSSRTSCR;SEISELR;TIEELQNK;TIVEEVQDGK;TIVEEVQDGKVISSR;TKFETEQALR;TMQALEIELQSQLSMK;VLDELTLAR 30 58.3 0 190.53 15.7469 15.6814 15.5025 11.9044 10.6036 12.4651 16.5448 15.963 16.4584 16.6461 16.3075 10.1906 Q04721 NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] NOTCH2 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular signal transduction [GO:0035556]; intrahepatic bile duct development [GO:0035622]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; podocyte development [GO:0072015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060] cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "calcium ion binding [GO:0005509]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; NF-kappaB binding [GO:0051059]; signaling receptor activity [GO:0038023]" TQLLYLLAVAVVIILFIILLGVIMAKR;VASFSCMCPEGK 2 1.6 0.36532 0.23213 0 0 0 0 0 0 0 0 6.84975 4.43576 0 0 Q04726 TLE3_HUMAN Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) TLE3 KIAA1547 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] IKDEFQFLQAQYHSLKVEYDK;VEYDKLANEK 2 3.4 0.9651 -1.2171 10.2286 0 0 0 0 0 0 0 0 0 11.2699 0 Q04727 TLE4_HUMAN Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) TLE4 GRG4 KIAA1261 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Wnt signaling pathway [GO:0016055] beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714] IKAELTSSAPACYALAISPDSK;SPVVGFDPHHHMR 2 4.5 0.88184 -0.15936 0 0 6.21775 0 0 0 0 0 8.10003 0 12.3048 0 Q04741 EMX1_HUMAN Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1) EMX1 Homo sapiens (Human) brain development [GO:0007420]; brain morphogenesis [GO:0048854]; central nervous system development [GO:0007417]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron projection extension [GO:1990138]; post-embryonic development [GO:0009791]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410] chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AAAPGRGALPR;LERAFEKNHYVVGAER 2 9.3 0.89733 -0.25554 9.7255 0 11.1723 0 0 0 0 0 0 0 0 0 Q04743 EMX2_HUMAN Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2) EMX2 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; central nervous system development [GO:0007417]; cerebral cortex regionalization [GO:0021796]; dentate gyrus development [GO:0021542]; forebrain cell migration [GO:0021885]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; stereocilium bundle organization [GO:0160194]; ureter morphogenesis [GO:0072197] axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DPSTFYPWLIHRYRYLGHR 1 11.2 0.97517 -1.4419 0 0 0 0 13.6188 12.9858 0 0 0 0 0 0 Q04759 KPCT_HUMAN Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) PRKCQ PRKCT Homo sapiens (Human) "axon guidance [GO:0007411]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell chemotaxis [GO:0060326]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell activation [GO:0050870]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 2 cell activation [GO:2000570]; positive regulation of telomere maintenance [GO:0032206]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of platelet aggregation [GO:0090330]" aggresome [GO:0016235]; centriolar satellite [GO:0034451]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" EINWEELER;ETMFHKERFK;IEDFILHK;KEIDPPFRPKVK;TNQFFAIKALKK;WLEKEAK 6 8.2 0.97623 -4.66 0 0 12.1701 0 11.6508 11.0269 0 0 0 10.3864 0 0 Q04760 LGUL_HUMAN Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) GLO1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lactoylglutathione lyase activity [GO:0004462]; zinc ion binding [GO:0008270] SLDFYTR;VLGMTLIQK 2 8.7 0.94121 -0.5899 0 11.0262 0 0 0 8.85891 0 0 0 0 0 0 Q04771 ACVR1_HUMAN Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) ACVR1 ACVRLK2 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac muscle cell fate commitment [GO:0060923]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endocardial cushion formation [GO:0003272]; endocardial cushion fusion [GO:0003274]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; osteoblast differentiation [GO:0001649]; pharyngeal system development [GO:0060037]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular septum morphogenesis [GO:0060412] activin receptor complex [GO:0048179]; apical part of cell [GO:0045177]; BMP receptor complex [GO:0070724]; plasma membrane [GO:0005886] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase binding [GO:1990782]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" TVARQITLLECVGK 1 2.8 0.92105 -0.44177 0 0 11.1989 0 0 0 0 0 0 0 0 0 Q04837 SSBP_HUMAN "Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)" SSBP1 SSBP Homo sapiens (Human) DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; positive regulation of helicase activity [GO:0051096]; positive regulation of mitochondrial DNA replication [GO:0090297]; protein homotetramerization [GO:0051289] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] DVAYQYVKK;MFRRPVLQVLRQFVR;QATTIIADNIIFLSDQTK;VGQDPVLR;VGQDPVLRQVEGK 5 37.2 0.98016 -1.5585 0 0 0 0 0 4.17848 12.0319 0 0 0 0 0 Q04844 ACHE_HUMAN Acetylcholine receptor subunit epsilon CHRNE ACHRE Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; membrane depolarization [GO:0051899]; muscle contraction [GO:0006936]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic cation transmembrane transporter activity [GO:0008324]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] MARAPLGVLLLLGLLGRGVGK 1 4.3 0.52581 0.18665 0 0 5.07857 0 5.01471 0 0 0 0 0 0 0 Q04864 REL_HUMAN Proto-oncogene c-Rel REL Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASGAYNPYIEIIEQPR;ASGAYNPYIEIIEQPRQRGMR;DGYYEAEFGQER 3 5.3 0.95522 -0.82944 0 11.0185 0 7.5614 0 6.63709 0 0 0 0 8.16998 0 Q04900 MUC24_HUMAN Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) (CD antigen CD164) CD164 Homo sapiens (Human) cell adhesion [GO:0007155]; hemopoiesis [GO:0030097]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; signal transduction [GO:0007165] endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] KSTFDAASFIGGIVLVLEIR 1 10.6 0.57765 0.18087 0 0 0 0 0 0 5.18805 0 0 0 0 0 Q04912 RON_HUMAN Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] MST1R PTK8 RON Homo sapiens (Human) cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; defense response [GO:0006952]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to virus [GO:0009615]; signal transduction [GO:0007165]; single fertilization [GO:0007338] cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]; vacuole [GO:0005773] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; enzyme binding [GO:0019899]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CERQLPEQQLCRLPEYVVR;DLAARNCMLDESFTVK;DVLIPHERVVTHSDR;EYYSVQQHRHAR;VADFGLARDILDREYYSVQQHR 5 5.4 0.98042 -1.6392 7.65957 0 12.0717 0 0 0 0 0 10.4128 9.67373 9.11267 0 Q04941 PLP2_HUMAN Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein) PLP2 A4 Homo sapiens (Human) chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; monoatomic ion transport [GO:0006811] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemokine binding [GO:0019956]; monoatomic ion transmembrane transporter activity [GO:0015075] HTAAPTDPADGPV;TLIAAILYLITSIVVLVER 2 21.1 0 16.663 0 0 0 0 0 0 0 9.6764 4.82975 11.9681 11.6807 0 Q05084 ICA69_HUMAN Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) ICA1 Homo sapiens (Human) neurotransmitter transport [GO:0006836]; regulation of transport [GO:0051049] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672] membrane curvature sensor activity [GO:0140090]; protein domain specific binding [GO:0019904] LALRNPLCR;LVEKEEKK;SVVNKMQQK;TEYRGALLWMK 4 7.7 0.97545 -3.3456 0 0 0 13.446 0 0 0 0 3.88733 10.8066 7.71555 13.4454 Q05086 UBE3A_HUMAN Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) UBE3A E6AP EPVE6AP HPVE6A Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; locomotory exploration behavior [GO:0035641]; motor learning [GO:0061743]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to cocaine [GO:0042220]; response to hydrogen peroxide [GO:0042542]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; proteasome complex [GO:0000502]; synaptic vesicle [GO:0008021] metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IPITNENRKEFVNLYSDYILNK;ITVLYSLVQGQQLNPYLRLKVR;LGPDDVSVDIDAIR 3 6.6 0.086687 0.38021 0 0 0 0 0 4.10199 0 0 0 8.70698 6.71754 0 Q05193 DYN1_HUMAN Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) DNM1 DNM Homo sapiens (Human) clathrin coat assembly involved in endocytosis [GO:0099049]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; modulation of chemical synaptic transmission [GO:0050804]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; vesicle scission [GO:0099050] cell projection [GO:0042995]; chromaffin granule [GO:0042583]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane coat [GO:0030117]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic endocytic zone membrane [GO:0098835]; synapse [GO:0045202] "GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]" ASFLRAGVYPER;GISPVPINLR;HLADRMGTPYLQK;IVTTHIR;TVRDLMPK;VTGTNKGISPVPINLR 6 6.5 0.97635 -4.7017 0 0 0 9.24434 3.38018 10.4541 9.66869 8.73112 12.3064 0 0 11.3216 Q05209 PTN12_HUMAN Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) PTPN12 Homo sapiens (Human) cellular response to epidermal growth factor stimulus [GO:0071364]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; tissue regeneration [GO:0042246] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]" SEWSELQSQERSEQK;TRSCLVEGDAK 2 3.3 0.94178 -0.61336 0 4.79447 12.7791 0 0 0 0 0 0 0 0 0 Q05315 LEG10_HUMAN Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase) CLC LGALS10 LGALS10A Homo sapiens (Human) regulation of activated T cell proliferation [GO:0046006]; regulation of T cell anergy [GO:0002667]; regulation of T cell cytokine production [GO:0002724]; T cell apoptotic process [GO:0070231] collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829] carbohydrate binding [GO:0030246]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802] DISLTKFNVSYLK 1 9.2 0.92179 -0.44209 0 0 0 0 0 0 0 0 12.0039 0 0 0 Q05329 DCE2_HUMAN Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) GAD2 GAD65 Homo sapiens (Human) cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyrate shunt [GO:0006540]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; response to caloric restriction [GO:0061771]; response to cocaine [GO:0042220]; response to dexamethasone [GO:0071548]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410] axon [GO:0030424]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; inhibitory synapse [GO:0060077]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] glutamate binding [GO:0016595]; glutamate decarboxylase activity [GO:0004351]; protein-containing complex binding [GO:0044877]; pyridoxal phosphate binding [GO:0030170] GAAALGIGTDSVILIKCDER 1 3.4 0.9437 -0.62842 0 0 0 0 0 0 0 11.1918 0 0 0 0 Q05397 FAK1_HUMAN Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) PTK2 FAK FAK1 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell motility [GO:0048870]; detection of muscle stretch [GO:0035995]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-cell adhesion [GO:0022408]; netrin-activated signaling pathway [GO:0038007]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell cortex [GO:0005938]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin binding [GO:0003779]; ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; integrin binding [GO:0005178]; JUN kinase binding [GO:0008432]; molecular function activator activity [GO:0140677]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169] ALPSIPK;DYEIQRER;NLLDVIDQAR 3 2.4 0.95816 -1.0129 0 0 0 10.2704 0 0 0 0 12.8623 0 3.34199 0 Q05469 LIPS_HUMAN Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) LIPE Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; protein phosphorylation [GO:0006468]; triglyceride catabolic process [GO:0019433] caveola [GO:0005901]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020] "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; diacylglycerol lipase activity [GO:0120516]; monoacylglycerol lipase activity [GO:0047372]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]" ALGMMGLVRR;GLGVRAAFPEGFHPR;ITQNLDVHFWK;LISYDLR;QGSLTELGFLTKLQELSIQR;SVSEAALAQPQGPLGTDSLK 6 7.7 0.95389 -0.89392 0 0 0 6.82324 10.5678 10.4439 0 0 0 10.5524 0 0 Q05481 ZNF91_HUMAN Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10) ZNF91 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; transposable element silencing [GO:0010526] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" CEECGKAFNRSSK;EKPYKCKECGK;HTRMHTGEKPYK;ITHTEEKPYKCK 4 7.8 0.97319 -2.6528 0 12.4717 0 0 0 0 0 0 0 0 6.59834 10.8131 Q05513 KPCZ_HUMAN Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) PRKCZ PKC2 Homo sapiens (Human) cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein transport [GO:0051222]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165]; vesicle transport along microtubule [GO:0047496] apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; axon hillock [GO:0043203]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myelin sheath abaxonal region [GO:0035748]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; PAR polarity complex [GO:0120157]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; stress fiber [GO:0001725]; tight junction [GO:0070160]; vesicle [GO:0031982] "14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]" GIIYRDLK;LGCRPQTGFSDIK;LGCRPQTGFSDIKSHAFFR;LPEEHARFYAAEICIALNFLHER 4 8.4 0.94615 -0.65198 0 0 0 0 9.30458 0 0 0 0 0 6.93676 9.24082 Q05516 ZBT16_HUMAN Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) ZBTB16 PLZF ZNF145 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification involved in bone maturation [GO:0043931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; type 2 angiotensin receptor binding [GO:0031703]" LGELAVGMK;TYGCELCGKRFLDSLR 2 3.7 0.88091 -0.16826 0 0 0 0 0 0 0 0 0 0 0 8.91349 Q05519 SRS11_HUMAN "Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)" SRSF11 SFRS11 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723] VNGDDHHEEDMDMSD 1 3.1 0.66095 0.16903 0 0 0 4.88132 0 0 0 0 0 6.39381 0 0 Q05586 NMDZ1_HUMAN "Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1)" GRIN1 NMDAR1 Homo sapiens (Human) "brain development [GO:0007420]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propylene metabolic process [GO:0018964]; protein heterotetramerization [GO:0051290]; regulation of membrane potential [GO:0042391]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; response to glycine [GO:1905429]; sodium ion transmembrane transport [GO:0035725]; visual learning [GO:0008542]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity [GO:0015276]; ligand-gated sodium channel activity [GO:0015280]; NMDA glutamate receptor activity [GO:0004972]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity [GO:0022824] GALQNQK;ITGINDPR 2 1.6 0.95283 -0.76109 0 0 0 0 0 0 0 0 0 0 11.3478 9.9382 Q05639 EF1A2_HUMAN Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) EEF1A2 EEF1AL STN Homo sapiens (Human) positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid kinase activity [GO:0090218]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; eukaryotic translation elongation factor 1 complex [GO:0005853]; synapse [GO:0045202] "GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]" EAAEMGK;EHALLAYTLGVK;EVSAYIK;IGGIGTVPVGR;KLEDNPKSLK;LKAERER;LPLQDVYK;QLIVGVNK;QTVAVGVIK;STTTGHLIYK;THINIVVIGHVDSGK;TIEKFEK 12 24 0.98072 -1.5531 0 0 11.0928 5.39029 0 0 0 0 0 12.0394 0 0 Q05655 KPCD_HUMAN Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] PRKCD PKCD Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cellular response to angiotensin [GO:1904385]; cellular response to fatty acid [GO:0071398]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; neutrophil activation [GO:0042119]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of phospholipid scramblase activity [GO:1900163]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of ceramide biosynthetic process [GO:2000303]; regulation of mRNA stability [GO:0043488]; signal transduction [GO:0007165]; termination of signal transduction [GO:0023021] azurophil granule lumen [GO:0035578]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" FELYRATFYAAEIMCGLQFLHSK;GIIYRDLK;KPTMYPEWK;LEPPFRPKVKSPR;QDNSGTYGK 5 8.8 0.97961 -1.546 0 0 0 0 5.50395 0 7.88399 7.35341 0 0 0 0 Q05682 CALD1_HUMAN Caldesmon (CDM) CALD1 CAD CDM Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; angiogenesis [GO:0001525]; muscle contraction [GO:0006936] actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin binding [GO:0003779]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; myosin binding [GO:0017022]; tropomyosin binding [GO:0005523] AEFLNKSVQKSSGVK;EEEEEEKPKR;EPKEEVKSFMDR;KLREEEEK;SQNGEFMTHKLK;TTTTNTQVEGDDEAAFLER;VLEEEEQR 7 10.6 0.85058 -0.075302 0 0 0 0 0 0 0 0 0 0 0 8.54106 Q05682 CALD1_HUMAN Caldesmon (CDM) CALD1 CAD CDM Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; angiogenesis [GO:0001525]; muscle contraction [GO:0006936] actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin binding [GO:0003779]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; myosin binding [GO:0017022]; tropomyosin binding [GO:0005523] EEEEEEKPKR;EPKEEVKSFMDR;KLREEEEK;SGVKSTHQAAIVSK;SQNGEFMTHKLK;TTTTNTQVEGDDEAAFLER;VLEEEEQR 7 14.7 0.97507 -3.2747 0 12.7789 0 0 0 8.95376 0 0 8.52125 9.35293 10.136 10.2372 Q05707 COEA1_HUMAN Collagen alpha-1(XIV) chain (Undulin) COL14A1 UND Homo sapiens (Human) cell-cell adhesion [GO:0098609]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; homeostasis of number of cells within a tissue [GO:0048873]; regulation of cell growth involved in cardiac muscle cell development [GO:0061050]; ventricular cardiac muscle tissue development [GO:0003229] collagen trimer [GO:0005581]; collagen type XIV trimer [GO:0005596]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] FNFRLVR;HCFYGLQPDSEYKISVYTK;LNAYKTK 3 1.8 0.97562 -3.3242 0 0 0 8.43125 0 0 0 0 0 0 0 0 Q05823 RN5A_HUMAN 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) RNASEL RNS4 Homo sapiens (Human) defense response to virus [GO:0051607]; fat cell differentiation [GO:0045444]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of D-glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843] GHVEVLK;INECVMK;INECVMKKMNK;NLGEHIDEEKHK;VLLSHGAK 5 5.1 0.97822 -2.1384 0 7.16993 7.08119 12.3282 0 0 0 9.8177 0 15.6312 15.6833 0 Q05932 FOLC_HUMAN "Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)" FPGS Homo sapiens (Human) animal organ regeneration [GO:0031100]; cell population proliferation [GO:0008283]; folic acid metabolic process [GO:0046655]; folic acid-containing compound metabolic process [GO:0006760]; glutamate metabolic process [GO:0006536]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; one-carbon metabolic process [GO:0006730]; tetrahydrofolylpolyglutamate biosynthetic process [GO:0046901] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326] DPAALLK;HGAGEPK;IAWQKGGIFK 3 4.1 0.95824 -1.0028 10.1597 0 4.50138 0 0 11.5032 0 0 0 0 0 0 Q05952 STP2_HUMAN Nuclear transition protein 2 (TP-2) (TP2) TNP2 Homo sapiens (Human) acrosome reaction [GO:0007340]; penetration of zona pellucida [GO:0007341]; positive regulation of protein processing [GO:0010954]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283] nucleolus [GO:0005730]; nucleosome [GO:0000786] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] KTMNSHHSPMRPTILHCR 1 13 0.60319 0.17782 0 0 0 6.53835 0 0 0 0 0 0 0 0 Q05996 ZP2_HUMAN Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2] ZP2 ZPA Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468] collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886] acrosin binding [GO:0032190]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804] ATGATEAEK 1 1.2 0.9179 -0.40781 0 0 0 0 0 0 0 0 0 0 8.38896 0 Q05BU3 F86JP_HUMAN Putative protein FAM86JP FAM86JP Homo sapiens (Human) MPGAFSQNSSK 1 27.5 0.89799 -0.23388 0 0 0 0 0 0 0 0 0 0 0 8.44584 Q05BV3 EMAL5_HUMAN Echinoderm microtubule-associated protein-like 5 (EMAP-5) EML5 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] microtubule binding [GO:0008017] DYVATGQVGR;EDLPQLKEQCKEK;EGGAVKLWDQELR;EVTSTEEIK;LETGQATDCVR;LLQVNTGAKEQLFFEAPR;NAEIIEVGEK;TVCYSPEGDMVAIGMK;VLVATGQVGK;YLQTNDGNGKRLFYR 10 6.3 0.97628 -4.6523 0 11.8501 12.1106 5.97975 9.07478 10.8754 11.523 11.4094 10.7283 0 0 0 Q05C16 LRC63_HUMAN Leucine-rich repeat-containing protein 63 LRRC63 Homo sapiens (Human) intracellular signal transduction [GO:0035556] FYDKIPVEVQK;QKPPLLLRRPLPPK;QKPPLLLRRPLPPKFTK;VTAISSPQK 4 6.3 0.97628 -2.2916 5.86844 8.30574 6.34811 0 4.21638 0 0 7.88618 0 0 0 0 Q05D32 CTSL2_HUMAN CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) CTDSPL2 HSPC058 HSPC129 Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611] nucleoplasm [GO:0005654] phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] AGEKPNK 1 1.5 0.90898 -0.31304 0 0 0 0 0 0 0 0 0 0 9.27317 0 Q05D60 DEUP1_HUMAN Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) DEUP1 CCDC67 Homo sapiens (Human) cell projection organization [GO:0030030]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; multi-ciliated epithelial cell differentiation [GO:1903251] centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536] identical protein binding [GO:0042802] LKSAVNEIALSRNK;LQYENER;LSHDCEPNR;SELQSRDDLLR;SQLQQVEEYHNSEQER 5 9.4 0.95233 -0.73785 0 0 0 0 0 7.59574 0 0 0 9.71268 0 4.00988 Q05DH4 FHI1A_HUMAN FHF complex subunit HOOK-interacting protein 1A (FHIP1A) (FTS- and Hook-interacting protein like) (FHIP-L) FHIP1A FAM160A1 Homo sapiens (Human) protein localization to perinuclear region of cytoplasm [GO:1905719] DPIQEASRTGSGK;LEEKGEEWHCLLK;LFLWSLRREFTDETK;SLYQVLASVK 4 4.9 0.98014 -1.6007 0 0 0 0 0 0 0 0 11.1013 9.03947 9.98897 7.50359 Q06033 ITIH3_HUMAN Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH3 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] AREEHRIPER;AVPSTFSWLDTVTVTQDGLSMMINR;GISMLNK;VALSHLGSALQLGSLCFPR 4 6.9 0.91051 -0.28879 0 0 0 0 0 0 11.5952 0 0 7.99396 0 10.5159 Q06124 PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) PTPN11 PTP2C SHPTP2 Homo sapiens (Human) atrioventricular canal development [GO:0036302]; axonogenesis [GO:0007409]; Bergmann glial cell differentiation [GO:0060020]; brain development [GO:0007420]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellar cortex formation [GO:0021697]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage checkpoint signaling [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; homeostasis of number of cells within a tissue [GO:0048873]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; intestinal epithelial cell migration [GO:0061582]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organism growth [GO:0035264]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of type I interferon production [GO:0032480]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of D-glucose import [GO:0046326]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hormone secretion [GO:0046887]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of protein export from nucleus [GO:0046825]; regulation of protein-containing complex assembly [GO:0043254]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; insulin receptor binding [GO:0005158]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; peptide hormone receptor binding [GO:0051428]; phosphoprotein phosphatase activity [GO:0004721]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor complex adaptor activity [GO:0030159]" RNGAVTHIK;VGQGNTERTVWQYHFR;VIVMTTK 3 5.4 0.97891 -1.965 0 0 0 0 0 0 0 0 0 0 0 9.59774 Q06187 BTK_HUMAN Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) BTK AGMX1 ATK BPK Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; B cell affinity maturation [GO:0002344]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell maturation [GO:0048469]; cellular response to interleukin-7 [GO:0098761]; cellular response to molecule of fungal origin [GO:0071226]; cellular response to reactive oxygen species [GO:0034614]; eosinophil homeostasis [GO:1990959]; Fc-epsilon receptor signaling pathway [GO:0038095]; histamine secretion by mast cell [GO:0002553]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; monocyte proliferation [GO:0061516]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; neutrophil homeostasis [GO:0001780]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17A production [GO:0150153]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of phagocytosis [GO:0050766]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I hypersensitivity [GO:0001812]; positive regulation of type III hypersensitivity [GO:0001805]; protein phosphorylation [GO:0006468]; proteoglycan catabolic process [GO:0030167]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell cytokine production [GO:0002721]; response to lipopolysaccharide [GO:0032496]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]" DSSKAGK;ITCVETVVPEK;NGSLKPGSSHR;WSPPEVLMYSKFSSK 4 6.7 0.97653 -2.1776 0 0 0 0 0 0 11.6466 0 0 7.76188 10.0333 9.70662 Q06190 P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; somitogenesis [GO:0001756] protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674] AAGGEKTGFVTAQSFIAMWR;DIAGEAISFASGK;IKEFSFEK;ILSASLPEK;VSSPIEK 5 5 0.97218 -2.6955 0 0 0 0 0 10.3688 11.0384 0 12.8831 0 0 8.67712 Q06190 P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; somitogenesis [GO:0001756] protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674] AAGGEKTGFVTAQSFIAMWR;DPDLRGELAFLAR;ILSASLPEK 3 7.9 0.98062 -1.6202 0 0 0 0 0 0 0 10.4308 0 0 0 0 Q06210 GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) GFPT1 GFAT GFPT Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829]; extracellular exosome [GO:0070062] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] GSPLLIGVR;ISMQERR;SVHFPGQAVGTRR 3 4.1 0.91237 -0.32256 0 0 0 0 0 9.6539 0 0 0 0 0 0 Q06265 EXOS9_HUMAN Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) EXOSC9 PMSCL1 Homo sapiens (Human) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; immune response [GO:0006955]; mRNA catabolic process [GO:0006402]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] IAGVKVAEITELILK;LDGRQTYDYRNIR 2 6.4 0.87324 -0.11189 6.07946 0 0 0 10.0653 0 0 0 0 0 0 0 Q06278 AOXA_HUMAN Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-) AOX1 AO Homo sapiens (Human) lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; extracellular exosome [GO:0070062] "2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]" TLIISFLFK;TLIISFLFKFYLEVSQILK;YPQAPVIMGNTSVGPEVK 3 2.8 0.95392 -0.91778 0 0 8.03612 0 0 0 0 0 0 8.72038 0 0 Q06323 PSME1_HUMAN Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) PSME1 IFI5111 Homo sapiens (Human) antigen processing and presentation of exogenous antigen [GO:0019884]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] endopeptidase activator activity [GO:0061133] APLDIPVPDPVKEK;MAMLRVQPEAQAK;QGQGRGGQR;VQPEAQAK 4 14.4 0.97581 -2.3457 0 0 0 0 7.86654 0 0 0 0 8.51365 0 0 Q06413 MEF2C_HUMAN Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) MEF2C Homo sapiens (Human) "AMPA selective glutamate receptor signaling pathway [GO:0098990]; apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of dendritic spine development [GO:0060998]; regulation of DNA-templated transcription [GO:0006355]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GLNGCDSPDPDADDSVGHSPESEDKYR;LSEGWAT 2 7.2 0.84095 -0.045996 0 0 0 0 0 0 0 0 6.27318 0 0 0 Q06413 MEF2C_HUMAN Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) MEF2C Homo sapiens (Human) "AMPA selective glutamate receptor signaling pathway [GO:0098990]; apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of dendritic spine development [GO:0060998]; regulation of DNA-templated transcription [GO:0006355]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" LSEGWAT;TNSDIVEALNKKENK 2 4.8 0.92862 -0.46245 0 0 0 6.36485 6.5428 0 0 0 0 0 0 0 Q06416 P5F1B_HUMAN "Putative POU domain, class 5, transcription factor 1B (Oct4-pg1) (Octamer-binding protein 3-like) (Octamer-binding transcription factor 3-like)" POU5F1B OCT4PG1 OTF3C OTF3P1 POU5F1P1 POU5FLC20 POU5FLC8 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VFSQKTICRFEALQLSFK 1 5 0.85906 -0.082441 0 0 0 0 0 0 0 0 0 0 7.43912 0 Q06418 TYRO3_HUMAN Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) TYRO3 BYK DTK RSE SKY TIF Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; natural killer cell differentiation [GO:0001779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; neuropeptide signaling pathway [GO:0007218]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of viral life cycle [GO:1903902]; protein autophosphorylation [GO:0046777]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; vagina development [GO:0060068] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] GEPAVHFRAAR;LMGAPVK;TSWVPVVLGVLTALVTAAALALILLR;TSWVPVVLGVLTALVTAAALALILLRK 4 5.1 0.90314 -0.26556 0 9.82933 0 0 9.77474 0 0 9.27815 0 4.17959 9.96464 0 Q06455 MTG8_HUMAN Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599] nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AEEAVNEVK;QAMTELQKAVSEAER 2 4 0.95193 -0.71265 10.5148 0 0 0 0 0 0 0 11.5083 0 0 0 Q06481 APLP2_HUMAN Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) APLP2 APPL2 Homo sapiens (Human) axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; G protein-coupled receptor signaling pathway [GO:0007186] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] DNA binding [GO:0003677]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type endopeptidase inhibitor activity [GO:0004867]; transition metal ion binding [GO:0046914] AVCSQEAMTGPCR;EEEEEDEEEEEEEDEEEDYDVYK;VEAMLNDRR 3 5.9 0.87388 -0.11052 0 0 12.1631 0 0 0 4.58448 0 0 0 5.46858 0 Q06495 NPT2A_HUMAN Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) SLC34A1 NPT2 SLC17A2 Homo sapiens (Human) arsenate ion transmembrane transport [GO:1901684]; cellular response to metal ion [GO:0071248]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phosphate starvation [GO:0016036]; cellular response to staurosporine [GO:0072734]; dentinogenesis [GO:0097187]; gentamycin metabolic process [GO:1901128]; glycoprotein metabolic process [GO:0009100]; indole metabolic process [GO:0042431]; intracellular phosphate ion homeostasis [GO:0030643]; kidney development [GO:0001822]; ossification [GO:0001503]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; positive regulation of membrane potential [GO:0045838]; positive regulation of phosphate transmembrane transport [GO:2000187]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to lead ion [GO:0010288]; response to magnesium ion [GO:0032026]; response to mercury ion [GO:0046689]; response to peptide [GO:1901652]; response to potassium ion [GO:0035864]; response to thyroid hormone [GO:0097066]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; sodium ion import across plasma membrane [GO:0098719]; sodium-dependent phosphate transport [GO:0044341]; tricarboxylic acid metabolic process [GO:0072350] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; sodium:phosphate symporter activity [GO:0005436] SPGHLPK;SPPLPPR 2 2.2 0.94559 -0.64274 0 0 3.98541 8.20721 0 0 0 0 0 9.86051 0 0 Q06520 ST2A1_HUMAN Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3) SULT2A1 HST STD Homo sapiens (Human) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; cholesterol metabolic process [GO:0008203]; ethanol catabolic process [GO:0006068]; lipid catabolic process [GO:0016042]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; bile-salt sulfotransferase activity [GO:0047704]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] LFQEKMADLPRELFPWE;NMKFIKKPK 2 9.1 0.96715 -1.3149 0 0 0 0 0 0 0 0 0 0 7.58601 10.0913 Q06546 GABPA_HUMAN GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) GABPA E4TF1A Homo sapiens (Human) blastocyst formation [GO:0001825]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" EFSMTDIDLTTLNISGR;VINSSAKAAKVQR 2 6.6 0.74882 0.08441 0 0 0 0 0 0 0 0 0 8.55758 0 9.22135 Q06547 GABP1_HUMAN GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53) GABPB1 E4TF1B GABPB GABPB2 Homo sapiens (Human) mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription cis-regulatory region binding [GO:0000976] QLDEANR 1 1.8 0.92896 -0.46187 0 0 0 0 0 0 0 0 0 0 0 9.10599 Q06730 ZN33A_HUMAN Zinc finger protein 33A (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK) (Zinc finger protein 11A) (Zinc finger protein KOX31) ZNF33A KIAA0065 KOX31 ZNF11 ZNF11A ZNF33 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ENAEENNCDYNEFGR;ERSQENQSK;TFCQKSDLTK 3 4.2 0.97231 -2.7637 0 0 0 0 0 0 0 10.7243 0 0 6.4706 0 Q06732 ZN33B_HUMAN Zinc finger protein 33B (Zinc finger protein 11B) (Zinc finger protein KOX2) ZNF33B KOX2 ZNF11B Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVFNTRK;ENAEENNCDYNEFGR;ERSQENQSK 3 4 0.7832 0.025746 0 0 10.2158 0 0 0 0 0 0 0 0 0 Q06787 FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) FMR1 Homo sapiens (Human) "animal organ development [GO:0048513]; cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]" "axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]" chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325] GNDDHSR;QIGASSRPPPNRTDK 2 3.5 0.96508 -1.2295 0 11.2517 0 0 0 0 0 0 0 7.38267 0 0 Q06787 FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) FMR1 Homo sapiens (Human) "animal organ development [GO:0048513]; cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]" "axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]" chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325] IPPVKVVGCAR 1 2.1 0.88849 -0.18765 0 0 0 0 0 0 5.41849 0 0 0 0 0 Q06828 FMOD_HUMAN Fibromodulin (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin) FMOD FM SLRR2E Homo sapiens (Human) collagen fibril organization [GO:0030199]; transforming growth factor beta receptor complex assembly [GO:0007181] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] KVFSKLR;YLPFVPSRMK 2 4.5 0.9744 -1.3934 0 0 0 0 0 0 0 0 0 4.59932 0 0 Q06830 PRDX1_HUMAN Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) PRDX1 PAGA PAGB TDPX2 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; erythrocyte homeostasis [GO:0034101]; fibroblast proliferation [GO:0048144]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of stress-activated MAPK cascade [GO:0032872]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; RNA binding [GO:0003723]; thioredoxin peroxidase activity [GO:0008379] ADEGISFR;ATAVMPDGQFK;DISLSDYK;DISLSDYKGK;GLFIIDDKGILR;IGHPAPNFK;KQGGLGPMNIPLVSDPK;LVQAFQFTDK;QGGLGPMNIPLVSDPK;QGGLGPMNIPLVSDPKR;QITVNDLPVGR;SVDETLR;TIAQDYGVLK 13 53.3 0 62.977 13.8017 13.6744 13.5752 12.358 8.32247 8.00607 15.1521 15.4684 15.3122 13.721 14.2421 14.7707 Q07020 RL18_HUMAN Large ribosomal subunit protein eL18 (60S ribosomal protein L18) RPL18 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ILTFDQLALDSPK;KMKLPGR;TAVVVGTITDDVR;TNSTFNQVVLK;TNSTFNQVVLKRLFMSR 5 26.6 0 48.242 13.2815 13.5139 12.9759 10.7307 10.4333 10.4653 12.416 12.5419 13.3742 6.73091 12.2448 12.4494 Q07021 C1QBP_HUMAN "Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)" C1QBP GC1QBP HABP1 SF2P32 Homo sapiens (Human) "apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; cytosolic ribosome assembly [GO:0042256]; DNA damage response [GO:0006974]; immune response [GO:0006955]; innate immune response [GO:0045087]; mitochondrial RNA catabolic process [GO:0000957]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adrenergic receptor binding [GO:0031690]; C5-methylcytidine-containing RNA reader activity [GO:0062153]; complement component C1q complex binding [GO:0001849]; deoxyribonuclease inhibitor activity [GO:0060703]; enzyme inhibitor activity [GO:0004857]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] GPCACGCGCGSLHTDGDK;IQKHKTLPK;VLGSSVAGLR 3 13.1 0.98063 -1.6212 0 0 0 0 6.74389 0 0 0 0 0 0 0 Q07065 CKAP4_HUMAN Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) CKAP4 Homo sapiens (Human) azurophil granule membrane [GO:0035577]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; specific granule membrane [GO:0035579] RNA binding [GO:0003723] ELVSLKQEQQAFK;LLRSEESVSR;QGESEVSR 3 5.1 0.97597 -2.3295 0 0 3.07274 0 0 3.73368 0 11.5538 0 7.90111 0 0 Q07075 AMPE_HUMAN Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249) ENPEP Homo sapiens (Human) angiogenesis [GO:0001525]; angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; glomerulus development [GO:0032835]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] ATYTISITHPK;ESASSNQQR;ITRLPELK;SIVATDHEPTDAR 4 4.3 0.95555 -0.86832 0 0 7.90863 0 0 0 10.6244 10.2947 0 10.6899 0 0 Q07092 COGA1_HUMAN Collagen alpha-1(XVI) chain COL16A1 FP1572 Homo sapiens (Human) cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amino acid stimulus [GO:0071230]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894] collagen type IX trimer [GO:0005594]; collagen type XVI trimer [GO:0005597]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178] GAKVHQETAADECPPCVHGAR;VGSPGPPGPQAEKGSEGIR 2 2.5 0.97446 -1.3801 12.8964 0 0 0 0 0 0 0 0 0 0 0 Q07157 ZO1_HUMAN Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; adherens junction maintenance [GO:0034334]; ameloblast differentiation [GO:0036305]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of apoptotic process [GO:0043066]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to adherens junction [GO:0071896]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell-cell junction [GO:0150105]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell junction assembly [GO:1901888]; regulation of cytoskeleton organization [GO:0051493] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; podosome [GO:0002102]; protein-containing complex [GO:0032991]; tight junction [GO:0070160] cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cell adhesion molecule binding [GO:0050839] GKPPEADGVDRSFGEK;IDSPGFKPASQQVYR;LGSWLAIRIGKNHK;QHPEESSER;SARAAAAK;SEKIWPR;SFPDKAPVNGTEQTQKTVTPAYNR;SLSPRSDRR;SNHYDPEEDEEYYR;TVEEVTVER;TVTPAYNR 11 7.5 0.97805 -7.0617 10.6149 0 12.7842 3.83703 8.94682 10.2973 0 9.94136 0 0 10.1552 8.05859 Q07283 TRHY_HUMAN Trichohyalin TCHH THH THL TRHY Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] EEETERHEQER;EQQLLQEEEEELQREER;EREKELQFLEEEEQLQR;FLPEEEEKEQRR;GREEKQQQR;KFLEEEQRLR;LEEQKVR;NLLEREFGAVLRRPHDPK;QEREQQLR;QLEDSQLRDR;QQKEEQRHR;QVGEIKSQEGK;REEETERHEQER;VYSRPRKQEGQR;WQWEPEKENAVR 15 8.9 0.97825 -6.4633 0 9.18254 9.36087 10.5795 9.21427 0 11.2311 9.75387 12.3284 10.8883 3.28079 11.9115 Q07325 CXCL9_HUMAN C-X-C motif chemokine 9 (Gamma-interferon-induced monokine) (Monokine induced by interferon-gamma) (HuMIG) (MIG) (Small-inducible cytokine B9) CXCL9 CMK MIG SCYB9 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response [GO:0006952]; defense response to virus [GO:0051607]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; cytokine activity [GO:0005125] MKKSGVLFLLGIILLVLIGVQGTPVVR;NGVQTCLNPDSADVKELIKK 2 37.6 0.95443 -0.89861 0 0 0 0 0 0 7.08108 11.6863 0 0 0 0 Q07343 PDE4B_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)" PDE4B DPDE4 Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; leukocyte migration [GO:0050900]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of type II interferon production [GO:0032729]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell contraction [GO:0086004]; T cell receptor signaling pathway [GO:0050852] centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; gamma-tubulin complex [GO:0000930]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calcium channel regulator activity [GO:0005246]; cAMP binding [GO:0030552]; gamma-tubulin binding [GO:0043015]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]" SLELYRQWTDRIMEEFFQQGDK;VNPQEESYQK;VTSSGVLLLDNYTDR 3 6.4 0.98063 -1.7254 10.5211 0 0 0 0 0 12.779 0 0 0 0 0 Q07352 TISB_HUMAN "mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1)" ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; regulation of B cell differentiation [GO:0045577]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; regulation of translation [GO:0006417]; response to wounding [GO:0009611]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] 14-3-3 protein binding [GO:0071889]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] FHQNQLLSSLK;QPGGGQVNSSR 2 6.5 0.95316 -0.7627 0 0 0 0 0 0 0 0 0 0 13.6693 0 Q07444 NKG2E_HUMAN NKG2-E type II integral membrane protein (NK cell receptor E) (NKG2-E-activating NK receptor) KLRC3 NKG2E Homo sapiens (Human) cellular defense response [GO:0006968]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] IIVSISFRIKALELAVHQIK 1 7.8 0.85132 -0.079704 0 0 0 0 0 0 5.42915 0 0 0 0 0 Q07617 SPAG1_HUMAN Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) SPAG1 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]; single fertilization [GO:0007338] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; protein folding chaperone complex [GO:0101031] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] DFLATREK;EEDKMHFHETETFPAMK;FTSQFRSSFS;IDTAGLTEKEK;TLSEVER;VLDVEPDNDLAKK;VLELEPGNVK 7 18.3 0.97685 -4.7815 0 0 9.60607 0 0 0 11.062 0 0 0 6.45914 9.22277 Q07666 KHDR1_HUMAN "KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)" KHDRBS1 SAM68 Homo sapiens (Human) "G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of translational initiation [GO:0045948]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of RNA export from nucleus [GO:0046831]; regulation of RNA splicing [GO:0043484]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Grb2-Sos complex [GO:0070618]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] GALVRGTPVR;GGGGGSR;GTPVRGAITR;ILGPQGNTIK;LQEETGAK 5 9 0.92906 -0.46143 12.0913 0 11.5779 0 0 0 7.5509 0 0 11.0851 9.60929 9.65166 Q07699 SCN1B_HUMAN Sodium channel regulatory subunit beta-1 SCN1B Homo sapiens (Human) axon guidance [GO:0007411]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; corticospinal neuron axon guidance [GO:0021966]; locomotion [GO:0040011]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725] extracellular region [GO:0005576]; intercalated disc [GO:0014704]; node of Ranvier [GO:0033268]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518] sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] ILCISCK;LLFFENYEHNTSVVK 2 10.1 0.95551 -0.8763 0 8.45812 0 0 0 0 0 0 0 0 0 0 Q07812 BAX_HUMAN Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) BAX BCL2L4 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in mammary gland involution [GO:0060057]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; motor neuron apoptotic process [GO:0097049]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of reproductive process [GO:2000243]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein insertion into mitochondrial membrane [GO:0051204]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; supramolecular fiber organization [GO:0097435]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] BAK complex [GO:0097145]; BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pore complex [GO:0046930] BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] ERLLGWIQDQGGWVR;LLGWIQDQGGWVR;VAADMFSDGNFNWGR 3 13.8 0.89638 -0.24818 0 0 0 0 0 0 0 0 0 7.01826 0 8.94679 Q07812 BAX_HUMAN Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) BAX BCL2L4 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in mammary gland involution [GO:0060057]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; motor neuron apoptotic process [GO:0097049]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of reproductive process [GO:2000243]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein insertion into mitochondrial membrane [GO:0051204]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; supramolecular fiber organization [GO:0097435]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] BAK complex [GO:0097145]; BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pore complex [GO:0046930] BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] VAADMFSDGNFNWGR;VVALFYFASKLVLKAGVK 2 20.1 0.53991 0.18486 0 0 0 9.68331 9.28644 0 0 0 12.0374 0 12.1732 0 Q07820 MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) MCL1 BCL2L3 Homo sapiens (Human) cell fate determination [GO:0001709]; cellular homeostasis [GO:0019725]; DNA damage response [GO:0006974]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fusion [GO:0008053]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; regulation of apoptotic process [GO:0042981]; release of cytochrome c from mitochondria [GO:0001836]; response to cytokine [GO:0034097] Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; protein heterodimerization activity [GO:0046982]; protein transmembrane transporter activity [GO:0008320] DTKPMGRSGATSR 1 3.7 0.98188 -1.5811 0 0 0 0 0 0 0 0 0 9.6886 0 0 Q07837 SLC31_HUMAN "Amino acid transporter heavy chain SLC3A1 (D2h) (Neutral and basic amino acid transport protein) (NBAT) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transporter-related heavy chain) (rBAT)" SLC3A1 NBAT Homo sapiens (Human) amino acid transport [GO:0006865]; aspartate transmembrane transport [GO:0015810]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; gene expression [GO:0010467]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-cystine transmembrane transporter activity [GO:0015184]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877] EILFWLTVASVLVLIAATIAIIALSPK;NPDVQEEIK;QTAFRDR;TVWITSFYK;TVWITSFYKSSLK 5 8.2 0.97303 -2.58 8.75382 0 0 0 0 0 0 0 10.3386 0 0 12.3525 Q07864 DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) POLE POLE1 Homo sapiens (Human) "base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; embryonic organ development [GO:0048568]; G1/S transition of mitotic cell cycle [GO:0000082]; leading strand elongation [GO:0006272]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair, DNA gap filling [GO:0006297]" epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; zinc ion binding [GO:0008270]" IILCTKKR;LADYCRK;LSFHTVEDLVK;SLAQFSYLEPGSIR 4 1.7 0.96506 -1.1514 0 0 0 10.1184 10.0279 0 0 0 8.71757 0 12.9278 0 Q07866 KLC1_HUMAN Kinesin light chain 1 (KLC 1) KLC1 KLC KNS2 Homo sapiens (Human) cell adhesion [GO:0007155]; microtubule-based movement [GO:0007018]; stress granule disassembly [GO:0035617] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874] cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894] AQVRRLCQENQWLR;EAEPLCK;QALEDLEK;VAEVLNDPENMEK;YESGPDGGEEMK;YEVAVPLCK 6 10.8 0.97265 -1.3676 0 0 13.9817 0 0 0 8.6756 12.9927 13.0401 8.13036 4.6638 0 Q07869 PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) PPARA NR1C1 PPAR Homo sapiens (Human) behavioral response to nicotine [GO:0035095]; cell differentiation [GO:0030154]; cellular response to fructose stimulus [GO:0071332]; cellular response to starvation [GO:0009267]; circadian regulation of gene expression [GO:0032922]; enamel mineralization [GO:0070166]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; hormone-mediated signaling pathway [GO:0009755]; lipoprotein metabolic process [GO:0042157]; negative regulation of appetite [GO:0032099]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of glycolytic process [GO:0045820]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nitric oxide metabolic process [GO:0046209]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transformation of host cell by virus [GO:1904189]; regulation of circadian rhythm [GO:0042752]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid transport [GO:2000191]; regulation of ketone metabolic process [GO:0010565]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; wound healing [GO:0042060] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; lipid binding [GO:0008289]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; NFAT protein binding [GO:0051525]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; phosphatase binding [GO:0019902]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]" CQYCRFHK;LVANGIQNK 2 3.6 0.98034 -1.8701 0 0 0 0 10.6325 0 0 0 0 0 0 0 Q07889 SOS1_HUMAN Son of sevenless homolog 1 (SOS-1) SOS1 Homo sapiens (Human) axon guidance [GO:0007411]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cardiac atrium morphogenesis [GO:0003209]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; eyelid development in camera-type eye [GO:0061029]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle development [GO:0001942]; heart trabecula morphogenesis [GO:0061384]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; leukocyte migration [GO:0050900]; midbrain morphogenesis [GO:1904693]; multicellular organism growth [GO:0035264]; myelination [GO:0042552]; neurotrophin TRK receptor signaling pathway [GO:0048011]; pericardium morphogenesis [GO:0003344]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vitellogenesis [GO:0007296] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; GTPase complex [GO:1905360]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular condensate scaffold activity [GO:0140693]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] EEQMRLPSADVYR;ILEEAHELSEDHYKK;LVGNYVRNIR;NPKPLPRFPK;NPLSLPVEKIHPLLKEVLGYK;QSTSQHIPKLPPK 6 6.2 0.97442 -3.8252 0 0 0 13.1818 9.37104 6.25895 0 0 0 14.2975 14.4973 0 Q07890 SOS2_HUMAN Son of sevenless homolog 2 (SOS-2) SOS2 Homo sapiens (Human) B cell homeostasis [GO:0001782]; insulin receptor signaling pathway [GO:0008286]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982] GEQPISADLK;HGSTSGTLR;HIFLFDGLMISCKPNHGQTRLPGYSSAEYR;QLTLLESDLYRKVQPSELVGSVWTK;TEEGNNDFLK 5 6.3 0.97656 -2.2728 0 0 0 0 9.75203 0 0 9.66429 0 3.82467 10.0518 10.3482 Q07912 ACK1_HUMAN Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase-mediated signal transduction [GO:0007264] adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; epidermal growth factor receptor binding [GO:0005154]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase inhibitor activity [GO:0005095]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699] AGPCILPIVR;GERSAYQR;HQGHFLLGTLSR;LPQRGCPGDGPEAGRPADK 4 4.7 0.97487 -1.4357 0 0 0 10.5707 6.9735 0 11.5149 0 0 0 0 10.5633 Q07954 LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] LRP1 A2MR APR Homo sapiens (Human) amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta clearance by transcytosis [GO:0150093]; aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; astrocyte activation involved in immune response [GO:0002265]; cellular response to amyloid-beta [GO:1904646]; enzyme-linked receptor protein signaling pathway [GO:0007167]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; lysosomal transport [GO:0007041]; negative regulation of gene expression [GO:0010629]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; phagocytosis [GO:0006909]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipid transport [GO:0032370]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcytosis [GO:1904300]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of phospholipase A2 activity [GO:0032429]; retinoid metabolic process [GO:0001523]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endocytic vesicle membrane [GO:0030666]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235] alpha-2 macroglobulin receptor activity [GO:0016964]; amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; apolipoprotein receptor activity [GO:0030226]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; clathrin heavy chain binding [GO:0032050]; heparan sulfate proteoglycan binding [GO:0043395]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023] AAYCACR;CDADADCMDGSDEEACGTGVR;CDGDHDCADGSDEK;CDGDHDCADGSDEKDCTPR;CDGDTDCMDSSDEK;CDTEDDCGDHSDEPPDCPEFK;CNQFVDCEDASDEMNCSATDCSSYFR;DCADGADESIAAGCLYNSTCDDR;EFMCQNRQCIPK;ETGSGGWPNGLTVDYLEK;GVLFQPCER;IDGTERETILK;ITIVENVGSVEGLAYHR;LSGCSQDCEDLK;LYFSDATLDKIER;LYWADAK;NLNAPVQPFEDPEHMKNVIALAFDYR;QCSGYCENFGTCQMAADGSRQCR;QWECDGENDCHDQSDEAPK;TISVARLEKAAQTR;WKCDGEDDCGDGSDEPKEECDER;WRCDGDTDCMDSSDEK 22 7.4 0.97312 -2.8507 0 11.5924 0 6.88411 11.2651 0 7.1419 9.57715 9.79331 5.03532 5.92315 6.362 Q07955 SRSF1_HUMAN "Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)" SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; liver regeneration [GO:0097421]; mRNA 5'-splice site recognition [GO:0000395]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; oligodendrocyte differentiation [GO:0048709]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA topoisomerase binding [GO:0044547]; mRNA binding [GO:0003729]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723] DGTGVVEFVR;DGYDYDGYR;IYVGNLPPDIR 3 12.1 0 3.4297 0 0 7.00394 0 10.2551 0 12.5976 12.1764 11.4336 11.4017 11.5614 10.9994 Q07960 RHG01_HUMAN Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) ARHGAP1 CDC42GAP RHOGAP1 Homo sapiens (Human) endosomal transport [GO:0016197]; negative regulation of endocytic recycling [GO:2001136]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264]; transferrin transport [GO:0033572] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] DAYREFDR;HQIVEVAGDDK;SANTQVVR 3 6.2 0.98033 -1.8027 0 0 0 0 0 10.0941 0 0 0 0 0 0 Q07973 CP24A_HUMAN "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" CYP24A1 CYP24 Homo sapiens (Human) osteoblast differentiation [GO:0001649]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin D receptor signaling pathway [GO:0070561]; vitamin metabolic process [GO:0006766] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity [GO:0030342]; 25-hydroxycholecalciferol-23-hydroxylase activity [GO:0062180]; 25-hydroxycholecalciferol-24-hydroxylase activity [GO:0008403]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; vitamin D 25-hydroxylase activity [GO:0070643]" EGEDWQR;MYSCFSHREGEDWQR 2 4 0.91513 -0.33461 0 3.63238 0 5.30155 0 0 0 0 0 0 0 0 Q08043 ACTN3_HUMAN Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) ACTN3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; bone morphogenesis [GO:0060349]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of glycolytic process [GO:0045820]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of relaxation of muscle [GO:1901078]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of glucose catabolic process to lactate via pyruvate [GO:1904025]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue growth [GO:0048633]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of the force of skeletal muscle contraction [GO:0014728]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle atrophy [GO:0014732]; transition between fast and slow fiber [GO:0014883] actin filament [GO:0005884]; brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; structural constituent of muscle [GO:0008307]; transmembrane transporter binding [GO:0044325] ALDFIASK;DLLLDPAWEK;ELPAKQAEYCIRR;FAIQDISVEETSAK;ICKVLAVNQENEK;ILAGDKNYITPEELRR;TFTAWCNSHLRK;TINEVENQVLTR 8 10.9 0.97441 -3.6426 0 0 0 0 0 8.71795 0 11.9875 0 0 4.92044 12.629 Q08050 FOXM1_HUMAN Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) FOXM1 FKHL16 HFH11 MPP2 WIN Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of Ras protein signal transduction [GO:0046578]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SPTRCVSEMLVIQHRER;TELPLGARRK 2 3.5 0.95429 -0.95413 0 0 0 0 0 0 0 8.9646 0 8.94641 0 0 Q08116 RGS1_HUMAN Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20) RGS1 1R20 BL34 IER1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukotriene signaling pathway [GO:0061737]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; response to bacterium [GO:0009617]; signal transduction [GO:0007165] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] MQKRRPK 1 3.3 0.81617 -0.016752 0 0 0 0 0 0 13.163 0 0 0 0 0 Q08117 TLE5_HUMAN "TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)" TLE5 AES GRG GRG5 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of anoikis [GO:2000210]; regulation of growth [GO:0040008]; response to interleukin-1 [GO:0070555]; skeletal system development [GO:0001501]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] AAGSLFFDR;NGHDGDTHQEDDGEKSD 2 9.8 0.93786 -0.56949 0 0 0 0 0 0 3.52331 0 9.76258 3.35966 0 0 Q08170 SRSF4_HUMAN "Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)" SRSF4 SFRS4 SRP75 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to insulin [GO:0032868]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] AGSSKKK;DGSYGSGR;GSKRDSK;LIVENLSSR;SQEKSLRQSR;VIVEHAR 6 9.7 0.97442 -2.4454 11.1065 10.8314 0 0 9.14537 0 11.6723 11.7901 12.9824 11.5994 11.3445 9.61528 Q08174 PCDH1_HUMAN Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVVKVSDR;YFLQTTTPLDYEK 2 2 0.91107 -0.31909 0 0 0 0 0 10.6369 0 10.2954 0 0 0 0 Q08188 TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain] TGM3 Homo sapiens (Human) hair follicle morphogenesis [GO:0031069]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; protein-containing complex [GO:0032991] acyltransferase activity [GO:0016746]; calcium ion binding [GO:0005509]; catalytic activity [GO:0003824]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural molecule activity [GO:0005198] EVNLVLLLK;VAGMLAVGKEVNLVLLLKNLSR;VPDESEVVVERDIILDNPTLTLEVLNEAR 3 7.4 0.95195 -0.71338 10.67 0 0 0 0 0 10.1157 9.87195 0 0 0 0 Q08211 DHX9_HUMAN ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) DHX9 DDX9 LKP NDH2 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; protein localization to cytoplasmic stress granule [GO:1903608]; protein-containing complex assembly [GO:0065003]; pyroptotic inflammatory response [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]" actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] 3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142] AENNSEVGASGYGVPGPTWDR;AVGNKNR;AVGNKNRQK;DINTDFLLVVLRDVVQAYPEVR;DVVQAYPEVR;EGETVEPYK;ELDALDANDELTPLGR;ILTTEGR;ISAVSVAER;LAAQSCALSLVR;LAQFEPSQR;LGGIGQFLAK;LNMATLR;LNQYFQK;NELMYQLEQDHDLQAILQER;QPAIISQLDPVNER;SSVNCPFSSQDMK;VFDPVPVGVTK 18 15.4 0 20.824 11.7907 12.6762 7.40905 10.1618 8.70549 10.3243 9.84955 11.9437 12.1095 13.0737 11.0174 10.2104 Q08257 QOR_HUMAN Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Homo sapiens (Human) protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270] EVNYIDK 1 2.1 0.78574 0.024914 12.5544 12.5044 12.7088 10.5614 10.6019 9.71522 9.43077 0 10.3781 14.0909 14.0242 11.0829 Q08289 CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) CACNB2 CACNLB2 MYSB Homo sapiens (Human) calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; neuromuscular junction development [GO:0007528]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; positive regulation of muscle contraction [GO:0045933]; protein localization to plasma membrane [GO:0072659]; regulation of heart rate by cardiac conduction [GO:0086091]; visual perception [GO:0007601] L-type voltage-gated calcium channel complex [GO:1990454]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; voltage-gated calcium channel complex [GO:0005891] actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626] QETFDSETQESRDSAYVEPK 1 3 0.91817 -0.43484 0 0 0 0 0 0 0 0 0 0 6.97304 0 Q08334 I10R2_HUMAN Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b) IL10RB CRFB4 D21S58 D21S66 Homo sapiens (Human) cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-10-mediated signaling pathway [GO:0140105]; positive regulation of cellular respiration [GO:1901857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; signal transduction [GO:0007165]; type III interferon-mediated signaling pathway [GO:0038196] interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; interleukin-10 receptor activity [GO:0004920]; signaling receptor activity [GO:0038023] IFQDKCMNTTLTECDFSSLSK;NVYNSWTYNVQYWK;NVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLR 3 16.6 0.91671 -0.34419 0 3.55925 0 10.4755 0 0 0 0 0 0 0 8.34319 Q08345 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE Homo sapiens (Human) "axon development [GO:0061564]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; ear development [GO:0043583]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of cell population proliferation [GO:0008285]; neuron projection extension [GO:1990138]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of cell growth [GO:0001558]; regulation of cell-matrix adhesion [GO:0001952]; regulation of extracellular matrix disassembly [GO:0010715]; smooth muscle cell migration [GO:0014909]; smooth muscle cell-matrix adhesion [GO:0061302]; wound healing, spreading of cells [GO:0044319]" extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; collagen binding [GO:0005518]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GHPLLVAVKILRPDATK;GQQPVAK;VARFLQCR;YLATLNFVHRDLATR 4 5.1 0.97327 -2.6302 0 10.562 0 7.80329 0 10.3198 0 0 0 0 0 0 Q08378 GOGA3_HUMAN Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) GOLGA3 Homo sapiens (Human) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296] AQLQLLQK;EPLKNLNSCLQQLK;LEEFEGERERLQR;WEVDQKER 4 2.9 0.97684 -1.4966 0 0 11.6111 0 8.79194 0 0 0 9.80434 0 0 0 Q08379 GOGA2_HUMAN Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) GOLGA2 Homo sapiens (Human) asymmetric cell division [GO:0008356]; centrosome cycle [GO:0007098]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; meiotic spindle assembly [GO:0090306]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; negative regulation of autophagy [GO:0010507]; negative regulation of protein binding [GO:0032091]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein homotetramerization [GO:0051289]; protein transport [GO:0015031]; spindle assembly [GO:0051225] cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; syntaxin binding [GO:0019905] ALQGAMEK;EEKECSMSR 2 1.7 0.95996 -1.0533 0 0 7.03243 0 0 9.26896 6.09833 0 0 3.75958 0 0 Q08380 LG3BP_HUMAN Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K) LGALS3BP M2BP Homo sapiens (Human) cell adhesion [GO:0007155]; cellular defense response [GO:0006968]; signal transduction [GO:0007165] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet dense granule lumen [GO:0031089] scavenger receptor activity [GO:0005044] SDLAVPSELALLK;SLGWLKSNCRHER 2 4.4 0.85262 -0.079944 0 0 0 0 5.82576 0 0 0 0 10.5106 0 0 Q08397 LOXL1_HUMAN Lysyl oxidase homolog 1 (EC 1.4.3.13) (Lysyl oxidase-like protein 1) (LOL) LOXL1 LOXL Homo sapiens (Human) aorta development [GO:0035904]; collagen fibril organization [GO:0030199]; protein deamination [GO:0018277]; response to lipopolysaccharide [GO:0032496] acrosomal vesicle [GO:0001669]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] FPQRVKNQGTADFLPNRPR;NGAQQGR 2 4.5 0.13813 0.35305 0 0 0 0 0 0 0 11.7222 0 0 8.22988 0 Q08426 ECHP_HUMAN "Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]" EHHADH ECHD Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] "3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; enzyme binding [GO:0019899]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]" IGVVVGNCFGFVGNR;MGPFRVSDLAGLDVGWK;TISQDEILER;YRKTHHIEPR 4 7.2 0.95129 -0.68887 10.0564 0 0 0 8.65564 10.7279 0 0 0 0 6.31667 0 Q08431 MFGM_HUMAN Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] MFGE8 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; single fertilization [GO:0007338] acrosomal membrane [GO:0002080]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020] integrin binding [GO:0005178]; phosphatidylserine binding [GO:0001786] IALRLELLGC 1 2.6 0.88625 -0.18186 0 0 0 0 0 0 9.88503 0 0 0 0 0 Q08493 PDE4C_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) (cAMP-specific phosphodiesterase 4C)" PDE4C DPDE1 Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] cilium [GO:0005929]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" IMQAPVPHSQR;VTAEEAPQPMSR 2 3.2 0.92829 -0.47284 0 0 0 0 0 6.24317 11.336 0 0 0 0 0 Q08495 DEMA_HUMAN Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) DMTN DMT EPB49 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament capping [GO:0051693]; cellular response to cAMP [GO:0071320]; cytoskeleton organization [GO:0007010]; endoplasmic reticulum tubular network organization [GO:0071786]; erythrocyte development [GO:0048821]; lamellipodium assembly [GO:0030032]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of wound healing [GO:0090303]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell projection membrane [GO:0031253]; cortical cytoskeleton [GO:0030863]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; smooth endoplasmic reticulum [GO:0005790]; spectrin-associated cytoskeleton [GO:0014731] actin binding [GO:0003779]; actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507] GAEEEEEEEDDDSGEEMK;RGAEEEEEEEDDDSGEEMK;TKLPPGVDR 3 6.9 0.71531 0.14217 0 9.77538 6.99345 0 0 0 0 0 0 6.11639 0 7.04581 Q08499 PDE4D_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)" PDE4D DPDE3 Homo sapiens (Human) adrenergic receptor signaling pathway [GO:0071875]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; establishment of endothelial barrier [GO:0061028]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of heart contraction [GO:0045822]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of relaxation of cardiac muscle [GO:1901898]; positive regulation of heart rate [GO:0010460]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of type II interferon production [GO:0032729]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; T cell receptor signaling pathway [GO:0050852] apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; ATPase binding [GO:0051117]; beta-2 adrenergic receptor binding [GO:0031698]; calcium channel regulator activity [GO:0005246]; cAMP binding [GO:0030552]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; signaling receptor regulator activity [GO:0030545]; transmembrane transporter binding [GO:0044325]" ENLLQHEKSKTAR;LSPVISPR 2 2.8 0.39027 0.21386 0 3.74825 0 0 0 0 0 0 0 9.84431 9.07647 0 Q08554 DSC1_HUMAN Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3) DSC1 CDHF1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; desmosome maintenance [GO:0002160]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of epithelial cell proliferation [GO:0050680] cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EPFNLFYIEK;HCEDYVCSYNYEGK;VCDCSTPSECR 3 3.9 0.9412 -0.60269 0 2.77066 0 0 0 0 0 6.32702 9.55482 0 0 0 Q08623 HDHD1_HUMAN Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase) PUDP DXF68S1E FAM16AX GS1 HDHD1 HDHD1A Homo sapiens (Human) nucleotide metabolic process [GO:0009117] cytosol [GO:0005829] metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pseudouridine 5'-phosphatase activity [GO:1990738] GLQSRWTDTER 1 4.4 0.97939 -1.5363 0 0 0 0 0 0 0 0 9.87191 0 0 0 Q08629 TICN1_HUMAN Testican-1 (Protein SPOCK) SPOCK1 SPOCK TIC1 TICN1 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528] calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; extracellular matrix structural constituent [GO:0005201]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867] SLLGAFIPR 1 2.1 0.93218 -0.49281 0 12.0011 11.9179 0 0 0 0 7.95797 0 12.9262 0 0 Q08722 CD47_HUMAN Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47) CD47 MER6 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATP export [GO:1904669]; cell migration [GO:0016477]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of phagocytosis [GO:0050765]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell activation [GO:0050870]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] cell-cell adhesion mediator activity [GO:0098632]; fibrinogen binding [GO:0070051]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; thrombospondin receptor activity [GO:0070053] AVEEPLNAFKESKGMMNDE 1 5.9 0.86244 -0.082939 0 0 0 0 0 0 0 0 0 0 0 10.7243 Q08752 PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) PPID CYP40 CYPD Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to UV-A [GO:0071492]; chaperone-mediated protein folding [GO:0061077]; lipid droplet organization [GO:0034389]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclosporin A binding [GO:0016018]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; nuclear estrogen receptor binding [GO:0030331]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; transcription factor binding [GO:0008134] GIGHTTGKPLHFKGCPFHR;ILENVEVK;SQNWEMAIK 3 9.7 0.93322 -0.50642 0 0 12.9457 0 0 0 0 0 10.5801 0 0 10.1762 Q08828 ADCY1_HUMAN Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; axonogenesis [GO:0007409]; cAMP biosynthetic process [GO:0006171]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; circadian rhythm [GO:0007623]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of long-term synaptic potentiation [GO:1900273]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of circadian rhythm [GO:0042752]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] AAGTSRR;AEIPFSNVMTCEDDDK;MKFKTVCYLLVQLMHCR;TDGNGSQIR;THNIETFFIVPSHR;TIGSTYMAAVGLAPTSGTKAK;TVCYLLVQLMHCRKMFK 7 7.9 0.95497 -0.93936 0 6.45431 0 9.27868 8.57747 0 10.2776 0 0 0 9.14825 0 Q08881 ITK_HUMAN Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) ITK EMT LYK Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; gamma-delta T cell activation [GO:0046629]; intracellular signal transduction [GO:0035556]; NK T cell differentiation [GO:0001865]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] ETNDNPK;HYHIKETNDNPKR;SPNNLETYEWYNKSISR 3 4.8 0.98025 -1.5509 0 7.8132 0 0 0 0 10.7239 10.2759 0 0 0 0 Q08945 SSRP1_HUMAN FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) SSRP1 FACT80 Homo sapiens (Human) DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of chromatin organization [GO:1902275] FACT complex [GO:0035101]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] AETLEFNDVYQEVK;ASSGLLYPLER;DEDISLTLNMNEEEVEK;FEGRLTKNMSGSLYEMVSR;FYVPPTQEDGVDPVEAFAQNVLSK;QLSESFKSK 6 13.3 0 21.205 0 0 12.9072 11.2512 9.34076 0 0 0 11.6221 9.96446 9.67053 0 Q08999 RBL2_HUMAN Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) RBL2 RB2 Homo sapiens (Human) cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] EHFWKPYIRKLYEK;EINSMIRTGETPTK;EKIFYYFSNSPSK;FDELCSRLNMDEAARAEAWDSYR;GLSEDFHAK;SVPTVSK 6 7 0.97508 -3.1476 12.9067 0 10.7121 0 0 0 0 0 12.1187 8.6664 0 0 Q08AD1 CAMP2_HUMAN Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) CAMSAP2 CAMSAP1L1 KIAA1078 Homo sapiens (Human) axon development [GO:0061564]; cytoplasmic microtubule organization [GO:0031122]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of dendrite development [GO:0050773]; regulation of Golgi organization [GO:1903358]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule end [GO:1990752] calmodulin binding [GO:0005516]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] ADVPVEK;GLYVTDQEK;GTLEQRGHNPEEK;MIEGLYK;MTSFAEQK 5 3 0.97387 -3.0382 10.7424 0 0 0 0 0 7.50048 0 0 0 0 10.2372 Q08AE8 SPIR1_HUMAN Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; innate immune response [GO:0045087]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin binding [GO:0003779]; microtubule binding [GO:0008017] ELMEDWSTMEVCVDCKK;LCAAHLPTESDAPNHYQAVCR;LKPTPPRPR 3 6.2 0.91774 -0.40094 0 0 8.77873 0 0 0 0 0 0 0 3.83754 0 Q08AG5 ZN844_HUMAN Zinc finger protein 844 ZNF844 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QCGKALSYLNFQRHMK 1 2.4 0.8496 -0.075669 0 0 0 0 0 0 0 0 0 8.96921 0 0 Q08AH1 ACSM1_HUMAN "Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B)" ACSM1 BUCS1 LAE MACS1 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; benzoate metabolic process [GO:0018874]; butyrate metabolic process [GO:0019605]; cholesterol homeostasis [GO:0042632]; energy derivation by oxidation of organic compounds [GO:0015980]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; xenobiotic metabolic process [GO:0006805] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872] SLSEFGAPR;TGIIFIPATILLKAK 2 4.2 0.9283 -0.46019 0 0 0 0 0 10.1944 0 0 0 0 4.53518 10.9628 Q08AM6 VAC14_HUMAN Protein VAC14 homolog (Tax1-binding protein 2) VAC14 TAX1BP2 TRX Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; PAS complex [GO:0070772]; presynaptic endosome [GO:0098830] identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] ELIEPVLTCFNDADSRLR;LQCVPNPELLQTEDSLK 2 4.5 0.91792 -0.40793 0 0 0 0 0 9.02661 8.85599 0 0 0 0 0 Q08AN1 ZN616_HUMAN Zinc finger protein 616 ZNF616 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CLEPVQKALYKDVMLENYR;HSHLAVHWR;IHTGEKRYK;SNLVCHRR 4 5.8 0.97334 -2.4791 0 0 0 0 0 0 0 9.80106 13.571 0 0 0 Q08ER8 ZN543_HUMAN Zinc finger protein 543 ZNF543 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGIGPQRGKLLEK;NSYKCEECGK 2 3.8 0.96547 -1.1441 0 0 0 0 0 0 9.84594 0 0 10.3612 0 0 Q08J23 NSUN2_HUMAN "RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)" NSUN2 SAKI TRM4 Homo sapiens (Human) cell division [GO:0051301]; hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; mRNA processing [GO:0006397]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049] DGQWFTDWDAVPHSR;GAEQLAEGGR;ILCDVPCSGDGTMRK;KDGVCGPPPSK;KDGVCGPPPSKK;NERLHYLRMMGLEVLGEK 6 9.1 0.96533 -1.1379 8.19298 0 11.1267 0 5.25546 0 0 0 0 9.05943 0 11.2373 Q09013 DMPK_HUMAN Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase) DMPK DM1PK MDPK Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; muscle cell apoptotic process [GO:0010657]; nuclear envelope organization [GO:0006998]; protein phosphorylation [GO:0006468]; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction [GO:0014853]; regulation of heart contraction [GO:0008016]; regulation of myotube differentiation [GO:0010830]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; myosin phosphatase regulator activity [GO:0017020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LLCPPETR 1 1.3 0.93587 -0.53686 0 0 0 0 0 0 0 0 0 0 0 10.5723 Q09019 DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) DMWD DM9 Homo sapiens (Human) cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204] deubiquitinase activator activity [GO:0035800] AGSITYR;ELYFYPGCCR 2 2.5 0.94091 -0.58865 0 0 6.54076 11.3099 0 0 0 0 0 0 0 0 Q09028 RBBP4_HUMAN Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) RBBP4 RBAP48 Homo sapiens (Human) brain development [GO:0007420]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736] "ATPase complex [GO:1904949]; CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]" histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ADKEAAFDDAVEER;INHEGEVNR;TPSSDVLVFDYTK;TVALWDLR 4 10.4 0.045614 0.49401 0 0 0 0 0 0 9.0877 8.6271 8.78172 9.29854 0 0 Q09161 NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) NCBP1 CBP80 NCBP Homo sapiens (Human) "7-methylguanosine mRNA capping [GO:0006370]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of RNA binding [GO:1905216]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of mRNA processing [GO:0050684]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA cap binding complex [GO:0034518] molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] ATNDEIFSILK;KMNKHVLK;VESAQSEQK 3 3.5 0.9784 -1.9753 0 11.6093 13.3498 0 0 0 0 0 0 13.1894 12.1753 0 Q09327 MGAT3_HUMAN "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III)" MGAT3 GGNT3 Homo sapiens (Human) amyloid-beta metabolic process [GO:0050435]; cellular response to oxidative stress [GO:0034599]; cognition [GO:0050890]; N-acetylglucosamine metabolic process [GO:0006044]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of protein localization to early endosome [GO:1902966]; protein localization [GO:0008104]; protein N-linked glycosylation [GO:0006487]; regulation of cell migration [GO:0030334] Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0003830]; glycosyltransferase activity [GO:0016757]" GPEGRPPAR;GPEGRPPARGK;LVSAQNGDFPRWGDYEDK 3 5.4 0.96513 -1.2199 8.03645 0 0 0 0 0 0 0 0 11.7948 11.8199 0 Q09328 MGT5A_HUMAN "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V) [Cleaved into: Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (Secreted beta-1,6-N-acetylglucosaminyltransferase V) (Secreted GNT-V)]" MGAT5 GGNT5 Homo sapiens (Human) positive regulation of cell migration [GO:0030335]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]; protein phosphatase inhibitor activity [GO:0004864]" AKNPYEEADHNSLAEIR;ISASLAELK;LAEPGQSCK;SLAEKQNLEK;WMKDMWR 5 7 0.97599 -5.1727 8.87664 0 0 0 0 11.2364 0 0 0 0 11.0954 0 Q09428 ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) ABCC8 HRINS SUR SUR1 Homo sapiens (Human) "action potential [GO:0001508]; cellular response to nutrient levels [GO:0031669]; female pregnancy [GO:0007565]; glutamate secretion, neurotransmission [GO:0061535]; inorganic cation transmembrane transport [GO:0098662]; intracellular glucose homeostasis [GO:0001678]; memory [GO:0007613]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of insulin secretion [GO:0046676]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuroblast migration [GO:0061855]; neuromuscular process [GO:0050905]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of uterine smooth muscle relaxation [GO:1900721]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]" inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672] ABC-type transporter activity [GO:0140359]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325] AEIPWRACAK;ETATDLDIR;GAILEFDKPEK;GQLTMIVGQVGCGK;KDSVFASFVR;NLADMELQLGAVK;TVVLVTHK;VAKRLHR 8 5.2 0.97247 -2.7451 0 11.9082 0 0 0 0 12.6905 10.8699 9.4537 0 9.2546 0 Q09470 KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1) KCNA1 Homo sapiens (Human) action potential [GO:0001508]; axon development [GO:0061564]; cell communication by electrical coupling [GO:0010644]; cellular response to magnesium ion [GO:0071286]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; hippocampus development [GO:0021766]; magnesium ion homeostasis [GO:0010960]; membrane repolarization during action potential [GO:0086011]; neuroblast proliferation [GO:0007405]; neuromuscular process [GO:0050905]; neuronal action potential [GO:0019228]; neuronal signal transduction [GO:0023041]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937]; startle response [GO:0001964] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; disordered domain specific binding [GO:0097718]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] LRRPVNVPLDMFSEEIK;MRYFDPLR;VIRLVRVFR 3 6.9 0.98165 -1.58 0 0 0 0 0 0 0 9.85357 9.73054 0 0 0 Q09472 EP300_HUMAN Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) EP300 P300 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to L-leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine butyrylation [GO:0140067]; peptidyl-lysine crotonylation [GO:0140066]; peptidyl-lysine propionylation [GO:0061921]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of cellular response to heat [GO:1900034]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; swimming [GO:0036268]; thigmotaxis [GO:0001966]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "acetylation-dependent protein binding [GO:0140033]; acetyltransferase activity [GO:0016407]; acyltransferase activity [GO:0016746]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone butyryltransferase activity [GO:0140069]; histone crotonyltransferase activity [GO:0140068]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2B acetyltransferase activity [GO:0044013]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K16 propionyltransferase activity [GO:0141002]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; NF-kappaB binding [GO:0051059]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; pre-mRNA intronic binding [GO:0097157]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; tau protein binding [GO:0048156]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" QCNLPHCRTMK;RKLIQQQLVLLLHAHK;VVHASDK 3 1.4 0.95599 -0.84566 0 0 0 0 0 0 8.36326 0 8.72448 0 0 9.08733 Q09666 AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK (Desmoyokin) AHNAK PM227 Homo sapiens (Human) positive regulation of plasma membrane repair [GO:1905686]; regulation of RNA splicing [GO:0043484]; regulation of voltage-gated calcium channel activity [GO:1901385] actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493] ADIEISGPK;ADLDVSGPK;ADLGVSGPK;ADVDISGPK;ADVDVSGPK;AEGPEVDVNLPK;DIDISSPEFK;EVDVNLPK;FGVSTGR;FKMPSMNIQTHK;FSLFKSKKPR;FSMPGFK;FSMPSLK;FSVPGFK;GDVDVSLPK;GDVDVSVPK;GDVDVTLPK;GEGPDGDVK;GEGPEVDVNLPK;GGVQVPAVDISSSLGGR;GGVTGSPEASISGSK;GPELDVK;GPEVDLK;GPKVDIDAPDVEVHDPDWHLKMPK;GPKVDIK;GPKVKGDADVSVPK;GPQVALK;IGIPGVK;IKGDVDVTGPKVEGDLK;ISMPDFDLNLK;ISMPDIDFNLKGPK;ISMPDLDLNLKGPK;ISMPDVDLHMKGPK;ISMPDVDLNLK;ISMPGFK;ISMQDVDLSLGSPK;LDADMPEVAVEGPNGK;LGSPSGKTGTCR;LPTGQISGPEIK;MKLPQFGISTPGSDLHVNAK;MPKFSMPGFK;VDIDAPDVDVHGPDWHLK;VDIDVPDVNIEGPDAK;VDIDVPDVNLEAPEGK;VDIEGPDVNIEGPEGK;VDINAPDVEVQGK;VDTNAPDLSLEGPEGK;VDVDIPDVNIEGPDAK;VDVDVPDVNIEGPDAK;VDVEVPDVSLEGPEGK;VEGDLKGPEIDVK;VEGDLKGPEVDIR;VEGDLKGPEVDLK;VEGEMKVPDVDIK;VGGSGVNVNAK;VGIDTPDIDIHGPEGK;VKGEYDVTVPK;VNVEAPDVNLEGLGGK;VPDVDIK;VPDVELK;VSAPGVQGDVK;VTAYTVDVTGREGAK;VTFPKMK;VTFPKMKIPK 64 24 0 9.3834 13.9178 14.147 14.4841 13.3393 12.8155 10.99 14.3571 14.9336 14.5395 14.8241 14.5277 13.6299 Q09FC8 ZN415_HUMAN Zinc finger protein 415 ZNF415 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHDFDCQWRDDER;QVSHSGEK;TLYRDVMLENYR;VFSQKSNLAR 4 7.7 0.98027 -1.8273 0 10.114 10.1167 0 0 0 0 0 10.609 0 0 0 Q09MP3 R51A2_HUMAN RAD51-associated protein 2 RAD51AP2 Homo sapiens (Human) protein-containing complex [GO:0032991] DCETPLPK;DFTNIYWSQNRPDVKK;ENPFLDVTFYK;IRASSSFHDTIAGPNMGK;LFRTEQVFEKSK;SPFHEIKNRCK;TKCENMKK;VTAESLTNSCQVHK;VTAESLTNSCQVHKDTKIEK 9 9 0.97607 -5.2429 0 0 0 9.5889 6.7786 4.94528 11.063 0 0 8.67387 0 0 Q0D2I5 IFFO1_HUMAN Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103) IFFO1 IFFO Homo sapiens (Human) DNA double-strand break attachment to nuclear envelope [GO:1990683]; double-strand break repair via nonhomologous end joining [GO:0006303]; protein localization to site of double-strand break [GO:1990166] intermediate filament [GO:0005882]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] KLVPSMGGRK;QLQQALEEGK;WEEEYTVRIQLQDR 3 6 0.97563 -2.3238 0 0 0 0 9.42169 0 11.2135 0 0 0 0 0 Q0D2J5 ZN763_HUMAN Zinc finger protein 763 ZNF763 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ALSYKFSNTPK 1 2.8 0.92091 -0.44368 0 10.9081 3.47547 0 0 8.67916 0 0 0 0 0 0 Q0D2K5 EGFEM_HUMAN Putative EGF-like and EMI domain-containing protein 1 EGFEM1P C3orf50 NCRNA00259 Homo sapiens (Human) scavenger receptor activity [GO:0005044] KSCTILRCISLTNLALSR;WYHITVCLDHIFGHNCSLSCK 2 20 0.74503 0.086822 0 0 3.57688 0 6.0947 0 0 0 0 5.15166 0 0 Q0GE19 NTCP7_HUMAN Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) SLC10A7 C4orf13 P7 PSEC0051 Homo sapiens (Human) bone development [GO:0060348]; heparin biosynthetic process [GO:0030210]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] symporter activity [GO:0015293] KPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDK;LLERMRK 2 11.8 0.68233 0.16545 0 0 0 0 4.96264 5.89188 0 0 0 0 0 0 Q0GE19 NTCP7_HUMAN Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) SLC10A7 C4orf13 P7 PSEC0051 Homo sapiens (Human) bone development [GO:0060348]; heparin biosynthetic process [GO:0030210]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] symporter activity [GO:0015293] AVGGNEAAAIFNSAFGSFLVSK;LLERMRK 2 18.2 0.96228 -1.0689 0 0 0 0 0 0 0 0 0 0 0 9.89806 Q0IIM8 TBC8B_HUMAN TBC1 domain family member 8B TBC1D8B Homo sapiens (Human) glomerular filtration [GO:0003094]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] GIPETLR;GLIAEEGKHCFAKEDDPEK;VVSQDVKLSLQELDELYVIFKK 3 4.3 0.92961 -0.4699 0 7.19367 0 0 0 0 9.28179 0 9.30033 0 0 0 Q0IIN9 ZNFS1_HUMAN Putative uncharacterized protein ZNF252P-AS1 (ZNF252P antisense RNA 1) (ZNF252P antisense gene protein 1) ZNF252P-AS1 C8orf77 Homo sapiens (Human) GALSPSLGRLFPHLQVVIKLR;LQWDSGSIK 2 14.2 0.92158 -0.44302 0 0 0 0 0 6.75889 0 0 0 0 0 0 Q0JRZ9 FCHO2_HUMAN F-BAR domain only protein 2 FCHO2 Homo sapiens (Human) clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" VMAYFVENFWGEK 1 1.6 0.76473 0.060266 0 0 4.52607 0 3.27422 0 0 4.69505 0 0 0 0 Q0P5N6 ARL16_HUMAN ADP-ribosylation factor-like protein 16 ARL16 Homo sapiens (Human) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ALSRGAELRVPGGAK;LPDIIACAKQNITTAEISAR 2 17.8 0.90456 -0.27019 0 0 4.74281 0 0 0 0 0 10.0143 0 0 5.30633 Q0P651 ABD18_HUMAN Protein ABHD18 (Alpha/beta hydrolase domain-containing protein 18) (Abhydrolase domain-containing protein 18) ABHD18 C4orf29 Homo sapiens (Human) extracellular region [GO:0005576]; mitochondrion [GO:0005739] TSVSATSEGLLLQDTSK 1 4.1 0.781 0.033329 0 0 10.4715 0 0 0 0 0 0 0 0 0 Q0P670 SPEM2_HUMAN Uncharacterized protein SPEM2 SPEM2 C17orf74 Homo sapiens (Human) membrane [GO:0016020] NPGGNANYQVYDSLELKR;QIPHSHSVFRNPHRSQK 2 7 0.10106 0.36778 0 0 7.09191 0 0 0 8.7284 0 0 0 0 0 Q0P6D2 DIK1C_HUMAN Divergent protein kinase domain 1C (Protein FAM69C) DIPK1C C18orf51 FAM69C Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] EILEQNCTGDEDCNFFDCFSR 1 17.5 0.65348 0.16939 0 0 0 0 6.88753 0 0 0 0 0 0 0 Q0P6D6 CCD15_HUMAN Coiled-coil domain-containing protein 15 CCDC15 Homo sapiens (Human) centrosome [GO:0005813] EQQRQKEQK;LPLALNPLK 2 1.9 0.91399 -0.33565 0 0 11.4411 0 0 0 0 0 0 5.91464 0 0 Q0P6H9 TMM62_HUMAN Transmembrane protein 62 TMEM62 Homo sapiens (Human) membrane [GO:0016020] hydrolase activity [GO:0016787] TDHYIMAR;TWLTLLTPVLIR;VLFVLIVLSQLTILIIFR 3 5.9 0.89165 -0.216 7.54813 5.31081 3.614 0 0 0 8.01391 0 0 0 0 0 Q0VAA2 LR74A_HUMAN Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) FFTTGQK;ISKGLESNESLR;ISKGLESNESLRVLK;MSVDEFQK;TIFLLTNPMK;TLDGVYAVHPQLDVVFK 6 11.7 0.98157 -1.7706 0 8.31854 0 9.38632 0 0 12.3895 0 13.1817 0 0 9.66363 Q0VAA5 PLCX2_HUMAN PI-PLC X domain-containing protein 2 (Phospholipase C X-domain containing protein 2) (PLCXD-2) PLCXD2 Homo sapiens (Human) lipid catabolic process [GO:0016042]; signal transduction [GO:0007165] nucleus [GO:0005634] phosphoric diester hydrolase activity [GO:0008081] GLVGGLK 1 2.3 0.5465 0.18348 0 0 0 9.54988 0 0 0 0 0 0 12.44 0 Q0VAK6 LMOD3_HUMAN "Leiomodin-3 (Leiomodin, fetal form)" LMOD3 Homo sapiens (Human) actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of skeletal muscle fiber development [GO:0048743]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865] actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523] DQTDKPPTGNFNHK 1 2.5 0.783 0.023298 0 0 0 0 0 0 0 0 10.1303 0 0 0 Q0VAM2 RGF1B_HUMAN Ras-GEF domain-containing family member 1B (GPI gamma-4) RASGEF1B GPIG4 Homo sapiens (Human) Ras protein signal transduction [GO:0007265] early endosome [GO:0005769]; late endosome [GO:0005770]; midbody [GO:0030496]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DERMMRNLK;ISSTSTDRLTVLK;LPNGHVNFEKFWELAK;TALRGAAQR 4 9.9 0.97474 -3.2455 0 5.91655 0 0 0 9.12099 0 0 0 7.03782 0 0 Q0VD83 APOBR_HUMAN Apolipoprotein B receptor (Apolipoprotein B-100 receptor) (Apolipoprotein B-48 receptor) (Apolipoprotein B48 receptor) (apoB-48R) APOBR APOB48R Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; triglyceride metabolic process [GO:0006641] chylomicron [GO:0042627]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] very-low-density lipoprotein particle receptor activity [GO:0030229] EEADLLGVRQTEYGAVPGER;EQREDSEGRCGDYHPEGEAPR;ETEDEEAEADRTSR;IVEEEAQEDLEGLR;SLEAGPR;WEDRLRPGVRDQPGQHSK 6 8.7 0.97234 -2.8063 0 0 0 6.49419 6.77979 0 8.37138 12.2354 0 8.16591 10.3563 10.2577 Q0VD86 INCA1_HUMAN Protein INCA1 (Inhibitor of CDK interacting with cyclin A1) INCA1 HSD45 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic signaling pathway [GO:2001235] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] AVTYHLEDLRR 1 4.7 0.88085 -0.15343 0 0 0 0 0 0 0 0 0 0 10.1271 0 Q0VDD8 DYH14_HUMAN Dynein axonemal heavy chain 14 (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14) DNAH14 C1orf67 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AILGALLILYVHCRDIVINLLLK;DENTWYPEKNPDKLTK;IISQSGVDCLEFMIK;ITLKKPLEDDGEFVYCLPRK;LEKEFLTMSQLYSVAK;LKSRISDLSNVFK;LLFSLCFFNAVINERK;LLLSETGFLKKLINLDK;QLEDIRNK;SIFKVVSSALFNEDKLCFSFR;TKETETLMEK;TLLYKFCNPEVLK;TLLYKFCNPEVLKDDFSFSR;VAYTAIQRRYMR;VDICVLNPK;VFVKLKK;VQMLVKQDEEIVAEEVR;VQMLVKQDEEIVAEEVRIVEDYAQK;VTYDFDK 19 5.6 0.97841 -7.2643 12.3708 11.331 4.8711 12.2717 9.42526 7.17103 10.4232 12.2949 12.2418 11.3396 9.43796 0 Q0VDE8 ADIG_HUMAN Adipogenin ADIG Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; positive regulation of fat cell differentiation [GO:0045600]; spermatogenesis [GO:0007283]; white fat cell differentiation [GO:0050872] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634] GPAEFCWKGTLHGQEK 1 20 0.81235 -0.013541 0 0 0 0 0 0 8.4793 0 0 0 0 0 Q0VDF9 HSP7E_HUMAN Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) (Heat shock protein family A member 14) HSPA14 HSP60 HSP70L1 Homo sapiens (Human) 'de novo' cotranslational protein folding [GO:0051083]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183] FTVLFPSGTPLPAR;SNILVFK 2 4.1 0.93773 -0.56075 0 0 5.95124 8.5651 8.25437 0 0 0 0 0 0 0 Q0VF49 K2012_HUMAN Uncharacterized protein KIAA2012 KIAA2012 Homo sapiens (Human) AEAEKQR;CEDPSKALLTK;IDHSWLPSDK;QLQQEQLERAK 4 3.3 0.97475 -3.6817 0 13.5624 0 0 0 8.59582 12.4737 0 0 0 0 0 Q0VF96 CGNL1_HUMAN Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) CGNL1 JACOP KIAA1749 Homo sapiens (Human) actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991] ELAEMQRQLKEK;KQTSVCVNVQSCTKER;LESEERDR;LLQEENEKLQGR;LMEEELRDYQR;NLKQPLLHEGK;TLEAEKSRLTAMK 7 6.4 0.97654 -4.962 0 9.72397 8.98496 11.3584 0 7.66818 12.1703 8.64944 0 9.10006 0 0 Q0VFZ6 CF210_HUMAN Cilia- and flagella- associated protein 210 (Coiled-coil domain-containing protein 173) CFAP210 C2orf77 CCDC173 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126] AIVMKNK;AVQEGPGGGR;LDNEDMIIARDIAEAEAEWEK;QYQFYQTERVKNFHSGLLLSR 4 10.7 0.91146 -0.32483 0 9.86525 0 0 0 9.26571 9.97814 0 0 9.45748 0 0 Q0VG06 FP100_HUMAN Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa) FAAP100 C17orf70 Homo sapiens (Human) interstrand cross-link repair [GO:0036297] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] LLYALCAR;MAGAAPR 2 1.7 0.89765 -0.23388 0 0 0 0 0 0 0 0 11.7118 10.7193 10.6809 11.9886 Q0VGE8 ZN816_HUMAN Zinc finger protein 816 ZNF816 ZNF816A Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;CLNPAQR;CNECGKTFSQK;IFNQKQYIVYHHRCHTGEK;IHTGEGSYKCKVCDK;ISNQLDK;LTGSTDR 7 11.7 0.96405 -1.184 0 0 8.09133 8.70715 0 0 0 0 0 0 8.31438 0 Q0Z7S8 FABP9_HUMAN Fatty acid-binding protein 9 (Testis lipid-binding protein) (TLBP) (Testis-type fatty acid-binding protein) (T-FABP) FABP9 Homo sapiens (Human) long-chain fatty acid transport [GO:0015909] cytosol [GO:0005829]; nucleus [GO:0005634] long-chain fatty acid binding [GO:0036041] MNNIVSTRIYEK 1 9.1 0.92608 -0.45247 0 0 0 0 6.73091 0 0 0 0 0 0 0 Q0ZGT2 NEXN_HUMAN Nexilin (F-actin-binding protein) (Nelin) NEXN Homo sapiens (Human) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cell-cell adhesion mediator activity [GO:0098632]; structural constituent of muscle [GO:0008307] AIDLEIK;DKFEAMQR;EEEEQRRIEEQK;EREAENFHEEDDVDVRPAR;IEQDMLEK;IEQDMLEKR 6 8.1 0.91347 -0.33804 0 0 10.1249 0 0 0 0 0 0 0 0 0 Q0ZGT2 NEXN_HUMAN Nexilin (F-actin-binding protein) (Nelin) NEXN Homo sapiens (Human) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cell-cell adhesion mediator activity [GO:0098632]; structural constituent of muscle [GO:0008307] AIDLEIK;EEEEQRRIEEQK;EREAENFHEEDDVDVRPAR;IEQDMLEK;IEQDMLEKR;MNDISQKAEIK 6 9.5 0.97379 -1.4148 0 0 8.29719 10.1483 0 0 0 10.8429 0 10.0788 0 10.7737 Q0ZLH3 PJVK_HUMAN Pejvakin (Autosomal recessive deafness type 59 protein) PJVK DFNB59 Homo sapiens (Human) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044] ETVYGCFQCSVDGQKYVR;HEVEVSTLLKEITTRK;YVRLHAVPCFDIWHK 3 13.1 0.90138 -0.2623 0 0 0 4.09018 8.31777 0 0 0 0 0 9.47102 0 Q10469 MGAT2_HUMAN "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" MGAT2 Homo sapiens (Human) oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]" IFHAGDCGMHHKK;KNEALAPPLLDAEPAR 2 6.5 0.94141 -0.60234 0 0 0 0 0 0 0 0 0 0 9.42924 0 Q10471 GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] GALNT2 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein maturation [GO:0051604]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] KEDWNEIDPIKK;LSCKPFKWYLENVYPELR;SGQDPYAR 3 6.7 0.96376 -1.2037 11.8363 10.8891 11.6545 10.5809 8.08188 10.5879 0 0 0 11.7391 0 0 Q10472 GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] GALNT1 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; viral protein processing [GO:0019082] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] GNQLWEYDPVK;KLKVPVHVIR;LQCKPFSWYLENIYPDSQIPR;TDDLCLDVSK 4 9.3 0.88116 -0.15167 0 0 0 6.59131 0 0 10.1567 0 0 5.28847 0 0 Q10570 CPSF1_HUMAN Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) CPSF1 CPSF160 Homo sapiens (Human) "co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180012]; mRNA processing [GO:0006397]" mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme binding [GO:0019899]; mRNA 3'-UTR AU-rich region binding [GO:0035925] AFRMLHVDRR;EFETIER;KVPHNINFREK;TLSLHYFEEPELR;VDATAGWSAAGK;VITLCLYR;YLYLSTMERSELAK 7 5.2 0.91657 -0.41655 0 11.6033 0 9.91364 0 9.202 12.5076 10.6471 0 8.02951 0 10.3053 Q10586 DBP_HUMAN D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) DBP Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" MARPVSDR 1 2.5 0.93075 -0.47746 0 0 8.61563 0 0 0 0 0 0 0 0 0 Q10587 TEF_HUMAN Thyrotroph embryonic factor TEF KIAA1655 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HKFAEEDLKPQPMIKK;KHKFAEEDLKPQPMIK;SDAGGGK 3 7.9 0.71118 0.15681 0 0 0 0 7.91737 0 0 0 0 0 0 0 Q10587 TEF_HUMAN Thyrotroph embryonic factor TEF KIAA1655 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HKFAEEDLKPQPMIKK;KHKFAEEDLKPQPMIK;SLLEHSLPWPEK 3 10.6 0.25162 0.27668 0 0 11.9398 0 0 0 8.17607 0 0 0 0 0 Q10588 BST1_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157) BST1 Homo sapiens (Human) humoral immune response [GO:0006959]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cellular extravasation [GO:0002691]; regulation of inflammatory response [GO:0050727]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of superoxide metabolic process [GO:0090322]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; uropod [GO:0001931] "NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]" DIFLGRCAEYR;LLQLLLQLLLLLLLLAAGGAR;LLQLLLQLLLLLLLLAAGGARAR;LLQLLLQLLLLLLLLAAGGARARWR 4 11.3 0.91531 -0.36769 0 12.2172 5.74093 0 0 2.95643 8.88996 0 9.31116 0 5.61277 5.58695 Q10589 BST2_HUMAN Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317) BST2 Homo sapiens (Human) B cell activation [GO:0042113]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of plasmacytoid dendritic cell cytokine production [GO:0002737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of actin cytoskeleton organization [GO:0032956]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615] apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] identical protein binding [GO:0042802]; metalloendopeptidase inhibitor activity [GO:0008191]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] MASTSYDYCR 1 5.6 0.81189 0.0019919 0 0 0 0 0 0 3.15932 0 0 0 0 0 Q10713 MPPA_HUMAN Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) PMPCA INPP5E KIAA0123 MPPA Homo sapiens (Human) protein processing involved in protein targeting to mitochondrion [GO:0006627] extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DGRLPRTYR;LAFSSTARFDSK 2 4 0.92839 -0.47059 0 0 0 0 0 0 0 0 0 8.60726 0 0 Q11130 FUT7_HUMAN "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)" FUT7 Homo sapiens (Human) "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; ceramide metabolic process [GO:0006672]; embryo implantation [GO:0007566]; fucosylation [GO:0036065]; inflammatory response [GO:0006954]; L-fucose catabolic process [GO:0042355]; leukocyte migration involved in immune response [GO:0002522]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration into lymph node [GO:0097022]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; regulation of cell adhesion molecule production [GO:0060353]; regulation of cell-cell adhesion [GO:0022407]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236]; regulation of neutrophil extravasation [GO:2000389]; regulation of type IV hypersensitivity [GO:0001807]; T cell migration [GO:0072678]" Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] GIFNWVLSYRR;QLRARLYR 2 5.6 0.96836 -1.3245 0 0 11.6812 0 8.6164 11.2434 0 0 0 0 0 0 Q11201 SIA4A_HUMAN "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)" ST3GAL1 SIAT4 SIAT4A Homo sapiens (Human) "ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; memory B cell differentiation [GO:0002319]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]" extracellular exosome [GO:0070062]; Golgi medial cisterna membrane [GO:1990675]; Golgi membrane [GO:0000139]; Golgi trans cisterna membrane [GO:1990676]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588] "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; sialyltransferase activity [GO:0008373]" LIKHRPCTCTHCIGQRK;QMVLELSENLK 2 8.2 0.91101 -0.3264 0 0 11.585 0 0 0 0 0 0 9.67745 0 0 Q11203 SIAT6_HUMAN "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.3.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6)" ST3GAL3 SIAT6 Homo sapiens (Human) ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]" FSKPAPMFLDDSFRK;LTPALDSLR;TISSERKSFCGSW 3 18.4 0.8684 -0.093294 0 0 0 0 0 0 0 0 0 0 0 7.26426 Q11203 SIAT6_HUMAN "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.3.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6)" ST3GAL3 SIAT6 Homo sapiens (Human) ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]" FSKPAPMFLDDSFRK;ITYPEGAMQRPEQYER;KLLMPASHPLEILK;LTPALDSLR 4 12.2 0.90956 -0.31039 0 11.3318 6.54424 9.97284 10.0272 0 0 0 0 5.75387 0 0 Q12756 KIF1A_HUMAN Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) KIF1A ATSV C2orf20 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde neuronal dense core vesicle transport [GO:1990048]; dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] EEATYLLEQQR;ETEKIIAELNETWEEK;LQELEDQYR;NGATHYWTLEK;QRLDLMREMYDR;VRPFNSREMSRDSK 6 4.3 0.95438 -0.91209 12.7241 12.0583 12.4203 6.41324 9.71124 0 11.346 11.0968 10.9912 11.7421 0 0 Q12766 HMGX3_HUMAN HMG domain-containing protein 3 (HMG box-containing protein 3) (Protein SMF) HMGXB3 KIAA0194 SMF Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] IHGEKTKKPR;LLQEGTCK 2 1.4 0.97669 -2.1893 0 0 0 8.36955 0 0 0 0 0 9.41756 0 0 Q12767 TMM94_HUMAN Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) TMEM94 ERMA KIAA0195 Homo sapiens (Human) intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transport from cytosol to endoplasmic reticulum [GO:0160176] endoplasmic reticulum membrane [GO:0005789] P-type magnesium transporter activity [GO:0015444] DTEGGEEEPSK;LTAALIVLHTVFISITHVHR;NLTNCSSVMLPSNDDR;VLAQMSK 4 4 0.86301 -0.082886 0 0 0 7.72887 0 0 9.45452 7.40914 6.48307 0 0 0 Q12768 WASC5_HUMAN WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin) WASHC5 KIAA0196 Homo sapiens (Human) actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome organization [GO:0007032]; lysosome organization [GO:0007040]; meiotic spindle assembly [GO:0090306]; oocyte maturation [GO:0001556]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503]; regulation of actin nucleation [GO:0051125]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of vesicle size [GO:0097494] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203] ELQNFLSMFQKIILRDR;LQTHDIIEVPTRLDKDK;VDPKQLLEDGIRK 3 4.1 0.22463 0.31378 0 8.2605 0 0 0 0 11.7072 0 0 7.252 0 0 Q12769 NU160_HUMAN Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) NUP160 KIAA0197 NUP120 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] ALECFCQAASEVGK;ALQIFCRGTERNLDLSWSELK;ILDKLEDYQQK;LEDYQQKVDK;LLSTYLERYK;SEDGEIVSTPR 6 4.9 0.97524 -3.6058 0 0 0 0 0 8.9493 0 2.40479 10.2489 9.64805 8.40067 8.14313 Q12770 SCAP_HUMAN Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) SCAP KIAA0199 PSEC0227 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; COPII-coated vesicle cargo loading [GO:0090110]; immune response [GO:0006955]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of fatty acid biosynthetic process [GO:0042304]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to vitamin B3 [GO:0033552]; SREBP signaling pathway [GO:0032933] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SREBP-SCAP complex [GO:0032936] protein-containing complex binding [GO:0044877]; sterol binding [GO:0032934]; unfolded protein binding [GO:0051082] DSPGYDFSCLVQR;FHADPDIIGTIHQHEPK;RMVSYTITLVFQHYHAK 3 3.7 0.74512 0.088596 0 0 9.76833 0 3.90149 0 11.1504 0 0 9.58423 0 0 Q12772 SRBP2_HUMAN Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] SREBF2 BHLHD2 SREBP2 Homo sapiens (Human) cellular response to laminar fluid shear stress [GO:0071499]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitophagy [GO:1901524]; regulation of Notch signaling pathway [GO:0008593]; SREBP signaling pathway [GO:0032933] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP-Insig complex [GO:0032937] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NPADPIAQVHQAFCK 1 1.3 0.78293 0.026146 0 0 0 0 0 9.31574 0 0 0 0 0 0 Q12774 ARHG5_HUMAN Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) ARHGEF5 TIM Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular signal transduction [GO:0035556]; myeloid dendritic cell chemotaxis [GO:0002408]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein import [GO:1904591]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] anchoring junction [GO:0070161]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102] GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] EKKPKEVMGGFSR;ITRLKLLLQNILK;LSLKSFLILPFQRITR;RELQVPEENRADSQDEK;RTTPQQGASGPGR 5 4.3 0.97627 -1.4695 0 0 3.55545 5.6163 3.06102 0 0 5.40807 0 0 3.79077 11.4655 Q12788 TBL3_HUMAN Transducin beta-like protein 3 (WD repeat-containing protein SAZD) TBL3 SAZD Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] DPEACEKLEATMLR 1 1.7 0.98083 -1.6051 0 0 0 0 0 0 0 0 0 0 9.94408 0 Q12789 TF3C1_HUMAN General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) GTF3C1 Homo sapiens (Human) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription [GO:0009304]; tRNA transcription by RNA polymerase III [GO:0042797] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] ASANLRPKTQPHHSTPTK;EELGLCERTFKR;GFMEDEGR;ISNSSTANR;LQEIHPECGPCK;NITNDIRTKSLQPR;VAMNVGK;VAMNVGKLEAR 8 4 0.97314 -2.9144 0 0 0 10.7018 10.1402 5.47664 0 0 11.0897 9.84892 10.6946 11.7302 Q12791 KCMA1_HUMAN "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)" KCNMA1 KCNMA SLO Homo sapiens (Human) intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249] RACCFDCGR 1 0.7 0.74893 0.083315 0 0 5.18428 0 0 0 0 0 0 0 0 0 Q12791 KCMA1_HUMAN "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)" KCNMA1 KCNMA SLO Homo sapiens (Human) intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249] ATHFGSPEMPPAAR;GASSLALEVARCR 2 16.1 0.96464 -1.2208 0 0 0 0 6.68776 0 0 0 0 10.5771 0 0 Q12792 TWF1_HUMAN Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) TWF1 PTK9 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of neuron projection development [GO:0010976]; regulation of lamellipodium assembly [GO:0010591]; sequestering of actin monomers [GO:0042989] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" EAFQALEK 1 2.3 0.29277 0.25302 0 12.2654 0 0 0 0 11.8005 10.1707 9.97628 0 10.4201 10.2677 Q12796 PNRC1_HUMAN Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) PNRC1 PROL2 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleus [GO:0005634]; P-body [GO:0000932] ENYAGAK;LAPLGFSSR;TVVSVPQR 3 7.3 0.98067 -1.7799 7.83662 8.00669 0 0 0 0 0 0 0 0 0 0 Q12797 ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) ASPH BAH Homo sapiens (Human) "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]" calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] DEGLAVMDK 1 1.2 0.90925 -0.31495 0 0 0 0 0 0 9.23304 0 0 0 0 0 Q12797 ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) ASPH BAH Homo sapiens (Human) "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]" calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] MASRDKDDR 1 4 0.82523 -0.021277 7.94128 0 0 0 0 0 0 0 0 0 0 0 Q12800 TFCP2_HUMAN Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) TFCP2 LSF SEF Homo sapiens (Human) mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]" NRFSTFTR 1 1.6 0.98021 -1.5553 0 0 0 0 0 10.1147 0 0 0 0 0 0 Q12802 AKP13_HUMAN A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of Rho protein signal transduction [GO:0035023]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267] EVMRAPPSGR;EVQAVLLTDILVFLQEKDQK;LGLLRLTWFLLQKPGGR;LSQRQTER;NAAGRLK;QQAQYLEEKR 6 2.6 0.97485 -3.7293 10.1753 0 0 8.27589 0 9.96593 0 0 0 0 5.87549 0 Q12805 FBLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) EFEMP1 FBLN3 FBNL Homo sapiens (Human) camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of chondrocyte differentiation [GO:0032331]; peptidyl-tyrosine phosphorylation [GO:0018108]; post-embryonic eye morphogenesis [GO:0048050]; regulation of DNA-templated transcription [GO:0006355]; visual perception [GO:0007601] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083] TCQDINECETTNECR 1 3 0.78242 0.021912 0 0 0 4.54733 0 0 0 0 0 0 0 0 Q12809 KCNH2_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 ERG ERG1 HERG Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cellular response to xenobiotic stimulus [GO:0071466]; membrane depolarization during action potential [GO:0086010]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005] cell surface [GO:0009986]; inward rectifier potassium channel complex [GO:1902937]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] MAAPAGK;SNGDVRALTYCDLHKIHR 2 3.1 0.95754 -1.0207 8.07017 0 0 0 3.84579 0 11.2407 9.79403 0 4.62029 0 0 Q12816 TROP_HUMAN Trophinin (MAGE-D3 antigen) TRO KIAA1114 MAGED3 Homo sapiens (Human) embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634]; plasma membrane [GO:0005886] AAQGSQSPTGHEGGTIQLK;VPNSRPPEYEFFWGLRSYHETSKMK;VQKKDPK 3 3.6 0.41451 0.20147 0 0 0 9.20704 0 0 0 0 0 8.14766 0 0 Q12824 SNF5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) SMARCB1 BAF47 INI1 SNF5L1 Homo sapiens (Human) blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; DNA integration [GO:0015074]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; germ cell nucleus [GO:0043073]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713] NTGDADQWCPLLETLTDAEMEK;QQIESYPTDSILEDQSDQRVIIK 2 11.7 0.71779 0.13588 0 0 0 0 9.37543 0 0 0 0 0 0 0 Q12829 RB40B_HUMAN Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar) RAB40B SEC4L Homo sapiens (Human) cellular detoxification [GO:1990748]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] endosome [GO:0005768]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924] IVLLRHGMDRLWRPSK;VLSLQDLCCR 2 9.4 0.97789 -1.5128 0 0 0 11.413 0 0 0 0 0 0 0 0 Q12830 BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) BPTF FAC1 FALZ Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cellular response to nerve growth factor stimulus [GO:1990090]; chromatin remodeling [GO:0006338]; embryonic placenta development [GO:0001892]; endoderm development [GO:0007492]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] ATPase complex [GO:1904949]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] DSDDKTPDDDPEQGKSEEPTEVGDK;DYWEAELCKILEEMREEIHR;NFGTVLR;NNENRESEKK;TVITEVTTMTSTVATESK;VLDDVSIRSPETK;VQRRYYEK 7 3.3 0.97956 -1.8868 10.7156 0 0 0 6.67158 9.37899 0 14.872 0 15.0759 14.917 0 Q12834 CDC20_HUMAN Cell division cycle protein 20 homolog (p55CDC) CDC20 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of cell cycle [GO:0044784]; metaphase/anaphase transition of meiosis I [GO:1990949]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; nervous system development [GO:0007399]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LWRCFELDPAR 1 2.2 0.91304 -0.38342 0 11.2003 0 0 0 0 0 0 0 0 0 0 Q12836 ZP4_HUMAN Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4] ZP4 ZPB Homo sapiens (Human) acrosomal vesicle exocytosis [GO:0060478]; binding of sperm to zona pellucida [GO:0007339]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of humoral immune response [GO:0002922]; positive regulation of T cell proliferation [GO:0042102]; prevention of polyspermy [GO:0060468] collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] acrosin binding [GO:0032190]; identical protein binding [GO:0042802]; structural constituent of egg coat [GO:0035804] EGHFSIAVSR;GCPYIGDNYQTQLIPVQK;LRVPVDSKVLWVAGLSGTLILGALLVSYLAVK 3 11.1 0.83675 -0.034893 0 0 0 4.76256 0 0 0 6.70224 9.20882 0 0 6.5284 Q12840 KIF5A_HUMAN Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) KIF5A NKHC1 Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; synaptic vesicle transport [GO:0048489]; vesicle-mediated transport [GO:0016192] axon cytoplasm [GO:1904115]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] DNADLRCELPK;LEAELSRWR;QLVRDNADLRCELPK;TGAEGAVLDEAK;TIDELKDLNQK;VLCRFRPLNQAEILR;YQQEVDR 7 6.7 0.97534 -3.3557 0 0 0 0 0 0 0 10.8497 7.95704 0 0 13.1579 Q12841 FSTL1_HUMAN Follistatin-related protein 1 (Follistatin-like protein 1) FSTL1 FRP Homo sapiens (Human) cell differentiation [GO:0030154]; endothelial cell differentiation [GO:0045446]; endothelial cell migration [GO:0043542]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of apoptotic process [GO:0043066]; regulation of BMP signaling pathway [GO:0030510] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] RWLALALALVAVAWVR;SVSPSASPVVCYQSNRDELRR;YVQELQKHQETAEK 3 16.6 0.90843 -0.27772 0 4.70072 0 0 6.45204 0 0 0 0 7.90292 0 0 Q12849 GRSF1_HUMAN G-rich sequence factor 1 (GRSF-1) GRSF1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; mitochondrial RNA catabolic process [GO:0000957]; morphogenesis of embryonic epithelium [GO:0016331]; mRNA processing [GO:0006397]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; regulation of RNA splicing [GO:0043484]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] G-quadruplex RNA binding [GO:0002151]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GLQTGPVPPGR;HREEIGNR 2 4 0.91198 -0.32294 0 0 0 0 7.26303 0 0 0 10.3605 0 0 0 Q12851 M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) MAP4K2 GCK RAB8IP Homo sapiens (Human) immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; vesicle targeting [GO:0006903] basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FGAPRRK;SSFQPPKLR 2 2 0.96435 -1.1959 0 0 0 0 0 0 0 0 0 0 13.4074 0 Q12852 M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) MAP3K12 ZPK Homo sapiens (Human) intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of motor neuron apoptotic process [GO:2000672]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein kinase activity [GO:0045860]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674] LEEELVMRR 1 1 0.73057 0.11464 0 0 0 0 0 0 0 0 9.92844 0 0 0 Q12857 NFIA_HUMAN Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) NFIA KIAA1439 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell morphogenesis [GO:0000902]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; limb morphogenesis [GO:0035108]; neural precursor cell proliferation [GO:0061351]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; synapse maturation [GO:0060074]; ureter development [GO:0072189]; viral genome replication [GO:0019079] cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KPPCCVLSNPDQK 1 2.6 0.93338 -0.50849 0 0 9.74302 0 0 0 0 0 0 0 0 0 Q12860 CNTN1_HUMAN Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3) CNTN1 Homo sapiens (Human) axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765] axon [GO:0030424]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552] carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632] EGKGMVLLCDPPYHFPDDLSYR;IVESYQIRYWAAHDK;MKMWLLVSHLVIISITTCLAEFTWYR;WLLNEFPVFITMDKR 4 7.7 0.74551 0.095787 0 0 0 0 0 9.27524 0 0 9.90799 0 9.55011 9.07398 Q12864 CAD17_HUMAN Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin) CDH17 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; oligopeptide transmembrane transport [GO:0035672]; oligopeptide transport [GO:0006857]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427] AENPEPLVFGVK;EGSQELNPAK;LSTRHTEFEEREYVVLIR 3 4.8 0.91616 -0.33361 0 0 0 6.68734 9.85087 9.93314 0 0 0 0 0 0 Q12866 MERTK_HUMAN Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) MERTK MER Homo sapiens (Human) cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; natural killer cell differentiation [GO:0001779]; negative regulation of cytokine production [GO:0001818]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of lymphocyte activation [GO:0051250]; nervous system development [GO:0007399]; neutrophil clearance [GO:0097350]; phagocytosis [GO:0006909]; platelet activation [GO:0030168]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; retina development in camera-type eye [GO:0060041]; secretion by cell [GO:0032940]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; vagina development [GO:0060068] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] FNCSISVPNIYQDTTISWWK;GPAPLPLLLGLFLPALWRRAITEAR;ISHVWQSAGISK;TDPLDRPTFSVLR 4 7 0.98058 -1.7949 0 0 7.62921 9.01265 0 0 0 0 0 8.25456 0 0 Q12872 SFSWA_HUMAN "Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)" SFSWAP SFRS8 SWAP Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]" nucleus [GO:0005634] RNA binding [GO:0003723] AGSGGKK;AKHSLPSAYR;FETSVRAKNDQR;ITQDLMAK;MHAIIER;VTASPGTLR;YGASGGR 7 6 0.97679 -4.7818 0 12.4911 0 7.89536 0 0 8.67193 0 8.69836 10.9407 0 9.43937 Q12873 CHD3_HUMAN Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) CHD3 Homo sapiens (Human) centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; PML body [GO:0016605] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] EEEDDHMEYCR;EEEDDHMEYCRVCK;ELIMGEDPAQPR;IINHSVDKKGNYHYLVK;IPPIAARLQMSER;VQEFEHINGR;WVGLSYWHCSWAK 7 4 0.96491 -1.1632 7.23601 0 0 0 0 0 9.34879 4.47742 9.23795 6.24092 5.01774 10.7819 Q12874 SF3A3_HUMAN Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) SF3A3 SAP61 Homo sapiens (Human) "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ETILEQQRRYHEEK;METILEQQR 2 3 0.0086393 1.04 0 0 11.1067 0 0 0 0 0 0 9.89376 0 0 Q12879 NMDE1_HUMAN "Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)" GRIN2A NMDAR2A Homo sapiens (Human) "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; chemical synaptic transmission [GO:0007268]; directional locomotion [GO:0033058]; dopamine metabolic process [GO:0042417]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein catabolic process [GO:0030163]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; serotonin metabolic process [GO:0042428]; sleep [GO:0030431]; sodium ion transmembrane transport [GO:0035725]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]" cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021] amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] ELDLSRPSRSISLK;SPFKCDACLR 2 1.6 0.97865 -1.9676 0 0 0 0 0 0 0 0 9.49129 0 0 9.7937 Q12882 DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) DPYD Homo sapiens (Human) beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212] cytoplasm [GO:0005737]; cytosol [GO:0005829] "4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058]" CEFLPFLSPRK;EEKCEFLPFLSPR;IAELMDK;LTPNVTDIVSIAR;TQTHATLCSTSAK;TTPYEPK 6 5.3 0.97306 -2.4966 0 0 0 9.53962 5.56715 0 0 10.2803 0 0 8.29678 10.3401 Q12884 SEPR_HUMAN "Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]" FAP Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; melanocyte apoptotic process [GO:1902362]; melanocyte proliferation [GO:0097325]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of extracellular matrix organization [GO:1903054]; positive regulation of execution phase of apoptosis [GO:1900119]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of fibrinolysis [GO:0051917] apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; peptidase complex [GO:1905368]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] dipeptidyl-peptidase activity [GO:0008239]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] FMGLPTK;KCVTCHLRK;TINIPYPK 3 3.2 0.97781 -2.1607 0 0 0 10.2382 0 0 0 0 0 0 6.73145 0 Q12888 TP53B_HUMAN TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) TP53BP1 Homo sapiens (Human) cellular response to X-ray [GO:0071481]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; protein localization to site of double-strand break [GO:1990166] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric DNA binding [GO:0042162]; transcription coregulator activity [GO:0003712]; ubiquitin-modified histone reader activity [GO:0061649] ASVAAMEAK;EVRTLVTR;GEELEQKEK;KITESPR;KNGSTAVAESVASPQKTMSVLSCICEAR 5 3.1 0.98025 -1.8653 0 6.59174 11.9179 0 10.0743 0 0 0 0 0 7.56209 0 Q12889 OVGP1_HUMAN Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin) OVGP1 MUC9 OGP Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; female pregnancy [GO:0007565]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; single fertilization [GO:0007338] cytosol [GO:0005829]; egg coat [GO:0035805]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; perivitelline space [GO:0098595]; transport vesicle [GO:0030133] chitin binding [GO:0008061]; chitinase activity [GO:0004568] EKVTVPSR;GTTVTPTK;LLKASKNGLQAR;LLLWVGLVLVLK;WKLLLWVGLVLVLK 5 6.2 0.9804 -1.7194 0 3.50208 0 0 0 0 0 0 10.2142 13.0748 12.9004 4.95555 Q12893 TM115_HUMAN Transmembrane protein 115 (Placental protein 6) (Protein PL6) TMEM115 PL6 LUCA11.2 Homo sapiens (Human) "negative regulation of cell population proliferation [GO:0008285]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] identical protein binding [GO:0042802] VKICQKTVK;VPQVRVSVMPMLLLALLLLLR;VSVMPMLLLALLLLLR 3 8.5 0.98075 -1.6464 0 0 0 0 0 0 0 6.68664 0 9.66745 4.72203 0 Q12894 IFRD2_HUMAN Interferon-related developmental regulator 2 (Protein SKMC15) IFRD2 Homo sapiens (Human) negative regulation of translation [GO:0017148] nucleus [GO:0005634] ribosome binding [GO:0043022]; translation repressor activity [GO:0030371] GEEQALAAAVLGLLCVQLGPGPK 1 5.2 0.70068 0.16126 0 0 0 0 0 0 0 0 0 4.49096 0 0 Q12899 TRI26_HUMAN Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173) TRIM26 RNF95 ZNF173 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GVGELAR;LVPFLWLKWPGTRLLLRP 2 4.6 0.52156 0.18712 0 6.95768 0 14.0696 14.2208 0 0 0 0 0 14.7023 15.5483 Q12904 AIMP1_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] AIMP1 EMAP2 SCYE1 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of glucagon secretion [GO:0070094]; translation [GO:0006412] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634] cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] GVCRAQTMSNSGIK 1 4.5 0.88213 -0.18002 6.75221 0 0 0 0 0 0 0 0 0 0 0 Q12905 ILF2_HUMAN Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) ILF2 NF45 PRO3063 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723] AQDPSEVLTMLTNETGFEISSSDATVK;ILITTVPPNLR;ILPTLEAVAALGNK;NQDLAPNSAEQASILSLVTK;VKPAPDETSFSEALLK 5 22.6 0 16.591 11.1123 10.2945 0 10.1647 9.9331 9.34882 14.3224 14.0131 14.3898 8.75669 9.91376 0 Q12906 ILF3_HUMAN Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) ILF3 DRBF MPHOSPH4 NF90 Homo sapiens (Human) defense response to virus [GO:0051607]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; spliceosome-depend formation of circular RNA [GO:0160091] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; virus receptor activity [GO:0001618] AVSDWIDEQEK;EDITQSAQHALR;LFPDTPLALDANK;NPVMELNEK;VLQDMGLPTGAEGR;VLRDLCTRVPTWGPLR;VPTWGPLR 7 8.4 0 2.9743 0 10.4272 9.74589 0 0 0 12.1543 12.5852 11.5962 10.5518 11.0225 0 Q12907 LMAN2_HUMAN Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) LMAN2 C5orf8 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872] LTPDERSK;LTVMTDLEDK;LVPGPVFGSK 3 7.9 0.93679 -0.54371 0 12.9881 13.019 0 9.432 10.5033 0 0 0 0 0 0 Q12912 IRAG2_HUMAN "Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]" IRAG2 JAW1 LRMP Homo sapiens (Human) immune system process [GO:0002376]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; chromosome [GO:0005694]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] microtubule binding [GO:0008017] LSLGFKCDWFTLEK;SFNPLEDDDDCQIKKR;TILNLEAK;VTIASLPR 4 8.3 0.95166 -0.67036 15.2155 15.9647 0 12.6746 13.7044 13.9167 0 10.118 14.4761 15.9083 15.7907 0 Q12913 PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) PTPRJ DEP1 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; B cell differentiation [GO:0030183]; blood coagulation [GO:0007596]; contact inhibition [GO:0060242]; cytokine-mediated signaling pathway [GO:0019221]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion [GO:0045785]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion [GO:0030155]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579] "beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; mitogen-activated protein kinase binding [GO:0051019]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" KDFIATQGPLPNTLK;LPPRSPGLRWALPLLLLLLR;NVYAIIMLTKCVEQGR;VIKVITEPIPVSDLRVALTGVR;VSDNESSSNYTYK;YLVRDYMK 6 7 0.94151 -0.603 0 0 5.91377 0 7.86499 0 0 4.87725 0 0 10.2989 0 Q12923 PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) cellular response to toxic substance [GO:0097237]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" EAMNVEEPVRR;LKPGDRLIK;LTEYGVHFHRVHPEK;NDLPVVPSSK;QENWTPLK;SLNLQAESVR;VAPEGWKEEPK;VLPSGKYTGANLK;YTGANLK 9 3.5 0.9785 -6.6996 11.4764 0 0 6.95652 9.05126 9.77307 0 0 12.8191 9.05921 6.96475 15.0745 Q12929 EPS8_HUMAN Epidermal growth factor receptor kinase substrate 8 EPS8 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; cellular response to leukemia inhibitory factor [GO:1990830]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] brush border [GO:0005903]; cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] actin binding [GO:0003779]; small GTPase binding [GO:0031267] FKHGFNLLAKLK;ISAAASDSGVESFDEGSSH 2 3.8 0.9369 -0.52663 0 0 0 0 0 0 0 0 0 0 0 8.21965 Q12931 TRAP1_HUMAN "Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)" TRAP1 HSP75 HSPC5 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; protein folding [GO:0006457]; translational attenuation [GO:0009386] cell periphery [GO:0071944]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tumor necrosis factor receptor binding [GO:0005164]; unfolded protein binding [GO:0051082] DTEVLFCFEQFDELTLLHLR;ELISNASDALEK;ELLQESALIR;NIYYLCAPNR;RLRPLLR;VEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVR 6 13.2 0.0045045 1.1982 11.7367 13.364 13.1804 9.93952 0 10.5236 0 0 0 0 3.52882 0 Q12933 TRAF2_HUMAN TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) TRAF2 TRAP3 Homo sapiens (Human) CD27 signaling pathway [GO:0160162]; CD40 signaling pathway [GO:0023035]; cellular response to nitric oxide [GO:0071732]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mRNA stabilization [GO:0048255]; negative regulation of glial cell apoptotic process [GO:0034351]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of immunoglobulin production [GO:0002637]; regulation of JNK cascade [GO:0046328]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; signal transduction involved in regulation of gene expression [GO:0023019]; T cell activation [GO:0042110]; TORC1 complex assembly [GO:1905669]; TORC2 complex disassembly [GO:1905670]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; TRAF2-GSTP1 complex [GO:0097057]; tumor necrosis factor receptor superfamily complex [GO:0002947]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506] CD40 receptor binding [GO:0005174]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] HCRAPCCGADVKFQDHVK;IEALSSKVQQLERSIGLK;VTLMLLDQNNR;YLCSACR 4 11.3 0.96669 -1.2807 0 0 0 0 7.95919 0 0 10.8497 11.0119 8.72707 12.3264 0 Q12934 BFSP1_HUMAN Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment] BFSP1 Homo sapiens (Human) cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886] structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] KEIEETER;SPKEPETPTELYTK 2 3.3 0.92065 -0.43751 0 0 4.36611 0 0 0 8.87191 9.22629 0 0 5.29009 0 Q12951 FOXI1_HUMAN Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3) FOXI1 FKHL10 FREAC6 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; embryo development ending in birth or egg hatching [GO:0009792]; inner ear morphogenesis [GO:0042472]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" DEDDPGK;HNLSLNDCFK 2 4.5 0.95472 -0.95788 0 0 0 4.36982 0 0 0 0 0 0 0 0 Q12952 FOXL1_HUMAN Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) FOXL1 FKHL11 FREAC7 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" VTLNGIYQFIMDR 1 3.8 0.78664 0.017861 11.6734 0 0 0 0 0 0 11.2674 0 0 0 0 Q12955 ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to axon [GO:0099612]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] axon initial segment [GO:0043194]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; costamere [GO:0043034]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; lysosome [GO:0005764]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; T-tubule [GO:0030315]; Z disc [GO:0030018] cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325] AASEKDYNLTK;ASAEKASNQK;ASSEEDDHNR;DVCVDNK;ELAGLFEHK;ELNFSVDEINQIR;GGSMRGSRHHGMR;IDAKTRDGLTPLHCGAR;IISQECK;KIISQECKTVQETR;SLEETSK;SSLFLAPSALK;TEKLNDELQSPEK;YLGPQDLK 14 3.3 0.97831 -7.5813 11.386 11.3224 0 0 10.5952 8.32638 10.5743 9.89235 0 11.0713 12.2217 10.6899 Q12955 ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to axon [GO:0099612]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] axon initial segment [GO:0043194]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; costamere [GO:0043034]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; lysosome [GO:0005764]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; T-tubule [GO:0030315]; Z disc [GO:0030018] cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325] ELNFSVDEINQIR;GGSMRGSRHHGMR;LANPPPHGER;RYSYLTEPGMTSCTVK;SLEETSK;YLGPQDLK 6 4.6 0.81167 -0.01211 0 0 0 0 0 0 0 0 8.90641 0 7.79928 0 Q12962 TAF10_HUMAN Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) TAF10 TAF2A TAF2H TAFII30 Homo sapiens (Human) allantois development [GO:1905069]; apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; embryonic placenta development [GO:0001892]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251] AGEPAERR 1 3.7 0.73153 0.11366 0 0 0 0 0 8.11769 0 0 0 0 0 0 Q12965 MYO1E_HUMAN Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) MYO1E MYO1C Homo sapiens (Human) actin filament organization [GO:0007015]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; glomerulus development [GO:0032835]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol binding [GO:0035091] IDFADTVTKYDR;KPRDWEESRVK;QANDLVSTLMKCTPHYIR;VSGGGTK;VSYDMDGFCERNR 5 5.5 0.97472 -2.3821 7.74987 0 11.0199 10.3182 10.9769 0 0 0 0 12.1655 0 0 Q12967 GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) RALGDS KIAA1308 RGF Homo sapiens (Human) Ras protein signal transduction [GO:0007265] brush border [GO:0005903]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085] KVVPYHCLGSIWSQR;SVWDAVR 2 2.4 0.91571 -0.37209 0 0 0 0 0 0 0 0 10.5507 8.28327 0 0 Q12967 GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) RALGDS KIAA1308 RGF Homo sapiens (Human) Ras protein signal transduction [GO:0007265] brush border [GO:0005903]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085] EAGQVCARPAVPRGRK;KVVPYHCLGSIWSQR 2 3.4 0.26048 0.26955 0 5.29987 0 0 0 0 0 8.83744 0 0 0 0 Q12974 TP4A2_HUMAN Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) PTP4A2 PRL2 PTPCAAX2 BM-008 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" GAFNSKQLLYLEKYRPK;RGAFNSK 2 10.8 0.89806 -0.23326 0 0 0 0 0 9.94009 0 9.60275 0 5.4004 0 0 Q12979 ABR_HUMAN Active breakpoint cluster region-related protein ABR Homo sapiens (Human) activation of GTPase activity [GO:0090630]; modulation of chemical synaptic transmission [GO:0050804]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EPLSHRGLPR;TVHNIPVTSNK 2 2.4 0.95509 -0.78806 0 0 0 0 0 0 9.5264 0 0 0 0 0 Q12980 NPRL3_HUMAN GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) NPRL3 C16orf35 CGTHBA MARE Homo sapiens (Human) aorta morphogenesis [GO:0035909]; cardiac muscle tissue development [GO:0048738]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; roof of mouth development [GO:0060021]; TORC1 signaling [GO:0038202]; ventricular septum development [GO:0003281] GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765] GTPase activator activity [GO:0005096] FVGHPTLLQHALGQISKTDPSPKR;MFARLLHYFRGR;RCQYLTREAK;YAASNTGDHADEQDGDSR 4 11.2 0.94417 -0.63174 0 0 10.9121 0 8.38193 0 9.14909 0 0 0 0 0 Q12981 SEC20_HUMAN Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) BNIP1 NIP1 SEC20L TRG8 Homo sapiens (Human) "apoptotic process [GO:0006915]; apoptotic process in response to mitochondrial fragmentation [GO:0140208]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; SNARE complex [GO:0031201] calcium-induced calcium release activity [GO:0048763]; SNAP receptor activity [GO:0005484] ELTDKLLIFLALALFLATVLYIVK;IAIDNLEK;IQDLEQLAK;LLIFLALALFLATVLYIVK 4 18 0.95714 -0.8485 0 0 12.3365 0 0 0 0 0 7.58105 0 4.38736 6.63366 Q12982 BNIP2_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 BNIP2 NIP2 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; response to oxygen-glucose deprivation [GO:0090649] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] WFSIYDQRPSWYRTKK 1 4.3 0.45214 0.19148 0 0 0 0 0 9.6752 0 0 0 0 0 0 Q12986 NFX1_HUMAN "Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)" NFX1 NFX2 Homo sapiens (Human) inflammatory response [GO:0006954]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]" CGNHTCSQVCHPQPCQQCPR;DDLNERPAKSTCDSENLAVINK;ELPCTSLK;GVLDGYGAR;HKCNEICCVDKEHK;NPEWSRNEIPHSCGEVCRK;TCECGRTRHTVR;VDQEKCTVRR 8 10.2 0.9741 -2.4152 0 0 8.51412 0 11.3403 0 0 10.3879 0 8.91361 8.41469 6.03014 Q12988 HSPB3_HUMAN Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) HSPB3 HSP27 HSPL27 Homo sapiens (Human) response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] YQEEFEAR 1 5.3 0.87838 -0.14057 0 0 0 0 0 0 0 0 0 0 0 6.50817 Q12996 CSTF3_HUMAN Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) CSTF3 Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; RNA 3'-end processing [GO:0031123]" mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] ARKTYER;FLAFESNIGDLASILKVEKR 2 3.8 0.97239 -1.3589 0 0 0 0 0 0 0 9.5206 0 0 0 0 Q13002 GRIK2_HUMAN "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) "behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; detection of cold stimulus involved in thermoception [GO:0120169]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; positive regulation of synaptic transmission [GO:0050806]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]" glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; mossy fiber rosette [GO:0097471]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] FAVNTINRNR 1 1.1 0.97928 -1.5335 0 0 0 0 0 0 0 11.3168 0 0 0 0 Q13003 GRIK3_HUMAN "Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)" GRIK3 GLUR7 Homo sapiens (Human) "G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]" axon [GO:0030424]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IEYGAVKDGATMTFFK;RLRSLVWEYWAGLLVCAFWIPDSR;SLIVTTVLEEPFVMFRKSDR;VGVWSPADGLNITEVAKGR 4 8.6 0.95474 -0.94783 0 0 11.0561 0 9.67439 7.11364 0 0 0 0 0 7.68011 Q13007 IL24_HUMAN Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) IL24 MDA7 ST16 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125] ALGEVDILLTWMQK 1 6.8 0.68282 0.16503 0 0 0 0 0 0 9.80382 0 0 0 0 0 Q13009 TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) TIAM1 Homo sapiens (Human) "activation of GTPase activity [GO:0090630]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; neuron projection extension [GO:1990138]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to cocaine [GO:0042220]; small GTPase-mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" axonal growth cone [GO:0044295]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; receptor tyrosine kinase binding [GO:0030971] AGDEILEINNR;DCEEARGMETR;EDTLRLLK;GASVDRDLQER;LVPDLEKLEK;MGEMQLSSVTDSK;VICELLETER;VTQSIHIEK 8 5.2 0.97676 -4.8955 0 11.3245 10.7101 0 11.4677 9.06167 0 0 0 9.7846 0 0 Q13011 ECH1_HUMAN "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)" ECH1 Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity [GO:0051750]" AVVISGAGK;DIITRYQETFNVIER;SVQATTENK 3 10.1 0.020833 0.64381 0 0 9.03862 0 0 0 0 0 0 12.1705 10.3288 0 Q13015 AF1Q_HUMAN Protein AF1q MLLT11 AF1Q Homo sapiens (Human) extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] centrosome [GO:0005813]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] NPEGDGLLEYSTFNFWR 1 18.9 0.78191 0.022128 0 0 0 0 0 0 0 0 0 0 5.73779 0 Q13017 RHG05_HUMAN Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) ARHGAP5 RHOGAP5 Homo sapiens (Human) cell adhesion [GO:0007155]; epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169] ARNTFSKHIEQLK;FVNNLFVQLSKSKKPVIIAATK;HQGQQLANK;KARNTFSK;RIQITILSYHSSIGVR 5 4.1 0.97231 -2.8211 0 8.54554 0 0 10.6634 7.82966 10.2 0 0 0 8.35447 0 Q13017 RHG05_HUMAN Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) ARHGAP5 RHOGAP5 Homo sapiens (Human) cell adhesion [GO:0007155]; epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169] PLQDLVTAEKPIPLFVEK 1 7.5 0.7842 0.026013 0 0 0 0 0 0 0 0 0 0 0 7.01402 Q13018 PLA2R_HUMAN Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] PLA2R1 CLEC13C Homo sapiens (Human) "negative regulation of arachidonate secretion [GO:1900139]; negative regulation of phospholipase A2 activity [GO:1900138]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of podocyte apoptotic process [GO:1904635]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; replicative senescence [GO:0090399]" cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] carbohydrate binding [GO:0030246]; phospholipase binding [GO:0043274]; signaling receptor activity [GO:0038023] IKALSKYGASWWIGLQEER;KCIQAGK;LLSPSLLLLLLLGAPR;NPLNAGSWEWSDR 4 3.8 0.94518 -0.65035 4.45884 0 0 0 9.32764 7.82005 0 0 0 0 0 0 Q13023 AKAP6_HUMAN A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) AKAP6 AKAP100 KIAA0311 Homo sapiens (Human) action potential [GO:0001508]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cAMP [GO:0071320]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell growth [GO:0030307]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting [GO:0006605]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] calcium channel complex [GO:0034704]; caveola [GO:0005901]; cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315] adenylate cyclase binding [GO:0008179]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein-membrane adaptor activity [GO:0043495]; transmembrane transporter binding [GO:0044325] ELKGWLR;GLFLKEETFKNDLK;LLSYSVNVIVDIHAVQLLWHQLRVSVLVLR;LNVDSHCALK 4 2.6 0.97992 -1.8298 0 0 13.0505 0 0 0 0 9.25682 10.8377 0 9.01795 0 Q13029 PRDM2_HUMAN PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) PRDM2 KMT8 RIZ Homo sapiens (Human) determination of adult lifespan [GO:0008340]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" HCSDSEGK;KPLSPPKKK;NACESSSHICPYCNR;RRTASPPALPK;SLHVRVQKSK 5 3.1 0.97473 -3.1184 0 0 3.46676 0 13.3536 8.28503 0 5.47444 5.40776 0 0 0 Q13029 PRDM2_HUMAN PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) PRDM2 KMT8 RIZ Homo sapiens (Human) determination of adult lifespan [GO:0008340]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" TSPGSIGRSKLQLQPSSR 1 8 0.95231 -0.74796 0 0 0 0 0 0 0 10.6833 0 0 0 0 Q13033 STRN3_HUMAN Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) STRN3 GS2NA SG2NA Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estradiol [GO:0032355] cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] GVKRANR 1 0.9 0.8291 -0.022988 0 0 8.42202 0 0 0 0 0 0 0 0 0 Q13042 CDC16_HUMAN Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) CDC16 ANAPC6 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654] CYDFDVHTMK;KYAEALDYHR;NIISPPWDFR;RLFEKYLK 4 6.1 0.97296 -1.3753 0 0 0 0 0 0 0 0 10.8292 0 0 10.3045 Q13043 STK4_HUMAN Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] STK4 KRS2 MST1 Homo sapiens (Human) "apoptotic process [GO:0006915]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte apoptotic process [GO:1903945]; positive regulation of hippo signaling [GO:0035332]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; primitive hemopoiesis [GO:0060215]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] EVDQDDEENSEEDEMDSGTMVR;IPQDGDYEFLKSWTVEDLQKR;YYGSYFK 3 10.3 0.52922 0.18665 0 0 9.56117 0 0 0 0 0 0 0 0 0 Q13043 STK4_HUMAN Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] STK4 KRS2 MST1 Homo sapiens (Human) "apoptotic process [GO:0006915]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte apoptotic process [GO:1903945]; positive regulation of hippo signaling [GO:0035332]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; primitive hemopoiesis [GO:0060215]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] DICIQNCQGNLLCR;EVDQDDEENSEEDEMDSGTMVR;YYGSYFK 3 9.3 0.9461 -0.65601 0 0 0 0 0 0 0 0 0 0 4.60745 9.28126 Q13045 FLII_HUMAN Protein flightless-1 homolog FLII FLIL Homo sapiens (Human) actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; myofibril assembly [GO:0030239]; sarcomere organization [GO:0045214] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell projection [GO:0042995]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" FYEADCYIVLK;GVDLSGNDFK;LSVEHKQRPK;MEATGVLPFVR 4 3.3 0.012371 0.88139 0 0 0 9.90387 0 8.79656 0 0 0 11.1253 0 0 Q13046 PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7) PSG7 Homo sapiens (Human) female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] ESSKSVTVR 1 2.1 0.90195 -0.26354 0 0 0 0 0 0 0 0 0 9.33483 0 0 Q13049 TRI32_HUMAN E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) TRIM32 HT2A Homo sapiens (Human) actin ubiquitination [GO:0007014]; autophagosome assembly [GO:0000045]; axon development [GO:0061564]; cellular response to amino acid starvation [GO:0034198]; cellular response to stress [GO:0033554]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of cilium assembly [GO:1902018]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome [GO:0005776]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863] identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ELMGELQR;LLHCGHTICRQCLEK;LWCFTVDRGSGVVK 3 5.7 0.95357 -0.7811 0 0 9.6074 0 0 0 0 0 0 0 11.3175 0 Q13057 COASY_HUMAN Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] COASY PSEC0106 Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937]; purine nucleoside bisphosphate biosynthetic process [GO:0034033]; purine ribonucleotide biosynthetic process [GO:0009152]; ribonucleoside bisphosphate biosynthetic process [GO:0034030] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595] LAREEMDRAVAEGK;YATSCYSCCPR 2 4.4 0.75688 0.073677 0 0 0 0 0 3.84046 0 0 0 0 0 9.66947 Q13061 TRDN_HUMAN Triadin TRDN Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; endoplasmic reticulum membrane organization [GO:0090158]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; intracellular calcium ion homeostasis [GO:0006874]; muscle contraction [GO:0006936]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to bacterium [GO:0009617] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] EPETKKDEK;IAAQAAAK;TAEKSEEK;VLKQVKAVTIEK 4 5.1 0.9785 -2.1159 0 11.5854 11.567 3.6234 9.78475 0 0 0 0 10.5826 0 0 Q13064 MKRN3_HUMAN E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) MKRN3 D15S9 RNF63 ZNF127 Homo sapiens (Human) protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] KELVVLRLASLLFK;MGEGNMLYK 2 4.5 0.91776 -0.40885 7.22313 0 0 3.08712 0 0 0 0 0 4.53767 0 0 Q13075 BIRC1_HUMAN Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nervous system development [GO:0007399]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of JNK cascade [GO:0046330]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981] basolateral plasma membrane [GO:0016323]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; IPAF inflammasome complex [GO:0072557] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283] ATQQKASDER;ELEEEEQKERAK;LSPKQYK;NLAEKEDNVKSYMDMQR 4 3.3 0.97315 -2.5784 5.86483 0 0 0 0 0 0 0 0 0 0 10.9673 Q13077 TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) TRAF1 EBI6 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] LYLNGDGTGK;VTFMLLDQNNR 2 5 0.9412 -0.60661 0 0 1.84996 0 0 0 0 0 0 9.44777 0 0 Q13084 RM28_HUMAN "Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Melanoma antigen p15) (Melanoma-associated antigen recognized by T-lymphocytes)" MRPL28 MAAT1 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EFYSEILDKK;TPTPVHYRPHGAK 2 9 0.87663 -0.12342 0 0 11.0111 8.23146 0 8.58868 0 11.1704 0 0 0 0 Q13085 ACACA_HUMAN Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) ACACA ACAC ACC1 ACCA Homo sapiens (Human) acetyl-CoA metabolic process [GO:0006084]; cellular response to prostaglandin E stimulus [GO:0071380]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]; lipid homeostasis [GO:0055088]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289]; tissue homeostasis [GO:0001894] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] AEGIPRIYVSANSGAR;GFSGGMK;IDTGWLDR;ILSTMDSPST;INIRLTPTGKAIPIR;IYVSANSGAR;LGTPELSTAER;MWWSTLMSILRAR;RLLLEDLVK 9 3.7 0.91708 -0.41254 8.48152 9.01187 11.946 0 0 8.74628 10.6551 7.81192 10.5612 0 0 0 Q13093 PAFA_HUMAN Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) PLA2G7 PAFAH Homo sapiens (Human) lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; peptide hormone processing [GO:0016486]; phosphatidylcholine catabolic process [GO:0034638]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor catabolic process [GO:0062234]; platelet activating factor metabolic process [GO:0046469]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte chemotaxis [GO:0090026] extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362] "1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; hydrolase activity, acting on ester bonds [GO:0016788]; phospholipid binding [GO:0005543]" IIGHMLK 1 1.6 0.93696 -0.55627 0 0 0 0 0 0 0 13.2486 0 0 0 0 Q13098 CSN1_HUMAN COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) GPS1 COPS1 CSN1 Homo sapiens (Human) JNK cascade [GO:0007254]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTPase inhibitor activity [GO:0005095] NVISSSSFKLFLELEPQVR 1 3.9 0.81282 -0.015865 0 0 0 0 0 0 0 0 0 0 10.3367 0 Q13099 IFT88_HUMAN Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) IFT88 TG737 TTC10 Homo sapiens (Human) cilium assembly [GO:0060271]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; response to silicon dioxide [GO:0034021] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; intraciliary transport particle B [GO:0030992]; manchette [GO:0002177]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212] kinesin binding [GO:0019894] DGSGGSRGK;EGSASGDSGQNYSASSK;GPASPLEAK;KFPENVECLR;NDHLRQMER 5 6.6 0.97343 -2.9026 0 0 10.1748 0 0 0 0 9.63517 3.30375 0 0 11.054 Q13103 SPP24_HUMAN Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2) SPP2 SPP24 Homo sapiens (Human) bone remodeling [GO:0046849]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089] endopeptidase inhibitor activity [GO:0004866] ISRMEKMTMMMK 1 5.7 0.95719 -1.0216 0 0 0 0 0 0 13.839 0 0 0 0 0 Q13105 ZBT17_HUMAN Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) ZBTB17 MIZ1 ZNF151 ZNF60 Homo sapiens (Human) ectoderm development [GO:0007398]; G1 to G0 transition [GO:0070314]; gastrulation with mouth forming second [GO:0001702]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator binding [GO:0001223]" FNQVGNLK;MRHLETHDTDKEHK;SLAEPATSPGGNAEALATEGGDKR;SYRLISLLNLHKK 4 7.3 0.98077 -1.6895 0 0 0 3.78429 0 0 0 0 7.72294 0 0 7.55428 Q13107 UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) USP4 UNP UNPH Homo sapiens (Human) negative regulation of protein ubiquitination [GO:0031397]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenosine receptor binding [GO:0031685]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LTLESLYQAVCDRISR 1 1.7 0.91679 -0.42575 0 0 7.65978 0 0 0 11.6004 0 0 0 0 0 Q13111 CAF1A_HUMAN Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) CHAF1A CAF CAF1P150 Homo sapiens (Human) DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334] CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] AEKAEITRFFQKPK;TAFHPDLCSQLDQLLQQQSGEFSFLKDLK;YLNRLNSCVKSTLSCFT 3 8 0.9564 -0.85073 0 10.0098 0 0 9.42738 0 7.37191 9.03807 0 0 0 0 Q13114 TRAF3_HUMAN TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) TRAF3 CAP-1 CRAF1 TRAFAMN Homo sapiens (Human) apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337] CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; serine/threonine protein kinase complex [GO:1902554]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] REILALQIYCRNESR;SAGTPVFVPEQGGYKEK;VIVDTSDLPDP;VSLLQNESVEK 4 9.5 0.95134 -0.70628 0 0 0 8.06566 0 5.7113 0 0 10.0794 0 0 11.4661 Q13115 DUS4_HUMAN Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 VH2 Homo sapiens (Human) dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" VTMEELR 1 1.8 0.93701 -0.52658 0 0 0 0 0 0 0 0 8.74069 0 0 0 Q13118 KLF10_HUMAN Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) KLF10 TIEG TIEG1 Homo sapiens (Human) bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; circadian rhythm [GO:0007623]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019] chromatin [GO:0000785]; nucleus [GO:0005634] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SPVSAPKLPK;SPVSAPKLPKAQATSVIR 2 3.8 0.90277 -0.26346 0 0 0 0 0 0 0 0 0 7.19495 0 0 Q13123 RED_HUMAN Protein Red (Cytokine IK) (IK factor) (Protein RER) IK RED RER Homo sapiens (Human) "mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]" chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005] identical protein binding [GO:0042802] AELDRQWK;KMEADGVEVK;LGRNVYR 3 4.5 0.97385 -2.4201 0 8.52305 0 0 0 0 0 0 0 0 0 0 Q13126 MTAP_HUMAN S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) MTAP MSAP Homo sapiens (Human) L-methionine salvage from methylthioadenosine [GO:0019509]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; purine ribonucleoside salvage [GO:0006166]; response to testosterone [GO:0033574] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] "1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]" QHTIMPSK 1 2.8 0.91497 -0.39033 0 0 10.4564 0 0 0 0 8.08905 0 0 0 0 Q13127 REST_HUMAN RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) REST NRSF XBR Homo sapiens (Human) "auditory receptor cell stereocilium organization [GO:0060088]; cardiac muscle cell myoblast differentiation [GO:0060379]; cellular response to electrical stimulus [GO:0071257]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to stress [GO:0033554]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; modification of synaptic structure [GO:0099563]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of amniotic stem cell differentiation [GO:2000798]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of dense core granule biogenesis [GO:2000706]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of programmed cell death [GO:0043068]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; somatic stem cell population maintenance [GO:0035019]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" ARKEQVLIEVGLVPVK;EADLPDNITNEK;GKDYSKHLNR 3 3.5 0.87793 -0.13799 8.21641 0 0 0 0 0 0 7.99486 7.96573 0 0 0 Q13129 RLF_HUMAN Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) RLF Homo sapiens (Human) negative regulation of heterochromatin formation [GO:0031452]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DLTDQHKEKR;FDEENAPVPNSLR;KVHPYHFKPK;LIAQEGPSFLQMR;QLHYLRPVVVLERSK;TIACLLPEDLEVRR;TVHQYNKEQLCLEKDK 7 4.8 0.93016 -0.46901 0 0 0 10.8112 10.23 0 0 10.7152 10.2325 0 9.03551 8.53691 Q13133 NR1H3_HUMAN Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) NR1H3 LXRA Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of circadian rhythm [GO:0042752]; response to progesterone [GO:0032570]; sterol homeostasis [GO:0055092]; triglyceride homeostasis [GO:0070328] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "cholesterol binding [GO:0015485]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" AEPPSEPTEIRPQKRK;EDQIALLKTSAIEVMLLETSRR;VTPWPMAPDPHSR 3 11.4 0.95504 -0.79557 0 0 0 0 0 6.64351 0 0 8.94307 0 0 9.29893 Q13133 NR1H3_HUMAN Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) NR1H3 LXRA Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of circadian rhythm [GO:0042752]; response to progesterone [GO:0032570]; sterol homeostasis [GO:0055092]; triglyceride homeostasis [GO:0070328] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "cholesterol binding [GO:0015485]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" AEPPSEPTEIRPQKRK;VTVMLLETSR 2 6.7 0.88826 -0.18368 0 0 0 0 0 0 0 0 0 0 9.34092 0 Q13136 LIPA1_HUMAN Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; cortical microtubule organization [GO:0043622]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stress fiber assembly [GO:0051497]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]; synapse organization [GO:0050808] axon [GO:0030424]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; spine apparatus [GO:0097444] AERNNTRLLLEHLECLVSR;ELNVCREQLLEREEEIAELK;EVDRLGVMTLLPPSR;ITTLEKR;LGGQAEK;LGGQAEKNRK;LLSESNER;LSDTVDK;NNTRLLLEHLECLVSR;NRQLQER 10 7.7 0.97491 -3.2252 0 12.9611 13.6131 7.0167 8.5041 0 11.4429 12.7221 8.9059 10.8168 8.98641 10.8456 Q13137 CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) CALCOCO2 NDP52 Homo sapiens (Human) positive regulation of autophagosome maturation [GO:1901098]; response to type II interferon [GO:0034341]; viral process [GO:0016032]; xenophagy [GO:0098792] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605] metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] CFQDKLEQELLK;KENDHLFLSLTEQRK;KQQELMDENFDLSKR;LEQTVEQMK 4 10.9 0.96514 -1.1357 0 0 11.2747 6.49967 0 0 9.54917 9.63019 0 0 8.50839 8.19962 Q13144 EI2BE_HUMAN Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) EIF2B5 EIF2BE Homo sapiens (Human) astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; cytoplasmic translational initiation [GO:0002183]; hippocampus development [GO:0021766]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] AAPVVAPPGVVVSR 1 1.9 0.0045662 1.2391 0 0 0 0 0 0 0 0 0 7.7811 0 0 Q13145 BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (Non-metastatic gene A protein) (Putative transmembrane protein NMA) BAMBI NMA Homo sapiens (Human) cell migration [GO:0016477]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; regulation of cell shape [GO:0008360]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] frizzled binding [GO:0005109]; type II transforming growth factor beta receptor binding [GO:0005114] AAVIAVPIAGGLILVLLIMLALRMLR 1 10 0.84232 -0.043106 0 0 3.73433 0 0 0 5.61933 0 0 0 0 0 Q13148 TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) TARDBP TDP43 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380] chromatin [GO:0000785]; cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] TSDLIVLGLPWK 1 2.9 0.033028 0.56451 8.96648 0 0 0 0 0 0 8.58511 8.74143 0 0 0 Q13151 ROA0_HUMAN Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) HNRNPA0 HNRPA0 Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; inflammatory response [GO:0006954]; mRNA processing [GO:0006397]; response to lipopolysaccharide [GO:0032496] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] EDIYSGGGGGGSR;GGYGGGGGYGGSSF;LFVGGLK 3 11.1 0.95199 -0.74687 4.35346 7.33923 0 0 0 0 0 0 2.85296 9.08103 10.7754 0 Q13162 PRDX4_HUMAN Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) PRDX4 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; I-kappaB phosphorylation [GO:0007252]; male gonad development [GO:0008584]; negative regulation of male germ cell proliferation [GO:2000255]; protein maturation by protein folding [GO:0022417]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular sequestering activity [GO:0140313]; thioredoxin peroxidase activity [GO:0008379] GLFIIDDKGILR;QITLNDLPVGR;SVDETLR 3 11.1 0 2.8837 0 0 0 0 0 0 0 0 0 9.25871 0 0 Q13163 MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) MAP2K5 MEK5 MKK5 PRKMK5 Homo sapiens (Human) cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] spindle [GO:0005819] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ILHRDVKPSNMLVNTR 1 3.6 0.81237 -0.013335 0 0 0 0 0 0 0 10.7924 0 0 0 0 Q13164 MK07_HUMAN Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) MAPK7 BMK1 ERK5 PRKM7 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EAIVAEIEDFHARR;MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 2 6.8 0.78247 0.022153 0 7.63967 11.6173 0 0 0 0 0 0 0 0 0 Q13177 PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] PAK2 Homo sapiens (Human) adherens junction assembly [GO:0034333]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress fiber assembly [GO:0051497]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein autophosphorylation [GO:0046777]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activator activity [GO:0030296]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] LLQTSNITK;SVIDPVPAPVGDSHVDGAAK;TIVSIGDPK;YLSFTPPEK 4 9 0.031481 0.5768 0 11.3382 11.3279 0 9.87546 0 9.80024 0 0 0 0 0 Q13183 S13A2_HUMAN Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) SLC13A2 NADC1 SDCT1 Homo sapiens (Human) alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; fumarate transmembrane transporter activity [GO:0015138]; low-affinity sodium:dicarboxylate symporter activity [GO:0015361]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] APLGLLDWK;SYLIVFFVPILLLPLPILVPSK 2 5.2 0.93524 -0.52086 4.12871 0 0 0 0 0 0 0 0 0 7.98111 0 Q13185 CBX3_HUMAN Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) CBX3 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; rhythmic process [GO:0048511] "chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; site of DNA damage [GO:0090734]; spindle [GO:0005819]" chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription coregulator binding [GO:0001221] IIGATDSSGELMFLMK;KVEEAEPEEFVVEK;SLSDSESDDSK 3 22.4 0 1.8184 0 0 0 0 0 0 0 11.9379 0 0 7.75047 0 Q13188 STK3_HUMAN Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 Homo sapiens (Human) apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hippo signaling [GO:0035332]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription regulator activator activity [GO:0140537] EIEELRQRYTAK;YYGSYFK 2 3.9 0.60152 0.17759 0 0 0 0 0 0 0 0 0 0 2.34945 0 Q13190 STX5_HUMAN Syntaxin-5 STX5 STX5A Homo sapiens (Human) "early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; regulation of Golgi organization [GO:1903358]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]" cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]; vesicle [GO:0031982] cadherin binding [GO:0045296]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] DLSNTFAKLEKLTILAK;DRTQEFLSACK;QDINSLNK 3 10.1 0.96558 -1.1233 0 0 0 0 7.31832 0 0 0 8.487 0 0 0 Q13191 CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) CBLB RNF56 Nbla00127 Homo sapiens (Human) "CD4-positive, alpha-beta T cell proliferation [GO:0035739]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of T cell receptor signaling pathway [GO:0050860]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell anergy [GO:0002669]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation protein catabolic process at postsynapse [GO:0140252]; signal transduction [GO:0007165]; T cell anergy [GO:0002870]; T cell receptor signaling pathway [GO:0050852]" cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LILSKYDDNQK;MYEEQSQDRRNLTK;RHDLPLEGAK;SILREFAFPPPVSPRLNL 4 5.4 0.94471 -0.63658 0 0 11.8724 8.73366 0 0 0 0 0 8.2636 0 0 Q13200 PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) PSMD2 TRAP2 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; secretory granule lumen [GO:0034774]" enzyme regulator activity [GO:0030234] AVPLALALISVSNPR;DPNNLFMVR;DTSLYRPALEELR;FGGSGSQVDSAR;QLQDELEMLVERLGEKDTSLYRPALEELR;TITGFQTHTTPVLLAHGER;VGQAVDVVGQAGKPK;VPDDIYK 8 11.7 0 9.1453 9.31329 9.37905 12.9677 0 0 0 12.2665 11.5484 8.36842 5.67534 0 12.4427 Q13201 MMRN1_HUMAN Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] MMRN1 ECM EMILIN4 GPIA* MMRN Homo sapiens (Human) blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of wound healing [GO:0061045]; positive regulation of platelet aggregation [GO:1901731] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023] ESLRGECEDMLSK;EVHEQLLSTEQVSDQK;ISNPVYRMQHK;LVEENALAPDFSK;VSEDKSR 5 4.9 0.97175 -1.3536 0 7.37365 10.5068 0 0 0 0 9.61125 8.78764 0 8.24174 0 Q13206 DDX10_HUMAN Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) DDX10 Homo sapiens (Human) anterior head development [GO:0097065]; rRNA processing [GO:0006364] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DKEVFDVSK;EVPTQFLDR;ITFTDEGELVQQWPQMQK;LMQNYEK;SSEDSDSEDMENK 5 6.4 0.97156 -1.3516 12.0196 0 10.5604 0 3.11117 6.54282 0 0 7.93458 0 0 0 Q13207 TBX2_HUMAN T-box transcription factor TBX2 (T-box protein 2) TBX2 Homo sapiens (Human) aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; cardiac jelly development [GO:1905072]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle tissue development [GO:0048738]; cell fate specification [GO:0001708]; cellular response to dexamethasone stimulus [GO:0071549]; cellular senescence [GO:0090398]; cochlea morphogenesis [GO:0090103]; developmental growth involved in morphogenesis [GO:0060560]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart looping [GO:0001947]; mammary placode formation [GO:0060596]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation involved in lung development [GO:0060916]; muscle cell fate determination [GO:0007521]; negative regulation of cardiac chamber formation [GO:1901211]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of heart looping [GO:1901208]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; pigment metabolic process involved in pigmentation [GO:0043474]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; smooth muscle cell differentiation [GO:0051145]; ureteric peristalsis [GO:0072105] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AAGGNSR;DEGRKEAAEGK;IDNNPFAKGFRDTGNGR;ITQLKIDNNPFAKGFR;LTEPERARER;SCAADSDPEPER;SLKSLEPEDEVEDDPK 7 11 0.97532 -4.2643 0 0 3.91303 0 0 9.20127 10.4479 0 0 4.83643 8.65535 12.1947 Q13214 SEM3B_HUMAN Semaphorin-3B (Sema A(V)) (Semaphorin-V) (Sema V) SEMA3B SEMA5 SEMAA Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; chemorepulsion of axon [GO:0061643]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] LDPGRIEDGKGK;TEPHDSRWLNEPK 2 3.3 0.97241 -2.6802 0 0 0 0 0 0 0 10.4931 0 0 0 0 Q13216 ERCC8_HUMAN DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) ERCC8 CKN1 CSA Homo sapiens (Human) DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of transcription-coupled nucleotide-excision repair [GO:0090262]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription-coupled nucleotide-excision repair [GO:0006283] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ASGCLITLDQHNGK;YMLSGGSDGVIVLYDLENSSR 2 8.8 0.77673 0.042614 0 13.1616 0 0 0 0 0 0 0 0 5.59464 0 Q13217 DNJC3_HUMAN "DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)" DNAJC3 P58IPK PRKRI Homo sapiens (Human) cellular response to cold [GO:0070417]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; protein folding in endoplasmic reticulum [GO:0034975]; proteolysis involved in protein catabolic process [GO:0051603]; response to unfolded protein [GO:0006986] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790] misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087] ATVFLAMGK;EVLSDPEMRK;ILEVCVWDAELRELR;KLNKLIESAEELIR;QGKLDEAEDDFKK;SKAALPDLTK 6 14.1 0.9559 -0.84582 0 13.1646 0 0 0 0 0 0 0 6.17728 10.1938 10.0622 Q13219 PAPP1_HUMAN Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) PAPPA Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to dexamethasone [GO:0071548]; response to follicle-stimulating hormone [GO:0032354] extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DIPHWLNPTR;DIPHWLNPTRVERVVCTAGLK;DQGEQCDDMNK;HAWSPMKDGSSPK;VLMLGGSALNHNYR 5 3.6 0.97612 -2.3364 0 8.48236 0 0 0 0 0 9.66133 10.5454 0 0 5.26866 Q13224 NMDE2_HUMAN "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)" GRIN2B NMDAR2B Homo sapiens (Human) "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine maintenance [GO:1902951]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein heterotetramerization [GO:0051290]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; late endosome [GO:0005770]; lysosome [GO:0005764]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060] amyloid-beta binding [GO:0001540]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] AECCSPK;DSVSGGGPCTNRSHIK;LSSIESDV;SFTHSDCK 4 2.6 0.97441 -2.4092 0 0 0 0 0 0 0 0 0 0 9.50849 0 Q13228 SBP1_HUMAN Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) SELENBP1 SBP Homo sapiens (Human) protein transport [GO:0015031] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730] methanethiol oxidase activity [GO:0018549]; selenium binding [GO:0008430] IYVVDVGSEPR;RLYITTSLYSAWDK;VAGGPQMIQLSLDGK;VIQVPPKK 4 10.2 0.95556 -0.98114 12.5527 0 0 0 2.90995 0 0 0 9.13848 0 10.5557 0 Q13231 CHIT1_HUMAN Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; response to bacterium [GO:0009617] extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" VGAPATGSGTPGPFTK 1 3.4 0.77703 0.043005 0 0 0 0 0 0 11.4576 0 0 0 0 0 Q13232 NDK3_HUMAN Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3) NME3 Homo sapiens (Human) apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; DNA repair [GO:0006281]; GTP biosynthetic process [GO:0006183]; mitochondrial fusion [GO:0008053]; nucleoside triphosphate biosynthetic process [GO:0009142]; UTP biosynthetic process [GO:0006228] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] EHYAELRERPFYGRLVK 1 10.1 0.53333 0.18665 0 0 0 0 0 8.17886 0 0 0 0 0 0 Q13233 M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) MAP3K1 MAPKKK1 MEKK MEKK1 Homo sapiens (Human) cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; tight junction [GO:0070160] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270] ERADWRR;NFEVESLFQKYHSRR;NKLHHHCMSIWAEECRR;NRRGPVVVKPIPVK;QPYREDTEWLK;TGKGLCATK 6 4.8 0.9729 -2.9627 12.7115 8.67895 0 0 10.8639 0 0 0 0 11.4743 0 0 Q13237 KGP2_HUMAN cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) PRKG2 PRKGR2 Homo sapiens (Human) negative regulation of chloride transport [GO:2001226]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of protein localization [GO:1903829]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; tetrahydrobiopterin metabolic process [GO:0046146] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] AITNVKTWALDREVFQNIMR;ALSLEMIQLK;NENVAFAMKCIRK;VTELERELR 4 6.8 0.97452 -3.0579 0 0 0 0 11.5543 0 0 0 8.85761 0 12.2847 0 Q13239 SLAP1_HUMAN Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP) SLA SLAP SLAP1 Homo sapiens (Human) regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784] MIRESETKK;TVDWRRVSR 2 10.7 0.9806 -1.6169 0 0 10.7432 0 0 0 12.3509 0 0 0 0 0 Q13241 KLRD1_HUMAN Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94) KLRD1 CD94 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated immunity [GO:0002228]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]" TTLWRLISGTLGIICLSLMSTLGILLK 1 15.1 0.84058 -0.045996 0 0 0 0 0 0 0 0 0 8.69157 0 0 Q13242 SRSF9_HUMAN "Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)" SRSF9 SFRS9 SRP30C Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]" nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] EIELKNR;GGEGDGR 2 6.3 0.96461 -1.2494 0 0 0 9.66012 9.83276 8.75532 8.93148 12.2416 12.4554 9.82318 9.24862 0 Q13243 SRSF5_HUMAN "Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)" SRSF5 HRS SFRS5 SRP40 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]" cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] LIVENLSSR;VSWQDLK 2 5.9 0.90915 -0.30914 0 0 11.1841 0 0 0 0 0 0 0 0 0 Q13247 SRSF6_HUMAN "Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)" SRSF6 SFRS6 SRP55 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of keratinocyte proliferation [GO:0010837]; regulation of wound healing [GO:0061041]; response to insulin [GO:0032868]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] ALDKLDGTEINGR;LIVENLSSR;LLEVDLK;TNEGVIEFR;VIVEHAR 5 13.1 0.079618 0.39756 0 12.3015 0 0 0 0 11.7231 11.5891 0 0 0 0 Q13255 GRM1_HUMAN Metabotropic glutamate receptor 1 (mGluR1) GRM1 GPRC1A MGLUR1 Homo sapiens (Human) "cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic signaling via neuropeptide [GO:0099538]" dendrite [GO:0030425]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0098872]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583] LQSPEVRSFDDYFLKLR;LRERLPK;NVPANFNEAK;SYQGSGK 4 3.4 0.97073 -1.3403 0 0 0 0 0 0 0 9.35823 0 9.20953 0 11.539 Q13258 PD2R_HUMAN Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor) PTGDR Homo sapiens (Human) adenosine metabolic process [GO:0046085]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; male sex determination [GO:0030238]; mast cell degranulation [GO:0043303]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sleep [GO:0030431] membrane [GO:0016020]; plasma membrane [GO:0005886] prostaglandin D receptor activity [GO:0004956]; prostaglandin J receptor activity [GO:0001785] CSNSTNMESSL;KSPFYRCQNTTSVEK;TSEEAEDLRALR 3 10.6 0.97294 -2.5014 0 0 0 0 0 0 12.0044 0 2.04089 0 12.327 0 Q13261 I15RA_HUMAN Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)] IL15RA Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; interleukin-15-mediated signaling pathway [GO:0035723]; natural killer cell differentiation [GO:0001779]; negative regulation of neuron projection development [GO:0010977]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; response to nutrient levels [GO:0031667] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; protein kinase binding [GO:0019901] SVEHADIWVK;SYSLYSRERYICNSGFK 2 11.7 0.84646 -0.064994 0 0 7.51861 0 0 0 9.07847 0 0 0 0 0 Q13261 I15RA_HUMAN Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)] IL15RA Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; interleukin-15-mediated signaling pathway [GO:0035723]; natural killer cell differentiation [GO:0001779]; negative regulation of neuron projection development [GO:0010977]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; response to nutrient levels [GO:0031667] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; protein kinase binding [GO:0019901] SYSLYSRERYICNSGFK;TLGLPALLLLLLLRPPATR 2 16.4 0.669 0.16878 0 6.75822 0 0 0 0 0 0 0 0 0 0 Q13263 TIF1B_HUMAN Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; suppression of viral release by host [GO:0044790] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AASAAAASAAAASAASGSPGPGEGSAGGEK;AASAAAASAAAASAASGSPGPGEGSAGGEKR;DHTVRSTGPAK;IVAERPGTNSTGPAPMAPPR;LDLDLTADSQPPVFK;LSPANQR;LSPPYSSPQEFAQDVGR;MNEAFGDTK;SAEAFGK;SGEGEVSGLMR;VLVNDAQK 11 16.3 0 134.2 11.5253 11.3749 11.4916 10.5009 10.1877 10.4107 12.0568 11.2076 10.4228 12.1975 0 10.4976 Q13268 DHRS2_HUMAN "Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1)" DHRS2 SDR25C1 Homo sapiens (Human) C21-steroid hormone metabolic process [GO:0008207]; cellular response to oxidative stress [GO:0034599]; electron transport chain [GO:0022900]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to toxic substance [GO:0009636] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" AMAKLQGEGLSVAGIVCHVGK;TLALELAPKDIRVNCVVPGIIK 2 15.4 0.89787 -0.25422 0 0 0 0 0 8.00265 0 0 10.8342 0 0 0 Q13275 SEM3F_HUMAN Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV) SEMA3F Homo sapiens (Human) axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; positive regulation of cell migration [GO:0030335]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] ILLKDEDHDR;RAQDYIFYLEPER 2 3.1 0.91782 -0.35896 0 0 0 0 0 0 9.81501 8.6393 0 0 0 0 Q13277 STX3_HUMAN Syntaxin-3 STX3 STX3A Homo sapiens (Human) exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neuron projection development [GO:0031175]; organelle membrane fusion [GO:0090174]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of gene expression [GO:0010468]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] apical plasma membrane [GO:0016324]; azurophil granule [GO:0042582]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; vacuole [GO:0005773]; zymogen granule membrane [GO:0042589] arachidonate binding [GO:0050544]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] KKLIIIIVLVVVLLGILALIIGLSVGLN 1 9.7 0.70928 0.15938 0 0 0 0 0 0 3.63087 0 3.75221 0 0 0 Q13283 G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) G3BP1 G3BP Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of type I interferon production [GO:0032481]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perikaryon [GO:0043204] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/RNA helicase activity [GO:0033677]; double-stranded DNA helicase activity [GO:0036121]; endonuclease activity [GO:0004519]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded 3'-5' DNA helicase activity [GO:1990518] EAGEQGDIEPR;LPNFGFVVFDDSEPVQK;NLPPSGAVPVTGIPPHVVK;TFSWASVTSK 4 12.2 0.91325 -0.38413 0 10.3014 0 0 0 0 0 0 0 0 10.4775 0 Q13285 STF1_HUMAN Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) NR5A1 AD4BP FTZF1 SF1 Homo sapiens (Human) adrenal gland development [GO:0030325]; calcineurin-mediated signaling [GO:0097720]; female gonad development [GO:0008585]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; maintenance of protein location in nucleus [GO:0051457]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of female gonad development [GO:2000195]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary sex determination [GO:0007538]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" EYLYHKHLGNEMPRNNLLIEMLQAK;HYTCTESQSCK 2 7.8 0.2033 0.33077 0 8.65814 6.67582 5.2575 0 0 0 0 0 0 0 0 Q13287 NMI_HUMAN N-myc-interactor (Nmi) (N-myc and STAT interactor) NMI Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein K48-linked ubiquitination [GO:0070936]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] DDTQQILKEHSPDEFIKDEQNK;INVTEIPDTLREDQMRDK;LETELQEATK;MEADKDDTQQILK 4 17.9 0.91529 -0.39313 0 0 0 0 8.22164 0 0 9.93004 0 0 0 10.3917 Q13291 SLAF1_HUMAN Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150) SLAMF1 SLAM Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; myeloid dendritic cell activation involved in immune response [GO:0002277]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; phagocytosis [GO:0006909]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; regulation of vesicle fusion [GO:0031338] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; cell adhesion mediator activity [GO:0098631]; identical protein binding [GO:0042802]; SH2 domain binding [GO:0042169]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] FCLQLRLYEQVSTPEIK;SLENSVENK;TDPSETKPWAVYAGLLGGVIMILIMVVILQLRRR;VLLPLTYERINKSMNK 4 22.7 0.9809 -1.7593 9.61335 0 0 0 0 0 0 0 0 0 8.03744 0 Q13303 KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) KCNAB2 KCNA2B KCNK2 Homo sapiens (Human) NADPH oxidation [GO:0070995]; regulation of action potential [GO:0098900]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]; voltage-gated potassium channel complex [GO:0008076] aldo-keto reductase (NADPH) activity [GO:0004033]; methylglyoxal reductase (NADPH) (acetol producing) activity [GO:1990002]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] GYQWLKDKILSEEGR 1 4.1 0.44973 0.19157 0 0 0 0 0 0 0 0 0 0 8.48422 0 Q13304 GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12) GPR17 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; oligodendrocyte differentiation [GO:0048709] plasma membrane [GO:0005886] chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; receptor serine/threonine kinase binding [GO:0033612] FLAIVHPVKSLKLR;SLRQGLR 2 5.7 0.85152 -0.079269 0 0 0 0 0 9.33836 0 4.15486 0 0 0 0 Q13308 PTK7_HUMAN Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) PTK7 CCK4 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axis elongation [GO:0003401]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; convergent extension [GO:0060026]; coronary vasculature development [GO:0060976]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; lung-associated mesenchyme development [GO:0060484]; neural tube closure [GO:0001843]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] axon [GO:0030424]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; coreceptor activity [GO:0015026]; protein kinase activity [GO:0004672] RLPLLSVLLLPLLGGTQTAIVFIK 1 2.2 0.36284 0.2322 0 0 0 0 0 5.18456 0 0 0 0 0 0 Q13308 PTK7_HUMAN Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) PTK7 CCK4 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axis elongation [GO:0003401]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; convergent extension [GO:0060026]; coronary vasculature development [GO:0060976]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; lung-associated mesenchyme development [GO:0060484]; neural tube closure [GO:0001843]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] axon [GO:0030424]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; coreceptor activity [GO:0015026]; protein kinase activity [GO:0004672] MGSFLSGEK 1 0.8 0.93725 -0.53958 0 0 0 0 0 0 0 9.69655 0 0 0 0 Q13309 SKP2_HUMAN S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) SKP2 FBXL1 Homo sapiens (Human) defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] NQEIWGIK;NQEIWGIKCR 2 2.4 0.9812 -1.702 0 0 0 0 0 9.97642 0 0 0 0 0 0 Q13310 PABP4_HUMAN Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) blood coagulation [GO:0007596]; myeloid cell development [GO:0061515]; regulation of mRNA stability [GO:0043488]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] ALDTMNFDVIK;AVTEMNGR;EFTNVYIK;IVGSKPLYVALAQRKEER;NLDDTIDDEK;NLDDTIDDEKLRK;SLGYAYVNFQQPADAER 7 11.6 0.98026 -1.6504 0 0 0 0 0 0 0 0 0 10.0356 9.33309 0 Q13315 ATM_HUMAN Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) ATM Homo sapiens (Human) "brain development [GO:0007420]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; cellular response to reactive oxygen species [GO:0034614]; cellular response to retinoic acid [GO:0071300]; cellular response to stress [GO:0033554]; cellular response to X-ray [GO:0071481]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; female meiotic nuclear division [GO:0007143]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; male meiotic nuclear division [GO:0007140]; meiotic telomere clustering [GO:0045141]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle assembly checkpoint signaling [GO:0007094]; multicellular organism growth [GO:0035264]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA catabolic process [GO:1903626]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reciprocal meiotic recombination [GO:0007131]; regulation of apoptotic process [GO:0042981]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of microglial cell activation [GO:1903978]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere maintenance via telomerase [GO:0032210]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; somitogenesis [GO:0001756]; telomere maintenance [GO:0000723]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; site of double-strand break [GO:0035861]; spindle [GO:0005819] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AADIRRK;AVEVAGNYDGESSDELR;GAKTQEK;HRILKIYHLFVSLLLK;IIHAVTKGCCSQTDGLNSKFLDFFSK;IQTNRYTVKVQR;NMMQLCTRCLSNCTKK;QVLDLLKYLVIDNK;SLLTDCFPK;SLVLNDLLICCR;TFKNTQLPER 11 4.8 0.97495 -4.1229 11.4998 0 5.22211 11.1404 8.37186 10.4002 0 8.84881 0 0 4.27851 10.7535 Q13316 DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1) DMP1 Homo sapiens (Human) biomineral tissue development [GO:0031214]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of enamel mineralization [GO:0070173] endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178] DDDEDDSGDDTFGDDDSGPGPK;LAGGFSR 2 5.7 0.91566 -0.39444 0 0 0 0 0 0 0 8.36558 0 0 9.90764 0 Q13322 GRB10_HUMAN Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) GRB10 GRBIR KIAA0207 Homo sapiens (Human) ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of D-glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of phosphorylation [GO:0042327]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to insulin [GO:0032868]; vascular associated smooth muscle cell migration [GO:1904738] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159] NETKELRLLCAEDEQTR;SQPVHILAVRRLQEEDQQFR 2 6.2 0.97809 -2.1403 0 0 0 0 0 10.3048 0 0 0 0 0 0 Q13330 MTA1_HUMAN Metastasis-associated protein MTA1 MTA1 Homo sapiens (Human) "chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair [GO:0006302]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein autoubiquitination [GO:1902499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] LCASCWTYWKKYGGLK;TRQAFYLHTTK 2 3.8 0.8951 -0.24342 0 0 10.287 0 0 9.51017 0 0 0 0 0 0 Q13332 PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) PTPRS Homo sapiens (Human) cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron projection development [GO:0010977]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of postsynaptic density assembly [GO:0099151]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling [GO:0099537] axon [GO:0030424]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672] "chondroitin sulfate binding [GO:0035374]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" MVWEQRSATIVMMTR;QLEVPRPYIAAR;SQDGPYQIKEDITTTR;TVDVYGHVTLMRSQR;VTDARDGQSRTVR;YTVAVREAGALGPAR 6 4.4 0.96743 -1.2978 0 0 0 9.60663 0 0 3.23148 0 0 9.82262 0 8.27034 Q13336 UT1_HUMAN "Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)" SLC14A1 HUT11 JK RACH1 UT1 UTE Homo sapiens (Human) establishment of localization in cell [GO:0051649]; transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water transmembrane transporter activity [GO:0005372] AGDAARRGIAR;ALGYVTGDMK;IFYLQAKKR 3 6.7 0.97471 -3.1055 3.39218 0 0 0 0 0 3.58556 0 0 0 0 12.1548 Q13342 SP140_HUMAN Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) SP140 LYSP100 Homo sapiens (Human) defense response [GO:0006952]; regulation of transcription by RNA polymerase II [GO:0006357] fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" GLCLLPGEGEEGSDDCSEMCDGEER;LEAEFEK 2 4.2 0.71168 0.15167 0 4.84071 0 0 0 0 0 0 0 0 0 5.7289 Q13342 SP140_HUMAN Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) SP140 LYSP100 Homo sapiens (Human) defense response [GO:0006952]; regulation of transcription by RNA polymerase II [GO:0006357] fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CGSEGSDDCSEMCDGEER;ETFDLKTPQVTNEGEPEK;LEAEFEK 3 5.3 0.92973 -0.47484 0 0 0 0 9.72637 4.90949 0 0 0 0 0 6.05122 Q13347 EIF3I_HUMAN Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) EIF3I EIF3S2 TRIP1 Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]" RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] DMTMFVTASK;KPILLQGHERSITQIK 2 8 0.89335 -0.22038 0 0 0 8.50902 0 0 0 0 0 0 0 0 Q13356 PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2) PPIL2 Homo sapiens (Human) mRNA processing [GO:0006397]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; RNA splicing [GO:0008380] catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; Golgi lumen [GO:0005796]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450] KGYVRLHTNK;LDGRSLIKLNFSK;QDPSYYLK;SSQPQAGSQGPQTFRQGVGK 4 9.8 0.97666 -2.2844 0 0 0 0 0 0 0 0 0 0 11.0939 11.1952 Q13361 MFAP5_HUMAN Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2) MFAP5 MAGP2 Homo sapiens (Human) definitive hemopoiesis [GO:0060216]; embryonic eye morphogenesis [GO:0048048]; supramolecular fiber organization [GO:0097435] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527] extracellular matrix structural constituent [GO:0005201] EICSRLVCK;MSLLGPK;QMAGLPPR;VLLFLAAFIITSDWIPLGVNSQR 4 28.8 0.975 -2.3618 0 12.5448 0 0 7.99475 0 0 0 0 0 0 0 Q13362 2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) PPP2R5C KIAA0044 Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell population proliferation [GO:0008285]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]" "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]" protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] AYIRKQINNIFYR;EEHKIFLLKVLLPLHK;FSASNNRELQK;IFLLKVLLPLHK;IFLLKVLLPLHKVK;IKVPVSQPIVKK;KDRPLAR;SELPQDPHTK 8 13.1 0.9752 -3.1457 10.6696 10.4838 12.1743 10.3618 10.1178 12.6848 13.3185 12.9165 13.2615 9.94821 12.6232 12.5709 Q13367 AP3B2_HUMAN AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; presynapse [GO:0098793] AFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHR;EAASDMSPYVRK;GLHVGTPK;LFLAPKPAPVLESSFK;LYLTNSK;NVEVPEWTKCSNR;NVEVPEWTKCSNREK;SFYIRSTDPTQIK;SSSESGSGESSSESDNEDQDEDEEK 9 12.2 0.98049 -1.6098 0 9.40582 0 0 8.87891 0 11.8833 10.5834 0 0 0 0 Q13368 MPP3_HUMAN MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) MPP3 DLG3 Homo sapiens (Human) adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165] ENLYGTSLEAIQAVMAKNK;LGCRERLGGSQEGK;LGGSQEGK;YQHQPGERPR 4 7.4 0.97806 -2.1304 0 0 10.3067 6.73091 0 0 0 0 0 6.98094 0 10.4916 Q13370 PDE3B_HUMAN "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)" PDE3B Homo sapiens (Human) angiogenesis [GO:0001525]; cAMP-mediated signaling [GO:0019933]; cellular response to insulin stimulus [GO:0032869]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of lipid catabolic process [GO:0050995]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]; protein kinase B binding [GO:0043422]" YVSTSESDGTDCCSGK 1 1.4 0.6408 0.17286 0 0 0 5.75734 0 0 0 0 0 0 0 0 Q13371 PHLP_HUMAN Phosducin-like protein (PHLP) PDCL PHLOP1 PhLP1 Homo sapiens (Human) cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829] QLETEQREEQCREMER 1 5.3 0.44286 0.1945 0 0 0 0 0 0 0 0 0 0 0 8.58278 Q13387 JIP2_HUMAN C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) MAPK8IP2 IB2 JIP2 PRKM8IPL Homo sapiens (Human) "behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:0046958]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of AMPA receptor activity [GO:2000311]; regulation of JNK cascade [GO:0046328]; regulation of NMDA receptor activity [GO:2000310]; regulation of signaling receptor activity [GO:0010469]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal complex assembly [GO:0007172]; social behavior [GO:0035176]" cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] amyloid-beta binding [GO:0001540]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] RVLQTRGNVQPHLGAGQGAALNR 1 3.8 0.59888 0.17852 0 0 0 0 0 9.74955 0 0 0 0 0 0 Q13393 PLD1_HUMAN Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Homo sapiens (Human) cellular response to nutrient [GO:0031670]; chemotaxis [GO:0006935]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; positive regulation of translation [GO:0045727]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase-mediated signal transduction [GO:0007264] apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] KETETKYGIR;SLKNEPR;VTSGPSLGSLPPAAMESMESLR 3 3.6 0.88217 -0.17787 0 0 5.34142 10.109 0 9.71406 0 0 0 0 0 0 Q13395 TARB1_HUMAN Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185) TARBP1 TRM3 TRP185 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; tRNA methylation [GO:0030488] nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423] ARYLLQR;EAGPDARR;GRPAGGPDPSLQPRHR;RARYLLQR;SLDLTQYCFPEK 5 2.7 0.97593 -4.4485 10.2911 0 0 11.2962 0 9.47557 0 0 0 0 10.4063 0 Q13402 MYO7A_HUMAN Unconventional myosin-VIIa MYO7A USH1B Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; auditory receptor cell stereocilium organization [GO:0060088]; cochlea development [GO:0090102]; endocytosis [GO:0006897]; equilibrioception [GO:0050957]; eye photoreceptor cell development [GO:0042462]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mechanoreceptor differentiation [GO:0042490]; phagolysosome assembly [GO:0001845]; pigment granule transport [GO:0051904]; protein localization [GO:0008104]; sensory organ development [GO:0007423]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin VII complex [GO:0031477]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]; stereocilium base [GO:0120044]; synapse [GO:0045202]; upper tip-link density [GO:1990435] actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; spectrin binding [GO:0030507] ELLEQMERAR;FLQSRKHCPLAIDCLQR;IEQYLLEK;VKFEEDKSYFPSIPK 4 2.3 0.9755 -3.3423 0 0 12.7727 0 0 0 0 0 0 7.84574 0 0 Q13404 UB2V1_HUMAN Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A) UBE2V1 CROC1 UBE2V UEV1 P/OKcl.19 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151] AATTGSGVK;LLEELEEGQK;VVLQELR;WTGMIIGPPR;YPEAPPFVR 5 30.6 0 1.9955 11.6932 11.9626 11.5821 0 0 0 11.707 10.5213 10.1333 15.9083 0 0 Q13404 UB2V1_HUMAN Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A) UBE2V1 CROC1 UBE2V UEV1 P/OKcl.19 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151] FHCKGSKSPSQFR;LLEELEEGQK;VVLQELR;WTGMIIGPPR;YPEAPPFVR 5 28.8 0.86919 -0.091336 0 0 0 0 0 0 0 6.32021 0 0 0 0 Q13405 RM49_HUMAN "Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1)" MRPL49 C11orf4 NOF1 OK/SW-cl.67 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] AATMFRATLR;MAATMFR 2 6.6 0.98077 -1.636 8.26992 0 0 0 0 0 0 0 0 0 0 0 Q13409 DC1I2_HUMAN "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 DNCI2 DNCIC2 Homo sapiens (Human) microtubule-based movement [GO:0007018]; transport along microtubule [GO:0010970] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; microtubule [GO:0005874]; vesicle [GO:0031982] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777] TLAEINANR;TLAEINANRADAEEEAATR 2 3 0.95347 -0.78147 0 0 0 0 0 0 0 0 0 10.3362 0 0 Q13410 BT1A1_HUMAN Butyrophilin subfamily 1 member A1 (BT) BTN1A1 BTN Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] LEDSRQK;LYNERPRERR;TDWAIGVCRENVMKK;TERFDSWPCVLGRETFTSGR;VSDDGEYTCFFR 5 12.2 0.97592 -1.4631 8.94134 0 0 0 0 4.88855 0 0 8.78172 0 11.0689 7.39823 Q13415 ORC1_HUMAN Origin recognition complex subunit 1 (Replication control protein 1) ORC1 ORC1L PARC1 Homo sapiens (Human) DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] LQTLSPALKAPEKTR;TYSWVGRPLLDRKLHYQTYR;VAALSGDAR;VAALSGDARR 4 5.2 0.95479 -0.82272 9.27729 0 9.15059 0 0 0 0 8.88121 6.31087 0 0 0 Q13416 ORC2_HUMAN Origin recognition complex subunit 2 ORC2 ORC2L Homo sapiens (Human) DNA replication initiation [GO:0006270]; negative regulation of transcription by RNA polymerase II [GO:0000122] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" DNA replication origin binding [GO:0003688] KERAQLLVNPK;SLTPNARGIFRLLIK;VYSFQNRKHSEK 3 6.6 0.97598 -1.4538 0 0 0 8.3689 8.55125 0 0 0 0 9.86606 7.2778 8.62275 Q13418 ILK_HUMAN Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) ILK ILK1 ILK2 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; fibroblast migration [GO:0010761]; integrin-mediated signaling pathway [GO:0007229]; mitotic spindle organization [GO:0007052]; myelination in peripheral nervous system [GO:0022011]; negative regulation of neural precursor cell proliferation [GO:2000178]; nerve development [GO:0021675]; neural precursor cell proliferation [GO:0061351]; outflow tract morphogenesis [GO:0003151]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of signal transduction [GO:0009967]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to cell cortex [GO:0072697]; substrate adhesion-dependent cell spreading [GO:0034446]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cell cortex [GO:0005938]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] ATP binding [GO:0005524]; integrin binding [GO:0005178]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102] QLNFLTK 1 1.5 0.93331 -0.51248 0 0 0 0 0 0 0 0 11.6978 0 0 0 Q13421 MSLN_HUMAN "Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]" MSLN MPF Homo sapiens (Human) cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] LSTEQLRCLAHR;LVSCPGPLDQDQQEAAR;REVEKTACPSGK 3 6.5 0.93314 -0.50731 0 0 11.142 0 0 0 4.23863 0 0 7.10234 0 0 Q13422 IKZF1_HUMAN DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Homo sapiens (Human) chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; lymphocyte differentiation [GO:0030098]; mesoderm development [GO:0007498]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] VVGDKGLSDTPYDSSASYEKENEMMK 1 9 0.95775 -1.016 0 0 0 0 10.1906 0 0 0 0 0 0 0 Q13422 IKZF1_HUMAN DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Homo sapiens (Human) chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; lymphocyte differentiation [GO:0030098]; mesoderm development [GO:0007498]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] IGSEISR;VETQSDEENGRACEMNGEECAEDLR;VETQSDEENGRACEMNGEECAEDLRMLDASGEK 3 17.7 0.97833 -2.1003 0 0 0 0 0 0 0 10.7401 0 0 0 0 Q13423 NNTM_HUMAN "NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)" NNT Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; intracellular oxygen homeostasis [GO:0032364]; NADPH regeneration [GO:0006740]; negative regulation of apoptotic process [GO:0043066]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; response to vitamin [GO:0033273]; tricarboxylic acid cycle [GO:0006099] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803] NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (Si-specific) activity [GO:0003957]; NADP binding [GO:0050661]; proton-translocating NAD(P)+ transhydrogenase activity [GO:0008750] EFIEAEMK;EIFQNEK;GITHIGYTDLPSR;MLTEQGK;TVAELEAEK;VAGAQIQGAK;VALSPAGVQNLVK 7 6.2 0.98074 -1.7785 0 12.4483 0 0 0 0 0 11.4312 11.9074 10.1718 8.01698 0 Q13424 SNTA1_HUMAN Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) SNTA1 SNT1 Homo sapiens (Human) muscle contraction [GO:0006936]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuromuscular junction development [GO:0007528]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of vasoconstriction by circulating norepinephrine [GO:0003117]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013] actin binding [GO:0003779]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; nitric-oxide synthase binding [GO:0050998]; PDZ domain binding [GO:0030165]; sodium channel regulator activity [GO:0017080]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] GSVPYDAELSFALR;RCTPNDPEPR;TIVFIIHSFLSAKVTRLGLLA 3 8.9 0.22493 0.31463 0 0 4.89487 9.25264 0 0 5.96599 8.87949 0 0 0 0 Q13425 SNTB2_HUMAN Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) SNTB2 D16S2531E SNT2B2 SNTL Homo sapiens (Human) cytoplasm [GO:0005737]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] DAWASPCHSYPLVATR;EVLLEVKFIREVTPYIK;HIAWLAEQAK 3 8 0.91697 -0.35552 8.91127 0 0 3.85679 0 9.65204 0 0 0 5.05363 0 0 Q13426 XRCC4_HUMAN "DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]" XRCC4 Homo sapiens (Human) cellular response to lithium ion [GO:0071285]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; protein localization to site of double-strand break [GO:1990166]; response to X-ray [GO:0010165] cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] FHA domain binding [GO:0070975]; identical protein binding [GO:0042802] LLNAAQEREKDIK 1 3.9 0.97784 -1.5159 0 0 0 0 10.8248 0 0 0 0 0 0 0 Q13427 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) PPIG Homo sapiens (Human) protein folding [GO:0006457]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] FDHESSPGTDEDK;HNRNEEKR;SSEREESQSR;VVFELFSDVCPK 4 5.7 0.95455 -0.90994 0 0 0 9.65989 0 0 10.5148 10.6737 0 0 11.3386 9.38204 Q13428 TCOF_HUMAN Treacle protein (Treacher Collins syndrome protein) TCOF1 Homo sapiens (Human) neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; regulation of translation [GO:0006417]; skeletal system development [GO:0001501] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110] EVKEQSGQK;GGALPPAK;GGALPPAKRAK;NPQNSTVLAR;NPQNSTVLARGPASVPSVGK;VGTQAPR 6 3.2 0.98011 -1.866 0 7.13473 11.2428 0 0 0 0 11.286 10.0657 10.1171 0 9.96473 Q13435 SF3B2_HUMAN Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) SF3B2 SAP145 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] ISLGMPVGPNAHK;LENSAAPKK;LTDDVKKEK;VPPPWLIAMQR 4 4.7 0.97953 -1.8987 0 11.2536 0 0 0 9.36984 0 10.3489 0 0 0 0 Q13438 OS9_HUMAN Protein OS-9 (Amplified in osteosarcoma 9) OS9 Homo sapiens (Human) "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836] carbohydrate binding [GO:0030246]; protease binding [GO:0002020] EMEEEEDEDEDEDEDEDER;QREMEEEEDEDEDEDEDEDERQLLGEFEK;VDEPLSCSYVLTIR;VRVRVTK 4 7.5 0.96799 -1.303 0 7.53916 6.78842 0 0 0 0 5.53207 0 0 11.241 0 Q13439 GOGA4_HUMAN Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) GOLGA4 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle transport [GO:0048193]; positive regulation of axon extension [GO:0045773]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] GTPase binding [GO:0051020]; small GTPase binding [GO:0031267] DLAVHLEAEKNK;DLHMAEK;EEELKALEDRLESESAAK;ELDSCLVRQK;ELNDVISIWEK;ENQIKSMK;IAELREELQMDQQAK;ILEREDAR;LAGAEREK;LQKLHEKELAR;NHHQQQVDSIIKEHEVSIQR;QVAEVEAQK;SLQENKNQSK;VGQEKEETVSSHFEMR;VKQEVVDVMK;VLFEYMMGR 16 8.2 0.97878 -10.587 0 10.9348 11.3717 0 11.3946 10.142 6.60912 10.7135 0 0 12.5457 11.1715 Q13442 HAP28_HUMAN 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886] RNA binding [GO:0003723] KVTQLDLDGPK;LAIIRKQR;SLDSDESEDEEDDYQQKRK 3 21 0.95405 -0.91525 0 0 0 0 0 0 0 0 7.88771 0 9.23321 0 Q13443 ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) ADAM9 KIAA0021 MCMP MDC9 MLTNG Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to lipopolysaccharide [GO:0071222]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte differentiation [GO:0030216]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; monocyte activation [GO:0042117]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein secretion [GO:0050714]; protein processing [GO:0016485]; response to antineoplastic agent [GO:0097327]; response to calcium ion [GO:0051592]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to laminar fluid shear stress [GO:0034616]; response to manganese ion [GO:0010042]; response to tumor necrosis factor [GO:0034612]; transforming growth factor beta receptor signaling pathway [GO:0007179] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein kinase C binding [GO:0005080]; SH3 domain binding [GO:0017124] ECELDPCCEGSTCK;KCHGHGVCNSNKNCHCENGWAPPNCETK;LVDAGEECDCGTPKECELDPCCEGSTCK;SFAECAYGDCCK 4 8.3 0.68539 0.16393 8.45479 0 0 0 0 0 0 9.67163 0 2.23033 5.87752 0 Q13444 ADA15_HUMAN "Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)" ADAM15 MDC15 Homo sapiens (Human) angiogenesis [GO:0001525]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell-matrix adhesion [GO:0007160]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response to tumor cell [GO:0002418]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of receptor binding [GO:1900121]; proteolysis [GO:0006508]; response to hypobaric hypoxia [GO:1990910]; tissue regeneration [GO:0042246] acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] immunoglobulin receptor binding [GO:0034987]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124] ATSSLTTGLLLSLLVLLVLVMLGASYWYR;DLVEISPNPAVTLENFLHWRRAHLLPR;LTLCPRDSSLR;VALVGLEAWTQRDLVEISPNPAVTLENFLHWRR;VLQTSLPEPLRIK 5 11.6 0.98051 -1.7958 0 10.5334 0 0 6.05409 10.9441 0 8.945 0 0 0 10.5697 Q13449 LSAMP_HUMAN Limbic system-associated membrane protein (LSAMP) (IgLON family member 3) LSAMP IGLON3 LAMP Homo sapiens (Human) cell adhesion [GO:0007155]; locomotory exploration behavior [GO:0035641]; nervous system development [GO:0007399] cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] HLTPTGR;QLPLVLLRLLCLLPTGLPVR;VQPDRKQLPLVLLR 3 9.8 0.95494 -0.83482 0 0 4.37546 4.16044 4.18698 0 10.2295 10.6007 8.49049 0 0 0 Q13451 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) FKBP5 AIG6 FKBP51 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; response to alcohol [GO:0097305]; response to bacterium [GO:0009617]; response to cocaine [GO:0042220] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] ASESFLLAAFLNLAMCYLKLR;AVECCDK;ESWEMDTKEKLEQAAIVK;VLEVNPQNKAARLQISMCQK 4 14.4 0.97818 -1.5116 0 0 0 6.90713 0 0 9.52485 0 0 6.71631 0 0 Q13459 MYO9B_HUMAN Unconventional myosin-IXb (Unconventional myosin-9b) MYO9B MYR5 Homo sapiens (Human) actin filament-based movement [GO:0030048]; lamellipodium morphogenesis [GO:0072673]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; ruffle [GO:0001726] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; Roundabout binding [GO:0048495]; small GTPase binding [GO:0031267] AVELPEK;ITTCVEMLIKEQMR;LIFHLVKVALLEDVNR;LLEALGK;LPPGLPSHLPRWAPGAR;LVSQEKDER;LYRDLHNQMIKSIK;QAMEMVGFLPATK;SLLHLHK 9 4.8 0.97272 -2.7759 10.22 12.2999 10.009 0 9.57027 0 11.6392 10.9846 9.20657 9.02284 0 0 Q13464 ROCK1_HUMAN "Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)" ROCK1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; motor neuron apoptotic process [GO:0097049]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; podocyte cell migration [GO:0090521]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatase activity [GO:0010922]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synapse maturation [GO:0090128]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939] bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] AAFEKNINTER;EAQDMLNHSEKEK;ELQERNRILENSK;KIQELQNEKETLATQLDLAETK;LEQEVNEHK;MSTGDSFETRFEK;NLTLQLEQESNKRLLLQNELK;NSLTFPDDNDISKEAK;SISQLESLNR;TSSNADK 10 10 0.97505 -2.3549 0 0 9.00546 9.72538 4.51507 8.02364 6.90473 7.00045 0 6.29868 0 9.18827 Q13469 NFAC2_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)" NFATC2 NFAT1 NFATP Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; DNA damage response [GO:0006974]; lncRNA transcription [GO:0140742]; myotube cell development [GO:0014904]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667] "14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EAAFRLGHCHPLR;ITGKTVTTTSYEKIVGNTK;KGETDIGR 3 4.4 0.90125 -0.2606 0 0 0 0 0 0 12.6248 0 10.8559 0 0 0 Q13472 TOP3A_HUMAN DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) TOP3A TOP3 Homo sapiens (Human) chromosome separation [GO:0051304]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitochondrial DNA metabolic process [GO:0032042]; resolution of DNA recombination intermediates [GO:0071139] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422] "DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]" ETRQCQALVIWTDCDR;LYEFIVR;TLERETR;VLCVAEK 4 3.4 0.97691 -2.28 0 0 0 6.85761 0 0 0 0 9.66393 0 0 0 Q13474 DRP2_HUMAN Dystrophin-related protein 2 (DRP-2) DRP2 Homo sapiens (Human) central nervous system development [GO:0007417]; synapse organization [GO:0050808]; synaptic signaling [GO:0099536] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] zinc ion binding [GO:0008270] DTSPKQR;ILAHLEDENRILQGELRR 2 2.6 0.85048 -0.075581 0 0 0 7.68713 0 0 0 5.24576 0 0 0 0 Q13477 MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) MADCAM1 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte migration [GO:2000403]; receptor clustering [GO:0043113]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] integrin binding involved in cell-matrix adhesion [GO:0098640] GASVQWR 1 1.8 0.93612 -0.51987 0 10.6177 0 0 0 0 0 0 0 0 0 0 Q13480 GAB1_HUMAN GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) GAB1 Homo sapiens (Human) angiogenesis [GO:0001525]; endothelial cell chemotaxis [GO:0035767]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; response to hepatocyte growth factor [GO:0035728]; signal transduction [GO:0007165]; vascular endothelial growth factor signaling pathway [GO:0038084] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829] signaling adaptor activity [GO:0035591] EAWTDGRQSTESETPAK;STSSETDCNDNVPSHK 2 4.8 0.95178 -0.70039 0 0 0 0 0 0 0 10.8973 0 0 0 0 Q13485 SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) SMAD4 DPC4 MADH4 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; cellular response to transforming growth factor beta stimulus [GO:0071560]; developmental growth [GO:0048589]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endothelial cell activation [GO:0042118]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway [GO:0097191]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; in utero embryonic development [GO:0001701]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesendoderm development [GO:0048382]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac myofibril assembly [GO:1905305]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; ovarian follicle development [GO:0001541]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair follicle development [GO:0051797]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; secondary palate development [GO:0062009]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein signal transduction [GO:0060395]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412] activin responsive factor complex [GO:0032444]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; collagen binding [GO:0005518]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; filamin binding [GO:0031005]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sulfate binding [GO:0043199]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]" APGDAVHKIYPSAYIKVFDLR;GEGDVWVRCLSDHAVFVQSYYLDR;QSIKETPCWIEIHLHR;RAIESLVK 4 12.5 0.97615 -2.2959 0 10.6484 0 0 0 0 0 0 4.90323 11.599 0 13.7873 Q13487 SNPC2_HUMAN snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) SNAPC2 SNAP45 Homo sapiens (Human) snRNA transcription [GO:0009301]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase II general transcription initiation factor activity [GO:0016251] YLSSVSR 1 2.1 0.94107 -0.58955 0 0 0 0 10.8753 0 0 0 0 0 0 0 Q13488 VPP3_HUMAN V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) TCIRG1 ATP6N1C ATP6V0A3 Homo sapiens (Human) apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; B cell differentiation [GO:0030183]; bone resorption [GO:0045453]; cellular defense response [GO:0006968]; cellular response to cytokine stimulus [GO:0071345]; dentin mineralization [GO:0097188]; enamel mineralization [GO:0070166]; establishment of cell polarity [GO:0030010]; establishment of vesicle localization [GO:0051650]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lysosomal lumen acidification [GO:0007042]; macroautophagy [GO:0016236]; memory T cell activation [GO:0035709]; optic nerve development [GO:0021554]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; pH reduction [GO:0045851]; phagosome acidification [GO:0090383]; positive regulation of cell population proliferation [GO:0008284]; protein catabolic process in the vacuole [GO:0007039]; protein localization to organelle [GO:0033365]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proton transport [GO:0010155]; response to silver ion [GO:0010272]; retina development in camera-type eye [GO:0060041]; ruffle organization [GO:0031529]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T-helper 1 cell activation [GO:0035711]; tooth eruption [GO:0044691]; vacuolar acidification [GO:0007035] "apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" GRLPAPPPRDLLR 1 1.6 0.76969 0.055985 0 0 0 10.3716 10.2609 0 0 0 0 0 0 0 Q13490 BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 Homo sapiens (Human) "apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; non-canonical NF-kappaB signal transduction [GO:0038061]; placenta development [GO:0001890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; XY body [GO:0001741] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CFCCDGGLRCWESGDDPWVEHAKWFPR;ILTTGENYK 2 5.8 0.88155 -0.15295 0 0 0 0 0 0 0 0 0 0 10.8938 0 Q13491 GPM6B_HUMAN Neuronal membrane glycoprotein M6-b (M6b) GPM6B M6B Homo sapiens (Human) axon development [GO:0061564]; central nervous system myelination [GO:0022010]; extracellular matrix assembly [GO:0085029]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of serotonin uptake [GO:0051612]; nervous system development [GO:0007399]; ossification [GO:0001503]; positive regulation of bone mineralization [GO:0030501]; protein transport [GO:0015031]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893] membrane raft [GO:0045121]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886] structural constituent of myelin sheath [GO:0019911] EEQELQDIQSRSKEQLNSYT 1 6.1 0.47069 0.19077 0 0 7.71994 0 0 0 0 0 0 0 0 0 Q13492 PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) PICALM CALM Homo sapiens (Human) amyloid-beta clearance by transcytosis [GO:0150093]; axonogenesis [GO:0007409]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of gene expression [GO:0010629]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Ras protein signal transduction [GO:0046579]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle maturation [GO:0016188]; vesicle budding from membrane [GO:0006900]; vesicle cargo loading [GO:0035459]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; clathrin coat of coated pit [GO:0030132]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982] "1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156]" ATTLSNAVSSLASTGLSLTK;AVSYRQVAFDFTK;LTGGSNWQPK 3 6.6 0.9645 -1.1783 11.5495 10.0564 0 0 0 0 0 0 0 0 0 0 Q13495 MAMD1_HUMAN Mastermind-like domain-containing protein 1 (F18) (Protein CG1) MAMLD1 CG1 CXorf6 Homo sapiens (Human) male gonad development [GO:0008584]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] SGLMAMTPER 1 1 0.93031 -0.47906 0 0 0 10.1394 0 0 0 0 0 0 0 0 Q13496 MTM1_HUMAN "Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)" MTM1 CG2 Homo sapiens (Human) autophagosome assembly [GO:0000045]; endosome to lysosome transport [GO:0008333]; intermediate filament organization [GO:0045109]; mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TOR signaling [GO:0032007]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of skeletal muscle tissue growth [GO:0048633]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein transport [GO:0015031]; regulation of vacuole organization [GO:0044088]; skeletal muscle tissue growth [GO:0048630]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; I band [GO:0031674]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "intermediate filament binding [GO:0019215]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]" ASASTSK;YNSHSLENESIKR 2 3.3 0.73515 0.11001 0 0 0 0 0 0 0 0 0 8.85387 0 0 Q13503 MED21_HUMAN Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7) MED21 SRB7 SURB7 Homo sapiens (Human) blastocyst development [GO:0001824]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] GDMLLEK 1 4.9 0.81408 0.00046867 0 0 0 0 0 0 0 10.5518 0 0 0 0 Q13505 MTX1_HUMAN Metaxin-1 (Mitochondrial outer membrane import complex protein 1) MTX1 MTX MTXN Homo sapiens (Human) inner mitochondrial membrane organization [GO:0007007]; lactation [GO:0007595]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040] cytoplasm [GO:0005737]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] GPWSSTGHVQFGK;KWYAEAMPFPLNFFLPGRMQR 2 7.3 0.78279 0.030869 0 0 0 0 0 0 8.3661 8.08592 0 0 0 0 Q13506 NAB1_HUMAN NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) NAB1 Homo sapiens (Human) endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] AAALPRTLGELQLYRILQK 1 3.9 0.85863 -0.082485 6.29409 0 0 0 0 0 0 0 0 0 0 0 Q13508 NAR3_HUMAN Ecto-ADP-ribosyltransferase 3 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 3) (ARTC3) (Mono(ADP-ribosyl)transferase 3) (NAD(P)(+)--arginine ADP-ribosyltransferase 3) ART3 TMART Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779] KPCEASSKTVVYR;MEIKYVPQLLK;NQKLEDHSEK 3 8.7 0.97454 -2.388 0 0 0 10.3639 0 0 0 0 3.0937 0 0 0 Q13509 TBB3_HUMAN Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) TUBB3 TUBB4 Homo sapiens (Human) axon guidance [GO:0007411]; dorsal root ganglion development [GO:1990791]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] axon [GO:0030424]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; netrin receptor binding [GO:1990890]; peptide binding [GO:0042277]; structural constituent of cytoskeleton [GO:0005200] AILVDLEPGTMDSVR;ALTVPELTQQMFDAK;FPGQLNADLRK;GHYTEGAELVDSVLDVVR;IMNTFSVVPSPK;ISEQFTAMFR;LAVNMVPFPR;LHFFMPGFAPLTAR;NSSYFVEWIPNNVK;YLTVATVFR 10 28.4 0.11194 0.36226 0 0 0 8.50208 0 0 0 0 0 8.22139 0 0 Q13510 ASAH1_HUMAN Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (Glycosylceramide deacylase) (EC 3.5.1.109) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] ASAH1 ASAH HSD-33 HSD33 Homo sapiens (Human) cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; fatty acid metabolic process [GO:0006631]; keratinocyte differentiation [GO:0030216]; regulation of programmed necrotic cell death [GO:0062098]; regulation of steroid biosynthetic process [GO:0050810]; sphingosine biosynthetic process [GO:0046512] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] "fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; N-acylsphingosine amidohydrolase activity [GO:0017040]; nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714]" AQWTEDCR;WHELMLDKAPVLKVIVNSLK;WKHPFFLDDR 3 9.2 0.96441 -1.1177 0 0 0 0 7.63001 0 7.33083 0 10.2475 0 0 0 Q13515 BFSP2_HUMAN Phakinin (49 kDa cytoskeletal protein) (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 47) (CP47) (Lens fiber cell beaded filament protein CP 49) (CP49) (Lens intermediate filament-like light) (LIFL-L) BFSP2 Homo sapiens (Human) cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; visual perception [GO:0007601] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886] structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] RVVVDLPTSASSSMPLQR;VHALEQVSQELETQLRMHLESKATR 2 10.4 0.072698 0.41526 10.8162 0 0 0 8.12743 9.04456 0 0 0 0 0 0 Q13516 OLIG2_HUMAN Oligodendrocyte transcription factor 2 (Oligo2) (Class B basic helix-loop-helix protein 1) (bHLHb1) (Class E basic helix-loop-helix protein 19) (bHLHe19) (Protein kinase C-binding protein 2) (Protein kinase C-binding protein RACK17) OLIG2 BHLHB1 BHLHE19 PRKCBP2 RACK17 Homo sapiens (Human) axon development [GO:0061564]; myelination [GO:0042552]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate commitment [GO:0048663]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; thalamus development [GO:0021794] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" LGGSGFK 1 2.2 0.81228 0.0025375 0 0 0 0 0 0 0 0 10.8539 0 0 0 Q13523 PRP4K_HUMAN Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) PRP4K KIAA0536 PRP4 PRP4B PRP4H PRPF4K Homo sapiens (Human) "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of hippo signaling [GO:0035332]; positive regulation of protein export from nucleus [GO:0046827]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; kinetochore [GO:0000776]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] AVRSYSQQLFLALKLLK;IQRQAIVQKYK;KHKHSSEEDK;SSTRSSSTKGK;TLSPGRRAK;WSPTRRR 6 6.5 0.97596 -5.0593 7.93452 0 10.0462 11.2054 11.1359 11.3976 12.1156 12.0713 0 0 7.3466 0 Q13535 ATR_HUMAN Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) ATR FRP1 Homo sapiens (Human) "cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; interstrand cross-link repair [GO:0036297]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA replication [GO:0008156]; nuclear membrane disassembly [GO:0051081]; nucleobase-containing compound metabolic process [GO:0006139]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of cellular response to heat [GO:1900034]; regulation of double-strand break repair [GO:2000779]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to arsenic-containing substance [GO:0046685]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; telomere maintenance [GO:0000723]" ATR-ATRIP complex [GO:0070310]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALHYLKNETEIELGSLLRQDFQGLHNELLLR;FYIMMCKPK;KPSVVITWMSLDFYTK;KRDITAFYDSLK;LMEFNSLINK;NLKATSQHECSSSQLKASVCKPFLFLLK;QTEDRTFK;SEWTDELNTYR;SNRNKVDSMVSTVDYEDYQSVTR;TLQVLLPDLAAK 10 6.2 0.9732 -2.5336 11.9557 9.13142 0 0 0 0 0 12.5858 7.14568 0 0 11.7703 Q13536 CROC4_HUMAN Protein CROC-4 (Contingent replication of cDNA 4) (MIR9-1 host gene) MIR9-1HG C1orf61 CROC4 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] TSQVPDVMAPQHDQEK 1 10.3 0.59986 0.17734 0 0 9.73781 0 0 0 0 0 0 0 0 0 Q13546 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) RIPK1 RIP RIP1 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; regulation of ATP:ADP antiporter activity [GO:0070926]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ripoptosome [GO:0097342] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625] IILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIK;SLKKEYSNENAVVK 2 7.5 0.96281 -1.1003 0 11.2898 0 0 0 0 0 0 0 0 0 11.7801 Q13547 HDAC1_HUMAN Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) HDAC1 RPD3L1 Homo sapiens (Human) "cellular response to platelet-derived growth factor stimulus [GO:0036120]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Krueppel-associated box domain binding [GO:0035851]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]" IACEEEFSDSEEEGEGGRKNSSNFK;ISICSSDKR;MAQTQGTRR 3 8.9 0.9533 -0.77811 0 0 6.11034 0 8.93517 0 0 0 0 0 0 0 Q13554 KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) CAMK2B CAM2 CAMK2 CAMKB Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neuron projection development [GO:0010976]; positive regulation of synapse maturation [GO:0090129]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transport [GO:0051924]; regulation of dendritic spine development [GO:0060998]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuron migration [GO:2001222]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of skeletal muscle adaptation [GO:0014733]; regulation of synapse structural plasticity [GO:0051823]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum membrane [GO:0033017] actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310] ATTVTCTR;GAILTTMLATRNFSAR 2 5.3 0.95469 -0.8224 8.73589 0 0 0 0 0 0 0 8.8205 0 0 0 Q13555 KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) CAMK2G CAMK CAMK-II CAMKG Homo sapiens (Human) cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; nervous system development [GO:0007399]; regulation of calcium ion transport [GO:0051924]; regulation of neuron projection development [GO:0010975]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of skeletal muscle adaptation [GO:0014733]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310] ITEQLIEAINNGDFEAYTK 1 3.4 0.78387 0.022411 0 0 0 7.21296 0 7.70376 0 0 0 0 0 0 Q13557 KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) CAMK2D CAMKD Homo sapiens (Human) cardiac muscle cell contraction [GO:0086003]; cellular response to calcium ion [GO:0071277]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cell growth [GO:0001558]; regulation of cellular localization [GO:0060341]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of the force of heart contraction [GO:0002026]; regulation of transcription by RNA polymerase II [GO:0006357]; relaxation of cardiac muscle [GO:0055119]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel inhibitor activity [GO:0019871]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325] ESTESSNTTIEDEDVK;LTQYMDGSGMPKTMQSEETR 2 7.2 0.80726 0.012105 0 0 0 0 0 0 0 0 7.54944 0 9.38547 0 Q13561 DCTN2_HUMAN Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) DCTN2 DCTN50 Homo sapiens (Human) melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; vesicle [GO:0031982] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507] YADLPGIAR 1 2.2 0.885 -0.19421 0 0 0 0 0 0 0 0 11.7337 0 0 0 Q13563 PKD2_HUMAN Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) PKD2 TRPP1 TRPP2 Homo sapiens (Human) "aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cellular response to reactive oxygen species [GO:0034614]; centrosome duplication [GO:0051298]; cilium organization [GO:0044782]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; heart looping [GO:0001947]; inorganic cation transmembrane transport [GO:0098662]; intracellular calcium ion homeostasis [GO:0006874]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055]" basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; migrasome [GO:0140494]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133] actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248] HLPLEGQPPR;LHYFRSFWNCLDVVIVVLFKFINFNR 2 3.9 0.9806 -1.6624 0 0 11.6537 0 0 0 0 0 0 0 0 0 Q13564 ULA1_HUMAN "NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)" NAE1 APPBP1 HPP1 Homo sapiens (Human) mitotic DNA replication checkpoint signaling [GO:0033314]; neuron apoptotic process [GO:0051402]; protein neddylation [GO:0045116]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]; regulation of postsynapse assembly [GO:0150052]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; ubiquitin protein ligase binding [GO:0031625] CINITKQTPSFWILAR;EFVAKEGQGNLPVR;LADVLWNSQIPLLICRTYGLVGYMR;NENGAPEDEENFEEAIK 4 13.5 0.97473 -3.7503 10.634 0 0 9.6062 0 2.77243 0 0 0 10.9772 0 0 Q13568 IRF5_HUMAN Interferon regulatory factor 5 (IRF-5) IRF5 Homo sapiens (Human) cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LFCIPWR;LFCIPWRHATR 2 2.2 0.93714 -0.53962 0 0 0 6.37278 0 0 0 0 0 0 0 0 Q13569 TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG) TDG Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; depyrimidination [GO:0045008]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of embryonic development [GO:0045995]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605] ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; G/T mismatch-specific thymine-DNA glycosylase activity [GO:0141016]; G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739]; magnesium ion binding [GO:0000287]; mismatched DNA binding [GO:0030983]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; sodium ion binding [GO:0031402]; SUMO binding [GO:0032183]; transcription coregulator activity [GO:0003712]; uracil DNA N-glycosylase activity [GO:0004844] AQDKVHYYIKLK;KSGKSAK 2 4.6 0.97274 -2.6207 0 0 0 0 0 0 0 0 0 0 0 12.1755 Q13573 SNW1_HUMAN SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) SNW1 SKIIP SKIP Homo sapiens (Human) "cellular response to retinoic acid [GO:0071300]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] enzyme binding [GO:0019899]; Notch binding [GO:0005112]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear vitamin D receptor binding [GO:0042809]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] LAPAQYIR;LQRNENR;QRVIRMVEMQK;VAAAMPVR 4 6.3 0.97468 -3.8619 0 0 9.41416 6.96509 0 0 0 0 0 7.31985 9.87018 0 Q13574 DGKZ_HUMAN Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) DGKZ DAGK6 Homo sapiens (Human) cell migration [GO:0016477]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; lipid kinase activity [GO:0001727]; metal ion binding [GO:0046872] AAEEEVVR;CKPSFRESGSRNVR;EALEMYRK;IIQSFLWYLNPR;QVSYRKAITK;SAAPLHSDQQPVPEQLR;SLQGDAAPPQGEELIEAAK;TICHYIVEAGASLMK 8 10.9 0.975 -2.3604 8.72339 11.8441 5.34024 8.9853 0 0 0 10.9452 14.717 9.37067 0 0 Q13576 IQGA2_HUMAN Ras GTPase-activating-like protein IQGAP2 IQGAP2 Homo sapiens (Human) Arp2/3 complex-mediated actin nucleation [GO:0034314]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; thrombin-activated receptor signaling pathway [GO:0070493] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; small GTPase binding [GO:0031267]" AKQWVTLVVDVNQCLEGK;FFAPKMVSEK;ITLEDVISHSKK;IYDVEQTRYKK;LEASIENLRR;QLLAPVVK;SIKLDGKGEPK;TLEQTGHVSSENK;VKVNVNLLIYLLNK;VLKNSIHEK;VNVNLLIYLLNK 11 7.4 0.97685 -4.7678 0 0 11.0928 0 10.5061 0 0 11.2225 0 10.5757 11.2784 0 Q13585 MTR1L_HUMAN Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain] GPR50 Homo sapiens (Human) cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502] SASTHHKSVFSHSK;YCYICHSLQYER 2 4.2 0.9822 -1.5857 0 0 12.3628 0 0 0 0 0 11.7178 0 5.96673 8.66729 Q13586 STIM1_HUMAN Stromal interaction molecule 1 STIM1 GOK Homo sapiens (Human) activation of store-operated calcium channel activity [GO:0032237]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of angiogenesis [GO:0045766]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sarcoplasmic reticulum membrane [GO:0033017] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protease binding [GO:0002020] DEINLAKQEAQR;DLEGLHRAEQSLHDLQER;LRDEINLAKQEAQR;QKYAEEELEQVR;WLQLTHEVEVQYYNIKK 5 8.9 0.97562 -2.3222 0 12.4057 8.2226 0 10.8006 0 7.55919 0 0 0 0 0 Q13588 GRAP_HUMAN GRB2-related adapter protein GRAP Homo sapiens (Human) cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793] epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784] VLREASGKYFLWEEK 1 6.9 0.8498 -0.079027 0 0 10.642 0 0 0 0 0 0 0 0 0 Q13591 SEM5A_HUMAN Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) axon extension [GO:0048675]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparan sulfate proteoglycan binding [GO:0043395]; semaphorin receptor binding [GO:0030215]; syndecan binding [GO:0045545] ELVVGARNYLFR;FLLEDTWTTFMK;SCDSPAPQCGGWQCEGPGMEIANCSR 3 4.7 0.90893 -0.30183 8.03425 0 0 4.20508 0 0 0 0 0 0 0 0 Q13595 TRA2A_HUMAN Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) TRA2A Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] DSYYDRGYDRGYDR 1 5 0.57771 0.18108 0 0 0 0 0 0 0 0 7.81762 0 0 0 Q13596 SNX1_HUMAN Sorting nexin-1 SNX1 Homo sapiens (Human) "early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982]" cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459] ASGGGGCSASER;AVGTQTLSGAGLLK;ELALNTAQFAK;VGKEDSSSAEFLEK;VTQYERDFER;YWEAFLPEAKAIS 6 14.2 0.95205 -0.67981 0 0 0 9.98627 0 0 0 0 0 0 0 0 Q13596 SNX1_HUMAN Sorting nexin-1 SNX1 Homo sapiens (Human) "early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982]" cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459] ASGGGGCSASER;AVGTQTLSGAGLLK;ELALNTAQFAK;VGKEDSSSAEFLEK;VTQYERDFER;WGFFLSAYLSYLF 6 13.3 0.97992 -1.8307 0 0 0 0 0 0 0 0 0 0 11.0629 8.73796 Q13601 KRR1_HUMAN KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) KRR1 HRB2 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] chromosome [GO:0005694]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IDVASIK;IDVASIKEK;ILQDDVACDIIK;TFDPYIIIRARDLIK 4 9.4 0.9767 -1.4889 0 0 11.6122 0 0 9.58577 0 0 9.69898 12.1217 0 0 Q13613 MTMR1_HUMAN "Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95)" MTMR1 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein homodimerization activity [GO:0042803]" DVMYICPFMGAVSGTLTVTDFKLYFK;LAYKQEEQSK 2 5.4 0.93165 -0.49052 0 0 0 0 5.37222 0 0 2.65164 0 0 0 0 Q13614 MTMR2_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR2 KIAA1073 Homo sapiens (Human) dendritic spine maintenance [GO:0097062]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774] "identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]" LYDPLLEYR;QGIPNESWRITKINER;TIRGFEVLVEK;VASFRSRGR 4 7 0.97505 -3.0793 0 0 0 0 0 0 0 0 9.83979 0 0 8.05235 Q13615 MTMR3_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10)" MTMR3 KIAA0371 ZFYVE10 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; macroautophagy [GO:0016236]; midbody abscission [GO:0061952]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]" GPNVDSSTDMLVEDKVK;LPKTRSYDNLTTACDNTVPLASR;VPVPSQQLFEPSR 3 4.4 0.94604 -0.65355 0 0 0 0 8.71942 0 0 10.8122 0 0 0 9.36534 Q13616 CUL1_HUMAN Cullin-1 (CUL-1) CUL1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; plasma membrane [GO:0005886]; SCF ubiquitin ligase complex [GO:0019005] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625] ESTEFLQQNPVTEYMKKAEAR;FTAFYASRHSGR;LLIQAAIVR;LRVNINVPMKTEQK;NGETINTR;SPELLAR 6 9.1 0.97456 -3.7679 6.10455 0 9.8996 0 0 8.10245 0 0 0 0 8.37034 0 Q13617 CUL2_HUMAN Cullin-2 (CUL-2) CUL2 Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; VCB complex [GO:0030891] protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] GADYMDCLYR;VVDFDETWNK 2 2.7 0.8023 0.014274 0 0 0 0 6.3889 0 0 0 0 10.0735 0 0 Q13620 CUL4B_HUMAN Cullin-4B (CUL-4B) CUL4B KIAA0695 Homo sapiens (Human) astrocyte differentiation [GO:0048708]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; neuron projection development [GO:0031175]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasomal protein catabolic process [GO:0010498]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ribosome biogenesis [GO:0042254]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] AQIHQFR;FIYGKDVFEAFYKK;FLEETNR;ISANLYKQLRQICEDHIK;LYAAEGQKLMQER;RIESLIDRDYMER;VLAKNPK;VQNKTIDGILLLIER 8 10.5 0.97693 -5.7033 0 9.39735 0 0 0 0 0 12.1857 0 0 7.48067 10.9245 Q13621 S12A1_HUMAN Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) SLC12A1 NKCC2 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:potassium:chloride symporter activity [GO:0008511] IKFADIHIIGDINIRPNK 1 1.6 0.8296 -0.024561 0 0 0 0 0 7.90491 0 0 0 0 0 0 Q13625 ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) TP53BP2 ASPP2 BBP Homo sapiens (Human) intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; positive regulation of execution phase of apoptosis [GO:1900119]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124] NGRIDSHHDNQSAVAELDR 1 1.7 0.9194 -0.43807 0 0 5.28788 0 0 0 0 0 8.61508 0 0 0 Q13634 CAD18_HUMAN Cadherin-18 (Cadherin-14) CDH18 CDH14 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] LAELYGEIESERTT;SKKEPLIISEEDVR;VQDINDNAPK 3 4.8 0.95822 -1.012 9.41633 0 0 0 0 0 0 0 0 8.0898 0 9.61809 Q13635 PTC1_HUMAN Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTCH Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal cell differentiation [GO:0045606]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spermatid development [GO:0007286]; spinal cord motor neuron differentiation [GO:0021522]; stem cell proliferation [GO:0072089] apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; caveola [GO:0005901]; ciliary membrane [GO:0060170]; dendritic growth cone [GO:0044294]; endocytic vesicle membrane [GO:0030666]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119] ASGGPAR;DGGGGEEEEENGGEEK;EGLWPPPYRPR;FLVVGLLIFGAFAVGLK;GDKETRSDK;LVIVSPR;WTLSSFAEKHYAPFLLKPK;YMHWQEELIVGGTVKNSTGK 8 7.3 0.97266 -2.6129 0 8.94254 0 9.14425 10.2725 9.07278 0 7.88862 6.88105 6.1959 11.0819 0 Q13639 5HT4R_HUMAN 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; large intestinal transit [GO:0120056]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]; regulation of appetite [GO:0032098]; regulation of postsynapse assembly [GO:0150052]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589] RAFLIILCCDDER;VVLLTFLSTVILMAILGNLLVMVAVCWDRQLR 2 11.6 0.72222 0.13285 0 0 0 0 6.22267 0 8.52689 0 0 5.63674 0 0 Q13641 TPBG_HUMAN Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1) TPBG 5T4 Homo sapiens (Human) "cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; dendrite arborization [GO:0140059]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; olfactory learning [GO:0008355]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of synapse assembly [GO:0051965]; protein localization to plasma membrane [GO:0072659]; synaptic transmission, GABAergic [GO:0051932]" axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] NLTEVPTDLPAYVR 1 3.3 0.78293 0.024225 0 0 0 0 0 0 0 0 0 9.10946 0 0 Q13642 FHL1_HUMAN Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1) FHL1 SLIM1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] AEKFDCHYCR;EVHYKNR;FDCHYCR;GLVKAPVWWPMK;GTVWHKDCFTCSNCK 5 22.7 0.97483 -3.7119 9.23434 0 0 0 3.9619 12.7071 4.45575 0 0 0 0 0 Q13642 FHL1_HUMAN Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1) FHL1 SLIM1 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] EVHYKNR;FDCHYCR;GTVWHKDCFTCSNCK;VGTMAEK 4 12.2 0.92163 -0.44688 0 10.2577 10.7655 0 0 0 0 0 0 0 0 0 Q13643 FHL3_HUMAN Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2) FHL3 SLIM2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517] focal adhesion [GO:0005925]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] ELFYEDR;FAPRCAR;GAHYCVPCYENKFAPRCAR 3 9.3 0.98084 -1.7427 0 0 8.38011 0 0 0 0 0 7.98459 8.3805 0 0 Q13671 RIN1_HUMAN Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) RIN1 Homo sapiens (Human) endocytosis [GO:0006897]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] KSNTRQCQALCMR;RLAADGSLGR 2 2.9 0.95394 -0.91973 0 0 0 0 0 0 0 5.65675 0 0 0 0 Q13671 RIN1_HUMAN Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) RIN1 Homo sapiens (Human) endocytosis [GO:0006897]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] KSNTRQCQALCMR;LELEQVRQKLLQLLR 2 3.9 0.50339 0.18871 0 0 0 0 0 0 0 0 0 7.62286 0 0 Q13683 ITA7_HUMAN Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] ITGA7 UNQ406/PRO768 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; regulation of cell shape [GO:0008360] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; metal ion binding [GO:0046872] AEIHFLK;GERAMQSER;LRAIVVTLSYSLQTPR;NITLDCARGTANCVVFSCPLYSFDR 4 4.8 0.97332 -2.5641 8.33499 0 0 0 0 2.75792 0 0 0 0 0 11.468 Q13685 AAMP_HUMAN Angio-associated migratory cell protein AAMP Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909] cell surface [GO:0009986]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] heparin binding [GO:0008201] VFCVQRPDR 1 2.1 0.909 -0.31621 0 0 0 0 0 6.51759 0 0 0 0 0 0 Q13686 ALKB1_HUMAN Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-) ALKBH1 ABH ABH1 ALKBH Homo sapiens (Human) "developmental growth [GO:0048589]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative RNA demethylation [GO:0035513]; placenta development [GO:0001890]; positive regulation of gene expression, epigenetic [GO:0141137]; regulation of mitochondrial translation [GO:0070129]; regulation of translational elongation [GO:0006448]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by tRNA modification [GO:1990983]; RNA repair [GO:0042245]; tRNA wobble cytosine modification [GO:0002101]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; euchromatin [GO:0000791]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; broad specificity oxidative DNA demethylase activity [GO:0035516]; chemoattractant activity [GO:0042056]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA N6-methyladenine demethylase activity [GO:0141131]; ferrous iron binding [GO:0008198]; oxidative RNA demethylase activity [GO:0035515]; tRNA binding [GO:0000049]; tRNA demethylase activity [GO:1990984] DISTEGFCHLDDQNSEVKRAR;LLNHAVPR 2 7.5 0.92116 -0.43981 0 0 0 0 0 0 8.9077 0 0 0 0 0 Q13698 CAC1S_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)" CACNA1S CACH1 CACN1 CACNL1A3 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; release of sequestered calcium ion into cytosol [GO:0051209]; skeletal muscle adaptation [GO:0043501]; skeletal muscle fiber development [GO:0048741]; skeletal system development [GO:0001501]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; I band [GO:0031674]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; small molecule binding [GO:0036094]; voltage-gated calcium channel activity [GO:0005245] AMLPLFHIALLVLFMVIIYAIIGLELFKGK;IFRWKCHDIVK;ILRVLRVLRPLR;MTTYGAFLHKGSFCR;TVSGDLAAEEELER;VLRVLRPLRAINR;YDFEDTEVRR 7 5.1 0.97883 -1.9168 8.96907 12.4312 0 0 0 0 0 0 5.73403 0 9.66942 0 Q13702 RAPSN_HUMAN 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205) RAPSN RNF205 Homo sapiens (Human) "chemical synaptic transmission [GO:0007268]; establishment of protein localization to postsynaptic membrane [GO:1903540]; motor neuron apoptotic process [GO:0097049]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; regulation of postsynaptic membrane organization [GO:1901626]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synaptic transmission, cholinergic [GO:0007271]" centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634] acetylcholine receptor binding [GO:0033130]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; protein-membrane adaptor activity [GO:0043495]; structural constituent of postsynaptic specialization [GO:0098879] ALDAIERAQDLAEEVGNKLSQLK;LQALPCSHIFHLR;QQIEKGLQLYQSNQTEKALQVWTK 3 14.6 0.88667 -0.19336 0 0 7.17023 0 0 0 7.28522 0 8.92047 0 0 0 Q13724 MOGS_HUMAN Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) MOGS GCS1 Homo sapiens (Human) oligosaccharide metabolic process [GO:0009311]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020] Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]; glucosidase activity [GO:0015926] AVPAEGVR;SLAASSSFYGQR;WVLAWYRAR 3 3.5 0.95649 -0.85025 10.3656 12.6836 0 0 0 0 0 0 0 0 8.82251 0 Q13733 AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) ATP1A4 ATP1AL2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transport [GO:0006811]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104] cell projection [GO:0042995]; membrane raft [GO:0045121]; photoreceptor cell cilium [GO:0097733]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm midpiece [GO:0097225] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] GGEKMQINVQEVVLGDLVEIK;KVVEFTCQTAFFVTIVVVQWADLIISKTR;MGLWGKK;TGTLTQNR;VIMVTGDHPITAK;YSVDLTKGHSHQR 6 8.8 0.96375 -1.1874 0 7.32139 0 10.1828 6.39122 0 0 0 0 0 7.65514 11.4382 Q13740 CD166_HUMAN CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166) ALCAM MEMD Homo sapiens (Human) adaptive immune response [GO:0002250]; axon extension involved in axon guidance [GO:0048846]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; motor neuron axon guidance [GO:0008045]; neuron projection extension [GO:1990138]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] LDVPQNLMFGKWK;LNLSENYTLSISNAR 2 4.8 0.9174 -0.4003 0 0 0 0 0 0 12.0704 0 0 6.71122 0 0 Q13751 LAMB3_HUMAN Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) LAMB3 LAMNB1 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; laminin-5 complex [GO:0005610] protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] CDQCQRGYCNR;NCERCQLHYFRNR 2 2 0.97832 -1.9303 0 0 0 0 0 0 6.91839 0 0 0 0 0 Q13753 LAMC2_HUMAN Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) LAMC2 LAMB2T LAMNB2 Homo sapiens (Human) cell adhesion [GO:0007155]; epidermis development [GO:0008544]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284] cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-2 complex [GO:0005607]; perinuclear region of cytoplasm [GO:0048471] heparin binding [GO:0008201] CLNCNDNTDGIHCEK;GLASLKSEMR;HPSAHDVILEGAGLR;NGFYRHR;QTGNGFRCLNCNDNTDGIHCEKCK;SQENSYQSR;TLPCGLTK 7 6.1 0.9752 -4.2572 0 2.47098 3.99557 9.80062 10.0715 0 0 9.53339 0 0 10.8488 0 Q13761 RUNX3_HUMAN Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) RUNX3 AML2 CBFA3 PEBP2A3 Homo sapiens (Human) "chondrocyte differentiation [GO:0002062]; hemopoiesis [GO:0030097]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of cell cycle [GO:0045786]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]" chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]" SFPTLPTLTESRFPDPR;VTPSTPSPR 2 6.3 0.93407 -0.50401 0 0 0 9.91204 0 0 0 0 0 11.5333 0 0 Q13769 THOC5_HUMAN THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) THOC5 C22orf19 KIAA0983 Homo sapiens (Human) monocyte differentiation [GO:0030224]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; primitive hemopoiesis [GO:0060215]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] mRNA binding [GO:0003729] HEEIDLVSLEEFYK;LDWELEQR;MCLRLFRGPSR 3 4.8 0.97803 -2.0621 0 0 11.2584 8.89112 0 0 0 0 0 10.4393 0 0 Q13772 NCOA4_HUMAN Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) NCOA4 ARA70 ELE1 RFG Homo sapiens (Human) cellular response to estrogen stimulus [GO:0071391]; cellular response to testosterone stimulus [GO:0071394]; estrogen receptor signaling pathway [GO:0030520]; intracellular iron ion homeostasis [GO:0006879]; male gonad development [GO:0008584]; protein targeting to lysosome [GO:0006622]; response to hormone [GO:0009725] autolysosome [GO:0044754]; autophagosome [GO:0005776]; chromosome [GO:0005694]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] EVKAQIHSCISR;GLENWLLK;NGMPVEPKPEPEK 3 5.4 0.93307 -0.50973 11.0611 0 0 0 8.47094 0 0 0 0 0 11.3907 0 Q13796 SHRM2_HUMAN Protein Shroom2 (Apical-like protein) (Protein APXL) SHROOM2 APXL Homo sapiens (Human) actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cell migration [GO:0016477]; cellular pigment accumulation [GO:0043482]; ear development [GO:0043583]; establishment of melanosome localization [GO:0032401]; eye pigment granule organization [GO:0008057]; lens morphogenesis in camera-type eye [GO:0002089]; melanosome organization [GO:0032438] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886] actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; ligand-gated sodium channel activity [GO:0015280] EGAEPRARPER;GSHKTLKLVVK;KQELIESISR;LLAGDEIVGINDIGLSGFRQEAICLVKGSHK;LVEVQLSGGAPWGFTLK;QEAICLVKGSHK 6 4.7 0.97583 -4.325 0 0 0 0 0 0 0 10.4886 11.8847 0 4.66647 10.9839 Q13813 SPTN1_HUMAN "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; spectrin [GO:0008091]; tertiary granule lumen [GO:1904724] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; structural constituent of cytoskeleton [GO:0005200] AGQKLIDVNHYAK;AKLNESHRLHQFFR;DLAALGDKVNSLGETAER;DLASVQALLR;DLTGVQNLRKK;DVTGAEALLERHQEHR;EANKQQNFNTGIK;ELNERWR;ELPTAFDYVEFTR;GEIDAHEDSFK;GLVSSDELAK;ITALDEFATK;LAALADQWQFLVQK;LAQFVEHWK;LFGAAEVQR;LGESQTLQQFSR;LIQEQHPEEELIK;LLEAQSHFRK;LLQAQKLVQYLR;LTVLSEERAALLELWELR;SLQQLAEER;VEVNDRQGFVPAAYVK;VLETAEDIQER 23 11.3 0.97733 -2.2334 13.3078 11.7947 14.3118 10.8695 10.3476 11.0623 0 10.2315 10.4152 12.3259 11.8347 11.4705 Q13822 ENPP2_HUMAN Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD) ENPP2 ATX PDNP2 Homo sapiens (Human) cell motility [GO:0048870]; chemotaxis [GO:0006935]; immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell migration [GO:0030334]; sphingolipid catabolic process [GO:0030149] extracellular space [GO:0005615]; plasma membrane [GO:0005886] alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; phosphodiesterase I activity [GO:0004528]; phospholipase D activity [GO:0004630]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270] GESHWVDDDCEEIK;QERPVAPPK 2 2.5 0.90957 -0.31574 0 0 0 0 0 0 10.3334 0 0 0 0 0 Q13822 ENPP2_HUMAN Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD) ENPP2 ATX PDNP2 Homo sapiens (Human) cell motility [GO:0048870]; chemotaxis [GO:0006935]; immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell migration [GO:0030334]; sphingolipid catabolic process [GO:0030149] extracellular space [GO:0005615]; plasma membrane [GO:0005886] alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; phosphodiesterase I activity [GO:0004528]; phospholipase D activity [GO:0004630]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270] GESHWVDDDCEEIK;GSRNENK 2 2.4 0.98185 -1.5883 0 0 0 0 0 0 10.4763 0 5.62448 0 0 0 Q13823 NOG2_HUMAN Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) GNL2 NGP1 Homo sapiens (Human) ribosome biogenesis [GO:0042254] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723] DDAEESSSEPEEENVGNDTK;FQEEMDTVMKDPYK;IFAKPEEQR;QQRPKKVGVR;VWQYITLMRR 5 8.6 0.97275 -2.6246 0 0 0 10.689 0 10.0214 0 0 0 9.73968 7.07916 0 Q13829 BACD2_HUMAN "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)" TNFAIP1 BACURD2 EDP1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell migration [GO:0016477]; immune response [GO:0006955]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of DNA replication [GO:0045740]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634] cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] DSYQPVCNIPIITSLKEEER;IYEETLNVLLYETPR;LAEVCCTSIVYATEK;QEIKELMAEAK;VEFPEARIYEETLNVLLYETPR;VPDNSLLEATSRSR;VRRIHVK 7 28.2 0.97784 -1.5063 13.5615 7.2751 0 0 4.24192 0 0 9.47153 0 0 0 0 Q13835 PKP1_HUMAN Plakophilin-1 (Band 6 protein) (B6P) PKP1 Homo sapiens (Human) ameloblast differentiation [GO:0036305]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome assembly [GO:0002159]; desmosome maintenance [GO:0002160]; intermediate filament bundle assembly [GO:0045110]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; transepithelial water transport [GO:0035377] adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; intermediate filament [GO:0005882]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; intermediate filament binding [GO:0019215]; lamin binding [GO:0005521]; RNA binding [GO:0003723]; structural constituent of skin epidermis [GO:0030280] QLEYNARNAYTEK;TYLNLMGKSK;VQEQVMMTVKR 3 4.6 0.91615 -0.4323 0 0 0 8.73118 9.14911 0 0 0 10.2838 8.29333 0 0 Q13838 DX39B_HUMAN Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) DDX39B BAT1 UAP56 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription export complex [GO:0000346]; U4 snRNP [GO:0005687]; U6 snRNP [GO:0005688] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein binding [GO:0043008]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]" DVQEIFR;GLAITFVSDENDAK;ILNDVQDR;ILVATNLFGR;LTLHGLQQYYVKLKDNEK 5 13.3 0 3.7542 0 0 11.5675 0 0 0 11.0893 9.56607 11.5956 0 10.9547 4.35826 Q13868 EXOS2_HUMAN Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) EXOSC2 RRP4 Homo sapiens (Human) "CUT catabolic process [GO:0071034]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723] ITEVQQK;LIASVAGSVER 2 6.1 0.9172 -0.42508 0 0 0 0 0 0 0 0 0 9.35784 0 0 Q13873 BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) BMPR2 PPH1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; artery development [GO:0060840]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lung vasculature development [GO:0060426]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; pulmonary valve development [GO:0003177]; regulation of cell population proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; semi-lunar valve development [GO:1905314]; stem cell differentiation [GO:0048863]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; caveola [GO:0005901]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protein tyrosine kinase binding [GO:1990782]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" NRNSINYERQQAQAR;VPLMEHDNIARFIVGDER 2 3.2 0.86957 -0.099191 0 0 0 4.41 0 0 8.57467 0 0 0 0 0 Q13875 MOBP_HUMAN Myelin-associated oligodendrocyte basic protein MOBP Homo sapiens (Human) central nervous system myelin formation [GO:0032289]; nervous system development [GO:0007399] mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471] structural constituent of myelin sheath [GO:0019911] EEDWICCACQK;YSICKSGCFYQK 2 12.6 0.95171 -0.7016 0 0 0 0 0 0 0 6.42026 0 9.99901 0 0 Q13882 PTK6_HUMAN Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) PTK6 BRK Homo sapiens (Human) cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; innate immune response [GO:0045087]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA replication [GO:0045740]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] LAAPCRK 1 1.6 0.78247 0.022907 0 0 0 0 0 0 0 0 8.46005 0 0 0 Q13884 SNTB1_HUMAN Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) SNTB1 SNT2B1 Homo sapiens (Human) muscle contraction [GO:0006936] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198] DLLIYDSMPR;DLLIYDSMPRR;QLEIHSPDAK;TGTRQGIETHLFR 4 6.3 0.97603 -2.2997 0 0 0 0 0 0 0 0 10.8532 9.95986 0 0 Q13885 TBB2A_HUMAN Tubulin beta-2A chain (Tubulin beta class IIa) TUBB2A TUBB2 Homo sapiens (Human) cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] AILVDLEPGTMDSVR;ALTVPELTQQMFDSK;EVDEQMLNVQNK;FPGQLNADLRK;GHYTEGAELVDSVLDVVR;INVYYNEAAGNK;IREEYPDR;ISEQFTAMFR;LAVNMVPFPR;LHFFMPGFAPLTSR;MSATFIGNSTAIQELFKR;NSSYFVEWIPNNVK;SGPFGQIFRPDNFVFGQSGAGNNWAK;TAVCDIPPR;YLTVAAIFR 15 45.2 0 3.7797 11.5224 11.2401 11.3714 10.1956 10.6017 0 11.0815 10.9753 11.0308 0 10.7548 0 Q13886 KLF9_HUMAN Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) KLF9 BTEB BTEB1 Homo sapiens (Human) cellular response to cortisol stimulus [GO:0071387]; circadian rhythm [GO:0007623]; negative regulation of keratinocyte proliferation [GO:0010839]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HKCPYSGCGK 1 4.1 0.88767 -0.19051 0 0 0 0 0 0 0 0 0 8.79207 0 0 Q13895 BYST_HUMAN Bystin BYSL ENP1 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of protein localization to nucleolus [GO:1904749]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; stem cell proliferation [GO:0072089]; trophectodermal cell differentiation [GO:0001829]" "apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723]; snoRNA binding [GO:0030515] ELQSAVPR;HAPLADQILAGNAVRAGVREK 2 6.6 0.9339 -0.50482 0 0 0 0 0 0 8.96023 0 0 0 0 0 Q13905 RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124] DSRDGSERAPK;DTDSQRSHLSSFTMK;GKPAEVSVK;LLMELVFRLVCNGELSLAR;LSPCSSIGK;NTFFVLVRVVDELCLVELTEEILKLLMELVFR;VSKNTFFVLVRVVDELCLVELTEEILK 7 8.4 0.91577 -0.4336 0 0 11.7111 0 0 0 0 0 0 0 0 0 Q13905 RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124] DSRDGSERAPK;GKPAEVSVK;LLMELVFRLVCNGELSLAR;LSPCSSIGK;NTFFVLVRVVDELCLVELTEEILKLLMELVFR;SGGLGLR;SPEMSGK;VSKNTFFVLVRVVDELCLVELTEEILK 8 8.1 0.97243 -2.8187 11.0316 11.316 0 0 0 10.2425 0 9.79323 11.5642 0 0 0 Q13936 CAC1C_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)" CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport into cytosol [GO:0060402]; camera-type eye development [GO:0043010]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; embryonic forelimb morphogenesis [GO:0035115]; heart development [GO:0007507]; immune system development [GO:0002520]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of muscle contraction [GO:0045933]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] cytoplasm [GO:0005737]; dendrite [GO:0030425]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007] AFRVLRPLRLVSGVPSLQVVLNSIIK;ILRVLRVLRPLR;QLTLPEEDKRDIR;TLHDIGPEIR;VGEWLPAGCTAPQHAR;VLRVLRPLRAINR;VQEVAWK 7 3.9 0.84701 -0.072276 0 0 0 9.66826 0 0 0 0 0 0 0 0 Q13936 CAC1C_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)" CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport into cytosol [GO:0060402]; camera-type eye development [GO:0043010]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; embryonic forelimb morphogenesis [GO:0035115]; heart development [GO:0007507]; immune system development [GO:0002520]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of muscle contraction [GO:0045933]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] cytoplasm [GO:0005737]; dendrite [GO:0030425]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007] AFRVLRPLRLVSGVPSLQVVLNSIIK;GCGWLGSLEERER;ILRVLRVLRPLR;LSSNRER;QLTLPEEDKRDIR;TLHDIGPEIR;VLRVLRPLRAINR;VQEVAWK 8 4.1 0.97454 -2.3872 10.2359 0 8.09381 4.96708 8.09186 0 11.91 8.46781 10.0676 11.1799 0 5.13237 Q13938 CAYP1_HUMAN Calcyphosin (Calcyphosine) CAPS Homo sapiens (Human) intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle [GO:0031982] calcium ion binding [GO:0005509] FFRQLDRDGSR;LDRSGDGVVTVDDLR;SGDGVVTVDDLR 3 9.5 0.97323 -2.5149 0 0 0 0 10.2597 0 0 0 10.2826 0 0 0 Q13939 CALI_HUMAN Calicin CCIN Homo sapiens (Human) cell differentiation [GO:0030154]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; spermatogenesis [GO:0007283] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EVSDVAYSGIR;YDMDDNSWTK 2 3.6 0.64804 0.17088 8.00916 0 0 4.55059 0 0 0 10.3287 0 0 0 0 Q13946 PDE7A_HUMAN "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A)" PDE7A Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" MGITLIWCLALVLIKWITSK;QNEYLSLFR 2 6.4 0.86279 -0.082912 0 0 5.1348 0 0 0 0 0 0 0 0 8.13294 Q13948 CASP_HUMAN Protein CASP CUX1 CUTL1 Homo sapiens (Human) intra-Golgi vesicle-mediated transport [GO:0006891] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] EFAEVKNQEVTIK;EREIAQLVEDVQR;LAWSESMER;QVAPLLK;SLQSENAALRISNSDLSGR 5 9 0.95835 -1.0035 0 5.3036 0 0 0 0 11.2309 0 0 11.3096 9.23599 0 Q13951 PEBB_HUMAN Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) CBFB Homo sapiens (Human) "cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]" core-binding factor complex [GO:0016513]; membrane [GO:0016020]; nucleoplasm [GO:0005654] sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713] DRPHEERQAR;LSRECEIK 2 9.9 0.98031 -1.6825 12.3011 0 0 0 0 0 0 0 0 0 0 0 Q13952 NFYC_HUMAN Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2) NFYC Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDEDVKR;VQELPLARIK 2 5.7 0.96867 -1.3298 0 0 0 7.92119 0 0 0 0 0 0 0 0 Q13972 RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) RASGRF1 CDC25 GNRP GRF1 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; long-term memory [GO:0007616]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085] ALIDKLQK;GIRLNDGHVASLGLLAR;LITIYKKPISAIPAR;RKLSLNIPIITGGK;TLATEHEALMQKYLHLLQIVETEKTVAK;TPYIMKTTK;VQSFLRGWLCR;VTVPQMIK 8 8.6 0.97503 -3.2853 12.2186 0 0 8.08667 0 0 0 9.01153 9.98456 7.78287 0 10.8407 Q13976 KGP1_HUMAN cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; cerebellum development [GO:0021549]; cGMP-mediated signaling [GO:0019934]; collateral sprouting [GO:0048668]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron migration [GO:0001764]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein phosphorylation [GO:0006468]; regulation of GTPase activity [GO:0043087]; regulation of testosterone biosynthetic process [GO:2000224]; relaxation of vascular associated smooth muscle [GO:0060087]; signal transduction [GO:0007165]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] LSEKEEEIQELK;LYRTFKDSK;MSELEEDFAK 3 4.6 0.9787 -2.0843 0 0 9.28617 10.3308 10.2304 10.971 0 10.538 0 0 0 0 Q14003 KCNC3_HUMAN Voltage-gated potassium channel KCNC3 (KSHIIID) (Potassium voltage-gated channel subfamily C member 3) (Voltage-gated potassium channel subunit Kv3.3) KCNC3 Homo sapiens (Human) action potential [GO:0001508]; cortical actin cytoskeleton organization [GO:0030866]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262] axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249] HFVGLRVLGHTLR;IFKLTRHFVGLR;ITFCPDKVEFLK;LAGLTEPEAAARFDYDPGADEFFFDR;LTRHFVGLRVLGHTLR;VVRFVRILR 6 8.7 0.95132 -0.70587 0 9.24546 0 0 0 0 0 0 0 0 0 11.247 Q14004 CDK13_HUMAN Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) CDK13 CDC2L CDC2L5 CHED KIAA1791 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; hemopoiesis [GO:0030097]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of signal transduction [GO:0009966]" cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] EIVTDKEDALDFK;LADFGLAR 2 1.4 0.94111 -0.60683 0 0 0 0 0 0 0 0 0 0 0 10.7807 Q14005 IL16_HUMAN Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Homo sapiens (Human) immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; leukocyte chemotaxis [GO:0030595]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; regulation of calcium ion transport [GO:0051924] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] CD4 receptor binding [GO:0042609]; cytokine activity [GO:0005125] ESHSRAGK;LESSWHGRPTLEKER;SFEILVR;SLSQQLDCPAGKAAGTSRPTR;YPDPFEISLAQGK 5 4.8 0.97317 -2.9397 7.1919 0 0 0 0 10.5662 11.528 0 10.609 0 9.12177 0 Q14008 CKAP5_HUMAN Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) CKAP5 KIAA0097 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; centrosome duplication [GO:0051298]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule depolymerization [GO:0007019]; microtubule polymerization [GO:0046785]; mitotic spindle organization [GO:0007052]; positive regulation of microtubule nucleation [GO:0090063]; RNA transport [GO:0050658]; spindle organization [GO:0007051] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922] cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010]; ribonucleoprotein complex binding [GO:0043021] DISAPKPGPLK;EGVIGCLDLILKWLTLR;EQRMKDEK;ERLACMEEFQKAVELMDR;FSELVMKCLWRMVR;IILLKPIIK;IILLKPIIKVLPKLFESR;LPTSAPRPTRFLRSQQELEAK;MAKATGK;TEISDKITSELVSK;VELIHGKK;VFNQPKAK 12 7.1 0.97506 -3.0842 9.35562 12.247 7.47492 8.97315 8.86817 7.64983 10.0397 8.11369 8.16957 7.6837 3.86017 11.1766 Q14012 KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) CAMK1 Homo sapiens (Human) cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; nucleocytoplasmic transport [GO:0006913]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of muscle cell differentiation [GO:0051147]; regulation of protein binding [GO:0043393]; regulation of protein localization [GO:0032880]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] LGAVEGPR;LGAVEGPRWKQAEDIR 2 4.3 0.73247 0.11555 0 12.6836 0 0 0 0 10.6434 0 0 0 0 0 Q14019 COTL1_HUMAN Coactosin-like protein COTL1 CLP Homo sapiens (Human) defense response to fungus [GO:0050832]; regulation of actin filament polymerization [GO:0030833] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427] actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme binding [GO:0019899] AAYNLVR;ELEEDFIK;EVVQNFAK;FTTGDAMSK;LFAFVRFTTGDAMSKR 5 27.5 0.84613 -0.065356 0 0 0 0 0 0 0 12.1652 0 10.2901 11.7098 0 Q14028 CNGB1_HUMAN Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 Homo sapiens (Human) "calcium ion transport [GO:0006816]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transport [GO:0006813]; protein localization to organelle [GO:0033365]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]; visual perception [GO:0007601]" ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] DLNEILVHYPESQK;MLRSNNKPK;SDTLIVPSSASGTHRKK;VALFQGCDR 4 3.9 0.97436 -3.6467 0 0 0 0 0 0 0 13.0017 0 0 0 8.57448 Q14028 CNGB1_HUMAN Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 Homo sapiens (Human) "calcium ion transport [GO:0006816]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transport [GO:0006813]; protein localization to organelle [GO:0033365]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]; visual perception [GO:0007601]" ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] VMGAGGL 1 2.3 0.82309 -0.017959 0 0 0 0 0 0 10.8363 0 0 0 0 0 Q14031 CO4A6_HUMAN Collagen alpha-6(IV) chain COL4A6 Homo sapiens (Human) cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] VSRCQVCMK 1 0.5 0.90261 -0.263 0 0 0 0 0 0 0 0 0 0 9.34871 0 Q14055 CO9A2_HUMAN Collagen alpha-2(IX) chain COL9A2 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803] AGPPGPK;DATDQHIVDVALKMLQEQLAEVAVSAKR;SLLVLLQVVVLALAQIR;SLLVLLQVVVLALAQIRGPPGER 4 8.4 0.056218 0.45483 0 0 5.44483 6.81031 0 0 6.31136 0 0 9.99365 0 0 Q14088 RB33A_HUMAN Ras-related protein Rab-33A (Small GTP-binding protein S10) RAB33A RABS10 Homo sapiens (Human) antigen processing and presentation [GO:0019882]; autophagosome assembly [GO:0000045]; Rab protein signal transduction [GO:0032482] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] NVHAVVFVYDVTK 1 5.5 0.81459 -0.0042445 0 9.93904 0 0 0 0 0 0 0 0 0 0 Q14093 CYLC2_HUMAN Cylicin-2 (Cylicin II) (Multiple-band polypeptide II) CYLC2 CYL2 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] DIEKGKEEK;KPSSTDSDSK;QPLWMYR 3 7.5 0.96587 -1.2615 11.7948 0 0 0 0 0 0 0 0 0 0 10.5766 Q14103 HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) HNRNPD AUF1 HNRPD Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to nitric oxide [GO:0071732]; cellular response to putrescine [GO:1904586]; cerebellum development [GO:0021549]; circadian regulation of translation [GO:0097167]; CRD-mediated mRNA stabilization [GO:0070934]; hepatocyte dedifferentiation [GO:1990828]; liver development [GO:0001889]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to rapamycin [GO:1901355]; response to sodium phosphate [GO:1904383]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]" chromatin [GO:0000785]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mCRD-mediated mRNA stability complex [GO:0106002]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] IFVGGLSPDTPEEK;LDPITGR 2 5.9 0 9.3321 0 0 4.89932 0 0 0 0 0 0 10.187 0 0 Q14108 SCRB2_HUMAN Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) SCARB2 CD36L2 LIMP2 LIMPII Homo sapiens (Human) aminophospholipid transport [GO:0015917]; endosome to plasma membrane protein transport [GO:0099638]; positive regulation of neuron projection development [GO:0010976]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of endosome organization [GO:1904978]; regulation of glucosylceramide catabolic process [GO:2000752]; regulation of lysosome organization [GO:1905671]; sensory perception of sound [GO:0007605] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] GETPRVEEVGPYTYR;IVEWNGK;VEEVGPYTYR 3 4.6 0.95229 -0.72459 0 0 0 0 0 9.10447 0 0 0 0 10.2654 0 Q14112 NID2_HUMAN Nidogen-2 (NID-2) (Osteonidogen) NID2 Homo sapiens (Human) basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201] VLFYTDLVNPR 1 0.8 0.27859 0.25399 0 5.40402 0 0 0 0 10.2985 0 0 0 0 2.88374 Q14114 LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) LRP8 APOER2 Homo sapiens (Human) ammon gyrus development [GO:0021541]; cellular response to cholesterol [GO:0071397]; cellular response to growth factor stimulus [GO:0071363]; chemical synaptic transmission [GO:0007268]; cytokine-mediated signaling pathway [GO:0019221]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; layer formation in cerebral cortex [GO:0021819]; lipid metabolic process [GO:0006629]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of dendrite development [GO:1900006]; positive regulation of dendritic spine morphogenesis [GO:0061003]; proteolysis [GO:0006508]; reelin-mediated signaling pathway [GO:0038026]; regulation of apoptotic process [GO:0042981]; regulation of innate immune response [GO:0045088]; response to xenobiotic stimulus [GO:0009410]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517] axon [GO:0030424]; caveola [GO:0005901]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685] amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; kinesin binding [GO:0019894]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle receptor activity [GO:0030229] CDEDDDCLDHSDEDDCPK;CDGEEECPDGSDESEATCTK;IYWCDLSYRK;SCLAAVFVCDGDDDCGDGSDER 4 7.3 0.019048 0.67464 0 0 6.44874 7.6916 0 0 5.46855 0 0 6.16991 0 7.2076 Q14116 IL18_HUMAN Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) IL18 IGIF IL1F4 Homo sapiens (Human) angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; cholesterol homeostasis [GO:0042632]; defense response to Gram-positive bacterium [GO:0050830]; establishment of skin barrier [GO:0061436]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of myoblast differentiation [GO:0045662]; neutrophil activation [GO:0042119]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of cell adhesion [GO:0030155]; sleep [GO:0030431]; T-helper 1 type immune response [GO:0042088]; triglyceride homeostasis [GO:0070328]; type 2 immune response [GO:0042092] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-18 receptor binding [GO:0045515] SDIIFFQR 1 4.1 0.91496 -0.39033 0 0 0 0 0 0 0 0 0 0 8.48212 0 Q14118 DAG1_HUMAN Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] DAG1 Homo sapiens (Human) angiogenesis involved in wound healing [GO:0060055]; axon guidance [GO:0007411]; axon regeneration [GO:0031103]; basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; cellular response to cholesterol [GO:0071397]; cellular response to mechanical stimulus [GO:0071260]; commissural neuron axon guidance [GO:0071679]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; heart morphogenesis [GO:0003007]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; morphogenesis of an epithelial sheet [GO:0002011]; morphogenesis of an epithelium [GO:0002009]; muscle attachment [GO:0016203]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; nerve development [GO:0021675]; nerve maturation [GO:0021682]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein transport [GO:0015031]; regulation of embryonic cell shape [GO:0016476]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of synapse organization [GO:0050807]; regulation of synaptic plasticity [GO:0048167]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to muscle activity [GO:0014850]; response to peptide hormone [GO:0043434]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; skeletal muscle tissue regeneration [GO:0043403] adherens junction [GO:0005912]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; collagen-containing extracellular matrix [GO:0062023]; contractile ring [GO:0070938]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystroglycan complex [GO:0016011]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383] actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; calcium ion binding [GO:0005509]; dystroglycan binding [GO:0002162]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; protein-containing complex binding [GO:0044877]; SH2 domain binding [GO:0042169]; structural constituent of muscle [GO:0008307]; tubulin binding [GO:0015631]; vinculin binding [GO:0017166]; virus receptor activity [GO:0001618] IRTTTSGVPRGGEPNQRPELK;TPRPVPRVTTK 2 3.6 0.97558 -1.4605 0 8.65689 0 9.1102 0 0 0 0 0 9.44642 0 0 Q14119 VEZF1_HUMAN Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161) VEZF1 DB1 ZNF161 Homo sapiens (Human) angiogenesis [GO:0001525]; cellular defense response [GO:0006968]; endothelial cell development [GO:0001885]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" RHESCHTGIK 1 1.9 0.88238 -0.17981 0 9.96665 0 0 0 0 0 0 0 0 0 0 Q14123 PDE1C_HUMAN "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)" PDE1C Homo sapiens (Human) cAMP-mediated signaling [GO:0019933] cytosol [GO:0005829]; lysosome [GO:0005764]; neuronal cell body [GO:0043025] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" DWLASTFTRQMGMMLRR;IVSPLIDETSQTGGTGQRR;TDAGNRK;TDKKDHSNIGNDSK 4 7.4 0.97863 -2.0852 0 7.39034 0 8.78441 0 0 0 0 0 0 0 0 Q14126 DSG2_HUMAN Desmoglein-2 (Cadherin family member 5) (HDGC) DSG2 CDHF5 Homo sapiens (Human) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; Purkinje myocyte development [GO:0003165]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to progesterone [GO:0032570] apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083] LEDRDNWISVDSVTSEIK;LPDFESR;SLQEANAEKVTQEIVTER;TLAEVCLGQKIDINKEIEQR 4 5.6 0.96837 -1.3247 0 0 0 0 0 11.2585 9.05699 8.78679 0 0 0 0 Q14134 TRI29_HUMAN Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) TRIM29 ATDC Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122] adherens junction [GO:0005912]; lysosome [GO:0005764] cadherin binding involved in cell-cell adhesion [GO:0098641]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270] DLVRDLEKQK;EQDAVDQVK;IIEIEDEAEKWQK;SLGSALKPGEGR;SPYAGLQLGAAK 5 9.5 0.93365 -0.5122 0 0 0 7.40429 0 0 0 13.3864 13.2906 10.3164 0 0 Q14135 VGLL4_HUMAN Transcription cofactor vestigial-like protein 4 (Vgl-4) VGLL4 KIAA0121 Homo sapiens (Human) negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein catabolic process [GO:0045732] nucleus [GO:0005634] transcription coactivator binding [GO:0001223] ALGDTWLQIK 1 3.4 0.92735 -0.45567 0 0 0 0 10.1655 0 0 0 0 0 0 0 Q14140 SRTD2_HUMAN SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2) SERTAD2 KIAA0127 TRIPBR2 Homo sapiens (Human) negative regulation of cell growth [GO:0030308] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] MLGKGGK 1 2.2 0.57826 0.18054 8.17822 12.0896 0 0 0 0 0 0 0 0 0 0 Q14141 SEPT6_HUMAN Septin-6 SEPTIN6 KIAA0128 SEP2 SEPT6 Homo sapiens (Human) cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; mitotic cytokinesis [GO:0000281]; protein localization [GO:0008104]; spermatogenesis [GO:0007283] axon terminus [GO:0043679]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin collar [GO:0032173]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ELHEKFDR;IGNKMMRAR;KLDSKVNIIPIIAK;LDSKVNIIPIIAKADAISK;SLDDEVNAFKQR 5 11.3 0.97794 -2.1574 0 11.4338 0 0 10.6696 0 0 8.13463 0 11.1829 9.33398 0 Q14142 TRI14_HUMAN Tripartite motif-containing protein 14 TRIM14 KIAA0129 Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335] molecular adaptor activity [GO:0060090]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EQADSCR;FDALWQVLAR;GASAAAR;LLLDEEEALAK 4 7.9 0.95525 -0.79032 0 0 0 0 0 0 0 10.1829 0 9.91151 8.87949 0 Q14145 KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) KEAP1 INRF2 KIAA0132 KLHL19 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; negative regulation of response to oxidative stress [GO:1902883]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of epidermal cell differentiation [GO:0045604]; ubiquitin-dependent protein catabolic process [GO:0006511] actin filament [GO:0005884]; centriolar satellite [GO:0034451]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; inclusion body [GO:0016234]; midbody [GO:0030496]; nucleoplasm [GO:0005654] disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IGVGVAVLNR 1 1.6 0.55369 0.18308 0 0 0 0 0 0 0 0 0 10.4545 0 0 Q14146 URB2_HUMAN Unhealthy ribosome biogenesis protein 2 homolog URB2 KIAA0133 Homo sapiens (Human) regulation of signal transduction by p53 class mediator [GO:1901796]; ribosome biogenesis [GO:0042254] aggresome [GO:0016235]; midbody [GO:0030496]; nucleolus [GO:0005730] DIFKELYNDYLK;ITAFLSSSKPYTEAASSK;LHNVLFSILQCHPK;LLLNCPLSGEK;TLMQTSFR;TVFQTYAK 6 4.7 0.973 -2.854 0 0 13.386 0 0 9.79823 0 0 8.83968 11.7295 0 0 Q14147 DHX34_HUMAN Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34) DHX34 DDX34 KIAA0134 Homo sapiens (Human) "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of phosphorylation [GO:0042327]" membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EPSLPQYEVLIVDEVHER;LLAASLRLRAR;LVADGWLELQLADSESAIR 3 4.2 0.78418 0.028902 0 0 12.0552 0 0 2.90768 0 0 0 0 0 0 Q14149 MORC3_HUMAN MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 NXP2 ZCWCC3 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cellular senescence [GO:2000774]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821] chromatin [GO:0000785]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AECSQCSNNESK;IPEDLDEITGKK;ITFGFNCRNK;NCEVPEEPEDEDLVHPTYEK;SLAYIERDVYRPKFLSK 5 7.6 0.96313 -1.0867 0 0 3.54263 0 9.63968 10.4266 0 5.34135 0 0 9.56879 0 Q14151 SAFB2_HUMAN Scaffold attachment factor B2 (SAF-B2) SAFB2 KIAA0138 Homo sapiens (Human) regulation of androgen receptor signaling pathway [GO:0060765]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell differentiation [GO:0060008] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] EPAEQPGDGER;LERERMR;SQDRKSESK;VGSGSGR;VTKSGSR;VTPDIEESLLEPENEK 6 6 0.9751 -4.1847 12.3842 10.749 7.55781 7.66881 6.87123 0 9.95862 11.2571 8.8189 10.398 0 10.4222 Q14152 EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) EIF3A EIF3S10 KIAA0139 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; translation reinitiation [GO:0002188]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; multi-eIF complex [GO:0043614]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]" mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743] AIVDAAR;ALEVIKPAHILQEK;GGADDERSSWR;ITTMQLER;LEEVERK;LESLNIQREKEELEQR;LLDMDGIIVEK;LLLTPWVK;LTSLVPFVDAFQLER;SLEDVVR 10 7.5 0.97408 -3.0109 12.103 13.5287 9.17562 10.7063 10.1668 6.95501 11.8155 8.73603 7.20134 6.00333 7.82419 11.4024 Q14153 FA53B_HUMAN Protein FAM53B (Protein simplet) FAM53B KIAA0140 SMP Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein import into nucleus [GO:0006606]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] CYSGGSVQR 1 2.1 0.93797 -0.56945 0 0 0 0 0 0 11.1205 0 0 0 0 0 Q14155 ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 Homo sapiens (Human) ephrin receptor signaling pathway [GO:0048013]; focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; lamellipodium assembly [GO:0030032]; negative regulation of microtubule nucleation [GO:1905833]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726] gamma-tubulin binding [GO:0043015]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901] LPTTGMTITK;NLSAQCQEVRKR 2 2.7 0.90923 -0.31603 0 0 12.3441 0 0 0 0 0 0 0 0 0 Q14156 EFR3A_HUMAN Protein EFR3 homolog A (Protein EFR3-like) EFR3A KIAA0143 Homo sapiens (Human) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; plasma membrane [GO:0005886] EKICRQDTSFMK;IAESLGGSGYSVERLSVPYVPQVTDEDRLSR;SLEKHEKDLYFLTNK 3 7.1 0.96669 -1.2695 0 9.05742 0 7.98082 0 0 8.89993 0 0 0 0 9.1756 Q14157 UBP2L_HUMAN Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) UBAP2L KIAA0144 NICE4 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of stress granule assembly [GO:0062029]; stress granule assembly [GO:0034063] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; PcG protein complex [GO:0031519] RNA binding [GO:0003723] KYPPPYKHFWTAES 1 1.4 0.86526 -0.0879 0 0 0 0 0 0 0 9.55317 0 0 0 0 Q14159 SPIDR_HUMAN DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) SPIDR KIAA0146 Homo sapiens (Human) cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202] nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654] CSFYATVIYQKPQLK;TITEKHLELCPRPK;TPSSLQHSEELRSEECPR 3 5.4 0.95957 -1.0456 0 0 0 0 0 5.55683 0 0 8.58203 0 0 11.5697 Q14160 SCRIB_HUMAN Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL Homo sapiens (Human) "activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cochlear nucleus development [GO:0021747]; epithelial structure maintenance [GO:0010669]; establishment of apical/basal cell polarity [GO:0035089]; establishment of T cell polarity [GO:0001768]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; polarized epithelial cell differentiation [GO:0030859]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; protein localization to adherens junction [GO:0071896]; receptor clustering [GO:0043113]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; wound healing [GO:0042060]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; myelin sheath abaxonal region [GO:0035748]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Scrib-APC-beta-catenin complex [GO:0034750] cadherin binding [GO:0045296]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591] ATPHPSELK;CNRHVESVDKR;GLGFSIAGGK;SLEQDALR;VQSPEPPAPER 5 3 0.97764 -1.4999 11.3809 12.5435 0 0 0 0 0 0 11.1362 0 0 9.99661 Q14162 SREC_HUMAN Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888] CSFRCNCHGSPCEQDSGR;GLGLLLPLLLLWTR;SSGELSSPLRKPK 3 5.4 0.95513 -0.87684 0 8.52352 4.95424 0 1.76005 0 0 0 0 0 0 0 Q14162 SREC_HUMAN Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888] CSFRCNCHGSPCEQDSGR;GLGLLLPLLLLWTR;QRPAWLQVLSRPLRTPPRHSPSR 3 9.7 0.59747 0.17852 0 0 0 0 0 0 0 7.27324 0 0 0 0 Q14164 IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) IKBKE IKKE IKKI KIAA0151 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of lipid storage [GO:0010884]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of protein-containing complex assembly [GO:0043254]; response to interferon-beta [GO:0035456]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625] AVLRKPQQK;GVLGAGYQALR;LLASDLLDNNR;VFNTTSYLRPREVQVREFEVLR 4 7.4 0.97634 -2.2929 0 5.56608 0 7.16249 0 0 10.4214 11.6558 0 0 0 0 Q14165 MLEC_HUMAN Malectin MLEC KIAA0152 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899] LLLLLLPPAIR 1 3.8 0.27879 0.25384 0 5.24226 0 0 0 0 0 10.4201 0 0 0 0 Q14168 MPP2_HUMAN MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) MPP2 DLG2 Homo sapiens (Human) excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; protein homooligomerization [GO:0051260] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] GVVAAGK;KRMMYLTTK;LIMWDPDR;LIMWDPDRYGTTVPYTSR 4 5.9 0.9799 -1.8222 0 0 0 6.09466 0 0 9.51548 0 0 0 0 0 Q14181 DPOA2_HUMAN DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) POLA2 Homo sapiens (Human) "DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]; protein import into nucleus [GO:0006606]" alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] EYSLFPGQVVIMEGINTTGR;FSRILKHILTQR;HEQVENCLLTSPFEDIFK 3 8.4 0.67126 0.16751 17.2809 17.198 16.7616 15.9661 0 6.50295 0 0 16.8911 0 8.16957 0 Q14184 DOC2B_HUMAN Double C2-like domain-containing protein beta (Doc2-beta) DOC2B DOC2BL Homo sapiens (Human) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vesicle fusion [GO:0031340]; protein localization [GO:0008104]; spontaneous neurotransmitter secretion [GO:0061669] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; syntaxin binding [GO:0019905] GERLKHWFDCLK;ISVCDEDK 2 4.9 0.96249 -1.1028 0 0 0 0 0 0 0 0 0 8.06894 0 0 Q14185 DOCK1_HUMAN Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) DOCK1 Homo sapiens (Human) "apoptotic process [GO:0006915]; cell migration [GO:0016477]; integrin-mediated signaling pathway [GO:0007229]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of postsynapse assembly [GO:0150052]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] AFFTDRYLQEHPEAHEK;AMKALESIFK;AVFTDLGSK;EEKYGVAFYNYDAR;ISFVCQIVRVGRMELR;QEDLEACCQLLSHILEVLYR;REEKYGVAFYNYDAR;SQDKLDKDDLEK;SVIYYQVK;VGRMELRDNNTR 10 6 0.97528 -3.288 0 0 0 6.84712 0 12.8343 10.7777 0 11.4914 7.80245 0 0 Q14186 TFDP1_HUMAN Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) TFDP1 DP1 Homo sapiens (Human) anoikis [GO:0043276]; epidermis development [GO:0008544]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein domain specific binding [GO:0019904]" VFIDQNLSPGK;VYDALNVLMAMNIISK 2 6.6 0.9211 -0.44453 0 0 0 11.3655 0 0 0 0 0 0 0 0 Q14188 TFDP2_HUMAN Transcription factor Dp-2 (E2F dimerization partner 2) TFDP2 DP2 Homo sapiens (Human) heart development [GO:0007507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; transcription factor binding [GO:0008134]" LDPKCDR;VYDALNVLMAMNIISK 2 6.6 0.96652 -1.2648 0 0 0 0 6.76461 0 0 0 0 0 0 0 Q14190 SIM2_HUMAN Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) SIM2 BHLHE15 Homo sapiens (Human) cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; lung development [GO:0030324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LTTSYLK;TALSTSQETR;TLYHHVHGCDVFHLRYAHHLLLVKGQVTTK 3 7 0.98001 -1.5688 0 10.3986 0 0 0 0 11.6489 0 0 9.25901 0 0 Q14191 WRN_HUMAN "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]" WRN RECQ3 RECQL2 Homo sapiens (Human) base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820] "centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]" 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403] DQTESWWKAFSR;EEEEDDENEANEGEEDDDK;ICALTKK;RQIILSHFEDK 4 3.4 0.96762 -1.3057 0 0 0 7.36466 8.14547 0 0 0 0 10.8228 0 8.8458 Q14192 FHL2_HUMAN Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) FHL2 DRAL SLIM3 Homo sapiens (Human) atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015] focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018] bHLH transcription factor binding [GO:0043425]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] DRHWHEACFHCSQCR 1 5.4 0.82947 -0.021856 0 7.11946 0 0 0 0 0 0 7.49625 7.41498 7.19849 0 Q14192 FHL2_HUMAN Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) FHL2 DRAL SLIM3 Homo sapiens (Human) atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015] focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018] bHLH transcription factor binding [GO:0043425]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] ISVCPAMR;NNMPCSAFSAK;VSSPKTIRISVCPAMR 3 17.9 0.95501 -0.79354 0 5.65469 9.32479 0 0 9.04846 0 0 0 0 8.6193 0 Q14195 DPYL3_HUMAN Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) DPYSL3 CRMP4 DRP3 ULIP ULIP1 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; cellular response to cytokine stimulus [GO:0071345]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection development [GO:0010977]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; response to axon injury [GO:0048678] cell body [GO:0044297]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; synapse [GO:0045202] "chondroitin sulfate binding [GO:0035374]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]" IVAPPGGR;LLIKGGR;MSVIWDKAVATGK;SAADLISQAR;TLDFDALSVGQR 5 7.3 0.11817 0.35988 8.73545 0 0 0 0 0 0 0 0 10.4788 0 0 Q14201 BTG3_HUMAN Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5) BTG3 ANA TOB5 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930] cytoplasm [GO:0005737]; nucleus [GO:0005634] LVRKHDK 1 2.8 0.83628 -0.035007 0 0 0 0 7.59111 0 0 0 0 0 0 0 Q14202 ZMYM3_HUMAN Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] CTTPRGTTK;DCCEDFK;GVTEQLDGSTWDFCSEDCKSK;NKAAMCKPLMQNR;YANGETSKGDELR 5 4.6 0.97371 -2.4672 0 0 11.8637 8.78878 6.0985 0 0 6.88325 6.17881 8.45389 0 0 Q14203 DCTN1_HUMAN Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) DCTN1 Homo sapiens (Human) "cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; establishment of mitotic spindle orientation [GO:0000132]; maintenance of synapse structure [GO:0099558]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; non-motile cilium assembly [GO:1905515]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuromuscular junction development [GO:1904398]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; ventral spinal cord development [GO:0021517]" axon [GO:0030424]; cell cortex [GO:0005938]; cell cortex region [GO:0099738]; cell leading edge [GO:0031252]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein complex [GO:0030286]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; spindle [GO:0005819]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631] AELKQRLNSQSK;AQSKRHVYSR;ELEKHKIQLEQVQEWK;ERYMEEMADTADAIEMATLDKEMAEER;SLSDTVEK 5 5.7 0.97586 -4.4152 0 5.2368 0 0 0 0 0 0 0 0 0 0 Q14204 DYHC1_HUMAN "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 Homo sapiens (Human) cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; establishment of spindle localization [GO:0051293]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; retrograde axonal transport [GO:0008090]; stress granule assembly [GO:0034063] axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; RNA binding [GO:0003723] AATSPALFNR;DYIPVDQEELRDYVK;EVDGLDVSK;FFEREVKMGAK;IFTIESTR;IFVFEPPPGVK;IFVGLCQVGAWGCFDEFNR;LSCLPAFK;LVEDEERRWTDENIDTVALK;MAPSVEK;MRAELGEYIR;QIREVWNTYELDLVNYQNKCR;SIPLDEGEDEAQR;SLAMTKPDR;SLSAERER;TEYLSNADERLR;TPVIDADKPVSSQLR;TYERTCEKVEER;VEPLRNELQKLEDDAK;VTDFGDK;WQALLVQIRK 21 5.4 0.9758 -4.4399 7.88179 13.9318 10.9655 10.4065 10.493 9.66621 8.60177 11.3749 0 0 0 11.3206 Q14206 RCAN2_HUMAN Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) RCAN2 DSCR1L1 ZAKI4 Homo sapiens (Human) calcium-mediated signaling [GO:0019722] cytoplasm [GO:0005737]; nucleus [GO:0005634] calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676] IIQTRRPGLPPSVSN 1 7.6 0.92026 -0.43763 0 0 0 0 0 0 0 0 0 0 6.26694 0 Q14207 NPAT_HUMAN Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) NPAT CAND3 E14 Homo sapiens (Human) cell cycle G1/S phase transition [GO:0044843]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] AFKTAVPTEQK;HTTIRETQSEKK;NLTNSSIPMKKK 3 2.5 0.97685 -2.2801 0 0 0 0 8.93089 0 0 0 8.7864 0 0 0 Q14232 EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) EIF2B1 EIF2BA Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743] IADLCHTFIK 1 3.3 0.93423 -0.50426 0 0 0 0 9.37012 0 0 0 0 0 0 0 Q14240 IF4A2_HUMAN Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) EIF4A2 DDX2B EIF4F Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic translational initiation [GO:0002183]; negative regulation of RNA-dependent RNA polymerase activity [GO:1900260]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation initiation factor activity [GO:0003743] DVIMREFR;ELAQQIQK;GIYAYGFEKPSAIQQR;GVAINFVTEEDK;GYDVIAQAQSGTGK;ILVKKEELTLEGIK;LQAEAPHIVVGTPGR;MFVLDEADEMLSR;VLITTDLLAR 9 27 0.33068 0.24398 0 0 0 0 0 8.58244 10.2719 0 8.0114 0 0 0 Q14241 ELOA1_HUMAN Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3) ELOA TCEB3 MSTP059 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] elongin complex [GO:0070449]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734] DLVAQWK;EEEMEGDYQETWK;GVVSQNK;IAPMMAK;IVKTSATALGDKGLK 5 6.3 0.97994 -1.8352 0 11.1621 0 12.0665 12.0982 11.9624 0 0 0 9.44228 4.65036 12.3053 Q14244 MAP7_HUMAN Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) MAP7 Homo sapiens (Human) establishment or maintenance of cell polarity [GO:0007163]; microtubule cytoskeleton organization [GO:0000226]; protein localization to plasma membrane [GO:0072659]; response to osmotic stress [GO:0006970] axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] AVSPSNPK;EEQLQRQAEER;LEAEQAR;LEAEQAREK;LYSPDSYKVQDK;RAVSPSNPK;VTVESTPDLEK 7 7.1 0.97605 -5.1686 0 3.43389 0 0 0 0 0 10.2158 10.5211 7.01759 0 0 Q14246 AGRE1_HUMAN Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor) ADGRE1 EMR1 TM7LN3 Homo sapiens (Human) adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] NLKVVNYFSSRNIK 1 1.6 0.86604 -0.088183 0 0 0 0 0 0 0 0 0 0 0 10.3759 Q14247 SRC8_HUMAN Src substrate cortactin (Amplaxin) (Oncogene EMS1) CTTN EMS1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of mitophagy [GO:1901524]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]" cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076] cadherin binding [GO:0045296]; profilin binding [GO:0005522] ANFENLAK;DYSSGFGGK;ELETGPK;GVCKGRYGLFPANYVELR;SAVGFEYQGK;SAVGHEYQSK;TVPVEAVTSK;YGLFPANYVELRQ;YGVQADRVDK;YGVQADRVDKSAVGFDYQGK 10 18.7 0.95434 -0.90304 0 0 0 0 11.1833 11.5779 9.52323 11.2987 0 7.35544 0 0 Q14247 SRC8_HUMAN Src substrate cortactin (Amplaxin) (Oncogene EMS1) CTTN EMS1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of mitophagy [GO:1901524]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]" cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076] cadherin binding [GO:0045296]; profilin binding [GO:0005522] ANFENLAK;DYSSGFGGK;ELETGPK;SAVGFEYQGK;SAVGHEYQSK;SCHVRWEICLCHTVTAR;TVPVEAVTSK;YGVQADRVDK;YGVQADRVDKSAVGFDYQGK 9 15.9 0.9186 -0.43566 0 0 0 0 0 0 0 0 8.76039 0 0 0 Q14254 FLOT2_HUMAN Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) FLOT2 ESA1 M17S1 Homo sapiens (Human) anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of establishment of T cell polarity [GO:1903905]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] acrosomal membrane [GO:0002080]; adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982] protease binding [GO:0002020] AEAERMK;DADIGVAEAER;DVYDKVDYLSSLGK;IAAPLTKVDEIVVLSGDNSK;MALVLEALPQIAAK;QEEIEIEVVQRK 6 18.2 0.97499 -2.3561 0 0 0 10.6532 0 8.56148 7.64407 7.9521 0 5.4079 0 0 Q14257 RCN2_HUMAN Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) RCN2 ERC55 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleolus [GO:0005730] calcium ion binding [GO:0005509] EALLGVQEDVDEYVK 1 4.7 0.84774 -0.071422 0 0 0 0 0 0 9.99873 0 0 8.46708 0 0 Q14258 TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) TRIM25 EFP RNF147 ZNF147 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to estrogen [GO:0043627]; response to oxidative stress [GO:0006979]; response to vitamin D [GO:0033280]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; RIG-I binding [GO:0039552]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ATSSHPNSTSLK;RKCSQHNR 2 3.2 0.8466 -0.065815 0 0 0 0 0 3.02373 10.5156 0 0 0 0 0 Q14289 FAK2_HUMAN Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) PTK2B FAK2 PYK2 RAFTK Homo sapiens (Human) "activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; blood vessel endothelial cell migration [GO:0043534]; bone resorption [GO:0045453]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to fluid shear stress [GO:0071498]; cellular response to retinoic acid [GO:0071300]; chemokine-mediated signaling pathway [GO:0070098]; cortical cytoskeleton organization [GO:0030865]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; glial cell proliferation [GO:0014009]; integrin-mediated signaling pathway [GO:0007229]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; neuron projection development [GO:0031175]; oocyte maturation [GO:0001556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion [GO:0030155]; regulation of cell shape [GO:0008360]; regulation of macrophage chemotaxis [GO:0010758]; regulation of postsynaptic density assembly [GO:0099151]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to cation stress [GO:0043157]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; stress fiber assembly [GO:0043149]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]" "apical dendrite [GO:0097440]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]" 3-phosphoinositide-dependent protein kinase binding [GO:0043423]; ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; glutamate receptor binding [GO:0035254]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; neurotransmitter receptor regulator activity [GO:0099602]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] CWDYDPSDRPR;NSLPQIPMLNLEAR;YDLQIRYLPEDFMESLKEDR 3 4.5 0.95591 -0.84597 0 0 0 5.55603 0 0 0 0 0 0 4.94542 10.6408 Q14296 FASTK_HUMAN Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8) FASTK Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; mitochondrial RNA processing [GO:0000963]; protein phosphorylation [GO:0006468]; regulation of mitochondrial mRNA stability [GO:0044528]; regulation of RNA splicing [GO:0043484] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; Fas-activated serine/threonine kinase activity [GO:0033867]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723] ARCKYSHK;LRVLLSAQTSPAR;TQDPFLPYPPR 3 6.2 0.97451 -1.3877 0 8.84765 0 8.35553 0 0 0 0 0 0 0 0 Q14315 FLNC_HUMAN Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) sarcomere organization [GO:0045214] costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802] AEGPGLNR;ASGPGLNASGIPASLPVEFTIDAR;GAGGQGQLDVR;GELTGEVRMPSGK;GVAGVPAEFSIWTR;ILVGPSEIGDASK;IQQNTFTR;IQQNTFTRWCNEHLK;LIALLEVLSQKRMYR;LLGWIQNK;LPNRHIGISFTPKEVGEHVVSVR;LVSIDSK;NDNDTFTVK;SGKHVTNSPFK;SPFEVQVSPEAGVQK;SPFVVNVAPPLDLSK;VDINCEDMEDGTCK;VFTKGAGSGELK;VNQPASFAVQLNGAR;VTGEGRMK;VTGEGRMKESITR;VVPNNDK;YGGPQHIVGSPFK 23 10.1 0 8.7197 9.85418 12.5618 10.1294 0 0 9.13247 2.56137 10.4917 10.4546 3.87293 11.5424 13.0465 Q14318 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) FKBP8 FKBP38 Homo sapiens (Human) apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; neuron fate specification [GO:0048665]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of mitophagy [GO:1901524]; smoothened signaling pathway [GO:0007224] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] MLGNPSR;SCSLVLEHQPDNIK 2 5.1 0.93237 -0.49162 0 0 0 0 0 0 0 9.96389 0 0 11.9331 0 Q14331 FRG1_HUMAN Protein FRG1 (FSHD region gene 1 protein) FRG1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; striated muscle dense body [GO:0055120]; Z disc [GO:0030018] actin filament binding [GO:0051015]; RNA binding [GO:0003723] AEYSYVKSTK 1 3.9 0.88546 -0.18224 7.00068 0 0 0 7.21101 0 0 0 0 0 0 0 Q14332 FZD2_HUMAN Frizzled-2 (Fz-2) (hFz2) (FzE2) FZD2 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling [GO:0007267]; cochlea morphogenesis [GO:0090103]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; inner ear receptor cell development [GO:0060119]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; sensory perception of smell [GO:0007608]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] LTNSRHGETTV;RPRSALPRLLLPLLLLPAAGPAQFHGEK 2 6.9 0.9097 -0.28329 0 0 0 0 0 0 0 0 0 0 5.18178 6.18267 Q14344 GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) GNA13 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] D5 dopamine receptor binding [GO:0031752]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] FLVECFRNKR;QMRIIHGQDFDQRAR;RLVKILLLGAGESGK;TDLLEEK 4 12.5 0.91689 -0.36108 10.4057 0 0 0 8.67271 0 0 0 0 0 0 10.3256 Q14376 GALE_HUMAN UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) GALE Homo sapiens (Human) galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499] cytosol [GO:0005829] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974] GGGSLPESLRR;IYNLGTGTGYSVLQMVQAMEK 2 9.2 0.90303 -0.26603 0 0 0 0 11.1891 0 0 0 0 0 0 0 Q14392 LRC32_HUMAN Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32) LRRC32 D11S833E Homo sapiens (Human) establishment of protein localization to extracellular region [GO:0035592]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; positive regulation of gene expression [GO:0010628]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] receptor ligand inhibitor activity [GO:0141069]; transforming growth factor beta binding [GO:0050431] LTRHTFR 1 1.1 0.95941 -1.0469 0 13.5657 13.7021 10.1585 0 11.2871 0 0 0 13.7762 0 0 Q14393 GAS6_HUMAN Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) GAS6 AXLLG Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; animal organ regeneration [GO:0031100]; apoptotic cell clearance [GO:0043277]; B cell chemotaxis [GO:0035754]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cell-substrate adhesion [GO:0031589]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interferon-alpha [GO:0035457]; cellular response to starvation [GO:0009267]; cellular response to vitamin K [GO:0071307]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic cell differentiation [GO:0097028]; enzyme-linked receptor protein signaling pathway [GO:0007167]; extracellular matrix assembly [GO:0085029]; fibroblast apoptotic process [GO:0044346]; fusion of virus membrane with host plasma membrane [GO:0019064]; hematopoietic stem cell migration to bone marrow [GO:0097241]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of oligodendrocyte apoptotic process [GO:1900142]; negative regulation of renal albumin absorption [GO:2000533]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; receptor-mediated virion attachment to host cell [GO:0046813]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; viral genome replication [GO:0019079] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; phosphatidylserine binding [GO:0001786]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] LKKQLVVLAVEHTALALMEIK;NLPGSYSCLCDEGFAYSSQEKACR 2 6.6 0.81509 -0.0024119 0 0 0 3.38128 0 3.77579 0 0 0 0 0 0 Q14397 GCKR_HUMAN Glucokinase regulatory protein (GKRP) (Glucokinase regulator) GCKR Homo sapiens (Human) carbohydrate derivative metabolic process [GO:1901135]; intracellular glucose homeostasis [GO:0001678]; negative regulation of glucokinase activity [GO:0033132]; protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504]; response to fructose [GO:0009750]; response to glucose [GO:0009749]; triglyceride homeostasis [GO:0070328]; urate metabolic process [GO:0046415] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] fructose-6-phosphate binding [GO:0070095]; glucose sensor activity [GO:0141089]; kinase inhibitor activity [GO:0019210] ADAENIVR;TVDQGIAASQR 2 3 0.96212 -1.0697 0 0 0 0 0 0 0 0 0 0 0 11.7623 Q14410 GLPK2_HUMAN "Glycerol kinase 2 (GK 2) (Glycerokinase 2) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 2) (Glycerol kinase, testis specific 2)" GK2 GKP2 GKTA Homo sapiens (Human) flagellated sperm motility [GO:0030317]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]; triglyceride metabolic process [GO:0006641] extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; sperm mitochondrial sheath [GO:0097226] ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370] EILQSVYECIAR;WMLDNVRNVQK 2 4.2 0.97877 -1.9189 8.1355 0 0 0 10.7341 0 0 0 0 0 0 0 Q14416 GRM2_HUMAN Metabotropic glutamate receptor 2 (mGluR2) GRM2 GPRC1B MGLUR2 Homo sapiens (Human) "behavioral response to nicotine [GO:0035095]; cellular response to stress [GO:0033554]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; glutamate secretion [GO:0014047]; intracellular glutamate homeostasis [GO:0090461]; long-term synaptic depression [GO:0060292]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of response to drug [GO:2001023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]" astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110] FGSAAAR;INRDPHLLPGVR;LFQIPQISYASTSAKLSDK;TRKCPENFNEAK 4 5.7 0.91062 -0.29449 0 0 0 0 0 0 0 0 7.82356 0 9.02475 9.83969 Q14432 PDE3A_HUMAN "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)" PDE3A Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; regulation of ribonuclease activity [GO:0060700]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; membrane [GO:0016020] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; estrogen binding [GO:0099130]; metal ion binding [GO:0046872]; nuclear estrogen receptor activity [GO:0030284]" ADPASPR 1 0.6 0.91139 -0.32419 0 0 0 0 0 0 0 0 0 0 7.40999 0 Q14435 GALT3_HUMAN Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) GALNT3 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; fibroblast growth factor receptor signaling pathway [GO:0008543]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; spermatogenesis [GO:0007283] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EIILVDDASVDEYLHDK;RKDETYPIK 2 4.1 0.78509 0.029327 0 0 0 0 0 0 0 0 8.99673 0 0 0 Q14439 GP176_HUMAN G-protein coupled receptor 176 (HB-954) GPR176 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930] SVRKCLIGTLVQLHHR;TLGNFMVLWSTCRTTVFK 2 7.2 0.9649 -1.2342 0 0 0 0 0 10.734 0 11.7235 0 0 0 0 Q14444 CAPR1_HUMAN Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 Homo sapiens (Human) generation of neurons [GO:0048699]; intracellular mRNA localization [GO:0008298]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]; synapse assembly [GO:0007416] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; membrane [GO:0016020]; P-body [GO:0000932]; synapse [GO:0045202] ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591] DGYQQNFK;GGSRGAR;SFMALSQDIQK 3 3.7 0.86994 -0.10115 8.94755 0 0 0 0 0 0 0 0 0 0 0 Q14449 GRB14_HUMAN Growth factor receptor-bound protein 14 (GRB14 adapter protein) GRB14 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971] RSGLYFSTKGTSK;VYSEDETSR 2 4.1 0.98026 -1.5729 0 0 2.10168 9.61927 0 0 0 0 0 0 0 0 Q14451 GRB7_HUMAN Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) GRB7 Homo sapiens (Human) epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of translation [GO:0017148]; positive regulation of cell migration [GO:0030335]; stress granule assembly [GO:0034063] cell projection [GO:0042995]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] SQPLLIPTTGRK 1 2.3 0.68604 0.16372 0 0 0 0 0 3.01512 0 0 0 0 0 0 Q14457 BECN1_HUMAN Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] BECN1 GT197 Homo sapiens (Human) amyloid-beta metabolic process [GO:0050435]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cellular defense response [GO:0006968]; cellular response to aluminum ion [GO:0071275]; cellular response to amino acid starvation [GO:0034198]; cellular response to copper ion [GO:0071280]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitrogen starvation [GO:0006995]; cellular response to oxygen-glucose deprivation [GO:0090650]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; engulfment of apoptotic cell [GO:0043652]; JNK cascade [GO:0007254]; late endosome to vacuole transport [GO:0045324]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of lysosome organization [GO:1905672]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron development [GO:0048666]; p38MAPK cascade [GO:0038066]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress granule assembly [GO:0062029]; protein targeting to lysosome [GO:0006622]; protein-containing complex assembly [GO:0065003]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to mitochondrial depolarisation [GO:0098780]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; SMAD protein signal transduction [GO:0060395]; suppression by virus of host autophagy [GO:0039521] "autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nuclear body [GO:0016604]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; trans-Golgi network [GO:0005802]" GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625] FCLPYRMDVEK;QDGVSRR;SVENQMRYAQTQLDK;TQFNSEEQWTK 4 9.8 0.91738 -0.40935 0 0 6.87787 0 0 10.3561 0 0 4.18998 0 0 0 Q14493 SLBP_HUMAN Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) SLBP HBP Homo sapiens (Human) cap-dependent translational initiation [GO:0002191]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA transport [GO:0051028] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone mRNA stem-loop binding complex [GO:0062073]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] histone pre-mRNA DCP binding [GO:0071208]; histone pre-mRNA stem-loop binding [GO:0071207]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] LLINDFGR 1 3 0.91371 -0.39033 0 0 0 0 0 0 11.9596 0 0 0 0 0 Q14494 NF2L1_HUMAN "Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]" NFE2L1 HBZ17 NRF1 TCF11 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cholesterol metabolic process [GO:0008203]; heme biosynthetic process [GO:0006783]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDTILNLERDVEDLQRDK;QDIDLGAGREVFDYSHR 2 4.5 0.97184 -1.3481 0 0 10.9283 0 0 0 0 0 11.4358 0 0 0 Q14498 RBM39_HUMAN RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) RBM39 HCC1 RNPC2 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" centriolar satellite [GO:0034451]; microtubule cytoskeleton [GO:0015630]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; RS domain binding [GO:0050733]; U1 snRNP binding [GO:1990446] DLEEFFSTVGK;DLEEFFSTVGKVRDVR;KDENKLSSANGHEER;TGIDLGTTGR 4 7.7 0.013861 0.81148 7.57107 0 0 0 0 0 8.98874 0 0 0 6.8813 0 Q14500 KCJ12_HUMAN "ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)" KCNJ12 IRK2 KCNJN1 Homo sapiens (Human) muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; T-tubule [GO:0030315] inward rectifier potassium channel activity [GO:0005242] TYEVPSTPR 1 2.1 0.93024 -0.48003 0 0 0 9.58509 0 0 0 0 0 0 0 0 Q14508 WFDC2_HUMAN WAP four-disulfide core domain protein 2 (Epididymal secretory protein E4) (Major epididymis-specific protein E4) (Putative protease inhibitor WAP5) WFDC2 HE4 WAP5 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] aspartic-type endopeptidase inhibitor activity [GO:0019828]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] CCSAGCATFCSLPNDK 1 12.9 0.6451 0.17151 0 0 0 0 4.5612 0 0 0 0 0 0 0 Q14511 CASL_HUMAN Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] NEDD9 CASL Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cilium disassembly [GO:0061523]; cytoskeleton organization [GO:0007010]; integrin-mediated signaling pathway [GO:0007229]; learning or memory [GO:0007611]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of cell migration [GO:0030336]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of lymphocyte chemotaxis [GO:0140131]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein localization [GO:1903829]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165] basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922] protein tyrosine kinase binding [GO:1990782] ALPPGLSK;DEAGLREK;GVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAK 3 6.1 0.93557 -0.52796 0 0 0 0 0 0 0 0 9.06223 11.3281 0 0 Q14512 FGFP1_HUMAN Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17) FGFBP1 FGFBP HBP17 Homo sapiens (Human) cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast proliferation [GO:0051450]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of myoblast proliferation [GO:2000288]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201] DTLGNTQIK;ETTPSSLAVTQTMATK;NLRSQKDICR;TEMSPREHIK 4 19.2 0.98006 -1.8289 0 3.57737 0 0 8.29724 0 0 0 10.7679 0 11.9803 0 Q14515 SPRL1_HUMAN SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) SPARCL1 Homo sapiens (Human) regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840] EEDIDENLLF;ETAVSTEDDSHHK;NHGVDDDGDDDGDDGGTDGPR 3 6.6 0.90879 -0.30207 0 8.11816 0 6.68552 0 0 0 0 0 0 0 0 Q14517 FAT1_HUMAN "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754] apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALEKNTNVEAR;DGEIRYSIR;HGRSPQVGNGFR;ILDENDNKPQFLQKFYK;ILSPLDR;LTENENK;LVLDQVHTASGTAPGTLK;QQAAHFELEVTTSDR;RFSAAGEYDILSIKAVDNGRPQK;TGLITTTSRKLDR;VIDTNDHRPQFSTSK 11 3.2 0.97677 -4.9336 0 10.7486 0 0 10.4097 6.11564 0 0 11.7387 8.39797 10.9176 0 Q14520 HABP2_HUMAN Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form] HABP2 HGFAL PHBP Homo sapiens (Human) cell adhesion [GO:0007155]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GKFCEIGSDDCYVGDGYSYR;LPGFDSCGKTEIAERK;NPDADEKPWCFIK 3 8.8 0.84742 -0.069396 0 0 3.3512 0 0 0 9.3605 0 3.65753 0 0 0 Q14524 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) SCN5A Homo sapiens (Human) atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; cardiac conduction system development [GO:0003161]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005] caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; nitric-oxide synthase binding [GO:0050998]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060]; voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063] ISYEPITTTLRR;KLGSKKPQKPIPRPLNK;LAQRYLIWECCPLWMSIK;TLRALRPLRALSR 4 3 0.93546 -0.52929 11.773 0 0 0 0 0 0 0 0 0 0 9.83968 Q14525 KT33B_HUMAN "Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)" KRT33B HHA3-II HKA3B KRTHA3B Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; hair cycle [GO:0042633]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] CGPCNTFGY;LAADDFR 2 4 0.67242 0.1678 0 0 10.1366 0 0 0 0 0 0 10.2292 0 5.20735 Q14527 HLTF_HUMAN Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of neurogenesis [GO:0050767] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" AVLDLESER;LDGSMAQK;QAKINEIR;VFIQHITLSDEERK;VNNVNGNQVGHLK 5 5.2 0.97578 -2.3305 0 9.91433 6.74819 9.57945 0 0 0 0 0 9.31016 0 0 Q14534 ERG1_HUMAN Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE) SQLE ERG1 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; lipid droplet formation [GO:0140042]; regulation of cell population proliferation [GO:0042127]; response to biphenyl [GO:1904614]; sterol biosynthetic process [GO:0016126] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] FAD binding [GO:0071949]; squalene monooxygenase activity [GO:0004506] KACFLYFK 1 1.4 0.83992 -0.043952 0 0 0 0 0 0 0 0 0 9.95636 0 0 Q14541 HNF4G_HUMAN Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2) HNF4G NR2A2 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" EAVQNER;IASIGDVCESMK;NTTDNGVNCLCAICGDRATGK;QCVVDKDK 4 11.8 0.9742 -2.4332 8.22149 0 0 8.40126 0 0 0 8.68506 0 10.6177 10.2641 0 Q14542 S29A2_HUMAN "Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)" SLC29A2 DER12 ENT2 HNP36 Homo sapiens (Human) adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; guanine transmembrane transport [GO:1903716]; guanine transport [GO:0015854]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213] ILGSLLAILLLFALTAALVK 1 4.4 0.64202 0.17351 0 6.66107 0 0 0 0 0 0 0 0 0 0 Q14549 GBX1_HUMAN Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1) GBX1 Homo sapiens (Human) adult walking behavior [GO:0007628]; neuron fate commitment [GO:0048663]; proprioception [GO:0019230]; regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory neuron axon guidance [GO:0097374]; spinal cord motor neuron differentiation [GO:0021522] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" NPKIVVPIPVHVNRFAVR 1 5 0.8658 -0.08892 0 0 0 0 0 0 0 0 0 0 4.42378 0 Q14554 PDIA5_HUMAN Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) PDIA5 PDIR Homo sapiens (Human) electron transport chain [GO:0022900]; protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] oxidoreductase activity [GO:0016491]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] DFRRLLK;ISDPKDLK;SIVAFLKDPK 3 4.8 0.97259 -2.7741 12.5321 0 0 0 0 0 0 0 0 0 0 0 Q14558 KPRA_HUMAN Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) PRPSAP1 Homo sapiens (Human) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737] enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] AQSYAERLR;NAARTGYRVFSANSTAACTELAK 2 9 0.96608 -1.2841 0 0 0 0 0 0 0 0 0 5.92417 0 10.9393 Q14562 DHX8_HUMAN ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) DHX8 DDX8 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]" DKQALADQKK;KHAFGGNKASYGK;LEPLYNR;QALADQKK;QMLGIMDR 5 3.1 0.97482 -3.1951 0 0 9.15145 0 0 0 0 0 0 0 0 12.6493 Q14563 SEM3A_HUMAN Semaphorin-3A (Semaphorin III) (Sema III) SEMA3A SEMAD Homo sapiens (Human) axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; regulation of axon extension involved in axon guidance [GO:0048841]; semaphorin-plexin signaling pathway [GO:0071526]; sensory system development [GO:0048880]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] ALVYWQFQR;ALVYWQFQRR;IVWPVSYTRRDECK;NDFGGHR;TLGHHHPIRTEQHDSR 5 6.1 0.98024 -2.0083 0 12.2684 0 0 0 0 8.68148 0 0 0 4.79821 10.4694 Q14566 MCM6_HUMAN DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) MCM6 Homo sapiens (Human) DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] AVYTSGK;DVEQQFK;ESEDFIVEQYK;GDINVCIVGDPSTAK;IEESIDR;IQETQAELPR;ISGQVVR;ISNLIVLHLRK;LGFSEYCRISNLIVLHLR;LSEAMAR;LSTPGAR;LVFLACCVAPTNPR;QFKPKISKESEDFIVEQYK;SELVNWYLK;TTGEGTSLR;VSGVDGYETEGIR;YTQPNICR 17 19.2 0 3.6621 11.8377 9.33584 3.31696 11.3184 10.102 9.47539 0 12.1682 11.701 12.1032 10.7737 0 Q14568 HS902_HUMAN Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 Homo sapiens (Human) cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] ADLINNLGTIAK;ELISNSSDALDK;EVSDDETEEK;TKPIWTR;YIDQEELNK 5 14.6 0.89671 -0.23612 0 0 0 0 0 0 9.02381 0 0 0 0 0 Q14571 ITPR2_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)" ITPR2 Homo sapiens (Human) cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165] cell cortex [GO:0005938]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]" CVVHPEAGDLANPPK;EIYTSNHIWK;ELQNFLRNQNNK;ILFNMRPR;KNQEYIAK;LSKLCVQNK;LTVEKSELWVEK;NAYNQGLECDHGDDEGGDDGVSPK;NLDWFPRMR;NLIYFGFYSFSELLR;NQHQRLLK;TLAEVAKNR 12 5.1 0.97842 -7.3614 0 0 0 0 10.3588 9.8015 0 12.6281 10.7356 0 9.32067 0 Q14573 ITPR3_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" ITPR3 Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; G protein-coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of taste [GO:0050909]; sensory perception of umami taste [GO:0050917] apical part of cell [GO:0045177]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; inositol hexakisphosphate binding [GO:0000822]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]" AFPRVTPTANQWDYK;EIYTSNHIWTLFENFTLDMAR;FFKVLHDR;LMREQNILK;NLDWFPRMR;TDSFVPR;VLRHSQEDYR 7 3 0.97329 -2.4866 0 5.85255 9.04051 10.1098 0 0 0 7.43679 0 6.48675 0 0 Q14574 DSC3_HUMAN Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) DSC3 CDHF3 DSC4 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; protein stabilization [GO:0050821] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295] LHDPKGWITIDEISGSIITSKILDR;LLRVNLCECTHPTQCRATSR;QEEDGLDFLNNLEPK;SPGLFSVHPSTGVITTVSHYLDR;STGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGK;VCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMK 6 18 0.97489 -1.3846 0 0 9.46618 10.5094 10.8507 4.98085 0 7.88056 8.79015 0 6.78241 0 Q14585 ZN345_HUMAN Zinc finger protein 345 (Zinc finger protein HZF10) ZNF345 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AFGSGSK;SFSFESALIRHHR 2 4.1 0.96114 -1.0595 11.7093 0 0 0 7.20271 0 0 0 0 7.56377 9.90244 0 Q14586 ZN267_HUMAN Zinc finger protein 267 (Zinc finger protein HZF2) ZNF267 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CVEVCTQSLKHIQHQTIHIRENSYSYNK;QIIHNEEKPYKCEK 2 5.7 0.93635 -0.54875 0 0 0 10.2174 0 0 0 0 0 11.2904 0 10.5244 Q14587 ZN268_HUMAN Zinc finger protein 268 (Zinc finger protein HZF3) ZNF268 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKPYECSECGK;IDDLMDWHQENK;IHTGENPYECSECGK;IRKLQGQESILGQGTPGLQPLPGTPR;SLKYIDFTSDYAR 5 8.1 0.97631 -2.2516 0 0 11.3229 9.75412 0 0 0 0 0 9.80861 10.5639 0 Q14587 ZN268_HUMAN Zinc finger protein 268 (Zinc finger protein HZF3) ZNF268 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDDLMDWHQENK;SLKYIDFTSDYAR;VQAQVPNQTCPNTVWK 3 50.6 0.78433 0.029886 0 0 0 0 0 0 0 0 0 0 10.7211 0 Q14588 ZN234_HUMAN Zinc finger protein 234 (Zinc finger protein 269) (Zinc finger protein HZF4) ZNF234 ZNF269 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] AGLYTTHTGQK;IHQRVHTGEKPYKCEECGK;KGKSADK 3 5.3 0.39877 0.21027 11.203 0 14.0262 0 0 0 0 5.39917 0 0 6.49198 0 Q14590 ZN235_HUMAN Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] QTQMKNK;YWCHECGK 2 2 0.97925 -1.8799 0 0 0 0 0 0 0 0 0 0 8.17343 0 Q14592 ZN460_HUMAN Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8) ZNF460 ZNF272 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CLECGKDFNR 1 1.8 0.92426 -0.44949 0 0 0 0 0 0 3.75232 0 0 0 0 0 Q14596 NBR1_HUMAN Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872] autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; M band [GO:0031430]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; phagophore assembly site [GO:0000407]; receptor complex [GO:0043235] mitogen-activated protein kinase binding [GO:0051019]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] YSTPRLPAALEQVRLQK 1 1.8 0.49744 0.1892 0 0 0 0 0 0 0 9.61872 0 0 0 0 Q14623 IHH_HUMAN Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product] IHH Homo sapiens (Human) bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye photoreceptor cell fate commitment [GO:0060220]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell-cell signaling [GO:0007267]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte proliferation [GO:0035988]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint development [GO:0072498]; epithelial cell morphogenesis [GO:0003382]; epithelial cell-cell adhesion [GO:0090136]; head morphogenesis [GO:0060323]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; intein-mediated protein splicing [GO:0016539]; liver regeneration [GO:0097421]; maternal process involved in female pregnancy [GO:0060135]; multicellular organism growth [GO:0035264]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of eye pigmentation [GO:0048074]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell differentiation in thymus [GO:0033085]; neuron development [GO:0048666]; osteoblast differentiation [GO:0001649]; pancreas development [GO:0031016]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; regulation of growth [GO:0040008]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; retinal pigment epithelium development [GO:0003406]; self proteolysis [GO:0097264]; skeletal system development [GO:0001501]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; vitelline membrane formation [GO:0030704] endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; patched binding [GO:0005113]; peptidase activity [GO:0008233] LNSLAISVMNQWPGVK;TLGASGR;VAAVSTHVALGAYAPLTK 3 10 0.86936 -0.094991 0 0 0 0 0 0 0 0 11.1891 10.9508 0 0 Q14624 ITIH4_HUMAN Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; response to cytokine [GO:0034097] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet dense granule lumen [GO:0031089] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] NRRSSAYK;TKAHIRFKPTLSQQQK 2 2.6 0.96728 -1.3183 0 0 0 0 6.07273 0 6.88203 0 0 9.47828 0 0 Q14627 I13R2_HUMAN Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2) IL13RA2 IL13R Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of mast cell degranulation [GO:0043305]; positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] DFYICVNGSSENKPIR;TTNETRQLCFVVRSK 2 8.2 0.74506 0.096332 0 10.9599 0 0 0 0 0 0 0 0 7.8062 0 Q14642 I5P1_HUMAN "Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)" INPP5A 5PTASE Homo sapiens (Human) inositol phosphate metabolic process [GO:0043647]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; phosphatidylinositol dephosphorylation [GO:0046856] dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; PH domain binding [GO:0042731]" LDSKSVVETLCTKATMQTVR 1 4.9 0.44455 0.19315 0 0 0 0 0 0 8.12443 0 0 0 0 0 Q14643 ITPR1_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) "calcium import into the mitochondrion [GO:0036444]; calcium ion transport [GO:0006816]; cell morphogenesis [GO:0000902]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of calcium-mediated signaling [GO:0050849]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin secretion [GO:0032024]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; regulation of autophagy [GO:0010506]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; voluntary musculoskeletal movement [GO:0050882]" calcineurin complex [GO:0005955]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; platelet dense tubular network [GO:0031094]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum [GO:0016529]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "ATP binding [GO:0005524]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels [GO:0098695]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]" HICRLCYR;ILYNMRPKELVEVIKK;KNQEYIAK;LDYRISCLLCIFK;LMREQNILK;NLDWFPRMR;QIKQDLDQLR;SIVEKSELWVYK;SSNVMRSIHGVGELMTQVVLR;VLSDVAK 10 4.1 0.97511 -2.3532 9.37267 10.7818 0 10.8738 0 0 8.37125 9.50108 9.25981 0 0 0 Q14644 RASA3_HUMAN Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) RASA3 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; platelet activation [GO:0030168]; signal transduction [GO:0007165] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] calcium channel regulator activity [GO:0005246]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] KTKYGSQEHPIGDK;NLPSYPGPSK;YTAVSSFIFLR 3 4.2 0.91054 -0.29292 0 0 7.42962 0 0 0 9.97656 0 7.90749 9.21162 0 0 Q14651 PLSI_HUMAN Plastin-1 (Intestine-specific plastin) (I-plastin) PLS1 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200] EIVEKILSVADSNK;ENLSDEDKLNNAK;IYALPDDLVEVKPK;LSPEELLLR;QFVTPADVVSGNPK 5 10.2 0.91136 -0.32549 0 10.1236 0 0 0 0 10.6311 0 0 0 0 0 Q14653 IRF3_HUMAN Interferon regulatory factor 3 (IRF-3) IRF3 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cGAS/STING signaling pathway [GO:0140896]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage apoptotic process [GO:0071888]; MDA-5 signaling pathway [GO:0039530]; mRNA transcription [GO:0009299]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; programmed necrotic cell death [GO:0097300]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction involved in regulation of gene expression [GO:0023019]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GVMSYVR;LVGSEVGDR;LVMVKVVPTCLR 3 6.6 0.97647 -1.489 0 0 0 0 0 0 0 0 9.70608 13.6732 0 0 Q14654 KCJ11_HUMAN "ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)" KCNJ11 Homo sapiens (Human) action potential [GO:0001508]; apoptotic process [GO:0006915]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to glucose stimulus [GO:0071333]; cellular response to nicotine [GO:0071316]; cellular response to nutrient levels [GO:0031669]; cellular response to tumor necrosis factor [GO:0071356]; determination of adult lifespan [GO:0008340]; glucose metabolic process [GO:0006006]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of insulin secretion [GO:0046676]; nervous system process [GO:0050877]; positive regulation of protein localization to plasma membrane [GO:1903078]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to resveratrol [GO:1904638]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; ventricular cardiac muscle tissue development [GO:0003229] acrosomal vesicle [GO:0001669]; axolemma [GO:0030673]; cell body fiber [GO:0070852]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; inward rectifying potassium channel [GO:0008282]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; T-tubule [GO:0030315] ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; heat shock protein binding [GO:0031072]; potassium ion binding [GO:0030955]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] VPTPLCTAR 1 2.3 0.91836 -0.40428 0 0 0 0 0 0 0 0 0 10.933 0 0 Q14667 BLTP2_HUMAN Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) BLTP2 BCOX1 KIAA0100 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] DFQLQRANKMELR;GVPTSASAPPR;IISRCNCR;LLIGLSVGDK;LLIGLSVGDKNPGK;LQLQLNQEK;MELRKQQEDVSVVR;NIEEHRQR;NIEIYIQR;RKEHSEK;SPEHPVDDIDKMKER 11 4.6 0.97506 -3.9936 4.84323 16.5272 0 10.2969 0 5.44477 5.25395 4.95285 0 10.9333 0 10.5119 Q14669 TRIPC_HUMAN E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) TRIP12 KIAA0045 ULF Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630] AQTAPTKTSPR;CLRAILR;DDDKVDNQAK;DNSRGVK;GAAEARR;GRAQTAPTKTSPR;LPDIFSVYFRREGVMHQVK;LPVGGFRSLNPPLTIVRK;RSRSASSPSPR;TVNREELLK 10 5.1 0.97749 -5.9347 11.8734 5.80908 0 8.26228 8.45241 0 0 11.3531 10.1333 10.9331 8.37877 0 Q14671 PUM1_HUMAN Pumilio homolog 1 (HsPUM) (Pumilio-1) PUM1 KIAA0099 PUMH1 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] DQYANYVVQK;GIFLGDQWR;RKAVLWQDSFSPHLK;YISAAPGAEAKYR 4 4 0.89483 -0.2429 10.1141 0 8.02547 0 0 0 0 0 0 0 0 0 Q14674 ESPL1_HUMAN Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) ESPL1 ESP1 KIAA0165 Homo sapiens (Human) apoptotic process [GO:0006915]; establishment of mitotic spindle localization [GO:0040001]; homologous chromosome segregation [GO:0045143]; meiotic chromosome separation [GO:0051307]; meiotic spindle organization [GO:0000212]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; mitotic sister chromatid separation [GO:0051306]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteolysis [GO:0006508] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] catalytic activity [GO:0003824]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] GVSLLLSVLR;GVSLLLSVLRDPALQK;HVIRALVGER;KKLPSPCPDK;LEKDSPPVSVQIPTGQNK 5 2.5 0.97357 -2.6482 0 0 9.42545 0 0 0 0 0 11.1939 9.77266 0 0 Q14676 MDC1_HUMAN Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein localization to site of double-strand break [GO:1990166] chromosome [GO:0005694]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463]; histone reader activity [GO:0140566] GPLERETEK;HLAPPPLLSPLLPSIKPTVRK;LNQESTAPK;QLLARDTQR 4 2.3 0.95443 -0.90872 0 0 0 0 0 0 3.67525 11.0701 12.3489 0 0 0 Q14677 EPN4_HUMAN Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) CLINT1 ENTH EPN4 EPNR KIAA0171 Homo sapiens (Human) clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897] clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] DQGINIRQK;DQGINIRQKVK;IGSTIDDTISK;SLENYHFVDEHGK 4 5.6 0.9746 -3.4884 0 0 0 9.578 0 11.1618 7.08162 0 0 0 0 0 Q14679 TTLL4_HUMAN Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) TTLL4 KIAA0173 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222] 9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" EIRFTEAVR;IKDVVVKTIISSEPYVTSLLK;NLSRMQSR 3 3.2 0.98122 -1.7076 0 12.2567 0 0 0 0 0 0 5.20906 0 0 0 Q14683 SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1 Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]; somatic stem cell population maintenance [GO:0035019] "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; mediator complex binding [GO:0036033]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] AATLAQELEK;ELNQVMEQLGDARIDR;IEKLEEYITTSK;LEFENQK;LIDLCQPTQK;LIEIENFK;LYPGSVYGR;QAFEQIK;QEKEEADRYQR;SLQNAQKHYK;TALFEEISR 11 8.8 0.97483 -3.2769 0 10.7019 12.0269 0 0 0 12.6508 11.413 9.63494 10.1431 0 8.82359 Q14684 RRP1B_HUMAN Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) RRP1B KIAA0179 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; mRNA processing [GO:0006397]; negative regulation of GTPase activity [GO:0034260]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] "chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] LLEMTSRK;RNGWEESRIK;VGGKELLADQNLK 3 4.1 0.95245 -0.68287 0 0 0 0 0 0 0 0 0 0 9.53243 7.09793 Q14686 NCOA6_HUMAN "Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)" NCOA6 AIB3 KIAA0181 RAP250 TRBP Homo sapiens (Human) brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; intracellular membrane-bounded organelle [GO:0043231]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713] AIGQAPSNLTMNPSNFATPQTHK;NVPNLLHMESSKLK;SLQGGPSRVPTPLQQPHLTNK;SSPGSSR;TEEPTVASESVENGHRKR 5 4 0.96456 -1.1522 7.46426 0 0 9.80678 8.76261 0 0 0 11.6907 0 0 10.1685 Q14687 GSE1_HUMAN Genetic suppressor element 1 GSE1 KIAA0182 Homo sapiens (Human) EREREADR;SLSMLHYIR;TVNGVWR 3 2 0.97264 -2.6665 12.9099 0 0 0 0 0 0 0 0 0 0 0 Q14689 DIP2A_HUMAN Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) DIP2A C21orf106 DIP2 KIAA0184 Homo sapiens (Human) acetyl-CoA biosynthetic process [GO:0006085]; dendritic spine morphogenesis [GO:0060997]; negative regulation of gene expression [GO:0010629]; positive regulation of peptidyl-lysine acetylation [GO:2000758] cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] acetate-CoA ligase activity [GO:0003987] AVLSMNGLSYGVIR;EAAAAVDIR;IAQASGRELAHLEDSDQAR;IQQLLNTLKRPKRPPLK;VSSKIQQLLNTLKRPK 5 4 0.89767 -0.23396 0 3.83905 0 13.1985 13.0453 12.7969 13.9482 13.5982 13.7415 0 0 14.0029 Q14690 RRP5_HUMAN Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) PDCD11 KIAA0185 Homo sapiens (Human) rRNA processing [GO:0006364] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723] AGLSEEDDSLVDVYYREGK;ALEYVEAK;AVQYNEPLK;ESSKSAREK;FFFKRYLDYEK;IPLLLTSLSFKVLK;SAREKFEILSVESLCEGMR;TSIIEAQYLR;VLRLNHQK;YLPISHPRFVR 10 6 0.97822 -6.8806 17.2709 0 17.1747 0 0 11.5361 0 0 0 10.1147 11.9318 0 Q14691 PSF1_HUMAN DNA replication complex GINS protein PSF1 (GINS complex subunit 1) GINS1 KIAA0186 PSF1 Homo sapiens (Human) DNA strand elongation involved in mitotic DNA replication [GO:1902983]; DNA unwinding involved in DNA replication [GO:0006268]; inner cell mass cell proliferation [GO:0001833] CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NSQHFLPRWK;SLYIEVR 2 8.7 0.93381 -0.5055 0 0 0 0 0 0 0 0 0 7.29517 7.75221 0 Q14692 BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) BMS1 BMS1L KIAA0187 Homo sapiens (Human) "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] AAGEGSK;IAATGVVLDLDKSIKIVK;RLLQDLQLGDEEDAR;RRPAVIR;SSAEEGEAEEADESSEEEDCTAGEK 5 5.6 0.26856 0.25875 3.21853 9.9256 8.96878 4.43749 8.49833 6.65621 0 0 0 0 0 9.52499 Q14693 LPIN1_HUMAN Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) LPIN1 KIAA0188 Homo sapiens (Human) animal organ regeneration [GO:0031100]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of myelination [GO:0031642]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylethanolamine metabolic process [GO:0046337]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]; triglyceride mobilization [GO:0006642] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] EKVVDIEINGESVDLHMK;TDSPSRKR 2 2.9 0.964 -1.2021 0 0 0 0 0 0 0 0 0 0 0 7.62366 Q14694 UBP10_HUMAN Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) USP10 KIAA0190 Homo sapiens (Human) "autophagy [GO:0006914]; cellular response to interleukin-1 [GO:0071347]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of stress granule assembly [GO:0062030]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of protein stability [GO:0031647]; rescue of stalled ribosome [GO:0072344]; translesion synthesis [GO:0019985]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; early endosome [GO:0005769]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; molecular function inhibitor activity [GO:0140678]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] IVRDIRPGAAFEPTYIYRLLTVNK;NIEYPVDLEISK;VTLEKLPPVLVLHLK 3 6.4 0.93227 -0.49201 0 0 0 0 0 0 0 5.02959 0 0 10.691 8.21578 Q14697 GANAB_HUMAN Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB G2AN KIAA0088 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020] "alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; Glc2Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0106407]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; RNA binding [GO:0003723]" AFFAGSQR;DPAEGDGAQPEETPR;IDELEPR;LDLLEDR;NPEPELLVR;VNLTLGSIWDKIKNLFSR;VPDVLVADPPIAR;VTEGGEPYR;VVIIGAGKPAAVVLQTK;YRVPDVLVADPPIAR 10 10.9 0 3.7403 0 12.2474 0 8.22598 9.20565 9.71517 12.2569 11.7893 11.5093 10.6042 10.772 0 Q14703 MBTP1_HUMAN Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1) MBTPS1 KIAA0091 S1P SKI1 Homo sapiens (Human) ATF6-mediated unfolded protein response [GO:0036500]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein import into nucleus [GO:0006606]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of vesicle-mediated transport [GO:0060627]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] serine-type endopeptidase activity [GO:0004252] ELVNPASMK;HQKLLSIDLDKVVLPNFR;MKLVNIWLLLLVVLLCGKK;MKPDIVTYGAGVRGSGVKGGCR;VLWDQYHNLR;VLWDQYHNLRYPPGYFPR 6 8.2 0.91949 -0.4377 0 0 0 0 8.809 5.83249 10.7548 0 5.31441 11.6382 5.0505 0 Q14714 SSPN_HUMAN Sarcospan (K-ras oncogene-associated protein) (Kirsten-ras-associated protein) SSPN KRAG Homo sapiens (Human) cell adhesion [GO:0007155]; muscle contraction [GO:0006936] dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133] ECGEEEPRTCCGCR 1 5.8 0.833 -0.028396 0 0 0 0 0 0 0 0 0 0 0 4.54251 Q14721 KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) KCNB1 Homo sapiens (Human) action potential [GO:0001508]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; clustering of voltage-gated potassium channels [GO:0045163]; glucose homeostasis [GO:0042593]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of insulin secretion [GO:0046676]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of protein targeting to membrane [GO:0090314]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of action potential [GO:0098900]; regulation of motor neuron apoptotic process [GO:2000671]; response to axon injury [GO:0048678]; response to L-glutamate [GO:1902065]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; proximal dendrite [GO:1990635]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; transmembrane transporter binding [GO:0044325] AKRNGSIVSMNMK;GPSGQEK;HSTGLQSLGFTLR;PAGMTKHGSR;SSSSPQHLNVQQLEDMYNKMAK 5 7.6 0.96309 -1.0905 0 0 0 8.82308 0 0 6.71905 0 6.48015 5.78125 6.0205 10.5089 Q14722 KCAB1_HUMAN Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) KCNAB1 KCNA1B Homo sapiens (Human) negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion transport [GO:0006813]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of potassium ion transmembrane transport [GO:1901379] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076] aldo-keto reductase (NADPH) activity [GO:0004033]; carbonyl reductase (NADPH) activity [GO:0004090]; molecular function inhibitor activity [GO:0140678]; NADPH binding [GO:0070402]; potassium channel regulator activity [GO:0015459]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] IVSEEGRK;MHLYKPACADIPSPK 2 5.6 0.91549 -0.37111 0 3.95475 0 0 0 0 12.0905 0 0 0 0 0 Q14728 MFS10_HUMAN Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) MFSD10 TETRAN Homo sapiens (Human) apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252] brush border membrane [GO:0031526]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637] organic anion transmembrane transporter activity [GO:0008514]; tetracycline transmembrane transporter activity [GO:0008493] APSIALGFR;RALLLLVPAFLLIGWGR 2 5.7 0.91722 -0.42189 0 0 0 0 7.19081 0 0 0 0 5.33899 0 0 Q14739 LBR_HUMAN Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) LBR Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; neutrophil differentiation [GO:0030223]; random inactivation of X chromosome [GO:0060816] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear lamina [GO:0005652]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; delta14-sterol reductase activity [GO:0050613]; DNA binding [GO:0003677]; lamin binding [GO:0005521]; NADPH binding [GO:0070402]; RNA binding [GO:0003723] KNPSDPKLAHLK;LTPLILKPFGNSISR;VVEGTPLIDGR;VVEGTPLIDGRR;YNGEPEHIERNDAPHKNTQEK 5 9.8 0.97237 -2.7865 3.69421 0 7.99611 0 9.63505 0 0 0 0 0 0 10.7864 Q14746 COG2_HUMAN Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) COG2 LDLC Homo sapiens (Human) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] protein-containing complex binding [GO:0044877] AHPAYHSFNK;EEVLSLRSSVSEGIRAVDER;KMCVLRLIQVIR;LEMIGFK;TYATIDK 5 7.6 0.96567 -1.1452 0 0 0 0 0 4.84197 11.2032 0 0 0 0 0 Q14749 GNMT_HUMAN Glycine N-methyltransferase (EC 2.1.1.20) GNMT Homo sapiens (Human) glycogen metabolic process [GO:0005977]; methionine metabolic process [GO:0006555]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein modification process [GO:0036211]; regulation of gluconeogenesis [GO:0006111]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethionine metabolic process [GO:0046500]; sarcosine metabolic process [GO:1901052] cytosol [GO:0005829] folic acid binding [GO:0005542]; glycine binding [GO:0016594]; glycine N-methyltransferase activity [GO:0017174]; identical protein binding [GO:0042802]; S-adenosyl-L-methionine binding [GO:1904047] LSYYPHCLASFTELLQAAFGGK;MLKYALKER 2 10.5 0.81615 -0.002816 0 11.6571 0 0 7.95367 7.52654 0 0 0 0 0 0 Q14764 MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein) MVP LRP Homo sapiens (Human) cell population proliferation [GO:0008283]; ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; protein activation cascade [GO:0072376]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903] ELPPGVEELLNK;GQDPLADR;NSARIIR;QMTEAIGPSTIR;VLFAPMRMVTVPPR 5 5.9 0.97834 -1.9375 0 0 0 0 7.5352 9.6209 0 0 0 11.1847 5.90005 10.6304 Q14765 STAT4_HUMAN Signal transducer and activator of transcription 4 STAT4 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741]; response to peptide hormone [GO:0043434]; T-helper 1 cell differentiation [GO:0045063] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LLIKLPELNYQVKVK;LTVQSSYSDGHLTWAKFCKEHLPGK;TLIQFTVKLRLLIK;YLYPDIPK 4 7.8 0.97352 -1.4105 0 0 0 0 0 0 0 0 0 0 11.1795 11.1973 Q14766 LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) LTBP1 Homo sapiens (Human) establishment of protein localization to extracellular region [GO:0035592]; sequestering of TGFbeta in extracellular matrix [GO:0035583] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; microfibril binding [GO:0050436]; molecular adaptor activity [GO:0060090]; receptor ligand inhibitor activity [GO:0141069]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024] CEYCDSGYR;CQKCPKKPSYHGYNQMMECLPGYK;GDCINTAGSYDCTCPDGFQLDDNK;NTEGSFRCTCGQGYQLSAAK;QQLQGVNVCGGR;VVICHLPCMNGGQCSSR 6 6.2 0.96605 -1.1254 3.82751 0 0 10.7515 5.93687 10.3782 0 0 11.1147 5.62152 11.2257 12.6517 Q14767 LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2 (LTBP-2) LTBP2 C14orf141 LTBP3 Homo sapiens (Human) protein secretion [GO:0009306]; protein targeting [GO:0006605]; supramolecular fiber organization [GO:0097435]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; microfibril binding [GO:0050436] AQPGWGSPR;CSCEQGYEVTSDEKGCQDVDECASR;SGAAPPTPPRGR;SSGALPGPAERQPLR;VGKAWGSECEK 5 4 0.97474 -3.8602 0 0 0 8.42227 6.39647 0 0 6.16416 0 0 9.58798 0 Q14773 ICAM4_HUMAN Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242) ICAM4 LW Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] integrin binding [GO:0005178] FHRCPCRDPPHCGR;GPGWVSYQLLDVR 2 9.9 0.98065 -1.613 0 0 0 0 0 0 0 0 0 0 0 11.1196 Q14774 HLX_HUMAN H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) HLX HLX1 Homo sapiens (Human) embryonic digestive tract morphogenesis [GO:0048557]; enteric nervous system development [GO:0048484]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; organ growth [GO:0035265]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of organ growth [GO:0046622]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" HSKEAQAQKDK 1 2.3 0.97582 -1.4607 0 0 0 0 0 0 0 0 0 0 14.4536 0 Q14781 CBX2_HUMAN Chromobox protein homolog 2 CBX2 Homo sapiens (Human) cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; development of primary sexual characteristics [GO:0045137]; negative regulation of transcription by RNA polymerase II [GO:0000122] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064] AQATNKCGLGLDLK;GKLEYLVK 2 4.1 0.98075 -1.8002 0 12.1112 0 0 0 0 0 0 0 0 0 0 Q14789 GOGB1_HUMAN Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) GOLGB1 Homo sapiens (Human) Golgi organization [GO:0007030]; protein localization to pericentriolar material [GO:1905793]; regulation of DNA-templated transcription [GO:0006355] cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] AVDKTNQLMETLK;DLVEMEQKLLMVTK;ELAQLKEQGLLNRER;ELQSNKESVK;ELRSSSSQTQPLK;ELSMVTELRAQVK;LALEGLTEDKEK;LITEMDR;LKETAEEEK;LLEEERDQR;LNQQLLSK;LQAALINRKELLQR;QKNKEFSQTLENEK;SFNALQEEK;SLQSQLQNK;TKVESEIRK;VEELSQALSQK;VVELENEK;YSALEQKHKAEMEEK 19 6.5 0.97878 -11.02 9.00868 12.6767 9.46467 10.8912 10.4402 7.76593 11.9603 13.046 13.5645 12.7965 18.4711 12.7917 Q14790 CASP8_HUMAN Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) activation of cysteine-type endopeptidase activity [GO:0097202]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptotic inflammatory response [GO:0070269]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462] CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625] LGDSETAMVPGK;VILGEGK;VMLYQISEEVSR 3 5.8 0.93659 -0.52592 0 0 0 0 0 0 0 0 0 0 11.9629 0 Q147U1 ZN846_HUMAN Zinc finger protein 846 ZNF846 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ACECKECGK;ACGKAFTRSSGLVLHMR;DVMLENYK;KSHAEGK;RSLMSGLEQMEELR;THTGAKPYECKK 6 12.6 0.98016 -1.7153 0 0 0 0 0 0 10.8471 0 7.35244 10.6355 10.5645 9.78989 Q147X3 NAA30_HUMAN N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) NAA30 C14orf35 MAK3 NAT12 Homo sapiens (Human) protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleus [GO:0005634] peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-methionine-alpha-N-acetyltransferase activity [GO:0120518] EVEPGEDRTIR;EVEPGEDRTIRYVR 2 3.9 0.98079 -1.6741 0 0 10.5102 0 0 0 0 0 0 0 0 10.0122 Q14802 FXYD3_HUMAN FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) FXYD3 MAT8 PLML Homo sapiens (Human) chloride transport [GO:0006821]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080] GGLEEPLER 1 6.2 0.88058 -0.16959 0 0 0 0 0 0 0 0 0 10.6353 0 0 Q14807 KIF22_HUMAN Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) KIF22 KID KNSL4 Homo sapiens (Human) DNA repair [GO:0006281]; metaphase chromosome alignment [GO:0051310]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DLEIERLK;LSQKELLGPPEAK;MDSCSLEIANWR;TGNKGLR;TVEEKDLEIER;VEGITGK;VLDLLDPASGDLVIR;YQFDAFYGERSTQQDIYAGSVQPILR 8 15.6 0.97824 -6.3754 0 0 0 0 0 0 10.0604 10.244 4.75451 10.6692 3.21929 0 Q14814 MEF2D_HUMAN Myocyte-specific enhancer factor 2D MEF2D Homo sapiens (Human) adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" YRRASEELDGLFR 1 2.5 0.96529 -1.1222 0 0 0 0 0 0 0 9.27961 0 0 0 0 Q14814 MEF2D_HUMAN Myocyte-specific enhancer factor 2D MEF2D Homo sapiens (Human) adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" KIDEEFDK 1 1.6 0.92724 -0.45594 0 0 0 0 0 0 0 9.27429 0 0 0 0 Q14831 GRM7_HUMAN Metabotropic glutamate receptor 7 (mGluR7) GRM7 GPRC1G MGLUR7 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glycosylation [GO:0070085]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]" asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235] adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905] GPSGVPCGDIK;GVREIPASVCTLPCKPGQRK;IYRIFEQGK;SVTWYTIPPTV 4 5.5 0.95558 -0.83656 0 0 11.2158 0 11.4175 7.30624 0 0 0 0 0 0 Q14832 GRM3_HUMAN Metabotropic glutamate receptor 3 (mGluR3) GRM3 GPRC1C MGLUR3 Homo sapiens (Human) "cellular response to stress [GO:0033554]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; negative regulation of adenylate cyclase activity [GO:0007194]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]" astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110] GTGTEECGRINEDR;LFQIPQISYASTSAKLSDK;QFDRYFQSLNPYNNHRNPWFR;TRKCPENFNEAK 4 7.5 0.97703 -1.4917 0 0 0 0 0 10.5152 5.86602 0 0 6.03351 0 0 Q14833 GRM4_HUMAN Metabotropic glutamate receptor 4 (mGluR4) GRM4 GPRC1D MGLUR4 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neurotransmitter secretion [GO:0007269]; positive regulation of MAPK cascade [GO:0043410]; regulation of neuron apoptotic process [GO:0043523]; regulation of synaptic transmission, glutamatergic [GO:0051966]" cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; presynapse [GO:0098793] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066] IERMHWPGSGQQLPR;IYRIFEQGK 2 2.6 0.95156 -0.69353 0 0 0 9.82268 0 0 0 0 0 0 0 0 Q14839 CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553] "centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] APEPTPQQVAQQQ;EEEEEEDDDDDSK;EGEDSSVIHYDDK;FAEMEER;LPATIAR;NILSRLANRAPEPTPQQVAQQQ;TKEGKGPNAR;VLNGYSLQHK 8 4.3 0.97322 -2.5074 4.07313 0 0 9.75579 10.3694 0 8.33016 0 9.93615 0 9.82023 6.37839 Q14847 LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) LASP1 MLN50 Homo sapiens (Human) monoatomic ion transport [GO:0006811] cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; monoatomic ion transmembrane transporter activity [GO:0015075] GFSVVADTPELQR;KTQDQISNIKYHEEFEK;MGPSGGEGMEPER;TGDTGMLPANYVEAI;TQDQISNIKYHEEFEK 5 22.2 0 2.9527 8.76212 10.9127 10.9139 5.63038 0 7.37825 0 0 2.71605 8.49921 9.02625 8.49745 Q14849 STAR3_HUMAN StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3) STARD3 CAB1 MLN64 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lipid metabolic process [GO:0006629]; mitochondrial transport [GO:0006839]; progesterone biosynthetic process [GO:0006701]; steroid metabolic process [GO:0008202]; vesicle tethering to endoplasmic reticulum [GO:0099044] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; organelle membrane contact site [GO:0044232] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; protein homodimerization activity [GO:0042803] ISELGAR;KNLEQEIIQYNFK;TVTACQILQR 3 6.7 0.91514 -0.37028 0 11.5623 0 0 9.74551 0 10.8639 7.57289 7.16802 10.4032 0 12.0875 Q14863 PO6F1_HUMAN "POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein)" POU6F1 BRN5 MPOU TCFB1 Homo sapiens (Human) brain development [GO:0007420]; heart development [GO:0007507]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ELNYDREVVR 1 3.3 0.97461 -1.4255 14.6109 14.346 0 0 0 10.1231 0 0 0 0 0 0 Q14865 ARI5B_HUMAN AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) ARID5B DESRT MRF2 Homo sapiens (Human) adipose tissue development [GO:0060612]; adrenal gland development [GO:0030325]; cell development [GO:0048468]; cellular response to leukemia inhibitory factor [GO:1990830]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] NPQILYCR;WVHSDFSK;YPESLSRSGKPHHVRLENFR 3 3 0.9748 -1.4361 0 0 0 0 0 0 0 0 7.83093 0 0 0 Q14872 MTF1_HUMAN Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) MTF1 Homo sapiens (Human) cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cadmium ion [GO:0046686]; response to metal ion [GO:0010038]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" QEEACQCQCACR 1 1.6 0.80974 0.0064189 0 0 5.14723 0 0 0 0 0 5.89654 0 0 0 Q14894 CRYM_HUMAN Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein) CRYM THBP Homo sapiens (Human) lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sensory perception of sound [GO:0007605]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782] NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; thiomorpholine-carboxylate dehydrogenase activity [GO:0047127]; thyroid hormone binding [GO:0070324]; transcription corepressor activity [GO:0003714] TKENAEKFADTVQGEVR 1 5.4 0.84855 -0.073134 0 0 0 0 8.82496 0 0 0 0 0 0 0 Q14896 MYPC3_HUMAN "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; heart morphogenesis [GO:0003007]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of muscle filament sliding [GO:0032971]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] A band [GO:0031672]; C zone [GO:0014705]; cardiac myofibril [GO:0097512]; cytosol [GO:0005829]; M band [GO:0031430]; sarcomere [GO:0030017]; striated muscle myosin thick filament [GO:0005863] actin binding [GO:0003779]; ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432] CSTELFVK;TMEWFTVLEHYR;YIFESIGAK 3 2.3 0.96664 -1.2824 0 0 0 0 0 8.05588 0 0 0 5.76596 6.49724 0 Q14914 PTGR1_HUMAN Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74) PTGR1 LTB4DH Homo sapiens (Human) leukotriene B4 metabolic process [GO:0036102]; leukotriene metabolic process [GO:0006691]; lipoxin A4 metabolic process [GO:2001302]; prostaglandin metabolic process [GO:0006693] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] 13-lipoxin reductase activity [GO:0036185]; 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity [GO:0047522]; 2-alkenal reductase (NADPH) activity [GO:0035798]; leukotriene B4 12-hydroxy dehydrogenase activity [GO:0097257] GCKVVGAVGSDEK;MEAFVVYR 2 6.4 0.956 -0.83775 0 0 0 0 0 0 0 0 9.37604 0 0 0 Q14919 NC2A_HUMAN Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) DRAP1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366] negative cofactor 2 complex [GO:0017054]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025] KYNARFPPAR 1 4.9 0.86566 -0.092279 0 0 6.50305 0 0 0 0 0 0 0 0 0 Q14934 NFAC4_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)" NFATC4 NFAT3 Homo sapiens (Human) brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; branching involved in blood vessel morphogenesis [GO:0001569]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular respiration [GO:0045333]; cellular response to lithium ion [GO:0071285]; cellular response to UV [GO:0034644]; dendrite morphogenesis [GO:0048813]; heart development [GO:0007507]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synapse maturation [GO:2000297]; negative regulation of Wnt signaling pathway [GO:0030178]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; synapse maturation [GO:0060074]; transcription by RNA polymerase II [GO:0006366]; vascular associated smooth muscle cell development [GO:0097084] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" KGETDIGR;LVFGEEK;VLECPSIR 3 2.5 0.98094 -1.692 0 0 0 0 0 0 0 8.77939 0 0 0 0 Q14940 SL9A5_HUMAN Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) SLC9A5 NHE5 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] dendritic spine membrane [GO:0032591]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202] arrestin family protein binding [GO:1990763]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] EVFQQNMK 1 0.9 0.93735 -0.55287 0 0 0 0 0 0 9.41371 0 0 0 0 0 Q14943 KI3S1_HUMAN Killer cell immunoglobulin-like receptor 3DS1 (Natural killer-associated transcript 10) (NKAT-10) KIR3DS1 NKAT10 Homo sapiens (Human) immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell activation [GO:0030101] plasma membrane [GO:0005886] MHC class I receptor activity [GO:0032393] AGPHMGGQDKPFLSAWPSAVVPR;CCCNGPRACREQK;KCCCNGPR 3 9.7 0.88578 -0.19622 0 0 0 0 5.40163 0 0 0 3.79046 0 11.6888 0 Q14957 NMDE3_HUMAN "Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)" GRIN2C NMDAR2C Homo sapiens (Human) "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process controlling balance [GO:0050885]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to wounding [GO:0009611]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] monoatomic cation channel activity [GO:0005261]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EALLHAAWARGSRPR;GVWNGMIGEVYYKRADMAIGSLTINEER;HRLWEMVGR;TIENWGGGR;TLGLGTGYRDSGGLDEISR 5 6.5 0.96377 -1.2045 0 7.79097 0 0 0 9.10061 10.6227 0 9.07938 0 0 0 Q14966 ZN638_HUMAN Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) ZNF638 NP220 ZFML Homo sapiens (Human) regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ALEDVVQR;LFQPFGKVNDVLIVPYR;NLEDDTLSECKQVSDK;SPFGIVK;TAKSGGK;TEDSSSGKSVASDVPEGEK;TLAEQNTKNPK 7 4.3 0.97259 -2.7748 13.8794 10.1758 13.7223 0 0 9.69876 12.5681 12.6959 12.895 13.6493 13.5965 12.0018 Q14966 ZN638_HUMAN Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) ZNF638 NP220 ZFML Homo sapiens (Human) regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ALEDVVQR;LFQPFGKVNDVLIVPYR;NLEDDTLSECKQVSDK;SPFGIVK;TAKSGGK;TLRILKALLVEVPNLK 6 6.2 0.763 0.068147 0 0 0 4.87735 0 0 0 0 0 0 0 0 Q14973 NTCP_HUMAN Hepatic sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1) SLC10A1 NTCP GIG29 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; cellular response to xenobiotic stimulus [GO:0071466]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; bile acid:sodium symporter activity [GO:0008508]; virus receptor activity [GO:0001618] GLAIALVAQYGIMPLTAFVLGKVFRLK;IKAHLWKPK 2 10.3 0.91518 -0.36779 0 0 0 0 8.41502 0 0 7.51846 0 0 0 0 Q14974 IMB1_HUMAN Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) KPNB1 NTF97 Homo sapiens (Human) astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cholesterol biosynthetic process [GO:0045542]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] enzyme binding [GO:0019899]; Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] AAVENLPTFLVELSR;LAATNALLNSLEFTK;LAATNALLNSLEFTKANFDK;LELEAAQK;MELITILEK;NSLTSKDPDIK;SSAYESLMEIVK;VAAGLQIK;VAALQNLVK;VLANPGNSQVAR 10 11.9 0 24.612 13.8181 13.847 13.4265 11.2554 9.85555 10.6304 10.9022 12.7504 12.5407 11.4908 11.8414 11.4923 Q14978 NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) mitotic cell cycle [GO:0000278]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; GTP binding [GO:0005525]; molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] AAAKASESSSSEESSDDDDEEDQK;AESSNSSSSDDSSEEEEEK;ANGTSALTAQNGK;APPKKAK;ASESSSSEESSDDDDEEDQK;ITPVTVKAQTK;LQANGPVAK;LQTPNTFPK;VAGGAAPSKPASAKKGK;VGLPPGK 10 16.6 0.92885 -0.48223 0 7.76752 0 8.3647 0 0 5.34596 5.75042 10.3809 12.4394 9.20367 8.45381 Q14980 NUMA1_HUMAN Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) anastral spindle assembly [GO:0055048]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; meiotic cell cycle [GO:0051321]; microtubule bundle formation [GO:0001578]; nucleus organization [GO:0006997]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; positive regulation of hair follicle development [GO:0051798]; positive regulation of intracellular transport [GO:0032388]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of mitotic spindle elongation [GO:1902846]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of protein localization to spindle pole body [GO:1902365]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236] cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; chromosome [GO:0005694]; cortical microtubule [GO:0055028]; cytoplasmic microtubule bundle [GO:1905720]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; microtubule minus-end [GO:0036449]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; spindle pole centrosome [GO:0031616] disordered domain specific binding [GO:0097718]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; microtubule plus-end binding [GO:0051010]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; tubulin binding [GO:0015631] ATSCFPRPMTPR;ATSSTQSLAR;EGKDQELAK;ELKRLVMAESEK;HREELEQSKQAAGGLR;IATTTASAATAAAIGATPR;KCLEEKNEILQGK;KLADSDQASK;LADDLSTLQEK;LDFVCSFLQKNRK;LDVEEPDSANSSFYSTR;LEQQCQK;LLQAETASNSAR;LVMAESEK;QDHAQQLATAAEER;QELTSQAER;QTVKQLKEQLAK;SAPASQASLR;SEQQKATEK;VLEERQR;VQDHSKAEDEWKAQVAR 21 11.3 0.97837 -6.5073 12.0968 13.2438 13.2554 0 9.15254 0 0 12.2548 12.4286 12.1053 11.5617 11.828 Q14982 OPCM_HUMAN Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1) OPCML IGLON1 OBCAM Homo sapiens (Human) cell adhesion [GO:0007155]; neuron recognition [GO:0008038] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DYGNYTCVATNK;GVCGYLFLPWK;GVCGYLFLPWKCLVVVSLR 3 9 0.80772 0.011385 0 0 0 0 0 6.31781 0 0 0 0 0 0 Q14990 ODFP1_HUMAN Outer dense fiber protein 1 (Heat shock protein beta-10) (HspB10) (Heat shock protein family B member 10) ODF1 HSPB10 ODFP Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126] SCGLCDLYPCCLCDYK 1 6.4 0.64845 0.17088 0 0 0 0 0 0 0 0 0 0 6.71012 0 Q14993 COJA1_HUMAN Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) COL19A1 Homo sapiens (Human) cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; extracellular matrix organization [GO:0030198]; skeletal muscle tissue development [GO:0007519]; skeletal system development [GO:0001501] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674] LGSALLIRDTIKIFPK 1 1.4 0.75887 0.071888 0 0 0 0 0 0 0 0 0 0 5.14033 0 Q14994 NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) NR1I3 CAR Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" MASREDELR 1 2.6 0.98033 -1.5723 0 0 0 0 0 0 0 0 8.72901 0 0 0 Q14995 NR1D2_HUMAN Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R) NR1D2 Homo sapiens (Human) cell differentiation [GO:0030154]; circadian behavior [GO:0048512]; energy homeostasis [GO:0097009]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LLLKLPDLR;NDRIDCSMKTSK 2 3.6 0.76708 0.058517 0 0 0 8.4192 0 0 0 0 0 0 0 0 Q14997 PSME4_HUMAN Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) PSME4 BLM10 KIAA0077 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; sperm DNA condensation [GO:0035092] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111] lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628] AAVKCCPEESLK;EIFMVALQK;FNPRRFCLFK;IFTRILRSLNLPVGSSQVLVPR;LCLSLMSQGLLYPHQVPLVLQVLK;RQQEKNADALR;TLTVEGCEYKKIHQDMIR;VLPLRAIR;VPELLHRLLK 9 6.7 0.97408 -1.4207 0 12.7681 0 4.94734 0 0 0 10.468 10.5388 0 0 0 Q14999 CUL7_HUMAN Cullin-7 (CUL-7) CUL7 KIAA0076 Homo sapiens (Human) epithelial to mesenchymal transition [GO:0001837]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; placenta development [GO:0001890]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]; vasculogenesis [GO:0001570] 3M complex [GO:1990393]; anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625] GPAFFSR;VGELRYR 2 0.8 0.96564 -1.2407 0 0 0 0 0 0 0 0 0 0 0 10.4443 Q149M9 NWD1_HUMAN NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of gene expression [GO:0010628] cytosol [GO:0005829]; nucleolus [GO:0005730] ATP binding [GO:0005524] ASPQDPLK;DLVNPKNK;FEMSYTSSYCR;KLITLPLVGKPLNLDRK;LAFEEARK 5 3.3 0.97322 -2.5119 0 0 0 10.7477 0 0 0 0 0 0 3.60798 7.44518 Q149N8 SHPRH_HUMAN "E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" SHPRH KIAA2023 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleosome [GO:0000786] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] AVATSQLQK;EPMSICDKGILVESSFSGEMLEDLGWLQK;KNPQHLYSFIAK;KPRVQCLK;LLYRPYCKK;LSMSEKFRDCR;SITLMSSESSNQFLIYVHSK;SSIKCAICRQTTSHK;SSSLRVLVYQGVK;VRDPREPKPNPPVLHIIEPHEVEQNR;YVSSIYRYDVQRNR 11 9.8 0.97631 -5.0076 16.6844 0 0 9.41068 10.4051 11.1202 0 9.63902 9.05778 11.3895 8.72996 10.1449 Q14BN4 SLMAP_HUMAN Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) muscle contraction [GO:0006936]; negative regulation of hippo signaling [GO:0035331]; protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of voltage-gated sodium channel activity [GO:1905150] centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; FAR/SIN/STRIPAK complex [GO:0090443]; M band [GO:0031430]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] protein-macromolecule adaptor activity [GO:0030674] AASEYEK;DSEITSTRDELLSAR;ELANKYNGAVNEIK;HVYLDEPIK;KELQHKIDEMEEK;KVTHGCIVSTIK;SLSNTEDECTHLK;VSLLKDDLQGAQSEIEAK 8 12.2 0.97964 -1.997 5.59607 0 0 0 9.89361 6.14904 10.401 0 10.6596 0 9.24479 7.51657 Q14BN4 SLMAP_HUMAN Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) muscle contraction [GO:0006936]; negative regulation of hippo signaling [GO:0035331]; protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of voltage-gated sodium channel activity [GO:1905150] centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; FAR/SIN/STRIPAK complex [GO:0090443]; M band [GO:0031430]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] protein-macromolecule adaptor activity [GO:0030674] AASEYEK;DSEITSTRDELLSAR;LTALQENQTRAK;VSLLKDDLQGAQSEIEAK 4 11.5 0.91801 -0.43522 11.9921 0 0 0 0 0 0 0 0 0 0 0 Q14C86 GAPD1_HUMAN GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) GAPVD1 GAPEX5 KIAA1521 RAP6 Homo sapiens (Human) endocytosis [GO:0006897]; regulation of protein transport [GO:0051223] cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] APIPFRK;DMMGLTDDR;DSDDEKSDRNRPWWR;LYVNSEKQLIQR;QLIQRLNADVLK;VVTANHRALQIPEVYLR 6 4.5 0.98036 -1.8121 3.18439 0 11.2738 7.73971 7.03474 0 0 6.95093 0 0 8.05344 8.28887 Q14C87 T132D_HUMAN Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein) TMEM132D HBE120 KIAA1944 MOLT Homo sapiens (Human) membrane [GO:0016020] LDNSVAIHYIPK;NSTEDRFTLRAK;YLLSTNSQK 3 3 0.96381 -1.2011 0 0 0 0 9.852 0 0 12.3447 10.084 0 0 0 Q14CB8 RHG19_HUMAN Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) ARHGAP19 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GSSSCGCCS;LNSGMAFMIK 2 3.7 0.95526 -0.8596 0 0 0 0 0 0 0 0 7.01903 0 0 0 Q14CM0 FRPD4_HUMAN FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso) FRMPD4 KIAA0316 PDZD10 PDZK10 Homo sapiens (Human) positive regulation of synapse structural plasticity [GO:0051835] cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; protein-containing complex [GO:0032991] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" APGLPNHGATFK;DSQHLSTFNLER;LADGEGKAPPNGNTTGK;LLVDSRRSIFNMANK;LSALQAK 5 4.8 0.94609 -0.65379 0 3.80591 12.336 10.8094 0 0 0 0 0 10.9449 0 10.1032 Q14CN2 CLCA4_HUMAN "Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]" CLCA4 CaCC2 UNQ562/PRO1124 Homo sapiens (Human) monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] IVCLVLDK;SGSMGGK 2 1.6 0.65068 0.17065 12.7313 12.5974 0 10.6032 8.91256 0 10.5322 0 9.45074 0 11.9886 0 Q14CN4 K2C72_HUMAN "Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)" KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] DLDLDSIIAEVR;FASFIDK;FASFIDKVR;RYEVEINRR;SRQLTHFPRGER;TAAENEFVVLK;TAAENEFVVLKK 7 10.6 0.96694 -1.2915 0 0 0 9.84249 0 0 11.219 10.8122 0 0 0 0 Q14CW9 AT7L3_HUMAN Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) ATXN7L3 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] DUBm complex [GO:0071819]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] SDKLWYLPFQNPNSPR 1 4.5 0.91683 -0.42235 0 0 0 0 0 0 0 0 0 0 6.81622 0 Q14CX7 NAA25_HUMAN "N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)" NAA25 C12orf30 MDM20 NAP1 Homo sapiens (Human) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416] acetyltransferase activator activity [GO:0010698] AIGLQRTGK;LLGLYHTMDK 2 2 0.97825 -2.0693 0 0 0 0 0 0 11.9196 0 12.5967 0 0 0 Q14CZ7 FAKD3_HUMAN "FAST kinase domain-containing protein 3, mitochondrial" FASTKD3 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial RNA processing [GO:0000963]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] FHHAHCKK;IALCIDGPKR;NKPLNHVHKVVKER 3 4.8 0.96922 -1.3329 0 0 0 0 3.0868 10.1364 0 0 0 0 0 0 Q14D04 MELT_HUMAN Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) VEPH1 KIAA1692 VEPH Homo sapiens (Human) negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of signal transduction [GO:0009966] plasma membrane [GO:0005886] phosphatidylinositol-5-phosphate binding [GO:0010314] AYAMEIGKKIPVPDQCTIEDTVR;DLDQVQLHLEEVR;GVGSDDGEDENR;RKISTEIEFPEK;SILQGNTMLLR 5 8.5 0.91588 -0.33441 10.4744 7.45434 0 0 0 0 0 0 0 10.4356 5.26074 7.41608 Q14DG7 T132B_HUMAN Transmembrane protein 132B TMEM132B KIAA1786 KIAA1906 Homo sapiens (Human) membrane [GO:0016020] AVQEWFHR;EVAASCR 2 1.4 0.7776 0.037632 0 0 0 0 0 7.40233 0 0 0 0 6.94228 0 Q15003 CND2_HUMAN Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) NCAPH BRRN BRRN1 CAPH KIAA0074 Homo sapiens (Human) cell division [GO:0051301]; female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] EAALAEVADEK;IEIHYAK;MLSGLTKDLQR;QDAPSQSENK;VLGGLGK 5 6.2 0.97329 -2.9697 13.8732 0 0 0 0 0 0 0 0 0 0 10.112 Q15007 FL2D_HUMAN Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) WTAP KIAA0105 Homo sapiens (Human) "mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] identical protein binding [GO:0042802] LSETDFK 1 1.8 0.81406 -0.00056485 0 0 9.22224 0 0 0 0 0 0 0 0 0 Q15008 PSMD6_HUMAN 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) PSMD6 KIAA0107 PFAAP4 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774] IDKVNEIVETNRPDSK;SLIEEGGDWDRR 2 7.2 0.71303 0.14919 9.97571 6.84812 0 0 6.97808 0 0 0 0 0 0 0 Q15011 HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) HERPUD1 HERP KIAA0025 MIF1 Homo sapiens (Human) "endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein targeting to ER [GO:0045047]; regulation of ERAD pathway [GO:1904292]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Lewy body core [GO:1990037]; membrane [GO:0016020] transmembrane transporter binding [GO:0044325]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GQYPEDSSSDGLRQREVLR;LLLDHQCLRDLLPKQEK 2 9.2 0.079365 0.39626 0 0 0 0 0 0 0 0 0 5.24138 6.3427 0 Q15013 MD2BP_HUMAN MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) MAD2L1BP CMT2 KIAA0110 Homo sapiens (Human) deactivation of mitotic spindle assembly checkpoint [GO:1902426]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] VPLGRSLTLSPR 1 3.9 0.88812 -0.18442 0 0 0 0 0 0 0 10.5188 0 0 0 0 Q15014 MO4L2_HUMAN Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) MORF4L2 KIAA0026 MRGX Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; plasma membrane [GO:0005886] GASSGKK 1 2.4 0.64944 0.171 0 0 0 0 0 0 0 9.75641 9.62425 0 14.7042 0 Q15018 ABRX2_HUMAN BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) ABRAXAS2 ABRO1 FAM175B KIAA0157 Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536]; response to ischemia [GO:0002931] BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593] VIGWYRFR;VQAVCADVEKSERVVESCQAEVNK 2 7.7 0.95282 -0.76546 0 0 0 0 9.30852 0 0 0 0 9.4549 0 0 Q15019 SEPT2_HUMAN Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) SEPTIN2 DIFF6 KIAA0158 NEDD5 SEPT2 Homo sapiens (Human) cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; regulation of exocytosis [GO:0017157]; regulation of L-glutamate import across plasma membrane [GO:0002036]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] cadherin binding [GO:0045296]; enzyme regulator activity [GO:0030234]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] ASIPFSVVGSNQLIEAK;MQEMIAR;VNIVPVIAK 3 9.1 0 2.465 0 0 0 0 0 0 10.0158 0 10.1208 0 7.58699 10.7832 Q15020 SART3_HUMAN Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) SART3 KIAA0156 TIP110 Homo sapiens (Human) "cell morphogenesis [GO:0000902]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of gene expression [GO:0010468]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]" ASAP complex [GO:0061574]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; RNA binding [GO:0003723]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381] AHGDTQHCRKALHR;ATAAETSASEPEAESKAGPK;GADEDDEKEWGDDEEEQPSK;GDFRGYCYVEFK;IRGPEKR;KVPEKPETR;VAISNPPQR 7 9.4 0.97331 -2.4951 0 0 3.10724 11.8035 9.23606 0 0 0 0 12.2754 0 0 Q15021 CND1_HUMAN Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) NCAPD2 CAPD2 CNAP1 KIAA0159 Homo sapiens (Human) cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" histone binding [GO:0042393] AIIDEFEQK;GQVSEMAVLLIDPEPQIAALAKNFFNELSHK;LPQEHRLFER;MLDNFDCFGDK 4 4.4 0.96738 -1.3135 0 0 6.02421 10.1347 0 0 0 0 0 5.91212 9.32986 0 Q15022 SUZ12_HUMAN Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) SUZ12 CHET9 JJAZ1 KIAA0160 Homo sapiens (Human) cell population proliferation [GO:0008283]; facultative heterochromatin formation [GO:0140718]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; random inactivation of X chromosome [GO:0060816] chromatin silencing complex [GO:0005677]; ESC/E(Z) complex [GO:0035098]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; sex chromatin [GO:0001739] chromatin DNA binding [GO:0031490]; enzyme activator activity [GO:0008047]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222] NLIAPIFLHR 1 1.4 0.81185 0.0033675 0 0 0 0 0 0 0 0 0 0 10.3845 0 Q15024 EXOS7_HUMAN Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) EXOSC7 KIAA0116 RRP42 Homo sapiens (Human) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723] AALFNTRIPRVR;GGDDLGTEIANTLYRIFNNK;GVVTCMRKVGK 3 14.8 0.9732 -2.5675 0 17.198 0 0 15.7587 15.2214 0 0 0 11.1961 0 7.95198 Q15025 TNIP1_HUMAN TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) TNIP1 KIAA0113 NAF1 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; translation [GO:0006412] cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019] IFEEDFQR;LPCGGVR;LQAQVTLSNAQLK;MALEFNRLASK;NPNQSSQVMDPPTARPTEPESPK 5 9.7 0.95568 -0.82787 0 11.1912 0 0 0 0 9.2567 7.75842 0 7.80193 9.60672 0 Q15027 ACAP1_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)" ACAP1 CENTB1 KIAA0050 Homo sapiens (Human) protein transport [GO:0015031] membrane [GO:0016020]; recycling endosome membrane [GO:0055038] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] ALDYALQINVIEDK;EGLRGFREAR;LGTGLLESGRHYLAASR;TVKLDFEECLK;WFTIQSNQLVYQKKYK 5 9.2 0.96459 -1.1643 0 10.4447 0 9.48071 0 0 0 0 0 7.44634 0 0 Q15029 U5S1_HUMAN "116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)" EFTUD2 KIAA0031 SNRP116 Homo sapiens (Human) "cellular response to xenobiotic stimulus [GO:0071466]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U5 snRNA binding [GO:0030623] GGGQIIPTAR;HAVQERLAVTVCINK;IAVEPVNPSELPK;ILDAVVAQEPLHR;LNIRPLLRLVCKK;STPVTVVLPDTK 6 7.8 0.13937 0.35261 11.4676 10.2367 11.2639 0 4.77141 0 0 0 10.5809 17.4379 10.6336 0 Q15031 SYLM_HUMAN "Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" LARS2 KIAA0028 Homo sapiens (Human) leucyl-tRNA aminoacylation [GO:0006429]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] LEVTWEK;LYEAGLAYQK 2 1.9 0.94164 -0.60354 0 11.5887 9.34239 0 0 0 0 0 0 0 0 0 Q15032 R3HD1_HUMAN R3H domain-containing protein 1 R3HDM1 KIAA0029 R3HDM Homo sapiens (Human) RNA binding [GO:0003723] DPQSQPRR 1 0.7 0.83937 -0.043952 0 0 0 0 9.6361 0 11.6264 0 0 0 0 0 Q15034 HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3) HERC3 KIAA0032 Homo sapiens (Human) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410] ubiquitin protein ligase activity [GO:0061630] LFWETFHEFPLEKK;LIPGGDNVTVCKDNR;RNNLVGDALR;SPFLVLHVRR 4 4.6 0.9379 -0.5703 0 0 0 0 0 6.86641 0 0 0 10.5628 0 0 Q15035 TRAM2_HUMAN Translocating chain-associated membrane protein 2 TRAM2 KIAA0057 Homo sapiens (Human) "collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum membrane [GO:0005789] EEIPRQLQYICLYLVHIAGAYLLNLSR;RVPATPR;VRKEEIPR 3 10 0.89771 -0.23802 0 0 0 0 0 7.0187 0 0 0 9.66825 0 10.198 Q15036 SNX17_HUMAN Sorting nexin-17 SNX17 KIAA0064 Homo sapiens (Human) aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cholesterol catabolic process [GO:0006707]; coronary vasculature development [GO:0060976]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; receptor-mediated endocytosis [GO:0006898]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991] low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol binding [GO:0035091]; signaling receptor binding [GO:0005102] LSAVSLR;VTRMRCWR 2 3.2 0.92921 -0.46504 0 0 0 0 0 0 10.8523 0 0 0 0 0 Q15041 AR6P1_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum) ARL6IP1 ARL6IP ARMER KIAA0069 Homo sapiens (Human) apoptotic process [GO:0006915]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of L-glutamate import across plasma membrane [GO:0002038]; regulation of endoplasmic reticulum tubular network organization [GO:1903371] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784] identical protein binding [GO:0042802] FHEICSNLVKTRR 1 6.4 0.87002 -0.094479 0 0 0 0 0 0 0 0 0 5.73349 0 0 Q15042 RB3GP_HUMAN Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) RAB3GAP1 KIAA0066 RAB3GAP Homo sapiens (Human) brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AGDQLVPDNLKETDK;VPNQYTHLSGLLDIFK 2 3.2 0.95252 -0.73724 0 9.87606 0 0 0 0 0 0 0 0 11.744 0 Q15043 S39AE_HUMAN Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 KIAA0062 ZIP14 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; chondrocyte differentiation [GO:0002062]; gluconeogenesis [GO:0006094]; import across plasma membrane [GO:0098739]; inorganic cation transmembrane transport [GO:0098662]; insulin receptor signaling pathway [GO:0008286]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; manganese ion homeostasis [GO:0055071]; manganese ion transmembrane transport [GO:0071421]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; regulation of hormone levels [GO:0010817]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadmium ion transmembrane transporter activity [GO:0015086]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; monoatomic anion:monoatomic cation symporter activity [GO:0015296]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] ILKILLKQK;LLLLHPAFQSCLLLTLLGLWR 2 6.1 0.19225 0.33543 0 6.02086 0 8.56647 0 0 0 0 0 0 0 0 Q15046 SYK_HUMAN Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) KARS1 KARS KIAA0070 Homo sapiens (Human) basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032]; response to X-ray [GO:0010165]; tRNA processing [GO:0008033] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] amino acid binding [GO:0016597]; ATP binding [GO:0005524]; ATP:ADP adenylyltransferase activity [GO:0003877]; identical protein binding [GO:0042802]; lysine-tRNA ligase activity [GO:0004824]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] AAVQAAEVKVDGSEPK;AVECPPPR;ILDDICVAK;MVSGMVK;VAMFLTDSNNIK;YLDLILNDFVRQKFIIR 6 11.6 0 4.6588 0 9.57421 11.5098 0 0 8.87596 0 0 3.37267 8.87563 0 9.80462 Q15047 SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) SETDB1 ESET KIAA0067 KMT1E Homo sapiens (Human) DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; transposable element silencing by heterochromatin formation [GO:0141005] chromosome [GO:0005694]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H3K9me2 methyltransferase activity [GO:0140947]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270] ILFLDDK;LVQHGLQVRLQLFK;QLAELETWVIQK;SSSQDLHK;SSSQDLHKGTLSQMSGELSK;TPKDQKLR 6 4.7 0.9735 -2.5536 7.41312 0 0 0 0 0 0 7.15512 0 0 12.8118 12.8213 Q15048 LRC14_HUMAN Leucine-rich repeat-containing protein 14 LRRC14 KIAA0014 Homo sapiens (Human) negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900] FQHLASLRLHYVHGDSR;LHYVHGDSR 2 3.4 0.96423 -1.207 0 0 0 0 0 9.77391 0 0 0 0 0 0 Q15049 MLC1_HUMAN Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) MLC1 KIAA0027 WKL1 Homo sapiens (Human) caveolin-mediated endocytosis [GO:0072584]; cellular response to cholesterol [GO:0071397]; positive regulation of intracellular transport [GO:0032388]; protein transport [GO:0015031]; regulation of response to osmotic stress [GO:0047484]; vesicle-mediated transport [GO:0016192] basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] CLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFK;LAGEVAR 2 11.4 0.95551 -0.81103 0 13.5287 13.2933 0 0 0 0 0 9.38795 0 0 12.7094 Q15050 RRS1_HUMAN Ribosome biogenesis regulatory protein homolog RRS1 KIAA0112 RRR Homo sapiens (Human) "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase chromosome alignment [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]" "condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723] QGPGGKR 1 1.9 0.93032 -0.48841 0 0 0 0 0 0 0 0 0 9.77032 0 0 Q15051 IQCB1_HUMAN IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) IQCB1 KIAA0036 NPHP5 OK/SW-cl.85 Homo sapiens (Human) cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750] BBSome binding [GO:0062063]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674] LLLLMAESHQEILILLR;LPSAVIALQRSFR 2 5 0.76527 0.064225 0 0 11.4644 5.33425 0 0 0 0 0 0 0 0 Q15052 ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) ARHGEF6 COOL2 KIAA0006 PIXA Homo sapiens (Human) apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; lamellipodium assembly [GO:0030032] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] MKQCLEEELK;NGVVLCKLINRLMPGSVEK;TICDPEEFLKSSLK;VLSTLLAVNK 4 6.8 0.97535 -3.5925 0 0 0 0 10.7722 0 0 8.94251 0 0 0 0 Q15053 K0040_HUMAN Uncharacterized protein KIAA0040 KIAA0040 Homo sapiens (Human) membrane [GO:0016020] KDEEDLWISAQPK 1 13.1 0.65602 0.16951 0 0 0 0 9.56874 0 0 0 0 0 0 0 Q15054 DPOD3_HUMAN DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) POLD3 KIAA0039 Homo sapiens (Human) "DNA biosynthetic process [GO:0071897]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]" cytoplasm [GO:0005737]; delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; zeta DNA polymerase complex [GO:0016035] protein-macromolecule adaptor activity [GO:0030674] AEPVKVLQK;LYDYVER;TEPEPPSVK 3 5.9 0.96571 -1.1332 0 0 0 0 0 0 0 8.73715 0 0 0 0 Q15056 IF4H_HUMAN Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) EIF4H KIAA0038 WBSCR1 WSCR1 Homo sapiens (Human) developmental growth [GO:0048589]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] "cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" ADFDTYDDR;EEVVQKEQE;EPTEEERAQRPRLQLKPR;TGPPMGSR;TVATPLNQVANPNSAIFGGARPR 5 27 0.84056 -0.047632 0 0 11.0845 0 9.21791 10.2738 10.7973 0 11.0238 8.35826 7.12866 0 Q15057 ACAP2_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 KIAA0041 Homo sapiens (Human) actin filament-based process [GO:0030029]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456] endosome membrane [GO:0010008]; membrane [GO:0016020]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AQLQNFVKEDLR;EAYIRAKYVER;HLNPGLQLYRASYEK;MGIKKPQPGQR;SSEEKRLSISK;YSISLSPPEQQK 6 9.3 0.98068 -1.7806 0 8.30497 0 7.29637 8.47541 0 0 9.09592 8.22675 0 0 0 Q15058 KIF14_HUMAN Kinesin-like protein KIF14 KIF14 KIAA0042 Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631] IEELEKAK;KMQEINNQKANHK;RQVQEENFEYQDFKR;TAEIDSVKMTLNVGGETENNGVSK;VLGTGNLYHR;VRNLKLGISTFWSLEK 6 5.2 0.98034 -1.5965 0 15.5646 0 9.83515 0 0 0 10.1371 0 0 3.33942 0 Q15059 BRD3_HUMAN Bromodomain-containing protein 3 (RING3-like protein) BRD3 KIAA0043 RING3L Homo sapiens (Human) chromatin remodeling [GO:0006338]; endodermal cell differentiation [GO:0035987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromatin [GO:0071168]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; lncRNA binding [GO:0106222]; lysine-acetylated histone binding [GO:0070577]; molecular condensate scaffold activity [GO:0140693]; protein serine/threonine kinase activity [GO:0004674] AKVAPPAKQAQQK;AVHEQLAALSQAPVNKPK;AVHEQLAALSQAPVNKPKK;LAELQEQLK;LSSSSSSESGSSSSSGSSSDSSDSE 5 9.1 0.96494 -1.2492 0 12.5428 0 10.6661 11.1166 0 0 0 0 9.18671 6.2528 0 Q15061 WDR43_HUMAN WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) WDR43 KIAA0007 UTP5 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; ribosomal small subunit biogenesis [GO:0042274]" chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711] DEENGEDR;ELNGDSDLDPENESEEE 2 3.7 0.93667 -0.55733 0 7.89785 0 0 0 0 0 0 0 6.97269 0 0 Q15063 POSTN_HUMAN Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) POSTN OSF2 Homo sapiens (Human) bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; tissue development [GO:0009888] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; trans-Golgi network [GO:0005802] cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; metal ion binding [GO:0046872] LLKLILQNHILK;LLQEDTPVRK;TAVCIENSCMEKGSK;VGLNELYNGQILETIGGKQLR;VIEGSLQPIIKTEEPIIK;VVEPKIK;YSDASKLREEIEGK 7 12.5 0.9631 -1.0852 10.7732 9.23544 6.17055 7.69411 7.47557 0 9.23372 0 0 0 8.56948 0 Q15063 POSTN_HUMAN Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) POSTN OSF2 Homo sapiens (Human) bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; tissue development [GO:0009888] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; trans-Golgi network [GO:0005802] cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; metal ion binding [GO:0046872] EGETITEVIHGEPIIKKYTK;LLKLILQNHILK;LLQEDTPVRK;TAVCIENSCMEKGSK;VGLNELYNGQILETIGGKQLR;VVEPKIK;YSDASKLREEIEGK 7 12.3 0.46223 0.19077 0 0 0 0 0 0 0 0 0 0 9.02137 0 Q15070 OXA1L_HUMAN Mitochondrial inner membrane protein OXA1L (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) OXA1L Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial protein quality control [GO:0141164]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial translation [GO:0032543]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803] AMGLMCGRR 1 2.1 0.76957 0.055409 0 0 0 0 0 0 10.2391 0 0 0 0 0 Q15075 EEA1_HUMAN Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) EEA1 ZFYVE2 Homo sapiens (Human) "chemical synaptic transmission, postsynaptic [GO:0099565]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; modulation by host of viral process [GO:0044788]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]" axonal spine [GO:0044308]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynaptic early endosome [GO:0098842]; presynaptic endosome [GO:0098830]; recycling endosome [GO:0055037]; Schaffer collateral - CA1 synapse [GO:0098685]; serine-pyruvate aminotransferase complex [GO:0005969] 1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] ADLQNHLDTAQNALQDK;ALLERCLK;ATLEQDSAKK;LEEKHNEESVSK;LKEELSEVETKYQHLK;QLLIQQK;RNQQILK;TAKATLEQDSAK 8 5.7 0.97488 -3.4584 5.16591 7.53737 14.0863 14.5189 15.4337 0 9.29717 0 2.38153 0 9.80166 0 Q15080 NCF4_HUMAN Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox) NCF4 SH3PXD4 Homo sapiens (Human) phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886] phosphatidylinositol-3-phosphate binding [GO:0032266]; superoxide-generating NADPH oxidase activator activity [GO:0016176] DIAVEEDLSSTPLLK;DLLELTRR;GGSKYLIYRR 3 9.7 0.73082 0.1141 0 0 13.7121 0 0 8.34895 0 0 0 0 0 13.4185 Q15084 PDIA6_HUMAN Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) PDIA6 ERP5 P5 TXNDC7 Homo sapiens (Human) protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; plasma membrane [GO:0005886] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] DGELPVEDDIDLSDVELDDLGK;DGELPVEDDIDLSDVELDDLGKDEL;GSFSEQGINEFLR;GSTAPVGGGAFPTIVER;LAAVDATVNQVLASR;LTPEWKK;NSYLEVLLK;SGGYSSGK;TGEAIVDAALSALR 9 24.5 0 34.094 11.5523 13.7918 12.1442 10.6894 11.3941 10.8539 13.669 13.0692 11.7434 11.9293 9.14275 13.4265 Q15102 PA1B3_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) PAFAH1B3 PAFAHG Homo sapiens (Human) lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283] 1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] LLAQDQGQGAPLLEPAP;VVVLGLLPR 2 11.3 0.96556 -1.2408 0 0 0 0 0 0 0 0 0 9.05642 0 0 Q15109 RAGE_HUMAN Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) AGER RAGE Homo sapiens (Human) "astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; microglial cell activation [GO:0001774]; negative regulation of blood circulation [GO:1903523]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of chemokine production [GO:0032722]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of endothelin production [GO:1904472]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of inflammatory response [GO:0050727]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; laminin receptor activity [GO:0005055]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] GEEGPRKPGGR;LGGGPWDSVAR 2 6.4 0.97802 -1.5274 0 0 0 0 8.81871 0 0 0 0 0 0 0 Q15109 RAGE_HUMAN Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) AGER RAGE Homo sapiens (Human) "astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; microglial cell activation [GO:0001774]; negative regulation of blood circulation [GO:1903523]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of chemokine production [GO:0032722]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of endothelin production [GO:1904472]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of inflammatory response [GO:0050727]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; laminin receptor activity [GO:0005055]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] LEWKLNTGR;SNWWWSQK 2 14 0.94603 -0.65337 0 0 0 0 0 0 0 0 0 9.10001 0 0 Q15111 PLCL1_HUMAN Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) PLCL1 Homo sapiens (Human) "gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" cytoplasm [GO:0005737] phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] DPSNQKCGGR;IANEYPEDFVNYNKKFLSR;IYNRFFTLDTDLQALR;SFVGDIMEHVTLFVHIAITNR;SLSVRMGKK 5 6.8 0.97494 -3.187 0 0 0 8.67151 0 6.81327 8.98391 0 8.09682 0 0 0 Q15116 PDCD1_HUMAN Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) PDCD1 PD1 Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of immune response [GO:0050777]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of tolerance induction [GO:0002644]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of immune response [GO:0050776]; regulatory T cell apoptotic process [GO:1902482] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] ESLRAELR 1 2.8 0.91313 -0.33804 0 0 8.37347 0 0 0 0 0 0 0 0 0 Q15118 PDK1_HUMAN "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)" PDK1 PDHK1 Homo sapiens (Human) cell population proliferation [GO:0008283]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] AVPLAGFGYGLPISR 1 3.4 0.89286 -0.2235 0 0 0 0 0 0 0 10.2612 0 0 0 0 Q15120 PDK3_HUMAN "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)" PDK3 PDHK3 Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; cellular response to glucose stimulus [GO:0071333]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peptidyl-serine phosphorylation [GO:0018105]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] LFRWLLK;SAWRHYK;TSYMFLRK;WLLKQPVPK 4 6.7 0.98068 -1.6472 0 0 0 0 0 7.98123 0 11.4958 0 9.41297 0 0 Q15124 PGM5_HUMAN Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) PGM5 PGMRP Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; myofibril assembly [GO:0030239]; striated muscle tissue development [GO:0014706] adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; spot adherens junction [GO:0005914]; stress fiber [GO:0001725]; Z disc [GO:0030018] magnesium ion binding [GO:0000287]; structural molecule activity [GO:0005198] IDLSRLGRQEFDLENK;IYQISKTIEEYAICPDLR 2 6 0.89775 -0.23865 0 0 8.80626 9.37708 10.9896 6.80723 0 0 0 7.72144 0 0 Q15125 EBP_HUMAN "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Cholesterol-5,6-epoxide hydrolase subunit EBP) (EC 3.3.2.11) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)" EBP Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; ossification involved in bone maturation [GO:0043931] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] C-8 sterol isomerase activity [GO:0000247]; cholestenol delta-isomerase activity [GO:0047750]; identical protein binding [GO:0042802]; steroid delta-isomerase activity [GO:0004769] AAVVPLGTWR 1 4.3 0.68271 0.16547 0 0 11.2499 0 0 9.14328 0 11.4167 11.355 0 8.89409 0 Q15126 PMVK_HUMAN Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2) PMVK PMKI Homo sapiens (Human) "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; response to cholesterol [GO:0070723]; sterol biosynthetic process [GO:0016126]" cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; peroxisome [GO:0005777] ATP binding [GO:0005524]; phosphomevalonate kinase activity [GO:0004631] DMIRWGEEKR;LGADVCAVLR 2 10.4 0.97558 -1.4599 0 0 0 0 0 10.3277 0 0 6.518 0 0 0 Q15131 CDK10_HUMAN Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE) CDK10 Homo sapiens (Human) cell projection organization [GO:0030030]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cilium assembly [GO:1902018]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of MAPK cascade [GO:0043410]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; traversing start control point of mitotic cell cycle [GO:0007089] ciliary basal body [GO:0036064]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ATAGDCLESSYFK;DKEKDGIPISSLR;EITLLLRLRHPNIVELK 3 15.8 0.97262 -2.6211 0 0 0 0 0 8.49193 0 0 0 0 9.29129 0 Q15139 KPCD1_HUMAN Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) PRKD1 PKD PKD1 PRKCM Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; cellular response to angiotensin [GO:1904385]; cellular response to endothelin [GO:1990859]; cellular response to hydroperoxide [GO:0071447]; cellular response to norepinephrine stimulus [GO:0071874]; cellular response to oxidative stress [GO:0034599]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of endocytosis [GO:0045806]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of keratinocyte proliferation [GO:0010837]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril [GO:0014723]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] autophagosome membrane [GO:0000421]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" ELECKIGERYITHESDDLR;LRFPTKQESQLR;QGLKCEGCGLNYHKR;VFVVMEK 4 5.8 0.9667 -1.287 0 0 0 6.6532 0 0 0 0 0 0 0 0 Q15147 PLCB4_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)" PLCB4 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating endothelin receptor signaling pathway [GO:0160135]; release of sequestered calcium ion into cytosol [GO:0051209] cytosol [GO:0005829]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] GLVTVEDEQAWMASYK;LAMKQSK;LAMKQSKEMDQLK;SIKNKAER 4 3.1 0.97479 -4.0629 0 0 0 8.71256 0 0 0 0 0 3.66232 0 0 Q15149 PLEC_HUMAN Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 Homo sapiens (Human) actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion organization [GO:0007005]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization [GO:0008104]; protein-containing complex organization [GO:0043933]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060] axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] AAEEAEEAR;AGVAAPATQVAQVTLQSVQR;AGVVGPELHEQLLSAEK;AHAFAVQQK;ALAEEAKR;ALQALEELR;APVPASELLASGVLSR;AQAEAQQPTFDALRDELR;AQAEQAALR;AQAEVEGLGK;AQLEPVASPAK;AQVEQELTTLR;ASDSELER;ATTAALLLEAQAATGFLVDPVR;ATVSAPFGK;CQRCISELKDIR;DDGTGQLLLPLSDAR;DSQDAGGFGPEDR;DTHDQLSEPSEVR;DVGAYSK;EAEGQLQK;EAQAVPATLPELEATK;EGLTSIEEVTK;EGVMVAKKDR;ELAEEAAR;ELAEQELEK;ELAQEQAR;ELQNAGDR;ELYQQLQRGERSVR;ESADPLGAWLQDAR;ESYSALMR;FAEQTLR;FLQEEAEK;FPVTDAVNK;GAEKAEVVETTQVYTEEETR;GAQEVGER;GGAEGELQALR;GGELVYTDSEAR;GIYQSLEGAVQAGQLK;GLIVREHGIR;GLKLTVEEAVRMGIVGPEFK;GRLCFEGLR;GTQGAEEVLR;GYFDEEMNR;GYLNKDTHDQLSEPSEVR;IISLETYNLLR;LAAEQELIR;LAAIGEATR;LAEQQRAEER;LAEVEAALEK;LAQGHTTVDELAR;LDLQYAK;LHVAILEREKQLR;LISLFQAMK;LLAAGKVPQRAGEVER;LLDAQLATGGIVDPR;LLDAQLSTGGIVDPSK;LLDPEDVDVPQPDEK;LLEAAAQSTK;LLFNDVQTLK;LLLWSQR;LQAEEAER;LQAEEAERR;LQAEEVAQQK;LQEAGILSAEELQR;LQLEATER;LRAETEQGEQQR;LSIYNALK;LSVAAQEAAR;LSYTQLLR;LTVNEAVK;LVASMEEAR;MQAVQEATR;MQEEVVR;MSAAQALK;MVEGYQGLR;NDDIADGNPK;NLLDEELQR;NLVDNITGQR;QAEEIGEK;QAEVELASR;QAQEEAER;QELEAELAK;QEQALLEEIER;QLAAEEER;QLAEAHAQAK;QLAEEDAAR;QLAEEDLAQQR;QLAEGTAQQR;QLQLAQEAAQK;QQEELLAEENQR;QQGLASYDYVR;QQQQMEQER;QSAEEQAQAR;QSSEAEIQAK;QTNLENLDQAFSVAER;QVAEEAAR;QVEEEILALK;QVEVTVHK;QVQDESQR;QVQVALETAQR;QYDIDDAIAK;REEAAVDAQQQK;RQQEELLAEENQR;SAEAELQSK;SALDQYR;SDEGQLSPATR;SIQEELQQLR;SLAQAEAEK;SLLAWQSLRRDVQLIR;SLQEEHVAVAQLR;SLSAIYLEK;SLVPAAELLESR;SMVEEGTGLR;SNAEDTLR;SQVEEELFSVR;SQVMDEATALQLR;SSIAGLLLK;SSSVGSSSSYPISPAVSR;TELATQEK;TPVEVPVGGFK;VAGMLMPRDQLR;VIKILITIVEEVETLRQER;VLADPSDDTK;VLALPEPSPAAPTLR;VPDVQDGVR;VPLDEALQR;VPVDVAYQR;VPVDVAYR;VQMEELSK;VSIYEAMR;VTKERMIIIIIEIIEK;YASGSSASLGGPESAVA 133 30.4 0 244.13 9.7777 13.2148 12.3326 11.0685 9.26402 10.7865 16.6198 16.4602 16.9022 16.6817 16.5209 11.3471 Q15149 PLEC_HUMAN Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 Homo sapiens (Human) actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion organization [GO:0007005]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization [GO:0008104]; protein-containing complex organization [GO:0043933]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060] axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] AAEEAEEAR;AGVAAPATQVAQVTLQSVQR;AGVVGPELHEQLLSAEK;AHAFAVQQK;ALAEEAKR;ALQALEELR;APVPASELLASGVLSR;AQAEAQQPTFDALRDELR;AQAEQAALR;AQAEVEGLGK;AQLEPVASPAK;AQVEQELTTLR;ASDSELER;ATTAALLLEAQAATGFLVDPVR;ATVSAPFGK;CQRCISELKDIR;DDGTGQLLLPLSDAR;DSQDAGGFGPEDR;DTHDQLSEPSEVR;DVGAYSK;EAEGQLQK;EAQAVPATLPELEATK;EGLTSIEEVTK;ELAEEAAR;ELAEQELEK;ELAQEQAR;ELQNAGDR;ELYQQLQRGERSVR;ESADPLGAWLQDAR;ESYSALMR;FAEQTLR;FLQEEAEK;FPVTDAVNK;GAEKAEVVETTQVYTEEETR;GAQEVGER;GGAEGELQALR;GGELVYTDSEAR;GIYQSLEGAVQAGQLK;GLIVREHGIR;GLKLTVEEAVRMGIVGPEFK;GRLCFEGLR;GTQGAEEVLR;GYFDEEMNR;GYLNKDTHDQLSEPSEVR;IISLETYNLLR;LAAEQELIR;LAAIGEATR;LAEQQRAEER;LAEVEAALEK;LAQGHTTVDELAR;LDLQYAK;LHVAILEREKQLR;LISLFQAMK;LLAAGKVPQRAGEVER;LLDAQLATGGIVDPR;LLDAQLSTGGIVDPSK;LLDPEDVDVPQPDEK;LLEAAAQSTK;LLFNDVQTLK;LLLWSQR;LQAEEAER;LQAEEAERR;LQAEEVAQQK;LQEAGILSAEELQR;LQLEATER;LRAETEQGEQQR;LSIYNALK;LSVAAQEAAR;LSYTQLLR;LTVNEAVK;LVASMEEAR;MQAVQEATR;MQEEVVR;MSAAQALK;MVEGYQGLR;NDDIADGNPK;NLLDEELQR;NLVDNITGQR;QAEEIGEK;QAEVELASR;QAQEEAER;QELEAELAK;QEQALLEEIER;QLAAEEER;QLAEAHAQAK;QLAEEDAAR;QLAEEDLAQQR;QLAEGTAQQR;QLQLAQEAAQK;QQEELLAEENQR;QQGLASYDYVR;QQQQMEQER;QSAEEQAQAR;QSSEAEIQAK;QTNLENLDQAFSVAER;QVAEEAAR;QVEEEILALK;QVEVTVHK;QVQDESQR;QVQVALETAQR;QYDIDDAIAK;REEAAVDAQQQK;RQQEELLAEENQR;SAEAELQSK;SALDQYR;SDEGQLSPATR;SIQEELQQLR;SLAQAEAEK;SLLAWQSLRRDVQLIR;SLQEEHVAVAQLR;SLSAIYLEK;SLVPAAELLESR;SMVEEGTGLR;SNAEDTLR;SQVEEELFSVR;SQVMDEATALQLR;SSIAGLLLK;SSSVGSSSSYPISPAVSR;TELATQEK;TPVEVPVGGFK;TSSEDNLYLAVLR;VIKILITIVEEVETLRQER;VLADPSDDTK;VLALPEPSPAAPTLR;VPDVQDGVR;VPLDEALQR;VPVDVAYQR;VPVDVAYR;VQMEELSK;VSIYEAMR;VTKERMIIIIIEIIEK;YASGSSASLGGPESAVA 132 31.2 0.8964 -0.23627 0 0 0 0 0 0 0 0 0 8.73958 0 0 Q15154 PCM1_HUMAN Pericentriolar material 1 protein (PCM-1) (hPCM-1) PCM1 Homo sapiens (Human) centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176] apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] DPQQEPMEEIENLKK;EKFYEAKLQQQQR;FGVESDK;ILARDPQQEPMEEIENLKK;LMAAKQK;NQLDTNGRRR;NSTQLKSR 7 3.2 0.97681 -4.8442 11.9044 13.2647 0 0 9.4936 8.28882 0 0 0 0 11.0057 0 Q15165 PON2_HUMAN Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2) PON2 Homo sapiens (Human) lactone catabolic process [GO:1901335]; response to toxic substance [GO:0009636] extracellular region [GO:0005576]; plasma membrane [GO:0005886] acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] GRLVAVGLLGIALALLGERLLALR;LVAVGLLGIALALLGERLLALR 2 6.8 0.71234 0.14822 0 0 3.60549 0 6.53683 0 0 0 0 6.77558 0 0 Q15166 PON3_HUMAN Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) PON3 Homo sapiens (Human) carboxylic acid catabolic process [GO:0046395]; establishment of localization in cell [GO:0051649]; lactone catabolic process [GO:1901335]; negative regulation of superoxide anion generation [GO:0032929]; regulation of cellular response to drug [GO:2001038]; renal sodium ion transport [GO:0003096]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] WTYVLFYSPREVKVVAK 1 4.8 0.85296 -0.080234 0 0 0 0 0 0 0 0 0 0 6.58097 0 Q15170 TCAL1_HUMAN Transcription elongation factor A protein-like 1 (TCEA-like protein 1) (Nuclear phosphoprotein p21/SIIR) (Transcription elongation factor S-II protein-like 1) TCEAL1 SIIR Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] ERLARSRPQFR 1 6.9 0.86475 -0.086624 0 0 0 6.90292 6.12288 0 0 0 0 0 0 0 Q15173 2A5B_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) PPP2R5B Homo sapiens (Human) cellular response to growth factor stimulus [GO:0071363]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] KQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLK;LQGTQGAKEAPLQR 2 10.7 0.88611 -0.1973 0 0 7.8031 0 0 7.75622 0 0 0 0 0 0 Q15181 IPYR_HUMAN Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) PPA1 IOPPP PP Homo sapiens (Human) phosphate-containing compound metabolic process [GO:0006796] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] AAPFSLEYR;GEIIGVK;SGFSTEER;YVANLFPYK 4 11.4 0.00489 1.5985 0 0 11.4042 0 0 9.18589 0 11.2786 12.1513 10.8489 0 0 Q15185 TEBP_HUMAN Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) PTGES3 P23 TEBP Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; cyclooxygenase pathway [GO:0019371]; fibroblast proliferation [GO:0048144]; glycogen biosynthetic process [GO:0005978]; lung saccule development [GO:0060430]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of telomere maintenance via telomerase [GO:0032212]; prostaglandin biosynthetic process [GO:0001516]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; signal transduction [GO:0007165]; skin development [GO:0043588]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; telomerase holoenzyme complex [GO:0005697]" DNA polymerase binding [GO:0070182]; Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082] DWEDDSDEDMSNFDR;GESGQSWPRLTKER;SILCCLR 3 22.5 0.93693 -0.52464 0 0 0 0 8.06948 0 0 3.54449 12.1286 0 0 9.71141 Q15198 PGFRL_HUMAN Platelet-derived growth factor receptor-like protein (PDGFR-like protein) (PDGF receptor beta-like tumor suppressor) PDGFRL PRLTS Homo sapiens (Human) extracellular region [GO:0005576] platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019] LSVKQNER;VTLHREFPAK 2 4.8 0.98065 -1.6762 0 0 0 0 8.69884 0 0 0 0 0 0 0 Q15208 STK38_HUMAN Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) STK38 NDR1 Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; postsynapse organization [GO:0099173]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; histone reader activity [GO:0140566]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin-like protein reader activity [GO:0140035]; UFM1-modified protein reader activity [GO:0141185] DIKPDNLLLDSK;ETEFLRLK;VIGRGAFGEVR;VTLENFYSNLIAQHEEREMRQK 4 11.4 0.98051 -1.6142 0 0 0 9.30257 0 0 0 0 0 0 11.3768 8.59656 Q15223 NECT1_HUMAN Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) NECTIN1 HVEC PRR1 PVRL1 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cochlea morphogenesis [GO:0090103]; desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of synapse assembly [GO:0051963]; retina development in camera-type eye [GO:0060041]; symbiont entry into host cell [GO:0046718] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone membrane [GO:0032584]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; virion binding [GO:0046790]; virus receptor activity [GO:0001618] AGPVPTAIIGGVAGSILLVLIVVGGIVVALRR;VGGPHPKYDEDAK 2 8.7 0.91539 -0.34002 0 0 0 0 0 0 0 10.2423 0 7.70867 0 0 Q15223 NECT1_HUMAN Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) NECTIN1 HVEC PRR1 PVRL1 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cochlea morphogenesis [GO:0090103]; desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of synapse assembly [GO:0051963]; retina development in camera-type eye [GO:0060041]; symbiont entry into host cell [GO:0046718] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone membrane [GO:0032584]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; virion binding [GO:0046790]; virus receptor activity [GO:0001618] QSSLVPEDIQVVHLDPGR 1 3.9 0.90428 -0.26889 0 0 0 0 9.68083 0 0 0 0 0 0 0 Q15233 NONO_HUMAN "Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)" NONO NRB54 Homo sapiens (Human) activation of innate immune response [GO:0002218]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; RNA splicing [GO:0008380] chromosome [GO:0005694]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] AVVIVDDR;FGQAATMEGIGAIGGTPPAFNR;GIVEFSGKPAAR;GTFPDAR;QQQDQVDRNIK;TLAEIAK;VELDNMPLR 7 16.1 0.89777 -0.23874 9.96554 11.677 9.78834 8.52881 8.47484 8.77824 0 0 11.4621 0 11.5539 0 Q15238 PSG5_HUMAN Pregnancy-specific beta-1-glycoprotein 5 (PS-beta-G-5) (PSBG-5) (Pregnancy-specific glycoprotein 5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3) PSG5 Homo sapiens (Human) female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] cell surface [GO:0009986]; extracellular region [GO:0005576] HRGLYTCSVRNSATGK;LPLLNPI 2 6.9 0.97479 -1.3924 0 0 0 0 9.70188 0 0 0 0 7.71685 0 0 Q15256 PTPRR_HUMAN Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) PTPRR ECPTP PTPRQ Homo sapiens (Human) ERBB2 signaling pathway [GO:0038128]; in utero embryonic development [GO:0001701]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" EKVAMEYLQSASRILTR;LSAETVQ;MKPIGLQERR;SLDIAPQKIYR 4 6.8 0.97443 -3.5045 0 0 0 0 0 0 0 0 0 10.8262 0 0 Q15257 PTPA_HUMAN "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" PTPA PPP2R4 Homo sapiens (Human) mitotic spindle organization [GO:0007052]; positive regulation of apoptotic process [GO:0043065] ATPase complex [GO:1904949]; calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; signaling receptor binding [GO:0005102] VSEMWNEVHEEK 1 3.4 0.89691 -0.23723 0 0 0 0 0 0 0 0 0 9.48361 0 0 Q15262 PTPRK_HUMAN Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IAGISAGILVFILLLLVVILIVK;QPAAFIVTQYPLPNTVK;TLKIAEIQARR;VVKIAGISAGILVFILLLLVVILIVK;VVKIAGISAGILVFILLLLVVILIVKK 5 3.8 0.96573 -1.2406 0 0 0 4.78717 0 8.51763 4.91241 0 5.1903 0 6.43653 5.74368 Q15269 PWP2_HUMAN Periodic tryptophan protein 2 homolog PWP2 PWP2H Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]" nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] AILMALR;EEEEEEEEDQEGDRETTIR;FEISCNLSLDAMEEFLNRRK;FVCIYHVR;TYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAER 5 9.9 0.97453 -2.4061 0 10.7349 10.2186 0 0 0 0 0 0 0 10.2863 0 Q15270 NKX11_HUMAN NK1 transcription factor-related protein 1 (Homeobox protein 153) (HPX-153) (Homeobox protein SAX-2) (NKX-1.1) NKX1-1 HPX153 SAX2 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RTGSDSKSGKPR 1 2.7 0.76957 0.0576 0 11.3129 0 0 0 0 0 0 0 0 0 0 Q15274 NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase) QPRT Homo sapiens (Human) NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; quinolinate catabolic process [GO:0034213] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514] EVAPVPK 1 2.4 0.90968 -0.31093 0 7.3077 0 0 0 0 0 0 0 0 0 0 Q15276 RABE1_HUMAN Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) RABEP1 RAB5EP RABPT5 RABPT5A Homo sapiens (Human) apoptotic process [GO:0006915]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; membrane fusion [GO:0061025]; protein localization to ciliary membrane [GO:1903441]; protein transport [GO:0015031]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803] ANDQFLESQRLLMR;AQEDAEKLR;AQQQLEQEFNQKR;AQQQLEQEFNQKRAK;ELYLAKEEDLK;QELEDFIK 6 6.6 0.97973 -2.0018 0 0 7.94034 7.89233 0 9.97298 0 0 0 0 9.62143 0 Q15283 RASA2_HUMAN Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m) RASA2 GAP1M RASGAP Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] EVRVLQSLR;KEDLCNHSGK 2 2.2 0.98051 -1.7953 0 0 0 0 0 0 0 0 0 0 0 9.17986 Q15286 RAB35_HUMAN Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C) RAB35 RAB1C RAY Homo sapiens (Human) antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482] cell projection membrane [GO:0031253]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] "GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ENVNVEEMFNCITELVLR;ILVGNKNDDPER 2 14.9 0.91356 -0.38675 11.4614 11.9646 0 0 0 0 0 0 12.1561 0 0 9.59783 Q15291 RBBP5_HUMAN Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) RBBP5 RBQ3 Homo sapiens (Human) DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815] histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976] VQYHPRDQNK 1 1.9 0.88122 -0.15777 0 0 0 0 0 0 0 11.3756 0 0 0 0 Q15293 RCN1_HUMAN Reticulocalbin-1 RCN1 RCN Homo sapiens (Human) camera-type eye development [GO:0043010]; in utero embryonic development [GO:0001701] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] calcium ion binding [GO:0005509] DLNKDGK;GRRLGLALGLLLALVLAPR;LGLALGLLLALVLAPRVLR;NKDEKLTK;RLGLALGLLLALVLAPR;RLGLALGLLLALVLAPRVLR;VLRAKPTVR;YIFDNVAK 8 15.4 0.98067 -1.6458 5.31223 2.66186 4.84167 9.34156 8.68471 3.57107 0 0 10.7236 9.71445 0 5.38515 Q15303 ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] ERBB4 HER4 Homo sapiens (Human) cardiac muscle tissue regeneration [GO:0061026]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to epidermal growth factor stimulus [GO:0071364]; central nervous system morphogenesis [GO:0021551]; embryonic pattern specification [GO:0009880]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; heart development [GO:0007507]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; olfactory bulb interneuron differentiation [GO:0021889]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; synapse assembly [GO:0007416] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; fibroblast growth factor receptor activity [GO:0005007]; GABA receptor binding [GO:0050811]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; neuregulin receptor activity [GO:0038131]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transcription cis-regulatory region binding [GO:0000976]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CWMIDADSRPKFKELAAEFSR;CYGPYVSDCCHR;VLGSGAFGTVYK 3 3.4 0.75946 0.070485 6.48278 0 0 0 0 0 0 0 8.20853 0 0 0 Q15306 IRF4_HUMAN Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) IRF4 MUM1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; defense response to protozoan [GO:0042832]; immune system process [GO:0002376]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T-helper cell differentiation [GO:0045622]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]" GVVLWMAPDGLYAKR;HAGKQDYNREEDAALFK 2 7.1 0.96558 -1.2583 0 0 0 0 0 0 0 14.7324 0 0 0 0 Q15311 RBP1_HUMAN "RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)" RALBP1 RLIP RLIP1 RLIP76 Homo sapiens (Human) chemotaxis [GO:0006935]; doxorubicin transport [GO:1900753]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein phosphorylation [GO:0001934]; receptor-mediated endocytosis [GO:0006898]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] DLSKEERLWEVQR;DLTAADVVKQWK 2 3.8 0.97523 -1.457 6.00668 0 0 0 0 0 0 0 0 0 0 10.8466 Q15326 ZMY11_HUMAN Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) ZMYND11 BRAM1 BS69 Homo sapiens (Human) chromatin organization [GO:0006325]; defense response to virus [GO:0051607]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of JNK cascade [GO:0046329]; regulation of signal transduction [GO:0009966]; regulation of transcription elongation by RNA polymerase II [GO:0034243] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] AIDLNKK;AVANMQGEMDRKCK;MKGFGFWPAK 3 5.1 0.95556 -0.85252 0 0 6.3721 0 0 0 0 0 0 0 0 11.9743 Q15327 ANKR1_HUMAN Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) ANKRD1 C193 CARP HA1A2 Homo sapiens (Human) "cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of DNA biosynthetic process [GO:2000279]; phospholipase C/protein kinase C signal transduction [GO:0141212]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of protein secretion [GO:0050714]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; I band [GO:0031674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; p53 binding [GO:0002039]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; titin binding [GO:0031432]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] SEKQREAELK;TLLAHPVTLGEQQWKSEKQR 2 7.8 0.97651 -2.2496 0 0 0 0 0 9.58197 0 0 0 0 0 0 Q15329 E2F5_HUMAN Transcription factor E2F5 (E2F-5) E2F5 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; cell projection organization [GO:0030030]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEIEDLELK;IYDITNVLEGIDLIEK;IYDITNVLEGIDLIEKKSK 3 8.1 0.89616 -0.24958 0 0 0 0 3.17725 8.1249 0 0 0 0 10.1217 0 Q15334 L2GL1_HUMAN Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) LLGL1 DLG4 HUGL HUGL1 Homo sapiens (Human) axonogenesis [GO:0007409]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein-containing complex assembly [GO:0065003]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593] adherens junction [GO:0005912]; axon [GO:0030424]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; early endosome membrane [GO:0031901]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198] VGCFDPYSDDPR 1 1.1 0.28744 0.25339 0 0 0 9.24731 0 0 0 0 0 0 0 0 Q15345 LRC41_HUMAN Leucine-rich repeat-containing protein 41 (Protein Muf1) LRRC41 MUF1 PP7759 Homo sapiens (Human) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] identical protein binding [GO:0042802] GTIDVSSDR;LLDSLRALSGQAGCR;RSTQESLTAGGTDLK 3 4.8 0.95186 -0.72386 0 9.20239 7.06835 0 10.6327 0 0 0 0 0 0 0 Q15349 KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) RPS6KA2 MAPKAPK1C RSK3 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EAIDHDKR;LHYAFQTEGK;LTAMQVLK;RHPFFVTIDWNTLYR;SSSLSRLEEEGVVKEIDISHHVK;YGQHPNIITLK 6 10.2 0.97477 -2.3986 8.52748 0 0 0 7.55597 0 12.3398 0 10.3875 8.78578 0 0 Q15349 KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) RPS6KA2 MAPKAPK1C RSK3 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EAIDHDKR;LHYAFQTEGK;LTAMQVLK;RHPFFVTIDWNTLYR;SDSAACK;YGQHPNIITLK 6 7.8 0.94146 -0.60275 0 0 0 0 0 0 0 0 0 0 9.9095 0 Q15361 TTF1_HUMAN Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) TTF1 Homo sapiens (Human) DNA-templated transcription termination [GO:0006353]; negative regulation of DNA replication [GO:0008156]; termination of RNA polymerase I transcription [GO:0006363] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] LHIGRNIARPWKLIYYR;LKMYHSLLGNDWK 2 3.3 0.90162 -0.26359 0 0 0 0 0 8.92348 0 0 0 5.91049 0 0 Q15363 TMED2_HUMAN Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) TMED2 RNP24 Homo sapiens (Human) allantois development [GO:1905069]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; chorion development [GO:0060717]; COPI coating of Golgi vesicle [GO:0048205]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; heart looping [GO:0001947]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; labyrinthine layer blood vessel development [GO:0060716]; maintenance of protein localization in organelle [GO:0072595]; maternal placenta development [GO:0001893]; multicellular organism growth [GO:0035264]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of SREBP signaling pathway [GO:2000638]; somite rostral/caudal axis specification [GO:0032525]; vesicle cargo loading [GO:0035459] COPI-coated vesicle [GO:0030137]; COPI-coated vesicle membrane [GO:0030663]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589] frizzled binding [GO:0005109]; smoothened binding [GO:0005119] AINDNTNSR 1 4.5 0.30238 0.25128 0 0 0 0 0 0 0 0 0 10.1639 0 0 Q15365 PCBP1_HUMAN Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) PCBP1 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] "cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]" ESTGAQVQVAGDMLPNSTER;IANPVEGSSGR;IITLTGPTNAIFK;IREESGAR;LVVPATQCGSLIGK;QGANINEIR;QMSGAQIK;QVTITGSAASISLAQYLINAR 8 29.2 0 33.433 13.2415 13.1576 12.7561 9.60949 10.3436 10.5854 12.874 13.039 11.6866 12.6321 13.0032 11.5907 Q15366 PCBP2_HUMAN Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) PCBP2 Homo sapiens (Human) chromatin looping [GO:0140588]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; IRES-dependent viral translational initiation [GO:0075522]; mRNA metabolic process [GO:0016071]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of defense response to virus [GO:0050687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357]; viral RNA genome replication [GO:0039694] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] enzyme binding [GO:0019899]; lncRNA binding [GO:0106222]; mRNA binding [GO:0003729]; promoter-enhancer loop anchoring activity [GO:0140585]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] ESTGAQVQVAGDMLPNSTER;IANPVEGSTDR;IITLAGPTNAIFK;LSSETGGMGSS;QMSGAQIK 5 17.3 0 5.1856 11.708 0 0 8.71077 9.24767 0 11.8124 11.9287 11.7148 10.3669 11.1734 11.1098 Q15370 ELOB_HUMAN Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) ELOB TCEB2 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; target-directed miRNA degradation [GO:0140958]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891] transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] ESSTVFELK 1 7.6 0.90969 -0.31566 0 0 0 0 0 0 0 0 0 0 0 10.1419 Q15375 EPHA7_HUMAN Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) EPHA7 EHK3 HEK11 Homo sapiens (Human) axon guidance [GO:0007411]; brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; ephrin receptor signaling pathway [GO:0048013]; modulation of chemical synaptic transmission [GO:0050804]; negative chemotaxis [GO:0050919]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of synapse assembly [GO:0051964]; nephric duct morphogenesis [GO:0072178]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of cell-cell adhesion [GO:0022407]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of postsynapse organization [GO:0099175]; regulation of protein autophosphorylation [GO:0031952]; retinal ganglion cell axon guidance [GO:0031290] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; chemorepellent activity [GO:0045499]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CECEDGYYR;TYSTVKTK 2 1.7 0.91729 -0.41189 0 0 2.99393 4.4614 0 4.07793 0 7.36265 0 9.16722 0 0 Q15382 RHEB_HUMAN GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) RHEB RHEB2 Homo sapiens (Human) cellular response to nutrient levels [GO:0031669]; negative regulation of cold-induced thermogenesis [GO:0120163]; oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell cycle [GO:0051726]; regulation of macroautophagy [GO:0016241]; regulation of type B pancreatic cell development [GO:2000074]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spliceosomal complex [GO:0005681] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] VISYEEGK;VQIPIMLVGNKK 2 10.9 0.91693 -0.41092 0 0 0 7.71925 0 0 0 0 0 0 0 8.80571 Q15386 UBE3C_HUMAN Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] proteasome complex [GO:0000502] ubiquitin protein ligase activity [GO:0061630] LLYAIECAAGFELS;LSPENEPDLK;RLIWLYQNLIK;RNFCPPNHWLSEQEDIK;WIQLFKVITNLVKMLK 5 6.3 0.96655 -1.2661 4.93353 0 0 0 7.87971 0 0 7.49809 0 0 0 0 Q15388 TOM20_HUMAN Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) TOMM20 KIAA0016 Homo sapiens (Human) "protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to muscle activity [GO:0014850]; tRNA import into mitochondrion [GO:0016031]" cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082] IVSAQSLAEDDVE 1 9 0.78273 0.022674 0 0 8.00804 0 0 0 9.39051 9.09677 0 0 0 9.89744 Q15389 ANGP1_HUMAN Angiopoietin-1 (ANG-1) ANGPT1 KIAA0003 Homo sapiens (Human) activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; cell-substrate adhesion [GO:0031589]; glomerulus vasculature development [GO:0072012]; hemopoiesis [GO:0030097]; heparin biosynthetic process [GO:0030210]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of vascular permeability [GO:0043116]; neuron apoptotic process [GO:0051402]; positive chemotaxis [GO:0050918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell adhesion [GO:0045785]; positive regulation of coagulation [GO:0050820]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor internalization [GO:0002092]; protein localization to cell surface [GO:0034394]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of macrophage migration inhibitory factor signaling pathway [GO:2000446]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of tumor necrosis factor production [GO:0032680]; sprouting angiogenesis [GO:0002040]; Tie signaling pathway [GO:0048014] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971] LNGIKWHYFK;LQHLEHVMENYTQWLQK 2 5.4 0.96446 -1.1739 0 0 0 0 0 9.90877 0 0 0 0 0 0 Q15390 MTFR1_HUMAN Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) MTFR1 CHPPR FAM54A2 KIAA0009 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] EKRANAGK;VLFGPHMLKPTGKMK 2 6.9 0.98035 -1.656 0 0 0 0 0 0 0 0 0 0 7.18893 0 Q15392 DHC24_HUMAN Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) DHCR24 KIAA0018 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of cell population proliferation [GO:0008285]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634] "delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]" DIQKQVREWK;EEFWEMFDGSLYHK;EEFWEMFDGSLYHKLREK;NIMINLMDILEVDTKK 4 8.5 0.91672 -0.42684 0 0 0 0 0 8.61655 0 9.24203 0 8.46675 6.55942 0 Q15392 DHC24_HUMAN Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) DHCR24 KIAA0018 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of cell population proliferation [GO:0008285]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634] "delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]" EEFWEMFDGSLYHK;EEFWEMFDGSLYHKLREK;GAGEQNR;NIMINLMDILEVDTKK 4 8.6 0.64559 0.17143 0 0 0 0 0 0 0 0 0 0 0 9.48543 Q15393 SF3B3_HUMAN Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) SF3B3 KIAA0017 SAP130 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] protein-containing complex binding [GO:0044877]; U2 snRNA binding [GO:0030620] ADKRVNEWK;FLAVGLVDNTVR;GLLNGASQK;ITLETDEDMVTEIR;IVPGQFLAVDPK;LTGGTKDYIVVGSDSGR;NFGDQPDIRCPIPR;QQEIVVSR;SYYFPVK;TPPEVSK;TPVEEVPAAIAPFQGR 11 10.3 0.95515 -0.88274 12.0769 10.861 11.4901 0 6.79442 10.8493 11.1635 12.6985 11.763 10.6285 9.57941 0 Q15397 PUM3_HUMAN Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8) PUM3 cPERP-C KIAA0020 PUF-A XTP5 Homo sapiens (Human) regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417] chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] EIIEVLQK;HSLVHKVFLDFFTYAPPK;KPKWDDFK;QIIISEIISSLPSIVNDK;VAKEGGPK 5 9.3 0.97422 -3.8023 0 0 0 0 0 0 9.71177 0 0 0 0 11.7493 Q15398 DLGP5_HUMAN Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) DLGAP5 DLG7 KIAA0008 Homo sapiens (Human) centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; regulation of mitotic cell cycle [GO:0007346]; signaling [GO:0023052] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] microtubule binding [GO:0008017] HFGLKDVNIPTLEGR;IAHRKSLSQK;VSDKEKK 3 3.8 0.97255 -2.8181 0 0 0 0 0 0 0 0 12.2962 0 9.66042 0 Q15399 TLR1_HUMAN Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354] "identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]" IQLSEESEFLVDR;IQYLDISVFK;SLLSLNMSSNILTDTIFR;VLDLHSNK 4 6.2 0.89942 -0.25855 10.1026 0 0 0 0 0 0 0 0 0 10.3349 9.07307 Q15404 RSU1_HUMAN Ras suppressor protein 1 (RSP-1) (Rsu-1) RSU1 RSP1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925] LKHLNLGMNRLNTLPR;LVEESREKNQPEVDMSDR 2 12.3 0.8808 -0.14897 0 5.63894 0 9.17468 0 0 0 0 0 8.11619 0 0 Q15406 NR6A1_HUMAN Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF) (hGCNF) (Retinoid receptor-related testis-specific receptor) (RTR) (hRTR) NR6A1 GCNF Homo sapiens (Human) gamete generation [GO:0007276]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LIYLYHK;LLKCLQMGMNRK 2 4 0.96828 -1.3245 0 0 0 9.63178 0 0 0 0 0 0 0 10.5026 Q15413 RYR3_HUMAN Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor) RYR3 HBRR Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to ATP [GO:0071318]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; cellular response to magnesium ion [GO:0071286]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; membrane [GO:0016020]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; intracellularly gated calcium channel activity [GO:0015278]; ryanodine-sensitive calcium-release channel activity [GO:0005219] EEQNFVIQNEINNLAFLTGDSKSK;EILNLLYKLLAALIRGNR;ELQGMVEVVAENYHNIWAKK;GRSLTKAQR;IAELLGLDK;ISWSGSNIR;LPETEKNYNLQMSTETLK;MMFNLLRRQYDSIGELLQALR;MSKAMQVKSGGQDQER;MVASCCRFLCYFCR;QLVLTVGLLAVVVYLYTVVAFNFFRK;RGDLYSIQTSLIVAALKK;SCQSGEDEEEDEDK;TVQEEEQLK 14 4.6 0.97499 -3.0794 0 5.69279 8.78047 6.48232 0 12.2108 0 10.5395 0 5.84197 0 8.16551 Q15417 CNN3_HUMAN "Calponin-3 (Calponin, acidic isoform)" CNN3 Homo sapiens (Human) actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calmodulin binding [GO:0005516] YAEKQTRR 1 2.4 0.96624 -1.2834 0 0 0 0 0 0 0 11.5807 0 0 0 0 Q15418 KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) RPS6KA1 MAPKAPK1A RSK1 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; hepatocyte proliferation [GO:0072574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of translation in response to stress [GO:0043555]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FTLSGGNWNTVSETAK;LHYAFQTEGK;LRLWALIPWLPRK;YGQHPNIITLK 4 6.7 0.84858 -0.06691 0 0 0 9.18866 2.92412 0 0 0 0 0 0 0 Q15424 SAFB1_HUMAN Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) SAFB HAP HET SAFB1 Homo sapiens (Human) chromatin organization [GO:0006325]; estrogen receptor signaling pathway [GO:0030520]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357] midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] EPAEQPGDGER;LSDLRVIDLRAELR;RDSDGKK;SVVSFDK;SWQGTADGGMMDRDHK;VIDLRAELR 6 6 0.97425 -2.4521 0 0 0 0 0 5.73528 0 0 8.29494 0 0 11.3857 Q15427 SF3B4_HUMAN Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) SF3B4 SAP49 Homo sapiens (Human) "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; splicing factor binding [GO:1990935] MAAGPISER 1 2.1 0.93666 -0.52665 0 5.79176 8.39326 0 0 0 0 0 0 0 0 6.46635 Q15428 SF3A2_HUMAN Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) SF3A2 SAP62 Homo sapiens (Human) "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of neuron projection development [GO:0010976]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AEGKFWTHWNRETK;DFQHRPGGK 2 5 0.9779 -1.9513 0 0 0 0 0 0 0 0 11.6217 0 0 0 Q15431 SYCP1_HUMAN Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8) SYCP1 SCP1 Homo sapiens (Human) cell division [GO:0051301]; chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; lateral element assembly [GO:0051878]; meiotic DNA repair synthesis [GO:0000711]; protein homotetramerization [GO:0051289]; reciprocal meiotic recombination [GO:0007131]; regulation of protein localization [GO:0032880]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] "autosome [GO:0030849]; central element [GO:0000801]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; male germ cell nucleus [GO:0001673]; synaptonemal complex [GO:0000795]; transverse filament [GO:0000802]" DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690] EETRQVYMDLNNNIEK;EVKDLKTELENEK;IQHLEQEYKKEINDK;QHHLTKELEDIK;QVENKNK;VLGEKETLLYENK 6 7.8 0.98067 -1.615 4.2555 0 0 9.23139 0 0 11.8234 0 8.38914 0 9.01447 0 Q15435 PP1R7_HUMAN Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) PPP1R7 SDS22 Homo sapiens (Human) chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] enzyme regulator activity [GO:0030234]; protein phosphatase regulator activity [GO:0019888] ELDLYDNQIK;KIENLEALTELEILDISFNLLR 2 8.9 0.8492 -0.070741 11.7797 0 0 0 0 0 0 0 6.69877 0 0 0 Q15436 SC23A_HUMAN Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) SEC23A Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; protein localization to plasma membrane [GO:0072659] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270] KSGYQDMPEYENFR;LAVSSAA;VPLTQATR 3 3.8 0.81515 -0.0025128 0 0 0 0 0 0 0 9.37193 10.1241 12.6781 12.5969 0 Q15437 SC23B_HUMAN Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) SEC23B Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270] QLIRLCQKFGQYNK;QTFQRIFTK 2 3 0.97496 -1.3836 0 5.11674 0 0 0 0 9.01561 0 0 9.91 0 0 Q15438 CYH1_HUMAN "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) establishment of epithelial cell polarity [GO:0090162]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cell adhesion [GO:0030155]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] DPFYEMLAARKK 1 3 0.7675 0.057317 0 0 0 0 8.32238 0 0 9.96852 0 0 0 0 Q15459 SF3A1_HUMAN Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) SF3A1 SAP114 Homo sapiens (Human) "mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] IGEEEIQKPEEK;IGLLDPR;NGPEFEAR;VSEFKEGKAQEPSAAIPK;WLEQRDRSIR 5 6.9 0.9648 -1.2266 0 0 0 6.53851 9.62804 0 0 9.93456 0 6.46102 0 10.8705 Q15465 SHH_HUMAN Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)] SHH Homo sapiens (Human) "alpha-beta T cell differentiation [GO:0046632]; androgen metabolic process [GO:0008209]; animal organ formation [GO:0048645]; apoptotic signaling pathway [GO:0097190]; artery development [GO:0060840]; axon guidance [GO:0007411]; Bergmann glial cell differentiation [GO:0060020]; blood coagulation [GO:0007596]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; branching morphogenesis of an epithelial tube [GO:0048754]; bud outgrowth involved in lung branching [GO:0060447]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; cell development [GO:0048468]; cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; cerebellar granule cell precursor proliferation [GO:0021930]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal system development [GO:0048706]; endocytosis [GO:0006897]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment of epithelial cell polarity [GO:0090162]; forebrain development [GO:0030900]; formation of anatomical boundary [GO:0048859]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; inner ear development [GO:0048839]; intein-mediated protein splicing [GO:0016539]; intermediate filament organization [GO:0045109]; left lung development [GO:0060459]; limb bud formation [GO:0060174]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; lymphoid progenitor cell differentiation [GO:0002320]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783]; metanephric collecting duct development [GO:0072205]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephros development [GO:0001656]; midbrain development [GO:0030901]; myoblast differentiation [GO:0045445]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of gene expression [GO:0010629]; negative regulation of kidney smooth muscle cell differentiation [GO:2000357]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of ureter smooth muscle cell differentiation [GO:2000062]; negative thymic T cell selection [GO:0045060]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; osteoblast development [GO:0002076]; pancreas development [GO:0031016]; pattern specification process [GO:0007389]; polarity specification of anterior/posterior axis [GO:0009949]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of kidney smooth muscle cell differentiation [GO:2000358]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sclerotome development [GO:0061189]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureter smooth muscle cell differentiation [GO:2000063]; positive regulation of Wnt signaling pathway [GO:0030177]; positive thymic T cell selection [GO:0045059]; primary prostatic bud elongation [GO:0060516]; prostate epithelial cord elongation [GO:0060523]; prostate gland development [GO:0030850]; protein autoprocessing [GO:0016540]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of glial cell proliferation [GO:0060251]; regulation of mesenchymal cell proliferation involved in prostate gland development [GO:0060782]; regulation of nodal signaling pathway [GO:1900107]; regulation of odontogenesis [GO:0042481]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to nucleus [GO:1900180]; regulation of proteolysis [GO:0030162]; regulation of stem cell proliferation [GO:0072091]; right lung development [GO:0060458]; roof of mouth development [GO:0060021]; salivary gland cavitation [GO:0060662]; self proteolysis [GO:0097264]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber differentiation [GO:0098528]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord motor neuron differentiation [GO:0021522]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell proliferation [GO:0042098]; telencephalon regionalization [GO:0021978]; thalamus development [GO:0021794]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea morphogenesis [GO:0060439]; tracheoesophageal septum formation [GO:1905327]; trunk neural crest cell migration [GO:0036484]; vasculogenesis [GO:0001570]; ventral midline development [GO:0007418]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; glycosaminoglycan binding [GO:0005539]; laminin-1 binding [GO:0043237]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270] LTPLAYKQFIPNVAEK;SKYGMLAR;TLGASGR;VLAADDQGRLLYSDFLTFLDR 4 11.3 0.97562 -2.3184 0 0 6.41078 0 9.62212 10.99 12.6722 0 0 0 0 0 Q15466 NR0B2_HUMAN Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner) NR0B2 SHP Homo sapiens (Human) animal organ regeneration [GO:0031100]; bile acid and bile salt transport [GO:0015721]; cholesterol metabolic process [GO:0008203]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to organic cyclic compound [GO:0014070] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] SRCLCRQHRPVQLCAPHR 1 7 0.51066 0.18764 0 0 10.8675 0 0 0 0 0 0 6.88509 0 0 Q15468 STIL_HUMAN SCL-interrupting locus protein (TAL-1-interrupting locus protein) STIL SIL Homo sapiens (Human) centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; microtubule organizing center organization [GO:0031023]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224] cell cortex [GO:0005938]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; procentriole replication complex [GO:0120099] identical protein binding [GO:0042802] ALQCHICSK;CELSAESQNAETEFFSK;DSLDCGKLLSLRVHITSR;EPIYPFARPQMNTR 4 4.5 0.50419 0.18811 7.92017 0 0 0 0 8.11088 0 6.67539 0 0 0 6.50597 Q15475 SIX1_HUMAN Homeobox protein SIX1 (Sine oculis homeobox homolog 1) SIX1 Homo sapiens (Human) "aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cochlea morphogenesis [GO:0090103]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; endothelin receptor signaling pathway [GO:0086100]; epithelial cell differentiation [GO:0030855]; facial nerve morphogenesis [GO:0021610]; fungiform papilla morphogenesis [GO:0061197]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal cell proliferation involved in ureter development [GO:0072198]; mesonephric tubule formation [GO:0072172]; metanephric mesenchyme development [GO:0072075]; middle ear morphogenesis [GO:0042474]; myoblast migration [GO:0051451]; myoblast proliferation [GO:0051450]; myotome development [GO:0061055]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory placode formation [GO:0030910]; organ induction [GO:0001759]; otic vesicle development [GO:0071599]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trigeminal ganglion development [GO:0061551]; ureter smooth muscle cell differentiation [GO:0072193]; ureteric bud development [GO:0001657]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]" AVVAFHR;GVLREWYAHNPYPSPREK;TIWDGEETSYCFKEK 3 14.1 0.95276 -0.75839 0 0 0 8.90848 0 0 8.02752 9.67848 0 9.11429 0 0 Q15477 SKI2_HUMAN Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) SKIC2 DDX13 SKI2W SKIV2 SKIV2L W Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]" cytosol [GO:0005829]; nucleus [GO:0005634]; Ski complex [GO:0055087] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FPAQYLK;ILEDFSKR;LTYTMILNLLRVDALR;MSKHAQTFGAK;QIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSR;QLPQVLHMSELLNR 6 7.5 0.97212 -2.6956 10.372 0 0 0 0 0 7.51523 11.1774 11.7184 0 0 0 Q15506 SP17_HUMAN Sperm surface protein Sp17 (Cancer/testis antigen 22) (CT22) (Sp17-1) (Sperm autoantigenic protein 17) (Sperm protein 17) SPA17 SP17 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228] calmodulin binding [GO:0005516] KMKTNSLQNEEK;SIPFSNTHYR 2 14.6 0.96505 -1.2505 0 0 0 0 0 8.29352 0 0 0 0 0 11.3592 Q15526 SURF1_HUMAN Surfeit locus protein 1 SURF1 SURF-1 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; respiratory chain complex IV assembly [GO:0008535] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803] cytochrome-c oxidase activity [GO:0004129] SVLRVSPRPGVAWRPSR 1 5.7 0.82307 -0.018463 0 0 0 0 0 7.1916 0 0 0 0 0 0 Q15527 SURF2_HUMAN Surfeit locus protein 2 (Surf-2) SURF2 Homo sapiens (Human) nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] LPELQVYTRGKK 1 4.7 0.77031 0.056218 0 0 0 0 0 0 0 0 0 6.9404 0 0 Q15542 TAF5_HUMAN Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100) TAF5 TAF2D Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] identical protein binding [GO:0042802]; RNA polymerase II general transcription initiation factor activity [GO:0016251] AALAEEQTEVAVK;GHNYPVWDTQFSPYGYYFVSGGHDRVAR;QTLLAVLQFLRQSKLR 3 7.1 0.98054 -2.0353 0 0 0 0 0 0 0 11.7523 0 3.70786 0 0 Q15545 TAF7_HUMAN Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) TAF7 TAF2F TAFII55 Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; estrogen receptor signaling pathway [GO:0030520]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class I biosynthetic process [GO:0045344]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermine transport [GO:0000296]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription regulator complex [GO:0005667] DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription cis-regulatory region binding [GO:0000976] FQAVLDELK;QIDNMKGKLQETQDR 2 6.9 0.69292 0.16223 0 0 5.99118 0 0 0 0 0 0 6.8695 0 0 Q15555 MARE2_HUMAN Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) MAPRE2 RP1 Homo sapiens (Human) cell division [GO:0051301]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; focal adhesion [GO:0005925]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901] CPVSQRNSSFQQPGR;GRFQDNLDFIQWFK;LALEGVEKER 3 12.4 0.97302 -2.8745 0 0 0 0 0 0 0 0 0 0 12.447 0 Q15561 TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) TEAD4 RTEF1 TCF13L1 TEF3 Homo sapiens (Human) cell fate specification [GO:0001708]; DNA-templated transcription [GO:0006351]; embryo implantation [GO:0007566]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; muscle organ development [GO:0007517]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; trophectodermal cell fate commitment [GO:0001830] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KAREIQAK;NELIARYIK 2 3.9 0.96501 -1.2533 0 0 0 0 12.8729 0 0 0 0 0 0 0 Q15562 TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) TEAD2 TEF4 Homo sapiens (Human) cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667] "disordered domain specific binding [GO:0097718]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]" GAQHHIYR;NELIARYIK 2 3.8 0.93668 -0.54969 0 0 0 0 0 0 10.3825 0 0 0 0 0 Q15569 TESK1_HUMAN Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) TESK1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; establishment of vesicle localization [GO:0051650]; negative regulation of cilium assembly [GO:1902018]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; podocyte cell migration [GO:0090521]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; spermatogenesis [GO:0007283]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] GVFHRDLTSK 1 1.6 0.98188 -1.5825 0 0 0 0 0 0 0 0 0 0 0 13.1579 Q15572 TAF1C_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) TAF1C Homo sapiens (Human) transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181] IDSLPAFPLLEPK;IQWRLQER;LGEAWAGR;LSERLGEAWAGR;SGAVCLWSPEDGLRQIYR 5 5.9 0.97217 -2.7228 14.4779 0 13.7794 0 0 0 8.10219 0 0 9.81152 0 0 Q15573 TAF1A_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) TAF1A Homo sapiens (Human) transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366] microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] DNA binding [GO:0003677] ESFNTFANR;IPGVWDPFVK;LDKDDYAYNAVAQDVFNHSWK;YLKNILMGNHLAWVQEEWNSR 4 18.2 0.96366 -1.2028 0 0 8.04314 0 0 3.85579 0 0 0 0 0 0 Q15582 BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI BIGH3 Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178] ALFVRLLALALALALGPAATLAGPAK;LAPVYQKLLERMK;LLERMKH;SLQGDKLEVSLK;SPYQLVLQHSRLR 5 9.5 0.95532 -0.97803 0 6.64674 8.79604 0 6.54686 0 0 0 0 0 7.23592 0 Q15596 NCOA2_HUMAN Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) NCOA2 BHLHE75 SRC2 TIF2 Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]; response to progesterone [GO:0032570] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] aryl hydrocarbon receptor binding [GO:0017162]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; transcription coactivator activity [GO:0003713] CIQKFHAQHEGESVSYAKR;DIGLPEITPK;HKILHRLLQDSSSPVDLAK 3 3.3 0.085039 0.39137 0 0 0 0 8.36181 0 8.75706 6.03683 0 0 0 0 Q15599 NHRF2_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) NHERF2 SLC9A3R2 Homo sapiens (Human) protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003] apical plasma membrane [GO:0016324]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800] ELRPRLCHLR 1 3 0.92175 -0.44312 5.14294 0 0 0 0 0 0 0 0 0 0 0 Q155Q3 DIXC1_HUMAN Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) DIXDC1 CCD1 KIAA1735 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507] cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; stress fiber [GO:0001725] actin binding [GO:0003779]; gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904] EGNHRYHFK;GATSVSNRGTSDLQLVR;KRPAVKPVQDLRQDLR;QELLRANMDK;SESIITQSEEKADFVIIPAEGIENR;SPRTQVGSEYRESWPPNSK;VLYFTDR 7 15.1 0.44265 0.19431 0 0 0 0 0 0 0 0 0 0 8.09366 0 Q155Q3 DIXC1_HUMAN Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) DIXDC1 CCD1 KIAA1735 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507] cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; stress fiber [GO:0001725] actin binding [GO:0003779]; gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904] EGNHRYHFK;GATSVSNRGTSDLQLVR;MGGTQVK;QELLRANMDK;SESIITQSEEKADFVIIPAEGIENR;SPRTQVGSEYRESWPPNSK;VLYFTDR 7 19.9 0.97528 -3.2975 0 0 0 8.99645 9.92229 6.50879 8.17503 0 9.53136 6.41115 8.37143 0 Q15615 OR4D1_HUMAN Olfactory receptor 4D1 (Olfactory receptor 4D3) (Olfactory receptor TPCR16) OR4D1 OR4D3 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CLVICRE 1 2.3 0.92993 -0.46925 0 0 0 0 0 0 0 10.0649 0 0 0 0 Q15617 OR8G1_HUMAN Olfactory receptor 8G1 (Olfactory receptor OR11-281) (Olfactory receptor TPCR25) OR8G1 OR8G1P Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LSCSSIYVNK 1 3.2 0.77568 0.044769 0 0 0 0 0 8.78898 0 0 0 0 0 0 Q15628 TRADD_HUMAN Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) TRADD Homo sapiens (Human) apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of hair follicle development [GO:0051798]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947] death domain binding [GO:0070513]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; tumor necrosis factor receptor binding [GO:0005164] KVGRSLQR;SVGLKWRK 2 4.8 0.97337 -2.558 0 0 0 0 0 0 0 0 0 0 0 13.9725 Q15629 TRAM1_HUMAN Translocating chain-associated membrane protein 1 (Protein TRAM1) TRAM1 TRAM Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] signaling receptor activity [GO:0038023] LFYFSNEK 1 2.1 0.91391 -0.39033 8.71036 0 0 0 0 0 0 0 0 0 0 0 Q15633 TRBP2_HUMAN RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) TARBP2 TRBP Homo sapiens (Human) global gene silencing by mRNA cleavage [GO:0098795]; miRNA processing [GO:0035196]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; regulation of miRNA processing [GO:1903798]; regulation of regulatory ncRNA processing [GO:0070920]; regulation of siRNA processing [GO:0070921]; regulation of translation [GO:0006417]; regulation of viral transcription [GO:0046782]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; pre-mRNA binding [GO:0036002]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; siRNA binding [GO:0035197] ALQYLKIMAGSK;GWRLPEYTVTQESGPAHRK;MLAANPGK 3 11.3 0.98112 -1.5916 0 0 0 0 0 0 9.71565 0 0 0 9.72149 6.78175 Q15637 SF01_HUMAN Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) SF1 ZFM1 ZNF162 Homo sapiens (Human) "Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nuclear body organization [GO:0030575]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of steroid biosynthetic process [GO:0050810]; spliceosomal complex assembly [GO:0000245]" nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] ATGANATPLDFPSK;EQERAYIVQLQIEDLTR;LNGTLREDDNR;NIEKECNAK;SVPGKYACGLWGLSPASR 5 12.1 0.91552 -0.33941 0 0 11.1358 0 0 9.56818 8.1979 0 9.63125 0 8.18264 0 Q15642 CIP4_HUMAN Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) TRIP10 CIP4 STOT STP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell communication [GO:0007154]; endocytosis [GO:0006897]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891] identical protein binding [GO:0042802]; lipid binding [GO:0008289] KMKDVYEK;TVVTEDFSHLPPEQQRK;YVKFVKER 3 5.6 0.97299 -2.8479 0 0 0 0 0 0 0 10.31 10.6753 0 0 0 Q15643 TRIPB_HUMAN Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) cartilage development [GO:0051216]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; inner ear receptor cell stereocilium organization [GO:0060122]; protein glycosylation [GO:0006486]; protein transmembrane transport [GO:0071806]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]; vesicle tethering to Golgi [GO:0099041] cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133] small GTPase binding [GO:0031267]; transcription coactivator activity [GO:0003713] DTAESRSGR;HREELSDYEER;IIREKDIEIDALSQK;KDMEIAELKK;KNIEQMDTDHKETK;LSTRFESSGQDMFR;NIEQMDTDHK;NLKQNLSELEQLNENLKK;QDLNDEKK;QEMLDDVQKK;SQESNVSIQKENLELK;TVVFQQERDQVMLALKQK 12 7.2 0.97314 -1.3764 10.7106 12.5884 0 0 11.4016 10.2353 10.8222 9.14888 0 12.4499 0 0 Q15648 MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 Homo sapiens (Human) androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G0 to G1 transition [GO:0045023]; hematopoietic stem cell differentiation [GO:0060218]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein import into nucleus [GO:0006606]; protein ubiquitination [GO:0016567]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; RNA polymerase II preinitiation complex assembly [GO:0051123]; thyroid hormone generation [GO:0006590]; thyroid hormone receptor signaling pathway [GO:0002154]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; peroxisome proliferator activated receptor binding [GO:0042975]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] GLSDALICTDDFIAKVVQR;MKAQGETEESEK;VTSLPAMTDR 3 2.6 0.97478 -1.4277 0 0 0 9.61084 0 0 0 0 11.9924 0 0 0 Q15649 ZNHI3_HUMAN Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3) ZNHIT3 TRIP3 Homo sapiens (Human) "box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of DNA-templated transcription [GO:0006355]; snoRNA localization [GO:0048254]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761] metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966] QLMVNLDQGEDKAKLMR 1 11 0.48387 0.19014 0 0 0 0 0 0 0 0 0 0 0 10.2242 Q15650 TRIP4_HUMAN Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) TRIP4 RQT4 Homo sapiens (Human) estrogen receptor signaling pathway [GO:0030520]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RQC-trigger complex [GO:0180022] histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270] GQFIEELITK 1 1.7 0.93627 -0.53384 0 0 0 0 9.83977 0 0 0 0 0 0 0 Q15652 JHD2C_HUMAN Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) JMJD1C JHDM2C KIAA1380 TRIP8 Homo sapiens (Human) blood coagulation [GO:0007596]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coregulator activity [GO:0003712] DLLTTTAGK;EEREQDNSESPNGR;HFVDPVLNQLQRPPQETGERLNK;IHEDEVEDMEEN;KGEEPAHSPVFCR;SAKERSK;SVSDLYK 7 3.3 0.97261 -2.7542 0 0 4.24891 0 0 0 10.8631 6.1319 0 8.16646 0 8.44766 Q15654 TRIP6_HUMAN Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) TRIP6 OIP1 Homo sapiens (Human) chordate embryonic development [GO:0043009]; focal adhesion assembly [GO:0048041]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA binding [GO:0003723] AYHPGCFTCVVCHR;CEECGLLLSSEGECQGCYPLDGHILCKACSAWR 2 9.9 0.95237 -0.74001 0 0 0 0 0 0 4.17576 0 0 0 0 0 Q15669 RHOH_HUMAN Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein) RHOH ARHH TTF Homo sapiens (Human) actin filament organization [GO:0007015]; mast cell activation [GO:0045576]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of T cell differentiation [GO:0045582]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase inhibitor activity [GO:0005095]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] LAQDVRAK 1 4.2 0.97372 -1.406 0 0 12.835 0 0 0 0 0 0 0 0 0 Q15678 PTN14_HUMAN Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) PTPN14 PEZ PTPD2 Homo sapiens (Human) lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712]" HSSATYGKFK;IPNKPPPEYPGPR;QDQASLPPAMAR;YNVLSKNCFVTR 4 4 0.95833 -1.0027 0 0 7.98413 0 0 0 0 0 10.7297 0 9.26127 0 Q15691 MARE1_HUMAN Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) MAPRE1 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; negative regulation of microtubule polymerization [GO:0031115]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]; protein localization [GO:0008104]; protein localization to astral microtubule [GO:1902888]; protein localization to centrosome [GO:0071539]; protein localization to microtubule [GO:0035372]; protein localization to mitotic spindle [GO:1902480]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] cell projection membrane [GO:0031253]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule end [GO:1905721]; mitotic spindle microtubule [GO:1990498]; mitotic spindle pole [GO:0097431]; spindle midzone [GO:0051233] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] AGPGVVR;AVNVYSTSVTSDNLSR;KPLTSSSAAPQRPISTQR;QGQETAVAPSLVAPALNKPK 4 22.8 0 17.721 9.06999 9.13556 8.62779 8.77446 6.2389 8.77726 8.21902 8.802 11.8368 10.3838 11.4538 8.32089 Q15695 U2AFL_HUMAN "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1)" ZRSR2P1 U2AF1-RS1 U2AF1L1 U2AF1P U2AF1RS1 U2AFBPL ZRSR1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628] KHNFPTSSPTLLIK;LHEEWLLREQKAQEEFR;SSHRGKK 3 7.9 0.24282 0.28793 0 0 0 0 0 8.39421 0 10.0161 10.1017 7.63401 0 9.15048 Q15696 U2AFM_HUMAN "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)" ZRSR2 U2AF1-RS2 U2AF1L2 U2AF1RS2 URP Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2AF complex [GO:0089701] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628] ERMGHHDDYYSR;KHNFPTSSPTLLIK;LHEEWLLREQKAQEEFR 3 8.9 0.92403 -0.44867 0 0 0 0 0 0 0 0 0 0 0 6.64249 Q15697 ZN174_HUMAN Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) ZNF174 ZSCAN8 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" MEITLSSNTEASSKQERHIIAK;TDPNMATDELPCK 2 15 0.76978 0.055745 0 8.11161 0 10.8546 0 0 0 0 0 0 0 0 Q15699 ALX1_HUMAN ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) ALX1 CART1 Homo sapiens (Human) embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GMQEKGELDELGDK 1 4.3 0.88214 -0.16231 0 0 9.83756 0 0 0 0 0 0 0 0 0 Q15700 DLG2_HUMAN Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) DLG2 Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nervous system development [GO:0007399]; protein localization to synapse [GO:0035418]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde axonal protein transport [GO:0099642] adherens junction [GO:0005912]; axon cytoplasm [GO:1904115]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] guanylate kinase activity [GO:0004385]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901] LTEEQAK;RRPILETVVEIKLFK 2 2.5 0.87608 -0.12263 0 0 0 0 0 0 0 0 0 10.3359 14.6118 0 Q15717 ELAV1_HUMAN ELAV-like protein 1 (Hu-antigen R) (HuR) ELAVL1 HUR Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; mRNA destabilization [GO:0061157]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein import into nucleus [GO:0006606]; regulation of stem cell population maintenance [GO:2000036] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; sarcoplasm [GO:0016528] double-stranded RNA binding [GO:0003725]; lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] AINTLNGLR;SLFSSIGEVESAK;SNGYEDHMAEDCR;VLVDQTTGLSR 4 14.1 0 3.9872 10.793 10.8495 10.5249 0 0 0 12.1669 12.1725 12.2693 0 9.86643 10.6723 Q15722 LT4R1_HUMAN Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; muscle contraction [GO:0006936]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]; nucleotide binding [GO:0000166] SLAVARPFVSQKLRTK 1 4.5 0.85044 -0.075545 0 0 0 8.16561 7.81807 0 0 0 0 0 0 0 Q15723 ELF2_HUMAN ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) ELF2 NERF Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AVSKLWGKHK;SPTTTASVSATAAPR 2 4.2 0.92829 -0.46 0 0 0 0 0 0 0 10.8546 0 0 0 0 Q15735 PI5PA_HUMAN "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56)" INPP5J PIB5PA PIPP Homo sapiens (Human) inositol phosphate metabolic process [GO:0043647]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]" DYVAYVWAK;TGLGGYWGNKGGVSVR 2 2.5 0.91485 -0.33094 0 0 9.36746 0 0 7.72096 0 0 0 0 0 0 Q15738 NSDHL_HUMAN "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)" NSDHL H105E3 Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; cholesterol metabolic process [GO:0008203]; hair follicle development [GO:0001942]; labyrinthine layer blood vessel development [GO:0060716]; smoothened signaling pathway [GO:0007224] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity [GO:0102175]; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [GO:0000252]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" EPAVSEPMRDQVAR;FVIGNGK;VNQNQAK 3 7.5 0.92111 -0.44458 0 0 0 0 0 0 11.8689 12.3844 0 0 10.9064 0 Q15742 NAB2_HUMAN NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) NAB2 MADER Homo sapiens (Human) endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037] nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] QLSLHEASP;SVGHIFEMDDNDSQKEEEIR 2 9 0.95507 -0.97442 0 0 0 0 0 0 10.3825 0 0 0 6.61758 0 Q15744 CEBPE_HUMAN CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) CEBPE Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; myeloid cell differentiation [GO:0030099]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLEYMAENER 1 3.6 0.93696 -0.56166 0 0 0 0 0 0 0 0 0 0 0 9.7937 Q15746 MYLK_HUMAN "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; regulation of synaptic vesicle endocytosis [GO:1900242]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820] actin cytoskeleton [GO:0015629]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; synapse [GO:0045202] actin binding [GO:0003779]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; myosin light chain kinase activity [GO:0004687]; scaffold protein binding [GO:0097110] IEGYPDPEVVWFKDDQSIRESR;LSKDRMK;NDVNCKR;QEGSIEVYEDAGSHYLCLLKARTR;STSFNVQDLLPDHEYKFRVR;TVSEEER;TVSEEERK 7 4.6 0.97312 -2.5919 12.6755 0 0 0 0 0 0 11.0041 6.91791 0 0 9.57465 Q15750 TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 Homo sapiens (Human) aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; nuclear speck [GO:0016607]; protein-containing complex [GO:0032991] mitogen-activated protein kinase p38 binding [GO:0048273]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877] LSQLGLDAGK 1 2 0.8981 -0.23243 0 0 0 0 0 0 0 0 0 0 0 10.8991 Q15751 HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) HERC1 Homo sapiens (Human) autophagy [GO:0006914]; cerebellar Purkinje cell differentiation [GO:0021702]; corpus callosum development [GO:0022038]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; ubiquitin-protein transferase activity [GO:0004842] AIEYRLHEMDR;CSSGIPLVGNLRTR;CVHKQTGR;DNQTTLQTLADMGGDLRK;EHEVMTAGK;FLGILMGVAIR;GVTIPNSGADTLGRR;LEAHQNR;LGHGNSDRQR;LIEELAATR;LLVLQRVFYALSNK;LVHTSPNYR;SFLERYCDK;SIGKTMVQGK;VDSSGETEKK;VGGRCVHKQTGR;VRSRLLACK;YLAMKTKSK 18 3.8 0.97866 -10.115 7.33342 0 9.7912 9.92148 3.21974 0 12.872 8.93723 12.3536 8.65617 0 12.7614 Q15758 AAAT_HUMAN Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) SLC1A5 ASCT2 M7V1 RDR RDRC Homo sapiens (Human) amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104] basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618] LGPEGELLIR;NIFPSNLVSAAFR;SELPLDPLPVPTEEGNPLLK;STEPELIQVK 4 9.8 0 3.3143 11.4771 0 0 8.68961 8.41346 8.1534 9.65744 11.3601 9.22636 7.00023 6.95489 0 Q15758 AAAT_HUMAN Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) SLC1A5 ASCT2 M7V1 RDR RDRC Homo sapiens (Human) amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104] basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618] LGPEGELLIR;NILGLVVFAIVFGVALRK;SELPLDPLPVPTEEGNPLLK;STEPELIQVK 4 18.5 0.6486 0.17107 0 0 0 0 0 4.68588 0 0 0 0 0 0 Q15759 MK11_HUMAN Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) MAPK11 PRKM11 SAPK2 SAPK2B Homo sapiens (Human) bone development [GO:0060348]; cardiac muscle cell proliferation [GO:0060038]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV-B [GO:0071493]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; osteoblast differentiation [GO:0001649]; p38MAPK cascade [GO:0038066]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] MLVLDSDQR 1 2.5 0.91009 -0.31529 0 0 0 0 8.36641 0 0 0 0 0 0 0 Q15760 GPR19_HUMAN Probable G-protein coupled receptor 19 (GPR-NGA) GPR19 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] cilium [GO:0005929]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] SSLVFTAITWISFSSSASKPTLYSIYNANFRR;TITKDSIYDSFDR 2 10.8 0.41376 0.20287 0 0 0 0 0 0 0 7.80465 0 0 8.44783 0 Q15772 SPEG_HUMAN Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) SPEG APEG1 KIAA1297 Homo sapiens (Human) muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGQGPFSNSSEK;FAEEAEGGLCR;FAQELGR;GVQHIFRVLSTTVK;RLSDFYDIHQEIGRGAFSYLR;SLEQPKSER;SPFYEPDPQETEARIVGGR;VTVQSLSPAK;WGFSRPRKDK 9 3.5 0.97569 -5.1407 0 0 7.70252 9.79211 7.23439 3.49557 0 2.72045 0 9.86242 0 0 Q15776 ZKSC8_HUMAN Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) ZKSCAN8 ZNF192 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GLEHEEAR 1 1.4 0.93379 -0.51084 0 0 0 0 0 0 0 0 0 9.58037 0 0 Q15777 MPPD2_HUMAN Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2) MPPED2 C11orf8 FAM1B Homo sapiens (Human) AMP binding [GO:0016208]; GMP binding [GO:0019002]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081] QDYYRFPSVSK 1 4 0.97714 -1.523 0 0 0 0 0 0 0 0 0 0 0 11.3209 Q15784 NDF2_HUMAN Neurogenic differentiation factor 2 (NeuroD2) (Class A basic helix-loop-helix protein 1) (bHLHa1) (NeuroD-related factor) (NDRF) NEUROD2 BHLHA1 NDRF Homo sapiens (Human) associative learning [GO:0008306]; axon development [GO:0061564]; behavioral fear response [GO:0001662]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cerebellar cortex development [GO:0021695]; negative regulation of synapse maturation [GO:2000297]; nervous system development [GO:0007399]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; sequence-specific double-stranded DNA binding [GO:1990837]" FASWGDGEDDEPR 1 3.4 0.80798 0.011404 0 0 0 0 0 0 0 0 0 4.19999 0 0 Q15785 TOM34_HUMAN Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) TOMM34 URCC3 Homo sapiens (Human) protein targeting to mitochondrion [GO:0006626] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] heat shock protein binding [GO:0031072] ASAYEALEK;DYKSSFADISNLLQIEPR 2 8.7 0.95064 -0.66721 4.77689 0 0 0 0 0 0 0 0 0 0 0 Q15788 NCOA1_HUMAN Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) NCOA1 BHLHE74 SRC1 Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrogen receptor signaling pathway [GO:0030520]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; mRNA transcription by RNA polymerase II [GO:0042789]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; progesterone receptor signaling pathway [GO:0050847]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of thyroid hormone receptor signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713] IISIDTSSLRAAGR;MDGAVTSVTIK;STPNLSLDDVKVK;TVDQIQLMK 4 3.3 0.98079 -1.6734 0 0 0 0 9.06143 8.57871 0 10.9438 0 10.3745 0 0 Q15797 SMAD1_HUMAN Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) SMAD1 BSP1 MADH1 MADR1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle cell proliferation [GO:0060038]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; DNA-templated transcription [GO:0006351]; embryonic pattern specification [GO:0009880]; gamete generation [GO:0007276]; hindbrain development [GO:0030902]; homeostatic process [GO:0042592]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; mesodermal cell fate commitment [GO:0001710]; midbrain development [GO:0030901]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell differentiation [GO:0051148]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of cartilage development [GO:0061036]; positive regulation of dendrite development [GO:1900006]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary miRNA processing [GO:0031053]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141] "co-SMAD binding [GO:0070410]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]" FVLLFFPFLFLVLPPVLVPR 1 14.6 0.90914 -0.30877 0 0 0 0 0 0 0 0 0 8.27235 0 0 Q15811 ITSN1_HUMAN Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064] DQLDEVEKETRSK;ENFERGNLELEK;LYKAKSNK;SHGKSNPYCEVTMGSQCHITK;TIQDTLNPK 5 3.7 0.97431 -2.4495 0 0 0 0 0 0 0 0 0 10.5477 0 8.32229 Q15813 TBCE_HUMAN Tubulin-specific chaperone E (Tubulin-folding cofactor E) TBCE Homo sapiens (Human) adult locomotory behavior [GO:0008344]; developmental growth [GO:0048589]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; muscle atrophy [GO:0014889]; peripheral nervous system neuron axonogenesis [GO:0048936]; post-chaperonin tubulin folding pathway [GO:0007023]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; microtubule [GO:0005874] alpha-tubulin binding [GO:0043014]; protein-folding chaperone binding [GO:0051087] LSEEFLTAHPR;QAGGHKDPEK 2 4 0.95405 -0.92031 0 0 0 0 0 0 10.7665 0 0 0 8.42105 0 Q15818 NPTX1_HUMAN Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I) NPTX1 Homo sapiens (Human) axonogenesis involved in innervation [GO:0060385]; cellular response to glucose stimulus [GO:0071333]; cellular response to potassium ion [GO:0035865]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial transport [GO:0006839]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107] endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083]; transport vesicle [GO:0030133] metal ion binding [GO:0046872] ISELEKGQK;KQPGSGKNTMGDLSR;TPAAETLSQLGQTLQSLKTRLENLEQYSR 3 12.3 0.96729 -1.306 3.45141 0 0 0 0 0 0 12.205 0 0 0 0 Q15822 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; cellular response to nicotine [GO:0071316]; membrane depolarization [GO:0051899]; modulation of inhibitory postsynaptic potential [GO:0098828]; monoatomic ion transport [GO:0006811]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection cytoplasm [GO:0120111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; quaternary ammonium group binding [GO:0050997] QEWSDYKLR 1 1.7 0.97751 -1.522 0 0 0 0 0 0 0 0 0 10.6073 0 0 Q15825 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Homo sapiens (Human) "acetylcholine receptor signaling pathway [GO:0095500]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] ECFHCHK;EVEDDWK;EVEDDWKYVAMVVDR 3 4.5 0.98095 -1.7988 0 0 0 0 0 0 0 0 0 0 0 7.26969 Q15828 CYTM_HUMAN Cystatin-M (Cystatin-6) (Cystatin-E) CST6 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; epidermis development [GO:0008544] cornified envelope [GO:0001533]; extracellular exosome [GO:0070062] cysteine-type endopeptidase inhibitor activity [GO:0004869] ARPQERMVGELR 1 8.1 0.92472 -0.44848 0 0 0 0 9.27775 0 0 0 0 0 0 0 Q15831 STK11_HUMAN Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) STK11 LKB1 PJS Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; DNA damage response [GO:0006974]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; establishment of cell polarity [GO:0030010]; G1 to G0 transition [GO:0070314]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vesicle transport along microtubule [GO:1901610]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of Wnt signaling pathway [GO:0030111]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to ionizing radiation [GO:0010212]; response to lipid [GO:0033993]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular protein-containing complex [GO:0140535]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HPPAEAPVPIPPSPDTKDR 1 4.4 0.88028 -0.15376 0 0 0 0 0 0 11.0699 0 0 0 0 0 Q15833 STXB2_HUMAN Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) STXBP2 UNC18B Homo sapiens (Human) intracellular protein transport [GO:0006886]; leukocyte mediated cytotoxicity [GO:0001909]; neutrophil degranulation [GO:0043312]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of mast cell degranulation [GO:0043304]; vesicle docking involved in exocytosis [GO:0006904] azurophil granule [GO:0042582]; cytolytic granule [GO:0044194]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820] syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348] IRVLLLYILLR;KLEDIALP;SQLLIMDR;YSTHLHLADDCMKHFK 4 7.3 0.91711 -0.41826 6.43032 12.7216 0 3.26281 0 0 0 0 0 0 5.32193 0 Q15834 CC85B_HUMAN Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A) CCDC85B DIPA Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599] adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634] delta-catenin binding [GO:0070097] QWQLFGTQASR 1 5.4 0.89843 -0.23363 0 10.8284 0 0 0 0 0 0 0 0 0 0 Q15835 GRK1_HUMAN Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) GRK1 RHOK Homo sapiens (Human) G protein-coupled opsin signaling pathway [GO:0016056]; protein autophosphorylation [GO:0046777]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of opsin-mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; visual perception [GO:0007601] cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254] YLAKLKLPPLSK 1 2.1 0.86954 -0.098936 0 0 0 0 0 0 4.31962 0 0 0 0 0 Q15836 VAMP3_HUMAN Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) VAMP3 SYB3 Homo sapiens (Human) "calcium-ion regulated exocytosis [GO:0017156]; cellular response to type II interferon [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075] RLQQTQNQVDEVVDIMRVNVDK;VLERDQK 2 29 0.96173 -1.0739 0 0 0 0 0 8.88423 0 0 0 0 0 0 Q15842 KCNJ8_HUMAN "ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)" KCNJ8 Homo sapiens (Human) "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; kidney development [GO:0001822]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]" glutamatergic synapse [GO:0098978]; inward rectifying potassium channel [GO:0008282]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; inward rectifier potassium channel activity [GO:0005242]; sulfonylurea receptor binding [GO:0017098]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] DRLPKAR 1 1.7 0.9797 -1.5384 0 14.4003 0 0 0 0 0 0 0 0 0 0 Q15843 NEDD8_HUMAN Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) NEDD8 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; modification-dependent protein catabolic process [GO:0019941]; protein localization [GO:0008104]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of postsynapse assembly [GO:0150052]; regulation of proteolysis [GO:0030162]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625] ILGGSVLHLVLALR;LIKVKTLTGK 2 29.6 0.76524 0.061822 0 0 3.19886 0 0 0 0 0 3.49326 3.9885 0 0 Q15853 USF2_HUMAN Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2) USF2 BHLHB12 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; glucose mediated signaling pathway [GO:0010255]; lactation [GO:0007595]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GGILSKACDYIR;TETNGGQVTYR 2 6.6 0.95072 -0.66676 10.5693 0 9.27738 0 0 0 0 0 0 0 0 0 Q15858 SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) SCN9A NENA Homo sapiens (Human) action potential propagation [GO:0098870]; behavioral response to pain [GO:0048266]; cardiac muscle cell action potential involved in contraction [GO:0086002]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; neuronal action potential [GO:0019228]; post-embryonic development [GO:0009791]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; axon terminus [GO:0043679]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] IGRILRLVK;RKQEDVSATVIQR;TISVIPGLKTIVGALIQSVK;TLRALRPLRALSR;VLRALKTISVIPGLK 5 3.1 0.97379 -1.3968 0 0 0 0 0 0 0 0 0 4.56615 0 0 Q15878 CAC1E_HUMAN "Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)" CACNA1E CACH6 CACNL1A6 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843] AVRVLRPLKLVSGIPSLQIVLK;ISIRHMVK;RSNSSWLEEFSMER;SAKVDGVSYFR;TEPYFIGIFCFEAGIKIVALGFIFHK;VIAFGFLNYFR;VISQSEPDLSCITANTDK;VLRPLKLVSGIPSLQIVLKSIMK;VLRPLKTIKR 9 5.4 0.97277 -2.9572 5.27236 0 0 10.0055 0 9.31445 12.8617 0 0 0 0 0 Q15884 EREP1_HUMAN Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) ENTREP1 C9orf61 FAM189A2 X123 Homo sapiens (Human) CXCL12-activated CXCR4 signaling pathway [GO:0038160]; negative adaptation of signaling pathway [GO:0022401]; receptor internalization [GO:0031623] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ubiquitin ligase activator activity [GO:1990757] CDLVDLGEGK;ENALKLFPVQPCSAVHLLLK 2 6.7 0.95157 -0.6908 0 0 0 0 0 0 0 0 0 7.94808 0 0 Q15904 VAS1_HUMAN V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3 Homo sapiens (Human) cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; endosome to plasma membrane protein transport [GO:0099638]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; osteoclast development [GO:0036035]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672] ATPase activator activity [GO:0001671]; small GTPase binding [GO:0031267]; transporter activator activity [GO:0141109] GPTISLTQIV 1 2.1 0.91579 -0.37316 0 0 0 0 0 0 0 0 0 11.9074 0 0 Q15906 VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) VPS72 TCFL1 YL1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713] MSLAGGR;SLETYER 2 3.8 0.91542 -0.34038 0 0 0 0 0 7.99656 0 0 0 0 0 7.90983 Q15911 ZFHX3_HUMAN Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) ZFHX3 ATBF1 C16orf47 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of locomotor rhythm [GO:1904059]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" CNQCSLAFKTIEK;EKEKESQR;LAEAPSAQPNQTQEK;LQLHSQYHVIR;MLDHIAHEVGLK;NSCKTLKCPK;QEVGDGDCFSEK;RALQESATGQPEPTSSPDNKPFK;TLLSPSSIK;TRITDDQLR;VIKHWFR;YIRTSNLNYQCKK;YNTQLKANFQLHCKTDK;YSARLSVR 14 4.5 0.97671 -5.4776 11.5771 0 0 0 4.543 0 3.74588 0 11.4018 0 7.09381 0 Q15916 ZBTB6_HUMAN Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain) ZBTB6 ZID ZNF482 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CHCCDMDFK;LSRPDLKRQSLL 2 5 0.91757 -0.4208 0 9.26026 0 0 0 0 5.26641 0 0 0 0 0 Q15928 ZN141_HUMAN Zinc finger protein 141 ZNF141 D4S90 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; limb morphogenesis [GO:0035108]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KGCKSLNECK;RIHTGEKPYTCEECGK;VHTGERPYKCDECGK 3 8.6 0.97476 -3.0924 0 0 0 8.69335 0 0 0 12.6971 0 0 0 0 Q15935 ZNF77_HUMAN Zinc finger protein 77 (ZNFpT1) ZNF77 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ECGQACSCLSCQSPPMK;TFMYYSYLTRHVR 2 5.5 0.91708 -0.42796 0 0 0 0 0 0 6.29096 0 0 4.80307 0 0 Q15937 ZNF79_HUMAN Zinc finger protein 79 (ZNFpT7) ZNF79 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EGIPGKSR;THTGEKPYRCSECEKAFSDCSALVQHQR 2 7.2 0.96677 -1.2804 0 0 7.07628 0 0 0 8.72537 0 9.04734 0 0 0 Q15940 ZNF67_HUMAN Putative zinc finger protein 726P1 ZNF726P1 ZNF67 ZNF67P Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SIYTREKSYK 1 5.2 0.97518 -1.4582 11.5577 0 0 0 0 0 0 0 0 0 0 0 Q15942 ZYX_HUMAN Zyxin (Zyxin-2) ZYX Homo sapiens (Human) cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] metal ion binding [GO:0046872]; RNA binding [GO:0003723] NDPFKAR;VNPFRPGDSEPPPAPGAQR 2 4.5 0.073171 0.41775 0 0 0 0 0 0 9.19547 0 8.84166 7.31669 0 0 Q15973 ZN124_HUMAN Zinc finger protein 124 (Zinc finger protein HZF-16) ZNF124 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AHAGEEPYPCKQCGK;IHTGEKRYECK 2 7.4 0.97912 -1.8832 0 0 0 7.43663 10.3454 0 0 0 0 0 0 0 Q16134 ETFD_HUMAN "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)" ETFDH Homo sapiens (Human) electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038]; ubiquinone binding [GO:0048039]" NLSIYDGPEQR;QLYKKFDLR 2 3.2 0.94456 -0.63022 0 0 0 0 0 0 10.4452 0 0 10.7431 0 0 Q16143 SYUB_HUMAN Beta-synuclein SNCB Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488] axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; neuronal cell body [GO:0043025] calcium ion binding [GO:0005509]; cuprous ion binding [GO:1903136]; phospholipase inhibitor activity [GO:0004859]; transition metal ion binding [GO:0046914] EGVVAAAEKTKQGVTEAAEK 1 14.9 0.4632 0.19077 0 0 0 0 4.31426 0 0 0 0 0 0 0 Q16181 SEPT7_HUMAN Septin-7 (CDC10 protein homolog) SEPTIN7 CDC10 SEPT7 Homo sapiens (Human) cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; protein localization [GO:0008104]; regulation of embryonic cell shape [GO:0016476]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] ILEQQNSSR;NMLIRTHMQDLK;SPLAQMEEERR;TLEKNKK;VNIIPLIAK 5 11 0.020913 0.65243 9.50637 10.5402 10.599 0 8.15871 0 9.22101 0 9.73254 10.6071 10.7814 11.2169 Q16186 ADRM1_HUMAN Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) ADRM1 GP110 Homo sapiens (Human) proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; transcription elongation by RNA polymerase II [GO:0006368] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]" endopeptidase activator activity [GO:0061133]; molecular function inhibitor activity [GO:0140678]; protease binding [GO:0002020]; proteasome binding [GO:0070628] TTSGALFPSLVPGSR 1 3.7 0 3.9202 11.6154 10.9664 11.1312 10.1441 9.50148 9.16154 0 0 0 8.8782 9.30469 10.4585 Q16204 CCDC6_HUMAN Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) CCDC6 D10S170 TST1 Homo sapiens (Human) cytoskeleton [GO:0005856]; cytosol [GO:0005829] identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200] CKALQEENR;KLQREMER 2 3.6 0.98025 -1.8657 0 0 0 0 0 0 0 0 0 0 8.42417 0 Q16206 ENOX2_HUMAN Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX2 COVA1 Homo sapiens (Human) electron transport chain [GO:0022900]; ultradian rhythm [GO:0007624] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723] ALYLSGYRIR;DTGRLHVDFAQAR;LGSSTDK;LKDDSKFSEAVQTLLTWIER;LLQQALQGMQQHLLKVQEEYK;QEQGKVHR 6 13 0.97439 -3.7807 8.33731 0 0 9.8404 9.57928 0 0 0 0 0 10.2489 7.03617 Q16222 UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) UAP1 SPAG2 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977] LGVAYPK;LQQVAEK;TMESTKEFFTKHK 3 5.2 0.93733 -0.56699 0 0 0 0 3.13126 0 0 0 0 9.83417 0 0 Q16254 E2F4_HUMAN Transcription factor E2F4 (E2F-4) E2F4 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; blood circulation [GO:0008015]; cell volume homeostasis [GO:0006884]; centriole assembly [GO:0098534]; epithelial cell development [GO:0002064]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KYQIHLK 1 1.7 0.93349 -0.50841 0 0 0 0 0 0 0 0 0 12.1182 0 0 Q16270 IBP7_HUMAN Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF) IGFBP7 MAC25 PSF Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular response to hormone stimulus [GO:0032870]; embryo implantation [GO:0007566]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; regulation of steroid biosynthetic process [GO:0050810]; response to cortisol [GO:0051414]; response to retinoic acid [GO:0032526] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] insulin-like growth factor binding [GO:0005520]; receptor ligand activity [GO:0048018] DACGCCPMCAR 1 3.9 0.80747 0.0072549 0 0 0 0 0 0 4.85085 0 4.76086 0 0 0 Q16280 CNGA2_HUMAN Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1) CNGA2 CNCA CNCA1 CNCG2 Homo sapiens (Human) calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814] ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] FNRLLHFARMFEFFDR;ITVLETK;LADVDAPQQGR;LLAEYTGAQQK;LRDNYIHTLQFK;RIVRLVGIIR;VIRWFDYLWTNK 7 11.9 0.97597 -2.3001 0 3.03418 0 9.97083 8.84229 0 9.63644 0 0 7.88478 9.96404 0 Q16281 CNGA3_HUMAN Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3) CNGA3 CNCG3 Homo sapiens (Human) inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601] axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] EVLKSLPDK;LRPTVFSPGDYICK;LSRLIFLLR;LSRLIFLLRR 4 4.8 0.98011 -1.6508 0 13.7707 3.79847 6.59412 0 6.47037 7.69704 0 0 0 0 0 Q16348 S15A2_HUMAN "Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)" SLC15A2 PEPT2 Homo sapiens (Human) "antibacterial innate immune response [GO:0140367]; dipeptide import across plasma membrane [GO:0140206]; dipeptide transport [GO:0042938]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; protein transport [GO:0015031]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; renal absorption [GO:0070293]; transport across blood-brain barrier [GO:0150104]; tripeptide import across plasma membrane [GO:0140207]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]" apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937] HIPHIQGNMIK;LVSKCGINFSSLRK;YPKQLIMDVK 3 4.8 0.82957 -0.021893 6.52549 0 0 10.1184 0 0 0 0 0 11.1961 0 11.704 Q16352 AINX_HUMAN Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) INA NEF5 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament organization [GO:0045109]; neurofilament cytoskeleton organization [GO:0060052]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685] structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184] EYQDLLNVK;HLREYQDLLNVK;TIEIEGLR;VFGDGSR 4 5.4 0.95519 -0.80487 0 0 0 10.1585 0 10.6344 7.95064 0 0 0 0 10.8159 Q16363 LAMA4_HUMAN Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) LAMA4 Homo sapiens (Human) cell adhesion [GO:0007155]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102] IEQTQASEK 1 0.5 0.93194 -0.49101 0 0 0 0 0 0 0 9.22629 0 0 0 0 Q16384 SSX1_HUMAN "Protein SSX1 (Cancer/testis antigen 5.1) (CT5.1) (Synovial sarcoma, X breakpoint 1)" SSX1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] transcription corepressor activity [GO:0003714] ASEKRSK;INKRSGPK;MKYSEKISYVYMK;VTLPPFMCNK 4 20.2 0.96629 -1.1288 12.278 0 0 0 9.61717 10.9266 0 8.8715 0 0 0 0 Q16385 SSX2_HUMAN "Protein SSX2 (Cancer/testis antigen 5.2) (CT5.2) (Synovial sarcoma, X breakpoint 2) (Tumor antigen HOM-MEL-40)" SSX2 SSX2A; SSX2B Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] IFYVYMK 1 3.1 0.93721 -0.57629 0 11.6122 0 0 0 0 0 0 0 0 0 0 Q16394 EXT1_HUMAN Exostosin-1 (EC 2.4.1.225) (Exostosin glycosyltransferase 1) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 1) (N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) EXT1 Homo sapiens (Human) "antigen processing and presentation [GO:0019882]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; bone resorption [GO:0045453]; canonical Wnt signaling pathway [GO:0060070]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell adhesion mediated by integrin [GO:0033627]; cell fate commitment [GO:0045165]; cellular response to virus [GO:0098586]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate metabolic process [GO:0030204]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dendrite self-avoidance [GO:0070593]; dendritic cell migration [GO:0036336]; developmental growth involved in morphogenesis [GO:0060560]; embryonic skeletal joint development [GO:0072498]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fear response [GO:0042596]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fluid transport [GO:0042044]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glomerular basement membrane development [GO:0032836]; glycosaminoglycan biosynthetic process [GO:0006024]; hair follicle morphogenesis [GO:0031069]; heart contraction [GO:0060047]; heart field specification [GO:0003128]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; hypersensitivity [GO:0002524]; leukocyte tethering or rolling [GO:0050901]; limb joint morphogenesis [GO:0036022]; lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339]; lymphocyte migration into lymphoid organs [GO:0097021]; mesenchymal cell differentiation involved in bone development [GO:1901706]; mesoderm development [GO:0007498]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neural crest cell differentiation [GO:0014033]; olfactory bulb development [GO:0021772]; optic nerve development [GO:0021554]; ossification [GO:0001503]; ossification involved in bone maturation [GO:0043931]; perichondral bone morphogenesis [GO:0061974]; podocyte differentiation [GO:0072112]; polysaccharide biosynthetic process [GO:0000271]; protein catabolic process [GO:0030163]; protein glycosylation [GO:0006486]; protein-containing complex assembly [GO:0065003]; regulation of blood pressure [GO:0008217]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to heparin [GO:0071503]; response to leukemia inhibitory factor [GO:1990823]; response to light intensity [GO:0009642]; sebaceous gland development [GO:0048733]; smoothened signaling pathway involved in lung development [GO:0060506]; social behavior [GO:0035176]; sodium ion homeostasis [GO:0055078]; stem cell division [GO:0017145]; stomach development [GO:0062094]; sulfation [GO:0051923]; sweat gland development [GO:0060792]; synaptic transmission, glutamatergic [GO:0035249]; tight junction organization [GO:0120193]; vacuole organization [GO:0007033]; vasodilation [GO:0042311]; vocalization behavior [GO:0071625]; wound healing [GO:0042060]" catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; synapse [GO:0045202] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] KYRDIER;LDPVLFK;LLVAAAK;SHFWDNSKERWGYTSK 4 5 0.97547 -1.4335 8.03326 9.60201 0 0 0 6.45161 0 0 0 0 0 0 Q16401 PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) PSMD5 KIAA0072 Homo sapiens (Human) proteasome regulatory particle assembly [GO:0070682] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502] AAQALALLR;QIVYCIGGENLSVAK;TIAEIFGNPNYLRLR 3 7.7 0 3.474 0 11.2693 0 0 0 0 0 0 0 7.39592 0 0 Q16445 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) (GABAAR subunit alpha-6) GABRA6 Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" cerebellar Golgi cell to granule cell synapse [GO:0099192]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ATEPLEAEIVLHPDSKYHLK;ITSLSLPIVSSSEANK;SIAHNMTTPNKLFR 3 11 0.97514 -1.4546 0 0 0 0 0 11.6866 0 0 0 0 7.15947 0 Q16478 GRIK5_HUMAN "Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)" GRIK5 GRIK2 Homo sapiens (Human) "excitatory postsynaptic potential [GO:0060079]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic transmission, glutamatergic [GO:0035249]" cell projection [GO:0042995]; endoplasmic reticulum [GO:0005783]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DSQYETTDTMCQILPK;SFNYPSASLICAKAECLLRLEELVR 2 4.2 0.43173 0.19502 0 5.87953 0 0 0 0 0 7.56255 0 0 0 0 Q16512 PKN1_HUMAN Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKN1 PAK1 PKN PRK1 PRKCL1 Homo sapiens (Human) B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; epithelial cell migration [GO:0010631]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of cell motility [GO:2000145]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of transcription by RNA polymerase II [GO:0006357]; renal system process [GO:0003014]; signal transduction [GO:0007165]; spleen development [GO:0048536] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; chromatin binding [GO:0003682]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3T11 kinase activity [GO:0035402]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]" AIFYSACVVLGLQFLHEHKIVYR;ATTDLGRSLGPVELLLR;LGSSERDAEDVKK 3 5.6 0.97989 -1.8212 12.8644 0 12.5095 8.76646 0 8.54724 0 11.1357 11.202 0 0 0 Q16513 PKN2_HUMAN Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKN2 PRK2 PRKCL2 Homo sapiens (Human) apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165] apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]" ASSLGEIDESSELR;LEELHHK;LGASEKDAEDVK;LIDWSALMDKK;RLGASEK 5 4.6 0.95631 -0.99362 0 0 0 0 7.9909 0 10.4171 0 0 9.37495 0 0 Q16513 PKN2_HUMAN Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKN2 PRK2 PRKCL2 Homo sapiens (Human) apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165] apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]" ASSLGEIDESSELR;IQMYSNGSSK;LGASEKDAEDVK;LIDWSALMDKK;RLGASEK 5 5.8 0.93535 -0.52933 0 0 0 0 0 0 0 0 0 0 10.4189 0 Q16515 ASIC2_HUMAN "Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)" ASIC2 ACCN ACCN1 BNAC1 MDEG Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of apoptotic process [GO:0043066]; peripheral nervous system development [GO:0007422]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of postsynapse assembly [GO:0150052]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; synapse assembly [GO:0007416] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839]; voltage-gated sodium channel activity [GO:0005248] DMMLYCKFK;YLEKKFNK 2 3.3 0.98019 -1.5634 0 0 0 0 0 0 11.3887 0 0 0 10.0642 0 Q16515 ASIC2_HUMAN "Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)" ASIC2 ACCN ACCN1 BNAC1 MDEG Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of apoptotic process [GO:0043066]; peripheral nervous system development [GO:0007422]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of postsynapse assembly [GO:0150052]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; synapse assembly [GO:0007416] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839]; voltage-gated sodium channel activity [GO:0005248] ALQGPGVAR;LLYWLSFPSHTR;YLEKKFNK 3 5.2 0.97302 -2.505 0 0 0 0 0 0 0 0 10.8108 0 0 0 Q16517 NNAT_HUMAN Neuronatin NNAT Homo sapiens (Human) brain development [GO:0007420]; positive regulation of insulin secretion [GO:0032024]; protein lipoylation [GO:0009249] cytoplasm [GO:0005737] VLLQVFRYSLQK;YSLQKLAYTVSR 2 35.2 0.91628 -0.34702 0 0 0 0 0 3.05078 0 0 0 0 10.2055 0 Q16526 CRY1_HUMAN Cryptochrome-1 CRY1 PHLL1 Homo sapiens (Human) blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein ubiquitination [GO:0031398]; regulation of circadian rhythm [GO:0042752]; regulation of DNA damage checkpoint [GO:2000001]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; signal transduction in response to DNA damage [GO:0042770] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] blue light photoreceptor activity [GO:0009882]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; FAD binding [GO:0071949]; histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901] LSIEYDSEPFGK;QIYQQLSRYR 2 3.8 0.91614 -0.43339 0 0 0 0 0 0 0 11.4945 0 0 0 9.82966 Q16531 DDB1_HUMAN DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) DDB1 XAP1 Homo sapiens (Human) apoptotic process [GO:0006915]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; ectopic germ cell programmed cell death [GO:0035234]; epigenetic programming in the zygotic pronuclei [GO:0044725]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; nucleotide-excision repair [GO:0006289]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral genome replication [GO:0045070]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle phase transition [GO:1901990]; rhythmic process [GO:0048511]; spindle assembly involved in female meiosis [GO:0007056]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914]; viral release from host cell [GO:0019076]; Wnt signaling pathway [GO:0016055] "chromosome, telomeric region [GO:0000781]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]" cullin family protein binding [GO:0097602]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; WD40-repeat domain binding [GO:0071987] LGDSQLVK;LPSFELLHK;LVSQEPK;TVPLYESPR;VIKSVGK;VVEELTR 6 4.1 0.97986 -1.8318 0 0 0 7.67976 0 0 0 0 0 11.1844 11.7418 0 Q16533 SNPC1_HUMAN snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) SNAPC1 SNAP43 Homo sapiens (Human) snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185] RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; sequence-specific DNA binding [GO:0043565] FGTIFCGR;FGTIFCGRMRNLEK 2 3.8 0.95286 -0.76703 0 0 0 0 0 0 11.5485 0 0 0 0 0 Q16534 HLF_HUMAN Hepatic leukemia factor HLF Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" ENQIAIRASFLEK 1 6.2 0.94434 -0.63545 0 0 0 0 0 0 0 0 0 0 0 9.9491 Q16537 2A5E_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) PPP2R5E Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] AFIRKQINNIFLR;LEDLELK 2 4.3 0.95186 -0.68368 0 0 0 0 0 0 0 0 0 0 0 9.54607 Q16538 GP162_HUMAN Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein) GPR162 GRCA Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ARGGAGAEEASLRSNALSWLACGLLALLANAWIILSISAK;LSLGSPESR;RLSLGSPESR;VGGGGGTK 4 9.9 0.95822 -1.0116 9.04316 0 7.51594 0 0 0 0 0 0 0 0 10.6878 Q16539 MK14_HUMAN Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; D-glucose import [GO:0046323]; DNA damage checkpoint signaling [GO:0000077]; fatty acid oxidation [GO:0019395]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; placenta development [GO:0001890]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cyclase activity [GO:0031281]; positive regulation of D-glucose import [GO:0046326]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of ossification [GO:0030278]; regulation of synaptic membrane adhesion [GO:0099179]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; transcription by RNA polymerase II [GO:0006366]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; spindle pole [GO:0000922] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] LSRPFQSIIHAK;LTGTPPAYLINR 2 6.7 0.91562 -0.39076 0 0 0 0 0 0 0 0 0 7.09919 0 10.0323 Q16539 MK14_HUMAN Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; D-glucose import [GO:0046323]; DNA damage checkpoint signaling [GO:0000077]; fatty acid oxidation [GO:0019395]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; placenta development [GO:0001890]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cyclase activity [GO:0031281]; positive regulation of D-glucose import [GO:0046326]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of ossification [GO:0030278]; regulation of synaptic membrane adhesion [GO:0099179]; regulation of transcription by RNA polymerase II [GO:0006357]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; transcription by RNA polymerase II [GO:0006366]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; spindle pole [GO:0000922] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] CLYWTQIR;LSRPFQSIIHAK 2 6.5 0.87893 -0.14057 0 0 0 0 0 0 0 0 0 0 0 4.99702 Q16543 CDC37_HUMAN "Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]" CDC37 CDC37A Homo sapiens (Human) positive regulation of type 2 mitophagy [GO:1905091]; post-transcriptional regulation of gene expression [GO:0010608]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; regulation of type II interferon-mediated signaling pathway [GO:0060334] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; HSP90-CDC37 chaperone complex [GO:1990565]; protein folding chaperone complex [GO:0101031] heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein-folding chaperone binding [GO:0051087]; scaffold protein binding [GO:0097110]; unfolded protein binding [GO:0051082] EGEEAGPGDPLLEAVPK;ELEVAEGGK;LGPGGLDPVEVYESLPEELQK 3 12.4 0 3.8834 0 0 0 0 0 0 9.99972 0 0 0 13.6171 11.0151 Q16549 PCSK7_HUMAN Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7) PCSK7 LPC PC7 PC8 SPC7 Homo sapiens (Human) peptide hormone processing [GO:0016486]; protein processing [GO:0016485] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] ENKAIPQSPRSLEVLWNVSR;LLESAMSGK 2 3.7 0.94106 -0.59987 0 0 0 0 0 9.44659 0 0 9.37352 0 0 0 Q16552 IL17_HUMAN Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8) IL17A CTLA8 IL17 Homo sapiens (Human) adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; cell death [GO:0008219]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; fibroblast activation [GO:0072537]; gene expression [GO:0010467]; granulocyte migration [GO:0097530]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intestinal epithelial structure maintenance [GO:0060729]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of inflammatory response to wounding [GO:0106015]; Notch signaling pathway [GO:0007219]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-16 production [GO:0032739]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; response to wounding [GO:0009611] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] NPGCPNSEDK;TSLVSLLLLLSLEAIVKAGITIPR 2 21.9 0.90882 -0.27807 0 0 0 0 0 0 0 0 0 0 9.07385 0 Q16555 DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) DPYSL2 CRMP2 ULIP2 Homo sapiens (Human) cell differentiation [GO:0030154]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "dihydropyrimidinase activity [GO:0004157]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]" DHGVNSFLVYMAFKDR;GSPLVVISQGK;IVAPPGGR;QIGENLIVPGGVK;QQAPPVR;SSAEVIAQAR;TIEAHSR;TVTPASSAK 8 14.2 0.97396 -1.3982 0 0 8.30241 0 0 0 9.61791 8.42278 0 10.782 12.2833 0 Q16558 KCMB1_HUMAN "Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta)" KCNMB1 Homo sapiens (Human) cellular response to bile acid [GO:1903413]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813]; vasodilation [GO:0042311] plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459] LVMAQKR;LVMAQKRGETR 2 8.5 0.95479 -0.88363 0 0 0 0 0 0 0 0 0 9.91997 0 9.93512 Q16559 TAL2_HUMAN T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19) TAL2 BHLHA19 Homo sapiens (Human) midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; thalamus development [GO:0021794] chromatin [GO:0000785] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" WRQQNVNSAFAK 1 11.1 0.88059 -0.15635 0 0 10.6027 0 0 0 0 0 0 0 0 0 Q16566 KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) adaptive immune response [GO:0002250]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] CKQKGTQKPYALK;LSHPNIIK;LTTFQALQHPWVTGK 3 7.6 0.95308 -0.72802 10.4766 0 0 0 0 0 0 0 11.2543 0 0 0 Q16576 RBBP7_HUMAN Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) RBBP7 RBAP46 Homo sapiens (Human) brain development [GO:0007420]; cellular heat acclimation [GO:0070370]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; response to steroid hormone [GO:0048545] "ATPase complex [GO:1904949]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; Sin3-type complex [GO:0070822]" histone binding [GO:0042393]; RNA binding [GO:0003723] EMFEDTVEER;IECEIKINHEGEVNRAR;INHEGEVNR;TPSSDVLVFDYTK;TVALWDLR;YMPQNPHIIATK 6 14.1 0 3.6297 0 0 0 0 0 0 11.2424 0 10.897 10.3583 9.01544 0 Q16584 M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) MAP3K11 MLK3 PTK1 SPRK Homo sapiens (Human) cell cycle G1/S phase transition [GO:0044843]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; microtubule-based process [GO:0007017]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron apoptotic process [GO:0043525]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] DLQPPGGPGR;QDPDEDISVTAESVRQEAR 2 3.4 0.89669 -0.24776 0 0 10.6372 0 0 0 0 0 0 0 0 10.8134 Q16585 SGCB_HUMAN Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b) SGCB Homo sapiens (Human) cardiac muscle cell development [GO:0055013]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]; vascular associated smooth muscle cell development [GO:0097084] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] TIEFHMGGNMELK;VDGRAIVR 2 6.6 0.84126 -0.050069 0 0 6.25826 0 0 11.0984 0 0 0 0 0 0 Q16587 ZNF74_HUMAN Zinc finger protein 74 (Zinc finger protein 520) (hZNF7) ZNF74 ZNF520 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAGAGEGEFVCGECGK 1 2.5 0.78332 0.026372 0 0 0 0 0 0 0 0 0 0 8.91058 0 Q16594 TAF9_HUMAN Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) TAF9 TAF2G TAFII31 Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein stabilization [GO:0050821]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-1 [GO:0070555]; response to L-glutamate [GO:1902065]; RNA polymerase II preinitiation complex assembly [GO:0051123] MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] KREDDDDDDDDDDDYDNL;VINQMLEFAFR 2 11 0.43147 0.19539 6.23414 0 5.03329 0 3.8523 0 0 0 0 0 4.3886 0 Q16595 FRDA_HUMAN "Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin]" FXN FRDA X25 Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; adult walking behavior [GO:0007628]; cellular response to hydrogen peroxide [GO:0070301]; embryo development ending in birth or egg hatching [GO:0009792]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron ion transport [GO:0006826]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial respiratory chain complex III assembly [GO:0034551]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; organ growth [GO:0035265]; oxidative phosphorylation [GO:0006119]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]; proprioception [GO:0019230]; protein autoprocessing [GO:0016540]; regulation of ferrochelatase activity [GO:0010722]; response to iron ion [GO:0010039] cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron chaperone activity [GO:0034986]" AVAGLLASPSPAQAQTLTR 1 9 0.64132 0.17203 0 0 0 0 0 0 0 0 0 0 7.75949 0 Q16602 CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (CRLR) CALCRL CGRPR Homo sapiens (Human) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to sucrose stimulus [GO:0071329]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; heart development [GO:0007507]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; vascular associated smooth muscle cell proliferation [GO:1990874]" adrenomedullin receptor complex [GO:1903143]; CGRP receptor complex [GO:1990406]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]; G protein-coupled receptor activity [GO:0004930] VLITKLK 1 1.5 0.98043 -1.6404 0 0 9.40629 0 0 0 0 0 0 0 0 0 Q16610 ECM1_HUMAN Extracellular matrix protein 1 (Secretory component p85) ECM1 Homo sapiens (Human) angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020] DILTIDIGR;ELLALIQLEREFQR 2 4.3 0.92201 -0.44332 0 0 0 3.90149 0 0 0 0 0 0 0 0 Q16610 ECM1_HUMAN Extracellular matrix protein 1 (Secretory component p85) ECM1 Homo sapiens (Human) angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020] DILTIDIGR;LVWEDTLDKYCDR 2 5.3 0.91415 -0.32951 0 7.42534 0 0 0 0 0 11.0802 0 0 0 0 Q16610 ECM1_HUMAN Extracellular matrix protein 1 (Secretory component p85) ECM1 Homo sapiens (Human) angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020] LVVRLGS 1 4.1 0.98063 -1.609 0 0 0 0 0 0 11.5013 0 0 0 0 0 Q16612 NREP_HUMAN Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311) NREP C5orf13 P311 Homo sapiens (Human) axon regeneration [GO:0031103]; regulation of neuron differentiation [GO:0045664]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] cytoplasm [GO:0005737] DMEGRLPK;NDETNAASLTPLGSSELR 2 38.2 0.90932 -0.31087 0 0 3.8799 0 0 0 0 8.94863 0 0 0 0 Q16620 NTRK2_HUMAN BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) NTRK2 TRKB Homo sapiens (Human) "brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amino acid stimulus [GO:0071230]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; circadian rhythm [GO:0007623]; feeding behavior [GO:0007631]; glutamate secretion [GO:0014047]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; mechanoreceptor differentiation [GO:0042490]; myelination in peripheral nervous system [GO:0022011]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system neuron development [GO:0048935]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; retinal rod cell development [GO:0046548]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trans-synaptic signaling by neuropeptide, modulating synaptic transmission [GO:0099551]; vasculogenesis [GO:0001570]" axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]; terminal bouton [GO:0043195] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor binding [GO:0048403]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; neurotrophin binding [GO:0043121]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] RLEIINEDDVEAYVGLR;VGGHTMLPIRWMPPESIMYR 2 4.5 0.57918 0.18007 0 0 0 0 0 0 0 0 9.10071 0 0 0 Q16621 NFE2_HUMAN "Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2)" NFE2 Homo sapiens (Human) hemostasis [GO:0007599]; integrated stress response signaling [GO:0140467]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; WW domain binding [GO:0050699]" TLEVMRQQLTELYR;VAAQNCRKR 2 6.2 0.92227 -0.44332 0 0 0 0 0 0 9.64703 0 0 0 0 0 Q16625 OCLN_HUMAN Occludin OCLN Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of D-glucose import [GO:0046326]; positive regulation of gene expression [GO:0010628]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of wound healing [GO:0090303]; protein localization to cell leading edge [GO:1902463]; protein-containing complex assembly [GO:0065003]; regulation of D-glucose transmembrane transport [GO:0010827] apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160] protein domain specific binding [GO:0019904] AYSSNGK;KNHCKQLK;SLQSELDEINKELSR 3 15 0.98213 -1.5858 0 0 9.04237 6.67044 0 0 0 9.47575 11.285 0 0 0 Q16627 CCL14_HUMAN C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)] CCL14 NCC2 SCYA14 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284] extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] GHSVCTNPSDKWVQDYIKDMK 1 22.6 0.95788 -1.0186 0 0 0 0 0 0 0 0 13.7386 0 0 0 Q16629 SRSF7_HUMAN "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AFSYYGPLR;NPPGFAFVEFEDPR;SISRPRSSR;VYVGNLGTGAGK;YSRSRSR 5 21.4 0.97682 -2.2096 0 4.3048 0 0 0 0 11.601 0 0 11.544 11.3145 11.1892 Q16630 CPSF6_HUMAN Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) CPSF6 CFIM68 Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of RNA export from nucleus [GO:0046833]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904] exon-exon junction complex binding [GO:1990448]; mRNA binding [GO:0003729]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] DYMDTLPPTVGDDVGK 1 2.9 0.77484 0.046207 0 8.71685 0 0 0 0 0 0 0 0 0 0 Q16633 OBF1_HUMAN POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1) POU2AF1 BOB1 OBF1 Homo sapiens (Human) cellular response to virus [GO:0098586]; germinal center B cell differentiation [GO:0002314]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944] RNA polymerase II transcription regulator complex [GO:0090575] DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] VKEPVKELLR 1 3.9 0.76717 0.059248 0 0 0 0 0 0 0 9.8396 0 0 0 0 Q16635 TAZ_HUMAN Tafazzin (Taz) (EC 2.3.1.-) (Protein G4.5) TAFAZZIN EFE2 G4.5 TAZ Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cardiac muscle tissue development [GO:0048738]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; cardiolipin metabolic process [GO:0032048]; cristae formation [GO:0042407]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; muscle contraction [GO:0006936]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cardiolipin metabolic process [GO:1900210]; skeletal muscle tissue development [GO:0007519]; spermatocyte division [GO:0048137] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; O-acyltransferase activity [GO:0008374] YMNHLTVHNREVLYELIEK 1 7.3 0.82365 -0.018997 0 0 0 0 0 8.55428 0 0 0 0 0 0 Q16637 SMN_HUMAN Survival motor neuron protein (Component of gems 1) (Gemin-1) SMN1 SMN SMNT; SMN2 SMNC Homo sapiens (Human) DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018] identical protein binding [GO:0042802]; RNA binding [GO:0003723] AYDKAVASFK;CSAIWSEDGCIYPATIASIDFK;QNQKEGRCSHSLN 3 15.3 0.90118 -0.2601 6.13367 0 0 0 9.51132 0 7.19859 0 0 0 7.82082 0 Q16643 DREB_HUMAN Drebrin (Developmentally-regulated brain protein) DBN1 D0S117E Homo sapiens (Human) actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cytoplasmic sequestering of protein [GO:0051220]; generation of neurons [GO:0048699]; in utero embryonic development [GO:0001701]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic plasticity [GO:0031915]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168] actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; gap junction [GO:0005921]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522] EESAADWALYTYEDGSDDLK 1 3.1 0.78331 0.025586 6.18717 0 0 0 0 0 0 0 0 0 0 0 Q16644 MAPK3_HUMAN MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) MAPKAPK3 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; macropinocytosis [GO:0044351]; peptidyl-serine phosphorylation [GO:0018105]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DAVLKLTDFGFAK 1 3.4 0.9753 -1.4385 0 0 0 0 0 0 0 0 0 0 0 11.0765 Q16647 PTGIS_HUMAN Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) PTGIS CYP8 CYP8A1 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of angiogenesis [GO:0045766]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostaglandin biosynthetic process [GO:0001516] caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; nucleus [GO:0005634] "heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]" AWAALLGLLAALLLLLLLSR 1 4 0.64119 0.17351 0 0 0 0 0 3.49761 0 0 0 0 0 0 Q16649 NFIL3_HUMAN Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) NFIL3 E4BP4 IL3BP1 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; immune response [GO:0006955]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" TQNSFKTGVVEMK 1 2.8 0.9218 -0.44693 0 0 0 0 0 0 0 0 0 0 0 10.9811 Q16653 MOG_HUMAN Myelin-oligodendrocyte glycoprotein MOG Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] LAGQFLEELRKFSSLCYK;NGKDQDGDQAPEYR 2 10.8 0.53749 0.18583 0 0 0 0 0 10.7964 0 0 0 0 0 0 Q16653 MOG_HUMAN Myelin-oligodendrocyte glycoprotein MOG Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] AEIENLHRTFGQFLEELRNPF;NGKDQDGDQAPEYR;TFGQFLEELRNPF 3 16.8 0.91745 -0.36008 6.87603 0 0 8.51881 0 0 0 0 0 0 0 0 Q16656 NRF1_HUMAN Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) NRF1 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MTQAQLRAFIPEMLKYSTGR;RPHVFESNPSIRKR 2 6.8 0.96357 -1.093 0 0 0 10.1815 0 0 0 0 0 0 0 9.9073 Q16658 FSCN1_HUMAN Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) FSCN1 FAN1 HSN SNL Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell-cell junction assembly [GO:0007043]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of cell polarity [GO:0007163]; microspike assembly [GO:0030035]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of podosome assembly [GO:0071803]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microvillus assembly [GO:0032534] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microspike [GO:0044393]; microvillus [GO:0005902]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] TANGTAEAVQIQFGLINCGNK;VTGTLDANR;YLAPSGPSGTLK 3 8.5 0.91831 -0.40377 0 13.4909 0 0 11.1179 0 0 0 0 10.1957 0 0 Q16659 MK06_HUMAN Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) MAPK6 ERK3 PRKM6 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] IGDFGLARIMDPHYSHK;MAEKFESLMNIHGFDLGSR;SVSQEKQEK 3 6.2 0.96596 -1.1304 0 0 0 0 0 5.67973 0 0 9.41678 9.90785 10.9434 0 Q16665 HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) HIF1A BHLHE78 MOP1 PASD8 Homo sapiens (Human) angiogenesis [GO:0001525]; axonal transport of mitochondrion [GO:0019896]; B-1 B cell homeostasis [GO:0001922]; bone mineralization [GO:0030282]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen metabolic process [GO:0032963]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; elastin metabolic process [GO:0051541]; embryonic hemopoiesis [GO:0035162]; embryonic placenta development [GO:0001892]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial to mesenchymal transition [GO:0001837]; glandular epithelial cell maturation [GO:0002071]; heart looping [GO:0001947]; hemoglobin biosynthetic process [GO:0042541]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; intestinal epithelial cell maturation [GO:0060574]; intracellular glucose homeostasis [GO:0001678]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; iris morphogenesis [GO:0061072]; lactate metabolic process [GO:0006089]; lactation [GO:0007595]; mesenchymal cell apoptotic process [GO:0097152]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TOR signaling [GO:0032007]; neural crest cell migration [GO:0001755]; neural fold elevation formation [GO:0021502]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; outflow tract morphogenesis [GO:0003151]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitophagy [GO:1901526]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of aerobic respiration [GO:1903715]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of glycolytic process [GO:0006110]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to muscle activity [GO:0014850]; response to reactive oxygen species [GO:0000302]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; vascular endothelial growth factor production [GO:0010573]; visual learning [GO:0008542] axon cytoplasm [GO:1904115]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; motile cilium [GO:0031514]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]" LELVEKLFAEDTEAK;LFAEDTEAK;SPNVLSVALSQR 3 3.3 0.96564 -1.1271 0 0 0 0 4.05624 0 0 0 0 0 0 0 Q16666 IF16_HUMAN Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) IFI16 IFNGIP1 Homo sapiens (Human) "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; cellular response to glucose starvation [GO:0042149]; cellular response to interferon-beta [GO:0035458]; cellular response to ionizing radiation [GO:0071479]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription factor binding [GO:0008134] RNVLQKRPVIVK;TTIYEIQDDRGK;TVNQKTTIYEIQDDR;VLNTSLKEK 4 4.8 0.96535 -1.2432 0 0 9.18448 0 0 0 0 3.84388 0 0 8.77749 0 Q16667 CDKN3_HUMAN Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) CDKN3 CDI1 CIP2 KAP Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" KPPSSIQTSCKFK;TLIHCYGGLGR 2 14 0.97981 -1.8398 0 0 0 0 0 0 0 0 0 0 0 12.0379 Q16671 AMHR2_HUMAN Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII) AMHR2 AMHR MISR2 Homo sapiens (Human) anti-Mullerian hormone receptor signaling pathway [GO:1990262]; blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; Mullerian duct regression [GO:0001880]; sex differentiation [GO:0007548]; transforming growth factor beta receptor signaling pathway [GO:0007179] plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; anti-Mullerian hormone receptor activity [GO:1990272]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" AFPPRSVAQFQAER;AQVEMQGCRDSDEPGCESLHCDPSPR;GGPGRLLSGPLLVLELHPK;NPQPACTLSPV 4 12.2 0.97409 -2.4124 9.83976 7.93074 0 0 0 9.05075 0 0 8.17443 0 0 0 Q16674 MIA_HUMAN Melanoma-derived growth regulatory protein (Melanoma inhibitory activity protein) MIA Homo sapiens (Human) extracellular matrix organization [GO:0030198] extracellular space [GO:0005615] growth factor activity [GO:0008083] VDVKTDKWDFYCQ 1 9.9 0.86975 -0.091203 0 0 0 0 4.69159 0 0 0 0 0 0 0 Q16678 CP1B1_HUMAN Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1B1 Homo sapiens (Human) adrenal gland development [GO:0030325]; angiogenesis [GO:0001525]; arachidonate metabolic process [GO:0019369]; benzene-containing compound metabolic process [GO:0042537]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to cAMP [GO:0071320]; cellular response to cortisol stimulus [GO:0071387]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to organic cyclic compound [GO:0071407]; cellular response to progesterone stimulus [GO:0071393]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; collagen fibril organization [GO:0030199]; DNA modification [GO:0006304]; endothelial cell migration [GO:0043542]; endothelial cell-cell adhesion [GO:0071603]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; estrous cycle [GO:0044849]; ganglion development [GO:0061548]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; male gonad development [GO:0008584]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nitric oxide biosynthetic process [GO:0006809]; omega-hydroxylase P450 pathway [GO:0097267]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of translation [GO:0045727]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to 3-methylcholanthrene [GO:1904681]; response to arsenic-containing substance [GO:0046685]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to indole-3-methanol [GO:0071680]; response to nutrient [GO:0007584]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" CIGEELSK 1 1.5 0.93678 -0.55918 0 0 9.041 0 0 0 0 0 0 0 0 0 Q16696 CP2AD_HUMAN Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13) CYP2A13 Homo sapiens (Human) aflatoxin metabolic process [GO:0046222]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate epoxygenase activity [GO:0008392]; coumarin 7-hydroxylase activity [GO:0008389]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" DPRFFSNPRDFNPQHFLDK 1 3.8 0.96438 -1.1163 0 0 0 0 0 0 0 9.05262 8.78571 0 0 0 Q16698 DECR_HUMAN "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)" DECR1 DECR SDR18C1 Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; positive regulation of cold-induced thermogenesis [GO:0120162] catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; identical protein binding [GO:0042802]; NADPH binding [GO:0070402]" AGVEAMSKSLAAEWGK;FNVIQPGPIK;MDVLKATAEQISSQTGNK;VAFITGGGTGLGK 4 17 0.97195 -2.7993 0 0 0 0 0 0 0 10.8287 11.821 10.2934 0 0 Q16706 MA2A1_HUMAN "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A1 MANA2 Homo sapiens (Human) in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; protein glycosylation [GO:0006486]; respiratory gaseous exchange by respiratory system [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033]; viral protein processing [GO:0019082] cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]" AGLSHMLIQRVHYAVK;EIAMKISSDIKSQNR;QMMTKEDGK;TLEFFWR 4 4.1 0.97434 -3.6248 0 0 0 0 0 0 0 10.4291 0 8.43329 0 0 Q16719 KYNU_HUMAN Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) KYNU Homo sapiens (Human) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; L-kynurenine catabolic process [GO:0097053]; NAD biosynthetic process [GO:0009435]; quinolinate biosynthetic process [GO:0019805]; response to type II interferon [GO:0034341]; response to vitamin B6 [GO:0034516]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] kynureninase activity [GO:0030429]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] DENAIYFLGNSLGLQPK;EGEETLR;HFRECFYIPK;ISNPPILLVCSLHASLEIFK;MEPSSLELPADTVQR;VALHLDEEDK 6 17 0 5.1246 0 10.7206 10.1311 0 0 0 10.7463 10.8325 0 11.9622 9.7625 0 Q16760 DGKD_HUMAN Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) DGKD KIAA0145 Homo sapiens (Human) diacylglycerol catabolic process [GO:0046340]; diacylglycerol metabolic process [GO:0046339]; endocytosis [GO:0006897]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of phospholipase C/protein kinase C signal transduction [GO:0160195]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein transport [GO:0015031]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; diacylglycerol binding [GO:0019992]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] NMFLYFQTIIKEGMLTK;VCPPLSHSESFGVPK 2 2.7 0.9378 -0.57122 0 0 0 0 0 0 0 9.97083 0 0 0 0 Q16763 UBE2S_HUMAN Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) UBE2S E2EPF OK/SW-cl.73 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] DWTAELGIRHVLLTIKCLLIHPNPESALNEEAGR 1 15.3 0.85281 -0.079986 0 6.77109 0 0 0 0 0 11.1494 0 0 0 0 Q16769 QPCT_HUMAN Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) QPCT Homo sapiens (Human) "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]; protein modification process [GO:0036211]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270] RVVGTLHLLLLVAALPWASR 1 5.5 0.30501 0.24938 0 0 0 0 0 0 0 0 0 0 6.69293 0 Q16774 KGUA_HUMAN Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1) GUK1 GMK GMPK Homo sapiens (Human) dATP metabolic process [GO:0046060]; dGDP biosynthetic process [GO:0006185]; dGMP metabolic process [GO:0046054]; GDP biosynthetic process [GO:0046711]; GDP-mannose metabolic process [GO:0019673]; glycoprotein transport [GO:0034436]; nucleobase-containing small molecule interconversion [GO:0015949]; purine nucleotide metabolic process [GO:0006163]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] LAAAQADMESSK;QRNTETEESLVK 2 12.2 0.9658 -1.133 0 13.7608 0 0 0 0 0 0 0 0 0 0 Q16775 GLO2_HUMAN "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" HAGH GLO2 HAGH1 Homo sapiens (Human) glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] ALLEVLGR;FARHVEPGNAAIREK 2 7.5 0.9412 -0.60047 0 0 0 0 14.2567 0 0 7.04418 0 0 0 0 Q16775 GLO2_HUMAN "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" HAGH GLO2 HAGH1 Homo sapiens (Human) glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] SLPTTPS 1 3 0.67702 0.16578 0 0 0 9.53817 0 0 0 0 0 0 0 0 Q16787 LAMA3_HUMAN Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha) LAMA3 LAMNA Homo sapiens (Human) cell-cell adhesion [GO:0098609]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; hemidesmosome assembly [GO:0031581]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] adherens junction [GO:0005912]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; hemidesmosome [GO:0030056]; laminin-3 complex [GO:0005608]; laminin-5 complex [GO:0005610] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] ALGPVLPPTPLLLLVLR;CECQHHTCGETCDR;CECQHHTCGETCDRCCTGYNQR;CKPCSCGRR;CLCRPGVEGPR;DTYGRTQNEDFK;GCIELDDLNENVLSLYNFK;GCTSCFCFGVNNQCHSSHK;GRALGPVLPPTPLLLLVLR;ITGRQCDR;ITLNVGKSSGSLFRVILR;LLNEAKMTQK;MMRELRNR;SLEFITNCGK;VLVVPAENYDYQILHKK 15 5.5 0.97654 -4.9801 5.92041 10.6295 11.4848 10.1639 10.0279 0 0 12.2618 10.7577 10.4528 9.98142 8.29094 Q16798 MAON_HUMAN "NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)" ME3 Homo sapiens (Human) aerobic respiration [GO:0009060]; malate metabolic process [GO:0006108]; oxygen metabolic process [GO:0072592]; pyruvate metabolic process [GO:0006090] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADP+ binding [GO:0070401]; oxaloacetate decarboxylase activity [GO:0008948] VLDYAYK;VLDYAYKHNLASYYPEPK;YIILMTLQDRNEK 3 5.1 0.97876 -1.9185 0 0 0 8.55555 9.35381 0 8.38703 10.9256 0 0 0 0 Q16799 RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific protein) RTN1 NSP Homo sapiens (Human) brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] AIDLLYWR;DTDISIKPEGVR;GLFSSDSGIEMTPAESTEVNK;ILADPLDQMK 4 6.6 0.97452 -1.425 0 0 0 0 0 0 0 0 0 9.11715 8.1069 0 Q16816 PHKG1_HUMAN "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26)" PHKG1 PHKG Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycogen metabolic process [GO:0005977]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphorylase kinase activity [GO:0004689]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau-protein kinase activity [GO:0050321] AQGRARMK;TRDEALPDSHSAQDFYENYEPK 2 7.2 0.98058 -1.6745 0 0 0 0 0 0 0 0 0 7.31316 0 0 Q16819 MEP1A_HUMAN Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha) (PABA peptide hydrolase) (PPH alpha) MEP1A Homo sapiens (Human) epidermal growth factor receptor ligand maturation [GO:0038004]; signaling receptor ligand precursor processing [GO:0140448] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886] metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] LNRMYNCTTTHTLLDHCTFEK;LVVWVRR;LVVWVRRDDSTGNVR 3 4.8 0.97897 -1.9624 0 0 0 0 0 0 9.41445 0 0 10.066 0 9.3326 Q16820 MEP1B_HUMAN Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta) MEP1B Homo sapiens (Human) inflammatory response [GO:0006954]; proteolysis [GO:0006508] extracellular region [GO:0005576]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EIPTGSWQLYHVTLKVTK 1 2.6 0.82551 -0.020415 0 0 0 0 0 0 0 0 0 0 4.41183 0 Q16821 PPR3A_HUMAN Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) PPP1R3A PP1G Homo sapiens (Human) glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979] membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164] glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157] DVNREHDEHNEK;EIQGIEK;KHEGGAK;TNITEHIK 4 3 0.84531 -0.059502 0 0 0 0 8.01603 7.69279 7.15299 7.10014 10.5649 10.6875 9.30008 0 Q16822 PCKGM_HUMAN "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2)" PCK2 PEPCK2 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; NADH oxidation [GO:0006116]; oxaloacetate metabolic process [GO:0006107]; positive regulation of insulin secretion [GO:0032024]; propionate catabolic process [GO:0019543]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; phosphoenolpyruvate carboxykinase activity [GO:0004611] ETPIGLVPK 1 1.4 0.0125 0.90804 10.4838 10.0511 0 0 0 0 0 0 0 0 0 0 Q16825 PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) PTPN21 PTPD1 Homo sapiens (Human) protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LEQGMVFTEYERILK;NGRHPVVFRWHDIANMSHNK;RLVDGECSTARLPENAER 3 4.5 0.9553 -0.8287 0 0 0 0 6.54424 0 0 0 10.5814 0 0 7.07243 Q16827 PTPRO_HUMAN Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2) PTPRO GLEPP1 PTPU2 Homo sapiens (Human) axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; podocyte differentiation [GO:0072112]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060] apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]" LPYNWSKNGLK 1 2.9 0.92175 -0.44513 0 0 0 0 0 0 0 0 8.19574 0 0 0 Q16831 UPP1_HUMAN Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; nucleobase-containing compound metabolic process [GO:0006139]; UMP catabolic process [GO:0046050]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218] cytosol [GO:0005829]; nucleoplasm [GO:0005654] deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850] LEGDQISSPR;LLNPNIAKMKEDILYHFNLTTSR;LVSYFIK;LVSYFIKK 4 13.2 0.97432 -2.4553 0 0 0 8.09693 0 0 12.4544 10.5698 0 0 10.4745 10.5503 Q16832 DDR2_HUMAN "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" DDR2 NTRKR3 TKT TYRO10 Homo sapiens (Human) biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; collagen binding [GO:0005518]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DKDFALDVSANQPVLVAVKMLR;ILIGCLVAIIFILLAIIVIILWR;NFTTMKVHCNNMFAK 3 7 0.20548 0.32804 0 4.4367 7.66313 0 5.92036 0 0 0 0 5.18257 0 0 Q16836 HCDH_HUMAN "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)" HADH HAD HAD1 HADHSC SCHAD Homo sapiens (Human) cell differentiation [GO:0030154]; fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; transferase activity [GO:0016740] DFQTCGDSNSGLGFSLK;LVAENKFGK 2 6.7 0.96745 -1.3058 0 0 0 0 0 0 0 0 0 0 7.68699 0 Q16842 SIA4B_HUMAN "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B)" ST3GAL2 SIAT4B Homo sapiens (Human) ganglioside biosynthetic process via lactosylceramide [GO:0010706]; globoside biosynthetic process via lactosylceramide [GO:0010707]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; protein homodimerization activity [GO:0042803]; sialyltransferase activity [GO:0008373]" LSKERLSGK 1 2.6 0.97497 -1.4307 0 0 0 0 0 0 0 0 0 0 0 14.0858 Q16851 UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 UGP1 Homo sapiens (Human) brain development [GO:0007420]; glucose 1-phosphate metabolic process [GO:0019255]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; UDP-alpha-D-glucose metabolic process [GO:0006011]; UDP-glucuronate biosynthetic process [GO:0006065] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] D-glucose binding [GO:0005536]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyrimidine ribonucleotide binding [GO:0032557]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983] EFPTVPLVK;GGTLTQYEGK;IQRPPEDSIQPYEK;LVEIAQVPK;LVEIAQVPKAHVDEFK 5 9.6 0.91068 -0.29159 14.8523 9.48973 14.1975 0 9.67138 0 0 0 0 0 8.97811 0 Q16853 AOC3_HUMAN Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) AOC3 VAP1 Homo sapiens (Human) amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] aliphatic amine oxidase activity [GO:0052595]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; primary methylamine oxidase activity [GO:0008131]; protein heterodimerization activity [GO:0046982]; quinone binding [GO:0048038] TILVLLILAVITIFALVCVLLVGR 1 3.1 0.90876 -0.30793 0 0 0 0 0 0 0 10.0388 0 0 0 0 Q16875 F263_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB3 Homo sapiens (Human) "apoptotic process [GO:0006915]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glial cell differentiation [GO:0010001]; glycolytic process [GO:0006096]; motor behavior [GO:0061744]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" CLLAYFLDK;DCNSAEAMDDFMK;IVYYLMNIHVQPR;TIYLCRHGENEHNLQGRIGGDSGLSSR 4 11.9 0.9512 -0.68893 0 0 0 0 0 0 0 0 10.9238 14.1313 10.552 12.5412 Q16877 F264_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB4 Homo sapiens (Human) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" cytosol [GO:0005829] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" CLLAYFLDK;SLAQFISDQNIKDLK 2 5.1 0.91707 -0.42863 0 0 0 8.59518 0 0 0 0 0 0 0 0 Q16878 CDO1_HUMAN Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) CDO1 Homo sapiens (Human) cysteine metabolic process [GO:0006534]; inflammatory response [GO:0006954]; L-cysteine catabolic process [GO:0019448]; lactation [GO:0007595]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; sulfur amino acid biosynthetic process [GO:0000097]; taurine biosynthetic process [GO:0042412] cytosol [GO:0005829] cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] TLADLIR 1 3.5 0.883 -0.17508 0 0 0 0 0 0 0 0 10.0876 0 7.84442 0 Q16880 CGT_HUMAN 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47) (Ceramide UDP-galactosyltransferase) (Cerebroside synthase) (UDP-galactose-ceramide galactosyltransferase) UGT8 CGT UGT4 Homo sapiens (Human) central nervous system development [GO:0007417]; cytoskeleton organization [GO:0007010]; galactosylceramide biosynthetic process [GO:0006682]; glycosphingolipid biosynthetic process [GO:0006688]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to paranode region of axon [GO:0002175]; response to immobilization stress [GO:0035902] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "N-acylsphingosine galactosyltransferase activity [GO:0003851]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]" AQKLSEIHK 1 1.7 0.98041 -1.5522 0 0 10.1881 7.57886 0 0 0 0 0 8.97022 8.71805 0 Q16881 TRXR1_HUMAN "Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)" TXNRD1 GRIM12 KDRF Homo sapiens (Human) cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; mesoderm formation [GO:0001707]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] FAD binding [GO:0071949]; identical protein binding [GO:0042802]; NADPH peroxidase activity [GO:0050137]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] EAAQYGK;IGLETVGVK;INEKTGK;MNGPEDLPK;VEQIEAGTPGR;VMVLDFVTPTPLGTR;VVAQSTNSEEIIEGEYNTVMLAIGR 7 12.8 0 2.1542 0 11.9391 0 0 0 0 9.85371 9.63778 10.2798 0 0 0 Q16891 MIC60_HUMAN MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) IMMT HMP MIC60 MINOS2 PIG4 PIG52 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050] membrane [GO:0016020]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] RNA binding [GO:0003723] AVDEAADALLK;ELDSITPEVLPGWK;FVLRPLRPCRR;GVYSEETLR;ISSVSEVMK;LSEQELQFR;QPASQLQK;SEIQAEQDR;TVEGALK;VAQDWLK;VQEQELK;VVSQYHELVVQARDDFK 12 15.6 0.9741 -2.4185 13.3788 9.88608 3.05283 7.39541 11.1253 0 11.8362 8.39789 0 9.29402 11.2576 11.515 Q17R55 F187B_HUMAN Protein FAM187B (Transmembrane protein 162) FAM187B TMEM162 Homo sapiens (Human) membrane [GO:0016020] ANDTPLTWESQLSGQDFTTFLDPSTGGR;CIHPSPGR;GLKLVLLVVTVLALLGALLK 3 15.2 0.95235 -0.70873 0 0 8.85941 9.58065 0 5.82706 5.21653 0 0 0 0 0 Q17R60 IMPG1_HUMAN Interphotoreceptor matrix proteoglycan 1 (Interphotoreceptor matrix proteoglycan of 150 kDa) (IPM-150) (Sialoprotein associated with cones and rods) IMPG1 IPM150 SPACR Homo sapiens (Human) extracellular matrix organization [GO:0030198]; visual perception [GO:0007601] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] chondroitin sulfate binding [GO:0035374]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540] GRELVVFFSLR 1 1.4 0.88496 -0.18108 0 0 0 0 0 8.42844 0 0 0 0 0 0 Q17R98 ZN827_HUMAN Zinc finger protein 827 ZNF827 Homo sapiens (Human) chromatin remodeling [GO:0006338]; establishment of protein localization to telomere [GO:0070200]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of shelterin complex assembly [GO:1904791]; positive regulation of transcription by RNA polymerase II [GO:0045944]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]" DNA binding [GO:0003677]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325] DDSDGSQK;EPMNLNFK;LSAANQK 3 2.1 0.95521 -0.97188 0 0 0 0 0 0 0 0 0 8.65882 0 3.64685 Q17RB0 RTL8B_HUMAN Retrotransposon Gag-like protein 8B (Mammalian retrotransposon derived protein 8B) RTL8B CXX1C FAM127C MAR8B Homo sapiens (Human) ALLARPLRPAARRWR 1 13.3 0.86459 -0.083908 0 0 0 0 0 0 0 0 0 3.10076 0 0 Q17RB8 LONF1_HUMAN LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) LONRF1 RNF191 Homo sapiens (Human) cytosol [GO:0005829] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GSLNRAQSAQSINSTEMPAR;GVLLKRK;LERAAAESERWELLLR 3 5.6 0.91545 -0.33298 6.00964 0 0 7.60711 0 0 8.76792 0 0 0 0 0 Q17RC7 EX3L4_HUMAN Exocyst complex component 3-like protein 4 EXOC3L4 C14orf73 Homo sapiens (Human) exocyst localization [GO:0051601]; exocytosis [GO:0006887] exocyst [GO:0000145] SNARE binding [GO:0000149] AAAGAAGAEAPRGR;VLFEEIKVPSAMAVLITCV 2 4.6 0.98058 -1.7503 0 10.8081 0 0 0 0 0 0 0 0 0 0 Q17RD7 SYT16_HUMAN Synaptotagmin-16 (Chr14Syt) (Synaptotagmin 14-like protein) (Synaptotagmin XIV-related protein) SYT16 STREP14 SYT14L SYT14R Homo sapiens (Human) identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] RNRTGPICR 1 2.3 0.97691 -1.4949 0 0 0 0 8.71112 0 0 0 0 0 0 0 Q17RF5 ODAPH_HUMAN Odontogenesis associated phosphoprotein ODAPH C4orf26 Homo sapiens (Human) positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175] extracellular region [GO:0005576] IHFRFPNRPFVPSRCNHR 1 13.8 0.51471 0.18756 0 0 0 7.78816 0 0 0 0 0 0 0 0 Q17RG1 KCD19_HUMAN BTB/POZ domain-containing protein KCTD19 (Potassium channel tetramerization domain-containing protein 19) KCTD19 Homo sapiens (Human) cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260]; spermatogenesis [GO:0007283] nucleus [GO:0005634] identical protein binding [GO:0042802] DITYEPIK;HHLRVRPADLPVAER;LSQFPDSLLWK;MNMGGCSPTTCSPLSPGKGAR 4 5.9 0.97117 -1.3424 0 5.48591 0 0 0 0 0 0 0 10.8053 0 0 Q17RM4 CC142_HUMAN Coiled-coil domain-containing protein 142 CCDC142 PSEC0243 Homo sapiens (Human) LDEALQGSALRDQLR;SGSLPPLVIVPPLR 2 4.4 0.94574 -0.65222 0 5.70578 0 0 0 0 0 0 0 9.00492 0 0 Q17RN3 FA98C_HUMAN Protein FAM98C FAM98C Homo sapiens (Human) tRNA-splicing ligase complex [GO:0072669] DQYRCRR;EDGGPQCWGRK 2 5.2 0.97879 -1.9687 0 0 0 0 0 10.223 0 9.1128 0 0 0 0 Q17RP2 TIGD6_HUMAN Tigger transposable element-derived protein 6 TIGD6 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] LTALFCCNASGTEK;QAIDMIAAAWWSVKPSTVVK;SALYDDIDKAVFAWFQEIHAKNILVTGSVIR 3 12.5 0.35391 0.23451 0 7.14802 0 0 0 4.34604 0 0 0 7.13894 0 0 Q17RQ9 NKPD1_HUMAN NTPase KAP family P-loop domain-containing protein 1 NKPD1 Homo sapiens (Human) membrane [GO:0016020] ANSASRAPPSGR;DNSRELHTMTK;IDDEAARR;LQFLHDAVQSR 4 6.9 0.97488 -3.4562 0 0 0 4.23925 3.00105 0 0 0 0 0 11.0146 0 Q17RR3 LIPR3_HUMAN Pancreatic lipase-related protein 3 (PL-RP3) (EC 3.1.1.3) PNLIPRP3 Homo sapiens (Human) lipid catabolic process [GO:0016042] extracellular region [GO:0005576] triacylglycerol lipase activity [GO:0004806] EVCYERLGCFK;KTGEFAIVSGKLEPGMTYTK;VVGAEVAYFIDVLMKK 3 10.1 0.94223 -0.59577 0 5.67358 8.7938 0 0 0 0 0 11.0291 0 5.91375 0 Q17RS7 GEN_HUMAN Flap endonuclease GEN homolog 1 (EC 3.1.-.-) GEN1 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; resolution of mitotic recombination intermediates [GO:0071140] centrosome [GO:0005813]; nucleoplasm [GO:0005654] 5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] QLSEVENNIKKK;YCEPHDYEYCCPCEWHR 2 3.2 0.95416 -0.88714 0 0 9.50249 0 5.27769 0 0 0 0 0 0 0 Q17RW2 COOA1_HUMAN Collagen alpha-1(XXIV) chain COL24A1 Homo sapiens (Human) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] LQLGVQLLPKKLVVHIR 1 1 0.56231 0.18254 6.8896 0 0 0 0 6.18408 0 0 0 0 0 0 Q17RY6 LY6K_HUMAN Lymphocyte antigen 6K (Ly-6K) LY6K CO16 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339] acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ALLALLLVVALPR;ENTFECQNPRR;TDEGDNRVWCHVCER 3 37.1 0.84796 -0.076815 0 7.76102 0 9.97556 0 8.09175 0 0 0 4.97278 0 0 Q1A5X6 IQCJ_HUMAN IQ domain-containing protein J IQCJ Homo sapiens (Human) RLEELKR;SPSPPSVSSEK 2 11.3 0.98037 -1.7127 0 0 0 12.4147 0 0 0 0 0 0 8.70151 0 Q1AE95 T183B_HUMAN Putative transmembrane protein 183BP (Transmembrane protein 183B pseudogene) TMEM183BP C1orf37-dup TMEM183B Homo sapiens (Human) regulation of protein stability [GO:0031647] membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005] AHDACSGR;ISKNPAIPESTPSTLK 2 6.4 0.95448 -0.82164 0 0 7.72853 0 0 0 0 0 0 6.87627 0 0 Q1EHB4 SC5AC_HUMAN Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) SLC5A12 SMCT2 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]; symporter activity [GO:0015293] ESLVHVPGYDPK 1 1.9 0.80412 0.012812 0 0 0 0 0 0 0 0 0 7.75956 0 0 Q1HG43 DOXA1_HUMAN Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) hydrogen peroxide metabolic process [GO:0042743]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] cell leading edge [GO:0031252]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] enzyme binding [GO:0019899] ACGVRAMLPR 1 2.1 0.96483 -1.2301 0 0 0 0 0 0 2.37209 3.71501 0 0 0 12.0702 Q1KMD3 HNRL2_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) HNRNPUL2 HNRPUL2 Homo sapiens (Human) membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] RNA binding [GO:0003723] LVQIASR;LVQIASRTKR;NCVVELNFGQK;STYGVTK;YGGQPLFSEK;YNVLGAETVLNQMR 6 7 0.96623 -1.2628 0 0 0 0 9.49075 0 10.0575 0 0 0 7.58931 10.1914 Q1L5Z9 LONF2_HUMAN LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192) LONRF2 RNF192 Homo sapiens (Human) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] CFPAECR;LGDALAR 2 1.9 0.58932 0.17896 0 0 14.3411 11.2107 10.1911 0 0 0 0 0 8.09603 12.0463 Q1MSJ5 CSPP1_HUMAN Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819]; spindle pole [GO:0000922] EELRQDYR;IAEEKEERR;LAEDKAELESDPPYMEMKGK;VDLDAIPSAKVR;VDLDAIPSAKVREQR 5 4.1 0.954 -0.91649 0 0 0 9.77624 0 8.05289 0 10.3175 10.419 0 0 0 Q1RMZ1 SAMTR_HUMAN S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) SAMTOR BMT2 C7orf60 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to methionine [GO:0061431]; methylation [GO:0032259]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263]; regulation of TORC1 signaling [GO:1903432] cytosol [GO:0005829] methyltransferase activity [GO:0008168]; protein-containing complex binding [GO:0044877]; S-adenosyl-L-methionine binding [GO:1904047] FSHMHLMAFR;IEWCCSVCREYFQNGGK;KISLKTTSDLVSR;LLDVGSCFNPFLK 4 13.1 0.95248 -0.74072 0 0 0 0 0 0 9.19288 0 0 0 10.6604 0 Q1X8D7 LRC36_HUMAN Leucine-rich repeat-containing protein 36 (ROR gamma-binding protein 70) LRRC36 RORBP70 Homo sapiens (Human) AFCRRELELK;ALLPPEK;ELIPKPDTFHLTHDASLSK 3 4.8 0.26683 0.26308 0 8.74524 0 5.57262 12.9386 11.8525 0 13.1655 9.43602 6.83731 12.767 0 Q1XH10 SKDA1_HUMAN SKI/DACH domain-containing protein 1 (Protein DLN-1) SKIDA1 C10orf140 DLN1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700] WQLGGSAIPLPPSHK 1 1.7 0.78372 0.030634 0 0 0 0 0 0 0 0 10.7496 0 0 0 Q1ZZU3 SWI5_HUMAN DNA repair protein SWI5 homolog (HBV DNAPTP1-transactivated protein A) (Protein SAE3 homolog) SWI5 C9orf119 SAE3 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; double-strand break repair via homologous recombination [GO:0000724] nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]; Swi5-Swi2 complex [GO:0034974] DLWRHNK 1 3 0.89929 -0.25794 0 0 0 0 0 0 10.1577 0 0 0 0 0 Q24JP5 T132A_HUMAN Transmembrane protein 132A (HSPA5-binding protein 1) TMEM132A HSPA5BP1 KIAA1583 Homo sapiens (Human) negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] VASLEGGRVVVGREPGVTSIEVR 1 2.2 0.9586 -1.0024 0 0 0 10.2899 0 0 0 0 0 0 0 0 Q24JP5 T132A_HUMAN Transmembrane protein 132A (HSPA5-binding protein 1) TMEM132A HSPA5BP1 KIAA1583 Homo sapiens (Human) negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] VRRPPSLPGKAGGQVPGAP 1 4.6 0.51106 0.18763 0 0 0 7.43263 0 7.4494 0 0 0 0 0 0 Q27J81 INF2_HUMAN Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140] actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779]; small GTPase binding [GO:0031267] ALDELFEAIEQK;CSNEEVAAMIRAGDTTKFDVEVLK;LGPQDSDPTEANLESADPELCIR;SLNLNIFLK;TVCSQQYR 5 6.1 0.9531 -0.7353 5.36622 7.25125 0 0 0 0 0 0 0 8.05284 0 14.5732 Q29RF7 PDS5A_HUMAN Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) PDS5A KIAA0648 PDS5 PIG54 Homo sapiens (Human) cell division [GO:0051301]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of DNA replication [GO:0008156] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]" ALVKLLLPLEYMAIFALCAK;DLALVNDQLLGFVR;ERRAHAR;IISVTPVKNIDPVKNK;LAAGSAIMK;LLHIYYQNSIDDK;LTRDAQSPDESKTNEK;NIDPVKNK;QIFAQKLHKALVK;TLFSVINNSHNK 10 8.7 0.97637 -5.0034 0 10.4782 0 0 7.63988 0 0 12.1088 0 5.85917 0 10.663 Q2HXU8 CL12B_HUMAN C-type lectin domain family 12 member B (Macrophage antigen H) CLEC12B UNQ5782/PRO16089 Homo sapiens (Human) melanocyte proliferation [GO:0097325]; natural killer cell inhibitory signaling pathway [GO:0002769]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of signaling receptor activity [GO:2000272] external side of plasma membrane [GO:0009897]; protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547] DCIDKNSTLVKIDSLEEK;LCQELIIHTSDHR;TWANSRKDCIDK 3 13.8 0.98054 -2.0152 0 0 0 0 0 9.28628 0 11.0027 0 0 0 0 Q2I0M5 RSPO4_HUMAN R-spondin-4 (Roof plate-specific spondin-4) (hRspo4) RSPO4 C20orf182 Homo sapiens (Human) nail development [GO:0035878]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576]; extracellular space [GO:0005615] heparin binding [GO:0008201]; signaling receptor binding [GO:0005102] RQFYLYK 1 3 0.93356 -0.5078 0 0 0 0 0 0 0 0 0 0 10.183 0 Q2KHM9 MOONR_HUMAN Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) KIAA0753 MNR OFIP Homo sapiens (Human) centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" QSQPHSK 1 0.7 0.90994 -0.31529 0 0 0 0 0 0 0 8.0614 0 0 0 0 Q2KHN1 RN151_HUMAN RING finger protein 151 RNF151 Homo sapiens (Human) cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GHQDSCPFELTACPNEGCTSQVPR 1 9.8 0.70985 0.15634 0 0 0 0 0 0 0 0 0 5.28481 0 0 Q2KHR2 RFX7_HUMAN DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) RFX7 RFXDC2 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]" DPKLCTK;LVCEWAQK 2 1 0.98091 -1.594 0 0 0 0 0 0 0 0 9.09958 0 10.2277 0 Q2KHR3 QSER1_HUMAN Glutamine and serine-rich protein 1 QSER1 Homo sapiens (Human) chromosome [GO:0005694] ALLQKFVPEIRDGQR;FVPEIRDGQR;GKGQVKEEDNSNQK;MNGKAYNK;MPNRTRRPGTQMVR;TGFIASFLDFLK;VQKALLQKFVPEIR 7 3.8 0.97576 -4.3077 0 0 0 0 8.16867 0 8.14919 10.1034 7.84166 0 8.46634 0 Q2KJY2 KI26B_HUMAN Kinesin-like protein KIF26B KIF26B Homo sapiens (Human) establishment of cell polarity [GO:0030010]; microtubule-based movement [GO:0007018]; positive regulation of cell-cell adhesion [GO:0022409]; ureteric bud invasion [GO:0072092] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GTPPLPPVRK;KPPNSTGVR;LEQLASR;NIQEPEAPTATPK;RRLIPALSLDTSSPVR;RSHQQDCDEDDHR;SHQQDCDEDDHR;TNGVTLYPYQISQLMTESSR 8 4.2 0.95687 -0.84933 13.4165 0 9.91202 0 0 0 9.86248 10.7103 0 0 0 2.4837 Q2LD37 BLTP1_HUMAN Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) BLTP1 FSA KIAA1109 KIAA1371 TWEEK Homo sapiens (Human) endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intermembrane lipid transfer [GO:0120009]; phagocytosis [GO:0006909]; regulation of cell growth [GO:0001558]; regulation of epithelial cell differentiation [GO:0030856]; synaptic vesicle endocytosis [GO:0048488] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] phosphatidylethanolamine transfer activity [GO:1904121] AGMPVKDSPRK;AVLFWLNYK;DSLSKTSTPFNKSNK;EAVQNSKTTFSENLSSK;EIAAKLNIHRVHGQLR;EIGRTRTQSK;EKAIFPPR;LHYNSKTLKTESPNASR;LIHQFSTMIDDIK;LSVGSNR;RTNNENNKK;SEIFVHGDLKWDIFQVMISRSTTPDLIK;SLSGTATER;SQGRLSVGSNRDR;TMTSNLEK;TSNFDRYVHATK 16 3.9 0.9787 -8.8452 11.5869 0 10.0497 7.45607 0 12.2881 0 10.1645 11.7724 10.8016 8.93537 12.0415 Q2LD37 BLTP1_HUMAN Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) BLTP1 FSA KIAA1109 KIAA1371 TWEEK Homo sapiens (Human) endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intermembrane lipid transfer [GO:0120009]; phagocytosis [GO:0006909]; regulation of cell growth [GO:0001558]; regulation of epithelial cell differentiation [GO:0030856]; synaptic vesicle endocytosis [GO:0048488] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] phosphatidylethanolamine transfer activity [GO:1904121] AGMPVKDSPRK;AVLFWLNYK;EAVQNSKTTFSENLSSK;EIAAKLNIHRVHGQLR;EIGRTRTQSK;LIHQFSTMIDDIK;RTNNENNKK;TSNFDRYVHATK;VTFNIQDTIAEIRR 9 3 0.87628 -0.13132 0 0 0 0 0 0 0 0 0 0 0 11.7351 Q2M1K9 ZN423_HUMAN Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) ZNF423 KIAA0760 NPHP14 OAZ Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" CALCLKEFRSK;CTACNWDFR 2 1.6 0.98101 -1.7511 0 0 7.89251 0 0 0 0 0 0 0 0 0 Q2M1P5 KIF7_HUMAN Kinesin-like protein KIF7 KIF7 UNQ340/PRO539 Homo sapiens (Human) microtubule-based movement [GO:0007018]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880] ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AAQALNR;AMAEAFK;DFLAALEDAMEQYK;EKKQATER;ELGRYMWINQELKQK;ELRRASPGMIDVR;NEAITCRQRVLR;RTLHLRR 8 6.2 0.97615 -4.5983 0 0 10.3172 0 0 0 0 0 0 11.0402 0 11.7148 Q2M1Z3 RHG31_HUMAN Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) ARHGAP31 CDGAP KIAA1204 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027] GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] AVPEAPGTVECSK;IQNVIQELPPSHYR;LSSKSKK;NSAPVSVSAVRTSFMVK;QEFGSDQCPDLTR 5 4.4 0.97999 -1.8298 0 0 7.80142 0 0 0 0 0 0 0 8.83703 0 Q2M218 ZN630_HUMAN Zinc finger protein 630 ZNF630 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSLKSHLILHQR;LEHGKDPWIIESELSR 2 4.4 0.96468 -1.1185 0 0 5.60981 0 0 0 10.3247 0 0 8.9289 0 0 Q2M238 RN3P1_HUMAN Putative RRN3-like protein RRN3P1 (RNA polymerase I transcription factor homolog pseudogene 1) RRN3P1 Homo sapiens (Human) transcription initiation at RNA polymerase I promoter [GO:0006361] RNA polymerase I general transcription initiation factor activity [GO:0001181] ICLPSVVNFFAAITKMK 1 11.2 0.94595 -0.65218 0 0 0 0 0 0 0 10.7195 0 0 0 0 Q2M243 CCD27_HUMAN Coiled-coil domain-containing protein 27 CCDC27 Homo sapiens (Human) EASPSQRHSSMSSSMAR 1 2.6 0.97509 -1.4346 0 12.0641 0 7.37972 11.9154 0 0 0 0 0 12.9849 12.4766 Q2M296 MTHSD_HUMAN Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Homo sapiens (Human) cytoplasm [GO:0005737] RNA binding [GO:0003723] DLDVFARTQEVK;LLVLQSKKTLLVPTPR 2 7.3 0.97518 -1.3912 4.59066 0 0 0 0 0 0 0 0 0 0 10.2822 Q2M2H8 MGAL_HUMAN "Probable maltase-glucoamylase 2 (Maltase-glucoamylase (alpha-glucosidase) pseudogene) [Includes: Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; glucan 1,4-alpha-glucosidase activity [GO:0004339]" AYVAFPDFFRNSTAAWWK;FNCYPDDPTASEESCR;VIYHTATMLQVKIYDPTNK;VLLDTSIGPLQFAQQYLQLSFR;WYDYSTGTSSTSTGQRKILK 5 3.8 0.41863 0.19804 8.6466 0 7.18933 0 6.59249 7.73931 8.35913 0 0 0 0 0 Q2M2I8 AAK1_HUMAN AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 KIAA1048 Homo sapiens (Human) membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; presynaptic endocytosis [GO:0140238]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880] cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; terminal bouton [GO:0043195] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GGQVVNLMNQR;MFVNNEHDLQVCKREIQIMR 2 3.2 0.98157 -1.5792 0 0 0 0 0 9.2957 11.2641 0 0 0 0 0 Q2M2W7 CQ058_HUMAN UPF0450 protein C17orf58 C17orf58 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023] EPASEDAPR;LAQAENR;TSPPHSR 3 6.8 0.9407 -0.58545 0 0 0 0 0 0 0 8.74796 8.85178 9.54119 7.17582 0 Q2M2Z5 KIZ_HUMAN Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) KIZ C20orf19 NCRNA00153 PLK1S1 HT013 Homo sapiens (Human) spindle organization [GO:0007051] cell projection [GO:0042995]; centrosome [GO:0005813]; cytoplasm [GO:0005737] protein kinase binding [GO:0019901] LDLEKKLYEYNQSDTCR;RSAIHSSESSCSLPSILNDNSGIK 2 6.1 0.39528 0.21159 0 0 0 6.98413 0 0 0 0 0 11.5492 0 0 Q2M329 CF184_HUMAN Cilia- and flagella-associated protein 184 CFAP184 CCDC96 Homo sapiens (Human) cilium assembly [GO:0060271] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064] IENQTFNEKIEER;LHFMDMENACKK;QSLVHFETRMR;SKVTNSVQVITHVKEK 4 9.4 0.93525 -0.52969 0 11.9317 0 6.17881 3.0184 0 0 0 10.1924 0 0 0 Q2M385 MPEG1_HUMAN "Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]" MPEG1 Homo sapiens (Human) adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474] wide pore channel activity [GO:0022829] ATILFWAAAAWAK;KCTLLVFCK;NLVYTVKINPTLELSSGFRK 3 5.9 0.91019 -0.28895 0 0 0 0 0 3.60146 0 0 0 0 10.544 0 Q2M389 WASC4_HUMAN WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) WASHC4 KIAA1033 Homo sapiens (Human) cognition [GO:0050890]; endolysosomal toll-like receptor signaling pathway [GO:0140894]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; neuromuscular process [GO:0050905]; nuclear envelope budding [GO:0140591]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein complex stability [GO:0061635] early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203] DHWTMYKRLLK;IFFRADKTAAEENQEK;LDVYLQEFELLYFSLSSAR 3 3.9 0.97529 -1.447 5.74446 0 0 0 0 7.69558 0 10.0945 10.8986 0 0 0 Q2M3C6 TM266_HUMAN Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1) TMEM266 C15orf27 HVRP1 Homo sapiens (Human) cytosol [GO:0005829]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] EGSNWLKPCCGKR 1 2.4 0.34922 0.23591 0 0 0 0 0 0 0 6.01156 0 0 0 0 Q2M3C7 SPKAP_HUMAN A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein) SPHKAP KIAA1678 SKIP Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] protein kinase A binding [GO:0051018] NPTLQSQLSRSHR;RGSEFLMTPNVPCRSLK;SPHHSENECR;SPHHSENECRASSEGQR;VGDIFHAVVQYCKMHEEQK;WLYALEDK 6 4.4 0.9801 -1.7172 0 0 0 5.07481 9.54678 0 10.7137 11.1059 0 0 0 4.37719 Q2M3D2 EX3L2_HUMAN Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7) EXOC3L2 XTP7 Homo sapiens (Human) exocytosis [GO:0006887] exocyst [GO:0000145] AGSPGDGQPR;GGAPGPPK;GLEDECVTDVK;LGWAPGR;VLVPGIR 5 5.4 0.96123 -1.0598 0 0 0 0 0 4.5799 0 0 0 0 7.62227 0 Q2M3G0 ABCB5_HUMAN ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2) ABCB5 Homo sapiens (Human) cell differentiation [GO:0030154]; eye development [GO:0001654]; regulation of membrane potential [GO:0042391]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562] EANAYDFIMEFPNK;ELNVQWLR;TCLVVTHR 3 2.4 0.95978 -1.0534 0 0 0 0 0 9.43784 0 4.32229 0 0 0 10.5723 Q2M3G4 SHRM1_HUMAN Protein Shroom1 (Apical protein 2) SHROOM1 APXL2 KIAA1960 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; cell morphogenesis [GO:0000902] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; microtubule [GO:0005874] actin filament binding [GO:0051015]; myosin II binding [GO:0045159] LLQRQEEDAK;VLGLLLLLGSRLARVR 2 3.1 0.97386 -1.4044 0 0 0 10.774 0 0 0 0 0 0 9.88956 0 Q2M3R5 S35G1_HUMAN Solute carrier family 35 member G1 (Partner of STIM1) (Transmembrane protein 20) SLC35G1 C10orf60 POST TMEM20 Homo sapiens (Human) calcium ion export across plasma membrane [GO:1990034]; regulation of cytosolic calcium ion concentration [GO:0051480] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] KTGFIGPK 1 2.2 0.90976 -0.31817 0 0 0 0 11.2268 0 0 0 0 0 0 0 Q2M3T9 HYAL4_HUMAN Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4) HYAL4 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan catabolic process [GO:0030214] cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020] hyalurononglucosaminidase activity [GO:0004415] DVYRQKSR;ISTMTSHDYALPVFVYTR;SLGDSENILR 3 7.5 0.97724 -1.4991 0 11.8609 11.7729 0 0 0 7.85599 0 0 0 0 10.4659 Q2M3W8 ZN181_HUMAN Zinc finger protein 181 (HHZ181) ZNF181 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPWMMEKKLSK;QSYEFSNSKK 2 3.7 0.68207 0.16492 0 0 0 0 0 0 3.55029 0 0 0 0 0 Q2M5E4 RGS21_HUMAN Regulator of G-protein signaling 21 (RGS21) RGS21 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]; transmission of nerve impulse [GO:0019226] plasma membrane [GO:0005886] GTPase activity [GO:0003924] IFLKSEFSEENVEFWLACEDFK;LIYCLMAK 2 19.7 0.91109 -0.28561 12.6283 8.57497 13.7247 0 0 0 0 6.98709 0 0 0 0 Q2MV58 TECT1_HUMAN Tectonic-1 TCTN1 TECT1 UNQ9369/PRO34160 Homo sapiens (Human) central nervous system interneuron axonogenesis [GO:0021956]; cilium assembly [GO:0060271]; dorsal/ventral neural tube patterning [GO:0021904]; in utero embryonic development [GO:0001701]; neural tube formation [GO:0001841]; protein localization to ciliary transition zone [GO:1904491]; regulation of smoothened signaling pathway [GO:0008589]; somatic motor neuron differentiation [GO:0021523]; telencephalon development [GO:0021537] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; MKS complex [GO:0036038] GSLEVPDSR;TPVLFGYTMQSGCKLR;VPITVQSIVIQSLNK 3 7 0.95485 -0.94828 8.30784 0 0 0 9.41005 10.1893 0 0 0 0 0 0 Q2NKJ3 CTC1_HUMAN CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) CTC1 C17orf68 Homo sapiens (Human) bone marrow development [GO:0048539]; DNA damage response [GO:0006974]; hematopoietic stem cell proliferation [GO:0071425]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; spleen development [GO:0048536]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; thymus development [GO:0048538] "chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162] LAWSWLCLLPSAFCPAQVLLGVLVASSHK;QHVWMTSQSSR;QLGLPLYLWATKALEELACKLCPHVLR 3 5.5 0.735 0.11071 0 0 8.23621 0 0 0 9.91028 10.1851 0 0 0 7.84793 Q2NKQ1 SGSM1_HUMAN Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) SGSM1 KIAA1941 RUTBC2 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] CDRNYWYFTPANLEK;KLPKLPNLSPLAIK 2 2.5 0.89795 -0.25495 0 10.5952 0 3.99068 0 3.46793 0 0 0 0 0 0 Q2NKX8 ERC6L_HUMAN DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) ERCC6L PICH Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] IDGTVTHLLER;IKTSSTK;NEGAWLR;NPFRYFSK;TFHGPSK 5 3.2 0.97269 -2.5981 10.2498 10.7277 8.12221 0 0 0 0 0 0 10.1241 0 10.2853 Q2NL67 PARP6_HUMAN Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6) PARP6 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of dendrite morphogenesis [GO:0050775]; protein auto-ADP-ribosylation [GO:0070213] endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539] HPQLDADIEAVK;SISCTMKNPK 2 3.5 0.97853 -1.9748 10.3505 0 0 11.832 0 0 0 0 0 0 0 0 Q2NL68 PRSR3_HUMAN Proline and serine-rich protein 3 PROSER3 C19orf55 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737] QAQPTSREER 1 2.1 0.88577 -0.18159 0 0 0 0 0 0 9.40248 0 0 0 0 0 Q2NL82 TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog TSR1 KIAA1401 Homo sapiens (Human) "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] AKEELIFHCGFR;GQTLNVNR;HRWFFTSARPGDLHVVLDMAK;IFQFQNFTNTR;QLANQKQQHLAFRDR;WGRRGHIK 6 9.3 0.97455 -3.6619 10.8436 0 13.7162 0 0 9.63452 0 0 0 9.09693 0 7.99921 Q2PPJ7 RGPA2_HUMAN Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) RALGAPA2 C20orf74 KIAA1272 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] ENQDTGFKFLFTLFR;IPYMAARVVFIKWIVTFFLEK;KVVQVYR;LICAMMTRR;RMIMELTMNKK;TVYGVEMTNLPLDKLSEQKEK;VVFIKWIVTFFLEKK 7 4.5 0.97934 -2.0449 11.6763 11.6537 7.60977 3.8672 10.5811 0 0 0 0 6.98755 11.6309 0 Q2PZI1 D19L1_HUMAN Protein C-mannosyl-transferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1) DPY19L1 GA0500 KIAA0877 Homo sapiens (Human) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] mannosyltransferase activity [GO:0000030] TLLLPVVLVVFVAIVRK;YTKTLLLPVVLVVFVAIVR 2 3 0.37844 0.22043 0 0 0 0 0 0 0 4.96666 0 0 7.52341 0 Q2Q1W2 LIN41_HUMAN E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) TRIM71 LIN41 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] P-body [GO:0000932] miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CLDCQEHLCDNCVRAHQR;LRQNLNK;LTKDHYIER;NGRAGAPAGAGGHSNHR 4 5.9 0.93597 -0.5459 0 0 0 6.15496 0 6.46979 0 0 0 0 11.1971 0 Q2QD12 RPEL1_HUMAN Ribulose-phosphate 3-epimerase-like protein 1 (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase-like protein 1) RPEL1 Homo sapiens (Human) "carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]" cytosol [GO:0005829] D-ribulose-phosphate 3-epimerase activity [GO:0004750]; metal ion binding [GO:0046872] NICSEAAQKR 1 4.4 0.92877 -0.46427 0 0 0 0 0 0 0 0 0 0 11.37 0 Q2QL34 MP17L_HUMAN Mpv17-like protein (M-LP homolog) (M-LPH) MPV17L Homo sapiens (Human) negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] AGWWPALSR 1 4.6 0.91636 -0.41602 0 0 0 0 0 0 0 0 0 0 9.89067 0 Q2T9J0 TYSD1_HUMAN "Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]" TYSND1 Homo sapiens (Human) protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of fatty acid beta-oxidation [GO:0031998] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252] DDEVSEDEEADQLR 1 2.5 0.89763 -0.23544 0 0 0 0 0 0 0 6.5432 0 0 0 0 Q2T9L4 INSY1_HUMAN Inhibitory synaptic factor 1 (InSyn1) INSYN1 C15orf59 Homo sapiens (Human) inhibitory postsynaptic potential [GO:0060080]; postsynaptic specialization organization [GO:0099084] GABA-ergic synapse [GO:0098982]; postsynaptic density [GO:0014069] QRMKMVIGQLEGILR 1 5.1 0.44982 0.19153 0 0 0 0 0 0 0 6.17594 0 0 0 0 Q2TAA2 IAH1_HUMAN Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-) IAH1 Homo sapiens (Human) lipid catabolic process [GO:0016042] "hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]" QHIPLEEYAANLK 1 5.2 0.87533 -0.12816 0 0 0 0 0 0 0 0 0 0 0 10.7688 Q2TAA8 TXIP1_HUMAN Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1) TSNAXIP1 TXI1 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] VGPREPEPAS 1 1.5 0.98056 -1.6213 0 0 0 9.65628 0 0 0 0 0 0 0 0 Q2TAC2 CCD57_HUMAN Coiled-coil domain-containing protein 57 CCDC57 Homo sapiens (Human) centriole replication [GO:0007099]; cilium assembly [GO:0060271]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule nucleation [GO:0007020]; positive regulation of mitotic cell cycle [GO:0045931] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle microtubule [GO:0005876] AEVSELK;DLELERYDAAFAQAR;ELKVKLLHK;LDALQGPK;LELERVHSDK;SLERDQVQLGLDWQRR;YDAAFAQAR 7 7.1 0.97487 -3.454 0 0 0 0 9.28466 0 0 0 10.0197 0 0 8.65625 Q2TAC6 KIF19_HUMAN Kinesin-like protein KIF19 KIF19 Homo sapiens (Human) axonemal microtubule depolymerization [GO:0060404]; microtubule-based movement [GO:0007018]; plus-end specific microtubule depolymerization [GO:0070462] axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] ALGTEGR;ASQTQNR;EESLEAKRR;HLGKVTLPLAKVK;LALEQRCR;NTLTYAGR;RRLLELENR;SLCDEIIQGQR;VDEQMVVLMDPMEDPDDILRAHRSR 9 9.7 0.97608 -5.2944 10.0285 0 0 0 0 0 11.425 0 11.5562 13.3752 9.72293 8.73457 Q2TAK8 PWP3A_HUMAN PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) PWWP3A EXPAND1 MUM1 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleosome binding [GO:0031491] CFPASVGHHLCDLCGGR 1 2.3 0.65352 0.17017 0 0 0 0 0 0 0 6.42782 0 0 0 0 Q2TAL5 SMTL2_HUMAN Smoothelin-like protein 2 SMTNL2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036] filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815] MEPAPDAQEARTVR 1 3 0.92225 -0.44279 0 0 6.42843 0 0 0 0 0 0 0 0 6.87738 Q2TAL6 VWC2_HUMAN Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2) VWC2 UNQ739/PRO1434 Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] AMPA glutamate receptor complex [GO:0032281]; basement membrane [GO:0005604]; extracellular space [GO:0005615]; extrinsic component of postsynaptic membrane [GO:0098890]; glutamatergic synapse [GO:0098978]; interstitial matrix [GO:0005614] TDECTICHCTYEEGTWRIER 1 6.2 0.91801 -0.43484 5.71666 0 0 0 0 0 0 0 0 0 0 0 Q2TAL8 QRIC1_HUMAN Transcriptional regulator QRICH1 (Glutamine-rich protein 1) QRICH1 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] EFLDSLASK;NAELEKDAQNR;NWAQTKNAELEKDAQNR 3 3.4 0.98127 -1.5907 0 0 0 0 0 0 0 0 0 0 0 7.31388 Q2TAM9 TUSC1_HUMAN Tumor suppressor candidate gene 1 protein (TSG-9) (TSG9) TUSC1 Homo sapiens (Human) DSGREDEPGSPR 1 5.7 0.92438 -0.45033 0 0 0 4.35396 0 0 0 0 0 0 0 0 Q2TAP0 GOG7B_HUMAN Golgin subfamily A member 7B GOLGA7B C10orf132 C10orf133 Homo sapiens (Human) protein targeting to membrane [GO:0006612] Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178]; plasma membrane [GO:0005886] enzyme binding [GO:0019899] VIEISIYEDR 1 6 0.7947 0.01603 0 0 0 0 0 7.50589 0 0 0 0 0 0 Q2TAY7 SMU1_HUMAN "WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]" SMU1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] TLTVHEK 1 1.4 0.90936 -0.30979 0 0 0 0 0 0 0 8.38154 0 0 0 0 Q2TAZ0 ATG2A_HUMAN Autophagy-related protein 2 homolog A ATG2A KIAA0404 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495] FLYLHTSERMPR;FTSEVPIWLDYHGK;GASGRKGQGR;GVAVEVR;ITALCETK;ITALCETKDEGGK;LSAPRATLR 7 3.4 0.97518 -3.1836 0 0 0 8.71256 0 7.56575 0 9.25529 0 9.25633 8.74749 0 Q2TAZ0 ATG2A_HUMAN Autophagy-related protein 2 homolog A ATG2A KIAA0404 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495] LCERAGLPLLAAPLLRSLLPR 1 6.3 0.531 0.18665 0 0 0 0 0 0 0 0 0 8.18646 0 0 Q2TB10 ZN800_HUMAN Zinc finger protein 800 ZNF800 PP902 Homo sapiens (Human) acinar cell differentiation [GO:0090425]; endocrine pancreas development [GO:0031018] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] ITASLEIRAIKKPIDFVLNK;STSPSAAGGQQK;VTKNFSLHR 3 6.2 0.97081 -1.3401 0 0 0 0 0 0 0 0 6.82235 9.45014 0 0 Q2TB18 ASTE1_HUMAN Single-strand DNA endonuclease ASTE1 (EC 3.1.-.-) (Protein asteroid homolog 1) ASTE1 HT001 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303] 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] DRENVKELLCCSMEEYQQSQVK;ENVKELLCCSMEEYQQSQVK;VCFVQCFSEADR 3 5 0.96542 -1.1567 0 0 0 0 8.36925 8.77735 8.49434 0 0 0 0 0 Q2TB90 HKDC1_HUMAN Hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) HKDC1 Homo sapiens (Human) glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340] AELEYGLK;ATDCEGEDVVDMLR;FAVHLMAFYFSK;KLPLGLTFSFPCRQTK;MISGLYLGELVRLILLK 5 7.3 0.97801 -1.5258 17.2714 17.2999 17.1745 14.0732 0 13.6316 15.1463 14.8992 14.5578 17.5981 17.4942 12.2767 Q2TBA0 KLH40_HUMAN Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin) KLHL40 KBTBD5 SRYP Homo sapiens (Human) negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528] A band [GO:0031672]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; I band [GO:0031674] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EADKGTSK;FQIPSIFTICVSFLQKR;GKDGAGAK;LSFKWGHRHR 4 9.1 0.97993 -1.5592 0 0 0 7.83788 0 0 0 0 0 0 0 11.9295 Q2TBC4 PRIC4_HUMAN Prickle-like protein 4 (Overexpressed breast tumor protein) PRICKLE4 C6orf49 OEBT Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]; zinc ion binding [GO:0008270] LEGHTCEK;TLLAAAGGSSLQTQR 2 6.7 0.96481 -1.1517 0 0 0 0 0 7.86567 0 0 0 0 0 0 Q2TBE0 C19L2_HUMAN CWF19-like protein 2 CWF19L2 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014] EDYRRER;EKSQDEVLRDDPPK;FESAKSIEER;KAIMESDEEWSMNKK;KIEQEKNQALEQSK;LFMRMASKFMGK;LTSWSRSDGR 7 9.2 0.9782 -6.6161 0 0 0 10.0347 0 10.4494 0 10.0308 0 0 0 0 Q2TBF2 WSCD2_HUMAN Sialate:O-sulfotransferase 2 (WSC domain-containing protein 2) WSCD2 KIAA0789 Homo sapiens (Human) Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] ALMAEFNR;LEYDPYTADMQK;LQLAQESARR;VLVVHFEDLK 4 7.1 0.97864 -2.0913 0 0 10.2036 0 0 0 0 0 0 0 14.5802 0 Q2UY09 COSA1_HUMAN Collagen alpha-1(XXVIII) chain COL28A1 COL28 Homo sapiens (Human) cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199] basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] EKLTEVVK;GEAGERGPGGIPGYK;GLPGEGFPGPK;GPGGIPGYKGDKGER;GPPGPSGPR 5 4.4 0.97998 -2.0108 0 0 0 0 0 0 7.65935 9.25477 7.17503 0 0 10.2445 Q2V2M9 FHOD3_HUMAN FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) cardiac myofibril assembly [GO:0055003]; cortical actin cytoskeleton organization [GO:0030866]; sarcomere organization [GO:0045214] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018] actin filament binding [GO:0051015] IVHRRIINR;KHSIILRTQLSVR;SNAINIGLTVLPPPR;SPDDEEKGDGEAGR;VDVGCLDNRGSVK 5 4.5 0.96376 -1.1813 0 10.6279 3.47418 0 0 0 0 8.95134 0 7.12712 0 0 Q2VIQ3 KIF4B_HUMAN Chromosome-associated kinesin KIF4B (Chromokinesin-B) KIF4B Homo sapiens (Human) microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AQINIREDPKEGIK;ELQTAKKNVNQAK;GLLCLGNVISALGDDK;IHVTKLENSLR;LLQELEGQIADLKK;QSSVLRRK;VQLMRQMK;VSYLEIYNEEILDLLCPSREK;YCSEHSVNEHEDGDGDGDSDEGDDEEWKPTK 9 11 0.97317 -2.5876 0 0 0 7.11718 10.6798 0 7.44402 0 0 7.58939 8.4643 11.9073 Q2VPJ9 LR75B_HUMAN Leucine-rich repeat-containing protein 75B (Leucine-rich repeat-containing protein FAM211B) LRRC75B C22orf36 FAM211B Homo sapiens (Human) AGPEAGSEAGAAAGCGPAPYERR;EIQSTLRERRPER 2 23.7 0.9638 -1.2005 0 0 7.43438 0 0 0 0 0 0 0 0 0 Q2VWA4 SKOR2_HUMAN SKI family transcriptional corepressor 2 (Functional Smad-suppressing element on chromosome 18) (Fussel-18) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein) SKOR2 CORL2 FUSSEL18 Homo sapiens (Human) cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuroblast proliferation [GO:1902692]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]" AGLSGLFWPAGR;APAVAGAFPLGLNSSR;EEMVQQLQIIPYAASLIRKEK;KDVENMGKEELQK;LGAHLSK 5 6.8 0.95505 -0.94494 0 6.36017 0 9.61912 10.8273 9.45191 0 9.66363 9.61811 0 0 0 Q2VYF4 LETM2_HUMAN "LETM1 domain-containing protein LETM2, mitochondrial (LETM1 and EF-hand domain-containing protein 2) (Leucine zipper-EF-hand-containing transmembrane protein 1-like)" LETM2 Homo sapiens (Human) mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ribosome binding [GO:0043022]; transmembrane transporter activity [GO:0022857] LELAKFLQETMTEMAR;LLELQTFGTNNLLR;SQMTAQNSKASSK 3 8.8 0.97806 -1.9554 0 0 0 0 0 5.73436 8.87206 0 0 7.44717 0 0 Q2WEN9 CEA16_HUMAN Cell adhesion molecule CEACAM16 (Carcinoembryonic antigen-like 2) (Carcinoembryonic antigen-related cell adhesion molecule 16) (CEA cell adhesion molecule 16) CEACAM16 CEAL2 Homo sapiens (Human) sensory perception of sound [GO:0007605] extracellular space [GO:0005615]; stereocilium tip [GO:0032426] identical protein binding [GO:0042802] SEPINLTVYFGPER;VAILQDSTTR 2 5.6 0.89591 -0.22937 0 11.5108 0 0 0 0 0 0 0 0 0 12.185 Q2WGJ6 KLH38_HUMAN Kelch-like protein 38 KLHL38 C8orfK36 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SIYVLGGMAVSSGR;VFEALMVWIKHDLQARK 2 5.3 0.74474 0.096277 3.86146 0 0 0 9.47822 0 0 0 0 0 0 0 Q2WGJ9 FR1L6_HUMAN Fer-1-like protein 6 FER1L6 C8orfK23 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; response to bacterium [GO:0009617] membrane [GO:0016020] metal ion binding [GO:0046872] EMFPPLCR;GIIQQQK;ISIFQQK;LDGPYFHPGK 4 1.7 0.98063 -2.021 0 0 0 9.1766 0 8.34421 0 0 0 0 10.0091 0 Q2Y0W8 S4A8_HUMAN Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) SLC4A8 KIAA0739 NBC NBC3 NDCBE1 Homo sapiens (Human) basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] "bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; zinc ion binding [GO:0008270]" ALSMNSGNAKEK;EELEGHR;LFGMPAK;LLSSPGK 4 3 0.96472 -1.2204 0 0 0 7.68089 0 0 10.9034 0 0 7.17203 9.47235 0 Q2YD98 UVSSA_HUMAN UV-stimulated scaffold protein A UVSSA KIAA1530 Homo sapiens (Human) protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283] chromosome [GO:0005694]; nucleoplasm [GO:0005654] RNA polymerase II complex binding [GO:0000993] AQADTARAR;FLPAVCSWIQRFTR;QLQKQERPEWQDPELMR 3 5.6 0.97242 -2.7819 0 0 0 0 0 0 0 0 9.93 0 0 0 Q30201 HFE_HUMAN Hereditary hemochromatosis protein (HLA-H) HFE HLAH Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]" apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] AWPTKLEWER;AWPTKLEWERHK 2 3.4 0.95383 -0.77924 0 0 0 6.54902 0 0 0 0 0 0 0 0 Q30201 HFE_HUMAN Hereditary hemochromatosis protein (HLA-H) HFE HLAH Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]" apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] GPRARPALLLLMLLQTAVLQGRLLLPPLVK 1 17.9 0.68498 0.16282 0 0 0 0 0 0 0 0 0 0 4.03975 0 Q30201 HFE_HUMAN Hereditary hemochromatosis protein (HLA-H) HFE HLAH Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]" apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] VPPLVKVTHHVTSSVTTLR 1 7.4 0.94152 -0.61185 0 0 0 8.75656 8.26397 0 11.3363 11.03 0 0 0 0 Q309B1 TR16L_HUMAN Tripartite motif-containing protein 16-like protein (Tripartite motif-containing protein 70) TRIM16L TRIM70 Homo sapiens (Human) cytoplasm [GO:0005737] GIDQKGEER 1 2.6 0.90317 -0.26308 0 9.15135 0 0 0 0 0 0 0 0 0 0 Q30KQ5 DB115_HUMAN "Beta-defensin 115 (Beta-defensin 15) (DEFB-15) (Defensin, beta 115)" DEFB115 DEFB15 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular region [GO:0005576] EKCGEKHICCVPK 1 14.8 0.96119 -1.0632 0 0 0 0 0 0 11.7301 0 0 0 0 0 Q30KQ9 DB110_HUMAN "Beta-defensin 110 (Beta-defensin 10) (DEFB-10) (Beta-defensin 11) (DEFB-11) (Beta-defensin 111) (Defensin, beta 110) (Defensin, beta 111)" DEFB110 DEFB10 DEFB11 DEFB111 Homo sapiens (Human) cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular space [GO:0005615] CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056] KIQLFFFILHFWVTILPAKK 1 29.9 0.85172 -0.079704 0 0 0 0 0 0 0 5.57604 0 0 0 0 Q30KR1 DB109_HUMAN "Putative beta-defensin 109B (Defensin, beta 109, pseudogene 1B) (Defensin, beta 109B)" DEFB109B DEFB109P1B Homo sapiens (Human) cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742] extracellular space [GO:0005615] CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056] AWWILMPIPTPLIMSDYQEPLKPNLK;RLHLLLLILLLFSILLSPVR 2 52.9 0.079491 0.39715 9.21395 0 9.74105 7.08863 0 7.09297 0 0 0 0 0 0 Q32M45 ANO4_HUMAN Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Homo sapiens (Human) calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] AVIAYDWDLIDWEEEEEEIRPQFEAKYSK;LHAPWEVLGR;VFHPVAK;VVTVSTFAAFK 4 6.2 0.81288 -0.01588 0 0 0 0 0 0 7.29554 9.64416 0 9.91821 11.8438 0 Q32M78 ZN699_HUMAN Zinc finger protein 699 (Hangover homolog) ZNF699 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSCPSSFRRHVR;ECGKAFHFLACFKK;SHTGSKPYQCKECGK 3 5.9 0.98099 -1.7453 0 0 0 0 0 0 0 0 0 13.9688 11.3984 0 Q32M84 BTBDG_HUMAN BTB/POZ domain-containing protein 16 BTBD16 C10orf87 Homo sapiens (Human) HTDLESPSAVYEHNHVSLR;NPDRLCISQIQKFFFENFK;SFPENCCFLDR 3 9.7 0.039568 0.51818 0 0 8.56476 7.8308 0 0 0 0 0 0 4.7419 0 Q32MH5 ATOSA_HUMAN Atos homolog protein A ATOSA FAM214A KIAA1370 Homo sapiens (Human) nucleus [GO:0005634] DCLSTCEQPK;DESSVSISHTK;LAQCRQAR;NTEVLRTTLKHSNVWR;QSNYPVLTCSIHTNIGLYEKRIQQHK;QTWTMAPESVLHAK;VPPSGTIQVTLFNPNKTVVK;YLIHLRFQSSK 8 10.8 0.97413 -2.9951 7.35905 8.14858 8.50565 7.4559 5.40272 0 10.9594 10.0037 10.6727 6.36627 7.15775 0 Q32MK0 MYLK3_HUMAN Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) MYLK3 MLCK Homo sapiens (Human) cardiac myofibril assembly [GO:0055003]; cellular response to interleukin-1 [GO:0071347]; positive regulation of membrane permeability [GO:1905710]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of tight junction disassembly [GO:1905075]; protein phosphorylation [GO:0006468]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain kinase activity [GO:0004687] LNMLNEK;VADFLMQGR 2 2 0.93696 -0.55422 15.007 0 14.8941 0 9.853 0 0 0 0 0 0 11.7971 Q32MQ0 ZN750_HUMAN Zinc finger protein 750 ZNF750 Homo sapiens (Human) cell differentiation [GO:0030154]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; membrane biogenesis [GO:0044091]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDIKENLELQARGTHR;LNPSDPNRK 2 3.5 0.88176 -0.16752 12.1429 0 0 0 0 0 0 0 0 0 10.7313 0 Q32MZ4 LRRF1_HUMAN Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) LRRFIP1 GCF2 TRIP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEMLEEIRQLQQK;EFFDSVR;EIYQVQK;LESQVSR 4 5.3 0.98056 -1.6364 0 0 3.96625 0 9.20823 0 0 7.56628 0 5.41221 10.4831 0 Q32NC0 CR021_HUMAN UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) C18orf21 XTP13 PNAS-124 PNAS-131 Homo sapiens (Human) NTSKTKK;QKHYLEAAARGLHDSCPGQAR 2 12.7 0.98064 -1.6222 0 0 0 0 0 0 0 0 0 10.1517 0 0 Q32P28 P3H1_HUMAN Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) P3H1 GROS1 LEPRE1 PSEC0109 Homo sapiens (Human) bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of post-translational protein modification [GO:1901874]; positive regulation of neuron projection development [GO:0010976]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of protein secretion [GO:0050708] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] ALKLGQEGK;ESLDVSRLTR;RCLGPPAAHSLSEEMELEFR;TVTAEVQPQCGR 4 6.9 0.96517 -1.248 0 0 6.37626 11.0156 0 0 0 0 0 0 7.62556 0 Q32P44 EMAL3_HUMAN Echinoderm microtubule-associated protein-like 3 (EMAP-3) EML3 Homo sapiens (Human) cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of mitotic spindle assembly [GO:1901673] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] VLGAGGAGPAPATPSR 1 1.8 0.84689 -0.063736 0 0 0 0 9.98726 0 0 0 0 0 0 0 Q32P44 EMAL3_HUMAN Echinoderm microtubule-associated protein-like 3 (EMAP-3) EML3 Homo sapiens (Human) cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic metaphase chromosome alignment [GO:0007080]; regulation of mitotic spindle assembly [GO:1901673] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] MELVKAALAEALRLLR 1 8.2 0.84986 -0.076074 0 0 0 0 4.69321 0 0 0 0 0 0 0 Q330K2 NDUF6_HUMAN "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (Putative phytoene synthase)" NDUFAF6 C8orf38 Homo sapiens (Human) biosynthetic process [GO:0009058]; mitochondrial respiratory chain complex I assembly [GO:0032981] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] AFPAFLQTVSLEDFLKK;NTLLPLYLYIQSWRK 2 9.6 0.73098 0.11353 0 0 0 5.20167 0 0 0 0 0 3.41115 0 17.6073 Q38SD2 LRRK1_HUMAN Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) LRRK1 KIAA1790 Homo sapiens (Human) bone resorption [GO:0045453]; intracellular signal transduction [GO:0035556]; osteoclast development [GO:0036035]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AMLSYLRAQLR;LEACTRK;LFLENSK;LLEIDISSNK;SLNSLNVSR 5 2.2 0.97832 -2.1281 0 0 11.2917 8.73139 0 0 0 11.1372 11.7101 0 7.93923 11.0804 Q3B7T1 EDRF1_HUMAN Erythroid differentiation-related factor 1 EDRF1 C10orf137 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] AYYVLSDAAMSLQK;EFSPEEGLYYNK;LIDQKWQRK;REFSPEEGLYYNK;SKEHWYQK;TLLLDELDIQELFMR;VIKDIAQNILSFLK 7 5.9 0.95502 -0.80581 2.75651 0 0 0 0 9.35021 0 0 7.56552 5.64458 9.92147 9.6894 Q3B7T3 BEAN1_HUMAN Protein BEAN1 (Brain-expressed protein associating with Nedd4 homolog) (BEAN) BEAN1 Homo sapiens (Human) membrane [GO:0016020] LQRHRHR 1 2.7 0.82982 -0.025469 0 0 0 0 13.2842 0 0 0 0 9.1014 0 0 Q3B820 F161A_HUMAN Protein FAM161A FAM161A Homo sapiens (Human) cilium assembly [GO:0060271]; cilium organization [GO:0044782]; positive regulation of protein acetylation [GO:1901985]; visual perception [GO:0007601] astral microtubule [GO:0000235]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; spindle microtubule [GO:0005876] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] EYQRELEEREEK;LLTTRAKAYDSHQSLAQISK;VLEYFNNQETKSVTEDK 3 6.8 0.98055 -1.6086 0 0 0 9.82091 0 0 0 3.89394 0 7.52011 0 0 Q3B8N5 PROX2_HUMAN Prospero homeobox protein 2 (Homeobox prospero-like protein PROX2) (PROX-2) PROX2 Homo sapiens (Human) cell development [GO:0048468]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AKLMFFFTR;VREQLHLLKQQLR 2 3.7 0.95454 -0.95261 0 9.00054 0 0 0 0 0 0 0 0 0 0 Q3BBV0 NBPF1_HUMAN NBPF family member NBPF1 (Neuroblastoma breakpoint family member 1) NBPF1 KIAA1693 Homo sapiens (Human) cytoplasm [GO:0005737] EDQEATGPR;LSPENDNDDDEDVQVEVAEK;NINITFEEDK 3 4 0.91457 -0.33523 0 0 0 0 0 0 0 0 0 0 8.32378 0 Q3C1V8 BSH_HUMAN Brain-specific homeobox protein homolog BSX BSX1 Homo sapiens (Human) cell differentiation [GO:0030154]; eating behavior [GO:0042755]; locomotory behavior [GO:0007626]; mammary gland involution [GO:0060056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TVFSDSQLSGLEKR 1 6 0.65294 0.17002 0 0 0 0 10.0044 0 0 0 0 0 0 0 Q3C1V9 YK041_HUMAN Putative uncharacterized protein ENSP00000334305 Homo sapiens (Human) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] external side of plasma membrane [GO:0009897] DAKPAVSGCQEESWLQSEYDEMHPR;GVESVLEK;TLNQVHR 3 5.2 0.94361 -0.62724 0 13.2362 0 0 0 0 0 0 9.66583 0 0 6.94087 Q3I5F7 ACOT6_HUMAN Acyl-coenzyme A thioesterase 6 (Acyl-CoA thioesterase 6) (EC 3.1.2.-) ACOT6 C14orf42 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617] GGDLCLSMASFLK;LLCLAQNK 2 5 0.91575 -0.37527 0 0 0 0 0 9.28529 10.3062 0 0 0 0 0 Q3KNS1 PTHD3_HUMAN Patched domain-containing protein 3 (Patched-related protein) PTCHD3 PTR Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] EVVCLCWLKKADPK 1 1.5 0.85938 -0.081907 0 10.4651 0 0 0 0 0 0 0 0 0 0 Q3KNV8 PCGF3_HUMAN Polycomb group RING finger protein 3 (RING finger protein 3A) PCGF3 RNF3 RNF3A Homo sapiens (Human) random inactivation of X chromosome [GO:0060816]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805] histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872] LNLSSFNELDILCNEEILGKDHTLKFVVVTR 1 12.8 0.87106 -0.10178 10.9447 0 0 0 0 0 0 0 0 0 0 0 Q3KNW5 SOAT_HUMAN Sodium-dependent organic anion transporter (SOAT) (Solute carrier family 10 member 6) (SLC10A6) SLC10A6 SOAT Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; sodium-dependent organic anion transport [GO:0043251]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] bile acid:sodium symporter activity [GO:0008508]; sodium-dependent organic anion transmembrane transporter activity [GO:0043250] IILKIGAVVGGVLLLVVAVAGVVLAK;KNSGCTEVCHTR;QSKIILKIGAVVGGVLLLVVAVAGVVLAK 3 10.9 0.25163 0.2797 5.91059 6.34309 0 0 0 6.83807 0 6.19034 0 0 4.75995 0 Q3KP22 MAJIN_HUMAN Membrane-anchored junction protein MAJIN C11orf85 Homo sapiens (Human) double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283] "chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]" DNA binding [GO:0003677] LWPLISLMSR 1 4.6 0.93646 -0.55224 0 0 0 0 0 6.0072 0 0 0 11.1178 0 0 Q3KP31 ZN791_HUMAN Zinc finger protein 791 ZNF791 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" RNHTGEKPYECKECAK 1 2.8 0.85051 -0.076074 0 0 0 0 0 0 5.21378 0 0 0 0 0 Q3KP44 ANR55_HUMAN Ankyrin repeat domain-containing protein 55 ANKRD55 Homo sapiens (Human) AECVQSLLELGMDSNLR;EEQRAHQKDPSR;LLLKMGANINMQDAYGR 3 7.5 0.95554 -0.8587 0 0 0 0 0 0 0 5.20109 9.54154 0 0 0 Q3KP66 INAVA_HUMAN Innate immunity activator protein INAVA C1orf106 Homo sapiens (Human) adherens junction maintenance [GO:0034334]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; reactive oxygen species biosynthetic process [GO:1903409]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ALEARLEACLEELR;DSPAGRGLSK;THRHRGAWVPAGSR 3 5.7 0.9806 -1.6296 0 0 0 0 9.34997 0 11.9873 0 0 0 0 10.0294 Q3KQU3 MA7D1_HUMAN MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819] EEAERQR;EEQLAREAEAR;LEEQRLK 3 3 0.97655 -1.4893 0 0 6.96394 0 0 0 0 7.21228 0 0 9.63379 0 Q3KQV3 ZN792_HUMAN Zinc finger protein 792 ZNF792 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVHPSTHPGEVP;SAHECSECGK;SSDLMKHQR 3 4.9 0.98102 -1.7516 0 0 0 0 0 0 9.22002 0 10.2639 0 0 3.80653 Q3KR16 PKHG6_HUMAN Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) PLEKHG6 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056] cell junction [GO:0030054]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; microvillus [GO:0005902]; spindle pole [GO:0000922] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DPRLTFSTLELR;LTRAQLQR;LVCQPLR;QLLLEGPVRVKEGR;QMLCDLLIKPHQRITKYPLLLHAVLK;THRSFWDEVLGPTLEETR 6 10.8 0.98049 -1.6709 0 0 0 9.8237 10.5123 9.23984 11.6804 0 0 7.98965 0 7.49442 Q3KR37 ASTRB_HUMAN Protein Aster-B (GRAM domain-containing protein 1B) GRAMD1B KIAA1201 UNQ3032/PRO9834 Homo sapiens (Human) cellular response to cholesterol [GO:0071397]; cholesterol homeostasis [GO:0042632]; intracellular sterol transport [GO:0032366] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786] HLESELAKTESTYLAEMHRQSPK;TYMMMFR;YHDTELQK 3 5.1 0.97654 -2.1826 0 0 0 0 0 0 9.70518 0 0 10.8367 0 9.10179 Q3KR37 ASTRB_HUMAN Protein Aster-B (GRAM domain-containing protein 1B) GRAMD1B KIAA1201 UNQ3032/PRO9834 Homo sapiens (Human) cellular response to cholesterol [GO:0071397]; cholesterol homeostasis [GO:0042632]; intracellular sterol transport [GO:0032366] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786] HLESELAKTESTYLAEMHRQSPK;VLSIPLLTVLILAR;YHDTELQK 3 10.6 0.89731 -0.23552 0 0 0 0 1.75005 0 0 0 0 0 0 0 Q3KRA6 CB076_HUMAN UPF0538 protein C2orf76 C2orf76 Homo sapiens (Human) IIHQAHKSK;SFEHRNFKPVVYHGVNLDQTVK 2 24.6 0.98061 -2.0156 7.7241 0 0 0 8.24883 0 14.1863 9.18249 0 0 0 0 Q3KRA9 ALKB6_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 6) ALKBH6 ABH6 Homo sapiens (Human) cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] VPRVLRAGLLLGK;WTQLSGRKLQNWGGLPHPR 2 13.4 0.88252 -0.17884 3.41454 0 0 0 0 0 0 10.6889 0 0 0 0 Q3L8U1 CHD9_HUMAN Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) CHD9 KIAA0308 KISH2 PRIC320 AD-013 x0008 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ADASSGSDSTSSSSEDSDSSNED;CVIIDEAHR;EQALRHPQLFERLK;IGKLIITLGKK;LDRPPSNIWK;LQAILKPMMLRR;LVTRNSYEREMFDR;RQLNEHDVEIICR;TECFRVEK;VLEVSFCEDK 10 4.3 0.97446 -3.4705 0 9.06164 4.7094 0 6.47955 9.17095 9.89875 0 7.70176 9.22774 6.29919 0 Q3LHN2 KR192_HUMAN Keratin-associated protein 19-2 KRTAP19-2 KAP19.2 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] CYGYGCGCGSFCR;GCGDGCCCPSCYR;GCGDGCCCPSCYRR;GCGDGCCCPSCYRRYR;MCYGYGCGCGSFCRLGYGCGYEGCRYGCGHR;YGCGHRGCGDGCCCPSCYRR 6 90.4 0.9514 -0.68881 0 9.84566 0 9.02909 10.3148 9.19131 9.7536 9.65682 0 3.17445 5.7689 7.39326 Q3LI60 KR203_HUMAN Keratin-associated protein 20-3 KRTAP20-3 KAP20.3 Homo sapiens (Human) intermediate filament [GO:0005882] YSYTSGFGAFRILDCGYR 1 40.9 0.91968 -0.43793 0 9.05197 0 0 0 0 0 0 0 0 0 0 Q3LI62 KR204_HUMAN Putative keratin-associated protein 20-4 KRTAP20-4 KAP20.4 Homo sapiens (Human) intermediate filament [GO:0005882] MSYYSHLSGGLGCGLAVAVTMGR 1 52.3 0.70235 0.16126 0 0 0 0 0 0 7.75007 0 0 0 0 0 Q3LI66 KRA62_HUMAN Keratin-associated protein 6-2 KRTAP6-2 KAP6.2 Homo sapiens (Human) keratinization [GO:0031424] cytosol [GO:0005829]; intermediate filament [GO:0005882] identical protein binding [GO:0042802] CGYSSCCGYGHGYGSR 1 25.8 0.6415 0.17209 0 3.05613 0 0 0 0 0 0 0 0 8.9963 0 Q3LI67 KRA63_HUMAN Keratin-associated protein 6-3 KRTAP6-3 KAP6.3 Homo sapiens (Human) keratinization [GO:0031424] cytosol [GO:0005829]; intermediate filament [GO:0005882] GLDCGYGCGYGYVSHSFCGCGYR 1 20.9 0.70272 0.16126 9.34917 0 0 0 0 0 0 0 0 0 0 0 Q3LI76 KR151_HUMAN Keratin-associated protein 15-1 KRTAP15-1 KAP15.1 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] MSYNCSSGNFSSCCFGSYLR;SYNCSSGNFSSCCFGSYLR 2 14.6 0.94807 -0.66373 0 0 5.90749 0 0 0 0 0 0 0 0 0 Q3LXA3 TKFC_HUMAN Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] TKFC DAK Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354] AVKSAEAAAEATK 1 2.3 0.88675 -0.18488 0 0 0 0 8.69777 0 0 0 0 0 0 0 Q3MII6 TBC25_HUMAN TBC1 domain family member 25 TBC1D25 OATL1 Homo sapiens (Human) autophagy [GO:0006914]; regulation of autophagosome maturation [GO:1901096] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410] GTPase activator activity [GO:0005096] RLGHNQPQR 1 9 0.92123 -0.44031 0 0 0 0 0 0 0 0 0 10.733 0 0 Q3MIN7 RGL3_HUMAN Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) RGL3 Homo sapiens (Human) Ras protein signal transduction [GO:0007265] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] VLLIPDNANVFYAMSPVAPR 1 2.8 0.60916 0.17595 0 0 0 0 0 0 0 7.27696 0 0 0 0 Q3MIP1 IPIL2_HUMAN "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2" ITPRIPL2 Homo sapiens (Human) membrane [GO:0016020] ILSSYVLKTVLLAVLLR;SQRTQGFLEGEP 2 5.4 0.88683 -0.18584 0 0 0 0 0 6.65191 0 0 0 0 0 9.39234 Q3MIS6 ZN528_HUMAN Zinc finger protein 528 ZNF528 KIAA1827 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CHECDKVFR;LAQHQRIHTGEKPYKCHECDK;TLYRDVMLENYR 3 6.7 0.94149 -0.61409 3.87784 0 0 0 8.74285 0 0 0 0 0 0 0 Q3MIT2 PUS10_HUMAN tRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) PUS10 CCDC139 DOBI Homo sapiens (Human) primary miRNA processing [GO:0031053]; tRNA pseudouridine synthesis [GO:0031119] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(55) synthase activity [GO:0160148] EGEEEKTK;ISVSHVGSTASK;QSLSLGRDDIVQLK 3 6.4 0.97644 -2.1958 0 0 0 0 10.6634 0 0 0 0 8.70331 0 11.3599 Q3MIW9 MUCL3_HUMAN Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) MUCL3 C6orf37 DPCR1 PBLT Homo sapiens (Human) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] DPMIRNQR;ITAASKTTYK;TSTSSHK 3 4.8 0.97951 -1.9979 0 0 0 0 0 0 10.2258 0 0 0 12.0428 0 Q3MIW9 MUCL3_HUMAN Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) MUCL3 C6orf37 DPCR1 PBLT Homo sapiens (Human) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] TTSTTEK 1 3 0.91065 -0.32604 0 0 0 0 0 0 7.80587 0 0 0 0 0 Q3MIX3 ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) ADCK5 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] protein serine/threonine kinase activity [GO:0004674] LGQLWGSHLLSR;LVEVMHPSFGFSWVLQDLK;QKPWPSPAVFFRRNVR;VLEDRALK 4 9.5 0.96516 -1.2153 0 11.775 0 0 0 0 0 11.3841 0 0 0 9.10502 Q3MJ13 WDR72_HUMAN WD repeat-containing protein 72 WDR72 Homo sapiens (Human) ameloblast differentiation [GO:0036305]; enamel mineralization [GO:0070166]; endocytosis [GO:0006897]; extracellular matrix disassembly [GO:0022617]; gene expression [GO:0010467]; microtubule polymerization [GO:0046785]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein import [GO:0017038]; protein localization to plasma membrane [GO:0072659]; regulation of pH [GO:0006885]; ruffle organization [GO:0031529]; tubulin complex assembly [GO:0007021]; vesicle organization [GO:0016050] cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634] GAGNDILNMSSFYSCLR 1 1.5 0.78425 0.024672 0 0 0 5.55888 0 0 0 0 0 0 0 0 Q3MJ16 PA24E_HUMAN Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE) PLA2G4E Homo sapiens (Human) glycerophospholipid catabolic process [GO:0046475]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; positive regulation of endocytic recycling [GO:2001137] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; N-acyltransferase activity [GO:0016410]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A1 activity [GO:0008970]" DLLVMVNESFENTQR 1 1.7 0.78384 0.026882 0 0 0 0 9.41246 0 0 0 0 0 0 0 Q3SX64 CMA1D_HUMAN Protein CIMAP1D (CIMAP1 family member D) (Outer dense fiber protein 3-like protein 2) CIMAP1D C19orf19 ODF3L2 Homo sapiens (Human) cytoplasmic microtubule [GO:0005881]; cytoskeleton [GO:0005856] VTEGQIPETGLR 1 4.2 0.9347 -0.53042 0 0 0 0 0 0 12.1704 0 0 0 0 0 Q3SXM5 HSDL1_HUMAN Inactive hydroxysteroid dehydrogenase-like protein 1 (Short chain dehydrogenase/reductase family 12C member 3) HSDL1 SDR12C3 Homo sapiens (Human) intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] SITVICDFYSLIRLHFIPR 1 5.8 0.94236 -0.61566 0 12.5994 0 0 0 0 0 0 0 0 0 0 Q3SXY7 LRIT3_HUMAN "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3" LRIT3 Homo sapiens (Human) gene expression [GO:0010467]; protein localization [GO:0008104]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; response to light stimulus [GO:0009416]; synapse assembly involved in innervation [GO:0060386]; synaptic signaling [GO:0099536]; visual perception [GO:0007601] cell tip [GO:0051286]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; perikaryon [GO:0043204]; synapse [GO:0045202] LVLCNDMVEPHQEPR;VAKNGSK;VCKLQCK;VEGDDSQWSLLLVVTSTACVVILPLICFLLYK 4 11.3 0.97941 -1.8462 6.78908 6.17327 0 10.0622 0 0 0 7.22738 10.562 0 6.95396 7.58203 Q3SXZ3 ZN718_HUMAN Zinc finger protein 718 ZNF718 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HKRIHAR;QSSHLNK;RIHTGEKPYTCEECGK;VFANLHNHK;VQKGGYNR 5 9.8 0.97837 -1.9243 0 12.1275 0 0 0 7.90887 0 0 6.83504 0 8.9349 0 Q3SXZ7 TTLL9_HUMAN Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9) TTLL9 C20orf125 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; motile cilium [GO:0031514] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" FDLRVYVLVMSYIPLR;FSNTRFTLNSIDDQYVHLTNVAVQK;FTLNSIDDQYVHLTNVAVQK 3 17.8 0.96689 -1.2936 0 0 0 0 7.67108 0 0 0 0 0 0 0 Q3SY00 T10IP_HUMAN Testis-specific protein 10-interacting protein (Tsga10-interacting protein) TSGA10IP Homo sapiens (Human) cilium organization [GO:0044782] cytoskeleton [GO:0005856]; photoreceptor connecting cilium [GO:0032391] ELQGPWDLEK;QVAHCLAAYAPR 2 4 0.9366 -0.54485 0 0 0 0 0 0 10.8092 0 0 4.96185 0 0 Q3SY05 CA157_HUMAN Putative uncharacterized protein encoded by LINC00303 LINC00303 C1orf157 NCRNA00303 Homo sapiens (Human) WPPACCGRR 1 8.7 0.78302 0.030108 0 0 0 0 0 0 0 0 0 0 6.3591 0 Q3SY52 ZIK1_HUMAN Zinc finger protein interacting with ribonucleoprotein K (Zinc finger protein 762) ZIK1 ZNF762 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFRGKYSLVQHQR;RIHTGERPYECSECGKLFR;SLKRDMDR 3 8.2 0.97338 -2.649 7.7494 0 2.9013 0 5.41326 0 0 0 0 13.4295 0 0 Q3SY84 K2C71_HUMAN "Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)" KRT71 K6IRS1 KB34 KRT6IRS1 Homo sapiens (Human) hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] FASFIDK;FASFIDKVR;KDVDAAYANKVELQAK;SGAAAKGGFSGCSAVLSGGSSSSFRAGSK 4 10.3 0.97575 -2.348 0 0 0 0 0 0 0 0 0 10.2315 0 0 Q3SYG4 PTHB1_HUMAN Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) BBS9 PTHB1 Homo sapiens (Human) cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; visual perception [GO:0007601] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; pericentriolar material [GO:0000242] TVSFSVYLK;VIQCKFRLPLK 2 2.3 0.91719 -0.39924 13.9166 0 0 0 0 3.95065 0 0 0 11.079 0 0 Q3T8J9 GON4L_HUMAN GON-4-like protein (GON-4 homolog) GON4L GON4 KIAA1606 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] DCACSCHEGGPDSK;DLAFAQAYLTR;ELFEQLKMK;LTWLASERR;MEPEEAR;MTLRPGPVTQEDRCDHLTLK;QLQEVEK;VSSTGEK 8 3.7 0.97217 -2.69 6.90364 0 5.58568 0 0 0 11.147 0 10.9541 0 8.5694 11.7286 Q3T906 GNPTA_HUMAN N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] GNPTAB GNPTA KIAA1208 Homo sapiens (Human) carbohydrate phosphorylation [GO:0046835]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256]; secretion of lysosomal enzymes [GO:0033299] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] calcium ion binding [GO:0005509]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] ACNNSACDWDGGDCSGNSGGSR;KLQHYTDSYLGFLPWEK;NQAIITDETNDSLVAPQEK;TNVSHVVGQLDDIR 4 5.7 0.87644 -0.13443 0 11.7459 0 4.70393 0 0 10.8203 10.8513 0 0 0 0 Q3V6T2 GRDN_HUMAN Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A APE GRDN KIAA1212 Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; cell migration [GO:0016477]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; lamellipodium assembly [GO:0030032]; maintenance of protein location in plasma membrane [GO:0072660]; membrane organization [GO:0061024]; nervous system development [GO:0007399]; positive regulation of cilium assembly [GO:0045724]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of neuron projection development [GO:0010975]; small GTPase-mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; COPI-coated Golgi to ER transport vesicle [GO:0030142]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886] actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; epidermal growth factor receptor binding [GO:0005154]; G-protein alpha-subunit binding [GO:0001965]; G-protein gamma-subunit binding [GO:0031682]; GDP-dissociation inhibitor activity [GO:0005092]; guanyl-nucleotide exchange factor activity [GO:0005085]; insulin receptor binding [GO:0005158]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activator activity [GO:0043539]; SH2 domain binding [GO:0042169]; vascular endothelial growth factor receptor 2 binding [GO:0043184] AEELENELHHLEKENELLQKK;DIEKENK;ELEHYKEK;ESQETTRELLK;ITCEKIEALEQENSELER;KIQQLESELQDLEMENQTLQKNLEELK;LESEVSR;LLHDEQSTDDRYK;NHETVAAEYK;NLEVEHRDLEDR;QIKFYYQETLQQLIMMSLPNVLIIGK;SAHKNLEVEHRDLEDR;SVSGKTPGDFYDR;TLLEQNMESK;TLLEQNMESKDLFHVEQR;TQQMNNDLEK 16 11.1 0.97681 -4.8711 0 6.75007 10.7534 9.22439 7.44485 9.43425 8.93032 11.4597 9.54224 0 10.5896 7.54404 Q3YBR2 TBRG1_HUMAN Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) TBRG1 NIAM Homo sapiens (Human) DNA replication [GO:0006260]; negative regulation of cell population proliferation [GO:0008285]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726] nucleoplasm [GO:0005654]; nucleus [GO:0005634] AAKATVFENAAICDEIARLEEK;SQNEKYRLK 2 7.5 0.97097 -1.3398 8.44746 0 0 0 0 0 0 0 0 0 0 0 Q3YEC7 RABL6_HUMAN Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) RABL6 C9orf86 PARF Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] GTP binding [GO:0005525] RSSTRPPAEMEPGK;VPTHVPVCVLGNYRDMGEHR 2 4.7 0.90317 -0.26485 0 9.72566 0 0 0 0 0 0 0 0 0 9.37391 Q3ZCN5 OTOGL_HUMAN Otogelin-like protein OTOGL C12orf64 Homo sapiens (Human) inner ear receptor cell stereocilium organization [GO:0060122]; L-arabinose metabolic process [GO:0046373]; protein localization [GO:0008104]; vibrational conductance of sound to the inner ear [GO:0055127] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] alpha-L-arabinofuranosidase activity [GO:0046556] CDVHQVYTPSPSDYGCCGTCK;CYVPESCPCIWK;STYQLWK 3 1.7 0.95484 -0.94814 0 0 0 0 0 0 0 5.12648 0 0 8.74039 0 Q3ZCQ3 F174B_HUMAN Membrane protein FAM174B FAM174B Homo sapiens (Human) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] AAVIVAFAFTTLLIACLLLR;MRAVPLPAPLLPLLLLALLAAPAAR;RAVPLPAPLLPLLLLALLAAPAARASR 3 30.2 0.71345 0.14852 0 5.478 0 0 0 0 0 0 7.65635 6.94918 0 0 Q3ZCT1 ZN260_HUMAN Zinc finger protein 260 (Zfp-260) ZNF260 ZFP260 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KMHTGEK;MHTGEKSHECTECGK 2 3.9 0.95251 -0.75329 0 0 0 3.42506 0 0 0 0 0 0 7.96705 0 Q3ZCT8 KBTBC_HUMAN Kelch repeat and BTB domain-containing protein 12 (Kelch domain-containing protein 6) KBTBD12 KLHDC6 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ELRTVHLVELLKQVR;QIGAEDLSDR 2 4 0.97409 -1.395 0 0 0 11.1914 0 0 0 0 0 9.20053 0 0 Q3ZCV2 CMAP2_HUMAN Ciliary microtubule-associated protein 2 (Lymphocyte expansion molecule) CIMAP2 LEM LEXM C1orf177 Homo sapiens (Human) GLTGNYYPGPGNYGEK;LTQLPHFQYQAIMKEK;TLATSGPSFWLPQEK 3 11.2 0.41369 0.20126 0 0 0 5.83704 9.78241 0 6.03413 0 0 0 0 0 Q3ZCX4 ZN568_HUMAN Zinc finger protein 568 ZNF568 Homo sapiens (Human) embryonic placenta morphogenesis [GO:0060669]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" CNECGKAFIQMSNLIR;VTSISKKILIK 2 4.2 0.91608 -0.37299 0 0 0 0 0 0 9.47423 0 0 0 5.24819 0 Q3ZCX4 ZN568_HUMAN Zinc finger protein 568 ZNF568 Homo sapiens (Human) embryonic placenta morphogenesis [GO:0060669]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" AFTRPSHLFR;GSELTRHQRAHTGEKPYECK;HQKVHTGERPHKCK 3 7.7 0.8759 -0.1292 0 0 0 0 0 0 10.4554 0 9.73657 6.85947 0 0 Q3ZLR7 SP201_HUMAN Transcription factor SPT20 homolog-like 1 SUPT20HL1 FAM48B1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] EGKPTPPAP;LLYNKQKMNTDPMK 2 2.8 0.98117 -1.756 0 0 0 0 8.81919 0 0 0 0 0 0 0 Q3ZM63 ETDA_HUMAN Embryonic testis differentiation protein homolog A ETDA Homo sapiens (Human) MDKEVPKGSPR 1 18.6 0.96767 -1.2967 0 11.0878 0 0 0 0 0 0 0 0 0 0 Q400G9 AMZ1_HUMAN Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1) AMZ1 KIAA1950 Homo sapiens (Human) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] LQHVLGFRLIER 1 2.4 0.95326 -0.72691 0 0 12.0302 0 0 0 0 0 0 0 0 0 Q401N2 ZACN_HUMAN Ligand-gated cation channel ZACN (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) (Zinc-activated channel) ZACN L2 LGICZ LGICZ1 ZAC Homo sapiens (Human) monoatomic ion transmembrane transport [GO:0034220]; response to zinc ion [GO:0010043] plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; ligand-gated monoatomic cation channel activity [GO:0099094]; ligand-gated monoatomic ion channel activity [GO:0015276]; pH-gated monoatomic ion channel activity [GO:0160128]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270] GVKGSQR 1 1.7 0.90363 -0.26671 0 10.1903 0 0 0 0 0 0 0 0 0 0 Q401N2 ZACN_HUMAN Ligand-gated cation channel ZACN (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) (Zinc-activated channel) ZACN L2 LGICZ LGICZ1 ZAC Homo sapiens (Human) monoatomic ion transmembrane transport [GO:0034220]; response to zinc ion [GO:0010043] plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; ligand-gated monoatomic cation channel activity [GO:0099094]; ligand-gated monoatomic ion channel activity [GO:0015276]; pH-gated monoatomic ion channel activity [GO:0160128]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270] AGAAGLR 1 2.6 0.68596 0.16249 0 0 0 0 0 0 0 0 8.78937 0 0 0 Q460N5 PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) PARP14 BAL2 KIAA1268 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714] FLVFFYPEDVRQK;FSSKNQLK;FVDDCTKHHSIK;GPSADVYKAKCEIQEK;LQMYFQSPK;TWQADTSTTLSSIR;VLERKNHELVWQGK 7 4.8 0.97844 -2.1207 0 0 0 9.82845 9.55054 0 0 0 0 7.46622 10.253 0 Q460N5 PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) PARP14 BAL2 KIAA1268 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714] FSSKNQLK;YLRRLLRPLQMLLVK 2 2.9 0.50791 0.18793 0 0 0 0 0 5.46721 0 0 0 0 0 0 Q494U1 PKHN1_HUMAN Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein) PLEKHN1 CLPABP Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of apoptotic process [GO:0043065]; response to hypoxia [GO:0001666] cytoskeleton [GO:0005856]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786] GALQSRAAQR;GPVTPLHLDLTQLHR 2 4.1 0.98056 -1.6372 0 0 0 8.90593 0 0 0 0 0 0 0 11.5845 Q494V2 CP100_HUMAN Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37) CFAP100 CCDC37 Homo sapiens (Human) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159] axonemal doublet microtubule [GO:0097545]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514] dynein complex binding [GO:0070840] GPGIKGKASSMWAK;LSPKEWLEEQEKK;MSEIPSTIVSKNMTNDK;QLQLEDK 4 8.3 0.95504 -0.87753 0 0 0 0 0 6.206 0 9.56737 0 0 9.02622 0 Q494X3 ZN404_HUMAN Zinc finger protein 404 ZNF404 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFRRHSHLTEHQK;LYRHMCLHQK;SHTGEKPHECMECGKAFGK;TFRLNSQLIYHQTIHTGLKPYVCK 4 12 0.95195 -0.7451 0 0 5.2791 7.8125 8.97739 0 0 8.22911 0 0 0 0 Q495B1 AKD1A_HUMAN Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) signal transduction [GO:0007165] SQLTATSASR 1 1.9 0.89768 -0.23264 0 0 0 0 0 0 0 0 0 0 10.1176 0 Q495C1 RN212_HUMAN Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212) RNF212 Homo sapiens (Human) chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131] synaptonemal complex [GO:0000795] metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789] KSVLQIEQLQSMR 1 4.4 0.92157 -0.44301 0 0 0 0 0 0 0 0 0 0 0 8.62483 Q495C1 RN212_HUMAN Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212) RNF212 Homo sapiens (Human) chiasma assembly [GO:0051026]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131] synaptonemal complex [GO:0000795] metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789] ETSQYLRLSR;LSRGCCRLK 2 5.9 0.98004 -1.8662 0 0 0 0 0 10.3813 0 0 0 8.82216 0 0 Q495M3 S36A2_HUMAN Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1) SLC36A2 PAT2 TRAMD1 Homo sapiens (Human) amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; vacuolar membrane [GO:0005774] amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297] LYMLSFLPFLVLLVLIRNLR 1 4.1 0.81692 -0.01737 0 0 0 0 0 0 0 0 8.0359 0 0 0 Q495M9 USH1G_HUMAN pre-mRNA splicing regulator USH1G (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein) USH1G SANS Homo sapiens (Human) equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; regulation of clathrin-dependent endocytosis [GO:2000369]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; Cajal body [GO:0015030]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; photoreceptor cell cilium [GO:0097733]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; spectrin binding [GO:0030507] IDLEALMLCSDLDLR 1 3.3 0.58363 0.17983 0 0 0 0 7.49625 0 0 0 0 0 0 0 Q495T6 MMEL1_HUMAN "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) protein processing [GO:0016485]; proteolysis [GO:0006508] extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GTPMHPK;SEGPVGMVESAGRAGQK;VGAQRSLRK;YSIFDVLR 4 5.3 0.97301 -2.6592 0 9.95677 0 0 11.3798 0 0 10.2983 0 0 0 0 Q495W5 FUT11_HUMAN "Alpha-(1,3)-fucosyltransferase 11 (EC 2.4.1.-) (Fucosyltransferase XI) (Fuc-TXI) (FucT-XI) (Galactoside 3-L-fucosyltransferase 11) (Fucosyltransferase 11)" FUT11 Homo sapiens (Human) fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] DWMPNNHSVILIDDFESPQK;RPVPPPMERAEWR 2 6.7 0.8141 -0.0061309 0 0 7.24897 0 0 0 0 0 0 0 7.0782 0 Q495X7 TRI60_HUMAN Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33) TRIM60 RNF129 RNF33 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytoplasm [GO:0005737]; cytosol [GO:0005829] SUMO-ubiquitin ligase activity [GO:0140082]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KAVRYER 1 1.5 0.97818 -1.5293 0 0 0 0 0 10.7292 0 0 0 0 0 0 Q495Z4 ASAS1_HUMAN Putative uncharacterized protein ASB16-AS1 (ASB16 antisense RNA 1) (ASB16 antisense gene protein 1) ASB16-AS1 C17orf65 Homo sapiens (Human) HAPGTEPHVAPGRAPPPR 1 9.3 0.81651 -0.017057 0 0 0 0 0 0 8.51696 0 0 0 0 0 Q496J9 SV2C_HUMAN Synaptic vesicle glycoprotein 2C SV2C KIAA1054 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of synaptic vesicle exocytosis [GO:2000300] dopaminergic synapse [GO:0098691]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] ARGQPEKVFTVNK;SVTFKDSVFK 2 3.2 0.96451 -1.2315 0 0 0 0 0 0 0 0 0 0 8.5504 0 Q496M5 PLK5_HUMAN Inactive serine/threonine-protein kinase PLK5 (Polo-like kinase 5) (PLK-5) PLK5 PLK5P FG060302 Homo sapiens (Human) cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; defense response to tumor cell [GO:0002357]; positive regulation of neuron projection development [GO:0010976]; regulation of apoptotic process [GO:0042981]; regulation of G1/S transition of mitotic cell cycle [GO:2000045] cytoplasm [GO:0005737]; nucleolus [GO:0005730] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] RPEVEAALR 1 3 0.87119 -0.10165 0 0 0 0 0 0 12.3015 0 0 0 0 0 Q496Y0 LONF3_HUMAN LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127) LONRF3 RNF127 Homo sapiens (Human) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AGQQPPPPLRVNVVLSGLLGK;NVPIFVCTMAYPTVPCPLHIFEPCYRLMIR;VLAFISRNQN 3 8 0.98041 -1.8696 0 0 0 0 0 0 0 0 0 0 0 9.01002 Q499Z3 SLNL1_HUMAN Schlafen-like protein 1 SLFNL1 Homo sapiens (Human) ATP binding [GO:0005524] LTVHTPK;MKALMMEK 2 3.7 0.97662 -2.243 0 0 0 0 0 9.52203 0 0 0 0 0 0 Q49A17 GLTL6_HUMAN Polypeptide N-acetylgalactosaminyltransferase-like 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 17) (GalNAc-T17) (pp-GaNTase 17) (Protein-UDP acetylgalactosaminyltransferase 17) (Putative polypeptide N-acetylgalactosaminyltransferase 17) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17) GALNTL6 GALNT17 Homo sapiens (Human) protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] AGAGHQR;RIPIPPELQR;RPEYRHLSTGDISAQK 3 5.7 0.88141 -0.15316 0 0 0 0 8.26547 8.84207 0 11.7895 0 0 0 10.0286 Q49A26 GLYR1_HUMAN Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) GLYR1 HIBDL NDF NP60 NPAC Homo sapiens (Human) transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786] chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; nucleosome binding [GO:0031491] DEKDLTIPESSTVK;DLTIPESSTVK;FLEAPVSGNQQLSNDGMLVILAAGDR;GLYEDCSSCFQAMGK;LSLSEGK;TAEKEGARLGR;YPPWPGKIVNPPK 7 15.7 0.97553 -3.5833 0 0 0 7.19535 0 0 0 0 0 10.6148 0 11.6618 Q49A33 Z876P_HUMAN Putative zinc finger protein 876 ZNF876P Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFYRSSHLTEHK;IHTAEKPYKCKECGK;RIHTGEKPYTCEECGK 3 21.2 0.93655 -0.5267 0 0 0 0 0 0 0 0 0 0 9.911 0 Q49A88 CCD14_HUMAN Coiled-coil domain-containing protein 14 CCDC14 Homo sapiens (Human) protein localization to centrosome [GO:0071539]; substantia nigra development [GO:0021762] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737] ETHLDSQTHR;SENAQLR;SLLNIHDK;SPTQSQPAFLATNEEK 4 4.3 0.95506 -0.90122 0 3.66334 0 0 0 0 0 0 0 10.5164 7.3637 0 Q49A92 CH034_HUMAN Uncharacterized protein C8orf34 (Protein VEST-1) C8orf34 Homo sapiens (Human) MASHPQTR 1 2.8 0.93728 -0.56116 0 9.71082 0 0 0 0 0 0 0 0 0 0 Q49AA0 ZFP69_HUMAN Zinc finger protein 69 homolog (Zinc finger protein 642) ZFP69 ZNF642 Homo sapiens (Human) lipid metabolic process [GO:0006629]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFRQRIHLSNHK;AYLTHHQRIHTGERPYK;IETIESTAK;MFEGEALLSQDAEDVK 4 10.3 0.9734 -1.4157 0 0 0 0 0 0 11.4221 0 0 10.4724 9.67823 0 Q49AG3 ZBED5_HUMAN Zinc finger BED domain-containing protein 5 (Transposon-derived Buster1 transposase-like protein) ZBED5 Buster1 Homo sapiens (Human) DNA binding [GO:0003677]; metal ion binding [GO:0046872] FISNSNK;MFDEQYSK 2 2.2 0.95213 -0.71221 1.47197 0 0 0 9.30702 0 0 0 0 0 6.49142 0 Q49AJ0 F135B_HUMAN Protein FAM135B FAM135B C8orfK32 Homo sapiens (Human) ALEETPK 1 0.5 0.69795 0.16173 11.6862 0 0 0 11.269 8.75926 9.95191 9.27757 8.86378 0 0 0 Q49AM3 TTC31_HUMAN Tetratricopeptide repeat protein 31 (TPR repeat protein 31) TTC31 Homo sapiens (Human) LAEELVAEEERMK;LNPQDHR;MGQEEESPPR 3 5.8 0.97881 -2.0478 0 0 0 0 0 0 9.32019 0 0 12.1199 3.58352 0 Q49AN0 CRY2_HUMAN Cryptochrome-2 CRY2 KIAA0658 Homo sapiens (Human) blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein import into nucleus [GO:0006606]; regulation of circadian rhythm [GO:0042752]; regulation of sodium-dependent phosphate transport [GO:2000118]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416] Cry-Per complex [GO:1990512]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] blue light photoreceptor activity [GO:0009882]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864]; single-stranded DNA binding [GO:0003697]; transcription cis-regulatory region binding [GO:0000976] MPAPPGR;QIYQQLSRYR 2 3.2 0.91462 -0.33057 0 0 0 0 0 0 0 0 9.13366 0 0 0 Q49AS3 L37A5_HUMAN Putative protein LRRC37A5P (Leucine-rich repeat-containing 37 member A5 pseudogene) LRRC37A5P C9orf29 Homo sapiens (Human) LLSEQQELR 1 8.5 0.84358 -0.054558 0 0 0 0 0 0 0 0 0 4.85908 0 0 Q49MG5 MAP9_HUMAN Microtubule-associated protein 9 (Aster-associated protein) MAP9 ASAP Homo sapiens (Human) mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] astral microtubule [GO:0000235]; axon [GO:0030424]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; spindle midzone [GO:0051233] microtubule binding [GO:0008017] GEALQAFEKWK;IESENLRIQNEQK;KSHMEEK 3 4.8 0.95281 -0.77383 12.1709 0 0 0 0 0 0 0 0 0 10.6821 0 Q4AC94 C2CD3_HUMAN C2 domain-containing protein 3 C2CD3 Homo sapiens (Human) brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] KAQNLVLPNRK;LPLHQFYMSFKDAK;TLNEITTVTDK 3 1.5 0.95931 -1.038 2.30007 0 0 0 0 0 0 0 0 0 0 11.8133 Q4AC94 C2CD3_HUMAN C2 domain-containing protein 3 C2CD3 Homo sapiens (Human) brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] KAQNLVLPNRK;LPLHQFYMSFKDAK;LTTSPLSSQTPEAWRR 3 2.2 0.48398 0.18996 0 0 0 0 0 0 0 8.75338 0 0 0 0 Q4AC99 1A1L2_HUMAN Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (ACC synthase-like protein 2) ACCSL Homo sapiens (Human) amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] FLDNKLLLSR;LLYCRFLDNK;QGLSLEERR;YLDPCTFEEERLLYCR 4 6.2 0.98089 -1.7392 12.4779 0 3.66993 0 0 9.00899 0 10.1722 9.63003 0 0 9.22846 Q4ADV7 RIC1_HUMAN Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) RIC1 CIP150 KIAA1432 Homo sapiens (Human) "cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DRSGPQIREK;EPAKSSTQFGSYK;QYPDIWNK;TPEQTSPRAEESR;TVGEQLLK;VDNFVIALKRLHK 6 4.6 0.97593 -5.1648 9.23778 0 0 0 0 0 0 12.9927 7.05039 12.8607 0 0 Q4AE62 QTMAN_HUMAN tRNA-queuosine alpha-mannosyltransferase (QTMAN) (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) (Mannosyltransferase-like protein Xa) (Mat-Xa) GTDC1 QTMAN Homo sapiens (Human) regulation of translation [GO:0006417]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] tRNA-queuosine(34) beta-mannosyltransferase activity [GO:0016438] LIPDHRPK;LIPDHRPKDLESIIRPK;SILIIEAFYGGSHK;YFQLNICILHLNSFQKGSR 4 13.3 0.93337 -0.51316 8.16641 0 0 0 10.4459 0 0 9.51469 12.5117 9.39146 0 9.33313 Q4FZB7 KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) KMT5B SUV420H1 CGI-85 Homo sapiens (Human) DNA repair [GO:0006281]; methylation [GO:0032259]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830] "condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047] EPKVVLYKNLPIK;GEAKCHKSDTGMSK;LEPNTLNGYK;LKKPAKPLLSKIK 4 5.6 0.88119 -0.15045 0 0 2.95224 0 6.51696 0 0 5.60801 0 10.1244 0 0 Q4G0A6 MINY4_HUMAN Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) MINDY4 C7orf67 FAM188B Homo sapiens (Human) protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] IDKLHSEPSLDVKR;VLHLEFLYKENKAK 2 3.7 0.74423 0.091837 0 0 0 0 0 7.79461 0 0 0 11.1308 0 0 Q4G0F5 VP26B_HUMAN Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) VPS26B Homo sapiens (Human) "cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; retrograde transport, endosome to Golgi [GO:0042147]" "cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; postsynaptic early endosome [GO:0098842]; postsynaptic recycling endosome [GO:0098837]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]" DVIVGKIYFLLVRIK;IYFLLVRIKIK 2 5.1 0.77085 0.052498 0 0 0 0 4.71194 0 5.01547 0 0 0 0 0 Q4G0J3 LARP7_HUMAN La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) LARP7 HDCMA18P Homo sapiens (Human) "box C/D sno(s)RNA 3'-end processing [GO:0000494]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U6 2'-O-snRNA methylation [GO:1990438]" 7SK snRNP [GO:0120259]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] 7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] ASMASLK;FLREQIEKSR;LEILSGDHEQRYWQK;QVDFWFGDANLHK 4 7.7 0.97342 -2.973 0 0 0 5.37754 0 0 0 0 9.75231 0 9.88033 0 Q4G0N4 NAKD2_HUMAN "NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)" NADK2 C5orf33 MNADK NADKD1 Homo sapiens (Human) NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803] YTHSFPEALQK 1 2.5 0.89669 -0.23455 0 0 0 0 9.3285 0 0 0 0 0 0 0 Q4G0N8 SL9C1_HUMAN Solute carrier family 9 member C1 (Na(+)/H(+) exchanger 10) (NHE-10) (Sodium/hydrogen exchanger 10) (Solute carrier family 9 member 10) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) SLC9C1 SLC9A10 Homo sapiens (Human) cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283] motile cilium [GO:0031514]; plasma membrane [GO:0005886] monoatomic ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] ILRIFKLIAPK;MWLKLGLAITAR;NKDYINFIQEK;SQILFHGVLVCLITLVVNRFILPVAVTILGLR;YIFNETEVIVFIKVVQFFR 5 7.2 0.95941 -1.0422 0 0 8.98502 8.6359 0 2.90389 0 0 7.07756 5.93515 0 0 Q4G0P3 HYDIN_HUMAN Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930] AEGYTMNVEIK;AGETFGR;EQTMSEKEELNK;GRSTLPICHFDLK;GSLTPTEKPTNVQVFFHAKK;IDQVFEIQKDK;ILLVRNIGNKNAVFHIK;IVDIFEVEPSK;LLLGHSEKLPLILK;QVPPLTK;SNVQVKFMPK;TFANQRRLVQGDSK;TYELTLKDVQNILMYWDRK;VIPSGIIK;VTIPTMTLSRGK 15 3.6 0.97831 -7.6009 0 6.81583 15.0505 8.4232 10.1245 7.68538 10.4534 0 13.1654 5.50795 11.5024 11.5376 Q4G0S4 C27C1_HUMAN "Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase)" CYP27C1 Homo sapiens (Human) retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] "11-cis retinal binding [GO:0005502]; 11-cis-retinal 3,4-desaturase activity [GO:0061899]; all-trans retinal 3,4-desaturase activity [GO:0061897]; all-trans retinal binding [GO:0005503]; all-trans retinoic acid 3,4-desaturase activity [GO:0061898]; all-trans retinol 3,4-desaturase activity [GO:0061896]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid binding [GO:0001972]" EIVKNLGERHVPTAADVPK;WLRKGDLDR 2 5.2 0.96635 -1.2742 0 0 12.0391 0 0 0 0 0 10.2201 0 0 0 Q4G0S7 CC152_HUMAN Coiled-coil domain-containing protein 152 CCDC152 Chr5_400 Homo sapiens (Human) LINDFSQIEK;LQLEFDAK;LQLEFDAKLAR;LSVGKDSHLK;LVSEMKIK 5 15.4 0.97583 -3.4268 0 0 0 9.28526 0 0 11.9904 0 0 0 0 0 Q4G0T1 SRCRM_HUMAN Scavenger receptor cysteine-rich domain-containing protein SCART1 (Scavenger receptor family member expressed on T cells 1) SCART1 Homo sapiens (Human) T cell mediated immunity [GO:0002456] brush border [GO:0005903]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] LDNNFRSGCDLR;NVNGVDR;VLDDAWDLR;VTQAMQR 4 3.4 0.97525 -1.4577 0 0 0 0 6.38915 0 11.4411 3.15887 0 0 0 8.21694 Q4G0U5 PCDP1_HUMAN Cilia- and flagella-associated protein 221 (Primary ciliary dyskinesia protein 1) CFAP221 PCDP1 Homo sapiens (Human) cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; manchette [GO:0002177]; sperm flagellum [GO:0036126] calmodulin binding [GO:0005516] AGEKLLEEMR;ELTEEWQKACAKYK;YFEINYVR 3 3.8 0.97483 -3.2046 0 0 0 0 0 0 0 0 0 10.4948 0 0 Q4G0X4 KCD21_HUMAN BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21) KCTD21 Homo sapiens (Human) negative regulation of smoothened signaling pathway [GO:0045879]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin family protein binding [GO:0097602]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802] DGKVFRYILNFLR 1 5 0.86534 -0.087613 0 4.10685 0 0 0 0 7.34899 0 0 0 6.59349 0 Q4G0X9 CCD40_HUMAN Coiled-coil domain-containing protein 40 CCDC40 KIAA1640 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] ATLLNQLVEAEHQIMLWEKKIQLAK;EIEHHMK;LALIATILDRVR;LQQEMVK;TTKYFNQLILR;VESKIEQEK 6 6.2 0.9739 -3.0131 0 0 12.7827 0 0 0 2.64929 9.0359 0 0 12.6436 0 Q4G0Z9 MCMD2_HUMAN Minichromosome maintenance domain-containing protein 2 (MCM domain-containing protein 2) MCMDC2 C8orf45 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; double-strand break repair via break-induced replication [GO:0000727]; meiotic cell cycle [GO:0051321] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677] IIGIPTCVK;QIVEIIATK 2 2.6 0.95262 -0.73716 0 0 16.3206 0 0 0 11.6138 0 0 0 0 0 Q4G148 GXLT1_HUMAN Glucoside xylosyltransferase 1 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 3) GXYLT1 GLT8D3 Homo sapiens (Human) O-glycan processing [GO:0016266] membrane [GO:0016020] "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]" LFKPCASQRLFLPLILK 1 3.9 0.92283 -0.44238 0 0 5.89356 0 0 0 0 0 0 0 0 0 Q4G1C9 GRPL2_HUMAN GLIPR1-like protein 2 GLIPR1L2 Homo sapiens (Human) extracellular space [GO:0005615]; membrane [GO:0016020] FMTWDVALSR 1 4 0.89286 -0.22262 0 0 0 0 0 8.69206 0 0 0 0 0 0 Q4G1C9 GRPL2_HUMAN GLIPR1-like protein 2 GLIPR1L2 Homo sapiens (Human) extracellular space [GO:0005615]; membrane [GO:0016020] MLITMILHR 1 3.2 0.93577 -0.5372 0 0 0 0 10.4975 10.5725 0 0 0 11.1663 0 0 Q4J6C6 PPCEL_HUMAN Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) PREPL KIAA0436 Homo sapiens (Human) "Golgi to plasma membrane protein transport [GO:0043001]; proteolysis [GO:0006508]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde transport, endosome to Golgi [GO:0042147]" cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] LVPMTVFHK 1 1.2 0.92155 -0.43971 0 0 0 0 9.87155 0 0 0 0 0 0 0 Q4JDL3 PTN20_HUMAN Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48) PTPN20 PTPN20A PTPN20B Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] histone H2AXY142 phosphatase activity [GO:0140793] CYHYWPISLKKPLELK;VFLENYQILQYFIIR;VPLGKSK 3 9 0.48969 0.18946 0 0 8.95396 0 0 0 7.8899 0 0 10.1697 0 0 Q4KMG0 CDON_HUMAN Cell adhesion molecule-related/down-regulated by oncogenes CDON CDO Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; embryonic body morphogenesis [GO:0010172]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; lens development in camera-type eye [GO:0002088]; myoblast fusion [GO:0007520]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle satellite cell differentiation [GO:0014816]; smoothened signaling pathway [GO:0007224] plasma membrane [GO:0005886] CAAYNPVTHQLK;TSNWLVAAEDIPPSK 2 2.1 0.91443 -0.33529 0 0 0 0 0 0 10.3317 0 9.88874 0 0 0 Q4KMP7 TB10B_HUMAN TBC1 domain family member 10B (Rab27A-GAP-beta) TBC1D10B FP2461 Homo sapiens (Human) "regulation of GTPase activity [GO:0043087]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GIPSSLR;RHGAPAAPSPPPRGSR;TLPWASVLR 3 4 0.96378 -1.2054 0 5.38405 10.3487 0 0 0 0 0 0 0 0 0 Q4KMQ1 TPRN_HUMAN Taperin TPRN C9orf75 Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] cytoplasm [GO:0005737]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; stereocilium [GO:0032420]; stereocilium base [GO:0120044] actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] GSNTFTVVPK;VPGLAKNSR 2 2.7 0.95212 -0.75415 0 10.562 0 9.31501 0 0 0 0 0 0 0 0 Q4KMQ2 ANO6_HUMAN Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) ANO6 TMEM16F Homo sapiens (Human) "activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; sodium ion transmembrane transport [GO:0035725]" cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244] LLHENHLKDMTK 1 1.3 0.92459 -0.44851 0 0 0 0 0 3.28769 0 0 0 0 0 0 Q4KMZ1 IQCC_HUMAN IQ domain-containing protein C IQCC Homo sapiens (Human) GLKPRNHCPR;GLKPRNHCPRK;ILEDQTPR;ILEDQTPRGLKPRNHCPR 4 4.1 0.97529 -2.3732 0 0 0 0 0 8.06269 0 7.67292 0 0 0 0 Q4KWH8 PLCH1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)" PLCH1 KIAA1069 PLCL3 Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; phosphatidylinositol phospholipase C activity [GO:0004435] MMQLNRAK;NLSPEKVER 2 1 0.97473 -3.1173 0 0 0 9.578 0 0 0 0 11.0694 0 0 0 Q4L180 FIL1L_HUMAN Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) FILIP1L COL4A3BPIP DOC1 GIP90 Homo sapiens (Human) protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] LKDMKAIEDDLMK;LQSLEAIEKDFLKNK;MDLALLEAQYGFVTPK;NKLNQDSGK;NKLNQDSGKSTTALHQENNK 5 5.5 0.97839 -2.0714 0 0 0 0 0 0 0 0 0 3.26263 1.72927 11.2703 Q4L235 ACSF4_HUMAN Beta-alanine-activating enzyme (EC 6.2.1.-) (Acyl-CoA synthetase family member 4) (Protein NRPS998) AASDH ACSF4 U26 HSPC318 Homo sapiens (Human) amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; beta-alanine metabolic process [GO:0019482]; fatty acid metabolic process [GO:0006631] acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524] CGNFIVVGKFLNLRFVELN;DPSCVAK 2 3.1 0.98026 -1.8031 7.40633 6.28947 10.3049 0 0 0 7.03947 0 0 0 0 0 Q4LDE5 SVEP1_HUMAN "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) "epidermis development [GO:0008544]; gene expression [GO:0010467]; lymph circulation [GO:0003017]; lymph vessel morphogenesis [GO:0036303]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of platelet activation [GO:0010572]; Tie signaling pathway [GO:0048014]; tight junction organization [GO:0120193]" cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640] AIECLKPK;ETRCETPLEFLNGK;IQCFKGFK;MGSCKCGTHTGHFECICEK;SIFCSDCPR;VAIVTFSSK;VYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDK 7 2.8 0.97693 -4.87 0 8.11426 0 0 10.3347 6.39122 0 0 0 0 0 0 Q4LDG9 DNAL1_HUMAN Dynein axonemal light chain 1 (LC1) DNAL1 C14orf168 Homo sapiens (Human) outer dynein arm assembly [GO:0036158] cytoplasm [GO:0005737]; microtubule [GO:0005874]; outer dynein arm [GO:0036157] alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504] GDEEEDN;LDGTPVIK;LKILYMSNNLVK 3 14.2 0.95897 -1.0345 7.8392 0 0 0 0 7.86999 0 7.75616 0 5.59443 0 0 Q4LE39 ARI4B_HUMAN AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180 Homo sapiens (Human) establishment of Sertoli cell barrier [GO:0097368]; genomic imprinting [GO:0071514]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976] ALDEPPYLTVGTDVSAKYR;DVWSSIQGQWPK;QCKECENVK;SVSTGMK;SVSTGMKSHSTK;VQVRYGR 6 4.5 0.97573 -4.4023 0 0 12.4521 10.2498 3.99838 0 0 11.6531 0 10.4262 10.3774 0 Q4LEZ3 AARD_HUMAN Alanine and arginine-rich domain-containing protein AARD C8orf85 Homo sapiens (Human) response to testosterone [GO:0033574] AELVEMHFQNHQLAR;DDAANPE 2 14.2 0.91769 -0.35934 0 8.66491 0 0 0 0 0 0 0 0 6.79442 0 Q4U2R6 RM51_HUMAN "Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (L51mt) (MRP-L51) (bMRP-64) (bMRP64)" MRPL51 MRP64 CDA09 HSPC241 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] SFSLGVPRLIGIRLTLPPPK;VVDRWNEK 2 21.9 0.97253 -1.3645 0 0 8.93127 0 0 0 0 0 8.0348 0 0 0 Q4U2R8 S22A6_HUMAN Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1) SLC22A6 OAT1 PAHT Homo sapiens (Human) alpha-ketoglutarate transport [GO:0015742]; metanephric proximal tubule development [GO:0072237]; monoatomic anion transport [GO:0006820]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; renal tubular secretion [GO:0097254]; response to organic cyclic compound [GO:0014070]; sodium-independent organic anion transport [GO:0043252] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; antiporter activity [GO:0015297]; chloride ion binding [GO:0031404]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] EEGAKLSMEVLRASLQK 1 3 0.75926 0.070922 0 0 0 0 0 0 8.53002 0 0 0 0 0 Q4V328 GRAP1_HUMAN GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] GRIPAP1 KIAA1167 Homo sapiens (Human) "negative regulation of receptor clustering [GO:1903910]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of modification of synaptic structure [GO:1905244]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of recycling endosome localization within postsynapse [GO:0099158]" axon [GO:0030424]; blood microparticle [GO:0072562]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of postsynaptic early endosome membrane [GO:0098998]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome [GO:0098837]; presynaptic membrane [GO:0042734]; recycling endosome membrane [GO:0055038] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255] DQLEQAQEER;ETLFNDSR;GKEEELQDVRDQLEQAQEER 3 3.3 0.91514 -0.43426 6.79714 0 0 7.01011 0 0 0 0 0 9.05273 0 0 Q4V328 GRAP1_HUMAN GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] GRIPAP1 KIAA1167 Homo sapiens (Human) "negative regulation of receptor clustering [GO:1903910]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of modification of synaptic structure [GO:1905244]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of recycling endosome localization within postsynapse [GO:0099158]" axon [GO:0030424]; blood microparticle [GO:0072562]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of postsynaptic early endosome membrane [GO:0098998]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome [GO:0098837]; presynaptic membrane [GO:0042734]; recycling endosome membrane [GO:0055038] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255] DQLEQAQEER;ETLFNDSR;GKEEPTAPASLNPK 3 5.1 0.92225 -0.44099 0 0 0 0 0 0 0 0 0 0 0 10.2335 Q4VC05 BCL7A_HUMAN B-cell CLL/lymphoma 7 protein family member A BCL7A Homo sapiens (Human) chromatin remodeling [GO:0006338]; motor behavior [GO:0061744]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; neuron projection arborization [GO:0140058]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; SWI/SNF complex [GO:0016514] KWVTVGDTSLR;VMAAIEK 2 8.6 0.87837 -0.14408 0 0 0 0 8.21956 0 0 9.32802 0 0 0 0 Q4VC12 MSS51_HUMAN "Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17)" MSS51 ZMYND17 Homo sapiens (Human) metal ion binding [GO:0046872] ALGIDVR;VCQELRLVAVDR 2 4.1 0.82527 -0.020451 0 0 0 0 0 0 0 9.37541 0 8.40518 0 0 Q4VC31 MIX23_HUMAN Protein MIX23 (Coiled-coil domain-containing protein 58) MIX23 CCDC58 Homo sapiens (Human) mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] TIDDRIVHELNTTVPTASFAGK 1 15.3 0.83009 -0.025077 0 0 0 0 0 0 10.0418 0 0 0 0 0 Q4VC44 FWCH1_HUMAN FLYWCH-type zinc finger-containing protein 1 FLYWCH1 KIAA1552 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714] AAGEKVYWTCRDQAR;AITQGRR;DVRLDGESQ 3 7.4 0.95536 -0.83116 0 9.43867 0 0 0 0 0 0 0 8.447 0 0 Q4VCS5 AMOT_HUMAN Angiomotin AMOT KIAA1071 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell migration involved in gastrulation [GO:0042074]; cell-cell junction assembly [GO:0007043]; chemotaxis [GO:0006935]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; establishment of epithelial cell polarity [GO:0090162]; gastrulation with mouth forming second [GO:0001702]; hippo signaling [GO:0035329]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell size [GO:0045793]; positive regulation of embryonic development [GO:0040019]; positive regulation of stress fiber assembly [GO:0051496]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of small GTPase mediated signal transduction [GO:0051056]; vasculogenesis [GO:0001570] actin filament [GO:0005884]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle [GO:0001726]; stress fiber [GO:0001725] angiostatin binding [GO:0043532]; signaling receptor activity [GO:0038023] LEGEIRRMHDFNR;TISQLFAK;VLQQRSRK;VSEAYENLVKSSSK 4 4 0.95531 -0.82909 0 13.8204 13.8345 0 9.19557 0 0 12.5196 0 0 0 0 Q4VNC0 AT135_HUMAN Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5) ATP13A5 UNQ488/PRO1004 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047] late endosome membrane [GO:0031902]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203] LAEDSTWPPINR;LGGQPTEQHFWARL;VESELTFLGLLIMENRLKK 3 3.7 0.91982 -0.43693 0 0 0 0 0 0 0 10.5985 0 0 10.9843 0 Q4VNC1 AT134_HUMAN Probable cation-transporting ATPase 13A4 (EC 7.2.2.-) (P5-ATPase isoform 4) ATP13A4 UNQ3052/PRO9871 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203] IGSLEDWLSSAKIHQK;KHIMYGNQDNYINIR;KRGIFCISPQR;LAFMKGAPER;MTVIVQEMGGDR;SILYPKPVNFQLYR;YVWNYLEGQFQK;YVWNYLEGQFQKIGSLEDWLSSAK 8 7.5 0.97577 -2.3031 0 3.47573 10.4525 8.50371 6.1449 0 6.2572 0 0 0 8.74062 9.97039 Q4VX62 CF099_HUMAN Putative uncharacterized protein LINC02901 (Long intergenic non-protein coding RNA 2901) LINC02901 C6orf99 Homo sapiens (Human) AVHLLFR;GVAHPSLYLFPR 2 15.2 0.95435 -0.8867 0 0 0 0 0 0 0 10.3368 0 0 0 0 Q4VX76 SYTL3_HUMAN Synaptotagmin-like protein 3 (Exophilin-6) SYTL3 SLP3 Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267] EAILQVLYR;EAILQVLYRDQAVQNTEEERTR;KFPTGGK;LSKISVVPPTPPPVSESQCSR;NLAYGEEK;THLQHLRWKGAK 6 11.5 0.97971 -1.9965 14.7694 0 0 0 13.6303 7.21344 7.68643 0 10.7627 11.542 8.43409 0 Q4VXA5 KHDC1_HUMAN KH homology domain-containing protein 1 KHDC1 C6orf147 C6orf148 Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020] RNA binding [GO:0003723] MLSAFQRLFR 1 4.2 0.92088 -0.44634 0 0 0 3.78304 0 0 0 0 0 0 0 0 Q4VXU2 PAP1L_HUMAN Polyadenylate-binding protein 1-like PABPC1L C20orf119 Homo sapiens (Human) cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] AVTEMNGR;FEQMKQDR;FSPAGPILSIR;IVGTKPLYVALAQRKEER;NLDDSIDDDKLRK;SGVGNIFIK;YQGVNLYVK 7 12.4 0.95568 -0.9425 0 0 10.1298 0 0 0 8.9265 0 0 0 0 0 Q4W5G0 TIGD2_HUMAN Tigger transposable element-derived protein 2 TIGD2 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] AFKGTDLSNLPVTYYSQK 1 3.4 0.91965 -0.43788 0 0 0 0 8.05517 0 0 0 0 0 0 0 Q4W5P6 SIM43_HUMAN Small integral membrane protein 43 (Nodal enhanced mesendoderm micropeptide) (NEMEP) SMIM43 TMEM155 Homo sapiens (Human) mesendoderm development [GO:0048382]; positive regulation of D-glucose transmembrane transport [GO:0010828] plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] EPWGFSREQAV 1 17.5 0.88132 -0.14836 0 0 0 9.16073 0 0 0 0 0 0 0 0 Q4ZG55 GREB1_HUMAN Protein GREB1 (Gene regulated in breast cancer 1 protein) GREB1 KIAA0575 Homo sapiens (Human) morphogenesis of an epithelium [GO:0002009] extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] EYEMAIYK;LLLSGPPQIGK;LPLVTDKSHEYIK;QCPCGHGLMVLLRVPCSPLAVVAYERLAHVR;WSSKTRASEVQEPFSR 5 4.1 0.97341 -2.6344 8.86357 0 0 0 0 7.92896 10.6184 0 0 10.6163 0 0 Q4ZHG4 FNDC1_HUMAN Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) extracellular region [GO:0005576] KISEEDELDVPDDISVR;KMNYVPLTRDER;LSVAWKAPR;TLRPPSR;WSTQASSVTHLPIENLKPNTR;YLQDSHGNPLR;YLQDSHGNPLRIK 7 4.2 0.97379 -2.4238 5.21894 0 0 7.93546 10.2533 0 0 0 8.1046 0 0 0 Q4ZIN3 MBRL_HUMAN Membralin (Transmembrane protein 259) TMEM259 C19orf6 Homo sapiens (Human) positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] TPNLNPNPLINVR 1 2.1 0.8968 -0.23554 0 0 0 0 0 0 0 0 0 0 8.55171 0 Q502W6 VWA3B_HUMAN von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B) VWA3B Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] DLSAKTHSR 1 0.7 0.96662 -1.2927 0 0 4.29668 0 0 0 0 0 11.9687 0 0 0 Q502W7 CCD38_HUMAN Coiled-coil domain-containing protein 38 CCDC38 Homo sapiens (Human) acrosome assembly [GO:0001675]; intraciliary anterograde transport [GO:0035720]; sperm flagellum assembly [GO:0120316] centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm head [GO:0061827] ubiquitin-modified histone reader activity [GO:0061649] AVAQPKK;DIAMRERQLK;HWQIQQALKR;IFFRDLFLVK;SKANIILPKILAK 5 8.9 0.96568 -1.2593 0 10.7796 0 0 0 0 0 0 3.84036 0 0 6.4367 Q504Q3 PAN2_HUMAN PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) PAN2 KIAA0710 USP52 Homo sapiens (Human) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] FLAWYFLDLK;FVGHGLQKDFR;LIQRWNR;NLNSRYNLNIK;RNLNSRYNLNIK;VINLMVPK;VLKGLYEK 7 4.7 0.97607 -4.3141 0 0 0 0 9.25776 9.31936 11.5776 0 0 7.19081 0 0 Q504Y0 S39AC_HUMAN Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Homo sapiens (Human) intracellular monoatomic cation homeostasis [GO:0030003]; neural tube formation [GO:0001841]; neuron projection extension [GO:1990138]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; response to decreased oxygen levels [GO:0036293]; signal transduction [GO:0007165]; zinc ion import across plasma membrane [GO:0071578] extracellular vesicle [GO:1903561]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] EDFKQMSPGIIQRWSFSIAVR 1 5.2 0.52389 0.18665 0 3.04703 0 0 0 0 0 0 0 0 6.93133 0 Q504Y2 PKDCC_HUMAN "Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" PKDCC SGK493 VLK Homo sapiens (Human) bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672] AFVVTNQTTWTGR 1 2.6 0.80463 0.013589 0 0 0 8.92573 0 0 0 0 0 7.17063 0 0 Q50LG9 LRC24_HUMAN Leucine-rich repeat-containing protein 24 LRRC24 Homo sapiens (Human) positive regulation of synapse assembly [GO:0051965] external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] ALEAGAFRAQPRLLELALTSNR;LTENPWR;MALRAPALLPLLLLLLPLR 3 9.4 0.95539 -0.87999 0 0 0 0 4.13512 0 0 0 0 7.97631 0 0 Q52LD8 RFTN2_HUMAN Raftlin-2 (Raft-linking protein 2) RFTN2 C2orf11 Homo sapiens (Human) dsRNA transport [GO:0033227]; response to exogenous dsRNA [GO:0043330] plasma membrane [GO:0005886] VVLLRLKLSPK 1 2.2 0.29292 0.25291 0 0 0 4.66681 0 5.44688 0 0 0 10.0836 0 0 Q52LG2 KR132_HUMAN Keratin-associated protein 13-2 KRTAP13-2 KAP13.2 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] GCQEICWEPTSCQTSYVESSPCQTSCYRPR 1 17.1 0.81535 -0.0023726 0 0 8.91331 0 0 0 0 0 0 0 0 0 Q52LJ0 FA98B_HUMAN Protein FAM98B FAM98B Homo sapiens (Human) "positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] identical protein binding [GO:0042802]; protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723] GYGDPYGGGGGGGGGGGGGGGYR;GYGDPYGGGGGGGGGGGGGGGYRR;TSSGTSR 3 7.2 0.17887 0.3395 0 0 0 0 0 0 0 0 0 8.73003 6.25233 0 Q52LR7 EPC2_HUMAN Enhancer of polycomb homolog 2 (EPC-like) EPC2 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777] ELYATPATLHNGNHHKVQECK;LYKGEFKQPK 2 3.8 0.97755 -1.5173 0 0 0 0 0 0 0 0 0 6.06676 0 0 Q52LW3 RHG29_HUMAN Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) ARHGAP29 PARG1 Homo sapiens (Human) negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165] ALCLQGIYRVCGNK;CRDCEGIVVFQGVECEECLLVCHRK;IAHKQKK;KQNALGK;TLVFQCDLTLK 5 5.1 0.9787 -2.0592 10.7846 0 0 0 0 0 7.1103 11.085 0 0 9.74426 0 Q52M58 CN177_HUMAN Testis-specific protein LINC02914 (Long intergenic non-protein coding RNA 2914) LINC02914 C14orf177 Homo sapiens (Human) cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634] ARCCGECSTCFCTEEK;CCGECSTCFCTEEK 2 12.8 0.71599 0.14228 0 0 0 0 5.11341 0 0 0 5.4444 0 0 0 Q52MB2 CC184_HUMAN Coiled-coil domain-containing protein 184 CCDC184 C12orf68 Homo sapiens (Human) cytoplasm [GO:0005737] DPEDEEEEEEEK 1 6.2 0.8077 0.0085186 0 0 0 0 8.14466 7.90929 0 0 0 12.4102 12.1968 0 Q52WX2 SBK1_HUMAN Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3 domain-binding kinase 1) SBK1 Homo sapiens (Human) cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EVFRFLK 1 1.7 0.9032 -0.26586 0 10.7001 0 0 0 0 0 0 0 0 0 0 Q537H7 SPT45_HUMAN Spermatogenesis-associated protein 45 SPATA45 C1orf227 HSD-44 HSD44 Homo sapiens (Human) TIEIMKKHGVSK 1 12.2 0.9748 -1.4363 0 0 0 0 0 9.08818 0 0 0 0 0 0 Q53EL6 PDCD4_HUMAN Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) PDCD4 H731 Homo sapiens (Human) apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; response to alkaloid [GO:0043279]; response to hormone [GO:0009725] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] RNA binding [GO:0003723] DLPELALDTPR;KGGAGGK 2 3.8 0.90964 -0.28275 0 0 0 0 12.1202 0 0 0 0 14.5372 8.18755 0 Q53EP0 FND3B_HUMAN Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) FNDC3B FAD104 NS5ABP37 UNQ2421/PRO4979/PRO34274 Homo sapiens (Human) membrane [GO:0016020] RNA binding [GO:0003723] GHSGGSGGGGSGSGPGIK;SKSSLTLQWK;TLSIAPGQCRPPRVLGRPK 3 3.9 0.98099 -1.594 3.04701 0 0 5.39232 0 0 0 2.38915 0 0 8.1821 0 Q53EQ6 TIGD5_HUMAN Tigger transposable element-derived protein 5 TIGD5 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] CWLLGLRAAFEPRPGEDSAGQPAQAEEAAEHSR 1 5.1 0.8339 -0.027246 0 0 0 0 0 0 0 0 0 0 8.82788 0 Q53EV4 LRC23_HUMAN Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7) LRRC23 LRPB7 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; radial spoke assembly [GO:0062177] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; sperm flagellum [GO:0036126] MSDEDDLEDSEPDQDDSEK;MSDEDDLEDSEPDQDDSEKEEDEK;SDEDDLEDSEPDQDDSEK;TLAFRPDQTPR 4 11.2 0.76483 0.066826 0 8.41219 0 0 0 0 0 9.42857 9.45783 6.89542 0 0 Q53EZ4 CEP55_HUMAN Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) CEP55 C10orf3 URCC6 Homo sapiens (Human) cranial skeletal system development [GO:1904888]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; midbody [GO:0030496] identical protein binding [GO:0042802] EVYVKGLLAK 1 2.2 0.98044 -1.6267 0 0 0 10.6986 0 0 0 0 0 0 0 0 Q53F19 NCBP3_HUMAN Nuclear cap-binding protein subunit 3 (Protein ELG) NCBP3 C17orf85 Homo sapiens (Human) 7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; snRNA export from nucleus [GO:0006408] cytoplasm [GO:0005737]; nuclear cap binding complex [GO:0005846]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518] mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] GLYADTR;RFHFRSEVNLAQR;YGNPNYGGMK 3 4.8 0.87391 -0.11341 0 0 0 4.56505 0 0 8.0727 7.84787 0 0 0 0 Q53F39 MPPE1_HUMAN Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) MPPE1 PGAP5 PP579 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506] cis-Golgi network [GO:0005801]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145] LLWWLQPR;NRNNPSFIMGSITPTDYTLSK 2 7.3 0.96509 -1.1396 0 0 0 0 0 0 0 0 0 11.6227 6.79416 13.2009 Q53FA7 QORX_HUMAN Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) NADP metabolic process [GO:0006739] cytosol [GO:0005829] NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; protein homodimerization activity [GO:0042803]; quinone binding [GO:0048038] IVLELPQ 1 2.1 0.9412 -0.59316 0 0 0 12.2465 0 0 5.66323 0 13.1294 13.7909 12.8033 0 Q53FD0 ZC21C_HUMAN Zinc finger C2HC domain-containing protein 1C ZC2HC1C C14orf140 FAM164C Homo sapiens (Human) metal ion binding [GO:0046872] DPVSEPSVEK;LVASNNK 2 3.7 0.21196 0.3209 12.8996 14.2966 14.1799 11.4901 11.4175 11.2179 0 13.5233 0 13.4358 11.2113 12.6606 Q53FE4 CD017_HUMAN Uncharacterized protein C4orf17 C4orf17 Homo sapiens (Human) ACSTPGSCSSGMTSTK 1 4.5 0.78269 0.026223 0 0 0 0 0 0 0 0 0 0 5.5311 0 Q53FP2 NACHO_HUMAN Novel acetylcholine receptor chaperone TMEM35A NACHO TMEM35 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of protein localization to cell surface [GO:2000010] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778] acetylcholine receptor regulator activity [GO:0030548] DAYSEMKR 1 4.8 0.84049 -0.043952 0 0 0 0 0 8.44361 0 0 0 0 0 0 Q53FV1 ORML2_HUMAN ORM1-like protein 2 (Adoplin-2) ORMDL2 HSPC160 MSTP095 Homo sapiens (Human) ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] ARLLTHWEQMDYGLQFTSSR 1 13.1 0.8184 -0.01737 0 0 0 7.80407 0 0 0 0 0 0 0 0 Q53FZ2 ACSM3_HUMAN "Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Propionate--CoA ligase) (EC 6.2.1.17) (Protein SA homolog)" ACSM3 SAH Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; regulation of blood pressure [GO:0008217] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 2-methylbutanoate-CoA ligase activity [GO:0043759]; ATP binding [GO:0005524]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872]; propionate CoA-transferase activity [GO:0018729]; propionate-CoA ligase activity [GO:0050218] ANCIITNDVLAPAVDAVASK 1 3.4 0.87261 -0.10928 0 0 0 0 0 0 0 0 0 0 0 13.5095 Q53G44 IF44L_HUMAN Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) defense response to virus [GO:0051607]; immune response [GO:0006955] cytoplasm [GO:0005737] YRIYSVKDGK 1 2.2 0.61776 0.17394 0 0 0 0 0 0 0 10.3196 0 0 0 0 Q53GD3 CTL4_HUMAN Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1) SLC44A4 C6orf29 CTL4 NG22 TPPT1 UNQ441/PRO874 Homo sapiens (Human) acetylcholine biosynthetic process [GO:0008292]; acetylcholine secretion [GO:0061526]; choline transport [GO:0015871]; neuromast hair cell development [GO:0035675]; otolith formation [GO:0032475]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cell growth [GO:0030307]; thiamine pyrophosphate transmembrane transport [GO:0030974]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422] GPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPR;NNGSLDRPYYMSK 2 7.2 0.82886 -0.023015 0 0 0 0 0 8.10743 0 0 0 0 7.92505 10.561 Q53GI3 ZN394_HUMAN Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14) ZNF394 ZKSCAN14 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDPARRDFCR 1 1.8 0.97416 -1.4211 0 0 0 0 0 0 0 0 10.1563 0 0 0 Q53GL0 PKHO1_HUMAN Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) PLEKHO1 CKIP1 OC120 HQ0024c Homo sapiens (Human) lamellipodium morphogenesis [GO:0072673]; myoblast fusion [GO:0007520]; myoblast migration [GO:0051451]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] cytoplasm [GO:0005737]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] GATYTPQAPKKLTPTEK;LTPTEKGR;LTPTEKGRCASLEEILSQR;SPPDSESEQLLLETER 4 11.2 0.96101 -1.063 0 0 11.5551 0 0 0 0 0 9.01625 6.88387 0 0 Q53GL7 PAR10_HUMAN Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) PARP10 Homo sapiens (Human) chromatin organization [GO:0006325]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; translesion synthesis [GO:0019985]; viral protein processing [GO:0019082] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714] AQLVVHSAFEQDVEELDRALR;ASLSVQDR;AVFVARVLTGDYGQGR;SLLGSISCHVLCLEHPGSAR;TLPAELRAR 5 7.2 0.95533 -0.83002 12.4983 0 0 0 11.2048 9.35176 0 10.0988 11.655 0 0 0 Q53GS7 GLE1_HUMAN mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) GLE1 GLE1L Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phospholipid binding [GO:0005543]; translation initiation factor binding [GO:0031369] EAEQQRVK;LKQFLEKCLQHK;MLGYQVKDSK;QEIHPHGLNHGWR;VEGCVRMYELVHR;VEQQDNFLK 6 9.3 0.97393 -3.0349 0 0 0 11.1898 7.88649 10.0906 0 0 14.0229 0 0 11.8496 Q53GS9 UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) USP39 CGI-21 HSPC332 PRO2855 Homo sapiens (Human) "cell division [GO:0051301]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540] hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] EAPASVVPFVR 1 1.9 0.91665 -0.41098 0 0 12.4217 0 0 0 0 0 0 0 0 0 Q53H12 AGK_HUMAN "Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)" AGK MULK Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; lipid phosphorylation [GO:0046834]; protein insertion into mitochondrial inner membrane [GO:0045039] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] acylglycerol kinase activity [GO:0047620]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729] ARTLFEK;TVFFKTLRNHWK;WGSFRDAGVK 3 6.9 0.98044 -1.796 0 0 0 9.75255 0 0 0 9.2801 0 0 0 0 Q53H47 SETMR_HUMAN Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] SETMAR Homo sapiens (Human) cell population proliferation [GO:0008283]; DNA catabolic process [GO:0006308]; DNA double-strand break processing [GO:0000729]; DNA integration [GO:0015074]; double-strand break repair via nonhomologous end joining [GO:0006303]; methylation [GO:0032259]; mitotic DNA integrity checkpoint signaling [GO:0044774]; negative regulation of chromosome organization [GO:2001251]; nucleic acid metabolic process [GO:0090304]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; replication fork processing [GO:0031297] nucleolus [GO:0005730]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; zinc ion binding [GO:0008270] IDSMVPK;IVTCDEKWILYDNRR 2 3.2 0.97575 -1.4709 0 8.75195 0 0 0 10.3357 0 0 0 0 0 0 Q53H76 PLA1A_HUMAN Phospholipase A1 member A (EC 3.1.1.111) (Phosphatidylserine-specific phospholipase A1) (PS-PLA1) PLA1A NMD PSPLA1 Homo sapiens (Human) lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phosphatidylserine metabolic process [GO:0006658] acrosomal membrane [GO:0002080]; extracellular region [GO:0005576]; extracellular space [GO:0005615] phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970] FKFQSSNRVWK;IGLVEQGGVKIEPLPK;KDRTTIIGK;NVIKLSLEISLFLNK 4 11.2 0.97391 -1.4017 0 5.21704 0 0 0 0 9.30157 0 8.0954 0 0 0 Q53H80 AKIR2_HUMAN Akirin-2 AKIRIN2 C6orf166 Homo sapiens (Human) adaptive immune response [GO:0002250]; cerebral cortex development [GO:0021987]; defense response to bacterium [GO:0042742]; embryo development ending in birth or egg hatching [GO:0009792]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]; regulation of muscle cell differentiation [GO:0051147]; response to lipopolysaccharide [GO:0032496] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coregulator activity [GO:0003712] EQPLFTLRQVGMICER;TLDFDPLLSPASPKR 2 15.3 0.67202 0.1673 0 0 0 9.36979 0 0 0 8.32386 0 0 0 0 Q53H82 LACB2_HUMAN Endoribonuclease LACTB2 (EC 3.1.27.-) (Beta-lactamase-like protein 2) LACTB2 CGI-83 Homo sapiens (Human) mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] ENFEKSFTVMELVKIIYK;EQQILTLFR;VERLSNR 3 11.8 0.97253 -2.838 8.00135 7.20124 0 0 9.04587 0 10.9732 0 0 0 0 0 Q53H96 P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) PYCR3 PYCRL Homo sapiens (Human) L-proline biosynthetic process [GO:0055129] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686] identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735] AAAEPSPR;VLRVLPNLPCVVQEGAIVMAR 2 10.6 0.91473 -0.33664 9.07235 0 9.00239 0 0 0 0 0 0 0 0 0 Q53HC5 KLH26_HUMAN Kelch-like protein 26 KLHL26 Homo sapiens (Human) LQSCAEIDLFR 1 1.8 0.81435 -0.0060313 0 0 0 0 0 0 0 0 0 8.82753 0 0 Q53HC9 EIPR1_HUMAN EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) EIPR1 TSSC1 Homo sapiens (Human) "endocytic recycling [GO:0032456]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; protein ubiquitination [GO:0016567]; regulation of insulin secretion [GO:0050796]" trans-Golgi network [GO:0005802] VLTCAAVWRMPK 1 3.1 0.98058 -1.5985 0 0 0 0 0 9.59584 0 0 0 0 0 0 Q53HI1 UNC50_HUMAN Protein unc-50 homolog (Periodontal ligament-specific protein 22) (PDLs22) (Protein GMH1 homolog) (hGMH1) (Uncoordinated-like protein) UNC50 UNCL HSD-23 HSD23 Homo sapiens (Human) protein localization to cell surface [GO:0034394] Golgi membrane [GO:0000139]; nuclear inner membrane [GO:0005637] RNA binding [GO:0003723] HTAGAKR 1 2.7 0.93348 -0.50841 0 0 0 0 0 0 0 0 0 9.90132 0 0 Q53HV7 SMUG1_HUMAN Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-) SMUG1 Homo sapiens (Human) base-excision repair [GO:0006284]; depyrimidination [GO:0045008] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; identical protein binding [GO:0042802]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065]; uracil DNA N-glycosylase activity [GO:0004844] IQCDRVQVR 1 5.1 0.97552 -1.4542 0 0 0 0 0 0 10.5977 0 0 0 0 0 Q53QZ3 RHG15_HUMAN Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) ARHGAP15 BM-024 BM-030 BM-046 Homo sapiens (Human) regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] IEFYKESK;LSQSKSMILTDVGKVTEPISR;SLMFRLHHSASDTSDK 3 9.5 0.98014 -1.5996 0 0 8.29659 0 0 0 0 0 0 0 8.41697 0 Q53R41 FAKD1_HUMAN "FAST kinase domain-containing protein 1, mitochondrial" FASTKD1 KIAA1800 Homo sapiens (Human) mitochondrial RNA metabolic process [GO:0000959]; mitochondrial RNA processing [GO:0000963]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] AICPFSWRVFQFRPISCEPLIIQMNK;HFQQQLVNK;ITQELTFLHFQR;LFVALGPIAGPEEKK 4 7.3 0.91049 -0.28858 0 0 10.1013 0 9.01567 2.61438 0 0 0 15.0749 14.9105 6.60183 Q53RT3 APRV1_HUMAN Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein) (TAPS) ASPRV1 SASP Homo sapiens (Human) protein processing [GO:0016485]; skin development [GO:0043588] membrane [GO:0016020] aspartic-type endopeptidase activity [GO:0004190] ILGVWDTAVSLGKLKLK 1 5 0.86413 -0.087737 0 0 0 7.35957 0 0 0 0 0 0 0 0 Q53RY4 KCP3_HUMAN Keratinocyte-associated protein 3 (KCP-3) KRTCAP3 KCP3 UNQ3066/PRO9898 Homo sapiens (Human) membrane [GO:0016020] RRCSLCAFDAAR;VGLALILVGHVNLLLGAVLHGTVLR 2 15.4 0.8645 -0.089697 4.20438 0 5.00859 0 0 4.29072 0 0 0 0 0 0 Q53RY4 KCP3_HUMAN Keratinocyte-associated protein 3 (KCP-3) KRTCAP3 KCP3 UNQ3066/PRO9898 Homo sapiens (Human) membrane [GO:0016020] MRVGLALILVGHVNLLLGAVLHGTVLR;VGLALILVGHVNLLLGAVLHGTVLR 2 12.2 0.83995 -0.045996 0 0 0 0 0 0 0 6.27094 0 0 0 0 Q53S58 TM177_HUMAN Transmembrane protein 177 TMEM177 Homo sapiens (Human) mitochondrial respiratory chain complex II assembly [GO:0034553] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ASLTLSR;ASLTLSREAQK;LLSGNLALR;SLLGKDGEKLYTPSGNIVPR 4 12.9 0.87378 -0.11923 0 0 10.6279 0 0 0 10.7194 0 11.6224 5.2235 0 0 Q53SF7 COBL1_HUMAN Cordon-bleu protein-like 1 COBLL1 KIAA0977 Homo sapiens (Human) extracellular exosome [GO:0070062] actin monomer binding [GO:0003785]; cadherin binding [GO:0045296] AGSLQLSSMSAGNSSLR;EKENKGFFSFFQR;ELTNKEAER;SNTISKPYISNTLPSDAPK 4 5.1 0.97473 -3.1159 0 0 0 11.1113 0 0 0 9.45354 10.1406 0 0 0 Q53SZ7 PRR30_HUMAN Proline-rich protein 30 PRR30 C2orf53 Homo sapiens (Human) LPQGQAR 1 1.7 0.94017 -0.58436 0 0 0 0 0 0 0 0 8.30424 6.94334 0 0 Q53T59 H1BP3_HUMAN HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) HS1BP3 Homo sapiens (Human) regulation of apoptotic process [GO:0042981] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] phosphatidylinositol binding [GO:0035091] AVFNEILR;RAVFNEILRCVSK 2 3.3 0.92901 -0.4843 0 0 0 0 11.1311 0 0 10.71 0 0 0 0 Q53T94 TAF1B_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) TAF1B Homo sapiens (Human) DNA-templated transcription [GO:0006351]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668] metal ion binding [GO:0046872]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; TBP-class protein binding [GO:0017025] KREMVVNLQK;YLWKSEKPLYYSFVDKPVAYKK 2 5.3 0.74567 0.088303 0 0 0 9.8822 9.98911 4.44434 7.95931 0 0 10.7188 0 10.8622 Q53TN4 CYBR1_HUMAN Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) CYBRD1 DCYTB FRRS3 Homo sapiens (Human) ascorbate homeostasis [GO:0140576]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; reductive iron assimilation [GO:0033215]; response to iron ion [GO:0010039] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575]" LDEGEAIIVYRLPWTWK;NLALDEAGQR 2 11.8 0.92908 -0.46178 0 0 0 0 0 0 0 0 0 0 11.9941 0 Q53TQ3 IN80D_HUMAN INO80 complex subunit D INO80D Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] HASDDDDAESR;HQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGAR;KMDNFLRGDNSR;LAQNRQR;VTQLCTYFQQKYKHLCR 5 7.9 0.97662 -1.4888 5.09778 9.38079 0 3.31878 3.21892 0 7.16128 8.59984 8.35125 0 10.4049 6.58299 Q53TS8 CTSRT_HUMAN Cation channel sperm-associated targeting subunit tau (CatSper-tau) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein) (C2 calcium-dependent domain-containing protein 6) C2CD6 ALS2CR11 CATSPERT Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]; vesicle-mediated transport to the plasma membrane [GO:0098876] CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] KYFPLQNLK;LRSFLKEILQNYFLK;NCRHFMPK;NGQRLCK;NIFNVFFKYNHSER;NIPEYSLSEGGQIIK;QIQHYLVERLSESGHITK;SLDRKEHVNIYK 8 5.4 0.97305 -2.5913 0 12.4032 13.1925 0 0 0 5.99564 8.59033 0 5.68908 6.96012 0 Q562E7 WDR81_HUMAN WD repeat-containing protein 81 WDR81 Homo sapiens (Human) aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] AQGSGGR;ISNFHYLMQLNRLAGR;LQGKEAVKEK;VEVHGLRKR 4 2.2 0.97549 -2.3493 9.26973 0 0 7.13853 0 7.38275 0 0 11.6237 0 0 0 Q562E7 WDR81_HUMAN WD repeat-containing protein 81 WDR81 Homo sapiens (Human) aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] VRWLSAKLGPTVASR 1 2.1 0.85107 -0.074157 0 0 0 0 7.58489 0 0 0 0 0 0 0 Q562F6 SGO2_HUMAN Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) SGO2 SGOL2 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic cohesin complex [GO:0030892]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]" CTPFYFKEPSLR;CTPFYFKEPSLRDK;DNFFSLTPK;ELQIPALSTR;NKPDFYTKAFR;SAEQNESK;SIEYTVK 7 4.7 0.97659 -2.1747 0 0 11.2678 10.4983 8.85922 0 8.25984 0 0 0 9.65828 0 Q562R1 ACTBL_HUMAN Beta-actin-like protein 2 (Kappa-actin) ACTBL2 Homo sapiens (Human) axonogenesis [GO:0007409]; cell motility [GO:0048870] actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267] ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] DLTDYLMK;HQGVMVGMGQK;IIAPPER;IIAPPERK;IKIIAPPER;LDLAGRDLTDYLMK;SYELPDGQVITIGNER;VAPDEHPILLTEAPLNPK 8 18.4 0 4.6671 11.1355 0 17.5327 0 0 11.1578 9.46807 0 0 0 0 13.3706 Q567U6 CCD93_HUMAN Coiled-coil domain-containing protein 93 CCDC93 Homo sapiens (Human) endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231] DQLNDQYLELLEKQR 1 2.4 0.81675 -0.016925 0 0 8.44497 0 0 0 0 0 0 0 0 0 Q569H4 LARGN_HUMAN Protein Largen (Mesenchymal stem cell protein DSC54) (Proline-rich protein 16) PRR16 Homo sapiens (Human) positive regulation of cell size [GO:0045793]; positive regulation of translation [GO:0045727] CPQAGPR 1 3 0.90914 -0.31302 0 6.44087 8.87738 0 0 0 0 0 0 0 0 0 Q569K4 Z385B_HUMAN Zinc finger protein 385B (Zinc finger protein 533) ZNF385B ZNF533 Homo sapiens (Human) intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332] nucleus [GO:0005634] nucleic acid binding [GO:0003676]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270] LLYCSLCK;MQNGSKGSGLQNK;VKALDATK 3 6.2 0.97832 -2.1497 0 0 0 0 9.40657 0 0 10.0656 0 10.1664 0 0 Q569K6 CC157_HUMAN Coiled-coil domain-containing protein 157 CCDC157 KIAA1656 Homo sapiens (Human) AQLEEAEGQK;GQASSAHQPQERPM;QVQSNDIR;VDSMVRHQESLQAKQR 4 6.4 0.91834 -0.40418 0 0 0 0 4.27635 9.01444 8.71812 5.88516 5.34273 0 0 0 Q56NI9 ESCO2_HUMAN N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) ESCO2 Homo sapiens (Human) chromosome segregation [GO:0007059]; double-strand break repair [GO:0006302]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic sister chromatid cohesion [GO:0007064]; post-translational protein acetylation [GO:0034421]; protein localization to chromatin [GO:0071168]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] cell junction [GO:0030054]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; XY body [GO:0001741] "acetyltransferase activity [GO:0016407]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]" RSLGEEQFSVGSVNFMK 1 2.8 0.78521 0.018147 0 0 0 0 0 0 10.8731 0 0 0 0 0 Q56P03 EAPP_HUMAN E2F-associated phosphoprotein (EAPP) EAPP C14orf11 BM-036 Homo sapiens (Human) negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AETDVEEIYHPVMCTECSTEVAVYDK;TQYRAMFVMNCSINKEEVLR;VATAPTR;YKASENR 4 21.1 0.77431 0.0479 0 0 0 10.313 0 4.81803 7.55888 0 0 9.6667 0 11.0393 Q56P42 PYDC2_HUMAN Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2) PYDC2 POP2 Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ELQTVPQTEVDKANGK 1 16.5 0.9159 -0.43111 0 0 0 0 0 0 0 0 0 7.82902 0 0 Q56UN5 M3K19_HUMAN "Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)" MAP3K19 RCK YSK4 Homo sapiens (Human) MAPK cascade [GO:0000165] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IFSENSLK;MANETDPENLNLVLRWR 2 1.9 0.95138 -0.69128 7.49937 0 0 0 0 0 0 0 0 0 0 0 Q587I9 SFT2C_HUMAN Vesicle transport protein SFT2C (SFT2 domain-containing protein 3) SFT2D3 Homo sapiens (Human) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] QLQEYLAQGK 1 4.7 0.89854 -0.23315 0 0 0 0 0 0 0 0 9.7622 0 0 0 Q587J7 TDR12_HUMAN Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) TDRD12 ECAT8 Homo sapiens (Human) fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] PET complex [GO:1990923] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] FSLYCTKPVTLHIDFCR;ICPDRHR 2 2 0.97962 -1.5375 0 0 0 0 9.64024 0 0 0 0 0 0 0 Q58A45 PAN3_HUMAN PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) PAN3 Homo sapiens (Human) deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; protein targeting [GO:0006605] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; protein kinase activity [GO:0004672] KTPNPTASEFIPK 1 1.6 0.64626 0.17078 0 0 0 0 0 0 0 0 0 0 0 10.5118 Q58DX5 NADL2_HUMAN Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2) NAALADL2 Homo sapiens (Human) response to bacterium [GO:0009617] membrane [GO:0016020]; nucleoplasm [GO:0005654] KDSSQDLLYSYAAYSAKGTLK;SNLTSLLVQPISAPLVAKLISSPK 2 5.7 0.71224 0.15211 8.42589 0 0 0 0 0 0 0 0 0 4.08117 0 Q58EX2 SDK2_HUMAN Protein sidekick-2 SDK2 KIAA1514 Homo sapiens (Human) camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; synapse [GO:0045202] AARAQDDVSPYFK;AGVQKEGENR;AQDDVSPYFKTEPVR;DLAEGVTYR;ITKPPQDQSVIK;LSVKNSFCRK;LVLTCMAEGSWPLEFKWLHNNR;VKDLAEGVTYRFR;WGLLIWTLLALHQIR 9 4.5 0.97502 -4.1397 11.1885 10.0845 10.0934 6.81596 0 8.80258 0 10.6095 0 0 10.9104 0 Q58EX7 PKHG4_HUMAN Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LLEAGKEGWAR 1 5.7 0.88222 -0.17989 0 0 0 0 0 0 0 0 0 0 8.96414 0 Q58F21 BRDT_HUMAN Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein) BRDT Homo sapiens (Human) chromatin remodeling [GO:0006338]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; mRNA processing [GO:0006397]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713] DIKIKNADSWK;ENTNEASSEGNSSDDSEDER;LENKYYAK 3 4.1 0.97538 -1.4321 0 0 0 10.2687 0 0 0 0 0 0 11.0324 4.54442 Q58FF6 H90B4_HUMAN Putative heat shock protein HSP 90-beta 4 HSP90AB4P Homo sapiens (Human) cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] EDQTEYLEER;EGLELPEDEEEK;IMEESNVK;LMKEILDK;YESLTDPSK 5 9.3 0.91353 -0.39033 0 0 0 0 11.1854 10.1245 0 0 0 0 0 0 Q58FF7 H90B3_HUMAN Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) HSP90AB3P HSP90BC Homo sapiens (Human) cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] APFDLFENK;DNSTMGYMMAK;EDQTEYLEER;EGLELPEDEEEK;ELKIDIIPNPQER;EMLQQSK;EQDKEISDDEAEEEK;EQVANSAFVER;IDIIPNPQER;LMKEILDK;RAPFDLFENK;SLVSVTK;TLALVDTGIGMTKADLINNLR;VILHLKEDQTEYLEERR;YESLTDPSK;YESLTDPSKLDSGK 16 24.5 0.92712 -0.456 0 0 0 0 10.61 0 0 4.29528 0 0 0 0 Q58FF8 H90B2_HUMAN Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) HSP90AB2P HSP90BB Homo sapiens (Human) cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] ADLINNLGTIAK;MPEEVHLGEK;SIYYITGESK;SLVSVTK;TKPIWTR;YESLTDPSK;YESLTDPSKLDSGK;YIDQEELNK 8 18.1 0.91502 -0.37874 11.9108 0 0 0 0 0 0 0 0 0 0 0 Q58FG1 HS904_HUMAN Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) HSP90AA4P HSP90AD HSPCAL2 Homo sapiens (Human) cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] AQALRDNSTTGYMAAK;EPHISLIPNK;TLVSVTK 3 7.9 0.96312 -1.0865 0 0 0 0 0 0 0 0 5.979 4.38384 0 0 Q58WW2 DCAF6_HUMAN DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 MSTP055 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374] EANFWGANFVMSGSDCGHIFIWDR;ELKTPSAEERR;SEGSGQENENEDEE;SLGLEDPSR 4 6.7 0.97612 -1.4696 0 0 9.23007 0 5.85202 0 0 0 0 7.4154 6.32312 5.86327 Q59H18 TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) TNNI3K CARK Homo sapiens (Human) bundle of His cell to Purkinje myocyte communication [GO:0086069]; peptidyl-serine autophosphorylation [GO:0036289]; protein phosphorylation [GO:0006468]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LEDDLQIK 1 1 0.9131 -0.39033 11.8353 0 0 0 0 0 0 0 0 0 10.1211 0 Q5BJD5 TM41B_HUMAN Transmembrane protein 41B (Protein stasimon) TMEM41B KIAA0033 Homo sapiens (Human) autophagosome assembly [GO:0000045]; intracellular lipid transport [GO:0032365]; modulation by host of viral RNA genome replication [GO:0044830]; nervous system development [GO:0007399] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] phospholipid scramblase activity [GO:0017128] ALGKVLSKYK;GLAAPGSR 2 6.2 0.91694 -0.42864 0 0 0 0 0 0 0 0 0 6.17321 0 0 Q5BJE1 CC178_HUMAN Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) ciliary basal body [GO:0036064] EEEVTEAIRETK;EHSVMLNNIIDQK;FKGREEFLK;IFEEDQRFR;INELNEELK;REHAQTVFDHYMQEK;SLDKEHSVMLNNIIDQK;SLETDRADAEEALK;TLDALIETESK;TLQDTQLCQLQRR;TNESIRKK;TVSSSSTR 12 15.3 0.97816 -7.0224 0 0 9.72567 10.9157 12.567 0 0 10.1255 11.1807 5.80772 6.95303 6.01221 Q5BJE1 CC178_HUMAN Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) ciliary basal body [GO:0036064] EEEVTEAIRETK;EHSVMLNNIIDQK;FKGREEFLK;IFEEDQRFR;ILAVQNQYDLEK;INELNEELK;REHAQTVFDHYMQEK;SLDKEHSVMLNNIIDQK;SLETDRADAEEALK;TLDALIETESK;TNESIRKK;TVSSSSTR 12 14.6 0.80427 0.013059 0 8.5359 0 0 0 0 0 0 0 0 0 0 Q5BJF2 SGMR2_HUMAN Sigma intracellular receptor 2 (S2R) (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (MAC30) (Transmembrane protein 97) TMEM97 MAC30 S2R Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; positive regulation of lipoprotein transport [GO:0140077]; positive regulation of wound healing [GO:0090303]; regulation of cell growth [GO:0001558]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of intracellular lipid transport [GO:0032377] endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867] cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142] DPLLQEPPAWFK;ELYPVEFRNLLKWYAK;GAPATRR 3 19.9 0.93591 -0.53743 0 0 0 0 8.42777 0 0 0 0 0 10.1191 0 Q5BJF6 ODFP2_HUMAN Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 Homo sapiens (Human) cell differentiation [GO:0030154]; centriole-centriole cohesion [GO:0010457]; cilium organization [GO:0044782]; protein localization [GO:0008104]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; spindle pole [GO:0000922] small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198] DLLREQHCK;EEAIHQSQLRLEEK;HQASQKENK;LLLLLQDK;MQKGERQMAK;NIDLTAIISDLRSR;YQSRLQDLKDR 7 9 0.97538 -4.2505 0 0 11.7085 11.2379 9.83856 0 0 8.85284 0 0 5.36359 8.75782 Q5BKT4 AG10A_HUMAN "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-A) (Asparagine-linked glycosylation protein 10 homolog A)" ALG10 ALG10A Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]" TFLSLVWKR 1 1.9 0.92944 -0.47442 0 0 0 0 0 0 0 0 0 0 0 8.78447 Q5BKU9 OXLD1_HUMAN Oxidoreductase-like domain-containing protein 1 OXLD1 C17orf90 Homo sapiens (Human) mitochondrion [GO:0005739] LLQHFQDGGER 1 7.5 0.8978 -0.23345 0 0 0 0 0 0 0 10.5119 0 0 0 0 Q5BKX5 ACTMP_HUMAN Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) ACTMAP C19orf54 Homo sapiens (Human) protein processing [GO:0016485] cytoplasm [GO:0005737] cysteine-type aminopeptidase activity [GO:0070005]; initiator methionyl aminopeptidase activity [GO:0004239] AGPVPKGREDVK 1 3.4 0.86976 -0.094471 0 0 0 0 0 0 0 0 0 7.91874 0 0 Q5BKX6 S45A4_HUMAN Solute carrier family 45 member 4 SLC45A4 KIAA1126 Homo sapiens (Human) sucrose transport [GO:0015770] membrane [GO:0016020] sucrose:proton symporter activity [GO:0008506] EGLQGPVETERLQVLTSVRSR;VPNGSGSPTKDALGGYTR 2 4.9 0.93649 -0.52507 0 11.6299 0 3.81619 0 0 0 0 0 0 0 0 Q5BKX8 CAVN4_HUMAN Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) CAVIN4 MURC Homo sapiens (Human) cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] DRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSAR;TVAEGEECAR 2 12.9 0.83698 -0.034809 0 11.0104 0 0 0 3.18217 0 0 0 0 9.96795 0 Q5BKZ1 ZN326_HUMAN DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) ZNF326 ZIRD Homo sapiens (Human) mRNA processing [GO:0006397]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] IEARREK;MDFEDDYTHSACR;RESVLTATSILNNPIVK;VVMEFLHECMVNK 4 8.6 0.98002 -1.5607 0 6.48517 13.0505 6.86641 8.56932 3.87017 0 0 8.85225 0 0 0 Q5C9Z4 NOM1_HUMAN Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) NOM1 C7orf3 Homo sapiens (Human) hair follicle maturation [GO:0048820]; ribosomal small subunit biogenesis [GO:0042274] nucleolus [GO:0005730] RNA binding [GO:0003723] ADLATKCLQGK;EIIHVLMDCCLQEK;SLCGSGEK 3 3.8 0.9796 -1.8787 0 0 0 0 0 0 0 0 9.18785 0 10.7006 8.302 Q5CZ79 AN20B_HUMAN Ankyrin repeat domain-containing protein 20B (Ankyrin repeat domain-containing protein 20A pseudogene) ANKRD20A8P ANKRD20B Homo sapiens (Human) DFHNHEETKGLMDENCILK;KGNNTNKSEK;LFGFGSR;QLEPTVQSLEMK 4 5.8 0.91506 -0.37972 0 0 9.53469 7.23314 0 0 0 0 0 0 0 0 Q5CZC0 FSIP2_HUMAN Fibrous sheath-interacting protein 2 FSIP2 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288] sperm end piece [GO:0097229]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] DADKKGCSFLSK;DNPKPCFK;EIMKPFFISK;EIQSSFIK;FITIFER;GGYITSNNKVVCTLR;IEVKLKEPHISPIAPIIR;IVPHVGKKPVKIDPK;KEEKNLVTEPTHYFIHR;KPVKIDPKIISEHLAVISIK;LFDKWQTESNDK;LLEEVLALFLAKLIR;LSYDQSPPGDNVLNVIQEISR;NPTSARLPLTFCDTFPK;RPDSETMPSCSTRNKVQDHRPR;SLHDPHLKAYYK;SPQREEVK;SQEQIPNHWFTK;SYDSNSLTVSLNNPSVVSSK;TAKAMDEMKNLK;TGFVFCSDEDMK;TIVDMVYSK;VSSDLPTSVR;VTSTTTVKSK 24 4.5 0.97872 -11.564 0 9.79742 4.18824 10.0898 10.3515 10.0338 12.1192 0 12.6172 12.0868 12.0383 8.13648 Q5D0E6 DALD3_HUMAN DALR anticodon-binding domain-containing protein 3 DALRD3 Homo sapiens (Human) arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] LDLLWQK;SRDFLAPHRALQAR 2 3.9 0.91741 -0.40055 2.47449 0 0 0 0 0 0 0 0 11.3927 0 0 Q5D1E8 ZC12A_HUMAN Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) ZC3H12A MCPIP MCPIP1 Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response-activating signaling pathway [GO:0002757]; inflammatory response [GO:0006954]; miRNA catabolic process [GO:0010587]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum membrane [GO:0030867] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613] LGVQADTNTVLGELVKHGTATER 1 3.8 0.8822 -0.1646 0 0 0 0 10.2884 0 0 0 0 0 0 0 Q5D862 FILA2_HUMAN Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin) FLG2 IFPS Homo sapiens (Human) cell adhesion [GO:0007155]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914] ENGQPQNCGGQWR;RRQGTTHGQR;SSQSENSDSEVHSK 3 1.5 0.97895 -2.051 11.5061 0 0 0 0 0 0 0 3.96246 0 11.4427 0 Q5DID0 UROL1_HUMAN Uromodulin-like 1 (Olfactorin) UMODL1 Homo sapiens (Human) adipose tissue development [GO:0060612]; cellular response to gonadotropin-releasing hormone [GO:0097211]; regulation of gene expression [GO:0010468]; regulation of granulosa cell apoptotic process [GO:1904708]; regulation of ovarian follicle development [GO:2000354]; regulation of reproductive process [GO:2000241]; single fertilization [GO:0007338] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; peptidase inhibitor activity [GO:0030414] EDDCVPGTSCR;GLSLLGYQLCSHR;IVNHNLTEK 3 2.5 0.93671 -0.54475 0 7.71425 0 0 0 0 6.57731 0 0 0 0 9.28295 Q5EB52 MEST_HUMAN Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) MEST PEG1 Homo sapiens (Human) mesoderm development [GO:0007498] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062] hydrolase activity [GO:0016787] LLKDGGVLSPILTRLMNFFVFSR;LMNFFVFSR 2 6.9 0.87897 -0.14145 0 0 0 0 7.22352 8.21004 0 0 0 0 0 9.02937 Q5EBL2 ZN628_HUMAN Zinc finger protein 628 ZNF628 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPDCPKAFKGSSALLYHQR;TVAGLSR 2 2.5 0.8753 -0.12168 9.18614 0 0 0 7.91295 0 8.99084 0 0 4.07099 0 0 Q5EBL4 RIPL1_HUMAN RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) RILPL1 RLP1 Homo sapiens (Human) cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; nitric oxide mediated signal transduction [GO:0007263]; protein transport from ciliary membrane to plasma membrane [GO:1903445] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] HEGMSER;TSPQPESGIK 2 4.2 0.93656 -0.54414 0 0 0 0 0 0 0 9.80116 0 0 6.54387 0 Q5EBM0 CMPK2_HUMAN "UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6)" CMPK2 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] (d)CMP kinase activity [GO:0004127]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]; UMP kinase activity [GO:0033862] GPFQRCQLLR;SPPSCIGQWR 2 4.5 0.80386 0.012811 7.15987 0 3.71359 7.17253 7.72819 7.35041 7.63938 0 9.72663 12.0792 11.873 11.337 Q5EBM4 ZN542_HUMAN Putative zinc finger protein 542 (Zinc finger protein 542 pseudogene) ZNF542P ZNF542 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] LPWIMAKEEIRGPLPDVPGAEIK 1 15.8 0.59607 0.17852 0 0 0 0 0 0 0 0 0 0 0 4.8023 Q5EE01 CENPW_HUMAN Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein) CENPW C6orf173 CUG2 Homo sapiens (Human) cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278] "chromosome, centromeric region [GO:0000775]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] KKPQLRLEK;VINKEHVLAAAKVILK 2 28.4 0.87412 -0.10534 0 0 0 0 0 0 0 0 0 5.23856 8.56731 0 Q5F1R6 DJC21_HUMAN DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) DNAJC21 DNAJA5 Homo sapiens (Human) protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; ribosome [GO:0005840] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AMEKENK;DGESEHK;DSDEAEDAELYDDLYCPACDK;DSYLPAAHFQMAWGKK 4 8.9 0.98091 -2.0221 3.92495 9.78067 8.73759 0 0 0 0 4.10241 0 5.29906 12.0585 0 Q5FBB7 SGO1_HUMAN Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) SGO1 SGOL1 Homo sapiens (Human) "attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; centriole-centriole cohesion [GO:0010457]; chromosome segregation [GO:0007059]; meiotic chromosome segregation [GO:0045132]; mitotic sister chromatid cohesion, centromeric [GO:0071962]" "centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]" kinase binding [GO:0019900] NKASPAVALPKR;TVSVRSSLK 2 3.7 0.98085 -1.7919 0 4.49346 0 0 0 9.12766 3.86156 0 0 0 0 11.3356 Q5FVE4 ACBG2_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Arachidonate--CoA ligase ACSBG2) (EC 6.2.1.15) (Bubblegum-related protein) (PRTD-NY3) ACSBG2 BGR UNQ2443/PRO5005 Homo sapiens (Human) cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] DFSIYGGELGPMMK;ILTGCKNMLFQQNKDGIGEICLWGR;LLSCGKILTGCK;TIPEFFR 4 8.4 0.9765 -2.273 0 0 0 0 0 0 0 0 5.32833 10.9338 0 7.78169 Q5FWF4 ZRAB3_HUMAN DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] ZRANB3 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA rewinding [GO:0036292]; negative regulation of DNA recombination [GO:0045910]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; response to UV [GO:0009411] nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA endonuclease activity [GO:0004520]; helicase activity [GO:0004386]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] MTSCDESK 1 1.3 0.93995 -0.57955 0 0 9.88513 6.29715 0 0 0 0 0 0 0 0 Q5FWF5 ESCO1_HUMAN N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) ESCO1 EFO1 KIAA1911 Homo sapiens (Human) mitotic sister chromatid cohesion [GO:0007064]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270] IIMVLPEDPKYALK;IWVFSMMR;KLVHENPKANEQLNR;KVEHQTACACSSQCTQGSEK;SQRLQQLTEVSR;TDEKQLIIDAGQK;VEHQTACACSSQCTQGSEK 7 9.8 0.97508 -3.2753 9.51335 0 0 0 0 10.3136 8.5988 0 0 11.1592 11.3348 0 Q5FWF5 ESCO1_HUMAN N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) ESCO1 EFO1 KIAA1911 Homo sapiens (Human) mitotic sister chromatid cohesion [GO:0007064]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270] FLEGLEERK;KLVHENPKANEQLNR;KVEHQTACACSSQCTQGSEK;SQRLQQLTEVSR;TDEKQLIIDAGQK;VEHQTACACSSQCTQGSEK 6 9.8 0.91772 -0.35274 0 0 0 0 10.6089 10.9813 0 0 0 0 0 0 Q5FYA8 ARSH_HUMAN Arylsulfatase H (ASH) (EC 3.1.6.-) ARSH Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] FVGRSKYGR;WHQKDCATVWKAHYVTPK 2 4.8 0.70996 0.15883 0 0 4.22651 0 0 0 0 0 0 4.50627 0 4.43496 Q5FYB1 ARSI_HUMAN Arylsulfatase I (ASI) (EC 3.1.6.-) ARSI Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] YRTMGNVAR 1 1.6 0.98018 -1.5618 0 10.9354 0 0 0 0 0 0 0 0 0 0 Q5GAN3 RNS13_HUMAN Probable inactive ribonuclease-like protein 13 RNASE13 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576] nucleic acid binding [GO:0003676] MQNSDCPK 1 5.1 0.91498 -0.39033 0 0 0 0 0 0 6.66135 0 0 0 0 0 Q5GAN4 RNS12_HUMAN Probable inactive ribonuclease-like protein 12 RNASE12 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576] nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540] VACQNLSAIFCFQSETKFK 1 12.9 0.94588 -0.65118 0 0 10.661 0 0 0 0 0 0 0 0 0 Q5GAN6 RNS10_HUMAN Inactive ribonuclease-like protein 10 RNASE10 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of fertilization [GO:0080154]; single fertilization [GO:0007338] extracellular region [GO:0005576] nucleic acid binding [GO:0003676] DYLRLDQTDRECNDMMAHK 1 8.8 0.51349 0.1876 0 0 0 0 0 0 0 0 0 6.52516 0 0 Q5GFL6 VWA2_HUMAN von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2) VWA2 AMACO Homo sapiens (Human) calcium-independent cell-matrix adhesion [GO:0007161]; regulation of insulin receptor signaling pathway [GO:0046626] basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] CRDGWEGPHCENR;GARPGVPKAVVVLTGGR 2 4 0.92992 -0.46761 0 0 0 0 0 0 0 0 0 12.4802 0 0 Q5GH72 XKR7_HUMAN XK-related protein 7 XKR7 C20orf159 XRG7 Homo sapiens (Human) apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] TEGPVIR;TLRTEGPVIRIDLPR 2 2.6 0.87682 -0.12334 0 0 0 0 0 0 6.25412 9.80774 0 0 0 0 Q5GH76 XKR4_HUMAN "XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]" XKR4 KIAA1889 XRG4 Homo sapiens (Human) apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] AAKSDGRLK;QSGENDR 2 2.5 0.9801 -1.5623 0 0 5.03988 0 0 0 0 0 0 0 0 0 Q5GH77 XKR3_HUMAN XK-related protein 3 (X Kell blood group-related 3) (XTES) XKR3 XRG3 Homo sapiens (Human) plasma membrane [GO:0005886] AALLFWHILLLGPIVRCLHTIR;EIAFSIRDNFMQQK;VGYFSIRK 3 9.6 0.96765 -1.3207 0 0 0 8.5818 0 0 0 0 0 8.926 12.4697 8.6537 Q5GLZ8 HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) HERC4 KIAA1593 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650] ubiquitin protein ligase activity [GO:0061630] EFFLLIMRELLDPK;KQFLLFLTGSDR;KSDFFINK;VLEILHRVNEKMGQIIQYDK 4 5.1 0.98029 -1.8106 9.83346 0 0 0 8.68268 9.66818 0 0 0 0 4.8939 0 Q5GLZ8 HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) HERC4 KIAA1593 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650] ubiquitin protein ligase activity [GO:0061630] KSDFFINK;LLVVTIIHLHFLKQVK;LYRLLVVTIIHLHFLKQVK 3 23.1 0.67647 0.16583 10.0087 0 0 7.053 0 0 0 6.56192 0 7.48607 0 0 Q5H8A4 PIGG_HUMAN GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) PIGG GPI7 UNQ1930/PRO4405 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740]" AAIGSVRFPWRPDSKDISK;LYLEEKHSEVLFNLGSK 2 3.7 0.95705 -0.8488 0 0 0 0 0 0 0 4.22982 0 0 0 0 Q5H8C1 FREM1_HUMAN FRAS1-related extracellular matrix protein 1 (Protein QBRICK) FREM1 C9orf143 C9orf145 C9orf154 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GPSQRSK;GTWNAAAQACR;LFMVDSIPK;NGCYGIYITSR 4 1.7 0.97391 -2.4201 0 0 0 0 10.5877 9.67161 0 0 0 0 0 3.17273 Q5H913 AR13A_HUMAN ADP-ribosylation factor-like protein 13A ARL13A Homo sapiens (Human) non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500] ciliary membrane [GO:0060170]; non-motile cilium [GO:0097730] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LVKENKCPCR;VAGKPILILANKQDKK 2 9 0.96233 -1.0768 0 0 0 0 0 0 0 0 0 0 3.39917 0 Q5H943 KKLC1_HUMAN Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) CT83 CXorf61 KKLC1 Homo sapiens (Human) nucleus [GO:0005634]; plasma membrane [GO:0005886] GASPHRK 1 6.2 0.78086 0.033125 0 0 0 0 0 0 8.0955 0 0 0 0 0 Q5H9B9 BM2KL_HUMAN Putative BMP-2-inducible kinase-like protein BMP2KL Homo sapiens (Human) YSDMSPVYRDK 1 2.7 0.88705 -0.18532 0 0 0 0 0 0 0 0 0 0 0 9.31965 Q5H9E4 S2553_HUMAN Solute carrier family 25 member 53 (Mitochondrial carrier triple repeat protein 6) SLC25A53 MCART6 Homo sapiens (Human) mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] NAD transmembrane transporter activity [GO:0051724] LSLGYYRGFWPVLAR;TRAEAPGKK 2 7.8 0.98086 -1.692 0 0 0 0 0 0 0 0 0 8.53846 0 0 Q5H9F3 BCORL_HUMAN BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1) BCORL1 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] transcription corepressor activity [GO:0003714] HLWRAREMPWR;KLPSDPQESTK;LGHKSEDKPDDPQPK;MKCGKEK;NLLLPNK;SHHAQDK 6 3.2 0.97688 -2.2392 0 0 0 9.63254 0 0 9.09532 0 9.40595 9.18765 10.6675 0 Q5H9I0 TFDP3_HUMAN Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661) TFDP3 DP4 HCA661 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416] FRAASNHASPNESAYDVKNIK 1 5.2 0.95633 -0.99469 0 0 0 0 0 0 8.37369 0 0 0 0 0 Q5H9J9 T11X2_HUMAN T-complex protein 11-like X-linked protein 2 TCP11X2 Homo sapiens (Human) protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490] acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126] SIVDQWIR 1 1.6 0.93503 -0.51682 0 0 0 0 0 0 0 10.6315 0 0 0 0 Q5H9K5 ZMAT1_HUMAN Zinc finger matrin-type protein 1 ZMAT1 KIAA1789 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] GLEPKTCFRK;VQKARGLDPK 2 3.1 0.97336 -2.6409 0 0 0 0 0 0 0 0 0 11.6227 0 0 Q5H9L4 TAF7L_HUMAN Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit) TAF7L TAF2Q Homo sapiens (Human) cell differentiation [GO:0030154]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669] LVDLPCVIESLRTLDKK;QGHTSSVMEIQKQIEKK 2 11.3 0.74044 0.10628 0 0 0 8.41578 0 0 0 0 9.05677 0 0 0 Q5H9M0 PWP3B_HUMAN PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1) PWWP3B MUM1L1 Homo sapiens (Human) extracellular exosome [GO:0070062] EESACVKDEK;ENSACLLASSESDDSLYDDK;ETKQDTFR;GIRVNFRR;LDSTETK 5 7.6 0.97402 -3.0116 5.74451 12.4516 0 12.4064 0 8.51775 10.3696 0 0 0 0 0 Q5H9R4 ARMX4_HUMAN Armadillo repeat-containing X-linked protein 4 ARMCX4 Homo sapiens (Human) membrane [GO:0016020] AESGADTRASAQPQIFAK;AGTGAGTR;EAVTQTDAEAGKIVK;FAHQSEASFPVEDESR 4 2.5 0.94165 -0.60359 11.9959 11.3167 0 0 11.9154 0 12.2157 0 0 13.0657 0 0 Q5H9R4 ARMX4_HUMAN Armadillo repeat-containing X-linked protein 4 ARMCX4 Homo sapiens (Human) membrane [GO:0016020] EAVTQTDAEAGKIVK;MSAAGLK 2 6.3 0.65108 0.17065 0 0 9.14216 0 0 0 0 0 0 0 0 0 Q5H9R7 PP6R3_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 Homo sapiens (Human) regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888] DLPDEVRER;TTWGVLDPPVGNTR 2 2.6 0.89722 -0.23413 0 0 0 0 0 0 0 0 10.6499 0 9.08468 0 Q5H9S7 DCA17_HUMAN DDB1- and CUL4-associated factor 17 DCAF17 C2orf37 Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] VLPFSLVGILEINKK 1 2.9 0.32448 0.24653 0 0 0 0 0 0 0 0 8.86267 0 0 0 Q5H9T9 FSCB_HUMAN Fibrous sheath CABYR-binding protein FSCB C14orf155 Homo sapiens (Human) negative regulation of protein sumoylation [GO:0033234] sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509] LGSVVLEGEAK;SLQTDTIVEEKKEVK 2 3.2 0.90769 -0.30316 12.0176 0 0 0 0 0 11.7009 0 0 0 0 10.9417 Q5H9U9 DDX6L_HUMAN Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.4.13) (DEAD box protein 60-like) DDX60L Homo sapiens (Human) defense response to virus [GO:0051607] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727] DHAVFFREMTQLILNEMPK;FQLQYMGHYLIR;LRCLCVAFQLHLPLSQRACSR;VITCSWIRNSDSFLK 4 3.9 0.90343 -0.26652 0 0 0 0 0 0 0 0 0 0 10.1532 3.24111 Q5HY64 FA47C_HUMAN Putative protein FAM47C FAM47C Homo sapiens (Human) QLPPEAGVSHLCPEPPKTR;TRVSSLPPEPPETGVSHLCPEPPETR;VSCLPPEPPK 3 7.8 0.90946 -0.29666 0 0 10.7963 0 0 0 10.3308 0 0 0 0 7.54605 Q5HY92 FIGN_HUMAN Fidgetin FIGN Homo sapiens (Human) cell division [GO:0051301] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nuclear matrix [GO:0016363] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568] IIHASFLVAR;SILLFGPRGTGKTLLGR 2 3.6 0.41182 0.204 8.59641 0 0 0 0 7.81301 0 0 0 0 0 0 Q5HY98 ZN766_HUMAN Zinc finger protein 766 ZNF766 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECGKLFNR;ITYLVRHQKIHTR 2 4.5 0.58878 0.17878 0 0 0 0 0 0 9.76891 0 0 0 0 0 Q5HYC2 BRD10_HUMAN Uncharacterized bromodomain-containing protein 10 BRD10 KIAA2026 Homo sapiens (Human) nucleus [GO:0005634] DVLNENLQR;ELWTTDEGEGDLGKDSPK;FIENQEK;IQRVPRIK;IQVQPMVDPK;KSGKWYHR;LEMMLEQK;LLNELLPWEPK;SGGRGGR;TLLKTLK 10 4.4 0.97658 -5.3747 0 10.2433 5.35804 0 0 0 10.387 11.7247 11.7372 9.81794 0 10.5168 Q5HYJ1 TECRL_HUMAN "Trans-2,3-enoyl-CoA reductase-like (EC 1.3.1.-) (Steroid 5-alpha-reductase 2-like 2 protein)" TECRL SRD5A2L2 Homo sapiens (Human) very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]" HSKTTHFEIEIFDAQTRK 1 5 0.84933 -0.077564 0 0 0 0 0 8.99509 0 0 0 0 0 0 Q5HYJ3 FA76B_HUMAN Protein FAM76B FAM76B Homo sapiens (Human) mRNA stabilization [GO:0048255]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; negative regulation of protein export from nucleus [GO:0046826] nuclear speck [GO:0016607] DQHHPKHHHHHHHHHHRHSSSHHK;KYGPPQTCEQCKQQCAFDR;RLLQQRDQTILEK 3 16.5 0.26109 0.26876 8.73833 0 0 0 0 6.76354 0 0 7.94889 0 0 0 Q5HYK3 COQ5_HUMAN "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)" COQ5 Homo sapiens (Human) methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142] "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]" AQQNLSWEEIAK 1 3.7 0.91667 -0.34366 0 0 0 0 0 0 0 0 0 10.531 0 0 Q5HYK7 SH319_HUMAN SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) SH3D19 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of cell morphogenesis [GO:0022604] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] proline-rich region binding [GO:0070064] IPAKPGK;LAGASQAK;RGDRIQILER 3 3.2 0.96004 -1.0532 12.8996 8.22173 0 0 0 0 0 8.89415 0 0 0 0 Q5HYK9 ZN667_HUMAN Zinc finger protein 667 ZNF667 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AFSHRISLTR;LVSAQQK 2 2.8 0.98063 -1.6365 0 0 0 0 0 0 0 0 0 0 9.17914 0 Q5HYM0 ZC12B_HUMAN Probable ribonuclease ZC3H12B (EC 3.1.-.-) (MCP-induced protein 2) (Zinc finger CCCH domain-containing protein 12B) ZC3H12B CXorf32 MCPIP2 Homo sapiens (Human) cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] CKYYHPER;LSTVKTMSEGTLAK;TMSEGTLAKCGTGMSSAK 3 3.7 0.83929 -0.039297 0 0 0 0 0 0 0 0 5.36842 9.89318 0 0 Q5HYN5 CT451_HUMAN Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) CT45A1 CT45-1 Homo sapiens (Human) KRFFESIIK 1 4.8 0.82571 -0.021224 0 0 0 0 0 0 0 0 0 9.62985 0 0 Q5HYW2 NHSL2_HUMAN NHS-like protein 2 NHSL2 Homo sapiens (Human) cell differentiation [GO:0030154] ISLQSQEEAEK;LETGPGGASRFR;LIQQRHMPERPSKIGLLTSGTSR;LRSVSKSEPEDDIESPEYAEEPR;RTVVPQR;RTVVPQRLCPR 6 6.5 0.97629 -4.6866 8.75836 9.10596 0 0 9.18646 5.46881 0 7.57024 0 6.81737 0 0 Q5HYW2 NHSL2_HUMAN NHS-like protein 2 NHSL2 Homo sapiens (Human) cell differentiation [GO:0030154] ISLQSQEEAEK;LETGPGGASRFR;LIQQRHMPERPSKIGLLTSGTSR;LRSVSKSEPEDDIESPEYAEEPR;VTSTPQADSEREASPLG 5 12.1 0.91584 -0.43388 0 0 0 0 0 0 0 0 0 12.087 0 0 Q5HYW3 RTL5_HUMAN Retrotransposon Gag-like protein 5 (Retrotransposon gag domain-containing protein 4) RTL5 KIAA2001 RGAG4 Homo sapiens (Human) EEEEMKKEEEMK;LHSKDQRK 2 3.5 0.97426 -2.4555 0 0 0 10.9247 10.0974 10.2783 0 0 0 0 0 0 Q5I0G3 MDH1B_HUMAN Putative malate dehydrogenase 1B (EC 1.1.1.-) MDH1B Homo sapiens (Human) malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] L-malate dehydrogenase (NAD+) activity [GO:0030060] GIVFSMPVK 1 1.7 0.90984 -0.31566 0 0 0 0 9.65612 0 0 0 0 0 0 0 Q5IJ48 CRUM2_HUMAN Protein crumbs homolog 2 (Crumbs-like protein 2) CRB2 Homo sapiens (Human) circulatory system development [GO:0072359]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; ingression involved in gastrulation with mouth forming second [GO:0055111]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm formation [GO:0001707]; negative regulation of endopeptidase activity [GO:0010951]; notochord formation [GO:0014028]; photoreceptor cell maintenance [GO:0045494]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of gastrulation [GO:0010470]; retina homeostasis [GO:0001895]; retinal cone cell development [GO:0046549]; somitogenesis [GO:0001756]; visual perception [GO:0007601] apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003] aspartic-type endopeptidase inhibitor activity [GO:0019828]; calcium ion binding [GO:0005509]; protein-containing complex binding [GO:0044877] CHTHPDGR 1 0.6 0.93707 -0.5424 0 0 0 0 0 0 0 0 0 10.8367 0 0 Q5J5C9 DB121_HUMAN "Beta-defensin 121 (Beta-defensin 21) (DEFB-21) (Defensin, beta 121)" DEFB121 DEFB21 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular region [GO:0005576] CWGKSGRCR 1 11.8 0.97538 -1.4729 0 0 0 0 10.2655 0 0 0 0 0 0 11.3436 Q5J8M3 EMC4_HUMAN ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) EMC4 TMEM85 HSPC184 PIG17 Homo sapiens (Human) apoptotic process [GO:0006915]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] KQRLVPMYLGLIYILL;LVPMYLGLIYILL 2 10.7 0.84828 -0.06674 0 0 7.3482 0 0 3.10841 0 0 0 0 0 0 Q5J8X5 M4A13_HUMAN Membrane-spanning 4-domains subfamily A member 13 (Testis-expressed transmembrane protein 4) MS4A13 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] VTKYPTR 1 6.2 0.98014 -1.6006 0 0 0 0 10.2215 0 0 0 0 0 0 0 Q5JNZ3 ZN311_HUMAN Zinc finger protein 311 (Zinc finger protein zfp-31) ZNF311 ZFP31 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVDPCVQDPQDR;HYGCPQCGKDFSIKAELTK 2 4.7 0.96344 -1.0842 0 0 3.06335 0 0 0 0 9.41745 0 0 0 0 Q5JPB2 ZN831_HUMAN Zinc finger protein 831 ZNF831 C20orf174 Homo sapiens (Human) metal ion binding [GO:0046872] AGGRKCGQR;ASPHGGK;NAGKYLCPHCGRDCLKPSVLEK;SPTAGKPCALQR 4 3 0.91618 -0.36487 0 0 8.7162 10.8399 0 0 10.0877 0 0 0 0 0 Q5JPE7 NOMO2_HUMAN BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) NOMO2 Homo sapiens (Human) multi-pass transmembrane protein insertion into ER membrane [GO:0160063] endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022] ISIMHEDWCWKNK;VTPRSCHR 2 1.7 0.95518 -0.78764 0 0 7.26021 0 0 0 0 0 8.86623 0 0 0 Q5JPH6 SYEM_HUMAN "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS)" EARS2 KIAA1970 Homo sapiens (Human) glutamyl-tRNA aminoacylation [GO:0006424]; tRNA aminoacylation for mitochondrial protein translation [GO:0070127] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; glutamate-tRNA(Gln) ligase activity [GO:0050561]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] LSEGLEGTK 1 1.7 0.92102 -0.44161 0 0 0 0 0 9.99788 0 0 0 0 0 0 Q5JPI3 CC038_HUMAN Uncharacterized protein C3orf38 C3orf38 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065] nucleus [GO:0005634] QPQLKLK 1 2.1 0.69317 0.16233 0 0 0 0 0 0 0 0 0 0 10.0896 0 Q5JQC9 AKAP4_HUMAN A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4) AKAP4 AKAP82 Homo sapiens (Human) cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] cAMP-dependent protein kinase complex [GO:0005952]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm end piece [GO:0097229]; sperm fibrous sheath [GO:0035686]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; Z disc [GO:0030018] protein kinase A binding [GO:0051018] CEDPCEGENK;GVCKVDLYNPEGQQDQDRK;MAYSDTTMMSDDIDWLRSHR 3 5.7 0.936 -0.53707 5.49637 0 11.4973 0 0 0 0 0 0 0 0 0 Q5JQF7 CF100_HUMAN Putative uncharacterized protein encoded by LINC01556 LINC01556 C6orf100 Homo sapiens (Human) YIYESPNHR 1 14.5 0.93781 -0.56876 0 0 0 0 0 0 0 0 0 7.87227 0 0 Q5JQF8 PAP1M_HUMAN Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32) PABPC1L2A PABPC1L2 RBM32A; PABPC1L2B PABPC1L2 RBM32B Homo sapiens (Human) cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] ALETLNFDVIKGRPVR;FSPAGPILSIR;GYGFVHFQK;SLGYAYVNYQQPVDAKR;VACDEKGPK;VACDEKGPKGYGFVHFQK 6 31 0.9807 -1.5948 0 4.85055 11.7308 0 0 0 0 7.41261 12.1187 0 0 0 Q5JQS6 GSAML_HUMAN Germinal center-associated signaling and motility-like protein GCSAML C1orf150 Homo sapiens (Human) regulation of B cell receptor signaling pathway [GO:0050855]; regulation of lymphocyte migration [GO:2000401] RQEMTTFERK 1 7.4 0.97399 -1.4024 0 10.2723 0 0 0 0 0 0 0 0 0 0 Q5JR12 PPM1J_HUMAN Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) PPM1J PPP2CZ Homo sapiens (Human) signal transduction [GO:0007165] mitochondrion [GO:0005739] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] LPWSTGYAEVINAGKSR 1 3.4 0.94584 -0.65218 0 0 0 0 9.76679 0 0 0 0 0 0 0 Q5JR59 MTUS2_HUMAN Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) MTUS2 CAZIP KIAA0774 TIP150 Homo sapiens (Human) cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] EENLSALEGR;EVTTSVAENR;NGFPPKPDPQAR;SIQGPSLSSWR;TLDNEELR 5 3.7 0.97537 -2.3513 0 0 0 0 0 7.57705 0 0 0 0 0 0 Q5JRA6 TGO1_HUMAN Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) MIA3 KIAA0268 TANGO UNQ6077/PRO20088 Homo sapiens (Human) cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of lymphocyte migration [GO:2000402]; positive regulation of leukocyte migration [GO:0002687]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; protein transport [GO:0015031]; vesicle cargo loading [GO:0035459]; wound healing [GO:0042060] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] cargo receptor activity [GO:0038024] EDSLDEEFFHHK;LSAADEKAVSAAEEVK;TIMKENTELVQK;TLQDMEKNPELSKER;TNNDKEVNAEHHIKGK;VEILNELYQQKEMALQKK;VPGQLDPSTGRR 7 5.3 0.90709 -0.30403 12.5842 0 0 8.79516 0 0 0 12.0483 0 7.92285 0 0 Q5JRC9 FA47A_HUMAN Protein FAM47A FAM47A Homo sapiens (Human) EPTEPHK;VLDSGRTLKDVWDR;VSSLHPEPPK 3 3.9 0.9551 -0.79287 0 9.01959 0 6.83175 0 0 0 0 9.13281 0 0 0 Q5JRV8 T255A_HUMAN Transmembrane protein 255A (Protein FAM70A) TMEM255A FAM70A Homo sapiens (Human) response to bacterium [GO:0009617] membrane [GO:0016020] EVNCPHLSR 1 2.6 0.91025 -0.31644 0 0 0 0 0 0 9.82139 0 0 0 0 0 Q5JRX3 PREP_HUMAN "Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)" PITRM1 KIAA1104 MP1 PREP Homo sapiens (Human) protein processing [GO:0016485]; protein targeting to mitochondrion [GO:0006626]; proteolysis [GO:0006508] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GVVFNEMK;LGNQLAK;LTLSMRPDDK 3 2.4 0.96427 -1.196 0 11.4115 0 0 0 0 0 12.0607 9.41449 0 0 0 Q5JS13 RGPS1_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) RALGPS1 KIAA0351 RALGEF2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LDYLMSK;SPWPRNLR 2 3.9 0.97964 -1.8509 12.8205 0 12.3701 0 0 0 11.8775 0 9.24665 11.4198 11.423 0 Q5JS13 RGPS1_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) RALGPS1 KIAA0351 RALGEF2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LDYLMSK;LVSSKEDLAAM 2 5.9 0.91722 -0.42522 0 0 0 0 0 0 0 0 0 6.01654 0 0 Q5JS37 NHLC3_HUMAN NHL repeat-containing protein 3 NHLRC3 Homo sapiens (Human) negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576] translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630] ILYRLDVGWPK;LDVGWPK 2 3.2 0.96318 -1.102 0 0 11.7288 0 0 0 0 0 0 0 0 0 Q5JSH3 WDR44_HUMAN WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) WDR44 RPH11 Homo sapiens (Human) cytosolic ciliogenesis [GO:0061824]; negative regulation of cilium assembly [GO:1902018]; regulation of vesicle-mediated transport [GO:0060627] cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] molecular sequestering activity [GO:0140313]; small GTPase binding [GO:0031267] EYVSNDAAQSDDEEKLQSQPTDTDGGR;NLDTGEEIPLSLAEEK;VALWNEVDGQTK;VLQLEDDSLDSKGK;YFLSGSLDGKLRLWNIPDK 5 9.6 0.98002 -2.0418 0 0 10.411 0 0 0 0 9.2351 0 0 9.84205 0 Q5JSJ4 INT6L_HUMAN Integrator complex subunit 6-like (Protein DDX26B) INTS6L DDX26B Homo sapiens (Human) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] DLKPQTYR;EIDPDQPK;ILASVGKKPPQEIGIK;VLIQYLEKVLEK 4 5.1 0.98053 -1.663 0 0 0 10.3972 0 0 0 0 0 9.30218 0 8.52654 Q5JSL3 DOC11_HUMAN Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) DOCK11 ZIZ2 Homo sapiens (Human) B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] IPNHVFEIDEDCEK;KIIQINTDSLVQEK;LQRVQDSNLEYSLSDEYCK;LYGEKFGTENVK;MRRHAFELK;TAKQVCSR;TAKQVCSRLGQYR;TWLDSMAK;YTAISVIKNLLIK 9 4.9 0.97804 -6.2291 0 0 5.50678 0 10.8906 8.49877 0 3.8339 13.1373 0 12.5634 0 Q5JSP0 FGD3_HUMAN "FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)" FGD3 ZFYVE5 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] LDSGHVWKLQWAK;LSVPDPEER 2 3 0.96241 -1.103 0 6.36335 5.34738 0 0 2.92926 0 0 0 0 0 0 Q5JST6 EFHC2_HUMAN EF-hand domain-containing family member C2 EFHC2 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; flagellated sperm motility [GO:0030317]; regulation of neuron projection development [GO:0010975] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] IYDCDAFTRNFLRK;NFKKFMEK;SFFSALNWRK 3 4.3 0.95568 -0.9881 0 11.3119 0 0 0 0 0 0 0 0 6.82909 0 Q5JSZ5 PRC2B_HUMAN Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) PRRC2B BAT2L BAT2L1 KIAA0515 Homo sapiens (Human) cell differentiation [GO:0030154] RNA binding [GO:0003723] DGRPKWNSWDPR;EHRPGPIGNERSLK;EVPWSPSAEK;FEEEEKPDK;LAACAAK;QFQMNDQDGK;QRRLLEEER;SGPIKKPVLKALK;WMMMPSYMDPR 9 4.3 0.98037 -2.006 0 9.07674 9.23026 0 8.37908 0 0 10.3286 0 11.1338 5.51986 11.8197 Q5JT25 RAB41_HUMAN Ras-related protein Rab-41 RAB41 Homo sapiens (Human) "intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] TEYQSLCKSK 1 4.5 0.92106 -0.44615 0 0 0 0 0 0 0 0 7.03342 0 0 0 Q5JT82 KLF17_HUMAN Krueppel-like factor 17 (Zinc finger protein 393) KLF17 ZNF393 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" CDQCSREFMR;GSSEARPYCCNYENCGK 2 6.9 0.81878 -0.017642 0 0 0 5.6781 0 0 0 0 0 0 4.62831 0 Q5JTD0 TJAP1_HUMAN Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) TJAP1 PILT TJP4 Homo sapiens (Human) Golgi organization [GO:0007030] bicellular tight junction [GO:0005923]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] LNPYPTPSPPHPLYPGRR;RLQNSYTASQRTNQELEDK;SHFRNHK 3 7.9 0.98116 -1.7514 0 0 0 0 7.02092 9.21342 0 0 0 8.71514 0 0 Q5JTD7 LRC73_HUMAN Leucine-rich repeat-containing protein 73 LRRC73 C6orf154 Homo sapiens (Human) GREPAAHQR;QLAEALRTNR 2 6 0.9733 -2.6431 0 0 0 0 0 0 0 0 0 0 8.85835 0 Q5JTH9 RRP12_HUMAN RRP12-like protein RRP12 KIAA0690 Homo sapiens (Human) cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] RNA binding [GO:0003723] KGRPDPYAYIPLNR;VLATQPGPGR;VPSPVLIKK 3 2.5 0.86579 -0.092444 0 0 2.62618 10.0101 0 0 0 0 0 0 0 0 Q5JTN6 WDR38_HUMAN WD repeat-containing protein 38 WDR38 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] NSGVPATLAVRRVK 1 4.5 0.76531 0.060903 0 0 0 0 0 0 0 0 7.50351 0 0 0 Q5JTV8 TOIP1_HUMAN Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) TOR1AIP1 LAP1 Homo sapiens (Human) nuclear membrane organization [GO:0071763]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504] nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; lamin binding [GO:0005521] AGDGRRAEAVR;FESFPAGSTLIFYK;LNGLWSR;TPQEWAPQTAR 4 7.4 0.9726 -2.7792 10.2199 0 0 0 0 0 0 9.77437 0 0 0 0 Q5JTW2 CEP78_HUMAN Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; negative regulation of protein ubiquitination [GO:0031397]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829] GKATIRIGLATK;KNPLIDHSMMK 2 3.3 0.77128 0.053058 0 0 0 5.29053 0 0 0 0 0 0 0 0 Q5JTW2 CEP78_HUMAN Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; negative regulation of protein ubiquitination [GO:0031397]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829] ATIRIVGLATKKPVSSGR;KNPLIDHSMMK 2 4 0.95368 -0.92875 0 0 0 0 0 0 0 4.7148 0 0 0 0 Q5JTZ5 CI152_HUMAN Uncharacterized protein C9orf152 C9orf152 Homo sapiens (Human) LEEAAQGCLQAPK;MEGLPCPCPALPHFWQLR 2 13 0.78339 0.024518 9.50841 10.4236 0 0 0 0 0 0 0 0 0 0 Q5JTZ9 SYAM_HUMAN "Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS2) (EC 6.-.-.-)" AARS2 AARSL KIAA1270 Homo sapiens (Human) alanyl-tRNA aminoacylation [GO:0006419]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]; negative regulation of cGAS/STING signaling pathway [GO:0160049] mitochondrion [GO:0005739] alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; peptide lactyltransferase (ATP-dependent) activity [GO:0141207]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] AATERLSLGSR;AGLDPDLETR;LWISYFDGDPK;VANSQKCVR 4 4.2 0.97401 -1.4128 7.35896 0 0 0 0 0 10.6475 0 0 10.1733 0 0 Q5JU00 DRC5_HUMAN Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1) TCTE1 DRC5 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] GARGAAK;NFQKNPILKQMLPEHQQK 2 5 0.12094 0.35968 0 11.8517 9.92172 9.49422 0 0 0 0 0 0 0 0 Q5JU85 IQEC2_HUMAN IQ motif and SEC7 domain-containing protein 2 IQSEC2 KIAA0522 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of ARF protein signal transduction [GO:0032012]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]" cytoplasm [GO:0005737]; Schaffer collateral - CA1 synapse [GO:0098685] guanyl-nucleotide exchange factor activity [GO:0005085] EAVYRDKER;ESQFHQAARDVGYPNREGAYQNR;EVFLFNDLLVVTKIFQK;EVFLFNDLLVVTKIFQKK;QMIGEFLGNR;QTYQRETR;RRIEELEGQLDQLTQENR 7 5.8 0.97672 -2.1744 10.8711 0 0 9.76542 0 9.02486 12.3207 7.88783 0 9.15851 0 0 Q5JUK3 KCNT1_HUMAN Potassium channel subfamily T member 1 (KCa4.1) (KNa1.1) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2) KCNT1 KIAA1422 SLACK Slo2.2 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289] plasma membrane [GO:0005886] intracellular sodium-activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271] AKDSYSLALSK;APFCCLRLDKGCK;APKQAGR;EVKGPWGSRAGTGGSSQGR;LQDYYVVILCPTEMDVQVRRVLQIPLWSQR 5 6.5 0.9806 -1.6466 0 10.2891 11.3426 0 0 0 7.66021 8.21106 8.328 0 0 11.3322 Q5JUR7 TEX30_HUMAN Testis-expressed protein 30 TEX30 C13orf27 Homo sapiens (Human) AYKSVLNYLK;AYKSVLNYLKTSGEYK 2 7 0.97391 -1.42 0 0 0 0 0 0 0 0 10.6284 0 0 0 Q5JUW0 KRBX4_HUMAN KRAB domain-containing protein 4 (KRAB box domain-containing protein 4) KRBOX4 ZNF673 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] YYSWEKAFK 1 5.3 0.98008 -1.5695 0 0 0 8.27877 0 0 0 0 0 0 0 0 Q5JV73 FRPD3_HUMAN FERM and PDZ domain-containing protein 3 FRMPD3 KIAA1817 Homo sapiens (Human) cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821] QATGEVAGK;QVTVHRDPIYGFGFVAGSERPVVVR;SLSQQLKAHQTHPSCGTK;TDVNENLIFFEETRPRTK 4 3.9 0.95515 -0.88236 0 0 0 0 0 0 0 0 10.2967 7.74322 8.05458 9.18982 Q5JVF3 PCID2_HUMAN PCI domain-containing protein 2 (CSN12-like protein) PCID2 HT004 Homo sapiens (Human) heterochromatin organization [GO:0070828]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lymphoid progenitor cell differentiation [GO:1905457]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein transport [GO:0015031]; regulation of mRNA stability [GO:0043488]; spleen development [GO:0048536]; transcription elongation by RNA polymerase II [GO:0006368] cytoplasm [GO:0005737]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723] AGIEDSKK;CQTVIVQYPLSFMAAVPHR;CTYAVGNHDFIEAYK 3 9.3 0.94068 -0.58681 0 0 0 0 0 9.48585 0 0 0 0 5.10685 0 Q5JVG2 ZN484_HUMAN Zinc finger protein 484 ZNF484 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFIQKSTLSMHQRIHR 1 1.9 0.44831 0.19164 0 0 0 0 10.7215 10.7809 11.8887 0 0 0 0 0 Q5JVG8 ZN506_HUMAN Zinc finger protein 506 ZNF506 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KIHIRQKPCIVK 1 2.7 0.87016 -0.096082 0 0 0 0 0 0 0 0 0 0 6.87344 0 Q5JVL4 EFHC1_HUMAN EF-hand domain-containing protein 1 (Myoclonin-1) EFHC1 Homo sapiens (Human) cerebral cortex cell migration [GO:0021795]; cilium-dependent cell motility [GO:0060285]; flagellated sperm motility [GO:0030317]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922] alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509] DNIREAFQIYDK;DNIREAFQIYDKEASGYVDR;EAFQIYDK;VLVENAK 4 4.2 0.98122 -1.7086 0 0 0 0 7.8042 0 8.76045 0 0 0 0 0 Q5JVL4 EFHC1_HUMAN EF-hand domain-containing protein 1 (Myoclonin-1) EFHC1 Homo sapiens (Human) cerebral cortex cell migration [GO:0021795]; cilium-dependent cell motility [GO:0060285]; flagellated sperm motility [GO:0030317]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922] alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509] GLGSCIGNYFETLQL 1 5.4 0.87403 -0.11945 0 9.89912 0 0 0 0 0 0 0 0 0 0 Q5JVX7 CA141_HUMAN Uncharacterized protein C1orf141 C1orf141 Homo sapiens (Human) SNLRPFFIQTNVKNKESESTAQIEK;TNKQTLENR 2 8.5 0.86994 -0.094681 0 0 0 0 0 5.19495 0 11.312 0 0 10.4882 0 Q5JWF8 ACL10_HUMAN Actin-like protein 10 ACTL10 C20orf134 Homo sapiens (Human) LDKELEAQCRR;LLYDVFN 2 7.3 0.9722 -1.3567 0 8.95919 0 0 0 0 8.30533 0 0 0 0 0 Q5JWR5 DOP1A_HUMAN Protein DOP1A DOP1A DOPEY1 KIAA1117 Homo sapiens (Human) Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; trans-Golgi network [GO:0005802] DLQDVTHK;DMKLENHKPCSSK;DSIQLSLPAPGQFLILGVLNEFIMKNPSLENKK;EQGETSKWDR;GFPSFISDMLSKCK;HDIARVLEPLLLLLLHPKTQR;IEEMVEKDFLEGMIKT;IRMEAHAK;VIESSAK;VLQRLIVLEHR;VQKVILHCLLSSIFSAQK 11 6.5 0.97666 -5.5413 0 0 10.5348 0 0 0 7.51995 9.52941 8.6838 9.99887 6.35172 0 Q5JXC2 MIIP_HUMAN Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) MIIP IIP45 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] HCLLGWDIFPPKSEKSSAPR;VTFSEESAVPKR 2 8.2 0.78375 0.030348 0 0 0 0 0 0 12.4715 0 0 6.13677 0 0 Q5JY77 GASP1_HUMAN G-protein coupled receptor-associated sorting protein 1 (GASP-1) GPRASP1 GASP KIAA0443 Homo sapiens (Human) endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172] cytosol [GO:0005829]; nucleus [GO:0005634] ELQGKTDNQNDPEGDQEN;STCSVEQEPDPSR;TPWFWARDKTNTWSGPR;VCEETLAYSVDSPEQLSGIR 4 4.9 0.93304 -0.50183 6.63417 0 0 0 9.0621 0 8.16033 0 0 0 0 0 Q5JZY3 EPHAA_HUMAN Ephrin type-A receptor 10 (EC 2.7.10.1) EPHA10 Homo sapiens (Human) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LGGSRPRK 1 0.8 0.73119 0.11366 0 0 0 0 0 0 0 0 0 0 6.47314 0 Q5K4E3 POLS2_HUMAN Polyserase-2 (EC 3.4.21.-) (Polyserine protease 2) (Serine protease 36) PRSS36 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] LVISIRLPQHLGLRPPLALLELSSR 1 2.9 0.83875 -0.039211 0 0 0 0 0 4.55906 0 0 0 0 0 0 Q5K4L6 S27A3_HUMAN Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-) SLC27A3 ACSVL3 FATP3 PSEC0067 UNQ367/PRO703 Homo sapiens (Human) fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] AALLLLPLLLLLPLLLLKLHLWPQLR;MAALLLLPLLLLLPLLLLKLHLWPQLR;SKFSAGQFWEDCQQHR 3 6.3 0.95273 -0.76123 0 0 0 7.63212 0 8.13443 0 0 0 0 0 0 Q5K651 SAMD9_HUMAN Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) endosomal vesicle fusion [GO:0034058]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] GGKVSWWNFYFSSESYSSPFVKR;LDLDSEK;LISFLTHEDIMPR;LVKPVEK;LYPKSKR;RLLPSIGLSTVLLKK;VELIEDK;VQELLLR 8 5.4 0.97314 -2.8661 0 0 7.6011 3.81106 0 0 9.38778 10.3481 4.09651 0 0 0 Q5KSL6 DGKK_HUMAN Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa) DGKK Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; response to oxidative stress [GO:0006979] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] CLWCNSTVHDDCRR;EDEAEGDDPLTPSR;SPLDILNR;SSDTDSR;VEEERKPK 5 4 0.95527 -0.87298 0 0 0 0 11.6745 0 8.38422 9.97197 9.24975 0 0 0 Q5KU26 COL12_HUMAN Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) "carbohydrate mediated signaling [GO:0009756]; cellular response to exogenous dsRNA [GO:0071360]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; plasma membrane raft organization [GO:0044857]; toll-like receptor 3 signaling pathway [GO:0034138]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle membrane [GO:0030666]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] galactose binding [GO:0005534]; low-density lipoprotein particle binding [GO:0030169]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044] AISTNSELSTFR;CKNNWALK;LVDSKHGQLIK;NFTILQGPPGPRGPRGDR 4 6.6 0.97334 -2.6326 0 10.2723 0 0 0 0 11.2143 11.0745 9.34877 0 0 9.75029 Q5M775 CYTSB_HUMAN Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) SPECC1 CYTSB NSP5 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; associative learning [GO:0008306]; blastocyst development [GO:0001824] apical part of cell [GO:0045177]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654] KTATAGAISELTESRLR;LLSASTR 2 2.2 0.94215 -0.61603 0 0 0 0 0 0 0 11.7973 0 0 9.16669 0 Q5M7Z0 RNFT1_HUMAN E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) RNFT1 PTD016 Homo sapiens (Human) positive regulation of ERAD pathway [GO:1904294]; protein autoubiquitination [GO:0051865] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] ECAENASSRNIR;YLISYGEFGNVTR 2 5.7 0.91599 -0.4328 0 0 0 0 0 0 0 0 11.0503 0 0 6.14845 Q5M9N0 CD158_HUMAN Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) EAKRMYEDK;EKELSLEKEQNK;EPVTLHAGDR;IEQLISEHEVEITGLTEKASSAR;LSQELSTVATEKNK;LVNAGSERLR;NEGDHLR;QKFYLRQSVIDLQTK;VAMGMQKQITAK;VAMGMQKQITAKR;VLEEYSHQVK 11 11.1 0.9751 -3.3711 11.9894 0 10.2427 0 0 0 12.1227 0 11.5103 6.10666 11.981 0 Q5M9N0 CD158_HUMAN Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) EAKRMYEDK;EPVTLHAGDR;IEQLISEHEVEITGLTEKASSAR;QKFYLRQSVIDLQTK;TERDQSSLRSDMCHR;VLEEYSHQVK 6 15.4 0.86016 -0.081818 0 0 0 0 0 0 0 0 0 0 4.83845 3.52105 Q5M9N0 CD158_HUMAN Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) AVGAEFCIKKVMI;EAKRMYEDK;IEQLISEHEVEITGLTEKASSAR;QKFYLRQSVIDLQTK;SCHYWLCRFGFTLNFRFLTTK;VLEEYSHQVK 6 22.4 0.32454 0.24541 0 0 0 0 0 0 0 0 9.81275 6.00957 0 0 Q5M9Q1 NKAPL_HUMAN NKAP-like protein NKAPL C6orf194 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] nucleus [GO:0005634] chromatin binding [GO:0003682] YSDSDSNSESDTNSDSDDDKKR 1 5.5 0.56278 0.18276 0 0 0 0 0 0 0 4.17879 0 0 0 0 Q5MCW4 ZN569_HUMAN Zinc finger protein 569 ZNF569 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSQRTSLIVHMR;KAFSHKEK;SHTGEKPYKCDKCGK 3 5.2 0.97659 -2.2822 0 0 0 11.4373 10.2035 0 0 0 0 10.6429 0 0 Q5MIZ7 P4R3B_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) PPP4R3B KIAA1387 PP4R3B SMEK2 Homo sapiens (Human) DNA damage response [GO:0006974]; gluconeogenesis [GO:0006094]; positive regulation of gluconeogenesis [GO:0045722]; regulation of double-strand break repair [GO:2000779] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] EVIPITDSELR;TSPGGFK;VYTLNEDRQWDDR 3 3.7 0.89736 -0.24745 0 0 0 8.51373 0 0 0 0 0 0 0 9.70079 Q5MJ08 SPXN4_HUMAN Sperm protein associated with the nucleus on the X chromosome N4 (Nuclear-associated protein SPAN-Xn4) (SPANX-N4) (SPANX family member N4) SPANXN4 Homo sapiens (Human) SPCESNK 1 7.1 0.91092 -0.32572 0 0 0 0 0 0 0 0 0 5.64801 0 0 Q5MJ09 SPXN3_HUMAN Sperm protein associated with the nucleus on the X chromosome N3 (Nuclear-associated protein SPAN-Xn3) (SPANX-N3) (SPANX family member N3) SPANXN3 Homo sapiens (Human) MEQPTSSTNGEKTK;VLAPEQSLK 2 16.3 0.94121 -0.59839 11.3795 11.5681 11.2626 0 0 0 0 0 0 0 10.8537 0 Q5MJ68 SPDYC_HUMAN Speedy protein C (Rapid inducer of G2/M progression in oocytes C) (RINGO C) (hSpy/Ringo C) SPDYC Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] protein kinase binding [GO:0019901] VGKFLHQRDK;YLLAMVLVYFQR 2 8 0.37829 0.21934 0 7.63358 14.3805 0 0 0 6.34522 0 0 4.04998 0 0 Q5MJ70 SPDYA_HUMAN Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1) SPDYA SPDY1 SPY1 Homo sapiens (Human) DNA damage response [GO:0006974]; establishment of protein localization to telomere [GO:0070200]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiotic nuclear division [GO:0007140]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; spermatogenesis [GO:0007283]; telomere capping [GO:0016233] "chromosome, telomeric region [GO:0000781]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]" protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] KDKSMEWFTGSEE;YEIFPWALGKNWRK 2 8.6 0.97794 -2.1321 7.84336 0 0 0 0 0 11.1511 0 0 0 0 0 Q5MNZ9 WIPI1_HUMAN WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) WIPI1 WIPI49 Homo sapiens (Human) "autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]; vesicle targeting, trans-Golgi to endosome [GO:0048203]" autophagosome membrane [GO:0000421]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; trans-Golgi network [GO:0005802] "nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]" GTVIRVFSVPDGQK;LASASEK 2 4.7 0.97827 -1.9789 0 0 0 0 0 0 0 0 0 10.5462 0 0 Q5NDL2 EOGT_HUMAN EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT AER61 C3orf64 EOGT1 Homo sapiens (Human) protein O-GlcNAcylation via threonine [GO:0097370]; protein O-linked glycosylation [GO:0006493] endoplasmic reticulum lumen [GO:0005788] protein O-acetylglucosaminyltransferase activity [GO:0097363]; RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity [GO:0140842]; RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity [GO:0140843] LNITQEGPK;LNITQEGPKDGK;LPEEHIPFFLHNNR 3 4.9 0.97641 -2.2886 0 0 0 0 9.89488 0 0 0 0 0 9.66654 0 Q5NE16 CATL3_HUMAN Putative inactive cathepsin L-like protein CTSL3P (Cathepsin L3 pseudogene) (HCTSL-s) CTSL3P CTSL3 Homo sapiens (Human) GYVTPVK;QVVNGFQNQK 2 7.8 0.89814 -0.23301 0 3.57604 0 0 0 0 0 0 0 0 7.59044 0 Q5NUL3 FFAR4_HUMAN Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1) FFAR4 GPR120 GPR129 O3FAR1 PGR4 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; brown fat cell differentiation [GO:0050873]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; hormone secretion [GO:0046879]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production [GO:0001818]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of somatostatin secretion [GO:0090275]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of D-glucose transmembrane transport [GO:0010827]; white fat cell differentiation [GO:0050872] ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] arrestin family protein binding [GO:1990763]; fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] MVCIVHLQRGVR;SLEQANRTR 2 5.8 0.98005 -2.0118 0 0 0 0 10.4616 0 0 0 0 0 0 9.11533 Q5PRF9 SMAG2_HUMAN Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) SAMD4B SMAUG2 Homo sapiens (Human) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371] CLTHEAFTETQKKR;KAALEMQNYRQQK;QFPMPPRALPPGR 3 5.8 0.58849 0.1788 0 9.19131 0 8.71833 0 8.77926 0 0 0 9.89769 0 0 Q5PT55 NTCP5_HUMAN Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5) SLC10A5 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721] membrane [GO:0016020] bile acid:sodium symporter activity [GO:0008508] IRKLFIVLLLLLVTIEEAR;IVSTLLFILVPVSIGIVIK;KLFIVLLLLLVTIEEAR;MIRKLFIVLLLLLVTIEEAR 4 8.9 0.9547 -0.90235 0 0 7.57387 0 4.45108 0 0 4.58002 0 0 0 0 Q5QFB9 PAPAS_HUMAN Protein PAPPAS (DIPLA1 antisense RNA 1) (DIPLA1 antisense gene protein 1) (DIPLA1-antisense expressed) (PAPPAS antisense RNA 1) (PAPPAS antisense gene protein 1) (PAPPAS-antisense expressed) PAPPA-AS1 DIPAS PAPPAS Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] ICGHLCQK;LFLVSFFFFF 2 17.6 0.9654 -1.1611 0 0 0 0 0 0 0 11.0323 11.1046 0 0 0 Q5QGS0 NEXMI_HUMAN Neurite extension and migration factor (XLMR protein related to neurite extension) (XPN) NEXMIF KIAA2022 Homo sapiens (Human) negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399] cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DESGTASFEK;EPPVIIKYIIINRFK;GFWQKKK;SLKGNNK 4 2.6 0.97401 -3.0021 7.46499 0 0 7.874 0 0 0 0 0 10.956 0 0 Q5QGZ9 CL12A_HUMAN C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371) CLEC12A CLL1 DCAL2 KLRL1 MICL Homo sapiens (Human) negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of immune response [GO:0050777]; negative regulation of inflammatory response [GO:0050728]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of neutrophil activation [GO:1902564]; positive regulation of type I interferon production [GO:0032481]; signal transduction [GO:0007165] plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; pattern recognition receptor activity [GO:0038187]; signaling receptor regulator activity [GO:0030545]; transmembrane signaling receptor activity [GO:0004888] LYVQYYHCTYKKR;NLSTTLQTIATKLCR 2 10.6 0.98032 -1.55 0 0 8.46213 0 0 0 0 0 0 0 9.3226 0 Q5QJ38 TCHL1_HUMAN Trichohyalin-like protein 1 (Basalin) (Protein S100-A17) (S100 calcium-binding protein A17) TCHHL1 S100A17 THHL1 Homo sapiens (Human) transition metal ion binding [GO:0046914] GPEAHGTAGQK;NVLCVIETFHK;QSVGENTRVTK 3 3.7 0.97828 -2.0809 0 0 0 0 9.21291 0 0 10.7108 0 0 0 0 Q5QJ74 TBCEL_HUMAN Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) TBCEL LRRC35 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] alpha-tubulin binding [GO:0043014] DQPSGRSFMQVLCEK 1 3.5 0.91866 -0.43577 6.00717 0 0 0 0 0 0 0 0 0 0 0 Q5QJE6 TDIF2_HUMAN Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) DNTTIP2 ERBP TDIF2 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] NELLQKAVITPDFEK;SPIKASDLTK;TIVEELLADSEFRR;TIVEELLADSEFRRYNR 4 5.6 0.98045 -1.7136 0 0 0 4.72694 0 0 0 0 0 8.10245 10.4227 9.24046 Q5QP82 DCA10_HUMAN DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) DCAF10 WDR32 Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] SLEVGSYPILRAR 1 2.3 0.98207 -1.5879 0 17.0774 0 0 0 0 0 0 0 0 0 0 Q5R372 RBG1L_HUMAN Rab GTPase-activating protein 1-like RABGAP1L HHL KIAA0471 Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] KVVITVQQLSNK 1 1.5 0.68561 0.16333 0 0 2.58873 0 3.45667 0 0 0 0 0 0 0 Q5R372 RBG1L_HUMAN Rab GTPase-activating protein 1-like RABGAP1L HHL KIAA0471 Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] EEGVPCPAPAAK;GKMMACKHCSDIFSK;KSQDMHDER;LEQENDDLAHELVTSK 4 14.1 0.91059 -0.28732 6.34111 0 0 0 0 8.33159 0 0 0 4.69126 0 0 Q5R3F8 PPR29_HUMAN Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) ELFN2 KIAA1904 LRRC62 PPP1R29 Homo sapiens (Human) synaptic membrane adhesion [GO:0099560] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic density membrane [GO:0098839] protein phosphatase inhibitor activity [GO:0004864] RDSTYSQLSPR;SKRDSTYSQLSPR 2 1.6 0.9538 -0.89479 8.17253 0 0 9.4288 0 0 0 0 0 0 0 0 Q5RHP9 ERIC3_HUMAN Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) cilium assembly [GO:0060271] cytoplasm [GO:0005737]; non-motile cilium [GO:0097730] AERPKTSLR;EDVEGEEMVTEAEANR;EEVTRANALK;ENKTSVSAK;ENRSETWRR;ETFQFISKR;LSEARDTEHK;SLENITALRK 8 5.4 0.97691 -4.7595 0 0 9.82933 11.97 0 8.57671 0 10.9782 0 0 0 12.0844 Q5RL73 RBM48_HUMAN RNA-binding protein 48 RBM48 C7orf64 HSPC304 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] KAYVVKTTENK;TTQLQERK 2 5.2 0.97556 -2.3491 0 0 0 0 0 0 12.162 0 0 0 0 0 Q5S007 LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) "autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein binding [GO:0032091]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell projection organization [GO:0031344]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" "amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631] AFPMSER;ALTWHRKNK;ALYLAVYDLSK;DQLVVGQLIPDCYVELEK;ELLNKRGFPAIR;IILSERKNVPIEFPVIDR;KILLSKGIHLNVLELMQK;KSDLGMQSATVGIDVK;NFLLVGTADGKLAIFEDK;SSKLQSHMR;TEKLCGLIDCVHFLR 11 6 0.97677 -5.4503 8.97054 0 0 9.02081 7.66867 8.26318 10.182 0 12.1922 7.28216 6.51654 10.4988 Q5SGD2 PPM1L_HUMAN Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) PPM1L PP2CE Homo sapiens (Human) cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; MAPK cascade [GO:0000165]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] GCPDNITVMVVKFR 1 3.9 0.92188 -0.44332 0 6.11408 0 0 0 0 0 0 0 0 0 0 Q5SNT2 TM201_HUMAN Transmembrane protein 201 (Spindle-associated membrane protein 1) TMEM201 NET5 SAMP1 Homo sapiens (Human) centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435] cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] actin filament binding [GO:0051015]; lamin binding [GO:0005521] EDDSSQSSTCVVDTTTR;FSTTSLCCLVGFTAAVATRKATGPR;IKQLAAFAPREEGR 3 8.4 0.64033 0.17288 0 0 11.0564 0 0 0 0 0 0 0 0 0 Q5SNT2 TM201_HUMAN Transmembrane protein 201 (Spindle-associated membrane protein 1) TMEM201 NET5 SAMP1 Homo sapiens (Human) centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435] cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] actin filament binding [GO:0051015]; lamin binding [GO:0005521] FRPRRSEK;FSTTSLCCLVGFTAAVATRKATGPR;IKQLAAFAPREEGR 3 12 0.97356 -2.5512 9.11821 9.57886 0 0 0 0 0 0 0 0 0 0 Q5SNV9 CA167_HUMAN Uncharacterized protein C1orf167 C1orf167 Homo sapiens (Human) AILTQLRPAELRRFLR;GPESGQEAARAPRGWGLGAEHGAQLQL;GTAWAQR;GTAWAQRCR;IFLSWSRWATAQWAWR;LAARSPRR 6 5.2 0.97551 -3.3504 12.2786 0 9.02984 0 0 10.8694 0 9.43108 8.77175 9.56482 10.1839 0 Q5SQ64 LY66F_HUMAN Lymphocyte antigen 6 complex locus protein G6f LY6G6F C6orf21 G6F LY6G6D NG32 Homo sapiens (Human) plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] EEDAGRYWCAVLGQHHNYQNWR 1 7.4 0.82877 -0.025381 0 0 0 0 0 0 0 0 2.06977 0 7.69014 8.53555 Q5SQH8 CF136_HUMAN Uncharacterized protein C6orf136 C6orf136 Homo sapiens (Human) LVGLPVHLLFLRFYKR 1 5.1 0.48067 0.19047 0 0 0 0 7.56194 0 0 0 0 0 0 0 Q5SQI0 ATAT_HUMAN Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) ATAT1 C6orf134 MEC17 Nbla00487 Homo sapiens (Human) alpha-tubulin acetylation [GO:0071929]; cilium assembly [GO:0060271]; dentate gyrus development [GO:0021542]; microtubule cytoskeleton organization [GO:0000226]; neuron development [GO:0048666]; NLRP3 inflammasome complex assembly [GO:0044546]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of fat cell differentiation [GO:0045598]; regulation of microtubule cytoskeleton organization [GO:0070507]; response to mechanical stimulus [GO:0009612]; response to pain [GO:0048265]; spermatogenesis [GO:0007283] axon [GO:0030424]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule bundle [GO:0097427]; mitotic spindle [GO:0072686] "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; tubulin N-acetyltransferase activity [GO:0019799]" GAIIGFIKVGYKK 1 3.1 0.86993 -0.094467 0 0 0 0 0 0 0 0 0 0 6.93958 0 Q5SQN1 SNP47_HUMAN Synaptosomal-associated protein 47 (SNAP-47) (Epididymis luminal protein 170) (Synaptosomal-associated 47 kDa protein) SNAP47 C1orf142 HEL170 SVAP1 Homo sapiens (Human) exocytosis [GO:0006887]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082] endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] GHAKHWFSSLRPSRNVVFSIIEHFWR;VLHHQGQQLDSVMR 2 8.6 0.97857 -1.921 0 11.8492 0 0 0 0 11.3415 9.64023 0 0 0 0 Q5SQQ9 VAX1_HUMAN Ventral anterior homeobox 1 VAX1 Homo sapiens (Human) astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; central nervous system development [GO:0007417]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast proliferation [GO:0007405]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific double-stranded DNA binding [GO:1990837]" LEMEFQRCQYVVGRER 1 4.8 0.85024 -0.075876 0 0 0 0 0 0 0 0 0 0 5.88523 0 Q5SQS7 SH24B_HUMAN SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) cytoplasm [GO:0005737] EEQLRRWK;ELYWTLK;VSEKIWGYTLSYR;WFKEEQLPRR 4 8.8 0.88853 -0.18389 0 9.09777 0 0 0 0 0 0 0 0 0 0 Q5SQS7 SH24B_HUMAN SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) cytoplasm [GO:0005737] EEQLRRWK;ELYWTLK;VTSGTLR;WFKEEQLPRR 4 9 0.95589 -0.86994 0 10.5718 0 0 11.2664 0 0 0 11.9006 0 0 0 Q5SQS8 CJ120_HUMAN Uncharacterized protein C10orf120 C10orf120 Homo sapiens (Human) EDNYDTHNCDDANQDK;IWSKFYR 2 6.9 0.96468 -1.1186 0 7.72076 0 0 0 0 0 0 0 0 0 0 Q5SRE5 NU188_HUMAN Nucleoporin NUP188 (hNup188) NUP188 KIAA0169 Homo sapiens (Human) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] DSMETDDCSR;QELSSELSTLLSSLSRYFRR;QQFEELYKTEAPTWETHGNLMTERQVSR 3 3.3 0.96599 -1.1264 0 0 6.45595 0 0 0 0 3.96883 4.29499 0 0 10.2967 Q5SRH9 TT39A_HUMAN Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6) TTC39A C1orf34 KIAA0452 Homo sapiens (Human) centrosome [GO:0005813] ELDSLVQSSQYCK;YLGRVQEAEENFR 2 4.2 0.91734 -0.42771 0 0 0 0 0 5.81106 0 0 7.09233 0 0 0 Q5SRH9 TT39A_HUMAN Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6) TTC39A C1orf34 KIAA0452 Homo sapiens (Human) centrosome [GO:0005813] EEEAFVVPGILTGRYR;ELDSLVQSSQYCK 2 6.9 0.81485 -0.016584 4.17049 0 0 0 0 0 0 0 0 0 0 0 Q5SRI9 MANEA_HUMAN "Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)" MANEA Homo sapiens (Human) Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "alpha-mannosidase activity [GO:0004559]; glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]" YIIDKYGNHPAFYR 1 3 0.95273 -0.67684 0 0 0 0 9.97398 0 0 0 0 0 0 0 Q5SRN2 TSBP1_HUMAN Testis-expressed basic protein 1 (Uncharacterized protein C6orf10) TSBP1 C6orf10 Homo sapiens (Human) membrane [GO:0016020]; nucleus [GO:0005634] EPEREGKGTDLEK;IGMEVKVDSDAGIPK;TEADVPK 3 6.2 0.98129 -1.7051 0 0 0 0 0 0 0 0 0 7.23735 7.55321 0 Q5SSJ5 HP1B3_HUMAN Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) HP1BP3 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleus size [GO:0097298] chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleosome binding [GO:0031491] ATDTSQGELVHPK;DEDEDEDESSEEDSEDEEPPPK;GQLEQITGK;GSKPAPK;KEPDDSRDEDEDEDESSEEDSEDEEPPPK;LRVDIRPQLLKNALQR;TIPSWATLSASQLAR 7 16.1 0.05026 0.47987 14.0958 0 14.1265 14.2145 0 11.8583 0 7.36588 11.6472 14.04 0 12.4859 Q5SSJ5 HP1B3_HUMAN Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) HP1BP3 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleus size [GO:0097298] chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleosome binding [GO:0031491] DEDEDEDESSEEDSEDEEPPPK;GQLEQITGK;GSKPAPK;KEPDDSRDEDEDEDESSEEDSEDEEPPPK;LRVDIRPQLLKNALQR;MASSPRPK 6 17.2 0.93675 -0.54542 0 8.02398 0 0 0 0 0 0 0 0 0 0 Q5SSQ6 SAPC1_HUMAN Suppressor APC domain-containing protein 1 (Protein G7d) SAPCD1 C6orf26 G7D NG23 Homo sapiens (Human) EQNLWQQQELSRQQKGVTQPK;GPRGPTR 2 15.7 0.97489 -1.4306 0 0 0 0 0 0 0 11.9191 0 9.90132 0 0 Q5ST30 SYVM_HUMAN "Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (Valyl-tRNA synthetase-like)" VARS2 KIAA1885 VARS2L VARSL Homo sapiens (Human) valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] AAKAVESGALELSPSFHQK;LRSGNLDPAELAIVAAAQK;SPAESIK 3 4.2 0.96474 -1.1404 0 0 0 0 0 0 0 0 0 11.9291 0 0 Q5SV97 PERM1_HUMAN PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) PERM1 C1orf170 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; response to muscle activity [GO:0014850] cytoplasm [GO:0005737]; nucleus [GO:0005634] QVGQGRRSHSPSPSS 1 1.9 0.75917 0.071429 0 0 0 0 0 0 0 0 0 0 7.73728 0 Q5SVJ3 SMIP3_HUMAN Protein SPMIP3 (Sperm-associated microtubule inner protein 3) SPMIP3 C1orf100 Homo sapiens (Human) TKYHYQPQLDQQTLIR;YHYQPQLDQQTLIR 2 10.9 0.91758 -0.40748 0 0 0 0 0 0 0 11.4466 0 7.84718 0 0 Q5SVQ8 ZBT41_HUMAN Zinc finger and BTB domain-containing protein 41 ZBTB41 FRBZ1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IFQTETKQYMDQPK;IHSGEKAHQCEECGKCFGR;KLLSSLQYNKNLLK;LSNNHQCKFCSR;MLERSFSAR;NLLKYLNDDR;SLENHLAK;YECDECGK 8 9.9 0.97332 -2.9106 12.9455 8.99597 12.47 11.569 4.51633 0 0 0 12.6839 10.7632 10.5 13.4135 Q5SVZ6 ZMYM1_HUMAN Zinc finger MYM-type protein 1 ZMYM1 Homo sapiens (Human) nucleus [GO:0005634] protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270] FYRHYAK;IAAEFKK;LTGPALMAVEQELVNK;NIYRLSQNKTCK;SEMHLKSLEFWR;TEPDNAQEYCHR 6 5.8 0.97281 -2.5953 9.86037 0 0 0 0 0 11.003 7.24878 6.93369 8.80552 0 0 Q5SW79 CE170_HUMAN Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) CEP170 FAM68A KAB KIAA0470 Homo sapiens (Human) centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; spindle [GO:0005819] DNDDDQSDK;FTIQLQLSQK;GGDKKESSK;IDLLAQPR;ISQDLALIAR;QDTELQEK;SSESELSKSASAKSIDSK;VPEEALK;VPEEALKHEKFTIQLQLSQK;VTIRDHVTK 10 5.7 0.97851 -6.8109 11.8355 0 0 0 0 9.83621 9.5533 10.896 6.48325 10.6802 0 0 Q5SW96 ARH_HUMAN Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) LDLRAP1 ARH Homo sapiens (Human) amyloid precursor protein metabolic process [GO:0042982]; cellular response to cytokine stimulus [GO:0071345]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; low-density lipoprotein particle clearance [GO:0034383]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of protein binding [GO:0043393]; regulation of protein localization to plasma membrane [GO:1903076] axon [GO:0030424]; basal plasma membrane [GO:0009925]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] "amyloid-beta binding [GO:0001540]; AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]" ASGKKLQK;QSWGGGGRHR 2 5.8 0.97261 -2.8152 0 7.99424 0 0 0 0 0 0 0 0 0 0 Q5SWA1 PR15B_HUMAN Protein phosphatase 1 regulatory subunit 15B PPP1R15B Homo sapiens (Human) ER overload response [GO:0006983]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein phosphorylation [GO:0001933]; regulation of translation [GO:0006417]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542] endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164] protein phosphatase regulator activity [GO:0019888] LLSQLLAPLPGLLQK 1 2.1 0.89565 -0.22852 0 0 0 0 0 0 9.15702 0 0 0 0 0 Q5SWH9 TMM69_HUMAN Transmembrane protein 69 TMEM69 C1orf154 HSPC229 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] IVVTLLATFSFIITLVVK 1 7.3 0.68412 0.16402 0 0 6.75261 0 0 0 0 0 0 0 0 0 Q5SXH7 PKHS1_HUMAN Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185) PLEKHS1 C10orf81 Homo sapiens (Human) ACMESDWCR 1 1.9 0.84763 -0.071779 0 0 0 3.77684 0 0 0 0 0 0 0 0 Q5SXM1 ZN678_HUMAN Zinc finger protein 678 ZNF678 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGEKRYK;IYTGEEPDK;SILTEHKR;VFNRCSNLTK 4 6.9 0.97254 -2.8137 0 9.3054 0 0 0 0 0 0 0 0 11.9369 0 Q5SXM2 SNPC4_HUMAN snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) SNAPC4 SNAP190 Homo sapiens (Human) snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185] DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] DKTLPEDPETCLQLNMVYQEVIQEK;EWTEEEDR;SAFQCLQKFQQHNK 3 3.2 0.97653 -1.4874 0 0 0 0 0 0 0 5.67728 7.25456 0 0 0 Q5SY13 COAS1_HUMAN Putative uncharacterized protein encoded by COL5A1-AS1 (COL5A1 antisense RNA 1) (COL5A1 antisense gene protein 1) COL5A1-AS1 C9orf104 Homo sapiens (Human) EASISWAETSR;EATRNPIAEVLAR 2 42.9 0.98163 -1.5891 0 0 6.44561 0 0 8.71462 0 0 0 0 0 0 Q5SY16 NOL9_HUMAN Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) NOL9 Homo sapiens (Human) "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]" intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]; RNA binding [GO:0003723] ARPQLILSRRPR;ARPQLILSRRPRR;LAAFADALEFADEEK 3 4 0.93601 -0.53211 3.87735 0 0 0 0 0 0 2.66889 0 0 0 0 Q5SY80 CTSRE_HUMAN Cation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon) CATSPERE C1orf101 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] DKCPYMAFHNNVAHVFYFLDK;IVVPMTK;SYLRHQPSKNLR 3 4.2 0.98111 -1.7835 0 0 0 8.75756 0 8.67726 0 0 0 0 0 9.65288 Q5SY85 F201A_HUMAN Protein FAM201A FAM201A C9orf122 Homo sapiens (Human) TAGWEARGRR 1 6.5 0.97503 -1.4357 0 0 0 0 0 0 11.1164 0 0 0 0 0 Q5SYE7 NHSL1_HUMAN NHS-like protein 1 NHSL1 C6orf63 KIAA1357 Homo sapiens (Human) cell differentiation [GO:0030154] ANIQSLEPR;QVGSIQRSIR;QVGSIQRSIRK;SLSFSGPRYGR;TPVAPQYHLKPSAFLK;VVFINAKIKSLIK;VVPPSMR 7 4.2 0.97387 -1.397 0 0 6.72438 10.2295 0 8.46291 0 0 10.2219 0 0 10.9522 Q5SZB4 CI050_HUMAN Uncharacterized protein C9orf50 C9orf50 Homo sapiens (Human) ALYPGAK 1 1.6 0.90886 -0.31433 0 0 0 0 0 0 0 0 0 8.81727 0 0 Q5SZD1 CF141_HUMAN Uncharacterized protein C6orf141 C6orf141 Homo sapiens (Human) DAADPPK 1 2.9 0.65204 0.17022 0 0 0 0 0 7.51586 0 0 0 0 6.30787 9.54726 Q5SZD4 GLYL3_HUMAN Glycine N-acyltransferase-like protein 3 (EC 2.3.1.13) (Acyl-CoA:glycine-N-acyltransferase-like protein 3) GLYATL3 C6orf140 Homo sapiens (Human) lipid metabolic process [GO:0006629] mitochondrion [GO:0005739] glycine N-acyltransferase activity [GO:0047961] AVANSKQLNIKLTSFK;LTYLSVANADLLNRTWSR 2 11.8 0.87129 -0.095404 0 0 0 8.43563 0 0 0 10.9398 0 0 0 0 Q5SZI1 LRAD2_HUMAN Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) membrane [GO:0016020] EACCLLQLPQR;LGPCGAYFR 2 7.4 0.93388 -0.49985 9.72661 0 0 0 0 0 0 0 0 0 10.549 0 Q5SZJ8 BEND6_HUMAN BEN domain-containing protein 6 BEND6 C6orf65 Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] NLNSQDIK 1 4.4 0.91766 -0.40143 0 0 0 0 0 0 0 10.8878 0 0 0 0 Q5SZJ8 BEND6_HUMAN BEN domain-containing protein 6 BEND6 C6orf65 Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] WQNPLLQGTKL 1 5.8 0.88181 -0.16795 0 0 0 0 0 0 0 0 0 8.87191 0 0 Q5SZK8 FREM2_HUMAN FRAS1-related extracellular matrix protein 2 (ECM3 homolog) FREM2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]; embryonic digit morphogenesis [GO:0042733]; eye development [GO:0001654]; heart development [GO:0007507]; inner ear development [GO:0048839]; kidney development [GO:0001822]; morphogenesis of an epithelium [GO:0002009] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] FLDVVLKRR;LLLLLLLLLSLVSRVPAQPAAFGR;LTYQNFR;WLRYTDLDTDDR;YFYVSIGSIDIVFPDVISKGVSLKEGGK 5 2.5 0.96381 -1.2007 0 0 0 0 8.64324 8.47119 11.0368 10.7102 10.3373 11.4032 0 0 Q5SZL2 CE85L_HUMAN Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15) CEP85L C6orf204 Homo sapiens (Human) neuron migration [GO:0001764] centrosome [GO:0005813]; cytoplasm [GO:0005737]; pericentriolar material [GO:0000242] LEEKVGFSNK 1 2.5 0.88685 -0.18254 0 0 0 0 0 0 0 12.0794 0 0 0 0 Q5T011 SZT2_HUMAN KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) SZT2 C1orf84 KIAA0467 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; negative regulation of TORC1 signaling [GO:1904262]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; protein localization to lysosome [GO:0061462]; regulation of superoxide dismutase activity [GO:1901668] KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; peroxisome [GO:0005777] ATKAVYYLR;IISKAPCMVLRLGFPIGTPAPAR;LVQWQNARAHLIFCLLSQK;QNLLIFLHSPK;SETPFHSRQR;TPGGAER 6 2.3 0.94143 -0.5983 0 0 8.94854 4.39712 0 0 11.6263 0 11.1986 9.06067 0 9.26824 Q5T013 HYI_HUMAN Putative hydroxypyruvate isomerase (EC 5.3.1.22) (Endothelial cell apoptosis protein E-CE1) HYI HT036 SB156 Homo sapiens (Human) glyoxylate metabolic process [GO:0046487] hydroxypyruvate isomerase activity [GO:0008903] EGLEQAVR;MGLGAVPGRQAAFR 2 12.6 0.95389 -0.90581 0 0 0 0 0 0 0 0 0 3.28768 0 0 Q5T035 CI129_HUMAN Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) FAM120A2P C9orf129 Homo sapiens (Human) YTIYWGFR 1 4.1 0.85899 -0.081434 0 0 0 0 0 0 0 0 0 0 8.97281 0 Q5T089 MORN1_HUMAN MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) CADGSTYK 1 1.6 0.91584 -0.39033 0 0 0 0 0 6.76474 0 0 0 0 0 0 Q5T0D9 TPRGL_HUMAN Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) TPRG1L FAM79A MOVER Homo sapiens (Human) "calcineurin-NFAT signaling cascade [GO:0033173]; negative regulation of synaptic transmission [GO:0050805]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic vesicle docking [GO:0016081]" calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] calmodulin binding [GO:0005516]; identical protein binding [GO:0042802] LGYSMTR 1 2.6 0.94121 -0.60275 0 0 0 0 0 0 0 0 0 0 8.22554 0 Q5T0F9 C2D1B_HUMAN Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) CC2D1B KIAA1836 LGD1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VAALSAKRAGELDR 1 1.6 0.95572 -0.98489 0 0 0 8.91871 0 0 0 0 0 0 0 0 Q5T0J7 TEX35_HUMAN Testis-expressed protein 35 TEX35 C1orf49 Homo sapiens (Human) microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] APKEQQELRLMGK;LPLRRAPK 2 7.7 0.97299 -2.618 0 0 0 0 0 0 0 0 0 8.2465 8.6987 0 Q5T0N5 FBP1L_HUMAN Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) FNBP1L C1orf39 TOCA1 Homo sapiens (Human) autophagy [GO:0006914]; cilium assembly [GO:0060271]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; plasma membrane tubulation [GO:0097320]; positive regulation of filopodium assembly [GO:0051491]; signal transduction [GO:0007165]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase binding [GO:0051020]; lipid binding [GO:0008289] AIYPFDGHNEGTLAMK;IEIEQNYAKQLR 2 4.6 0.91831 -0.40588 0 0 0 0 0 0 7.47468 0 0 0 10.3007 0 Q5T0T0 MARH8_HUMAN E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) MARCHF8 MARCH8 MIR RNF178 Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] SSSGLAGSMGFCSDEMGDDDVFEDSTSAK;VYRSKTK 2 6.3 0.89724 -0.25249 0 0 0 8.3258 0 10.3345 7.21471 0 0 0 0 8.23487 Q5T0U0 CC122_HUMAN Coiled-coil domain-containing protein 122 CCDC122 Homo sapiens (Human) VAKQQQSQASEIEK 1 5.1 0.95215 -0.67954 0 0 12.4411 0 0 0 0 0 0 0 0 0 Q5T0W9 FA83B_HUMAN Protein FAM83B FAM83B C6orf143 Homo sapiens (Human) cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] ENLSKNKAPAFYR;VSDFLAEEEINYILK 2 2.8 0.95767 -1.0169 0 0 0 0 0 0 0 12.198 0 0 8.51503 0 Q5T0Z8 CF132_HUMAN Uncharacterized protein C6orf132 C6orf132 Homo sapiens (Human) EGKKGPR;FSGGGRSLIKK;HNWTKPEPQAPVAWER;ICENGADDDK;LEGGRICENGADDDK;LSSAAEK;NLPPQSTTLLPTTSLQPK;SPAEPKGSALGPNPEPHLTFPR;WKSDVALNGRQAEATR 9 9.4 0.97791 -5.9996 0 0 13.1574 10.0591 3.12735 0 0 0 13.4467 6.27884 11.2174 9.30823 Q5T124 UBX11_HUMAN UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5) UBXN11 SOC UBXD5 PP2243 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoskeleton [GO:0005856]; cytosol [GO:0005829] ubiquitin binding [GO:0043130] APKSSLK;MSSPLASLSKTR;TLEPIPLKLYR 3 5.8 0.96441 -1.2226 4.78759 0 0 8.74322 7.77906 0 0 0 11.9356 0 0 0 Q5T160 SYRM_HUMAN "Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS2 RARSL Homo sapiens (Human) arginyl-tRNA aminoacylation [GO:0006420]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; RNA binding [GO:0003723] IVVEFSSPNVAK;IVVEFSSPNVAKK;LLESKGLLLKTIK;NPQETAER 4 5.9 0.93386 -0.49738 9.94695 0 9.02464 0 0 0 0 0 0 7.60288 4.62 0 Q5T197 DCST1_HUMAN E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase) DCST1 Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein ubiquitination [GO:0016567]; sperm-egg recognition [GO:0035036]; ubiquitin-dependent protein catabolic process [GO:0006511] acrosomal membrane [GO:0002080]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ACSLEISLEWWSGVGLRCQR;APVFTEPQFLPLK;HIWVPLLTHLLCLPMKFKFFCGIAK 3 8.7 0.89665 -0.25047 0 0 0 0 0 0 0 0 0 0 9.1727 10.9763 Q5T1A1 DCST2_HUMAN DC-STAMP domain-containing protein 2 DCST2 Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036] acrosomal membrane [GO:0002080] QEFEFNMTATHHFSVDLNASR;QVRATVLLLLPQAFSR;SIMDGVK;VICASYYPSREQER 4 7.5 0.96475 -1.1642 0 0 6.59459 0 0 0 7.98082 8.25635 4.31839 0 0 0 Q5T1B0 AXDN1_HUMAN Axonemal dynein light chain domain-containing protein 1 AXDND1 C1orf125 Homo sapiens (Human) manchette assembly [GO:1905198]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] ARQAEEK;DIWSSATYELALKVIER 2 2.4 0.95225 -0.72325 0 0 0 0 0 0 6.51609 0 9.09344 0 0 0 Q5T1C6 THEM4_HUMAN Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) THEM4 CTMP Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] long-chain fatty acyl-CoA hydrolase activity [GO:0052816] LPGSEPRPELRSFSSEEVILK;TLGALCLPPVGR 2 13.8 0.95285 -0.67722 0 0 0 0 0 0 0 10.0137 0 0 0 7.66128 Q5T1H1 EYS_HUMAN Protein eyes shut homolog (Epidermal growth factor-like protein 10) (EGF-like protein 10) (Epidermal growth factor-like protein 11) (EGF-like protein 11) (Protein spacemaker homolog) EYS C6orf178 C6orf179 C6orf180 EGFL10 EGFL11 SPAM UNQ9424/PRO34591 Homo sapiens (Human) detection of light stimulus involved in visual perception [GO:0050908]; skeletal muscle tissue regeneration [GO:0043403] centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; interphotoreceptor matrix [GO:0033165]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509] CGNGGTCIESGTSVYCNCTTGWK;IKDVVFFQEPKNIELIK;NFTGCIEVIEINNWR;VGAEGYLDLDGINVTEK;YVCIPGCTK 5 2.6 0.95215 -0.70884 0 5.77231 0 2.18824 0 0 11.0274 0 0 12.6646 0 10.3024 Q5T1M5 FKB15_HUMAN FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) FKBP15 KIAA0674 Homo sapiens (Human) endocytosis [GO:0006897] actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; growth cone [GO:0030426]; membrane [GO:0016020] actin binding [GO:0003779]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] NQRYVEQSNLMMEKR;QNEQHIKELEKNK;RNNSLQTATENTQAK;SGEPALRTK 4 4.2 0.98029 -1.6 0 0 4.74152 0 0 0 0 9.54084 5.57945 0 12.8237 0 Q5T1N1 AKND1_HUMAN Protein AKNAD1 AKNAD1 C1orf62 Homo sapiens (Human) APHSDSTPNSDTGHSFCSDSGTEMQSNKCQDCGTK;HLTLQQQVHK;INCGRFSIVLHEK;IPKNKIINKPLAIAK;KDGLEVLNQIIFIADDPQEK;QDSPYHLQDKKLVLEK 6 13 0.97349 -2.5504 0 0 0 8.8752 10.7793 3.80199 5.20707 0 8.82547 0 9.0727 0 Q5T1R4 ZEP3_HUMAN Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) HIVEP3 KBP1 KIAA1555 KRC ZAS3 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKYVCEECGIRCK;GVIYECNICGAR;HMKSKAHSK 3 1.4 0.77396 0.046855 0 0 0 0 3.36359 0 0 0 0 0 7.25304 9.76153 Q5T1V6 DDX59_HUMAN Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) DDX59 ZNHIT5 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] SISIHSEKSQIER;TDEDVCSLECKAK;TPSALILTPTRELAIQIERQAK;VIIATPGRLLDIIK;YGEYICDKTDEDVCSLECK 5 11.3 0.96461 -1.2496 0 0 0 0 7.57001 8.36098 0 0 9.47715 3.62644 8.67455 0 Q5T200 ZC3HD_HUMAN Zinc finger CCCH domain-containing protein 13 ZC3H13 KIAA0853 Homo sapiens (Human) mRNA processing [GO:0006397]; regulation of stem cell population maintenance [GO:2000036]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DAHDYRDR;DLDRERER;DLESTSRDSLALDKER;DMRDSREMR;DQRPSSPIR;EDIKITKER;EYEQDQSSSRDHRDDR;IEEKTRDGK;LISDSVERDR;NDELERDERR;SLSPSHLTEDRQGRWK;VLHSGSRDR;YEEQELK;YPERDNRDQAR 14 8.8 0.97809 -7.9859 0 0 12.6693 0 5.61173 9.12024 11.0781 11.9369 9.75277 0 11.3564 12.1376 Q5T292 TM273_HUMAN Transmembrane protein 273 TMEM273 C10orf128 Homo sapiens (Human) membrane [GO:0016020] APRAHVLR;SLLQCHHCIMEGLFK 2 13.4 0.97444 -1.4252 0 0 0 0 10.2848 0 9.31066 0 0 0 0 0 Q5T2E6 ARMD3_HUMAN Armadillo-like helical domain-containing protein 3 ARMH3 C10orf76 Homo sapiens (Human) regulation of Golgi organization [GO:1903358] cytosol [GO:0005829]; Golgi membrane [GO:0000139] LLCYQKK;STSGFDIINMLMGFDKAELCMK;YSEQHKEAAFFK 3 6 0.97908 -2.047 0 0 0 0 0 0 13.7633 0 0 0 0 10.7507 Q5T2N8 ATD3C_HUMAN ATPase family AAA domain-containing protein 3C ATAD3C Homo sapiens (Human) mitochondrion organization [GO:0007005] mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ETSRITVLEALR;LFDWANTSR;LFDWANTSRR;LTEGMSCRK;LVRMYLNEYVLKPATEGK 5 11.9 0.95418 -0.95292 0 9.18676 0 0 0 0 0 0 0 0 0 0 Q5T2Q4 CCYL2_HUMAN Cyclin-Y-like protein 2 CCNYL2 C10orf21 Homo sapiens (Human) regulation of canonical Wnt signaling pathway [GO:0060828] plasma membrane [GO:0005886] protein kinase binding [GO:0019901] ASTIFLRKSQTDVQEK 1 4.4 0.85036 -0.075899 0 0 0 0 0 0 3.62199 0 0 0 0 0 Q5T2R2 DPS1_HUMAN All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) PDSS1 DPS1 TPRT Homo sapiens (Human) isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] heterotetrameric polyprenyl diphosphate synthase complex [GO:0032478]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; polyprenyl diphosphate synthase complex [GO:0032476] all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982] FAHYLEKTFKK;GKHTVNK;GLYEDIRK;LGWRDLK 4 8 0.9759 -4.5685 0 0 0 9.68559 0 8.62983 0 0 0 11.3524 0 0 Q5T2S8 ODAD2_HUMAN Outer dynein arm-docking complex subunit 2 (Armadillo repeat-containing protein 4) ODAD2 ARMC4 Homo sapiens (Human) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591] axoneme [GO:0005930]; ciliary base [GO:0097546] DFSLAQETCQLAIR;DQENLAVITDHGVVPLLSK;EISHNPQIR;IRSFGQLSRLLLIAK;NQINFWR 5 6.1 0.95459 -0.95585 0 0 0 0 0 0 10.9651 8.6767 10.1113 0 9.42217 8.25181 Q5T2S8 ODAD2_HUMAN Outer dynein arm-docking complex subunit 2 (Armadillo repeat-containing protein 4) ODAD2 ARMC4 Homo sapiens (Human) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591] axoneme [GO:0005930]; ciliary base [GO:0097546] DFSLAQETCQLAIR;DQENLAVITDHGVVPLLSK;EISHNPQIR;LQLVVYPISAGWLLLQRR 4 9.8 0.32411 0.24624 0 10.4081 0 0 0 0 0 0 0 0 0 0 Q5T2T1 MPP7_HUMAN MAGUK p55 subfamily member 7 MPP7 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; establishment of cell polarity [GO:0030010]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to adherens junction [GO:0071896] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; MPP7-DLG1-LIN7 complex [GO:0097025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] EAGLSFK;LETETHWVPVSWLHS;LVVLVGPVGVGLNELKRK 3 6.9 0.91574 -0.37254 0 0 0 0 0 0 5.44923 0 0 8.86177 4.4939 0 Q5T2W1 NHRF3_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) PDZK1 CAP70 NHERF3 PDZD1 Homo sapiens (Human) carnitine transport [GO:0015879]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic anion transport [GO:0044070]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102] ETDKRHVEQK;KAYDYFQAK;LLPHQPRIVEMKK;NVTLLVCGKKAYDYFQAK 4 7.9 0.96439 -1.1696 6.05806 6.85885 5.7469 9.95409 0 8.60984 0 8.27338 8.29324 5.01386 12.4467 0 Q5T2W1 NHRF3_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) PDZK1 CAP70 NHERF3 PDZD1 Homo sapiens (Human) carnitine transport [GO:0015879]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic anion transport [GO:0044070]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102] KAYDYFQAK;NVTLLVCGKKAYDYFQAK;TVQGQIIK 3 6.4 0.82891 -0.023052 0 0 11.8082 0 0 0 0 0 0 0 0 0 Q5T3F8 CSCL2_HUMAN CSC1-like protein 2 (Transmembrane protein 63B) TMEM63B C6orf110 Homo sapiens (Human) exocytosis [GO:0006887]; sensory perception of sound [GO:0007605]; surfactant secretion [GO:0160069] actin cytoskeleton [GO:0015629]; alveolar lamellar body membrane [GO:0097233]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] CQGCTCR;KVAWDYGRLALVTDADR 2 2.9 0.98126 -1.6998 0 0 0 0 0 0 0 5.53001 0 0 0 0 Q5T3I0 GPTC4_HUMAN G patch domain-containing protein 4 GPATCH4 GPATC4 Homo sapiens (Human) nucleolus [GO:0005730] RNA binding [GO:0003723] AGVSTVQK 1 1.8 0.74409 0.10231 0 0 0 0 0 0 0 13.7964 0 0 0 0 Q5T3I0 GPTC4_HUMAN G patch domain-containing protein 4 GPATCH4 GPATC4 Homo sapiens (Human) nucleolus [GO:0005730] RNA binding [GO:0003723] VGHDPAK 1 5 0.91153 -0.32121 13.6466 7.34696 0 11.4742 11.6796 0 0 0 0 12.1337 0 12.6986 Q5T3J3 LRIF1_HUMAN Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) LRIF1 C1orf103 RIF1 Homo sapiens (Human) dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of DNA-templated transcription [GO:0006355] Barr body [GO:0001740]; centriolar satellite [GO:0034451]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] nuclear retinoic acid receptor binding [GO:0042974] GAQGRNDK;RTEMEYYTHEKQEK;TEMEYYTHEKQEK 3 2.9 0.98128 -1.7036 6.32499 0 0 0 0 0 7.38905 8.94781 0 0 0 0 Q5T3U5 MRP7_HUMAN ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7) ABCC10 MRP7 SIMRP7 Homo sapiens (Human) leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; lipid transport [GO:0006869]; transmembrane transport [GO:0055085] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626] ADAVLLMEAGR;ATGATYR;AVGQGLALAILFSLLLMQATRNAADWWLSHWISQLK;FEEENLRLLELNQR;VFQAHWQEGAR 5 5.3 0.97312 -2.5912 0 6.73417 9.21045 0 0 10.268 8.27752 0 11.3023 0 0 0 Q5T3Y7 BVAS1_HUMAN Putative uncharacterized protein POPDC1-AS1 (BVES antisense RNA 1) (BVES antisense gene protein 1) POPDC1-AS1 C6orf112 Homo sapiens (Human) YISSSCVLTSILYLGEK 1 17.3 0.87161 -0.095717 0 0 0 0 0 0 0 0 0 0 0 10.4794 Q5T440 CAF17_HUMAN "Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)" IBA57 C1orf69 Homo sapiens (Human) heme biosynthetic process [GO:0006783]; iron-sulfur cluster assembly [GO:0016226] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; transferase activity [GO:0016740] AGQGNVGLALLWSEK;RKVTVEPHPELR;WRLRAAPR 3 9.8 0.97395 -3.0059 0 0 0 0 0 0 0 0 0 9.93595 0 0 Q5T442 CXG2_HUMAN Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein) GJC2 GJA12 Homo sapiens (Human) cell communication by electrical coupling [GO:0010644]; cell-cell signaling [GO:0007267]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; response to toxic substance [GO:0009636] connexin complex [GO:0005922]; gap junction [GO:0005921]; myelin sheath [GO:0043209]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; proximal neuron projection [GO:1990769] gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763] AAFEVAFLVGQYLLYGFEVRPFFPCSR 1 6.2 0.71305 0.14489 0 5.57283 0 0 0 0 0 0 0 0 0 0 Q5T447 HECD3_HUMAN E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) HECTD3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] perinuclear region of cytoplasm [GO:0048471] syntaxin binding [GO:0019905]; ubiquitin-protein transferase activity [GO:0004842] EVLYKLYK;KLTRFEDFEPSDSR;LEGTDPEVLYR;LTRFEDFEPSDSR;VGAAGPAPGTGSGPLRAAR 5 6 0.9748 -3.8567 0 0 12.6761 5.71998 9.8292 0 0 0 11.3287 8.57331 0 0 Q5T447 HECD3_HUMAN E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) HECTD3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] perinuclear region of cytoplasm [GO:0048471] syntaxin binding [GO:0019905]; ubiquitin-protein transferase activity [GO:0004842] KLTRFEDFEPSDSR;LGSWGCYRYAK;LTRFEDFEPSDSR 3 5.3 0.92142 -0.44354 12.1225 0 0 0 0 0 0 0 0 0 0 11.741 Q5T4B2 GT253_HUMAN Inactive glycosyltransferase 25 family member 3 (Cerebral endothelial cell adhesion molecule) CERCAM CEECAM1 GLT25D3 KIAA1502 Homo sapiens (Human) cell adhesion [GO:0007155]; leukocyte cell-cell adhesion [GO:0007159] endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] LSWDLIYLGRKQVNPEK;VLVFEDDVR 2 4.4 0.98039 -1.6841 10.9067 0 0 0 0 0 0 0 0 0 0 0 Q5T4D3 TMTC4_HUMAN Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4) TMTC4 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; outer hair cell apoptotic process [GO:1905584]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; protein O-linked mannosylation [GO:0035269]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ATPase binding [GO:0051117]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] ADLLCALFFLLSFLGYCKAFR;KKLIAAVVLGILFINTLR;KYPDCYYNLGR;LIAAVVLGILFINTLR;LIAAVVLGILFINTLRCVLRSGEWR 5 8 0.95923 -1.0382 0 0 7.28864 7.43421 0 0 7.9901 0 0 0 5.67861 0 Q5T4F4 ZFY27_HUMAN Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) ZFYVE27 SPG33 Homo sapiens (Human) endoplasmic reticulum tubular network formation [GO:0071787]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axon extension [GO:0045773]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; growth cone membrane [GO:0032584]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ISVPALLGYLQEVCR;RSCSNCGNSFCSR 2 9 0.87271 -0.11246 0 0 0 8.79808 0 0 0 0 0 0 0 7.33056 Q5T4S7 UBR4_HUMAN E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) UBR4 KIAA0462 KIAA1307 RBAF600 Homo sapiens (Human) cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; endosome organization [GO:0007032]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of HRI-mediated signaling [GO:0141191]; positive regulation of autophagy [GO:0010508]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AEHASSLLELASTTKCSSVK;EEALQADK;IAAGIKNNSNGHQLKDLILQK;KFLSRPALPFILRLLR;LFSYCVKVK;LIGSHTISKVTVK;NLDADIWKKFLSRPALPFILR;NNSNGHQLK;QHLAVSHEKGKITVLQLSALLK;SLTGLLSSFVEVESIKR;TVQAIVELK;VLIEFSLLR;VTISDGKVADEEKPK;YDEDHSGDDK 14 3.4 0.97507 -4.0173 7.35112 11.8556 0 5.38967 8.92564 9.51848 0 9.59891 11.594 0 7.50772 0 Q5T4T6 SYC2L_HUMAN Synaptonemal complex protein 2-like (SCP-2-like) (145 kDa nucleolar protein homolog) (hsNO145) SYCP2L C6orf177 NO145 Homo sapiens (Human) meiotic recombination checkpoint signaling [GO:0051598]; synaptonemal complex assembly [GO:0007130] "condensed chromosome, centromeric region [GO:0000779]; lateral element [GO:0000800]; nucleoplasm [GO:0005654]" EVLEFWGK;ISSELFSKSDKEDR;IVNQESLTESTSLK;NEFQSVSLLLKCIQR 4 6.3 0.95454 -0.95871 0 0 5.06549 0 0 9.64917 0 0 0 11.2852 0 6.15176 Q5T4W7 ARTN_HUMAN Artemin (Enovin) (Neublastin) ARTN EVN Homo sapiens (Human) axon guidance [GO:0007411]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; induction of positive chemotaxis [GO:0050930]; lymphocyte migration into lymphoid organs [GO:0097021]; neuroblast proliferation [GO:0007405]; peripheral nervous system development [GO:0007422]; Peyer's patch morphogenesis [GO:0061146]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] PGLISAR 1 3 0.92435 -0.45018 0 0 0 0 0 0 0 0 0 10.4839 10.7315 0 Q5T5A8 LCE3C_HUMAN Late cornified envelope protein 3C (Late envelope protein 15) (Small proline-rich-like epidermal differentiation complex protein 3A) LCE3C LEP15 SPRL3A Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640] GHGSGGCC;MSCQQNQQQCQPPPSCPSPKCPPK 2 34 0.76404 0.067771 0 4.55016 0 0 0 0 0 0 0 0 0 7.71884 Q5T5B0 LCE3E_HUMAN Late cornified envelope protein 3E (Late envelope protein 17) LCE3E LEP17 Homo sapiens (Human) keratinization [GO:0031424] GSGQQGGGSGCCHGSGGCC;SCQQNQKQCQPPPK 2 35.9 0.9165 -0.41449 0 0 2.61779 6.25826 0 0 0 4.09753 0 0 0 3.37796 Q5T5C0 STXB5_HUMAN Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) STXBP5 LLGL3 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle priming [GO:0010807] acetylcholine-gated channel complex [GO:0005892]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of neuronal dense core vesicle membrane [GO:0098674]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] DNSFSRSRSSSVTSIDK;EPEIQETLQSEHFQLCKTVR;FSKMVANDIAKMSR;LLIGFESGTVVLWDLKSK 4 6 0.97482 -3.1896 9.57467 0 0 9.73067 9.84328 0 0 0 0 0 0 7.70895 Q5T5D7 ZN684_HUMAN Zinc finger protein 684 ZNF684 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" CGKAFSQKSNLIVHQK;DNFLKSVLLTFNKILTMER;NLISVGCPITKTK 3 12.7 0.94162 -0.60199 0 0 0 5.99725 0 0 7.96093 3.53257 0 0 0 0 Q5T5F5 A4AS1_HUMAN Uncharacterized protein ADAMTSL4-AS1 (ADAMTSL4 antisense RNA 1) (ADAMTSL4 antisense gene protein 1) ADAMTSL4-AS1 C1orf138 Homo sapiens (Human) KPQSVGICVR;WLWQDIQCCPAPPSAPPR 2 21.7 0.89218 -0.21317 0 0 0 7.10434 0 0 7.74409 0 8.30323 0 10.1389 0 Q5T5J6 SWT1_HUMAN Transcriptional protein SWT1 SWT1 C1orf26 Homo sapiens (Human) nucleus [GO:0005634] HHYDHQESNDSHSR;NLRNKGLISGVK 2 2.9 0.97805 -1.5033 0 0 0 0 8.51369 0 0 0 0 3.84258 0 0 Q5T5N4 CF118_HUMAN Uncharacterized protein C6orf118 C6orf118 Homo sapiens (Human) AAAGHER;LHVFGKVFEDICNSSLIFGDLLKK 2 6.6 0.88082 -0.14933 6.31705 0 0 0 0 0 0 0 0 8.29967 0 0 Q5T5P2 SKT_HUMAN Sickle tail protein homolog KIAA1217 SKT Homo sapiens (Human) embryonic skeletal system development [GO:0048706] centrosome [GO:0005813]; cytoplasm [GO:0005737] HTLGGPR;IEVEAVRFLK;ISGLQYSIPDTENQTLNYGK;LSNGNSR;NLEFFHEDVRK;QEQPSIESTSPISR;QNLDHYNGKEFEK 7 4.2 0.97478 -2.3992 3.93923 7.44311 0 0 9.5047 0 0 8.40028 10.1843 9.62571 0 0 Q5T5S1 CC183_HUMAN Coiled-coil domain-containing protein 183 CCDC183 KIAA1984 Homo sapiens (Human) NTEENLELQMEDCEEWR;QLELEEAVLK 2 5.1 0.9111 -0.32426 0 0 0 6.20179 0 8.12815 0 0 0 0 0 0 Q5T5U3 RHG21_HUMAN Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) ARHGAP21 ARHGAP10 KIAA1424 Homo sapiens (Human) establishment of Golgi localization [GO:0051683]; Golgi localization [GO:0051645]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] AEQLPKTPRQSLSIR;DLNVISSLLK;ENVEQCHNDTKEESKK;LIECDTLSRK;LLSKDDTSPPK;LSFKHVSSLK;TPRQSLSIR;VNAETAK 8 4 0.97543 -4.2436 0 0 12.3727 5.8106 0 0 11.502 12.1396 0 8.68061 10.3517 0 Q5T5X7 BEND3_HUMAN BEN domain-containing protein 3 BEND3 KIAA1553 Homo sapiens (Human) DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183] heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] rDNA binding [GO:0000182] KLGEQYSCYGDGGKQELDPQR;LFPELFDHRK;SIYESSLSIGNFASR;SYQQQRK 4 6.3 0.96448 -1.1695 0 10.5085 0 0 9.72967 8.87504 11.1642 0 0 0 0 0 Q5T5Y3 CAMP1_HUMAN Calmodulin-regulated spectrin-associated protein 1 CAMSAP1 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604]; regulation of microtubule polymerization [GO:0031113] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] ALGLTANAR;KLQRLNSCETK;SRASLIEVDLSDLK;VNEPHKNSILEELEKCDANHYIILFR;YIGEEESAKLQEDMK 5 4.7 0.97597 -2.3278 12.8258 0 7.56125 7.68447 6.80077 11.0808 0 0 0 0 0 0 Q5T601 AGRF1_HUMAN Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19) ADGRF1 GPR110 PGR19 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; neuron projection development [GO:0031175]; regulation of lipid metabolic process [GO:0019216]; synapse assembly [GO:0007416] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LLKPPLLWSHGLIR;LLKPPLLWSHGLIRIIR;TKIWGTFKINER 3 3.2 0.96502 -1.2488 6.3611 0 0 4.21023 0 0 3.87332 0 0 0 5.71103 7.10329 Q5T653 RM02_HUMAN "Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2)" MRPL2 CGI-22 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VIGKAGR 1 2.3 0.90612 -0.27162 0 0 0 0 0 0 0 0 0 0 0 7.84536 Q5T655 CFA58_HUMAN Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) CFAP58 C10orf80 CCDC147 Homo sapiens (Human) cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; Notch signaling pathway [GO:0007219]; protein localization to motile cilium [GO:0120229]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] AVNATQKQTDLVK;EYKYEVEKLTNELQNLK;IMIHQVDELK;KEQLQKNK;LEDMRILR;LEQQLKEQK;LEQQLKEQKILNER;LTNELQNLK;NLYSKNLVEAQDEITDMKR;QEFFHMQR;SYDNEKR 11 11.9 0.97835 -6.3505 0 0 14.8781 12.5715 0 12.5319 13.0716 0 0 0 11.0139 8.97166 Q5T681 CJ062_HUMAN Uncharacterized protein C10orf62 C10orf62 Homo sapiens (Human) AIAYQHSGHLESK 1 5.8 0.89781 -0.23252 0 0 0 0 0 0 0 0 0 7.33047 0 0 Q5T6C5 AT7L2_HUMAN Ataxin-7-like protein 2 ATXN7L2 Homo sapiens (Human) GAAGHPAK;GKDGVEVEAPSR 2 2.8 0.97855 -1.9363 0 0 9.61016 7.40523 0 0 0 0 11.468 0 0 7.06523 Q5T6F2 UBAP2_HUMAN Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) UBAP2 KIAA1491 Homo sapiens (Human) regulation of gene expression [GO:0010468] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932] cadherin binding [GO:0045296]; RNA binding [GO:0003723] SEKESSRGR;SQPEPSPVLSQLSQR;SQPSSLQPK 3 2.9 0.93454 -0.50357 0 0 8.10554 9.7498 0 0 0 0 0 0 0 0 Q5T6J7 GNTK_HUMAN Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) IDNK C9orf103 Homo sapiens (Human) D-gluconate catabolic process [GO:0046177] ATP binding [GO:0005524]; gluconokinase activity [GO:0046316] FYDADDYHPEENRR 1 7.5 0.65312 0.1701 0 0 0 0 0 0 0 0 0 0 5.33239 0 Q5T6L9 EMARD_HUMAN Endoplasmic reticulum membrane-associated RNA degradation protein (ER membrane-associated RNA degradation protein) ERMARD C6orf70 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] QNYLRMWSSIR;SAFILKIMLPYWEVALVK 2 4.3 0.92864 -0.47222 0 0 0 0 0 0 10.6632 7.64983 0 0 0 0 Q5T6M2 CF122_HUMAN Putative uncharacterized protein encoded by LINC00242 LINC00242 C6orf122 NCRNA00242 Homo sapiens (Human) HPVPRQRK 1 3.9 0.97774 -1.5134 0 0 12.4561 0 0 0 0 0 0 0 0 0 Q5T6R2 TPT2L_HUMAN "Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1" TPTE2P1 Homo sapiens (Human) QSLPLPGLRGSPVER 1 13.9 0.91601 -0.4323 0 0 0 0 0 0 0 10.0088 0 0 0 0 Q5T6S3 PHF19_HUMAN PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) PHF19 PCL3 Homo sapiens (Human) "negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]" ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] LTSTPVTDR;YQVLARRVTPEGK 2 3.8 0.97839 -2.1496 0 0 9.45311 0 0 0 0 0 0 0 0 0 Q5T6V5 QNG1_HUMAN Queuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Q-nucleotide N-glycosylase 1) (Queuine salvage protein QNG1) (Queuosine-nucleotide N-glycosylase/hydrolase) QNG1 C9orf64 Homo sapiens (Human) nucleoside salvage [GO:0043174]; tRNA-guanine transglycosylation [GO:0101030] hydrolase activity [GO:0016787] MDGLLNPR 1 2.3 0.01378 0.79781 0 0 0 0 0 0 0 0 0 0 9.50202 0 Q5T6X5 GPC6A_HUMAN G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33) GPRC6A Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; regulation of testosterone biosynthetic process [GO:2000224]; response to amino acid [GO:0043200] cell surface [GO:0009986]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CSKECSPGQMKK;FLSKFNCSR;TLKKIILEAQLLGVLK 3 4.9 0.97486 -1.4276 0 0 0 4.15607 0 3.67649 5.33181 0 0 0 11.7213 0 Q5T749 KPRP_HUMAN Keratinocyte proline-rich protein (hKPRP) KPRP C1orf45 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] CPRRPISSCSQRR 1 2.2 0.86845 -0.093886 0 0 0 8.03276 0 0 0 0 0 0 0 0 Q5T754 LCE1F_HUMAN Late cornified envelope protein 1F (Late envelope protein 6) LCE1F LEP6 Homo sapiens (Human) keratinization [GO:0031424] identical protein binding [GO:0042802] RSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC 1 29.7 0.4142 0.19995 0 0 0 0 0 0 0 0 0 4.52888 0 0 Q5T764 IFT1B_HUMAN Interferon-induced protein with tetratricopeptide repeats 1B (Interferon-induced protein with tetratricopeptide repeats 1-like protein) IFIT1B IFIT1L Homo sapiens (Human) defense response to virus [GO:0051607] cytosol [GO:0005829] RNA binding [GO:0003723] AKTCFEK;IEKMSHSR 2 3.2 0.98131 -1.7762 0 11.348 0 8.18859 0 0 0 0 0 0 0 0 Q5T7B8 KIF24_HUMAN Kinesin-like protein KIF24 KIF24 C9orf48 Homo sapiens (Human) cilium assembly [GO:0060271]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; negative regulation of cilium assembly [GO:1902018] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DSDRQTK;ETLLVHEKK;GPVDWSRENSTSSGPSPR;LFAREDSK;LGWQEFGLSTDPIK;LTQVLKDSFIGNAK 6 5.1 0.97608 -5.0541 8.56217 0 0 8.97304 9.61021 0 0 0 0 11.2287 0 0 Q5T7M9 DIK1A_HUMAN Divergent protein kinase domain 1A (Protein FAM69A) DIPK1A FAM69A Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] AKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDK;IVPETNLK;MARSLCPGAWLR 3 13.3 0.95414 -0.92015 12.8354 0 12.3295 0 0 0 10.8478 10.6071 5.1686 12.4618 12.5808 12.0706 Q5T7N2 LITD1_HUMAN LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11) L1TD1 ECAT11 Homo sapiens (Human) retrotransposition [GO:0032197] intracellular membrane-bounded organelle [GO:0043231]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] EADLTEETEENLR;ENITYMKR;IDEKRLTPR;TTSLTEK;VAKPEEMK;YGIQEKR 6 6 0.98032 -1.6841 12.3593 8.30579 0 8.00439 0 9.29239 0 6.51164 0 9.1282 6.49689 0 Q5T7N3 KANK4_HUMAN KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) KANK4 ANKRD38 Homo sapiens (Human) negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] AHAEQGR;GAGGFLWGSDR;KTPPAGR;QSLNTISQEWFR;SIGIRVTEESLGLAR 5 5.2 0.98134 -1.7632 0 11.4743 0 0 7.108 7.85125 0 0 0 0 0 8.99741 Q5T7N8 F27D1_HUMAN Protein FAM27D1 FAM27D1 Homo sapiens (Human) GPGLHRAK;GTQADLSSRSRMAAR;LTPTNTVR;THTHTGMHTQTHR 4 20.5 0.9758 -2.3096 0 0 0 0 0 0 0 11.7006 8.47054 2.36174 0 0 Q5T7P6 TMM78_HUMAN Transmembrane protein 78 TMEM78 Homo sapiens (Human) membrane [GO:0016020] QGLALSPR 1 5.9 0.91339 -0.39033 0 0 0 0 0 0 0 0 0 9.63043 0 0 Q5T7V8 GORAB_HUMAN RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) GORAB NTKLBP1 SCYL1BP1 Homo sapiens (Human) hair follicle morphogenesis [GO:0031069]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] KSRQQLQR 1 2.2 0.87035 -0.095167 0 0 0 0 0 0 11.8472 0 11.4554 0 0 0 Q5T7W0 ZN618_HUMAN Zinc finger protein 618 ZNF618 KIAA1952 Homo sapiens (Human) positive regulation of chromatin binding [GO:0035563] chromatin [GO:0000785]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator binding [GO:0001221] ENFKVHPAHK;IGPMNNITSDIFK 2 2.7 0.83812 -0.037095 0 0 0 0 0 0 0 0 0 0 0 11.3592 Q5T7W0 ZN618_HUMAN Zinc finger protein 618 ZNF618 KIAA1952 Homo sapiens (Human) positive regulation of chromatin binding [GO:0035563] chromatin [GO:0000785]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator binding [GO:0001221] APASVVR;ATAESAFSRR;ENFKVHPAHK 3 2.9 0.97283 -2.6639 6.87639 0 0 0 0 0 0 0 0 9.76326 0 0 Q5T7W7 TSTD2_HUMAN Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) TSTD2 C9orf97 PP4189 Homo sapiens (Human) EKLWKCCR;FSDLDLK;LFVFDER;VLMYCTGGIR;YLEEFPDGFYKGKLFVFDER 5 8.7 0.9785 -2.0601 10.2253 0 0 0 0 0 9.77538 0 0 0 0 0 Q5T848 MGLYR_HUMAN Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) GPR158 KIAA1136 Homo sapiens (Human) brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807] cell projection [GO:0042995]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888] EGADHGTAK;SASAHNLSSEKK;SIMRRITEIPETVSR 3 3 0.9555 -0.88112 6.55818 14.0478 0 0 0 0 0 6.76062 0 0 0 0 Q5T871 LELP1_HUMAN Late cornified envelope-like proline-rich protein 1 (Novel small proline-rich protein) LELP1 Homo sapiens (Human) CEQKCESK 1 8.2 0.91446 -0.33804 0 0 0 0 0 9.82394 0 0 0 0 0 0 Q5T890 ER6L2_HUMAN DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) (DNA repair and recombination protein RAD26-like) ERCC6L2 C9orf102 RAD26L Homo sapiens (Human) cellular response to reactive oxygen species [GO:0034614]; interstrand cross-link repair [GO:0036297] centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901] DILEREGQVEAGIMTATTWLK;ILEQNISSK;LSPENTTLK;NLIFDDEDLEKPYFPNR;SLNSESETR;VLLFSFSTK 6 4.8 0.9804 -1.869 12.6295 0 0 9.46011 0 0 0 9.93229 10.0745 8.62183 0 0 Q5T8A7 PPR26_HUMAN Protein phosphatase 1 regulatory subunit 26 PPP1R26 KIAA0649 Homo sapiens (Human) nucleolus [GO:0005730] protein phosphatase inhibitor activity [GO:0004864] AEGCHDARPAAKPTVHK;AEPGHER;AKSGAAQPGAGGAQPGAAQPSRAAGGGSR;EERAPDPPAHSTSSATK;MSQGQGK 5 6.4 0.97883 -2.112 0 12.1566 0 0 0 0 8.74403 0 0 0 8.29398 0 Q5T8D3 ACBD5_HUMAN Acyl-CoA-binding domain-containing protein 5 ACBD5 KIAA1996 Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; pexophagy [GO:0000425] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] fatty-acyl-CoA binding [GO:0000062] NLEVIVTNGYDK 1 2.2 0.77725 0.041127 0 0 0 0 0 0 0 0 0 7.11114 0 0 Q5T8I3 EEIG2_HUMAN EEIG family member 2 (EEIG2) EEIG2 FAM102B Homo sapiens (Human) EDTASEKLSRCPVK;EVVQANCVRWRK;LSRCPVK;VLISMQLMSGDPCFK 4 11.4 0.97988 -1.8394 12.3486 0 0 0 0 0 9.41964 0 0 0 6.23153 0 Q5T8P6 RBM26_HUMAN RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) RBM26 C13orf10 PRO1777 Homo sapiens (Human) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] CRDYDEK;IVVDSESR;LFDAVNTK;TLEVLTKNITKLK 4 3.6 0.97782 -1.9496 0 11.0677 0 0 0 0 0 7.51396 7.79727 0 0 0 Q5T8R8 DOAS1_HUMAN Uncharacterized protein DOCK8-AS1 (DOCK8 antisense RNA 1) DOCK8-AS1 C9orf66 Homo sapiens (Human) AGSGGRGGR;GARADDRRPLR;LPGNVGK;LPRRLSPFWDPATCK 4 14.2 0.97255 -2.7551 0 0 7.68615 0 0 9.53384 9.23752 6.29954 0 0 0 0 Q5T9A4 ATD3B_HUMAN ATPase family AAA domain-containing protein 3B (AAA-TOB3) ATAD3B KIAA1273 TOB3 Homo sapiens (Human) mitochondrion organization [GO:0007005] ficolin-1-rich granule membrane [GO:0101003]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] QGWQVAERQHVGASWSPR 1 10.8 0.81248 -0.015229 0 0 0 0 6.1173 0 0 0 0 0 0 0 Q5T9C2 EEIG1_HUMAN Early estrogen-induced gene 1 protein (EEIG1) EEIG1 C9orf132 FAM102A Homo sapiens (Human) positive regulation of osteoclast differentiation [GO:0045672] cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634] LLDGGDFVSLSSR 1 3.4 0.78982 0.016991 0 0 0 0 0 0 0 11.6245 0 0 0 0 Q5T9C9 PI5L1_HUMAN Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68) PIP5KL1 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of apoptotic process [GO:0043065] cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] YARRLCQWVEAHTE;YVQHLQR 2 5.3 0.98076 -1.6045 0 0 0 0 0 0 0 11.671 0 10.8168 0 0 Q5T9G4 ARM12_HUMAN Armadillo repeat-containing protein 12 ARMC12 C6orf81 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; positive regulation of cell growth [GO:0030307]; sperm mitochondrial sheath assembly [GO:0120317] mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ARPSSCQPSR;LLNNLPLPDYVHPQLRR;LSEGRNAPHYHVVK 3 12.1 0.94437 -0.64063 0 0 0 7.41811 0 0 0 8.0713 4.99444 0 0 0 Q5T9S5 CCD18_HUMAN Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) CCDC18 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] EIERTQQR;ENMKKDEALK;FESIHFELTQSRAK;LEQELQKQR;LESELENKDEILR;LSSELEDMK;LVISELRIKLAIK;NAELEQELMEK;NLTNCEKENK;VLREAENK 10 7.2 0.97815 -8.207 0 0 12.553 6.90533 0 9.07906 11.8367 12.0713 11.3125 9.77096 0 0 Q5TA45 INT11_HUMAN Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) INTS11 CPSF3L RC68 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA endonuclease activity [GO:0004521] GIMQLVGQAEPESVLLVHGEAKK;TFVQRNMFEFKHIK;VHLHDTRKEQETALR;VPIYFSTGLTEKANHYYK 4 11.7 0.9551 -0.79276 0 0 0 0 8.16511 0 6.71548 9.77228 0 0 0 10.9572 Q5TA78 LCE4A_HUMAN Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A) LCE4A LEP8 SPRL4A Homo sapiens (Human) keratinization [GO:0031424] identical protein binding [GO:0042802] SSNCYGSGSGQQSGGSGCCSGGGCC 1 25.3 0.81129 0.0037449 0 0 0 0 0 0 0 8.68113 0 0 0 0 Q5TA81 LCE2C_HUMAN Late cornified envelope protein 2C (Late envelope protein 11) LCE2C LEP11 Homo sapiens (Human) keratinization [GO:0031424] identical protein binding [GO:0042802] HQSPDCCESEPSGGSGCCHSSGGCC;RHQSPDCCESEPSGGSGCCHSSGGCC 2 23.6 0.089645 0.37531 0 6.95861 0 0 5.3927 0 0 0 0 0 0 0 Q5TAA0 TTC22_HUMAN Tetratricopeptide repeat protein 22 (TPR repeat protein 22) TTC22 Homo sapiens (Human) NQPPILNR;SEDPRHR 2 2.6 0.97678 -2.279 0 0 0 0 0 0 9.34981 0 0 0 0 0 Q5TAH2 SL9C2_HUMAN Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2) SLC9C2 SLC9A11 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] plasma membrane [GO:0005886] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] GIIDKHEVIEINK;GIIDKHEVIEINKVLLK;HEVIEINKVLLKK;IIRFLPLFK;IIRFLPLFKIIVPILIR;ILTNVNWTLVEDKTR;VLLKKLK 7 4.6 0.92876 -0.4704 5.34312 11.2573 8.75041 0 4.09871 7.54959 0 12.6488 0 6.79533 0 0 Q5TAQ9 DCAF8_HUMAN DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) DCAF8 H326 WDR42A Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DSDSMEDTGHYSINDENR 1 3 0.67555 0.16628 0 6.08332 0 6.63946 0 0 0 0 6.82375 0 0 0 Q5TAT6 CODA1_HUMAN Collagen alpha-1(XIII) chain (COLXIIIA1) COL13A1 Homo sapiens (Human) cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; morphogenesis of a branching structure [GO:0001763]; skeletal system development [GO:0001501] cell-cell junction [GO:0005911]; collagen type XIII trimer [GO:0005600]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201] DGPPGVK;LLPLLNSVRLAPPPVIKR 2 3.5 0.87438 -0.10625 0 0 0 0 0 9.23165 0 0 0 0 0 0 Q5TAX3 TUT4_HUMAN Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) TUT4 KIAA0191 ZCCHC11 Homo sapiens (Human) miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730] miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270] KDGHSKNDCPEDFR;KELSQCNCIDLSK;LCLIHIENIQGAHKHIKEK;LERDHIFR;NKQNDICIEK;SCKVNAANLPGPKDLGLVLR;SSDVNIDIKFPPK;VLTDGELAPNDR 8 6.6 0.97847 -2.0763 0 6.41978 11.3412 0 0 0 5.44959 11.5942 0 11.5817 0 0 Q5TB30 DEP1A_HUMAN DEP domain-containing protein 1A DEPDC1 DEPDC1A Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634]; transcription repressor complex [GO:0017053] GTPase activator activity [GO:0005096] GVVILQNK;KMQLVNLR;QVIPQYIMYNMANTSKR;SLMIHTFSR;STECLLLSLLHR 5 6.7 0.9649 -1.1688 11.89 7.53737 7.51924 0 0 0 10.3328 11.2727 0 0 0 0 Q5TB80 CE162_HUMAN Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) CEP162 C6orf84 KIAA1009 QN1 Homo sapiens (Human) cilium assembly [GO:0060271] axonemal microtubule [GO:0005879]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spindle [GO:0005819] GREEMSAK;ILEETHK;ILEETHKQEISR;MFSTLEKK;QESLVVSEVR;TESCLSTRKK 6 3.4 0.97613 -5.2372 0 0 0 0 0 0 0 0 0 0 0 11.4363 Q5TBA9 FRY_HUMAN Protein furry homolog FRY C13orf14 Homo sapiens (Human) cell morphogenesis [GO:0000902]; negative regulation of tubulin deacetylation [GO:1904428]; neuron projection development [GO:0031175] cell cortex [GO:0005938]; centrosome [GO:0005813]; site of polarized growth [GO:0030427]; spindle pole [GO:0000922] enzyme inhibitor activity [GO:0004857] AIGTPSVGVLLK;EGDVTASHGLR;EVGRCMMLTNVQMLNK;FSVLELQEYLDTYNNR;IIQFIAQER;KLSVLILK;LMELNMEIRDMIRR;NKDPKMAR 8 3.1 0.97317 -2.9414 0 0 11.8051 9.03681 9.17225 0 0 0 10.0868 0 8.62121 10.1182 Q5TBB1 RNH2B_HUMAN Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) RNASEH2B DLEU8 Homo sapiens (Human) fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; mismatch repair [GO:0006298]; negative regulation of gene expression [GO:0010629]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of DNA damage checkpoint [GO:2000001]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; ribonucleotide metabolic process [GO:0009259]; RNA catabolic process [GO:0006401] nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299] EDYTKFNTK;TLKWLEK 2 5.1 0.97225 -2.8212 8.8255 0 0 0 0 0 0 0 0 0 0 0 Q5TBK1 N42L1_HUMAN NEDD4-binding protein 2-like 1 N4BP2L1 CG081 Homo sapiens (Human) ALIFSTDDFFFR;NLFRLEMDMVVFRPEMK 2 16.8 0.95404 -0.91971 13.1499 11.5223 0 9.32544 0 9.29207 0 0 10.1861 0 0 0 Q5TC12 ATPF1_HUMAN ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) ATPAF1 ATP11 Homo sapiens (Human) mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] protein-containing complex stabilizing activity [GO:0140777] FDLIWNR;GFTKDKTLSSIFNIEMVK;QPVGHSR 3 9.8 0.89245 -0.22332 0 0 0 0 0 7.1632 0 10.076 9.57647 0 0 0 Q5TC63 GRTP1_HUMAN Growth hormone-regulated TBC protein 1 (TBC1 domain family member 6) GRTP1 TBC1D6 Homo sapiens (Human) GTPase activator activity [GO:0005096] GVPLEHR;IIFRVALTLIK 2 5.4 0.95256 -0.76755 0 0 0 0 7.86586 0 3.2882 0 0 0 0 0 Q5TC79 ZBT37_HUMAN Zinc finger and BTB domain-containing protein 37 ZBTB37 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GGRSDDEVRVLGAVHIK 1 3.4 0.95829 -1.0156 0 0 0 0 0 0 9.51598 0 0 0 0 0 Q5TC82 RC3H1_HUMAN Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) RC3H1 KIAA2025 RNF198 Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; P-body assembly [GO:0033962]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-transcriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of germinal center formation [GO:0002634]; regulation of miRNA metabolic process [GO:2000628]; regulation of mRNA stability [GO:0043488]; regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900151]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] CCR4-NOT complex binding [GO:1905762]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EIMAQLEER;ELSMENQCSLDMKSK;VPAEDLTLTFSSDVPNGSALTQENISLLSNK 3 4.9 0.91257 -0.32847 0 10.7069 0 4.56078 5.28014 0 0 0 0 0 0 0 Q5TC84 OGRL1_HUMAN Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) membrane [GO:0016020] opioid growth factor receptor activity [GO:0140625] FILHEALVENTIPNIK 1 3.5 0.59945 0.17734 0 0 0 0 0 0 0 0 0 0 0 7.08884 Q5TCH4 CP4AM_HUMAN Cytochrome P450 4A22 (CYPIVA22) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4A22 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]; lipid hydroxylation [GO:0002933] endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] 16-hydroxypalmitate dehydrogenase activity [GO:0103002]; alkane 1-monooxygenase activity [GO:0018685]; arachidonate monooxygenase activity [GO:0008391]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981] AAQLYLHRQWLLK;AQLQKEGELEK;GIMVLLSIYGLHHNPKVWPNLEVFDPSR;VILGRSDPK 4 11.8 0.98041 -1.6704 0 0 0 0 0 0 0 0 10.2048 0 0 0 Q5TCQ9 MAGI3_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)" MAGI3 KIAA1634 Homo sapiens (Human) apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] IEGSKAPSNAEAKLLEGK;MDSSLPEEEEDEDK;STMGFGFTIIGGDRPDEFLQVK;TIPCTTRAPR;TLITPGPWK 5 4.9 0.94487 -0.64581 0 0 7.71864 3.44188 8.35544 0 8.69676 0 0 4.02219 0 0 Q5TCS8 KAD9_HUMAN Adenylate kinase 9 (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] (deoxy)adenylate kinase activity [GO:0047506]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145] AACIDKLCITPQELLSR;EAQKDGK;EKLQKFLR;FMKNPIK;FPKCAELQGYCPVTYK;FPKCAELQGYCPVTYKDGNQR;GHYYKMSSQEK;IYYFSSAEAKEK;LPYPLHNSAQIVAVNNVK;NLNLKPDVIINIKCPDYDLCQR;TMCGRQLAEK;YIRQPKPKPTVPIRIIIVGPPK 12 8.1 0.97679 -5.5864 0 0 10.7119 0 10.0791 8.3608 11.2066 11.5039 9.09782 6.91731 11.215 0 Q5TCX8 M3K21_HUMAN Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) MAP3K21 KIAA1804 MLK4 Homo sapiens (Human) protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] ALAAANAAPDPR;AQAAEEPLPKEEKK;KPKQIKLPSQAYIDLPLGK;LRAIQLTSDESNK;QEEFEDVK 5 6.4 0.97452 -3.0567 0 0 0 6.12062 0 0 0 7.23372 0 0 0 0 Q5TCY1 TTBK1_HUMAN Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) TTBK1 BDTK KIAA1855 Homo sapiens (Human) learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] RDLSDYRER;SPRLPASTSAARNASASPR;VATISPR;VATISPRR 4 2.7 0.98094 -1.6935 0 0 0 0 10.1202 9.62024 0 0 0 0 0 9.79513 Q5TCY1 TTBK1_HUMAN Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) TTBK1 BDTK KIAA1855 Homo sapiens (Human) learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] FPHSAQPLG 1 1.4 0.60651 0.17631 0 9.89086 0 0 0 0 0 0 0 0 0 0 Q5TCZ1 SPD2A_HUMAN SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) SH3PXD2A FISH KIAA0418 SH3MD1 TKS5 Homo sapiens (Human) in utero embryonic development [GO:0001701]; osteoclast fusion [GO:0072675]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; podosome [GO:0002102] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protease binding [GO:0002020]; superoxide-generating NADPH oxidase activator activity [GO:0016176]" FPIEGGQKDPK;FPIEGGQKDPKQR;RLKPIDEYCRALVR;SAAAEAK 4 3 0.87338 -0.11131 6.51957 0 0 0 0 0 9.7233 0 9.11785 6.9438 0 0 Q5TD94 RSH4A_HUMAN Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) RSPH4A RSHL3 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; maintenance of ciliary planar beating movement pattern [GO:0120221]; radial spoke assembly [GO:0062177] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke head [GO:0001535]; radial spoke head 1 [GO:0120336]; radial spoke head 2 [GO:0120337]; radial spoke head 3 [GO:0120338] APQAIPK;FFTGRLDAPIISYPPFPGNESNYLR;NEEEEEEEDEEK 3 6.1 0.72736 0.12734 0 0 0 0 6.95768 0 0 0 0 0 5.7807 8.62033 Q5TD97 FHL5_HUMAN Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis) FHL5 ACT Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634]; Z disc [GO:0030018] metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] DDSPYCVTCYDR;DLCYKDRHWHEGCFK 2 9.5 0.42677 0.19608 0 0 0 4.11811 0 0 0 0 0 0 0 5.72552 Q5TDH0 DDI2_HUMAN Protein DDI1 homolog 2 (EC 3.4.23.-) DDI2 Homo sapiens (Human) cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; protein processing [GO:0016485]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]; ubiquitin binding [GO:0043130] LAYGAGR;LVDRRWAGIAK 2 4.5 0.98035 -1.8082 0 0 0 0 7.66455 7.06673 0 7.37417 0 11.8233 11.835 0 Q5TDP6 LGSN_HUMAN Lengsin (Glutamate-ammonia ligase domain-containing protein 1) (Lens glutamine synthase-like) LGSN GLULD1 LGS Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] TIPAHFFQEK;WLAGLLKHSAALSCLMAPSVSCRK;YELENEEIAAER 3 9 0.92087 -0.44407 0 0 0 7.81679 9.76823 0 0 11.6782 10.7616 0 0 10.26 Q5TEA3 DAAF9_HUMAN Dynein axonemal assembly factor 9 (DNAAF9) DNAAF9 C20orf194 Homo sapiens (Human) EDSIKDWLR;QGLPRAR 2 1.4 0.97302 -2.9168 0 0 0 0 0 0 10.7312 0 0 0 0 0 Q5TEA6 SE1L2_HUMAN Protein sel-1 homolog 2 (Suppressor of lin-12-like protein 2) (Sel-1L2) SEL1L2 C20orf50 Homo sapiens (Human) ERAD pathway [GO:0036503] cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789] GVPLNYAEALKYFQKAAEK;KPLSLLIEILIILGVTIK;KPLSLLIEILIILGVTIKTIK;LDNTIGPHWDLFVIGLIVPGLILLLR;TIKAEEHNK 5 10.5 0.95581 -0.87076 0 5.64985 9.38271 0 0 0 0 3.42196 0 0 3.94645 0 Q5TEC3 ZN697_HUMAN Zinc finger protein 697 ZNF697 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDDDESAGENR;GMGSDFEDSEDR;NSHLVNHLRVHTGEKPFR 3 7.5 0.94614 -0.65179 0 0 0 0 0 4.56925 0 10.3833 0 6.27895 0 0 Q5TEU4 NDUF5_HUMAN "Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-)" NDUFAF5 C20orf7 Homo sapiens (Human) methylation [GO:0032259]; mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine hydroxylation [GO:0030961] matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] GYIAQYLNK;IADRVYDIPR;LQLFHCRK 3 8.5 0.98045 -1.6815 0 0 0 10.2096 0 0 0 0 0 0 0 0 Q5TEZ4 CF164_HUMAN Putative uncharacterized protein encoded by LINC01590 (Long intergenic non-protein coding RNA 1590) LINC01590 C6orf164 Homo sapiens (Human) DHDPEVLTRNSACKPR;DHDPEVLTRNSACKPRGQLSGHLLKPR 2 35.5 0.97295 -2.6617 0 0 0 0 0 0 0 7.51586 0 9.32249 0 0 Q5TEZ5 CF163_HUMAN Uncharacterized protein C6orf163 C6orf163 Homo sapiens (Human) QLGIMTNWK 1 2.7 0.93678 -0.52665 0 0 8.22472 0 0 0 0 0 0 0 0 0 Q5TF21 MTCL3_HUMAN Microtubule cross-linking factor 3 MTCL3 C6orf174 SOGA3 Homo sapiens (Human) regulation of autophagy [GO:0010506] extracellular space [GO:0005615]; membrane [GO:0016020] DIRSEAER;ITAELNKYKYK;LHHELENVEEK;LRLVEEEANILGRK;TGPPASIR 5 5.5 0.97459 -3.4821 9.92192 0 0 0 0 9.08818 10.5397 0 0 0 0 7.36912 Q5TF39 MFS4B_HUMAN Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) MFSD4B KIAA1919 NAGLT1 HSPC100 Homo sapiens (Human) sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324] D-glucose transmembrane transporter activity [GO:0055056]; symporter activity [GO:0015293] ASAETFRR;ASAETFRRAK 2 1.9 0.95331 -0.77828 0 0 0 0 9.80384 0 0 0 0 0 0 0 Q5TFE4 NT5D1_HUMAN 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] DIVAAIQHNYK;GLALDLEDGNFLK;YLHSCPESVK 3 7.5 0.95538 -0.81538 0 0 0 0 0 0 0 0 8.45459 9.94265 0 0 Q5TG30 RHG40_HUMAN Rho GTPase-activating protein 40 (Rho-type GTPase-activating protein 40) ARHGAP40 C20orf95 Homo sapiens (Human) regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] GLDMEGILR;IQVVWPIKDPLKVPLTPSTK 2 4.3 0.96627 -1.2747 0 4.63761 6.11232 0 0 0 0 14.056 0 0 0 0 Q5TGI0 FAXC_HUMAN Failed axon connections homolog FAXC C6orf168 Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020] TLYLTGGALLAAAAYLLHELLVIR 1 5.9 0.70971 0.15634 0 0 0 0 0 7.21762 0 0 0 0 0 0 Q5TGI4 SAMD5_HUMAN Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) SAMD5 SAMDC1 Homo sapiens (Human) regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737] KVPMAGILEYLMNWPK;SRELVSYPK 2 14.5 0.98105 -1.7839 0 0 0 0 0 0 10.9651 0 0 0 0 0 Q5TGL8 PXDC1_HUMAN PX domain-containing protein 1 PXDC1 C6orf145 Homo sapiens (Human) phosphatidylinositol binding [GO:0035091] SEVVLTFFERSPLDQVLK;SPLDQVLK;TIISMPCK;TIISMPCKYSR 4 12.6 0.97422 -2.4113 6.09085 0 0 0 0 0 0 9.89801 0 8.15086 0 10.6845 Q5TGP6 MROH9_HUMAN Maestro heat-like repeat-containing protein family member 9 MROH9 C1orf129 Homo sapiens (Human) ALYAQDALR;ICTSQLKWSTSR;RSEDTVIVLIFLTELLNNFFK;VAEACKYTLKICTSQLK 4 6 0.91223 -0.32829 11.665 0 0 0 0 0 0 9.00298 6.38602 0 0 9.25404 Q5TGU0 TSPO2_HUMAN Translocator protein 2 (Peripheral-type benzodiazepine receptor-like protein 1) TSPO2 BZRPL1 Homo sapiens (Human) 5-aminolevulinic acid import across plasma membrane [GO:0140484]; enucleate erythrocyte differentiation [GO:0043353]; import across plasma membrane [GO:0098739]; intracellular cholesterol transport [GO:0032367]; lipid droplet organization [GO:0034389] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] 5-aminolevulinic acid transmembrane transporter activity [GO:0140485]; cholesterol binding [GO:0015485] RLQGAIFVLLPHLGPILVWLFTR 1 13.5 0.66783 0.16861 0 0 0 0 0 0 0 0 0 6.49817 0 0 Q5TGY1 TMCO4_HUMAN Transmembrane and coiled-coil domain-containing protein 4 TMCO4 Homo sapiens (Human) membrane [GO:0016020] HWEPFRK;VAGLQPVLLQDRR 2 3.2 0.92557 -0.45146 0 0 10.5749 0 0 8.08343 0 0 0 0 0 0 Q5TGY3 AHDC1_HUMAN Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) AHDC1 Homo sapiens (Human) cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; skin morphogenesis [GO:0043589] chromosome [GO:0005694]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; promoter-enhancer loop anchoring activity [GO:0140585] AGGFGGR;TEAACLSAPHLASPPATPK 2 1.6 0.44245 0.194 0 8.56594 0 0 0 0 0 0 11.9159 0 0 0 Q5TGZ0 MIC10_HUMAN MICOS complex subunit MIC10 (Mitochondrial inner membrane organizing system protein 1) MICOS10 C1orf151 MIC10 MINOS1 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] CLADAVVK 1 10.3 0.78095 0.03296 0 0 0 0 0 0 0 0 0 10.4821 0 0 Q5TH69 BIG3_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) ARFGEF3 BIG3 C6orf92 KIAA1244 Homo sapiens (Human) regulation of ARF protein signal transduction [GO:0032012] transport vesicle membrane [GO:0030658] guanyl-nucleotide exchange factor activity [GO:0005085] EFDTSPGLK;GLAFILGAEGIKEQNQK;GRASDFR;LLSEERFVSMETDSDEK;LSHGDYYRK;SHTVPYPDITNFLSVDCR;YILVGCWK 7 3.9 0.9724 -2.8321 0 8.75379 3.08907 0 7.68643 0 0 0 0 0 9.42608 0 Q5THJ4 VP13D_HUMAN Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) VPS13D KIAA0453 Homo sapiens (Human) lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; positive regulation of mitophagy [GO:1901526]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] ELVHDRFHK;EWWYFALNANLYEIREQRK;FEDAVINLDPFTRVHPYETK;GLGVFFCK;LNLQLQRGTVTLLHK;LPLDLKALKSTLGFPLIR;LSQEINYAK;MLLTNTQDNSRRK;NNSFHINMR;NPAHSHFER;SEFVPSTSTK;SINLVSHSMMAFDTR;VFGTNAHFVK 13 3.7 0.97614 -5.0418 6.37605 11.2096 10.2635 4.55004 0 0 0 3.24885 9.3206 0 13.7074 13.3123 Q5THK1 PR14L_HUMAN Protein PRR14L (Proline rich 14-like protein) PRR14L C22orf30 Homo sapiens (Human) LHHPLRKDTESCTSPCLLGAPR;LLVLCWYLPGWRAGRVTWLR;QEKLAFQEDSR;QPHRTCKK;SSCKVSYTSQER 5 3.4 0.97673 -5.5952 7.07489 0 0 12.1451 0 0 0 10.0028 0 0 12.7252 8.27608 Q5THR3 EFCB6_HUMAN EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; nucleoplasm [GO:0005654]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] EAGAETPSFYSALLR;GGGNEMNCCR;MKEAGAETPSFYSALLR;TFKSYDEAGTGLLSVADFR 4 3.1 0.89778 -0.2464 0 4.75606 0 0 0 0 0 0 0 0 0 0 Q5THR3 EFCB6_HUMAN EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; nucleoplasm [GO:0005654]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] EAGAETPSFYSALLR;MGHFTKPQQLQEEMKELQQSTEK;MKEAGAETPSFYSALLR;TFKSYDEAGTGLLSVADFR 4 10.4 0.95982 -1.0448 13.079 0 12.1313 0 0 0 0 0 6.31085 0 8.38948 0 Q5TID7 CC181_HUMAN Coiled-coil domain-containing protein 181 CCDC181 C1orf114 Homo sapiens (Human) cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] GNGKSNHR 1 1.6 0.91431 -0.33804 0 0 0 0 0 0 0 0 0 0 6.49084 0 Q5TIE3 VW5B1_HUMAN von Willebrand factor A domain-containing protein 5B1 VWA5B1 Homo sapiens (Human) extracellular region [GO:0005576] EGEIEQGSNRR;LRGPGAR;RLHKDIPHHSVIMLNFCPDLQSVQPCLR 3 3.8 0.97852 -2.1491 0 0 0 0 0 0 0 7.19101 0 0 7.49161 0 Q5TKA1 LIN9_HUMAN Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) LIN9 BARA TGS Homo sapiens (Human) DNA biosynthetic process [GO:0071897]; DNA-templated transcription [GO:0006351]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677] DLNKVLHK 1 1.5 0.98036 -1.6134 0 0 8.18259 0 0 0 0 0 0 0 0 0 Q5TYW1 ZN658_HUMAN Zinc finger protein 658 ZNF658 Homo sapiens (Human) cellular response to zinc ion [GO:0071294]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosome biogenesis [GO:0042254] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" AALIVHQR;ITLFNHMR;SYECNDCGK;TSHLRAHQR 4 3.2 0.97306 -2.4998 0 0 0 0 10.7425 9.51469 0 7.88368 0 0 0 0 Q5TZA2 CROCC_HUMAN Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) cellular homeostasis [GO:0019725]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365] 9+2 motile cilium [GO:0097729]; actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; subapical part of cell [GO:0120219] actin binding [GO:0003779]; kinesin binding [GO:0019894]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] EAEELRTQLR;ELERSHRQLEQLEGK;ETLTGELAGLR;GLEEQVSTLK;LALLEEAR;LRSANELLSREK;QNLEKDQVNK;SLGEGAK;VAEQAQEALEQQLPTLR;VDSLQRQVADSEVK 10 5.7 0.97433 -3.0519 11.8739 0 12.5436 0 10.1602 10.8111 11.2719 9.92352 0 0 9.78842 0 Q5TZF3 ANR45_HUMAN Ankyrin repeat domain-containing protein 45 ANKRD45 Homo sapiens (Human) cell population proliferation [GO:0008283] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496] LTLKKYIAK 1 3.4 0.88232 -0.17999 0 0 0 4.86829 0 0 0 0 0 0 0 0 Q5U3C3 TM164_HUMAN Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase) TMEM164 Homo sapiens (Human) positive regulation of ferroptosis [GO:0160020] membrane [GO:0016020] LPAKKID 1 2.4 0.96692 -1.2799 0 0 0 0 0 0 0 9.49562 0 8.6537 0 0 Q5U4N7 GDAS1_HUMAN "Protein GDF5-AS1, mitochondrial (GDF5 antisense RNA 1) (Growth/differentiation factor 5 opposite strand transcript protein)" GDF5-AS1 GDF5OS Homo sapiens (Human) mitochondrion [GO:0005739] VASGARR 1 2.8 0.78073 0.032833 0 0 0 0 9.65926 0 0 0 0 0 0 0 Q5U4P2 ASPH1_HUMAN Aspartate beta-hydroxylase domain-containing protein 1 (EC 1.14.11.-) ASPHD1 Homo sapiens (Human) membrane [GO:0016020] dioxygenase activity [GO:0051213] EGRGSFSVERGPR 1 3.3 0.86937 -0.091336 0 0 0 0 0 0 0 0 0 0 4.23304 0 Q5U5Q3 MEX3C_HUMAN RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) MEX3C RKHD2 RNF194 BM-013 Homo sapiens (Human) chondrocyte hypertrophy [GO:0003415]; energy homeostasis [GO:0097009]; regulation of fat cell differentiation [GO:0045598] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] EDVAMAK 1 1.1 0.90945 -0.31064 0 0 0 0 8.17403 0 0 0 0 0 0 0 Q5U5R9 HECD2_HUMAN Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) HECTD2 Homo sapiens (Human) protein polyubiquitination [GO:0000209] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] EAAENRSSPAHLVFPNIKNVR;KEAAENRSSPAHLVFPNIK;LVGILMGLAVYNSITLDIR 3 5.3 0.9756 -1.4716 0 0 11.3894 11.9155 0 0 0 8.47626 0 0 0 0 Q5U5Z8 CBPC2_HUMAN Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2) AGBL2 CCP2 Homo sapiens (Human) protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] CKEGTGRVVMWR;DLNRHYK;FTQCLAELKELLRQEIHK;KGTVVYQLDSVPIEGSYFTSSR;LNETNLNRR;VHPGESNGSWVMK 6 9 0.72998 0.11311 0 12.6271 0 0 6.50637 0 5.77104 13.3195 13.5137 0 9.92285 0 Q5U623 MCAF2_HUMAN Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) ATF7IP2 MCAF2 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription coregulator activity [GO:0003712] IGKTECR 1 1 0.98047 -1.5491 0 0 0 0 0 0 0 8.42345 0 0 0 0 Q5U649 CL060_HUMAN Uncharacterized protein C12orf60 C12orf60 Homo sapiens (Human) DKERLIQAAK;EQSDVTTSERTR;SPPGSSK;TTMIDTLK;VAMAMCSVVQK 5 19.6 0.97476 -3.4606 0 0 0 0 0 0 13.8959 8.84865 0 0 0 10.3192 Q5U651 RAIN_HUMAN Ras-interacting protein 1 (Rain) RASIP1 Homo sapiens (Human) angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; positive regulation of integrin activation [GO:0033625]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] cell-cell junction [GO:0005911]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803] EQHVFGRGGNSSGR 1 1.5 0.98174 -1.5835 0 0 0 0 10.4098 0 13.2629 0 0 0 0 0 Q5UCC4 EMC10_HUMAN ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) EMC10 C19orf63 INM02 UNQ764/PRO1556 Homo sapiens (Human) angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] LLLLLLMAVAAPSRAR;RGSLLWNQQDGTLSLSQR 2 13 0.88821 -0.18353 0 0 5.45141 0 8.42009 0 4.3307 0 0 0 0 0 Q5UE93 PI3R6_HUMAN Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) PIK3R6 C17orf38 Homo sapiens (Human) angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of T cell differentiation [GO:0045582]; regulation of natural killer cell mediated cytotoxicity [GO:0042269] "cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]" MESSDVELDLQR;SPVLVRILLR;SPVLVRILLRELEK;VSVLSTDSGIER 4 5 0.93307 -0.51257 0 0 9.4522 0 0 0 0 7.25238 0 7.5627 4.73882 0 Q5UIP0 RIF1_HUMAN Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) RIF1 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic stem cell population maintenance [GO:0035019]; subtelomeric heterochromatin formation [GO:0031509]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]" "chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; spindle midzone [GO:0051233]" EEKPEETPK;GCDCCGEK;GLEEIPVFDISEK;LTSLFKLIVK;SGAPMIK;STDFVFIPPEGKDAK;TGISEEAAIEENKRNDDSEADTAK;TIGDLSTLTASEIK;VTESNLEK 9 4.4 0.9746 -3.4858 0 0 9.34769 11.4901 9.51193 0 0 10.0034 8.45043 0 5.88015 9.78616 Q5VIR6 VPS53_HUMAN Vacuolar protein sorting-associated protein 53 homolog VPS53 PP13624 Homo sapiens (Human) "endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] AEKSEQMVK;DKAEKSEQMVK;KAPASYTK;LDDNIRTVVRGQTNVGQDGR 4 4.7 0.84004 -0.043952 0 0 0 0 0 7.51578 0 0 0 0 0 0 Q5VIR6 VPS53_HUMAN Vacuolar protein sorting-associated protein 53 homolog VPS53 PP13624 Homo sapiens (Human) "endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] AEKSEQMVK;DKAEKSEQMVK;LDDNIRTVVRGQTNVGQDGR;YFTQFCVKFAK 4 6.2 0.97497 -3.223 0 0 6.77584 0 8.657 0 0 0 0 11.5653 0 0 Q5VIY5 ZN468_HUMAN Zinc finger protein 468 ZNF468 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGNQVEK;KHQIIHLEEKQCK;LHSGEKP;RIHSGEKPYKCEECCK;SINNASSVSTSQR;TLYRDVMLENYR;VCDKAFQR 7 14.6 0.97583 -3.4285 11.7801 0 5.87708 0 0 0 12.4637 12.6143 0 0 0 0 Q5VSG8 MANEL_HUMAN "Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC 3.2.1.-)" MANEAL Homo sapiens (Human) Golgi membrane [GO:0000139] alpha-mannosidase activity [GO:0004559] YKNSMGK 1 1.5 0.67183 0.16733 0 0 0 0 0 0 0 0 0 0 8.3431 0 Q5VSL9 STRP1_HUMAN Striatin-interacting protein 1 (Protein FAM40A) STRIP1 FAM40A KIAA1761 Homo sapiens (Human) cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; negative regulation of hippo signaling [GO:0035331]; regulation of cell morphogenesis [GO:0022604] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; nucleus [GO:0005634] protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] AISAVLLLLLKHFK;CFEEDFRIHVTDK;EVIVKAISAVLLLLLK;HKEVIVKAISAVLLLLLK;MNRKCFEEDFR;SILGLPPLPEDSIKVIR;SILGLPPLPEDSIKVIRNMR 7 7.8 0.97265 -2.6097 0 0 3.63529 0 4.55348 7.38543 5.02972 0 0 0 4.38619 5.59279 Q5VST9 OBSCN_HUMAN Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) OBSCN KIAA1556 KIAA1639 Homo sapiens (Human) protein localization to M-band [GO:0036309]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214] cytosol [GO:0005829]; M band [GO:0031430]; myofibril [GO:0030016]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018] "3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]" AGASVEWR;AGKTMAIAAQGACR;ALAAKIIPYHPKDK;ALPARFTQDLK;DGDRYSLK;DGRTLSPGPK;EEIGRGVFGFVK;EGVELHAGPK;FQTLSEPR;GFFGCETPDDKTQAK;GTAVFTCK;ILRLMPADAGVYR;IRQEGRTYTLIYR;KPPLQPPVDPVVK;LQDLEVREK;LRVFVRNR;LVVQEAGQADAGEYSCK;LYRKGVVTEAEVK;MEAVGCTRR;MLERFTPKK;NLRPQDSCR;SIQRADAGIVR;VKGYPAPRLYWFK;VKPVVFLKALDDLSAEER 24 3.3 0.97891 -14.544 0 7.10549 10.2762 10.4128 0 5.02813 13.2705 9.25004 10.4667 13.8729 14.4456 13.6312 Q5VSY0 GKAP1_HUMAN G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa) GKAP1 GKAP42 FKSG21 Homo sapiens (Human) positive regulation of insulin receptor signaling pathway [GO:0046628]; signal transduction [GO:0007165] Golgi apparatus [GO:0005794] identical protein binding [GO:0042802] EENWQEWRQR;IERLKLELER;LEYEEHK;NVITQWEAKYK 4 10.4 0.97487 -3.0804 0 0 0 0 0 0 5.14759 0 3.7182 0 0 10.3724 Q5VT06 CE350_HUMAN Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) microtubule anchoring [GO:0034453]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539] cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819] microtubule binding [GO:0008017] AEQEALESQRQLEETR;DIHEQKNTKEK;DSQSCRDKPQPMR;ERQLILKQQEEIEK;IESSIDEQVQTAADDSLR;INSSYFRR;ISLLTDSLLKVFVKDTVNQLQQIK;KILGPAPRMEPK;LDVLHRHLQRNSER;RSSSGSSR;SAGESKLDSHSDDDTK;SETAKNWK;SGGHIGR;TLSSASEKPK;VKNVPPSEPSATR 15 6.2 0.97697 -5.6303 12.1043 10.2386 7.80491 7.30907 11.4727 11.7062 0 7.80187 9.60101 10.8752 0 10.9082 Q5VT25 MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) CDC42BPA KIAA0451 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; protein phosphorylation [GO:0006468] actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALAIVCDFK;DLPMNPRPQESR;EGIHANEIKNLK;ELVQASERLKNQSK;GIGTAYEGHVR;KDIPCIFR;KSIFYEEELSK;LEQEKLELSR;LIYFKNK;RAETACFR;VESLRQELRR;VLLTEENKK 12 7 0.97574 -5.102 0 12.1157 11.7881 7.21062 0 0 9.5291 9.38729 11.8815 11.5443 11.9277 0 Q5VT25 MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) CDC42BPA KIAA0451 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; protein phosphorylation [GO:0006468] actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALAIVCDFK;DLPMNPRPQESR;EGIHANEIKNLK;GIGTAYEGHVR;KDIPCIFR;KSIFYEEELSK;LEQEKLELSR;LEVHTEALAAEASKDR;LIYFKNK;RAETACFR;VLLTEENKK 11 6.9 0.91687 -0.4292 0 0 0 0 0 0 8.70656 0 0 0 0 0 Q5VT52 RPRD2_HUMAN Regulation of nuclear pre-mRNA domain-containing protein 2 RPRD2 KIAA0460 HSPC099 Homo sapiens (Human) mRNA 3'-end processing [GO:0031124] nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550] RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] LEEFVNGLDK 1 0.7 0.89757 -0.23486 0 0 9.93528 0 0 0 0 0 0 0 0 0 Q5VT79 AXA81_HUMAN Annexin A8-like protein 1 ANXA8L1 ANXA8L2 Homo sapiens (Human) endosomal transport [GO:0016197]; endosome organization [GO:0007032] cytoplasm [GO:0005737]; sarcolemma [GO:0042383]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786] EGVIIEILASRTK;ELHDAMK;GLGTKEGVIIEILASRTK;NALLSLVGSDP 4 11 0.95556 -0.80853 6.70321 8.76934 0 0 0 0 0 0 8.04963 8.31954 7.37539 0 Q5VT97 SYDE2_HUMAN Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) SYDE2 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; regulation of Ras protein signal transduction [GO:0046578]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; synaptic membrane [GO:0097060] GTPase activator activity [GO:0005096] CIMEIEK;HIEVLHYLLQLWPVQRLTVKK;KNSMSSK;LQKWMYKGR;LVASYHEVNK;SGKGDRQEGPSFLRPPAVTVK 6 6.3 0.97523 -3.1774 0 12.7351 0 0 0 0 10.6289 0 0 0 0 10.3921 Q5VT98 PRA20_HUMAN PRAME family member 20 PRAMEF20 PRAMEF21 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] MLGMLFHNIR;TLDEYFTCLFLWVKQREGLVHLCCK;TPPRLLELAGRSLLR 3 10.5 0.88591 -0.19565 0 0 0 0 0 0 0 0 12.7188 6.64384 0 0 Q5VT99 LRC38_HUMAN Leucine-rich repeat-containing protein 38 (BK channel auxiliary gamma subunit LRRC38) LRRC38 Homo sapiens (Human) positive regulation of voltage-gated potassium channel activity [GO:1903818]; potassium ion transmembrane transport [GO:0071805] plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] CAPNKDAEDEDEDK;DAEDEDEDK;LLVAGNR 3 7.1 0.91696 -0.34361 0 0 0 0 3.53792 0 0 0 0 5.8912 10.8863 0 Q5VTB9 RN220_HUMAN E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) RNF220 C1orf164 Homo sapiens (Human) dorsal/ventral neural tube patterning [GO:0021904]; noradrenergic neuron development [GO:0003358]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of transcription regulatory region DNA binding [GO:2000677] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nuclear lamina [GO:0005652]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IFAVSGLISDR;WASDEMPSTSNGESSK 2 4.8 0.91575 -0.33279 0 0 0 0 0 0 0 0 0 5.51687 0 0 Q5VTE6 ANGE2_HUMAN Protein angel homolog 2 ANGEL2 KIAA0759L Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; mitochondrial mRNA 3'-end processing [GO:0090616]; negative regulation of mitotic cell cycle [GO:0045930] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] catalytic activity [GO:0003824]; mRNA 3'-UTR binding [GO:0003730] CEDSENK;GRYPMFPHHSR;NVDPKCEDSENK 3 4.2 0.97687 -2.2067 9.43108 0 2.48846 0 0 0 0 6.37271 0 5.80887 0 0 Q5VTH9 DNAI4_HUMAN Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78) DNAI4 WDR78 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; hematopoietic progenitor cell differentiation [GO:0002244] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; motile cilium [GO:0031514] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] DVQCDKIIMEDK;FTTILFAK;GTTGDGKR;ISKWVIRK 4 4.2 0.97325 -2.6506 0 0 0 9.55536 0 10.4707 10.4564 0 6.75769 9.23244 0 0 Q5VTJ3 KLD7A_HUMAN Kelch domain-containing protein 7A KLHDC7A Homo sapiens (Human) membrane [GO:0016020] FSAQEQR 1 0.9 0.93815 -0.5752 0 0 0 0 0 0 6.66633 0 0 0 0 0 Q5VTL7 FNDC7_HUMAN Fibronectin type III domain-containing protein 7 FNDC7 Homo sapiens (Human) extracellular region [GO:0005576] AGGRETCLPLIGFILICLK;IPGDDSTCNQR;STNDDATYTVTAQGEK 3 6.3 0.89266 -0.22478 0 0 0 0 0 6.08485 0 8.44439 0 4.90304 0 0 Q5VTM2 AGAP9_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP-9) (Centaurin-gamma-like family member 6)" AGAP9 CTGLF6 Homo sapiens (Human) GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] SFGTRLSR;SQLTSQSEAMALQSIQNMR 2 3.8 0.96482 -1.1633 0 7.6532 0 0 0 0 0 0 0 0 0 0 Q5VTQ0 TT39B_HUMAN Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) TTC39B C9orf52 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol metabolic process [GO:0090181] KYTVVESFSSLLSR 1 2.1 0.7315 0.12084 0 0 0 0 0 0 10.6748 0 0 0 0 0 Q5VTT2 CFA95_HUMAN Cilia- and flagella-associated protein 95 CFAP95 C9orf135 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] DREAFPKGYDIEGPEK;DSLDRSCQDWCDR;KCRSQFTDLNGSK;LYPLTSGPIVPI 4 23.6 0.97897 -1.96 0 10.9318 0 0 0 0 0 0 7.58879 0 0 0 Q5VTT5 MYOM3_HUMAN Myomesin-3 (Myomesin family member 3) MYOM3 Homo sapiens (Human) sarcomere organization [GO:0045214] M band [GO:0031430] protein homodimerization activity [GO:0042803] INFDREK;LEHRQEEEQKEER;NDQPVTFLDR;VGTSEWQTVNNKPIQGTRFTVPGLRTGK 4 4 0.98101 -1.7302 0 7.15826 0 0 0 0 10.9715 7.99447 0 0 0 10.8342 Q5VU43 MYOME_HUMAN Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGL Homo sapiens (Human) astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358] centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634] enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090] AEFACSKCAFMLDRIYR;CDCCSDDQAPQHGCNHK;DNSDKTLEANEMLLEKLR;LELALSMIK;QTDQGSMQIPSR;TQEQNIQHLNHSLSHK 6 7.9 0.92772 -0.45864 0 4.8127 0 0 0 0 0 13.5152 0 0 6.87147 0 Q5VU43 MYOME_HUMAN Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGL Homo sapiens (Human) astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358] centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634] enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090] ARTNLEEPCKK;DNSDKTLEANEMLLEKLR;ELKAQIEEAGFSSVSHIR;ILEPGYLGSSGK;IYFLEER;LLLSEATVFAQANELEKYR;LLVKKIVSLVR;LSLQENDSRLQHK;LVEQLSREK;QFEERQQETEHVYELLENK;QQEVLHFR;QTDQGSMQIPSR;SLTPSSSHALSDSHR;TQEQNIQHLNHSLSHK;YQDLQEK 15 8.3 0.97529 -4.2084 6.56015 6.97005 9.58161 8.22159 9.79481 8.86892 8.58064 12.813 8.76198 10.5335 0 0 Q5VU57 CBPC6_HUMAN Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6) AGBL4 CCP6 Homo sapiens (Human) anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; defense response to virus [GO:0051607]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; regulation of blastocyst development [GO:0120222]; retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] VVLRVIFNIVNFSK 1 2.8 0.83253 -0.028216 0 0 0 0 11.7356 0 0 0 0 0 0 0 Q5VU65 P210L_HUMAN Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like) NUP210L Homo sapiens (Human) membrane [GO:0016020]; nuclear pore [GO:0005643] FDNFSSLMLEWK;FPLEHYILELQDHR;GVYVCIIK;ITYDFPK;LHRLLLLFLVLR;LHRLLLLFLVLRGTLANK;VAILDDK;VALNGSHSEK;VPAGAQPCPLPQHNK;YFRNMELK 10 5.2 0.97616 -4.6303 0 3.96542 0 11.1089 8.13591 0 4.39712 0 0 4.62638 0 8.81644 Q5VUA4 ZN318_HUMAN Zinc finger protein 318 (Endocrine regulatory protein) ZNF318 HRIHFB2436 Homo sapiens (Human) meiotic cell cycle [GO:0051321]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; nucleoplasm [GO:0005654] nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] ASPSPPR;ESEIETNTELK;GAPETKLSGGPLANGENSNLSR;KMYYLRTELER;LGSPVDNLEDMDRDDLTDDSVFTR;RPRYDDTVK;RRSPSPR;VSPAHRSPTVLCQK 8 4.6 0.97531 -4.2302 0 0 8.81436 9.09114 0 10.5847 0 9.01672 0 0 0 9.08574 Q5VUB5 F1711_HUMAN Protein FAM171A1 (Astroprincin) (APCN) FAM171A1 APCN C10orf38 Homo sapiens (Human) regulation of cell shape [GO:0008360]; stress fiber assembly [GO:0043149] plasma membrane [GO:0005886] GSYNTVLSQPLFEK;TLREPGAGAQEVTLK 2 3.3 0.91545 -0.39542 0 0 0 0 0 0 11.6221 0 0 8.67426 10.0676 0 Q5VUE5 CA053_HUMAN Uncharacterized protein C1orf53 C1orf53 Homo sapiens (Human) mitochondrion [GO:0005739] QPSAAPPPAPLWVR 1 9.7 0.79789 0.014833 0 0 0 0 0 0 0 0 0 8.67951 0 0 Q5VUG0 SMBT2_HUMAN Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) SFMBT2 KIAA1617 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629] aggresome [GO:0016235]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] IAVVQPEKQLPPTVPVK;VLMPPDAIK;VLRELQLVEDPHWNFQEETLK;YCGYGEDRR 4 6.3 0.95561 -0.88153 0 0 0 8.71949 0 0 0 12.4249 8.93139 0 0 0 Q5VUJ6 LRCH2_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 2 LRCH2 KIAA1495 Homo sapiens (Human) DQIDEQPWPESHPIIWQSEERRR;GKVHIFKYLNIQACCR;LSMAKCR;LVSIPEEIGK 4 7.3 0.71537 0.13967 0 0 0 0 0 0 0 0 11.6348 0 0 10.6561 Q5VUJ9 DRC8_HUMAN Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2) EFCAB2 DRC8 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509] LGPGQVRLRPRVWR 1 5.2 0.55267 0.18321 0 0 0 0 9.78586 0 0 0 0 0 0 0 Q5VUR7 A20A3_HUMAN Putative ankyrin repeat domain-containing protein 20A3 (Ankyrin repeat domain-containing protein 20A3 pseudogene) ANKRD20A3P ANKRD20A3 Homo sapiens (Human) EKTEGVVSIK;LFGFGSR;MVEFLLKR;QLEPTVQSLEMK;YQQELNYLKAENTR 5 6.2 0.97355 -2.9784 0 0 0 11.6919 0 9.51023 0 6.34165 0 0 8.86508 0 Q5VUY0 ADCL3_HUMAN Arylacetamide deacetylase-like 3 (EC 3.1.1.-) AADACL3 Homo sapiens (Human) membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] FGTIPVKLYQPK;SLDAYGVDPAR 2 5.7 0.95641 -0.99411 0 0 0 0 0 0 11.3145 0 0 0 0 0 Q5VUY2 ADCL4_HUMAN Arylacetamide deacetylase-like 4 (EC 3.1.1.-) AADACL4 Homo sapiens (Human) membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] ALETYGVDPSRVVVCGESVGGAAVAAITQALVGRSDLPR;IVNAVVSYIK;KFMVTSLCNYLAIDLSWR;LEDQGVR;VTWYHLYDGFHGSIIFFDK;WLSPDNIPK 6 25.1 0.97313 -2.9481 12.2981 0 0 13.4991 0 6.23682 14.3373 14.3327 0 14.2721 0 0 Q5VV17 OTUD1_HUMAN OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) OTUD1 DUBA7 OTDC1 Homo sapiens (Human) protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] YRFHIIPDGNCLYRAVSK 1 3.7 0.50822 0.18773 0 0 0 0 0 0 0 0 0 0 10.1914 0 Q5VV43 K0319_HUMAN Dyslexia-associated protein KIAA0319 KIAA0319 Homo sapiens (Human) multicellular organismal response to stress [GO:0033555]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; positive regulation of SMAD protein signal transduction [GO:0060391]; response to auditory stimulus [GO:0010996] clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] DLTFLGKDWGLEEMSEYSDDYR;IRAHSDLSTVIVFYVQSRPPFK;VTVSSENAFGEGFVNVTVKPARR 3 6.2 0.95505 -0.97896 11.5119 0 0 0 0 0 0 0 5.78733 0 6.97808 0 Q5VV63 ATRN1_HUMAN Attractin-like protein 1 ATRNL1 KIAA0534 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] carbohydrate binding [GO:0030246]; Notch binding [GO:0005112] CYRYADCASCTANTNGCQWCDDKK;LTEPSGYLTDGPINYK;SIYVHGGYK;TCGQCLEQPGCGWCNDPSNTGR;TGSCFSGRCVNSTCLCDPGWVGDQCQHCQGR;TSCSNCTSNGMECMWCSSTK;YADCASCTANTNGCQWCDDKKCISANSNCSMSVK 7 9.8 0.95713 -0.9986 10.99 10.852 12.0058 0 0 0 0 0 0 7.33154 8.39038 0 Q5VV67 PPRC1_HUMAN Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) PPRC1 KIAA0595 Homo sapiens (Human) energy homeostasis [GO:0097009]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723] EDFDPAPVK;EGLSLNSEEK;EGSSLHKLLTLSRTPPER;GAVSSALGGSAPQLLVESESLDPPK;HKVSALVQSPQMK;ILGALESIPDSELLVSPR;MRHCWGPCR;SLSPPHK 8 7.1 0.9722 -2.8284 0 5.56194 0 9.43954 6.55411 6.34975 9.47814 10.3489 0 0 10.0721 10.057 Q5VVH5 IKBP1_HUMAN Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) IRAK1BP1 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; nucleus [GO:0005634] signaling adaptor activity [GO:0035591] VENAYHMEAEVCITFTEFGK;VFVELVPWADRSR 2 12.7 0.94099 -0.61 0 0 6.68678 0 0 0 0 0 0 4.75039 0 0 Q5VVJ2 MYSM1_HUMAN "Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)" MYSM1 KIAA1915 Homo sapiens (Human) chromatin remodeling [GO:0006338]; immune system process [GO:0002376]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; regulation of hemopoiesis [GO:1903706] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; transcription coactivator activity [GO:0003713] CGLDKETPNQK;GRPVKSLKVPRPTK;QEPFQVK 3 3.9 0.95514 -0.79553 8.81279 0 2.75566 0 0 0 9.12954 0 0 3.39808 0 0 Q5VVM6 CCD30_HUMAN Coiled-coil domain-containing protein 30 (Prefoldin subunit 6-like protein) CCDC30 PFDN6L Homo sapiens (Human) EALREEYLR;EKQLASGLDTAEK;ENKQLQENSLR;IIRSIHIRR;KLEHAHKVCLTDTCISEK;LLYQNVDELHRQVR;SPENLVCSQNSEAGYINVASLK;SQEKNEMFESEWSKER;VLKLSQEFAQLNHFTLGGK 9 16.7 0.97563 -5.131 0 6.15271 10.5538 11.4669 0 0 13.2923 8.08513 12.1101 10.8689 0 11.8732 Q5VVW2 GARL3_HUMAN GTPase-activating Rap/Ran-GAP domain-like protein 3 GARNL3 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] ATLETPTFAQK;ATLETPTFAQKR;NLYKIPLRNLVGR;SEGAPKAKSKPR;SILSAMNLDK;SLHQDLMPDLHK 6 5.8 0.97536 -3.5992 12.8598 11.0494 0 0 10.2546 0 0 12.8234 0 0 11.7861 13.6231 Q5VVY1 NTM1B_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 2 (EC 2.1.1.299) (Alpha N-terminal protein methyltransferase 1B) (Methyltransferase-like protein 11B) (X-Pro-Lys N-terminal protein methyltransferase 1B) (NTM1B) NTMT2 C1orf184 METTL11B NRMT2 Homo sapiens (Human) N-terminal protein amino acid methylation [GO:0006480] cytoplasm [GO:0005737]; nucleus [GO:0005634] N-terminal protein N-methyltransferase activity [GO:0071885] GAHFAFR 1 2.5 0.94059 -0.58708 13.3144 0 0 0 0 0 0 0 0 0 0 0 Q5VW00 DC122_HUMAN DDB1- and CUL4-associated factor 12-like protein 2 (WD repeat-containing protein 40C) DCAF12L2 WDR40C Homo sapiens (Human) Cul4-RING E3 ubiquitin ligase complex [GO:0080008] EGGTGVR;QLDLGTLNK;QVVCGTK 3 5 0.89636 -0.23775 0 0 0 0 0 0 11.3932 10.6366 0 0 0 0 Q5VW38 GP107_HUMAN Protein GPR107 (Lung seven transmembrane receptor 1) GPR107 KIAA1624 LUSTR1 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583] clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] clathrin heavy chain binding [GO:0032050] HILSDKDK;IIAFLLKLAVPFQWK;RNDVFKIHWLMAALPFTK;VKSPPEAGTQLPKIIFSR 4 9.8 0.96434 -1.2234 6.3346 0 0 9.73939 5.80846 0 0 0 3.00101 0 0 0 Q5VWI1 TCRGL_HUMAN Transcription elongation regulator 1-like protein TCERG1L Homo sapiens (Human) nucleus [GO:0005634] RNA polymerase binding [GO:0070063]; transcription coregulator activity [GO:0003712] VTHFRDMLLERGVSAFSTWEK 1 3.6 0.50128 0.18912 0 0 0 0 0 0 0 0 0 0 0 9.78602 Q5VWJ9 SNX30_HUMAN Sorting nexin-30 SNX30 Homo sapiens (Human) endocytic recycling [GO:0032456]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407] phosphatidylinositol binding [GO:0035091] DLFVIVDDPKK;FSEEFVETRRK;RRYQDFDWLR 3 7.3 0.93609 -0.5269 0 0 0 0 0 0 0 0 0 6.07232 0 7.80174 Q5VWK0 NBPF6_HUMAN NBPF family member NBPF6 (Neuroblastoma breakpoint family member 6) NBPF6 Homo sapiens (Human) cytoplasm [GO:0005737] ASLVLILKTIRR;QVSLALVDKIK;VCSAQDVAR 3 5 0.97645 -2.1759 0 0 0 0 0 0 0 0 0 0 8.94175 0 Q5VWK5 IL23R_HUMAN Interleukin-23 receptor (IL-23 receptor) (IL-23R) IL23R Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-23-mediated signaling pathway [GO:0038155]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] ENTGPLETR;ILLLIPK;RRILLLIPK 3 2.9 0.96479 -1.2258 0 7.16461 0 0 0 0 0 0 2.35643 0 0 0 Q5VWN6 TASO2_HUMAN Protein TASOR 2 TASOR2 C10orf18 FAM208B KIAA2006 Homo sapiens (Human) "negative regulation of gene expression, epigenetic [GO:0045814]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] ADRSPSLSVAPQDRMK;IHPNTLVKRHFQELYK;ILEKLNGNGR;LTECIKNK;MAPPAHK;YNSTVKESR;YVSINSTLESCELR 7 3.3 0.9763 -4.71 0 0 0 8.69599 0 0 10.8831 12.062 8.62007 0 0 8.35346 Q5VWP2 TET5C_HUMAN Terminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C) TENT5C FAM46C Homo sapiens (Human) in utero embryonic development [GO:0001701]; mRNA stabilization [GO:0048255]; negative regulation of cell differentiation [GO:0045596] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] KLETYLQNHFAEEER;TLERYMCSR;VVNESTVCLMGHERR 3 10 0.95288 -0.7347 2.44369 0 0 0 0 0 0 0 0 0 8.92023 0 Q5VWP3 MLIP_HUMAN Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein) MLIP C6orf142 Cip Homo sapiens (Human) negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nucleus [GO:0005634]; PML body [GO:0016605]; sarcolemma [GO:0042383] lamin binding [GO:0005521]; transcription corepressor activity [GO:0003714] SLSSCSLR 1 0.8 0.93657 -0.5485 0 0 0 0 0 0 10.1939 0 0 0 0 0 Q5VWP3 MLIP_HUMAN Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein) MLIP C6orf142 Cip Homo sapiens (Human) negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nucleus [GO:0005634]; PML body [GO:0016605]; sarcolemma [GO:0042383] lamin binding [GO:0005521]; transcription corepressor activity [GO:0003714] TQGTDLKTSSHPEMLHGMAPQQKHGQQYK 1 6.3 0.71175 0.15682 0 0 0 9.31175 0 0 0 0 0 0 0 0 Q5VWQ0 RSBN1_HUMAN Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) RSBN1 Homo sapiens (Human) nucleus [GO:0005634] histone H4K20 demethylase activity [GO:0035575]; metal ion binding [GO:0046872] EVLFEDR 1 0.9 0.94041 -0.58436 0 0 8.77159 0 0 0 0 0 0 0 0 0 Q5VWQ0 RSBN1_HUMAN Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) RSBN1 Homo sapiens (Human) nucleus [GO:0005634] histone H4K20 demethylase activity [GO:0035575]; metal ion binding [GO:0046872] KDIETTTISNFHTQ 1 3.1 0.75894 0.070691 0 0 0 0 0 0 13.6454 0 0 0 0 0 Q5VWQ8 DAB2P_HUMAN Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) DAB2IP AF9Q34 AIP1 KIAA1743 Homo sapiens (Human) angiogenesis [GO:0001525]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite development [GO:1900006]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cell cycle [GO:0051726]; regulation of GTPase activity [GO:0043087]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein-containing complex assembly [GO:0043254]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] AIP1-IRE1 complex [GO:1990597]; axon [GO:0030424]; cerebellar mossy fiber [GO:0044300]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; parallel fiber [GO:1990032]; plasma membrane [GO:0005886] 14-3-3 protein binding [GO:0071889]; cadherin binding [GO:0045296]; death receptor binding [GO:0005123]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; vascular endothelial growth factor receptor 2 binding [GO:0043184] CFSCRSAAER;LEEGEERLRR;LMSVEEELK;SLPGSLSEK;WYPVVTPNPK 5 4 0.97413 -2.4297 0 0 0 11.1901 0 0 0 0 0 0 5.17117 10.2882 Q5VWT5 FYB2_HUMAN "FYN-binding protein 2 (Activation-dependent, raft-recruited ADAP-like phosphoprotein)" FYB2 ARAP C1orf168 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852] immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] EGEGVRNFKELR;QPAAVPK;QPCELKPKNTEK 3 4.3 0.98 -1.8308 0 0 0 0 0 0 0 0 0 0 9.77227 0 Q5VWX1 KHDR2_HUMAN "KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1)" KHDRBS2 SLM1 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] FQGSDGK;KFLVPDYNDEIRQEQLR;LQEETGAK;QYPKFNFVGKLLGPR 4 13.5 0.97631 -2.1983 0 0 8.04849 0 0 0 0 0 0 0 0 0 Q5VX52 SPAT1_HUMAN Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2) SPATA1 Homo sapiens (Human) acrosomal vesicle [GO:0001669] DPSLLENTLK;EKIIKQMK;KVTASMEEVLTKLR 3 7 0.97879 -2.0933 0 0 0 0 12.6305 0 9.82029 0 0 0 0 0 Q5VX71 SUSD4_HUMAN Sushi domain-containing protein 4 SUSD4 UNQ196/PRO222 Homo sapiens (Human) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]" extracellular region [GO:0005576]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211] IVAFTATSVLLVLLLVILAR 1 4.1 0.78319 0.025586 0 0 0 0 0 0 0 0 4.79712 0 0 0 Q5VXH4 PRAM6_HUMAN PRAME family member 6 PRAMEF6 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AELMKRVR;LPLRPLIK;RLPLRPLIK;SFYDLEADQCCC;TLDEYLTCLLLWVKQR;TPPRLLELAGRSLLR;WVLPILTQFTPYLGHMRNLQK 7 17 0.97225 -2.7312 0 7.31904 0 4.54844 4.27925 0 11.9842 12.1746 0 0 6.88228 5.31676 Q5VXH5 PRAM7_HUMAN PRAME family member 7 PRAMEF7 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SPHLESLKSVLEGVDVLLTQEVRPR 1 5.3 0.83829 -0.039211 0 11.0917 0 0 0 0 0 0 0 0 0 0 Q5VXI9 LIPN_HUMAN Lipase member N (EC 3.1.1.13) (EC 3.1.1.3) (Lipase-like abhydrolase domain-containing protein 4) LIPN LIPL4 Homo sapiens (Human) cornification [GO:0070268]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576] lipoprotein lipase activity [GO:0004465] AVFGTKGFFLEDK 1 3.3 0.92371 -0.44887 0 7.74255 0 0 0 0 0 0 7.4363 0 0 0 Q5VXJ0 LIPK_HUMAN Lipase member K (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 2) LIPK LIPL2 Homo sapiens (Human) cornification [GO:0070268]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231] lipoprotein lipase activity [GO:0004465] MFHPHTLFDQFIATK 1 3.8 0.78291 0.025703 0 0 0 0 0 8.43917 0 0 0 0 0 0 Q5VXU3 CHIC1_HUMAN Cysteine-rich hydrophobic domain-containing protein 1 (Brain X-linked protein) CHIC1 BRX Homo sapiens (Human) cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] ALPVNVK 1 3.1 0.82302 -0.017932 0 0 0 0 0 0 0 0 0 12.1518 0 0 Q5VXU9 SHOC1_HUMAN Protein shortage in chiasmata 1 ortholog (EC 3.6.-.-) (Protein ZIP2 homolog) (MZIP2) SHOC1 C9orf84 ZIP2 Homo sapiens (Human) reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794] ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697] ILLRLRLAILK;INLLTAEESANEYYMMWQLERCR;IQEPHSQYSVTDLKKIFSVK;SETLGDELEILR 4 4.7 0.9784 -1.9342 0 0 6.19747 0 0 9.71409 0 0 0 0 0 9.26683 Q5VY43 PEAR1_HUMAN Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) PEAR1 MEGF12 Homo sapiens (Human) phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; positive regulation of platelet activation [GO:0010572]; recognition of apoptotic cell [GO:0043654] lamellipodium [GO:0030027]; membrane [GO:0016020]; phagocytic cup [GO:0001891] signaling receptor activity [GO:0038023] CDCDHSDGCDPVHGR;EHHHLAVAYSSGR;FGQDCAETCDCAPDAR 3 4.2 0.40426 0.20705 0 0 0 0 0 0 6.73227 4.06324 0 5.77629 0 0 Q5VYJ5 MALR1_HUMAN MAM and LDL-receptor class A domain-containing protein 1 MALRD1 C10orf112 DIET1 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794] CDFEFDLCSWKQEK;CDFKYDCPDK;DEDFDWNLK;QDCSDESDEDPATCSK;SLFPQQPMRAAR;VLYNQGKQWLEATIQLGR 6 3.7 0.97868 -2.1067 0 0 11.0858 10.1918 0 5.60615 0 4.89913 0 0 12.1572 0 Q5VYK3 ECM29_HUMAN Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) ECPAS ECM29 KIAA0368 Homo sapiens (Human) ERAD pathway [GO:0036503]; proteasome assembly [GO:0043248] centrosome [GO:0005813]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502] molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628] ALSINTLVKISK;FMNLANHHAMWNSRK;LLLQGLMDSVEAK;LMSALLSGLTDR;LPEIWETLFR;TLSLQFVHHICITCPEIK;VKLKIVPHLLR;VYLGDIPLK 8 5.4 0.97816 -1.9432 0 7.74705 3.9528 9.79211 8.73457 0 0 8.09461 7.90749 3.17623 0 0 Q5VYM1 S31G1_HUMAN Spermatogenesis-associated protein 31G1 SPATA31G1 C9orf131 Homo sapiens (Human) ASLTRGLQK;GLQKVLAK;NHPAQAR;WSVCSSVFFNK 4 2.9 0.97474 -3.8568 0 0 0 10.5839 0 0 11.3706 10.658 0 0 0 13.9725 Q5VYS8 TUT7_HUMAN Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) TUT7 HS2 KIAA1711 ZCCHC6 Homo sapiens (Human) miRNA metabolic process [GO:0010586]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; uridylyltransferase activity [GO:0070569]; zinc ion binding [GO:0008270] ELKDWPK;LSLFGSSKNGFGFK;LVPLVIAFRYWAK;NPIYSQPAWMNDSHKDQSK;VQPLTLK;VQPLTLKETAESFGSPPK 6 4.7 0.98027 -1.8692 10.9293 0 11.9244 5.95826 0 0 9.25321 0 0 0 9.61917 0 Q5VYV0 FOXB2_HUMAN Forkhead box protein B2 FOXB2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HNLSFNDCFIKIPRRPDQPGK 1 4.9 0.86429 -0.083824 0 0 0 0 0 0 0 0 0 0 0 9.09537 Q5VYV7 SLX4I_HUMAN Protein SLX4IP (SLX4-interacting protein) SLX4IP C20orf94 Homo sapiens (Human) EEVCLLLK;SPVCSCESASPCPK 2 5.4 0.93997 -0.5803 0 0 0 4.92101 0 0 0 0 0 0 0 0 Q5VYY2 LIPM_HUMAN Lipase member M (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 3) LIPM LIPL3 Homo sapiens (Human) cornification [GO:0070268]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576] lipoprotein lipase activity [GO:0004465] LETLSRQWIVSHR;NLEKCNQPTPVR 2 5.9 0.98032 -1.8645 0 0 0 0 0 0 0 0 0 0 0 12.6799 Q5VZ46 K1614_HUMAN Uncharacterized protein KIAA1614 KIAA1614 Homo sapiens (Human) centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cellular localization [GO:0060341] apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; nucleus [GO:0005634] LLPAEPR;LVGSLDRR;TCELPPSQTQPSRPQVR 3 2.7 0.73158 0.11499 0 0 9.60088 9.97542 0 0 6.46788 0 0 15.1297 10.1519 0 Q5VZ52 MORN5_HUMAN MORN repeat-containing protein 5 MORN5 C9orf113 C9orf18 Homo sapiens (Human) sperm flagellum [GO:0036126] YIGEYVDGR 1 5.6 0.93558 -0.51763 0 0 0 0 8.92086 0 0 0 0 0 0 0 Q5VZ66 JKIP3_HUMAN Janus kinase and microtubule-interacting protein 3 (Neuroendocrine long coiled-coil protein 2) JAKMIP3 C10orf14 C10orf39 JAMIP3 NECC2 Homo sapiens (Human) Golgi apparatus [GO:0005794] kinase binding [GO:0019900]; microtubule binding [GO:0008017] AVFVLER;LRHEVQDARDQNELLEFR;MELLQLAQQR;RPSSLNDLDQSQDEREVDFLK;VAVEQWK 5 7.5 0.97601 -2.3445 11.3938 0 0 10.2771 0 0 0 0 0 7.92659 0 9.92383 Q5VZ72 IZUM3_HUMAN Izumo sperm-egg fusion protein 3 IZUMO3 C9orf134 Homo sapiens (Human) acrosome assembly [GO:0001675] inner acrosomal membrane [GO:0002079]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] LEELMGK;SLKEYVEK;TWLKNEFYK 3 10 0.97414 -2.434 11.7402 0 0 0 0 0 9.61989 9.86705 0 0 0 11.3445 Q5VZ89 DEN4C_HUMAN DENN domain-containing protein 4C DENND4C C9orf55 C9orf55B Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; insulin-responsive compartment [GO:0032593]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; retromer complex [GO:0030904] guanyl-nucleotide exchange factor activity [GO:0005085] ACGALVYDEEIMAGWTADDSNLNTACPFCK;ATAADSLFDRQGFLK;GLAQFRQPLK;LAKRCYTNPPQWAK;QKHFPER;RQKHFPER;TVQRSQVSSISGGQSDQGYGSKDELIK 7 5.4 0.97477 -3.7133 0 9.37621 0 10.5815 0 0 0 0 11.1599 0 6.90617 0 Q5VZB9 DMRTA_HUMAN Doublesex- and mab-3-related transcription factor A1 DMRTA1 DMO Homo sapiens (Human) male mating behavior [GO:0060179]; ovarian follicle development [GO:0001541]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ASGGGGR;DSSYLSSK;RQQAQEESEARGLQR;VGISPLR 4 7.3 0.91587 -0.3953 9.71392 0 9.91165 10.3104 8.85462 0 0 0 9.85069 7.34749 12.7728 9.9484 Q5VZE5 NAA35_HUMAN "N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)" NAA35 EGAP MAK10 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; smooth muscle cell proliferation [GO:0048659] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EEMVNYFARLIDRIK;FTRVLLTVLIAFTKK;GDHPIMMGFEPLVNQR;TMVAFDMDGKVRKPK;VPPEFDFSAHK;VPPEFDFSAHKYFPVVK 6 10.8 0.92894 -0.48337 7.0332 7.25908 4.24458 5.13278 2.50134 9.3254 0 6.8627 9.56322 8.95163 0 0 Q5VZK9 CARL1_HUMAN "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)" CARMIL1 CARMIL LRRC16 LRRC16A Homo sapiens (Human) actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] ELIESIKDVIGR;LSTDVCEQILR;SNDSGEEAEK;TEDALQKIENYLLRNHETR;TPDSFEESQGEEIGK;VALLPPVLK;VALLPPVLKK;VALLPPVLKKVPSDK;VERSDSKSSPQAGR;VPSDKERDGQSSPQPSPR 10 8 0.97665 -2.1746 8.76325 0 8.58252 9.79714 9.71612 2.98293 0 0 0 9.88432 9.70229 9.95139 Q5VZK9 CARL1_HUMAN "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)" CARMIL1 CARMIL LRRC16 LRRC16A Homo sapiens (Human) actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] LSTDVCEQILR;YACVCDWLGFSYR 2 13.6 0.80616 0.011489 0 0 0 8.21859 0 0 0 0 0 0 0 0 Q5VZL5 ZMYM4_HUMAN Zinc finger MYM-type protein 4 (Zinc finger protein 262) ZMYM4 KIAA0425 ZNF262 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AEREVESGPR;IDNIFTEPYSR;IDNIFTEPYSRFMIELTKLLK;INNVMAMCEYCK;LKCQHCNRLFATKPELLDYK;LLKNKALLCKPITQTK;NCSDEYK;TSAIPQYHLAMSDGSIR;VTQHESDNENEIQIQNKLKK;YMYGVNAWK 10 8.5 0.9741 -3.8052 4.19125 4.29946 0 5.65661 8.79194 0 6.87922 0 10.0641 0 6.40834 11.6258 Q5VZP5 STYL2_HUMAN Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) STYXL2 DUSP27 Homo sapiens (Human) negative regulation of MAPK cascade [GO:0043409] cytoplasm [GO:0005737]; sarcomere [GO:0030017] MAP kinase phosphatase activity [GO:0033549]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] ASEFLDEALLTYRGK;EGREMHK;LASDNKRSSLFK;SQYRRSTDR;TLSESSAWESVSSHDIWVLKQQLELNRPDHGRR 5 6.6 0.97237 -2.7628 0 12.2085 0 8.39964 0 0 0 6.18937 11.939 0 0 11.9601 Q5VZQ5 TEX36_HUMAN Testis-expressed protein 36 TEX36 C10orf122 Homo sapiens (Human) EPQSPHLPRQAEGK;FNPPSDK 2 11.3 0.95135 -0.70365 0 0 10.3692 0 0 0 9.55217 0 0 0 0 0 Q5VZV1 MT21C_HUMAN Protein-lysine methyltransferase METTL21C (EC 2.1.1.-) (Methyltransferase-like protein 21C) METTL21C C13orf39 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; hormone-mediated apoptotic signaling pathway [GO:0008628]; peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; skeletal muscle tissue development [GO:0007519] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279] ELVWGEDLDK 1 3.8 0.92362 -0.44899 0 0 0 9.15613 0 0 0 0 0 0 0 0 Q5W041 ARMC3_HUMAN Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1) ARMC3 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; ribophagy [GO:0034517]; spermatid development [GO:0007286] extracellular exosome [GO:0070062] IPKEKLPDFSWELHISELK;SDVGYGR;SISSSSSLRRSSK;TLGVIANDK 4 5.5 0.98102 -1.7536 0 0 0 10.1585 0 11.6396 10.0749 10.8171 0 0 0 0 Q5W0A0 ERI6B_HUMAN Glutamate-rich protein 6B (Protein FAM194B) ERICH6B FAM194B Homo sapiens (Human) EPKASYSSQTMLLR;KFTYIILEDSLEGRIR;LILYPNK 3 5.3 0.93793 -0.57158 0 0 0 0 0 8.24688 10.5332 2.76252 0 0 0 0 Q5W0B1 OBI1_HUMAN ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) OBI1 C13orf7 RNF219 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] ADLNCSKNK;IQSSLSSASPSK;LVFDDFCDSSNVSNKDSSEDDISR 3 6.2 0.94747 -0.663 0 13.005 4.98336 0 10.1721 0 11.1399 11.8396 11.7301 0 8.24555 9.27242 Q5W0B7 TM236_HUMAN Transmembrane protein 236 TMEM236 FAM23A FAM23B Homo sapiens (Human) membrane [GO:0016020] LGLIIALGTITPVLGLCK 1 5.1 0.67795 0.16566 0 0 0 3.89375 0 0 0 5.40095 0 0 0 0 Q5W0N0 CI057_HUMAN Uncharacterized protein C9orf57 C9orf57 Homo sapiens (Human) membrane [GO:0016020] EEVHIQGGIQWYSVK;IVFAGVILFRLLGVILFR;LLGVILFRLLGVILFGR 3 26.1 0.8117 -0.014868 0 3.45799 0 5.1285 4.19912 8.64713 0 0 0 4.5435 0 0 Q5W0V3 FHI2A_HUMAN FHF complex subunit HOOK interacting protein 2A (FHIP2A) FHIP2A FAM160B1 KIAA1600 Homo sapiens (Human) ADCPPGMK;IRQPLLPHINVHRPVQKLIR;VLFDRMGR 3 4.7 0.96669 -1.2645 0 11.7236 0 0 0 0 0 0 6.68187 5.69508 6.93546 0 Q5W0Z9 ZDH20_HUMAN Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) ZDHHC20 Homo sapiens (Human) peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; synaptic vesicle maturation [GO:0016188] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270] TIRYCEK 1 1.9 0.90162 -0.26179 10.5021 0 0 0 0 0 0 0 0 0 0 0 Q5W186 CST9_HUMAN Cystatin-9 (Cystatin-like molecule) CST9 CLM CTES7A Homo sapiens (Human) antimicrobial humoral response [GO:0019730] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869] LLRVLSSWREDSMDR;MVFSMNLQLRQTVCRK 2 19.5 0.88135 -0.1515 0 0 0 6.84912 0 0 0 8.16027 9.87251 0 8.22212 0 Q5W188 CST9P_HUMAN Putative cystatin-9-like protein CST9LP1 (Cystatin-9-like pseudogene 1) CST9LP1 Homo sapiens (Human) antimicrobial humoral response [GO:0019730] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869] FQEEEEWNDQK 1 7.5 0.81017 0.0097957 0 0 0 0 0 0 0 0 4.73482 0 0 0 Q5W5X9 TTC23_HUMAN Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) TTC23 HCC8 Homo sapiens (Human) positive regulation of smoothened signaling pathway [GO:0045880] cilium [GO:0005929] EALSHYQAALEYVEISKGETSR;ELLQCGR 2 6.5 0.96312 -1.0812 0 0 0 0 0 0 0 0 0 4.07168 0 0 Q5XG87 PAPD7_HUMAN Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1) TENT4A PAPD7 POLS TRF4 Homo sapiens (Human) double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic stimulus [GO:0009410]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; sister chromatid cohesion [GO:0007062] Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499] ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; SMC family protein binding [GO:0043221] GHHQYNR;KYSLLPYLILVLKQFLLQR 2 3.3 0.91702 -0.41315 0 10.8162 0 0 0 0 5.46656 0 0 0 0 0 Q5XG99 LYSM4_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 4 LYSMD4 Homo sapiens (Human) membrane [GO:0016020] AGAGTGAQAGQLMGFFK;EQDLYALK;NGSGDSGDSSEEESHR 3 13.9 0.87375 -0.11688 0 0 0 0 0 10.3229 0 0 12.6036 3.45233 0 0 Q5XKE5 K2C79_HUMAN "Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38)" KRT79 K6L KB38 KRT6L Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] enzyme binding [GO:0019899]; structural constituent of skin epidermis [GO:0030280] AEAEAWYQTK;FASFIDK;FASFIDKVR;FLEQQNK;FLEQQNKVLETK;LQSERGR;NLDLDSIIAEVK;YEELQVTAGK 8 11.2 0.058923 0.44203 0 0 11.4721 0 0 0 0 0 0 10.5359 10.2738 0 Q5XKL5 BTBD8_HUMAN BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) BTBD8 KIAA1107 Homo sapiens (Human) synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; axon [GO:0030424]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EMGFTCKIQALRDK;EPNSDIPKNSSTK;KNKQSVSATEK;LDKSLKHELESK;QVSDSGDIKIK;SAIVHSR;SATAAAAATGQK;SLKHELESKQICLDK;VLTGNLNVQAKAKPLKK;WIVKHFAR 10 6.8 0.97568 -5.0787 11.6074 12.1162 0 7.29526 5.09546 0 8.68961 8.13247 0 6.41197 0 0 Q5XKP0 MIC13_HUMAN MICOS complex subunit MIC13 (Protein P117) MICOS13 C19orf70 MIC13 QIL1 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401] SQAALQK 1 5.9 0.9382 -0.57699 12.8996 0 13.1027 0 0 0 0 0 0 0 11.0944 0 Q5XKR4 OTP_HUMAN Homeobox protein orthopedia OTP Homo sapiens (Human) dopaminergic neuron differentiation [GO:0071542]; forebrain neuron differentiation [GO:0021879]; hypothalamus cell differentiation [GO:0021979]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron differentiation [GO:0030182]; positive regulation of neuroblast proliferation [GO:0002052] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SFAKTHYPDIFMR 1 4 0.88871 -0.18379 0 0 0 0 8.66342 0 0 0 0 0 0 0 Q5XKR9 VCF2_HUMAN Protein VCF2 (VCP nuclear cofactor family member 2) VCF2 CXorf44 FAM104B Homo sapiens (Human) RNPIFQDSQDTEFSWSDNER 1 17.9 0.30465 0.24938 6.42507 0 0 0 0 0 0 0 0 0 0 0 Q5XKR9 VCF2_HUMAN Protein VCF2 (VCP nuclear cofactor family member 2) VCF2 CXorf44 FAM104B Homo sapiens (Human) NKRNPIFQDSQDTEVAIFME 1 43.5 0.85176 -0.079704 0 0 0 6.47892 0 0 0 0 0 0 0 0 Q5XPI4 RN123_HUMAN E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; proteolysis involved in protein catabolic process [GO:0051603]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DDNGGEASRYIFLTKFR;FLLSNVLFDVLR;FLSTAAVSLMTPR;LAAILAK;LAQLLNQVLNR;RLAQLLNQVLNRVTAER 6 5 0.95554 -0.98011 12.419 9.97054 12.6638 0 0 0 0 11.3313 0 10.3307 10.6766 0 Q5XUX1 FBXW9_HUMAN F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) FBXW9 FBW9 Homo sapiens (Human) cytosol [GO:0005829] AGPALLK;MELPLGRCDDSR 2 4.1 0.90993 -0.28229 0 0 0 0 4.38045 0 10.3894 4.88284 0 0 0 0 Q5XX13 FBW10_HUMAN F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor) FBXW10 Homo sapiens (Human) cytosol [GO:0005829] APENEHLLGAASNPEEPWR;CETCVLAWK;EWFCRINDISQRR;INDISQR;INDISQRRFLVGILK;KCETCVLAWK;MVDDGKSMRVK;VISACADGKIRIYNFLNGNCMK;VLNFKGKSIQR 9 8.8 0.97669 -2.2451 0 11.6851 0 8.18864 9.87484 8.11395 11.4682 0 10.9258 0 8.23692 11.4224 Q5XXA6 ANO1_HUMAN Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) ANO1 DOG1 ORAOV2 TAOS2 TMEM16A Homo sapiens (Human) cellular response to heat [GO:0034605]; cellular response to peptide [GO:1901653]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; glial cell projection elongation [GO:0106091]; iodide transport [GO:0015705]; monoatomic ion transmembrane transport [GO:0034220]; mucus secretion [GO:0070254]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein localization to membrane [GO:0072657] apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793] calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellularly calcium-gated chloride channel activity [GO:0005229]; iodide transmembrane transporter activity [GO:0015111]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; voltage-gated chloride channel activity [GO:0005247] EEQDKQQLLETWMEK;QQLLETWMEK;YSTLPAEDR 3 2.4 0.93355 -0.50028 0 12.0381 11.871 9.51759 11.4176 8.88243 10.1716 6.98846 10.1563 0 12.3571 0 Q60I27 AL2CL_HUMAN ALS2 C-terminal-like protein ALS2CL Homo sapiens (Human) endosomal transport [GO:0016197] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DLTLTSNQR;SEYWRGQRK;TLMLTFQATYAGVGANK 3 3.7 0.98038 -1.6818 0 0 0 0 0 0 10.7221 0 0 8.85446 0 0 Q60I27 AL2CL_HUMAN ALS2 C-terminal-like protein ALS2CL Homo sapiens (Human) endosomal transport [GO:0016197] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DLTLTSNQR;WGSQGPEK 2 8.3 0.93627 -0.51843 0 0 0 0 0 0 0 0 0 10.1706 0 0 Q63HK3 ZKSC2_HUMAN Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) ZKSCAN2 ZNF694 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ENPYKCGVCGK;FYEALQACHRK;LYGAVAEQLR;SVHQIPAQRDLYRDFR 4 5 0.97514 -3.2734 0 0 0 0 0 0 0 11.2722 9.10494 0 0 0 Q63HK5 TSH3_HUMAN Teashirt homolog 3 (Zinc finger protein 537) TSHZ3 KIAA1474 TSH3 ZNF537 Homo sapiens (Human) "long-term synaptic potentiation [GO:0060291]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DDNHETDNNNPKR;SLLEMEGKEDAQK 2 2.4 0.95266 -0.7507 0 11.6845 12.6694 0 0 0 0 0 0 12.5182 0 11.2828 Q63HM2 PCX4_HUMAN Pecanex-like protein 4 (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2) (Pecanex homolog protein 4) PCNX4 C14orf135 FBP2 PCNXL4 Homo sapiens (Human) membrane [GO:0016020] LLLVGIIRDRLIQFISK;LNPEAVR 2 2 0.37152 0.22441 12.7068 12.6836 12.7654 0 0 0 0 0 0 8.5091 0 0 Q63HN8 RN213_HUMAN E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] AFITEDK;CGIPVIIMGETGCGKTR;DLVKQFQNVQQVEYSSIR;EACNQDALQEAGTFR;EALGGINELK;ETVQEFDLEKIQR;EVFTKNMLTSSGASFTYVK;GMEFVQGLSKPGRPHQWVFPK;KFGIVLSAVITKSWPR;LMLMSGK;LNDTVTVR;LQNFSRILTIYPQVLHSLMEAR;LRDAAQRHCEHTK;NLAFSPATMAHAFLPTMPEDLLAQARR;QTLSAAAVFNDR;TPVIRSVILKLLLK;TRVPQFSFLDIFPKVTCRPPK;VMNHITDGPRK;YSFHDVK;YSFHDVKDYIQEYLTLLK 20 5.6 0.9781 -6.2269 11.827 14.346 13.6294 4.92889 0 9.77187 11.4184 8.70829 11.4626 9.09104 11.2157 10.1688 Q63HQ2 EGFLA_HUMAN "Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" EGFLAM AGRINL AGRNL PIKA Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] basement membrane [GO:0005604]; cell projection [GO:0042995]; interstitial matrix [GO:0005614]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone [GO:0048786]; synaptic cleft [GO:0043083] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539] EGYDCDCPLGFEGLHCQK;GVLLRLLLLASSLGPGAVSLR 2 3.8 0.71633 0.14275 7.12309 0 0 7.00888 0 0 0 0 0 0 0 0 Q63HR2 TENS2_HUMAN Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) TNS2 KIAA1075 TENC1 Homo sapiens (Human) cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-tyrosine dephosphorylation [GO:0035335]; response to muscle activity [GO:0014850] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" YISYFSGLLSGSIR 1 1 0.78397 0.020168 0 0 0 0 0 0 0 0 0 6.24161 0 0 Q63ZE4 S22AA_HUMAN Solute carrier family 22 member 10 (Organic anion transporter 5) SLC22A10 OAT5 Homo sapiens (Human) organic anion transport [GO:0015711] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ISIPLDSNLRPEKCRR;NPSMRKR 2 4.3 0.9554 -0.86579 8.85938 8.44489 0 0 15.1276 0 0 17.6441 0 0 0 0 Q63ZY3 KANK2_HUMAN KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) KANK2 ANKRD25 KIAA1518 MXRA3 SIP Homo sapiens (Human) apoptotic process [GO:0006915]; kidney epithelium development [GO:0072073]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; podocyte cell migration [GO:0090521]; regulation of Rho protein signal transduction [GO:0035023] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] AQVLHVPAPFPGTPGPASPPAFPAK;ESQHIPTAEGASGSNTEEEIR;LGNINAK;LIPVLQVKLSVLQEEKR;QLEEQVK;VPTQEPTHR 6 10.1 0.95495 -0.87754 0 0 0 0 0 0 5.56304 6.57719 0 10.5605 8.50391 0 Q641Q3 METRL_HUMAN Meteorin-like protein (Subfatin) METRNL Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; negative regulation of inflammatory response [GO:0050728]; positive regulation of brown fat cell differentiation [GO:0090336]; response to cold [GO:0009409]; response to muscle activity [GO:0014850] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] hormone activity [GO:0005179] DFQRMYR 1 2.3 0.98206 -1.587 0 0 0 0 0 0 0 11.2737 0 0 0 0 Q643R3 LPCT4_HUMAN Lysophospholipid acyltransferase LPCAT4 (1-acylglycerol-3-phosphate O-acyltransferase 7) (1-AGP acyltransferase 7) (1-AGPAT 7) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (1-alkenylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.121) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 3) (Lysophosphatidylcholine acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase 2) (EC 2.3.1.n7) (Plasmalogen synthase) LPCAT4 AGPAT7 AYTL3 LPEAT2 Homo sapiens (Human) phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity [GO:0047166]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipid acyltransferase activity [GO:0071617] VALEPQLWELGKVLRK 1 3.1 0.44932 0.19156 0 0 0 0 7.11801 0 0 0 0 0 0 0 Q64LD2 WDR25_HUMAN WD repeat-containing protein 25 WDR25 C14orf67 Homo sapiens (Human) VLMYSFR 1 1.3 0.93704 -0.55357 0 8.54059 0 0 0 0 0 0 0 0 0 0 Q658L1 SAXO2_HUMAN Stabilizer of axonemal microtubules 2 SAXO2 FAM154B Homo sapiens (Human) axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] VQPVAIVRPLERQVKK;VTQNALFEGSTEFR 2 7.5 0.015564 0.76115 0 0 0 0 4.78015 0 0 0 0 0 9.45701 0 Q658N2 WSCD1_HUMAN Sialate:O-sulfotransferase 1 (WSC domain-containing protein 1) WSCD1 KIAA0523 Homo sapiens (Human) Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] DAMDSSVCGQDPEAQRLAEYCEVYQTPVQDTRCTDR;GRRSHDPEPFTPEMK;GWECYCAYPTPR;LLCVENNK;LLCVENNKEGSFRR;SLVAEFNR 6 14.8 0.97442 -3.8307 0 0 0 6.92303 11.0369 0 0 0 9.84194 10.4762 0 0 Q658P3 STEA3_HUMAN Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) STEAP3 TSAP6 Homo sapiens (Human) apoptotic process [GO:0006915]; copper ion import [GO:0015677]; iron ion transport [GO:0006826]; protein secretion [GO:0009306] cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886] cupric reductase (NADH) activity [GO:0008823]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GTKYQRFPDWLDHWLQHR 1 3.7 0.95855 -1.0041 0 0 0 0 0 0 0 0 0 0 0 9.04448 Q658Y4 F91A1_HUMAN Protein FAM91A1 FAM91A1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041] cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802] NLIFKDGVLSEWSGR 1 1.8 0.91841 -0.43641 0 0 0 0 0 9.82133 0 0 0 0 0 0 Q659A1 ICE2_HUMAN Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) ICE2 BRCC1 NARG2 UNQ3101/PRO10100 Homo sapiens (Human) positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] SLDTTTQQK;VIYINSPLPQKKMTMR;VKTTIGMVLLPKPRVPYPR 3 4.5 0.9673 -1.3132 0 6.79896 0 0 0 0 0 0 9.59291 0 0 0 Q659C4 LAR1B_HUMAN La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) LARP1B LARP2 Homo sapiens (Human) mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA cap binding [GO:0000339] HSSTSGEESNR;ILIVTQTPPYVKKHPGGDR;QIEYYFSVENLER;REIFQDFQEETK;TPRFYPVVKEPK;YGLECLFR 6 8.2 0.9805 -1.6118 0 0 8.74191 9.41659 0 9.6667 14.7642 9.18225 6.71315 17.419 17.4063 0 Q659C4 LAR1B_HUMAN La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) LARP1B LARP2 Homo sapiens (Human) mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA cap binding [GO:0000339] HSSTSGEESNR;ITGQLYGLEKFWAYLK 2 21.8 0.91488 -0.43427 0 0 0 0 0 8.40395 0 0 0 0 0 0 Q659C4 LAR1B_HUMAN La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) LARP1B LARP2 Homo sapiens (Human) mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA cap binding [GO:0000339] ENYRSAVWTRK;ILIVTQTPPYVKKHPGGDR;QIEYYFSVENLER;TPRFYPVVKEPK 4 7 0.8659 -0.089059 0 0 9.44925 0 0 0 0 0 0 0 0 0 Q66GS9 CP135_HUMAN Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) CEP135 CEP4 KIAA0635 Homo sapiens (Human) centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-motile cilium assembly [GO:1902857] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; tubulin binding [GO:0015631] KQLSNER;LLTAERDK;LQDDLATMAR;LSAVKAEK;NLESLLATNR;SESDLLKKQLSNER;TPEKGDYNSEIHQITRER 7 6 0.97488 -3.6175 0 0 11.7233 0 0 9.97011 0 0 0 10.9082 10.7049 0 Q66K14 TBC9B_HUMAN TBC1 domain family member 9B TBC1D9B KIAA0676 Homo sapiens (Human) membrane [GO:0016020] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] ETIKDLPK;HYLRMWAKEK 2 1.4 0.96616 -1.2839 0 0 0 0 8.32233 0 0 0 0 0 0 0 Q66K41 Z385C_HUMAN Zinc finger protein 385C ZNF385C Homo sapiens (Human) nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] HAALAVSILKSKLALQK;KLFISCNICHLR;VTGGRGGR 3 8.8 0.90969 -0.31667 0 0 0 5.46359 0 0 0 0 0 0 11.0294 13.9413 Q66K64 DCA15_HUMAN DDB1- and CUL4-associated factor 15 DCAF15 C19orf72 Homo sapiens (Human) immune system process [GO:0002376]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of natural killer cell activation [GO:0032814] Cul4-RING E3 ubiquitin ligase complex [GO:0080008] metal ion binding [GO:0046872]; small molecule binding [GO:0036094] DIYVSTVAVPPPGR;ISGQLSPR;QLERVKISGQLSPR 3 4.7 0.95292 -0.73691 0 0 0 0 0 9.81125 0 2.90423 0 0 0 0 Q66K66 TM198_HUMAN Transmembrane protein 198 TMEM198 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] VQLMRIR;VTAEGDSHTEVVISRQR 2 6.7 0.95498 -0.8789 0 13.533 0 0 10.5755 0 0 0 0 0 0 0 Q66K74 MAP1S_HUMAN Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1 Homo sapiens (Human) apoptotic process [GO:0006915]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite development [GO:0016358]; metaphase chromosome alignment [GO:0051310]; microtubule anchoring at centrosome [GO:0034454]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; regulation of microtubule depolymerization [GO:0031114] cell junction [GO:0030054]; cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule organizing center [GO:0005815]; mitotic spindle microtubule [GO:1990498]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; synapse [GO:0045202] actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] APLSRKSSTPK;GIRSWDVDPGVCNLDEQLK;LAERSEVAAGGGSWDDR;SSTPKTATRGPSGSASSRPGVSATPPK;VLFPGCTPPACLLDGLVRLQHLR 5 8.7 0.97439 -3.7879 8.70134 0 8.39562 10.516 0 0 10.9502 9.83616 0 0 0 0 Q66K79 CBPZ_HUMAN Carboxypeptidase Z (CPZ) (EC 3.4.17.-) CPZ Homo sapiens (Human) peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] LAETRGAR;VAPETKAIMK 2 3.5 0.9736 -1.4028 0 0 0 0 2.6573 0 0 0 0 0 0 12.185 Q66LE6 2ABD_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) PPP2R2D KIAA1541 Homo sapiens (Human) cell division [GO:0051301]; exit from mitosis [GO:0010458]; mitotic cell cycle [GO:0000278]; regulation of chromosome segregation [GO:0051983] cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159] enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase regulator activity [GO:0019888] INKIRWLPQQNAAHFLLSTNDK;LCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFR 2 12.6 0.89596 -0.24205 0 0 0 0 0 0 0 0 0 0 10.9019 0 Q66PJ3 AR6P4_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37) ARL6IP4 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] RNA binding [GO:0003723] EEWDARQSIIR;SSSSSSSSSSSSSSSSSSSSSSSSSDGR 2 16.5 0.95253 -0.67196 0 0 0 0 0 0 0 0 0 0 3.61247 0 Q674R7 ATG9B_HUMAN Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) ATG9B APG9L2 NOS3AS Homo sapiens (Human) autophagosome assembly [GO:0000045]; bone morphogenesis [GO:0060349]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phospholipid scramblase activity [GO:0017128] AYRQMAQLLQYR;FLGHLWGR;SSPLLVLLLVLAAGFWLVQLLR;VGPLIPEQDYER 4 5.8 0.9653 -1.2196 8.34576 0 0 5.39273 0 0 0 0 0 0 0 11.9915 Q674R7 ATG9B_HUMAN Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) ATG9B APG9L2 NOS3AS Homo sapiens (Human) autophagosome assembly [GO:0000045]; bone morphogenesis [GO:0060349]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phospholipid scramblase activity [GO:0017128] GQPGGLD;SSPLLVLLLVLAAGFWLVQLLR;VGPLIPEQDYER 3 12.1 0.70968 0.15865 0 0 6.99039 0 0 0 0 0 0 0 0 0 Q674X7 KAZRN_HUMAN Kazrin KAZN C1orf196 KAZ KIAA1026 HRIHFB2003 Homo sapiens (Human) keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] KLRLAIEDYR 1 1.3 0.77092 0.054475 0 0 0 0 8.96953 0 0 0 0 0 0 0 Q674X7 KAZRN_HUMAN Kazrin KAZN C1orf196 KAZ KIAA1026 HRIHFB2003 Homo sapiens (Human) keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] MKEMLAKDLEESQGGK;SLDPGLFDGTAPDYYIEEDADW 2 11.6 0.1021 0.36497 0 6.30783 0 0 0 0 0 0 0 0 10.0693 0 Q676U5 A16L1_HUMAN Autophagy-related protein 16-1 (APG16-like 1) ATG16L1 APG16L UNQ9393/PRO34307 Homo sapiens (Human) autophagosome assembly [GO:0000045]; axonal transport [GO:0098930]; C-terminal protein lipidation [GO:0006501]; corpus callosum development [GO:0022038]; defense response to virus [GO:0051607]; hippocampus development [GO:0021766]; macroautophagy [GO:0016236]; microautophagy [GO:0016237]; negative stranded viral RNA replication [GO:0039689]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; xenophagy [GO:0098792] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095] GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like protein transferase activity [GO:0019787] LQRQAFEEIILQYNK 1 2.5 0.81719 -0.01681 0 0 0 0 0 0 0 11.4495 0 0 0 0 Q685J3 MUC17_HUMAN Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3) MUC17 MUC3 Homo sapiens (Human) cellular homeostasis [GO:0019725] apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] "extracellular matrix constituent, lubricant activity [GO:0030197]; PDZ domain binding [GO:0030165]" HIDPETK 1 0.2 0.90912 -0.30969 0 0 0 0 0 0 9.72446 0 0 0 0 0 Q687X5 STEA4_HUMAN "Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)" STEAP4 STAMP2 TNFAIP9 Homo sapiens (Human) copper ion import [GO:0015677]; fat cell differentiation [GO:0045444]; iron import into cell [GO:0033212]; protein homotrimerization [GO:0070207] early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cupric reductase (NADH) activity [GO:0008823]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; metal ion binding [GO:0046872] FLSPSNLR;MAISIPNR;TTLLPSGAEVLSYSEAAK 3 7.4 0.7945 0.015708 0 0 0 0 0 0 0 12.2483 11.6918 11.7796 11.7812 0 Q68BL7 OLM2A_HUMAN Olfactomedin-like protein 2A (Photomedin-1) OLFML2A UNQ9394/PRO34319 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802] AAAALPPRPLLLLPLVLLLSGRPTR;ALAQQQAVIRGFTYYKAGK;CSCTAPPSSLNPCENEWKMEK;HEGAWMKDPAARDDR;LDPGDLSVHRETTWK;MAAAALPPRPLLLLPLVLLLSGRPTR;MTSEGSDCR;NLENFKQGRWSNMYK;YGSVQKSFADRGLPKPPK 9 21.2 0.97782 -2.1645 0 11.2798 3.6472 0 0 4.98003 0 10.4066 0 0 10.2041 0 Q68BL8 OLM2B_HUMAN Olfactomedin-like protein 2B (Photomedin-2) OLFML2B Homo sapiens (Human) extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802] SQRPLQRQVHLR 1 1.6 0.83724 -0.032444 0 0 0 5.41566 0 0 0 0 0 0 0 0 Q68CJ6 SLIP_HUMAN Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center) NUGGC C8orf80 HMFN0672 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; negative regulation of apoptotic process [GO:0043066]; regulation of nuclear cell cycle DNA replication [GO:0033262] nuclear speck [GO:0016607] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AGPPGTSL;EVAENARLR;LESRTRR;RDWDGEAAEMR 4 4.4 0.97284 -2.9207 12.0778 0 11.9081 7.3856 8.89697 0 0 0 11.0362 11.8766 0 7.91085 Q68CJ9 CR3L3_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] CREB3L3 CREBH HYST1481 Homo sapiens (Human) positive regulation of acute inflammatory response [GO:0002675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" VLHLEKQNLSLLEQLKK 1 3.7 0.55513 0.18293 0 0 0 0 0 4.49108 0 0 0 8.97106 0 0 Q68CK6 ACS2B_HUMAN "Acyl-coenzyme A synthetase ACSM2B, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2B) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A)" ACSM2B ACSM2 HYST1046 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; xenobiotic metabolic process [GO:0006805] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872] LQMSKAK;TLYINSR;VPEWWLVILGCIRAGLIFMPGTIQMKSTDILYR 3 8.1 0.9782 -1.9768 7.50398 5.33785 0 0 0 0 9.7288 11.0513 0 10.1518 0 0 Q68CL5 TPGS2_HUMAN Tubulin polyglutamylase complex subunit 2 (PGs2) TPGS2 C18orf10 HMFN0601 L17 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] KKGPVQPAGGQK 1 4 0.86579 -0.091952 0 7.46972 0 0 0 0 0 0 0 0 0 0 Q68CL5 TPGS2_HUMAN Tubulin polyglutamylase complex subunit 2 (PGs2) TPGS2 C18orf10 HMFN0601 L17 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] ITYNIKMNR 1 3 0.90277 -0.263 0 0 0 0 0 0 0 10.676 0 0 0 0 Q68CP4 HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) heparan sulfate proteoglycan catabolic process [GO:0030200]; lysosomal transport [GO:0007041]; protein complex oligomerization [GO:0051259] lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] acyltransferase activity [GO:0016746]; heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] ASAAEQRRAGR;EVCRLEYRFGEFGNYSLLVK;ILLYYKARTK;LLLSLDDFNNWISK 4 8.3 0.95598 -0.86976 9.03025 0 0 9.80919 0 0 0 0 0 0 9.43133 0 Q68CP9 ARID2_HUMAN AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) ARID2 BAF200 KIAA1557 Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; chromatin remodeling [GO:0006338]; coronary artery morphogenesis [GO:0060982]; embryonic organ development [GO:0048568]; heart morphogenesis [GO:0003007]; homeostatic process [GO:0042592]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CLYELNFTVQSKEQEK;KGLAFLDELRQFHHSR;MRGMEILGNLCK;QRFSFITHLQDKHCSK;QYYLRYLEKYEK 5 3.9 0.95505 -0.9731 0 6.28064 0 9.96006 8.42152 3.62504 0 8.15158 0 0 0 11.4995 Q68CQ1 MROH7_HUMAN Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8) MROH7 C1orf175 HEATR8 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] DLLLAALEGLKGSSEAPGK;GAQPSPFVPVRWVVKVVK;SSCINLYGK;TLLRCSYFMAWELPK;TLLRCSYFMAWELPKR;VLSIRGLVILARR;WVVKVVKTLLLR 7 6 0.95759 -1.0285 9.39204 0 7.32067 0 8.20114 7.42459 10.8731 10.1208 6.62644 0 7.70266 0 Q68CQ1 MROH7_HUMAN Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8) MROH7 C1orf175 HEATR8 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] DAVTLQGIPEGVSGSSWTFPA 1 5 0.78377 0.023501 0 0 0 8.52066 0 0 0 0 0 0 0 0 Q68CQ4 UTP25_HUMAN U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) UTP25 C1orf107 DEF DIEXF Homo sapiens (Human) "embryonic organ development [GO:0048568]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of embryonic development [GO:0040019]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to nucleolus [GO:1902570]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; U3 snoRNA binding [GO:0034511] FNFFVNK;HVYCLHVINHILK;LETFKPPKDIDLKSLHLQKPLESTWTK;WPILGQLFFSSKFQK 4 8.2 0.97265 -2.7392 0 0 0 0 0 0 10.974 0 0 7.56102 0 0 Q68CQ7 GL8D1_HUMAN Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-) GLT8D1 GALA4A AD-017 MSTP137 UNQ572/PRO1134 Homo sapiens (Human) Golgi apparatus [GO:0005794]; membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] WYIPDPTGK 1 2.4 0.90966 -0.31557 0 0 0 0 10.4213 0 0 0 0 0 0 0 Q68CR1 SE1L3_HUMAN Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3) SEL1L3 KIAA0746 Homo sapiens (Human) membrane [GO:0016020] TKFIIPLK 1 0.7 0.91377 -0.33804 0 10.2411 0 0 0 0 0 0 0 0 0 0 Q68CR7 LRC66_HUMAN Leucine-rich repeat-containing protein 66 LRRC66 Homo sapiens (Human) long-term memory [GO:0007616] plasma membrane [GO:0005886] MKNLYFR 1 0.8 0.90349 -0.26471 0 0 8.40207 0 6.34763 0 0 0 6.24235 0 0 0 Q68CZ1 FTM_HUMAN Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) cerebellum development [GO:0021549]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589]; retinal rod cell development [GO:0046548] axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886] thromboxane A2 receptor binding [GO:0031870] FIQLQEKQR;LYRERAK 2 1.2 0.93712 -0.5432 0 0 0 7.80716 0 0 0 0 0 0 0 9.30058 Q68CZ2 TENS3_HUMAN Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) TNS3 TEM6 TENS1 TPP Homo sapiens (Human) positive regulation of Rac protein signal transduction [GO:0035022] cell projection [GO:0042995]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102] phosphoprotein phosphatase activity [GO:0004721] AGDLANELVR;DKEPGSFIVRDSHSFR 2 1.8 0.9806 -1.6292 0 0 0 0 0 0 0 10.2863 0 0 0 0 Q68CZ6 HAUS3_HUMAN HAUS augmin-like complex subunit 3 HAUS3 C4orf15 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule organizing center organization [GO:0031023]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498] KELFLTHGNLEEVAEK 1 2.7 0.30307 0.25009 0 0 0 0 0 0 5.38367 0 0 0 0 0 Q68D06 SLN13_HUMAN Schlafen family member 13 (EC 3.1.-.-) (Schlafen-13) (hSLFN13) SLFN13 Homo sapiens (Human) defense response to virus [GO:0051607]; rRNA catabolic process [GO:0016075]; tRNA decay [GO:0016078] cytoplasm [GO:0005737] ATP binding [GO:0005524]; RNA endonuclease activity [GO:0004521]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] AETRETFLREK;SGTSVLHMNSRQAFDFLK;TIMAMKIMEK;TIMAMKIMEKIR;VLGCAKEQVDPDSLK 5 6.2 0.97352 -2.4716 0 0 0 6.82769 0 0 6.67073 0 8.61143 0 0 9.1749 Q68D20 PMS2L_HUMAN Protein PMS2CL (PMS2-C terminal-like protein) PMS2CL PMS2P13 Homo sapiens (Human) APETDDSFSDVDCHSNQEDTGCK 1 11.9 0.70204 0.16126 0 0 0 0 0 0 0 0 0 0 0 3.7277 Q68D51 DEN2C_HUMAN DENN domain-containing protein 2C DENND2C Homo sapiens (Human) nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] ISQWEGR;KNLPRLVLK;KSHTSRSVR;KSKNLDVTSR;LPEVYCMVSRLGCFNLFSK;WCPKDFGVR;WFGYCKKLLPVGK;YLSESGVTPYKER 8 9.6 0.97608 -4.5601 0 0 9.04854 6.30073 8.88059 8.76977 0 0 2.83798 0 10.8617 11.8615 Q68D86 C102B_HUMAN Coiled-coil domain-containing protein 102B CCDC102B C18orf14 Homo sapiens (Human) centriole-centriole cohesion [GO:0010457] centriole [GO:0005814]; cytoplasm [GO:0005737] protein serine/threonine kinase binding [GO:0120283] AERNSAREEGR;SLDEEKERNENLETELR 2 5.5 0.95462 -0.95184 0 0 0 0 0 0 0 0 0 8.20134 10.0959 0 Q68DA7 FMN1_HUMAN Formin-1 (Limb deformity protein homolog) FMN1 FMN LD Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; forelimb morphogenesis [GO:0035136]; gene expression [GO:0010467]; hindlimb morphogenesis [GO:0035137]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of actin nucleation [GO:0051127]; positive regulation of focal adhesion assembly [GO:0051894]; skeletal system morphogenesis [GO:0048705]; ureteric bud invasion [GO:0072092] actin filament [GO:0005884]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin binding [GO:0003779]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124] AGPACPFLLHEER;ESPKEYLQPFK;LTTERER;QLEASEKQMVVVCK;VVKTHSK;VVKTHSKGK 6 3.8 0.9749 -3.1596 12.8534 0 0 0 0 0 0 0 0 0 9.35032 11.1472 Q68DA7 FMN1_HUMAN Formin-1 (Limb deformity protein homolog) FMN1 FMN LD Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; forelimb morphogenesis [GO:0035136]; gene expression [GO:0010467]; hindlimb morphogenesis [GO:0035137]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of actin nucleation [GO:0051127]; positive regulation of focal adhesion assembly [GO:0051894]; skeletal system morphogenesis [GO:0048705]; ureteric bud invasion [GO:0072092] actin filament [GO:0005884]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin binding [GO:0003779]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124] ESPKEYLQPFK;LESVNPEEEDAVLK;LTQPVQK;QLEASEKQMVVVCK 4 3.8 0.90903 -0.30095 0 0 0 9.50438 0 8.23089 0 0 11.4444 6.97499 0 10.2699 Q68DC2 ANKS6_HUMAN Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) ANKS6 ANKRD14 PKDR1 SAMD6 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822] ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737] LLASVCMQVNKDK;VRQPWSIPVLPDDK 2 3.1 0.95374 -0.89129 0 0 0 0 0 0 0 0 9.9268 0 3.96033 0 Q68DC2 ANKS6_HUMAN Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) ANKS6 ANKRD14 PKDR1 SAMD6 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822] ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737] VQPCRPLR 1 2.4 0.92094 -0.44444 0 0 0 0 0 0 11.8775 0 0 0 0 0 Q68DD2 PA24F_HUMAN Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF) PLA2G4F Homo sapiens (Human) arachidonate secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; cellular response to organic cyclic compound [GO:0071407]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; prostaglandin biosynthetic process [GO:0001516] cytosol [GO:0005829]; mitochondrion [GO:0005739]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970] LGFDLSDGEQEFLDRR;MLPLLGAVLLQK;VEMSSGDLDLR;VLRATNIRGTDLLSK 4 6.4 0.97312 -2.4964 0 0 0 0 0 0 9.28052 0 10.4764 0 0 10.3103 Q68DE3 USF3_HUMAN Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3) USF3 KIAA2018 Homo sapiens (Human) negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LNKKPGGR;NRETHNAVERHR 2 0.9 0.9668 -1.2876 0 0 0 0 0 7.91079 0 0 0 0 0 0 Q68DH5 LMBD2_HUMAN G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2) LMBRD2 Homo sapiens (Human) adrenergic receptor signaling pathway [GO:0071875] membrane [GO:0016020]; plasma membrane [GO:0005886] CPTEYQEKMGRNMDDYEDFDEK 1 3.2 0.56042 0.18276 0 0 0 0 0 0 0 0 0 0 5.32229 0 Q68DI1 ZN776_HUMAN Zinc finger protein 776 ZNF776 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECGKCFHQK;THWTGVCTKK 2 5.4 0.91683 -0.35569 0 0 0 0 0 0 9.39735 0 0 5.27404 0 0 Q68DK2 ZFY26_HUMAN Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) ZFYVE26 KIAA0321 Homo sapiens (Human) autophagosome organization [GO:1905037]; double-strand break repair via homologous recombination [GO:0000724]; lysosome organization [GO:0007040]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; midbody [GO:0030496] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901] HHCRRCGR;ILGLQSPPVWCDWQTLR;IYLQETSR;LLQEQLDEISSR;LSKVVSEAQWR;NESPPYSFVVRVPK;RSQADGRDR;VCDQCYSYCNK;VSPDHLDPERAMLALFSNPNPAEAWK 9 4.6 0.97664 -2.2771 0 0 0 0 9.09196 6.54283 0 8.05815 0 12.2467 0 0 Q68DL7 CR063_HUMAN Uncharacterized protein C18orf63 C18orf63 Homo sapiens (Human) GITQILGKSHGSLKLK;LPAPELK;TFTYPLSCIRSQPMQFFPR;TIQMKMCR 4 7.3 0.91823 -0.40458 8.81558 8.08481 9.4257 0 12.1488 0 0 5.46943 10.5293 0 0 0 Q68DN1 S31H1_HUMAN Spermatogenesis-associated protein 31H1 SPATA31H1 C2orf16 Homo sapiens (Human) extracellular exosome [GO:0070062]; nucleus [GO:0005634] ILPGSPVK;LTPAGSTIKQEDILWGGTVQCRSAQQPR;RQPKKPSQPK;SLEFTVEPKLQSVKHVK;SSLERRHHSPSQR;SVGLTPK 6 4.2 0.9664 -1.2828 9.92831 10.884 0 0 7.80806 0 0 11.9405 9.44141 8.2181 0 14.5461 Q68DQ2 CRBG3_HUMAN Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) CRYBG3 Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; protein kinase A binding [GO:0051018]; structural constituent of eye lens [GO:0005212] ANMSIIEK;ENSLTNNPELQNIASSNNLLNK;ETDYSDK;IGESDRQPK;LEMENTYPKDTER;LEMENTYPKDTERDGGK;MKDTEGDIGK;SDSLSLEAK;SPPPSFCLEYTSAIFEFK;TGTIALSEVENIHQKGGEGISEK;TIGSLRPMKQPAVYIRIK;VIGGVWVAYEK 12 5.1 0.97579 -4.4022 0 11.5467 7.45269 6.19674 12.8114 0 0 13.4307 8.4261 10.325 0 12.7666 Q68DU8 KCD16_HUMAN BTB/POZ domain-containing protein KCTD16 (Potassium channel tetramerization domain-containing protein 16) KCTD16 KIAA1317 Homo sapiens (Human) protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; identical protein binding [GO:0042802] CIQDFLKIKIPDR;WSPSHCDCCCK 2 5.6 0.97356 -1.4154 0 0 0 0 0 3.82344 0 0 0 0 0 0 Q68DX3 FRPD2_HUMAN FERM and PDZ domain-containing protein 2 (PDZ domain-containing protein 4) (PDZ domain-containing protein 5C) FRMPD2 PDZD5C PDZK4 PDZK5C Homo sapiens (Human) bicellular tight junction assembly [GO:0070830] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 1-phosphatidylinositol binding [GO:0005545] EFFFLDSETR;FQWRETGK;GVIVYEVKNNSR 3 2.3 0.98078 -1.7921 7.10633 6.81224 0 0 6.01683 0 0 0 0 0 0 0 Q68DY1 ZN626_HUMAN Zinc finger protein 626 ZNF626 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEECGKAFNHSCSLTR;KICQCDKYVK;VLHQFPNSNGQKR 3 7.4 0.94577 -0.65119 0 0 3.47262 10.1736 7.46532 7.59865 0 0 0 3.48156 0 0 Q68E01 INT3_HUMAN Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) INTS3 C1orf193 C1orf60 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to ionizing radiation [GO:0010212]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876] DESCYDNAEAAFSDDEEDLNSK;KAALSSPRSR;LAQLTLEQILEHLDNLRLNLTNTK;NIWLAESVLDILTEQR;QSLRSSSSKLAQLTLEQILEHLDNLR 5 7.8 0.98078 -2.0245 3.89908 8.35275 0 0 9.8609 0 0 0 0 6.29343 0 0 Q68EA5 ZNF57_HUMAN Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LYKCEHCGK;NCEGYGTEDHHKNLR 2 4.3 0.9651 -1.122 0 0 0 0 0 0 0 0 0 0 0 8.56989 Q68EM7 RHG17_HUMAN Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) ARHGAP17 RICH1 MSTP066 MSTP110 Homo sapiens (Human) actin filament organization [GO:0007015]; calcium-ion regulated exocytosis [GO:0017156]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] KLQDLWRTCQK;LVLDWDSVR;MKQLANQTVGRAEK 3 3.9 0.97522 -2.3738 0 0 0 0 0 0 0 11.5368 0 10.9781 0 0 Q68G74 LHX8_HUMAN LIM/homeobox protein Lhx8 (LIM homeobox protein 8) LHX8 Homo sapiens (Human) female gonad development [GO:0008585]; forebrain neuron development [GO:0021884]; learning or memory [GO:0007611]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" CGRHIHSTDWVR;GNVYHLACFACFSCK 2 7.6 0.9528 -0.73607 0 0 6.89373 0 0 0 0 0 10.3873 0 0 0 Q68G75 LEMD1_HUMAN LEM domain-containing protein 1 (Cancer/testis antigen 50) (CT50) (LEM domain protein 1) (LEMP-1) LEMD1 Homo sapiens (Human) membrane [GO:0016020] AVDTYCLDYKPSK 1 7.2 0.80478 0.013912 0 0 0 0 0 0 0 5.23216 0 0 0 0 Q68J44 DUS29_HUMAN "Dual specificity phosphatase 29 (Dual specificity phosphatase 27) (Dual specificity phosphatase DUPD1) (EC 3.1.3.16, EC 3.1.3.48)" DUSP29 DUPD1 DUSP27 Homo sapiens (Human) glucose homeostasis [GO:0042593]; muscle cell differentiation [GO:0042692]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" ELDKQLVQQRR 1 5 0.86593 -0.089122 0 0 0 0 0 0 0 0 0 0 4.63436 0 Q693B1 KCD11_HUMAN BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11) KCTD11 C17orf36 REN Homo sapiens (Human) positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] identical protein binding [GO:0042802]; transferase activity [GO:0016740] HILNFLRLGRLDLPR 1 6.5 0.96536 -1.1583 0 0 0 0 0 10.5457 0 0 0 0 0 0 Q69YH5 CDCA2_HUMAN Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) CDCA2 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; regulation of chromosome segregation [GO:0051983]; regulation of mitotic nuclear division [GO:0007088] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein phosphatase regulator activity [GO:0019888] GGTPVCK 1 0.7 0.78366 0.026462 0 0 0 0 0 0 0 0 0 0 0 11.233 Q69YI7 NAIF1_HUMAN Nuclear apoptosis-inducing factor 1 NAIF1 C9orf90 Homo sapiens (Human) negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] EVEIIVEELELK 1 3.7 0.80425 0.012629 8.27305 0 0 0 0 0 0 0 0 0 0 0 Q69YL0 NCAS2_HUMAN Protein NCBP2AS2 (Hypoxia-induced angiogenesis regulator) (NCBP2 antisense gene protein 2) NCBP2AS2 HIAR Homo sapiens (Human) mitochondrion [GO:0005739] DAFTQELRR 1 9.1 0.78421 0.031007 9.68569 0 0 0 0 0 0 0 0 0 0 0 Q69YN2 C19L1_HUMAN CWF19-like protein 1 (C19L1) CWF19L1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" post-mRNA release spliceosomal complex [GO:0071014] RNA lariat debranching enzyme activator activity [GO:0061632] FDILFNRVQAIQKK 1 2.6 0.50085 0.18898 0 0 0 0 0 5.80258 0 0 0 0 0 0 Q69YN4 VIR_HUMAN Protein virilizer homolog VIRMA KIAA1429 MSTP054 Homo sapiens (Human) mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] RNA binding [GO:0003723] ELVPLLYFSCPYK;ILLEEITMK 2 1.2 0.95541 -0.87638 0 0 0 7.44186 0 0 0 0 0 0 0 0 Q69YQ0 CYTSA_HUMAN Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) SPECC1L CYTSA KIAA0376 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell division [GO:0051301] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; gap junction [GO:0005921]; microtubule organizing center [GO:0005815]; spindle [GO:0005819] LQDAIAK;QEEERGR;RLREESAEWR;SDMKETIFELEDEVEQHRAVK;SHHMERIIESEQKGK;TEGYQRR;VPAMESAK 7 7 0.97414 -2.4592 0 0 12.264 3.97728 0 0 10.0725 0 0 0 11.5625 0 Q69YW2 STUM_HUMAN Protein stum homolog STUM C1orf95 Homo sapiens (Human) membrane [GO:0016020] GASSSSGVVVQVREK 1 10.6 0.9184 -0.43582 0 0 0 0 0 0 0 0 0 0 9.85706 0 Q6A162 K1C40_HUMAN "Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)" KRT40 KA36 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] YFNTIEDLQQKILCTKAENSR 1 4.9 0.86431 -0.083824 0 0 0 0 0 0 0 0 0 6.28612 0 0 Q6AHZ1 Z518A_HUMAN Zinc finger protein 518A ZNF518A KIAA0335 ZNF518 Homo sapiens (Human) chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CHHVCFTKGELQK;INSGSDRSIEK;ISGSIHYALKNVK;TAVLGPTLKNVMMKNNK;TKTHGSK;TTYDDFSKR;VNNSNKR;YEKRMAK 8 5.7 0.97197 -2.7193 0 4.67095 11.5442 0 9.12766 8.94122 0 10.1075 10.5942 11.4375 8.70874 4.51242 Q6AI08 HEAT6_HUMAN HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) HEATR6 ABC1 Homo sapiens (Human) RNA binding [GO:0003723] EDSCSGSDAGSAAGSTYEPSPMR;LSDLAQSDPEVRR;LSLLTKVWNQIKPYIRHK;MALKHMGSIQAPTGDTARR 4 6.2 0.34119 0.23914 0 0 0 0 0 0 12.1741 0 0 11.4923 6.95548 11.5049 Q6AI14 SL9A4_HUMAN Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) SLC9A4 NHE4 Homo sapiens (Human) gastric acid secretion [GO:0001696]; glandular epithelial cell development [GO:0002068]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; transepithelial ammonium transport [GO:0070634] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] LSPEDVESIR 1 1.3 0.88575 -0.1821 0 0 0 0 0 0 0 0 0 0 0 11.2117 Q6AI39 BICRL_HUMAN BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) BICRAL GLTSCR1L KIAA0240 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514] ASSSLQPPAKAQGRDR;VDNEFETVATQLLKRTQAMLNK 2 3.5 0.97513 -1.4372 0 0 9.94653 11.4207 0 0 0 0 0 0 0 0 Q6AW86 Z324B_HUMAN Zinc finger protein 324B ZNF324B Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VRRGGKPSPVLKPAK 1 2.8 0.96217 -1.0788 0 0 0 0 4.43035 0 0 0 0 0 0 0 Q6AWC2 WWC2_HUMAN Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) WWC2 BOMB Homo sapiens (Human) cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] DLRQKLEELK;ISIPSLPADDV;NLHAFLIPHTSKVYFR;QVSKDVCR 4 3.8 0.97403 -2.4131 0 0 4.06186 9.84188 0 0 0 10.7596 0 0 0 0 Q6AWC8 YK026_HUMAN Putative uncharacterized protein LOC100129027 Homo sapiens (Human) LVLGQMVQAVRR 1 8.2 0.73503 0.1102 0 0 0 0 0 0 0 13.2988 13.2479 0 0 0 Q6AZY7 SCAR3_HUMAN Scavenger receptor class A member 3 (Cellular stress response gene protein) SCARA3 CSR Homo sapiens (Human) response to oxidative stress [GO:0006979]; UV protection [GO:0009650] collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] scavenger receptor activity [GO:0005044] KTDEETLTLQK;SVSIMLGTTDLLRERFSLLSAR 2 7.1 0.23591 0.29411 0 0 0 8.9697 9.19997 0 0 0 0 0 0 0 Q6AZZ1 TRI68_HUMAN E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68) TRIM68 GC109 RNF137 SS56 Homo sapiens (Human) innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LDPDTAYSRLIVSEDR;LHPGMGLKGDLCERHGEK;RTATWKIQVETR;SWSLQQPEPISLELKTDCR 4 13.4 0.97236 -2.7556 0 0 0 8.87578 3.09776 0 10.7821 12.9089 0 0 0 7.2891 Q6B0B8 TIGD3_HUMAN Tigger transposable element-derived protein 3 TIGD3 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] TPPSSHK 1 1.5 0.82327 -0.01793 0 0 0 0 0 0 0 0 0 0 8.54894 0 Q6B0I6 KDM4D_HUMAN Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D) KDM4D JHDM3D JMJD2D Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; inflammatory response [GO:0006954]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; regulation of gene expression [GO:0010468]; regulation of protein phosphorylation [GO:0001932] blood microparticle [GO:0072562]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861] chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; histone demethylase activity [GO:0032452]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872] IIPPKEWKAR;VTFSMDAFVRILQPER;VTFSMDAFVRILQPERYDLWK 3 5.9 0.97788 -1.5014 0 0 0 5.1637 0 7.72199 0 0 0 8.60752 0 0 Q6BAA4 FCRLB_HUMAN Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY) FCRLB FCRL2 FCRLM2 FCRY FREB2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of immune response [GO:0050777] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] EMQLLKGLLSRVVLELK;YQCSGTMR 2 5.9 0.48574 0.18995 0 0 0 0 0 7.34563 0 0 0 0 8.33244 0 Q6BAA4 FCRLB_HUMAN Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY) FCRLB FCRL2 FCRLM2 FCRY FREB2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of immune response [GO:0050777] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] GAPLRLGR;VHSPGAR;VLQVQPR;YQCSGTMR 4 11.2 0.91725 -0.40945 0 10.0717 0 0 0 0 6.27828 0 0 7.25522 10.7261 0 Q6BDS2 BLT3A_HUMAN Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) BLTP3A C6orf107 UHRF1BP1 Homo sapiens (Human) late endosome [GO:0005770] histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802] ERAELHRPQALVFSASGMIATNTR;IEADATDNGDQDPVTTPLR;LDAFWLKVSFPLEK;LVMEFQSKMEK;TKDCNVISSK;VRLDHYQYLALLRLK;WQQAQARKLLLASEGR 7 7.6 0.012397 0.88194 5.82184 13.5335 14.1602 8.87169 0 0 11.0405 0 11.6452 0 11.6292 7.4614 Q6BEB4 SP5_HUMAN Transcription factor Sp5 SP5 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cellular response to organic cyclic compound [GO:0071407]; post-anal tail morphogenesis [GO:0036342]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VAEAGVKREDAR 1 3 0.76966 0.056811 0 0 0 0 8.99568 0 0 0 0 0 0 0 Q6DD87 ZN787_HUMAN Zinc finger protein 787 (TTF-I-interacting peptide 20) ZNF787 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" AGGEEEDDDDEAAGGRCPECRGGEGR 1 6.8 0.68444 0.16504 4.87828 0 0 0 0 0 0 0 0 5.42391 0 0 Q6DHV5 C2D2B_HUMAN Protein CC2D2B CC2D2B C10orf130 C10orf131 Homo sapiens (Human) non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491] ciliary transition zone [GO:0035869] ALTDATK;GKDLSLLHSILRTWK;HPTHWNR;LKISKINK;LNVRKEPLNPLLK;SYPKCFSLGVNLQNVAESEEEEFMK;TLRGKVR 7 5.7 0.97781 -1.5124 0 11.258 3.02565 10.6453 8.28021 0 0 9.22896 0 10.1538 5.50408 0 Q6DHV7 ADAL_HUMAN N6-Methyl-AMP deaminase (EC 3.5.4.-) (Adenosine deaminase-like protein) (N6-mAMP deaminase) (HsMAPDA) (N6-methyl-AMP aminohydrolase) MAPDA ADAL ADAL1 Homo sapiens (Human) adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]; nucleotide metabolic process [GO:0009117]; response to alcohol [GO:0097305] cytosol [GO:0005829] adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; N6-methyl-AMP deaminase activity [GO:0062154] KLIAQKPDLKIHDQMTVIDK 1 7.5 0.85218 -0.079704 0 0 0 0 0 0 0 7.85425 7.34616 0 0 0 Q6DKI1 RL7L_HUMAN Ribosomal protein uL30-like (60S ribosomal protein L7-like 1) (Large ribosomal subunit protein uL30-like 1) RPL7L1 Homo sapiens (Human) "blastocyst formation [GO:0001825]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" cytosolic large ribosomal subunit [GO:0022625]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KAYQALKATQAK 1 4.7 0.97524 -1.4403 9.26536 0 0 0 0 0 0 0 0 0 0 0 Q6DKI2 LEG9C_HUMAN Galectin-9C (Gal-9C) (Galectin-9-like protein B) LGALS9C Homo sapiens (Human) "negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]" cytosol [GO:0005829]; nucleus [GO:0005634] carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936] GTWGPEER 1 2.2 0.9369 -0.56299 0 0 0 0 0 0 0 0 0 0 8.48071 0 Q6DKJ4 NXN_HUMAN Nucleoredoxin (EC 1.8.1.8) NXN NRX Homo sapiens (Human) cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; in utero embryonic development [GO:0001701]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] QWQDFVRDMPWLALPYK;VLVESYRKIK 2 6.2 0.98054 -1.665 0 7.16792 0 10.1392 0 0 0 0 0 0 0 0 Q6DN12 MCTP2_HUMAN Multiple C2 and transmembrane domain-containing protein 2 MCTP2 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; regulation of neurotransmitter secretion [GO:0046928] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] GVIYLEMDLIYNPVK;GVIYLEMDLIYNPVKASIR;GVIYLEMDLIYNPVKASIRTFTPR;ILSRDVDR;QITQRYCLQNSLK;STIAFAHR 6 17.3 0.97482 -3.1916 0 8.70231 0 0 0 0 0 0 10.937 0 7.23372 0 Q6DN14 MCTP1_HUMAN Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; negative regulation of cell migration [GO:0030336]; negative regulation of endocytosis [GO:0045806]; negative regulation of response to oxidative stress [GO:1902883]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] DIHSVLEVTVYDEDRDR;DVTMLMR;LSKQLLLRNFIR 3 3.6 0.95506 -0.93906 0 0 0 0 0 8.59044 0 10.0475 0 0 0 0 Q6DN72 FCRL6_HUMAN Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6) FCRL6 FCRH6 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] MHC class II protein binding [GO:0042289]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; transmembrane signaling receptor activity [GO:0004888] FYRDGKFLHFSK;SEQDAGNYSCEAENSVSR 2 6.9 0.75043 0.078776 0 0 0 0 0 0 0 0 0 6.74241 5.74618 0 Q6DN90 IQEC1_HUMAN IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) IQSEC1 ARFGEP100 BRAG2 KIAA0763 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; dendritic spine development [GO:0060996]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; regulation of ARF protein signal transduction [GO:0032012] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021] guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] EIFLFNDLLVVTKIFQKK;GVQYLIER;GVVRPSMSQCSSLK;QMIGEFLGNR;RPKLQHSTSILRK;STPSLER;TIQTAFRQYQMNK 7 8.6 0.97915 -1.5356 11.4343 0 10.0835 9.08028 0 0 0 7.88374 0 0 5.62355 0 Q6DT37 MRCKG_HUMAN Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) CDC42BPG DMPK2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; protein phosphorylation [GO:0006468] cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AQGQQEELLQR;LELQSALEAEIR;LPEMLRDK;LQEAQER;RAETACFR;VSEEQQK 6 3.4 0.97254 -2.7506 5.21222 0 0 0 0 7.5766 6.6858 0 0 0 0 10.3516 Q6E0U4 DMKN_HUMAN Dermokine (Epidermis-specific secreted protein SK30/SK89) DMKN UNQ729/PRO1411 Homo sapiens (Human) cornified envelope assembly [GO:1903575] extracellular space [GO:0005615] AIIEGADASSLQK;EAGGAAGSK;LGFINWDAINK;LLGGSGDNYR;VSEALGQGTR 5 11.4 0.97818 -1.5107 0 0 0 9.7702 0 0 11.3842 10.0366 9.38258 0 7.83226 0 Q6E213 AWAT2_HUMAN Acyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (EC 2.3.1.20) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS) AWAT2 DC4 DGAT2L4 MFAT WS Homo sapiens (Human) acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]; retinoid metabolic process [GO:0001523]; wax biosynthetic process [GO:0010025] endoplasmic reticulum membrane [GO:0005789] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252] YSLPGSSTLVLKNRSGFVR 1 5.7 0.44287 0.1941 0 0 0 0 0 0 0 10.958 0 0 0 0 Q6EBC2 IL31_HUMAN Interleukin-31 (IL-31) IL31 Homo sapiens (Human) immune system process [GO:0002376] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] AYLKTIRQLDNK 1 7.3 0.86965 -0.094577 0 0 0 0 0 0 0 0 8.84543 0 0 0 Q6ECI4 ZN470_HUMAN Zinc finger protein 470 (Chondrogenesis zinc finger protein 1) (CZF-1) ZNF470 CZF1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GLCPDLECVWVTK 1 1.8 0.87347 -0.11403 0 0 0 9.61504 0 0 0 0 0 0 0 0 Q6EEV6 SUMO4_HUMAN Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4) SUMO4 SMT3H4 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA binding [GO:0043388]; protein sumoylation [GO:0016925]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein localization to nucleus [GO:1900180] nucleus [GO:0005634]; SUMO ligase complex [GO:0106068] protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389] LMKAYCEPR;QTPLSKLMKAYCEPR;VAGQDGSVVQFK 3 28.4 0 32.125 0 13.1071 13.112 0 0 0 0 0 9.2123 11.6663 11.6564 0 Q6EMB2 TTLL5_HUMAN Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5) TTLL5 KIAA0998 STAMP Homo sapiens (Human) protein modification process [GO:0036211]; retina development in camera-type eye [GO:0060041]; sperm axoneme assembly [GO:0007288] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" AGSCYLNKHHSGIAKTQK;NPFQKPQRCRPLSASDAEMK;VREWNNK 3 3.5 0.93315 -0.50755 0 0 0 7.0881 0 9.23242 0 9.28381 0 0 0 0 Q6F5E8 CARL2_HUMAN "Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)" CARMIL2 LRRC16C RLTPR Homo sapiens (Human) "actin filament network formation [GO:0051639]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of monopolar cell polarity [GO:0061339]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of cell migration [GO:0030335]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of ruffle assembly [GO:1900029]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877] EEEKEKDDSPPQK;SLCPQMLQGSSWR;SPVLKRRPK 3 2.4 0.97488 -1.4364 0 0 0 0 0 2.84559 0 0 0 0 8.44696 0 Q6FHJ7 SFRP4_HUMAN "Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)" SFRP4 FRPHE Homo sapiens (Human) bone morphogenesis [GO:0060349]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of sodium-dependent phosphate transport [GO:2000119]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; phosphate ion homeostasis [GO:0055062]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of receptor internalization [GO:0002092]; regulation of BMP signaling pathway [GO:0030510]; response to hormone [GO:0009725] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] Wnt-protein binding [GO:0017147] SRMMLLENCLVEK 1 3.8 0.92169 -0.44294 0 5.58388 0 0 0 0 0 0 0 0 0 0 Q6FI13 H2A2A_HUMAN Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) H2AC18 H2AFO HIST2H2AA HIST2H2AA3; H2AC19 HIST2H2AA4 Homo sapiens (Human) heterochromatin formation [GO:0031507] extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGLQFPVGR;HLQLAIR;KGNYAER;LLGKVTIAQGGVLPNIQAVLLPK;NDEELNK;NDEELNKLLGK;VTIAQGGVLPNIQAVLLPK;VTIAQGGVLPNIQAVLLPKK 8 41.5 0 89.171 12.261 18.0543 18.1194 10.7884 13.3588 7.44964 10.9548 16.9523 16.9418 16.3628 11.4024 13.6788 Q6FI81 CPIN1_HUMAN Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) CIAPIN1 CUA001 PRO0915 Homo sapiens (Human) apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066] cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]" VLLSDSNLHDA 1 3.5 0.013972 0.8144 0 10.5605 10.6382 0 0 0 10.4275 10.9968 10.5057 8.54844 0 0 Q6FIF0 ZFAN6_HUMAN AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) ZFAND6 AWP1 ZA20D3 HT032 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; protein targeting to peroxisome [GO:0006625]; protein transport [GO:0015031]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytosol [GO:0005829] DNA binding [GO:0003677]; polyubiquitin modification-dependent protein binding [GO:0031593]; zinc ion binding [GO:0008270] VGLTGFECR 1 4.3 0.93387 -0.50444 0 0 0 0 0 9.99633 0 0 0 0 0 0 Q6GMR7 FAAH2_HUMAN Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2) FAAH2 AMDD Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; lipid catabolic process [GO:0016042] lipid droplet [GO:0005811]; membrane [GO:0016020] fatty acid amide hydrolase activity [GO:0017064] MAPSFTARIQLFLLR 1 2.8 0.95294 -0.67666 0 0 0 8.71959 0 8.44286 0 0 0 0 0 0 Q6GPH4 XAF1_HUMAN XIAP-associated factor 1 (BIRC4-binding protein) XAF1 BIRC4BP XIAPAF1 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; response to interferon-beta [GO:0035456] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] molecular sequestering activity [GO:0140313]; zinc ion binding [GO:0008270] CCPDSEFK;ETMEEHCK;GKSTVIIATK;MEGDFSVCRNCK 4 12.6 0.97926 -1.8998 0 0 0 0 7.16993 0 0 0 0 11.1767 4.65575 5.95643 Q6GPH6 IPIL1_HUMAN "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1" ITPRIPL1 KIAA1754L Homo sapiens (Human) negative regulation of T cell receptor signaling pathway [GO:0050860] membrane [GO:0016020]; plasma membrane [GO:0005886] receptor ligand activity [GO:0048018] SLHHFLIGNNFLPLTIPIPK;TVQWFRNMMGNAWALVAHK 2 7 0.89771 -0.25426 0 0 0 0 0 5.99472 11.0072 0 0 0 0 0 Q6GYQ0 RGPA1_HUMAN Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] ATAINASRALK;ATMLTDKYKQGK;ELRNLDSR;ETVPTWDTIR;GVGHEFQK;HFNDLNMK;LLHTGNSLKIR;MPSQAFLQFQGK;REGVRLFLLWLQALQNNCSK;SLEWKNK;SNVNFVTEIFR;TVLSSAR;VLDTKKDALTR 13 6.7 0.97805 -6.3199 8.77403 14.5473 15.0166 11.5411 11.5132 0 7.09212 0 10.7 15.5346 0 11.934 Q6H8Q1 ABLM2_HUMAN Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) ABLIM2 KIAA1808 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] DLAALPK;LALWKRNDLK;VLEAGEK;VQDKYFHIK 4 5.4 0.96332 -1.0987 0 11.6222 8.14155 0 0 0 13.6559 0 13.5364 0 0 8.99678 Q6H8Q1 ABLM2_HUMAN Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) ABLIM2 KIAA1808 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] DLAALPK;LALWKRNDLK;SPQHYSRPDTGVKDNIYR 3 10.1 0.82579 -0.020262 0 10.7445 0 0 0 0 0 0 0 0 0 0 Q6H9L7 ISM2_HUMAN Isthmin-2 (Thrombospondin and AMOP domain-containing isthmin-like protein 1) (Thrombospondin type-1 domain-containing protein 3) ISM2 TAIL1 THSD3 PSEC0137 Homo sapiens (Human) extracellular region [GO:0005576] TPWASPVR 1 2.7 0.91442 -0.39033 0 0 0 0 0 0 9.58045 0 0 0 0 0 Q6HA08 ASTL_HUMAN Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) ASTL Homo sapiens (Human) cell adhesion [GO:0007155]; fertilization [GO:0009566]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of protein processing [GO:0010954]; prevention of polyspermy [GO:0060468]; proteolysis [GO:0006508] cortical granule [GO:0060473]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] aspartic-type peptidase activity [GO:0070001]; glutamic-type peptidase activity [GO:0070002]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] QVILEALAEFER;WNLSASDITR 2 5.1 0.93374 -0.49952 0 0 0 0 0 7.8805 0 7.73064 0 0 0 0 Q6I9Y2 THOC7_HUMAN THO complex subunit 7 (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) THOC7 NIF3L1BP1 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] RNA binding [GO:0003723] ELEALGK;IAECKKQILQAK;VIQHHPDR 3 13.2 0.91655 -0.4164 0 0 11.6423 0 0 0 8.65091 0 0 0 0 11.4296 Q6IA17 SIGIR_HUMAN Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) SIGIRR UNQ301/PRO342 Homo sapiens (Human) acute-phase response [GO:0006953]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of Toll signaling pathway [GO:0045751] cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886] LYDAYVSYSDCPEDR 1 3.7 0.64617 0.17145 0 0 0 6.72751 0 6.19663 0 0 0 0 0 0 Q6IA69 NADE_HUMAN Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) NADSYN1 Homo sapiens (Human) 'de novo' NAD biosynthetic process [GO:0034627]; NAD biosynthetic process [GO:0009435] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952] ILTTCYMASK;NSSQETCTR;TIVNQISYTPQDPRDLCGR;VIFLNRKILLIRPK 4 7.4 0.95196 -0.70973 0 0 0 9.7658 0 8.40497 0 0 0 0 0 5.84687 Q6IA86 ELP2_HUMAN Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) ELP2 STATIP1 Homo sapiens (Human) regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] protein kinase binding [GO:0019901] AWKPPASLALCSR;CLAMINR;ENTFTIENESVK;ICLYTWK;LKENTFTIENESVK;VNCIQWICK 6 6.1 0.97851 -2.1193 8.96743 0 0 0 0 0 8.03447 9.94256 9.02569 0 0 12.5973 Q6IAA8 LTOR1_HUMAN Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) LAMTOR1 C11orf59 PDRO PP7157 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; cholesterol homeostasis [GO:0042632]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104]; protein localization to membrane [GO:0072657]; regulation of cell growth [GO:0001558]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol import [GO:0060620]; regulation of receptor recycling [GO:0001919]; TORC1 signaling [GO:0038202] azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; Ragulator complex [GO:0071986]; specific granule membrane [GO:0035579] GTPase binding [GO:0051020]; protein-membrane adaptor activity [GO:0043495] GCCYSSENEDSDQDR;GCCYSSENEDSDQDREER;GCCYSSENEDSDQDREERK;MGCCYSSENEDSDQDR;MGCCYSSENEDSDQDREER 5 12.4 0.88245 -0.17523 6.74079 0 0 5.66835 0 0 0 10.6698 7.3856 5.55915 0 4.75366 Q6IAN0 DRS7B_HUMAN Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1) DHRS7B SDR32C1 CGI-93 UNQ212/PRO238 Homo sapiens (Human) adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; ether lipid biosynthetic process [GO:0008611]; inflammatory response [GO:0006954]; neutrophil differentiation [GO:0030223]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of cold-induced thermogenesis [GO:0120161] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; transcription regulator complex [GO:0005667] acylglycerone-phosphate reductase (NADP+) activity [GO:0000140]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714] NGGALEELIR 1 3.1 0.9286 -0.46373 0 0 0 0 0 9.7139 0 0 0 0 0 0 Q6IB77 GLYAT_HUMAN Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (HRP-1(CLP)) GLYAT ACGNAT CAT GAT Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; benzoyl-CoA metabolic process [GO:1901787]; glycine metabolic process [GO:0006544]; monocarboxylic acid metabolic process [GO:0032787]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyltransferase activity [GO:0016746]; glycine N-acyltransferase activity [GO:0047961]; glycine N-benzoyltransferase activity [GO:0047962] SLPASLKVYGTVFHINHGNPFNLK 1 8.1 0.83583 -0.034544 0 0 0 0 0 10.1196 0 0 0 0 0 0 Q6IBS0 TWF2_HUMAN Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) TWF2 PTK9L MSTP011 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; cell projection organization [GO:0030030]; cellular response to growth factor stimulus [GO:0071363]; cellular response to retinoic acid [GO:0071300]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of axon extension [GO:0045773]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of lamellipodium assembly [GO:0010591]; regulation of microvillus length [GO:0032532]; sequestering of actin monomers [GO:0042989] actin filament [GO:0005884]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420] "actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]" DAARYHFFLYK;GPGENGDDS 2 5.7 0.93378 -0.50492 0 0 0 0 0 0 3.95038 0 0 0 10.2823 0 Q6IBW4 CNDH2_HUMAN Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) NCAPH2 CAPH2 Homo sapiens (Human) female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid separation [GO:0051306]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; T cell differentiation in thymus [GO:0033077] cell junction [GO:0030054]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] FVQETELSQR;LQDFHQWYLAAYADHADSR 2 4.8 0.88955 -0.20659 8.97467 8.4515 0 0 0 0 9.19756 0 0 0 0 0 Q6IC98 GRAM4_HUMAN GRAM domain-containing protein 4 (Death-inducing protein) GRAMD4 DIP KIAA0767 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; positive regulation of cysteine-type endopeptidase activity [GO:2001056] endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] DPAGPGTLIMATGVQDFNR;FFLIDFIFKRCPR;LSLNYLIARGWR;LTENMRR;QELDRER;SQGLSSRLQKWFYER 6 12.6 0.97271 -2.7404 0 12.0907 0 0 10.0095 0 9.29705 0 11.5997 0 0 0 Q6ICG6 K0930_HUMAN Uncharacterized protein KIAA0930 KIAA0930 C22orf9 Homo sapiens (Human) KSQQVFASPSK 1 2.7 0.91094 -0.32034 0 0 0 0 0 0 0 0 12.0381 0 0 0 Q6ICG8 WBP2L_HUMAN Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like) WBP2NL PAWP Homo sapiens (Human) egg activation [GO:0007343]; male pronucleus assembly [GO:0035039]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634]; perinuclear theca [GO:0033011]; sperm flagellum [GO:0036126]; sperm head [GO:0061827] chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]; WW domain binding [GO:0050699] GALIPNGESLLK 1 3.9 0.89629 -0.23651 11.626 0 0 0 0 0 0 0 0 0 0 0 Q6ICH7 ASPH2_HUMAN Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-) ASPHD2 Homo sapiens (Human) membrane [GO:0016020] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] NFQTILCEFETLYK 1 3.8 0.68244 0.16503 0 0 0 0 0 0 0 0 0 6.79559 0 0 Q6ICL7 S35E4_HUMAN Solute carrier family 35 member E4 SLC35E4 Homo sapiens (Human) transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297] SAGQGQE 1 3 0.71104 0.15645 0 0 0 7.90935 8.14124 7.75455 8.42282 7.85866 0 7.74779 0 0 Q6IE81 JADE1_HUMAN Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) JADE1 KIAA1807 PHF17 Homo sapiens (Human) apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] AATSPGVGQSAPGTRK;KQKLQQLEDEFYTFVNLLDVAR;LISAQQK;NLTYMVTR;TLADSVCR 5 7.2 0.98049 -1.6717 0 0 0 0 9.69375 9.2086 10.0681 10.6539 11.0294 9.55292 0 0 Q6IEE7 T132E_HUMAN Transmembrane protein 132E TMEM132E Homo sapiens (Human) posterior lateral line neuromast hair cell development [GO:0035677] cell body [GO:0044297]; membrane [GO:0016020] ESEDEDEEEEER 1 1.1 0.89598 -0.24234 0 0 4.49115 0 0 0 0 0 0 0 0 0 Q6IEE8 SN12L_HUMAN Schlafen family member 12-like SLFN12L SLFN5 Homo sapiens (Human) membrane [GO:0016020] DYSTQTAQTLK;IGGYTKKVCVMTK;MAMKIMEK 3 5.2 0.98096 -1.6969 0 0 0 0 0 7.39883 0 0 0 11.3862 0 0 Q6IEG0 SNR48_HUMAN U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) (U11/U12-48K) SNRNP48 C6orf151 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] metal ion binding [GO:0046872] AEDDAEK;LALYDFVVEETK 2 5.6 0.95524 -0.86296 0 0 0 0 0 0 11.096 0 0 0 0 0 Q6IFG1 O52E8_HUMAN Olfactory receptor 52E8 (Olfactory receptor OR11-54) OR52E8 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILYAVFCLPSWEAR;VNIRFGLGNISLLLLDVILIILSYVR 2 12.8 0.82952 -0.022695 0 0 10.4532 0 0 0 0 8.54141 0 0 0 0 Q6IFH4 OR6B2_HUMAN Olfactory receptor 6B2 (Olfactory receptor OR2-1) OR6B2 OR6B2P Homo sapiens (Human) cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] SGENVTK 1 2.2 0.92871 -0.4716 0 0 0 0 0 0 0 9.47847 10.5595 0 0 0 Q6IFN5 O7E24_HUMAN Olfactory receptor 7E24 (Olfactory receptor OR19-14) OR7E24 OR7E24P Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FVAICHPLHYRIIMNPR 1 5 0.91775 -0.43524 0 0 0 0 0 0 0 0 0 0 0 6.53229 Q6IMI4 ST6B1_HUMAN Sulfotransferase 6B1 (ST6B1) (Thyroxine sulfotransferase) (EC 2.8.2.n2) SULT6B1 Homo sapiens (Human) sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829] sulfotransferase activity [GO:0008146] YPEFPVLECGDSEKYQR 1 5.6 0.91839 -0.43557 0 0 0 0 0 0 0 0 0 6.41814 0 0 Q6IMN6 CAPR2_HUMAN Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) cell differentiation [GO:0030154]; dorsal/ventral axis specification [GO:0009950]; negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] EVQVSQASLGFELTSVEK;VAFSAAR;YEEVLHNLEFAKELQK 3 3.6 0.96117 -1.0623 0 0 0 7.99288 7.71706 0 0 0 0 7.46972 0 0 Q6IMN6 CAPR2_HUMAN Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) cell differentiation [GO:0030154]; dorsal/ventral axis specification [GO:0009950]; negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] EVQVSQASLGFELTSVEK;NSLLLIKQQGGVILLR;YEEVLHNLEFAKELQK 3 5.5 0.8126 -0.013541 0 0 0 0 0 0 0 0 0 0 0 9.68848 Q6IN84 MRM1_HUMAN "rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)" MRM1 Homo sapiens (Human) rRNA 2'-O-methylation [GO:0000451]; rRNA modification [GO:0000154]; rRNA processing [GO:0006364] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039] DIPVLRPR 1 2.3 0.91502 -0.39033 0 0 0 0 0 0 0 0 0 0 4.16132 0 Q6IN85 P4R3A_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) PPP4R3A KIAA2010 PP4R3A SMEK1 MSTP033 Homo sapiens (Human) DNA damage response [GO:0006974]; regulation of double-strand break repair [GO:2000779] centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] LDSMRSILRNHR;LEEIAELVASSLPSPLRR;VYTLNEDRQWDDR 3 5.2 0.96492 -1.2363 0 7.97562 0 0 0 0 11.1124 0 0 2.8013 0 0 Q6IPM2 IQCE_HUMAN IQ domain-containing protein E IQCE KIAA1023 Homo sapiens (Human) limb morphogenesis [GO:0035108] ciliary membrane [GO:0060170]; cilium [GO:0005929] EGEEERRER;LSVMESSK 2 2.4 0.91573 -0.33443 0 0 0 10.5614 0 0 0 0 0 0 0 7.28827 Q6IPR1 ETFR1_HUMAN Electron transfer flavoprotein regulatory factor 1 (LYR motif-containing protein 5) ETFRF1 LYRM5 Homo sapiens (Human) respiratory electron transport chain [GO:0022904] mitochondrion [GO:0005739] NLLYLGRDYPKGADYFK 1 18.9 0.95517 -0.96911 0 0 0 0 0 0 0 0 0 0 9.56289 0 Q6IPR3 TYW3_HUMAN tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) TYW3 C1orf171 Homo sapiens (Human) tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] cytoplasm [GO:0005737] tRNA methyltransferase activity [GO:0008175] DDVIVALKKANGDATLK;NPEKTRAQCITK 2 11.2 0.95922 -1.0381 0 0 0 0 7.70674 0 10.6228 0 0 0 0 0 Q6IPT4 NB5R5_HUMAN NADH-cytochrome b5 reductase-like (EC 1.6.2.2) CYB5RL Homo sapiens (Human) bicarbonate transport [GO:0015701] endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]" ELVSCCRR 1 2.5 0.7983 0.014714 4.95699 0 0 0 0 0 0 0 0 0 0 0 Q6IQ19 CCSAP_HUMAN "Centriole, cilia and spindle-associated protein" CCSAP C1orf96 CSAP Homo sapiens (Human) cell division [GO:0051301]; mitotic spindle microtubule depolymerization [GO:1990755]; regulation of embryonic development [GO:0045995]; regulation of mitotic spindle assembly [GO:1901673] axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; spindle [GO:0005819] microtubule binding [GO:0008017] DVEDKPEQQTRTR;QTDTGSQKTHNVCASAPVHEIHESALR 2 14.8 0.93239 -0.49188 5.91896 0 0 0 0 0 0 0 0 6.848 0 0 Q6IQ21 ZN770_HUMAN Zinc finger protein 770 ZNF770 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CSICQRHFK;ENIRTRHK 2 2.5 0.97273 -2.8422 0 0 0 0 0 0 0 11.4739 0 0 0 0 Q6IQ23 PKHA7_HUMAN Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) PLEKHA7 Homo sapiens (Human) cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell-cell adhesion [GO:0090136]; pore complex assembly [GO:0046931]; zonula adherens maintenance [GO:0045218] cell junction [GO:0030054]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; pore complex [GO:0046930]; zonula adherens [GO:0005915] delta-catenin binding [GO:0070097] DLEYLDLKMTGR;LSIFCEQDR;RDMEKVER;RSVDISLGDSPR;STRHPSGGSSPPPR;VGPGHTR;VLQDLEDK 7 6.2 0.97488 -3.0886 0 0 7.28114 0 0 10.0747 11.0296 5.5235 4.16253 6.2011 0 12.539 Q6IQ26 DEN5A_HUMAN DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) DENND5A KIAA1091 RAB6IP1 Homo sapiens (Human) "negative regulation of neuron projection development [GO:0010977]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EKYIQEARTMGSTIR;FVEGLLKECR;HFHKPEK;LLSRHLKQLLSDHELTK;NEITGHTYKFPCGRWLGK;SPRLFKNVFIWDFLEK 6 6.4 0.89885 -0.23379 0 10.4858 0 0 9.73356 7.70584 13.8959 14.4424 0 0 0 10.1127 Q6IQ32 ADNP2_HUMAN Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) ADNP2 KIAA0863 ZNF508 Homo sapiens (Human) nervous system development [GO:0007399]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DEALQILALDPK;DYFHKKPYPSKK;GILVDIGLDSCKELLK;KEIELLSSLFWVWK;KPYPSKKEIELLSSLFWVWK;NHKPSVLLGFDMSELK;VLTSFKNHLHR;YFHNTSWGDVSLWEPSGK 8 8.7 0.95278 -0.7636 7.61117 0 9.77577 0 11.0337 0 12.8563 0 0 8.61504 8.92618 9.2723 Q6IQ49 SDE2_HUMAN Splicing regulator SDE2 (Replication stress response regulator SDE2) SDE2 C1orf55 Homo sapiens (Human) "cell division [GO:0051301]; cellular response to UV [GO:0034644]; DNA replication [GO:0006260]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA cis splicing, via spliceosome [GO:0045292]; protein processing [GO:0016485]; protein ubiquitination [GO:0016567]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] damaged DNA binding [GO:0003684]; snoRNA binding [GO:0030515] ALGAQIEKTTNR;GPGFGCK 2 4.2 0.96575 -1.2585 0 0 0 0 0 8.95332 0 0 0 0 0 0 Q6IS14 IF5AL_HUMAN Eukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like) EIF5AL1 Homo sapiens (Human) positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] IVEMSASKTGKHGHAK;NGFVVLK 2 14.9 0.95511 -0.97688 0 0 0 0 0 0 0 0 0 0 11.0426 0 Q6IS24 GLT17_HUMAN Polypeptide N-acetylgalactosaminyltransferase 17 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 3) (GalNAc-T-like protein 3) (pp-GaNTase-like protein 3) (Protein-UDP acetylgalactosaminyltransferase-like protein 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3) (Williams-Beuren syndrome chromosomal region 17 protein) GALNT17 WBSCR17 Homo sapiens (Human) protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] CLVDNSKSRLPQLLDCDK;CRPIAVRSGDAFHEIRPR;VKVLLVLNLIAVAGFVLFLAK;VLLVLNLIAVAGFVLFLAK 4 9.5 0.97758 -1.5213 0 0 0 8.87326 10.6642 0 0 0 0 10.3356 4.94977 5.23224 Q6ISB3 GRHL2_HUMAN Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) GRHL2 BOM TFCP2L3 Homo sapiens (Human) anterior neural tube closure [GO:0061713]; bicellular tight junction assembly [GO:0070830]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell junction assembly [GO:0034329]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; epithelial cell morphogenesis [GO:0003382]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; epithelium migration [GO:0090132]; face development [GO:0060324]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; lung lobe morphogenesis [GO:0060463]; multicellular organism growth [GO:0035264]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cell-cell junction [GO:0005911]; chromatin [GO:0000785]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" KSDITYFK;LVALVPMPSDPPFNTR 2 3.8 0.95879 -1.0347 0 0 0 0 0 0 0 0 0 0 11.5164 0 Q6IV72 ZN425_HUMAN Zinc finger protein 425 ZNF425 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" NAMRAHQR;YPKYKNSSR 2 2.3 0.98096 -1.7581 0 8.42215 0 0 0 0 0 0 0 0 13.7868 0 Q6IWH7 ANO7_HUMAN Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G) ANO7 NGEP PCANAP5 TMEM16G Homo sapiens (Human) calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] AFRDDDGHYSQTYWNLLAIR;AQEEDSTVLIDVSPPEAEKR;IDFVLVWEEDLK;LFDHGGTVFFSLFMALWAVLLLEYWKRK 4 9.1 0.045694 0.49548 0 0 0 8.97378 0 7.77959 7.72581 6.14051 0 0 0 0 Q6J4K2 NCLX_HUMAN "Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)" SLC8B1 NCKX6 NCLX SLC24A6 Homo sapiens (Human) calcium export from the mitochondrion [GO:0099093]; glucose homeostasis [GO:0042593]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; monoatomic ion transport [GO:0006811]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; regulation of lymphocyte chemotaxis [GO:1901623]; regulation of store-operated calcium entry [GO:2001256] membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:sodium antiporter activity [GO:0005432]; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086038]; protein homodimerization activity [GO:0042803] KVCGLNVSDRCDFIR;VTLAWALGYLGLYVFYVVTVILCTWIYQRQR 2 7.9 0.93617 -0.53432 0 0 0 0 0 0 9.06026 0 4.37274 0 0 0 Q6JQN1 ACD10_HUMAN Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) ACAD10 Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] ARWLIPLLEGK;ELEALLGFTLRVGVPNTRPVKK;ENMVLGPGRGFEIAQGRLGPGR 3 5.2 0.96701 -1.2803 0 0 7.68433 9.21914 0 7.84122 0 0 0 7.35447 0 0 Q6JVE6 LCN10_HUMAN Epididymal-specific lipocalin-10 LCN10 Homo sapiens (Human) extracellular region [GO:0005576] small molecule binding [GO:0036094] KLGASVVKVNK;VGQLRVLLAFR 2 11 0.97494 -3.1346 8.74008 0 0 0 8.57527 0 0 0 0 0 0 0 Q6K0P9 IFIX_HUMAN Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X) PYHIN1 IFIX Homo sapiens (Human) "activation of innate immune response [GO:0002218]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]" cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] double-stranded DNA binding [GO:0003690]; ubiquitin protein ligase binding [GO:0031625] GECHNIPCEKGDK;IESIPVKGIIPSK 2 5.3 0.95493 -0.89951 0 0 0 6.81083 0 0 0 0 0 0 7.51538 0 Q6KB66 K2C80_HUMAN "Keratin, type II cytoskeletal 80 (Cytokeratin-80) (CK-80) (Keratin-80) (K80) (Type-II keratin Kb20)" KRT80 KB20 Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] DLDAECLHRTELETK;QLRKYQELMNVK;YEDEISKR 3 7.7 0.95462 -0.95773 0 0 0 0 0 0 0 10.6778 4.22836 0 9.35546 0 Q6KC79 NIPBL_HUMAN Nipped-B-like protein (Delangin) (SCC2 homolog) NIPBL IDN3 SCC2 Homo sapiens (Human) brain development [GO:0007420]; cellular response to X-ray [GO:0071481]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; DNA damage response [GO:0006974]; ear morphogenesis [GO:0042471]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of mitotic sister chromatid cohesion [GO:0034087]; establishment of protein localization to chromatin [GO:0071169]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; gallbladder development [GO:0061010]; heart morphogenesis [GO:0003007]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; metanephros development [GO:0001656]; mitotic cohesin loading [GO:0061780]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron migration [GO:2001224]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of developmental growth [GO:0048638]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sensory perception of sound [GO:0007605]; somatic stem cell population maintenance [GO:0035019]; uterus morphogenesis [GO:0061038] chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; promoter-specific chromatin binding [GO:1990841]; transcription corepressor activity [GO:0003714] DGNVTQETKKMEMK;DICIEQPTFPK;DKVLELLMYFTK;FHLQNTLYPQYDPVYRLDPHGGGLLSSK;HESGDSR;ILKQVSGGEDEIQQLQK;KHRHESGDSR;LDPHGGGLLSSKAK;LSLDDVQK;LSTDKTVK;MIRRVNDEEGIK;NEGRPETPKHR;NNTAAETEDDESDGEDR;RSIVKQYLDFK;SDPELSKSEMKQSESR;STPENHPETPKKK;TGVHFHPK;YSPSESAKVYDK 18 7.5 0.97606 -4.5018 0 14.0406 11.5547 13.5432 9.80634 0 11.5974 0 10.6526 10.2207 13.5812 11.906 Q6L8H2 KRA53_HUMAN Keratin-associated protein 5-3 (Keratin-associated protein 5-9) (Keratin-associated protein 5.3) (Keratin-associated protein 5.9) (UHS KerB-like) (Ultrahigh sulfur keratin-associated protein 5.3) KRTAP5-3 KAP5-9 KAP5.3 KRTAP5-9 KRTAP5.3 KRTAP5.9 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] GVCGSCGGCKGGCGSCGGSK 1 8.4 0.81744 -0.01737 0 0 0 6.57016 0 0 0 0 0 0 6.67044 0 Q6L8H4 KRA51_HUMAN "Keratin-associated protein 5-1 (Keratin, cuticle, ultrahigh sulphur 1-like) (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1)" KRTAP5-1 KAP5.1 KRN1L KRTAP5.1 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] GACGSCGGSKGGCGSCGGCK;GACGSCGGSKGGCGSCGGCKGGCGSCGGSK 2 10.8 0.71278 0.14545 0 0 0 0 0 9.86748 0 0 0 0 7.1638 0 Q6L8Q7 PDE12_HUMAN "2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)" PDE12 Homo sapiens (Human) "antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; defense response to virus [GO:0051607]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid metabolic process [GO:0090304]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; oligoribonucleotidase activity [GO:0034611]; poly(A)-specific ribonuclease activity [GO:0004535] DQSEPLGR;LSLSFALADGSHK;LVLYPSAQEK;QHEGLATFYR 4 6.7 0.96409 -1.1797 0 0 0 8.67811 0 0 0 0 0 0 11.2 0 Q6L9W6 B4GN3_HUMAN "Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GalNAcT3) (Beta4GalNAc-T3) (Beta4GalNAcT3) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase III) (N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2) (NGalNAc-T2)" B4GALNT3 Homo sapiens (Human) Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231] acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842] AARPPLLLRPVKLLR;AARPPLLLRPVKLLRR;ILQAGLDVER 3 2.6 0.95238 -0.75937 0 0 0 3.7419 0 0 3.38433 0 5.16748 3.4547 0 4.97053 Q6MZM0 HPHL1_HUMAN Ferroxidase HEPHL1 (EC 1.16.3.1) (Hephaestin-like protein 1) HEPHL1 Homo sapiens (Human) copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] plasma membrane [GO:0005886] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322] AALVILFIIGLLLLITTVILSLR 1 2 0.70262 0.16126 0 0 0 4.95592 0 0 4.32423 0 0 0 0 0 Q6MZP7 LIN54_HUMAN Protein lin-54 homolog (CXC domain-containing protein 1) LIN54 CXCDC1 KIAA2037 Homo sapiens (Human) nucleosome organization [GO:0034728]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] metal ion binding [GO:0046872]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; transcription regulatory region nucleic acid binding [GO:0001067] LIFAKPINSK;NYCECYEAKIMCSSICKCIGCK;SPNKAVK 3 5.2 0.98036 -1.5553 0 0 0 0 0 0 0 0 0 0 8.58924 0 Q6MZQ0 PRR5L_HUMAN Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) PRR5L PROTOR2 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of fibroblast migration [GO:0010762]; TORC2 signaling [GO:0038203] TORC2 complex [GO:0031932] ubiquitin protein ligase binding [GO:0031625] QISLLGFRDLVLLKVK;SFSGPTYTLARR 2 7.6 0.74589 0.088031 0 0 0 0 4.52275 0 0 0 8.63401 0 0 0 Q6MZT1 R7BP_HUMAN Regulator of G-protein signaling 7-binding protein (R7 family-binding protein) RGS7BP R7BP Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of postsynaptic membrane potential [GO:0060078] axon [GO:0030424]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] EPGGGTKSLDCK 1 4.7 0.88732 -0.18597 0 0 0 0 0 8.61927 0 0 0 0 0 0 Q6MZW2 FSTL4_HUMAN Follistatin-related protein 4 (Follistatin-like protein 4) FSTL4 KIAA1061 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031549]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; regulation of BMP signaling pathway [GO:0030510] extracellular region [GO:0005576]; secretory granule [GO:0030141] brain-derived neurotrophic factor binding [GO:0048403]; calcium ion binding [GO:0005509] DSGLFGQYLLTPAR 1 1.7 0.9143 -0.33743 0 0 0 0 0 0 0 0 0 0 0 14.1513 Q6MZZ7 CAN13_HUMAN Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13) CAPN13 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] AIENTDFLR;FPPVFFSSFR;YSDSVGR 3 3.9 0.96489 -1.1516 11.334 0 0 0 7.99288 9.93174 0 0 11.1405 0 0 0 Q6N021 TET2_HUMAN Methylcytosine dioxygenase TET2 (EC 1.14.11.80) TET2 KIAA1546 Nbla00191 Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; leukocyte differentiation [GO:0002521]; myeloid cell differentiation [GO:0030099]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; response to organic cyclic compound [GO:0014070]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270] LLDTPIKNLLDTPVK;LLGDDPK;QAYTQKTTQLEHK;RNSPYSQTMK;VTGPYNR;YGPDYVPQKSHGK 6 3.2 0.9787 -2.1152 10.0449 0 0 0 0 2.69075 8.77327 0 8.49665 0 8.99367 0 Q6N021 TET2_HUMAN Methylcytosine dioxygenase TET2 (EC 1.14.11.80) TET2 KIAA1546 Nbla00191 Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; leukocyte differentiation [GO:0002521]; myeloid cell differentiation [GO:0030099]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; response to organic cyclic compound [GO:0014070]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270] LLDTPIKNLLDTPVK;QAYTQKTTQLEHK;RNSPYSQTMK;TQYDFPSCRCVGKCQK 4 4.6 0.44802 0.19195 0 0 4.12805 0 0 0 0 0 0 0 0 0 Q6N022 TEN4_HUMAN Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) TENM4 KIAA1302 ODZ4 TNM4 Homo sapiens (Human) cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AVRQAWAREQQR;DFRHSHSPAHK;EGCPGLCNGNGR;IPPGTFWRSQVFIDHPVHLK;KWFAAAPDLSYYFIWDK;LGGWSLDK;RVIYKYGK;VIYKYGK 8 3.2 0.96709 -1.2802 8.28919 0 0 0 0 8.31188 0 0 0 8.15492 0 12.2462 Q6N043 Z280D_HUMAN Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) ZNF280D KIAA1584 SUHW4 ZNF634 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSSKNIKDLR;HHLELEKQSSESWENHTTCQHCYR;QIQHVCQEMELK;QSTLASSNKK 4 5.7 0.9639 -1.1857 8.47614 0 0 0 0 6.96243 0 0 10.7273 11.6858 11.2391 11.1836 Q6N063 OGFD2_HUMAN 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) OGFOD2 Homo sapiens (Human) "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FLQPLMALLYPDCGGGR;VELEQEVER 2 9 0.91683 -0.41142 0 0 0 0 8.68212 0 0 0 10.5735 0 0 0 Q6N069 NAA16_HUMAN "N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)" NAA16 NARG1L NAT2 Homo sapiens (Human) N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] acetyltransferase activator activity [GO:0010698]; ribosome binding [GO:0043022] GLTLNCLGKKEEAYEFVR;YDEAIKCYRNALK 2 3.6 0.44783 0.19219 0 0 0 0 7.38491 0 0 0 0 0 0 0 Q6N075 MFSD5_HUMAN Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) molybdate ion transport [GO:0015689]; monoatomic ion transport [GO:0006811] membrane [GO:0016020]; plasma membrane [GO:0005886] molybdate ion transmembrane transporter activity [GO:0015098] AFSRTCAGGLR;VIPETEQAGVLNWFR 2 5.8 0.97334 -1.4174 0 9.41026 0 0 0 0 0 0 0 0 0 0 Q6NS38 ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1) ALKBH2 ABH2 Homo sapiens (Human) DNA alkylation repair [GO:0006307] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] broad specificity oxidative DNA demethylase activity [GO:0035516]; cytosine C-5 DNA demethylase activity [GO:0051747]; ferrous iron binding [GO:0008198]; rDNA binding [GO:0000182] VNLTFRKILLTK 1 4.6 0.86932 -0.096772 0 0 0 0 0 0 0 0 0 4.20445 0 0 Q6NSI1 AR26L_HUMAN Putative ankyrin repeat domain-containing protein 26-like protein ANKRD26P1 Homo sapiens (Human) KLLLHHANIESANK 1 4.4 0.58685 0.17937 0 0 0 0 0 0 0 0 0 0 7.94755 7.29939 Q6NSI4 RADX_HUMAN "RPA-related protein RADX (RPA-related and RAD51-antagonist, X-chromosome)" RADX CXorf57 Homo sapiens (Human) negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282] nuclear speck [GO:0016607]; replication fork [GO:0005657] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] EIEDLQYREQK;FMFEHRKFLSDQYNSQPAK;ISRVSCLYNEKR;RNFPALLVRILHK;VGLVLLLQDYSVK 5 8 0.9795 -1.5403 0 6.44725 0 9.89363 0 0 0 0 0 11.007 5.68894 0 Q6NSI4 RADX_HUMAN "RPA-related protein RADX (RPA-related and RAD51-antagonist, X-chromosome)" RADX CXorf57 Homo sapiens (Human) negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282] nuclear speck [GO:0016607]; replication fork [GO:0005657] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] ISRVSCLYNEKR;RNFPALLVRILHK;VGLVLLLQDYSVK;YVYILYVWLMLFQLVIFILFFYGSDLKFSNIHR 4 12.5 0.83352 -0.027267 7.08481 6.10861 0 0 0 0 7.70943 0 0 0 0 0 Q6NSI8 SANBR_HUMAN SANT and BTB domain regulator of class switch recombination (SANT and BTB domain regulator of CSR) SANBR KIAA1841 Homo sapiens (Human) isotype switching [GO:0045190] identical protein binding [GO:0042802] ALEKSASRDVSPFVMSMQK;FNQDAQREDDQR;INVDRRGNIVYIHIR;LLTKETERR;SASRDVSPFVMSMQK 5 7.7 0.97523 -3.3056 0 0 0 0 0 0 0 0 0 9.75569 10.5738 9.05498 Q6NSJ0 MYORG_HUMAN Myogenesis-regulating glycosidase (EC 3.2.1.-) (Uncharacterized family 31 glucosidase KIAA1161) MYORG KIAA1161 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" AELLDLKAGGFSIR;AGGFSIR;FGEGVER 3 2.9 0.96541 -1.2147 0 0 0 0 0 0 0 0 0 10.1245 10.926 0 Q6NSJ2 PHLB3_HUMAN Pleckstrin homology-like domain family B member 3 PHLDB3 Homo sapiens (Human) enzyme binding [GO:0019899] ELQRQRK;LTFCVKTYER 2 2.7 0.97473 -1.4368 0 0 0 0 0 0 0 0 0 0 0 9.73941 Q6NSJ2 PHLB3_HUMAN Pleckstrin homology-like domain family B member 3 PHLDB3 Homo sapiens (Human) enzyme binding [GO:0019899] ELQRQRK;VQELQASMAQHRVSHA 2 8.2 0.91593 -0.43363 0 0 0 0 0 0 0 10.144 0 0 0 0 Q6NSJ5 LRC8E_HUMAN Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) LRRC8E Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] EGEQAKALFEK;EVPLWVFGLR;GLEELHLEGLFPQELAR;ISFLVACR;VLAEPEK 5 6.7 0.9733 -2.938 10.9462 10.3844 0 0 0 0 11.7148 0 12.7083 0 10.371 0 Q6NSX1 CCD70_HUMAN Coiled-coil domain-containing protein 70 CCDC70 Homo sapiens (Human) plasma membrane [GO:0005886] AFREEMK;ALWEEEKALWVEER;TFWKEDK;TFWKEDKAFWK;TFWKEEK 5 17.6 0.97618 -4.4902 0 0 0 0 0 0 0 0 0 6.1697 0 11.5269 Q6NSZ9 ZSC25_HUMAN Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) ZSCAN25 ZNF498 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELQELCRR;LEKELPWGR;SFNQRSILNR;THSSFWKPFQCPECGK 4 7.9 0.97953 -1.8788 0 0 6.96463 0 8.0354 0 11.1273 0 0 0 9.30113 0 Q6NT04 TIGD7_HUMAN Tigger transposable element-derived protein 7 TIGD7 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] STFYDIKKNK 1 1.8 0.86934 -0.09132 0 5.73045 0 0 0 0 0 0 0 0 0 0 Q6NT32 EST5A_HUMAN Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) CES5A CES7 Homo sapiens (Human) extracellular region [GO:0005576] carboxylesterase activity [GO:0106435] ELLTLSQK;SFTRVVDGAFFPNEPLDLLSQK 2 5.2 0.95532 -0.96652 0 7.21247 0 0 5.91917 0 0 0 0 0 0 0 Q6NT76 HMBX1_HUMAN Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) HMBOX1 HOT1 TAH1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; telomere maintenance via telomerase [GO:0007004]; telomere-telomerase complex assembly [GO:1905324] "Cajal body [GO:0015030]; centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; telomeric DNA binding [GO:0042162] LDQEHSDKFGRR;VYNWFANRR 2 5 0.96427 -1.1725 0 0 5.42596 0 0 0 0 0 0 0 0 0 Q6NTE8 MRNIP_HUMAN MRN complex-interacting protein (MRN-interacting protein) MRNIP C5orf45 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; response to ionizing radiation [GO:0010212] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] VLRCCSCR 1 2.3 0.94146 -0.60099 0 0 0 0 0 0 0 0 0 0 0 5.91994 Q6NTE8 MRNIP_HUMAN MRN complex-interacting protein (MRN-interacting protein) MRNIP C5orf45 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; response to ionizing radiation [GO:0010212] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] ECQVDMQSLWR 1 4.1 0.80872 0.010735 0 0 0 0 0 0 0 4.7867 0 0 0 0 Q6NTF9 RHBD2_HUMAN Rhomboid domain-containing protein 2 RHBDD2 RHBDL7 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase activity [GO:0004252]; signal recognition particle binding [GO:0005047] LGVTTVR 1 3.1 0.93524 -0.52111 0 0 0 0 9.64286 0 0 0 0 0 0 0 Q6NUI1 C144L_HUMAN Putative coiled-coil domain-containing protein 144 N-terminal-like CCDC144NL Homo sapiens (Human) RGGAGGSPKPAVYATR 1 7.2 0.91333 -0.38326 0 0 0 0 0 0 0 0 0 0 0 9.13271 Q6NUI2 GPAT2_HUMAN "Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT-2) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase GPAT2) (EC 2.3.1.51) (xGPAT1)" GPAT2 Homo sapiens (Human) CDP-diacylglycerol biosynthetic process [GO:0016024]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophospholipid metabolic process [GO:0006650]; phosphatidic acid biosynthetic process [GO:0006654]; piRNA processing [GO:0034587]; triglyceride biosynthetic process [GO:0019432] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366] ACSPALR;ATMLEGRCQTQPRSSPSGR;EENTRFRGWLVR;LHLSPTFASLDNQEK;SLLQHSLSLLR 5 8.1 0.9553 -0.88048 0 0 0 0 0 0 0 0 7.77386 0 10.9805 0 Q6NUI6 CHADL_HUMAN Chondroadherin-like protein CHADL SLRR4B Homo sapiens (Human) negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of collagen fibril organization [GO:1904027] collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent conferring compression resistance [GO:0030021] MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQR 1 4.2 0.61406 0.17447 0 0 0 0 0 0 0 0 6.62426 0 0 0 Q6NUJ1 SAPL1_HUMAN Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like] PSAPL1 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665] cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]; membrane [GO:0016020] LCNAVQHCQKHVWKEMHLHAGEHA 1 4.6 0.95899 -1.0078 0 0 0 0 0 0 11.6342 0 0 0 0 0 Q6NUJ5 PWP2B_HUMAN PWWP domain-containing protein 2B PWWP2B PWWP2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cold-induced thermogenesis [GO:0120161] nucleoplasm [GO:0005654]; nucleus [GO:0005634] NuRD complex binding [GO:0120325] AITEAANAAR;LGSGPDRELR 2 3.4 0.98188 -1.5814 0 11.734 0 0 0 0 10.6287 0 0 0 0 0 Q6NUK4 REEP3_HUMAN Receptor expression-enhancing protein 3 REEP3 C10orf74 Homo sapiens (Human) cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782] microtubule binding [GO:0008017] EIDDYIVQAK;EIDDYIVQAKER;VIVHLPF 3 13 0.98037 -1.796 0 0 0 0 0 0 0 0 3.84378 0 0 0 Q6NUM6 TYW1B_HUMAN S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B) TYW1B RSAFD2 Homo sapiens (Human) wybutosine biosynthetic process [GO:0031591] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]" NEDGERRAMITPALR;SCGGHCK;SFDPKDTR 3 4.5 0.97523 -3.3699 12.6005 0 0 0 0 0 0 0 0 9.15578 0 0 Q6NUM6 TYW1B_HUMAN S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B) TYW1B RSAFD2 Homo sapiens (Human) wybutosine biosynthetic process [GO:0031591] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]" DQPEMILKEAIENHQNMIK;SFDPKDTR 2 9.2 0.91903 -0.43656 0 12.1169 0 0 0 0 0 8.88771 0 0 0 0 Q6NUM9 RETST_HUMAN "All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)" RETSAT PPSIG UNQ439/PRO872 Homo sapiens (Human) retinol metabolic process [GO:0042572] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640] "all-trans-retinol 13,14-reductase activity [GO:0051786]" MWLPLVLLLAVLLLAVLCK;WLPLVLLLAVLLLAVLCK 2 3.1 0.53888 0.18519 0 6.46734 0 0 0 0 7.46565 0 7.85611 0 0 0 Q6NUN0 ACSM5_HUMAN "Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)" ACSM5 MACS3 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872] TVSGKIQR;VILNTLSK 2 2.8 0.95836 -1.0038 0 0 11.0687 0 0 0 0 0 0 0 0 0 Q6NUN7 JHY_HUMAN Jhy protein homolog JHY C11orf63 Homo sapiens (Human) axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; regulation of establishment of planar polarity [GO:0090175] extracellular region [GO:0005576] ALEYAKTIPKPKPSNLTHQASKEQK;QVKEYNMK;VESESQLSSER;WHQRAQQLK 4 6.8 0.98065 -1.5985 0 0 0 9.79593 5.36096 0 0 0 9.60975 6.45086 0 0 Q6NUN9 ZN746_HUMAN Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) ZNF746 PARIS Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" ELYKHVMR;LIDHYRTHTGVRPFTCTVCGK;NHAAGAK 3 5.6 0.91012 -0.28031 0 0 0 0 0 7.53325 0 0 0 0 9.64265 0 Q6NUP7 PP4R4_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 4 PPP4R4 KIAA1622 PP4R4 Homo sapiens (Human) blastocyst hatching [GO:0001835] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein serine/threonine phosphatase complex [GO:0008287] protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] DKDVLAIVK;LIEQLGQGK;NASSVPSSFSPNTPLPSTSRGTGNSVDPK 3 5.4 0.95957 -1.0454 0 0 0 0 0 0 0 0 11.7961 10.2503 5.55161 0 Q6NUQ1 RINT1_HUMAN RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) RINT1 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] LIEQRTVSKMQLEEQVLTISSEIPK 1 3.2 0.66979 0.16893 0 0 0 0 0 0 0 0 0 8.16967 0 0 Q6NUQ4 TM214_HUMAN Transmembrane protein 214 TMEM214 PP446 Homo sapiens (Human) apoptotic process [GO:0006915] cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] ALDVADLQKELDK;FLELLRSHQSRPAK;SLSPFAITYLDR 3 5.7 0.95603 -0.85167 0 12.1489 0 0 0 0 4.19346 0 0 0 0 0 Q6NUS6 TECT3_HUMAN Tectonic-3 TCTN3 C10orf61 TECT3 PSEC0041 UNQ1881/PRO4324 Homo sapiens (Human) apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; positive regulation of apoptotic process [GO:0043065]; smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; nucleus [GO:0005634] VPRSMTDPQNMEVTYEIETNGTFGIQK 1 6.3 0.84064 -0.045996 0 8.54411 0 0 0 0 0 0 0 0 0 0 Q6NUS8 UD3A1_HUMAN UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17) UGT3A1 Homo sapiens (Human) UDP-N-acetylglucosamine transferase complex [GO:0043541] glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194] WFSPEDHQKRIK 1 2.3 0.86645 -0.092828 0 0 0 0 6.37016 0 0 0 0 0 0 0 Q6NUT2 D19L2_HUMAN Probable C-mannosyltransferase DPY19L2 (EC 2.4.1.-) (Dpy-19-like protein 2) (Protein dpy-19 homolog 2) DPY19L2 UNQ3127/PRO10284 Homo sapiens (Human) spermatid development [GO:0007286] nuclear inner membrane [GO:0005637]; nucleus [GO:0005634] mannosyltransferase activity [GO:0000030] TVRDISYVLATNIYLRK 1 2.2 0.48429 0.19014 0 0 0 0 0 8.45931 0 0 0 0 0 0 Q6NUT3 MFS12_HUMAN Major facilitator superfamily domain-containing protein 12 MFSD12 C19orf28 Homo sapiens (Human) carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021] late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886] cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293] NLSLLVVGVGAVFSLLFHLGTRER 1 5 0.83546 -0.034544 0 7.89748 0 0 5.99343 6.2693 0 7.44344 6.48528 0 7.03617 0 Q6NV74 CRCDL_HUMAN CRACD-like protein CRACDL C2orf55 KIAA1211L Homo sapiens (Human) ASGRLPLAR;GPQDSGDR;LAERGPQDSGDR;MISTRVMDIKLR 4 3.4 0.97645 -2.1988 0 0 11.638 0 0 0 0 0 0 0 9.35456 10.4219 Q6NVH7 SWAP1_HUMAN ATPase SWSAP1 (SWIM-type zinc finger 7-associated protein 1) (SWS1-associated protein 1) (ZSWIM7-associated protein 1) (ZSWIM7AP1) SWSAP1 C19orf39 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821] nucleus [GO:0005634]; Shu complex [GO:0097196] ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697] TALLFAAALEAAGEGQGPVLFLTR;TEWWVTFR 2 14 0.89733 -0.234 0 0 0 0 0 0 0 0 0 4.44075 8.43267 0 Q6NVV3 NIPA3_HUMAN Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3) NIPAL1 NIPA3 NPAL1 Homo sapiens (Human) magnesium ion transport [GO:0015693] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] DPGFISFAVIITVISLVLILIVAPKK 1 6.3 0.37393 0.22364 0 0 0 0 0 0 0 0 7.48663 0 0 0 Q6NVV9 ADAM5_HUMAN "Putative disintegrin and metalloproteinase domain-containing protein 5 (Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II)" ADAM5 ADAM5P TMDC2 Homo sapiens (Human) YIEMHIVVDKNLVLWWCK 1 15.9 0.92138 -0.44131 7.02192 0 0 0 0 0 0 0 0 0 0 0 Q6NVV9 ADAM5_HUMAN "Putative disintegrin and metalloproteinase domain-containing protein 5 (Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II)" ADAM5 ADAM5P TMDC2 Homo sapiens (Human) DETFVQDGSMCGPDMYCFEMHCKHVR 1 8 0.84236 -0.043106 0 0 0 0 0 0 0 7.26922 0 0 0 0 Q6NW29 RWDD4_HUMAN RWD domain-containing protein 4 (Protein FAM28A) RWDD4 FAM28A RWDD4A Homo sapiens (Human) LADKTDHK;LADKTDHKGELPR 2 6.9 0.96637 -1.2762 14.4623 0 14.4077 0 0 0 13.933 13.4955 13.6658 0 0 14.0473 Q6NW34 NEPRO_HUMAN Nucleolus and neural progenitor protein NEPRO C3orf17 Homo sapiens (Human) negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747] nucleolus [GO:0005730]; nucleus [GO:0005634] AQAIFLGNKLLK;INVQNNVDLGQPVKNKR;LSHCTVHR;NMNLEGSIQDLFELFSSKVLYK;VFKEESSEFDVR 5 14.3 0.97265 -2.7435 0 0 0 7.30442 0 0 10.5724 0 0 9.85356 0 0 Q6NW40 RGMB_HUMAN Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON) RGMB Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of DNA-templated transcription [GO:0045893]; signal transduction [GO:0007165] endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] coreceptor activity [GO:0015026]; identical protein binding [GO:0042802] ALRAYAGCTQR 1 2.5 0.88207 -0.17735 12.3003 0 0 0 0 0 0 0 0 0 0 0 Q6NWY9 PR40B_HUMAN Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) PRPF40B HYPC Homo sapiens (Human) "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] RNA binding [GO:0003723] AELLLSQCPWK;AKEAKQTLQHFLEQHER;REAAFRSMLR 3 4.4 0.9645 -1.1644 0 0 0 0 0 0 0 8.8853 7.14486 0 8.14292 0 Q6NX45 ZN774_HUMAN Zinc finger protein 774 ZNF774 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" THTGERPYTCIECGK 1 3.1 0.78349 0.023472 0 0 4.17025 0 0 0 0 0 0 0 0 0 Q6NXE6 ARMC6_HUMAN Armadillo repeat-containing protein 6 ARMC6 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] cytosol [GO:0005829] CVRHACLKHEQNR;QACMLIR;SAHRDCEDVAK 3 6.2 0.97802 -2.1634 0 0 0 0 5.59744 0 0 0 0 0 0 10.4594 Q6NXG1 ESRP1_HUMAN Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) ESRP1 RBM35A Homo sapiens (Human) mRNA processing [GO:0006397]; regulation of inner ear auditory receptor cell fate specification [GO:0042669]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] AFMAAQK;ELILLFWK 2 2.2 0.95451 -0.90793 0 0 0 7.40761 0 0 0 8.5089 0 0 9.18757 0 Q6NXN4 D19P1_HUMAN Putative C-mannosyltransferase DPY19L2P1 (EC 2.4.1.-) (Dpy-19-like protein 2 pseudogene 1) (Protein dpy-19 homolog 2-like 1) DPY19L2P1 Homo sapiens (Human) membrane [GO:0016020] glycosyltransferase activity [GO:0016757] LPGGARR 1 2.9 0.78275 0.022907 0 0 0 8.03375 0 0 0 0 0 0 7.01703 0 Q6NXP0 EFC12_HUMAN EF-hand calcium-binding domain-containing protein 12 EFCAB12 C3orf25 Homo sapiens (Human) calcium ion binding [GO:0005509] DIQEQPEDRKTWLSQR;IIFQMDK;QPGGYYSDWKVFSPNLALLR 3 7.5 0.93666 -0.55535 12.2426 0 0 0 0 0 0 0 0 8.33517 0 10.582 Q6NXP2 GAR1A_HUMAN Golgi-associated RAB2 interactor protein 1A GARIN1A FAM137B FAM71F2 Homo sapiens (Human) acrosome assembly [GO:0001675] Golgi apparatus [GO:0005794] LVKILQKGLSITTK;TVTEKIYYLKLHEK 2 9.3 0.74415 0.088734 0 0 0 10.0077 7.56484 7.5274 0 0 0 0 0 0 Q6NXR0 IIGP5_HUMAN Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) IRGC IIGP5 IRGC1 Homo sapiens (Human) positive regulation of flagellated sperm motility [GO:1902093] lipid droplet [GO:0005811]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm mitochondrial sheath [GO:0097226] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] EAGVADPR;RHAGLLSLPDISLEALQKK;YLKQVDFSR 3 7.8 0.93029 -0.46899 0 0 0 0 7.657 0 0 8.08879 0 0 8.35262 0 Q6NXR4 TTI2_HUMAN TELO2-interacting protein 2 TTI2 C8orf41 Homo sapiens (Human) positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821] nucleus [GO:0005634]; TTT Hsp90 cochaperone complex [GO:0110078] HLKRLER;LILTHMEPEHR;LVVLLKALLK 3 5.5 0.95294 -0.77526 0 0 0 0 10.1777 0 0 0 3.53978 6.415 0 0 Q6NXS1 IPP2B_HUMAN "Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3)" PPP1R2B PPP1R2P3 Homo sapiens (Human) glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] GYGLMKIDEPSPPYHSMMGDDEDACR 1 12.7 0.84167 -0.043106 0 0 0 0 0 0 0 0 0 0 4.67316 0 Q6NXT1 ANR54_HUMAN Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein) ANKRD54 LIAR Homo sapiens (Human) nucleocytoplasmic transport [GO:0006913]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634] protein kinase regulator activity [GO:0019887]; protein-containing complex binding [GO:0044877] LGQHEQRERLDDLCTR 1 5.3 0.84881 -0.070141 0 0 0 0 0 0 0 0 9.24574 8.96509 0 0 Q6NXT4 ZNT6_HUMAN Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) SLC30A6 ZNT6 Homo sapiens (Human) regulation of zinc ion transport [GO:0071579]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion transport [GO:0006829] Golgi apparatus [GO:0005794]; trans-Golgi network membrane [GO:0032588] antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385] LVAADRRSWK;YGTNNRIGQPRP 2 4.8 0.97866 -2.0977 0 0 0 0 8.34194 0 12.4087 0 0 0 0 0 Q6NY19 KANK3_HUMAN KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) KANK3 ANKRD47 Homo sapiens (Human) negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] LTERLATSER 1 1.2 0.98055 -1.5949 0 0 0 0 0 0 0 0 0 8.73122 0 0 Q6NYC1 JMJD6_HUMAN Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) JMJD6 KIAA0585 PSR PTDSR Homo sapiens (Human) "cell surface receptor signaling pathway [GO:0007166]; chromatin remodeling [GO:0006338]; erythrocyte development [GO:0048821]; heart development [GO:0007507]; kidney development [GO:0001822]; lung development [GO:0030324]; macrophage activation [GO:0042116]; mRNA processing [GO:0006397]; negative regulation of protein homooligomerization [GO:0032463]; non-membrane-bounded organelle assembly [GO:0140694]; oxidative RNA demethylation [GO:0035513]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; phagocytosis [GO:0006909]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; recognition of apoptotic cell [GO:0043654]; regulation of mRNA splicing, via spliceosome [GO:0048024]; retina development in camera-type eye [GO:0060041]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; T cell differentiation in thymus [GO:0033077]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] histone demethylase activity [GO:0032452]; histone H3R2 demethylase activity [GO:0033746]; histone H4R3 demethylase activity [GO:0033749]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidative RNA demethylase activity [GO:0035515]; P-TEFb complex binding [GO:0106140]; peptidyl-lysine 5-dioxygenase activity [GO:0070815]; protein demethylase activity [GO:0140457]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537] SSSRIRDTCGGR;TCSMVGNGDTTSQDDCVSK 2 7.5 0.75128 0.079542 0 0 0 0 7.11801 0 0 0 0 0 9.69345 0 Q6NYC8 PPR18_HUMAN Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) PPP1R18 HKMT1098 KIAA1949 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779]; phosphatase binding [GO:0019902] AERERLSQMPAWK;LGIGGAQELSLRPLEARDWR;LSEAWKWR;LSPRETRER 4 8.2 0.97425 -2.4525 8.24246 12.601 0 0 0 0 8.49458 0 0 0 0 0 Q6NZ36 FAP20_HUMAN Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa) FAAP20 C1orf86 FP7162 Homo sapiens (Human) DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985] cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin-modified protein reader activity [GO:0140036] THFHCARVSPNQKLFSNK;VSPNQKLFSNK;VSPNQKLFSNKAK 3 8.7 0.98083 -1.7413 0 17.0774 0 0 6.97085 0 8.6647 0 0 10.0877 0 0 Q6NZI2 CAVN1_HUMAN Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) CAVIN1 PTRF FKSG13 Homo sapiens (Human) positive regulation of cell motility [GO:2000147]; protein secretion [GO:0009306]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134] HTLEKRMNK;LVPAERREK;SFTPDHVVYAR 3 7.4 0.97699 -1.4963 13.4848 0 0 0 0 0 0 11.1981 0 0 12.5355 0 Q6NZY4 ZCHC8_HUMAN Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) ZCCHC8 Homo sapiens (Human) "co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway [GO:0180034]; mRNA 3'-end processing [GO:0031124]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; snRNA catabolic process [GO:0016076]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] LFPADTSPSTATK 1 1.8 0.88078 -0.14694 0 0 0 0 0 0 0 0 0 0 0 9.83942 Q6P050 FXL22_HUMAN F-box and leucine-rich protein 22 FBXL22 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleolus [GO:0005730]; Z disc [GO:0030018] ubiquitin protein ligase activity [GO:0061630] DNFLLGPALRSLSICWHSSR;LSAVRSPR 2 11.3 0.91726 -0.35541 0 0 0 0 0 0 8.91181 0 11.11 10.212 0 0 Q6P087 RUSD3_HUMAN Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) RPUSD3 Homo sapiens (Human) mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] EQELQVVR;NLSREELVDALR 2 5.7 0.93699 -0.57635 0 0 0 0 0 0 11.2776 0 0 0 10.0147 0 Q6P093 ADCL2_HUMAN Arylacetamide deacetylase-like 2 (EC 3.1.1.-) AADACL2 Homo sapiens (Human) extracellular region [GO:0005576]; membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] DEALPWAMRR 1 2.5 0.71145 0.15484 0 0 0 0 0 0 0 0 0 0 9.6825 0 Q6P0N0 M18BP_HUMAN Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) MIS18BP1 C14orf106 KIAA1903 KNL2 M18BP1 Homo sapiens (Human) cell division [GO:0051301] "chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]" DNA binding [GO:0003677] IYLPPEASSQRR;KYMENPR;NQVVQLQEWMIK;TTEGTSQQK 4 3.5 0.94151 -0.60339 7.76248 0 10.2798 10.6539 4.30633 3.1944 0 0 10.8015 0 0 0 Q6P0Q8 MAST2_HUMAN Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) MAST2 KIAA0807 MAST205 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of interleukin-12 production [GO:0032655]; spermatid differentiation [GO:0048515] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatase binding [GO:0019902]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CRDRPQPPPPDRR;INKQNLILR;LLSGDSTEK;LSMWSWK;QSPAMRPRSRSLSPGR;YGFTLRAIR 6 3.5 0.97443 -2.4477 0 0 0 0 6.2632 6.33196 0 12.8567 0 7.37121 0 12.6724 Q6P158 DHX57_HUMAN Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GNCKFGSKCR;YDWQAKSVHAENGKICK;YSDPPVNFLPVPSRTR 3 3.1 0.98055 -2.0156 0 0 0 0 0 0 10.7372 0 0 6.67878 7.07168 0 Q6P179 ERAP2_HUMAN Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP) ERAP2 LRAP Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020] aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] FSYRNAK;GACILNMLK;LLKLIELGMEGKVIK;VIKTQNLAALLHAIARRPK 4 4.9 0.9803 -1.8147 0 12.2502 8.21447 6.20365 0 0 6.97016 13.3168 0 0 0 12.5753 Q6P1J6 PLB1_HUMAN "Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A2) (EC 3.1.1.4) (Phospholipase B/lipase) (PLB/LIP) (Triacylglycerol lipase) (EC 3.1.1.3)" PLB1 PLB Homo sapiens (Human) diacylglycerol catabolic process [GO:0046340]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol catabolic process [GO:0034478]; phospholipid metabolic process [GO:0006644]; positive regulation of acrosome reaction [GO:2000344]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806] ETSPNAFLNQAVAGGR;LGVNMPSK;QVFLGNPDK 3 2.3 0.96397 -1.184 0 0 13.2154 0 0 0 0 0 0 0 0 0 Q6P1J9 CDC73_HUMAN Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) CDC73 C1orf28 HRPT2 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; regulation of cell growth [GO:0001558]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] "Cdc73/Paf1 complex [GO:0016593]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" RNA polymerase II complex binding [GO:0000993] DQMQPGGTAISVTVPYR;SVTEGASAR;YDQERFK 3 6.2 0.97924 -1.8962 0 0 0 0 0 0 0 0 10.486 0 0 0 Q6P1K2 PMF1_HUMAN Polyamine-modulated factor 1 (PMF-1) PMF1 Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]; transcription regulator complex [GO:0005667] leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713] CFYQLQPAMTQQIYDKFIAQLQTSIR 1 12.7 0.84213 -0.043106 0 9.9305 0 0 0 0 0 0 0 0 0 0 Q6P1K8 T2H2L_HUMAN General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) GTF2H2C; GTF2H2C_2 GTF2H2D Homo sapiens (Human) DNA-templated transcription [GO:0006351]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear speck [GO:0016607]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] zinc ion binding [GO:0008270] IPAPSGV 1 1.8 0.71069 0.15645 0 5.33782 0 0 0 0 6.66959 0 0 8.54249 0 0 Q6P1L5 F117B_HUMAN Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) FAM117B ALS2CR13 Homo sapiens (Human) TSPTVATQTGASATSTR 1 2.9 0.78472 0.027337 0 0 0 0 8.85935 0 0 0 0 0 0 0 Q6P1L6 ZN343_HUMAN Zinc finger protein 343 ZNF343 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" ETSRAFPSPLQRQSASPR;IHSGEKPYVCRECGR 2 5.5 0.89703 -0.24028 0 0 8.17762 0 0 0 0 0 0 8.41886 0 0 Q6P1L8 RM14_HUMAN "Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32)" MRPL14 MRPL32 RPML32 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VGDQILLAIKGQKK 1 9.7 0.86899 -0.090719 9.75954 0 0 0 0 0 0 0 0 0 0 0 Q6P1M0 S27A4_HUMAN Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-) SLC27A4 ACSVL4 FATP4 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; establishment of localization in cell [GO:0051649]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of apoptotic process [GO:0043065]; response to nutrient [GO:0007584]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]; very long-chain fatty acid catabolic process [GO:0042760] brush border membrane [GO:0031526]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957] DALLHCLTTSRAR;DPLFYLDAQKGR;QSIWTNFSSR;VRQCLQER 4 6.7 0.97523 -3.9721 0 9.24878 0 0 0 12.1491 12.447 0 0 0 9.22701 0 Q6P1M3 L2GL2_HUMAN LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) LLGL2 Homo sapiens (Human) cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; L-leucine transport [GO:0015820]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593] adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165] LLYKLSTVR;LVAFGTSHGFGLFDHQQRR;SLVPYGPFPCKAITRILWLTTR;TLYFADTYLK 4 5.9 0.78391 0.02595 8.5841 11.3677 0 0 7.59701 0 8.51187 0 0 0 0 0 Q6P1M9 ARMX5_HUMAN Armadillo repeat-containing X-linked protein 5 ARMCX5 Homo sapiens (Human) EKYGPNPKACHCK;VEDTTKTRVMVETK 2 4.8 0.97321 -1.3763 0 0 0 0 0 0 0 0 0 0 8.07071 0 Q6P1N0 C2D1A_HUMAN Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) CC2D1A AKI1 LGD2 Homo sapiens (Human) apical dendrite arborization [GO:0150023]; endosome organization [GO:0007032]; negative regulation of snRNA transcription by RNA polymerase II [GO:1905381]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of postsynapse assembly [GO:0150052]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LCINRSHR;QKNDVEGAKMHLR;QQGDTTAAARHFRVAK 3 3.9 0.97565 -3.4341 0 0 0 9.97025 0 10.3232 0 0 0 0 0 0 Q6P1N9 TATD1_HUMAN Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein) TATDN1 CDA11 Homo sapiens (Human) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] 3'-5'-DNA exonuclease activity [GO:0008296]; metal ion binding [GO:0046872] HQDDLQDVIGR;LQFCPKDTQLK;LQFCPKDTQLKYFEK 3 8.8 0.89277 -0.22435 9.26357 10.5149 0 0 0 0 0 0 0 6.8874 0 8.41663 Q6P1N9 TATD1_HUMAN Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein) TATDN1 CDA11 Homo sapiens (Human) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] 3'-5'-DNA exonuclease activity [GO:0008296]; metal ion binding [GO:0046872] LQFCPKDTQLK;LQFCPKDTQLKYFEK;MITGGNLQDSK 3 10.4 0.89735 -0.23401 0 0 0 9.10648 0 0 0 0 0 0 0 0 Q6P1Q0 LTMD1_HUMAN LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2) LETMD1 Homo sapiens (Human) mitochondrion organization [GO:0007005]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090]; ribosome binding [GO:0043022] AMLLTSYLPPPLLRHRLK;ECFSNHPLGMNQLQALHVK;GLQMLWADAKK;LTDLCTK;VIPLISDAGLRWR 5 18.9 0.95243 -0.74318 10.6457 5.90629 0 0 0 0 11.9486 0 0 8.96593 0 0 Q6P1Q0 LTMD1_HUMAN LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2) LETMD1 Homo sapiens (Human) mitochondrion organization [GO:0007005]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090]; ribosome binding [GO:0043022] FYVLYTIFMKGTCFPGNY 1 18.2 0.92186 -0.44111 0 0 0 0 0 0 0 7.42223 0 0 0 0 Q6P1Q9 MET2B_HUMAN tRNA N(3)-cytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B) METTL2B Homo sapiens (Human) tRNA metabolic process [GO:0006399]; tRNA methylation [GO:0030488] cytoplasm [GO:0005737] tRNA (cytidine) methyltransferase activity [GO:0016427]; tRNA (cytidine-3-)-methyltransferase activity [GO:0052735] DWFLENKSEVCECR;IHENGFFK;LSRLLKPGGMVLLR 3 9.5 0.9651 -1.1215 4.86022 0 5.66306 0 0 0 0 0 7.38759 0 0 0 Q6P1R3 MSD2_HUMAN Myb/SANT-like DNA-binding domain-containing protein 2 MSANTD2 C11orf61 Homo sapiens (Human) IIYCYLGIAEVR 1 2.1 0.80474 0.013151 0 0 3.47949 5.13291 0 0 9.06172 8.78901 0 0 0 0 Q6P1S2 CC033_HUMAN Protein C3orf33 (Protein AC3-33) C3orf33 MSTP052 Homo sapiens (Human) negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of DNA-binding transcription factor activity [GO:0051090] extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739] AIAGIMLLLRSIRLTSK 1 6.8 0.56292 0.18261 0 0 0 0 0 0 0 0 0 5.51163 0 0 Q6P1X5 TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (150 kDa cofactor of initiator function) (RNA polymerase II TBP-associated factor subunit B) (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) TAF2 CIF150 TAF2B Homo sapiens (Human) G2/M transition of mitotic cell cycle [GO:0000086]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] chromatin binding [GO:0003682]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976] EVLTFILDLIK;LILEEITRFLNMEK;NVLELEIKQDYTSPGTQK;TFGVNEYRHWIK 4 4.6 0.96704 -1.2993 0 9.93661 0 0 0 0 0 9.70351 10.3507 6.60432 0 0 Q6P1X6 CH082_HUMAN UPF0598 protein C8orf82 C8orf82 Homo sapiens (Human) mitochondrion [GO:0005739] DPQFLVTFFSRLRPNRSGR;TREYFYYVDHQGQLFLDDSK 2 18.1 0.95223 -0.74387 0 0 9.95616 0 0 0 0 0 0 0 0 11.1087 Q6P280 ZN529_HUMAN Zinc finger protein 529 ZNF529 KIAA1615 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IISENVPSYK;ISSQLIEHQR 2 3.6 0.95494 -0.87701 0 0 0 0 0 0 0 10.1037 0 0 0 0 Q6P2C8 MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34) MED27 CRSP34 CRSP8 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; cytosol [GO:0005829]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] DGMRNKETLEGR;VLKVIVVMR;VLKVIVVMRSLFIDR 3 8.7 0.9163 -0.43352 0 0 0 3.66869 0 3.93045 0 0 9.06816 0 0 0 Q6P2C8 MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34) MED27 CRSP34 CRSP8 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; cytosol [GO:0005829]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] DGMRNKETLEGR;KEQLSIPRIFHWK 2 19.2 0.86533 -0.091983 0 0 0 0 0 0 0 0 11.6391 0 0 0 Q6P2D0 ZFP1_HUMAN Zinc finger protein 1 homolog (Zfp-1) (Zinc finger protein 475) ZFP1 ZNF475 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ALLYLKQEK;NLVQPFICTYCDK;RYECSECGKSFIQNSQLIIHMR;SFIQNSQLIIHMR;STLRLHLR 5 12.8 0.97459 -3.0578 0 7.45968 9.83026 8.54237 0 0 0 0 0 4.89074 8.72175 0 Q6P2D8 XRRA1_HUMAN X-ray radiation resistance-associated protein 1 XRRA1 Homo sapiens (Human) response to X-ray [GO:0010165] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ARNQTLAPPFPELR;DVDRTTTK;ELDLAFNGIK;NAQALQQMLKHPLLCHSSKPK;TRAQLLDDIFIR;YILRFPALETLMLDDNR 6 10.5 0.97614 -4.5435 0 0 17.185 0 0 0 0 0 11.6099 7.80284 0 0 Q6P2D8 XRRA1_HUMAN X-ray radiation resistance-associated protein 1 XRRA1 Homo sapiens (Human) response to X-ray [GO:0010165] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DVDRTIAK;ELDLAFNGIK;NAQALQQMLKHPLLCHSSKPK;TRAQLLDDIFIR;YILRFPALETLMLDDNR 5 9.2 0.91298 -0.33804 12.0144 0 0 0 0 0 0 0 0 0 0 0 Q6P2E9 EDC4_HUMAN Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) EDC4 HEDLS Homo sapiens (Human) deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] ETCSTLAESPR;IVELPAPADFLSLSSETKPK;NLTDAIAR;SSHSTWPVDVSQIK 4 3.8 0.0045455 1.2138 6.94369 0 0 0 0 0 9.54131 0 0 0 10.1335 0 Q6P2H3 CEP85_HUMAN Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) CEP85 CCDC21 Homo sapiens (Human) cell migration [GO:0016477]; centriole assembly [GO:0098534]; centriole replication [GO:0007099]; chromosome segregation [GO:0007059]; negative regulation of protein kinase activity [GO:0006469]; regulation of mitotic centrosome separation [GO:0046602] cell cortex [GO:0005938]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922] identical protein binding [GO:0042802] ELLIDKQR;ELYRVLPEAKK;IVEKQQQK;VTELESLLEETQAICR 4 5.6 0.98101 -1.7108 0 0 7.32247 0 0 0 0 12.828 0 9.01106 0 0 Q6P2M8 KCC1B_HUMAN Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase) PNCK Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] AESLADLWPK;GGEGRDWKAESLADLWPK;IMERGSYTEK;KHTEDISSVYEIR;THWKRAFNATSFLR 5 12.9 0.975 -3.0854 0 0 12.1444 0 0 8.8759 0 12.0982 0 10.3853 0 0 Q6P2P2 ANM9_HUMAN Protein arginine N-methyltransferase 9 (Protein arginine N-methyltransferase 10) (EC 2.1.1.320) PRMT9 PRMT10 Homo sapiens (Human) chromatin remodeling [GO:0006338]; methylation [GO:0032259]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737] histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243] SLATKKPDKIGIPVIK;WAEELDALSR 2 3.1 0.95282 -0.77444 0 0 0 0 0 0 0 5.6931 0 0 0 0 Q6P2Q9 PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) PRPF8 PRPC8 Homo sapiens (Human) "cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] FNTGPVGK;INTLFQK;LLKYYVLNALKHRPPK;LTPSGYEWGR;NLGRLTRLYLK;SLPVEEQPK;TAEEVAALIR;TEDPDLPAFYFDPLINPISHR;TILQHLSEAWR;TISSYTAFSR;TNHIYVSSDDIK;TNHIYVSSDDIKETGYTYILPK;VQMLLSDR;VWAEYALKRQEAIAQNR 14 6.9 0.97463 -3.6796 13.8448 14.2586 13.4755 6.10478 9.04789 7.38396 0 10.415 12.7958 0 0 0 Q6P2S7 TTC41_HUMAN Putative tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase) TTC41P GNN Homo sapiens (Human) cytoplasm [GO:0005737] CAPGKGK;IGKLKAK;INPTPTYK;IQSLGFWTRLHLIHFWNVLLEAGYDVSEAYLLSVAK;LSLSDLEDSR;QMCVISKESDRTFEILEK;WIEDYSWTFQPKR;YFQRQTSFWR;YWPQGMSQQHSEGSR 9 9.4 0.97421 -3.789 0 7.02989 9.10847 0 0 7.56849 0 11.3967 0 7.90617 7.49402 0 Q6P387 CP046_HUMAN Uncharacterized protein C16orf46 C16orf46 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] GLSIPGPLTSRALLVLPPLK 1 5.1 0.81876 -0.01737 0 0 0 0 0 0 0 0 4.21117 0 0 0 Q6P3R8 NEK5_HUMAN Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 Homo sapiens (Human) 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FQELPFRKNEMK;HGPSPSQWPAEYLQRK;ICQAHFAPISPGFSR;KFEAQQYK;VLNNSMELAR;YDVIKAIGQGAFGKAYLAK 6 11.2 0.97391 -3.0252 5.775 13.2571 9.80053 0 0 10.6936 11.4026 0 0 0 0 0 Q6P3S1 DEN1B_HUMAN DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) DENND1B C1orf218 FAM31B Homo sapiens (Human) endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] LAQARLK;LAQARLKRPLK;LGLKEVKSK 3 2.6 0.89544 -0.22831 6.16144 0 0 0 8.22197 0 0 0 0 0 2.99926 0 Q6P3V2 Z585A_HUMAN Zinc finger protein 585A ZNF585A Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QVSSQPQK;TFRQKSELITHHR 2 2.7 0.94423 -0.62655 0 0 0 0 0 7.03122 0 0 0 0 12.6788 0 Q6P3W2 DJC24_HUMAN DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4) DNAJC24 DPH4 ZCSL3 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; positive regulation of ATP-dependent activity [GO:0032781]; protein histidyl modification to diphthamide [GO:0017183] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATPase activator activity [GO:0001671]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270] ILGNEETKREYDLQR;KDWYSILGADPSANISDLK;LILMYHPDK 3 28.9 0.91366 -0.38116 0 0 8.06113 9.4006 0 0 0 0 0 0 0 0 Q6P3W7 SCYL2_HUMAN SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) SCYL2 CVAK104 KIAA1360 Homo sapiens (Human) brain development [GO:0007420]; clathrin-dependent endocytosis [GO:0072583]; endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; pyramidal neuron development [GO:0021860]; receptor internalization [GO:0031623] clathrin-coated vesicle [GO:0030136]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102] LESEHKTK;LYDVETK;QQEPIQILLIFLQKMDLLLTK 3 3.9 0.97849 -1.9413 0 0 0 0 0 0 0 0 0 9.26892 0 0 Q6P3X3 TTC27_HUMAN Tetratricopeptide repeat protein 27 (TPR repeat protein 27) TTC27 Homo sapiens (Human) AYHRLLDLR;DQLDIAK;SARAQRSK;VTNDGEIWR 4 3.9 0.97496 -3.2187 0 0 0 0 0 0 7.48091 0 0 9.35154 0 0 Q6P3X8 PGBD2_HUMAN PiggyBac transposable element-derived protein 2 PGBD2 Homo sapiens (Human) sequence-specific DNA binding [GO:0043565] LTSRHSGAAK;VDESEEIIVCR 2 3.5 0.96451 -1.2232 0 0 0 0 0 0 7.35553 0 0 0 0 0 Q6P435 SMG1L_HUMAN Putative uncharacterized SMG1-like protein Homo sapiens (Human) SMSYCDESRLSNLLR 1 9.4 0.9512 -0.70533 0 0 0 0 0 0 0 0 0 0 0 9.39579 Q6P444 MTFR2_HUMAN Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) MTFR2 DUFD1 FAM54A Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005] mitochondrion [GO:0005739] ENRSWESSPFSSPETSR;ETVKNDLPVNEAAIRK;ISLGQLSSSR;NDLPVNEAAIRK;NSTNSSSFGLSDER 5 14.8 0.98041 -1.5521 8.95571 2.50042 0 0 0 0 0 0 0 8.81503 0 0 Q6P461 ACSM6_HUMAN "Acyl-coenzyme A synthetase ACSM6, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 6)" ACSM6 C10orf129 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872] LLVSDKSYDGWLDFK 1 3.1 0.89249 -0.21263 0 0 0 0 0 0 0 0 0 0 0 9.38993 Q6P474 PDXD2_HUMAN Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC 4.1.1.-) (pyridoxal-dependent decarboxylase domain-containing 2 pseudogene) PDXDC2P PDXDC2 Homo sapiens (Human) carboxylic acid metabolic process [GO:0019752] intracellular membrane-bounded organelle [GO:0043231] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] IADPTLAEMGK;IKHACQLSQWLQESLK;IKHACQLSQWLQESLKK 3 6 0.9773 -1.5239 0 0 0 0 8.67881 10.6676 0 0 8.62077 0 0 0 Q6P499 NPAL3_HUMAN NIPA-like protein 3 NIPAL3 NPAL3 Homo sapiens (Human) magnesium ion transport [GO:0015693] membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] LAGSKDPR 1 2 0.97282 -1.3686 0 0 0 0 0 0 0 0 9.23628 0 0 0 Q6P4A8 PLBL1_HUMAN Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C] PLBD1 Homo sapiens (Human) phospholipid catabolic process [GO:0009395] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] phospholipase activity [GO:0004620] HTGYVMAQIDGLYVGAKKR;QDKWTRK;VTDTASMKYIMR;YIMRYNNYK 4 7.8 0.97975 -1.8407 0 8.47391 0 0 0 0 5.36198 8.48184 0 0 0 0 Q6P4D5 PBIR3_HUMAN PABIR family member 1 PABIR3 FAM122C Homo sapiens (Human) protein serine/threonine phosphatase inhibitor activity [GO:0004865] LVKWHFNINQK;LVKWHFNINQKR 2 6.2 0.93673 -0.54286 0 0 0 0 0 0 0 0 10.8726 0 11.2457 0 Q6P4D5 PBIR3_HUMAN PABIR family member 1 PABIR3 FAM122C Homo sapiens (Human) protein serine/threonine phosphatase inhibitor activity [GO:0004865] EPESLENLFLDPDMAQEK 1 15.7 0.78359 0.022377 0 0 0 0 0 0 0 0 8.68944 0 0 0 Q6P4F1 FUT10_HUMAN "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" FUT10 Homo sapiens (Human) cerebral cortex radially oriented cell migration [GO:0021799]; fertilization [GO:0009566]; fucosylation [GO:0036065]; hemopoiesis [GO:0030097]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuronal stem cell division [GO:0036445]; neuronal stem cell population maintenance [GO:0097150]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]; protein glycosylation [GO:0006486]; protein targeting [GO:0006605]; wound healing [GO:0042060] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] EVMVELGK 1 1.5 0.93686 -0.53908 0 0 0 9.74382 0 0 0 0 0 0 0 0 Q6P4F2 FDX2_HUMAN "Ferredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein)" FDX2 FDX1L Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226]; P450-containing electron transport chain [GO:0140647] iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]" TRGWAARLC 1 6.3 0.82531 -0.020335 0 0 0 0 0 0 0 0 0 10.9324 0 0 Q6P4F7 RHGBA_HUMAN Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) ARHGAP11A KIAA0013 Homo sapiens (Human) positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] AFYGIKVKGVR;DIHSNMPK;LALLQHLR;LVRLALLQHLR;MSSNTEK 5 3.6 0.97227 -2.8306 0 0 0 13.19 5.83575 0 0 0 7.8358 8.91645 6.69488 0 Q6P4I2 WDR73_HUMAN WD repeat-containing protein 73 WDR73 HSPC264 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922] SQDGTRSQVEPLFTHR 1 4.2 0.95159 -0.70451 0 0 0 0 0 0 0 0 10.0745 0 0 0 Q6P4Q7 CNNM4_HUMAN Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) CNNM4 ACDP4 KIAA1592 Homo sapiens (Human) enamel mineralization [GO:0070166]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; visual perception [GO:0007601] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081] IEPIRRK;IVQNCGTEK;LLLAAPVLLVLLWALGAR;TVYNREK;VEVEAGK 5 6.2 0.97378 -3.0216 0 7.09487 0 0 5.49047 9.85484 9.72421 9.47925 8.80181 0 0 0 Q6P4R8 NFRKB_HUMAN Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) NFRKB INO80G Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; protease binding [GO:0002020] DGHFNPEVVK;DQAFCKQENEDSSDATTPVPR;GVFDKETSLNK;LPTRITVPLSVISQPMK 4 4.5 0.95624 -0.83966 0 7.60681 0 0 0 9.30351 0 0 0 0 0 0 Q6P587 FAHD1_HUMAN "Oxaloacetate tautomerase FAHD1, mitochondrial (EC 5.3.2.2) (Acylpyruvase FAHD1) (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (ODx) (EC 4.1.1.112) (YisK-like protein)" FAHD1 C16orf36 YISKL Homo sapiens (Human) oxaloacetate metabolic process [GO:0006107]; pyruvate metabolic process [GO:0006090] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; metal ion binding [GO:0046872]; oxaloacetate decarboxylase activity [GO:0008948]; oxaloacetate tautomerase activity [GO:0050163] DVQDECK;IPDPHKLKLWLK;NLHHELELGVVMGK 3 14.9 0.95434 -0.88651 0 0 0 0 0 0 3.86305 0 0 0 0 11.0111 Q6P589 TP8L2_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20) TNFAIP8L2 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell activation [GO:0050868]; regulation of apoptotic process [GO:0042981]; T cell activation [GO:0042110] cytoplasm [GO:0005737]; lysosome [GO:0005764]; nucleus [GO:0005634] VIKDLIKVAIK 1 6 0.30414 0.25031 0 0 7.08937 0 0 0 0 0 0 0 0 0 Q6P5Q4 LMOD2_HUMAN Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) LMOD2 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]; sarcomere organization [GO:0045214] actin filament [GO:0005884]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523] ALQHNTVLTELR 1 2.2 0.89784 -0.23831 0 0 0 7.92908 0 0 0 0 0 0 0 0 Q6P5Q4 LMOD2_HUMAN Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) LMOD2 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838]; sarcomere organization [GO:0045214] actin filament [GO:0005884]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523] SSNNRRVPNGHYK 1 10.1 0.97758 -1.5218 0 0 0 0 0 10.0018 0 0 0 0 0 0 Q6P5S2 LEG1H_HUMAN Protein LEG1 homolog LEG1 C6orf58 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular space [GO:0005615] SFEDRYDYYSK;SIGYLCTEK 2 6.1 0.95288 -0.76351 0 0 0 0 0 0 0 0 0 0 8.73745 0 Q6P5W5 S39A4_HUMAN Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) SLC39A4 ZIP4 Homo sapiens (Human) cellular response to zinc ion starvation [GO:0034224]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion binding [GO:0008270]; zinc ion sensor activity [GO:0106219]; zinc ion sequestering activity [GO:0140486]; zinc ion transmembrane transporter activity [GO:0005385] LGVGREAHSDHSHRHR 1 2.5 0.8508 -0.075267 0 0 3.41414 0 0 0 0 0 0 0 0 0 Q6P5Z2 PKN3_HUMAN Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) PKN3 PKNBETA Homo sapiens (Human) epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]" CPEKRLGAGEQDAEEIK;VLLVQFKGTGKYYAIK;YYAIKALKK 3 4.2 0.96529 -1.1496 0 0 0 0 0 6.44458 0 0 7.18725 3.6472 0 0 Q6P6B7 ANR16_HUMAN Ankyrin repeat domain-containing protein 16 ANKRD16 Homo sapiens (Human) tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] ADWTPLMMACTRK;FLLQSGLKDSEDITGTLAQQLPR;RLCRLVQEGR 3 12.7 0.91352 -0.38127 0 12.3142 9.67276 0 0 0 0 4.51324 0 0 0 0 Q6P6C2 ALKB5_HUMAN RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) ALKBH5 ABH5 OFOXD1 Homo sapiens (Human) cell differentiation [GO:0030154]; gamma-delta T cell proliferation [GO:0046630]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of translation [GO:0006417]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; RNA binding [GO:0003723] KADPDAAHRPRILEMDK;LSGNNRDPALKPK 2 7.6 0.90165 -0.262 0 8.69721 8.42383 0 0 0 0 0 0 0 0 7.72948 Q6P995 F171B_HUMAN Protein FAM171B FAM171B KIAA1946 NPD019 Homo sapiens (Human) membrane [GO:0016020]; synapse [GO:0045202] ARLVPAAARAELSR;SNGAVLIKVPYKLGLSLTIIAYK 2 4.5 0.74414 0.090068 0 0 0 0 8.40032 0 0 0 0 0 9.57245 0 Q6P996 PDXD1_HUMAN Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) PDXDC1 KIAA0251 Homo sapiens (Human) carboxylic acid metabolic process [GO:0019752] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] cadherin binding [GO:0045296]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] IADPTLAEMGK;LLENMTEVVRK;LNELESDLTFKIGPEYKSMK 3 5.3 0.97601 -2.3454 0 11.5579 0 0 0 0 0 0 0 0 0 11.7623 Q6P9A2 GLT18_HUMAN Polypeptide N-acetylgalactosaminyltransferase 18 (EC 2.4.1.41) (Polypeptide GalNAc transferase 18) (GalNAc-T18) (Polypeptide GalNAc transferase-like protein 4) (GalNAc-T-like protein 4) (pp-GaNTase-like protein 4) (Polypeptide N-acetylgalactosaminyltransferase-like protein 4) (Protein-UDP acetylgalactosaminyltransferase-like protein 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4) GALNT18 GALNTL4 Homo sapiens (Human) protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] ALRKQLQCK 1 1.5 0.97538 -1.4384 0 0 0 0 0 9.31628 0 0 0 0 0 0 Q6P9A3 ZN549_HUMAN Zinc finger protein 549 ZNF549 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AYECSDCGK;EQLCECNECGK;GFYLEVK;LLQHQRIHTR 4 5.8 0.95534 -0.86284 0 0 0 0 10.4759 0 11.3534 0 5.32841 0 0 8.15487 Q6P9B6 MEAK7_HUMAN "MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1)" MEAK7 KIAA1609 TLDC1 Homo sapiens (Human) negative regulation of cellular response to oxidative stress [GO:1900408]; positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] EAPGPNPR 1 1.8 0.74274 0.10231 0 0 0 0 0 0 0 0 0 8.44166 0 0 Q6P9B9 INT5_HUMAN Integrator complex subunit 5 (Int5) INTS5 KIAA1698 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LSQTSPAGLK;LVPFLDALK 2 1.9 0.95268 -0.7638 0 0 10.6947 0 0 0 0 0 0 8.86434 0 0 Q6P9F0 CCD62_HUMAN Coiled-coil domain-containing protein 62 (Protein TSP-NY) (Protein aaa) CCDC62 Homo sapiens (Human) blastocyst hatching [GO:0001835]; cellular response to estradiol stimulus [GO:0071392]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; nucleus [GO:0005634] nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374] ATHSSLLSEDLEAR;MAETCIVK;NEACLGESGMCDSK;SEISCCQKNEACLGESGMCDSK;TTENNEQREEIIR 5 8.3 0.97393 -2.4258 0 0 1.97471 0 0 0 8.53687 0 9.61298 0 0 0 Q6P9F7 LRC8B_HUMAN Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) LRRC8B KIAA0231 UNQ6413/PRO21207 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] DIIYRVYLKQIIVK;FRMHVEQKDIIYR;LVVLNNLK;QLHWFAK 4 4.6 0.96589 -1.1262 0 13.9714 14.0073 0 0 0 0 10.8849 0 0 0 0 Q6P9G9 ZN449_HUMAN Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19) ZNF449 ZSCAN19 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; spermatogonial cell division [GO:0007284] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AGLIMHQVTHFR;EEPWVKELQDSKEMK 2 5.2 0.94439 -0.6314 0 0 0 0 0 0 0 0 10.5327 0 0 9.93857 Q6P9H4 CNKR3_HUMAN Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737] IPPIIEESSSPPYR 1 2.5 0.87588 -0.12901 0 0 0 0 0 0 0 0 0 0 0 8.80581 Q6P9H5 GIMA6_HUMAN GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6) GIMAP6 IAN2 IAN6 Homo sapiens (Human) cytosol [GO:0005829] GTP binding [GO:0005525] LQEVFGVGVLGHTILVFTR;LSTRPVTK 2 9.2 0.89581 -0.24238 9.66958 12.8119 0 0 0 6.50851 13.1332 0 0 0 0 0 Q6PB30 CSAG1_HUMAN Chondrosarcoma-associated gene 1 protein (Cancer/testis antigen 24.1) (CT24.1) (Cancer/testis antigen CSAGE) CSAG1 CSAGE Homo sapiens (Human) centrosome cycle [GO:0007098] centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] EVPGTKGSP 1 11.5 0.90289 -0.26327 0 0 0 0 0 0 0 7.5519 0 0 0 0 Q6PCB0 VWA1_HUMAN von Willebrand factor A domain-containing protein 1 VWA1 Homo sapiens (Human) behavioral response to pain [GO:0048266]; extracellular matrix organization [GO:0030198]; protein homooligomerization [GO:0051260] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614] microfibril binding [GO:0050436]; protein homodimerization activity [GO:0042803] GAQGPGR 1 10.9 0.82251 -0.017923 11.6939 0 0 0 0 0 0 0 0 0 0 0 Q6PCB5 RSBNL_HUMAN Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) RSBN1L Homo sapiens (Human) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] AKLDHVQFAEFKIDMDSK;HEPIASVRIK 2 3.3 0.98115 -1.7089 0 0 12.2297 0 7.72772 0 0 0 0 0 0 0 Q6PCB6 AB17C_HUMAN Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22) ABHD17C FAM108C1 Homo sapiens (Human) negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; regulation of postsynapse organization [GO:0099175] dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] ADWQYSQR;ELDAVEVFFSR 2 5.8 0.95245 -0.67263 13.074 12.812 12.6216 0 10.223 9.98598 0 0 0 0 0 10.8025 Q6PCB7 S27A1_HUMAN Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-) SLC27A1 ACSVL5 FATP1 Homo sapiens (Human) adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]; transport across blood-brain barrier [GO:0150104] basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957] EGFDPRQTSDRLFFLDLK;ILPHVYPIRLVK;IVCKTAR;LAVGNGLRPAIWEEFTER;TRLQREGFDPR 5 9.3 0.97323 -2.9386 0 11.6316 6.69028 0 0 9.71409 10.8437 0 10.3494 0 0 7.40054 Q6PCB8 EMB_HUMAN Embigin EMB Homo sapiens (Human) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; plasma membrane lactate transport [GO:0035879] axon [GO:0030424]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] ALPGLLEARAR 1 3.4 0.9805 -1.5534 2.17859 0 0 0 8.87731 0 0 0 0 0 0 10.3158 Q6PCD5 RFWD3_HUMAN E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) RFWD3 RNF201 Homo sapiens (Human) DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297]; response to ionizing radiation [GO:0010212] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734] MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; ubiquitin protein ligase activity [GO:0061630] EQMLRKQAELESAQCR;MLSTANMK 2 3.1 0.94179 -0.61847 0 0 0 9.43075 0 0 0 0 0 11.6356 0 0 Q6PCE3 PGM2L_HUMAN "Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1)" PGM2L1 BM32A Homo sapiens (Human) glucose metabolic process [GO:0006006] cytosol [GO:0005829] "glucose-1,6-bisphosphate synthase activity [GO:0047933]; intramolecular phosphotransferase activity [GO:0016868]; metal ion binding [GO:0046872]" VYEKYGYHISK 1 1.8 0.88569 -0.18226 0 0 0 0 0 7.80639 0 0 0 0 0 0 Q6PCT2 FXL19_HUMAN F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) FBXL19 FBL19 Homo sapiens (Human) chromatin remodeling [GO:0006338]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] EAGNEPPTPRK;FGGPGRMK;GPGAGAR;KVGGDACLLR;MKQSCLLRQCTAPVLPHTAVCLLCGEAGK;TECGDCHFCR;VGGDACLLRGSDPGGPGLLPPR 7 12.4 0.95317 -0.72726 0 0 4.52463 5.91757 0 9.66327 10.7474 11.2572 0 0 0 5.57416 Q6PD62 CTR9_HUMAN RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) CTR9 KIAA0155 SH2BP1 Homo sapiens (Human) "blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; inner cell mass cell differentiation [GO:0001826]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; trophectodermal cell differentiation [GO:0001829]; Wnt signaling pathway [GO:0016055]" Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] RNA polymerase II complex binding [GO:0000993]; SH2 domain binding [GO:0042169] CASSESDSDENQNK;DYRGALAYYK;GSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD;GSEHGSDDSD;ILGSLYAASEDQEKR;ILQEKVQADVPPEILNNVGALHFRLGNLGEAK;RGGGGGR 7 9.8 0.97958 -1.9977 0 0 0 0 7.48856 3.97737 0 0 4.83799 0 0 0 Q6PD74 AAGAB_HUMAN Alpha- and gamma-adaptin-binding protein p34 AAGAB Homo sapiens (Human) protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607] YYSADINLCVVPNK 1 4.4 0.78549 0.018147 0 0 0 0 0 0 0 0 0 0 0 7.62578 Q6PDA7 SG11A_HUMAN Sperm-associated antigen 11A (Antimicrobial-like protein Bin-1b) (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2) SPAG11A BIN1B EP2 HE2 Homo sapiens (Human) defense response to bacterium [GO:0042742] extracellular region [GO:0005576] RDLLPPRTPPYQGTGQQHR 1 23.2 0.85835 -0.081332 0 0 0 6.03192 0 0 0 0 0 0 0 0 Q6PDB4 ZN880_HUMAN Zinc finger protein 880 ZNF880 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DFTRNSNLANHHR;IANNPGGR;ISLLARHQRIHTGEKPYK;VFNRNAHLAR 4 10.7 0.96104 -1.0591 0 0 0 0 8.46695 0 0 0 9.50797 0 9.11181 0 Q6PEV8 F199X_HUMAN Protein FAM199X FAM199X CXorf39 Homo sapiens (Human) EQRQARK;QLKEQRQAR 2 2.6 0.97182 -2.7011 0 0 0 0 0 0 0 0 0 9.35154 0 0 Q6PEW0 PRS54_HUMAN Inactive serine protease 54 (Cancer/testis antigen 67) (CT67) (Plasma kallikrein-like protein 4) PRSS54 KLKBL4 Homo sapiens (Human) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] DLDMCPLYKLQK;IFAGQNR 2 4.8 0.91068 -0.28482 0 0 0 0 6.81468 0 0 0 0 0 12.4437 0 Q6PEW1 ZCH12_HUMAN Zinc finger CCHC domain-containing protein 12 (Smad-interacting zinc finger protein 1) ZCCHC12 SIZN1 Homo sapiens (Human) nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] SESMVER 1 1.7 0.937 -0.54941 0 0 0 0 0 0 7.89682 0 0 0 0 0 Q6PEZ8 PONL1_HUMAN Podocan-like protein 1 PODNL1 SLRR5B Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201] VDTVDCDGLDLR;VPRGALSR 2 3.9 0.98057 -1.6113 14.3536 0 14.4493 0 0 0 0 0 0 0 12.4738 0 Q6PF15 KLH35_HUMAN Kelch-like protein 35 KLHL35 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EAGALRTRPRR;VAAAFSLAPLAER;VLQALNAYRR;VQCFDPK 4 7 0.97725 -2.2281 0 0 0 6.60764 0 0 0 0 0 0 0 10.0323 Q6PF15 KLH35_HUMAN Kelch-like protein 35 KLHL35 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EAGALRTRPRR;RHWAYPHAR;VAAAFSLAPLAER;VLQALNAYRR 4 9.8 0.74436 0.089673 0 0 0 0 0 0 0 5.45566 0 0 0 0 Q6PFW1 VIP1_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1 Homo sapiens (Human) inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647] cytosol [GO:0005829]; plasma membrane [GO:0005886] "5-diphosphoinositol pentakisphosphate 1-kinase activity [GO:0033857]; ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" QVSEFLSRVCQR 1 0.8 0.9651 -1.2166 0 0 0 0 0 0 0 0 0 0 8.70228 0 Q6PGP7 SKI3_HUMAN Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin) SKIC3 KIAA0372 TTC37 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087] ALEYFTCALQHRADVSCLWK;ISEAETLCTK;NLCLHLK;SLQLASQRGSWSGK;TLDQISDADNIPGLLVLK;YNHINAKDDLPGVYQK 6 5.4 0.97314 -1.3768 0 0 0 8.91919 7.72874 6.5909 9.76261 0 0 0 6.73132 0 Q6PGQ7 BORA_HUMAN Protein aurora borealis (HsBora) BORA C13orf34 Homo sapiens (Human) cell division [GO:0051301]; regulation of mitotic nuclear division [GO:0007088]; regulation of mitotic spindle organization [GO:0060236]; regulation of protein localization [GO:0032880] cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleus [GO:0005634] protein kinase binding [GO:0019901] DVEDKRQK;ESDAQTCEVESK 2 3.6 0.86351 -0.084656 0 12.4184 4.49653 0 0 0 0 0 0 0 0 11.118 Q6PHR2 ULK3_HUMAN Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular senescence [GO:0090398]; fibroblast activation [GO:0072537]; mitophagy [GO:0000423]; negative regulation of smoothened signaling pathway [GO:0045879]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; smoothened signaling pathway [GO:0007224] autophagosome [GO:0005776]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DQEGDSAAALSLYCK;LDGFILTER;LGSGTYATVYK 3 7.4 0.98199 -1.5863 0 0 0 0 0 0 11.1164 0 10.8127 0 0 0 Q6PHW0 IYD1_HUMAN Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1) IYD C6orf71 DEHAL1 Homo sapiens (Human) thyroid hormone metabolic process [GO:0042403]; tyrosine metabolic process [GO:0006570] cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] FMN binding [GO:0010181]; iodotyrosine deiodinase activity [GO:0140616]; oxidoreductase activity [GO:0016491] QVHGFAANGKKK 1 4.1 0.97766 -1.5217 0 0 0 0 0 0 0 0 11.1633 0 0 0 Q6PI26 SHQ1_HUMAN Protein SHQ1 homolog SHQ1 Homo sapiens (Human) box H/ACA snoRNP assembly [GO:0000493]; protein-RNA complex assembly [GO:0022618]; telomerase RNA localization to Cajal body [GO:0090671] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] unfolded protein binding [GO:0051082] DPDFTPAAER;LAAELAK 2 2.9 0.22432 0.31356 0 0 4.52607 0 9.28653 0 0 0 0 0 0 0 Q6PI47 KCD18_HUMAN BTB/POZ domain-containing protein KCTD18 KCTD18 Homo sapiens (Human) protein homooligomerization [GO:0051260] identical protein binding [GO:0042802] KAAQRSAPSR;KPTPQRVIKLK;QANSLKPLPGEAAR 3 8.2 0.81626 -0.017074 0 0 0 0 4.31687 0 0 5.27765 0 0 5.79462 0 Q6PI48 SYDM_HUMAN "Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" DARS2 Homo sapiens (Human) aspartyl-tRNA aminoacylation [GO:0006422]; mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145]; tRNA aminoacylation [GO:0043039] mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aspartate-tRNA ligase activity [GO:0004815]; aspartate-tRNA(Asn) ligase activity [GO:0050560]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] EYLCNLHGFVDIETPTLFK 1 2.9 0.78379 0.022441 0 0 0 0 0 0 6.80954 0 0 0 0 0 Q6PI77 GASP3_HUMAN G protein-coupled receptor associated sorting protein 3 (Protein BHLHb9) (bHLHb9) (Transcription regulator of 60 kDa) (p60TRP) GPRASP3 BHLHB9 KIAA1701 Homo sapiens (Human) learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neurogenesis [GO:0050769]; positive regulation of synapse assembly [GO:0051965] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803] MAGTKNK;MECYMDSEEFEK 2 3.5 0.89726 -0.25093 0 0 6.85587 0 0 0 9.03389 0 0 6.3265 0 0 Q6PI78 TMM65_HUMAN Transmembrane protein 65 TMEM65 Homo sapiens (Human) cardiac conduction [GO:0061337]; cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779] intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] GLLALAPPGGLPGGPR 1 6.7 0.78337 0.026449 0 3.49991 0 0 0 0 0 0 0 0 0 0 Q6PI97 HOATZ_HUMAN Cilia- and flagella-associated protein HOATZ HOATZ C11orf88 HOATZIN Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytoplasm [GO:0005737] IQAKTREEILQLLR 1 7.9 0.86895 -0.090719 0 0 0 0 0 0 0 7.28725 0 0 0 0 Q6PI98 IN80C_HUMAN INO80 complex subunit C (IES6 homolog) (hIes6) INO80C C18orf37 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654] YSDVSGLLANYTDPQSKLR 1 9.9 0.91616 -0.41678 0 0 0 0 0 0 0 0 0 5.26705 0 0 Q6PIF2 SYCE2_HUMAN Synaptonemal complex central element protein 2 (Central element synaptonemal complex protein 1) SYCE2 CESC1 Homo sapiens (Human) cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] ISHLETELKQVCHSVETVYK;SRQKDHALMTNFR;WGPDHSRGK 3 19.3 0.97944 -1.893 0 0 0 0 7.89603 0 0 8.35235 0 0 0 0 Q6PIF6 MYO7B_HUMAN Unconventional myosin-VIIb MYO7B Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; endocytosis [GO:0006897]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; apical cytoplasm [GO:0090651]; brush border [GO:0005903]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AGNHLFK;ARGHLWAYSCEPLRQPLLK;ICHKIYFPNDTSEMLEVVANTR;INAAIFTPPAQDPK;IYFPNDTSEMLEVVANTR;KSGFPIRYTFEEFSQR;LLAPDCSR;LLEVQHQELR;LMSSEEWKK;LNSVHANNKAFLQPK 10 5.7 0.9793 -1.8943 6.41243 0 0 0 11.4528 10.0791 11.1021 0 0 11.7178 10.245 0 Q6PIF6 MYO7B_HUMAN Unconventional myosin-VIIb MYO7B Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; endocytosis [GO:0006897]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; apical cytoplasm [GO:0090651]; brush border [GO:0005903]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AGNHLFK;ARGHLWAYSCEPLRQPLLK;ICHKIYFPNDTSEMLEVVANTR;INAAIFTPPAQDPK;IYFPNDTSEMLEVVANTR;KPPNFPVPSPSPGHQPEGGRLLL;KSGFPIRYTFEEFSQR;LLAPDCSR;LLEVQHQELR;LNSVHANNKAFLQPK 10 6.8 0.8339 -0.029624 0 0 0 0 0 0 0 0 0 0 9.19508 0 Q6PII3 CC174_HUMAN Coiled-coil domain-containing protein 174 CCDC174 C3orf19 Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] DTKPGVPHIREWDR 1 3 0.89187 -0.21352 0 0 0 0 0 0 0 0 0 0 7.75054 0 Q6PII5 HAGHL_HUMAN Hydroxyacylglutathione hydrolase-like protein (EC 3.1.2.-) HAGHL Homo sapiens (Human) hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] AKLSWAK;GMRMTCPLCRR 2 6.2 0.76816 0.059674 0 0 0 0 0 0 0 0 0 0 0 9.44298 Q6PII5 HAGHL_HUMAN Hydroxyacylglutathione hydrolase-like protein (EC 3.1.2.-) HAGHL Homo sapiens (Human) hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] AKLSWAK;VAEEPVRK 2 5.3 0.9803 -1.7142 0 0 0 9.04887 0 8.28249 8.82668 0 0 0 0 11.3439 Q6PIJ6 FBX38_HUMAN F-box only protein 38 FBXO38 SP329 Homo sapiens (Human) adaptive immune response [GO:0002250]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein K48-linked ubiquitination [GO:0070936]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] CCCHRPQESQR;EEKTGESVQSR;KYPKYPWGR;YGLADVVENPGIITDIGMK 4 4.2 0.97243 -2.7572 0 9.36903 0 0 0 0 0 0 0 0 0 11.4761 Q6PIL6 KCIP4_HUMAN Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4) KCNIP4 CALP KCHIP4 Homo sapiens (Human) protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459] GLSILLRGTVQEK;LLPCSAAK;QHVETFFQKMDKNK 3 14 0.97663 -2.2441 0 0 0 6.61834 12.6337 12.7351 0 12.3075 12.2587 0 12.1519 13.035 Q6PIU1 KCNV1_HUMAN Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel alpha subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1) KCNV1 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] intercellular bridge [GO:0045171]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] DTEDQESQHESEQDFSQGPCPTVR 1 4.8 0.80777 0.0084121 0 0 9.66706 0 0 0 0 0 0 0 0 0 Q6PIU2 NCEH1_HUMAN Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) NCEH1 AADACL1 KIAA1363 Homo sapiens (Human) ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle clearance [GO:0034383]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771] SAPLIADQAVLQLLPK 1 3.9 0.004902 1.6083 0 0 0 0 0 0 8.07098 6.39391 0 0 0 0 Q6PIV2 FOXR1_HUMAN Forkhead box protein R1 (Forkhead box protein N5) FOXR1 FOXN5 DLNB13 Homo sapiens (Human) brain development [GO:0007420]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]" IVKPPKLPLEK;LRIVKPPKLPLEK;LTEEGHRR 3 7.2 0.93677 -0.55157 0 0 0 3.95838 9.77469 0 0 0 2.6259 0 0 0 Q6PIW4 FIGL1_HUMAN Fidgetin-like protein 1 (EC 3.6.4.-) FIGNL1 Homo sapiens (Human) ATP metabolic process [GO:0046034]; cellular response to ionizing radiation [GO:0071479]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; microtubule severing ATPase activity [GO:0008568] ASGSSYGGVKKSLGASR;MMQAGKK 2 3.6 0.96388 -1.2001 12.6041 0 0 0 0 0 0 0 0 0 0 0 Q6PIY5 ARMD1_HUMAN Armadillo-like helical domain containing protein 1 (p40) ARMH1 C1orf228 NCRNA00082 Homo sapiens (Human) AIGVLARNDMSIAEELLYLRVVR;GLVALLIPSVKEISKLQAK 2 9.5 0.74617 0.094081 0 8.34021 0 0 0 4.16197 0 0 0 0 3.22549 0 Q6PIY7 GLD2_HUMAN Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) TENT2 GLD2 PAPD4 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; histone mRNA catabolic process [GO:0071044]; mRNA 3'-end processing [GO:0031124]; negative regulation of miRNA catabolic process [GO:2000626]; target-directed miRNA degradation [GO:0140958] cytoplasm [GO:0005737]; nuclear RNA-directed RNA polymerase complex [GO:0031380] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817] DQFLKSWHR;ELCRTQLQR;LSDEKNLPLDGKR;NLPLDGK;QKFDMIKDQFLK 5 7.9 0.97697 -2.2237 13.0892 0 11.6307 0 0 0 0 12.2192 0 0 0 0 Q6PJ61 FBX46_HUMAN F-box only protein 46 (F-box only protein 34-like) FBXO46 FBX46 FBXO34L Homo sapiens (Human) FKIQRLLEPR;LLEPRQYMLLLPEHVLVK;SYWMCCRR;VKGHWGSDSSK 4 7 0.97307 -2.8628 0 0 0 9.7658 0 0 9.02824 6.58301 0 0 0 0 Q6PJ69 TRI65_HUMAN E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) TRIM65 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; negative regulation of inflammatory response [GO:0050728]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein oligomerization [GO:0032461]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] HGRPLELFCRTEGR;LWQNYRNLTFDPVSANRHFYLSR 2 7.2 0.9026 -0.26351 0 0 0 0 0 0 8.47699 0 0 0 0 7.61662 Q6PJF5 RHDF2_HUMAN Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) RHBDF2 IRHOM2 RHBDL5 RHBDL6 Homo sapiens (Human) negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of protein secretion [GO:0050709]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708] endoplasmic reticulum membrane [GO:0005789]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] growth factor binding [GO:0019838]; protein transporter activity [GO:0140318] DLELPSQEAPSFQGTESPKPCKMPK;FSPCIRK;GVYESVK;KDGQIEQLVLR;KRHYGLGVVGNWLNR;RTSGAVCHQDPR;SVLDATGQR 7 9.9 0.97478 -2.3996 10.6862 0 0 0 0 9.62286 0 9.05932 9.3836 5.07626 7.36405 10.524 Q6PJG2 MDEAS_HUMAN Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) MIDEAS C14orf117 C14orf43 ELMSAN1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] ADLVWQPWEDLESSR;AVSTGDCGQVLR 2 2.6 0.95931 -1.038 0 0 0 0 0 0 12.872 9.76185 0 9.89833 0 0 Q6PJG6 BRAT1_HUMAN BRCA1-associated ATM activator 1 (BRCA1-associated protein required for ATM activation protein 1) BRAT1 BAAT1 C7orf27 Homo sapiens (Human) apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; glucose metabolic process [GO:0006006]; mitochondrion localization [GO:0051646]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; response to ionizing radiation [GO:0010212] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RLCHPCWEVR 1 1.2 0.65333 0.17003 0 0 0 0 0 0 0 0 0 0 8.23165 0 Q6PJG9 LRFN4_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 4 LRFN4 SALM3 Homo sapiens (Human) regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] NAITRIGAR;RSHSVHGGLLGAGCR;SHSVHGGLLGAGCRGVGGSAER 3 5 0.98084 -1.6079 0 0 12.2858 0 0 0 0 0 0 9.23886 0 0 Q6PJI9 WDR59_HUMAN GATOR2 complex protein WDR59 (WD repeat-containing protein 59) WDR59 KIAA1923 FP977 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Seh1-associated complex [GO:0035859]; vacuolar membrane [GO:0005774] metal ion binding [GO:0046872]; signaling adaptor activity [GO:0035591] DQTLRMWRVDSQMQR;SDPDLETPWARHPFGR 2 3.2 0.95254 -0.74925 0 0 0 0 6.5612 0 0 0 8.9578 0 0 0 Q6PJP8 DCR1A_HUMAN DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) DCLRE1A KIAA0086 SNM1 SNM1A Homo sapiens (Human) cell division [GO:0051301]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] 5'-3' DNA exonuclease activity [GO:0035312]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872] KRHGPLLK;NNTNSACFCR;SAHGGLQR 3 2.5 0.97806 -2.1526 7.66306 0 0 0 6.78568 5.00984 0 0 0 0 0 0 Q6PJQ5 FOXR2_HUMAN Forkhead box protein R2 (Forkhead box protein N6) FOXR2 FOXN6 Homo sapiens (Human) chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" DEDNARPRSCLWKLTK;DEGSNCSEDK;VVESLPSSSSEQSPLQK 3 13.8 0.83679 -0.03068 0 4.78649 0 10.0591 0 10.2201 0 0 12.8752 5.76742 0 0 Q6PJT7 ZC3HE_HUMAN Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) ZC3H14 Homo sapiens (Human) regulation of mRNA stability [GO:0043488] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723] KFNHDGEEEEEDDDYGSR;LLERCKYWPACK 2 4.1 0.74893 0.078373 0 0 0 0 0 9.7525 0 0 0 10.6511 0 0 Q6PJW8 CNST_HUMAN Consortin CNST C1orf71 Homo sapiens (Human) positive regulation of Golgi to plasma membrane protein transport [GO:0042998] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] connexin binding [GO:0071253]; phosphatase binding [GO:0019902] IAAVEKSQERK 1 1.5 0.76502 0.063494 0 0 0 0 0 0 0 0 0 0 0 10.6082 Q6PK04 CC137_HUMAN Coiled-coil domain-containing protein 137 CCDC137 cPERP-B Homo sapiens (Human) chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634] RNA binding [GO:0003723] KKVNCKPK;QPEVQAAPK 2 5.9 0.98099 -1.791 9.86723 0 0 0 0 0 0 0 0 0 9.77706 0 Q6PK18 OGFD3_HUMAN 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC 1.14.11.-) OGFOD3 C17orf101 Homo sapiens (Human) membrane [GO:0016020] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FEGCTPRKCGR;GVTDVVITREEAER;INSTEARTAHDEYWHAHVDK;TVEPRAGCFCFR 4 17.2 0.97472 -3.1069 0 0 0 5.37062 8.30647 0 0 0 0 0 7.2034 0 Q6PK81 ZN773_HUMAN Zinc finger protein 773 (Zinc finger protein 419B) ZNF773 ZNF419B Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLLTSSGVLKHQVTHTGEKSHR;IHTGEIQ;MAAATLR 3 8.1 0.95523 -0.94457 10.9506 0 0 0 0 8.55144 0 0 0 6.10471 0 0 Q6PKC3 TXD11_HUMAN Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1) TXNDC11 EFP1 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] DSEVVLLFFYAPWCGQSIAAR;EVLNYTAENICKWALENQETLFR;LLQHLRR;SPVLDLFQGQLDYAEYVRR 4 7.1 0.92908 -0.48182 9.95723 0 0 0 10.0802 9.06878 11.7017 0 0 12.3858 0 10.0965 Q6PKH6 DR4L2_HUMAN Dehydrogenase/reductase SDR family member 4-like 2 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 25C member 3) (Protein SDR25C3) DHRS4L2 SDR25C3 Homo sapiens (Human) retinal metabolic process [GO:0042574] extracellular region [GO:0005576]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] carbonyl reductase (NADPH) activity [GO:0004090] LLGLCAWARK;LVAMAVK;MQMARLLGLCAWARK 3 9.5 0.94248 -0.61591 8.96107 0 0 0 7.91289 0 0 0 0 0 12.0519 0 Q6PKX4 DOK6_HUMAN Docking protein 6 (Downstream of tyrosine kinase 6) DOK6 DOK5L Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; cytosol [GO:0005829] GPRRLEK;TFACESELEAEEWCK;VTELHNIKNITR 3 10.3 0.87413 -0.10743 0 0 7.50978 0 6.76208 7.9982 0 0 0 8.35913 0 0 Q6PL18 ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) ATAD2 L16 PRO2000 Homo sapiens (Human) nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation-coupled chromatin remodeling [GO:0045815] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; histone binding [GO:0042393] DAQNSSDSSFEK;DYGEIFNVQLPDK;EVETYHR;GCSSSKYAPSYYHVMPK;KPAATTAKAGDGSSVK;KPNIFYSGPASPARPRYR;LDSIDPALR;LIRHRACALR;YAPSYYHVMPKQNSTLVGDK 9 8 0.97836 -1.9821 11.8015 8.87698 9.58956 0 0 0 11.6943 0 0 0 10.18 6.83453 Q6PL18 ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) ATAD2 L16 PRO2000 Homo sapiens (Human) nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation-coupled chromatin remodeling [GO:0045815] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; histone binding [GO:0042393] KPNIFYSGPASPARPRYR;QDQIHSSYGWIGQQR 2 8 0.78406 0.023524 0 0 0 0 0 0 0 0 0 0 2.49562 0 Q6PL24 TMED8_HUMAN Protein TMED8 TMED8 FAM15B L10 Homo sapiens (Human) GSRSSLR;VPTHPEGK 2 4.6 0.97831 -1.9245 0 0 11.2617 0 0 0 0 11.3116 0 0 10.3075 0 Q6PML9 ZNT9_HUMAN "Proton-coupled zinc antiporter SLC30A9, mitochondrial (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) (Zinc transporter 9) (ZnT-9)" SLC30A9 C4orf1 HUEL Homo sapiens (Human) intracellular zinc ion homeostasis [GO:0006882]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrion organization [GO:0010821]; zinc ion transport [GO:0006829] cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] antiporter activity [GO:0015297]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; zinc ion transmembrane transporter activity [GO:0005385] AKGMSFYK;SIQPEQVQR 2 3 0.98092 -1.6077 10.9635 0 0 0 0 0 0 9.78065 0 0 0 0 Q6PP77 XKR2_HUMAN "XK-related protein 2 (Membrane protein XPLAC) (X Kell blood group-related, X-linked)" XKRX XKR2 XPLAC XRG2 Homo sapiens (Human) plasma membrane [GO:0005886] LLILVLFSATLKLK;TLEITSRLLILVLFSATLK;YLTLWKK 3 6.2 0.92225 -0.44321 0 10.4005 4.687 0 3.28636 0 9.28914 0 9.46793 0 0 0 Q6PRD1 GP179_HUMAN Probable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like) GPR179 GPR158L GPR158L1 Homo sapiens (Human) visual perception [GO:0007601] dendrite [GO:0030425]; postsynaptic membrane [GO:0045211] G protein-coupled receptor activity [GO:0004930] ESPAQAPK;GVPVQKKPEMADFR;LLGFAIVYGTIILKLYR;LLGFAIVYGTIILKLYRVLQLFLSR;RPSARRLERPR;SLSVASSREK;STYDQRR;VSADLGPRER 8 3.6 0.97504 -4.1889 0 8.5359 12.4097 10.5097 0 9.1692 11.4446 0 9.38202 8.41945 11.098 9.45189 Q6PRD7 CEMP1_HUMAN Cementoblastoma-derived protein 1 (Cementum protein 1) (Cementum protein 23) (CP-23) CEMP1 Homo sapiens (Human) biomineral tissue development [GO:0031214]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; odontogenesis [GO:0042476] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] hydroxyapatite binding [GO:0046848] RAPEAHPPR 1 3.6 0.91769 -0.40844 0 0 0 0 0 0 0 0 10.3596 0 0 0 Q6Q0C0 TRAF7_HUMAN E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein K29-linked ubiquitination [GO:0035519]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] SLELKFDVLDENQSK;TIKVWDTCTTYK;VWDTCTTYKCQK 3 4.5 0.96366 -1.0929 0 0 0 0 9.00152 0 0 0 0 0 11.4969 0 Q6Q0C1 S2547_HUMAN Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein) (Mitochondrial NAD(+) transporter SLC25A47) SLC25A47 C14orf68 HDMCP HMFN1655 Homo sapiens (Human) mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] acetyl-CoA transmembrane transporter activity [GO:0008521]; NAD transmembrane transporter activity [GO:0051724]; transmembrane transporter activity [GO:0022857] GPLHCLATVAREEGLCGLYK;LQTQTQAQK 2 9.4 0.94403 -0.63082 17.9368 0 17.9153 14.4892 14.4513 0 0 0 8.0018 0 0 0 Q6Q4G3 AMPQ_HUMAN Aminopeptidase Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2 antigen) (Laeverin) LVRN AQPEP Homo sapiens (Human) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] DLEAESSPPLR;DLVSEVNIYDIYSLLKRYLLK;LGQSEKEDVNGSK;LLLHSLFQDCER 4 5.8 0.96266 -1.0805 0 0 0 0 0 8.85842 0 0 0 7.23601 8.81481 0 Q6Q759 SPG17_HUMAN Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; microtubule [GO:0005874]; motile cilium [GO:0031514] ADSHEKKPK;EEAIYQESKMNEK;EIETTQNYLMDIKNR;ELKTFWK;FQLLQIKFK;LTLPLIGKLLK;SPSVLQMR;TQQRSLMDWSFTEHFKPK;TVTRQVK;VIEDKPKLEK 10 4.8 0.97828 -8.6196 12.9003 0 13.7378 0 0 6.20639 0 3.45101 10.9251 11.7796 0 11.4634 Q6Q788 APOA5_HUMAN Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3) APOA5 RAP3 UNQ411/PRO773 Homo sapiens (Human) acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; tissue regeneration [GO:0042246]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle remodeling [GO:0034370] chylomicron [GO:0042627]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; late endosome [GO:0005770]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; lipase activator activity [GO:0060229]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] VEQIHQQK 1 2.2 0.91442 -0.39033 0 0 0 0 0 0 0 12.4958 0 0 0 0 Q6QHC5 DEGS2_HUMAN Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (EC 1.14.18.5) (EC 1.14.19.17) (Degenerative spermatocyte homolog 2) (Sphingolipid 4-desaturase) (Sphingolipid C4-monooxygenase) DEGS2 C14orf66 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; sphinganine metabolic process [GO:0006667]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] sphingolipid C4-monooxygenase activity [GO:0102772]; sphingolipid delta-4 desaturase activity [GO:0042284]; sphingosine hydroxylase activity [GO:0000170] KLLWLVLQPFFYSLRPLCVHPK;SDFEWVYTDQPHTQR;VLWDFVFEDSLGPYAR 3 16.4 0.93724 -0.5676 0 0 0 0 0 8.63118 0 0 4.77637 0 0 0 Q6QHF9 PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO UNQ1923/PRO4398 Homo sapiens (Human) polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208] cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity [GO:0052903]; polyamine oxidase activity [GO:0046592] EHLDTFFDPPLPAEK;EIGQHVAGWTEDEETRK;VTGNPRLPAPKSVLR 3 9.2 0.91329 -0.38477 0 0 0 0 0 0 0 0 0 0 9.81202 10.689 Q6QHF9 PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO UNQ1923/PRO4398 Homo sapiens (Human) polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208] cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity [GO:0052903]; polyamine oxidase activity [GO:0046592] SERCFGAIK 1 13 0.90165 -0.26276 0 0 0 0 0 0 0 10.6237 0 0 0 0 Q6QNK2 AGRD1_HUMAN Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) ADGRD1 GPR133 PGR25 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LSPWDKSSHSAHR;SSHSAHR 2 1.5 0.95806 -1.0031 0 9.86916 9.15081 0 0 0 0 0 0 0 0 0 Q6QNY0 BL1S3_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) BLOC1S3 BLOS3 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytosol [GO:0005829]; transport vesicle [GO:0030133] protein transmembrane transporter activity [GO:0008320] GVPGTEPEKDPGPR 1 6.9 0.92166 -0.44558 0 0 9.00481 0 0 0 0 0 0 0 0 0 Q6QNY1 BL1S2_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein) BLOC1S2 BLOS2 CEAP Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; platelet dense granule organization [GO:0060155]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; centrosome [GO:0005813]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634] gamma-tubulin binding [GO:0043015] YLEMKDIAINISRNLK 1 11.3 0.43215 0.19507 0 0 0 0 0 0 0 0 10.8331 0 0 0 Q6R2W3 SCND3_HUMAN SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9) SCAND3 Buster4 KIAA1925 ZBED9 ZNF305P2 ZNF452 Homo sapiens (Human) DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679] cytoplasm [GO:0005737]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] DNLNLTVTLQDK;EEDHTWDQESALR;LIEAVNGETDK;VALPVAKSKTPYTIAETLVK 4 4.2 0.97511 -1.4442 2.33634 0 0 0 0 0 11.5943 0 5.04308 9.2248 0 8.48917 Q6R327 RICTR_HUMAN Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) RICTOR KIAA1999 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; lipid biosynthetic process [GO:0008610]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; TORC2 signaling [GO:0038203] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932] ATP binding [GO:0005524]; enzyme-substrate adaptor activity [GO:0140767]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; ribosome binding [GO:0043022]; zinc ion binding [GO:0008270] DKNSFPFFASSKLVK;EARFLASK;ILAPYTDFHYR;LGFHYEDIIICLR;LYANLDLDFAKAK;MHPSLSHSEALASPAKDVLFTDTITMK;MLEKCSVFQCLLNLCSLK;NLRVRGR;TIPDDTPMCR;TISSEALDILDEACEDK;VLKLKVDYLIAR 11 8.8 0.97567 -3.3188 0 6.13467 8.48289 0 10.279 8.53423 0 0 10.9313 7.6125 0 3.83491 Q6RFH5 WDR74_HUMAN WD repeat-containing protein 74 (NOP seven-associated protein 1) WDR74 NSA1 Homo sapiens (Human) blastocyst formation [GO:0001825]; ribosomal large subunit biogenesis [GO:0042273]; RNA metabolic process [GO:0016070]; rRNA processing [GO:0006364] "nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]" LSGLEQPQGALQTR 1 3.6 0.87522 -0.12015 0 0 0 0 0 0 11.1124 0 0 0 0 0 Q6RFH8 DUX4C_HUMAN "Double homeobox protein 4C (Double homeobox protein 4, centromeric) (DUX4c) (Double homeobox protein 4-like protein 9)" DUX4L9 DUX4C Homo sapiens (Human) cell population proliferation [GO:0008283]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" ALPTPSDSTLPAEAR 1 4 0.78115 0.032404 0 0 0 0 0 0 0 0 0 0 10.363 0 Q6RI45 BRWD3_HUMAN Bromodomain and WD repeat-containing protein 3 BRWD3 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] AYTSNKK;EPRTGIKR;GTGGRGRWGR;LINEGDVPHLPVNR;MFITTGSTDHVIR;NIISEYKSAIQSQKR;RQTRQTTR;SLEERQK;VQEECRTAK 9 6.2 0.97811 -6.2694 0 7.83213 0 0 5.94781 10.8985 0 9.06606 0 11.5824 10.7455 10.7796 Q6RW13 ATRAP_HUMAN Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) AGTRAP ATRAP Homo sapiens (Human) regulation of blood pressure [GO:0008217]; response to hypoxia [GO:0001666] cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] angiotensin type II receptor activity [GO:0004945]; identical protein binding [GO:0042802] SQDARGY 1 4.4 0.90537 -0.2711 0 0 0 0 0 0 0 0 6.66007 0 0 0 Q6S545 POTEH_HUMAN "POTE ankyrin domain family member H (ANKRD26-like family C member 3) (Prostate, ovary, testis-expressed protein on chromosome 22) (POTE-22)" POTEH A26C3 ACTBL1 POTE22 Homo sapiens (Human) KDLIVMLK;WCCHCFPCCR;WCCHCFPCCRGSGK;WCCHCFPWCR 4 8.4 0.74601 0.10219 0 0 0 0 0 9.29004 0 5.88616 5.06044 0 0 6.31604 Q6S5L8 SHC4_HUMAN SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) SHC4 SHCD UNQ6438/PRO21364 Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]; positive regulation of cell population proliferation [GO:0008284]; regulation of gene expression [GO:0010468]; stem cell differentiation [GO:0048863] plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971] AIGNVHPR;LCEAVPGANGAIKK;SLDFGMR 3 4.6 0.94162 -0.60558 0 0 8.68363 9.10058 4.64363 0 0 9.5308 0 0 0 0 Q6S5L8 SHC4_HUMAN SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) SHC4 SHCD UNQ6438/PRO21364 Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]; positive regulation of cell population proliferation [GO:0008284]; regulation of gene expression [GO:0010468]; stem cell differentiation [GO:0048863] plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971] AIGNVHPR;LPALEHWIPKFFSFR 2 5.9 0.88317 -0.17398 0 0 0 5.55001 0 0 0 0 0 0 0 0 Q6S8J3 POTEE_HUMAN "POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2)" POTEE A26C1A POTE2 Homo sapiens (Human) axonogenesis [GO:0007409]; cell motility [GO:0048870]; substantia nigra development [GO:0021762] actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202] protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] AGFAGDDAPR;AVFPSIVGRPR;DLIVMLRDTDVNKK;FTTMAER;LCYVALDFEQEMATAASSSSLEK;LDLAGRELPDYLMK;LELDTMK;QEYDESGPSIVHR;SYELPDGQVITIGNER;WCCHCFPCCR;WCCHCFPCCRGSGK;WCHHCFPCCR 12 12.9 0.97563 -3.4061 12.4034 12.8846 0 0 0 0 7.24584 0 0 7.52724 4.33785 0 Q6S8J7 POTEA_HUMAN "POTE ankyrin domain family member A (ANKRD26-like family A member 1) (Prostate, ovary, testis-expressed protein on chromosome 8) (POTE-8)" POTEA A26A1 POTE8 Homo sapiens (Human) LAASPMK;VAEVSPK;VTQEPDINK;WCCCCFPCCR;WCCCCFPCCRGSGK 5 7.4 0.96901 -1.3304 0 0 5.58295 5.375 0 5.49128 9.24317 10.1731 0 3.28204 10.5117 5.41853 Q6S9Z5 ZN474_HUMAN Zinc finger protein 474 (Testis-specific zinc finger protein) (TSZFP) ZNF474 Homo sapiens (Human) metal ion binding [GO:0046872] EYTNSKQQR 1 2.5 0.96379 -1.0945 0 0 0 11.0705 0 0 0 11.1621 0 11.6172 11.4881 0 Q6SA08 TSSK4_HUMAN Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) (Serine/threonine-protein kinase 22E) TSSK4 C14orf20 STK22E TSSK5 Homo sapiens (Human) fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; positive regulation of CREB transcription factor activity [GO:0032793]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VLRHKYLINFYR 1 3.7 0.86634 -0.091826 0 0 0 0 0 11.6354 0 0 0 0 11.1198 13.0482 Q6SJ93 F111B_HUMAN Serine protease FAM111B (EC 3.4.21.-) (Cancer-associated nucleoprotein) FAM111B CANP Homo sapiens (Human) DNA replication [GO:0006260]; proteolysis [GO:0006508] chromatin [GO:0000785]; nucleus [GO:0005634] peptidase activity [GO:0008233] EEQKRMNLSPAK;GETIEGALCKDGRFR;NIIVYEEKTIDGHINLGMPLK;SLNDEKLETYDEEK 4 8.4 0.98076 -1.6323 0 0 0 9.95099 0 0 0 0 9.21861 5.16816 0 6.48377 Q6SJ96 TBPL2_HUMAN TATA box-binding protein-like 2 (TBP-like 2) (TATA box-binding protein-related factor 3) (TBP-related factor 3) TBPL2 TBP2 TRF3 Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352] cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251] IVLLIFVSGKVVLTGAK;IVLLIFVSGKVVLTGAKER 2 5.5 0.80767 0.0074171 0 0 0 0 0 0 2.54575 6.91695 0 0 7.45426 0 Q6STE5 SMRD3_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C) SMARCD3 BAF60C Homo sapiens (Human) cardiac right ventricle formation [GO:0003219]; chromatin remodeling [GO:0006338]; muscle cell differentiation [GO:0042692]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary heart field specification [GO:0003139] brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221] DPKGYVQDLLRSQSR;LDQTIMRK;LLDDPSK 3 6.2 0.77843 0.038404 0 0 0 7.75462 8.13437 8.31637 4.10047 0 0 9.81178 0 11.0834 Q6SZW1 SARM1_HUMAN NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) SARM1 KIAA0524 SAMD2 SARM Homo sapiens (Human) cell differentiation [GO:0030154]; innate immune response [GO:0045087]; modification of postsynaptic structure [GO:0099010]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; protein localization to mitochondrion [GO:0070585]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; regulation of synapse pruning [GO:1905806]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; signal transduction [GO:0007165] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of synaptic membrane [GO:0099243]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; protein-containing complex [GO:0032991]; synapse [GO:0045202] "identical protein binding [GO:0042802]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; NADP+ nucleosidase activity [GO:0050135]; signaling adaptor activity [GO:0035591]" LEAGKFEDK;TDPALLR 2 2.2 0.93783 -0.57557 0 12.1655 0 0 0 0 0 0 0 0 9.8653 0 Q6T423 S22AP_HUMAN Solute carrier family 22 member 25 (Organic anion transporter UST6) SLC22A25 UST6 Homo sapiens (Human) organic anion transport [GO:0015711] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] QELEAAQKKHSLCELLR 1 3.1 0.48206 0.19024 0 7.01413 0 0 0 0 10.3171 0 0 0 0 0 Q6T4R5 NHS_HUMAN Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) NHS Homo sapiens (Human) cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear body [GO:0016604] GGDAEPK;HFLTFNSTR;LSVYYRAPWHQQR;NAAVSNLDIESK;SVNLRSINK;TISGIPRR;VPERKSSLQQPSLK 7 4.9 0.98005 -1.6528 9.00203 0 8.23965 9.33909 0 9.39823 0 0 8.81996 11.6915 0 0 Q6TCH4 PAQR6_HUMAN Membrane progestin receptor delta (mPR delta) (Membrane progesterone P4 receptor delta) (Membrane progesterone receptor delta) (Progesterone and adipoQ receptor family member 6) (Progestin and adipoQ receptor family member 6) PAQR6 Homo sapiens (Human) plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; steroid binding [GO:0005496] LSLKLPQLLQVHQVPR 1 4.7 0.91827 -0.43518 0 0 0 3.0905 0 0 0 0 0 0 0 0 Q6TCH4 PAQR6_HUMAN Membrane progestin receptor delta (mPR delta) (Membrane progesterone P4 receptor delta) (Membrane progesterone receptor delta) (Progesterone and adipoQ receptor family member 6) (Progestin and adipoQ receptor family member 6) PAQR6 Homo sapiens (Human) plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; steroid binding [GO:0005496] GHRREGR 1 2 0.82877 -0.023273 0 0 0 0 0 0 0 0 0 8.60748 0 0 Q6TDP4 KLH17_HUMAN Kelch-like protein 17 (Actinfilin) KLHL17 AF Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252] actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; POZ domain binding [GO:0031208]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] YEPQVNVWSPVASMLSR;YNPRTNKWVAASCMFTR 2 5.3 0.39754 0.21116 0 0 0 8.58357 8.01553 0 0 0 0 0 0 0 Q6TDU7 DNAI7_HUMAN Dynein axonemal intermediate chain 7 (Cancer susceptibility candidate gene 1 protein) (Protein CASC1) (Cilia and flagella associated protein 94) (Lung adenoma susceptibility 1-like protein) (Protein phosphatase 1 regulatory subunit 54) DNAI7 CASC1 CFAP94 LAS1 PPP1R54 Homo sapiens (Human) axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cilium [GO:0005929] beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017] LLQEEEER;MSGSKKK;VEEEQGDIEVK;WHRLEAK 4 4.6 0.97511 -3.3758 13.4652 0 0 0 9.50126 0 12.8887 0 0 7.09645 0 0 Q6TFL3 CC171_HUMAN Coiled-coil domain-containing protein 171 CCDC171 C9orf93 Homo sapiens (Human) CADREALISTLK;DLEGALQVEK;FEHDLEER;FESACEELNNALLR;IASLDVK;LEKTLQEALEK;LSQAFHK;QILKNETELDITDNLR;SITYVEKDSLVQR 9 7.4 0.97489 -3.7051 0 11.6015 0 0 11.6668 5.91901 9.97528 0 9.5915 11.596 10.1233 9.64128 Q6TFL4 KLH24_HUMAN Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AVLSACSSYFR;TLFTKCK;VASLNKGR 3 4.3 0.95571 -0.84225 0 0 0 0 0 0 9.60916 0 0 7.56354 0 10.8416 Q6TGC4 PADI6_HUMAN Inactive protein-arginine deiminase type-6 (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI) (Protein-arginine deiminase type-6) PADI6 PAD6 Homo sapiens (Human) cytoplasm organization [GO:0007028]; cytoskeleton organization [GO:0007010]; embryonic cleavage [GO:0040016]; regulation of translation by machinery localization [GO:0043143] cortical granule [GO:0060473]; cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668] AMSKTLR;DILKTELGLVEQDIIEIPQLFCLEKLTNIPSDQQPK;LVLHTSKEESKK 3 7.9 0.97283 -2.6643 0 0 0 0 0 0 11.2074 11.2095 12.3584 0 0 0 Q6U7Q0 ZN322_HUMAN Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) ZNF322 ZNF322A ZNF388 ZNF489 Homo sapiens (Human) positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CLECMRSFTR;QNFCENLALIMCER 2 6 0.83663 -0.033559 0 0 0 6.5277 0 0 0 0 0 0 8.27286 0 Q6U841 S4A10_HUMAN Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) SLC4A10 NBCN2 NCBE Homo sapiens (Human) bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; chloride transport [GO:0006821]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; proton transmembrane transport [GO:1902600]; pyramidal neuron development [GO:0021860]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to light stimulus [GO:0009416]; transmembrane transport [GO:0055085]; visual perception [GO:0007601] apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202] "sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]" NLLITADNSK;TVVAFVR 2 1.5 0.95482 -0.96498 0 0 0 0 0 0 0 0 0 0 0 9.78787 Q6U949 IG2AS_HUMAN Putative insulin-like growth factor 2 antisense gene protein (IGF2 antisense RNA 1) (IGF2 antisense gene protein 1) (PEG8/IGF2AS protein) (Putative insulin-like growth factor 2 antisense gene protein 1) (IGF2-AS1) IGF2-AS IGF2-AS1 IGF2AS Homo sapiens (Human) QPGRPGK 1 4.2 0.91284 -0.32188 0 0 0 0 0 0 0 0 0 7.08151 0 0 Q6UB28 MAP12_HUMAN "Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)" METAP1D MAP1D Homo sapiens (Human) N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; proteolysis [GO:0006508] mitochondrion [GO:0005739] aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235] GAQILTK 1 2.1 0.60195 0.1782 0 0 0 0 0 0 0 0 0 10.6121 0 0 Q6UB35 C1TM_HUMAN "Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)" MTHFD1L FTHFSDC1 Homo sapiens (Human) 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; neural tube closure [GO:0001843]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; protein homodimerization activity [GO:0042803] DVDGVTDINLGK;ITIGQGNTEK;LGRMVVASDK;TIAQAVYGAK 4 4.3 0.97869 -2.1096 0 11.3245 0 0 0 0 0 0 0 0 9.90415 0 Q6UB98 ANR12_HUMAN Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] DEPLKTPDGK;DKIASYSKTPK;EGKTLKK;KTPSSSSRQK;LPFTISPSRNEERDSDTEK;NVMTLGK;TDAFVPVYSDSTIQEASPNFEK;TPLPSALDEYEFKDDDDEEINK;VELEENAEDDKTENQIPQR 9 6.2 0.97546 -3.5669 0 0 9.64142 6.97327 0 10.0837 0 9.34379 0 0 10.916 12.6533 Q6UB99 ANR11_HUMAN Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) ANKRD11 ANCO1 Homo sapiens (Human) face morphogenesis [GO:0060325]; odontogenesis of dentin-containing tooth [GO:0042475]; skeletal system morphogenesis [GO:0048705] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DRWFSDLSDSSFDFK;DSRAREK;EKFKDGAEK;EPFFRKK;GLEPWERHHPAREK;HADGLLR;LHIPVIAPPPSLAEPLKELFR;LPFTAGANGEQKDSDTEK;SFREEKDR;SFTYEYEDSKQKSDK;YDRMKTCLLMR 11 5 0.97814 -7.8387 0 11.5959 0 13.0079 7.44386 11.1833 11.91 12.0733 12.1989 12.0564 12.3708 11.6249 Q6UDR6 SPIT4_HUMAN Kunitz-type protease inhibitor 4 SPINT4 C20orf137 Homo sapiens (Human) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] IAEKICGDLKDPCK 1 14.1 0.86641 -0.090561 0 0 0 0 0 7.60555 0 0 0 0 0 0 Q6UE05 TM270_HUMAN Transmembrane protein 270 (Williams-Beuren syndrome chromosomal region 28 protein) TMEM270 WBSCR28 Homo sapiens (Human) membrane [GO:0016020] SSLLGILLQVTRLSVLR 1 28.3 0.82965 -0.024259 0 0 0 0 0 0 0 0 0 5.15097 0 0 Q6ULP2 AFTIN_HUMAN Aftiphilin AFTPH AFTH Homo sapiens (Human) intracellular transport [GO:0046907]; protein transport [GO:0015031] AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276] KPKREEHLSEEAIK;VTDAFARLMSTVEK 2 3 0.9804 -1.6496 0 0 0 0 0 0 0 11.6155 11.7009 0 0 0 Q6UN15 FIP1_HUMAN Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) FIP1L1 FIP1 RHE Homo sapiens (Human) mRNA processing [GO:0006397] cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] RHESEEGDSHR;YRYREYAER 2 3.4 0.96545 -1.1482 0 0 0 0 0 0 0 0 0 0 9.18765 0 Q6UUV7 CRTC3_HUMAN CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) CRTC3 TORC3 Homo sapiens (Human) cellular response to cAMP [GO:0071320]; energy homeostasis [GO:0097009]; lipid catabolic process [GO:0016042]; macrophage activation [GO:0042116]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cAMP response element binding protein binding [GO:0008140]; transcription coactivator activity [GO:0003713] FHPLHRRSGDKPGR;HHGLVERPSR;QLSSTSPLAPYPTSQMVSSDR 3 7.3 0.97788 -2.1606 0 0 0 0 0 0 0 0 12.6058 4.50449 0 0 Q6UVJ0 SAS6_HUMAN Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) SASS6 SAS6 Homo sapiens (Human) centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; procentriole replication complex [GO:0120099] DLEILHQQNIHQLQNR;FLAGCLKCSKEEK;LITWLNKELNENQLVRK;LSGVEEELQR;SLSAELLK 5 9.7 0.95206 -0.75528 10.5612 0 0 0 9.2317 0 0 0 6.80581 0 0 10.4196 Q6UVK1 CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) CSPG4 MCSP Homo sapiens (Human) angiogenesis [GO:0001525]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; tissue remodeling [GO:0048771] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lamellipodium membrane [GO:0031258]; lysosomal lumen [GO:0043202]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901] GLWVPEGQR;SLNSASYLYEVMERPR 2 1.1 0.92816 -0.47285 0 0 9.42082 0 0 0 0 0 0 0 0 0 Q6UVM3 KCNT2_HUMAN Potassium channel subfamily T member 2 (KNa1.2) (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Slo2.1 Homo sapiens (Human) potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805] plasma membrane [GO:0005886] chloride-activated potassium channel activity [GO:0070089]; intracellular sodium-activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271] AKMDDAEACFILSSRCEVDR;AWAVKDFAPNCPLYVQILKPENKFHIK;LTTSESR;NLFVPVFLNCWLAK 4 6.5 0.96217 -1.0788 9.63019 0 0 0 0 0 0 0 5.71737 8.21485 0 0 Q6UVY6 MOXD1_HUMAN DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X) MOXD1 MOX UNQ2493/PRO5780 Homo sapiens (Human) dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589] endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667] copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] DAQQDYHLEYAMENSTHTIIEFTR;SLRLLNPEK 2 5.4 0.93668 -0.54392 8.14165 0 0 0 0 0 7.50668 0 0 9.80237 0 0 Q6UW02 CP20A_HUMAN Cytochrome P450 20A1 (EC 1.14.-.-) CYP20A1 UNQ667/PRO1301 Homo sapiens (Human) membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LYENGVTDSLK;NHGTVWSEIGK;QYEDALMQLESVLRNIIK 3 8.7 0.95374 -0.78024 0 0 11.8555 0 0 0 0 0 0 0 6.30415 11.0795 Q6UW60 PCSK4_HUMAN Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 Homo sapiens (Human) acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] serine-type endopeptidase activity [GO:0004252] ASKPAHLQAEDWR;LVLALALVRPR;SVVVPTDPWFSK;VCSSCHASCYTCR;VQSRPTPILPLIYIR 5 8.5 0.93162 -0.49014 0 0 0 0 3.74578 7.02203 7.77459 5.9503 0 0 0 0 Q6UWB4 PRS55_HUMAN Serine protease 55 (EC 3.4.21.-) (Testis serine protease 1) (T-SP1) PRSS55 TSP1 UNQ9391/PRO34284 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; flagellated sperm motility [GO:0030317]; proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] serine-type endopeptidase activity [GO:0004252] NTPGIYTSLVNYNLWIEK 1 5.1 0.90299 -0.26693 0 0 0 9.98299 0 0 0 0 0 0 0 0 Q6UWD8 CP054_HUMAN Transmembrane protein C16orf54 C16orf54 UNQ9389/PRO34280 Homo sapiens (Human) membrane [GO:0016020] VTLEQISAFWKREGR 1 6.7 0.50296 0.18871 0 0 0 0 0 0 0 0 0 9.69133 0 0 Q6UWE0 LRSM1_HUMAN E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) LRSAM1 TAL UNQ6496/PRO21356 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IRMEQLMSITQEETESLR;TLNISGNEIQR 2 4 0.94289 -0.62233 0 0 0 0 9.40795 0 0 0 0 0 0 0 Q6UWE3 COLL2_HUMAN Colipase-like protein 2 CLPSL2 C6orf126 UNQ3045/PRO9861 Homo sapiens (Human) digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094] extracellular region [GO:0005576] enzyme activator activity [GO:0008047] CFHHSECYSGCCLMDLDSGGAFCAPR;DLMCSRRCHMI 2 37 0.9801 -1.8193 0 0 0 0 0 9.81722 4.97797 0 0 0 0 0 Q6UWH4 GAK1B_HUMAN Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B) GASK1B C4orf18 ENED FAM198B AD021 UNQ2512/PRO6001 Homo sapiens (Human) Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] ILGLNRTLPSVSRK;LIDVIEHRAK;LVRGPGVR 3 6.2 0.96744 -1.2979 0 0 0 0 0 8.2094 0 0 9.31639 0 0 9.69387 Q6UWJ1 TMCO3_HUMAN Transmembrane and coiled-coil domain-containing protein 3 (Putative LAG1-interacting protein) TMCO3 C13orf11 UNQ2419/PRO4976 Homo sapiens (Human) membrane [GO:0016020] potassium:proton antiporter activity [GO:0015386] FLLAALVLSLILPR;GVNFEAVLRVEEEEANSK;ILVLIGQILFSLAAVFLLCLVIK;ILVLIGQILFSLAAVFLLCLVIKK;YLIGPYYR 5 9.5 0.96543 -1.243 0 0 0 10.1054 0 7.99774 12.0599 0 6.93239 0 0 0 Q6UWK7 GP15L_HUMAN Protein GPR15LG (Antimicrobial peptide with 57 amino acid residues) (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Protein GPR15 ligand) (Protein GPR15L) (Secreted protein C10orf99) GPR15LG C10orf99 GPR15L UNQ1833/PRO3446 Homo sapiens (Human) defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte chemotaxis [GO:0048247]; mast cell degranulation [GO:0043303]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]; regulation of keratinocyte proliferation [GO:0010837]; regulation of T cell migration [GO:2000404]; T cell homeostasis [GO:0043029] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018] RTRLCCHR 1 9.9 0.97774 -1.5134 0 9.26842 0 0 0 0 0 0 0 0 0 0 Q6UWL2 SUSD1_HUMAN Sushi domain-containing protein 1 SUSD1 UNQ2438/PRO4999 Homo sapiens (Human) membrane [GO:0016020] calcium ion binding [GO:0005509] EIPCNCNFLRLHIHR;ITSVCTEK;LLPLLLLLGLAR;RLLPLLLLLGLAR 4 4.8 0.96238 -1.0797 0 3.99765 3.1547 3.63819 0 8.57716 3.06941 3.58988 4.50252 4.19551 0 0 Q6UWL6 KIRR2_HUMAN Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) KIRREL2 NEPH3 UNQ5827/PRO19646 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057] cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802] GVSPPASPDSR;VIFLCQATAQPPVTGYR;VTSFQWK 3 5.5 0.91436 -0.38041 0 10.0955 3.90833 0 0 0 0 8.42999 0 0 9.75962 0 Q6UWM7 LCTL_HUMAN Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein) LCTL KLPH UNQ3022/PRO9820 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]; visual perception [GO:0007601] brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789] beta-glucosidase activity [GO:0008422] GPSIWDVFTHSGKGK 1 2.6 0.88066 -0.1686 0 0 0 8.54763 0 0 0 0 0 0 0 0 Q6UWM9 UD2A3_HUMAN UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17) UGT2A3 UNQ2559/PRO6239 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210] membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] RSDKSALVFLLLQLFCVGCGFCGK 1 4.6 0.62973 0.1736 0 0 0 0 0 0 7.62469 0 0 0 0 0 Q6UWN0 LYPD4_HUMAN Ly6/PLAUR domain-containing protein 4 LYPD4 UNQ2552/PRO6181 Homo sapiens (Human) extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552] MSCGAGCYK 1 4.3 0.91149 -0.32513 0 0 0 0 0 0 0 5.46441 0 0 0 0 Q6UWP7 LCLT1_HUMAN Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1) LCLAT1 AGPAT8 ALCAT1 LYCAT UNQ1849/PRO3579 Homo sapiens (Human) cardiolipin acyl-chain remodeling [GO:0035965]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; O-acyltransferase activity [GO:0008374] QPHLNSKK;YSYLRLEK 2 3.9 0.96476 -1.2095 0 11.3691 0 0 0 0 0 0 0 0 0 0 Q6UWP8 SBSN_HUMAN Suprabasin SBSN UNQ698/PRO1343 Homo sapiens (Human) extracellular exosome [GO:0070062] LGHGVNNAAGQAGKEADK;VIEGINRGLSNAER 2 13 0.9798 -2.0015 0 0 0 0 9.40423 0 0 8.66288 0 0 0 0 Q6UWQ5 LYZL1_HUMAN Lysozyme-like protein 1 (EC 3.2.1.17) LYZL1 LYC2 UNQ648/PRO1278 Homo sapiens (Human) extracellular region [GO:0005576] lysozyme activity [GO:0003796] DLSEWKK 1 4.7 0.78345 0.030315 0 0 10.5424 0 0 0 0 0 0 0 0 0 Q6UWQ7 IGFL2_HUMAN Insulin growth factor-like family member 2 IGFL2 UNQ645/PRO1275 Homo sapiens (Human) extracellular space [GO:0005615] signaling receptor binding [GO:0005102] FSVSGMRTDYPR 1 9.2 0.92401 -0.4495 0 0 0 5.74698 0 0 0 0 0 0 0 0 Q6UWR7 ENPP6_HUMAN Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6) ENPP6 UNQ1889/PRO4334 Homo sapiens (Human) choline metabolic process [GO:0019695]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] AVKLGTLLLALALGLAQPASAR;AVKLGTLLLALALGLAQPASARR;LGTLLLALALGLAQPASAR;LGTLLLALALGLAQPASARRK;LLVFLLDGFR 5 7.7 0.73536 0.11022 0 5.16157 0 10.7285 0 8.00731 0 0 4.43122 0 8.33401 6.71273 Q6UWU4 CF089_HUMAN Bombesin receptor-activated protein C6orf89 (Amfion) C6orf89 BRAP UNQ177/PRO203 Homo sapiens (Human) chromatin remodeling [GO:0006338]; epithelial cell proliferation [GO:0050673]; positive regulation of cell cycle [GO:0045787]; wound healing [GO:0042060] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] MDLAANEISIYDK 1 3.7 0.93662 -0.55867 0 0 0 0 0 0 0 0 0 8.34145 0 0 Q6UWV2 MPZL3_HUMAN Myelin protein zero-like protein 3 MPZL3 UNQ2966/PRO7425 Homo sapiens (Human) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; hair cycle [GO:0042633] plasma membrane [GO:0005886] CAECLDSDYEETY 1 5.5 0.80853 0.010834 0 0 0 0 5.39019 0 0 0 0 0 0 0 Q6UWX4 HIPL2_HUMAN HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) extracellular region [GO:0005576] NIVLTTPWIGDER;RIPFRPLAKTVLDLLK 2 4 0.40707 0.20621 0 0 0 0 0 0 11.7143 0 0 0 5.0283 0 Q6UWY0 ARSK_HUMAN Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) (Telethon sulfatase) ARSK TSULF UNQ630/PRO1246 Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; glucuronate-2-sulfatase activity [GO:0015024]; metal ion binding [GO:0046872] DVAFLLR;GLDPNYTTWMDVMER 2 4.1 0.92886 -0.48239 0 0 0 0 0 0 0 0 4.80756 0 0 0 Q6UWY5 OLFL1_HUMAN Olfactomedin-like protein 1 OLFML1 UNQ564/PRO1126 Homo sapiens (Human) signal transduction [GO:0007165] extracellular space [GO:0005615] KQILTLSWQGTGQVIYKGFLFFHNQATSNEIIK 1 8.2 0.96348 -1.1099 0 8.14068 0 0 0 0 0 0 0 0 0 0 Q6UX04 CWC27_HUMAN Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) CWC27 SDCCAG10 UNQ438/PRO871 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005] DASMQDSDTFEIYDPR 1 3.4 0.78295 0.022959 0 0 0 0 0 0 0 0 0 0 3.61871 0 Q6UX06 OLFM4_HUMAN Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD) OLFM4 GW112 UNQ362/PRO698 Homo sapiens (Human) cell adhesion [GO:0007155]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] DYSPQHPNK;LDIVMHKMQEK 2 3.9 0.98012 -1.8668 0 0 0 0 0 0 5.49611 0 0 0 10.9136 0 Q6UX07 DHR13_HUMAN Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) (Protein SDR7C5) DHRS13 SDR7C5 UNQ419/PRO853 Homo sapiens (Human) extracellular region [GO:0005576]; membrane [GO:0016020] oxidoreductase activity [GO:0016491] LDRPVVGWR 1 2.4 0.64094 0.17258 0 0 0 9.74116 0 0 0 0 0 11.5158 0 0 Q6UX15 LAYN_HUMAN Layilin LAYN UNQ208/PRO234 Homo sapiens (Human) cell surface [GO:0009986]; focal adhesion [GO:0005925]; membrane [GO:0016020]; ruffle [GO:0001726] carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] ESGWVENEIYGY;RPGTALQAVLLAVLLVGLR 2 8.1 0.78065 0.032941 0 0 0 0 0 0 0 0 0 6.16267 0 0 Q6UX41 BTNL8_HUMAN Butyrophilin-like protein 8 BTNL8 UNQ702/PRO1347 Homo sapiens (Human) adaptive immune response [GO:0002250]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] FISVFPR;HGQAELR 2 2.8 0.96492 -1.1403 0 0 0 0 0 0 0 0 0 10.0523 0 0 Q6UX41 BTNL8_HUMAN Butyrophilin-like protein 8 BTNL8 UNQ702/PRO1347 Homo sapiens (Human) adaptive immune response [GO:0002250]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] GPGPKKENPGGTGLEK 1 4.8 0.8495 -0.070911 0 0 0 0 0 0 0 0 0 5.42824 0 0 Q6UX68 XKR5_HUMAN XK-related protein 5 XKR5 XRG5 UNQ2754/PRO6493 Homo sapiens (Human) apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] ELSHHAAVGVWVSLPQLRTAHEPCLTSTPK 1 4.4 0.87602 -0.12108 0 0 0 0 0 0 0 8.51795 0 0 0 0 Q6UX71 PXDC2_HUMAN Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) PLXDC2 TEM7R UNQ2514/PRO6003 Homo sapiens (Human) membrane [GO:0016020] CGPCVSSQIGFNCSWCSK 1 3.4 0.78456 0.018395 0 0 0 0 0 0 0 5.72421 7.14456 0 0 0 Q6UX72 B3GN9_HUMAN "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (BGnT-9) (Beta-1,3-Gn-T9) (Beta-1,3-N-acetylglucosaminyltransferase 9) (Beta3Gn-T9) (EC 2.4.1.-)" B3GNT9 UNQ1922/PRO4397 Homo sapiens (Human) poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758]; UDP-glycosyltransferase activity [GO:0008194] DQRRFPLLINQPHK 1 3.5 0.97728 -1.4941 0 0 0 0 0 0 0 0 0 8.02708 0 0 Q6UX73 CP089_HUMAN UPF0764 protein C16orf89 C16orf89 UNQ904/PRO1925 Homo sapiens (Human) cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] protein homodimerization activity [GO:0042803] DIFMENIMFCGMGGFSDFYK;VGMLGEK 2 6.7 0.916 -0.3476 8.54701 0 0 8.24165 0 0 0 0 0 0 0 0 Q6UXA7 CF015_HUMAN Uncharacterized protein C6orf15 (Protein STG) C6orf15 STG UNQ1840/PRO3566 Homo sapiens (Human) extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] SIGVVEEK 1 2.5 0.070376 0.42055 0 0 0 0 0 0 0 0 0 12.9265 12.8026 0 Q6UXC1 AEGP_HUMAN Apical endosomal glycoprotein (MAM domain-containing protein 4) MAMDC4 AEGP UNQ3001/PRO9742 Homo sapiens (Human) protein transport [GO:0015031] Golgi apparatus [GO:0005794]; membrane [GO:0016020] DREVSCNFERDTCSWYPGHLSDTHWR;VTFSATR 2 2.7 0.92931 -0.48475 0 0 0 0 0 0 0 0 3.40463 0 0 0 Q6UXD5 SE6L2_HUMAN Seizure 6-like protein 2 SEZ6L2 PSK UNQ1903/PRO4349 Homo sapiens (Human) regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] GPEMGYLPGSDR;SPTNRLLLHFQSPR 2 2.9 0.95225 -0.67287 0 8.32854 0 0 0 0 0 0 8.37369 0 0 0 Q6UXE8 BTNL3_HUMAN Butyrophilin-like protein 3 (Butyrophilin-like receptor) BTNL3 BTNLR COLF4100 UNQ744/PRO1472 Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] FFRNQFHAVVHLYRDGEDWESK;HGQAELR 2 6.7 0.86476 -0.087715 0 0 0 0 0 0 0 0 0 0 0 5.93727 Q6UXF7 CL18B_HUMAN C-type lectin domain family 18 member B (Mannose receptor-like protein 1) CLEC18B MRLP1 UNQ306/PRO347 Homo sapiens (Human) endosome [GO:0005768]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; sarcoplasmic reticulum [GO:0016529] polysaccharide binding [GO:0030247] CSLQCVHGRFREEECSCVCDIGYGGAQCASESCPR 1 12.6 0.84919 -0.070451 0 0 0 0 0 0 0 7.19594 0 0 0 0 Q6UXG2 ELAP1_HUMAN Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) ELAPOR1 EIG121 KIAA1324 UNQ2426/PRO4985 Homo sapiens (Human) autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of vacuole organization [GO:0044090] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] RNA binding [GO:0003723] QGSSFCKLCPANSYSNK;TNNSTCQPCPYGSYSNGSDCTR;WMKTTEK 3 4.5 0.97483 -2.396 0 0 0 0 0 0 0 0 0 0 0 9.90483 Q6UXG3 CLM9_HUMAN CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g) CD300LG CLM9 TREM4 UNQ422/PRO846 Homo sapiens (Human) immune system process [GO:0002376]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886] NEKFCLSR;NEKFCLSRLTAEEK 2 4.2 0.91654 -0.42588 0 0 0 0 0 0 0 0 0 7.2031 8.92359 0 Q6UXG8 BTNL9_HUMAN Butyrophilin-like protein 9 BTNL9 UNQ1900/PRO4346 Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] HYWEVHVGRRSR 1 2.2 0.959 -1.0364 0 0 0 0 0 0 0 0 0 0 0 11.9586 Q6UXH0 ANGL8_HUMAN Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein) ANGPTL8 C19orf80 RIFL UNQ599/PRO1185 Homo sapiens (Human) cell maturation [GO:0048469]; fat cell differentiation [GO:0045444]; lipid metabolic process [GO:0006629]; positive regulation of protein processing [GO:0010954]; regulation of lipid metabolic process [GO:0019216]; regulation of lipoprotein metabolic process [GO:0050746]; triglyceride homeostasis [GO:0070328] extracellular region [GO:0005576] hormone activity [GO:0005179] DSVQRLEVQLRSAWLGPAYR 1 10.1 0.95626 -0.99643 0 0 0 9.42028 0 0 0 0 0 0 0 0 Q6UXH1 CREL2_HUMAN Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) CRELD2 UNQ185/PRO211 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756] NANGSYTCEGGPGGR;RAALGLLPLLLLLPPAPEAAK 2 12.7 0.26768 0.26729 0 0 0 0 0 0 0 0 0 6.56137 0 0 Q6UXH8 CCBE1_HUMAN Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog) CCBE1 KIAA1983 UNQ1921/PRO4395 Homo sapiens (Human) lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell migration [GO:1904977]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of protein processing [GO:0010954]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; venous blood vessel morphogenesis [GO:0048845] collagen trimer [GO:0005581]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; protease binding [GO:0002020] GPVGPPGAPGR;VLCTCYPGYR 2 5.2 0.94183 -0.61618 0 0 0 0 0 0 0 0 0 6.85162 0 0 Q6UXH9 PAMR1_HUMAN Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP FP938 UNQ699/PRO1344 Homo sapiens (Human) extracellular region [GO:0005576] calcium ion binding [GO:0005509] EVVGYTIPCCRNEENECDSCLIHPGCTIFENCKSCR;ISDLVRRR;NEENECDSCLIHPGCTIFENCKSCR 3 6.1 0.88566 -0.19536 10.793 0 0 0 0 7.01725 0 6.40218 0 0 0 0 Q6UXI7 VITRN_HUMAN Vitrin VIT UNQ647/PRO1277 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510] extracellular region [GO:0005576]; interstitial matrix [GO:0005614] glycosaminoglycan binding [GO:0005539] GGLSNVGR;IKRPKFTVPQINCDVK 2 3.5 0.94045 -0.58518 0 8.0086 0 0 0 0 0 0 0 6.42821 0 0 Q6UXI7 VITRN_HUMAN Vitrin VIT UNQ647/PRO1277 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510] extracellular region [GO:0005576]; interstitial matrix [GO:0005614] glycosaminoglycan binding [GO:0005539] IKRPKFTVPQINCDVK;VIESKPSESMNTRR 2 14.8 0.6414 0.17253 0 0 0 0 0 0 0 0 0 0 8.60859 0 Q6UXI9 NPNT_HUMAN Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like) NPNT EGFL6L POEM UNQ295/PRO334 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; pilomotor reflex [GO:0097195]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; smooth muscle contractile fiber [GO:0030485] calcium ion binding [GO:0005509]; integrin binding [GO:0005178] DPAGGQYLTVSAAKAPGGK;YQCHDIDECSLGQYQCSSFAR 2 7.1 0.95523 -0.81819 0 0 0 0 0 0 13.7536 0 14.3041 0 6.86258 0 Q6UXK5 LRRN1_HUMAN Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) LRRN1 KIAA1497 Nbla10449 UNQ693/PRO1338 Homo sapiens (Human) positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] DGSADTKPTQVDTSR;LKELGINNMGELVSVDR 2 4.5 0.87642 -0.13255 0 0 0 0 0 0 0 0 8.9587 0 0 0 Q6UXM1 LRIG3_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) LRIG3 LIG3 UNQ287/PRO326/PRO335 Homo sapiens (Human) otolith morphogenesis [GO:0032474] cytoplasmic vesicle membrane [GO:0030659]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] ECYPCSHPSEESCER 1 1.3 0.65897 0.16906 0 0 0 0 4.7575 0 0 0 0 0 0 0 Q6UXN8 CLC9A_HUMAN C-type lectin domain family 9 member A (CD antigen CD370) CLEC9A UNQ9341/PRO34046 Homo sapiens (Human) positive regulation of cytokine production [GO:0001819]; receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; membrane [GO:0016020] carbohydrate binding [GO:0030246] HEEEIYTSLQWDSPAPDTYQK;LIQQERALLNFTEWK;LLQVSTIAMQQQEK 3 20.7 0.88269 -0.16374 0 0 0 0 9.61941 0 0 0 0 7.99628 6.0781 0 Q6UXN9 WDR82_HUMAN WD repeat-containing protein 82 WDR82 SWD2 TMEM113 WDR82A UNQ9342/PRO34047 Homo sapiens (Human) "DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]" chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PTW/PP1 phosphatase complex [GO:0072357]; Set1C/COMPASS complex [GO:0048188] chromatin binding [GO:0003682] TIRLWDLR 1 2.6 0.94156 -0.60099 0 0 0 0 8.0486 0 0 0 0 0 0 0 Q6UXR4 SPA13_HUMAN Putative serpin A13 SERPINA13P SERPINA13 UNQ6121/PRO20043 Homo sapiens (Human) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] FSGLGAR;GKMRHLEDALLPETLIK;LLLTMDQRR 3 10.7 0.91644 -0.34991 12.603 0 0 0 0 0 9.58541 10.6811 10.9807 11.6617 11.835 0 Q6UXT8 ALKL1_HUMAN ALK and LTK ligand 1 (Augmentor beta) (AUG-beta) ALKAL1 FAM150A UNQ9433/PRO34745 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] DSNLKDKFIK;HFTGPVTFSPECSKHFHR;SAEIFPRDSNLK 3 27.1 0.98076 -1.6311 0 0 0 0 0 6.43283 0 0 0 7.56887 0 0 Q6UXT9 ABH15_HUMAN Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) ABHD15 UNQ6510/PRO21435 Homo sapiens (Human) adipose tissue development [GO:0060612]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576]; membrane [GO:0016020] monoacylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338] GLSRHRASFLGGR 1 2.8 0.97831 -1.5076 0 0 0 0 0 0 0 0 0 0 9.78717 0 Q6UXU6 TMM92_HUMAN Transmembrane protein 92 TMEM92 UNQ5801/PRO19608 Homo sapiens (Human) membrane [GO:0016020]; nucleoplasm [GO:0005654] CCGDSCCQENELFPGPVR;GFKCCGDSCCQENELFPGPVR 2 13.2 0.71524 0.14342 0 0 0 0 0 0 7.91439 0 6.51709 0 7.49506 0 Q6UXV0 GFRAL_HUMAN GDNF family receptor alpha-like GFRAL C6orf144 UNQ9356/PRO34128 Homo sapiens (Human) GDF15-GFRAL signaling pathway [GO:0160144]; negative regulation of appetite [GO:0032099]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; response to metformin [GO:1901558]; stress-activated protein kinase signaling cascade [GO:0031098] actin cytoskeleton [GO:0015629]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167]; hormone activity [GO:0005179]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023] RHYRTFQSK 1 2.3 0.82542 -0.019855 0 0 0 0 0 0 0 11.5557 0 0 0 0 Q6UXV1 IZUM2_HUMAN Izumo sperm-egg fusion protein 2 IZUMO2 C19orf41 SCRL UNQ6978/PRO21961 Homo sapiens (Human) membrane [GO:0016020] FQLEQLQAR 1 4.1 0.79485 0.015567 0 0 0 0 0 0 0 0 0 0 5.82634 11.1536 Q6UXV4 MIC27_HUMAN MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) APOOL CXorf33 FAM121A MIC27 UNQ8193/PRO23204 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] extracellular region [GO:0005576]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]; SAM complex [GO:0001401] GVYVFVK;YVEEQPGHLQMGFASIR 2 9 0.42802 0.19554 0 0 10.9905 0 0 0 0 0 0 0 7.01089 0 Q6UXX5 ITIH6_HUMAN Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein) ITIH6 ITIH5L UNQ6369/PRO21074 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] AYTITISRSSISLRGEGTLR;YPLHTRPRVPAPK 2 2.5 0.93026 -0.47776 0 0 0 10.0385 0 0 0 7.25578 0 0 0 0 Q6UXX9 RSPO2_HUMAN R-spondin-2 (Roof plate-specific spondin-2) (hRspo2) RSPO2 UNQ9384/PRO34209 Homo sapiens (Human) bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; dopaminergic neuron differentiation [GO:0071542]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; limb development [GO:0060173]; lung growth [GO:0060437]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; trachea cartilage morphogenesis [GO:0060535] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102] DTILCPTIAESRR;GCRIENCDSCFSK;GCRIENCDSCFSKDFCTK 3 17.3 0.91125 -0.32426 11.768 0 11.2458 0 0 0 0 0 9.01806 0 0 0 Q6UXY8 TMC5_HUMAN Transmembrane channel-like protein 5 TMC5 UNQ8238/PRO33604 Homo sapiens (Human) extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] FGTSVLSYFNFLR;LVERYEMPR;NLSTEIR;RSVQEGNPR;SKNSLSEILNSISLWQK;TSSIQPSFRHR 6 6.6 0.97514 -4.0496 10.1501 4.94402 0 10.5389 0 10.16 11.6091 0 11.6509 0 0 11.0452 Q6UXZ0 TMIG1_HUMAN Transmembrane and immunoglobulin domain-containing protein 1 TMIGD1 TMIGD UNQ9372/PRO34164 Homo sapiens (Human) brush border assembly [GO:1904970]; cell aggregation [GO:0098743]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to hydroperoxide [GO:0071447]; intestinal epithelial cell maturation [GO:0060574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of membrane permeability [GO:0090559]; response to nutrient [GO:0007584] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803] EEELLWYR;EEGRVDLK;FLLLVILFLPR 3 10.3 0.9539 -0.90592 0 0 0 5.33989 11.3329 0 0 0 0 9.69284 0 0 Q6UXZ3 CLM5_HUMAN CMRF35-like molecule 5 (CLM-5) (CD300 antigen-like family member D) (CMRF35-A4) (CD antigen CD300d) CD300LD CD300D CMRF35A4 UNQ9218/PRO28686 Homo sapiens (Human) immune response-activating signaling pathway [GO:0002757] plasma membrane [GO:0005886] TNGSEQEVKKNR 1 6.2 0.96429 -1.1741 0 0 0 0 0 0 12.0044 11.5061 0 0 0 0 Q6UXZ4 UNC5D_HUMAN Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D) UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692 Homo sapiens (Human) apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; pyramidal neuron differentiation [GO:0021859]; regulation of neuron migration [GO:2001222] cell surface [GO:0009986]; plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] ADHNLIIR;EVFINVTR;IRECTAPPPRNGGK 3 3.1 0.96776 -1.3038 0 0 0 0 9.83086 0 0 0 0 0 0 0 Q6UY01 LRC31_HUMAN Leucine-rich repeat-containing protein 31 LRRC31 UNQ9367/PRO34156 Homo sapiens (Human) ILDAAFRYLGELRK 1 2.5 0.86514 -0.087266 6.33994 0 0 0 0 0 0 0 0 0 0 0 Q6UY14 ATL4_HUMAN ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1) ADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012 Homo sapiens (Human) apoptotic process [GO:0006915]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; pigment cell development [GO:0070285]; positive regulation of apoptotic process [GO:0043065] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] identical protein binding [GO:0042802]; protease binding [GO:0002020] AGGTVFR;SIINGNWAVDPPGSYR 2 2.1 0.91003 -0.28903 0 0 0 0 6.35915 0 0 0 0 0 10.0482 0 Q6UY27 PATE2_HUMAN Prostate and testis expressed protein 2 (PATE-like protein M) (PATE-M) PATE2 C11orf38 UNQ3112/PRO10144 Homo sapiens (Human) extracellular space [GO:0005615] LSCMTSCEDINFLGFTK 1 15 0.78157 0.021412 0 0 0 7.52623 0 0 0 0 0 0 0 0 Q6UYE1 LEU7_HUMAN Leukemia-associated protein 7 (Deleted in lymphocytic leukemia 7) DLEU7 LEU7 Homo sapiens (Human) DLNAAHQCLK;GGGVGTR;RTAARANSPEEEVVR 3 14.5 0.91733 -0.39922 0 10.8138 0 0 0 8.84128 0 0 0 0 9.97284 0 Q6V0I7 FAT4_HUMAN Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurogenesis [GO:0022008] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ANDQAVPIETR;DINDNAPK;EDSSSGR;EEQSFYQLK;ESLMRRR;LSTISSLDR;SKYSLLVR 7 1.2 0.97591 -4.5782 9.71392 0 0 9.61056 0 0 0 0 0 4.794 0 0 Q6V0L0 CP26C_HUMAN Cytochrome P450 26C1 (CYP26C1) (EC 1.14.14.1) CYP26C1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; neural crest cell development [GO:0014032]; organelle fusion [GO:0048284]; retinoic acid catabolic process [GO:0034653]; vitamin metabolic process [GO:0006766] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" SQWPQSAHILLGSHTLLGAVGEPHRR;TILLGEHR 2 6.5 0.93109 -0.48983 0 0 0 0 9.9911 0 0 0 0 0 0 0 Q6V1P9 PCD23_HUMAN Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ) DCHS2 CDH27 CDHJ PCDH23 PCDHJ Homo sapiens (Human) cell-cell adhesion [GO:0098609]; condensed mesenchymal cell proliferation [GO:0072137]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nephron development [GO:0072006] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEAAAHR;ISQTTPPGTALYLAR;QKDTINNYEEK 3 1 0.95213 -0.71246 11.334 0 7.96936 5.66352 0 6.21669 5.18365 0 0 0 0 0 Q6V1X1 DPP8_HUMAN Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) DPP8 DPRP1 MSTP097 MSTP135 MSTP141 Homo sapiens (Human) apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236] LNTLASLGYVVVVIDNR;TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLR;YSWSQLK 3 6.7 0.95213 -0.71718 8.34029 0 0 0 0 0 0 0 0 0 0 11.1098 Q6V702 CF299_HUMAN Cilia- and flagella-associated protein 299 CFAP299 C4orf22 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] AAIEIAR;LKTEDFEVYFTGK 2 8.6 0.9649 -1.2346 0 0 12.1444 10.2337 10.1054 0 0 0 0 0 0 0 Q6V9R5 ZN562_HUMAN Zinc finger protein 562 ZNF562 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QCVAVHTGKKSEK;SFECKECGRSFR 2 5.9 0.97627 -1.4684 0 0 0 0 0 0 0 6.60848 0 0 0 0 Q6VAB6 KSR2_HUMAN Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1) KSR2 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GMLFGLK;LSHPGHFWK;TLYSVVR;TLYSVVRDAKIVLDVNK 4 3.5 0.95713 -0.99812 0 0 0 0 0 0 0 0 0 0 11.1478 11.7604 Q6VMQ6 MCAF1_HUMAN Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) ATF7IP MCAF MCAF1 Homo sapiens (Human) DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] ATP hydrolysis activity [GO:0016887]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] RYMEEEYEAEFQVK;TLAELKTR;VEKIECNK;VIQWLLEEKLCALQCAVFDK 4 3.9 0.97994 -1.8333 0 0 8.26875 0 7.71918 0 11.3189 0 14.3335 0 0 0 Q6VVB1 NHLC1_HUMAN E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1) NHLRC1 EPM2B Homo sapiens (Human) autophagy [GO:0006914]; glycogen biosynthetic process [GO:0005978]; negative regulation of translation [GO:0017148]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of protein localization to plasma membrane [GO:1903076]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LQAHLCNPRGVAVSWLTGAIAVLEHPLALGTGVCSTR 1 9.4 0.88654 -0.1919 0 10.8639 0 0 0 0 0 0 0 0 0 0 Q6VVX0 CP2R1_HUMAN Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1) CYP2R1 Homo sapiens (Human) calcitriol biosynthetic process from calciol [GO:0036378]; organic acid metabolic process [GO:0006082]; response to cesium ion [GO:0010164]; response to ionizing radiation [GO:0010212]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "D3 vitamins binding [GO:1902271]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; protein homodimerization activity [GO:0042803]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]" FLDSSGYFAK;GWVDHRRLAVNSFR 2 4.8 0.072347 0.41207 0 0 12.0691 8.808 0 0 12.6159 12.7247 12.7353 0 0 0 Q6W2J9 BCOR_HUMAN BCL-6 corepressor (BCoR) BCOR KIAA1575 Homo sapiens (Human) blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of bone mineralization [GO:0030502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; roof of mouth development [GO:0060021]; specification of axis polarity [GO:0065001] BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] LVYVDLLREEPDAK;VLKPKPSKLAKR 2 1.5 0.93612 -0.53355 0 4.44897 0 0 0 0 0 0 11.9946 0 0 0 Q6W3E5 GDPD4_HUMAN Glycerophosphodiester phosphodiesterase domain-containing protein 4 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 6) (UgpQ) GDPD4 GDE6 UGPQ Homo sapiens (Human) lipid metabolic process [GO:0006629] membrane [GO:0016020] glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872] FVIFDLHRPPPKHPLR 1 2.6 0.81413 -0.016465 0 0 0 9.91037 0 0 0 0 0 0 0 0 Q6W4X9 MUC6_HUMAN Mucin-6 (MUC-6) (Gastric mucin-6) MUC6 Homo sapiens (Human) maintenance of gastrointestinal epithelium [GO:0030277] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201] DACGCDSGGDCECLCDAVAAYAQACLDK;IFLGGLSVVLADR;KAQCPCILEGYK 3 2.2 0.88669 -0.19165 5.16003 0 8.14185 0 0 0 0 0 9.29898 0 0 0 Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000] FTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDR 1 10 0.3796 0.2189 0 10.1876 0 0 0 2.69877 4.53953 0 0 0 0 0 Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000] SRMTFFVTQLAITEK 1 4.9 0.91591 -0.43354 0 0 0 0 0 0 0 9.90091 0 0 0 0 Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000] MTFFVTQLAITGCAALRLYLRPGVPQHRQIPCHR 1 21.5 0.85263 -0.08002 0 0 0 0 0 0 0 0 0 0 0 10.8277 Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000] YLQVMVMK 1 5.6 0.93334 -0.50631 0 0 0 0 0 0 0 0 10.3946 0 0 0 Q6WBX8 RAD9B_HUMAN Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B) RAD9B Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573] checkpoint clamp complex [GO:0030896]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GLALRCVNSSR;ISDEFWLDPSK 2 5.2 0.96566 -1.1448 0 0 10.4756 0 0 0 0 0 0 0 0 0 Q6WCQ1 MPRIP_HUMAN Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) MPRIP KIAA0864 MRIP RHOIP3 Homo sapiens (Human) actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] QLRNIRSK;VALGREQSAREGYVLQATCER 2 2.8 0.97353 -2.4747 0 0 0 0 0 0 0 0 0 10.2148 0 8.82531 Q6WKZ4 RFIP1_HUMAN Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) RAB11FIP1 RCP Homo sapiens (Human) negative regulation of adiponectin secretion [GO:0070164]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037] small GTPase binding [GO:0031267] DVAKGSEGENPLTVPGREK;KEGLSFLGGLRSK;QEEELPRFPCK;TASTDLKQLNQVNFTLPKK 4 4.8 0.97293 -2.5926 0 0 0 11.0127 10.8701 10.3537 0 0 0 0 0 0 Q6WN34 CRDL2_HUMAN Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) CHRDL2 BNF1 CHL2 UNQ765/PRO1557 Homo sapiens (Human) cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of BMP signaling pathway [GO:0030514]; ossification [GO:0001503] cytoplasm [GO:0005737]; extracellular space [GO:0005615] BMP binding [GO:0036122] STAASQPAPNQAAQHPSR 1 12.7 0.61827 0.17379 0 5.76734 0 0 0 0 0 0 0 0 0 0 Q6WRI0 IGS10_HUMAN Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of neuron migration [GO:2001222] extracellular region [GO:0005576] CACYMPTEVHCTFR;EQEPQKKNR;HFPPSARR;IDPQHWAALLEK;RTEVNFGDK;TTREDAGK;VHLTVITAAPRIRQSNK;VSSTNEAK 8 3.2 0.97399 -3.0414 0 0 0 8.85944 8.25791 9.7873 7.78143 0 0 0 3.99783 0 Q6WRX3 ZY11A_HUMAN Protein zyg-11 homolog A ZYG11A ZYG11 Homo sapiens (Human) Cul2-RING ubiquitin ligase complex [GO:0031462] ELLAIVK;ELSSKLVTEDVLK;ILVDVPFDR;LESLDISNTLVTDISALLTCKDR;LVNIQKAK;VMTWQGK 6 8.8 0.97442 -2.4439 9.9383 0 0 0 7.86672 0 0 8.93148 0 6.9148 0 12.6854 Q6X4T0 CL054_HUMAN Uncharacterized protein C12orf54 C12orf54 HSD-29 HSD-30 HSD29 HSD30 Homo sapiens (Human) GMSNCSMTPMTSAPR 1 11.8 0.78302 0.022711 0 0 0 0 0 0 0 0 0 0 0 6.50895 Q6X4U4 SOSD1_HUMAN Sclerostin domain-containing protein 1 (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) SOSTDC1 USAG1 CDA019 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; epithelial cell fate commitment [GO:0072148]; hair follicle morphogenesis [GO:0031069]; mammary gland bud morphogenesis [GO:0060648]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389] extracellular space [GO:0005615] BMP binding [GO:0036122]; BMP receptor activity [GO:0098821] IQLQCQDGSTR 1 5.3 0.79499 0.015645 0 0 0 0 0 0 0 0 0 0 9.95709 0 Q6X4W1 NSMF_HUMAN NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) NSMF NELF Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to electrical stimulus [GO:0071257]; cellular response to gonadotropin stimulus [GO:0071371]; positive regulation of neuron migration [GO:2001224]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuronal synaptic plasticity [GO:0048168] apical dendrite [GO:0097440]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; euchromatin [GO:0000791]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] calcium-dependent protein binding [GO:0048306] AQSSDLQSSHCTLDEAFEDLDWDTEK;VTFESPLELSAQGK 2 8 0.90161 -0.2625 11.9177 10.2505 11.793 8.4258 8.35337 8.32436 0 0 0 9.70527 0 0 Q6X784 ZPBP2_HUMAN Zona pellucida-binding protein 2 (ZPBP-like protein) ZPBP2 ZPBPL Homo sapiens (Human) acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]; circadian regulation of gene expression [GO:0032922]; membrane lipid catabolic process [GO:0046466]; negative regulation of immunoglobulin production [GO:0002638]; sphingolipid metabolic process [GO:0006665] acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199] KGFIYGK;SQAYIFYHNFNK 2 5.6 0.87805 -0.14063 0 0 0 0 0 0 10.2488 10.8438 0 0 0 0 Q6X9E4 FBW12_HUMAN F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35) FBXW12 FBW12 FBXO12 FBXO35 Homo sapiens (Human) protein ubiquitination [GO:0016567] cytosol [GO:0005829] ELRLALAQPHNFIYKVTK 1 3.9 0.54791 0.18357 0 0 0 0 0 0 0 0 0 11.5892 0 0 Q6XE24 RBMS3_HUMAN "RNA-binding motif, single-stranded-interacting protein 3" RBMS3 Homo sapiens (Human) defense response to tumor cell [GO:0002357]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] LDQPQMYPQYTYYYPHYLQTK 1 4.8 0.86958 -0.1014 0 0 0 0 9.86005 9.83395 0 0 0 0 0 0 Q6XPR3 RPTN_HUMAN Repetin RPTN Homo sapiens (Human) cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] AQLLNSILSVIDVFHK;DSHHNQSERQDK;QRHEEERQNSHHSQPER;QSQDSSSGKK;RDRQTHEDK;VSHKSTSGQAK 6 9.6 0.95965 -1.0452 0 0 8.34864 10.1548 10.4754 0 0 10.8164 0 0 9.90497 0 Q6XPS3 TPTE2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "monoatomic ion channel activity [GO:0005216]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]" ILFIKRFIIYSIR;LIILIRIFHLLHQK;LIILIRIFHLLHQKR;LLRLIILIRIFHLLHQK;SISLAIGLFFLMDVLLR;VFVEGWTHLVRLLRLIILIR 6 13.3 0.17762 0.33868 0 0 10.5762 0 5.29208 0 8.65707 6.90749 4.37407 5.13984 6.17678 0 Q6XQN6 PNCB_HUMAN Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) NAPRT FHIP NAPRT1 Homo sapiens (Human) NAD salvage [GO:0034355]; response to oxidative stress [GO:0006979] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; nicotinate phosphoribosyltransferase activity [GO:0004516]; transferase activity [GO:0016740] ALDCSEVTVR;QTLPGSKAAFR 2 3.9 0.97835 -1.9805 0 0 0 0 0 0 0 0 0 0 9.15861 0 Q6XUX3 DUSTY_HUMAN Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P Homo sapiens (Human) cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] ELCRGFGRYR;KYFSFPVFFFKVPK;LGSEIIDSSTR;LQIALDVVEGIR;SICSQFR 5 5.8 0.96175 -1.075 0 0 0 0 0 0 13.6846 7.85568 0 10.4001 8.42438 0 Q6XYB7 LBX2_HUMAN Transcription factor LBX2 (Ladybird homeobox 2) (Ladybird homeobox protein homolog 2) LBX2 LP3727 Homo sapiens (Human) muscle cell differentiation [GO:0042692]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" TASRAENNSQACRPQR 1 8.2 0.91703 -0.42727 0 0 0 0 0 0 0 11.0911 0 0 0 0 Q6XYQ8 SYT10_HUMAN Synaptotagmin-10 (Synaptotagmin X) (SytX) SYT10 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; sensory perception of smell [GO:0007608]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]" DFTGTSDPYVKMYLLPDR;KPITHWHPLLELPGR 2 6.3 0.93744 -0.56698 0 0 0 5.68994 0 0 0 0 4.2025 0 0 9.75519 Q6XZB0 LIPI_HUMAN Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta) LIPI LPDL PRED5 Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; phospholipase activity [GO:0004620] IFHGQLGR;LFKGVLKER;SIFSGIQFIKCNHQR;SLTYPERPPLCR;TSLCVDCDCFKEK 5 12.4 0.97289 -2.6037 0 5.80361 0 0 0 0 0 12.1418 0 0 10.7383 8.19185 Q6XZB0 LIPI_HUMAN Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta) LIPI LPDL PRED5 Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; phospholipase activity [GO:0004620] IFHGQLGR;KCFLIQTHVHQRTHK;LFKGVLKER;SIFSGIQFIKCNHQR;TSLCVDCDCFKEK 5 16 0.96544 -1.1581 0 0 0 0 0 9.07588 0 0 0 0 0 0 Q6XZF7 DNMBP_HUMAN Dynamin-binding protein (Scaffold protein Tuba) DNMBP ARHGEF36 KIAA1010 TUBA Homo sapiens (Human) cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; presynapse [GO:0098793]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085] ILATLEDGWLEGSLK;LITEQELPERR;QPTATPR;SLAGPGTEPDKILR;YPPEKLFQAER 5 3.7 0.97956 -1.8877 0 0 0 0 0 0 0 5.65378 12.0277 0 9.88638 0 Q6Y288 B3GLT_HUMAN "Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta 3-glucosyltransferase) (Beta-3-glycosyltransferase-like)" B3GLCT B3GALTL B3GTL Homo sapiens (Human) brain development [GO:0007420]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cranial skeletal system development [GO:1904888]; fucose metabolic process [GO:0006004]; gene expression [GO:0010467]; limb development [GO:0060173]; protein O-linked fucosylation [GO:0036066]; protein secretion [GO:0009306]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501] endoplasmic reticulum membrane [GO:0005789] acetylglucosaminyltransferase activity [GO:0008375]; glycosyltransferase activity [GO:0016757] DIFVAVKTCKK;KDIFVAVK;QETQKGFREEL;RYDPSKEWFLGK 4 7 0.93744 -0.56813 10.0174 0 0 0 0 0 8.72588 0 11.3948 0 11.0511 0 Q6Y2X3 DJC14_HUMAN DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) DNAJC14 DRIP78 HDJ3 Homo sapiens (Human) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] dopamine receptor binding [GO:0050780] GEAKPKRR;ITYFALMDGKVYDITEWAGCQR 2 4.3 0.93679 -0.53802 0 11.0256 0 0 0 0 0 0 0 0 5.41799 0 Q6Y7W6 GGYF2_HUMAN GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) GIGYF2 KIAA0642 PERQ2 TNRC15 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; feeding behavior [GO:0007631]; homeostasis of number of cells within a tissue [GO:0048873]; insulin-like growth factor receptor signaling pathway [GO:0048009]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA destabilization [GO:0061157]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; neuromuscular process controlling balance [GO:0050885]; post-embryonic development [GO:0009791]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled ribosome [GO:0072344]; spinal cord motor neuron differentiation [GO:0021522] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635]; vesicle [GO:0031982] cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723] ALQQQQQQQQQK;EEQNGEDEDGGWRLAGSR;QQQQEALRR 3 3 0.91554 -0.3397 0 0 0 0 0 0 0 0 6.74147 8.27435 0 8.3175 Q6YFQ2 CX6B2_HUMAN "Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)" COX6B2 Homo sapiens (Human) oxidative phosphorylation [GO:0006119] mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] LDVEAQEPPK;NCYQNFLDYHRCLKTR 2 29.5 0.91637 -0.4145 0 0 11.4436 8.85686 0 0 0 0 11.2727 0 0 0 Q6YHK3 CD109_HUMAN CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) hair follicle development [GO:0001942]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616]; stem cell proliferation [GO:0072089] cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; side of membrane [GO:0098552] serine-type endopeptidase inhibitor activity [GO:0004867] GISDNYTLALITYALSSVGSPKAK;INYTVPQSGTFK;NKIKLYWSK 3 3.1 0.97787 -1.5284 0 11.7134 0 0 0 0 8.70151 0 0 6.94181 0 0 Q6YHU6 THADA_HUMAN tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein) THADA GITA KIAA1767 Homo sapiens (Human) adaptive thermogenesis [GO:1990845]; lipid homeostasis [GO:0055088]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554] enzyme regulator activity [GO:0030234] CSDPSSKLCATRR;DNQPVLESLGFWEEVR;ENHPECFCK;ENHPECFCKILK;EVKTCDVTAQMVLVCCWR;LPEQWLWSVLEEIK;SGWRPPSPEMLCHLQRMVSEQCHLLSQFFR;TLLSTLPSCTDQCFR;TMFHPSEK 9 6.5 0.97418 -1.423 6.89105 9.72852 10.6102 6.13633 0 0 2.61299 8.25819 9.54531 4.09119 0 7.87922 Q6YN16 HSDL2_HUMAN Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1) HSDL2 C9orf99 SDR13C1 Homo sapiens (Human) cholesterol homeostasis [GO:0042632] membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] oxidoreductase activity [GO:0016491] DGANIVIAAK;GTYLASKACIPYLK;IVKDSLSDDVVK 3 8.6 0.022472 0.61001 0 0 0 0 0 10.4024 0 0 0 0 0 0 Q6YP21 KAT3_HUMAN Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) KYAT3 CCBL2 KAT3 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] cysteine-S-conjugate beta-lyase activity [GO:0047804]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723] FVKWMTKHK;IAAIDSLNQYTR;WSSSDWTLDPQELESK 3 8.1 0.93654 -0.54574 0 7.35799 0 0 8.71146 0 0 0 0 0 11.696 0 Q6ZMB0 B3GN6_HUMAN "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6)" B3GNT6 Homo sapiens (Human) core 3 O-glycan biosynthetic process [GO:0016269]; glycoprotein biosynthetic process [GO:0009101]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047224]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; galactosyltransferase activity [GO:0008378]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]" IQDFLRYRHCR 1 2.9 0.97495 -1.4427 0 0 0 0 0 0 0 0 9.01633 0 0 0 Q6ZMB0 B3GN6_HUMAN "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6)" B3GNT6 Homo sapiens (Human) core 3 O-glycan biosynthetic process [GO:0016269]; glycoprotein biosynthetic process [GO:0009101]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047224]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; galactosyltransferase activity [GO:0008378]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]" SLTAKTLACLLVGVSFLVLQRR 1 8.3 0.86455 -0.087715 0 0 0 0 0 0 3.00992 0 0 0 5.30943 0 Q6ZMH5 S39A5_HUMAN Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5) SLC39A5 ZIP5 Homo sapiens (Human) "BMP signaling pathway [GO:0030509]; cellular response to zinc ion starvation [GO:0034224]; eye development [GO:0001654]; G1 to G0 transition involved in cell differentiation [GO:0070315]; intracellular monoatomic cation homeostasis [GO:0030003]; neural precursor cell proliferation [GO:0061351]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]" basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] HRGLRPR;VQGLRLGQHGPLTGR 2 4.1 0.95001 -0.66543 0 0 0 0 0 0 0 0 0 0 0 11.3554 Q6ZMI0 PPR21_HUMAN Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1) PPP1R21 CCDC128 FERRY2 KLRAQ1 Homo sapiens (Human) early endosome [GO:0005769]; membrane [GO:0016020] RNA binding [GO:0003723] DISKHYSQK;ISKLEQEKEHWMLEAQLAK;NLELSQDMK 3 4.7 0.97919 -1.8831 0 0 0 6.96763 0 0 0 0 0 0 0 0 Q6ZMJ2 SCAR5_HUMAN Scavenger receptor class A member 5 (Scavenger receptor hlg) SCARA5 UNQ2938/PRO28700 Homo sapiens (Human) cellular response to heat [GO:0034605]; endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207] cell surface [GO:0009986]; plasma membrane [GO:0005886] ferritin receptor activity [GO:0070287] FGQGTGR;WGTVCDDGWDKK 2 3.8 0.20386 0.33138 0 0 0 0 0 0 0 0 0 9.33637 9.91819 0 Q6ZMN7 PZRN4_HUMAN PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein) PDZRN4 LNX4 SEMCAP3L Homo sapiens (Human) metal ion binding [GO:0046872] CPLQCQPLAPGELYR;EERSGMTTDDDTMSEMKMGR;ILQINGEDVQNREEAVALLSNDECK;KQHLVRAK;NYNTSIDMQR;STMAATQSSSGQSSK;TDDEEDTGIYVSEVDPNSIAAKDGRIR;TEDFEYEEVELCR;VHNAFLSVTTV 9 13.9 0.98093 -1.6915 10.2798 0 7.78895 0 7.88362 8.64512 0 0 8.40259 0 7.27826 10.1288 Q6ZMN8 CCNI2_HUMAN Cyclin-I2 CCNI2 Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] LLCHLQLAQDREAR;LMPGWCAPISDLLK 2 7.6 0.95195 -0.70935 0 0 0 0 0 0 0 8.51068 0 0 0 0 Q6ZMP0 THSD4_HUMAN Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; microfibril assembly [GO:0160054] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527] hydrolase activity [GO:0016787] EVICVRK;YYNCNVVVQARLCVYNYYK 2 2.6 0.95471 -0.82337 6.93546 0 0 0 0 0 0 0 0 0 0 0 Q6ZMP0 THSD4_HUMAN Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; microfibril assembly [GO:0160054] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527] hydrolase activity [GO:0016787] AWCIFIK;LLGTPGR 2 6.4 0.9632 -1.0921 0 0 0 0 0 0 0 0 0 10.4839 0 0 Q6ZMQ8 LMTK1_HUMAN Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) AATK AATYK KIAA0641 LMR1 LMTK1 Homo sapiens (Human) brain development [GO:0007420]; neuron apoptotic process [GO:0051402] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GLNFEYKWEAGR;VAESMAPDPRTLQR 2 1.9 0.92434 -0.44851 0 0 0 0 7.43688 0 0 0 0 0 0 0 Q6ZMQ8 LMTK1_HUMAN Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) AATK AATYK KIAA0641 LMR1 LMTK1 Homo sapiens (Human) brain development [GO:0007420]; neuron apoptotic process [GO:0051402] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] QWPQREESLPRLCLLLRPR;SLQKQWPQR;VAESMAPDPRTLQR 3 4.2 0.97532 -1.441 8.00781 0 0 0 0 0 0 0 0 0 7.95577 10.3387 Q6ZMS4 ZN852_HUMAN Zinc finger protein 852 ZNF852 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNECGRAFCSNR;CNECGRAFCSNRNLIDHQR;SFNQNSYLIIHQR;SMASLGR 4 7.2 0.95137 -0.71523 0 0 0 6.51677 0 0 0 0 8.1104 6.26155 0 0 Q6ZMS7 ZN783_HUMAN Zinc finger protein 783 ZNF783 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ELYKHVMR;HGSLPLPWPSR;LHTGNGQGWPACPYCGKAFR;VPVTFDDVAVYFSELEWGK 4 10.6 0.97232 -2.698 9.39189 0 0 0 0 0 12.4755 11.9369 0 8.02192 0 0 Q6ZMT1 STAC2_HUMAN SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) STAC2 Homo sapiens (Human) positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; sarcolemma [GO:0042383] metal ion binding [GO:0046872] EQGYMSLKENQICVGVGRSK 1 4.9 0.85005 -0.075725 0 0 0 0 0 0 8.14985 0 0 0 0 0 Q6ZMT4 KDM7A_HUMAN Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65) KDM7A JHDM1D KDM7 KIAA1718 Homo sapiens (Human) chromatin remodeling [GO:0006338]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] DNDLRLLLTNGR;EDGFQPQTYLVQGVK;FPFFEAICWFVAKNLLETLK 3 5 0.95491 -0.83325 0 0 0 10.2395 0 9.74064 0 9.26519 0 0 0 0 Q6ZMT9 DTHD1_HUMAN Death domain-containing protein 1 DTHD1 Homo sapiens (Human) signal transduction [GO:0007165] ESFTVTKKGLALK;EVDEFGNYSCPHYKGTIVVYK;GLALKSSMDSR;RASATINRITPSYFNR 4 7.2 0.97837 -1.9235 3.34696 0 0 0 0 0 11.7805 8.9131 8.0864 0 0 0 Q6ZMU1 C3P1_HUMAN Putative protein C3P1 C3P1 Homo sapiens (Human) extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] LPSSVIR 1 1.9 0.90892 -0.31353 0 0 0 0 0 0 0 0 9.53747 0 0 0 Q6ZMU5 TRI72_HUMAN Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) TRIM72 MG53 Homo sapiens (Human) exocytosis [GO:0006887]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of myotube differentiation [GO:0010832]; plasma membrane repair [GO:0001778]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383] identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylserine binding [GO:0001786]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LDIQLPIISDDFKFQVWR 1 3.8 0.82546 -0.020415 0 0 0 0 0 0 0 0 0 0 0 11.1176 Q6ZMV5 P4R3C_HUMAN Protein PPP4R3C (SMEK homolog 3) (Serine/threonine-protein phosphatase 4 regulatory subunit 3C) PPP4R3C PPP4R3CP SMEK3P Homo sapiens (Human) DNA damage response [GO:0006974]; regulation of double-strand break repair [GO:2000779] nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] CELLFFFK;DETTHDDRR;HTHLILCVLRFMRR 3 4.1 0.91668 -0.41637 0 6.72819 0 0 0 0 0 0 0 5.26021 11.0349 0 Q6ZMV8 ZN730_HUMAN Putative zinc finger protein 730 ZNF730 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECGKAFNWFSHFTTHK;IIHSGEK 2 4.6 0.81246 -0.015792 0 8.56735 0 0 0 0 0 0 0 0 0 0 Q6ZMV9 KIF6_HUMAN Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] LHLVDLAGSERVAK 1 1.7 0.92181 -0.44345 0 0 0 0 0 0 0 0 12.3356 0 0 0 Q6ZMW2 ZN782_HUMAN Zinc finger protein 782 ZNF782 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFLEKAALVTSNSTHPKGK;NVCDKWLISIK;SHTGEKPYECPECGK 3 6.4 0.97485 -3.0697 0 0 0 0 0 0 0 9.22417 10.5217 0 0 0 Q6ZMW3 EMAL6_HUMAN Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) EML6 EML5L Homo sapiens (Human) cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] DYVATGQVGR;EPYICIWDSYNVQTVSLLK;LWDTDFKPITK;SALSTSSK 4 2.5 0.94188 -0.61504 0 0 0 0 7.14466 0 0 0 0 10.9687 0 0 Q6ZMY3 SPOC1_HUMAN SPOC domain-containing protein 1 SPOCD1 Homo sapiens (Human) cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromosome [GO:0005694]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674] NLKKGPVPCAQDR;SMQEVLWTR;VEKRYYQPDDR 3 2.7 0.97824 -1.527 0 0 0 0 0 0 0 0 10.9226 0 0 5.38052 Q6ZMZ0 RN19B_HUMAN E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B) RNF19B IBRDC3 NKLAM Homo sapiens (Human) adaptive immune response [GO:0002250]; natural killer cell mediated cytotoxicity [GO:0042267]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511] cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ubiquitin ligase complex [GO:0000151] ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LNPHDIRLLLADPPLMHKYEEFMLR;LTCEREGCQTEFCYHCK;MNDGSCNHMTCAVCGCEFCWLCMK 3 9 0.97376 -1.4026 0 8.14308 0 0 0 7.43212 0 0 0 0 7.99537 0 Q6ZMZ3 SYNE3_HUMAN Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3) SYNE3 C14orf139 C14orf49 LINC00341 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; establishment of protein localization to membrane [GO:0090150]; nuclear migration [GO:0007097]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; rough endoplasmic reticulum [GO:0005791] actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444] DRDLLHNSLLQR;GLQRDLPGK;ITGELEEMRK;LKELLTMLQLKK;SLEDLVDR;SLEDLVDRCR 6 5.4 0.97446 -3.5376 0 0 4.31346 0 0 0 12.208 0 0 2.20617 0 12.6108 Q6ZN01 MASTR_HUMAN MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein) MAMSTR MASTR Homo sapiens (Human) positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] transcription coregulator activity [GO:0003712] ISQRWRESKPR;TLAASSQR 2 4.6 0.97941 -1.8465 0 0 0 0 0 0 0 0 11.1035 0 0 0 Q6ZN03 CU136_HUMAN Putative uncharacterized protein encoded by LINC00322 LINC00322 C21orf136 NCRNA00322 Homo sapiens (Human) NDLESLLSEGR 1 3.6 0.92885 -0.47332 0 0 0 0 0 0 0 0 10.2826 0 0 0 Q6ZN08 ZNF66_HUMAN Putative zinc finger protein 66 (Zinc finger protein 66 pseudogene) ZNF66 ZNF66P Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GCESVDKCK;RYKCEDCGK;SSNLTTHKK;VHKRGYNGLNQCLTTTQSK 4 8 0.95245 -0.7231 11.3205 11.8028 11.2954 10.9943 10.9082 11.5941 9.78238 0 0 15.7222 15.6437 11.7016 Q6ZN11 ZN793_HUMAN Zinc finger protein 793 ZNF793 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKSCEYNK;GCSHCEK;RQDMLLRPGAAISK 3 7.1 0.95518 -0.81569 5.05446 0 0 6.07688 0 0 0 6.36929 5.52876 0 0 0 Q6ZN16 M3K15_HUMAN Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 Homo sapiens (Human) JNK cascade [GO:0007254]; p38MAPK cascade [GO:0038066] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310] AQEASETK;DDTSRDSAIEWYR;VGMFKIHPEIPEALSAEAR;WGPMKEPTIK 4 3.8 0.92373 -0.44894 0 0 0 0 0 5.54677 0 0 0 0 0 0 Q6ZN16 M3K15_HUMAN Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 Homo sapiens (Human) JNK cascade [GO:0007254]; p38MAPK cascade [GO:0038066] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310] AQEASETK;MEFYSLFHK;VGMFKIHPEIPEALSAEAR;WGPMKEPTIK 4 5.8 0.94213 -0.62063 8.65914 0 0 0 0 0 9.57901 0 0 0 0 0 Q6ZN17 LN28B_HUMAN Protein lin-28 homolog B (Lin-28B) LIN28B CSDD2 Homo sapiens (Human) miRNA catabolic process [GO:0010587]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of primary miRNA processing [GO:2000635]; positive regulation of miRNA catabolic process [GO:2000627]; pre-miRNA processing [GO:0031054]; RNA 3'-end processing [GO:0031123]; RNA destabilization [GO:0050779] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] EGSPLDIPVDVFVHQSKLFMEGFRSLK 1 10.8 0.69561 0.16215 0 0 0 0 0 0 0 8.00084 0 0 0 0 Q6ZN19 ZN841_HUMAN Zinc finger protein 841 ZNF841 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKPYQCDVCGRIFR;NLQEVDFQWK;NPNCGECMK 3 3.6 0.94056 -0.58343 0 5.00131 0 0 0 0 8.68124 2.69468 5.93612 0 6.9197 0 Q6ZN28 MACC1_HUMAN Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) MACC1 Homo sapiens (Human) positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] growth factor activity [GO:0008083] EDCHTERNTR;IDYFLEYFK;SAPLSPK;VLSNCYIYK;VSYVIKKLK 5 5.2 0.974 -2.9907 0 0 0 0 0 0 8.90008 5.43853 0 0 0 0 Q6ZN30 BNC2_HUMAN Zinc finger protein basonuclin-2 BNC2 Homo sapiens (Human) endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; rDNA binding [GO:0000182] SFKSSYSVKLHYR 1 1.2 0.86791 -0.091701 0 0 6.18814 0 0 0 0 0 0 0 0 0 Q6ZN44 UNC5A_HUMAN Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) UNC5A KIAA1976 UNC5H1 Homo sapiens (Human) anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; netrin-activated signaling pathway [GO:0038007]; neuron projection development [GO:0031175] membrane raft [GO:0045121]; neuron projection membrane [GO:0032589]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] YHGSGATPPK 1 1.2 0.91692 -0.42664 0 0 0 0 0 0 0 0 0 0 10.8117 0 Q6ZN54 DEFI8_HUMAN Differentially expressed in FDCP 8 homolog (DEF-8) DEF8 Homo sapiens (Human) lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029] metal ion binding [GO:0046872] CARLSLRK 1 1.6 0.73983 0.10264 0 0 0 0 0 0 8.80855 0 0 0 0 0 Q6ZN55 ZN574_HUMAN Zinc finger protein 574 ZNF574 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CQECGVRFHRPYRLLMHR;LVHAQHFPYR;MTEESEETVLYIEHR;RAHTPNPLHSCPCGK;SFSNLWK 5 7.3 0.78322 0.022739 0 4.34986 0 0 0 0 0 0 0 0 0 0 Q6ZN55 ZN574_HUMAN Zinc finger protein 574 ZNF574 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASLGPGR;ATWANSKER;CQECGVRFHRPYRLLMHR;ERSWAESERGPR;LVHAQHFPYR;RAHTPNPLHSCPCGK;SFSNLWK 7 7.7 0.98128 -1.7033 8.96295 0 0 0 0 0 0 0 16.2552 9.24698 10.7279 0 Q6ZN57 ZFP2_HUMAN Zinc finger protein ZFP2 (Zfp-2) (Zinc finger protein 751) ZFP2 ZNF751 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SSLTVHQVIHTGEKPYECNECGK 1 5 0.80348 0.013332 0 0 0 0 8.07916 0 0 0 0 0 0 0 Q6ZN66 GBP6_HUMAN Guanylate-binding protein 6 (EC 3.6.5.-) (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6) GBP6 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; immune response [GO:0006955] cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EHLLREQIMMLEHTQK;KENIAQLKEK;VQTSNFPRECIR 3 6 0.97495 -2.3669 0 5.18436 14.2581 0 3.93885 0 0 0 0 0 0 0 Q6ZN84 CCD81_HUMAN Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815] DLQMLQRTQR;GIGVLMIRDSKVK;LPMETLVEECGENR;QEEYSRSLLKQMDNR;TAELERVNR;TQREHLADRTAELER;VNQCLQEDWER 7 12 0.97484 -3.9064 0 0 9.00518 0 0 0 0 12.5115 10.1544 10.3881 7.01067 0 Q6ZNA1 ZN836_HUMAN Zinc finger protein 836 ZNF836 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFRVRSILVNHQK;QNSNLVNHQR;SIHTGEKPYVCNECGKAFR 3 4.2 0.98017 -1.7166 0 0 11.525 0 5.82932 6.1505 0 0 0 0 9.0705 7.42911 Q6ZNA4 RN111_HUMAN E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) RNF111 Homo sapiens (Human) global genome nucleotide-excision repair [GO:0070911]; pattern specification process [GO:0007389]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630] VTTDWFSQRK 1 1 0.73285 0.11219 0 0 0 0 0 0 0 0 0 0 9.57675 0 Q6ZNB6 NFXL1_HUMAN NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) NFXL1 OZFP Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" CCPGNCPPCDQNCGR;CCPGNCPPCDQNCGRTLGCRNHK;CENPCHAGSCQPCPR;CKEQCSRPPTCHHTSQEKHR;CNCGNTK;GPCETCRQEVEK;HRCHFGSCPPCHQPCQK;KRDEVAVELSLWQK;LLCGQHK;MPCHKPYLCETK;RSETPSRYYCYCGK;TDGCTGK;VTKTDGCTGKNK;VTVPCGRERTTRPPK 14 18.2 0.9747 -3.2 6.53473 7.14262 8.05393 0 10.5327 9.85384 0 9.54595 10.9449 6.06742 9.9095 12.577 Q6ZNB7 ALKMO_HUMAN Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) AGMO TMEM195 Homo sapiens (Human) ether lipid metabolic process [GO:0046485]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] glyceryl-ether monooxygenase activity [GO:0050479]; iron ion binding [GO:0005506] NRYCIDKNYAGVLIIWDK;VCFIILTLTSIGFLLDQRPKAAIMETLRCLMFLMLYR 2 12.4 0.95517 -0.86387 0 0 7.63713 0 0 0 9.9649 0 0 0 0 0 Q6ZNC4 ZN704_HUMAN Zinc finger protein 704 ZNF704 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] ACQRFLD;VGDSDYSDGEEDFYYTEIK 2 6.3 0.96739 -1.3142 0 0 0 0 0 0 2.78075 0 0 0 0 0 Q6ZNC8 MBOA1_HUMAN Lysophospholipid acyltransferase 1 (LPLAT 1) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase MBOAT1) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1) MBOAT1 OACT1 Homo sapiens (Human) lipid modification [GO:0030258]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of neuron projection development [GO:0010975] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746] ITTLAFQVHDGLGRR;LGITLVSLLLFLTLTK 2 6.3 0.5894 0.17853 0 0 0 0 0 0 0 11.0052 0 0 0 0 Q6ZNC8 MBOA1_HUMAN Lysophospholipid acyltransferase 1 (LPLAT 1) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase MBOAT1) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1) MBOAT1 OACT1 Homo sapiens (Human) lipid modification [GO:0030258]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of neuron projection development [GO:0010975] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746] IFLGLGR;LGITLVSLLLFLTLTK 2 6.6 0.9448 -0.64409 0 0 0 0 0 0 4.9835 0 0 0 0 0 Q6ZNE5 BAKOR_HUMAN Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 ATG14L KIAA0831 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of protein phosphorylation [GO:0001934]; post-transcriptional regulation of gene expression [GO:0010608]; protein targeting to lysosome [GO:0006622]; regulation of macroautophagy [GO:0016241]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207]; response to mitochondrial depolarisation [GO:0098780] "autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]" GTPase binding [GO:0051020]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein-membrane adaptor activity [GO:0043495] KTIDLRSHYER;NLMYLVSPSSEHLGRSGPFEVR 2 6.7 0.96435 -1.1723 0 0 0 0 0 0 8.3486 7.73064 0 0 0 0 Q6ZNE9 RUFY4_HUMAN RUN and FYVE domain-containing protein 4 RUFY4 Homo sapiens (Human) autophagosome assembly [GO:0000045]; cellular response to interleukin-4 [GO:0071353]; positive regulation of macroautophagy [GO:0016239] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] AEEQAQRQEQLLREQEGELQALR;KAEEQAQR 2 4.2 0.878 -0.13591 0 0 0 0 0 0 0 9.34167 0 0 10.0382 0 Q6ZNF0 ACP7_HUMAN Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) ACP7 PAPL PAPL1 Homo sapiens (Human) extracellular region [GO:0005576] acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872] HLVQRQFRWLESDLQK 1 3.7 0.44872 0.19164 0 0 0 0 0 0 0 0 0 10.026 0 0 Q6ZNG0 ZN620_HUMAN Zinc finger protein 620 ZNF620 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FHTGEKLYECNECWK 1 3.6 0.91961 -0.43769 0 0 0 0 0 0 0 0 0 0 5.66218 0 Q6ZNG1 ZN600_HUMAN Zinc finger protein 600 ZNF600 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;CETCDKVFSR;CNECDKAFNQQSNLARHR;CTVCDKAFVRNSYLAR;VFSCGSTLETHK 5 9.1 0.9803 -1.6015 7.7862 7.52348 0 0 0 0 0 0 9.59124 0 11.6636 0 Q6ZNG2 DBX2_HUMAN Homeobox protein DBX2 (Developing brain homeobox protein 2) DBX2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AVFSEDQRK;GVLTGAV 2 4.7 0.33031 0.24337 0 0 0 0 0 7.7301 8.07382 0 0 0 9.88105 0 Q6ZNG9 KRBA2_HUMAN KRAB-A domain-containing protein 2 KRBA2 Homo sapiens (Human) DNA integration [GO:0015074]; regulation of DNA-templated transcription [GO:0006355] nucleic acid binding [GO:0003676] EVIVLYLTLCKQCHQK;GLAPKPMTFK 2 5.3 0.94796 -0.66382 0 0 0 0 0 0 0 0 11.2491 9.46389 0 0 Q6ZNH5 ZN497_HUMAN Zinc finger protein 497 ZNF497 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ELGPADGGRDGAGPR;GSSGLAHHR;RVHTGARPHACR 3 7.2 0.95349 -0.78224 0 0 0 0 9.20124 6.64162 0 0 10.4074 0 0 0 Q6ZNI0 GCNT7_HUMAN "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (EC 2.4.1.-)" GCNT7 C20orf105 Homo sapiens (Human) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] acetylglucosaminyltransferase activity [GO:0008375] KFVEFILTDIHAKDMLQWSK 1 4.7 0.96155 -1.0735 0 0 0 0 0 9.38377 0 0 0 0 0 0 Q6ZNJ1 NBEL2_HUMAN Neurobeachin-like protein 2 NBEAL2 KIAA0540 UNQ253/PRO290 Homo sapiens (Human) platelet formation [GO:0030220]; protein localization [GO:0008104] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] protein kinase binding [GO:0019901] LEAALGR;LLLHYSPQACK;LYELWLLYYAQK;QVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQR;SHVLVGLEDGKLIVVVAGQPSEVR 5 3.3 0.95131 -0.70517 0 11.8315 0 0 0 9.32699 0 0 0 0 6.79025 0 Q6ZNK6 TIFAB_HUMAN TRAF-interacting protein with FHA domain-containing protein B (TIFA-like protein) TIFAB Homo sapiens (Human) auditory behavior [GO:0031223]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mastication [GO:0071626]; myeloid cell differentiation [GO:0030099]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of gene expression [GO:0010468]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; toll-like receptor signaling pathway [GO:0002224]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650] deubiquitinase activator activity [GO:0035800] RHLSLEPYLEK 1 6.8 0.87845 -0.13752 0 0 0 8.45984 0 0 0 0 0 0 0 0 Q6ZNL6 FGD5_HUMAN "FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)" FGD5 ZFYVE23 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] EGTLMKVTGK;GLDEGPR;GVPFSRTVSRVESFEDR;IVCRNCSRNK;MAKVCDGCFGELKK;TLFYSFK;VEGQSRALVIAQELLSSEK 7 5.7 0.97654 -2.183 0 10.1678 7.90244 7.28707 9.46838 6.94498 0 0 0 0 11.7217 0 Q6ZNQ3 LRC69_HUMAN Leucine-rich repeat-containing protein 69 LRRC69 Homo sapiens (Human) intracellular signal transduction [GO:0035556] FVPPPKDWK;MPSALGK;NNIGVLPEELCDLK 3 8.6 0.96034 -1.0545 0 12.2523 0 9.46616 0 0 12.1106 0 0 0 0 0 Q6ZNR0 TMM91_HUMAN Transmembrane protein 91 (Dispanin subfamily C member 3) (DSPC3) TMEM91 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] LPLQPSL 1 5.5 0.70921 0.15935 0 0 8.59141 0 0 12.211 0 0 8.07895 0 0 0 Q6ZNX1 SHLD3_HUMAN Shieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3) SHLD3 FLJ26957 RINN1 Homo sapiens (Human) DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] ALNLHSLYRAR 1 4.4 0.92105 -0.44439 0 0 0 3.40054 0 0 0 0 0 0 0 0 Q6ZP65 BICL1_HUMAN BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A) BICDL1 BICDR1 CCDC64 Homo sapiens (Human) Golgi to secretory granule transport [GO:0055107]; neuron projection development [GO:0031175]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cytoplasm [GO:0005737] dynactin binding [GO:0034452]; small GTPase binding [GO:0031267] DLVLAARLGKALLER;EKSRAVQELSEQNQR;QLQVKVEELTEER 3 7.5 0.981 -1.748 0 0 0 10.2863 0 0 0 0 1.90254 4.14877 8.04472 0 Q6ZP68 ATPUN_HUMAN Putative protein ATP11AUN (Putative ATP11A upstream neighbor protein) ATP11AUN C13orf35 Homo sapiens (Human) AWASSLKMDPAGLEGGPR;GRRSASGTQK 2 23.1 0.9153 -0.37842 0 0 0 9.06614 0 9.09402 0 0 0 8.17976 0 0 Q6ZP82 CC141_HUMAN Coiled-coil domain-containing protein 141 (Coiled-coil protein associated with myosin II and DISC1) CCDC141 CAMDI Homo sapiens (Human) centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799] centrosome [GO:0005813]; cytoplasm [GO:0005737] DSFKDIK;FNYTKKNEK;GYQRQMVPREEIK;IQDYEDILYK;ISAEHPESMMSEVHER;NEVYLMKNTMENQK;RVDHLTEQCSAHK;TIRNLQEQSLGSSLSDNEDR;VGKYSTECK;WLAEELNLFGQSIDYR 10 8.3 0.97822 -6.9862 8.38832 0 0 9.39812 9.74567 10.8531 9.46222 10.8833 8.80142 11.2554 0 0 Q6ZQN7 SO4C1_HUMAN Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) SLCO4C1 OATP4C1 OATPX SLC21A20 Homo sapiens (Human) cell differentiation [GO:0030154]; monoatomic ion transport [GO:0006811]; sodium-independent organic anion transport [GO:0043252]; spermatogenesis [GO:0007283] azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] AGKCETHCAK;HLPGTAEIQAGK 2 3 0.95216 -0.68345 6.33133 0 0 0 0 0 0 0 0 8.59906 0 0 Q6ZQQ2 S31D1_HUMAN Spermatogenesis-associated protein 31D1 (Protein FAM75D1) SPATA31D1 FAM75D1 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] EEEEERKLLSLLK;KGGTFKGFPDWK;RGDFLMWK;SLAQPQSPFR 4 2.7 0.97332 -2.909 0 0 0 0 9.55949 0 0 0 0 11.0386 0 11.6962 Q6ZQQ6 WDR87_HUMAN WD repeat-containing protein 87 (Testis development protein NYD-SP11) WDR87 Homo sapiens (Human) EEDEHFLEMRLSK;EMTKEERDMSEEVEEMATLEEK;ILAMEESEIAK;LAQEERQLAQEERK;LELGEELYR;LKWEEWKQVWENMLSSK;LLQEEEK;LSEEETK;LSPEEEMLQEDKK;LVQVEDSLAK;NWHLLGEPYRSER;REMTKEER;SWKAWKEEWEK;VLSQHSCAR;WLRGLKK 15 5.7 0.97827 -6.8602 6.73457 8.32737 11.5507 10.9606 0 7.28854 0 7.67313 9.49337 9.28297 11.2619 0 Q6ZQX7 LIAT1_HUMAN Protein LIAT1 (Ligand of ATE1 protein) LIAT1 C17orf97 Homo sapiens (Human) non-membrane-bounded organelle assembly [GO:0140694]; protein arginylation [GO:0016598] cytoplasm [GO:0005737]; nucleolus [GO:0005730] molecular condensate scaffold activity [GO:0140693] HLPSDSSTVSLPDFAEIENLANR;INESLRWDGILADPEAEKER;VGLQPSGRLDR 3 11.9 0.9807 -1.6208 0 0 0 0 0 0 10.408 0 0 8.48547 10.2963 10.2428 Q6ZQY2 LR74B_HUMAN Leucine-rich repeat-containing protein 74B LRRC74B Homo sapiens (Human) QGSAQELNLRHR 1 7.5 0.98069 -1.6196 0 0 0 0 0 0 0 0 0 9.10198 0 0 Q6ZQY3 GADL1_HUMAN Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1) GADL1 Homo sapiens (Human) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737]; cytosol [GO:0005829] aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782] DVIHYSVKTNHPR;GSLMLGYQPHR;KCYSAKASYLFQQDK;LIMEEVVLKATDVNEK;LLHGIHR;YKYCPDIK 6 13.4 0.97409 -2.4114 0 0 9.32172 11.4901 0 11.5822 0 9.2132 9.41513 10.4153 0 12.6606 Q6ZR08 DYH12_HUMAN Dynein axonemal heavy chain 12 (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein axonemal heavy chain 7-like) (Dynein heavy chain domain-containing protein 2) DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 Homo sapiens (Human) microtubule-based movement [GO:0007018] axonemal dynein complex [GO:0005858]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVKAVLVAAGNLK;CIIFIDDMNMPALEKYGAQPPIELLR;DVVMDMIK;ILKILITFRISNYFK;IMNTWYPK;ITPAITNYVTDKLGKK;LATSMAK;LAYPESAR;REKLILEIEK;YLNDHFTYNLYCNICR 10 4.1 0.97451 -3.527 0 0 7.32517 0 8.68731 0 12.2802 12.7753 0 0 11.9726 0 Q6ZR37 PKHG7_HUMAN Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 C12orf74 Homo sapiens (Human) Rho protein signal transduction [GO:0007266] guanyl-nucleotide exchange factor activity [GO:0005085] VEKSIRDLEGK;YPLLLKNIWKR 2 3.2 0.26566 0.26466 0 0 0 0 6.4978 0 0 0 12.5727 0 0 0 Q6ZR52 ZN493_HUMAN Zinc finger protein 493 ZNF493 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHIRENSYRCEECGK;IIHNGEKPYK;VILREYVKCGHK 3 4.8 0.93325 -0.51325 0 0 0 0 0 0 6.82972 0 0 0 8.48269 8.70667 Q6ZR85 CQ107_HUMAN Uncharacterized protein C17orf107 C17orf107 Homo sapiens (Human) LLVQGAWLCLCGR 1 6.8 0.86973 -0.098883 0 11.8304 0 0 0 0 0 0 0 0 0 0 Q6ZRC1 CD050_HUMAN Uncharacterized protein C4orf50 C4orf50 Homo sapiens (Human) GNLGQLQKATSESVRK;LHGDQERFHER;LQEELQAKLEELQK;SEREREEAAR;SQDWRNSLR;YVTSESGLRSR 6 4.7 0.97654 -5.5141 13.2195 0 13.2599 9.28889 10.2833 0 0 11.7372 11.4804 9.5371 0 0 Q6ZRF7 ZN818_HUMAN Putative zinc finger protein 818 ZNF818P ZNF818 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] MLERNLTSMMSVEEPLPRPLTSLYIRLSILER;SYRCHECGKAFTQGSR 2 35.3 0.88263 -0.17515 0 0 0 0 0 0 11.4672 0 4.69421 0 0 0 Q6ZRF8 RN207_HUMAN RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; positive regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905033]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270] CTLHAEPYLLFSTDKKLLLCIR;RVAAAASGANTLAGGLGPK 2 6.5 0.96703 -1.2919 11.096 0 0 0 0 0 0 0 0 0 0 11.3679 Q6ZRF8 RN207_HUMAN RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; positive regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905033]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270] CANCDLECSEQAGAAGR;GLEPVSR 2 9.8 0.90941 -0.29598 0 7.38137 8.44584 0 0 0 0 0 0 0 4.39273 0 Q6ZRH7 CTSRG_HUMAN Cation channel sperm-associated auxiliary subunit gamma CATSPERG C19orf15 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] EPCMAEEVCSMSWYTPMPIKK;VRVVQVLWALLAVLLASWR 2 3.5 0.87632 -0.1262 0 0 0 3.5894 9.43993 0 11.5314 9.39006 3.83228 10.7643 10.4544 0 Q6ZRI0 OTOG_HUMAN Otogelin OTOG OTGN Homo sapiens (Human) L-arabinose metabolic process [GO:0046373] apical plasma membrane [GO:0016324]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] alpha-L-arabinofuranosidase activity [GO:0046556] EDCNTCTCTSGK;NTTELCCPLYQCVCENFR;VTIRMTIRK 3 1.3 0.97788 -1.5123 0 0 4.5485 0 0 0 7.97396 0 0 0 0 0 Q6ZRI6 CO039_HUMAN Uncharacterized protein C15orf39 C15orf39 FP6578 Homo sapiens (Human) cytosol [GO:0005829] LLSQLQRFDRTHR 1 1.2 0.8682 -0.091498 0 0 11.0405 0 0 0 0 0 0 0 0 0 Q6ZRI8 RHG36_HUMAN Rho GTPase-activating protein 36 ARHGAP36 Homo sapiens (Human) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] QVAKRVWK;QVEEATGQAAGRR 2 5.1 0.89834 -0.25697 16.7482 9.55361 0 15.1028 0 0 0 0 0 10.388 0 0 Q6ZRK6 CCD73_HUMAN Coiled-coil domain-containing protein 73 (Sarcoma antigen NY-SAR-79) CCDC73 Homo sapiens (Human) EAIQSNKR;ETLAEQHK;FQELQERLNMELELNEK;IIVETQELK;LNMELELNEK;RHAEELNGEINK 6 5 0.97935 -1.5406 10.9118 0 0 10.04 0 0 0 0 10.7175 6.58192 0 11.1003 Q6ZRN7 YP029_HUMAN Putative uncharacterized protein FLJ46214 Homo sapiens (Human) ECHGGPSPAAPRPLPGTSLTWPSR 1 11.5 0.80751 0.0084121 10.3164 0 0 0 0 0 0 0 0 0 0 0 Q6ZRP7 QSOX2_HUMAN Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1) QSOX2 QSCN6L1 SOXN Homo sapiens (Human) protein folding [GO:0006457] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] ALAGDVR;ESMDSVKTPDQAILWLWKK;LAGHLSEDPR;SELRGYPCSLWK;VELAAHK 5 7.9 0.96573 -1.2571 7.60028 0 0 9.004 11.0185 10.0208 0 0 0 7.55827 0 0 Q6ZRQ5 MMS22_HUMAN Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22L C6orf167 Homo sapiens (Human) chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297] cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] single-stranded DNA binding [GO:0003697] CIVQVIRKSYLEYK;EYMKQLVKLTR;HGVPDEMRKVESNWNFVEELLK;NEEMVQR;SLEYLGEVLKYIKPYLGK;WFVSESFWNWLNK 6 6.8 0.9734 -2.4749 6.14378 0 0 0 0 0 0 0 0 8.451 10.5544 0 Q6ZRR5 TLCD5_HUMAN TLC domain-containing protein 5 (Transmembrane protein 136) TLCD5 TMEM136 Homo sapiens (Human) membrane [GO:0016020] SYEWSCR 1 5.6 0.91109 -0.3203 5.44751 0 0 0 0 0 0 0 0 0 0 0 Q6ZRR7 LRRC9_HUMAN Leucine-rich repeat-containing protein 9 LRRC9 Homo sapiens (Human) cytoplasm [GO:0005737] FDDEVIK;HLDLSWNQLKK;LIKLKVLWLNHNTIK 3 2.3 0.94004 -0.57889 0 0 0 8.18854 0 0 0 0 7.05115 0 0 0 Q6ZRS2 SRCAP_HUMAN Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) SRCAP KIAA0309 Homo sapiens (Human) chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713] GQLREYQHIGLDWLVTMYEK;IDMGRFDLIGLEGR;IVCNMRTQFPDLR;LTLTGAQVR;SSAPPSLAGPAVSHR;VVRMVIR 6 2.4 0.96389 -1.192 14.1093 0 10.4369 2.18031 9.29799 11.761 0 0 0 8.38198 0 0 Q6ZRS4 ITPI1_HUMAN Protein ITPRID1 (Coiled-coil domain-containing protein 129) (ITPR-interacting domain-containing protein 1) ITPRID1 CCDC129 Homo sapiens (Human) signaling receptor binding [GO:0005102] ANNSAKDEK;ENLFQTNK;TICQSFR 3 2.3 0.97725 -2.1724 0 0 0 0 9.35643 0 0 11.2409 0 0 0 0 Q6ZRT6 PR23B_HUMAN Proline-rich protein 23B PRR23B Homo sapiens (Human) VPLDDVDLVLEPAPTSILR 1 7.2 0.7852 0.029165 0 0 0 0 0 0 0 0 0 0 8.55781 0 Q6ZRU5 YQ032_HUMAN Putative uncharacterized protein FLJ46089 Homo sapiens (Human) extracellular region [GO:0005576] ITPSACL;VGTYAVCWCSWNTGRFTGCPSWK 2 20.3 0.9544 -0.79951 0 0 11.1675 0 0 0 0 0 0 0 11.2124 0 Q6ZRV2 FA83H_HUMAN Protein FAM83H FAM83H Homo sapiens (Human) biomineral tissue development [GO:0031214]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell migration [GO:0030335]; protein localization to cytoskeleton [GO:0044380]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] keratin filament binding [GO:1990254]; protein kinase binding [GO:0019901] AVVSQAWREEVAAPGAVGGERR;ILGTFKSKK 2 2.6 0.87275 -0.10888 0 0 0 0 0 4.77014 10.2917 0 0 0 0 0 Q6ZRV3 CC074_HUMAN Putative uncharacterized protein encoded by LINC00696 LINC00696 C3orf74 Homo sapiens (Human) GKGALGF 1 4.3 0.71183 0.1567 7.56628 6.83378 0 0 0 9.68517 0 8.053 0 0 0 0 Q6ZRX8 YL004_HUMAN Putative uncharacterized protein FLJ45999 Homo sapiens (Human) SPTTGPQPNPR 1 6.5 0.7922 0.016459 0 0 0 3.09842 0 0 0 0 0 0 0 0 Q6ZS02 DMP46_HUMAN Putative GED domain-containing protein DNM1P46 (DNM1 pseudogene 46) DNM1P46 C15orf51 Homo sapiens (Human) AGTAARRDSR 1 4.5 0.97408 -1.4211 0 0 0 0 0 0 11.2922 0 0 0 0 0 Q6ZS11 RINL_HUMAN Ras and Rab interactor-like protein RINL Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EQTPQETEPEAAQRHDPAPRNPAPHGVSWVK;TLRAPELRR 2 7.1 0.96685 -1.2804 0 0 0 8.01229 0 7.82693 0 0 0 0 0 0 Q6ZS17 RIPR1_HUMAN Rho family-interacting cell polarization regulator 1 RIPOR1 FAM65A KIAA1930 Homo sapiens (Human) cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506] 14-3-3 protein binding [GO:0071889] FLEDALGQKLPR;HLYHCSRLLLKLGTFGPLR;LGFLYDLDK;QPGLAEAVCVK;VAGCLALGCIK;VMAAVSTQLR 6 5.9 0.97509 -3.2836 0 12.6187 0 0 8.37365 9.69253 0 11.7205 0 0 10.7184 0 Q6ZS27 ZN662_HUMAN Zinc finger protein 662 ZNF662 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GFMWNSDLSQHQR;ILNEQIFYICEECGK 2 6.6 0.91174 -0.32336 0 6.96694 0 0 0 0 0 12.4277 0 0 0 0 Q6ZS30 NBEL1_HUMAN Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] AIQLYLTCERGPWAK;ASESRLERNLVATFILIVK;GPWAKRK;ITISMNYVIGTHGWLPYDR;SPQELFKASGLTQKWVNR 5 2.8 0.96615 -1.1259 10.3887 0 4.73031 7.12526 0 9.15763 8.83156 0 11.9092 0 0 0 Q6ZS46 YF009_HUMAN Putative uncharacterized protein FLJ45840 Homo sapiens (Human) AGLPEGK 1 3.2 0.64688 0.17138 0 0 0 0 0 0 0 0 10.2075 0 0 0 Q6ZS49 YQ050_HUMAN Putative uncharacterized protein FLJ45831 Homo sapiens (Human) extracellular space [GO:0005615] LMPYYLFHRSR 1 9.1 0.88797 -0.18448 0 0 0 0 0 0 0 0 0 0 7.539 0 Q6ZS52 YF013_HUMAN Putative uncharacterized protein FLJ45825 Homo sapiens (Human) AGGGEAGSRPPR;VVAEQPVGGTDPPAHGGR 2 18.9 0.93388 -0.51199 0 0 0 0 0 0 0 12.5942 0 0 8.93434 0 Q6ZS62 COLC1_HUMAN Colorectal cancer-associated protein 1 COLCA1 C11orf92 Homo sapiens (Human) membrane [GO:0016020] ESCSVAQAGVLTSPFMWR 1 14.5 0.78324 0.022981 6.61628 0 0 0 0 0 0 0 0 0 0 0 Q6ZS72 PEAK3_HUMAN Protein PEAK3 PEAK3 C19orf35 Homo sapiens (Human) regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360] actin cytoskeleton [GO:0015629]; focal adhesion [GO:0005925] protein kinase activity [GO:0004672] QLQGLRTIYARLR 1 2.7 0.6077 0.17604 0 2.96724 0 0 0 0 0 0 0 0 0 0 Q6ZS81 WDFY4_HUMAN WD repeat- and FYVE domain-containing protein 4 WDFY4 C10orf64 KIAA1607 Homo sapiens (Human) "antigen processing and presentation [GO:0019882]; autophagy [GO:0006914]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cellular response to virus [GO:0098586]" early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783] AWQHYLASEK;DRSTDHYSCQCHSYADMR;GDWGLSSAYR;GQELYASLYK;HKESQDK;IVVTLLKGSVRNAVVLK;KFLEYQQLTHKSPIER;RRGQELYASLYK;VTLWSGSLSSAMK 9 3.2 0.9747 -3.0942 11.9756 0 10.0913 9.3064 10.3961 0 6.17329 10.8122 7.41811 0 10.1649 0 Q6ZS92 YD022_HUMAN Putative uncharacterized protein FLJ45721 Homo sapiens (Human) NTFVVPDSISR 1 6.7 0.93346 -0.50615 0 0 0 0 0 0 11.1335 0 0 0 0 0 Q6ZSA8 YS025_HUMAN Putative uncharacterized protein FLJ45684 Homo sapiens (Human) VCVSPLGQVTRIPPVRTVR 1 14.5 0.85818 -0.081391 0 0 0 6.01692 0 0 0 0 0 0 0 0 Q6ZSB3 CB046_HUMAN Putative uncharacterized protein encoded by LINC00299 LINC00299 C2orf46 NCRNA00299 Homo sapiens (Human) DNFEGGCLAELIGSPR 1 11.5 0.58982 0.17858 0 0 0 0 0 0 0 0 5.7067 0 0 0 Q6ZSB9 ZBT49_HUMAN Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]" LVKHRIR;SLFQNSSSQK 2 2.2 0.83674 -0.030557 0 0 0 0 0 0 0 0 0 0 0 7.14405 Q6ZSB9 ZBT49_HUMAN Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]" REMFWGIR;SLFQNSSSQK 2 3.9 0.95136 -0.69364 4.02441 3.31829 0 0 0 0 0 0 0 0 0 9.96924 Q6ZSC3 RBM43_HUMAN RNA-binding protein 43 (RNA-binding motif protein 43) RBM43 C2orf38 Homo sapiens (Human) RNA binding [GO:0003723] GVAYVIFKEKK 1 3.1 0.76994 0.056506 0 0 0 0 0 0 13.7352 0 0 7.06242 0 0 Q6ZSG1 ARK2C_HUMAN E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165) ARK2C RNF165 Homo sapiens (Human) forelimb morphogenesis [GO:0035136]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; positive regulation of BMP signaling pathway [GO:0030513]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209] nucleus [GO:0005634]; protein-containing complex [GO:0032991] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] RSQERVSVHPHR 1 3.5 0.86819 -0.093371 0 0 0 0 0 0 0 4.44248 0 0 0 0 Q6ZSG2 INSY2_HUMAN Inhibitory synaptic factor 2A (InSyn2) INSYN2A C10orf141 FAM196A INSYN2 Homo sapiens (Human) inhibitory postsynaptic potential [GO:0060080] postsynaptic density [GO:0014069] ALQVRFK;EAKPVSCRAAYRK 2 4.2 0.97341 -1.4162 0 0 0 0 0 0 0 0 0 0 0 7.36326 Q6ZSI9 CAN12_HUMAN Calpain-12 (EC 3.4.22.-) (Calcium-activated neutral proteinase 12) (CANP 12) CAPN12 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] KEDGEFWMELR;TPKCTVLLSLIQRNR 2 3.6 0.12757 0.35763 3.25577 0 0 0 0 5.06953 4.43022 4.09271 0 0 0 0 Q6ZSJ9 SHSA6_HUMAN Protein shisa-6 SHISA6 Homo sapiens (Human) excitatory chemical synaptic transmission [GO:0098976]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] "AMPA glutamate receptor complex [GO:0032281]; asymmetric, glutamatergic, excitatory synapse [GO:0098985]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]" ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165] AGGALAR;EFECNNSESGYLYCCGTCYYRFCCK;QTPGHYGK 3 7.3 0.93735 -0.57657 0 0 13.6227 0 0 0 13.1758 10.6923 0 0 7.70446 0 Q6ZSR9 YJ005_HUMAN Uncharacterized protein FLJ45252 Homo sapiens (Human) IVSQTNK;TVQGGRK;VPGTKTQNNLESDYLAR 3 8.7 0.9785 -1.5305 0 0 0 9.92362 9.5623 9.57996 11.4758 11.1559 11.8152 0 7.9735 12.2094 Q6ZSS3 ZN621_HUMAN Zinc finger protein 621 ZNF621 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FYECKECGK;IFRYNSK;LIRHQMSHTGEKPFK 3 7.1 0.98049 -1.6387 0 0 0 0 4.91781 5.95236 0 7.62352 0 0 0 0 Q6ZST4 LCNL1_HUMAN Lipocalin-like 1 protein LCNL1 Homo sapiens (Human) small molecule binding [GO:0036094] MAVVLVTPLGNGDLALK 1 10.4 0.84087 -0.047895 0 0 0 0 0 12.6798 0 0 0 0 12.5538 0 Q6ZSY5 PPR3F_HUMAN Protein phosphatase 1 regulatory subunit 3F (R3F) PPP1R3F Homo sapiens (Human) regulation of glycogen (starch) synthase activity [GO:2000465]; regulation of glycogen biosynthetic process [GO:0005979] membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164] glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903] YRPWGGPGAGK 1 1.4 0.91628 -0.43228 0 0 0 0 0 0 0 0 0 0 0 11.7623 Q6ZSZ5 ARHGI_HUMAN Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) ARHGEF18 KIAA0521 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] DKGQDARER;DSAPTENRLAK;DSLFSSLAGSQDLSR;SRSCSESWR;STSVKRR 5 3.7 0.97427 -3.7885 0 0 0 0 6.81455 9.2286 0 13.2797 0 8.81618 8.5529 0 Q6ZSZ5 ARHGI_HUMAN Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) ARHGEF18 KIAA0521 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] DSAPTENRLAK;EDAALFSRRIPPR 2 2 0.95694 -1.023 0 0 0 0 0 0 0 0 0 9.2761 0 0 Q6ZSZ6 TSH1_HUMAN Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) TSHZ1 SDCCAG33 TSH1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; middle ear morphogenesis [GO:0042474]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EESEDSLEK;VPLKEPVPAITKLVPSTK 2 2.5 0.95071 -0.66877 0 0 0 0 0 0 0 0 0 0 6.21288 0 Q6ZT07 TBCD9_HUMAN TBC1 domain family member 9 (TBC1 domain family member 9A) TBC1D9 KIAA0882 TBC1D9A Homo sapiens (Human) calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] DDSSMSSYSVLSAGSHEEDK;RSPEEFNPK;TSYEKFGTIR 3 3.1 0.97459 -1.4249 0 0 0 0 0 0 5.00997 0 0 0 0 0 Q6ZT12 UBR3_HUMAN E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) UBR3 KIAA2024 ZNF650 Homo sapiens (Human) embryo development ending in birth or egg hatching [GO:0009792]; in utero embryonic development [GO:0001701]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; olfactory behavior [GO:0042048]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; sensory perception of smell [GO:0007608]; suckling behavior [GO:0001967]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] cytoplasm [GO:0005737]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DLTSGLGENACVK;IIEEICR;MGGAMRSVLTQVLTNQQNYK;SEIILCQYR;THSSLLDLIPENPNPK 5 3.4 0.97691 -1.4951 0 0 0 10.6765 0 0 0 9.23647 0 9.8878 0 0 Q6ZT21 TMPPE_HUMAN Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-) TMPPE Homo sapiens (Human) membrane [GO:0016020] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] LVLRPALAVGVTAVLSVAGILNAAQPPAVK 1 6.6 0.71312 0.14555 7.41844 0 0 0 0 0 5.74994 8.02176 0 6.58028 6.42782 0 Q6ZT52 FA43B_HUMAN Protein FAM43B FAM43B Homo sapiens (Human) GAPAPPPPAQPR;LLNAKCAYRPPPSER 2 8.2 0.98156 -1.5787 0 0 0 9.06983 8.73501 8.94181 0 0 0 0 0 0 Q6ZT77 ZN826_HUMAN Putative zinc finger protein 826 ZNF826P ZNF826 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] NAINGIK;TIHTGEKPCK 2 9.6 0.96341 -1.0986 0 0 0 0 0 0 0 0 0 0 11.0146 0 Q6ZT98 TTLL7_HUMAN Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7) TTLL7 Homo sapiens (Human) cell differentiation [GO:0030154]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; perikaryon [GO:0043204] "alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" AEAQRRLYGQNSIK;GVLLNALKLLNIR;IFLYHDGLVR;LDSVKQRK;YCSSDSSYDSSSSSSESDENEK 5 7.6 0.97246 -1.3654 0 6.39141 7.64796 0 0 4.81778 3.65718 10.5897 0 0 0 4.03492 Q6ZTA4 TRI67_HUMAN Tripartite motif-containing protein 67 (TRIM9-like protein) TRIM67 TNL Homo sapiens (Human) negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of protein localization [GO:0032880] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] zinc ion binding [GO:0008270] ETLCTIDGLHFNSTYNAR 1 2.3 0.78212 0.022541 0 0 0 0 0 0 0 0 0 0 5.54668 0 Q6ZTI0 YK032_HUMAN Putative uncharacterized protein FLJ44636 Homo sapiens (Human) SQEEAAPPSPRPQSR 1 12.2 0.77955 0.035336 0 0 0 0 0 0 0 0 0 9.3758 0 0 Q6ZTK2 YP015_HUMAN Putative uncharacterized protein LOC400499 Homo sapiens (Human) EGKIQVYTAATTYLR;IQVYTAATTYLR;LVTGGSPVVFTGNLTRQVGSK;QDRTLYRK;VQLWHEEDSGHLHSQLEVSYGKQWDK 5 12.7 0.9539 -0.91662 0 0 0 0 0 0 6.32571 0 12.6745 0 10.9367 0 Q6ZTN6 AN13D_HUMAN Ankyrin repeat domain-containing protein 13D ANKRD13D Homo sapiens (Human) negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] LRDFITLRLPPGFPVK;SEKMETVSGYEAK 2 4.8 0.92185 -0.44681 0 0 0 0 0 0 0 8.32278 0 0 0 0 Q6ZTQ3 RASF6_HUMAN Ras association domain-containing protein 6 RASSF6 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165] ISELDRTQIPMSEKR;TQIPMSEK 2 4.1 0.9287 -0.47148 0 0 0 0 0 7.02547 0 0 0 0 0 0 Q6ZTQ4 CDHR3_HUMAN Cadherin-related family member 3 (Cadherin-like protein 28) CDHR3 CDH28 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; virus receptor activity [GO:0001618] DRPYGGQENR;INQLTGTIQVAQRIDR 2 9.4 0.91732 -0.41215 0 0 5.80444 0 0 0 0 8.65864 0 0 0 0 Q6ZTR5 CFA47_HUMAN Cilia- and flagella-associated protein 47 CFAP47 CHDC2 CXorf22 CXorf30 CXorf59 Homo sapiens (Human) cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212] ANGKYWPIDNFDELDIK;DEDTFDR;DFPDFSMDLKDK;FLPFNMHVRYCVIILSNKK;GIAFSICPAK;GKVLDFK;GNIDISLLFIPQIMKLHK;HDCSLMLTPK;HHVTWTLDLSNTGK;IECVTEGIWK;IETLMLFRISKLR;ILLKNSSSR;KDIGPSYR;LFKDGTFK;NEINVTLKFTSRFIRPAEASLLLISKPK;RAWTDVFLQIYK;TANFEIDPEKGK;VTKTQNLVLYNITK 18 7.2 0.97844 -6.6614 6.8212 13.1025 11.3262 11.6995 10.3844 10.7278 12.3125 11.1181 11.6887 15.0386 15.1766 10.9307 Q6ZTR6 ZNFDT_HUMAN Putative uncharacterized protein ZNF516-DT (ZNF516 divergent transcript) ZNF516-DT C18orf65 Homo sapiens (Human) AGDQTGGAFCMCDVSGGGGECVSGSGGGGESGRK;IVLLLLVITPQWR;TPNVAPR 3 33.1 0.8442 -0.055269 5.60538 8.23237 3.75082 0 0 0 6.84361 0 0 0 0 0 Q6ZTR7 CBAR2_HUMAN CBY1-interacting BAR domain-containing protein 2 (Protein FAM92B) CIBAR2 FAM92B Homo sapiens (Human) cilium assembly [GO:0060271] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737] VVNPLKLYGAQIKQTR 1 5.3 0.84937 -0.079067 0 0 0 6.93156 0 0 0 0 0 0 0 0 Q6ZTU2 E400N_HUMAN Putative EP400-like protein (EP400 pseudogene 1) EP400P1 EP400NL Homo sapiens (Human) LSSLGFEDSMC 1 3.1 0.80841 0.010882 0 5.48913 0 0 0 0 0 0 0 0 0 0 Q6ZTZ1 MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 MSANTD1 C4orf44 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893] nuclear body [GO:0016604] LLEAMVEEQRR;LSRAVEETCR;LSRAVEETCREVR;QLRLLEAMVEEQRR 4 9.7 0.95544 -0.86734 0 11.1415 0 0 3.78983 0 7.67469 0 0 0 9.87708 0 Q6ZU15 SEP14_HUMAN Septin-14 SEPTIN14 SEPT14 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; neuron migration [GO:0001764]; protein localization [GO:0008104]; protein localization to perinuclear region of cytoplasm [GO:1905719]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; axon [GO:0030424]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ADTISKNDLQTFK;QEFYDQCQREEEELK;VNIIPLIAK 3 8.6 0.95114 -0.68639 0 0 0 0 5.23829 0 0 9.80777 0 0 0 10.7611 Q6ZU35 CRACD_HUMAN Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) CRACD CRAD KIAA1211 Homo sapiens (Human) epithelial structure maintenance [GO:0010669]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838] cytosol [GO:0005829] EDQESSDR;QEDYWRELEAK 2 1.5 0.97828 -1.9794 0 0 0 0 5.70133 0 0 0 12.5967 0 0 0 Q6ZU45 CL20A_HUMAN Putative C-type lectin domain family 20 member A CLEC20A Homo sapiens (Human) carbohydrate binding [GO:0030246] LHYTDLADLQPSGLWK 1 4 0.93748 -0.56041 0 0 0 10.8355 0 0 0 0 0 0 0 0 Q6ZU52 K0408_HUMAN Uncharacterized protein KIAA0408 KIAA0408 Homo sapiens (Human) NFPSSDSEQAYERWK;NYNPHFPLRQQEMSMLYPNEGKTSK 2 5.8 0.97497 -1.3844 12.3589 0 0 0 0 0 0 0 0 6.88435 0 0 Q6ZU64 CFA65_HUMAN Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108) CFAP65 CCDC108 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] RNA binding [GO:0003723] DCKLLTFSLAPQR;EYMDQLWFEK;GEEEEEELEEEEEEEEETEEEELGK;LPLQFEWR;LPLQFEWRVSEQHR;QFWNEQSTKFMDQK;TVDYCSIMPSGCASK;VIWGIEVAEELHWKGWELGK 8 5.8 0.97664 -2.1924 0 9.26505 0 9.91601 6.53367 7.47452 0 0 0 8.8157 10.9833 6.51898 Q6ZU65 UBN2_HUMAN Ubinuclein-2 UBN2 KIAA2030 Homo sapiens (Human) chromatin organization [GO:0006325] extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EAEYPGPEREPEYPR;EPEYPREPPR;VAAKLFDEEGRK;YKDSLSLAAMIRK 4 3.3 0.9727 -2.6661 0 0 12.7522 7.21237 0 0 8.8125 0 0 0 9.6858 0 Q6ZU67 BEND4_HUMAN BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) BEND4 CCDC4 Homo sapiens (Human) DNA binding [GO:0003677] RPLDPVK 1 1.3 0.90875 -0.30924 0 0 0 0 0 12.4239 0 0 0 0 0 0 Q6ZU69 S31F1_HUMAN Protein SPATA31F1 (Protein FAM205A) SPATA31F1 C9orf144B FAM205A Homo sapiens (Human) membrane [GO:0016020]; nucleus [GO:0005634] AQSRPAQK;ELSLSSVTPTLSQLTDQK;KKVLEIQWGIPIR;LLEFHIQK;SCCRCHQK 5 4.1 0.97541 -3.1728 0 0 0 0 0 0 0 0 0 10.5995 10.0534 0 Q6ZU80 CE128_HUMAN Centrosomal protein of 128 kDa (Cep128) CEP128 C14orf145 C14orf61 Homo sapiens (Human) protein localization [GO:0008104]; regulation of gene expression [GO:0010468]; sperm flagellum assembly [GO:0120316] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] DLSAIRADLANK;GVEREKQDLEK;LKLKYQCLK;VNTITSTLQDTSR 4 4.1 0.97674 -4.8093 0 12.9309 0 0 9.61596 9.71848 0 0 0 0 0 10.7373 Q6ZU80 CE128_HUMAN Centrosomal protein of 128 kDa (Cep128) CEP128 C14orf145 C14orf61 Homo sapiens (Human) protein localization [GO:0008104]; regulation of gene expression [GO:0010468]; sperm flagellum assembly [GO:0120316] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] DNEILTYSLQSPLHV;GVEREKQDLEK;VNTITSTLQDTSR 3 9 0.93428 -0.5034 0 8.45422 0 0 0 0 0 0 0 9.07385 0 0 Q6ZUA9 MROH5_HUMAN Maestro heat-like repeat family member 5 MROH5 Homo sapiens (Human) cytoplasm [GO:0005737] DRQCSERPYSCTPTGR;EFATSQLSFLQKVSARPKQ;LALENMTK;LLHTLFCTLAWER;SQLLSTCFR;WKWASSTILLAYGQVAAKAR 6 6.4 0.97473 -3.9319 0 7.09698 0 0 0 0 12.821 12.5942 0 14.01 0 11.3357 Q6ZUB0 S31D4_HUMAN Spermatogenesis-associated protein 31D4 (Protein FAM75D4) SPATA31D4 FAM75D4 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] LEWQHIHQQPPYSK;RGDFLMWK;SLQKEAEEERK 3 3.6 0.97956 -1.8469 0 12.4576 0 10.3522 0 0 0 0 0 0 13.5242 0 Q6ZUB1 S31E1_HUMAN Spermatogenesis-associated protein 31E1 (Protein FAM75E1) SPATA31E1 C9orf79 FAM75E1 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] AHQPHGK;ALACSPKATPK;SHPAQAR;SWLMAKCAVPKSDTHR;TQSVIPTGKEYLEWPLKK 5 4.1 0.97468 -3.2426 8.72093 0 11.697 9.56127 0 0 11.3828 0 8.02259 0 0 0 Q6ZUI0 TPRG1_HUMAN Tumor protein p63-regulated gene 1 protein (Protein FAM79B) TPRG1 FAM79B Homo sapiens (Human) cytoplasm [GO:0005737] FTFPGMSLDK 1 3.6 0.89795 -0.23338 0 0 0 0 0 0 0 0 0 8.01128 0 0 Q6ZUJ4 CC062_HUMAN Uncharacterized protein C3orf62 C3orf62 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] HYIKTWSLLGEMSEKLR;LELSAAPLSFSLPVHRLLCR 2 13.9 0.66037 0.16899 0 0 0 8.40305 0 0 0 0 0 0 7.85368 0 Q6ZUJ8 BCAP_HUMAN Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; signaling receptor binding [GO:0005102] AASGVPR;SQKILTHR;VEFGVYESGPRK 3 3.4 0.9664 -1.2719 0 0 0 14.8418 14.9124 15.095 0 0 0 15.1706 0 0 Q6ZUL3 CH086_HUMAN Uncharacterized protein LINC03042 (Long intergenic non-protein coding RNA 3042) LINC03042 C8orf86 Homo sapiens (Human) TERQRTGSSK;WREPPPR 2 7.6 0.97249 -2.8157 0 0 0 0 0 0 12.0221 0 0 0 0 0 Q6ZUM4 RHG27_HUMAN Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) ARHGAP27 CAMGAP1 SH3D20 PP905 Homo sapiens (Human) protein heterooligomerization [GO:0051291]; receptor-mediated endocytosis [GO:0006898]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] DLVRSLPAPNHDTLR;ISGNLATIQKLRYK;LGSWQEK;VIEHGEQNR 4 5.1 0.95401 -0.89041 8.25072 7.76885 13.313 0 0 0 0 8.17013 0 0 0 0 Q6ZUS5 CC121_HUMAN Coiled-coil domain-containing protein 121 CCDC121 Homo sapiens (Human) ELNMKAQALK;LAAKRFIFEYSCGINR;QDVPKTTPSLPQGTK 3 14.7 0.78014 0.033541 0 0 7.85947 0 0 0 0 11.4992 0 0 0 0 Q6ZUS6 CC149_HUMAN Coiled-coil domain-containing protein 149 CCDC149 Homo sapiens (Human) LLRMTIAKQR;MVVIVVVIIIIIAR 2 4.5 0.96581 -1.1268 0 0 0 0 0 0 0 4.20649 0 0 0 0 Q6ZUS6 CC149_HUMAN Coiled-coil domain-containing protein 149 CCDC149 Homo sapiens (Human) TIAKQRLGDEAIGVR 1 3.7 0.4269 0.19671 0 0 0 0 0 0 0 0 0 0 0 5.99358 Q6ZUT1 NKAP1_HUMAN Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) NKAPD1 C11orf57 Homo sapiens (Human) identical protein binding [GO:0042802] IPLGKVLLRNVIR;SAESSEDD 2 7.2 0.25228 0.27752 0 0 0 0 0 2.72227 5.19535 8.32139 0 0 0 0 Q6ZUT3 FRMD7_HUMAN FERM domain-containing protein 7 FRMD7 Homo sapiens (Human) negative regulation of stress fiber assembly [GO:0051497]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of neuron projection development [GO:0010975] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DACKAFWK;FSGNHMSIYSGLTSK;GNTKINTFNWAK 3 4.9 0.97266 -2.673 0 0 0 0 0 0 0 12.8224 0 0 0 0 Q6ZUT4 YL014_HUMAN Putative uncharacterized protein FLJ43343 Homo sapiens (Human) LLENQAR 1 5.5 0.83616 -0.034429 0 0 0 0 0 0 0 0 0 0 9.64649 0 Q6ZUT9 DEN5B_HUMAN DENN domain-containing protein 5B (Rab6IP1-like protein) DENND5B Homo sapiens (Human) positive regulation of triglyceride transport [GO:1905885] cytosol [GO:0005829]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] FVEGLLKECR;HFHKPEK;MDLSASLGEKDK;SALWSHLIQFQDREEK;TFCHYVNAINTAPR;YNSYDISR 6 5.3 0.98095 -1.6955 0 0 0 0 10.1981 0 0 0 0 0 6.74376 0 Q6ZUU3 FOXNB_HUMAN FOXL2 neighbor protein FOXL2NB C3orf72 Homo sapiens (Human) fibrillar center [GO:0001650] CLASKGK 1 4 0.899 -0.2574 0 0 0 0 0 0 0 0 0 10.1406 0 0 Q6ZUX3 TGRM2_HUMAN TOG array regulator of axonemal microtubules protein 2 (Crescerin-2) TOGARAM2 FAM179A Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904] cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881] microtubule binding [GO:0008017] DFRSRMEGVGQLLELCK;EACPPLKEEDQK;EKMQLKQMK;LAACHSEVLTGK 4 4.9 0.9785 -1.942 0 2.93017 0 0 8.48671 0 0 2.30617 0 8.15208 10.2606 0 Q6ZV29 PLPL7_HUMAN Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) PNPLA7 C9orf111 Homo sapiens (Human) phosphatidylcholine catabolic process [GO:0034638] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] lysophospholipase activity [GO:0004622] LAGEYGR;NVRVLGHFEKPLFLELCK;SDCTYIMLSGRLRSVIR;TVEWLNMR 4 3.8 0.98053 -1.6173 0 0 0 0 0 0 9.03023 0 0 6.209 11.0771 0 Q6ZV50 RFX8_HUMAN DNA-binding protein RFX8 (Regulatory factor X 8) RFX8 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVRLVFPDLGTRR;WNLLLTAVSKAMTLCHR 2 5.1 0.93649 -0.52341 0 0 0 0 3.28499 0 0 0 11.726 0 0 0 Q6ZV60 YL023_HUMAN Putative uncharacterized protein encoded by LINC00173 LINC00173 NCRNA00173 Homo sapiens (Human) GVCQGWHCVKK 1 7.7 0.86527 -0.090217 0 0 0 0 0 8.43509 0 0 0 0 0 0 Q6ZV65 FA47E_HUMAN Protein FAM47E FAM47E Homo sapiens (Human) protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] enzyme activator activity [GO:0008047] FPTSLHSRQLVFPRK;KELQEQEELLADLHGTVAFK;LLKKHSTQVYLGPSK;LQETEFFQK;VLEVLDPDR 5 17.3 0.91498 -0.33474 7.34997 11.4311 0 0 9.33042 0 11.3972 0 0 0 0 0 Q6ZV73 FGD6_HUMAN "FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)" FGD6 KIAA1362 ZFYVE24 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] ASVLEEELK;DLGPLEIHLVPYTPKFPTPKPR;GVSSSFDMPK;IVPKKPQRHSLPATGVLK;KMKPAIAPKPKVLK;MAPSFDK;NKVLYTYAASEVR;NQPARVCEHCFQELQK;TSAAEIK 9 8.4 0.97494 -3.6892 0 8.33985 0 6.32247 8.98783 0 11.4703 10.2283 8.53722 8.80986 10.5602 8.67221 Q6ZV77 CI139_HUMAN Putative uncharacterized protein LINC02908 (Long intergenic non-protein coding RNA 2908) LINC02908 C9orf139 Homo sapiens (Human) SGGRGSPSSHPTQAS 1 7.9 0.88248 -0.17082 0 8.35826 0 0 0 0 0 0 0 0 0 0 Q6ZV80 CB091_HUMAN Putative uncharacterized protein LINC02898 (Long intergenic non-protein coding RNA 2898) LINC02898 C2orf91 Homo sapiens (Human) QQTALHCPFDFPQAPLR 1 13 0.86912 -0.096865 0 0 0 9.80678 9.96564 0 0 0 0 0 0 0 Q6ZV89 SH2D5_HUMAN SH2 domain-containing protein 5 SH2D5 Homo sapiens (Human) postsynaptic density [GO:0014069] RILYSTWCPADCQFAFMAR 1 4.5 0.32414 0.24582 0 0 0 0 9.37617 0 0 0 0 0 0 0 Q6ZVC0 NYAP1_HUMAN Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 NYAP1 C7orf51 Homo sapiens (Human) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] GERELPNSHSMICPK;MGFMTMPASQEHTPHPCR 2 3.9 0.91673 -0.41515 0 10.3405 0 0 0 0 7.72342 0 0 0 0 0 Q6ZVD7 STOX1_HUMAN Storkhead-box protein 1 (Winged-helix domain-containing protein) STOX1 C10orf24 Homo sapiens (Human) cell division [GO:0051301]; cellular response to nitrosative stress [GO:0071500]; inner ear development [GO:0048839]; negative regulation of gene expression [GO:0010629]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of otic vesicle morphogenesis [GO:1904120]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of gene expression [GO:0010468]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of response to oxidative stress [GO:1902882]; regulation of transcription by RNA polymerase II [GO:0006357] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] LEKHPKLPATQPIPR;QDKDSEELLR;RISNPFQGLSHR;RQGLSAKPQGQGHSRR 4 5.4 0.97334 -1.3724 0 0 0 9.77414 0 0 0 8.04707 0 7.86177 0 10.6865 Q6ZVD8 PHLP2_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) PHLPP2 KIAA0931 PHLPPL Homo sapiens (Human) hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] ERDWLREDVK;HLQDFPGEDK;NLLECVPDWACEAKK 3 3.7 0.95372 -0.91725 0 0 0 0 0 0 0 7.71122 12.7064 6.39 0 0 Q6ZVE7 GOT1A_HUMAN Vesicle transport protein GOT1A (Golgi transport 1 homolog A) (hGOT1b) GOLT1A GOT1B Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; trans-Golgi network [GO:0005802] HKLKGTSFLLGGVVIVLLR;KTFWFFFQRHK 2 21.2 0.75372 0.075397 0 0 0 0 0 0 0 0 0 5.34006 0 9.76876 Q6ZVH7 ESPNL_HUMAN Espin-like protein ESPNL Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; sensory perception of sound [GO:0007605] cytoplasm [GO:0005737]; stereocilium tip [GO:0032426] actin filament binding [GO:0051015] ARFFGSSQRPAWDTEPGRK;SLSLLLK 2 2.6 0.13689 0.35411 0 0 0 6.90292 0 0 9.67083 11.457 0 0 0 0 Q6ZVK1 T179A_HUMAN Transmembrane protein 179 (Transmembrane protein 179A) TMEM179 C14orf90 TMEM179A Homo sapiens (Human) membrane [GO:0016020] FTVQEWGPPAACR 1 5.6 0.79528 0.015324 0 0 0 0 0 0 0 0 10.1198 0 0 0 Q6ZVK8 NUD18_HUMAN "8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)" NUDT18 MTH3 Homo sapiens (Human) dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule metabolic process [GO:0055086] cytosol [GO:0005829] 8-hydroxy-dADP phosphatase activity [GO:0044717]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; metal ion binding [GO:0046872] GENFSWWK 1 2.5 0.91353 -0.39033 0 0 0 0 0 0 0 0 0 0 0 9.3661 Q6ZVL6 K154L_HUMAN UPF0606 protein KIAA1549L KIAA1549L C11orf41 C11orf69 Homo sapiens (Human) membrane [GO:0016020] ASPSSMDVYDSLTIGDMK;LLVKTVLFLTQRR;SSSMTTLAK;TAKSTETRK;VLRASQHPK;VPEPRGYSRSR 6 3.7 0.97481 -3.2474 11.3904 11.4407 7.17901 0 9.72279 0 0 0 0 8.45607 0 0 Q6ZVL8 YP033_HUMAN Putative uncharacterized protein FLJ42384 Homo sapiens (Human) LVGRASPR 1 5.7 0.98043 -1.6133 0 0 0 0 0 0 0 0 0 0 11.6031 0 Q6ZVM7 TM1L2_HUMAN TOM1-like protein 2 (Target of Myb-like protein 2) TOM1L2 Homo sapiens (Human) negative regulation of mitotic nuclear division [GO:0045839]; protein transport [GO:0015031]; signal transduction [GO:0007165] endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020] clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] TVTYEDPQAVGGLASALDNR;VLALIQAWADAFR 2 6.5 0.90883 -0.31308 0 10.1492 0 0 9.39652 0 10.4858 0 0 0 0 0 Q6ZVN7 SEML_HUMAN "Putative protein SEM1, isoform 2" SEM1 C7orf76 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724] proteasome complex [GO:0000502] GRRPSIR 1 5.5 0.98036 -1.6404 0 0 0 0 0 0 0 0 0 0 9.13661 0 Q6ZVN8 RGMC_HUMAN Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C) HJV HFE2 RGMC Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; transcription by RNA polymerase II [GO:0006366] BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; side of membrane [GO:0098552] BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] GGGGGGR;LSRSERNR 2 3.5 0.96527 -1.2541 0 0 0 0 0 0 0 0 11.0373 0 0 0 Q6ZVT0 TTL10_HUMAN Inactive polyglycylase TTLL10 (Tubulin--tyrosine ligase-like protein 10) TTLL10 Homo sapiens (Human) protein modification process [GO:0036211] cytosol [GO:0005829] ATP binding [GO:0005524]; protein-glycine ligase activity [GO:0070735] IQQRPRARVSGTIPASR;LLTTKIGLLSTLR;TPFRGPQARVVQR 3 6.4 0.90758 -0.30581 6.24962 0 0 0 0 8.71644 0 0 0 6.64544 0 8.08295 Q6ZVT6 CF20D_HUMAN Protein CFAP20DC (Uncharacterized protein C3orf67) CFAP20DC C3orf67 Homo sapiens (Human) TPEPVIK 1 1 0.64815 0.17077 0 0 0 0 0 0 0 0 0 0 7.36728 0 Q6ZVX7 FBX50_HUMAN F-box only protein 50 (NCC receptor protein 1 homolog) (NCCRP-1) (Non-specific cytotoxic cell receptor protein 1 homolog) NCCRP1 FBXO50 Homo sapiens (Human) ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; positive regulation of cell population proliferation [GO:0008284]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; SCF ubiquitin ligase complex [GO:0019005] LLLLRRPLYRNLLR 1 5.1 0.58655 0.17944 0 0 0 0 0 0 0 5.98918 5.42643 0 0 0 Q6ZW05 PTHD4_HUMAN Patched domain-containing protein 4 (p53-regulated patched protein) PTCHD4 C6orf138 PTCH53 Homo sapiens (Human) membrane [GO:0016020] VSNVSANNKSDFISVLQSSFLK 1 2.6 0.98014 -1.5569 0 0 0 0 0 0 0 0 0 0 0 11.1111 Q6ZW13 CP086_HUMAN Uncharacterized protein C16orf86 C16orf86 Homo sapiens (Human) KPVKSLSLPGLRAHLK 1 5 0.50295 0.18857 0 0 3.95531 0 0 0 0 0 0 0 0 0 Q6ZW31 SYDE1_HUMAN Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) SYDE1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of cytoskeleton organization [GO:0051493]; regulation of Ras protein signal transduction [GO:0046578]; signal transduction [GO:0007165] synaptic membrane [GO:0097060] GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695] AGRERER;ELRDAFER;HRPCAQGTVLLPTVFR;QPPLHLPLADPEVVTRPRGR;QSPDVAPYLRPK 5 8.6 0.98143 -1.7062 0 0 7.27836 7.40625 7.06361 0 8.83494 0 12.0671 9.96939 0 0 Q6ZW49 PAXI1_HUMAN PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 PAXIP1L PTIP CAGF28 Homo sapiens (Human) "adipose tissue development [GO:0060612]; chorion development [GO:0060717]; chromatin remodeling [GO:0006338]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; endothelial cell migration [GO:0043542]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of isotype switching [GO:0045830]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of cell cycle G2/M phase transition [GO:1902749]; response to ionizing radiation [GO:0010212]; vasculogenesis [GO:0001570]" chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] CTHLIASKVTRTVK;GELMFDDSSDSSPEK;GNLMAAGQNLQSSER;MSDQAPK;VTRTVKFLTAISVVK 5 5.6 0.93725 -0.5417 7.54612 0 8.2811 0 0 0 0 0 10.3561 0 0 3.57797 Q6ZW61 BBS12_HUMAN Chaperonin-containing T-complex member BBS12 (Bardet-Biedl syndrome 12 protein) BBS12 C4orf24 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; fat cell differentiation [GO:0045444]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; stem cell differentiation [GO:0048863] cilium [GO:0005929] ATP binding [GO:0005524] LNSRIFNSDISNKLEQIPR;TVLDSMR 2 3.7 0.95185 -0.7451 0 13.8918 0 0 0 0 0 0 0 0 0 0 Q6ZWB6 KCTD8_HUMAN BTB/POZ domain-containing protein KCTD8 KCTD8 Homo sapiens (Human) protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235] identical protein binding [GO:0042802] LLREAEYFQLTDLVK;QWQSELLQK;VARIMVCGR;VCEKLSVEEEMKK 4 9.7 0.97706 -2.231 0 0 0 0 0 9.37467 0 0 0 0 7.74261 0 Q6ZWE6 PKHM3_HUMAN Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) PLEKHM3 DAPR PLEKHM1L Homo sapiens (Human) myoblast differentiation [GO:0045445] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] GFICEICNNGEILYPFEDISTSRCESCGAVFHSECK;LAPFLGK;QKSFWQR 3 6.6 0.97239 -1.3657 0 11.2432 0 0 0 11.2892 0 0 0 0 0 11.0972 Q6ZWH5 NEK10_HUMAN Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10) NEK10 Homo sapiens (Human) mucociliary clearance [GO:0120197]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein autophosphorylation [GO:0031954]; protein phosphorylation [GO:0006468]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of ERK1 and ERK2 cascade [GO:0070372] extracellular region [GO:0005576]; protein kinase complex [GO:1902911] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HHHFTEERLWK;KVRQISDPIQQILIQLHK;LFQEIFTALVK;LILPNKQK;VPPHMLR;VPPHMLRAHIK;VTDTISR 7 5.6 0.97557 -3.4069 0 8.84015 2.38051 8.7003 9.09587 0 12.2031 0 0 9.43742 0 10.0233 Q6ZWJ1 STXB4_HUMAN Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) STXBP4 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335] syntaxin binding [GO:0019905] IMVLDCQLR;ISLNPSVR;QAHGMEMDYEEVIR 3 5.6 0.96426 -1.1143 0 0 0 7.47265 0 0 0 0 0 0 0 0 Q6ZWJ1 STXB4_HUMAN Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) STXBP4 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335] syntaxin binding [GO:0019905] IGVSFEEAK;ISLNPSVR 2 6.9 0.91871 -0.40336 0 0 0 0 10.1067 10.5411 0 0 0 0 0 0 Q6ZWJ8 KCP_HUMAN Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] APALSPGSCCPR;EHQDGEEFEGPAGSCEWCR;EVASGER;EVDPCRAAGYR;IPGQCCPVCDGCEYQGHQYQSQETFR;LQCPPLPCKLQVTER;QGPHDCCPQCSDCEHEGR;QGPHDCCPQCSDCEHEGRK 8 7 0.97305 -1.3755 11.626 0 0 10.4113 4.61088 8.76679 8.42034 0 5.70981 5.77252 9.25406 0 Q6ZWJ8 KCP_HUMAN Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] APALSPGSCCPR;ASCDGSR;GYPPGLELPPVLLQMEWSRR 3 13.3 0.91736 -0.42189 0 5.30834 0 8.75024 0 0 0 0 0 0 0 0 Q6ZWJ8 KCP_HUMAN Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] GDCCPDCDGEGHGIGSCR;IPGQCCPVCDGCEYQGHQYQSQETFR 2 5.4 0.7947 0.015795 0 0 5.44374 0 0 0 6.42722 0 0 0 0 0 Q6ZWK4 RHEX_HUMAN Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein) RHEX C1orf186 Homo sapiens (Human) cellular response to erythropoietin [GO:0036018]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of erythrocyte differentiation [GO:0045648] plasma membrane [GO:0005886] erythropoietin receptor binding [GO:0005128] MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSR 1 20.3 0.77743 0.03484 0 0 0 6.4206 6.31435 11.0133 0 0 0 0 0 0 Q6ZWK6 TM11F_HUMAN Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4) TMPRSS11F HATL4 Homo sapiens (Human) establishment of skin barrier [GO:0061436]; proteolysis [GO:0006508] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] DPTQWIATFGATITPPAVKR;HSSVGGR;VTKYRDWIASK;VTNIKYKENYGIR 4 11.6 0.97788 -2.1365 11.9222 0 8.53341 5.52262 0 9.62185 0 0 0 0 0 0 Q6ZWL3 CP4V2_HUMAN Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4V2 Homo sapiens (Human) fatty acid omega-oxidation [GO:0010430]; retinoid metabolic process [GO:0001523]; sterol metabolic process [GO:0016125]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" LSHEDIR 1 1.3 0.93756 -0.55994 0 0 0 0 0 0 0 0 9.51278 0 0 0 Q6ZXV5 TMTC3_HUMAN Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3) TMTC3 Homo sapiens (Human) positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked mannosylation [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] ALPILEELLR;ILEMDPSNVQGK;ISSVEGK;SALFNLALLYSQTAK 4 4.8 0.97622 -2.2666 0 8.99851 0 10.5407 0 0 0 0 0 0 0 0 Q701N2 KRA55_HUMAN Keratin-associated protein 5-5 (Keratin-associated protein 5-11) (Keratin-associated protein 5.11) (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) KRTAP5-5 KAP5-11 KAP5.5 KRTAP5-11 KRTAP5.11 KRTAP5.5 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] GCCGCSGGCGSGCGGR;MGCCGCSGGCGSGCGGR 2 7.2 0.50502 0.18802 0 5.32124 0 7.62928 0 0 0 0 0 0 0 0 Q701N4 KRA52_HUMAN Keratin-associated protein 5-2 (Keratin-associated protein 5-8) (Keratin-associated protein 5.2) (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.2) KRTAP5-2 KAP5-8 KAP5.2 KRTAP5-8 KRTAP5.2 KRTAP5.8 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] GCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGR;GCGSGCGGCGSSCGGCGSGCGGCGSGR;GGCGSGCGGCSSSCGGCGSR;MGCCGCSR 4 31.1 0.86491 -0.089634 0 3.7722 0 6.37834 0 0 0 4.414 0 4.67146 6.35413 4.08789 Q702N8 XIRP1_HUMAN Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) XIRP1 CMYA1 XIN Homo sapiens (Human) actin filament organization [GO:0007015]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of protein binding [GO:0032091]; protein localization [GO:0008104]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901] adherens junction [GO:0005912]; desmosome [GO:0030057] actin filament binding [GO:0051015]; RNA binding [GO:0003723] ASERSSVQLLASCIDK;EQQERQK;EVFQALEAGK;GHFQGPPK;HVFETEPLQASGRPCGRRPVR;IICQVLR;LTSKASERSSVQLLASCIDK 7 4 0.9751 -4.1802 0 0 0 9.93164 0 0 9.53481 12.0524 0 0 10.7409 0 Q709C8 VP13C_HUMAN Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) VPS13C KIAA1421 Homo sapiens (Human) Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; negative regulation of type 2 mitophagy [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; response to insulin [GO:0032868] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dense core granule membrane [GO:0032127]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741] DTATAER;EVVVTLMKKSEK;ISVKEQGLFHK;KYKPYLPLHTNGRR;LENIIVTDVDPKTVHK;NIPEILKIQIIGLGTQVSQRPGAQALKVEAK;VEGKRQWNLR;VGCIQIVYVHK;YTQMWSWSNIKK 9 3.3 0.97354 -2.5463 0 0 9.88597 9.98769 0 8.61526 8.55616 9.35782 0 3.84217 8.80093 7.45129 Q709F0 ACD11_HUMAN Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.8.-) ACAD11 Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099] EVTEFYVQNENSVDK;LDNIVFHPKECR;WWSSGAGNPKCK 3 5 0.97833 -1.976 0 0 0 10.3449 0 8.57679 0 0 12.0861 12.975 13.0678 0 Q70CQ1 UBP49_HUMAN Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) USP49 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2B deubiquitinase activity [GO:0140936]; zinc ion binding [GO:0008270] ILIPFSQR;LLARTLRLWFEK;LTKQVLK;SSRGQAK;TVQGNAR 5 6 0.98072 -1.6735 10.0471 0 0 0 3.20638 11.0951 0 0 0 11.7479 0 0 Q70CQ2 UBP34_HUMAN Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] DDEGATPIKR;DTLEGDNMYTCSHCGK;EILDHQDGNVEDDGLTGLLR;HCSRYIHDLFPSLIKNLDPVPLR;IFTYINSWTQR;IWEVIEYNPSQCLDWLAVQTPRNK;IWLHIPAVMQHIIPFR;LLTLLNSYSPPELRNACIDVLK;RMEPEEENGREYK;TYVIRYLCKLSDQELR;VLKAQSDHR;VSSDEEHTVDSCISDMK 12 5.6 0.80183 0.014337 0 0 0 0 0 0 0 0 0 0 8.36886 0 Q70CQ2 UBP34_HUMAN Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] DDEGATPIKR;DTLEGDNMYTCSHCGK;EILDHQDGNVEDDGLTGLLR;HCSRYIHDLFPSLIKNLDPVPLR;IWEVIEYNPSQCLDWLAVQTPRNK;IWLHIPAVMQHIIPFR;KNSYYVWQK;LLTLLNSYSPPELRNACIDVLK;NSYYVWQK;RMEPEEENGREYK;TYVIRYLCKLSDQELR;VLKAQSDHR;VSSDEEHTVDSCISDMK 13 5.9 0.97691 -4.7613 7.48623 0 7.90755 9.32414 0 0 11.3604 7.94445 8.44679 10.4074 9.24332 10.5015 Q70CQ3 UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) USP30 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; pexophagy [GO:0000425]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005] MQHQSQECKSEE 1 2.3 0.9257 -0.45256 3.09226 0 0 0 0 0 0 0 0 0 0 0 Q70CQ4 UBP31_HUMAN Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) USP31 KIAA1203 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] FSGDSPIHSSASTLEK;LVVEWDK;RMKLQNMVK;SPFPPGK 4 2.9 0.97209 -2.7162 10.1348 7.46263 0 0 0 0 0 0 9.70506 0 0 0 Q70E73 RAPH1_HUMAN Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) axon extension [GO:0048675]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] GKAKVSR;TLHQWVNGIR;VAVVNPQPQQWSK;YALFKNPQNYLLGK 4 3.5 0.91629 -0.43071 8.5998 0 0 0 0 0 0 0 0 0 10.9088 0 Q70EK8 UBP53_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin-specific peptidase 53) USP53 KIAA1350 Homo sapiens (Human) action potential [GO:0001508]; epithelial cell apoptotic process [GO:1904019]; outer hair cell apoptotic process [GO:1905584]; protein deubiquitination [GO:0016579]; response to auditory stimulus [GO:0010996]; sensory perception of sound [GO:0007605] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911] ATSHLPK;GDCTSLQSQHHLEGFR;GNSCDSSSK;GWKPMRETLNVDSIFSESEKR;SDNGTGYDTDSSQDSRDRGNSCDSSSK 5 6.6 0.97214 -2.8035 0 6.66903 0 0 0 9.27396 0 9.418 10.4435 0 9.58209 6.72955 Q70EK9 UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) USP51 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of cell cycle process [GO:0010564]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032] chromosome [GO:0005694]; nucleus [GO:0005634] chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; zinc ion binding [GO:0008270] CNSCQSYQESTK;KPRPRPQPRARSR 2 3.5 0.39381 0.21293 0 0 0 0 0 0 4.17121 0 0 0 7.58015 0 Q70EL1 UBP54_HUMAN Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) USP54 C10orf29 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] EDICTAQHCISHQK;LAEPDIYQEK;RSFRQLTTHK;SQPFSGEEISSKSELDELQEEVARR;TCYDSEDSGR;TVGEGFLFVLSDAPRR 6 5 0.87891 -0.14327 0 6.60272 10.756 0 0 2.03252 3.18191 10.7912 0 0 6.54574 0 Q70EL2 UBP45_HUMAN Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) USP45 Homo sapiens (Human) cell migration [GO:0016477]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; neural retina development [GO:0003407]; photoreceptor cell maintenance [GO:0045494]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] HASKTQTSAFSRIMK;KQLLISAVPAVLILHLK;LSEHNTKKK;NENLEMNGDSLMFASLMNSESR 4 7.7 0.94585 -0.65222 0 0 0 9.91395 8.95198 0 0 0 0 9.08066 0 2.88045 Q70EL4 UBP43_HUMAN Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) USP43 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; translesion synthesis [GO:0019985] nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785] AMNWKESFQMGSK;ASRAPRGSALGMSQR;FCQVGERR;FLRVGLAVPILSTVAALR;GAYILFYQK;LAVEWDSSVK;VGLAVPILSTVAALR 7 6.5 0.97479 -3.8427 5.04037 12.8162 12.8085 0 0 0 0 14.5678 4.50843 9.58423 0 12.9066 Q70HW3 SAMC_HUMAN Mitochondrial S-adenosylmethionine carrier protein (SAM carrier) (Solute carrier family 25 member 26) SLC25A26 SAMC Homo sapiens (Human) macromolecule methylation [GO:0043414]; mitochondrial S-adenosyl-L-methionine transmembrane transport [GO:1990543]; monoatomic ion transport [GO:0006811]; S-adenosyl-L-methionine transport [GO:0015805] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] S-adenosyl-L-methionine transmembrane transporter activity [GO:0000095]; S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity [GO:0180003] QDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAK;VPSEVVKQR 2 15 0.98041 -1.6087 0 15.2148 0 9.63621 0 0 0 0 0 0 0 0 Q70IA8 MOB3C_HUMAN MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C) MOB3C MOBKL2C Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] VGVPFPK 1 3.2 0.90973 -0.31132 0 0 0 8.44381 0 0 0 0 0 0 0 0 Q70J99 UN13D_HUMAN Protein unc-13 homolog D (Munc13-4) UNC13D Homo sapiens (Human) defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304]; secretion [GO:0046903] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; recycling endosome [GO:0055037]; Weibel-Palade body [GO:0033093] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] ELCQLRMSSSER;RIFKEAR 2 1.7 0.97472 -1.4293 0 0 0 0 0 0 0 0 0 7.40761 0 0 Q70JA7 CHSS3_HUMAN Chondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3) CHSY3 CHSY2 CSS3 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] KVHILVPLIGR;SSPWQQPPPLQQRR 2 2.8 0.08 0.40129 0 0 1.85671 0 0 0 0 0 0 5.96841 6.21341 0 Q70SY1 CR3L2_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] CREB3L2 BBF2H7 Homo sapiens (Human) cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]" GIFCESPMFKK;KVEVLENTNR 2 4.6 0.87829 -0.13671 0 0 0 0 0 0 0 0 5.84965 9.92607 0 0 Q70UQ0 IKIP_HUMAN Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein) IKBIP IKIP Homo sapiens (Human) response to X-ray [GO:0010165] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730] FLSLEGDR;IGRLVTDLLQR;NTVKNIGDLLSSSIDR;TLTELKSDFDKHTDR 4 14.3 0.95525 -0.79064 0 0 0 9.11556 0 0 0 13.7859 7.50613 11.7796 0 0 Q70UQ0 IKIP_HUMAN Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein) IKBIP IKIP Homo sapiens (Human) response to X-ray [GO:0010165] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730] VEEQLGSDTK 1 2.7 0.88754 -0.19886 0 0 0 0 0 0 0 0 0 9.20858 0 0 Q70YC5 ZN365_HUMAN Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48) ZNF365 DBZ KIAA0844 Homo sapiens (Human) cerebellar molecular layer morphogenesis [GO:0021687]; dendrite arborization [GO:0140059]; dendritic spine morphogenesis [GO:0060997]; negative regulation of neuron projection development [GO:0010977]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA strand resection involved in replication fork processing [GO:0110026]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of neuron projection development [GO:0010975]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; cytoplasm [GO:0005737] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] AHLEFSHSYEERTLLTK;DLCRPPK;DLCRPPKK;SGPGLPTSDTKASFEAHVR 4 10.8 0.95548 -0.80967 13.0744 0 9.0442 0 8.88545 0 1.98517 0 0 0 7.81308 0 Q70Z35 PREX2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)" PREX2 DEPDC2 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] ETHASVIAHVTACRK;LRLHIKQDPWNLPSSVR;LYKMMCR;TLAQNIRK;WFVCMAK 5 3.4 0.91125 -0.28559 0 0 0 7.75995 0 7.50032 0 0 13.3061 0 0 0 Q70Z44 5HT3D_HUMAN 5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D) HTR3D Homo sapiens (Human) inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ASMSIVK;SPSALSPTQVAIRRR 2 7.9 0.9158 -0.39115 0 0 0 8.39926 8.33307 8.41155 8.47362 0 0 0 0 0 Q70Z44 5HT3D_HUMAN 5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D) HTR3D Homo sapiens (Human) inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] TIKVTVATNQYEQAIFHVAIRR 1 5.4 0.55842 0.18276 0 0 0 3.51538 0 0 0 0 0 0 0 0 Q70Z53 F10C1_HUMAN Protein FRA10AC1 FRA10AC1 C10orf4 PRO2972 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634] phosphatase activity [GO:0016791] LAKKYYDK;LSSAEEASK;MHGHGGYDSDFSDDERCGESSK 3 12.4 0.97797 -2.0624 0 7.52254 0 0 0 0 0 0 0 11.8211 0 0 Q711Q0 CEFIP_HUMAN Cardiac-enriched FHL2-interacting protein CEFIP C10orf71 Homo sapiens (Human) positive regulation of calcineurin-NFAT signaling cascade [GO:0070886] Z disc [GO:0030018] DVSAGDSQKDEKENVMR 1 1.2 0.95624 -0.99506 0 0 0 0 0 0 0 0 0 0 0 11.69 Q712K3 UB2R2_HUMAN Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) UBE2R2 CDC34B UBC3B Homo sapiens (Human) protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] EYAEIIRK 1 3.4 0.84748 -0.062506 0 0 0 0 0 0 0 0 0 0 9.90415 0 Q717R9 CYS1_HUMAN Cystin-1 (Cilia-associated protein) CYS1 Homo sapiens (Human) ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] MGSGSSRSSR 1 6.3 0.88745 -0.18469 0 0 0 0 0 0 9.60844 0 0 0 0 0 Q719H9 KCTD1_HUMAN BTB/POZ domain-containing protein KCTD1 (Potassium channel tetramerization domain-containing protein 1) KCTD1 C18orf5 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260] nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] DGQMFRYILNFLRTSK 1 6.2 0.96426 -1.1138 0 0 0 0 9.68083 0 0 0 0 0 0 0 Q719I0 AHSA2_HUMAN Putative activator of 90 kDa heat shock protein ATPase homolog 2 (Activator of HSP90 ATPase homolog 2 pseudogene) AHSA2P AHSA2 Homo sapiens (Human) protein folding [GO:0006457] cytosol [GO:0005829] ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087] DATSLSK 1 2.3 0.90918 -0.31529 0 0 9.68194 0 0 0 0 0 0 0 8.54709 0 Q71F23 CENPU_HUMAN Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) CENPU ICEN24 KLIP1 MLF1IP PBIP1 Homo sapiens (Human) chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GKISHDK 1 1.7 0.89914 -0.25809 0 0 0 0 0 0 0 0 0 0 0 9.29717 Q71F78 LCA10_HUMAN Putative lung carcinoma-associated protein 10 LCA10 Homo sapiens (Human) SSCPVHDCPSWDPER 1 9.1 0.78131 0.021767 0 0 0 0 0 0 0 0 0 0 7.01814 0 Q71H61 ILDR2_HUMAN Immunoglobulin-like domain-containing receptor 2 (Angulin-3) ILDR2 C1orf32 Homo sapiens (Human) cell differentiation [GO:0030154]; homeostasis of number of cells within a tissue [GO:0048873]; insulin secretion [GO:0030073]; negative regulation of T cell activation [GO:0050868]; pancreas development [GO:0031016]; regulation of RNA splicing [GO:0043484]; response to glucose [GO:0009749] bicellular tight junction [GO:0005923]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; tight junction [GO:0070160] NFATGVPAVSMDELAAFADSYGQRPRR;RADGNSHEARGGSR 2 6.3 0.72188 0.13278 0 0 0 0 0 0 6.41657 0 0 0 0 7.35491 Q71RC2 LARP4_HUMAN La-related protein 4 (La ribonucleoprotein domain family member 4) LARP4 PP13296 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; positive regulation of translation [GO:0045727]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell morphogenesis [GO:0022604]; translation [GO:0006412] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723] EQYVPPRSPK;ETSTLQVEQNGDYGR;ISRPHPSTAESK;SSPMVQVDEKGEK;VRPSHKRCIVILR 5 8.7 0.97482 -3.6222 0 0 0 0 0 11.268 0 0 0 0 10.4192 2.80931 Q71SY5 MED25_HUMAN Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) MED25 ACID1 ARC92 PTOV2 TCBAP0758 Homo sapiens (Human) negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of mediator complex assembly [GO:2001178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; transcription coactivator binding [GO:0001223] SLPCQVYVNHGENLK;VFREKWER 2 2.9 0.96111 -1.0574 0 0 0 0 0 0 0 0 0 0 0 9.76427 Q71U36 TBA1A_HUMAN Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] TUBA1A TUBA3 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; cellular response to calcium ion [GO:0071277]; centrosome cycle [GO:0007098]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; cytoskeleton-dependent intracellular transport [GO:0030705]; dentate gyrus development [GO:0021542]; flagellated sperm motility [GO:0030317]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular protein transport [GO:0006886]; locomotory exploration behavior [GO:0035641]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; motor behavior [GO:0061744]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neuron projection arborization [GO:0140058]; organelle transport along microtubule [GO:0072384]; pyramidal neuron differentiation [GO:0021859]; regulation of synapse organization [GO:0050807]; response to L-glutamate [GO:1902065]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]; smoothened signaling pathway [GO:0007224]; startle response [GO:0001964]; synapse organization [GO:0050808]; visual learning [GO:0008542] axonemal microtubule [GO:0005879]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; sperm flagellum [GO:0036126] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] AVCMLSNTTAIAEAWAR;AVFVDLEPTVIDEVR;DVNAAIATIK;EDAANNYAR;EDMAALEK;EIIDLVLDR;FDGALNVDLTEFQTNLVPYPR;FDLMYAK;GHYTIGK;IHFPLATYAPVISAEK;LIGQIVSSITASLR;LSVDYGK;LSVDYGKK;NLDIERPTYTNLNR;TIGGGDDSFNTFFSETGAGK;TIQFVDWCPTGFK;VGINYQPPTVVPGGDLAK;YMACCLLYR 18 47.7 0.084639 0.38859 12.1261 0 0 0 12.4519 12.6286 0 0 0 0 9.45701 13.1909 Q71UI9 H2AV_HUMAN Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2) H2AZ2 H2AFV H2AV Homo sapiens (Human) chromatin organization [GO:0006325]; heterochromatin formation [GO:0031507] extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGGKAGK;AGLQFPVGR;ATIAGGGVIPHIHK;GDEELDSLIK;HLQLAIR;IHRHLKTR 6 43 0.78365 0.01972 0 0 0 0 0 0 0 8.73958 0 0 0 0 Q71UI9 H2AV_HUMAN Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2) H2AZ2 H2AFV H2AV Homo sapiens (Human) chromatin organization [GO:0006325]; heterochromatin formation [GO:0031507] extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGGKAGK;AGLQFPVGR;ATIAGGEK;GDEELDSLIK;HLQLAIR;IHRHLKTR 6 43 0 7.5881 0 0 12.2908 0 0 0 0 0 0 0 10.2331 0 Q75N03 HAKAI_HUMAN E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) CBLL1 HAKAI RNF188 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; mRNA processing [GO:0006397]; negative regulation of cell adhesion [GO:0007162]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] GPPPPPR;IPIKLISKQANK;TINRMPAK 3 5.5 0.9751 -1.4351 0 0 0 0 3.33299 0 0 0 0 0 0 0 Q75N90 FBN3_HUMAN Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide] FBN3 KIAA1776 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] CECEMGFDPTEDHR;DVDECADGQQDCHARGMECK;GLGFASR;NCMDVDECAR;TLCPGGEGFQPNR 5 2.3 0.9097 -0.31026 0 5.3717 0 4.20359 8.0735 0 8.29751 8.36558 0 9.6855 0 0 Q75QN2 INT8_HUMAN Integrator complex subunit 8 (Int8) (Protein kaonashi-1) INTS8 C8orf52 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EKFFRTK;ESTLGIMYR;FLQAMAK;IDFLLEVCSRSVNLEKASESLK;ILKLLALKVAAHLK;KLREPLVLTIILSLFVK;LLALKVAAHLKWDLDILEK;LLVDQMRK;TAKDLWEVVVQICSVSSQHK;VAAHLKWDLDILEK 10 11.3 0.97563 -5.1418 0 0 12.283 8.16762 0 5.55275 0 0 9.54591 0 10.5231 6.29792 Q75T13 PGAP1_HUMAN GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) (hPGAP1) PGAP1 UNQ3024/PRO9822 Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; attachment of GPI anchor to protein [GO:0016255]; embryonic pattern specification [GO:0009880]; forebrain regionalization [GO:0021871]; GPI anchor biosynthetic process [GO:0006506]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "hydrolase activity, acting on ester bonds [GO:0016788]; phosphatidylinositol deacylase activity [GO:0050185]" GQEFAPK;HSRRSEK;LSVLYHHFIR;QLQLTTVR 4 3.5 0.88643 -0.19278 0 0 0 0 0 0 13.8882 13.2315 13.9074 11.8339 10.0213 0 Q75V66 ANO5_HUMAN Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E) ANO5 GDD1 TMEM16E Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; plasma membrane repair [GO:0001778] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; vesicle [GO:0031982] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] EAIYPLALNWWR;NQQSKDSIFFRDGIR 2 3 0.90999 -0.31175 0 12.239 10.6727 0 0 5.65071 0 0 0 0 0 0 Q75WM6 H1FNT_HUMAN Testis-specific H1 histone (Haploid germ cell-specific nuclear protein 1) (Histone H1.7) (Histone H1t2) H1-7 H1FNT HANP1 Homo sapiens (Human) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; sperm DNA condensation [GO:0035092]; spermatid nucleus elongation [GO:0007290] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492] ARPRAKEPPCAR;EQALTGEAQSRWPR;GHSATQLPAEKTVGGPSRGCSSSVLR 3 20.4 0.97937 -1.5441 0 0 13.9967 0 0 0 0 4.94148 0 0 6.43811 0 Q765I0 UTS2B_HUMAN Urotensin-2B (Urotensin II-related peptide) (Urotensin IIB) (U-IIB) (UIIB) (Urotensin-2 domain-containing protein) UTS2B URP UTS2D Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; regulation of blood pressure [GO:0008217] extracellular region [GO:0005576] G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179] YTNREELLLALLNK 1 11.8 0.92153 -0.44561 9.27884 0 0 0 0 0 0 0 0 0 0 0 Q765P7 MTSS2_HUMAN Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) MTSS2 MTSS1L Homo sapiens (Human) activation of GTPase activity [GO:0090630]; cell projection assembly [GO:0030031]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009] actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; lamellipodium [GO:0030027]; ruffle membrane [GO:0032587] "actin binding [GO:0003779]; actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]" GLSLEHQK;LRQFTNALLESLINPLQER;NSNIAQNYRR 3 5 0.97149 -1.3523 0 0 10.411 0 0 0 12.7883 0 0 0 0 0 Q76B58 BRNP3_HUMAN BMP/retinoic acid-inducible neural-specific protein 3 (DBCCR1-like protein 1) BRINP3 DBCCR1L DBCCR1L1 FAM5C Homo sapiens (Human) cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] DPSIAHR;ENDCWCHCGPK;LNSWFDPSWR 3 4.2 0.93357 -0.50223 0 6.16974 0 0 0 0 5.90352 0 0 9.67223 0 0 Q76FK4 NOL8_HUMAN Nucleolar protein 8 (Nucleolar protein Nop132) NOL8 C9orf34 NOP132 Homo sapiens (Human) protein localization to nucleolus [GO:1902570]; rRNA processing [GO:0006364] chromosome [GO:0005694]; nucleolus [GO:0005730] RNA binding [GO:0003723] FFFFSKNDER;GSVAAKK;LFDSSDDDESDSEDDSNR;LHSLIGLGIK;LQGSDLFWR;THNIGFDK;TTNLRMDCR;VETVKPGKIVWQEDPR 8 7.5 0.97445 -3.8634 9.81455 0 3.72509 5.05624 9.55055 9.30524 10.2982 10.93 8.23309 9.58024 9.72352 7.99786 Q76G19 PDZD4_HUMAN PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) PDZD4 KIAA1444 PDZK4 PDZRN4L Homo sapiens (Human) cell cortex [GO:0005938] AMAGNSNLNR;GCNMCVVQKPEEQYK 2 3.3 0.91511 -0.37749 0 0 0 0 0 0 0 10.4556 9.6672 0 0 0 Q76KD6 SPERI_HUMAN Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein) SPATC1 SPATA15 SPRN Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737] FPENPRESK;YVSVMNRLQSLGYNGRVHPALTEQLVNAYGILR 2 7.1 0.9807 -1.62 3.414 0 0 0 0 0 0 0 0 0 8.40998 10.143 Q76KP1 B4GN4_HUMAN "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (NGalNAc-T1) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4)" B4GALNT4 Homo sapiens (Human) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842] LLLLLLLLSCAAWLTYVHLGLVRQGR;NFYHHYHSKRGMWSVR;QDDRGSDHVEVGWR 3 5.4 0.98057 -1.5971 0 0 0 0 0 0 0 9.15522 0 9.85351 0 0 Q76KX8 ZN534_HUMAN Zinc finger protein 534 (KRAB domain only protein 3) ZNF534 KRBO3 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NDFLFSTLLPQEQKVHIR;VFSRNSHLARHR 2 6.2 0.9112 -0.28675 0 0 0 0 10.2958 0 0 0 10.0143 0 0 0 Q76L83 ASXL2_HUMAN Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) ASXL2 ASXH2 KIAA1685 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] AASDSVPAKPATWEGK;KLTASPSDPK;TLQSKQLPQVPRPLQLFSAK 3 3.2 0.95221 -0.70739 0 0 0 0 0 7.40096 0 0 0 0 0 6.15749 Q76LX8 ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) ADAMTS13 C9orf8 UNQ6102/PRO20085 Homo sapiens (Human) blood coagulation [GO:0007596]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; extracellular matrix organization [GO:0030198]; glycoprotein metabolic process [GO:0009100]; integrin-mediated signaling pathway [GO:0007229]; peptide catabolic process [GO:0043171]; platelet activation [GO:0030168]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to amine [GO:0014075]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] AGLAWSPCSR;AVACTFAR;LLDMTFSSK;MHQRHPRAR;QLLSLLSAGRAR;RGDSFLDGTRCMPSGPR;VLESSLNCSAGDMLLLWGRLTWR;WHVGTWMECSVSCGDGIQRR 8 7.6 0.97344 -2.9051 7.70023 0 0 0 0 10.3318 0 10.6216 6.46922 0 8.42555 12.6271 Q76M96 CCD80_HUMAN Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog) CCDC80 DRO1 URB HBE245 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; response to bacterium [GO:0009617] basement membrane [GO:0005604]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] fibronectin binding [GO:0001968]; heparin binding [GO:0008201] EGIVCKEDKK;KEYGMTYNDFFMVLTDVDLR;MLRFPSGSSSPNILASFAGKNR;RLLLITAPK;VPLVSPDSSRPAR 5 7.8 0.96639 -1.2771 10.5008 0 0 0 0 4.9555 0 8.2612 0 0 10.6655 0 Q76MJ5 ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN2 IRE2 Homo sapiens (Human) apoptotic chromosome condensation [GO:0030263]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; rRNA catabolic process [GO:0016075] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum quality control compartment [GO:0044322]; IRE1-TRAF2-ASK1 complex [GO:1990604] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; endonuclease activity [GO:0004519]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082] APALRWNTTYR;LYIGRTQYTVTMHDPRAPALR;QAQPLDDPEAEQLTVVGK;QQQPQVVEK 4 5.8 0.95993 -1.0514 9.81773 0 0 0 0 10.2398 0 0 0 0 0 0 Q76N32 CEP68_HUMAN Centrosomal protein of 68 kDa (Cep68) CEP68 KIAA0582 Homo sapiens (Human) centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; protein localization to organelle [GO:0033365] cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] ESLVQCVK;KGGEQGK 2 2 0.89198 -0.21547 0 0 3.80312 0 0 7.864 0 0 9.47297 11.1614 0 0 Q76N89 HECW1_HUMAN "E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)" HECW1 KIAA0322 NEDL1 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] GVNGSHR;IDSHGRVFYVDHVNR;LSMPVQR;SGSIQQMEQLNR 4 2.6 0.97607 -2.3432 0 0 0 0 0 0 0 0 9.28526 0 0 0 Q76NI1 KNDC1_HUMAN Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9 Homo sapiens (Human) cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite development [GO:0050773]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase-mediated signal transduction [GO:0007264] dendrite [GO:0030425]; guanyl-nucleotide exchange factor complex [GO:0032045]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] guanyl-nucleotide exchange factor activity [GO:0005085] ALGVMDK;ALLSTPVR;GTDLENPR;LEDFISSK;LLSDSPEATLCLPLTR;LQVNLLSKFLLIAK 6 3.5 0.97993 -1.8725 15.2296 15.9647 0 12.5556 13.8259 13.9516 13.1111 0 14.4761 15.9111 15.7907 0 Q76NI1 KNDC1_HUMAN Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9 Homo sapiens (Human) cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite development [GO:0050773]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase-mediated signal transduction [GO:0007264] dendrite [GO:0030425]; guanyl-nucleotide exchange factor complex [GO:0032045]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] guanyl-nucleotide exchange factor activity [GO:0005085] ALLSTPVR;GGLRPGSPGCR;LLSDSPEATLCLPLTR;VPRAPNRVTLVLVPPPR 4 3.7 0.91665 -0.35054 0 8.33989 0 9.10261 0 0 0 11.5775 0 0 0 0 Q7KYR7 BT2A1_HUMAN Butyrophilin subfamily 2 member A1 BTN2A1 BT2.1 BTF1 Homo sapiens (Human) lipid metabolic process [GO:0006629]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] ELEKERVQK;VGTHQSL 2 3 0.97611 -1.4503 0 0 0 9.57111 0 0 0 0 0 0 0 0 Q7KZ85 SPT6H_HUMAN Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) SUPT6H KIAA0162 SPT6H Homo sapiens (Human) blastocyst formation [GO:0001825]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; RNA splicing [GO:0008380]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] FLSDKVVKRPEER;GAEDDELEEEADWIYR;GTHLLKILK;IMKIDIEK;MSDDEDDDEEEYGK;TAWREEEREK;VNEVGVDVNR;YLKNKPVKELR 8 5.3 0.97525 -2.357 6.89239 6.66263 12.1502 8.96012 6.45533 0 0 8.21096 12.0168 0 0 0 Q7KZF4 SND1_HUMAN Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) SND1 TDRD11 Homo sapiens (Human) miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; osteoblast differentiation [GO:0001649]; regulation of cell cycle process [GO:0010564]; regulatory ncRNA-mediated gene silencing [GO:0031047] cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; RNAi effector complex [GO:0031332] "cadherin binding [GO:0045296]; endonuclease activity [GO:0004519]; endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [GO:0016894]; nuclease activity [GO:0004518]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; transcription coregulator activity [GO:0003712]" ADDADEFGYSR;ASSAQSGGSSGGPAVPTVQR;DTPDEPWAFPAR;EADGSETPEPFAAEAK;GGPPPER;IHVFYIDYGNREVLPSTRLGTLSPAFSTR;LEGENTQDK;LGTLSPAFSTR;LSECEEQAK;QINLSNIR;SLLSAEEAAK;TDAVDSVVR;VADISGDTQK 13 16.5 0 8.1702 0 0 0 0 0 9.04745 10.4527 0 11.7637 13.0191 12.3543 11.2015 Q7KZI7 MARK2_HUMAN Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) MARK2 EMK1 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; establishment of cell polarity [GO:0030010]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion localization [GO:0051646]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule binding [GO:1904526]; regulation of microtubule cytoskeleton organization [GO:0070507]; Wnt signaling pathway [GO:0016055] actin filament [GO:0005884]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule bundle [GO:0097427]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] ESGRKASSTAK;RPHVVGSGGNDKEKEEFR 2 4.2 0.95515 -0.82034 6.12383 6.46566 0 0 0 0 0 10.6178 0 0 0 4.02192 Q7KZN9 COX15_HUMAN Heme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15 homolog) COX15 Homo sapiens (Human) cytochrome complex assembly [GO:0017004]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783] cytochrome complex [GO:0070069]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex [GO:0098803] "heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]" ISDLDEGIR;LPETHQLLQLR 2 5.2 0.95728 -1.0216 0 0 0 0 0 0 0 0 0 0 0 11.2617 Q7L014 DDX46_HUMAN Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) DDX46 KIAA0801 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EIEEMKQGKK;IEYEPFR;SSGFSGK 3 2.3 0.98065 -1.6754 0 0 0 8.95664 0 9.04385 10.3503 0 0 0 0 10.0627 Q7L099 RUFY3_HUMAN Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) RUFY3 KIAA0871 Homo sapiens (Human) actin filament organization [GO:0007015]; cell differentiation [GO:0030154]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; regulation of axonogenesis [GO:0050770]; regulation of establishment of cell polarity [GO:2000114] anchoring junction [GO:0070161]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] DLVKQAKTLNSAANK;LTEELAVANNR;QAKTLNSAANKLIPK 3 6.4 0.87492 -0.12192 0 0 0 0 0 10.3901 11.463 0 10.0464 0 0 0 Q7L0J3 SV2A_HUMAN Synaptic vesicle glycoprotein 2A SV2A KIAA0736 PSEC0174 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; regulation of gamma-aminobutyric acid secretion [GO:0014052]; synaptic vesicle priming [GO:0016082] cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] protein kinase binding [GO:0019901]; transmembrane transporter activity [GO:0022857] FEEEDDDDDFPAPSDGYYR;GGLSDGEGPPGGRGEAQRR;QVHDTNMR 3 6.2 0.92912 -0.48406 4.1784 0 0 0 0 0 0 0 0 0 0 8.46785 Q7L0L9 YA043_HUMAN Transmembrane protein LOC653160 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VAKAFQPSQGCSR 1 6 0.92149 -0.44583 0 0 0 0 9.80991 0 0 0 0 0 0 0 Q7L0X0 TRIL_HUMAN TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644) TRIL KIAA0644 Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696] lipopolysaccharide binding [GO:0001530] FLAGVAWDGAAR 1 1.5 0.93304 -0.49626 0 0 0 9.21084 0 0 0 0 0 0 0 0 Q7L0X2 ERIP6_HUMAN Glutamate-rich protein 6 (Protein FAM194A) ERICH6 C3orf44 FAM194A Homo sapiens (Human) IACGKVVRNELLEK;SPSGFGDPGKKDQK;TIRNIINEEI;VVRNELLEKHYK 4 6.2 0.97471 -1.4282 0 0 0 8.93926 0 8.30332 0 0 0 8.64699 9.15866 10.5788 Q7L0Y3 TM10C_HUMAN tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) TRMT10C MRPP1 RG9MTD1 Homo sapiens (Human) mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA processing [GO:0006397]; positive regulation of mitochondrial translation [GO:0070131] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tRNA (adenine(9)-N1)-methyltransferase activity [GO:0160106]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049] RKHTGFLEISQHSQEFINR 1 4.7 0.51107 0.18766 5.05255 0 0 0 0 0 0 0 0 0 0 0 Q7L190 DPPA4_HUMAN Developmental pluripotency-associated protein 4 DPPA4 Homo sapiens (Human) lung-associated mesenchyme development [GO:0060484]; system development [GO:0048731] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] LPPVNLIHRDILR;RLCAFAYPNQK 2 7.9 0.97575 -1.4541 0 11.0494 0 6.43941 0 0 0 0 0 0 0 0 Q7L1I2 SV2B_HUMAN Synaptic vesicle glycoprotein 2B SV2B KIAA0735 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] QVHDTNMR;QVWDNALYCVMGPYR 2 3.4 0.78335 0.022767 0 0 0 0 0 0 0 0 0 0 3.53269 0 Q7L1Q6 5MP2_HUMAN eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) BZW1 5MP2 BZAP45 KIAA0005 Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; membrane [GO:0016020] cadherin binding [GO:0045296]; RNA binding [GO:0003723] DIILYVKEEMKK;ELQEQMSR;NAEEESESEAEEGD;NNIHFMK;NQQTIGAR 5 13.9 0.973 -2.6547 8.45914 0 0 0 6.05899 0 0 8.51096 0 0 10.9001 0 Q7L1Q6 5MP2_HUMAN eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) BZW1 5MP2 BZAP45 KIAA0005 Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; membrane [GO:0016020] cadherin binding [GO:0045296]; RNA binding [GO:0003723] DIILYVKEEMKK;ELQEQMSR;NAEEESESEAEEGD;NQQTIGAR;YGAPGAPAQSASVTVVR 5 13.1 0.87015 -0.097733 0 0 0 0 0 0 0 0 0 0 0 12.663 Q7L1S5 CHST9_HUMAN Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2) CHST9 UNQ2549/PRO6175 Homo sapiens (Human) carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan metabolic process [GO:0030203]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020] chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146] FHMPEDVR;GIYTRLNTYTKAVFVR;LDSFDLKGIYTR;SLVKDNKWK 4 9 0.975 -2.3603 0 5.85162 0 7.30615 0 0 0 0 0 0 0 0 Q7L1T6 NB5R4_HUMAN Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) CYB5R4 NCB5OR Homo sapiens (Human) bicarbonate transport [GO:0015701]; cell development [GO:0048468]; detection of oxygen [GO:0003032]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; reactive oxygen species metabolic process [GO:0072593]; response to antibiotic [GO:0046677]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]" DINLDSIIVDHQNDSFR;VASGGRSK;VLNGMLPK;VVESVGK 4 7.7 0.9804 -1.5724 0 0 0 0 0 7.4933 10.669 9.48368 10.7401 0 0 0 Q7L1V2 MON1B_HUMAN Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein) MON1B HSRG1 KIAA0872 SAND2 Homo sapiens (Human) early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; Mon1-Ccz1 complex [GO:0035658] EGGGVHAVPPDPEDEGLEETGSKDK;LLAGSER;LSDLYHRLHAR 3 7.9 0.97588 -1.4848 12.8996 0 13.1027 0 0 11.2345 0 9.08937 0 0 0 0 Q7L1W4 LRC8D_HUMAN Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) LRRC8D LRRC5 UNQ213/PRO239 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; intracellular glucose homeostasis [GO:0001678]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; taurine transmembrane transport [GO:0015734] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] AHTPPGNAEVTTNIPK;FGVFLSEVSENK;VGQLSQLTQLELKGNCLDR 3 5.5 0.91553 -0.39158 0 0 0 7.53714 0 0 5.10819 0 0 7.93281 0 5.10823 Q7L211 ABHDD_HUMAN Protein ABHD13 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 13) (Abhydrolase domain-containing protein 13) ABHD13 C13orf6 Homo sapiens (Human) lipid metabolic process [GO:0006629] dendrite cytoplasm [GO:0032839]; membrane [GO:0016020] palmitoyl-(protein) hydrolase activity [GO:0008474] FQDVLLYFPEQPSSSR;YLPLWCYKNK 2 7.7 0.88124 -0.15115 0 0 9.37986 0 0 0 0 12.1629 0 0 12.5634 0 Q7L266 ASGL1_HUMAN Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] ASRGL1 ALP CRASH Homo sapiens (Human) asparagine catabolic process via L-aspartate [GO:0033345]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798] GVPEIPGEK;LVTERNKK 2 9.4 0.98151 -1.7718 0 11.6465 0 0 0 0 0 12.5946 12.5957 0 0 0 Q7L2E3 DHX30_HUMAN ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) DHX30 DDX30 KIAA0890 Homo sapiens (Human) central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DKLVYVHTNGPK;KIDAERQAAAAACQLFK;LEGDSRTVRLLK 3 3.4 0.96488 -1.1676 8.9922 0 0 0 0 0 0 11.7069 11.1765 6.86962 0 0 Q7L2H7 EIF3M_HUMAN Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) EIF3M HFLB5 PCID1 GA17 PNAS-125 Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]" translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] EGERPSLR;LLYEALVDCK;SVPAFIDISEEDQAAELR 3 9.6 0.012526 0.91143 0 0 8.25941 0 0 8.30241 0 0 0 0 0 0 Q7L2J0 MEPCE_HUMAN 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) MEPCE BCDIN3 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031] 7SK snRNP [GO:0120259]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] 7SK snRNA binding [GO:0097322]; O-methyltransferase activity [GO:0008171]; RNA 5'-gamma-phosphate methyltransferase activity [GO:1990276]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; snRNA binding [GO:0017069] GGGQGSK;LIHSARQNIRHYLSEELR;NGYQPHRPPGGGGGK;SSPLPAK 4 6.8 0.8886 -0.20153 11.0052 0 0 0 6.73998 0 0 0 0 0 0 10.1742 Q7L2K0 TEDC2_HUMAN Tubulin epsilon and delta complex protein 2 TEDC2 C16orf59 Homo sapiens (Human) positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737] ELEFLTQALEK 1 2.5 0.8976 -0.23247 0 12.6855 0 0 0 0 0 0 0 0 0 0 Q7L2R6 ZN765_HUMAN Zinc finger protein 765 ZNF765 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AYNCSSLLR;CEDCDEAFSFK;CEECDKAYSFK;CNECGKTFSQK;EVFHAGTSQR;KHQLIHLGEKQYK;RIYTGEK;TLYRDVMLENYR 8 16.1 0.97564 -3.4199 0 0 0 5.19034 0 5.80232 10.6537 12.6047 4.14045 10.0799 0 7.84216 Q7L2R6 ZN765_HUMAN Zinc finger protein 765 ZNF765 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ARQYRSDPHR;TLYRDVMLENYR 2 17.3 0.97495 -1.4357 0 0 0 0 0 0 9.5144 0 0 0 0 0 Q7L3S4 ZN771_HUMAN Zinc finger protein 771 (Mesenchymal stem cell protein DSC43) ZNF771 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]" LSSHFIR;LYICAGCGRDFK 2 6 0.94112 -0.61028 0 0 0 0 9.0404 0 0 0 9.16912 0 0 0 Q7L4I2 RSRC2_HUMAN Arginine/serine-rich coiled-coil protein 2 RSRC2 Homo sapiens (Human) RNA binding [GO:0003723] LQEQREKEMVEK 1 2.8 0.86665 -0.092777 0 0 0 0 0 0 0 0 0 0 10.7243 0 Q7L4P6 BEND5_HUMAN BEN domain-containing protein 5 BEND5 C1orf165 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] Golgi apparatus [GO:0005794] DNA binding [GO:0003677] HLQQELERTRR;LSKVNKYICEK;NYQQQQEEMR 3 7.6 0.96346 -1.0965 0 0 9.7626 0 6.77228 0 0 0 11.3293 0 0 0 Q7L576 CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) CYFIP1 KIAA0068 Homo sapiens (Human) "axon extension [GO:0048675]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cellular response to insulin stimulus [GO:0032869]; cognition [GO:0050890]; dendrite extension [GO:0097484]; lamellipodium assembly [GO:0030032]; modification of synaptic structure [GO:0099563]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite development [GO:1900006]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of myelination [GO:0031641]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to electrical stimulus [GO:0051602]; ruffle organization [GO:0031529]" axonal growth cone [GO:0044295]; central region of growth cone [GO:0090724]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; peripheral region of growth cone [GO:0090725]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; terminal bouton [GO:0043195]; tertiary granule lumen [GO:1904724] actin filament binding [GO:0051015]; RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267]; translation repressor activity [GO:0030371] FQILNDEIITILDKYLK;IRKFQILNDEIITILDK;TLMEVMPK;TVLPFSQEFQR;YSNKDCPDSAEEYERATR 5 4.5 0.95957 -1.0455 0 6.81865 0 0 6.53001 0 3.52143 0 0 0 0 0 Q7L576 CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) CYFIP1 KIAA0068 Homo sapiens (Human) "axon extension [GO:0048675]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cellular response to insulin stimulus [GO:0032869]; cognition [GO:0050890]; dendrite extension [GO:0097484]; lamellipodium assembly [GO:0030032]; modification of synaptic structure [GO:0099563]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite development [GO:1900006]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of myelination [GO:0031641]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to electrical stimulus [GO:0051602]; ruffle organization [GO:0031529]" axonal growth cone [GO:0044295]; central region of growth cone [GO:0090724]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; peripheral region of growth cone [GO:0090725]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; terminal bouton [GO:0043195]; tertiary granule lumen [GO:1904724] actin filament binding [GO:0051015]; RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267]; translation repressor activity [GO:0030371] AAATWPR;FQILNDEIITILDKYLK;IRKFQILNDEIITILDK;TLMEVMPK;TVLPFSQEFQR 5 5.6 0.70543 0.15988 0 0 0 0 0 0 0 0 0 5.35537 0 0 Q7L590 MCM10_HUMAN Protein MCM10 homolog (HsMCM10) MCM10 PRO2249 Homo sapiens (Human) cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA replication initiation [GO:0006270] nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA replication origin binding [GO:0003688]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] ASPPDPK;DCEYCQYHVQAQYK;DPQDILEVKER 3 3.7 0.98058 -1.7119 0 12.0076 0 9.43584 9.64393 0 8.00253 7.75936 0 0 0 9.01873 Q7L591 DOK3_HUMAN Docking protein 3 (Downstream of tyrosine kinase 3) DOK3 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] RKGPAPCDRP 1 2 0.97581 -1.4851 0 0 0 0 0 0 9.64607 0 0 0 0 0 Q7L592 NDUF7_HUMAN "Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog)" NDUFAF7 C2orf56 PRO1853 Homo sapiens (Human) "mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]" extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] enzyme binding [GO:0019899]; histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; methyltransferase activity [GO:0008168]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243] SGIPISWYRDLHDVPK 1 3.6 0.81225 -0.013834 0 0 0 0 0 0 0 0 0 8.74826 0 0 Q7L5A8 FA2H_HUMAN Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) (Fatty acid hydroxylase domain-containing protein 1) FA2H FAAH FAXDC1 Homo sapiens (Human) central nervous system myelin maintenance [GO:0032286]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; galactosylceramide biosynthetic process [GO:0006682]; glucosylceramide biosynthetic process [GO:0006679]; lipid modification [GO:0030258]; peripheral nervous system myelin maintenance [GO:0032287]; plasma membrane raft organization [GO:0044857]; regulation of acinar cell proliferation [GO:1904697]; regulation of hair cycle [GO:0042634]; regulation of sebum secreting cell proliferation [GO:1904002]; sebaceous gland cell differentiation [GO:0001949]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity [GO:0120521]; fatty acid 2-hydroxylase activity [GO:0080132]; free fatty acid 2-hydroxylase activity [GO:0120520]; heme binding [GO:0020037]; iron ion binding [GO:0005506] HSANARR;LAAGACWVRR;VVDWDKDLVDWRKPLLWQVGHLGEK 3 11.3 0.85614 -0.080962 0 7.48679 13.5164 0 0 5.37507 0 0 0 0 9.50803 6.86146 Q7L5L3 GDPD3_HUMAN Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) GDPD3 GDE7 Homo sapiens (Human) glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]; phosphatidylcholine catabolic process [GO:0034638] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] SSVMKKCK;TYFPFSCSCLNQLLAVVSKWLIMRK 2 10.4 0.96301 -1.1022 0 0 0 0 5.84381 7.75462 0 0 0 0 0 0 Q7L5N7 PCAT2_HUMAN Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) LPCAT2 AGPAT11 AYTL1 Homo sapiens (Human) membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0047159] RVQIVLLGIILLPIR;VDPDSRK;YLKLPVSDVLRQLFALFDR 3 7.5 0.8074 0.0070383 14.9269 0 0 9.8066 0 4.18174 0 3.82731 0 0 0 0 Q7L5Y1 ENOF1_HUMAN Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase) ENOSF1 RTS TYMSAS Homo sapiens (Human) amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052] mitochondrion [GO:0005739] hydro-lyase activity [GO:0016836]; isomerase activity [GO:0016853]; L-fuconate dehydratase activity [GO:0050023]; magnesium ion binding [GO:0000287] ALVPLGIGIATGEQCHNRVIFK;ASYMPPK;DLKDIVGDFRGFYR;QLCAQALK 4 11.5 0.95961 -1.0435 0 0 12.7268 0 0 0 0 0 0 0 0 0 Q7L5Y1 ENOF1_HUMAN Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase) ENOSF1 RTS TYMSAS Homo sapiens (Human) amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052] mitochondrion [GO:0005739] hydro-lyase activity [GO:0016836]; isomerase activity [GO:0016853]; L-fuconate dehydratase activity [GO:0050023]; magnesium ion binding [GO:0000287] ALVPLGIGIATGEQCHNRVIFK;ASYMPPK;GVELPSLWEK;MQKMESR;QLCAQALK 5 15 0.97332 -2.6496 0 0 0 0 0 0 0 0 11.0612 9.96307 10.159 0 Q7L5Y1 ENOF1_HUMAN Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase) ENOSF1 RTS TYMSAS Homo sapiens (Human) amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052] mitochondrion [GO:0005739] hydro-lyase activity [GO:0016836]; isomerase activity [GO:0016853]; L-fuconate dehydratase activity [GO:0050023]; magnesium ion binding [GO:0000287] ALVPLGIGIATGEQCHNRVIFK;ASYMPPK;RRCQIIR 3 16.9 0.97811 -1.5119 0 9.96359 0 0 0 0 0 0 0 0 0 0 Q7L5Y6 DET1_HUMAN DET1 homolog (De-etiolated-1 homolog) DET1 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; nucleus [GO:0005634] protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] RAEQDGSAMAK;TFKCDKVVLSHNQGLYLYK 2 5.5 0.22781 0.29959 0 0 0 0 9.60541 0 0 0 5.57404 0 6.59262 0 Q7L5Y9 MAEA_HUMAN E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) MAEA EMP HLC10 PIG5 Homo sapiens (Human) cell adhesion [GO:0007155]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; enucleate erythrocyte development [GO:0048822]; erythrocyte maturation [GO:0043249]; negative regulation of myeloid cell apoptotic process [GO:0033033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of mitotic cell cycle [GO:0007346] actomyosin contractile ring [GO:0005826]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; GID complex [GO:0034657]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AAQKNIDRETSHVTMVVAELEK;DLLDPARWR;QDDKVVCPRTK 3 10.6 0.9753 -4.2158 0 0 10.0877 0 0 0 0 12.813 0 0 14.9066 0 Q7L622 G2E3_HUMAN G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2E3 KIAA1333 Homo sapiens (Human) apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] CTICNNSDIFQKEMLR;ILSELFTVHTLPDVK;INTATTVADLK;KHDDCPNK;NGASIGCVAPR;QGLKTLGVLEK 6 10.2 0.97431 -3.5099 8.26669 6.3935 0 0 0 0 0 0 0 9.38243 11.6997 9.1895 Q7L775 EPMIP_HUMAN EPM2A-interacting protein 1 (Laforin-interacting protein) EPM2AIP1 KIAA0766 My007 Homo sapiens (Human) glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; response to insulin [GO:0032868] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nucleus [GO:0005634] identical protein binding [GO:0042802] GVACKVASLFDSNQICEK;GWGEGDFVYQCMEVLLR;ILSIDRNLR;NLRNQLFNRAR;NQLFNRARDFK 5 9.1 0.97974 -1.8787 10.8898 11.8056 0 0 0 0 0 0 0 9.35023 0 0 Q7L7V1 DHX32_HUMAN Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) DHX32 DDX32 Homo sapiens (Human) mitochondrion [GO:0005739]; spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GDIVVFLACEQDIEK 1 2 0.87958 -0.15483 0 0 0 0 0 0 0 0 0 0 9.07965 0 Q7L7X3 TAOK1_HUMAN Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) TAOK1 KIAA1361 MAP3K16 MARKK Homo sapiens (Human) central nervous system neuron development [GO:0021954]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of microtubule depolymerization [GO:0007026]; neuron cellular homeostasis [GO:0070050]; phosphorylation [GO:0016310]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein acetylation [GO:1901985]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule cytoskeleton organization [GO:0070507] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; alpha-tubulin binding [GO:0043014]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transferase activity [GO:0016740] AGSLKDPEIAELFFK;ELDNLQYRK;NREHFATIR;QRQYLELECR 4 4.3 0.97437 -2.4494 6.82591 10.1819 7.48422 0 0 0 0 0 0 0 0 0 Q7L804 RFIP2_HUMAN Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) RAB11FIP2 KIAA0941 Homo sapiens (Human) establishment of cell polarity [GO:0030010]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; phagocytosis [GO:0006909]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulated exocytosis [GO:0045055]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669] cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] DSRRSDK;KIPDSNPFDATAGYR 2 4.3 0.65563 0.16949 0 0 0 0 8.38754 0 0 0 0 0 0 9.25241 Q7L8A9 VASH1_HUMAN Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1) VASH1 KIAA1036 VASH Homo sapiens (Human) angiogenesis [GO:0001525]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of lymphangiogenesis [GO:1901491]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; response to wounding [GO:0009611] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423] DEEPEEEGEEDLR;DVSSPQRAQSSPHRR;GTGPPSPTK;KDVSSPQRAQSSPHR 4 10.4 0.83747 -0.032395 0 0 7.7303 0 0 0 0 0 9.41196 10.4955 8.98031 0 Q7L8J4 3BP5L_HUMAN SH3 domain-binding protein 5-like (SH3BP-5-like) SH3BP5L KIAA1720 UNQ2766/PRO7133 Homo sapiens (Human) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860] AQFSQILEEHK;GSDGGAR;LCQQAEARVQALQKTLR 3 8.9 0.73552 0.11143 0 0 8.75929 7.23649 0 0 9.66823 0 0 9.75427 0 0 Q7L8L6 FAKD5_HUMAN "FAST kinase domain-containing protein 5, mitochondrial" FASTKD5 KIAA1792 Homo sapiens (Human) mitochondrial RNA processing [GO:0000963]; mRNA processing [GO:0006397]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723]; rRNA binding [GO:0019843] LAVQFTNRNQYCYGSR;MFRFTHVDHINFMK;NICSTFSSRR;QIGEIAPQR 4 6.4 0.98009 -1.8373 0 0 6.51012 0 0 10.8582 0 0 0 0 0 10.9132 Q7L945 ZN627_HUMAN Zinc finger protein 627 ZNF627 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GGVPYKCKVCGK;VCGKAFDFPSSFRIHER 2 6.3 0.97864 -1.9208 0 0 0 0 0 11.1886 0 0 0 0 0 0 Q7L985 LIGO2_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 3) (Leucine-rich repeat neuronal protein 6C) LINGO2 LERN3 LRRN6C UNQ9234/PRO31993 Homo sapiens (Human) positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synaptic membrane [GO:0097060] IVILLDYMFQDLHNLK;LDISENK;SFKDFHSTALSFYFTCKKPK;SLEVGDNDLVYISHR 4 9.6 0.09771 0.37084 0 0 0 0 0 8.09117 0 0 0 0 0 7.30497 Q7L9B9 EEPD1_HUMAN Endonuclease/exonuclease/phosphatase family domain-containing protein 1 EEPD1 KIAA1706 Homo sapiens (Human) DNA repair [GO:0006281]; positive regulation of cholesterol efflux [GO:0010875] plasma membrane [GO:0005886] catalytic activity [GO:0003824]; DNA binding [GO:0003677] EYIGGFK;LATWNLQGCSVEK 2 3.5 0.90735 -0.30699 0 0 0 0 0 0 8.27636 4.56901 0 0 0 0 Q7L9L4 MOB1B_HUMAN MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) MOB1B MOB4A MOBKL1A Homo sapiens (Human) hippo signaling [GO:0035329]; regulation of protein autophosphorylation [GO:0031952] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] kinase activator activity [GO:0019209]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] MSFLFGSRSSKTFKPK;TILKRLFR 2 11.1 0.74572 0.096392 3.09292 0 0 0 5.17089 0 0 0 0 0 5.2834 0 Q7LBC6 KDM3B_HUMAN Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] antioxidant activity [GO:0016209]; chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AGSSVDRK;ECRLERYR;EQEQDDSTVACRFFHFRR;TIDEGDADEVTKQR 4 2.7 0.97343 -2.4915 0 0 0 0 0 0 9.61989 0 0 0 0 9.45306 Q7LBE3 S26A9_HUMAN Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) SLC26A9 Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; positive regulation of gene expression [GO:0010628]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] KYHMQIVGEIQR;YHMQIVGEIQR 2 1.5 0.91759 -0.36007 0 8.23266 0 0 0 0 0 0 0 0 9.60309 0 Q7LBR1 CHM1B_HUMAN Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2) CHMP1B C18orf2 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904] SMAGVVK;VDAVAAR 2 7 0.91677 -0.41074 0 0 0 0 0 0 0 0 0 9.08092 8.95201 0 Q7LFX5 CHSTF_HUMAN Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) CHST15 BRAG GALNAC4S6ST KIAA0598 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319] Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659] FSIGTER 1 1.4 0.93041 -0.46897 0 0 0 0 0 0 0 0 8.85387 0 0 0 Q7LG56 RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) RRM2B P53R2 Homo sapiens (Human) 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]; ribonucleoside diphosphate metabolic process [GO:0009185] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoside-diphosphate reductase complex [GO:0005971] "identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" QYIEFVADRLLVELGFSK 1 5.1 0.8129 -0.015497 0 0 0 0 0 6.17289 0 0 0 0 0 0 Q7LGA3 HS2ST_HUMAN Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-) HS2ST1 HS2ST KIAA0448 Homo sapiens (Human) "gene expression [GO:0010467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin metabolic process [GO:0030202]; ureteric bud formation [GO:0060676]" Golgi membrane [GO:0000139]; membrane [GO:0016020] heparan sulfate 2-O-sulfotransferase activity [GO:0004394] FGVKKKPIYINVIR;HTMDGPR;LVSYYYFLR 3 8.4 0.95544 -0.85827 7.04319 0 0 8.6749 0 9.41821 0 0 0 0 0 0 Q7LGC8 CHST3_HUMAN Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (C6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) CHST3 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]; T cell homeostasis [GO:0043029] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; proteoglycan sulfotransferase activity [GO:0050698] LAQVVQAACGPAMR 1 2.9 0.78186 0.021875 0 0 0 0 0 0 0 0 0 0 0 9.96694 Q7M4L6 SHF_HUMAN SH2 domain-containing adapter protein F SHF Homo sapiens (Human) apoptotic process [GO:0006915] phosphotyrosine residue binding [GO:0001784] QGSPGHR;VPENDGYMEPYEAQK 2 5.2 0.48477 0.19006 0 7.59388 0 0 8.09334 0 0 0 0 0 0 0 Q7RTM1 OTOP1_HUMAN Proton channel OTOP1 (Otopetrin-1) (hOtop1) OTOP1 Homo sapiens (Human) biomineral tissue development [GO:0031214]; cellular response to insulin stimulus [GO:0032869]; detection of gravity [GO:0009590]; inner ear morphogenesis [GO:0042472]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; proton transmembrane transport [GO:1902600] membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; proton channel activity [GO:0015252] MLEGLGSPASPR 1 2 0.80739 0.012083 0 0 0 0 0 0 0 8.4424 8.66039 0 0 0 Q7RTN6 STRAA_HUMAN STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) STRADA LYK5 STRAD Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] NPDARPSASTLLNHSFFK 1 4.2 0.78292 0.022541 0 0 0 0 0 0 0 0 0 9.9195 0 0 Q7RTN6 STRAA_HUMAN STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) STRADA LYK5 STRAD Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] YPCWPGPGLRESR 1 3.7 0.83277 -0.02841 0 0 0 0 2.37945 0 0 0 0 0 0 0 Q7RTP6 MICA3_HUMAN [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 KIAA0819 KIAA1364 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytosol [GO:0005829]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] "actin binding [GO:0003779]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" ALRGEAGMGKK;DLDGAGK;ELGISPIMTGK;GPEPSFPTPAFRPVSLK;LLGWCQR;LSAEGKFFHR;RVQKAAR;TEEELSEEK 8 3.9 0.97648 -4.9642 0 11.0105 0 7.47994 2.61791 10.406 0 0 10.6253 0 8.40472 11.5737 Q7RTP6 MICA3_HUMAN [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 KIAA0819 KIAA1364 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytosol [GO:0005829]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] "actin binding [GO:0003779]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" DLDADNRGK;DLDGAGK;ELGISPIMTGK;LLGWCQR;LSAEGKFFHR;QSPHHERPEPEPPRR 6 5.5 0.96673 -1.2881 0 0 0 0 8.16982 0 0 0 9.93038 0 0 10.584 Q7RTR0 NLRP9_HUMAN "NACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12)" NLRP9 NALP9 NOD6 PAN12 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interleukin-18 production [GO:0032741]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727] canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737] ATP binding [GO:0005524] ALKVFNFVR 1 0.9 0.97968 -1.5653 11.6631 0 0 0 0 0 0 0 0 0 0 0 Q7RTR2 NLRC3_HUMAN "NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)" NLRC3 NOD3 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; intracellular signal transduction [GO:0035556]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of tumor necrosis factor production [GO:0032720]; T cell activation [GO:0042110] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312] ALADALKINRTLTSLR;ISLAENQISNKGAK;TLCELYSWYFR 3 5.4 0.97907 -1.5351 3.28645 0 0 8.29177 0 0 0 0 0 0 0 9.75604 Q7RTR8 T2R42_HUMAN Taste receptor type 2 member 42 (T2R42) (Taste receptor type 2 member 55) (T2R55) TAS2R42 TAS2R55 Homo sapiens (Human) sensory perception of taste [GO:0050909] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] TLYDKLSILK;TPNPLPL 2 5.4 0.96741 -1.3213 0 6.96428 0 0 0 6.90509 14.3271 14.7537 0 0 0 0 Q7RTS3 PTF1A_HUMAN Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48) PTF1A BHLHA29 PTF1P48 Homo sapiens (Human) amacrine cell differentiation [GO:0035881]; cerebellum development [GO:0021549]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; neuron fate commitment [GO:0048663]; pancreas development [GO:0031016]; regulation of DNA-templated transcription [GO:0006355]; regulation of neural retina development [GO:0061074]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GLSGAAAAAAR 1 3.4 0.93598 -0.51963 0 0 0 10.9136 0 0 0 0 0 0 0 0 Q7RTS5 OTOP3_HUMAN Proton channel OTOP3 (Otopetrin-3) OTOP3 Homo sapiens (Human) proton transmembrane transport [GO:1902600] membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; proton channel activity [GO:0015252] HFSLLLR 1 1.2 0.91156 -0.32315 0 0 0 5.80056 0 0 0 0 0 6.0703 0 0 Q7RTS7 K2C74_HUMAN "Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)" KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 Homo sapiens (Human) intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] keratin filament binding [GO:1990254]; structural constituent of skin epidermis [GO:0030280] AVGSLASYCAAGR;DLDLDSIIAEVR;FASFIDK;FASFIDKVR;RYEVEINRR;TTAENEFVVLK 6 10.2 0.89686 -0.2357 0 0 0 0 0 0 0 0 0 0 0 10.0444 Q7RTS9 DYM_HUMAN Dymeclin (Dyggve-Melchior-Clausen syndrome protein) DYM Homo sapiens (Human) bone development [GO:0060348]; Golgi organization [GO:0007030] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] enzyme binding [GO:0019899] SLAGLWTVFTLGGVGSK 1 3.5 0.78529 0.024957 0 0 0 0 0 0 0 2.52218 0 0 7.45311 0 Q7RTT6 SSX6_HUMAN Putative protein SSX6 SSX6P SSX6 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] ASEKRSK;KLCPPGK 2 7.4 0.78367 0.024624 0 0 0 0 0 0 0 0 0 0 0 10.384 Q7RTU1 TCF23_HUMAN Transcription factor 23 (TCF-23) (Class A basic helix-loop-helix protein 24) (bHLHa24) TCF23 BHLHA24 Homo sapiens (Human) cell differentiation [GO:0030154]; decidualization [GO:0046697]; developmental process [GO:0032502]; muscle organ development [GO:0007517]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416]" SWSNQRWSRATPGPR 1 7 0.85036 -0.075302 0 10.4155 0 0 0 0 0 0 0 0 0 0 Q7RTU5 ASCL5_HUMAN Achaete-scute homolog 5 (ASH-5) (hASH5) (Class A basic helix-loop-helix protein 47) (bHLHa47) ASCL5 BHLHA47 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PMGAAER;VETLRAAIRYIK 2 6.8 0.12775 0.35765 11.4034 0 0 0 0 0 0 0 0 9.55436 0 0 Q7RTU9 STRC_HUMAN Stereocilin STRC Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; protein localization [GO:0008104] cell surface [GO:0009986]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426] AAMGKAK;EAAPHFLQGLLGLLTPTGELGSK;EAAQGFLTLMLQGK;QQSWEQSR;STAWGLQDWSRPSWSLVLTISFLGHLL 5 4.5 0.95348 -0.78183 6.28586 4.91179 0 0 0 0 0 0 11.9368 0 7.53691 11.59 Q7RTV3 ZN367_HUMAN Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) ZNF367 ZFF29 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFVQSGQLK;EQRTPTLK;HQAADNK 3 6.9 0.9734 -2.4759 0 0 0 0 0 0 9.39605 0 0 10.7099 11.3907 0 Q7RTV5 PXL2C_HUMAN Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1) PRXL2C AAED1 C9orf21 Homo sapiens (Human) positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycolytic process [GO:0045821] LGMKRGEEIASSGQSPHIK 1 8.4 0.44341 0.19341 0 0 0 0 0 0 12.4618 0 0 0 0 0 Q7RTW8 OTOAN_HUMAN Otoancorin OTOA Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; multicellular organism growth [GO:0035264]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] IGTLLCSTHVLAEFK;LLEDLRKTDAQQFR;MGNSITYR;MLDKDLMPYFQPSAIK 4 5 0.9806 -1.6623 12.9459 0 7.45828 8.9089 0 0 0 0 0 0 7.60607 7.14985 Q7RTX7 CTSR4_HUMAN Cation channel sperm-associated protein 4 (CatSper4) CATSPER4 Homo sapiens (Human) establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] AIRFNQEQESEVLNR;FFINEINIPSINYTLR 2 6.6 0.91778 -0.40899 6.56174 0 0 8.60166 0 0 0 0 0 0 0 0 Q7RTY1 MOT9_HUMAN Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; urate metabolic process [GO:0046415] plasma membrane [GO:0005886] carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] IAPEDLPDK;IAPEDLPDKYSIYNEK 2 3.1 0.95411 -0.90709 0 0 0 13.743 0 0 0 0 12.445 0 0 15.4831 Q7RTY3 PRS45_HUMAN "Putative serine protease 45 (EC 3.4.21.-) (Serine protease 45, pseudogene) (Testis serine protease 5)" PRSS45P PRSS45 TESSP5 Homo sapiens (Human) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] VGTQCWVTGWSQVKQR 1 6.2 0.91529 -0.43101 10.6263 0 0 0 0 0 0 0 0 0 0 0 Q7RTY7 OVCH1_HUMAN Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] AILHDVCGIPPFSPQWLSR;GAFGISYIVLKVLGPK;GLLASAGLLLLLVIGHPRSLGLK;IQVPADLVPAK;VVTAAHCLDSLSEK 5 7.3 0.95134 -0.69581 0 8.28573 2.95474 8.11754 0 0 3.69019 0 0 6.69223 0 11.3295 Q7RTY8 TMPS7_HUMAN Transmembrane protease serine 7 (EC 3.4.21.-) (Matriptase-3) TMPRSS7 Homo sapiens (Human) proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] CDGTVDCPDGSDEEGCTCSR;ESREFLSVSRTVQQVINLVYTTSAFSK;FRITNIEFLPEYRQK 3 8.6 0.29312 0.25308 0 8.60722 0 0 0 8.99101 0 0 0 0 0 0 Q7RTY9 PRS41_HUMAN Serine protease 41 (EC 3.4.21.-) (Testis serine protease 1) (TESSP-1) PRSS41 TESSP1 Homo sapiens (Human) proteolysis [GO:0006508] extracellular region [GO:0005576]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] serine-type endopeptidase activity [GO:0004252] MGARGALLLALLLARAGLGKPGELGALQAGPGAAR;VQDIIVNPDALGVLR 2 15.7 0.75382 0.075267 0 0 0 0 11.3987 0 0 0 0 5.23806 0 0 Q7RTZ1 OVCH2_HUMAN Ovochymase-2 (EC 3.4.21.-) (Oviductin) OVCH2 OVTN Homo sapiens (Human) fertilization [GO:0009566]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] LISRNKLILLLGIVFFER;NKLILLLGIVFFERGK 2 3.5 0.095238 0.37329 0 0 0 3.82253 2.57383 0 0 4.70879 0 0 0 0 Q7Z2D5 PLPR4_HUMAN Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) PLPPR4 KIAA0455 LPPR4 PHP1 PRG1 Homo sapiens (Human) "axonogenesis [GO:0007409]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; lipid import into cell [GO:0140354]; phospholipid metabolic process [GO:0006644]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal transduction [GO:0007165]" glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] phosphatidate phosphatase activity [GO:0008195] DSESCESLK;SIEMRSSSEPSR 2 2.8 0.95259 -0.76455 0 0 6.26634 0 0 8.70867 0 8.83649 0 0 0 0 Q7Z2E3 APTX_HUMAN Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) APTX AXA1 Homo sapiens (Human) DNA ligation [GO:0006266]; regulation of protein stability [GO:0031647]; single strand break repair [GO:0000012] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA 5'-adenosine monophosphate hydrolase activity [GO:0033699]; DNA-3'-diphospho-5'-guanosine diphosphatase [GO:0120108]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mismatched DNA binding [GO:0030983]; phosphoglycolate phosphatase activity [GO:0008967]; phosphoprotein binding [GO:0051219]; polynucleotide 3'-phosphatase activity [GO:0046403]; single-strand break-containing DNA binding [GO:1990165]; single-stranded DNA binding [GO:0003697] ITDKKCSR;VKQVGVNPTSIDSVVIGK;VTVRDGMPELLKLPLR 3 11.8 0.46293 0.1908 0 0 0 0 0 0 0 8.31646 0 0 0 0 Q7Z2E3 APTX_HUMAN Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) APTX AXA1 Homo sapiens (Human) DNA ligation [GO:0006266]; regulation of protein stability [GO:0031647]; single strand break repair [GO:0000012] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA 5'-adenosine monophosphate hydrolase activity [GO:0033699]; DNA-3'-diphospho-5'-guanosine diphosphatase [GO:0120108]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mismatched DNA binding [GO:0030983]; phosphoglycolate phosphatase activity [GO:0008967]; phosphoprotein binding [GO:0051219]; polynucleotide 3'-phosphatase activity [GO:0046403]; single-strand break-containing DNA binding [GO:1990165]; single-stranded DNA binding [GO:0003697] ITDKKCSR;MQPCTSSCDQPGF;VKQVGVNPTSIDSVVIGK 3 20.3 0.98033 -1.6688 0 0 10.3467 3.67423 0 0 10.1765 0 0 0 0 0 Q7Z2G1 H2BWT_HUMAN Histone H2B type W-T (H2B histone family member W testis-specific) (H2B.W histone 1) H2BW1 H2BFWT TH2B-175 Homo sapiens (Human) "chromosome, telomeric region [GO:0000781]; nuclear membrane [GO:0031965]; nucleosome [GO:0000786]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] EANSTTSQK;QTITAWETRMAVR;RCHSNCR;TEVPRLPR 4 21.1 0.9777 -1.9522 11.0672 7.32391 0 0 0 0 0 0 0 0 7.44369 0 Q7Z2H8 S36A1_HUMAN Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1) SLC36A1 PAT1 Homo sapiens (Human) alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]; taurine transmembrane transport [GO:0015734] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]; taurine transmembrane transporter activity [GO:0005368] LYMLSFLPFLVLLVFIRNLR 1 4.2 0.81758 -0.01737 0 0 0 0 2.94011 0 0 0 0 0 0 0 Q7Z2K6 ERMP1_HUMAN Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) ERMP1 FXNA KIAA1815 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; proteolysis [GO:0006508] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] GAGTGLSEVRAALGLALYLIALR;TFHDLEGNAVKR 2 3.9 0.95521 -0.86143 7.3557 0 0 5.37671 0 0 0 8.20031 0 0 0 0 Q7Z2K8 GRIN1_HUMAN G protein-regulated inducer of neurite outgrowth 1 (GRIN1) GPRIN1 KIAA1893 Homo sapiens (Human) neuron projection development [GO:0031175] growth cone [GO:0030426]; plasma membrane [GO:0005886] phosphoprotein binding [GO:0051219] APSPPSR;MDFKSSKQADSTSIGK;TYTVSPRK;VDPLCSSK;VVSTPGK 5 4.6 0.97283 -2.605 0 0 0 0 0 0 0 0 0 10.6562 0 12.3742 Q7Z2Q7 LRR70_HUMAN Leucine-rich repeat-containing protein 70 (Synleurin) LRRC70 UNQ1891/PRO4337 Homo sapiens (Human) positive regulation of response to cytokine stimulus [GO:0060760] plasma membrane [GO:0005886] HLILSHNDLENLNSDTFSLLKNLIYLKLDR 1 4.8 0.68427 0.16282 0 0 0 4.60377 0 0 0 0 0 0 0 0 Q7Z2T5 TRM1L_HUMAN TRMT1-like protein (EC 2.1.1.-) TRMT1L C1orf25 TRM1L MSTP070 Homo sapiens (Human) tRNA N2-guanine methylation [GO:0002940] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA binding [GO:0000049] SFDFIHLDPFGTSVNYLDSAFR;TEYYKELAAR 2 4.4 0.91735 -0.42787 10.1634 0 0 0 0 0 0 0 0 6.24774 0 0 Q7Z2V1 TNT_HUMAN Protein TNT C16orf82 Homo sapiens (Human) SLVPGQHCSPSHTR 1 6.5 0.78772 0.017247 0 3.32337 0 0 0 0 0 0 0 0 0 0 Q7Z2W4 ZCCHV_HUMAN Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleus [GO:0005634] cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] ASLEDAPVDDLTR;ASMKNFK;DAIYSHK;GVVPFQAGSR;IQDAGPASR;VDDHDSEEICLDHLCKGCPLNGSCSK 6 8 0.022642 0.63021 0 0 9.74002 0 0 0 0 0 0 10.1025 10.7893 0 Q7Z2W7 TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to cold [GO:0009409]; thermoception [GO:0050955] endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; metal ion binding [GO:0046872] ENYLVKINTKANDTSEEMR;IPIVCFAQGGGK;RWESADLQEVMFTALIK;YISERTIQDSNYGGK 4 5.7 0.98051 -1.5992 0 0 0 0 0 0 10.4005 11.9128 5.71048 8.30629 0 0 Q7Z2W9 RM21_HUMAN "Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21)" MRPL21 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IIMRFRK 1 3.4 0.96456 -1.1695 11.8921 0 0 0 0 0 0 0 0 0 0 0 Q7Z2Y5 NRK_HUMAN Nik-related protein kinase (EC 2.7.11.1) NRK Homo sapiens (Human) positive regulation of JNK cascade [GO:0046330] cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EVTDLGHLPDPTGIFSLDK;KTPLPEIGRR;NHHSRVYFMTLGKLEELQSNYDV;TTGWGQK 4 3.7 0.97614 -2.2607 0 0 0 0 0 0 0 10.1455 4.65214 10.0599 0 0 Q7Z2Y8 GVIN1_HUMAN Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1) GVINP1 GVIN1 VLIG1 Homo sapiens (Human) cytosol [GO:0005829]; nucleus [GO:0005634] GTP binding [GO:0005525] IINFFHR;QKYWWSLVQTVKQK;QNLPDRDVVR;YCSDNGGEK 4 1.7 0.97494 -3.0876 0 0 11.2799 5.76826 0 6.27413 11.0307 0 0 0 0 0 Q7Z2Z1 TICRR_HUMAN "Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)" TICRR C15orf42 Homo sapiens (Human) DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of DNA-templated DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] DFKTEEELLSYIRENYQK;GLSLSPQSPPER;GVPRTPVR;KSKIECPSPGELDQK;LLHRQIKGR;LMGTWLEDL;QVMEKLLPK;TPKRPGNSTVTSSPPVTPKK;VMLLLDTAGGAARHSRVR 9 6.2 0.97266 -2.6119 8.85 8.27095 0 0 5.79145 7.81526 0 11.1757 13.1418 0 0 9.97714 Q7Z2Z2 EFL1_HUMAN Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) EFL1 EFTUD1 FAM42A Homo sapiens (Human) cytosolic ribosome assembly [GO:0042256]; GTP metabolic process [GO:0046039] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746] IVEHAEK;TLWGDYYINMKAK;VLEERAER 3 2.5 0.96483 -1.1639 0 0 0 0 0 0 0 12.3418 10.9475 0 0 0 Q7Z304 MAMC2_HUMAN MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) nervous system development [GO:0007399] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] GETPTSYTGPK 1 1.6 0.93707 -0.55617 0 9.85223 0 0 0 0 0 0 0 0 0 0 Q7Z309 PBIR2_HUMAN PABIR family member 2 PABIR2 FAM122B Homo sapiens (Human) protein serine/threonine phosphatase inhibitor activity [GO:0004865] HSLEEGLDMVNR 1 4.9 0.87863 -0.14025 0 0 0 0 0 0 0 0 0 0 0 11.4005 Q7Z333 SETX_HUMAN Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) SETX ALS4 KIAA0625 SCAR1 Homo sapiens (Human) "cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA-templated transcription termination [GO:0006353]; double-strand break repair [GO:0006302]; mRNA splice site recognition [GO:0006376]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of DNA-templated transcription [GO:0060566]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]" "axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147] DCVIVTCVR;IQEFHVDGK;KQLIKCMPSEPETIK;LLEENVEHNMISRLPILQLTVQYR;LLTENQR;LLTSQELQMQRQIRPK;LSDCESTDVK;LVMEIIK;QLYPKENDLVFLAPERINEEK;SISVEEFCEIEVK;SLDYVAQLRDHGK;SSNYLSCRTTPAIVPPK;TLMENQHWNQLIQDAQKR;YPYLLLHER 14 7 0.97601 -4.5275 11.3933 5.64313 7.5428 7.78627 7.05039 0 10.7683 9.32353 11.3585 11.9844 10.9716 0 Q7Z340 ZN551_HUMAN Zinc finger protein 551 (Zinc finger protein KOX23) ZNF551 KOX23 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SDLIQHRR 1 1.2 0.83982 -0.043952 0 0 0 0 0 0 0 0 0 11.69 0 0 Q7Z353 HDX_HUMAN Highly divergent homeobox HDX CXorf43 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NEEVKFIENELEIQK 1 2.2 0.88294 -0.17128 9.17 0 0 0 0 7.44195 0 0 0 0 0 0 Q7Z388 D19L4_HUMAN Probable C-mannosyltransferase DPY19L4 (EC 2.4.1.-) (Dpy-19-like protein 4) (Protein dpy-19 homolog 4) DPY19L4 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] ISDIPIPER 1 1.2 0.93725 -0.5418 0 0 0 0 0 0 0 0 0 0 0 11.8288 Q7Z392 TPC11_HUMAN Trafficking protein particle complex subunit 11 TRAPPC11 C4orf41 Homo sapiens (Human) constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] ANEVLENLTQGKMCLVPGK;ESLPVKYHLQNK;QDTQNALKNYR;VLPGDHEYPKCRPK;VLPGDHEYPKCRPKR 5 5 0.96336 -1.0903 0 0 0 0 7.12112 0 8.91758 10.8049 0 0 10.1591 0 Q7Z392 TPC11_HUMAN Trafficking protein particle complex subunit 11 TRAPPC11 C4orf41 Homo sapiens (Human) constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] ANEVLENLTQGKMCLVPGK;DCGEYPSPCECR;QDTQNALKNYR;VLPGDHEYPKCRPK;VLPGDHEYPKCRPKR 5 5.6 0.80949 0.0093225 0 0 0 4.40293 0 0 0 0 0 0 0 0 Q7Z3B3 KANL1_HUMAN KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 CENP-36 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mitochondrial transcription [GO:1903108] histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase binding [GO:0035035] ARWLWTTSVPPQR;ESLKLQGVFSKQTVLK;HKLVSSFLTTAKLSHHQTRPDR;LPNLESLRPR 4 5.5 0.40647 0.20637 0 0 0 0 0 0 7.46189 0 0 9.73796 0 13.0459 Q7Z3C6 ATG9A_HUMAN Autophagy-related protein 9A (APG9-like 1) (mATG9) ATG9A APG9L1 Homo sapiens (Human) autophagosome assembly [GO:0000045]; bone morphogenesis [GO:0060349]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phospholipid scramblase activity [GO:0017128] EPGALGARCWSLYGR;GLSVPAS 2 4.2 0.8875 -0.18594 0 9.1813 0 0 0 0 10.6215 0 0 0 0 0 Q7Z3D4 LYSM3_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 3 LYSMD3 Homo sapiens (Human) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] peptidoglycan binding [GO:0042834] AGRHQNR;EVDRDIEQIVKCTDNK 2 7.5 0.75129 0.081017 0 0 0 0 0 0 5.71315 0 7.05972 0 0 7.62095 Q7Z3D6 GLUCM_HUMAN "D-glutamate cyclase, mitochondrial (EC 4.2.1.48)" DGLUCY C14orf159 UNQ2439/PRO5000 Homo sapiens (Human) glutamate metabolic process [GO:0006536] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] D-glutamate cyclase activity [GO:0047820] GIGHLLCKDELLK 1 2.1 0.95198 -0.71044 0 0 0 0 0 0 0 0 0 9.30891 0 0 Q7Z3E1 PARPT_HUMAN Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase) TIPARP PARP7 Homo sapiens (Human) "androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]" nucleus [GO:0005634] cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779] EVRFMMWNNHYILHNSFFRR;HHTVLPYHWQIK;LIEEANSR;YTMGSHGMR 4 7.5 0.96685 -1.2689 0 0 0 0 0 0 0 0 0 10.8787 5.67903 0 Q7Z3E2 CC186_HUMAN Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) CCDC186 C10orf118 Homo sapiens (Human) insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518] trans-Golgi network [GO:0005802] small GTPase binding [GO:0031267] ALSTQVEELK;DQLIAQDVTAK;KNEKIEFMEDHIK;RESELLLFTERLTSK;TETEKQHMNTIKQLESR 5 7.3 0.97497 -3.2351 0 0 12.1654 0 0 0 0 0 11.7583 0 0 0 Q7Z3E5 ARMC9_HUMAN LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21) ARMC9 KIAA1868 Homo sapiens (Human) cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] LFSNQMR;LKLIKFLALISK 2 2.3 0.96637 -1.2698 0 11.5793 4.18436 0 3.48684 3.11478 0 0 0 0 0 6.30989 Q7Z3F1 LYCHS_HUMAN Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) GPR155 PGR22 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to cholesterol [GO:0071397]; cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane transport [GO:0055085] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765] cholesterol binding [GO:0015485] DLCIRNIVK;KSAFVVLILLITAK;KSAFVVLILLITAKLLVLPLLCR;LKKSAFVVLILLITAK;SAFVVLILLITAKLLVLPLLCR;WKDTQNASQNKIK 6 5.4 0.98015 -2.0405 8.28198 0 0 12.7216 4.59914 0 8.55486 10.0741 0 0 8.78784 13.876 Q7Z3G6 PRIC2_HUMAN Prickle-like protein 2 PRICKLE2 Homo sapiens (Human) "Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] zinc ion binding [GO:0008270] CAACDEIIFADECTEAEGR;LFSSQRK;SSTLGGR;YCNSLDEEEK;YSSYGLPK 5 6 0.95484 -0.79586 0 0 0 5.44238 0 0 10.4785 0 0 9.7465 0 11.3953 Q7Z3H0 PANKY_HUMAN Photoreceptor ankyrin repeat protein (Ankyrin repeat domain-containing protein 33) ANKRD33 C12orf7 PANKY Homo sapiens (Human) skeletal muscle cell differentiation [GO:0035914] cytosol [GO:0005829]; nucleus [GO:0005634] GAWAVPR;GGDTALMLAAQAGHVPLVSLLLNYYVGLDLER 2 8.6 0.92963 -0.48059 0 0 0 0 0 0 0 0 8.91597 0 0 0 Q7Z3I7 ZN572_HUMAN Zinc finger protein 572 ZNF572 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LLVSDSNSFMER 1 2.3 0.80604 0.011627 0 6.72192 0 0 0 0 0 0 0 0 0 0 Q7Z3J2 VP35L_HUMAN VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein) VPS35L C16orf62 101F10.2 Homo sapiens (Human) endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886] LTCMIRGIGDPLVSVYARAYLCR;TLAKDEALKR;TMVKTLEYIKK 3 4.6 0.97969 -1.5471 0 6.69167 5.34188 0 0 7.59716 0 0 0 7.95907 10.2201 0 Q7Z3J3 RGPD4_HUMAN RanBP2-like and GRIP domain-containing protein 4 RGPD4 RGP4 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] AVVSPPK;DLVLKIAELLCK;DVGQWKER;EMDPRAHR;EYIGRSVHYWK;GEAGQNLLEMMACDR;KCELSKNSDIEQSSDSK;LRLLVQHEINTLR;NLFHFGESTTGSNFSFK;QKSWWDAVCTLIHR;QLCTERQKSWWDAVCTLIHR;SVMQELENYSEGDPLYKNGSLRNADSEIK;VLPLLKIIK;YDVGAIR;YSLSPSKSYK 15 10.4 0.91709 -0.41798 0 9.25399 0 0 8.39356 0 9.57911 0 0 5.82255 0 0 Q7Z3K3 POGZ_HUMAN Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003 Homo sapiens (Human) cell division [GO:0051301]; double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ISYEWAVR;KPKQLEGLKPGTKVTIR;RAVAHTLPKDVAENAGLFIDFVQR;SLEGGFKISYEWAVR;VTEALRGHMCYCCPEMVEYQK;YSTCCSR 6 6 0.96385 -1.1107 10.8813 0 12.0058 0 9.7773 0 9.09218 0 0 0 0 11.177 Q7Z3K6 MIER3_HUMAN Mesoderm induction early response protein 3 (Mi-er3) MIER3 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] NFSSEIEDLEK;YCCNGKASQEGMTAWTEEECR 2 5.8 0.91773 -0.42488 0 0 0 0 0 3.9594 0 0 0 6.08591 0 0 Q7Z3S7 CA2D4_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] CACNA2D4 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; detection of light stimulus involved in visual perception [GO:0050908] voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] EVSFADRMK;FSEDMENMLRR;YKDVESSLKIEEVDGLELVR 3 3.5 0.67503 0.16664 12.1027 0 0 0 0 0 0 0 0 0 0 9.41986 Q7Z3T8 ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) ZFYVE16 KIAA0305 Homo sapiens (Human) endosomal transport [GO:0016197]; protein targeting to lysosome [GO:0006622]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]; vesicle organization [GO:0016050] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] "1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" AAVSDLDK;DIFRLFITIYK;LDDLSLPSNPFLCGILIQKLEIPWAKVFPMR;TLKSNGMNKIGLR 4 4.1 0.97356 -1.416 8.68867 9.69 0 0 0 0 0 7.27268 0 0 9.52648 0 Q7Z3T8 ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) ZFYVE16 KIAA0305 Homo sapiens (Human) endosomal transport [GO:0016197]; protein targeting to lysosome [GO:0006622]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]; vesicle organization [GO:0016050] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] "1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" AAVSDLDK;VCVVCYETISKGEC 2 2.7 0.92137 -0.44585 0 0 3.53506 0 0 0 0 0 0 0 0 0 Q7Z3U7 MON2_HUMAN Protein MON2 homolog (Protein SF21) MON2 KIAA1040 SF21 Homo sapiens (Human) Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062] EWGAEALTSLIK;LLENMQSDLRALSLECK;QHASSGK;QQVTEIIFVLKAVSTLIDSLK;VLQNIIKTLRVPLSLK 5 4.3 0.94159 -0.60497 0 0 12.2571 7.95542 0 0 0 8.22173 0 9.13712 0 11.9073 Q7Z3V4 UBE3B_HUMAN Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) UBE3B Homo sapiens (Human) protein polyubiquitination [GO:0000209]; regulation of postsynapse assembly [GO:0150052]; ubiquitin-dependent protein catabolic process [GO:0006511] glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; postsynaptic density [GO:0014069] ubiquitin protein ligase activity [GO:0061630] IARKLLFLFR;IKEDNER;ISYIHLMAHFR;LTVLESHDMLRK;SFLCRSR;TIPVTNENK;VDSAEVQK 7 6 0.97688 -4.8826 0 3.36947 0 11.0358 0 0 9.79388 9.4744 0 9.99718 0 0 Q7Z3V4 UBE3B_HUMAN Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) UBE3B Homo sapiens (Human) protein polyubiquitination [GO:0000209]; regulation of postsynapse assembly [GO:0150052]; ubiquitin-dependent protein catabolic process [GO:0006511] glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; postsynaptic density [GO:0014069] ubiquitin protein ligase activity [GO:0061630] IARKLLFLFR;IKEDNER;SFLCRSR;SWYDWQLSR 4 13.5 0.8468 -0.066103 0 7.62432 0 0 0 0 0 0 0 0 0 0 Q7Z3V5 ZN571_HUMAN Zinc finger protein 571 ZNF571 HSPC059 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFISNSNLIQHQRIHTGEKPYK;AFLCASQLNEHQR;EIYEMESLQWENMGKR 3 8.4 0.34193 0.23874 0 0 0 0 0 0 0 10.3658 7.81948 9.95222 0 0 Q7Z3Y9 K1C26_HUMAN "Keratin, type I cytoskeletal 26 (Cytokeratin-26) (CK-26) (Keratin-25B) (K25B) (Keratin-26) (K26) (Type I inner root sheath-specific keratin-K25irs2)" KRT26 KRT25B Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] CEPGSSR;ISNITVEQR;VTMQNLNDR 3 5.3 0.87527 -0.12769 7.97011 0 0 0 9.57491 0 0 0 0 0 9.64324 0 Q7Z3Z2 RD3_HUMAN Protein RD3 (Retinal degeneration protein 3) RD3 C1orf36 Homo sapiens (Human) negative regulation of guanylate cyclase activity [GO:0031283]; protein transport [GO:0015031]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; rod photoreceptor outer segment [GO:0120200] MKQEEEAHKLTR;QEEEAHKLTR 2 6.2 0.97906 -1.9025 0 0 0 0 0 7.83137 0 0 0 0 0 0 Q7Z3Z3 PIWL3_HUMAN Piwi-like protein 3 PIWIL3 Homo sapiens (Human) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186] piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] DYSIVKELAK;ELEICLKAALDVWCK 2 2.8 0.98086 -1.7481 0 0 0 0 0 0 8.9526 0 0 0 0 0 Q7Z3Z4 PIWL4_HUMAN Piwi-like protein 4 PIWIL4 HIWI2 PIWI Homo sapiens (Human) cell differentiation [GO:0030154]; epithelial structure maintenance [GO:0010669]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulation of translation [GO:0006417]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; piP-body [GO:0071547] piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] IAMQMTCK;LEEKVTELSSETQR;LLFSADVSYK;LSPSGRQQR;LVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLR;SLMVVGIDVCK;TVQNPPLGTVVDSEATR;YLSSDCPVPSQCVLAR 8 13.8 0.97489 -3.2765 11.8877 0 0 7.04603 0 0 0 0 13.3032 0 0 10.5361 Q7Z401 MYCPP_HUMAN C-myc promoter-binding protein (DENN domain-containing protein 4A) DENND4A IRLB MYCPBP Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085] GSADCLPK;GVAEKASK;ISLESSASLEGSLSKFALPGK;LHMIDLEIQEAFLFFMASILKGYR;LQENFCTR;SIQIPANRSK;SKSYTKSEEKPR;YSSIPQMWSRCLLR 8 5.6 0.97517 -3.3756 7.15623 0 3.45312 0 0 10.9618 10.4794 0 5.03716 0 7.0798 0 Q7Z402 TMC7_HUMAN Transmembrane channel-like protein 7 TMC7 Homo sapiens (Human) sensory perception of mechanical stimulus [GO:0050954] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ion channel inhibitor activity [GO:0008200]; mechanosensitive monoatomic ion channel activity [GO:0008381] AREMTTHLELWREDIR;CVFMRLATICVLVFTLGSK;DIQETQMKYLSEWDQWK;LTEAQRDMRN;TSEETIR;YLSEWDQWKR 6 9.7 0.97907 -1.989 10.896 8.38672 6.77926 0 0 9.55909 10.5191 9.8846 0 0 0 9.44166 Q7Z403 TMC6_HUMAN Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) TMC6 EVER1 EVIN1 Homo sapiens (Human) intracellular zinc ion homeostasis [GO:0006882]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] mechanosensitive monoatomic ion channel activity [GO:0008381] ASRLQQDNIR;KTSLLANCQAPR;TLDTMYEAGRVWVR;TPRGKWR;TVQLRCR 5 6.2 0.97502 -3.1557 0 0 12.543 0 0 0 0 0 0 0 10.558 9.60931 Q7Z404 TMC4_HUMAN Voltage-gated chloride channel TMC4 (Transmembrane channel-like protein 4) TMC4 Homo sapiens (Human) extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated chloride channel activity [GO:0005247] AVALTSTKPAL;DQVVYGSGTK;LRQRIILYELK;TLGQQAR 4 5.5 0.98026 -1.8018 0 5.29249 0 0 0 0 0 3.35445 0 8.36383 9.38858 12.2223 Q7Z406 MYH14_HUMAN "Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)" MYH14 KIAA2034 FP17425 Homo sapiens (Human) actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitochondrion organization [GO:0007005]; neuronal action potential [GO:0019228]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519]; vocalization behavior [GO:0071625] actomyosin [GO:0042641]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] DEAGEERRR;EQADFALEALAK;FDQLLAEEK;ICRQGFPNR;KFDQLLAEEK;LQLEKVTTEAK;LVLDQLR;QLLQANPILEAFGNAK;TETVDRLERGR;TIRLSKELSSTEAQLHDAQELLQEETR;TLEEETRIHEAAVQELR;TQHERDLQGR;TVKNDNSSR;VAQEQGGHPKFQRPRHLR 14 8.3 0.97642 -4.7054 9.201 0 12.4731 0 12.6004 8.91232 0 0 10.7365 0 9.54869 9.36822 Q7Z407 CSMD3_HUMAN CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) regulation of dendrite development [GO:0050773] plasma membrane [GO:0005886] ELAVVTHRVKK;IESSSNTMHLAFR;ILVKDPRPALGTPSPK;IVNGSHYEYKTK;LEGTSEIICLGGGRR;LVGKSSAVCR;TSSTQCSSVPEPRFGR 7 2.5 0.97537 -3.3907 0 4.41893 0 9.53101 11.3709 0 0 0 0 8.16481 0 0 Q7Z408 CSMD2_HUMAN CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) maintenance of postsynaptic density structure [GO:0099562]; postsynaptic density assembly [GO:0097107] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] VGGDPGNIQCNK 1 5.3 0.80954 0.0092515 0 0 0 6.75916 7.4031 0 0 0 0 0 0 0 Q7Z408 CSMD2_HUMAN CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) maintenance of postsynaptic density structure [GO:0099562]; postsynaptic density assembly [GO:0097107] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] CGCPAGR;GTILSPGFPEPYLNSLNCVWK;ITCLGGRRR;LLESDPESIGR;QPAMLRVTGFQVANSK;RGFNITFTTFR;WSSDHAYNR 7 2.3 0.97963 -1.8472 7.62979 0 0 7.79727 11.527 0 11.4281 7.19928 0 10.025 0 10.6691 Q7Z410 TMPS9_HUMAN Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3] TMPRSS9 Homo sapiens (Human) proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] KPGVYTRITRLK 1 1.1 0.87124 -0.095841 0 0 6.36338 0 0 0 0 0 0 0 0 0 Q7Z417 NUFP2_HUMAN FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) NUFIP2 KIAA1321 PIG1 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] RNA binding [GO:0003723] GKPAVGDMLRK;IVPKISYASK 2 3 0.97865 -2.0917 0 0 0 0 0 0 0 0 0 7.99532 9.14837 11.9952 Q7Z419 R144B_HUMAN E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein) RNF144B IBRDC2 P53RFP Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LKFEREVHLDPYR 1 4.3 0.97642 -1.4676 0 0 0 0 0 12.287 0 0 0 0 0 0 Q7Z429 LFG1_HUMAN Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3) GRINA LFG1 NMDARA1 TMBIM3 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of neuron apoptotic process [GO:0043524] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] calcium channel activity [GO:0005262]; transmembrane transporter binding [GO:0044325] KVFLVLTLQLSVTLSTVSVFTFVAEVK 1 7.3 0.37924 0.22075 0 8.28702 0 0 0 0 0 0 0 0 0 0 Q7Z442 PK1L2_HUMAN Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) detection of mechanical stimulus [GO:0050982] membrane [GO:0016020] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246] ARPEDQRR;EQPGSLSQTRHSRPAQALPK;IMSFPKSPFPAR;NLSENIEILLPR;SAVGLVLLVLALRLR;YYQLSEEGEIVDLLLMKILSFLGIK 6 3.7 0.97423 -2.4458 0 5.96236 4.61277 0 0 4.62848 0 0 9.59475 9.40344 0 10.7817 Q7Z443 PK1L3_HUMAN Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3) PKD1L3 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915] cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium channel activity [GO:0005262]; calcium-activated cation channel activity [GO:0005227]; carbohydrate binding [GO:0030246]; pH-gated monoatomic ion channel activity [GO:0160128] WWIGQNVMPLK;WWIGQNVMPLKK 2 0.7 0.72681 0.12351 0 4.99386 0 0 0 0 0 11.4444 0 0 0 0 Q7Z449 CP2U1_HUMAN Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP2U1 Homo sapiens (Human) cytochrome metabolic process [GO:1903604]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743] "arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]" EALVQQAEVFSDRPR;GTLILPNLWSVHR;IIEEFKYVKAEMQK 3 7.7 0.95215 -0.72332 0 0 0 0 0 9.52664 0 0 11.5886 0 0 0 Q7Z460 CLAP1_HUMAN CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) CLASP1 KIAA0622 MAST1 Homo sapiens (Human) "astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903]" basal cortex [GO:0045180]; cell cortex [GO:0005938]; centrosomal corona [GO:0031592]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; spindle microtubule [GO:0005876] dystroglycan binding [GO:0002162]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] FKAQIGTVLPSLIDR;HVGERVRADLSK;IITWTTEPK;SANPAGAGSRSSSPGKLLGSGYGGLTGGSSR;TLEAHKDSHK;TLSRVELK 6 5.5 0.97841 -1.9781 0 0 5.74672 0 0 0 0 13.232 0 10.9661 0 10.2124 Q7Z478 DHX29_HUMAN ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) DHX29 DDX29 Homo sapiens (Human) formation of translation preinitiation complex [GO:0001731]; positive regulation of translational initiation [GO:0045948]; ribosome assembly [GO:0042255] cytosolic small ribosomal subunit [GO:0022627]; eukaryotic 43S preinitiation complex [GO:0016282] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; cadherin binding [GO:0045296]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation activator activity [GO:0008494]; translation initiation factor activity [GO:0003743] ARQEGGYRSEITYCR;CNIVCTQPRR;ISHQQNERK;LTPLGQHLAALPVNVKIGK;VLIDSVLRK 5 4.5 0.95595 -0.84362 0 0 0 0 0 0 0 7.20036 0 10.2295 8.46082 0 Q7Z494 NPHP3_HUMAN Nephrocystin-3 NPHP3 KIAA2000 Homo sapiens (Human) "atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]; Wnt signaling pathway [GO:0016055]" ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576] DLGLLSQAIVPLQRSLEIR;DTPDNAR;LDTENKR;LLEEFPRWLEKLSAR;LSKEQEK;LSKEQEKK;SFKIHQKAIK;VGETLKNLAVLSYEGGDFEK 8 6.5 0.9748 -3.8588 0 0 6.79792 0 0 0 11.35 11.2829 12.6128 8.08725 8.50462 7.12029 Q7Z4F1 LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 (LRP-10) LRP10 MSTP087 SP220 UNQ389/PRO724 Homo sapiens (Human) endocytosis [GO:0006897]; inner ear development [GO:0048839]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle receptor activity [GO:0005041] CRHCQPGNFR 1 1.4 0.88902 -0.18738 0 0 0 0 0 0 0 0 0 7.60237 0 0 Q7Z4H3 HDDC2_HUMAN 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) HDDC2 C6orf74 NS5ATP2 CGI-130 Homo sapiens (Human) 5'-deoxynucleotidase activity [GO:0002953]; metal ion binding [GO:0046872] EEEAMKQITQLLPEDLR;LVGQLKRVPR 2 13.2 0.77572 0.045672 0 10.7302 0 0 0 5.04614 0 0 0 0 0 0 Q7Z4H4 ADM2_HUMAN Protein ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)] ADM2 AM2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; feeding behavior [GO:0007631]; negative regulation of blood pressure [GO:0045776]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate [GO:0010460]; protein phosphorylation [GO:0006468]; regulation of systemic arterial blood pressure [GO:0003073] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877] HPAPRPVVWKLHR;QHSGPRRHSGPR 2 16.9 0.97936 -1.5335 0 0 0 0 0 0 0 0 9.42377 4.05563 0 0 Q7Z4H7 HAUS6_HUMAN HAUS augmin-like complex subunit 6 HAUS6 DGT6 FAM29A KIAA1574 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] microtubule binding [GO:0008017] CIARCHFARSR;IKDDLTTIRHSVVEK;KMEPYDDHSNMEEK;LSDLKHMR;NLRSECIGLENQIK;QDLECLAFTK;SILCQYPASLPDAHK 7 9.1 0.97507 -3.8924 0 10.1762 0 0 7.14241 0 0 10.2655 8.1046 0 0 0 Q7Z4H8 PLGT3_HUMAN Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-) POGLUT3 KDELC2 UNQ1904/PRO4350 Homo sapiens (Human) protein O-linked glycosylation via serine [GO:0018242] endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788] EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] ENPQLLDAGITGYFFFQEK;LQLVQLSK;SPAGETPFK 3 7.1 0.95527 -0.85973 0 0 0 0 0 0 0 0 0 0 2.93471 0 Q7Z4H8 PLGT3_HUMAN Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-) POGLUT3 KDELC2 UNQ1904/PRO4350 Homo sapiens (Human) protein O-linked glycosylation via serine [GO:0018242] endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788] EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] ENPQLLDAGITGYFFFQEK;LQLVQLSK;MVELFIFLFLLGETPFKVVVKSLSPK 3 13 0.68409 0.16504 0 0 0 0 0 0 0 0 0 0 8.53084 0 Q7Z4I7 LIMS2_HUMAN LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cholangiocyte proliferation [GO:1990705]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte proliferation [GO:1904055]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural precursor cell proliferation [GO:0061351]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] ELTAEARELK;VVNALGK 2 5 0.97954 -2.0432 0 11.4356 0 0 0 0 0 0 0 0 0 0 Q7Z4K8 TRI46_HUMAN "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" TRIM46 TRIFIC Homo sapiens (Human) anterograde synaptic vesicle transport [GO:0048490]; axonogenesis [GO:0007409]; microtubule bundle formation [GO:0001578]; negative regulation of axon extension [GO:0030517]; neuron migration [GO:0001764]; positive regulation of anterograde dense core granule transport [GO:1901953]; protein localization to axon [GO:0099612]; regulation of protein localization [GO:0032880] axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoskeleton [GO:0005856]; main axon [GO:0044304]; proximal neuron projection [GO:1990769] zinc ion binding [GO:0008270] GCTECRATFCNECFK;GLGAVLEEK;ITPVLSAYQALKDKLTK 3 5.4 0.97714 -1.5231 0 0 12.3365 0 0 0 3.98514 0 0 10.3802 0 0 Q7Z4L5 TT21B_HUMAN Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) TTC21B IFT139 KIAA1992 Nbla10696 Homo sapiens (Human) Bergmann glial cell differentiation [GO:0060020]; cerebellar Purkinje cell differentiation [GO:0021702]; cilium assembly [GO:0060271]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; negative regulation of eating behavior [GO:1903999]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; regulation of intraciliary retrograde transport [GO:1905799]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991] chromatin binding [GO:0003682] DILDKARASLRP;MLYITCFREIAERMANPR;VLQHALAHEPVNELSALMEDGR 3 4 0.87577 -0.12654 0 10.364 0 7.88649 0 0 0 0 0 7.78575 0 0 Q7Z4L9 PPR42_HUMAN Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) PPP1R42 LRRC67 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815] actin binding [GO:0003779]; dynein complex binding [GO:0070840]; tubulin binding [GO:0015631] ITHINFSDK;ITHINFSDKNIDAIEDLSLCK 2 6.8 0.96134 -1.0609 0 0 0 0 0 0 7.7666 0 0 0 0 0 Q7Z4N2 TRPM1_HUMAN Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1) TRPM1 LTRPC1 MLSN MLSN1 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to light stimulus [GO:0071482]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; visual perception [GO:0007601] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; monoatomic cation transmembrane transporter activity [GO:0008324] ECIFVIPSMKDSNR;EILMSEPGK;EILMSEPGKLSQK;IRVTSERVENMSMR;KGDEENEHKK;SISNQVWK;TLYNNLFGPKRPK 7 4.4 0.95549 -0.86057 7.09001 9.93003 0 0 0 0 3.19462 0 9.73493 0 0 0 Q7Z4P5 GDF7_HUMAN Growth/differentiation factor 7 (GDF-7) GDF7 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching morphogenesis of an epithelial tube [GO:0048754]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; forebrain morphogenesis [GO:0048853]; gland morphogenesis [GO:0022612]; midbrain development [GO:0030901]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of tendon cell differentiation [GO:2001051]; reproductive structure development [GO:0048608]; roof plate formation [GO:0021509]; spinal cord association neuron differentiation [GO:0021527] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802] AAGSGFR;ESLFREIR;TLAQAAGAAAVPAAAVPRAR 3 7.8 0.97796 -1.5121 0 9.67186 0 0 0 10.6628 0 0 0 0 0 11.442 Q7Z4Q2 HEAT3_HUMAN HEAT repeat-containing protein 3 (Symportin Syo1) (hsSyo1) HEATR3 Homo sapiens (Human) erythrocyte maturation [GO:0043249]; protein import into nucleus [GO:0006606]; ribosomal large subunit biogenesis [GO:0042273] unfolded protein binding [GO:0051082] FIAYQETVEK 1 1.5 0.89837 -0.23315 0 0 0 0 8.13453 0 0 0 0 0 0 0 Q7Z4S6 KI21A_HUMAN Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) KIF21A KIAA1708 KIF2 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; cortical microtubule organization [GO:0043622]; microtubule-based movement [GO:0007018]; regulation of axon guidance [GO:1902667]; regulation of microtubule depolymerization [GO:0031114]; regulation of microtubule polymerization [GO:0031113] axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; presynapse [GO:0098793] ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] ASQQINALRSEITRLQMELMEYK;EIEDLRAK;GIINPFPASK;GLQAAQK;KKSVAGK;MRIPVAR;QYEEKLMMLQHKIR;RATHVPYR;VNAQFLELYNEEVLDLFDTTR;VTDIIMQK 10 6.9 0.97673 -5.5623 0 0 0 7.29057 0 11.6309 7.55888 9.18301 0 0 0 11.0393 Q7Z4S9 SH2D6_HUMAN SH2 domain-containing protein 6 SH2D6 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] AQEEDEEENK;VVPGPPK 2 5.1 0.85274 -0.080237 0 0 6.11649 0 0 7.79181 0 5.83711 0 0 0 0 Q7Z4T8 GLTL5_HUMAN Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15) GALNTL5 GALNT15 Homo sapiens (Human) spermatid development [GO:0007286] Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902] metal ion binding [GO:0046872] KSQEPLSAWSPGKK 1 3.2 0.76403 0.062645 0 0 0 0 0 0 0 0 0 8.09993 0 0 Q7Z4T9 CFA91_HUMAN Cilia- and flagella-associated protein 91 (CFAP91) (AMY-1-associating protein expressed in testis 1) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) (Protein MAATS1) CFAP91 AAT1 C3orf15 MAATS1 Homo sapiens (Human) axonemal central apparatus assembly [GO:1904158]; cell differentiation [GO:0030154]; cilium movement [GO:0003341]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; mitochondrion [GO:0005739]; motile cilium [GO:0031514] LPTPTLEMTSNEEEEMEMAVIYLQK;MIFCTRK 2 4.5 0.50294 0.18838 0 0 0 0 0 0 0 0 0 6.5206 0 10.177 Q7Z4V0 ZN438_HUMAN Zinc finger protein 438 ZNF438 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" KPWHRCHVCNHHFQFKQHLR;QNSVSVPPK;TKLNSGAAK;VVISTEPAPSELQPGDIPK 4 6.9 0.98065 -1.6744 8.25181 0 0 0 0 0 0 0 0 7.64191 0 9.50064 Q7Z4V5 HDGR2_HUMAN Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; positive regulation of cell growth [GO:0030307]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; skeletal muscle tissue regeneration [GO:0043403] cytoplasm [GO:0005737]; nucleus [GO:0005634] H3K27me3 modified histone binding [GO:0061628]; H3K9me3 modified histone binding [GO:0062072]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] DLFPYDK 1 1 0.90944 -0.3172 0 0 0 0 7.43221 0 0 0 7.34917 0 0 0 Q7Z4Y8 AT5L2_HUMAN "Putative ATP synthase subunit g 2, mitochondrial (ATPase subunit g 2) (ATP synthase membrane subunit g-like protein)" ATP5MGL ATP5K2 ATP5L2 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] APFVRNLVEKTPALVNAAVTYLKPR 1 25 0.66275 0.16893 0 0 0 0 0 0 0 0 4.96283 0 0 0 Q7Z553 MDGA2_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) MDGA2 MAMDC1 UNQ8188/PRO23197 Homo sapiens (Human) nervous system development [GO:0007399]; spinal cord motor neuron differentiation [GO:0021522] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] CSFLVTGK;TVFLRCVANSNPPVRYSWR;VERAWLAAGLLKVPLR 3 4.2 0.90785 -0.27691 0 0 0 0 0 0 0 0 10.1338 6.4739 7.2034 0 Q7Z569 BRAP_HUMAN BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) BRAP RNF52 Homo sapiens (Human) MAPK cascade [GO:0000165]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ANQVLLQNKLKEEER 1 2.5 0.85023 -0.079027 0 0 0 0 0 0 0 0 0 5.92353 0 0 Q7Z570 Z804A_HUMAN Zinc finger protein 804A ZNF804A C2orf10 Homo sapiens (Human) positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; regulation of neuron projection development [GO:0010975] cytoplasm [GO:0005737]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] metal ion binding [GO:0046872] ETEKYNFTK;KLCQHHHMEKTK;QSQPKSYLCHYELAEALPQGK;TLDYAEKENTIAK 4 4.5 0.97482 -3.2681 0 0 0 0 0 10.2268 0 7.52513 0 0 0 0 Q7Z572 SPT21_HUMAN Spermatogenesis-associated protein 21 SPATA21 Homo sapiens (Human) calcium ion binding [GO:0005509] QGFMKCLLEVEKMEASHR;SPFFQSGSQGNR 2 6.4 0.92141 -0.44563 0 0 0 9.49029 0 0 0 0 0 0 0 0 Q7Z589 EMSY_HUMAN BRCA2-interacting transcriptional repressor EMSY EMSY C11orf30 GL002 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] identical protein binding [GO:0042802] IDPPAVPATGQFMR;LVPLMPR;MPVVWPTLLDLSRDECK;SVSCSDEDEKPRK 4 3.9 0.87648 -0.13119 0 0 0 0 10.063 10.7677 8.4849 0 8.00377 0 0 8.53508 Q7Z591 AKNA_HUMAN Microtubule organization protein AKNA (AT-hook-containing transcription factor) AKNA KIAA1968 Homo sapiens (Human) delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] GVGSAGWPDRVTFR;LGSCLEELK;LKAAHAALEEEYLKACR;RWAWAEDKR;YLSVKSLPEAMR 5 4.2 0.97682 -4.8939 0 0 9.05338 0 10.6987 0 0 0 8.04133 9.14509 0 0 Q7Z5B4 RIC3_HUMAN Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) RIC3 UNQ720/PRO1385 Homo sapiens (Human) "positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; protein-containing complex assembly [GO:0065003]; synaptic transmission, cholinergic [GO:0007271]" endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; synapse [GO:0045202] acetylcholine receptor binding [GO:0033130]; protein folding chaperone [GO:0044183] ETEAAMEK;QETILVDYPDPK;RQEPPPTPEGK 3 8.4 0.96394 -1.1824 0 0 0 0 0 0 5.79546 7.65284 0 0 0 0 Q7Z5D8 NANGN_HUMAN NANOG neighbor homeobox (Homeobox protein C14) NANOGNB Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GQEIETILANK;SLMHTLWAK 2 10.6 0.95512 -0.86601 0 0 0 0 0 0 0 12.0092 0 0 0 0 Q7Z5G4 GOGA7_HUMAN Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa) GOLGA7 GCP16 HDCKB03P HSPC041 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein stabilization [GO:0050821]; protein targeting to membrane [GO:0006612] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; palmitoyltransferase complex [GO:0002178]; tertiary granule lumen [GO:1904724] VLKKVSK 1 5.1 0.83936 -0.038934 0 0 0 0 5.21618 0 0 0 0 2.72725 0 0 Q7Z5H3 RHG22_HUMAN Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) ARHGAP22 RHOGAP2 Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] IEEGSADLR;SIMKNWQQR;SVKRIEEGSADLR;WFVLRGDQLFYYK 4 5 0.97301 -2.8638 0 9.87171 11.0492 0 0 11.5415 0 0 0 0 0 0 Q7Z5J1 DHI1L_HUMAN Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) (Short chain dehydrogenase/reductase family 26C member 2) (Short-chain dehydrogenase/reductase 10) HSD11B1L HSD3 SCDR10 SDR26C2 Homo sapiens (Human) extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] oxidoreductase activity [GO:0016491] TLTETPLR 1 2.5 0.91352 -0.39033 0 0 0 0 0 0 0 0 0 0 13.7926 0 Q7Z5J1 DHI1L_HUMAN Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) (Short chain dehydrogenase/reductase family 26C member 2) (Short-chain dehydrogenase/reductase 10) HSD11B1L HSD3 SCDR10 SDR26C2 Homo sapiens (Human) extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] oxidoreductase activity [GO:0016491] AAGVFYPWR 1 5.9 0.91017 -0.31514 0 0 11.0878 0 0 0 0 0 0 0 0 0 Q7Z5J4 RAI1_HUMAN Retinoic acid-induced protein 1 RAI1 KIAA1820 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872] AGAHGLSKGPLEKRPYLGPALLLTPR;DQRSMILRSR;LQSCYCCDGR;LSDRPLHALK;SAFMAPVPTK;SAWPRPGEPEALPDSLQLDKGGNAK;SFLYCNQARGSPAR;VGKPSPK;VSSSPQKEGRVSQR 9 6.6 0.97652 -2.2826 12.2582 0 0 9.9545 9.29916 0 0 14.6778 11.7263 9.30385 0 12.3352 Q7Z5J8 ANKAR_HUMAN Ankyrin and armadillo repeat-containing protein ANKAR Homo sapiens (Human) membrane [GO:0016020] DSHNIFSFSSTITSDITNVSRPR;GLSAVFHTFSR;LICFLIPFLLSLKKK;LKPKIQPKDSLTLLPPVTNFMGLFK 4 5.2 0.91692 -0.39971 0 0 0 9.22574 0 3.3251 8.47873 0 0 0 0 9.09671 Q7Z5K2 WAPL_HUMAN Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) WAPL FOE KIAA0261 WAPAL Homo sapiens (Human) cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA replication [GO:0008156]; negative regulation of sister chromatid cohesion [GO:0045875]; protein localization to chromatin [GO:0071168] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP-dependent protein-DNA unloader activity [GO:0140083] CLSVISLATKCAMPSFR;FDIRVLGLGLLINLVEYSAR;TTTRFRPSNTKSK;VENFHEEHEKNSHHIHK 4 5.6 0.91029 -0.29062 0 0 11.4919 0 6.99718 0 0 0 8.3107 0 0 7.31415 Q7Z5L0 VMO1_HUMAN Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular space [GO:0005615] GAGAKLLPLLLLLR;GLGDDTALNDAR;LLPLLLLLR;VEPPQGIPGDDTALNGIR 4 21.8 0.93374 -0.5119 0 0 0 0 0 0 10.3436 0 0 0 0 0 Q7Z5L0 VMO1_HUMAN Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular space [GO:0005615] GAGAKLLPLLLLLR;GNVLGNTHVVESQSGR;GNVLGNTHVVESQSGRWGAGVEDPLG;LLPLLLLLR;VEPPQGIPGDDTALNGIR 5 50.9 0.98055 -2.0162 0 0 0 0 0 0 0 0 4.39746 10.9576 9.51686 11.6196 Q7Z5L3 C1QL2_HUMAN Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; collagen trimer [GO:0005581]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083] identical protein binding [GO:0042802] MALGLLIAVPLLLQAAPR 1 6.3 0.67537 0.16632 0 0 6.23458 0 0 0 0 0 0 0 0 0 Q7Z5L7 PODN_HUMAN Podocan PODN SLRR5A UNQ293/PRO332 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] collagen binding [GO:0005518] EKEEEEEEEEEEEETR;SAPGRSR;VLLLLLLLPPQLHLGPVLAVR 3 6.7 0.73984 0.10784 10.4671 8.34216 0 0 0 0 0 0 0 6.54285 0 5.3856 Q7Z5L9 I2BP2_HUMAN Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) IRF2BP2 Homo sapiens (Human) immature B cell differentiation [GO:0002327]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] RPASVSSSAAVEHEQR 1 2.7 0.77791 0.037641 0 0 0 0 0 0 10.2563 0 0 0 0 0 Q7Z5M5 TMC3_HUMAN Transmembrane channel-like protein 3 TMC3 Homo sapiens (Human) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] DPEHQGR;GYQAAGAELWRKFAR 2 2 0.89734 -0.24723 0 0 0 0 0 0 0 0 0 8.54365 0 0 Q7Z5M8 AB12B_HUMAN Protein ABHD12B (EC 3.-.-.-) (Abhydrolase domain-containing protein 12B) (Alpha/beta hydrolase domain-containing protein 12B) ABHD12B C14orf29 Homo sapiens (Human) monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660] endoplasmic reticulum membrane [GO:0005789] lysophospholipase activity [GO:0004622]; monoacylglycerol lipase activity [GO:0047372] SLALSSR 1 3 0.65167 0.17022 0 0 0 10.79 10.7301 0 9.04284 0 0 0 0 0 Q7Z5N4 SDK1_HUMAN Protein sidekick-1 SDK1 Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of dendritic spine development [GO:0060998]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; synapse [GO:0045202] identical protein binding [GO:0042802] DAISISRLQNPR;DLTKGVTYFFRVQAR;DNVALTPSSTSR;LAGLPGEYQQR;LVLTCLAEGSWPLEFK;VLFLPEPVVR 6 3.4 0.9643 -1.1978 0 0 12.8858 0 8.1191 0 11.187 0 12.7188 0 0 0 Q7Z5P4 DHB13_HUMAN 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.1.-) (EC 1.1.1.62) (Hepatic retinol/retinal dehydrogenase) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9) HSD17B13 SCDR9 SDR16C3 HMFN0376 UNQ497/PRO1014 Homo sapiens (Human) lipid metabolic process [GO:0006629]; positive regulation of lipid biosynthetic process [GO:0046889] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" EEIYRSLNQVK 1 3.7 0.92078 -0.44368 12.071 0 0 0 0 0 0 0 0 0 0 0 Q7Z5P9 MUC19_HUMAN Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] IFFFESSCPYTFCR;ITSGGSYTATTR;ITTATTGAFSGK;QTWCAEANR;TAKYNYDILLLEHSCLCCR;TGLSSEVTETTGLSYGVKR;TLEPGNDNTEATGSTGGIR;YGEHNVLNSR 8 1.5 0.97613 -1.4863 7.96584 8.46344 0 8.24403 8.77274 11.0896 0 5.56206 0 5.10534 11.2816 10.4391 Q7Z5Q1 CPEB2_HUMAN Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) CPEB2 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202] "GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]" AEHDPLK;LYLCVSSPTIK 2 3.1 0.9102 -0.31977 0 0 8.29572 0 0 0 0 0 0 0 0 0 Q7Z5Q5 DPOLN_HUMAN DNA polymerase nu (EC 2.7.7.7) POLN Homo sapiens (Human) DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985] nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] DDVFSTLTSQWK;FLITSNNQLREILFGK;ILTHLSGDPELLKLFQESER;IVLQFFGNDGSWK 4 6.8 0.95304 -0.67655 10.9557 0 0 0 6.79533 0 0 0 0 12.6199 0 0 Q7Z5R6 AB1IP_HUMAN Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) APBB1IP PREL1 RARP1 RIAM Homo sapiens (Human) positive regulation of cell adhesion [GO:0045785]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] APTDYCFVLKHPQIQK;ESKETNEK;TLYDNYQR 3 4.8 0.97916 -1.912 7.58489 0 0 0 0 0 0 0 0 0 9.22074 0 Q7Z5V6 SAXO4_HUMAN Stabilizer of axonemal microtubules 4 (Protein phosphatase 1 regulatory subunit 32) SAXO4 C11orf66 PPP1R32 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] phosphatase binding [GO:0019902] SIGAKEGSGFTK 1 2.8 0.91537 -0.36857 0 0 0 0 0 0 0 0 0 0 0 5.3422 Q7Z5W3 BN3D2_HUMAN RNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein) BCDIN3D Homo sapiens (Human) miRNA metabolic process [GO:0010586]; negative regulation of pre-miRNA processing [GO:2000632]; pre-miRNA processing [GO:0031054]; RNA methylation [GO:0001510]; tRNA methylation [GO:0030488] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] O-methyltransferase activity [GO:0008171]; pre-miRNA binding [GO:0070883]; RNA methyltransferase activity [GO:0008173]; small RNA 2'-O-methyltransferase activity [GO:0090486]; tRNA methyltransferase activity [GO:0008175] AVPTELDGGSVK 1 4.1 0.80342 0.013406 0 0 0 0 4.36982 0 0 0 0 0 0 0 Q7Z5Y7 KCD20_HUMAN BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) KCTD20 C6orf69 Homo sapiens (Human) positive regulation of phosphorylation [GO:0042327]; signal transduction [GO:0007165] cytoplasm [GO:0005737] identical protein binding [GO:0042802] GLKNIRIGIEGYPTCK 1 3.8 0.84995 -0.079138 0 0 0 8.13965 0 0 0 0 0 0 0 0 Q7Z602 GP141_HUMAN Probable G-protein coupled receptor 141 (G-protein coupled receptor PGR13) GPR141 PGR13 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142] PGHNTSR 1 2.3 0.91504 -0.33057 0 0 0 0 0 0 9.57425 0 9.68273 0 0 0 Q7Z628 ARHG8_HUMAN Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) NET1 ARHGEF8 Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; myoblast migration [GO:0051451]; positive regulation of apoptotic process [GO:0043065]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085] KLTAQRR;LEYLDEK;NERHSYQVYR;VLDVNNQSFR 4 6.3 0.97444 -3.5214 0 0 0 0 0 0 0 0 0 8.48361 11.8228 0 Q7Z695 ADCK2_HUMAN Uncharacterized aarF domain-containing protein kinase 2 (EC 2.7.11.-) ADCK2 AARF Homo sapiens (Human) regulation of ubiquinone biosynthetic process [GO:0010795] membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGPLGGVFLHLRLWLRAGALLVK;ATETSGPTYIK;LHVRVTPHPWTHTER 3 7.8 0.97283 -1.3701 0 0 0 8.6211 10.1211 0 9.02245 0 0 0 9.08823 0 Q7Z698 SPRE2_HUMAN "Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)" SPRED2 Homo sapiens (Human) "negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of protein deacetylation [GO:0090311]" cytosol [GO:0005829]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173] ACYHCGVMCRCCGGK;ANPTFHHWK;DLVYTKANPTFHHWK;DLVYTKANPTFHHWKVDNR;HAPVRGK;QVSFPDDDEEIVRINPR;TQPSRGK 7 15.6 0.97568 -5.1277 11.9028 9.67485 3.70951 0 11.8422 0 0 0 0 11.4099 10.7864 7.82604 Q7Z699 SPRE1_HUMAN "Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)" SPRED1 Homo sapiens (Human) "negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of MAPK cascade [GO:0043408]; regulation of protein deacetylation [GO:0090311]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]" caveola [GO:0005901]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173] CGEACGCCGGK;FNHEENVRGK;MCHRCGEACGCCGGK;QISKECGSLKSQNR;SIRHVSFQDEDEIVRINPR 5 13.1 0.97828 -1.94 0 0 0 0 0 6.02399 8.3703 7.67292 7.4025 0 2.58626 0 Q7Z6A9 BTLA_HUMAN B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272) BTLA Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response-regulating cell surface receptor signaling pathway [GO:0002768] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] LNGTTCVKLEDR;SASERPSKDEMASRPWLLYR 2 11.1 0.98022 -1.6429 0 0 0 6.90809 9.202 0 0 0 0 0 0 0 Q7Z6B0 CCD91_HUMAN Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) CCDC91 GGABP HSD8 Homo sapiens (Human) Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802] AGHEALSIIVDEYKHQR;EQEAISFQDR;ISQETVKAAIIEEQK 3 10.4 0.95458 -0.96063 0 0 0 0 0 0 11.9101 0 7.93091 0 0 9.26618 Q7Z6B7 SRGP1_HUMAN SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] ALHIRKLLLTLPR;ASEDWWEGR;CLEQQTEMR;EAEKQEEKQIGR;FMQISEDSTR;LYFRGLENPLFPKER;QAKYSENK;VLNELYTVMK;YYIHDLSDLIDCCDLGYHASLNR 9 10 0.97241 -2.7514 10.4549 0 8.73403 11.038 3.52457 0 0 10.3556 9.74656 11.0701 3.89995 9.19628 Q7Z6E9 RBBP6_HUMAN E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) RBBP6 P2PR PACT RBQ1 My038 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EHQETKPVK;GVDKDFESSSMKISK;ISLSAPAKKIK;LESTSSK;LSARDGHNQK;MSCVHYK;NVPQGETER;QIMGREK;TDYDTREYSSSKR;YREVPPPYDMK 10 5.5 0.97454 -3.4965 0 11.4774 0 9.90165 10.9292 0 0 0 0 9.17737 8.77261 11.3077 Q7Z6G3 NECA2_HUMAN N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) NECAB2 EFCBP2 Homo sapiens (Human) negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of protein localization to membrane [GO:1905477]; regulation of amyloid precursor protein biosynthetic process [GO:0042984] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] A2A adenosine receptor binding [GO:0031687]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; type 5 metabotropic glutamate receptor binding [GO:0031802] GGTAVILDIFRRADK 1 3.9 0.7894 0.017005 0 0 0 0 0 0 0 0 11.2079 0 0 0 Q7Z6G8 ANS1B_HUMAN Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) ANKS1B Homo sapiens (Human) ephrin receptor signaling pathway [GO:0048013] Cajal body [GO:0015030]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ephrin receptor binding [GO:0046875] DQELLEAARTGNVALVEK;GQDEVSLANSPLPFKQSPIENNSEPLVKK 2 3.8 0.92126 -0.44138 0 0 0 10.1553 10.1088 9.47968 0 0 0 0 0 0 Q7Z6G8 ANS1B_HUMAN Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) ANKS1B Homo sapiens (Human) ephrin receptor signaling pathway [GO:0048013] Cajal body [GO:0015030]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ephrin receptor binding [GO:0046875] GQDEVSLANSPLPFKQSPIENNSEPLVKK;LAQESYPK 2 4.8 0.97806 -1.505 0 0 6.05216 9.62629 0 0 0 0 0 8.55516 0 0 Q7Z6I6 RHG30_HUMAN Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) ARHGAP30 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] GTPase activator activity [GO:0005096] AYFRELPDPLLTYRLYDK;DRQRTEAQGVR;FAEAVGVQLEPER 3 3.8 0.96543 -1.2429 0 0 11.6781 9.40009 0 0 0 0 0 5.57362 0 0 Q7Z6J2 GRASP_HUMAN Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) TAMALIN GRASP Homo sapiens (Human) regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] glutamatergic synapse [GO:0098978]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267] ALAVSGGTLPR 1 2.8 0.89306 -0.22531 0 0 0 0 0 0 12.7749 0 0 0 0 0 Q7Z6J4 FGD2_HUMAN "FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)" FGD2 ZFYVE4 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] APQWVRDK;GRWVKAMER;IDVAGMK;LSSEAWRK;RLDDWTANPR;RNDPMER;YLFLFNNMLLYCVPR 7 9.8 0.9751 -1.4425 0 10.1672 10.9852 0 0 10.4168 10.4308 0 7.82934 10.2092 0 6.30102 Q7Z6J6 FRMD5_HUMAN FERM domain-containing protein 5 FRMD5 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901] AGMVPSR;QTPEFEQFHYQYFCPLR;SLEREYSCTVR 3 6.1 0.97942 -1.5404 9.10808 0 0 0 0 0 0 0 0 0 0 12.9485 Q7Z6J9 SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) TSEN54 SEN54 Homo sapiens (Human) "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] QVQRSQRR 1 1.5 0.96381 -1.1925 0 0 0 0 0 0 11.2018 0 0 0 0 0 Q7Z6K1 THAP5_HUMAN THAP domain-containing protein 5 THAP5 Homo sapiens (Human) negative regulation of cell cycle [GO:0045786]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protease binding [GO:0002020] ITLLELKEQQTLGRLK;LSFYPFPLHDKERLEK;NLEDEKEVCPK 3 10.9 0.92919 -0.48487 0 0 0 0 0 0 0 0 0 8.1354 11.6097 0 Q7Z6K3 PTAR1_HUMAN Protein prenyltransferase alpha subunit repeat-containing protein 1 PTAR1 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] protein prenyltransferase activity [GO:0008318] FLLPYVHNKLLLYR;LGVESWCVK 2 5.7 0.96455 -1.1518 0 0 0 0 0 0 0 11.06 0 6.23494 8.0207 0 Q7Z6K5 ARPIN_HUMAN Arpin (Arp2/3 inhibition protein) ARPIN C15orf38 Homo sapiens (Human) directional locomotion [GO:0033058]; negative regulation of actin nucleation [GO:0051126]; negative regulation of cell migration [GO:0030336]; negative regulation of lamellipodium morphogenesis [GO:2000393] lamellipodium [GO:0030027] GDTDRLTPEALK;NINIGDLNIKVPNLSQFV 2 7.6 0.98041 -2.0172 0 0 0 0 9.37186 0 9.08042 0 0 0 0 0 Q7Z6L0 PRRT2_HUMAN Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) PRRT2 Homo sapiens (Human) negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629] axon terminus [GO:0043679]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982] syntaxin-1 binding [GO:0017075] GVEESPK 1 2.1 0.60981 0.17565 0 0 0 0 0 0 0 0 0 0 0 10.041 Q7Z6L1 TCPR1_HUMAN Tectonin beta-propeller repeat-containing protein 1 TECPR1 KIAA1358 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; regulation of autophagosome maturation [GO:1901096] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] phosphatidylinositol-3-phosphate binding [GO:0032266] EGINRSNPK;MPNSVLWAVDLFGR;VYTLSTAGQYWEMCK 3 3.3 0.96721 -1.3125 0 0 0 0 6.71685 7.37443 0 0 0 11.5564 12.7134 0 Q7Z6M1 RABEK_HUMAN Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) RABEPK RAB9P40 Homo sapiens (Human) receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904] cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] LFIHGGLAGDR 1 3 0.89789 -0.23329 7.68916 0 0 0 0 0 0 0 0 0 0 0 Q7Z6M2 FBX33_HUMAN F-box only protein 33 FBXO33 FBX33 Homo sapiens (Human) positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567] AGAARVARWR;LSLLVHNVSVMHK 2 4.1 0.97379 -1.3975 7.69404 0 0 0 0 10.2458 0 0 0 0 0 0 Q7Z6M3 MILR1_HUMAN Allergin-1 (Allergy inhibitory receptor 1) (Mast cell antigen 32) (MCA-32) (Mast cell immunoglobulin-like receptor 1) MILR1 C17orf60 MCA32 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; mast cell degranulation [GO:0043303]; negative regulation of mast cell activation [GO:0033004] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AQVTSCSK;KNPGEEEEYRCEAK;LLLPGLLLLLVVIILILAFWVLPKYK;SLQITYSLFR;WSHLNRLLFWSIFSSVTCR 5 22.4 0.95244 -0.75012 10.5567 9.88091 0 0 0 0 0 0 0 10.4177 0 0 Q7Z6M4 MTEF4_HUMAN "Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]" MTERF4 MTERFD2 HSPC096 Homo sapiens (Human) camera-type eye development [GO:0043010]; heart development [GO:0007507]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; protein targeting to mitochondrion [GO:0006626]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364] cytosol [GO:0005829]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] double-stranded DNA binding [GO:0003690]; rRNA binding [GO:0019843] EEEESESSTSDDK;LLKEKCLFTVQQVTK 2 7.3 0.41328 0.20118 0 0 11.0406 0 0 0 0 0 0 0 0 3.80085 Q7Z6P3 RAB44_HUMAN Ras-related protein Rab-44 RAB44 Homo sapiens (Human) histamine secretion by mast cell [GO:0002553]; histamine secretion mediated by IgE immunoglobulin [GO:0097279]; vesicle-mediated transport [GO:0016192] azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVQQLYEEMEQQIR;EVQRLAEGQR;MQEEGLK 3 3 0.98017 -1.7185 12.3745 8.30474 0 0 0 0 0 0 0 0 10.8979 0 Q7Z6R9 AP2D_HUMAN Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) TFAP2D TFAP2BL1 Homo sapiens (Human) inferior colliculus development [GO:0061379]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" NGGRCLREK 1 2 0.97424 -1.4211 0 0 0 0 0 9.13584 0 0 0 0 0 0 Q7Z6W1 TMCO2_HUMAN Transmembrane and coiled-coil domain-containing protein 2 TMCO2 Homo sapiens (Human) membrane [GO:0016020]; nucleus [GO:0005634] ISFLILLGIGIYALWKRSIQSIQK;TLLFVITLYK 2 18.7 0.84789 -0.062198 11.5292 0 0 0 0 0 0 0 0 0 5.39053 0 Q7Z6Z7 HUWE1_HUMAN "E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] DKEGDRASEEGK;DLSMSEEDQMMR;FDMAENVVIVASQK;HVLDTLIQLAK;HVMDGSLPTSLK;KSSKSCGSSSHENRPLDLLHK;LLEEICNLGR;LLEEICNLGRDPK;LLGPSAAADILQLSSSLPLQSR;LTQGIGR;QLAEEETK;QLMEIKAASLR;QPNPPLILQRLLGPSAAADILQLSSSLPLQSR;RPVMLTLLRVPR;SPAFTSR;TSTQKFFLR;YICQKPSIQK;YTVQFTTMVQVNEETGNR 18 4.8 0 2.6571 7.85037 0 0 11.4662 2.79624 10.7492 12.6066 8.95997 11.0295 9.23795 10.2543 11.6244 Q7Z736 PKHH3_HUMAN Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) PLEKHH3 Homo sapiens (Human) cytoskeleton [GO:0005856]; extracellular space [GO:0005615] EVIASKAPLETPTQLLLR 1 2.3 0.82544 -0.020587 0 0 0 0 0 0 0 0 0 0 8.15942 0 Q7Z739 YTHD3_HUMAN YTH domain-containing family protein 3 (DF3) YTHDF3 Homo sapiens (Human) mRNA destabilization [GO:0061157]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of mRNA stability [GO:0043488]; regulation of trophoblast cell migration [GO:1901163]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] GQGNKVSVQNGSIHQK;KPAKPQPKLKPKGNVGIGGSAVPPPPIK;SIKYSIWCSTEHGNK;VPGISSIEQGMTGLK 4 12.6 0.98037 -1.7139 0 0 7.51191 9.37465 6.14944 0 0 9.09471 6.13754 9.52838 7.26228 6.30956 Q7Z745 MRO2B_HUMAN Maestro heat-like repeat-containing protein family member 2B (HEAT repeat-containing protein 7B2) (Sperm PKA-interacting factor) (SPIF) MROH2B HEATR7B2 Homo sapiens (Human) cell differentiation [GO:0030154]; protein kinase A signaling [GO:0010737]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] ALKKILELLTDR;EIDFHVTQSLK;ILIMAEEK;ILPEIIHPKLVDLWKTR;LAEDERMK;LVDLWKTR;RLLPLPPLENLK;TFFEDEQDDVR 8 5 0.97596 -1.4846 0 0 0 6.18632 5.64175 0 6.19653 6.38488 0 8.16551 4.20688 0 Q7Z794 K2C1B_HUMAN "Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)" KRT77 KRT1B Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] DVDAAYVSK;FASFIDK;FASFIDKVR;FLEQQNQVLQTK;LQAEISNVK;LQAEISNVKKQIEQMQSLISDAEER;QLLEGEESR;TQYELIAQRSKDEAEALYQTK;YQELQITAGR 9 16.4 0.94205 -0.59678 0 0 0 7.62637 9.50597 0 11.3932 11.7545 0 12.1741 11.6421 9.73166 Q7Z7A1 CNTRL_HUMAN Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) aorta development [GO:0035904]; cell division [GO:0051301]; coronary vasculature development [GO:0060976]; kidney development [GO:0001822]; ventricular septum development [GO:0003281] centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; meiotic spindle pole [GO:0090619]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471] AAQAARDLTR;AEELQEAERFSRK;AEQQILRATEEFKQLEEAIQLK;ALEARMNFDKR;EIERMTAESRALQSCVECLSK;FEDCQKEEETK;ISAAQTR;KAAQAAR;LNFSQVHIMDEHWR;LNFSQVHIMDEHWRGEALREK;LNLRDAEANQLKEELEK;SLKHHEDIVDEIECIEKTLLK;TIELTRACQK 13 7.1 0.97711 -5.7984 7.68201 12.6684 9.45845 0 8.87418 5.16551 12.0882 6.77663 2.36135 8.3978 11.4205 11.3183 Q7Z7A3 CTU1_HUMAN Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1) CTU1 ATPBD3 NCS6 Homo sapiens (Human) protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; cytosolic tRNA wobble base thiouridylase complex [GO:0002144] nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] EVVLYAHFR 1 2.6 0.92942 -0.46819 11.9861 0 0 0 0 0 0 0 0 0 0 0 Q7Z7A4 PXK_HUMAN "PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)" PXK Homo sapiens (Human) inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091] FFRSEPKWEVVEPLK;GTLKDLIYKAKPK;NGMPTISR 3 8.2 0.9563 -0.85073 0 0 0 0 0 8.85695 0 0 0 0 8.85954 0 Q7Z7B0 FLIP1_HUMAN Filamin-A-interacting protein 1 (FILIP) FILIP1 KIAA1275 Homo sapiens (Human) modification of postsynaptic structure [GO:0099010]; protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] ELECSESRLEK;KYNSNANIITTEDNK;LLKLEVDFEHK;TILKVTPEKQTVPTPVR;VQDLTQKLR 5 5.2 0.97844 -1.9232 0 0 6.14115 5.33842 9.0471 7.21412 0 0 0 0 8.72744 0 Q7Z7B7 DB132_HUMAN "Beta-defensin 132 (Beta-defensin 32) (BD-32) (DEFB-32) (Defensin HEL-75) (Defensin, beta 132)" DEFB132 DEFB32 UNQ827/PRO1754 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640] extracellular space [GO:0005615]; sperm head [GO:0061827] NTQRKDK 1 7.4 0.81131 -0.014248 0 0 0 8.95294 0 0 0 0 0 0 0 0 Q7Z7B8 DB128_HUMAN "Beta-defensin 128 (Beta-defensin 28) (DEFB-28) (Defensin, beta 128)" DEFB128 DEFB28 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640] extracellular region [GO:0005576] LFLVLIILLFEVLTDGAR;VTGYCRKK 2 28 0.9616 -1.071 0 0 0 0 6.56394 0 0 0 0 0 0 0 Q7Z7C8 TAF8_HUMAN Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) TAF8 TAFII43 TBN Homo sapiens (Human) cell differentiation [GO:0030154]; DNA-templated transcription open complex formation [GO:0001112]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of fat cell differentiation [GO:0045598]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251] FSSLSLLSSWNYR;RSQRMVITAPPVTNQPVTPK 2 9.8 0.9731 -1.3733 0 0 0 0 0 12.6254 0 0 0 13.5786 13.0569 6.38377 Q7Z7D3 VTCN1_HUMAN V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x) VTCN1 B7H4 UNQ659/PRO1291 Homo sapiens (Human) adaptive immune response [GO:0002250]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; regulation of cytokine production [GO:0001817]; response to protozoan [GO:0001562]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] EGKDELSEQDEMFR 1 5 0.92144 -0.44571 0 0 0 0 0 5.14902 0 0 0 0 0 0 Q7Z7E8 UB2Q1_HUMAN Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) UBE2Q1 NICE5 UBE2Q PRO3094 Homo sapiens (Human) embryo implantation [GO:0007566]; fertilization [GO:0009566]; mating behavior [GO:0007617]; prolactin secretion [GO:0070459]; protein polyubiquitination [GO:0000209]; reproductive system development [GO:0061458]; suckling behavior [GO:0001967] cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] ELRDIYRSQSFK;LVDIKKGNTLLLQHLK;SEDDGIGKENLAILEKIK;VQFGANK 4 12.6 0.93659 -0.54478 5.77908 0 0 8.15183 0 0 4.03439 0 5.88448 0 8.52485 0 Q7Z7F7 RM55_HUMAN "Large ribosomal subunit protein mL55 (39S ribosomal protein L55, mitochondrial) (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m)" MRPL55 UNQ5835/PRO19675 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] QAYARLYPVLLVK 1 10.2 0.88916 -0.18686 0 0 6.97991 0 0 0 0 0 0 0 0 0 Q7Z7G0 TARSH_HUMAN Target of Nesh-SH3 (Tarsh) (ABI gene family member 3-binding protein) (Nesh-binding protein) (NeshBP) ABI3BP NESHBP TARSH Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] LSSLGCLLLCGSITLALGNAQK 1 2.1 0.67538 0.16642 0 0 0 0 0 0 0 0 0 0 10.2797 0 Q7Z7G1 CLNK_HUMAN Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) CLNK MIST Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of natural killer cell cytokine production [GO:0002729] cytoplasm [GO:0005737]; mast cell granule [GO:0042629]; protein-containing complex [GO:0032991] protein-containing complex binding [GO:0044877] DVRSQNIK;EGSNDLKFQNFSLPK 2 5.4 0.95035 -0.66787 0 0 0 0 0 0 0 0 0 8.74147 0 0 Q7Z7G8 VP13B_HUMAN Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) acrosome assembly [GO:0001675]; adipose tissue development [GO:0060612]; central nervous system development [GO:0007417]; dentate gyrus development [GO:0021542]; Golgi organization [GO:0007030]; Golgi reassembly [GO:0090168]; head morphogenesis [GO:0060323]; lipid transport [GO:0006869]; maintenance of lens transparency [GO:0036438]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; slow endocytic recycling [GO:0032458]; social behavior [GO:0035176]; vesicle-mediated transport [GO:0016192] acrosomal membrane [GO:0002080]; cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] phosphatidylinositol-3-phosphate binding [GO:0032266] GTLTSITNLATSLAR;IISAGHK;ILIGPCCATANLEAK;ILKMIVCALEHEYEPYSR;LCITLNEGK;LLKLPTCWTK;LSLDEEHYNR;NMDRLSLDEEHYNR;RTSRHMQQQPVVAVPLVMPVCR;SIGNGVADFFR;VDIFDGGMAETSSR 11 3.4 0.9749 -3.278 10.989 0 4.96786 7.69565 10.4513 8.08942 5.83097 12.4953 0 0 0 10.5386 Q7Z7H5 TMED4_HUMAN Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) TMED4 ERS25 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794] ARQLLDQVEQIQKEQDYQR;LRVHLDIQVGEHANNYPEIAAK 2 18.1 0.87441 -0.10643 7.56834 9.98868 0 0 0 0 0 0 0 0 0 0 Q7Z7K0 COXM1_HUMAN COX assembly mitochondrial protein homolog (Cmc1p) CMC1 C3orf68 Homo sapiens (Human) mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] metal ion binding [GO:0046872] DVLIPKIMR;ERCSEQVQDFTK 2 19.8 0.96506 -1.1196 0 0 0 11.3819 0 0 2.55988 0 0 0 0 0 Q7Z7K2 ZN467_HUMAN Zinc finger protein 467 ZNF467 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSRKSHLGR 1 1.5 0.97618 -1.4752 0 0 0 0 0 0 0 0 0 0 8.91436 0 Q7Z7K6 CENPV_HUMAN Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6) CENPV PRR6 Homo sapiens (Human) ameboidal-type cell migration [GO:0001667]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044] cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233] carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] HFIVPASRFKLLK;SRSSAAAK 2 7.6 0.97993 -1.8743 0 11.0494 0 0 0 0 0 0 0 8.97628 0 0 Q7Z7L7 ZER1_HUMAN Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein) ZER1 C9orf60 ZYG ZYG11BL Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] Cul2-RING ubiquitin ligase complex [GO:0031462] DIIKMATARQETK;HLDISRDR;VIEHCSNFK 3 3.9 0.98015 -2.0416 3.35896 0 0 0 0 0 0 0 0 4.13595 9.175 8.92825 Q7Z7L8 CK096_HUMAN Uncharacterized protein C11orf96 (Protein Ag2 homolog) C11orf96 AG2 Homo sapiens (Human) FKWHSLSSELRAVWAAAGYISR;GAGEGDLRPRGQPGWCR;LGARRNSAPR 3 11.3 0.97691 -1.4966 0 7.47054 0 7.88582 0 0 0 8.07526 0 0 0 0 Q7Z7L9 ZSCA2_HUMAN Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) ZSCAN2 ZFP29 ZNF854 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ECGESFSYNSNLIR;MAADIPR 2 3.4 0.90312 -0.26451 0 0 10.5024 0 0 0 0 0 0 9.86848 0 0 Q7Z7M0 MEGF8_HUMAN Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) MEGF8 C19orf49 EGFL4 KIAA0817 Homo sapiens (Human) aorta development [GO:0035904]; BMP signaling pathway [GO:0030509]; cell migration involved in gastrulation [GO:0042074]; coronary vasculature development [GO:0060976]; craniofacial suture morphogenesis [GO:0097094]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; epiboly involved in gastrulation with mouth forming second [GO:0055113]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; limb morphogenesis [GO:0035108]; negative regulation of smoothened signaling pathway [GO:0045879]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of axon extension involved in axon guidance [GO:0048842]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; smoothened signaling pathway [GO:0007224] extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] calcium ion binding [GO:0005509] CSRDCGCSFHSHCR;DCYKYQCAKCR;KRGPGFCDECQDWTWGEHCER;WCTNCPEGACIGR 4 2.1 0.072934 0.41641 0 0 0 0 0 0 0 7.50565 0 5.06622 4.82924 6.42916 Q7Z7M9 GALT5_HUMAN Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) GALNT5 Homo sapiens (Human) glycosaminoglycan biosynthetic process [GO:0006024]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EILLVDDFSTKDYLK;GLKWLHK;QRSQAVANER;QSINETPLGSLSK;VEVDLDQTQRERK 5 6.2 0.97502 -4.1254 0 12.4852 13.0402 0 0 9.03549 0 12.8662 11.5145 10.6955 0 11.6529 Q86SE5 RALYL_HUMAN RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3) RALYL HNRPCL3 Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723] AVIPLKRPR;LFDYHGR 2 5.5 0.95542 -0.94398 0 0 0 0 0 0 0 0 0 3.25589 0 0 Q86SE9 PCGF5_HUMAN Polycomb group RING finger protein 5 (RING finger protein 159) PCGF5 RNF159 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; random inactivation of X chromosome [GO:0060816]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805] histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872] VTVGTIKKFLSLK 1 5.1 0.61067 0.17497 5.06117 0 0 0 0 0 0 0 0 0 0 0 Q86SF2 GALT7_HUMAN N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) GALNT7 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EPEPPGVVGGPGEK;LWNGLVK;VVEVWWDEYK 3 4.7 0.97562 -1.4331 0 0 0 0 0 0 0 9.57641 0 0 0 9.77824 Q86SG2 ANR23_HUMAN Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3) ANKRD23 DARP Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of sarcomere organization [GO:0060297]; response to muscle stretch [GO:0035994] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; I band [GO:0031674]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] titin binding [GO:0031432]; transcription cis-regulatory region binding [GO:0000976] IGSTPLHVAVR;MDFISIQQLVSGER 2 9.5 0.96534 -1.1207 0 0 0 0 0 0 0 1.69024 0 9.12655 0 9.99774 Q86SG4 DPCA2_HUMAN Putative Dresden prostate carcinoma protein 2 (D-PCa-2) (High mobility group nucleosome-binding domain-containing protein 2 pseudogene 46) HMGN2P46 C15orf21 Homo sapiens (Human) chromatin organization [GO:0006325] nucleus [GO:0005634] chromatin binding [GO:0003682] APLPSAYVPPLSLPPCPRER;GITLQKMEMPKQTR 2 22.7 0.97344 -2.9059 0 13.318 8.29939 0 0 0 0 0 0 0 0 0 Q86SG6 NEK8_HUMAN Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) NEK8 JCK NEK12A Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of hippo signaling [GO:0035330] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SVTDEPVPP;VVGRGAFGIVHLCLRK 2 3.6 0.91573 -0.39533 0 0 0 0 4.04282 0 0 0 0 10.5536 0 0 Q86SH2 ZAR1_HUMAN Zygote arrest protein 1 ZAR1 Homo sapiens (Human) mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; oocyte maturation [GO:0001556]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232] metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA sequestering activity [GO:0140610] LSCDSTFSFKYII;SALRSPGQPPSAGRAR 2 6.8 0.898 -0.25393 0 0 0 8.57558 0 0 0 0 0 0 6.23262 0 Q86SJ6 DSG4_HUMAN Desmoglein-4 (Cadherin family member 13) DSG4 CDHF13 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; cell-cell adhesion [GO:0098609]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte differentiation [GO:0030216] cornified envelope [GO:0001533]; desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] VLDVNDNFPTLEK 1 1.2 0.80436 0.013589 0 0 0 0 0 0 0 0 0 0 0 10.2869 Q86SM8 MRGRE_HUMAN Mas-related G-protein coupled receptor member E (G-protein coupled receptor 167) MRGPRE GPR167 MRGE Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] GLVDIAA;HLCRTLWLVAAVLLALLCCTMCGASLMLLLRVER 2 13.1 0.95525 -0.86312 0 0 0 9.97355 0 0 11.1867 10.652 10.5169 0 0 0 Q86SP6 GP149_HUMAN Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10) GPR149 PGR10 Homo sapiens (Human) antral ovarian follicle growth [GO:0001547]; negative regulation of ovulation [GO:0060280]; neuropeptide signaling pathway [GO:0007218]; preantral ovarian follicle growth [GO:0001546] neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923] CTNTDITEAK;RLSHEESQKPDLSDWEWCR 2 4 0.78329 0.023306 0 0 0 0 7.35667 0 0 0 0 0 13.2459 0 Q86SQ0 PHLB2_HUMAN Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) PHLDB2 LL5B Homo sapiens (Human) "cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]" anchoring junction [GO:0070161]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; podosome [GO:0002102] cadherin binding [GO:0045296] ELDMECALLDGEQK;LERLQELYSEQK;LLESREREMEAK;NIVSRKEK 4 3.7 0.98157 -1.7691 0 0 0 12.0406 12.1098 0 0 0 0 5.13492 11.3073 0 Q86SQ3 AGRE4_HUMAN Putative adhesion G protein-coupled receptor E4P (EGF-like module receptor 4) (EGF-like module-containing mucin-like hormone receptor-like 4) (G-protein coupled receptor 127) (G-protein coupled receptor PGR16) ADGRE4P EMR4 EMR4P GPR127 PGR16 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] NGSREDFAR;TYFHDSSEKCEDINECETGLAK 2 13.4 0.98117 -1.5755 0 0 0 6.67779 0 9.37597 0 0 0 0 0 0 Q86SQ4 AGRG6_HUMAN Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)] ADGRG6 DREG GPR126 VIGR Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula formation [GO:0060347]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; nervous system development [GO:0007399]; Schwann cell differentiation [GO:0014037] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; laminin binding [GO:0043236] KGFNASYIR;SLEDEPR;SSDNLGKSLSSSSIGSNSTYLTSKSK;TGLFQDVGPQR 4 4.3 0.95901 -1.0368 0 6.42844 0 0 0 9.13538 0 0 0 0 0 7.39034 Q86SQ6 AGRA1_HUMAN Adhesion G protein-coupled receptor A1 (G-protein coupled receptor 123) ADGRA1 GPR123 KIAA1828 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930] FEEVTFPPLTAAER;FYLVSGGVPFIICGVTAATNIR;SVASGGK 3 3.4 0.84539 -0.056269 0 0 0 0 0 0 11.4689 11.7006 0 0 0 9.33916 Q86SQ7 SDCG8_HUMAN Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) SDCCAG8 CCCAP NPHP10 HSPC085 Homo sapiens (Human) cell projection organization [GO:0030030]; centrosome cycle [GO:0007098]; establishment of cell polarity [GO:0030010]; microtubule organizing center organization [GO:0031023]; neuron migration [GO:0001764]; regulation of cilium assembly [GO:1902017]; tube formation [GO:0035148] cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; photoreceptor cell cilium [GO:0097733] AIEKDMMKK;EITKEREYMGSK;VCGEMRYQLNKTNMEK 3 5.2 0.97643 -2.2709 0 12.1476 0 0 0 0 7.70141 0 0 0 0 0 Q86SR1 GLT10_HUMAN Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) GALNT10 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] DKTLYHPVSGSCMDCSESDHR;KPLEDYMALFPSVRILRTK 2 6.6 0.9359 -0.52006 0 0 0 0 7.21839 0 0 0 0 0 6.00045 0 Q86SS6 SYT9_HUMAN Synaptotagmin-9 (Synaptotagmin IX) (SytIX) SYT9 Homo sapiens (Human) calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; positive regulation of vesicle fusion [GO:0031340]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] "calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]" IYLLPDRK;LCWVPWRER;PGARDALCHQALQLLAELCAR;SLDNDDGR 4 9.4 0.97422 -2.41 0 12.4516 0 7.6367 9.43971 12.5695 0 0 0 13.6332 0 14.0858 Q86SU0 ILDR1_HUMAN Immunoglobulin-like domain-containing receptor 1 (Angulin-2) ILDR1 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; peptide hormone secretion [GO:0030072]; positive regulation of peptide hormone secretion [GO:0090277]; protein localization to tricellular tight junction [GO:0061833]; regulation of RNA splicing [GO:0043484]; response to fatty acid [GO:0070542]; tricellular tight junction assembly [GO:1904274] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689] high-density lipoprotein particle receptor activity [GO:0070506]; identical protein binding [GO:0042802] CPCCPAHCCCPEEALAR 1 3.1 0.67165 0.16766 0 4.43889 0 0 0 6.69641 0 4.50837 0 0 6.8315 0 Q86SX3 TEDC1_HUMAN Tubulin epsilon and delta complex protein 1 TEDC1 C14orf80 Homo sapiens (Human) positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737] DGGPAQPHGPHR;RAAWEAK;TLERENQR 3 5.5 0.97876 -2.0529 0 9.46017 0 0 0 0 0 0 0 0 0 9.07521 Q86SX6 GLRX5_HUMAN "Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)" GLRX5 C14orf87 Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035] dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" WGRGAGGGGLWGPGVR 1 10.2 0.91657 -0.42544 0 0 0 0 9.08462 0 0 0 0 0 0 0 Q86T03 PP4P1_HUMAN "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)" PIP4P1 C14orf9 TMEM55B Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; lysosome localization [GO:0032418]; phosphatidylinositol dephosphorylation [GO:0046856]; phospholipid metabolic process [GO:0006644]; positive regulation of TORC1 signaling [GO:1904263]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to sterol depletion [GO:0006991] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" IACPRPYCK 1 3.2 0.91604 -0.37509 11.7146 0 0 0 0 0 0 0 0 0 0 0 Q86T03 PP4P1_HUMAN "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)" PIP4P1 C14orf9 TMEM55B Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; lysosome localization [GO:0032418]; phosphatidylinositol dephosphorylation [GO:0046856]; phospholipid metabolic process [GO:0006644]; positive regulation of TORC1 signaling [GO:1904263]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to sterol depletion [GO:0006991] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" LPSLRNR 1 4.7 0.98052 -1.6279 0 0 0 0 12.0095 0 0 0 0 0 0 0 Q86T24 KAISO_HUMAN Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) ZBTB33 KAISO ZNF348 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" QYAYLSDR 1 1.2 0.93689 -0.55703 0 0 0 0 0 0 0 11.0323 0 0 0 0 Q86T29 ZN605_HUMAN Zinc finger protein 605 ZNF605 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFAWKPQLLRHQR;AFSRKSLLILHQR;HQRIHTGDKYYGCNECGTTFNR;KAFAWKPQLLR;LLFCIKPGR;SLKCPFDLLIPKNNCER;YCDCSTCR 7 12.9 0.97597 -1.4701 0 3.22042 0 4.71337 8.26688 9.18876 0 0 11.5095 0 0 6.59331 Q86T65 DAAM2_HUMAN Disheveled-associated activator of morphogenesis 2 DAAM2 KIAA0381 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; determination of left/right symmetry [GO:0007368]; dorsal spinal cord development [GO:0021516]; negative regulation of oligodendrocyte differentiation [GO:0048715]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of filopodium assembly [GO:0051489]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; Wnt signaling pathway [GO:0016055] extracellular exosome [GO:0070062] actin binding [GO:0003779]; small GTPase binding [GO:0031267] AVEVLEYQR;FIPEKSDIDLLEEHKHEIER;LARESQELR;SDIDLLEEHK;SGEVFDK;TLEKEEMMR 6 5.1 0.97643 -5.0011 0 0 0 13.764 7.14802 12.9858 14.9948 14.8993 14.6527 13.6649 13.4629 13.5957 Q86T82 UBP37_HUMAN Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) USP37 KIAA1594 Homo sapiens (Human) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508]; regulation of DNA replication [GO:0006275]; regulation of protein stability [GO:0031647] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; protein kinase binding [GO:0019901] KQAWFTYNDLEVSK;SLGFLPQPVPLSVKKLR;YLTSSREK 3 4 0.95833 -1.0026 0 0 6.43401 9.52007 0 0 0 0 0 0 0 0 Q86T90 K1328_HUMAN Protein hinderin KIAA1328 Homo sapiens (Human) GTGDSVDEQNSCRGEIK;TVGFHSHMKDDAQWSCQKK;VHDSHPTNMTPQHPK 3 8.8 0.97373 -1.3993 0 0 0 11.4846 0 0 0 11.8558 0 8.5982 0 0 Q86T96 RN180_HUMAN E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180) RNF180 Homo sapiens (Human) adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein polyubiquitination [GO:0000209]; serotonin metabolic process [GO:0042428] endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630] EYLKIKQSFQK;TLAKDNPSSTPCPLCR;VQSGCDKEALLTGGGSENRNHR 3 8.3 0.97313 -2.9496 0 0 0 0 0 0 15.7512 0 0 0 0 0 Q86TA1 MOB3B_HUMAN MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) (MOB kinase activator-like 2B) MOB3B C9orf35 MOBKL2B Homo sapiens (Human) regulation of hippo signaling [GO:0035330]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] AQASLNSGVDLK;KILCRLFR;YEYRWQDDLKYK 3 14.8 0.98075 -1.782 0 0 0 6.52834 0 10.6773 0 0 0 0 0 0 Q86TB3 ALPK2_HUMAN Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) ALPK2 HAK Homo sapiens (Human) cardiac muscle cell development [GO:0055013]; epicardium morphogenesis [GO:1905223]; establishment of cell polarity [GO:0030010]; heart morphogenesis [GO:0003007]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; regulation of apoptotic process [GO:0042981]; regulation of gene expression [GO:0010468] basolateral plasma membrane [GO:0016323] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ILSRVAALRLK;LAAQECYVQNTARYYAK;SIAQVQR;TLAFISGER;VQTNSMTIK 5 2.4 0.97471 -1.4285 0 0 0 10.4493 9.78134 3.86374 0 0 0 9.83848 0 0 Q86TB9 PATL1_HUMAN Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) PATL1 OK/KNS-cl.5 Homo sapiens (Human) deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605] poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] LNLLETKLQLVQGIR 1 1.9 0.91993 -0.43847 0 0 0 4.97604 0 0 0 0 0 0 0 0 Q86TC9 MYPN_HUMAN Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; sarcomere organization [GO:0045214] axon [GO:0030424]; cytosol [GO:0005829]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; cytoskeletal protein binding [GO:0008092]; muscle alpha-actinin binding [GO:0051371]; SH3 domain binding [GO:0017124] NTKSPQPVNDDNIRETK;QTRPDSFQERFNGQATK 2 2.6 0.98164 -1.7703 4.52544 0 0 0 0 0 0 12.6442 12.4804 0 0 0 Q86TD4 SRCA_HUMAN Sarcalumenin SRL Homo sapiens (Human) store-operated calcium entry [GO:0002115] sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] GTP binding [GO:0005525] SFSPLEK 1 1.5 0.90956 -0.3178 0 0 0 8.84342 0 0 0 0 0 0 0 0 Q86TE4 LUZP2_HUMAN Leucine zipper protein 2 LUZP2 UNQ2566/PRO6246 Homo sapiens (Human) extracellular region [GO:0005576] DLQNENKSLKNK;ETSEKAEK;LLELGQKQR;MLLPPRNIASKLPDAAAK;SLQEALQNQLK 5 16.8 0.98038 -1.5578 0 0 0 0 0 0 0 0 4.70493 0 0 11.8562 Q86TE4 LUZP2_HUMAN Leucine zipper protein 2 LUZP2 UNQ2566/PRO6246 Homo sapiens (Human) extracellular region [GO:0005576] DLQNENKSLKNK;ETSEKAEK;KSLQEALQNQLK;MLLPPRNIASKLPDAAAK;SLQEALQNQLK 5 19.2 0.97613 -2.3387 11.746 6.14209 0 13.4902 13.3787 0 0 10.589 7.50684 0 0 0 Q86TG7 PEG10_HUMAN Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) PEG10 EDR KIAA1051e MAR2 MART2 MEF3L1 RGAG3 Homo sapiens (Human) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein homooligomerization [GO:0051260]; vesicle-mediated intercellular transport [GO:0110077]; viral translational frameshifting [GO:0075523] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AARWASAK 1 1.1 0.94455 -0.63966 0 13.2362 13.2361 0 0 0 0 10.3922 0 0 0 0 Q86TH1 ATL2_HUMAN ADAMTS-like protein 2 (ADAMTSL-2) ADAMTSL2 KIAA0605 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; lobar bronchus epithelium development [GO:0060481]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] microfibril binding [GO:0050436] CYQGTDIVRGCDPLVKPVGR;GVCVSGK;TCGVGVRMR;VNLCGHWYYSKACCR 4 5.4 0.97622 -2.2946 0 0 9.13663 10.4237 0 5.34138 0 0 0 0 0 0 Q86TI0 TBCD1_HUMAN TBC1 domain family member 1 TBC1D1 KIAA1108 Homo sapiens (Human) Golgi apparatus [GO:0005794]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] HSWRQQIFLR;LDMLKNK;LLHDYHR;MHSAVGQGVPRHHRGEIWK;SALLQTVEELRR 5 4.7 0.98028 -2.0189 0 7.29939 10.106 6.7339 0 8.49149 0 0 0 0 0 0 Q86TI2 DPP9_HUMAN Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) DPP9 DPRP2 Homo sapiens (Human) negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269] cell leading edge [GO:0031252]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236] LVYFQGTK;SIIHGSR 2 1.7 0.95679 -1.0253 0 0 0 0 0 0 0 11.7397 11.5867 0 0 0 Q86TI4 WDR86_HUMAN WD repeat-containing protein 86 WDR86 Homo sapiens (Human) GARKPGR;SLESCGGCSGATHSSSTASR 2 9.7 0.87036 -0.096074 9.47188 5.59222 0 0 0 10.1506 0 0 0 0 0 0 Q86TI4 WDR86_HUMAN WD repeat-containing protein 86 WDR86 Homo sapiens (Human) GSPGGRR;GVCAHVHGPQTQR 2 4.1 0.76873 0.057523 0 0 0 0 9.04764 0 10.7752 0 0 0 0 10.3635 Q86TJ2 TAD2B_HUMAN Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) TADA2B ADA2B Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] ACIPDTIPNR;YHGYQLVDGGR 2 5 0.93034 -0.47994 0 0 10.0677 0 0 0 5.17121 0 0 0 0 0 Q86TJ5 ZN554_HUMAN Zinc finger protein 554 ZNF554 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EALWIEEK;TYKIIDCGKAFYQNR 2 4.3 0.91007 -0.31634 8.57259 0 0 9.56388 0 0 0 0 10.1993 0 10.1439 0 Q86TL0 ATG4D_HUMAN "Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]" ATG4D APG4D AUTL4 Homo sapiens (Human) aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein processing [GO:0016485]; protein transport [GO:0015031]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type exopeptidase activity [GO:0070004]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786] RRPEARRPR;VLSSSSATER 2 4 0.98079 -1.7493 0 0 0 0 13.4294 0 0 0 0 0 0 0 Q86TL2 STIMA_HUMAN Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) STIMATE TMEM110 Homo sapiens (Human) activation of store-operated calcium channel activity [GO:0032237]; store-operated calcium entry [GO:0002115] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020] calcium channel regulator activity [GO:0005246] GANQDSRNGSK;GLPGGPPSTVASGAGR;IWFLDTSK 3 11.9 0.97447 -2.4091 0 0 0 0 10.2503 0 0 0 0 0 0 0 Q86TM3 DDX53_HUMAN Probable ATP-dependent RNA helicase DDX53 (EC 3.6.4.13) (Cancer-associated gene protein) (Cancer/testis antigen 26) (CT26) (DEAD box protein 53) (DEAD box protein CAGE) DDX53 CAGE Homo sapiens (Human) cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] QTVMTSATWPDTVR;SITYLVIDEADK;VIMFVSQK 3 5.4 0.97374 -1.3994 0 12.2942 8.96653 0 8.65288 0 0 0 0 9.5012 0 0 Q86TM6 SYVN1_HUMAN E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1) SYVN1 HRD1 KIAA1810 Homo sapiens (Human) "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; immature B cell differentiation [GO:0002327]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; smooth endoplasmic reticulum [GO:0005790] ATPase binding [GO:0051117]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-specific protease binding [GO:1990381]; unfolded protein binding [GO:0051082] AVTDAIMSR;VHTFPLFAIRPMYLAMR 2 4.2 0.95248 -0.67109 0 11.6122 6.73606 0 0 0 0 0 0 0 0 0 Q86TN4 TRPT1_HUMAN tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Homo sapiens (Human) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" tRNA 2'-phosphotransferase activity [GO:0000215] NFSGGGRQEAAGSR;QEAAGSRGR 2 6.3 0.97851 -1.923 0 8.51266 0 7.6011 0 0 0 0 0 0 0 0 Q86TP1 PRUN1_HUMAN Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) PRUNE1 PRUNE Homo sapiens (Human) regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] exopolyphosphatase activity [GO:0004309]; inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631] ATPKDSK;IPSGQPETADVSREQVDK 2 5.5 0.96559 -1.2426 0 0 0 0 0 0 0 0 0 0 13.6991 0 Q86TU6 CN070_HUMAN Putative uncharacterized protein encoded by LINC00523 LINC00523 C14orf70 Homo sapiens (Human) SKQNLKDEEK 1 9.5 0.76502 0.06162 0 0 0 0 0 0 0 0 9.53914 9.72828 0 0 Q86TV6 TTC7B_HUMAN Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) TTC7B TTC7L1 Homo sapiens (Human) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; plasma membrane [GO:0005886] EALNIYAR;EQDVITCYEKAGDIALLYLQEIERVILSNIQNR;LALILHQLGR 3 6 0.95186 -0.74531 0 0 0 0 5.8928 0 0 0 0 5.75526 0 0 Q86TW2 ADCK1_HUMAN AarF domain-containing protein kinase 1 (EC 2.7.-.-) ADCK1 Homo sapiens (Human) lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of cristae formation [GO:1903852] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] KNTCSFFRR;NLPLELDFLNEGR 2 4.2 0.93647 -0.5582 0 0 0 0 0 10.4541 0 8.56647 0 0 0 0 Q86TY3 ARMD4_HUMAN Armadillo-like helical domain-containing protein 4 (Upstream of mTORC2 protein) ARMH4 C14orf37 Homo sapiens (Human) regulation of inflammatory response [GO:0050727]; regulation of TORC2 signaling [GO:1903939] membrane [GO:0016020] TORC2 complex binding [GO:1904841] EMLTTNPK 1 1 0.91343 -0.39033 0 0 0 0 0 0 0 0 0 0 0 10.8575 Q86TZ1 TTC6_HUMAN Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 C14orf25 NCRNA00291 Homo sapiens (Human) YEEAKEDFANVIESCPFWAAVYFNR 1 4.8 0.83924 -0.039211 0 0 0 0 0 0 0 7.85512 0 0 0 0 Q86U02 CN165_HUMAN Putative uncharacterized protein encoded by LINC00596 LINC00596 C14orf165 Homo sapiens (Human) membrane [GO:0016020] MFTLLLSNYYSR 1 10.3 0.8085 0.011301 0 0 6.93711 0 0 0 0 0 0 0 0 0 Q86U06 RBM23_HUMAN Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) RBM23 RNPC4 PP239 Homo sapiens (Human) "mRNA processing [GO:0006397]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]" membrane [GO:0016020]; nucleus [GO:0005634] RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446] GVGAIIK 1 1.7 0.64518 0.17143 0 0 0 0 0 0 0 0 0 8.5499 0 0 Q86U10 LPP60_HUMAN 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)] ASPG C14orf76 Homo sapiens (Human) aspartate family amino acid metabolic process [GO:0009066]; lipid catabolic process [GO:0016042] cytosol [GO:0005829] "1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; asparaginase activity [GO:0004067]; lysophospholipase activity [GO:0004622]" LSYVLGQPGLSLDVRKELLTK 1 3.7 0.5311 0.18665 0 0 0 0 0 0 0 0 0 9.24486 0 0 Q86U38 NOP9_HUMAN Nucleolar protein 9 NOP9 C14orf21 KIAA2021 Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]" "90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723] LLGSAAEEEEEEEEDGK;RVLQNLK 2 3.8 0.94131 -0.60027 0 0 0 0 0 0 0 4.96195 0 0 0 0 Q86U42 PABP2_HUMAN Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) PABPN1 PAB2 PABP2 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of polynucleotide adenylyltransferase activity [GO:1904247]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063] AAAAAAAAAAGAAGGR;TNRPGISTTDRGFPR;VREMEEEAEKLK 3 14.1 0 51.015 9.92062 10.3198 10.6991 3.72694 6.91349 9.82753 9.80137 10.7221 9.71098 7.91803 11.1221 0 Q86U44 MTA70_HUMAN N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) METTL3 MTA70 Homo sapiens (Human) "cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA destabilization [GO:0061157]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047] AQVQEFCDYGTK;LSPGTRK;TGHWLNHGK;TGRTGHWLNHGK;VSQEILELLNTTTAK 5 7.9 0.97566 -1.4604 0 0 0 10.0101 0 4.61129 0 0 11.1347 0 0 10.803 Q86U70 LDB1_HUMAN LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) LDB1 CLIM2 Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; cell adhesion [GO:0007155]; cellular component assembly [GO:0022607]; cerebellar Purkinje cell differentiation [GO:0021702]; epithelial structure maintenance [GO:0010669]; gastrulation with mouth forming second [GO:0001702]; hair follicle development [GO:0001942]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of cell adhesion [GO:0045785]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; Wnt signaling pathway [GO:0016055] beta-catenin-TCF complex [GO:1990907]; cell leading edge [GO:0031252]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] MSGGSTMSSGGGNTNNSNSKK 1 5.1 0.32609 0.24526 0 7.14262 0 0 0 0 0 0 0 0 0 0 Q86U86 PB1_HUMAN Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; DNA binding [GO:0003677] DIDLLAKNAK;EPSPLLEKKIQLLEAK;IEKVWVR;IRSHMMANK;LQQVMQAK;RKINMSGYILFSSEMR;SIHAMAK;VAEQQERER;VASVFANADK 9 5.4 0.93643 -0.52676 0 0 6.72479 0 0 0 0 0 0 0 0 0 Q86U86 PB1_HUMAN Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; DNA binding [GO:0003677] DIDLLAKNAK;EPSPLLEKKIQLLEAK;IEKVWVR;IRSHMMANK;LQQVMQAK;LWEDSAEK;RKINMSGYILFSSEMR;SIHAMAK;VASVFANADK 9 5.8 0.97608 -5.2847 0 0 0 0 12.1937 0 9.66963 6.72697 0 4.68207 3.63471 0 Q86UA1 PRP39_HUMAN Pre-mRNA-processing factor 39 (PRP39 homolog) PRPF39 Homo sapiens (Human) mRNA 5'-splice site recognition [GO:0000395] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] DLLTGEQFIQLRR;HLFKIQKNLPK;LWEMYINWENEQGNLREVTAIYDR 3 7.2 0.77886 0.039412 0 0 0 5.56846 0 4.40518 0 9.19446 0 0 10.267 0 Q86UB2 BIVM_HUMAN Basic immunoglobulin-like variable motif-containing protein BIVM Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] SFSASFHQDSAWKK 1 2.8 0.39609 0.21164 0 0 0 0 6.23573 0 0 0 4.62129 6.9493 0 0 Q86UB9 TM135_HUMAN Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) TMEM135 Homo sapiens (Human) mitochondrion organization [GO:0007005]; peroxisome organization [GO:0007031]; regulation of mitochondrial fission [GO:0090140]; regulation of oxidative phosphorylation [GO:0002082]; response to cold [GO:0009409]; response to food [GO:0032094]; retinal pigment epithelium development [GO:0003406] lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] FVDSICKHGPR;IYAPLYLIAAILRKR 2 5.7 0.96655 -1.282 0 0 0 0 0 0 0 7.82197 0 0 11.0144 8.62622 Q86UC2 RSPH3_HUMAN Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) RSPH3 RSHL2 RSP3 Homo sapiens (Human) 9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; radial spoke head [GO:0001535] ALPCQRSR;SQEPEVPCAAVLPGKPGDR 2 4.8 0.9751 -1.3913 0 0 0 0 0 0 0 12.7176 12.6667 0 0 0 Q86UD0 SAPC2_HUMAN Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) SAPCD2 C9orf140 Homo sapiens (Human) establishment of mitotic spindle orientation [GO:0000132]; negative regulation of protein localization to cell cortex [GO:1904777]; positive regulation of cell population proliferation [GO:0008284]; regulation of establishment of planar polarity [GO:0090175]; symmetric cell division [GO:0098725] apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DWYQQQLQRVQERQR;GVLEGLR;TLFDILDDRRR 3 8.4 0.9678 -1.3201 13.3058 0 0 0 0 0 0 0 10.0686 0 0 0 Q86UD1 OAF_HUMAN Out at first protein homolog (HCV NS5A-transactivated protein 13 target protein 2) OAF NS5ATP13TP2 Homo sapiens (Human) MRLPGVPLARPALLLLLPLLAPLLGTGAPAELRVR;YGLSLAWYPCMLK 2 17.6 0.3959 0.21139 0 0 0 0 0 0 0 0 4.00764 5.00841 0 0 Q86UD3 MARH3_HUMAN E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3) MARCHF3 MARCH3 RNF173 Homo sapiens (Human) endocytosis [GO:0006897]; protein ubiquitination [GO:0016567] early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LYNEWRR;TLATQSPFNDRPMCR 2 8.7 0.92127 -0.44151 8.34775 0 0 10.0532 0 0 0 0 10.0249 0 0 0 Q86UD4 ZN329_HUMAN Zinc finger protein 329 ZNF329 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] LFRNIAGLIRHQR;MFQKSSSLVRHQR;QYRCTECGKCFK 3 7 0.98062 -1.6337 0 11.6904 0 0 0 0 8.35887 0 0 0 0 0 Q86UD5 SL9B2_HUMAN Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) SLC9B2 NHA2 NHEDC2 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; flagellated sperm motility [GO:0030317]; inorganic cation transmembrane transport [GO:0098662]; lithium ion transport [GO:0010351]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of osteoclast development [GO:2001206]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; sperm principal piece [GO:0097228]; synaptic vesicle membrane [GO:0030672] identical protein binding [GO:0042802]; lithium:proton antiporter activity [GO:0010348]; sodium:proton antiporter activity [GO:0015385] LLGLIKLPTLPPLPSLLGMLLAGFLIR 1 5 0.84104 -0.045996 0 0 0 0 0 0 0 0 0 7.76275 0 0 Q86UD7 TBC26_HUMAN TBC1 domain family member 26 TBC1D26 Homo sapiens (Human) GTPase activator activity [GO:0005096] AGAAVDLGHEQVDVR;LSQRVYKVIPLAVR;WQKMLADWTK 3 15.6 0.96355 -1.096 9.8401 0 0 0 0 0 5.14849 0 0 0 0 0 Q86UE3 ZN546_HUMAN Zinc finger protein 546 (Zinc finger protein 49) ZNF546 ZNF49 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HHRIHTCEKPYECKECGK;LQTELTR;LTLHQRIHTGELPYECK;NTIHEDTIFR 4 6.2 0.97388 -1.3983 8.67486 0 8.83384 0 0 0 8.67133 9.94024 9.3923 0 0 0 Q86UE4 LYRIC_HUMAN Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) MTDH AEG1 LYRIC Homo sapiens (Human) lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; intercellular canaliculus [GO:0046581]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] double-stranded RNA binding [GO:0003725]; NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] EVDEGAWETKISHR;SNTKQNSVPPSQTK;TISTSDPAEVLVK;TVEVAEGEAVR 4 8.9 0.96074 -1.0571 0 12.1999 0 0 0 0 0 10.6991 0 0 0 0 Q86UE6 LRRT1_HUMAN Leucine-rich repeat transmembrane neuronal protein 1 LRRTM1 UNQ675/PRO1309 Homo sapiens (Human) establishment of localization in cell [GO:0051649]; exploration behavior [GO:0035640]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; receptor internalization [GO:0031623]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse organization [GO:0050808] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic specialization membrane [GO:0099634] LTTLHMRANAIQFVPVRIFQDCR;LTYIEPR 2 5.7 0.97954 -1.5464 0 0 0 0 0 0 0 0 9.94721 0 0 0 Q86UE8 TLK2_HUMAN Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) TLK2 Homo sapiens (Human) cellular response to gamma radiation [GO:0071480]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nucleus localization [GO:0051647]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275] intermediate filament [GO:0005882]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ISDYFER;LDTEQLAQR;SMQDRLRLGHFTTVR 3 4.3 0.97455 -2.3897 0 0 0 0 9.85094 0 0 0 0 0 0 0 Q86UF2 CTGE6_HUMAN cTAGE family member 6 (Protein cTAGE-6) CTAGE6 CTAGE6P Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] DLEEELERTVHFYQK;LNRSNSELEDEILCLEKDLK;LSGSAEPRSFK;LTVEENYR;LTVEENYRIEEEEK;MTSLDKMDGSMPSEMESSR 6 10.2 0.97342 -2.6391 0 9.99831 0 9.30686 0 0 0 13.1352 9.93152 0 10.7701 0 Q86UF4 CC190_HUMAN Coiled-coil domain-containing protein 190 CCDC190 C1orf110 Homo sapiens (Human) LLTWEQR;QAEARLDQRLQR;VICLYHVK 3 8.9 0.97937 -1.853 0 0 0 10.3326 10.771 9.79172 11.219 0 0 0 0 0 Q86UG4 SO6A1_HUMAN Solute carrier organic anion transporter family member 6A1 (Cancer/testis antigen 48) (CT48) (Gonad-specific transporter) (GST) (Organic anion-transporting polypeptide 6A1) (Organic anion-transporting polypeptide I) (OATP-I) (Solute carrier family 21 member 19) SLCO6A1 OATP6A1 SLC21A19 Homo sapiens (Human) sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323] sodium-independent organic anion transmembrane transporter activity [GO:0015347] DVNKCGHTGR;RKQLHFFDSR 2 2.8 0.87659 -0.12553 0 0 10.6897 0 0 0 0 0 0 7.31569 0 0 Q86UK0 ABCAC_HUMAN Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12) ABCA12 ABC12 Homo sapiens (Human) cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129] cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102] DIKETVHK;DLRFDITGVPANR;IVFQEIVR;LKEILNQMASGTHPLLDKMR;LRLFFRK;LTKEQIASK;SIWDVISK;SKLSQLR;VTMETLTK;YTIRMSLK 10 3.7 0.97878 -10.465 0 0 7.93693 8.81967 4.04684 0 13.8959 0 9.21609 10.5338 9.01148 0 Q86UK5 LBN_HUMAN Limbin (Ellis-van Creveld syndrome protein 2) (EVC2) EVC2 LBN Homo sapiens (Human) smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane protein complex [GO:0098797] QFLLLENEIQEEYDRK;TAVEAPLGMKLDK;TLTLSLFEK;VLLQQFQTAWREAEFVK 4 4.2 0.93504 -0.53022 0 12.2465 11.9521 0 7.73809 7.6153 8.79714 0 0 0 0 0 Q86UK7 ZN598_HUMAN E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) ZNF598 Homo sapiens (Human) negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase regulator activity [GO:0055106] EVAAAVR;NLQLIQSIR;QVVFGKKLPAFATIPIHQLQHEK 3 4.3 0.95384 -0.89123 0 0 10.7374 10.313 0 0 0 7.43496 0 0 0 11.1771 Q86UK7 ZN598_HUMAN E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) ZNF598 Homo sapiens (Human) negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase regulator activity [GO:0055106] VGGCGQPQVGAGRAGMEPR 1 5.6 0.82334 -0.018847 0 0 0 0 0 0 0 0 8.62224 0 0 0 Q86UL8 MAGI2_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)" MAGI2 ACVRINP1 AIP1 KIAA0705 Homo sapiens (Human) "cellular response to nerve growth factor stimulus [GO:1990090]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; podocyte development [GO:0072015]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor internalization [GO:0002092]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; late endosome [GO:0005770]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]; synapse [GO:0045202] beta-1 adrenergic receptor binding [GO:0031697]; phosphatase binding [GO:0019902]; signaling receptor complex adaptor activity [GO:0030159]; SMAD binding [GO:0046332]; type II activin receptor binding [GO:0070699] DMTHARAIELIKSGGR;GFGFSIRGGREYK;LAEDGPAIR 3 2.6 0.97309 -2.877 12.9513 0 0 5.02179 6.21587 7.92511 0 0 0 10.4782 0 0 Q86UN6 AKA28_HUMAN A-kinase anchor protein 14 (AKAP-14) (A-kinase anchor protein 28 kDa) (AKAP 28) (Protein kinase A-anchoring protein 14) (PRKA14) AKAP14 AKAP28 Homo sapiens (Human) axoneme [GO:0005930]; cAMP-dependent protein kinase complex [GO:0005952] protein kinase A regulatory subunit binding [GO:0034237] ISAGTYFTMK;NIKWMTHGEFTVEK 2 12.2 0.95578 -0.86961 0 0 10.6804 0 0 0 0 9.53574 0 0 0 0 Q86UP0 CAD24_HUMAN Cadherin-24 CDH24 CDH11L UNQ2834/PRO34009 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097] SLDREEK 1 0.9 0.89866 -0.25692 0 0 0 0 0 7.6517 0 0 0 0 0 0 Q86UP2 KTN1_HUMAN Kinectin (CG-1 antigen) (Kinesin receptor) KTN1 CG1 KIAA0004 Homo sapiens (Human) microtubule-based movement [GO:0007018]; protein transport [GO:0015031] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; kinesin binding [GO:0019894]; RNA binding [GO:0003723] AEMERSTYVTEVRELK;AQQLSITSK;DIQNMNFLLK;EFYESAYFIVLIPSIVITVIFLFFWLFMK;ELKDLLTELQKK;QKVAGDLHK;QQQVEAVELEAK;SENKDIENLRR;VAGDLHK;VKVDESHKTIK 10 8.5 0.97779 -6.0084 0 10.972 0 9.10106 9.79266 0 9.62225 9.76115 0 10.6803 10.253 7.08044 Q86UP3 ZFHX4_HUMAN Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) ZFHX4 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ASPVGSDSSSIPDDMGSEPK;DQENNCERPK;DSGIITPEK;EPLISFLEPK;FCHEQFYQCPYCNYNSR;GSASTSSSAEQPLGITQMPK;KIKEEELEATKPEK;LDDKEDNNCSEK;LEDLDNSLEVK;LYKHLQK;NSCKTLKCPK;SMAGLEDSK;STATESTK;VIKHWFR;VYDLRHK 15 4.8 0.97809 -6.1154 6.26581 0 8.23376 0 11.6917 0 0 11.0662 12.5149 10.253 9.07951 7.20006 Q86UP8 GTD2A_HUMAN General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) GTF2IRD2 GTF2IRD2A Homo sapiens (Human) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" IAGKTSTVFSSK 1 11.1 0.92263 -0.44718 0 0 0 0 0 0 0 10.2732 0 0 0 0 Q86UP8 GTD2A_HUMAN General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) GTF2IRD2 GTF2IRD2A Homo sapiens (Human) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" YRPSVVAHACNPSNLGGRGRR 1 8.2 0.85956 -0.081679 0 0 0 7.31388 0 0 0 0 0 0 0 0 Q86UQ4 ABCAD_HUMAN ATP-binding cassette sub-family A member 13 (EC 7.6.2.-) ABCA13 Homo sapiens (Human) ceramide transport [GO:0035627]; lipid transport [GO:0006869]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of synaptic vesicle endocytosis [GO:1900244] azurophil granule membrane [GO:0035577]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] ALLWKNWLCR;DLATSMDSIVKLLKLVK;DVFFWELKQMLAKNAVCPNGR;EAYGQGLRLTLTR;IVTWVLNIK;LKTLSETLLEMSSLFQR;RFFQNIIAVQDISLGIPK;SINSMALQK;TNGDILVLYNLSK;TVQKFWHK;VIENNKTFLNIK;VLLHWDLLRWPR 12 3.1 0.97513 -4.0168 0 0 0 9.81684 0 7.77952 0 7.67165 11.4078 0 8.81035 10.8899 Q86UQ8 NFE4_HUMAN Transcription factor NF-E4 NFE4 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA-binding transcription factor binding [GO:0140297]; protein homodimerization activity [GO:0042803]; transcription coregulator activity [GO:0003712] ISSALPLK 1 4.5 0.74667 0.10231 0 0 8.20109 0 0 0 0 0 0 3.90111 0 0 Q86UR1 NOXA1_HUMAN NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) NOXA1 P51NOX Homo sapiens (Human) regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] cytosol [GO:0005829]; NADPH oxidase complex [GO:0043020] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; superoxide-generating NADPH oxidase activator activity [GO:0016176] DTCMAVGFFQR;GVANFQLAR;MSGAPGR;SQQGDQP 4 7.1 0.9563 -0.9933 0 5.9181 0 0 0 0 7.69815 0 8.39086 0 4.95317 0 Q86UR5 RIMS1_HUMAN Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) RIMS1 KIAA0340 RAB3IP2 RIM1 Nbla00761 Homo sapiens (Human) acrosomal vesicle exocytosis [GO:0060478]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; protein-containing complex assembly [GO:0065003]; regulated exocytosis [GO:0045055]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300]; secretion [GO:0046903]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]; visual perception [GO:0007601] cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] GTPase regulator activity [GO:0030695]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882] ATDQPVIR;GRQLPQVPVR;LSSTSFMSEQSERPRGR;NIIMAVMDRQKEEEEK;QKEEEEKEEAMLK;SERSSIQKQTR 6 4 0.97595 -4.3172 0 0 13.265 8.94372 10.6538 6.24077 0 0 10.8911 9.74313 0 14.6656 Q86US8 EST1A_HUMAN Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) SMG6 C17orf31 EST1A KIAA0732 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]" DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] AEQMEKK;AGGYARVVQEK;DFMPASK;KIAEQQRR;KSIEFLEQR;LDAVYYYMR;RFILSFLHAHGKLFTR;YALISAQR 8 5.3 0.97691 -5.6161 0 0 0 0 8.17188 0 9.72265 9.63012 0 12.8409 0 0 Q86UT6 NLRX1_HUMAN NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9) NLRX1 NOD5 NOD9 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of RIG-I signaling pathway [GO:0039536] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524] LAYEGVSSR;LLPLRALPLLFNLIK;LLPLRALPLLFNLIKVVPR;STLVRKMVLDWCYGR 4 4.4 0.97878 -1.904 7.886 0 0 0 8.96339 7.64803 0 0 0 0 3.36555 0 Q86UT8 CATAC_HUMAN Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) CENATAC CCDC84 DLNB14 Homo sapiens (Human) "chromosome separation [GO:0051304]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centrosome duplication [GO:0010826]; regulation of protein catabolic process [GO:0042176]" centrosome [GO:0005813]; cytoplasm [GO:0005737] VGANFDHSSR 1 3 0.89778 -0.23949 6.47432 0 7.80432 0 0 0 0 0 7.71692 0 0 0 Q86UU0 BCL9L_HUMAN B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) BCL9L DLNB11 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366] beta-catenin-TCF complex [GO:1990907]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] ALRFCAGLCVCCISVF;LQEEYYEEKRR 2 1.9 0.97514 -1.4391 0 0 0 0 0 0 10.6145 0 9.18507 0 0 0 Q86UU1 PHLB1_HUMAN Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) PHLDB1 KIAA0638 LL5A DLNB07 Homo sapiens (Human) positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507] basal cortex [GO:0045180]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ALLQGEREAER;EECSSTESTQQEHEDAPSTK;ELPPLSPSLSRR;EVKMREK;GLDSMRELPPLSPSLSRR;GYLVKMGGKIK;LETILNLCAEYSR;LVALETGIQKERDK;NASLQLLQKEKEK;NQIGPGCQTQTMVQK;QQLVEKEVK;VLTTSPSRQLVGR 12 10.2 0.97698 -5.6869 7.53201 0 0 8.36955 6.11913 10.6797 0 11.345 0 8.91704 0 12.5997 Q86UU5 GGN_HUMAN Gametogenetin GGN Homo sapiens (Human) cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283] ubiquitin protein ligase binding [GO:0031625] HFRFNGAGGGIGAPRR 1 2.5 0.84915 -0.070302 11.1642 0 0 0 0 0 0 0 0 0 0 0 Q86UU5 GGN_HUMAN Gametogenetin GGN Homo sapiens (Human) cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283] ubiquitin protein ligase binding [GO:0031625] TRGCAHQDPHAQEQGFPCSPGR 1 9.8 0.82924 -0.025381 0 0 0 0 0 0 0 0 0 7.31397 0 0 Q86UV5 UBP48_HUMAN Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48) USP48 USP31 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005] ALCKECVVER;ECCSQCKILER;LLSLPCTLNLQLMRFVFDRQTGHK;QSVDKGK;RISEYAADIFYSR 5 6.3 0.97309 -2.5787 0 13.7819 0 5.62755 0 0 0 0 0 6.73931 0 0 Q86UV5 UBP48_HUMAN Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48) USP48 USP31 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005] LLSLPCTLNLQLMRFVFDRQTGHK;LPAGAGL;QSVDKGK 3 7.8 0.68633 0.16249 0 5.93525 0 0 8.10999 0 7.18597 0 7.33575 11.0262 8.18992 6.85387 Q86UW1 OSTA_HUMAN Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha) SLC51A OSTA Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782] basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857] DTPMMVHTGPCCCCCPCCPR 1 5.9 0.63766 0.17351 0 6.43821 0 0 0 0 0 0 0 0 0 0 Q86UW6 N4BP2_HUMAN NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) N4BP2 B3BP KIAA1413 Homo sapiens (Human) cytosol [GO:0005829] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; ubiquitin binding [GO:0043130] EKKDFEYPDYDDYR;EPDTWWKFKPKELAR;ETLMFEKDCATK;FSDEEEFMNEDEK;KTSYVGLVLVLLRGLPGSGK;RETLMFEK;SRMPKTGLSEPNLEIGTNDK;TIGQRTK 8 5.8 0.98063 -1.6093 7.74873 9.43888 0 8.85972 9.87546 0 0 10.0775 0 0 12.6269 8.47513 Q86UW7 CAPS2_HUMAN Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) CADPS2 CAPS2 KIAA1591 Homo sapiens (Human) dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; presynapse [GO:0098793] lipid binding [GO:0008289]; metal ion binding [GO:0046872] DSDEEEEG;FVSVLEGVLSKLSRYDEGTFFSSILSFTVK;IVYCTMEVEGEK;KQSTKLCALDGGQEFGSQWQQYHSK;LDLQLHIYQLKTLIK;LDLQLHIYQLKTLIKIVK;VNEEMYIEK 7 8.1 0.92888 -0.47037 0 8.39797 0 10.4023 5.23951 0 8.04816 11.423 11.4844 0 0 0 Q86UW9 DTX2_HUMAN Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) DTX2 KIAA1528 RNF58 Homo sapiens (Human) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] HLFPQHSAPGR;HSMTNLPAYPVPQHPPHR 2 4.7 0.92883 -0.46191 0 0 0 0 0 8.24184 0 8.2744 0 0 0 0 Q86UX2 ITIH5_HUMAN Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5) ITIH5 KIAA1953 PP14776 UNQ311/PRO354 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] GAGTQPGPLLKKPYQPRIK;LDHLHVEVTASNSK;LSLENCGLTR 3 4.6 0.93396 -0.51538 0 0 0 0 0 0 11.033 0 0 0 11.9921 0 Q86UX2 ITIH5_HUMAN Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5) ITIH5 KIAA1953 PP14776 UNQ311/PRO354 Homo sapiens (Human) hyaluronan metabolic process [GO:0030212] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] GAGTQPGPLLKKPYQPRIK;ISKTSGKAK;LDHLHVEVTASNSK 3 17.2 0.98044 -1.6422 0 0 0 0 10.2848 0 0 0 0 0 9.5289 10.0479 Q86UX7 URP2_HUMAN Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) FERMT3 KIND3 MIG2B URP2 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446] cell projection [GO:0042995]; cell-substrate junction [GO:0030055]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; podosome [GO:0002102] integrin binding [GO:0005178]; lipid binding [GO:0008289] AGDALWLR;FIQAWQSLPDFGISYVMVR;IVHEYIGGYIFLSTRER;KQDWSDHAIWWEQK 4 8.7 0.91647 -0.36469 0 0 0 0 0 0 0 0 0 0 9.60192 10.4429 Q86UY5 FA83A_HUMAN Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) FAM83A TSGP Homo sapiens (Human) cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] FIISDWR;SQWVRPAR 2 3.5 0.95198 -0.71063 11.1131 0 0 0 0 0 0 0 0 0 9.72033 0 Q86UY6 NAA40_HUMAN N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD) (hNatD) (Protein acetyltransferase 1) NAA40 NAT11 PATT1 Homo sapiens (Human) lipid metabolic process [GO:0006629] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189] FGDSHHSHAGGHCGGCCH 1 7.6 0.67575 0.16632 0 0 0 4.31143 0 0 0 0 0 0 0 7.54496 Q86UY8 NT5D3_HUMAN 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) NT5DC3 GNN TU12B1-TY Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; receptor complex [GO:0043235] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] AIEADIEKYICYAEQTR;YICYAEQTR;YLWERYR;YLWERYREAK 4 4.9 0.9813 -1.773 0 10.6844 0 5.17013 0 0 8.86471 0 8.89896 0 0 10.7599 Q86UZ6 ZBT46_HUMAN Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) ZBTB46 BTBD4 ZNF340 Homo sapiens (Human) granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of dendritic cell differentiation [GO:2001200]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]" EDMEITSHYRHLLR 1 2.4 0.92199 -0.44279 0 0 0 0 0 0 0 7.7911 0 0 0 0 Q86V15 CASZ1_HUMAN Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) CASZ1 CST SRG ZNF693 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ALVQEKLAEPWK;CSHFHCTFPGCR;STHYHCMQVGCNK 3 2.1 0.97839 -2.1276 0 0 14.6806 0 0 0 0 0 0 5.21715 0 0 Q86V20 SHLD2_HUMAN Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) SHLD2 FAM35A RINN2 Homo sapiens (Human) DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; regulation of double-strand break repair via homologous recombination [GO:0010569]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] SCTSEDK;VGQSEALSRVLQVAKK 2 2.8 0.8782 -0.13836 0 0 0 0 0 7.63249 0 0 0 0 9.14305 0 Q86V21 AACS_HUMAN Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) AACS ACSF1 Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; ketone body biosynthetic process [GO:0046951]; positive regulation of insulin secretion [GO:0032024] cytosol [GO:0005829] acetoacetate-CoA ligase activity [GO:0030729]; ATP binding [GO:0005524] AMKPVETHSLQMLHTILSTGSPLK;EGKEEIVKVTFEELR;QESGSCR;SDGTLNPNGVR 4 9.5 0.97612 -2.2545 0 0 0 0 5.97375 0 5.46343 0 8.47094 0 0 0 Q86V40 TIKI1_HUMAN Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A) TRABD2A C2orf89 TIKI1 Homo sapiens (Human) head development [GO:0060322]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147] ITAQEIDSYLRRELIYK 1 3.4 0.48579 0.18986 0 0 0 0 0 0 7.7709 0 0 0 0 0 Q86V48 LUZP1_HUMAN Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) LUZP1 Homo sapiens (Human) apical constriction [GO:0003383]; artery development [GO:0060840]; contractile ring contraction [GO:0036213]; negative regulation of cilium assembly [GO:1902018]; neural fold bending [GO:0021503]; protein localization to actin cytoskeleton [GO:1903119]; regulation of protein complex stability [GO:0061635]; stress fiber assembly [GO:0043149]; ventricular septum development [GO:0003281] "actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; centrosome [GO:0005813]; CERF complex [GO:0090537]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; stress fiber [GO:0001725]; tight junction [GO:0070160]" actin filament binding [GO:0051015]; microtubule binding [GO:0008017] AEFTSYK;APVLSKYPYSCR;GGLDYLK;GGLDYLKQVENETR;IEDGISSTLPSK;ISSELEMLR;LEEEENLTRELK;SVRASTNTMELPDTNGAGVK;YLNEKEK 9 8.6 0.97609 -4.6137 12.0389 0 7.70736 0 6.75261 0 0 12.7023 11.4503 0 0 0 Q86V59 PNM8A_HUMAN Paraneoplastic antigen-like protein 8A (PNMA-like protein 1) PNMA8A PNMAL1 Homo sapiens (Human) NPERFDLGDHPY 1 3.2 0.88723 -0.18529 0 0 0 0 0 0 9.31145 0 0 0 0 10.7356 Q86V81 THOC4_HUMAN THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) ALYREF ALY BEF THOC4 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; osteoblast differentiation [GO:0001649]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380] catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346] C5-methylcytidine-containing RNA reader activity [GO:0062153]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] AAVHYDR;AGSQGGR;GAGGFGGGGGTR;GAGRNSK 4 12.8 0.95733 -0.84808 0 0 6.48954 0 0 0 9.06388 11.8866 0 8.56548 0 12.3241 Q86V87 FHI2B_HUMAN FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) FHIP2B FAM160B2 RAI16 FP13191 Homo sapiens (Human) EPSIDLLQAFVEHWK;IQRVPQFPGKLLLVR 2 4 0.95451 -0.90243 0 0 0 0 0 0 8.1102 9.51651 0 0 0 0 Q86V88 MGDP1_HUMAN Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) "acid phosphatase activity [GO:0003993]; histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" YFVHREIYPGSK 1 6.8 0.98156 -1.5895 0 0 0 0 0 0 0 0 0 0 10.4186 0 Q86V97 KBTB6_HUMAN Kelch repeat and BTB domain-containing protein 6 KBTBD6 Homo sapiens (Human) negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]; response to unfolded protein [GO:0006986] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LDLTNCTAILKFADAFGHR;LLLITSRTPQWKK 2 4.7 0.93603 -0.53234 0 0 6.7237 0 0 0 0 0 0 0 0 0 Q86VB7 C163A_HUMAN Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Homo sapiens (Human) acute-phase response [GO:0006953] cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] scaffold protein binding [GO:0097110]; scavenger receptor activity [GO:0005044] CKGNESSLWDCPARR;EAILSHTEK;GGNMCSGRIEIKFQGR;GNESSLWDCPAR;IWMDHVSCR;WGHSECGHK 6 5 0.97676 -2.1884 0 0 12.1189 0 0 7.30351 12.9534 0 0 8.09122 0 0 Q86VD1 MORC1_HUMAN MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33) MORC1 MORC Homo sapiens (Human) behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; epigenetic programing of male pronucleus [GO:0044727]; negative regulation of DNA-templated transcription initiation [GO:2000143]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposition [GO:0032197]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005] male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] zinc ion binding [GO:0008270] AEEAVKIAESILKEAQIK;GIHNEISLGQCENK;MDDRYPALQRAQLR;NAQAASWEMK;VLPSSTNYQEKEFFDIWICANNPNR;WSFRAYTSVLYFNPWMR 6 10 0.96444 -1.1722 0 9.33224 0 0 0 0 10.9953 0 9.30076 8.86406 0 6.78424 Q86VD7 S2542_HUMAN Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42) SLC25A42 Homo sapiens (Human) ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]; pantothenate metabolic process [GO:0015939] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ADP phosphatase activity [GO:0043262]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228] VLYYTYLNEGFLSLWR 1 5 0.78474 0.029621 0 0 0 8.17931 0 0 0 0 0 0 0 0 Q86VE0 MYPOP_HUMAN "Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin)" MYPOP P42POP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSFEENQILIR;INGITSWKRTGQEVQK 2 6.8 0.37801 0.21842 0 0 0 10.3557 0 0 0 0 12.6682 0 0 0 Q86VE9 SERC5_HUMAN Serine incorporator 5 SERINC5 C5orf12 Homo sapiens (Human) defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; myelination [GO:0042552]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] L-serine transmembrane transporter activity [GO:0015194] LVGYSAVYR;MSAQCCAGQLACCCGSAGCSLCCDCCPR;SAQCCAGQLACCCGSAGCSLCCDCCPR 3 8.7 0.96174 -1.0749 0 0 0 0 0 0 0 6.48259 0 0 0 10.2593 Q86VF2 IGFN1_HUMAN Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1) IGFN1 EEF1A2BP1 KYIP1 Homo sapiens (Human) nucleus [GO:0005634]; Z disc [GO:0030018] AGYRDGLR;AGYRGGLGSGEMGSVDK;AGYRKDLGAPK;DSNSDECWR;GDSGRQLDRHAPEQLWDAR;GIGSGSK;GKSDLQGCQSDPVGSWPR;GMGSGSK;GPRGETGYK;KDLGAPK;LCLPSAGRK;LREPLVVKAGKPVIVK;NLQVTDR 13 8.6 0.97826 -6.6052 4.68896 0 6.0169 5.93923 0 5.02432 10.4432 0 11.706 12.5104 11.169 8.6714 Q86VF7 NRAP_HUMAN Nebulin-related-anchoring protein (N-RAP) NRAP Homo sapiens (Human) cardiac muscle thin filament assembly [GO:0071691] fascia adherens [GO:0005916]; muscle tendon junction [GO:0005927]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; vinculin binding [GO:0017166] ASGDIASDFLYRHDFVK;DLASEVKYKEDYER;GFEESKTR;LHEYTVLPEDMKTQWAKK;LIGPQSVRDDPR;MKHFLNVGRLQSDNEYK;NAQALASDHDYR;QHPDALKFTSIK 8 6.4 0.97667 -2.1801 0 10.6726 10.6786 0 8.98465 9.41633 0 9.14254 0 8.58823 7.44303 10.5028 Q86VG3 IFTAP_HUMAN Intraflagellar transport-associated protein (Protein HEPIS) IFTAP C11orf74 NWC Homo sapiens (Human) acrosome reaction [GO:0007340]; spermatogenesis [GO:0007283] 9+0 non-motile cilium [GO:0097731]; cytosol [GO:0005829] intraciliary transport particle A binding [GO:0120160] GVFGTDSSENIFTSAK 1 7.2 0.78526 0.029314 0 0 0 0 0 0 0 0 8.58718 0 0 0 Q86VH2 KIF27_HUMAN Kinesin-like protein KIF27 KIF27 Homo sapiens (Human) cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; microtubule-based movement [GO:0007018]; ventricular system development [GO:0021591] cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DLYFYKK;LLREALQSQQAGVSQTTQINR;QISALELSLR;WASRPESMKLSGR;WLDEEVEKVLNQR 5 4.6 0.97853 -2.0982 0 11.9733 0 0 0 0 12.0916 0 8.36387 0 0 0 Q86VH4 LRRT4_HUMAN Leucine-rich repeat transmembrane neuronal protein 4 LRRTM4 UNQ3075/PRO9907 Homo sapiens (Human) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic membrane [GO:0045211] LKELHLEHNQFSKINFAHFPR 1 3.6 0.86473 -0.083824 0 0 0 0 0 0 0 0 0 5.03215 0 0 Q86VH5 LRRT3_HUMAN Leucine-rich repeat transmembrane neuronal protein 3 LRRTM3 UNQ803/PRO1693 Homo sapiens (Human) positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] NICSLVNWLK;SLMRRHR;STTERFDLAR 3 4.6 0.98036 -1.614 0 11.3676 0 9.5935 0 0 0 0 0 0 0 0 Q86VI1 EX3L1_HUMAN Exocyst complex component 3-like protein (Protein Jiangli) EXOC3L1 EXOC3L Homo sapiens (Human) exocyst localization [GO:0051601]; exocytosis [GO:0006887]; peptide hormone secretion [GO:0030072] exocyst [GO:0000145]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] SNARE binding [GO:0000149] GLLQGMSQALQTLEPLR 1 2.3 0.60922 0.17526 0 0 0 0 0 0 0 0 0 0 0 9.82442 Q86VI3 IQGA3_HUMAN Ras GTPase-activating-like protein IQGAP3 IQGAP3 Homo sapiens (Human) ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell size [GO:0008361] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; myosin VI light chain binding [GO:0070856]; small GTPase binding [GO:0031267] ACLDHLAPDSK;AFSGQSQHLR;FAEHSHFLR;GFLVRQKFAEHSHFLR;IQAHWRGYRQR;ITLQEVVSHCK;IYLEWLQYFK;LFNKAKVNVNLLIFLLNK;QQLWKANVGFVIQLQAR;TALQEEIK;VLNDYLEETHLKFRK;VTAAYDRQQLWKANVGFVIQLQAR 12 8.2 0.97479 -4.0709 14.434 0 5.09706 9.30895 0 7.9553 11.2812 0 10.1912 9.90254 0 8.9708 Q86VI4 LAP4B_HUMAN Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) LAPTM4B PSEC0001 Homo sapiens (Human) endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of transforming growth factor beta1 production [GO:0032911]; regulation of lysosomal membrane permeability [GO:0097213]; regulation of lysosome organization [GO:1905671] "cell projection [GO:0042995]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]" ceramide binding [GO:0097001]; kinase binding [GO:0019900]; phosphatidylinositol bisphosphate binding [GO:1902936]; ubiquitin protein ligase binding [GO:0031625] ATAPGAMK 1 2.5 0.9146 -0.39033 0 0 0 0 0 0 9.91379 0 0 0 0 0 Q86VI4 LAP4B_HUMAN Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) LAPTM4B PSEC0001 Homo sapiens (Human) endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of transforming growth factor beta1 production [GO:0032911]; regulation of lysosomal membrane permeability [GO:0097213]; regulation of lysosome organization [GO:1905671] "cell projection [GO:0042995]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]" ceramide binding [GO:0097001]; kinase binding [GO:0019900]; phosphatidylinositol bisphosphate binding [GO:1902936]; ubiquitin protein ligase binding [GO:0031625] MKMVAPWTRFYSNSCCLCCHVR 1 9.7 0.56231 0.18276 0 0 0 0 0 0 0 6.20424 0 0 0 0 Q86VK4 ZN410_HUMAN Zinc finger protein 410 (Another partner for ARF 1) ZNF410 APA1 Homo sapiens (Human) negative regulation of gene expression [GO:0010629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator activity [GO:0003712] VQELAHDSLIAATRAQLAK 1 4 0.98002 -1.5393 0 0 0 9.91234 0 9.75363 10.3904 10.2917 0 0 0 0 Q86VM9 ZCH18_HUMAN Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) ZC3H18 NHN1 Homo sapiens (Human) RNA destabilization [GO:0050779] nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] DWNSRIPR;EVLKKATIR;QLKAVEDAIAR;TSDLRDEASSVTR;VTSVPGK 5 5 0.97307 -2.9482 12.3001 0 0 0 10.401 0 0 9.9498 0 7.55267 12.6707 0 Q86VP1 TAXB1_HUMAN Tax1-binding protein 1 (TRAF6-binding protein) TAX1BP1 T6BP PRO0105 Homo sapiens (Human) apoptotic process [GO:0006915]; autophagy [GO:0006914]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; protein localization to phagocytic vesicle [GO:1905161] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407] kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] EEIGRLQLCLAEK;NLDGNKESVITHFK 2 3.4 0.94162 -0.61683 0 0 0 0 0 0 8.92523 0 0 0 0 9.11863 Q86VP3 PACS2_HUMAN Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) PACS2 KIAA0602 PACS1L Homo sapiens (Human) apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; protein localization to phagophore assembly site [GO:0034497]; protein localization to plasma membrane [GO:0072659] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] transmembrane transporter binding [GO:0044325] SIQQNFKQKVVALLR 1 1.8 0.45833 0.19122 0 0 0 0 0 4.83051 0 0 0 0 0 0 Q86VP6 CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) CAND1 KIAA0829 TIP120 TIP120A Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; ubiquitin ligase complex [GO:0000151] TBP-class protein binding [GO:0017025] ALTLIAGSPLK;AVAALLTIPEAEK;EGPAVVGQFIQDVK;IDLRPVLGEGVPILASFLRKNQR;LDDDSERK;LDIFEFLNHVEDGLK;LGTLSALDILIK;LTLIDPETLLPR;LTTVKALTLIAGSPLK;VYPSSLSKISGSILNELIGLVR 10 11 0 5.0004 9.66361 0 0 5.30681 3.53543 7.33807 0 7.44394 7.60984 11.6095 9.65449 10.8677 Q86VQ0 LCA5_HUMAN Lebercilin (Leber congenital amaurosis 5 protein) LCA5 C6orf152 Homo sapiens (Human) intraciliary transport [GO:0042073]; photoreceptor cell maintenance [GO:0045494]; protein transport [GO:0015031] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; photoreceptor connecting cilium [GO:0032391] protein-containing complex binding [GO:0044877] DTDLVTKR;SQEKERATEK;WEEPGHLTLDLQSQK;YQLGMYPIQNMDK 4 6.6 0.97774 -2.1337 8.96428 0 0 0 0 0 0 0 0 0 8.46291 0 Q86VQ1 GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein GLCCI1 Homo sapiens (Human) cytoplasm [GO:0005737] DKDSGSSSPLPK 1 2.2 0.97954 -1.546 0 0 9.03353 0 0 0 0 0 0 0 0 0 Q86VQ3 TXND2_HUMAN Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) TXNDC2 SPTRX SPTRX1 Homo sapiens (Human) cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] EDFEASLK 1 1.4 0.93674 -0.53914 0 0 0 0 0 0 0 0 11.5046 0 0 0 Q86VR2 RETR3_HUMAN Reticulophagy regulator 3 RETREG3 FAM134C Homo sapiens (Human) collagen catabolic process [GO:0030574]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of neuron projection development [GO:0010976]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; protein-containing complex [GO:0032991] endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] LVFLLAFGLMIIVCIDQWKNK 1 4.5 0.82543 -0.021489 0 0 10.9475 0 0 0 0 0 0 0 0 0 Q86VR2 RETR3_HUMAN Reticulophagy regulator 3 RETREG3 FAM134C Homo sapiens (Human) collagen catabolic process [GO:0030574]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of neuron projection development [GO:0010976]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; protein-containing complex [GO:0032991] endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] MLVTVMMWPLAVYHRLWDR 1 7 0.91836 -0.43632 0 0 0 0 0 0 0 0 0 0 7.1298 0 Q86VR7 VS10L_HUMAN V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein) VSIG10L Homo sapiens (Human) membrane [GO:0016020]; nucleoplasm [GO:0005654] DNPQALPLFLLLASLVGILTLR 1 2.5 0.67753 0.1655 0 0 9.39896 0 0 0 0 0 0 0 0 0 Q86VS3 IQCH_HUMAN IQ domain-containing protein H (Testis development protein NYD-SP5) IQCH Homo sapiens (Human) AKHLAANWNR;KIPTVATFTIPR;LTKFSPEEK 3 3 0.95637 -0.99131 0 8.58376 0 0 0 0 0 0 0 9.78705 0 0 Q86VS8 HOOK3_HUMAN Protein Hook homolog 3 (h-hook3) (hHK3) HOOK3 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi localization [GO:0051645]; interkinetic nuclear migration [GO:0022027]; lysosome organization [GO:0007040]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; FHF complex [GO:0070695]; microtubule [GO:0005874]; pericentriolar material [GO:0000242] dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; dynein light chain binding [GO:0045503]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] DDYRIRCEELEK;ISNLKKILK;QMEERYK 3 3.9 0.98029 -1.6425 7.21412 0 8.52701 0 0 0 0 0 4.08279 0 0 0 Q86VU5 CMTD1_HUMAN Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-) COMTD1 UNQ766/PRO1558 Homo sapiens (Human) methylation [GO:0032259] membrane [GO:0016020]; mitochondrion [GO:0005739] O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] CLQLLRPGGILAVLRVLWR 1 7.3 0.82937 -0.022038 0 0 0 0 7.57954 9.72862 0 0 0 0 0 0 Q86VV8 RTTN_HUMAN Rotatin RTTN Homo sapiens (Human) centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] DPGFFSNK;LAFGDGK;LLLVKKPSVRSLALK;NRLNFHRDPGFFSNK;SFSYHQHFPLIKEIISICSK;TAVRQQLQK 6 3 0.97568 -1.4719 9.97312 7.18547 0 0 7.42936 0 6.63517 9.22335 6.90941 10.2968 6.6761 0 Q86VV8 RTTN_HUMAN Rotatin RTTN Homo sapiens (Human) centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] DPGFFSNK;LAFGDGK;NRLNFHRDPGFFSNK;SFSYHQHFPLIKEIISICSK;SFSYHQHFPLIKEIISICSKM 5 7.2 0.9633 -1.0972 0 0 0 8.80594 0 0 0 0 0 0 0 0 Q86VW0 SESD1_HUMAN SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo) SESTD1 SOLO Homo sapiens (Human) negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878] intermediate filament cytoskeleton [GO:0045111] "phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" LVFEKFTK;QFTIASEERVHR;SLQQQLSDVCYR;VTHFCFWKEKDR;VWKQFTIASEER 5 6.8 0.97813 -2.152 0 0 0 0 8.77146 6.75355 9.97327 0 11.1617 0 7.73498 0 Q86VW1 S22AG_HUMAN Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6) SLC22A16 OCT6 Homo sapiens (Human) acid secretion [GO:0046717]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; spermidine transmembrane transport [GO:1903711] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; organic cation transmembrane transporter activity [GO:0015101]; spermidine transmembrane transporter activity [GO:0015606] LATTWEEAAK 1 1.7 0.92139 -0.44661 0 0 0 0 0 0 10.7795 0 10.5188 0 0 0 Q86VW2 ARHGP_HUMAN Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) ARHGEF25 GEFT Homo sapiens (Human) axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] guanyl-nucleotide exchange factor activity [GO:0005085] GGHKGGR;GRDRIVFGNIQQIYEWHR;LQLNDLLIKPVQRIMK;VFLFEQIIIFSEALGGGVR;YQLLLKDFLKYYNR 5 12.8 0.74121 0.10658 0 0 0 0 0 9.75121 0 0 0 0 0 0 Q86VW2 ARHGP_HUMAN Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) ARHGEF25 GEFT Homo sapiens (Human) axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] guanyl-nucleotide exchange factor activity [GO:0005085] GRDRIVFGNIQQIYEWHR;ILGVMGGMLR;LQLNDLLIKPVQRIMK;VFLFEQIIIFSEALGGGVR;YQLLLKDFLKYYNR 5 12.4 0.81107 -0.014318 0 0 5.42844 0 0 5.87246 0 0 7.34722 0 11.5668 0 Q86VX2 COMD7_HUMAN COMM domain-containing protein 7 COMMD7 C20orf92 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasmic vesicle [GO:0031410] NF-kappaB binding [GO:0051059] SIVKSLLLVPNGALKK;VGSIFLQLKLVVKK 2 15 0.8831 -0.17334 4.29536 0 0 3.69321 0 0 0 0 0 0 0 3.76829 Q86VX9 MON1A_HUMAN Vacuolar fusion protein MON1 homolog A MON1A SAND1 Homo sapiens (Human) protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Mon1-Ccz1 complex [GO:0035658] guanyl-nucleotide exchange factor activity [GO:0005085] ERCLRCGHVCVR;GAHLALR;LLGLYQYLHSR 3 4.6 0.94135 -0.6137 0 0 0 0 0 0 0 5.82561 10.1005 0 0 0 Q86VX9 MON1A_HUMAN Vacuolar fusion protein MON1 homolog A MON1A SAND1 Homo sapiens (Human) protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Mon1-Ccz1 complex [GO:0035658] guanyl-nucleotide exchange factor activity [GO:0005085] GAHLALR;SSGLFTR 2 4.7 0.94087 -0.58797 0 0 0 0 0 0 0 0 0 0 0 12.6392 Q86VY9 T200A_HUMAN Transmembrane protein 200A TMEM200A KIAA1913 HBE61 Homo sapiens (Human) membrane [GO:0016020] IKEQRQMNGMYTGLMGETEVK;NNSIGESLSSQYK;NNSKGYMK 3 8.6 0.98083 -1.7401 0 0 0 0 0 0 0 0 0 0 0 6.57963 Q86VZ4 LRP11_HUMAN Low-density lipoprotein receptor-related protein 11 (LRP-11) LRP11 Homo sapiens (Human) multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414] plasma membrane [GO:0005886] phosphoprotein binding [GO:0051219] RQLQQERPQEELELELR 1 3.4 0.64041 0.17331 5.50643 0 0 7.82972 0 0 0 0 0 0 0 0 Q86VZ5 SMS1_HUMAN Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23) SGMS1 MOB SMS1 TMEM23 Homo sapiens (Human) apoptotic process [GO:0006915]; ceramide biosynthetic process [GO:0046513]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188] EVVYWSPK 1 1.9 0.91701 -0.35605 12.4518 0 0 0 0 10.8415 0 0 0 0 0 0 Q86VZ6 JAZF1_HUMAN Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802) JAZF1 TIP27 ZNF802 Homo sapiens (Human) lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] NVNGIKYHAK 1 4.1 0.92188 -0.44509 0 0 11.6476 0 0 0 0 0 0 0 0 0 Q86W24 NAL14_HUMAN "NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)" NLRP14 NALP14 NOD5 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] ATP binding [GO:0005524] AGETQEDQEAVLGDGTEYRNR;DRKLLEHLFDVDVK;LSVTVVFEKK;LSVTVVFEKKILK;SLCEALKHPECK;SLLQSTSYKDPHLTQMKCFLFGLLNEDR 6 8.1 0.96859 -1.3299 0 0 0 4.61883 7.80896 0 0 0 9.97871 0 9.42805 9.68543 Q86W25 NAL13_HUMAN "NACHT, LRR and PYD domains-containing protein 13 (Nucleotide-binding oligomerization domain protein 14)" NLRP13 NALP13 NOD14 Homo sapiens (Human) regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] ATP binding [GO:0005524] FSYVFYLSCHKIR;ILHSLLKKELVPLATLLITIK;KELVPLATLLITIK;SLTHLNLSKNSLRDEGVK;YRENMKAELLETWDNISWPK 5 6.9 0.044248 0.50191 0 0 6.54425 0 4.73107 0 0 3.53356 0 10.522 4.97572 6.52034 Q86W26 NAL10_HUMAN "NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)" NLRP10 NALP10 NOD8 PYNOD Homo sapiens (Human) activation of innate immune response [GO:0002218]; adaptive immune response [GO:0002250]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 type immune response [GO:2000318]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924] EQMESMKHNR;NDILYKACQVPGICWVVCSWLQGQMERGK 2 6 0.82955 -0.023918 0 0 0 0 0 0 8.97519 0 0 0 10.1079 0 Q86W28 NALP8_HUMAN "NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)" NLRP8 NALP8 NOD16 PAN4 Homo sapiens (Human) regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] ATP binding [GO:0005524] IHQAQLEGLCHLAADSMWHRK;LLKVIPLLHK;VLRSPRCR;VPVVCWMVCSGLK 4 5 0.91003 -0.29838 0 0 12.2568 3.46349 0 10.5858 9.20205 0 0 0 0 0 Q86W33 TPRA1_HUMAN Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (Transmembrane protein 227) TPRA1 GPR175 TMEM227 PP6566 Homo sapiens (Human) embryonic cleavage [GO:0040016]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of mitotic cell cycle phase transition [GO:1901991] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CLLLLYEDIGTSR;LGAQDPLLLQMPSGRDR;SAHLRGFPPGLLR 3 14.7 0.95249 -0.7731 0 8.20945 0 10.1699 0 8.72887 0 0 0 0 9.60777 0 Q86W34 AMZ2_HUMAN Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 BM-014 Homo sapiens (Human) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] RSIYIQSIGDILKFLK 1 5.3 0.85295 -0.079962 0 0 0 0 0 0 0 0 7.10497 5.234 0 0 Q86W42 THOC6_HUMAN THO complex subunit 6 (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) THOC6 WDR58 PSEC0006 Homo sapiens (Human) apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] RNA binding [GO:0003723] ELWRRQPPYR;HLLSAGDGEVK 2 6.2 0.8825 -0.17555 12.2406 0 0 0 0 0 0 10.4712 0 0 0 9.87321 Q86W50 MET16_HUMAN RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) METTL16 METT10D Homo sapiens (Human) "mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; negative regulation of 3'-UTR-mediated mRNA stabilization [GO:1905869]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of mRNA splicing, via spliceosome [GO:0048024]; rRNA base methylation [GO:0070475]; S-adenosylmethionine biosynthetic process [GO:0006556]; snRNA (adenine-N6)-methylation [GO:0120049]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA m(6)A methyltransferase activity [GO:0001734]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; U6 snRNA (adenine-(43)-N(6))-methyltransferase activity [GO:0120048]; U6 snRNA 3'-end binding [GO:0030629] ALTCTLLR;EGEAAAVEGPCPSQESLSQEENPEPTEDER;GVNSRNPR;KNVEQNNLSDLIK;LEKPRKPITFVVLASVMK;SETAEGIVVVTTWIEKILTDLKVQHK 6 18.3 0.95437 -0.95936 0 3.93007 0 0 0 0 9.17607 0 0 7.8591 10.9578 0 Q86W54 SPA24_HUMAN Spermatogenesis-associated protein 24 (Testis protein T6441 homolog) SPATA24 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] ENEIKELQQVISQQK 1 7.3 0.91668 -0.42883 0 11.8912 0 0 0 0 0 0 0 0 0 0 Q86W56 PARG_HUMAN Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Homo sapiens (Human) "ATP generation from poly-ADP-D-ribose [GO:1990966]; base-excision repair, gap-filling [GO:0006287]; carbohydrate metabolic process [GO:0005975]; nucleotide-sugar metabolic process [GO:0009225]; regulation of DNA repair [GO:0006282]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] poly(ADP-ribose) glycohydrolase activity [GO:0004649] LKTLFCYFR;LPGNISSLNVECR;RMPRCGIR;SHEDGSERDDWQR;TERKIPK;TLFCYFR;WLGTPIEEMRR;WLGTPIEEMRRMPR;YLDQFVPEKMR;YVPPHLSPDKKWLGTPIEEMR 10 8.4 0.97462 -3.862 0 6.04922 9.36089 9.97785 0 8.29103 0 11.0076 8.54578 8.24603 9.88073 0 Q86W67 F228A_HUMAN Protein FAM228A FAM228A C2orf84 Homo sapiens (Human) TGLQCETGK 1 4.4 0.90972 -0.31574 7.0387 0 9.25967 0 0 0 0 0 0 0 0 0 Q86W74 ANR46_HUMAN Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S) ANKRD46 Homo sapiens (Human) membrane [GO:0016020] VLLLIFVIALLSLGIAYYRR;VLLLIFVIALLSLGIAYYRRTLR 2 9.9 0.067881 0.4279 0 0 0 0 0 0 0 8.86279 0 0 6.31375 0 Q86W92 LIPB1_HUMAN Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) PPFIBP1 KIAA1230 Homo sapiens (Human) cell adhesion [GO:0007155]; cortical microtubule organization [GO:0043622]; neuromuscular junction development [GO:0007528] cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] cadherin binding [GO:0045296] DLEFCLEEHREK;LTPKPETSFEENDGNIILGATVDTQLCDK;MKGEGVEIVDRDIEVQK;WTNHRVMEWLR 4 6.8 0.92387 -0.44971 0 0 0 0 0 0 3.94251 0 0 0 0 0 Q86W92 LIPB1_HUMAN Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) PPFIBP1 KIAA1230 Homo sapiens (Human) cell adhesion [GO:0007155]; cortical microtubule organization [GO:0043622]; neuromuscular junction development [GO:0007528] cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] cadherin binding [GO:0045296] LTPKPETSFEENDGNIILGATVDTQLCDK;MKGEGVEIVDRDIEVQK;MLQQELLSR;WTNHRVMEWLR 4 7.7 0.97998 -2.0106 12.0858 0 0 0 9.86499 0 0 0 0 0 10.4806 0 Q86WA6 BPHL_HUMAN Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA) BPHL MCNAA Homo sapiens (Human) amino acid metabolic process [GO:0006520]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] alpha-amino-acid esterase activity [GO:0047658] LRLLLSALKPGIHVPR 1 5.5 0.82529 -0.020194 0 0 0 0 0 2.66405 0 0 4.59126 0 0 0 Q86WA8 LONP2_HUMAN "Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon)" LONP2 LONP Homo sapiens (Human) peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; regulation of fatty acid beta-oxidation [GO:0031998]; response to organic cyclic compound [GO:0014070] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252] GLVLPVGGIKDKVLAAHR;TSVDSAR;VLEYLAVRQLKNNLK;YAVQLVEMLDMSVPAVAKLRR 4 7.2 0.97923 -1.5361 0 10.3665 0 8.43671 0 0 0 0 0 0 0 9.86487 Q86WA9 S2611_HUMAN Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) SLC26A11 Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; chloride:bicarbonate antiporter activity [GO:0140900]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116] TLWRVKR 1 1.2 0.97915 -1.5349 0 0 10.3078 0 0 0 0 0 0 0 0 0 Q86WB7 UN93A_HUMAN Protein unc-93 homolog A (HmUnc-93A) (Unc-93A) UNC93A Homo sapiens (Human) membrane [GO:0016020]; plasma membrane [GO:0005886] EAAFANYR 1 1.9 0.93664 -0.52387 9.05463 0 0 0 0 0 0 0 0 0 0 0 Q86WC4 OSTM1_HUMAN Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) OSTM1 GL HSPC019 UNQ6098/PRO21201 Homo sapiens (Human) osteoclast differentiation [GO:0030316]; transepithelial chloride transport [GO:0030321] chloride channel complex [GO:0034707]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] NYSEVCKNCREAYK 1 4.2 0.96565 -1.1228 0 0 0 0 0 0 0 0 0 10.1819 0 0 Q86WC6 PPR27_HUMAN Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin) PPP1R27 DYSFIP1 Homo sapiens (Human) phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864] DATNDDGDLPSDLIDPDYKELVELFK 1 16.9 0.8419 -0.043106 0 7.55827 0 0 0 0 0 0 0 0 0 0 Q86WD7 SPA9_HUMAN Serpin A9 (Centerin) (Germinal center B-cell-expressed transcript 1 protein) SERPINA9 GCET1 SERPINA11 UNQ692/PRO1337 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] WEKPFHPEYTRK 1 2.9 0.6745 0.16713 0 0 0 0 0 10.4129 0 0 0 0 0 0 Q86WG3 ATCAY_HUMAN Caytaxin (Ataxia cayman type protein) (BNIP-2-homology) (BNIP-H) ATCAY KIAA1872 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrion distribution [GO:0048311]; negative regulation of glutamate metabolic process [GO:2000212]; neuron projection development [GO:0031175]; regulation of protein localization [GO:0032880] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; mitochondrial membrane [GO:0031966]; neuron projection [GO:0043005]; presynapse [GO:0098793]; synapse [GO:0045202] kinesin binding [GO:0019894] TVIIGEQEHRIDLHMIRPYMK 1 5.7 0.82604 -0.020249 0 0 0 0 0 0 0 8.74682 0 0 0 0 Q86WG5 MTMRD_HUMAN Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) autophagy [GO:0006914]; myelination [GO:0042552] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; phosphatase regulator activity [GO:0019208]; phosphatidylinositol binding [GO:0035091] AILDHQQFDYIIR;DKLPDDHYQEKTAMDLAAEQLR;IKVEENNPVK;SYPGLLVVPQAVQDSSLPRVARCYR;TLPAALR 5 4.2 0.95219 -0.74159 0 11.8419 12.1273 4.62422 0 0 9.46761 0 0 11.8263 0 8.84665 Q86WH2 RASF3_HUMAN Ras association domain-containing protein 3 RASSF3 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] FLVTESPAK 1 3.8 0.88145 -0.1579 0 0 0 0 0 0 0 11.6116 0 0 0 0 Q86WI1 PKHL1_HUMAN Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) immune response [GO:0006955]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium membrane [GO:0060171]; stereocilium tip [GO:0032426] signaling receptor activity [GO:0038023] CGGWSAK;ISNVEFYHSGQEGFRDSTDPR;LEEILEYNEK;LPALANK;TVYPGGR;YHVPGTGESYTLAADVGILSR 6 1.7 0.95377 -0.9207 0 8.42337 0 6.60609 0 8.7268 8.30218 0 8.85621 8.08034 7.78084 0 Q86WI3 NLRC5_HUMAN Protein NLRC5 (Caterpiller protein 16.1) (CLR16.1) (Nucleotide-binding oligomerization domain protein 27) (Nucleotide-binding oligomerization domain protein 4) NLRC5 NOD27 NOD4 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; regulation of kinase activity [GO:0043549]; response to bacterium [GO:0009617] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] VEEYVNHFFSAQPSR;VILQLNK 2 1.2 0.9168 -0.42869 0 9.06786 0 0 0 0 0 11.0366 0 0 0 0 Q86WN1 FCSD1_HUMAN F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) FCHSD1 UNQ737/PRO1431 Homo sapiens (Human) membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin filament polymerization [GO:0030833] cell projection [GO:0042995]; cuticular plate [GO:0032437]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; recycling endosome [GO:0055037] lipid binding [GO:0008289] EGHRSGEMDSRGR;LAGPFLK;LRFLEQLSILQTWQQREADLLEDIR 3 6.5 0.98067 -1.6446 13.5748 5.36915 13.5361 0 0 0 9.30326 0 0 0 0 11.0972 Q86WN2 IFNE_HUMAN Interferon epsilon (IFN-epsilon) (Interferon epsilon-1) IFNE IFNE1 UNQ360/PRO655 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular space [GO:0005615] cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132] KNFLLPQK;SLSPQQYQK 2 8.2 0.95842 -1.0026 0 0 0 0 0 11.937 0 0 0 11.9929 13.0649 0 Q86WP2 GPBP1_HUMAN Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) GPBP1 GPBP SSH6 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; RNA binding [GO:0003723] ECNRSNSSSPVDK;FGPWKNSTFKPTTENDDTETSSSDTSDDDDV 2 9.3 0.95504 -0.83477 5.3989 0 0 0 0 0 0 0 0 0 0 0 Q86WR0 CCD25_HUMAN Coiled-coil domain-containing protein 25 CCDC25 Homo sapiens (Human) positive regulation of cell motility [GO:2000147] endomembrane system [GO:0012505]; plasma membrane [GO:0005886] DNA binding [GO:0003677] AQIQEMK;LSSAHVYLR 2 7.7 0.88692 -0.19383 9.91283 10.2293 8.52779 10.1808 6.91922 0 0 8.79731 9.66322 7.67807 7.19889 8.51901 Q86WR6 CHCT1_HUMAN CHD1 helical C-terminal domain containing protein 1 CHCT1 C17orf64 Homo sapiens (Human) cytoplasm [GO:0005737] SQDHVKK 1 3 0.78275 0.022191 0 0 7.24432 0 0 0 0 0 0 0 0 0 Q86WR7 PRSR2_HUMAN Proline and serine-rich protein 2 PROSER2 C10orf47 Homo sapiens (Human) AAVSVQER;SDASDMNSDTSPSCR;SSSSRSR 3 6.9 0.97937 -1.8931 0 0 0 0 0 0 9.57769 9.80642 0 5.07433 0 0 Q86WS4 RDIC1_HUMAN Regulator of DNA class I crossover intermediates 1 REDIC1 C12orf40 Homo sapiens (Human) meiotic cell cycle [GO:0051321] chromosome [GO:0005694] DNA binding [GO:0003677]; RNA binding [GO:0003723] CDAGIQTESESVMEEK;CDYDSMGDTCVVTSSDK;KQKEYFEK;LNKSQDVFSPSHK;LNSLGNRNLLTK 5 10.1 0.95639 -0.99328 7.29508 0 0 8.06097 0 0 10.2668 11.762 0 6.54588 5.93213 0 Q86WT6 TRI69_HUMAN E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69) TRIM69 RNF36 HSD-34 HSD34 Homo sapiens (Human) apoptotic process [GO:0006915]; innate immune response [GO:0045087]; protein localization to centrosome [GO:0071539]; protein ubiquitination [GO:0016567] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DILTELR;EAIAAHK;EAIAAHKENKLHLQQHVSMEFLK;LYPYFCPCLNDGGENK 4 9.2 0.90822 -0.27525 0 0 0 0 7.37573 10.3987 0 0 0 0 6.51006 0 Q86WV1 SKAP1_HUMAN Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55) SKAP1 SCAP1 SKAP55 Homo sapiens (Human) adaptive immune response [GO:0002250]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of integrin activation [GO:0033625]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; T cell receptor complex [GO:0042101] protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] GLFYYYANEK 1 2.8 0.80301 0.013335 7.33994 0 0 0 0 0 0 0 0 0 0 0 Q86WV6 STING_HUMAN Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) STING1 ERIS MITA STING TMEM173 Homo sapiens (Human) activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cGAS/STING signaling pathway [GO:0140896]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein complex oligomerization [GO:0051259]; protein localization to endoplasmic reticulum [GO:0070972]; regulation of inflammatory response [GO:0050727]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine/threonine protein kinase complex [GO:1902554]; STING complex [GO:1990231] "2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; proton channel activity [GO:0015252]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]" GLAPAEISAVCEK;MPHSSLHPSIPCPRGHGAQK 2 8.7 0.94484 -0.64538 9.98613 10.1778 0 9.30204 0 0 0 0 0 0 0 0 Q86WW8 COA5_HUMAN Cytochrome c oxidase assembly factor 5 COA5 C2orf64 Homo sapiens (Human) leukocyte differentiation [GO:0002521]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; multicellular organism growth [GO:0035264]; spleen development [GO:0048536]; thymus development [GO:0048538] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] MPKYYEDKPQGGACAGLK 1 24.3 0.91957 -0.43797 0 0 0 0 0 0 0 0 0 8.79867 0 0 Q86WX3 AROS_HUMAN Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) RPS19BP1 AROS Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] enzyme binding [GO:0019899]; RNA binding [GO:0003723] KAEGTVFTEEDFQK;VNLKFLTR 2 16.2 0.98137 -1.7069 0 0 0 0 0 0 0 0 0 10.4482 8.40092 0 Q86WZ0 HEAT4_HUMAN HEAT repeat-containing protein 4 HEATR4 Homo sapiens (Human) oxidoreductase activity [GO:0016491] DPYWKIKAFAIR;GEQGPLTLQTLLQETFQDEMVLPR;LLPSFLHCFSDDFTAVR;LNERTARWIQSK 4 6.3 0.98072 -1.598 13.1687 0 0 0 0 0 0 0 7.46891 11.0872 0 0 Q86X02 CDR2L_HUMAN Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) CDR2L HUMPPA Homo sapiens (Human) Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496] cytoplasm [GO:0005737] identical protein binding [GO:0042802] EIFSRIQKTK;VQELEAELLELQQMKQAK 2 6 0.98156 -1.767 0 0 0 0 0 0 0 0 10.2505 0 0 0 Q86X10 RLGPB_HUMAN Ral GTPase-activating protein subunit beta (p170) RALGAPB KIAA1219 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; Ral protein signal transduction [GO:0032484]; regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] ALGFLVR;LSPSSRMRK;NNEQEVKYK 3 1.7 0.97236 -2.7243 0 0 11.9599 10.5042 7.31642 0 0 0 0 0 0 0 Q86X19 TMM17_HUMAN Transmembrane protein 17 TMEM17 Homo sapiens (Human) cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038] AVFSDSNR;FHLQDFDRLSANR;LSANRGDMR 3 12.6 0.97925 -1.8791 0 0 0 7.71541 0 0 0 0 0 0 11.5156 0 Q86X24 HORM1_HUMAN HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein) HORMAD1 NOHMA Homo sapiens (Human) blastocyst development [GO:0001824]; meiotic cell cycle [GO:0051321]; meiotic DNA double-strand break formation [GO:0042138]; meiotic recombination checkpoint signaling [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] RLLAVSVSCITYLR 1 3.6 0.65378 0.16985 0 0 0 0 0 0 0 0 0 10.9727 0 0 Q86X24 HORM1_HUMAN HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein) HORMAD1 NOHMA Homo sapiens (Human) blastocyst development [GO:0001824]; meiotic cell cycle [GO:0051321]; meiotic DNA double-strand break formation [GO:0042138]; meiotic recombination checkpoint signaling [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] ISRWMLGCYDALQKK 1 4.8 0.84999 -0.079145 0 0 0 0 0 0 0 0 0 7.63481 0 0 Q86X27 RGPS2_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) RALGPS2 Homo sapiens (Human) Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] CHSLGYNFIHKMNTAEFK;FNHVSFWVVR;IEPGTSTPR 3 6.3 0.95641 -0.99401 0 0 0 8.84844 0 0 0 0 0 0 8.24888 0 Q86X29 LSR_HUMAN Lipolysis-stimulated lipoprotein receptor (Angulin-1) LSR ILDR3 LISCH Homo sapiens (Human) epithelial structure maintenance [GO:0010669]; establishment of blood-brain barrier [GO:0060856]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; maintenance of blood-brain barrier [GO:0035633]; protein localization to tricellular tight junction [GO:0061833]; tricellular tight junction assembly [GO:1904274] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; chylomicron [GO:0042627]; extracellular exosome [GO:0070062]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; very-low-density lipoprotein particle [GO:0034361] LLEEAVRK;VLYYMEK 2 2.3 0.95551 -0.94394 0 0 0 0 0 0 0 12.6215 0 0 0 0 Q86X40 LRC28_HUMAN Leucine-rich repeat-containing protein 28 LRRC28 UNQ436/PRO867 Homo sapiens (Human) intracellular signal transduction [GO:0035556] GLPSYLYNK;GLYHTYHSLLK;NLHHFPLELLKDEGLQYLER;NRLWYVPR;TISVARLEKHK;TVFLPAEVK 6 18.5 0.97488 -3.1384 12.3911 9.38265 0 12.9222 0 9.10588 0 7.37877 0 0 0 13.9236 Q86X45 DAA11_HUMAN Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein) DNAAF11 LRRC6 LRTP TSLRP Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; male gonad development [GO:0008584]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; protein localization to cilium [GO:0061512]; protein localization to motile cilium [GO:0120229]; reproductive system development [GO:0061458] apical cytoplasm [GO:0090651]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; motile cilium [GO:0031514] ALNVNEPKIDFSLKDNEK 1 3.9 0.86473 -0.0854 11.3834 0 0 0 0 0 0 0 0 0 0 0 Q86X51 EZHIP_HUMAN EZH inhibitory protein EZHIP CXorf67 Homo sapiens (Human) chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase inhibitor activity [GO:0180000] ITLVASALRRR;SRITLVASALRR 2 2.6 0.98069 -1.6324 0 0 0 0 0 0 0 5.00176 0 0 8.93552 0 Q86X52 CHSS1_HUMAN Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) CHSY1 CHSY CSS1 KIAA0990 UNQ756/PRO1487 Homo sapiens (Human) "bone morphogenesis [GO:0060349]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; response to nutrient levels [GO:0031667]; sulfation [GO:0051923]" extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] EIVLMSKYSNTEIHK;FDMFVRFMGNFEK;MVPHIGKCLR 3 4.7 0.98012 -1.5643 0 0 0 0 9.93409 0 0 0 0 0 0 0 Q86X53 ERIC1_HUMAN Glutamate-rich protein 1 ERICH1 HSPC319 Homo sapiens (Human) AAGLAAK;VISAFFSYWITHILPEK 2 5.4 0.1406 0.3519 11.4166 11.7703 0 0 0 0 0 9.15246 0 0 0 0 Q86X55 CARM1_HUMAN Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) CARM1 PRMT4 Homo sapiens (Human) chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of dendrite development [GO:2000171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; replication fork reversal [GO:0071932]; response to cAMP [GO:0051591] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; DNA-binding transcription factor binding [GO:0140297]; histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor coactivator activity [GO:0030374]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] SVKYTVNFLEAK 1 2 0.9444 -0.62933 12.4159 0 0 0 0 0 0 0 0 0 0 0 Q86X67 NUD13_HUMAN "NAD(P)H pyrophosphatase NUDT13, mitochondrial (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 13) (Nudix motif 13) (Protein KiSS-16)" NUDT13 Homo sapiens (Human) NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; nucleobase-containing small molecule interconversion [GO:0015949] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; NADPH pyrophosphatase activity [GO:0010943]; pyrophosphatase activity [GO:0016462] EDDDACK 1 2 0.71054 0.15906 0 0 0 0 0 0 0 0 0 0 4.88118 0 Q86X76 NIT1_HUMAN Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1) NIT1 Homo sapiens (Human) amide catabolic process [GO:0043605] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] deaminated glutathione amidase activity [GO:0110050] AIETQCYVVAAAQCGR;EAARLGACLAFLPEAFDFIAR 2 11.3 0.91824 -0.40473 0 8.58665 0 0 0 0 7.45951 7.05463 0 0 0 0 Q86X83 COMD2_HUMAN COMM domain-containing protein 2 COMMD2 HSPC042 My004 Homo sapiens (Human) cytoplasm [GO:0005737] IYEGAAR;LHLNQNGDHNTK 2 9.5 0.9528 -0.76893 0 0 0 0 0 0 7.55903 0 0 10.5468 0 0 Q86X95 CIR1_HUMAN Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) CIR1 CIR Homo sapiens (Human) in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; RNA splicing [GO:0008380] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714] SFANFMCKK;SLTTKQKQK 2 4 0.98031 -1.8623 0 13.0008 0 11.5375 0 0 0 0 0 0 0 13.3123 Q86XA9 HTR5A_HUMAN HEAT repeat-containing protein 5A HEATR5A C14orf125 KIAA1316 Homo sapiens (Human) "endocytosis [GO:0006897]; protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endocytic vesicle [GO:0030139] DVEGDSVPKPLPPALSVISSASK;ETDERLCHDIK;LLGIILAKAVISK;MYGSPLKTPSVVYR;RSAEVDDGAAEK;YEIMLSLQNILNGLGAAAAPCHRDVYKAAR;YTKSPGK 7 5.4 0.97442 -3.4974 0 10.7274 7.837 6.67299 10.029 0 0 0 0 0 0 7.1035 Q86XD8 ZFAN4_HUMAN AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) ZFAND4 ANUBL1 Homo sapiens (Human) zinc ion binding [GO:0008270] DITEMTNKASK;KEPPFFNDDNMGPFYYR;LEGIPICR 3 5 0.97946 -1.8789 11.2598 0 0 0 0 0 0 10.1316 0 0 11.0092 0 Q86XE0 SNX32_HUMAN Sorting nexin-32 (Sorting nexin-6B) SNX32 SNX6B Homo sapiens (Human) "protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768] phosphatidylinositol binding [GO:0035091] ALADYENANK;ALADYENANKALDKAR 2 4 0.97627 -1.469 0 0 11.3779 0 0 0 0 0 8.84897 0 0 0 Q86XE3 MICU3_HUMAN "Calcium uptake protein 3, mitochondrial (hMICU3) (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial calcium ion homeostasis [GO:0051560]; positive regulation of neurotransmitter secretion [GO:0001956] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; protein heterodimerization activity [GO:0046982] AVAEAAWR;EFIGIMKDRLHR;RLLWPPPR;SIGQDEFK 4 6.8 0.96417 -1.1656 0 0 0 8.37543 7.43003 0 10.1895 9.94015 0 0 0 0 Q86XE5 HOGA1_HUMAN "4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase) (Protein 569272)" HOGA1 C10orf65 DHDPSL Homo sapiens (Human) 4-hydroxyproline catabolic process [GO:0019470]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; N-acetylneuraminate catabolic process [GO:0019262]; oxalate metabolic process [GO:0033609]; pyruvate biosynthetic process [GO:0042866] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "(4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; (R,S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]; N-acetylneuraminate lyase activity [GO:0008747]; protein homodimerization activity [GO:0042803]" APLQELSPAEEEALR;LIEPNAAVTR 2 15.2 0.92936 -0.47004 0 0 0 10.6221 0 0 0 0 8.8875 0 0 0 Q86XH1 DRC11_HUMAN Dynein regulatory complex protein 11 (IQ and AAA domain-containing protein 1) IQCA1 DRC11 IQCA Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568] EEEESFK;ELQSEIRIQVDELMRQELK;ENLQDQIR;GVLTDQRIR;IQVDELMR;KDKDLTADR;KVTDTWAAALR;TFYKKVPNAEK;YVQIFRNLENVYDQFVHPQK 9 11.4 0.97666 -4.7382 8.78342 0 12.814 9.68984 0 0 0 6.34898 0 0 9.06377 0 Q86XI2 CNDG2_HUMAN Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) NCAPG2 LUZP5 Homo sapiens (Human) cell division [GO:0051301]; chromosome condensation [GO:0030261]; erythrocyte differentiation [GO:0030218]; inner cell mass cell proliferation [GO:0001833]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; transcription by RNA polymerase II [GO:0006366] condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bHLH transcription factor binding [GO:0043425]; methylated histone binding [GO:0035064] DPNLHAIEMDSEIQK;EITGSSLIQK;EPPEDEEEEDGR;LQSSIQDLCVTWWEK;MIHGTIK;VTGELAFDTSSADVR 6 6.5 0.96359 -1.2041 7.48776 0 0 0 0 8.58229 2.04991 0 7.87719 5.39975 0 0 Q86XI6 PPR3B_HUMAN Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) PPP1R3B PPP1R4 Homo sapiens (Human) glycogen metabolic process [GO:0005977]; negative regulation of glycogen catabolic process [GO:0045818]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979] glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164] [phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase regulator activity [GO:0019888] VQNLAFEKTVKIR 1 4.6 0.86533 -0.090261 0 0 0 0 0 0 0 0 12.1968 10.491 10.1331 0 Q86XI8 ZSWM9_HUMAN Uncharacterized protein ZSWIM9 ZSWIM9 C19orf68 Homo sapiens (Human) DMWVRFRAFEAAR;GLETGDWGGAPK;GPEIRDWR;GVAQCLR 4 6.4 0.97254 -2.7812 0 0 0 0 0 9.91974 10.4255 0 0 0 0 0 Q86XJ0 CAHM3_HUMAN Calcium homeostasis modulator protein 3 (Protein A) CALHM3 FAM26A Homo sapiens (Human) ATP export [GO:1904669]; ATP transport [GO:0015867]; protein heterooligomerization [GO:0051291]; sensory perception of taste [GO:0050909] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; voltage-gated monoatomic ion channel activity [GO:0005244] VPCKEDELVR 1 2.9 0.97783 -1.5044 0 0 0 0 0 0 0 0 11.2057 0 0 0 Q86XJ1 GA2L3_HUMAN GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) GAS2L3 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; microtubule cytoskeleton organization [GO:0000226] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] actin binding [GO:0003779]; actin filament binding [GO:0051015]; microtubule binding [GO:0008017] TCNSEESGNFPMR 1 1.9 0.89655 -0.23618 0 0 0 0 0 0 0 0 0 0 4.59054 0 Q86XL3 ANKL2_HUMAN Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; regulation of catalytic activity [GO:0050790] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] protein kinase inhibitor activity [GO:0004860]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888] AGATASK;DPVLTLR;LLNPDDLR;LNLQNIGR;NPRTQDLTAKLR;WKSAVLCYSPSDR 6 5.9 0.97825 -1.5105 13.6338 13.179 13.4954 10.3329 10.4826 6.01433 11.1347 9.70684 11.4822 0 13.4836 11.6615 Q86XN6 ZN761_HUMAN Zinc finger protein 761 ZNF761 KIAA2033 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNECGKTFSHKSSLTCHHR;CNECGKTFSQK;TLYRDVMLENYR;TSSLTCHR 4 8.8 0.89681 -0.24913 0 0 0 0 0 0 0 10.1179 10.1021 0 0 8.37773 Q86XN7 PRSR1_HUMAN Proline and serine-rich protein 1 PROSER1 C13orf23 KIAA2032 Homo sapiens (Human) APHAMISSCGTIPGNPYPKGRPSR 1 2.5 0.83606 -0.034544 0 0 0 0 8.20711 0 0 0 0 0 0 0 Q86XN8 MEX3D_HUMAN RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) MEX3D KIAA2031 RKHD1 RNF193 Homo sapiens (Human) mRNA destabilization [GO:0061157]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723] LELPLSR;TPATQAIR 2 2.3 0.95512 -0.78966 0 0 9.63633 0 0 0 0 0 0 8.0493 0 0 Q86XP0 PA24D_HUMAN Cytosolic phospholipase A2 delta (cPLA2-delta) (EC 3.1.1.4) (Phospholipase A2 group IVD) PLA2G4D Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149] cytosol [GO:0005829]; membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A1 activity [GO:0008970] VLYDISEVLPGKLLRK 1 2 0.41386 0.20034 3.96412 0 0 0 0 0 0 0 0 0 0 0 Q86XP1 DGKH_HUMAN Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) DGKH Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C/protein kinase C signal transduction [GO:0141212]; platelet activation [GO:0030168] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; SAM domain binding [GO:0032093] IVHKNRAQMLTR;LFQKFDNFR 2 1.7 0.91657 -0.34955 0 0 0 0 3.35135 0 0 6.22841 0 0 0 0 Q86XP3 DDX42_HUMAN ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) DDX42 Homo sapiens (Human) protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]; U2-type prespliceosome assembly [GO:1903241] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type prespliceosome [GO:0071004] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] HGGSAGR;LTAMKAAFQSQYK;SIASHVRPDR 3 3.2 0.9643 -1.199 0 0 0 0 0 0 8.37343 0 0 0 0 7.8953 Q86XQ3 CTSR3_HUMAN Cation channel sperm-associated protein 3 (CatSper3) (Ca(v)-like protein) (One-repeat calcium channel-like protein) CATSPER3 Homo sapiens (Human) establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; endoplasmic reticulum [GO:0005783]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] voltage-gated calcium channel activity [GO:0005245] MSQHRHQR;QFTYLYIADGMQSLRILK;QVILQRQQEEISRLMHIQK 3 11.3 0.97472 -2.4019 0 0 0 0 0 5.36236 0 0 0 0 8.30515 0 Q86XR2 NIBA3_HUMAN Protein Niban 3 (B-cell novel protein 1) (Niban-like protein 2) (Protein FAM129C) NIBAN3 BCNP1 FAM129C Homo sapiens (Human) EVDPQLPRVVQTLLR;GPLESCLR;WQPIFCVLR 3 4.6 0.95823 -1.0122 0 0 0 0 0 0 0 0 12.322 9.51094 0 0 Q86XR8 CEP57_HUMAN Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) CEP57 KIAA0092 TSP57 Homo sapiens (Human) fibroblast growth factor receptor signaling pathway [GO:0008543]; protein homooligomerization [GO:0051260]; spermatid development [GO:0007286] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; nucleus [GO:0005634] fibroblast growth factor binding [GO:0017134]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] AIFSALKNLQDKIR;ATPCVPNAR;KTLDEERNSSSR 3 7 0.9371 -0.56701 0 0 0 0 0 0 6.19267 0 0 0 4.6033 0 Q86XS5 ANGL5_HUMAN Angiopoietin-related protein 5 (Angiopoietin-like protein 5) ANGPTL5 UNQ5795/PRO19600 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] EDCEESCDVK;EDCEESCDVKTK 2 3.1 0.92115 -0.44592 0 7.71582 0 0 0 0 0 0 0 0 0 0 Q86XU0 ZN677_HUMAN Zinc finger protein 677 ZNF677 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFTQFANLTRHQK;CNECDKAFAER;ENNKEELYHLVILER;SSNLTNHQR;VCSQNSNLASHQR 5 10.4 0.98047 -2.0354 5.76057 0 0 0 0 0 0 7.44211 0 0 10.2097 0 Q86XX4 FRAS1_HUMAN Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein) FRAS1 KIAA1500 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skin development [GO:0043588] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] ACHSSCLACMGPAPSHCTGCK;CHLCDHGFFLK;NCDSYCLQCQGPHECTR;VEKNVNR 4 1.4 0.95539 -0.828 0 0 0 0 7.15157 0 0 5.83698 0 6.5729 0 8.63786 Q86XZ4 SPAS2_HUMAN Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) SPATS2 SCR59 SPATA10 Nbla00526 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829] RNA binding [GO:0003723] SIDSFGQVSHPK 1 2.2 0.87823 -0.13851 0 0 0 0 0 0 10.8684 0 0 0 0 0 Q86Y01 DTX1_HUMAN E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) DTX1 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription [GO:0006351]; glial cell differentiation [GO:0010001]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of T cell differentiation [GO:0045581]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] Notch binding [GO:0005112]; SH3 domain binding [GO:0017124]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] FTARGFPR;TTSVSAR 2 2.4 0.97857 -1.9851 0 0 0 0 10.3188 0 0 0 0 0 0 0 Q86Y07 VRK2_HUMAN Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) VRK2 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; DNA damage response [GO:0006974]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KQLDYLGIPLFYGSGLTEFK 1 3.9 0.29952 0.25204 0 0 0 0 0 0 9.81721 0 0 0 0 0 Q86Y13 DZIP3_HUMAN E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DFGLLHLEQTEKECLNQLAR;GVVPHIK;ISQFIDPK;SQWEMEK;SSGQLNK 5 4.1 0.98103 -1.7569 0 0 0 0 0 6.44964 10.1473 0 0 0 0 0 Q86Y26 NUTM1_HUMAN NUT family member 1 (Nuclear protein in testis) NUTM1 C15orf55 NUT Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] ALAGGPAPTEK;TPHSGAQLGVPREKPLALGVVRPSQPR 2 3.4 0.94471 -0.6447 0 0 0 0 0 0 0 0 10.0143 0 0 0 Q86Y33 CD20B_HUMAN Cell division cycle protein 20 homolog B CDC20B G6VTS76519 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; de novo centriole assembly [GO:0097742]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786] anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; deuterosome [GO:0098536] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757] QAVCALKWSPDGR 1 2.5 0.97946 -1.5461 0 0 0 0 0 0 0 0 0 0 0 11.002 Q86Y33 CD20B_HUMAN Cell division cycle protein 20 homolog B CDC20B G6VTS76519 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; de novo centriole assembly [GO:0097742]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786] anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; deuterosome [GO:0098536] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757] TEEEMLWVLDSVNATYSDFKSNFAKR 1 13.5 0.68267 0.16504 0 0 5.83431 0 0 0 0 0 0 0 0 0 Q86Y34 AGRG3_HUMAN Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) (G-protein coupled receptor PGR26) ADGRG3 GPR97 PGR26 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; regulation of cell migration [GO:0030334] membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] G protein-coupled receptor activity [GO:0004930] ALCFTKCR 1 1.5 0.94157 -0.60099 4.28998 0 0 0 0 0 0 0 0 0 0 0 Q86Y38 XYLT1_HUMAN Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I) XYLT1 XT1 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; embryonic skeletal system development [GO:0048706]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; ossification involved in bone maturation [GO:0043931]; proteoglycan biosynthetic process [GO:0030166] extracellular space [GO:0005615]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158] FQQTARPTFFAR;KLEQQEKGK 2 2.2 0.97901 -1.9713 0 0 0 0 0 0 0 0 0 9.55298 0 0 Q86Y39 NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) NDUFA11 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] VTLNPPGTFLEGVAK 1 6.6 0.84311 -0.052538 0 0 0 0 0 0 0 0 0 11.1178 0 0 Q86Y46 K2C73_HUMAN "Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)" KRT73 K6IRS3 KB36 KRT6IRS3 Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] AGGKGLSGGFSSR;AKLDELEGALQQAK;FASFIDK;FASFIDKVR;LDSELRSVREVVEDYK;LGSASEFRDSQGK;TTAENEFVVLK 7 14.1 0.97464 -3.5449 0 12.1711 0 0 0 0 0 10.6081 10.5983 0 0 10.4797 Q86Y56 DAAF5_HUMAN Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) DNAAF5 HEATR2 Homo sapiens (Human) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293] dynein intermediate chain binding [GO:0045505] ALEEPGPAADPTAFQGPWARLLLPRLLR;LKLFSILSTVLLR;LLLPRLLR;RPVLGCRELVFR 4 6.2 0.97275 -2.6265 7.76699 0 9.45615 0 7.24954 0 0 4.79587 0 0 0 0 Q86Y56 DAAF5_HUMAN Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) DNAAF5 HEATR2 Homo sapiens (Human) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293] dynein intermediate chain binding [GO:0045505] LKLFSILSTVLLR;RLKLFSILSTVLLR 2 6 0.86857 -0.090719 0 0 0 4.43863 0 0 0 0 0 0 0 0 Q86Y78 LYPD6_HUMAN Ly6/PLAUR domain-containing protein 6 LYPD6 UNQ3023/PRO9821 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263] cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] acetylcholine receptor inhibitor activity [GO:0030550] CFTCEKAADNYECNR 1 8.8 0.91953 -0.43771 0 0 0 0 0 0 0 0 4.59036 0 0 0 Q86Y97 KMT5C_HUMAN Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) KMT5C SUV420H2 PP7130 Homo sapiens (Human) DNA repair [GO:0006281]; methylation [GO:0032259]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830] "condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047] VDLRRLAPAPPATPAPAGTPGPILIPK 1 5.8 0.87326 -0.10833 0 0 0 0 0 0 0 0 0 0 3.27784 0 Q86YA3 ZGRF1_HUMAN 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) double-strand break repair [GO:0006302]; recombinational repair [GO:0000725] nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853]; zinc ion binding [GO:0008270] ALSKVDISFYTSLK;DILVNDGNSCFQKR;DVNNILADPENIVTYK;EIIILSCVRTR;EIIILSCVRTRQVGFIDSEK;GACLESLFLK;HLISKDTEAHISEPEDLGK;IPFNQNDKGCIK;LSLLSRTQVPLITLPR;RKFTGFQGPR;TEEIKNVLGGSTCYNYSVK;VAGAIGIVKQNVNK;VLSLNLK;YLIQQEECAEMK 14 8.7 0.97506 -4.0036 3.83198 0 6.9318 0 9.18797 8.35592 9.65982 7.85449 11.6984 11.2215 9.72404 0 Q86YA3 ZGRF1_HUMAN 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) double-strand break repair [GO:0006302]; recombinational repair [GO:0000725] nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853]; zinc ion binding [GO:0008270] DILVNDGNSCFQKR;DVNNILADPENIVTYK;GACLESLFLK;HLISKDTEAHISEPEDLGK;IPFNQNDKGCIK;RKFTGFQGPR;VAGAIGIVKQNVNK;VQWHSHSSLQP;YLIQQEECAEMK 9 12.7 0.9327 -0.50072 0 0 0 0 0 0 9.70125 0 0 0 0 0 Q86YA3 ZGRF1_HUMAN 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) double-strand break repair [GO:0006302]; recombinational repair [GO:0000725] nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853]; zinc ion binding [GO:0008270] EIIILSCVRTR;EIIILSCVRTRQVGFIDSEK;NYSTHLFQMPLFLKLFICFIFIRSSPTIVSNK 3 9.3 0.8703 -0.096008 0 0 0 0 0 0 8.11977 6.75034 0 0 0 0 Q86YB8 ERO1B_HUMAN ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta) ERO1B ERO1LB Homo sapiens (Human) insulin processing [GO:0030070]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]; unfolded protein binding [GO:0051082] ELEDCEQANK;LSTSIRDLQNFKVLLQHSR 2 6.2 0.93338 -0.51457 0 0 0 0 7.6811 0 0 0 0 0 0 0 Q86YC2 PALB2_HUMAN Partner and localizer of BRCA2 PALB2 FANCN Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; inner cell mass cell proliferation [GO:0001833]; mesoderm development [GO:0007498]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; post-anal tail morphogenesis [GO:0036342]; somitogenesis [GO:0001756] DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677] DGMLSLK;EIRALFCSSDDESEKQVLLK;TLARLQR 3 2.9 0.97612 -2.3362 0 10.4617 0 0 0 0 10.8595 10.3497 0 0 0 0 Q86YD1 PTOV1_HUMAN Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) PTOV1 ACID2 PP642 UNQ6127/PRO20092 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] LVQFHFTKDLETLKSLCR;SLCRIMDNGFR 2 6.5 0.89778 -0.25495 0 0 10.7426 0 0 0 0 0 0 0 0 8.62892 Q86YD1 PTOV1_HUMAN Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) PTOV1 ACID2 PP642 UNQ6127/PRO20092 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] LFPHISPCEVRVLMLLYSSKK;LVQFHFTKDLETLKSLCR 2 17.2 0.76601 0.066865 7.02481 0 0 0 0 0 0 0 0 0 0 0 Q86YE8 ZN573_HUMAN Zinc finger protein 573 ZNF573 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGMKHFECK;LFECQECGK;SSHLTAHQSIHADK;VHTGKKPYECK 4 6.8 0.96718 -1.2908 0 0 0 0 0 9.21956 4.61312 9.52237 0 0 8.78532 0 Q86YF9 DZIP1_HUMAN Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1) DZIP1 DZIP DZIP2 KIAA0996 Homo sapiens (Human) ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; germ cell development [GO:0007281]; heart development [GO:0007507]; maintenance of protein location in cell [GO:0032507]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization to cilium [GO:0061512]; protein-containing complex localization to centriolar satellite [GO:0140706]; smoothened signaling pathway [GO:0007224]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] BBSome binding [GO:0062063]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090] AFMNQAFLQSHIQRR;LQEQNELIITQR;MHLRKALK;NVNKPVGGTNVPEMFIK;TLKEECK;VEKMFPHRK 6 7.8 0.973 -2.5012 0 0 0 0 0 0 7.46107 0 11.9449 6.5458 10.9599 0 Q86YG4 NT5D4_HUMAN 5'-nucleotidase domain-containing protein 4 NT5DC4 Homo sapiens (Human) 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] TLEDLEK;TLEDLEKYVK 2 2.3 0.98095 -2.034 0 0 0 10.5161 0 0 0 0 0 0 0 12.6121 Q86YH2 Z280B_HUMAN Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632) ZNF280B SUHW2 ZNF279 ZNF632 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NLLCPFCLKIFK;VTPGSWSRR 2 3.9 0.96228 -1.0796 0 0 0 0 0 9.20841 0 0 0 0 9.63762 0 Q86YI8 PHF13_HUMAN PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1) PHF13 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; regulation of DNA repair [GO:0006282] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] MDSDSCAAAFHPEEYSPSCK;RDSDAPGK 2 9.3 0.94456 -0.63029 6.11476 0 0 0 0 0 0 0 0 0 0 0 Q86YJ5 MARH9_HUMAN E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9) MARCHF9 MARCH9 RNF179 Homo sapiens (Human) protein ubiquitination [GO:0016567] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DGDGDEEEYYGSEPRAR;EPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRTPQCR;VLNYDKTK 3 18.5 0.98002 -1.7159 0 0 0 0 0 6.36578 0 0 7.51128 10.1365 0 0 Q86YJ6 THNS2_HUMAN Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT) THNSL2 Homo sapiens (Human) 2-oxobutyrate biosynthetic process [GO:0046360]; dephosphorylation [GO:0016311]; serine family amino acid catabolic process [GO:0009071] extracellular space [GO:0005615] cytokine activity [GO:0005125]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905] EVVHLSRLR;IGLPIRLVVAVNR 2 5.7 0.90938 -0.27821 0 7.47159 0 0 5.32794 0 0 0 0 0 0 0 Q86YJ7 AN13B_HUMAN Ankyrin repeat domain-containing protein 13B ANKRD13B Homo sapiens (Human) negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] LRDFITLRLPPGFPVK;RLAGIPVLLEKLR;TRTEHLSEQHKGK;YPLHYLVWHNRHRELEK 4 9.4 0.96207 -1.0784 12.1476 0 0 0 10.8117 4.99783 9.87283 0 0 0 0 7.54288 Q86YL5 TDRP_HUMAN Testis development-related protein (Protein INM01) TDRP C8orf42 Homo sapiens (Human) spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleus [GO:0005634] EVTSLFNK;VLLDEPPEEEDGLR 2 11.9 0.93047 -0.47689 0 0 0 10.571 0 0 0 11.2702 0 0 0 0 Q86YL7 PDPN_HUMAN Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)] PDPN GP36 PSEC0003 PSEC0025 Homo sapiens (Human) "actin-mediated cell contraction [GO:0070252]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; lung development [GO:0030324]; lymph node development [GO:0048535]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of platelet aggregation [GO:1901731]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of myofibroblast contraction [GO:1904328]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]" anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge of lamellipodium [GO:0061851]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; tetraspanin-enriched microdomain [GO:0097197] chemokine binding [GO:0019956]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102] FAVRLPR;YKSGLTTLVATSVNSVTGIR 2 11.4 0.90477 -0.27075 0 0 9.07358 9.07957 0 0 0 0 0 0 0 0 Q86YM7 HOME1_HUMAN Homer protein homolog 1 (Homer-1) HOMER1 SYN47 Homo sapiens (Human) "behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of signal transduction [GO:0009967]; protein localization to synapse [GO:0035418]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cation channel activity [GO:2001257]; regulation of dendritic spine maintenance [GO:1902950]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to calcium ion [GO:0051592]; response to nicotine [GO:0035094]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]" apical part of cell [GO:0045177]; axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; Z disc [GO:0030018] G protein-coupled glutamate receptor binding [GO:0035256]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802] GNNAKLTAALLESTANVKQWK 1 5.9 0.50338 0.18869 0 0 0 0 0 0 0 0 0 0 7.22747 0 Q86YN6 PRGC2_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) PPARGC1B PERC PGC1 PGC1B PPARGC1 Homo sapiens (Human) actin filament organization [GO:0007015]; bone trabecula formation [GO:0060346]; cellular response to reactive oxygen species [GO:0034614]; energy homeostasis [GO:0097009]; estrogen receptor signaling pathway [GO:0030520]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of bone resorption [GO:0045780]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; mediator complex [GO:0016592]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AF-2 domain binding [GO:0050682]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] EEEEEWGR;FEVFGEIEECEVLTRNR 2 2.4 0.96515 -1.1368 0 0 0 0 0 0 0 0 0 6.5481 0 0 Q86YQ8 CPNE8_HUMAN Copine-8 (Copine VIII) CPNE8 Homo sapiens (Human) cellular response to calcium ion [GO:0071277] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] LEKPIVGIPGK;VEVSVSCRNLLDR;VEVSVSCRNLLDRDTFSK 3 5.1 0.95503 -0.9373 12.6794 0 0 0 0 9.18822 0 0 0 0 6.46135 0 Q86YR5 GPSM1_HUMAN G-protein-signaling modulator 1 (Activator of G-protein signaling 3) GPSM1 AGS3 Homo sapiens (Human) cell differentiation [GO:0030154]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of GTPase activity [GO:0034260]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; nervous system development [GO:0007399]; positive regulation of macroautophagy [GO:0016239] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092] YQSSRIDDQRCPPPDVLPR 1 2.8 0.5062 0.18786 0 0 0 0 0 0 0 4.2817 0 0 5.06652 0 Q86YR6 POTED_HUMAN "POTE ankyrin domain family member D (ANKRD26-like family B member 3) (Ankyrin repeat domain-containing protein 21) (Prostate, ovary, testis-expressed protein) (Protein POTE)" POTED A26B3 ANKRD21 POTE Homo sapiens (Human) plasma membrane [GO:0005886] GSGKSNVGAWGDYDHSAFMEPRYHIR;MGKCCRHCFPCCR;WCCHCFPCCR;WCCHCFPCCRGSGK 4 8.4 0.8879 -0.2007 0 0 0 0 0 0 0 0 0 0 0 8.77785 Q86YR7 MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2) MCF2L2 ARHGEF22 DRG KIAA0861 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] DFLFGNIRELYEFHNR;FEVKSEEIFESHHERGNPELEQQAR;GCSSREFSSMDTFEDCEGAEDMEK;GESSQGEKEER;IAVAFPGNLQLIFILRPSRFIQRTFTDIGIK;KWDILGKSLEFHR;LGDLSPR;SIIDGYITPMDFIWLK;SLEFHRQLDK;WDILGKSLEFHR 10 13.2 0.97717 -5.7948 9.40965 3.97664 0 0 4.99923 0 8.75208 0 12.3169 8.88408 10.5566 2.97695 Q86YS3 RFIP4_HUMAN Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) RAB11FIP4 ARFO2 KIAA1821 Homo sapiens (Human) endocytic recycling [GO:0032456]; neural retina development [GO:0003407]; positive regulation of G1 to G0 transition [GO:1903452]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; spindle [GO:0005819] calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] ELEHLQMYK;LDCERPGRGR;LDEERQR;LREVFEVCGRDPDGFLR;LVKYLDPNDLGRINFK;QENTQLVHR;TNVYSDLGSSVSSSAGQTPRKMR 7 14.3 0.9759 -4.5729 0 0 10.907 0 12.0838 0 9.84759 9.50732 0 9.95162 0 0 Q86YS6 RAB43_HUMAN Ras-related protein Rab-43 (Ras-related protein Rab-41) RAB43 RAB41 Homo sapiens (Human) "autophagosome assembly [GO:0000045]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]" endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network membrane [GO:0032588] GTP binding [GO:0005525]; GTPase activity [GO:0003924] QGSTIGVDFTMK 1 5.7 0.8977 -0.23838 0 0 0 0 0 0 0 0 8.64569 0 0 0 Q86YS7 C2CD5_HUMAN C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) C2CD5 CDP138 KIAA0528 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659] cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] ASNEARQR;VDLFNDLNR 2 1.7 0.97842 -2.0827 0 0 0 0 0 0 9.89131 0 9.04977 0 0 0 Q86YT5 S13A5_HUMAN Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5) SLC13A5 NACT Homo sapiens (Human) alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] SFVILFVTPLLLLPLVILMPAK 1 3.9 0.67791 0.1655 0 0 0 0 0 0 0 0 0 0 8.11061 0 Q86YT6 MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) MIB1 DIP1 KIAA1323 ZZANK2 Homo sapiens (Human) blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; neuron differentiation [GO:0030182]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CVQDAKGGSFYRDHCPVLGEQNGNR;EQTMCPVCLDR;QLQDMQDVGK;VLLSKLPRPWIVDEK;VSGQVGSR 5 6.9 0.97968 -1.8432 9.67122 0 0 8.47602 0 0 0 0 9.56508 0 10.1533 0 Q86YT9 JAML_HUMAN Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1) JAML AMICA1 UNQ722/PRO1387 Homo sapiens (Human) gamma-delta T cell activation [GO:0046629]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; monocyte extravasation [GO:0035696]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054] bicellular tight junction [GO:0005923]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803] DEYVLYYYSNLSVPIGR;EEIVFRYYHK 2 6.9 0.97424 -1.3935 0 0 0 0 0 0 0 0 9.94645 0 8.96846 0 Q86YV0 RASL3_HUMAN RAS protein activator like-3 RASAL3 Homo sapiens (Human) negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802] CFSCRSAAER;LSKALWGRHK;SAAERDRWIEDLR;VIQNLANR 4 3.6 0.98127 -1.7029 0 0 6.98014 0 0 7.57531 0 0 0 0 0 10.4857 Q86YV5 PRAG1_HUMAN Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) PRAG1 SGK223 Homo sapiens (Human) cell migration [GO:0016477]; negative regulation of neuron projection development [GO:0010977]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein kinase activity [GO:0004672] AAPVPSK;AKQKPGGTPNLQQKK 2 1.6 0.74839 0.083561 0 0 0 0 0 0 8.62943 0 0 0 6.77952 0 Q86YV6 MYLK4_HUMAN Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085) MYLK4 SGK085 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; myosin light chain kinase activity [GO:0004687]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FLIDTSILPLCLLNCR;QICEGIR;VKCFLEK 3 7.7 0.97847 -1.9347 0 0 0 9.6062 0 0 7.75942 7.89342 0 0 0 0 Q86YV9 HPS6_HUMAN BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru) HPS6 Homo sapiens (Human) blood coagulation [GO:0007596]; intracellular transport [GO:0046907]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lysosome localization [GO:0032418]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein localization to membrane [GO:0072657]; protein secretion [GO:0009306] BLOC-2 complex [GO:0031084]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267] AQLVAGDDEEAGWTELAEQEVAR;LDAHLPLLCR;QLFLVPTATTWPGVAHVLLIWSPGK 3 7.5 0.84065 -0.048015 0 0 0 0 9.92736 0 11.1014 0 0 0 0 0 Q86YW0 PLCZ1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Testis-development protein NYD-SP27)" PLCZ1 Homo sapiens (Human) calcium ion transport [GO:0006816]; egg activation [GO:0007343]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of cytosolic calcium ion concentration involved in egg activation [GO:0060470] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; sperm head [GO:0061827] "calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]" EEIIEIFNTYSENRK;LKIALALSDLVIYTK;MEMRWFLSK;YMDSRECLLFK 4 8.2 0.98041 -1.7224 0 0 12.5062 0 0 0 11.2038 0 0 0 0 10.5972 Q86YW5 TRML1_HUMAN Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) TREML1 TLT1 UNQ1825/PRO3438 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; innate immune response [GO:0045087]; platelet activation [GO:0030168]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091] MGLTLLLLLLLGLEEEEEETHK 1 11 0.67829 0.1655 0 0 0 0 0 0 5.56834 0 0 0 0 0 Q86YW7 GPHB5_HUMAN Glycoprotein hormone beta-5 (Thyrostimulin subunit beta) GPHB5 GPB5 ZLUT1 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of thyroid hormone receptor signaling pathway [GO:0002155] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531] CDCGACSTATTECETI;TFVGCAVR 2 18.5 0.89309 -0.21966 0 0 0 0 0 0 0 0 0 0 9.0558 4.59371 Q86YW9 MD12L_HUMAN Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like) MED12L KIAA1635 TNRC11L TRALP TRALPUSH PRO0314 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] CGESEVLDEK;EDVFAYLAK;ELGDKRSESIDK;ESISSSSLAGSSLPVFQNVLLR;GVWLVAPLIARLPTSVQGR;ILQNLEQWTLR;LAFHMFQEGMLEK;LLLHLFR;LLLHLFRAPQACFLPQATGKPFPGIRSSCDR;QAEIEAER 10 6.3 0.97207 -2.797 13.2166 0 8.16707 10.0534 0 10.1449 0 3.33671 6.59585 11.6221 11.0849 9.56234 Q86YZ3 HORN_HUMAN Hornerin HRNR S100A18 Homo sapiens (Human) cell envelope organization [GO:0043163]; establishment of skin barrier [GO:0061436]; keratinization [GO:0031424] azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] HGSGSGR 1 2.2 0.71065 0.15777 0 0 0 0 6.46009 0 0 0 0 0 0 0 Q86Z14 KLOTB_HUMAN Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein) KLB Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080] plasma membrane [GO:0005886] "fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" GLFYVDFNSKQKER;LAVIPWGVR;LEYNNPR;LWITINEPNRLSDIYNR;NDTIIDIFNDYATYCFQMFGDR;TEDTTAIYMMKNFLSQVLQAIR 6 8.7 0.96614 -1.1303 0 11.424 7.63967 0 0 8.82305 0 0 0 0 7.43871 10.182 Q86Z20 CC125_HUMAN Coiled-coil domain-containing protein 125 (Protein kenae) CCDC125 KENAE Homo sapiens (Human) activation of GTPase activity [GO:0090630]; negative regulation of cell motility [GO:2000146]; negative regulation of Rho protein signal transduction [GO:0035024] cytoplasm [GO:0005737] identical protein binding [GO:0042802] EDGFPSPRSKK 1 2.2 0.9762 -1.4514 0 0 0 0 0 0 0 0 0 10.1628 0 0 Q86Z23 C1QL4_HUMAN Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] collagen trimer [GO:0005581]; extracellular space [GO:0005615] identical protein binding [GO:0042802] VLLLLVAIPLLVHSSR 1 6.7 0.78324 0.026372 0 0 0 0 0 0 0 5.71293 0 0 4.80157 0 Q8HWS3 RFX6_HUMAN DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) RFX6 RFXDC1 Homo sapiens (Human) endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" GEDPELPGAVK;LEPACAATFGK;SEMHLNNGNFSSEEEDADNHDSK;TGTLLPEFPSAQHLVYQGCISKDK;TIRQKFPLLTTR 5 8.7 0.96558 -1.1455 7.10591 0 10.8659 0 0 0 0 10.367 0 0 0 0 Q8IU54 IFNL1_HUMAN Interferon lambda-1 (IFN-lambda-1) (Cytokine Zcyto21) (Interleukin-29) (IL-29) IFNL1 IL29 ZCYTO21 Homo sapiens (Human) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of memory T cell differentiation [GO:0043381]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immune response [GO:0050778]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; type III interferon-mediated signaling pathway [GO:0038196] extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-28 receptor complex [GO:0032002] cytokine activity [GO:0005125]; interleukin-28 receptor binding [GO:0032003]; signaling receptor binding [GO:0005102] LLTRDLKYVADGNLCLR 1 8.5 0.85071 -0.074569 0 0 0 0 0 0 0 0 0 0 0 10.3293 Q8IU57 INLR1_HUMAN Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2) IFNLR1 IL28RA LICR2 Homo sapiens (Human) cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; mucosal immune response [GO:0002385]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cellular respiration [GO:1901857]; regulation of defense response to virus by host [GO:0050691]; response to type III interferon [GO:0034342]; type III interferon-mediated signaling pathway [GO:0038196] interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896] TVSPSSK 1 1.3 0.90942 -0.3105 0 0 0 0 8.51582 0 0 8.69995 8.97573 0 0 0 Q8IU60 DCP2_HUMAN m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) DCP2 NUDT20 Homo sapiens (Human) "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA stability [GO:0043488]; regulation of telomerase RNA localization to Cajal body [GO:1904872]" cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442] "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; 5'-3' RNA exonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; telomerase RNA binding [GO:0070034]" NIEWFSIEKLPCHR;VLDEWKEYK 2 5.5 0.96726 -1.2902 10.1162 0 0 0 0 0 0 0 0 0 0 0 Q8IU80 TMPS6_HUMAN Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) TMPRSS6 UNQ354/PRO618 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; intracellular iron ion homeostasis [GO:0006879]; membrane protein proteolysis [GO:0033619]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; self proteolysis [GO:0097264] extracellular space [GO:0005615]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252] AEVMVSQVYSGSLR;HFSQDLTRR;LLLFHSKR;SETAKAQKMLK;VWQNSRWPGEVSFK 5 6.9 0.96483 -1.1403 0 0 0 0 0 8.68577 8.93484 0 0 0 9.81841 0 Q8IU81 I2BP1_HUMAN Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) IRF2BP1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] AEEWHGRPKAVR;IELLIDAARQLK;YDRATSSGR 3 5.7 0.9782 -2.1297 0 12.1587 0 0 0 0 0 2.40398 0 0 0 0 Q8IU89 CERS3_HUMAN Ceramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297) CERS3 LASS3 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] FWLPPTIK;KCNLTERQVER;SIQDVRSDDEDYEEEEEEEEEEATK 3 11.5 0.98063 -1.6208 9.86723 0 0 0 0 0 0 11.607 0 0 0 0 Q8IUA0 WFDC8_HUMAN WAP four-disulfide core domain protein 8 (Putative protease inhibitor WAP8) WFDC8 C20orf170 WAP8 Homo sapiens (Human) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] CCSHCGLKCMDPR;MWTVRTEGGHFPLHSPTFSWR 2 14.1 0.95144 -0.68582 0 0 0 0 7.55497 10.3329 0 0 0 0 0 0 Q8IUA7 ABCA9_HUMAN ATP-binding cassette sub-family A member 9 (EC 7.6.2.-) ABCA9 Homo sapiens (Human) lipid transport [GO:0006869] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] DYLLEMK;ERKSLWTILLLFGISFIPQLLEHLFYESYQK;TLSEGIKRK;TVNAMAVR 4 3.4 0.90915 -0.31618 0 0 7.49617 0 0 0 0 11.1105 0 0 0 0 Q8IUB2 WFDC3_HUMAN WAP four-disulfide core domain protein 3 (Putative protease inhibitor WAP14) WFDC3 WAP14 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ALLALGSLESWITAGEHAK;CCTTGCGR 2 11.7 0.91684 -0.36267 0 0 0 7.73152 5.49307 0 0 0 0 0 0 0 Q8IUB3 WF10B_HUMAN Protein WFDC10B WFDC10B WAP12 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] DKMRMQR 1 9.6 0.97402 -1.4231 0 0 0 0 0 0 0 0 0 0 8.15259 0 Q8IUB3 WF10B_HUMAN Protein WFDC10B WFDC10B WAP12 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ASKSVGQILLWDFGYTCR 1 20.2 0.88074 -0.16923 0 0 0 0 0 0 0 10.1358 0 0 0 0 Q8IUB9 KR191_HUMAN Keratin-associated protein 19-1 (High tyrosine-glycine keratin-associated protein 19.1) KRTAP19-1 KAP19.1 KRTAP19.1 Homo sapiens (Human) cytosol [GO:0005829]; intermediate filament [GO:0005882] SHYGSYYGGLGYSCGGFGGLGYGYGCGCGSFCR 1 36.7 0.79423 0.015688 0 0 0 0 0 0 0 0 0 0 11.0677 0 Q8IUC6 TCAM1_HUMAN "TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)" TICAM1 PRVTIRB TRIF Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; B cell proliferation [GO:0042100]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of protein-containing complex assembly [GO:0043254]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] autophagosome [GO:0005776]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342] molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591] SPHGPSK;TLSSRDDHR 2 2.2 0.97363 -1.4049 0 0 0 0 0 9.88032 0 0 0 0 7.89257 0 Q8IUC8 GLT13_HUMAN Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] HVNSNQCLDEPSEEDK;SQQWLLRNMTLGT;VDYGDVSVR;YYSLGEIR 4 8.3 0.96534 -1.1578 0 0 11.0709 6.46359 0 0 0 0 0 0 0 8.18795 Q8IUD2 RB6I2_HUMAN ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) ERC1 ELKS KIAA1081 RAB6IP2 Homo sapiens (Human) "I-kappaB phosphorylation [GO:0007252]; maintenance of presynaptic active zone structure [GO:0048790]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031]; regulation of DNA-templated transcription [GO:0006355]; retrograde transport, endosome to Golgi [GO:0042147]" anchoring junction [GO:0070161]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; podosome [GO:0002102]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] cadherin binding [GO:0045296]; PDZ domain binding [GO:0030165]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882] DLKEKVSLLQGDLSEK;EVENEKNDKDK;IAELESLTSR;IEELEEALR;KIENLQEQLR;QAKELFLLRK;QEEIDNYKKDLK;VANLKHKEQVEK;YKDESSKAQAEVDR 9 10.5 0.9749 -2.3766 11.8946 7.77762 0 0 0 0 0 0 11.3108 10.6077 0 0 Q8IUE1 TF2LX_HUMAN "Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X)" TGIF2LX TGIFLX Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ILRDWMYKHR;QMLSEKTNLSLLQISNWFINARR 2 13.7 0.97879 -2.095 0 12.0675 0 0 0 0 0 0 0 0 0 11.782 Q8IUE6 H2A2B_HUMAN Histone H2A type 2-B (H2A-clustered histone 21) H2AC21 HIST2H2AB Homo sapiens (Human) heterochromatin formation [GO:0031507] extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGLQFPVGR;KGNYAER;LLGGVTIAQGGVLPNIQAVLLPK;NDEELNK;TRIIPRHLQLAVR 5 45.4 0.86916 -0.094995 0 0 7.08076 0 0 0 0 0 0 0 0 0 Q8IUF8 RIOX2_HUMAN Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) RIOX2 MDIG MINA MINA53 NO52 Homo sapiens (Human) ribosome biogenesis [GO:0042254] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K4 demethylase activity [GO:0032453]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-histidine dioxygenase activity [GO:0036139]; transcription corepressor activity [GO:0003714] MVYIYHSLKNSR;NSRETHMMGNEEETEFHGLR 2 6.2 0.96362 -1.107 0 9.65567 0 7.89694 7.75782 0 0 0 0 9.26313 0 0 Q8IUG5 MY18B_HUMAN Unconventional myosin-XVIIIb MYO18B Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; in utero embryonic development [GO:0001701]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; nucleus [GO:0005634]; unconventional myosin complex [GO:0016461]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AKPNLSALDAPQVLHQSKR;APCSQIK;DREDQEEELEDVRQSCQK;SLFQARAKLPPVCR;SLVDEQLYR;VLAAIYHLGAAGACKVGR;VQIKRFEVLVIR 7 3.8 0.97535 -3.5913 11.0236 0 4.49787 0 0 10.7278 7.39463 0 0 0 0 3.20817 Q8IUH3 RBM45_HUMAN RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) RBM45 DRB1 DRBP1 Homo sapiens (Human) cell differentiation [GO:0030154]; nervous system development [GO:0007399] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; RNA binding [GO:0003723] IFVMIPK 1 1.5 0.91124 -0.32419 0 0 0 0 0 0 0 0 0 0 10.3052 0 Q8IUH5 ZDH17_HUMAN Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294 Homo sapiens (Human) "axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]" cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynaptic Golgi apparatus [GO:0150051]; presynaptic membrane [GO:0042734] identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102] AVCPFSTQR 1 4.2 0.9306 -0.48874 0 0 0 10.1906 0 0 0 0 0 0 0 0 Q8IUH8 SPP2C_HUMAN Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) SPPL2C IMP5 Homo sapiens (Human) acrosome assembly [GO:0001675]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; intracellular calcium ion homeostasis [GO:0006874]; membrane protein proteolysis [GO:0033619]; protein stabilization [GO:0050821]; sperm-egg recognition [GO:0035036] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]" QELSLFWTGQGR 1 1.8 0.89656 -0.23778 0 0 0 9.05685 0 0 0 0 0 0 0 0 Q8IUI4 S29P2_HUMAN Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) SNX29P2 RUNDC2C Homo sapiens (Human) DLNGQSK;SSMLPTMAAGPNSILFAINIDNK 2 12 0.91733 -0.42148 0 8.84646 0 0 0 0 9.11306 0 0 0 0 0 Q8IUK5 PLDX1_HUMAN Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7) PLXDC1 TEM3 TEM7 Homo sapiens (Human) angiogenesis [GO:0001525]; spinal cord development [GO:0021510] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] IELDPSK;RARESPGHVSEPDR;TRVVEDNHSYYVSR 3 7 0.96542 -1.1464 0 0 0 0 6.33394 0 8.8835 0 0 0 0 0 Q8IUL8 CILP2_HUMAN Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2] CILP2 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular space [GO:0005615] EGSSGPR 1 0.6 0.60717 0.17606 0 0 0 0 0 0 0 0 0 0 7.00405 0 Q8IUN9 CLC10_HUMAN C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301) CLEC10A CLECSF13 CLECSF14 HML Homo sapiens (Human) adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; immune response [GO:0006955]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; pattern recognition receptor activity [GO:0038187] TYENFQYLENK 1 3.5 0.89822 -0.23322 0 0 0 6.57965 0 0 0 0 0 0 0 0 Q8IUQ0 CLVS1_HUMAN Clavesin-1 (Cellular retinaldehyde-binding protein-like) (Retinaldehyde-binding protein 1-like 1) (clathrin vesicle-associated Sec14 protein 1) CLVS1 CRALBPL RLBP1L1 Homo sapiens (Human) lysosome organization [GO:0007040] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] "phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" LLAQYFQYR;LTPSILK;QASKLTPSILK;TLLGPDYSDENDYTHTSYNAMHVK 4 12.4 0.98019 -1.6692 0 0 0 0 0 8.66803 0 0 0 0 0 10.3863 Q8IUQ4 SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) SIAH1 HUMSIAH Homo sapiens (Human) amyloid fibril formation [GO:1990000]; anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511] beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GVLFTCLPAAR;LTWEATPR 2 6.1 0.95442 -0.9146 0 0 0 0 0 0 0 0 0 11.5454 0 0 Q8IUR0 TPPC5_HUMAN Trafficking protein particle complex subunit 5 TRAPPC5 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] LAALGRQVGAR;VLGALLFVKGAVWKALFGK 2 16 0.95526 -0.88291 0 0 0 0 0 0 0 0 8.2785 0 0 0 Q8IUR5 TMTC1_HUMAN Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1) TMTC1 ARG99 Homo sapiens (Human) protein O-linked mannosylation [GO:0035269]; RNA processing [GO:0006396] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] ALQLHPQHNRALFNLGNLLK;EAIYHYR;VVTTSAR 3 3.9 0.95534 -0.8063 0 0 0 12.4679 0 0 0 0 0 15.5939 0 11.3919 Q8IUR5 TMTC1_HUMAN Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1) TMTC1 ARG99 Homo sapiens (Human) protein O-linked mannosylation [GO:0035269]; RNA processing [GO:0006396] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] ALQLHPQHNRALFNLGNLLK;EAIYHYR;RAILVLSYVLVILYFR 3 7.5 0.73163 0.12073 0 0 0 0 0 0 0 0 0 0 0 5.82548 Q8IUR7 ARMC8_HUMAN Armadillo repeat-containing protein 8 ARMC8 S863-2 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GID complex [GO:0034657]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151] EVTASSR;TLPCLVRMCSK 2 4.7 0.95858 -1.0104 0 0 0 0 8.87538 0 7.82763 0 0 0 0 0 Q8IUS5 EPHX4_HUMAN Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) EPHX4 ABHD7 EH4 EPHXRP Homo sapiens (Human) membrane [GO:0016020] epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787] MARLRDCLPR 1 2.8 0.96519 -1.2486 0 0 0 0 0 0 0 0 0 0 0 12.1471 Q8IUX4 ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) APOBEC3F Homo sapiens (Human) base conversion or substitution editing [GO:0016553]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; transposable element silencing [GO:0010526] apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] LSQAGAR;MKPHFRNTVER 2 4.8 0.92178 -0.44551 0 0 0 0 0 0 0 0 0 8.47367 0 0 Q8IUX7 AEBP1_HUMAN Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein) AEBP1 ACLP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; regulation of collagen fibril organization [GO:1904026]; regulation of DNA-templated transcription [GO:0006355] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] "calmodulin binding [GO:0005516]; collagen binding [GO:0005518]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metallocarboxypeptidase activity [GO:0004181]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" EYRDGNPRVR;IYPLTWNGSLCMR;SLVQDTR 3 2.6 0.96449 -1.1782 8.43058 0 0 0 7.27761 0 0 0 0 0 0 12.138 Q8IUX8 EGFL6_HUMAN Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein) EGFL6 MAEG PP648 UNQ281/PRO320 Homo sapiens (Human) cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] basement membrane [GO:0005604]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; integrin binding [GO:0005178] NSNNALAWEKTTSEDEKWK 1 3.4 0.85839 -0.081391 0 0 0 0 0 0 0 0 0 0 0 7.63045 Q8IUY3 GRM2A_HUMAN GRAM domain-containing protein 2A GRAMD2A GRAMD2 Homo sapiens (Human) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; regulation of store-operated calcium entry [GO:2001256] endoplasmic reticulum membrane [GO:0005789]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" YNQQYHKLFKDVPLEEVVLK 1 5.6 0.46258 0.19077 0 0 0 0 3.1757 0 0 0 0 0 0 0 Q8IUZ0 LRC49_HUMAN Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4) LRRC49 CSTPP2 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] ISNLENLK;LISILGDAR;LLQHDLERNYSSR;RLVGENTNR 4 5.7 0.9793 -1.5345 0 0 0 0 11.4107 0 0 0 0 0 2.6371 0 Q8IUZ5 AT2L2_HUMAN 5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2) PHYKPL AGXT2L2 PP9286 Homo sapiens (Human) mitochondrial matrix [GO:0005759] identical protein binding [GO:0042802]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] LISSSCRLFFPEDPVK;QRLISSSCRLFFPEDPVK 2 4 0.40927 0.20558 0 0 0 0 0 0 7.88618 0 0 0 0 10.9701 Q8IV01 SYT12_HUMAN Synaptotagmin-12 (Synaptotagmin XII) (SytXII) SYT12 Homo sapiens (Human) long-term synaptic potentiation [GO:0060291]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; spontaneous exocytosis of neurotransmitter [GO:0048792]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149] EEASFESCFMRVSLLPDEQIVGISR 1 5.9 0.83894 -0.039211 0 0 0 0 6.56866 0 0 0 0 0 0 0 Q8IV04 TB10C_HUMAN Carabin (TBC1 domain family member 10C) TBC1D10C Homo sapiens (Human) "B cell activation [GO:0042113]; calcineurin-NFAT signaling cascade [GO:0033173]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of B cell activation [GO:0050869]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GAVRAGPAAGDQGPAGPAAR 1 6.5 0.94425 -0.63074 0 0 0 0 0 0 0 0 0 9.42939 0 0 Q8IV13 CCNJL_HUMAN Cyclin-J-like protein CCNJL Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] ELKLPTFR;MMDEPWWEGRVASDVHCTLR 2 6.4 0.96711 -1.3115 0 0 0 3.697 0 0 6.80529 0 0 0 0 0 Q8IV16 HDBP1_HUMAN Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1) GPIHBP1 HBP1 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; intracellular protein transport [GO:0006886]; positive regulation of chylomicron remnant clearance [GO:0090321]; positive regulation of lipoprotein lipase activity [GO:0051006]; protein import [GO:0017038]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; response to heparin [GO:0071503]; transcytosis [GO:0045056]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; catalytic complex [GO:1902494]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] chylomicron binding [GO:0035478]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle binding [GO:0071813]; protein transporter activity [GO:0140318] VQDPTGKGAGGPR 1 7.1 0.88717 -0.18603 0 0 0 0 0 0 0 0 0 8.39515 0 0 Q8IV32 CCD71_HUMAN Coiled-coil domain-containing protein 71 CCDC71 Homo sapiens (Human) AARAQAK;VARTQPR 2 3 0.93608 -0.52256 0 0 0 0 6.7226 7.40412 0 0 0 0 9.12817 0 Q8IV33 K0825_HUMAN Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) EATLLDFGWR;ILQQEQNER;NLHTYLSTAVYVFQHFKR;QLLKARK;TSKSSSKHR;YARAHPSRK 6 4.9 0.97948 -1.8459 10.7472 6.98732 7.851 0 0 9.95603 2.53349 10.3588 0 10.2906 0 0 Q8IV35 CF337_HUMAN Cilia- and flagella-associated protein 337 (WD repeat-containing protein 49) CFAP337 WDR49 Homo sapiens (Human) cilium [GO:0005929] calcium ion binding [GO:0005509] AFESPQPR;DLEFLPVKHKDTIQK;LCFLKARK;NSSHYLTISK 4 3.9 0.97564 -3.4185 0 0 0 9.94761 0 0 9.28605 0 0 0 0 9.91022 Q8IV36 HID1_HUMAN Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) HID1 C17orf28 DMC1 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytoplasmic side of Golgi membrane [GO:0098548]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020] ICIDKGLTDESEILR;SKLPLQTIMRLLQVLVPQVEK 2 4.6 0.89738 -0.25435 0 0 0 0 0 0 9.40378 0 0 0 6.42124 0 Q8IV38 ANKY2_HUMAN Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Homo sapiens (Human) cilium [GO:0005929] enzyme binding [GO:0019899]; metal ion binding [GO:0046872] ESIRKFPYCEATLLQQLVR;LDYYTKPQGLDKEPK 2 7.7 0.89768 -0.24 0 0 0 8.92754 0 0 10.7926 0 0 0 0 0 Q8IV53 DEN1C_HUMAN DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) DENND1C FAM31C Homo sapiens (Human) endocytic recycling [GO:0032456]; endocytosis [GO:0006897] centrosome [GO:0005813]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981] APALPSR;GGGALLHSVK 2 2.1 0.95567 -0.87429 0 0 0 0 0 8.88163 0 0 0 0 8.42773 0 Q8IV56 PRR15_HUMAN Proline-rich protein 15 PRR15 Homo sapiens (Human) SLTNSRK 1 5.4 0.93063 -0.47762 0 0 0 0 0 9.69201 0 0 0 0 0 0 Q8IV61 GRP3_HUMAN Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) RASGRP3 GRP3 KIAA0846 Homo sapiens (Human) MAPK cascade [GO:0000165]; Ras protein signal transduction [GO:0007265]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor complex [GO:0032045]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; small GTPase binding [GO:0031267] DLLVLACRRFAR;LLCMYRNATGESCNEFRLK 2 4.5 0.88248 -0.17543 0 0 0 8.08958 8.55386 0 0 0 0 0 0 0 Q8IV63 VRK3_HUMAN Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) VRK3 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674] LFNEQNFFQRAAKPLQVNK;TSCSPQKTR 2 5.9 0.97289 -2.9177 0 0 0 0 0 0 0 0 10.1685 0 0 0 Q8IV76 PASD1_HUMAN Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1) PASD1 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] CLOCK-BMAL transcription complex [GO:1990513]; Cry-Per complex [GO:1990512]; nuclear speck [GO:0016607]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; transcription regulator inhibitor activity [GO:0140416] LQEQKMQEK;VNPKSSQR 2 2.2 0.97791 -1.5049 0 0 0 0 0 0 10.7312 9.64717 9.93537 0 0 0 Q8IV77 CNGA4_HUMAN Cyclic nucleotide-gated channel alpha-4 (CNG channel alpha-4) (CNGa4) (Olfactory cyclic nucleotide-gated channel subunit 2) (OCNC2) CNGA4 Homo sapiens (Human) calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814] ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] TWSFFLDLASLMPTDVVYVRLGPHTPTLRLNR 1 5.6 0.95768 -1.0176 0 0 8.62968 0 0 0 0 0 0 0 0 0 Q8IVC4 ZN584_HUMAN Zinc finger protein 584 ZNF584 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FFKYNNSFILHQR 1 3.1 0.92197 -0.44674 0 0 0 0 0 0 0 0 0 0 9.58084 0 Q8IVE3 PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2 PLEKHH2 KIAA2028 Homo sapiens (Human) negative regulation of actin filament depolymerization [GO:0030835] cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin binding [GO:0003779] DGCSEEQLR;IIEEKAAKIK;KLYSWQQEAQWK;SCDSDEDYEASGR;SGPGSPRAMK;SSSRTSESDSR;WMALRGHSAADCVRIYLTVAR 7 5.8 0.97535 -3.5896 13.5942 10.9824 13.2989 13.4057 10.2304 10.1609 9.29653 13.3987 13.0582 0 0 0 Q8IVF1 NTM2A_HUMAN NUT family member 2A NUTM2A FAM22A KIAA2020 Homo sapiens (Human) LDSSSSK;RPLFGSLSPAEK 2 2.2 0.93611 -0.52712 0 0 0 0 0 0 0 0 0 8.87949 3.07331 0 Q8IVF2 AHNK2_HUMAN Protein AHNAK2 AHNAK2 C14orf78 KIAA2019 Homo sapiens (Human) regulation of RNA splicing [GO:0043484] costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315] GVTAKDSK;KADDESK;LDGAQLEGDLSLADKAVTAK;LEGDLSLAEK;SIEASVDVSEPK;TGSGQGPSSTGQPGR;VDLKGPQIDVNVPK;VEADMSLPSMQGDLK;VEMPSFKMPK;VEMPSLK;VQMPCLK 11 3.4 0.97504 -4.078 0 9.52499 0 9.32771 11.3044 11.8201 0 9.06577 8.79012 6.41139 0 0 Q8IVF4 DYH10_HUMAN Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10) DNAH10 KIAA2017 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVTGDPKR;DVQERYR;ELNCKSIR;IYEDIQDYEAAK;KKYNTVLIIDVHAR;LIAADKLISGLGSENIR;LLDEKTQCNIAQCKR;LQEEAEIMER;NQWVPWSK;NQWVPWSKLVPEYIHAPERK;QAMKNYGR;SKPKVLVVDLPILKIIPIEAHR;TALDIDRLR;YCEDRSR 14 3.5 0.97834 -8.5816 0 0 13.7199 9.24531 10.681 6.44931 13.3236 9.54055 11.4037 7.03023 0 8.95015 Q8IVF5 TIAM2_HUMAN Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) TIAM2 KIAA2016 STEF Homo sapiens (Human) positive regulation of axonogenesis [GO:0050772]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AFVEDTAK;EDTLRLLK;GVAYSTHRTNAPGK;QIPCSLK 4 2.2 0.98019 -1.5633 0 0 0 0 0 0 1.90037 0 0 11.6661 0 10.498 Q8IVF6 AN18A_HUMAN Ankyrin repeat domain-containing protein 18A ANKRD18A KIAA2015 Homo sapiens (Human) AENARLNSELEKEK;DLELVLWRADDVSR;GDAAEVERCLTR;LLQCEKEK;SIRQQILEHK 5 5.8 0.97668 -4.7928 0 3.14976 0 9.51814 0 9.45677 0 0 11.1578 0 0 12.663 Q8IVF7 FMNL3_HUMAN Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) FMNL3 FHOD3 FRL2 KIAA2014 WBP3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267] CHLEPNVR;LPVFNWTALKPNQISGTVFSELDDEK;NFLSTNEGKLDK;NPPHTYIQKLQSFLDPSVTR;YFGESPK 5 7.1 0.97306 -2.8539 5.11931 0 10.8944 9.76807 0 0 0 0 0 0 0 9.9073 Q8IVG5 SAM9L_HUMAN Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739] AFKESQR;ALTNTETATEVDIK;ESQRQTDSKNYETENWSPQK;FPQNAFICQALARHFYIKEK;KEAEEEYGMK;LIQPLTTLKKQLR;SGRNIER;SSRRFLPAR;TEHQKNPK;VSWWNFYFSSENYSSDFVK;YFYIQMQICKDKIWK 11 8.7 0.97497 -4.161 0 6.05065 0 0 6.59008 9.31515 9.39902 9.78418 10.4465 8.24303 8.58946 9.76388 Q8IVH2 FOXP4_HUMAN Forkhead box protein P4 (Fork head-related protein-like A) FOXP4 FKHLA Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAVWTVDEREYQK;QLTLNEIYNWFTRMFAYFR 2 4.7 0.98095 -1.6258 0 0 12.7304 0 0 0 0 0 0 0 0 0 Q8IVH4 MMAA_HUMAN "Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-)" MMAA Homo sapiens (Human) cobalamin metabolic process [GO:0009235] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; protein homodimerization activity [GO:0042803] RSQVWKPK;RSQVWKPKVIR 2 2.6 0.97631 -1.4813 0 0 0 11.2369 0 7.81769 14.2059 0 14.4105 0 0 0 Q8IVH8 M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) MAP4K3 RAB8IPL1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ETEPHHELPDSDGFLDSSEEIYYTAR;HSTLKAKIPPPLPPKPK;IPETKWCQKCCVVR 3 6.4 0.039146 0.51014 0 6.31134 0 0 0 0 0 0 5.89079 0 0 0 Q8IVI9 NOSTN_HUMAN Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477]; endocytosis [GO:0006897]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; endocytic vesicle membrane [GO:0030666]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] KHEALFQLVESSK;KSLDNEVEK;LEKEDENYYQK 3 6.5 0.94449 -0.64069 0 0 0 10.7043 0 0 9.39936 0 0 0 0 0 Q8IVJ8 APRG1_HUMAN APRG1 tumor suppressor candidate (AP20 region protein 1) APRG1 C3orf35 Homo sapiens (Human) membrane [GO:0016020] FSRTYYVK 1 6.7 0.98182 -1.5847 0 0 0 0 8.68678 0 0 0 0 0 0 0 Q8IVL0 NAV3_HUMAN Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) NAV3 KIAA0938 POMFIL1 STEERIN3 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microtubule depolymerization [GO:0007026]; neurogenesis [GO:0022008]; positive regulation of microtubule polymerization [GO:0031116] nuclear outer membrane [GO:0005640] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017] NLSNKKSLLQPK;QNGPVIYKHR;SELREKELK;TIPNLTSRPTPMTWRLGQACPR;TSLDGSQNQDDVVLHVSSK;TVKNIADLR;VWFMDLWNYSLVPYILEAVR 7 4.2 0.9797 -1.8475 11.9126 12.7017 12.7984 0 0 0 13.1362 0 9.53805 0 0 10.8657 Q8IVL1 NAV2_HUMAN Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; heparin binding [GO:0008201]; single-stranded 3'-5' DNA helicase activity [GO:1990518] EGGRHVK;IVVSFQEEMKWK;KQDSDPHLDRNTLPK;LSPKASQVK;QVPIATAENMK;RNPSDVSDESDKSTSGK;SVMLWRWEQNNTTMK;TVKNIADLR;VSAAGSEAK 9 4.3 0.9511 -0.70533 0 0 0 0 0 0 0 9.12335 0 0 0 0 Q8IVL1 NAV2_HUMAN Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; heparin binding [GO:0008201]; single-stranded 3'-5' DNA helicase activity [GO:1990518] EGGRHVK;ESVSESSQQQK;IVVSFQEEMKWK;KPVIHGLEDQK;KQDSDPHLDRNTLPK;LSPKASQVK;QVPIATAENMK;RNPSDVSDESDKSTSGK;TVKNIADLR;VSAAGSEAK 10 4.7 0.97337 -2.9052 0 0 0 11.0249 9.88912 9.61642 13.2609 0 0 12.763 12.7468 0 Q8IVL5 P3H2_HUMAN Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) P3H2 LEPREL1 MLAT4 Homo sapiens (Human) collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-proline hydroxylation [GO:0019511] basement membrane [GO:0005604]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] ELATRPGR;ELELEPGPLQPFDLLYASGAAAYYSGDYER;LGGPASR 3 6.4 0.90181 -0.2627 0 0 10.117 5.69766 0 0 0 0 0 15.1706 0 0 Q8IVL6 P3H3_HUMAN Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) P3H3 LEPREL2 Homo sapiens (Human) collagen biosynthetic process [GO:0032964]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-lysine hydroxylation [GO:0017185] catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] AGTVGSQGAK;EALRSQAALGRVR;QLNGSER;VGSALRDAFR 4 5.4 0.93818 -0.57189 9.67168 7.16662 6.8254 0 0 5.95645 0 0 7.02857 0 10.4506 0 Q8IVL8 CBPO_HUMAN Carboxypeptidase O (CPO) (EC 3.4.17.-) CPO Homo sapiens (Human) proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] SLAQHRQEIVDK 1 3.2 0.9406 -0.58711 0 12.8768 0 0 0 0 0 0 0 0 0 0 Q8IVM0 CCD50_HUMAN Coiled-coil domain-containing protein 50 (Protein Ymer) CCDC50 C3orf6 Homo sapiens (Human) sensory perception of sound [GO:0007605] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase binding [GO:0031625] HFPEFPATR 1 2.9 0.90991 -0.31529 0 0 0 0 0 0 10.4932 0 0 0 0 0 Q8IVM8 S22A9_HUMAN Organic anion transporter 7 (OAT7) (Organic anion/short-chain fatty acid exchanger) (Solute carrier family 22 member 9) SLC22A9 hOAT4 OAT7 UST3 Homo sapiens (Human) hormone transport [GO:0009914]; organic anion transport [GO:0015711]; short-chain fatty acid transmembrane transport [GO:0015913]; sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323] organic anion transmembrane transporter activity [GO:0008514]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] ELEAAQKKKPSLCEMLHMPNICK 1 4.2 0.95497 -0.94569 0 0 0 0 0 0 10.7652 0 0 0 0 0 Q8IVN8 SBSPO_HUMAN Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) SBSPON C8orf84 RPESP Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] FTGDCCFDYDR;GWRLDRVYGTCFCDQACR 2 11 0.17787 0.33881 0 0 0 3.87224 0 0 5.47716 0 0 4.57313 0 9.4476 Q8IVP5 FUND1_HUMAN FUN14 domain-containing protein 1 FUNDC1 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; mitochondrial fusion [GO:0008053]; mitophagy [GO:0000423]; response to hypoxia [GO:0001666] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] VGKLAATAVGGGFLLLQIASHSGYVQIDWKR 1 20 0.66861 0.1687 5.99431 0 0 0 0 0 0 0 0 0 0 0 Q8IVS2 FABD_HUMAN "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)" MCAT MT Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; mitochondrial small ribosomal subunit assembly [GO:0180026] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA binding [GO:0003723] GLGASYR 1 1.8 0.94134 -0.60275 0 0 0 0 11.6796 0 0 0 0 12.1337 0 0 Q8IVS8 GLCTK_HUMAN Glycerate kinase (EC 2.7.1.31) (HBeAg-binding protein 4) GLYCTK HBEBP4 LP5910 Homo sapiens (Human) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glycerate kinase activity [GO:0008887] AAALQVLPRLARAPLHPLLWR 1 4 0.52818 0.18665 0 0 0 0 0 0 0 4.38771 0 0 0 0 Q8IVT2 MISP_HUMAN Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) MISP C19orf21 Homo sapiens (Human) cell division [GO:0051301]; cell migration [GO:0016477]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle assembly [GO:0090307]; organelle localization [GO:0051640]; regulation of protein localization to cell cortex [GO:1904776] actin filament [GO:0005884]; cell cortex [GO:0005938]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; spindle pole centrosome [GO:0031616] actin filament binding [GO:0051015] GLHSENREDEGWQVYR;GVVRWEYFR;IYASEEDD;LDAGDADPR;LSLITAPR 5 7.4 0.97412 -2.4529 16.0954 17.2358 17.3359 14.6771 15.564 13.1958 9.29717 0 16.7391 17.4216 0 11.0701 Q8IVT5 KSR1_HUMAN Kinase suppressor of Ras 1 (EC 2.7.11.1) KSR1 KSR Homo sapiens (Human) positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of MAP kinase activity [GO:0043405] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AAAMGEK;EGRRENQLK;LSHPGHFWK;LVRYICK;SMIFGVK 5 4.2 0.97528 -3.3657 0 9.85265 0 9.20692 7.27137 0 11.4958 0 0 10.5513 12.0816 0 Q8IVU3 HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6) HERC6 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; protein ubiquitination [GO:0016567]; response to bacterium [GO:0009617]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630] ISQSMAEKWIAVK;VFTFGDNR;YFCWGADSR 3 2.9 0.91693 -0.34334 0 6.82094 0 0 0 4.37414 0 0 0 9.53419 0 0 Q8IVU9 CBCO1_HUMAN Ciliary-associated calcium-binding coiled-coil protein 1 CABCOCO1 C10orf107 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] ISLFQHYK 1 3.8 0.91499 -0.39033 0 0 0 0 0 0 0 11.3686 0 0 0 0 Q8IVV2 LOXH1_HUMAN Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) sensory perception of sound [GO:0007605] stereocilium [GO:0032420] DFACANNK;DLFHAELQTR;FILDAPDLGQLMK;FIVELEDVGEIIEK;VFEVTKTTESFASK 5 2.9 0.967 -1.2683 0 0 12.4411 0 0 9.81336 0 0 0 0 0 10.805 Q8IVV7 GID4_HUMAN Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog) GID4 C17orf39 VID24 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630] RQRAGGRPSRPHPAR 1 5 0.8496 -0.079145 0 0 0 0 0 8.96203 0 0 0 0 0 0 Q8IVW1 ARL17_HUMAN ADP-ribosylation factor-like protein 17 (ADP-ribosylation factor 7 variant) ARL17A ARL17P1; ARL17B ARF1P2 ARL17A PRO2667 Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ILILSLDTAGKTTILYKLK 1 10.7 0.86415 -0.084379 0 0 0 0 0 0 0 0 0 0 9.1315 0 Q8IVW4 CDKL3_HUMAN Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE) CDKL3 NKIAMRE Homo sapiens (Human) dendrite extension [GO:0097484]; negative regulation of axon extension [GO:0030517]; positive regulation of dendrite morphogenesis [GO:0050775]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] MLKRESK;TGHSDQMANENKR 2 3.4 0.71257 0.14586 0 0 4.2211 2.74306 0 0 0 0 0 0 0 10.3536 Q8IVW6 ARI3B_HUMAN AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) ARID3B BDP DRIL2 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] EPLQQQQQQQQQQQK;TAALEQLR 2 4.1 0.92954 -0.47405 0 0 0 0 0 2.36544 0 0 0 0 0 8.8846 Q8IW00 VSTM4_HUMAN V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv] VSTM4 C10orf72 Homo sapiens (Human) endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; retina blood vessel maintenance [GO:0097601]; retina vasculature development in camera-type eye [GO:0061298]; sprouting angiogenesis [GO:0002040]; vasodilation [GO:0042311] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] LLEEQRGALYR;VQEISRHRNK 2 6.6 0.91324 -0.38399 0 0 0 0 9.88264 0 0 0 0 0 0 0 Q8IW03 SIAH3_HUMAN Seven in absentia homolog 3 (Siah-3) SIAH3 Homo sapiens (Human) negative regulation of protein targeting to mitochondrion [GO:1903215]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630] LEVVVPHLRQIHR 1 4.8 0.8366 -0.030356 0 0 0 0 0 0 0 0 0 0 0 6.20138 Q8IW19 APLF_HUMAN Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) APLF C2orf13 PALF XIP1 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryo implantation [GO:0007566]; positive regulation of DNA ligation [GO:0051106]; protein localization to chromatin [GO:0071168]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of isotype switching [GO:0045191]; single strand break repair [GO:0000012] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] 3'-5' exonuclease activity [GO:0008408]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose binding [GO:0072572]; protein folding chaperone [GO:0044183] GPLLGITDK;TSCMYGANCYR 2 3.9 0.89831 -0.23294 0 0 0 0 0 0 0 2.35036 0 12.024 0 0 Q8IW35 CEP97_HUMAN Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) CEP97 LRRIQ2 Homo sapiens (Human) cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]; regulation of mitotic spindle assembly [GO:1901673] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516] LIQLSVANNRLVRMMGVAK;VLDGYVISQKESLKAEWLYSQGK 2 4.9 0.98041 -2.0365 0 12.6528 0 0 0 0 0 0 8.46638 8.50914 0 0 Q8IW36 ZN695_HUMAN Zinc finger protein 695 (Zinc finger protein SBZF3) ZNF695 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKAFNECSCFTDCK;IHIGENPYQCK;IHTGEKTFRCEECGK;LLSYLTQHRR;SLYRDVMLENYR 5 12.2 0.9803 -1.6779 10.9754 0 0 0 10.0077 0 0 4.44029 0 11.3675 5.23737 0 Q8IW40 DAA19_HUMAN Dynein axonemal assembly factor 19 (Coiled-coil domain-containing protein 103) DNAAF19 CCDC103 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157] protein homodimerization activity [GO:0042803] TFQDVATEISPEK 1 5.4 0.80135 0.014385 0 0 11.2832 0 0 0 10.8286 0 0 0 0 0 Q8IW41 MAPK5_HUMAN MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) MAPKAPK5 PRAK Homo sapiens (Human) cellular senescence [GO:0090398]; negative regulation of TOR signaling [GO:0032007]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; signal transduction [GO:0007165]; stress-induced premature senescence [GO:0090400] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FALKILLDRPKAR;LLIVMEMMEGGELFHR 2 6.1 0.0601 0.43631 0 7.5659 0 0 0 0 0 0 0 0 0 9.18683 Q8IW45 NNRD_HUMAN ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) NAXD CARKD Homo sapiens (Human) metabolite repair [GO:0110051]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453] SLHHHLRHDRR 1 2.8 0.95522 -0.97766 0 0 0 0 9.04868 0 0 0 0 0 0 0 Q8IW52 SLIK4_HUMAN SLIT and NTRK-like protein 4 SLITRK4 Homo sapiens (Human) axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of synapse organization [GO:0050807] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] IVVEQRK;LSTIDELDELFPSR;LWVEKLSDGIVVK 3 4.1 0.87624 -0.12475 0 10.2346 10.2099 9.95627 10.1127 0 8.48603 0 6.43074 5.92296 8.77232 0 Q8IW70 T151B_HUMAN Transmembrane protein 151B (Transmembrane protein 193) TMEM151B C6orf137 TMEM193 Homo sapiens (Human) membrane [GO:0016020] FFAENEGLDDYMEAR;QVTRYRNGDAYTTTQVYHER;VDVSSVRERVGR 3 8.3 0.95997 -1.0541 0 0 0 8.91418 0 0 0 0 0 5.40824 0 12.7247 Q8IW75 SPA12_HUMAN Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin) SERPINA12 Homo sapiens (Human) gluconeogenesis [GO:0006094]; lipid biosynthetic process [GO:0008610]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of lipid biosynthetic process [GO:0051055]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207] extracellular space [GO:0005615]; plasma membrane [GO:0005886] molecular function inhibitor activity [GO:0140678]; serine-type endopeptidase inhibitor activity [GO:0004867] IPSVLFLGK;LSIGNTLFIDQRLQPQR;TLSYIGVSKIFEEHGDLTKIAPHR;VGEAVHK 4 13.8 0.95513 -0.79549 12.2975 0 0 7.1058 0 11.437 0 0 0 0 0 0 Q8IW92 GLBL2_HUMAN Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) galactose catabolic process [GO:0019388] extracellular region [GO:0005576]; vacuole [GO:0005773] beta-galactosidase activity [GO:0004565] LDWSTLVPLR;RPARTLGLLLLVVLGFLVLR;TLGLLLLVVLGFLVLR;TLGLLLLVVLGFLVLRR 4 4.9 0.91777 -0.40102 0 8.31832 0 0 0 5.52105 0 0 0 12.0045 4.55102 8.01748 Q8IW93 ARHGJ_HUMAN Rho guanine nucleotide exchange factor 19 (Ephexin-2) ARHGEF19 Homo sapiens (Human) "regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]" cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EGKASGMEAR;LDTQEEPPLGSRSTNERR;LEADVLR;MLVENILKRTAQGSEDEDMATK 4 7.1 0.97776 -1.5245 0 0 0 0 7.46205 0 0 0 7.84894 8.76835 0 6.8254 Q8IWA0 WDR75_HUMAN WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) WDR75 UTP17 Homo sapiens (Human) positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] TQGFILNTK 1 1.1 0.90969 -0.31482 0 0 0 8.23903 0 0 0 0 0 0 0 0 Q8IWA4 MFN1_HUMAN Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) MFN1 Homo sapiens (Human) GTP metabolic process [GO:0046039]; mitochondrial fusion [GO:0008053]; mitochondrion localization [GO:0051646]; positive regulation of mitochondrial membrane potential [GO:0010918] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; outer mitochondrial membrane protein complex [GO:0098799] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606] HIEDGMGRNLADR;LSWTTHAK;LSWTTHAKERAFK 3 3.5 0.96143 -1.0616 0 0 0 0 0 0 0 0 0 7.75295 10.1092 0 Q8IWA5 CTL2_HUMAN Choline transporter-like protein 2 (Solute carrier family 44 member 2) SLC44A2 CTL2 PSEC0210 Homo sapiens (Human) choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; transmembrane transport [GO:0055085] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; transmembrane transporter activity [GO:0022857] DILLKGSAEEGKR;KRILIAIALIK;NAFFLLMR;QTWLAFMIILSILEVIIILLLIFLRKR 4 8 0.97932 -1.8989 0 0 0 0 0 0 0 5.39732 0 0 4.71309 0 Q8IWA6 CCD60_HUMAN Coiled-coil domain-containing protein 60 CCDC60 Homo sapiens (Human) LLEMVREDARR;LQSSPNSGAVRPFYASENLR 2 5.6 0.9744 -1.3939 0 0 0 0 0 9.99492 11.7885 0 0 0 0 0 Q8IWB1 IPRI_HUMAN "Inositol 1,4,5-trisphosphate receptor-interacting protein (Protein DANGER)" ITPRIP DANGER KIAA1754 Homo sapiens (Human) extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042] membrane [GO:0016020]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886] protein kinase inhibitor activity [GO:0004860] TALLHLLLLRQAADWKAGQLDAR 1 4.2 0.59338 0.17852 0 0 0 0 0 0 0 0 0 0 10.3006 0 Q8IWB4 S31A7_HUMAN Spermatogenesis-associated protein 31A7 (Protein FAM75A7) SPATA31A7 FAM75A4 FAM75A7 SPATA31A4 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] MTPEKHLNYLR;RQLEQHIKK;WIIQHWGNLGR 3 2.3 0.97818 -1.9306 0 11.7134 2.93589 0 4.01257 0 0 0 0 9.71673 0 0 Q8IWB7 WDFY1_HUMAN WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17) WDFY1 FENS1 KIAA1435 WDF1 ZFYVE17 Homo sapiens (Human) positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145] cell junction [GO:0030054]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] 1-phosphatidylinositol binding [GO:0005545]; zinc ion binding [GO:0008270] LLFSGASDNSIIMWDIGGR;SGNMLGR 2 6.3 0.94434 -0.6265 8.44956 0 10.2624 0 0 0 8.42735 0 0 0 0 0 Q8IWB9 TEX2_HUMAN Testis-expressed protein 2 (Transmembrane protein 96) TEX2 KIAA1738 TMEM96 Homo sapiens (Human) lipid transport [GO:0006869]; signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] lipid binding [GO:0008289] HLMKTLVK;HLMKTLVKSLSTDTSR;IEDTKRR;LEGGTLR;LEQEFQK 5 3.3 0.97395 -2.4615 12.8996 0 0 9.9523 0 0 0 9.41751 10.4673 6.59087 9.97871 0 Q8IWC1 MA7D3_HUMAN MAP7 domain-containing protein 3 MAP7D3 MDP3 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785] cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819] microtubule binding [GO:0008017]; tubulin binding [GO:0015631] IKAQEEADKR;QALIPIAKKR;RQQDANKETQLLEK;VAAANEIAKER 4 5.2 0.97617 -1.4822 0 0 0 0 0 0 9.80658 0 0 0 9.61903 0 Q8IWD4 CC117_HUMAN Coiled-coil domain-containing protein 117 CCDC117 Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] EEEEDDDCPVR;EEEEDDDCPVRK;REEEEDDDCPVR;VSVHCKK 4 7.2 0.82598 -0.019246 4.55342 0 6.13967 0 6.85524 5.52253 0 0 7.14608 0 9.13561 5.77902 Q8IWD4 CC117_HUMAN Coiled-coil domain-containing protein 117 CCDC117 Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] REEEEDDEIIDEDEEVEADR;VSVHCKK 2 13.2 0.57868 0.18087 0 0 0 0 0 0 5.39698 0 0 0 0 0 Q8IWD5 MFS6L_HUMAN Major facilitator superfamily domain-containing protein 6-like MFSD6L FP7072 Homo sapiens (Human) membrane [GO:0016020] GPGNPANLSGTKGK 1 2.4 0.88198 -0.17898 0 0 0 0 0 0 8.92264 0 0 0 0 0 Q8IWE2 NXP20_HUMAN Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) FAM114A1 NOXP20 Homo sapiens (Human) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] EAKEKEK;LTTAMCNEVASLSK;TLMERTVSLSQMLR 3 6.2 0.9648 -1.2204 9.27473 0 0 0 0 0 0 0 0 0 7.98885 0 Q8IWF2 FXRD2_HUMAN FAD-dependent oxidoreductase domain-containing protein 2 (Endoplasmic reticulum flavoprotein associated with degradation) FOXRED2 ERFAD Homo sapiens (Human) ERAD pathway [GO:0036503] endoplasmic reticulum lumen [GO:0005788] flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497] DYAPTGRR;DYAVFER;HYSRAYFPDARDMVR;YTGKANAEFNLRHDWNSLLSHDPR 4 7.9 0.93592 -0.53245 0 0 0 0 5.36286 0 0 10.1841 0 7.04352 0 7.12329 Q8IWF6 DEN6A_HUMAN Protein DENND6A (DENN domain-containing protein 6A) DENND6A FAM116A Homo sapiens (Human) positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] LPYIHFFHTVLK 1 2 0.80658 0.011919 0 0 0 0 0 0 0 0 9.77632 0 0 0 Q8IWF9 CCD83_HUMAN Coiled-coil domain-containing protein 83 CCDC83 HSD9 Homo sapiens (Human) EENSGTEFGDTDMK;EWATQNAVKLIDK;GSYLEIWENDWLKK;HLLLLPLESCLISARRCWR;NQKYHER;WKFERDQEK 6 17.1 0.97208 -2.7086 0 0 5.98582 3.40122 0 0 0 0 10.3596 8.48438 12.4656 10.2273 Q8IWG1 DNAI3_HUMAN Dynein axonemal intermediate chain 3 (Testis development protein NYD-SP29) (WD repeat-containing protein 63) DNAI3 WDR63 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell migration [GO:0030336]; positive regulation of osteoblast differentiation [GO:0045669] axonemal dynein complex [GO:0005858]; cytoplasm [GO:0005737]; inner dynein arm [GO:0036156] Arp2/3 complex binding [GO:0071933]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] AGGSRSK;DVGMQVIPQIKDISTQTK;EQMQAELKMDYESYLELEK;EVKHLEYVEQR;ISLNEDHLLCK;NATTQYYPREFSEEEK;QITYMISR 7 10.1 0.98092 -1.7455 12.8415 12.7597 0 0 0 8.99879 0 11.1305 0 0 0 11.006 Q8IWI9 MGAP_HUMAN MAX gene-associated protein (MAX dimerization protein 5) MGA KIAA0518 MAD5 Homo sapiens (Human) cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEEEGIREEEEQLKEK;EKECGDSLEK;ISGDMRGIQYK;KCVGASQECK;LEYIYAK;LKLCKAGRPPK;LLTGIKSPRSYTPKPNPVIR;LTNNTLDQEGHIILHSMHR;LTNNTLDQEGHIILHSMHRYLPRLHLVPAEK;QSTISPSTSYSLKPHSVPPVSRK;TSLNIKR;TVQNLSK;VAVLEVR;VGALQQK 14 5.4 0.9767 -5.4231 15.4674 14.1159 7.2521 10.3471 0 7.72103 0 9.92844 0 0 0 11.4527 Q8IWJ2 GCC2_HUMAN GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) GCC2 KIAA0336 RANBP2L4 Homo sapiens (Human) "Golgi ribbon formation [GO:0090161]; late endosome to Golgi transport [GO:0034499]; microtubule anchoring [GO:0034453]; microtubule organizing center organization [GO:0031023]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to lysosome [GO:0006622]; recycling endosome to Golgi transport [GO:0071955]; regulation of protein exit from endoplasmic reticulum [GO:0070861]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] AETEQQCLSLKK;DEFFHER;DQNDQKLEK;DQVRHLQEEHRK;EALQSDLLEMKNANEK;ETEATNAILMEQIKLLK;KQMMLIQK;MLQETVSK;QEREHLEMLIDQLKIK;SLLRDYEQEK;VRVHNVLKQQK 11 7.5 0.97578 -4.3501 0 6.8175 7.98993 5.84235 9.22072 7.38094 0 0 0 9.49201 6.71548 8.03854 Q8IWK6 AGRA3_HUMAN Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) ADGRA3 GPR125 UNQ556/PRO1113 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CPNSSAESSCTNKSASSFKNSSQGCK;EAKACSRIVQCLQR;FYLIGGGIPIIVCGITAAANIK;IAHGADAVAAR;ISELKNGSFSGLSLLER;RIAHGADAVAAR;STGFTGMTCTVFQKVAASDRTGLSDYGR;VLWLAQR 8 9.5 0.97748 -5.8864 0 0 0 10.6916 10.6511 0 0 0 0 6.85387 0 0 Q8IWL3 HSC20_HUMAN "Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]" HSCB DNAJC20 HSC20 Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087] HSTLVNDAYK;SFRVDTAKLQHR;TLLAPLSR;TLLAPLSRGLYLLK 4 15.3 0.97243 -2.7875 10.6738 0 17.3359 0 14.2567 0 0 9.52857 16.7391 17.4216 7.22554 0 Q8IWN6 F223A_HUMAN Protein FAM223A (SPCX) FAM223A CXorf52 LINC00204A NCRNA00204 Homo sapiens (Human) AGGVGGK 1 5.7 0.70338 0.16064 0 10.7955 4.96019 0 0 0 0 10.9332 9.31777 0 0 0 Q8IWN7 RP1L1_HUMAN Retinitis pigmentosa 1-like 1 protein RP1L1 Homo sapiens (Human) axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750] ATMGATR;GGQPGPK;NGSWGPK;VGCREVFGRGGQPGPK;VSPMSPK 5 1.5 0.95453 -0.95198 0 9.67485 9.25798 6.07161 0 0 9.93603 0 0 9.76954 0 0 Q8IWN7 RP1L1_HUMAN Retinitis pigmentosa 1-like 1 protein RP1L1 Homo sapiens (Human) axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750] VLPDMKFHQR 1 4.5 0.94101 -0.59876 0 0 0 0 0 8.67617 0 0 0 0 0 0 Q8IWP9 CC28A_HUMAN Coiled-coil domain-containing protein 28A (CCRL1AP) CCDC28A C6orf80 Homo sapiens (Human) LYLLRHFR;NAIPVSK 2 5.5 0.95572 -0.9844 0 0 0 0 5.98959 0 0 0 0 0 0 0 Q8IWQ3 BRSK2_HUMAN Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; neuron differentiation [GO:0030182]; protein phosphorylation [GO:0006468]; regulation of ATP-dependent activity [GO:0043462]; regulation of axonogenesis [GO:0050770]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of neuron projection development [GO:0010975]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]; regulation of synaptic vesicle clustering [GO:2000807]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; ATPase regulator activity [GO:0060590]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] NSFLGSPR;SLDIAEAHPQFSK 2 3 0.79843 0.014883 0 0 0 0 0 0 0 0 0 0 7.53107 0 Q8IWQ3 BRSK2_HUMAN Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; neuron differentiation [GO:0030182]; protein phosphorylation [GO:0006468]; regulation of ATP-dependent activity [GO:0043462]; regulation of axonogenesis [GO:0050770]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of neuron projection development [GO:0010975]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]; regulation of synaptic vesicle clustering [GO:2000807]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; ATPase regulator activity [GO:0060590]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] GGAAHHR;LSKCDEK;NSFLGSPR 3 2.9 0.98013 -1.8281 0 0 0 0 0 0 0 0 0 6.2971 0 0 Q8IWR0 Z3H7A_HUMAN Zinc finger CCCH domain-containing protein 7A ZC3H7A ZC3H7 ZC3HDC7 HSPC055 Homo sapiens (Human) miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] AYDAVAKCSLAVPQDEHVIKLTQELAQK;LTQELAQK 2 2.9 0.9277 -0.45687 0 0 0 0 0 0 0 0 0 0 0 7.90044 Q8IWS0 PHF6_HUMAN PHD finger protein 6 (PHD-like zinc finger protein) PHF6 CENP-31 KIAA1823 Homo sapiens (Human) blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122] kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; tubulin binding [GO:0015631] CTLCSQPGATIGCEIKACVK;DKECGQLLISENQK;ECGQLLISENQK;SRKGRPR;YIENMSR 5 13.2 0.97436 -3.8309 0 0 0 0 0 0 7.95431 7.45541 0 0 0 12.752 Q8IWT1 SCN4B_HUMAN Sodium channel regulatory subunit beta-4 SCN4B Homo sapiens (Human) AV node cell action potential [GO:0086016]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; establishment of localization in cell [GO:0051649]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; neuronal action potential [GO:0019228]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006] LIIFILK;LIIFILKK 2 3.5 0.96382 -1.1939 0 0 0 0 0 6.18838 0 0 0 0 0 0 Q8IWT3 CUL9_HUMAN Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) CUL9 H7AP1 KIAA0708 PARC Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461]; cytosol [GO:0005829] ATP binding [GO:0005524]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] ADCLSTGMELLRR;DPGGLDEVAMGEMEADVQALVR;RLQQETQPFLLLLR;SEASFSEEETESLK 4 2.5 0.015414 0.72967 0 0 0 9.51367 8.79854 8.06808 0 2.32256 9.54301 3.64247 0 12.2844 Q8IWT6 LRC8A_HUMAN Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular glucose homeostasis [GO:0001678]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic anion transport [GO:0006820]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; pre-B cell differentiation [GO:0002329]; protein hexamerization [GO:0034214]; response to osmotic stress [GO:0006970]; spermatogenesis [GO:0007283]; taurine transmembrane transport [GO:0015734] cell surface [GO:0009986]; cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; identical protein binding [GO:0042802]; volume-sensitive anion channel activity [GO:0005225] EGEQAKALFEK;FRTHVEEGDIVYRLYMR 2 3.5 0.85389 -0.08043 0 0 0 0 0 0 0 8.0983 0 0 0 0 Q8IWU6 SULF1_HUMAN Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form] SULF1 KIAA1077 Homo sapiens (Human) apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449] GPRDLQASSGGNRGR;TFAVYLNNTGYRTAFFGK 2 3.8 0.97538 -1.4729 0 0 0 0 0 0 0 0 8.71562 0 10.9738 11.4382 Q8IWU9 TPH2_HUMAN Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) TPH2 NTPH Homo sapiens (Human) aromatic amino acid metabolic process [GO:0009072]; serotonin biosynthetic process [GO:0042427] cytosol [GO:0005829]; neuron projection [GO:0043005] iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510] KISELDKCSHR;TWGVVFRELSK 2 4.5 0.97592 -2.3083 0 9.55361 0 0 0 0 0 0 0 0 0 0 Q8IWV1 LAX1_HUMAN Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX) LAX1 LAX Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; lymphocyte activation [GO:0046649]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169] HREEMSNEDSSDYENVLTAK 1 5 0.81725 -0.01737 0 0 0 0 3.42008 0 0 0 0 0 0 0 Q8IWV2 CNTN4_HUMAN Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2) CNTN4 Homo sapiens (Human) axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron differentiation [GO:0045665]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167]; synapse organization [GO:0050808] axon [GO:0030424]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] ALDNESEVK;GRIQGYEVKYWR;LQFAYLDNFK;VGVFNNK;YVCMVQTSVDRLSAAADLIVR 5 5.8 0.95518 -0.83262 0 0 8.53306 6.60539 0 7.38509 10.4635 0 0 0 6.78686 8.75669 Q8IWV7 UBR1_HUMAN E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) UBR1 Homo sapiens (Human) cellular response to L-leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151] L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DESLKDFNMYFYHYSK;EMVILFATTIYRIGLKVPPDER;ENSRCPLNEEVIVQAR;FLLLVLQRYELAEAFNKTISTK;GPSVTEK;HSGAFQLCGR;ISGYNIRHAK;ITCPQVLIQKHLVRLLSVVLPNIK;TVVQSCGHSLETK 9 8 0.975 -4.1121 7.91797 0 11.9774 0 6.03565 0 6.73931 14.4786 8.4248 0 0 0 Q8IWV8 UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) UBR2 C6orf133 KIAA0349 Homo sapiens (Human) cellular response to L-leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; positive regulation of T cell receptor signaling pathway [GO:0050862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] histone H2A ubiquitin ligase activity [GO:0141053]; L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EVYQHLAHYVPKIYCR;LLAGLHVLLSK;LTHVISMMQDWCASDEK;NGFSLVNQIYYYHNVKCR;VGEPTYSCR 5 4 0.95424 -0.91479 0 9.92126 5.74948 0 0 0 0 0 0 9.4379 8.22997 0 Q8IWV8 UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) UBR2 C6orf133 KIAA0349 Homo sapiens (Human) cellular response to L-leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; positive regulation of T cell receptor signaling pathway [GO:0050862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] histone H2A ubiquitin ligase activity [GO:0141053]; L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CLKCSGILLMKTK;LLAGLHVLLSK;LTHVISMMQDWCASDEK;NGFSLVNQIYYYHNVKCR 4 10.3 0.83808 -0.037052 0 0 0 0 0 8.97453 0 0 0 0 0 0 Q8IWW6 RHG12_HUMAN Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) "actin filament organization [GO:0007015]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; regulation of postsynapse assembly [GO:0150052]; small GTPase-mediated signal transduction [GO:0007264]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096] IAENGKK;IVIKQGERYILVK 2 2.4 0.95495 -0.9004 0 0 6.00565 0 0 0 0 0 0 0 0 0 Q8IWW8 HOT_HUMAN "Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1) (Fe-containing alcohol dehydrogenase)" ADHFE1 HMFT2263 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; glutamate catabolic process via 2-hydroxyglutarate [GO:0019552]; lipid metabolic process [GO:0006629] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] alcohol dehydrogenase (NAD+) activity [GO:0004022]; hydroxyacid-oxoacid transhydrogenase activity [GO:0047988]; metal ion binding [GO:0046872] LPPVQVAMDSLVK 1 2.8 0.88107 -0.1701 0 0 0 0 0 0 0 0 0 0 10.0674 0 Q8IWX7 UN45B_HUMAN Protein unc-45 homolog B (Unc-45B) (SMUNC45) UNC45B CMYA4 UNC45 Homo sapiens (Human) cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517] A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] Hsp90 protein binding [GO:0051879] AIDINSSDIK;DQALNLLNKNVPRK;LAKQCRK;MFEILLDENSEADKREK;TIYVVDNGLR 5 6.2 0.9753 -3.6041 0 0 0 0 0 10.4402 0 0 0 0 0 11.8995 Q8IWX8 CHERP_HUMAN Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) CHERP DAN26 SCAF6 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017] RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] DKWDQYKGVGVALDDPYENYR;SRSKSYSPGR 2 3.4 0.98057 -1.5533 0 0 0 9.05723 0 0 0 0 0 5.58027 0 0 Q8IWY4 SCUB1_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] MEEASDTCEADCLRK;MGAAAVR;SPSKEVSHITAEFEIETK 3 4 0.20166 0.33235 0 4.85305 10.6721 0 0 7.94889 0 0 0 0 7.87227 0 Q8IWY8 ZSC29_HUMAN Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) ZSCAN29 ZNF690 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CADCGKSFSR;GNESDCR;IPRYLHQGKGNESDCR;SALRENGTNSETFRQR;TLEQCRTK 5 5.9 0.98049 -1.638 0 0 5.49205 0 5.3952 0 0 0 0 8.96506 0 10.8855 Q8IWY9 CDAN1_HUMAN Codanin-1 CDAN1 UNQ664/PRO1295 Homo sapiens (Human) chromatin organization [GO:0006325]; import into nucleus [GO:0051170]; protein localization [GO:0008104] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GERRGCSR;LGRLWRLQER;TPGASAALPGRPGGPPR 3 2.9 0.81366 -0.010202 0 0 2.65979 6.72342 8.95029 0 9.39669 0 0 0 0 0 Q8IWZ3 ANKH1_HUMAN Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) innate immune response [GO:0045087] cytoplasm [GO:0005737] RNA binding [GO:0003723] TILEGIDPAK 1 1.6 0.89454 -0.22668 0 11.404 0 0 0 0 0 11.1547 0 0 0 0 Q8IWZ4 TRI48_HUMAN E3 ubiquitin-protein ligase TRIM48 (EC 2.3.2.27) (RING finger protein 101) (Tripartite motif-containing protein 48) TRIM48 RNF101 Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LLKKMQSLWEK;MQSLWEKACENQR;TIQQRNLKTNIR 3 12.9 0.91758 -0.35979 0 0 0 3.49761 3.97545 0 6.69195 3.1795 7.67666 3.64374 0 0 Q8IWZ5 TRI42_HUMAN Tripartite motif-containing protein 42 TRIM42 Homo sapiens (Human) protein ubiquitination [GO:0016567] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AVRYEIDNDLMEFNILK;CCCTASSNLNCYYYESRCCR;ETAMCVCCPCCTWQRCCPQLCSCLCCK;LLCTFCK;METAMCVCCPCCTWQR;NSFKADKEAK 6 11.3 0.97776 -1.9517 0 0 6.19987 7.79032 6.59667 0 7.82655 0 6.22793 0 7.18874 0 Q8IWZ6 BBS7_HUMAN BBSome complex member BBS7 (BBS2-like protein 1) (Bardet-Biedl syndrome 7 protein) BBS7 BBS2L1 Homo sapiens (Human) brain development [GO:0007420]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; digestive tract morphogenesis [GO:0048546]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; limb development [GO:0060173]; melanosome transport [GO:0032402]; non-motile cilium assembly [GO:1905515]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; primary palate development [GO:1903929]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; visual perception [GO:0007601] axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] GTNVKTK;INDVICLPVERLSR;KGEGVFK 3 3.9 0.97777 -1.5246 0 0 0 0 9.80096 0 0 0 0 0 0 0 Q8IWZ8 SUGP1_HUMAN SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) SUGP1 SF4 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] DVAGKANRWFGVAPPK;EIEAKMEQK 2 3.9 0.97378 -1.3957 0 0 0 0 0 0 0 0 0 0 6.16076 0 Q8IX01 SUGP2_HUMAN "SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)" SUGP2 KIAA0365 SFRS14 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ADHRVVGTIDQLVKR;ITPKTQGTNQIQK;MIPPTKPEIQAK;NCFFEIIKPFDKYIMR;VIEGSLSPK 5 6 0.98024 -1.861 8.0898 10.287 10.4984 0 0 0 0 11.6537 0 0 11.1714 0 Q8IX03 KIBRA_HUMAN Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) WWC1 KIAA0869 KIBRA Homo sapiens (Human) cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]; regulation of intracellular transport [GO:0032386] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]" kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591]; transcription coactivator activity [GO:0003713] FISPRKWTQGEVEQLEMAR;LGSQVSLVSGSSSSSK;LIRTSLDLELDLQATR;PRPELPLPEGWEEARDFDGKVYYIDHTNR;STRWYNLLSYK;YDPEILK 6 8.8 0.97531 -2.3524 0 0 13.1162 0 0 9.2857 0 0 0 10.8173 4.89059 0 Q8IX04 UEVLD_HUMAN Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein) UEVLD UEV3 Homo sapiens (Human) carboxylic acid metabolic process [GO:0019752]; endosome to lysosome transport [GO:0008333]; protein modification process [GO:0036211]; protein transport [GO:0015031] ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ubiquitin binding [GO:0043130]" SVTQAGV;SWANHENKTVNK 2 8.8 0.81402 0.00046867 0 0 0 0 0 10.8111 0 0 0 0 0 0 Q8IX04 UEVLD_HUMAN Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein) UEVLD UEV3 Homo sapiens (Human) carboxylic acid metabolic process [GO:0019752]; endosome to lysosome transport [GO:0008333]; protein modification process [GO:0036211]; protein transport [GO:0015031] ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ubiquitin binding [GO:0043130]" LSTFPANR;SWANHENKTVNK;VEIMTYVTWK 3 15.1 0.98135 -1.7035 0 0 0 0 0 0 4.98768 0 0 14.5872 0 0 Q8IX06 GOR_HUMAN Putative exonuclease GOR (EC 3.1.-.-) (Antigen GOR homolog) (RNA exonuclease 1 homolog-like 1) REXO1L1P GOR REXO1L1 Homo sapiens (Human) rRNA 3'-end processing [GO:0031125] cytoplasm [GO:0005737]; nucleus [GO:0005634] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] DQLCYYHWGR;SGMACKTTATTSSK 2 3.6 0.98075 -1.6163 0 0 0 0 0 0 0 0 0 0 9.62143 0 Q8IX07 FOG1_HUMAN Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) ZFPM1 FOG1 ZFN89A Homo sapiens (Human) atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cardiac muscle tissue morphogenesis [GO:0055008]; definitive erythrocyte differentiation [GO:0060318]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; mitral valve formation [GO:0003192]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of mast cell differentiation [GO:0060377]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; primitive erythrocyte differentiation [GO:0060319]; regulation of chemokine production [GO:0032642]; regulation of definitive erythrocyte differentiation [GO:0010724]; T-helper cell lineage commitment [GO:0002295]; tricuspid valve formation [GO:0003195]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] RAPEDAPAAR;VCPFPQCRK 2 1.9 0.96638 -1.2765 0 0 0 0 0 0 0 9.48969 0 0 0 0 Q8IX12 CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) CCAR1 CARP1 DIS Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] EEDEDDDR;IVSQPQPAR;KSEDDKEEEER;LLLPTPTVK;SEKEEDEDDDR;SEWETLSR;VVLRESCFYRK;YCKERPSK 8 5.8 0.97559 -3.4343 5.50335 0 0 0 0 6.68314 6.32557 0 0 11.0712 0 11.8849 Q8IX15 HOMEZ_HUMAN Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) HOMEZ KIAA1443 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" RDQLHFK;VEPEEPSQMPPLPQSHQKLK 2 4.9 0.95384 -0.92679 0 0 0 12.1947 0 0 11.9092 12.1279 0 0 0 0 Q8IX18 DHX40_HUMAN Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD) DHX40 DDX40 ARG147 Homo sapiens (Human) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EVREDARR;FDDCSSKETAIK;VAAISVAQR;VAAISVAQRVAEEMK 4 4.5 0.96683 -1.2793 8.31945 0 10.0115 10.5793 0 0 0 12.8443 0 9.28246 0 0 Q8IX21 SLF2_HUMAN SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) SLF2 C10orf6 FAM178A Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] ISGGPLR;KQTTVAEADIFNNSSRSLSSR;QGRGIKSPIR;SSSDSWEPTSAGSKQNK 4 4.7 0.9462 -0.65599 0 9.29027 4.78806 0 0 0 0 4.29087 0 7.21072 0 0 Q8IX21 SLF2_HUMAN SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) SLF2 C10orf6 FAM178A Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] RGRVAGAR 1 12.7 0.87094 -0.095167 0 0 0 2.899 2.4471 0 0 0 3.56755 3.80002 0 8.40497 Q8IX29 FBX16_HUMAN F-box only protein 16 FBXO16 FBX16 Homo sapiens (Human) LRKAQSMMSR;NLAELDQLWMLKCLR 2 8.6 0.98001 -1.8365 0 0 0 9.65644 0 0 0 9.65951 0 0 0 0 Q8IX30 SCUB3_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 3" SCUBE3 CEGF3 Homo sapiens (Human) positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of osteoblast differentiation [GO:0045669]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] BMP binding [GO:0036122]; BMP receptor binding [GO:0070700]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] CPGNTSTDFDGSTSVAQCK;DIDECRLNNGGCDHICR;GSGRVPGLCLLVLLVHAR;NCQDIDECSFDR 4 6.6 0.88775 -0.20259 0 0 7.90617 0 0 0 10.4561 0 0 3.24505 6.94158 5.84985 Q8IX94 CTGE4_HUMAN cTAGE family member 4 (Protein cTAGE-4) CTAGE4 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] DLEEELERTVHFYQK;LNRSNSELEDEILCLEKDLK;LSPVLPGGGGR;LTVEENYR;LTVEENYRIEEEEK;SMPSEMESSRNDAK 6 9.5 0.95919 -1.0406 0 0 0 9.59077 0 0 0 0 11.9531 0 0 0 Q8IXB1 DJC10_HUMAN DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) DNAJC10 ERDJ5 UNQ495/PRO1012 Homo sapiens (Human) ERAD pathway [GO:0036503]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] "ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; disulfide oxidoreductase activity [GO:0015036]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase activity [GO:0015035]; protein-folding chaperone binding [GO:0051087]" GQGTKEYEIHHGK;NFQEEQINTR 2 2.9 0.90147 -0.26087 11.3081 11.1707 7.90002 0 0 0 0 0 0 4.16245 0 0 Q8IXB3 TARG1_HUMAN Trafficking regulator of GLUT4 1 (Dispanin subfamily B member 1) (DSPB1) (Interferon-induced transmembrane domain-containing protein D3) (Protein located at seventeen-p-thirteen point three 1) (Tumor suppressor candidate 5) TRARG1 IFITMD3 LOST1 TUSC5 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; endosome to plasma membrane protein transport [GO:0099638]; glucose import in response to insulin stimulus [GO:0044381]; protein localization to plasma membrane [GO:0072659]; vesicle fusion to plasma membrane [GO:0099500] cytoplasmic vesicle membrane [GO:0030659]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LARLLSITLIIMGIVIIMVAVTVNFTVQKK;LLSITLIIMGIVIIMVAVTVNFTVQKK 2 16.9 0.083981 0.38356 0 0 0 0 0 0 0 6.89881 0 0 0 6.61609 Q8IXF0 NPAS3_HUMAN Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) NPAS3 BHLHE12 MOP6 PASD6 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" APTKPSFQQDPSR;IDCHMFVTR;SELCMRK;YVESESDLR 4 4.1 0.95887 -1.0062 0 6.40968 0 10.7341 9.46875 0 9.91555 0 0 0 0 0 Q8IXH7 NELFD_HUMAN Negative elongation factor C/D (NELF-C/D) (TH1-like protein) NELFCD NELFD TH1 TH1L HSPC130 Homo sapiens (Human) negative regulation of transcription elongation by RNA polymerase II [GO:0034244] membrane [GO:0016020]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] INQDHKHKYIHILAYAASVVETWK;KTLLDRMVHLLSR 2 6.3 0.9559 -0.87042 0 0 0 0 0 0 6.76832 11.5787 0 0 0 0 Q8IXI1 MIRO2_HUMAN Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) RHOT2 ARHT2 C16orf39 Homo sapiens (Human) cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] GLGHQDTR;LDQEKGQTQR;NLRNISELFYYAQK;VFEKHDQDR 4 6.6 0.97507 -3.9026 0 8.31936 0 0 0 0 11.6206 0 12.1545 0 0 0 Q8IXI2 MIRO1_HUMAN Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) RHOT1 ARHT1 Homo sapiens (Human) cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; regulation of mitochondrion organization [GO:0010821] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DVRILLVGEPRVGK 1 2.3 0.7651 0.065333 0 0 0 0 0 0 8.77873 0 0 0 0 0 Q8IXJ9 ASXL1_HUMAN Polycomb group protein ASXL1 (Additional sex combs-like protein 1) ASXL1 KIAA0978 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; chromatin organization [GO:0006325]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; homeostasis of number of cells [GO:0048872]; lung saccule development [GO:0060430]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; podocyte development [GO:0072015]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of kidney size [GO:0035564]; response to retinoic acid [GO:0032526]; thymus development [GO:0048538] nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear retinoic acid receptor binding [GO:0042974]; peroxisome proliferator activated receptor binding [GO:0042975]; transcription coactivator activity [GO:0003713] KRSRPDLR;SVASDVPLYK;VEQWKEK 3 1.6 0.96669 -1.2691 0 13.9187 0 0 0 0 0 0 9.73405 0 0 0 Q8IXK0 PHC2_HUMAN Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) PHC2 EDR2 PH2 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; spermatogenesis [GO:0007283] heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] SLPGLPSSFPK 1 4.1 0.79428 0.016166 0 0 0 0 0 0 9.94342 0 0 12.2157 0 0 Q8IXK2 GLT12_HUMAN Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12) GALNT12 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EALLVLLALLALAGLGSVLR;EALLVLLALLALAGLGSVLRAQR;ESSDSFVPLLR;KESSDSFVPLLR;RGREALLVLLALLALAGLGSVLR;TPRPGRR 6 7.7 0.94138 -0.61115 0 5.54186 9.55589 6.65048 0 6.81877 0 0 5.52547 11.1347 0 0 Q8IXL6 FA20C_HUMAN Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK) FAM20C DMP4 Homo sapiens (Human) biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; enamel mineralization [GO:0070166]; odontoblast differentiation [GO:0071895]; osteoclast maturation [GO:0036179]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of phosphorus metabolic process [GO:0051174] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; manganese ion binding [GO:0030145]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AVRDCVER;EIRDVTRDK;MMLVRRFR 3 4.3 0.92613 -0.45289 0 0 0 0 0 0 8.37025 10.906 0 0 7.78267 0 Q8IXM2 BAP18_HUMAN BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) BACC1 BAP18 C17orf49 Homo sapiens (Human) chromatin organization [GO:0006325] cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; NURF complex [GO:0016589] DNA binding [GO:0003677]; identical protein binding [GO:0042802] TSASTKVGEIFSAAGAAFTK 1 11.6 0.91575 -0.43086 0 0 0 0 0 0 0 0 9.84345 0 0 0 Q8IXM3 RM41_HUMAN "Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog)" MRPL41 BMRP MRPL27 RPML27 PIG3 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GIGFLTSGWR;MSKWTSK 2 12.4 0.98027 -1.8701 0 0 0 0 0 0 0 0 0 0 9.51655 0 Q8IXP5 OCAT1_HUMAN POU domain class 2-associating factor 2 (Oct coactivator from tuft cells 1) (Protein OCA-T1) (POU class 2 homeobox-associating factor 2) POU2AF2 C11orf53 Homo sapiens (Human) cytosol [GO:0005829]; nucleus [GO:0005634] POU domain binding [GO:0070974]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713] ESVPGDYSKR 1 3.5 0.86433 -0.084284 0 9.34851 14.8152 11.3576 0 0 12.7528 12.6756 0 0 0 0 Q8IXQ4 GPAM1_HUMAN GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) GPALPP1 KIAA1704 LSR7 AD029 Homo sapiens (Human) ARGTAEDEERDPSPVAGPALPPNYK 1 7.4 0.95737 -1.0215 0 0 0 0 0 0 0 0 0 0 0 11.2927 Q8IXQ6 PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9) PARP9 BAL BAL1 Homo sapiens (Human) cell migration [GO:0016477]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of catalytic activity [GO:0043086]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of response to type II interferon [GO:0060330]; viral protein processing [GO:0019082] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] ADP-D-ribose binding [GO:0072570]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; nucleotidyltransferase activity [GO:0016779]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389] FVIFPTDLEIYK;GLWRSLGQWTIQQQK;ITSLSLLFQK;LFQQVPYQFCNVVCRVGFQR;SKMLSLNNYSVPQSTREEK;SLGQWTIQQQK;SLGQWTIQQQKTQDEMK;SLQVFRKMLTPR 8 11 0.9726 -2.7495 17.2815 0 16.8854 10.3981 0 13.214 0 0 11.3201 14.3626 14.3519 12.0076 Q8IXR5 F178B_HUMAN Protein FAM178B FAM178B HSPC234 Homo sapiens (Human) VLQASREAPAQR 1 1.8 0.92393 -0.44813 0 0 0 0 0 0 4.90694 5.44152 0 0 0 0 Q8IXS0 F217A_HUMAN Protein FAM217A FAM217A C6orf146 Homo sapiens (Human) KLYRQNIVLNRPFSIQK;RNWSNAGKYR 2 5.3 0.32839 0.24511 11.9411 0 6.86913 0 0 0 0 0 0 0 0 0 Q8IXS2 DRC2_HUMAN Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65) (Testis development protein NYD-SP28) CCDC65 DRC2 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; regulation of cilium movement [GO:0003352] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514] EKMAKTPLSDEK;IVDKGEKILK;LLAEEEMAK;TIIDQHEK 4 8.1 0.97648 -2.1842 0 0 0 13.5714 13.3093 9.6409 12.1523 0 0 0 11.7642 13.7031 Q8IXS8 HYCC2_HUMAN Hyccin 2 HYCC2 FAM126B Homo sapiens (Human) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; plasma membrane [GO:0005886] TASASSSK;VCVSGFPRQHEKHWK 2 4.3 0.97479 -1.3813 0 0 0 0 0 0 14.749 0 0 0 0 9.51438 Q8IXT1 DDIAS_HUMAN DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein) DDIAS C11orf82 NOXIN Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752] cytoplasm [GO:0005737]; nucleus [GO:0005634] LENKQYCR;SLSEDFIQPSQK 2 2 0.98036 -1.6564 0 0 0 9.55637 0 0 0 0 0 0 0 10.8344 Q8IXT1 DDIAS_HUMAN DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein) DDIAS C11orf82 NOXIN Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752] cytoplasm [GO:0005737]; nucleus [GO:0005634] ALVACQIVLPDPATQDAKTK 1 11.2 0.81284 -0.015389 0 0 0 0 0 0 0 0 0 0 0 9.61528 Q8IXT5 RB12B_HUMAN RNA-binding protein 12B (RNA-binding motif protein 12B) RBM12B Homo sapiens (Human) regulation of RNA splicing [GO:0043484] nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] EEDWRRPLEEDWRRPLEEDFR;GVGLGEALVKFKSEEQAMK;NFPFDVTK;TIEMKRTDR 4 5.7 0.97312 -2.9467 0 3.20621 5.76129 0 10.7904 0 0 0 0 0 6.66988 10.5533 Q8IXV7 KLD8B_HUMAN Kelch domain-containing protein 8B KLHDC8B FP17659 Homo sapiens (Human) mitotic cytokinetic process [GO:1902410]; mitotic nuclear division [GO:0140014]; nuclear chromosome segregation [GO:0098813] cellularization cleavage furrow [GO:0110070]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; midbody [GO:0030496] TWTRHPSLPSR 1 3.1 0.92189 -0.44544 0 0 0 0 0 0 0 0 0 4.70708 0 0 Q8IXW0 LMTD2_HUMAN Lamin tail domain-containing protein 2 LMNTD2 C11orf35 Homo sapiens (Human) lamin filament [GO:0005638] structural constituent of chromatin [GO:0030527] IVAVSCREK;SSHSQEK 2 2.5 0.97883 -2.114 0 0 0 0 0 10.7412 0 0 0 0 0 0 Q8IXW5 RPAP2_HUMAN Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) RPAP2 C1orf82 Homo sapiens (Human) PERK-mediated unfolded protein response [GO:0036499]; snRNA transcription [GO:0009301] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] KAELEAAVRK;TPVWVREEER;TPVWVREEERHPDFQLLK 3 4.6 0.98101 -1.6931 8.26346 0 0 0 0 0 0 9.42215 0 0 0 0 Q8IXZ2 ZC3H3_HUMAN Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) ZC3H3 KIAA0150 SMICL ZC3HDC3 Homo sapiens (Human) mRNA 3'-end processing [GO:0031124]; mRNA transport [GO:0051028]; positive regulation of activin receptor signaling pathway [GO:0032927] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412] APLTKDSGKPLHIKPR;LSKTSGQPSDAGSRPLLRTGR 2 3.9 0.93304 -0.51366 9.66423 0 0 0 0 0 0 0 0 2.04439 0 0 Q8IY17 PLPL6_HUMAN Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase) PNPLA6 NTE Homo sapiens (Human) glycerophospholipid catabolic process [GO:0046475]; phosphatidylcholine metabolic process [GO:0046470] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] lysophospholipase activity [GO:0004622] LFPSPGLPTRTSPVR;RSTDLNESR;SIHRVFQDK;SWCSGHLHLRCPRR;TVEWLNMR;VLGHFEKPLFLELCRHMVFQR;VLTGNTIALVLGGGGAR;VPKTPAPDGPRYR;YPESLVRVVQIIMVR 9 8.8 0.97634 -4.6493 0 0 0 0 10.0032 10.576 11.6309 9.04778 0 0 11.8608 8.84188 Q8IY18 SMC5_HUMAN Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) SMC5 KIAA0594 SMC5L1 Homo sapiens (Human) "cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle phase transition [GO:0044772]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; protein localization to chromosome, centromeric region [GO:0071459]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; stem cell population maintenance [GO:0019827]; telomere maintenance via recombination [GO:0000722]" "cell junction [GO:0030054]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697] DPSSEVPSKR;ITFTQPS;KASTKIK;LMEQDTCNLEEEERKASTK;QDVERFYER;QKQDVIERK;VNAVIAPK 7 5.8 0.97824 -2.143 0 5.80748 0 6.22058 0 0 8.6047 0 0 6.29265 7.69592 9.97971 Q8IY21 DDX60_HUMAN Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60) DDX60 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727] AELTSWIK;FQLQYMGHYLIR;LVLYGERYNDLEK;NLPSGEVLCGVFTREYR;QLIARCLK;QNIKDAYTTLLNQLER;SVVFAQNSVYLDALNYR;VITSHWAEDMKPLLQMKK 8 6.4 0.97284 -2.7723 4.10819 0 0 0 0 9.55386 8.51483 11.8903 8.9991 0 0 0 Q8IY22 CMIP_HUMAN C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) CMIP KIAA1694 TCMIP Homo sapiens (Human) in utero embryonic development [GO:0001701] cytosol [GO:0005829]; nucleoplasm [GO:0005654] FTKELKYVIQR;LSADTYEDLK;VLSNPSRWEVVLKEIR 3 4.8 0.87634 -0.13222 0 0 0 0 0 0 0 0 8.2954 8.9782 0 7.2181 Q8IY26 PLPP6_HUMAN Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) PLPP6 PDP1 PPAPDC2 Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; innate immune response [GO:0045087]; isoprenoid metabolic process [GO:0006720]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]; protein prenylation [GO:0018342] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] hydrolase activity [GO:0016787]; isoprenoid diphosphate phosphatase activity [GO:0106405]; lipid phosphatase activity [GO:0042577]; lyase activity [GO:0016829]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] FILNHLVLAIPLRVLVVLWAFVLGLSR 1 9.2 0.83972 -0.045996 0 0 0 0 0 0 0 4.87106 0 0 0 0 Q8IY33 MILK2_HUMAN MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) MICALL2 JRAB Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; positive regulation of protein targeting to mitochondrion [GO:1903955]; substrate adhesion-dependent cell spreading [GO:0034446] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; actinin binding [GO:0042805]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] AGEAPRK;AGSCRTQEPR 2 3.4 0.96694 -1.3107 0 0 0 0 5.4591 0 0 0 0 0 0 0 Q8IY34 S15A3_HUMAN Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2) (hPHT2) SLC15A3 OCTP PHT2 PTR3 Homo sapiens (Human) dipeptide import across plasma membrane [GO:0140206]; innate immune response [GO:0045087]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; protein transport [GO:0015031] endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647] SNLTSFGADQVMDLGR 1 2.8 0.77812 0.038313 0 0 0 0 0 0 0 10.427 0 0 0 0 Q8IY37 DHX37_HUMAN Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) DHX37 DDX37 KIAA1517 Homo sapiens (Human) "brain development [GO:0007420]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of male gonad development [GO:2000020]; ribosomal small subunit biogenesis [GO:0042274]; ribosome assembly [GO:0042255]; ribosome biogenesis [GO:0042254]" cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U3 snoRNA binding [GO:0034511] APPLSKK;GVDASNALVLPGKK;LLIMSATLR 3 2.6 0.90798 -0.27661 0 0 0 11.5554 0 0 0 0 0 10.1135 7.57516 9.42284 Q8IY45 AMN1_HUMAN Protein AMN1 homolog AMN1 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] microvillus membrane [GO:0031528]; SCF ubiquitin ligase complex [GO:0019005] LNLNASKGNRVSVTSEGIK 1 7.4 0.5046 0.18805 0 0 0 0 0 0 0 7.72608 0 0 0 0 Q8IY47 KBTB2_HUMAN Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) KBTBD2 BKLHD1 KIAA1489 CGI-73 Homo sapiens (Human) gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of cellular response to insulin stimulus [GO:1900076]; response to insulin [GO:0032868] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EEMMIFIEASSENPCSLYSSVCYSPQAEK;ETHLNERAK 2 6.1 0.91733 -0.35417 0 0 0 0 0 0 0 0 6.11676 0 6.83807 0 Q8IY50 S35F3_HUMAN Solute carrier family 35 member F3 (Thiamine transporter SLC35F3) SLC35F3 Homo sapiens (Human) thiamine transport [GO:0015888] membrane [GO:0016020] LLLGSAK;SIAVGMR;SPDVSPRR 3 4.5 0.97554 -1.4326 0 11.3069 0 0 0 0 8.64731 9.83925 7.84046 10.575 10.4728 0 Q8IY51 TIGD4_HUMAN Tigger transposable element-derived protein 4 TIGD4 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] IAQCLNVPVNGPMLRLKANDFAQK;LDEEFQAQQRR 2 6.8 0.95389 -0.91593 12.6659 8.49681 0 0 0 0 0 0 0 0 0 0 Q8IY57 YAF2_HUMAN YY1-associated factor 2 YAF2 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] VGGGSSEEKK 1 8.5 0.73531 0.11136 0 0 0 0 0 0 0 0 0 0 9.87595 0 Q8IY63 AMOL1_HUMAN Angiomotin-like protein 1 AMOTL1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] EKEKLEMELAAVR;HPAAKGTAEK;LEEELREK;NLHAKIIEK;QVRSTQPQQNNEELPTYEEAK;VGGGPSPAQPAGKVLDPRGPPPEYPFK;VLQQRSRK 7 10 0.97516 -4.1715 0 0 0 10.3936 8.78725 0 7.0542 0 0 11.338 9.70938 0 Q8IY67 RAVR1_HUMAN Ribonucleoprotein PTB-binding 1 (Protein raver-1) RAVER1 KIAA1978 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] ASAATTR 1 1.2 0.82378 -0.017954 0 0 0 0 0 9.38655 0 0 0 0 0 0 Q8IY81 SPB1_HUMAN pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) FTSJ3 SB92 Homo sapiens (Human) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]" "chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]" RNA 2'-O-methyltransferase activity [GO:0062105]; RNA binding [GO:0003723]; rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650] AANPVDFLSK;GVGRKVR;ILDPEGLALGAVIASSK 3 4 0.7196 0.1348 0 11.3755 0 0 0 8.30793 0 12.2175 7.44435 7.04089 10.0261 0 Q8IY82 DRC7_HUMAN Dynein regulatory complex subunit 7 (Coiled-coil domain-containing protein 135) (Coiled-coil domain-containing protein lobo homolog) DRC7 C16orf50 CCDC135 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] LTCWQAVR;YLALEEKLYKDPR 2 2.4 0.87993 -0.15401 0 0 0 0 10.7154 0 12.3677 12.192 12.445 0 0 10.9614 Q8IY84 NIM1_HUMAN Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) NIM1K NIM1 Homo sapiens (Human) protein phosphorylation [GO:0006468] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IGFYRIRGEIGSGNFSQVK;LTQDMSQDEK;LTQDMSQDEKVVR;VAIKILDKTK 4 9.6 0.97647 -2.1813 0 0 0 10.4365 8.52199 8.78895 0 0 0 0 0 10.8186 Q8IY85 EFC13_HUMAN EF-hand calcium-binding domain-containing protein 13 EFCAB13 C17orf57 Homo sapiens (Human) HSSLQKQVSSTEK;ITELTEAGETK;NGINFKKHSEK;SLDKSDISSIPK;SLSPEYKK;VVRNMRDAAR 6 6.7 0.97535 -3.592 0 0 0 8.71332 10.3188 9.76152 0 11.8922 0 0 0 11.4064 Q8IY92 SLX4_HUMAN Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) SLX4 BTBD12 KIAA1784 KIAA1987 Homo sapiens (Human) DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; positive regulation of telomere maintenance [GO:0032206]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656]; telomeric D-loop disassembly [GO:0061820] "cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]" DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] AGQCPPPPER;GSHHTSGSSLSTPR;SISSDPLEEKKALEISPR;TGQMMDESDEDFK;TLQGPAEK;VEEMEPLEPGR;VGASAHDDSLEEK 7 4.7 0.97884 -1.9188 6.44953 12.9341 14.1037 4.85793 0 0 0 9.95402 0 0 0 7.26313 Q8IY95 TM192_HUMAN Transmembrane protein 192 TMEM192 Homo sapiens (Human) endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803] HNALLSKR 1 3 0.8396 -0.043952 0 0 0 0 0 0 0 0 0 9.04903 0 0 Q8IYA2 C144C_HUMAN Putative coiled-coil domain-containing protein 144C (Coiled-coil domain-containing protein 144C pseudogene) CCDC144CP CCDC144C Homo sapiens (Human) DALGRESLILERVQR;DLSQTQCQK;EDNTTSIK;ELMDEYNHLK;ENVQLHKEVEEEMEKHR;EVEEEMEK;KETEQMYQSK;LEIDTIKNQNKQK;LEWKNQLK;NPEISHR;QILSLQEKNK;TSQADFNKTK;VDMSGLQAK;VSWGGEK;VVETKQQLKWNLR 15 11.8 0.97842 -7.3685 0 12.3561 0 10.5187 0 0 11.348 0 7.65062 9.07146 11.0426 11.6223 Q8IYA6 CKP2L_HUMAN Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis) CKAP2L Homo sapiens (Human) centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] FAKFWICK;MQKAQTLDSK;SIEKEEEEK 3 8.1 0.9734 -2.5412 0 0 10.3114 10.1533 0 0 0 0 8.85353 0 0 0 Q8IYA7 MKX_HUMAN Homeobox protein Mohawk MKX C10orf48 IRXL1 Homo sapiens (Human) cell development [GO:0048468]; muscle organ development [GO:0007517]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EINAAMALTNLAQGKDK;LSGAVLFEDGGASERER;NTVRQPDLSWALRIK;SSHIAEVKTVK 4 17 0.97697 -2.223 0 0 13.9195 0 7.37504 9.32535 0 10.0647 0 7.24907 0 0 Q8IYA8 IHO1_HUMAN Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36) IHO1 CCDC36 Homo sapiens (Human) DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283] condensed nuclear chromosome [GO:0000794] AQPLHLQCPR 1 1.7 0.91002 -0.31187 0 0 0 0 0 0 0 0 0 0 9.72054 0 Q8IYA8 IHO1_HUMAN Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36) IHO1 CCDC36 Homo sapiens (Human) DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283] condensed nuclear chromosome [GO:0000794] LWKSLRTISVQEANLFWILWR 1 10.3 0.53217 0.18665 0 0 0 0 0 6.52507 0 0 0 0 0 0 Q8IYB1 M21D2_HUMAN Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2) MB21D2 C3orf59 Homo sapiens (Human) cadherin binding [GO:0045296]; nucleotidyltransferase activity [GO:0016779]; protein-containing complex binding [GO:0044877] AIIIKLLSRPK;LHDRNQPVTLDMR 2 4.9 0.88595 -0.19607 10.5291 6.12408 0 9.68533 0 0 0 0 0 0 0 0 Q8IYB3 SRRM1_HUMAN Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) SRRM1 SRM160 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; RNA binding [GO:0003723] AKSPTPSPSPPRNSDQEGGGK;EPSPEKNSKK;LSPSASPPR;RRSPSPR;RVSRTPEPK;VSVSPGR 6 7 0.97517 -3.9773 0 12.712 0 0 10.2899 0 8.38853 6.363 11.0779 0 0 7.58999 Q8IYB4 PEX5R_HUMAN PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) PEX5L PEX5R PXR2 Homo sapiens (Human) "protein import into peroxisome matrix, docking [GO:0016560]" cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; receptor complex [GO:0043235] peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; small GTPase binding [GO:0031267] NWIKQNPK;SDLTLALGKGSR;YNLGISCINLGAYR 3 5.4 0.98054 -1.6852 0 0 0 4.42338 0 0 0 0 0 8.33119 0 0 Q8IYB4 PEX5R_HUMAN PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) PEX5L PEX5R PXR2 Homo sapiens (Human) "protein import into peroxisome matrix, docking [GO:0016560]" cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; receptor complex [GO:0043235] peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; small GTPase binding [GO:0031267] NWIKQNPK;YNLGISCINLGAYR;YQGHMQGKGSRAADK 3 6.1 0.84958 -0.079027 0 0 0 0 6.95606 0 0 0 0 0 0 0 Q8IYB7 DI3L2_HUMAN DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) DIS3L2 FAM6A Homo sapiens (Human) cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process [GO:0000956]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827] cytoplasm [GO:0005737]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540] ELPPISPEHSSEEVHQQNADK;GTLIQGVLRINPK;LLCEELCSLNPMSDK;LSVCVSEK;SAKVVYILEK;SIFETYMSK;VVYILEKK;VVYILEKKHSR 8 13.3 0.97679 -4.7716 0 8.52454 0 0 0 8.50084 0 9.5719 0 14.3283 14.3404 9.25552 Q8IYB7 DI3L2_HUMAN DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) DIS3L2 FAM6A Homo sapiens (Human) cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process [GO:0000956]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827] cytoplasm [GO:0005737]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540] GTLIQGVLRINPK;LQKMRPPAFHKTQELYR;LSVCVSEK;LSVCVSEKDNEIEAQR;LVKLSLKQK;SIFETYMSK;TQELYRRNPCK 7 19.4 0.96565 -1.2572 0 0 0 9.1698 9.64542 0 0 0 0 0 8.94775 0 Q8IYB8 SUV3_HUMAN "ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)" SUPV3L1 SUV3 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrial RNA surveillance [GO:2000827]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; RNA catabolic process [GO:0006401] mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AMQRKIIFHSGPTNSGK;EGEVTTMNHEDLSLLKEILKRPVDPIR;EKTESGTHPK;IIFYSLIKPSINEKGER;ISDLRIPPNWYPDARAMQR;NDIYSVSR;VLDKFYKR;YFSAKSGVYCGPLK 8 14.8 0.9743 -3.8314 0 0 0 0 10.9989 6.32869 11.1441 4.17105 13.2076 0 0 10.9379 Q8IYD2 KLD8A_HUMAN Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1) KLHDC8A Homo sapiens (Human) AGVAVTALGKRIMVIGGVGTNQLPLK;LYRQPKFLR;YAATSFLRGSK 3 13.1 0.89578 -0.22818 5.98691 0 12.3727 0 11.7833 9.99308 0 11.8607 11.6055 12.3332 11.4513 12.2709 Q8IYD8 FANCM_HUMAN Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) FANCM KIAA1596 Homo sapiens (Human) double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of protein monoubiquitination [GO:1902527]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; nuclease activity [GO:0004518]; RNA helicase activity [GO:0003724] EIWCSKRVLFLTPQVMVNDLSR;ELSLVEQRK;GFTQKEQLEVVKQFR;RESNIAVNPSTVK;TDDQFYNCHSLTK 5 3.5 0.073836 0.40864 0 9.70344 10.0008 0 0 0 4.54331 0 0 9.61561 0 0 Q8IYD9 LAS2_HUMAN Lung adenoma susceptibility protein 2 LAS2 C18orf54 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285] extracellular region [GO:0005576] FNQNKTTDPK;GRLGSLDIEK;NLEQCTEELPK 3 8.3 0.97489 -3.2013 0 0 12.1817 0 0 0 0 0 0 0 0 10.6425 Q8IYE0 CC146_HUMAN Coiled-coil domain-containing protein 146 CCDC146 KIAA1505 Homo sapiens (Human) cell morphogenesis [GO:0000902]; gene expression [GO:0010467]; manchette assembly [GO:1905198]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; spermatid development [GO:0007286] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; midbody [GO:0030496]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212] protein-containing complex binding [GO:0044877] EFHNQYRLNSLK 1 1.3 0.88752 -0.18563 0 0 0 5.5771 0 0 0 0 0 0 0 0 Q8IYE1 CCD13_HUMAN Coiled-coil domain-containing protein 13 CCDC13 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; non-motile cilium assembly [GO:1905515] cell projection [GO:0042995]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] IVELSKK;LLESERKLQEER;NKLLSSEMK;VEESNSK 4 4.9 0.97427 -1.4241 11.2755 0 0 0 8.91319 6.15255 0 0 0 7.79253 0 0 Q8IYF1 ELOA2_HUMAN Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII subunit A2) (Transcription elongation factor B polypeptide 3B) ELOA2 TCEB3B TCEB3L Homo sapiens (Human) regulation of DNA-templated transcription elongation [GO:0032784]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368] elongin complex [GO:0070449]; nucleoplasm [GO:0005654] DLAARWK;EQYLRLPDAPEQRLR;LPDAPEQRLR;VAPLMAK;YLTYDQLRKQK 5 5.3 0.97482 -3.2676 0 0 0 8.27589 0 0 0 10.2269 0 0 5.2213 12.7354 Q8IYF3 TEX11_HUMAN Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) TEX11 ZIP4 Homo sapiens (Human) apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; male gonad development [GO:0008584]; male meiosis chromosome segregation [GO:0007060]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694] EAVAEAERHDPR;KALLLYK;LIMMNMRIGK;LLLLYEFEVRAK;LSQPFGEEALSLESR;SWNTGVLMFSR 6 7.1 0.97852 -2.1265 0 11.722 0 0 0 0 0 0 0 10.2906 11.8834 6.97774 Q8IYG6 LRC56_HUMAN Leucine-rich repeat-containing protein 56 LRRC56 Homo sapiens (Human) cell projection organization [GO:0030030] cilium [GO:0005929] ALEVASR;RHQCQAR;TLEMCVDTR;YLQLCPR 4 5.5 0.97375 -1.4098 0 8.77804 13.1027 0 9.0964 0 0 0 0 0 8.94518 0 Q8IYH5 ZZZ3_HUMAN ZZ-type zinc finger-containing protein 3 ZZZ3 Homo sapiens (Human) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] LVFDKVGLPARPK;VPCTDSQVQVKLEDHK 2 3.2 0.9213 -0.44604 0 0 0 0 0 0 0 0 4.01855 0 0 0 Q8IYH5 ZZZ3_HUMAN ZZ-type zinc finger-containing protein 3 ZZZ3 Homo sapiens (Human) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] LVFDKGLPARPKSPLDPK;VPCTDSQVQVKLEDHK 2 3.8 0.86698 -0.092894 0 3.99476 0 0 0 0 0 0 8.11207 0 0 8.42034 Q8IYI6 EXOC8_HUMAN Exocyst complex component 8 (Exocyst complex 84 kDa subunit) EXOC8 Homo sapiens (Human) endosome organization [GO:0007032]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cell leading edge [GO:0031252]; cytosol [GO:0005829]; exocyst [GO:0000145]; growth cone [GO:0030426]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267] CEQDPEK;LGQCTKACELFLR;RFEEGVGKPAK;SAMGMFVDAFSKQVFDSK 4 6.8 0.97625 -1.4661 0 0 0 0 7.5539 0 0 8.86614 0 0 0 0 Q8IYJ1 CPNE9_HUMAN Copine-9 (Copine IX) CPNE9 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] AVGEIIQDYDSDK;DIVQFVPFRDYVDR 2 4.9 0.94547 -0.64259 0 0 0 0 10.1297 0 0 0 9.1074 0 0 0 Q8IYJ2 CJ067_HUMAN "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) mitochondrion [GO:0005739] LREELHYEKSLVQDVINK;MPKKALK;SLVQDVINK;SWEKRFFILR 4 6.4 0.97594 -1.4745 10.6263 12.1341 0 5.82909 0 0 0 0 0 0 0 0 Q8IYJ3 SYTL1_HUMAN Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) SYTL1 SLP1 SB146 Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267] DLLPLRAGSLDTYVQCFVLPDDSQASR;QLEEGRVSK 2 6.4 0.77122 0.054571 0 6.49558 17.9153 14.4892 0 0 0 0 0 18.1677 18.4687 0 Q8IYK8 REM2_HUMAN GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) REM2 Homo sapiens (Human) plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] FLANLVPR;LLAELDR 2 4.4 0.95442 -0.90847 0 0 0 0 11.2718 0 0 0 0 9.77668 0 0 Q8IYK8 REM2_HUMAN GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) REM2 Homo sapiens (Human) plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DPTSAPGWEAAPRPTRYPRWK;LLAELDR 2 12.7 0.50546 0.18816 0 0 0 0 0 0 0 6.23496 0 0 0 0 Q8IYL2 TRM44_HUMAN Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) TRMT44 C4orf23 METTL19 Homo sapiens (Human) tRNA methylation [GO:0030488] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; tRNA (uridine) methyltransferase activity [GO:0016300]; tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity [GO:0141101] EASVDEKR;RGCPVSPPGWELSPSPR;TYPSSREASVDEK 3 4.1 0.94113 -0.60131 0 0 6.74443 0 0 0 0 0 0 0 8.25427 0 Q8IYL3 CA174_HUMAN UPF0688 protein C1orf174 C1orf174 Homo sapiens (Human) nucleoplasm [GO:0005654] AKDDDDDDDDDAEM;MHFRAKDDDDDDDDDAEM 2 7.4 0.71231 0.15231 0 0 3.82171 0 5.29149 6.08674 0 0 0 0 5.75208 0 Q8IYL9 PSYR_HUMAN Psychosine receptor (G-protein coupled receptor 65) (T-cell death-associated gene 8 protein) GPR65 TDAG8 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic process [GO:0006915]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of stress fiber assembly [GO:0051496]; response to acidic pH [GO:0010447] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ATENKEK;ILSVSTKDTMELEVLE 2 6.8 0.9785 -2.0863 0 0 0 0 0 0 11.9132 0 0 0 0 10.6583 Q8IYM0 F186B_HUMAN Protein FAM186B FAM186B C12orf25 Homo sapiens (Human) protein-containing complex [GO:0032991] ACVPLQMAR;IEAAQLTR;IFTPTSR;LQYLCHK 4 3.5 0.98092 -1.6885 11.777 0 0 0 0 0 0 0 0 0 9.03738 0 Q8IYM1 SEP12_HUMAN Septin-12 SEPTIN12 SEPT12 Homo sapiens (Human) cell differentiation [GO:0030154]; cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; spermatogenesis [GO:0007283] cell division site [GO:0032153]; cleavage furrow [GO:0032154]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803] LCRTVNVVPVIAR 1 3.6 0.98228 -1.5854 0 0 0 0 0 0 0 0 0 0 0 8.30939 Q8IYM9 TRI22_HUMAN E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) TRIM22 RNF94 STAF50 Homo sapiens (Human) defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to virus [GO:0009615] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DVCEHHGKK;DVCEHHGKKLQIFCK 2 3 0.8977 -0.24007 0 0 4.62527 0 0 0 8.48329 0 0 0 0 0 Q8IYP9 ZDH23_HUMAN Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) ZDHHC23 Homo sapiens (Human) protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] protein-cysteine S-palmitoyltransferase activity [GO:0019706] NHVATCLCDCQDLDEGCDR 1 4.6 0.78321 0.020852 0 0 0 4.20124 0 0 0 0 0 0 0 0 Q8IYQ7 THNS1_HUMAN Threonine synthase-like 1 (TSH1) THNSL1 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] LQDVGNEQFLEEEGK 1 2 0.0088106 1.0951 0 0 0 0 0 0 0 0 2.52165 0 0 13.2979 Q8IYR0 CF206_HUMAN Cilia- and flagella-associated protein 206 CFAP206 C6orf165 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; radial spoke [GO:0001534] VMQCHLNGATVKTDVCR 1 2.7 0.91807 -0.43547 0 0 0 0 0 0 0 0 0 0 2.32662 0 Q8IYR2 SMYD4_HUMAN SET and MYND domain-containing protein 4 (EC 2.1.1.-) SMYD4 KIAA1936 Homo sapiens (Human) heart development [GO:0007507]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] DIFLHSSSLLQPEDELFLK 1 2.4 0.60734 0.17637 0 0 0 0 0 0 7.34412 0 0 0 0 0 Q8IYS0 ASTRC_HUMAN Protein Aster-C (GRAM domain-containing protein 1C) GRAMD1C UNQ2543/PRO6095 Homo sapiens (Human) cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] DQAHRLK;LIADYACALQR;NEYLSLDK 3 3.9 0.97258 -2.7349 11.1197 0 0 9.59653 0 0 0 0 0 0 0 0 Q8IYS2 K2013_HUMAN Uncharacterized protein KIAA2013 KIAA2013 Homo sapiens (Human) membrane [GO:0016020] VGDHQFLLYSGRSPPTPTGLVHLVVVAAK 1 4.6 0.8412 -0.051328 0 0 0 0 6.30597 0 0 0 0 0 0 0 Q8IYS4 DAAF8_HUMAN Dynein axonemal assembly factor 8 (Dynein axonemal-associated protein 1) DNAAF8 C16orf71 DAAP1 Homo sapiens (Human) outer dynein arm assembly [GO:0036158] dynein axonemal particle [GO:0120293] dynein complex binding [GO:0070840] APGTVWWAADHRQVQDR;DACGPTSSDK;GTAQPELPASKGPAGGR 3 8.5 0.96669 -1.2863 0 0 0 9.16428 0 0 0 9.84789 0 0 7.29398 0 Q8IYS8 BD1L2_HUMAN Biorientation of chromosomes in cell division protein 1-like 2 (Biorientation of chromosomes in cell division protein 1 pseudogene) (Protein FAM44C) BOD1L2 BOD1P FAM44C Homo sapiens (Human) cell division [GO:0051301] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776] ADVDTKPAYQNLSQK 1 8.7 0.78325 0.02849 0 0 0 0 0 0 0 0 0 8.29076 0 0 Q8IYT1 GAR4_HUMAN Golgi-associated RAB2 interactor protein 4 (Golgi-associated Rab2B interactor-like 4) (GARI-L4) (GARI-like 4) GARIN4 FAM71A Homo sapiens (Human) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; nucleus [GO:0005634] ISVQDHEK;ISVQDHEKQQLR;QLYKGEYDIFK;QSKSSLSGQHGRER;VAVAGAAGK 5 7.7 0.9802 -1.8279 0 0 0 0 9.62363 0 0 9.60086 0 0 0 3.31129 Q8IYT2 CMTR2_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) CMTR2 AFT FTSJD1 Homo sapiens (Human) 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483] AGKIISHVR;KALFPHHVIPDSFLKR 2 3.2 0.96367 -1.1877 0 0 0 0 0 0 0 0 0 0 0 8.78339 Q8IYT3 CC170_HUMAN Coiled-coil domain-containing protein 170 CCDC170 C6orf97 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226] cell junction [GO:0030054]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794] microtubule binding [GO:0008017] DCLDPDER;EVKIFQERLLAGQQVWDASK;IAQLEEEK;KVVELNEK;SLEEAEKR;SLEEAEKREK 6 7.6 0.97464 -3.6231 12.1054 0 0 0 9.61688 10.9277 0 0 0 0 6.89954 11.7231 Q8IYT4 KATL2_HUMAN Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2) KATNAL2 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013] cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] GLLLYGPPGTGK;LVRVLFELAR;SKTTAGK;VLFELAR;YPQLFTGILSPWK 5 7.8 0.022599 0.62091 0 12.2655 0 9.29877 0 0 11.6847 11.6295 11.9105 7.25465 0 11.906 Q8IYT8 ULK2_HUMAN Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) ULK2 KIAA0623 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axon extension [GO:0048675]; axon guidance [GO:0007411]; collateral sprouting [GO:0048668]; mitophagy [GO:0000423]; negative regulation of collateral sprouting [GO:0048671]; piecemeal microautophagy of the nucleus [GO:0034727]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]; somatic sensory system development [GO:0160038] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FCITMCKKLTEK;HLGSSPR;LQSAPTLTDIYQNKQKLR;LSDQQGK;QVVKNLNER;YKCSIERR 6 5.9 0.97567 -5.0731 0 0 0 10.1572 9.18589 9.13525 0 0 0 0 10.6155 0 Q8IYU2 HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HACE1 KIAA1320 Homo sapiens (Human) Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nuclear body [GO:0016604]; nucleus [GO:0005634] small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] FIEFVCKHDEVLK 1 1.4 0.92156 -0.44294 0 10.8019 0 0 0 0 0 11.3245 0 0 0 0 Q8IYU4 UBQLN_HUMAN Ubiquilin-like protein UBQLNL Homo sapiens (Human) ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] polyubiquitin modification-dependent protein binding [GO:0031593] SLAHSFRDLPTNDPCHR 1 6.5 0.8113 -0.014435 0 0 0 0 0 0 0 0 0 9.45127 0 0 Q8IYW2 CFA46_HUMAN Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] axoneme [GO:0005930] ALEMGIK;DLVITQELAR;GLSDLYHLRLAHACSELKLR;HFPLEDVVFHLR;LDSLGLYRDRIQMASTR;LIEMECLECESEALRLESK;LINAFKILKK;VQTPAVVADSGKSKGK;VSTGKNR 9 4.3 0.97546 -3.5729 6.11491 11.9641 0 9.87584 0 8.34877 10.6798 9.50216 9.25569 0 0 5.65329 Q8IYW2 CFA46_HUMAN Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] axoneme [GO:0005930] DLVITQELAR;QIFSVMVNQR 2 8.1 0.93313 -0.49547 0 0 0 0 0 0 0 0 0 0 0 10.9239 Q8IYW4 ENTD1_HUMAN ENTH domain-containing protein 1 (Epsin-2B) ENTHD1 Homo sapiens (Human) endocytosis [GO:0006897] clathrin vesicle coat [GO:0030125]; endosome [GO:0005768]; plasma membrane [GO:0005886] clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] NFVKNYSDAEIK;SKQVITLLMDEPLLCK 2 4.6 0.9419 -0.61837 0 0 0 0 7.53403 0 0 0 0 0 9.28808 0 Q8IYW5 RN168_HUMAN E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) RNF168 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2AK15 ubiquitin ligase activity [GO:0140858]; histone ubiquitin ligase activity [GO:0140852]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] SDPVTPKSEK;VSSWTRYHTR 2 3.5 0.95539 -0.97125 0 11.7139 0 0 0 0 0 0 0 0 0 0 Q8IYX1 TBC21_HUMAN TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein) TBC1D21 MGCRABGAP Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; sperm midpiece [GO:0097225] actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] LTVDSMR;LTVDSMRRK 2 3 0.94074 -0.58765 11.0181 0 0 9.1917 0 0 0 0 0 0 0 0 Q8IYX3 CC116_HUMAN Coiled-coil domain-containing protein 116 CCDC116 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737] GSLTHHS 1 1.3 0.90908 -0.317 0 0 0 0 0 0 0 0 6.88679 0 0 0 Q8IYX4 DND1_HUMAN "Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)" DND1 RBMS4 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; germ cell development [GO:0007281]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729] AAAMAKK;LVQVNGQRK 2 4.5 0.91296 -0.38851 0 0 0 0 0 0 0 10.8231 0 0 0 0 Q8IYX7 SAXO1_HUMAN Stabilizer of axonemal microtubules 1 SAXO1 C9orf138 FAM154A Homo sapiens (Human) cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821] axonemal microtubule [GO:0005879]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] APITYVPPEDR;VDPIKPR 2 3.8 0.93567 -0.52756 15.8594 16.1558 0 12.3282 0 11.6534 0 0 0 0 7.30424 9.29786 Q8IYX8 CE57L_HUMAN Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein) CEP57L1 C6orf182 CEP57R Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] HLEEKLKEEEHQR;TLQEKIHRLELER 2 5.7 0.95397 -0.89338 0 0 0 10.1695 0 0 0 0 0 10.0965 0 0 Q8IYY4 DZI1L_HUMAN Cilium assembly protein DZIP1L (DAZ-interacting zinc finger protein 1-like) DZIP1L Homo sapiens (Human) ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; floor plate development [GO:0033504]; neural tube patterning [GO:0021532]; protein localization to cilium [GO:0061512]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224] axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] metal ion binding [GO:0046872] EVTSRAKER;GISIQTLRHLESLLR;LYGEIDK;MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWR;TLQVALPSTPAEPPPPTR 5 11.1 0.97458 -3.0975 0 8.75452 0 0 5.45891 0 4.7105 0 0 0 0 0 Q8IZ07 AN13A_HUMAN Ankyrin repeat domain-containing protein 13A (Protein KE03) ANKRD13A ANKRD13 Homo sapiens (Human) negative regulation of protein localization to endosome [GO:1905667]; negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] AEVVNGYEAKVYTVNNVNVITKIR 1 4.1 0.62123 0.1736 0 0 0 0 0 0 0 0 0 0 0 11.4606 Q8IZ21 PHAR4_HUMAN Phosphatase and actin regulator 4 PHACTR4 PRO2963 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of catalytic activity [GO:0043085]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542] HFTRYHRP;SSDKFKETSEVLER 2 3.1 0.97512 -1.4454 11.1438 0 0 0 0 0 0 0 0 0 0 0 Q8IZ40 RCOR2_HUMAN REST corepressor 2 RCOR2 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667] enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] EDSDELEEGR;ELKGMLVWSPNHCVSDAKLDK;QTNSSLR;QVQSMKQTNSSLR;TLTQVKTFFVSYRR 5 11.1 0.97279 -1.3738 0 8.20897 2.85943 0 0 8.66035 0 0 8.55348 0 7.6879 12.0454 Q8IZ41 RASEF_HUMAN Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) RASEF RAB45 Homo sapiens (Human) vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] SFSSQKAYK;SLHINNISPGNTISRSSPK;SPQMKNCCNG 3 5.1 0.97448 -2.4389 0 0 10.8943 0 0 0 6.40667 0 0 0 0 0 Q8IZ41 RASEF_HUMAN Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) RASEF RAB45 Homo sapiens (Human) vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] EGRETLWTIEEGGAK 1 7.9 0.98021 -1.5995 0 0 0 9.01408 0 0 0 0 0 0 0 0 Q8IZ52 CHSS2_HUMAN Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2) CHPF CSS2 UNQ651/PRO1281 Homo sapiens (Human) "chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]" cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; mitochondrial matrix [GO:0005759] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] LLVAVLTSQTTLPTLGVAVNRTLGHRLER;SALTAHPVR 2 4.9 0.93378 -0.51073 0 0 0 0 0 0 0 0 0 6.89857 0 0 Q8IZ57 NRSN1_HUMAN Neurensin-1 (Neuro-p24) (Vesicular membrane protein of 24 kDa) (Vesicular membrane protein p24) NRSN1 VMP Homo sapiens (Human) nervous system development [GO:0007399] cytoplasmic vesicle [GO:0031410]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133] QAQAAAEGGYQRYGVR 1 8.2 0.88198 -0.16295 0 0 0 0 0 0 0 0 9.981 0 0 0 Q8IZ69 TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) TRMT2A Homo sapiens (Human) methylation [GO:0032259]; mRNA processing [GO:0006397]; tRNA processing [GO:0008033] cytosol [GO:0005829] "C-methyltransferase activity [GO:0008169]; RNA binding [GO:0003723]; tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [GO:0030697]" HASFSDVRRFLGR;LLYVSCNPR 2 3.5 0.98084 -1.7427 0 0 0 0 0 0 0 0 0 0 0 11.9742 Q8IZ73 RUSD2_HUMAN Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) RPUSD2 C15orf19 Homo sapiens (Human) enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] GRGGYIPKTNEELLR 1 2.8 0.67501 0.16656 0 0 0 0 0 0 9.58404 0 0 0 0 0 Q8IZ81 ELMD2_HUMAN ELMO domain-containing protein 2 ELMOD2 Homo sapiens (Human) defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688] membrane [GO:0016020] GTPase activator activity [GO:0005096] QLYLDVESVR 1 3.4 0.93559 -0.52823 0 0 0 0 10.0024 0 0 0 0 0 0 0 Q8IZ83 A16A1_HUMAN Aldehyde dehydrogenase family 16 member A1 ALDH16A1 Homo sapiens (Human) membrane [GO:0016020] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AATRAGPR;DPSVPTGGCK 2 2.2 0.93856 -0.57229 0 0 7.02436 0 0 0 9.28774 0 0 0 0 0 Q8IZ96 CKLF1_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 1 (Chemokine-like factor superfamily member 1) CMTM1 CKLFSF1 Homo sapiens (Human) chemotaxis [GO:0006935] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125] MDPEHAKLTLHHLLTYLHRPLLAAELSLSHR 1 68.9 0.92771 -0.45692 0 0 10.5132 0 0 0 0 0 0 0 0 0 Q8IZ96 CKLF1_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 1 (Chemokine-like factor superfamily member 1) CMTM1 CKLFSF1 Homo sapiens (Human) chemotaxis [GO:0006935] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125] LLNEMAIKERVEGR 1 4.9 0.93861 -0.57338 0 0 0 0 0 0 10.0326 0 0 8.36234 0 12.0184 Q8IZA0 K319L_HUMAN Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR) KIAA0319L AAVR KIAA1837 PP791 Homo sapiens (Human) neuron migration [GO:0001764] cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] IVQYHWEELK 1 1 0.93584 -0.53627 0 0 0 0 0 0 10.8478 0 0 0 0 0 Q8IZA3 H18_HUMAN Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1) H1-8 H1FOO H1OO OSH1 Homo sapiens (Human) chromosome condensation [GO:0030261]; epigenetic regulation of gene expression [GO:0040029]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527] GLLARPLNSKAR 1 3.5 0.98026 -1.6507 0 0 0 8.3689 0 0 0 0 0 0 0 0 Q8IZC4 RTKN2_HUMAN Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) RTKN2 PLEKHK1 Homo sapiens (Human) hemopoiesis [GO:0030097]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] IEIMSPR;LESLTDIIQK;LYCFYSPEEIEAK;NLMVCNAR 4 6.2 0.97983 -1.8228 8.41587 7.19042 0 0 0 0 0 0 0 0 11.412 0 Q8IZC6 CORA1_HUMAN Collagen alpha-1(XXVII) chain COL27A1 KIAA1870 Homo sapiens (Human) angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage chondrocyte development [GO:0003431]; notochord development [GO:0030903]; skeletal system development [GO:0001501] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] AHDGAKGDMGLPGLSGNPGPPGRK;SPHPTQK;TGAKGAK 3 2 0.87974 -0.14516 9.54591 0 0 0 0 7.00899 0 0 0 9.1185 0 0 Q8IZC7 ZN101_HUMAN Zinc finger protein 101 (Zinc finger protein HZF12) ZNF101 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFGWCSSLRR;LSCSSSLHR;MRAHAGHKR;TVTPTRKRPYECK 4 13 0.95484 -0.89973 10.1026 0 11.651 9.96081 0 0 0 0 0 0 9.71961 10.8647 Q8IZD0 SAM14_HUMAN Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) SAMD14 Homo sapiens (Human) actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; neuron projection development [GO:0031175] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015] QVDGPQLLQLDGSK 1 3.4 0.78408 0.019493 8.65285 0 0 0 0 0 0 0 0 0 0 0 Q8IZD2 KMT2E_HUMAN Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) KMT2E MLL5 Homo sapiens (Human) epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967] enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713] CICGFTHDDGYMICCDK;ENPECPVLKR;GTMYSSWVK;MTREERK;SPETKQR;VLIQLYHR 6 3.5 0.9722 -2.8291 0 8.77804 0 0 8.05409 7.79883 0 0 9.12497 11.7166 12.3512 5.76142 Q8IZD4 DCP1B_HUMAN mRNA-decapping enzyme 1B (EC 3.6.1.62) DCP1B Homo sapiens (Human) "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729] DEYTKCK;GVQNASR;TCSEPKK 3 3.4 0.95763 -1.0201 0 0 0 0 0 0 0 0 10.4342 0 0 5.87172 Q8IZD9 DOCK3_HUMAN Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) DOCK3 KIAA0299 MOCA Homo sapiens (Human) neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] HPGDAEK;IIHYFNKGKSWEFGIPLCR;ILLPVVLHHIHLHLR;LEPEFFR;LFGFAFSTLMR;NIMIPIFHDMMDWEQRKNGNFK;QDHIQEAMRALEYLFK 7 4.8 0.98019 -1.5643 12.5431 0 0 0 9.98485 8.29971 0 0 0 0 0 0 Q8IZE3 PACE1_HUMAN Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) SCYL3 PACE1 Homo sapiens (Human) cell migration [GO:0016477]; inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; spinal cord motor neuron differentiation [GO:0021522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027] ATP binding [GO:0005524]; identical protein binding [GO:0042802] SLTLKSEEEK;SSLPQKISLVQR 2 3 0.94429 -0.62936 0 0 9.8157 0 0 0 0 5.96509 0 0 0 0 Q8IZF0 NALCN_HUMAN Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1) NALCN VGCNL1 Homo sapiens (Human) "calcium ion transmembrane transport [GO:0070588]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; potassium ion transmembrane transport [GO:0071805]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725]" monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] leak channel activity [GO:0022840]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; voltage-gated sodium channel activity [GO:0005248] AIDSFPRWR;APACLQK;EQLEYTIEEEVAK;LEVDLDKDK;VKFLLRLLR 5 2.7 0.98013 -1.8292 0 12.7467 12.7304 9.5775 2.55299 8.76059 10.5786 12.2181 11.3855 0 10.8143 0 Q8IZF2 AGRF5_HUMAN Adhesion G protein-coupled receptor F5 (G-protein coupled receptor 116) ADGRF5 GPR116 KIAA0758 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular filtration [GO:0003094]; glucose homeostasis [GO:0042593]; macrophage activation [GO:0042116]; negative regulation of macrophage activation [GO:0043031]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipid biosynthetic process [GO:0008654]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of lipid metabolic process [GO:0019216]; surfactant homeostasis [GO:0043129] apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ALLAFAIPALIIVVVNITITIVVITK;ERCLHNLICQER;ILRPSIGDKPCKQEK;LILDIFEYECK;NRTSYMR 5 5.3 0.97606 -2.3373 9.82085 9.71691 0 0 0 0 0 0 12.507 0 5.02188 8.97548 Q8IZF3 AGRF4_HUMAN Adhesion G protein-coupled receptor F4 (G-protein coupled receptor 115) (G-protein coupled receptor PGR18) ADGRF4 GPR115 PGR18 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] ALLIIYGILVIFR;ALLIIYGILVIFRR;LQEIILTFEKINK 3 3.9 0.084772 0.38994 4.73227 0 4.24869 0 0 6.58534 0 0 8.26529 0 9.17852 6.60326 Q8IZF6 AGRG4_HUMAN Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112) ADGRG4 GPR112 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DLYGTLSPTTPFCWIK 1 0.5 0.6011 0.17724 0 0 0 0 0 0 8.97808 9.1609 0 0 0 0 Q8IZH2 XRN1_HUMAN 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) XRN1 SEP1 Homo sapiens (Human) cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075] cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886] 5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] ALYFCGFPTLK;DAEFCLFDRVVNVR;EECKSPKAECWSQK;IEEEVEKCKQR;LHEHLKYFVNMK;LPTSALVNLSHGSRSETGNQK;SVFVNWPHLEEAR 7 5.6 0.97572 -4.353 7.31642 0 0 0 9.74275 0 10.6595 11.4031 0 10.0893 8.77525 9.66651 Q8IZJ1 UNC5B_HUMAN Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) UNC5B P53RDL1 UNC5H2 UNQ1883/PRO4326 Homo sapiens (Human) angiogenesis [GO:0001525]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] membrane raft [GO:0045121]; plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] AFPATQIYFK;NKPVELR;TLGGYLVEEPKPLMFK 3 3.5 0.97153 -1.355 0 0 0 0 0 0 0 0 0 0 0 9.23125 Q8IZJ3 CPMD8_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) eye development [GO:0001654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] ALAYGDTNCCRDGR;EDGPFWWAGLTAQRR;FDVAVRAHNDAR;GSCVCVAAVDKSVYLLR;LEAYILDPR;MSGALLWPLLPLLLLLLSARDGVR;SFEVQKYVLPK;SGALLWPLLPLLLLLLSARDGVR;TFWISWR 9 5.8 0.97664 -2.2778 0 0 0 0 0 6.06669 0 4.39259 9.99845 9.22944 11.7618 10.4946 Q8IZJ4 RGDSR_HUMAN Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4) RGL4 RGR Homo sapiens (Human) Ras protein signal transduction [GO:0007265] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] SKEVRVLQEMQLLQVAAMNYR;VQMRLRR 2 5.9 0.9738 -1.4059 10.0996 0 0 0 0 0 0 0 0 11.8339 0 0 Q8IZK6 MCLN2_HUMAN Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2) MCOLN2 Homo sapiens (Human) adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; innate immune response [GO:0045087]; macrophage migration [GO:1905517]; neutrophil migration [GO:1990266]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; protein transport [GO:0015031] late endosome membrane [GO:0031902]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; iron ion transmembrane transporter activity [GO:0005381]; NAADP-sensitive calcium-release channel activity [GO:0072345] LGLQILKIVMVTTQLVR;NSSFFRLEFYRLLQVEISFHLK;QIPWKLGLQILKIVMVTTQLVR;VCKQHYKK 4 9.2 0.96525 -1.1382 0 0 0 8.51834 0 10.4699 8.25526 9.85652 0 0 0 0 Q8IZL8 PELP1_HUMAN "Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)" PELP1 HMX3 MNAR Homo sapiens (Human) cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; euchromatin [GO:0000791]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; SUMO binding [GO:0032183] AAAVLSGPSAGSAAGVPGGTGGLSAVSSGPR;LLPGPENHR;LLRFGILIGRLLPQVLNSWSIGR;LRLLLLESVSGLLQPR;YAAQLPALFR 5 7.9 0 5.5144 13.4301 0 0 0 0 0 3.27907 0 0 0 9.02378 0 Q8IZM0 CNG1O_HUMAN Putative CNGA1-overlapping antisense gene protein (Anti-CNG1) Homo sapiens (Human) MDSYSAK 1 8.6 0.91175 -0.32339 0 0 0 0 0 0 6.12906 0 0 0 0 0 Q8IZM8 ZN654_HUMAN Zinc finger protein 654 (Melanoma-associated antigen) ZNF654 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] HRCMLCNK;QTVMKWSK;RYGNVNLELVTRIIR;VDHNVPRHR;VRFELLPILKK 5 4.3 0.9759 -4.3479 0 0 0 10.4897 9.2452 0 0 0 0 3.56973 3.25323 0 Q8IZM9 S38A6_HUMAN Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1) SLC38A6 NAT1 SNAT6 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; glutamine transport [GO:0006868] plasma membrane [GO:0005886]; synapse [GO:0045202] L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamine transmembrane transporter activity [GO:0015186] HFLITLALNIIIVLLAIYVPDIR 1 4.4 0.70162 0.16126 0 0 11.0679 0 5.41883 0 0 5.5325 0 0 0 0 Q8IZN3 ZDH14_HUMAN Palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) ZDHHC14 Homo sapiens (Human) peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] EVIINGQTVKLKYCFTCK;SQQTGFLNALK 2 5.9 0.8406 -0.040797 0 12.0855 0 0 0 0 0 0 0 0 0 10.5448 Q8IZP6 R113B_HUMAN RING finger protein 113B (Zinc finger protein 183-like 1) RNF113B RNF161 ZNF183L1 Homo sapiens (Human) snoRNA splicing [GO:0034247] U2-type spliceosomal complex [GO:0005684] metal ion binding [GO:0046872] GEEAAPESLDVVYR 1 4.3 0.78422 0.020412 0 0 0 0 0 0 0 0 0 0 8.51629 0 Q8IZP7 H6ST3_HUMAN Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST-3) (EC 2.8.2.-) HS6ST3 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi apparatus [GO:0005794]; membrane [GO:0016020] heparan sulfate 6-O-sulfotransferase activity [GO:0017095] AGQKKCTCHRPGK;DLFQQRYHHTK;NHSHTRNFYYITMLRDPVSR 3 9.3 0.88656 -0.19387 0 0 0 0 0 8.92671 0 9.66998 6.31946 0 0 0 Q8IZP9 AGRG2_HUMAN Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) ADGRG2 GPR64 HE6 TM7LN2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; spermatogenesis [GO:0007283] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EDSCNGK;TSKRGSLHFIEQM 2 2 0.97237 -1.3642 0 12.5791 6.30796 10.4519 0 10.662 0 0 0 9.51343 9.44841 0 Q8IZQ1 WDFY3_HUMAN WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) WDFY3 KIAA0993 Homo sapiens (Human) aggrephagy [GO:0035973] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; PML body [GO:0016605] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] AVSYDSKEYYMR;EPVGQIVCTDK;HHCRNCGQLFCQK;LFTELCHPPRHMTQK;LGDVILPPWAKGDPR;LLDILLKLIYTSK;LLEEGEK;QGPSQLK;RGLLQKVFVQILVK;TEIQYEK;TEIQYEKLADAVR;TLLKFTRHDYIFK;WMLEMTEGPCRMRK 13 4.2 0.97549 -4.3806 15.2604 12.4362 7.65728 8.31673 0 0 10.9757 7.88222 0 0 9.7676 4.10148 Q8IZS6 DYLT2_HUMAN Dynein light chain Tctex-type protein 2 (T-complex testis-specific protein 3) (T-complex-associated testis-expressed protein 3) (Tcte-3) (Tctex1 domain-containing protein 3) DYNLT2 TCTE3 TCTEX1D3 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874] dynein intermediate chain binding [GO:0045505] SALAKLK;YKFIIKVLFIQK 2 9.6 0.96517 -1.121 11.4298 11.0301 9.98868 0 7.16219 0 0 0 0 0 0 0 Q8IZS7 CLCL1_HUMAN Putative C-type lectin-like domain family 1 (C-type lectin-like domain family 1 pseudogene) (Dendritic cell-associated lectin 1) (DC-associated lectin-1) (DCAL-1) CLECL1P CLECL1 DCAL1 Homo sapiens (Human) B cell adhesion [GO:0097323]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of T cell proliferation [GO:0042102] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] SVSFNFSTVHK;VHKGKCYWIAETK 2 14.4 0.94782 -0.66339 0 0 11.9888 0 0 0 0 0 0 11.218 0 0 Q8IZS8 CA2D3_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3] CACNA2D3 Homo sapiens (Human) regulation of presynapse organization [GO:0099174] GABA-ergic synapse [GO:0098982]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] KYKEYEK;TVDKGKR;VRIFTYLIGR 3 2.2 0.97444 -3.7722 0 0 0 0 0 0 0 0 0 14.0073 0 0 Q8IZT6 ASPM_HUMAN Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) ASPM MCPH5 Homo sapiens (Human) asymmetric cell division [GO:0008356]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; meiotic spindle assembly [GO:0090306]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle localization [GO:0051653]; spindle organization [GO:0007051] apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634] calmodulin binding [GO:0005516] AYKTLHDTRTHFLK;CFQAQKLYK;DAEFKASKEILLAFSR;IAAQKREEYMQMR;IHFSPSEPK;IQSAFRGYNK;IRLLHFTAAAYYHLNAVR;ISYHTMR;KAAITIQSSYR;KAATCLQAAYR;MMHIAATLIQRRFR;QHKCAIIIQSYYRMHVQQK;QVYLQIRSSVIIIQAR;VSNIQNVNK;YLWATVTIQRHWR;YQALKQASVVIQQQYQANR 16 6 0.97612 -5.2048 10.1589 11.0063 9.91964 0 11.6592 6.34012 0 11.1687 12.8021 0 9.26583 8.62644 Q8IZT8 HS3S5_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5) HS3ST5 3OST5 HS3OST5 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]" Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] FYQITGRTLNWP 1 3.5 0.97355 -1.405 0 0 0 0 0 0 0 12.2601 12.4212 10.0447 0 0 Q8IZU0 FAM9B_HUMAN Protein FAM9B FAM9B TEX39B Homo sapiens (Human) meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] DQFVKALEDFEDLCDR;EEDVTDEHGER;EMKLLRDQFVK 3 17.7 0.87446 -0.10677 0 5.78367 0 0 0 0 0 0 0 6.0485 0 0 Q8IZU1 FAM9A_HUMAN Protein FAM9A FAM9A TEX39A Homo sapiens (Human) meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] nucleolus [GO:0005730]; synaptonemal complex [GO:0000795] AQLEAQVTAAQGATK;DEHTGIHTMK;EEDVTDEHGER;EPVGRKR;GLAAKREMIK;LREMKPLLEQLLKAAK 6 22.9 0.97464 -3.1011 0 7.96734 0 0 9.59057 6.66647 0 0 0 12.1176 0 0 Q8IZU2 WDR17_HUMAN WD repeat-containing protein 17 WDR17 Homo sapiens (Human) IATCSSDGFCIIR;VNPFSPLGTGIRLNPF 2 2.2 0.96663 -1.2878 4.6748 0 5.59878 0 0 0 0 0 0 0 0 0 Q8IZU3 SYCP3_HUMAN Synaptonemal complex protein 3 (SCP-3) SYCP3 SCP3 Homo sapiens (Human) cell division [GO:0051301]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286] "chromosome, centromeric region [GO:0000775]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]" DNA binding [GO:0003677] AYDFETEDK 1 3.8 0.90923 -0.31693 8.28827 0 0 0 0 0 0 0 0 0 0 0 Q8IZU8 DSEL_HUMAN Dermatan-sulfate epimerase-like protein (EC 5.1.-.-) DSEL C18orf4 NCAG1 Homo sapiens (Human) chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205] Golgi membrane [GO:0000139] chondroitin-glucuronate 5-epimerase activity [GO:0047757]; sulfotransferase activity [GO:0008146] GKLAQYFAMNKDK;IIFPFGFK;YIPYKFMNRYNGAMMDVWDAHYK 3 3.6 0.97919 -1.882 7.71053 0 0 0 0 0 9.30611 0 0 0 0 0 Q8IZV5 RDH10_HUMAN Retinol dehydrogenase 10 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 16C member 4) RDH10 SDR16C4 UNQ9375/PRO34191 Homo sapiens (Human) bud elongation involved in lung branching [GO:0060449]; ear development [GO:0043583]; embryonic camera-type eye development [GO:0031076]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; metanephros development [GO:0001656]; neural crest cell development [GO:0014032]; nose development [GO:0043584]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; primary lung bud formation [GO:0060431]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" ENVYLTAER;FLGADKCMYPFIAQR;SILPFEAVVCMYRFLGADK 3 10.9 0.91724 -0.35495 0 0 0 0 9.16345 0 0 6.82146 8.19224 4.92633 0 0 Q8IZW8 TENS4_HUMAN Tensin-4 (C-terminal tensin-like protein) TNS4 CTEN PP14434 Homo sapiens (Human) protein localization [GO:0008104] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925] actin binding [GO:0003779] EEPGAFVIR;ETRSSSESLIFSGNQGR;FVMDTSK;VTEQGITLTDVQR;VTEQGITLTDVQRKVFFR 5 7.1 0.9581 -1.0014 10.8752 10.0345 0 0 6.40982 6.60006 6.91085 0 0 0 9.96057 0 Q8IZX4 TAF1L_HUMAN Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit) TAF1L Homo sapiens (Human) male meiotic nuclear division [GO:0007140]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123] nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] AFIAAMK;DFLQVFIYRLFWKSK;FALFDEKHREEMR;FSQSTGDVDKVTDTKPR;KAFPSHSESSIR;YSFGALSQPGPHSVQPLLK 6 4.5 0.70895 0.15859 0 0 0 5.72315 0 0 0 11.3934 0 0 0 0 Q8IZY2 ABCA7_HUMAN Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter) ABCA7 Homo sapiens (Human) amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta formation [GO:0034205]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cholesterol efflux [GO:0033344]; high-density lipoprotein particle assembly [GO:0034380]; memory [GO:0007613]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of endocytosis [GO:0045806]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; plasma membrane raft organization [GO:0044857]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to nucleus [GO:0034504]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of lipid metabolic process [GO:0019216]; visual learning [GO:0008542] cell junction [GO:0030054]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor activity [GO:0034188]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548] LLQDVGLVSK;LLQMQDEGRR;LRFQLPPGGRCALAR;NLSDFLVKTYPR;SQLLPQPRVR;TLAGLGKLIATLRAAR;TLILSTHHLDEAELLGDR;TVLGGASAHRTLAGLGK;VLSRSLPLFLTLAWIYSVTLTVKAVVR;VTECLSLDK 10 6.4 0.97329 -2.4875 9.22345 0 8.55371 0 7.12402 0 0 0 9.98925 9.02497 7.88606 10.0682 Q8N0S2 SYCE1_HUMAN Synaptonemal complex central element protein 1 (Cancer/testis antigen 76) (CT76) SYCE1 C10orf94 Homo sapiens (Human) cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694]; synaptonemal complex [GO:0000795] ELDSLHGEK;VGSLEPR 2 4.6 0.95544 -0.96796 0 3.63169 0 0 3.95149 0 0 0 0 0 7.95029 0 Q8N0U7 CA087_HUMAN Uncharacterized protein C1orf87 C1orf87 Homo sapiens (Human) SFSGCLPLPKVRAICGK 1 3.1 0.97576 -1.4625 0 0 0 0 0 0 0 10.5144 0 0 0 0 Q8N0U7 CA087_HUMAN Uncharacterized protein C1orf87 C1orf87 Homo sapiens (Human) NIIAVALLMLGKNEK 1 8.3 0.9157 -0.43391 0 0 0 0 0 0 0 0 0 0 8.83498 0 Q8N0V3 RBFA_HUMAN "Putative ribosome-binding factor A, mitochondrial" RBFA C18orf22 Homo sapiens (Human) rRNA processing [GO:0006364] mitochondrion [GO:0005739] GLHCSAVSCK 1 2.9 0.79429 0.01581 0 0 0 0 0 0 0 0 0 0 4.93291 0 Q8N0V4 LGI2_HUMAN Leucine-rich repeat LGI family member 2 (LGI1-like protein 2) (Leucine-rich glioma-inactivated protein 2) LGI2 KIAA1916 LGIL2 Homo sapiens (Human) inhibitory synapse assembly [GO:1904862] extracellular region [GO:0005576] EIYVQAPR;SQVPIILQWNK 2 3.5 0.94699 -0.66054 0 0 0 0 12.4933 12.3676 15.0375 0 0 0 13.8731 0 Q8N0V5 GNT2A_HUMAN "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (N-acetylglucosaminyltransferase) (EC 2.4.1.150) (I-branching enzyme) (IGNT)" GCNT2 GCNT5 II NACGT1 Homo sapiens (Human) glycosaminoglycan biosynthetic process [GO:0006024]; maintenance of lens transparency [GO:0036438]; multicellular organism development [GO:0007275]; negative regulation of cell-substrate adhesion [GO:0010812]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; post-transcriptional regulation of gene expression [GO:0010608]; protein glycosylation [GO:0006486]; transforming growth factor beta receptor signaling pathway [GO:0007179] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]" LQADLNCLK 1 2.2 0.91468 -0.3348 0 0 0 0 0 0 0 0 0 0 0 10.9936 Q8N0W3 FCSK_HUMAN L-fucose kinase (Fucokinase) (EC 2.7.1.52) FCSK FUK Homo sapiens (Human) carbohydrate phosphorylation [GO:0046835]; GDP-L-fucose biosynthetic process [GO:0042350]; GDP-L-fucose salvage [GO:0042352]; response to dopamine [GO:1903350] cytosol [GO:0005829] ATP binding [GO:0005524]; fucokinase activity [GO:0050201] LARNLLQDVLRSWYAR 1 1.5 0.85008 -0.076074 0 0 0 6.03714 0 0 0 0 0 0 0 0 Q8N0W5 IQCK_HUMAN IQ domain-containing protein K IQCK Homo sapiens (Human) RAGEPFTEFFSIPFVEER;TPCPQDK 2 8.7 0.88109 -0.15252 0 0 0 0 5.69276 0 0 0 0 0 8.74591 0 Q8N0X2 SPG16_HUMAN Sperm-associated antigen 16 protein (Pf20 protein homolog) SPAG16 PF20 Homo sapiens (Human) axoneme assembly [GO:0035082]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; mucociliary clearance [GO:0120197]; sperm axoneme assembly [GO:0007288] axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126] MHHKRIVQEK;TLSIWDAR;VVGQISGLQETLK 3 4.9 0.97917 -1.9153 12.2581 0 0 0 10.3504 0 0 0 9.75231 0 0 0 Q8N0X7 SPART_HUMAN Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) SPART KIAA0610 SPG20 TAHCCP1 Homo sapiens (Human) adipose tissue development [GO:0060612]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; collateral sprouting in absence of injury [GO:0048669]; lipid catabolic process [GO:0016042]; lipid droplet organization [GO:0034389]; lipid transport [GO:0006869]; lipophagy [GO:0061724]; midbody abscission [GO:0061952]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; synapse [GO:0045202] lipid binding [GO:0008289]; ubiquitin protein ligase binding [GO:0031625] EASGTDVKQLDQGNKDVR;LQANWNR 2 3.8 0.95189 -0.71105 0 0 0 0 0 0 11.1302 0 0 0 0 0 Q8N0Y2 ZN444_HUMAN Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) ZNF444 EZF2 ZSCAN17 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EKPHACCECGK;EVAVPVK 2 5.5 0.964 -1.1801 0 0 0 9.57569 0 0 0 0 0 0 0 0 Q8N0Y3 OR4N4_HUMAN Olfactory receptor 4N4 (Olfactory receptor OR15-1) (Olfactory receptor OR15-5) OR4N4 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLSRHVVCQVDFIIRN;MLVDFLSEKK 2 8.2 0.97986 -1.8315 12.7952 0 0 0 0 0 0 0 0 0 0 0 Q8N0Z2 ABRA_HUMAN Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) ABRA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366] actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] actin binding [GO:0003779] ESGEGPAKSALR;VVGILMR 2 5 0.9113 -0.28591 0 0 0 0 0 0 0 0 12.6562 8.19175 0 0 Q8N0Z3 SPICE_HUMAN Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) SPICE1 CCDC52 SPICE Homo sapiens (Human) cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle [GO:0005819] LSQVPDPPDNMNLAKNFPAHIFEPAVLLTPPR 1 3.7 0.94406 -0.6481 0 7.39455 0 0 0 0 0 11.4478 5.05229 0 0 0 Q8N0Z6 TTC5_HUMAN Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap) TTC5 Homo sapiens (Human) cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; ribosome binding [GO:0043022] LAVQMDVHDGR 1 2.5 0.7931 0.016231 0 0 8.43917 0 0 0 0 9.05428 0 0 0 0 Q8N0Z9 VSI10_HUMAN V-set and immunoglobulin domain-containing protein 10 VSIG10 Homo sapiens (Human) cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] LGVEMLSESQLSDGK 1 2.8 0.61007 0.17558 0 0 0 0 0 0 0 0 0 7.63488 0 0 Q8N103 TAGAP_HUMAN T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) TAGAP TAGAP1 FKSG15 Homo sapiens (Human) regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] LPVHLLAVVFKDFLRSIPR;VTNQTLTKSEGDFPVPRVGSR 2 5.5 0.095532 0.37456 0 3.81854 0 0 0 0 10.344 10.4321 0 0 0 0 Q8N108 MIER1_HUMAN Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) MIER1 KIAA1610 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] DASRRTGDEK;TWLRTNWLR 2 3.9 0.97301 -2.863 0 0 12.0691 0 0 0 0 0 0 8.75992 8.65732 0 Q8N108 MIER1_HUMAN Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) MIER1 KIAA1610 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] DASRRTGDEK;MLVHDFDDER 2 4.1 0.30778 0.24924 0 0 0 0 0 0 0 0 0 0 5.50849 0 Q8N109 KI2LA_HUMAN Killer cell immunoglobulin-like receptor 2DL5A (CD antigen CD158f1) KIR2DL5A CD158F CD158F1 KIR2DL5 Homo sapiens (Human) immune response-regulating signaling pathway [GO:0002764] plasma membrane [GO:0005886] IFWKSILMGPVTPAHAGTYR 1 5.3 0.81783 -0.01737 0 0 0 0 0 0 0 0 9.5343 0 0 0 Q8N112 LSME2_HUMAN Leucine-rich single-pass membrane protein 2 LSMEM2 C3orf45 Homo sapiens (Human) membrane [GO:0016020] ILAHTLRTQEETLLKLR 1 10.4 0.86453 -0.084997 0 0 0 0 0 0 8.70183 0 0 0 0 0 Q8N114 SHSA5_HUMAN Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin) SHISA5 SCOTIN PSEC0133 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] WW domain binding [GO:0050699] ILLPLLLLLLLTPPPGAR 1 7.5 0.68587 0.16372 0 0 0 0 0 0 0 0 0 5.72555 0 0 Q8N118 CP4X1_HUMAN Cytochrome P450 4X1 (EC 1.14.14.-) (CYPIVX1) CYP4X1 UNQ1929/PRO4404 Homo sapiens (Human) lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] "anandamide 14,15 epoxidase activity [GO:0062189]; heme binding [GO:0020037]; iron ion binding [GO:0005506]" LYSLLYHSDIIFK;MMLDKWEK;NCIGQEFAMIELKVTIALILLHFR 3 8.8 0.9589 -1.0083 0 0 0 0 0 7.59186 8.96391 0 0 0 0 0 Q8N122 RPTOR_HUMAN Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) RPTOR KIAA1303 RAPTOR Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to L-leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931] 14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] IEGSKSLAQSWR;IVRIWDTDR;IWQNFDSARWCGVR;LDDQIFLNR;LDYFHNGNPRYTR;SLAQSWR 6 4.3 0.97455 -3.6568 15.9691 0 6.79429 0 9.41435 0 0 8.38085 11.6839 0 0 0 Q8N127 O5AS1_HUMAN Olfactory receptor 5AS1 (Olfactory receptor OR11-168) OR5AS1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] SSGGRSK 1 2.2 0.69354 0.16233 0 0 0 0 0 0 0 0 0 0 10.4828 0 Q8N128 F177A_HUMAN Protein FAM177A1 FAM177A1 C14orf24 Homo sapiens (Human) KDVLPTVDPTK;KEEEEEEEENR 2 10.3 0.91554 -0.34536 0 0 0 0 0 11.718 0 0 0 0 0 7.0278 Q8N129 CNPY4_HUMAN Protein canopy homolog 4 CNPY4 PSEC0237 UNQ1909/PRO4354 Homo sapiens (Human) positive regulation of protein localization to plasma membrane [GO:1903078] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] LLSTELQAELSRTGRSR;TEGEEEQEEEEEEEEEEGGDK 2 15.3 0.34083 0.23946 0 0 0 0 0 0 0 0 5.80232 0 0 7.6886 Q8N135 LGI4_HUMAN Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4) LGI4 LGIL3 UNQ6515/PRO21485 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; glial cell proliferation [GO:0014009]; myelination in peripheral nervous system [GO:0022011]; neuron maturation [GO:0042551]; regulation of myelination [GO:0031641] extracellular region [GO:0005576]; extracellular space [GO:0005615] GGAGILLLLLAGAGVVVAWRPPK;YIGDSMVMR 2 6 0.91656 -0.42263 0 0 5.37351 0 0 0 0 0 0 0 0 0 Q8N135 LGI4_HUMAN Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4) LGI4 LGIL3 UNQ6515/PRO21485 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; glial cell proliferation [GO:0014009]; myelination in peripheral nervous system [GO:0022011]; neuron maturation [GO:0042551]; regulation of myelination [GO:0031641] extracellular region [GO:0005576]; extracellular space [GO:0005615] GGAGILLLLLAGAGVVVAWRPPK;WGGRREIWGK 2 12.6 0.76691 0.059627 0 0 0 0 0 0 0 0 10.486 0 0 0 Q8N136 DAW1_HUMAN Dynein assembly factor with WD repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) DAW1 ODA16 WDR69 Homo sapiens (Human) cerebrospinal fluid circulation [GO:0090660]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary transport [GO:0042073]; outer dynein arm assembly [GO:0036158]; protein polyubiquitination [GO:0000209] ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IATGSFDKTCK;IFSAATR 2 4.3 0.98044 -1.6773 0 0 0 9.45094 9.58845 0 0 0 0 0 0 0 Q8N137 CNTRB_HUMAN Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) CNTROB LIP8 PP1221 Homo sapiens (Human) centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410]; regulation of cilium assembly [GO:1902017] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] protein domain specific binding [GO:0019904] LLLLDPPAPGLRSPRR;TLARVVEGWNRHEAER;VEMAEREERQQQVAEDYELR 3 9.4 0.95419 -0.90621 0 3.73335 0 0 0 0 6.62302 0 13.7386 0 0 0 Q8N139 ABCA6_HUMAN ATP-binding cassette sub-family A member 6 (EC 7.6.2.-) ABCA6 Homo sapiens (Human) lipid transport [GO:0006869] Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] LLPHSDEP;SSLLNILNGLSVPTEGSVTIYNK;SVYQQTKALLCKNFLK;VKETSQVTLVHTEILK 4 3.9 0.95164 -0.69917 0 0 4.94106 0 0 0 0 0 7.52857 6.73958 0 0 Q8N140 EID3_HUMAN EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Homo sapiens (Human) chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" EATSWMVKAETFHFVFGSFK;QLMYCVRQNR 2 9 0.94116 -0.61433 6.3482 0 0 0 0 0 0 0 0 0 0 10.4776 Q8N142 PURA1_HUMAN "Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (Adenylosuccinate synthetase-like 1) (AdSSL1) (IMP--aspartate ligase 1)" ADSS1 ADSSL1 Homo sapiens (Human) 'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; cellular response to xenobiotic stimulus [GO:0071466]; glutamine metabolic process [GO:0006541]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594] cytoplasm [GO:0005737]; cytosol [GO:0005829] actin filament binding [GO:0051015]; adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301] LDILDVLGEVKVGVSYK;VGIGAFPTEQINEIGGLLQTR 2 8.3 0.71401 0.1513 0 7.54905 0 8.82184 0 0 0 0 0 0 0 0 Q8N145 LGI3_HUMAN Leucine-rich repeat LGI family member 3 (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) LGI3 LGIL4 UNQ8190/PRO23199 Homo sapiens (Human) exocytosis [GO:0006887]; regulation of exocytosis [GO:0017157] extracellular region [GO:0005576]; extracellular space [GO:0005615]; juxtaparanode region of axon [GO:0044224]; synaptic vesicle [GO:0008021] AGRDSYLCLSR;ILRWEGTR;WDYVERQLRDYDR;WEGTRFSEVQALPSR 4 7.7 0.97599 -1.454 0 9.52916 0 0 0 7.13853 0 0 0 0 7.82286 0 Q8N149 LIRA2_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h) LILRA2 ILT1 LIR7 Homo sapiens (Human) defense response [GO:0006952]; immune response-regulating signaling pathway [GO:0002764]; innate immune response [GO:0045087]; innate immune response activating cell surface receptor signaling pathway [GO:0002220]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neutrophil activation involved in immune response [GO:0002283]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell activation [GO:0050867]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165] extracellular region [GO:0005576]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; IgM binding [GO:0001791]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor activity [GO:0038023] GQFHTFLLTKEGAGHPPLHLR 1 4.3 0.92128 -0.43896 0 0 0 0 0 0 0 0 0 8.39339 0 0 Q8N157 AHI1_HUMAN Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) AHI1 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; motile cilium assembly [GO:0044458]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; protein localization [GO:0008104]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; MKS complex [GO:0036038]; non-motile cilium [GO:0097730] identical protein binding [GO:0042802] EIKETEFK;NKLRNTQLATENPNGDASVEEDK 2 2.6 0.97512 -2.3586 0 0 0 0 0 0 0 0 0 0 9.76057 0 Q8N158 GPC2_HUMAN Glypican-2 [Cleaved into: Secreted glypican-2] GPC2 Homo sapiens (Human) cell migration [GO:0016477]; neuron differentiation [GO:0030182]; positive regulation of neuron projection development [GO:0010976]; regulation of protein localization to membrane [GO:1905475]; regulation of signal transduction [GO:0009966]; smoothened signaling pathway [GO:0007224] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] VTRSCAETR 1 1.6 0.96706 -1.3015 0 0 6.0824 0 0 0 10.0607 0 0 9.90058 0 0 Q8N163 CCAR2_HUMAN Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) CCAR2 DBC1 KIAA1967 Homo sapiens (Human) DNA damage response [GO:0006974]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA damage checkpoint [GO:2000003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of protein deacetylation [GO:0090311]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; DBIRD complex [GO:0044609]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; unfolded protein binding [GO:0051082] EEEAIKEEVVKEPK;FSATEVTNK;LLQELRRR;RRLTPLQLEIQR;TLAAEMQELR;VVTQNICQYR 6 6.6 0.97343 -2.903 0 0 10.4941 0 7.15107 0 2.11467 10.8379 0 0 10.2378 0 Q8N165 PDK1L_HUMAN Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like) PDIK1L CLIK1L Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVQIAFKDSSWET 1 3.8 0.92123 -0.4462 0 0 0 0 0 9.03886 0 0 0 0 0 0 Q8N184 ZN567_HUMAN Zinc finger protein 567 ZNF567 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ATLTVHQK;SYLIHHQRTHTGEKPYK 2 3.9 0.95535 -0.82599 0 0 0 0 0 7.05268 0 0 0 0 8.36803 0 Q8N187 CARTF_HUMAN Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24) CARF ALS2CR8 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; regulation of transcription by RNA polymerase II [GO:0006357] granular component [GO:0001652]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNMLKKNLVDAGGVLR;HNLSFFPTVNDIKNHIHEVQKSLR 2 5.7 0.95503 -0.78983 0 0 0 0 0 0 0 0 10.897 0 0 0 Q8N196 SIX5_HUMAN Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) SIX5 DMAHP Homo sapiens (Human) lens development in camera-type eye [GO:0002088]; Leydig cell proliferation [GO:0160024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QRDRTGAGGGAPCK;SPEDLER;TIWDGEETVYCFKER 3 4.9 0.91632 -0.36479 0 6.36718 0 0 0 0 9.81498 0 0 8.01078 0 0 Q8N1A0 KT222_HUMAN Keratin-like protein KRT222 (Keratin-222) (Keratin-222 pseudogene) KRT222 KA21 KRT222P Homo sapiens (Human) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] IQLEEDISK;LEQEIATYR 2 6.1 0.91492 -0.37984 0 0 0 0 0 0 0 0 11.3855 0 0 0 Q8N1B3 CCNQ_HUMAN Cyclin-Q (CDK10-activating cyclin) (Cyclin-M) (Cyclin-related protein FAM58A) CCNQ FAM58A Homo sapiens (Human) regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] EAPEGGGGGPAAR;GPEGQPAPEAR 2 9.7 0.96485 -1.1546 11.7243 0 0 0 0 0 0 0 8.84897 0 0 0 Q8N1B4 VPS52_HUMAN Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) VPS52 SACM2L Homo sapiens (Human) "ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] syntaxin binding [GO:0019905] AELINIHHLMVELK;GFFSKPSLRSR;SFTNFRNGTSIIQGALTQLIQLYHR 3 6.9 0.97502 -1.4355 0 0 0 0 10.2655 0 0 8.29848 0 0 10.1283 0 Q8N1C3 GBRG1_HUMAN Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1) GABRG1 Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851] AFLFSPFLLR;GPLKAFLFSPFLLR;KSDAHWITTPNR 3 5.6 0.53895 0.1853 0 0 11.1428 0 0 0 0 0 0 10.9363 0 0 Q8N1D5 CF107_HUMAN Cilia- and flagella-associated protein 107 CFAP107 C1orf158 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126] VEGLPYK 1 3.6 0.93745 -0.55994 0 0 0 0 9.97542 0 0 0 0 0 0 0 Q8N1E2 LYG1_HUMAN Lysozyme g-like protein 1 (EC 3.2.1.-) LYG1 UNQ1939/PRO4422 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253] extracellular region [GO:0005576] lysozyme activity [GO:0003796] RFPTWTPDQYLR 1 6.2 0.68212 0.1654 0 0 0 0 0 0 0 8.0036 0 7.56445 0 0 Q8N1F7 NUP93_HUMAN Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) NUP93 KIAA0095 Homo sapiens (Human) nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein import into nucleus [GO:0006606] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] ALRNNTDPYK;ASVLLGSRGLDISHISQR;KFESTDPR;LLMLYTRKFESTDPR;LVPLNQESVEER;LVQMEVLMN;LYDLAKNADK;NLQEIQQAGER;NMALSIAER;TSQETADVK;VASVAENK 11 13.6 0.95527 -0.98071 0 0 0 7.80607 10.2628 9.08284 10.8794 10.0595 0 13.0525 10.5862 0 Q8N1F8 S11IP_HUMAN Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) STK11IP KIAA1898 LIP1 LKB1IP STK11IP1 Homo sapiens (Human) protein localization [GO:0008104] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765] protein kinase binding [GO:0019901] ELSPLWLLAELR;GVPLHCLHGLR;IFPFKSLR 3 2.8 0.95402 -0.89051 0 0 0 9.12526 0 7.50486 0 0 8.5763 0 0 0 Q8N1G0 ZN687_HUMAN Zinc finger protein 687 ZNF687 KIAA1441 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] SLARHYDR;TATGPSTGGGTVISR 2 1.9 0.90766 -0.30683 0 7.38896 0 0 9.22137 0 0 10.4144 0 0 0 0 Q8N1G1 REXO1_HUMAN RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) REXO1 ELOABP1 KIAA1138 TCEB3BP1 Homo sapiens (Human) rRNA 3'-end processing [GO:0031125] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] QGQEVEPPR;QPPKEEK;SLDEGASQDAPK;YLNLFIEECLK 4 3.2 0.97777 -2.1667 12.311 11.1984 10.0794 9.86706 9.97039 9.85826 10.9964 12.4196 11.0109 0 0 0 Q8N1G2 CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) CMTR1 FTSJD2 KIAA0082 MTR1 Homo sapiens (Human) 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; mRNA processing [GO:0006397] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676] ADSLVEGTSSR;DIVEASSQKGR;FLIGLGK;SVFDVLDGEEMRRAR;VAPSSSDPK;VGIDDVRDYLFAVNIK 6 8.3 0.974 -3.0436 0 0 0 0 0 0 0 10.6 13.6813 11.4725 10.3024 0 Q8N1G4 LRC47_HUMAN Leucine-rich repeat-containing protein 47 LRRC47 KIAA1185 Homo sapiens (Human) phenylalanyl-tRNA aminoacylation [GO:0006432] phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] LLLRVLHVSENPVPLTVR;VVDLEGSLK 2 4.6 0.95499 -0.97497 0 4.70443 0 0 0 0 0 0 0 0 0 0 Q8N1H7 S6OS1_HUMAN Protein SIX6OS1 (Six6 opposite strand transcript 1) SIX6OS1 C14orf39 Homo sapiens (Human) homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of DNA-binding transcription factor activity [GO:0051090]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694] AVKAPESLEK;DEHVLTLNKTQSSQLFLPYESQK;INKCCEDIKENK;VLACTEQLK 4 9.2 0.97813 -2.1304 0 0 12.5025 0 0 0 9.95382 4.73194 0 0 0 0 Q8N1I0 DOCK4_HUMAN Dedicator of cytokinesis protein 4 DOCK4 KIAA0716 Homo sapiens (Human) cell chemotaxis [GO:0060326]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of postsynapse assembly [GO:0150052]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] EGVPDNIK;EYAMVDPEDISITELYR;GAHIRFEFRHCSTK;LEPEFFR;LPIPVDK;LTQNGDMLDLLKWR;LYDLHLK;QMTDRHYQQLLDSFNTKEELR;QVLVGHLTHDRMK 9 5.5 0.97344 -2.6489 0 0 8.82598 6.21985 6.98391 6.5364 0 0 0 0 9.66069 0 Q8N1I8 CAAS1_HUMAN Putative uncharacterized protein encoded by CACTIN-AS1 (Cactin antisense RNA 1) CACTIN-AS1 C19orf29-AS1 C19orf29OS Homo sapiens (Human) WVVKVVVRLVVLVPLEAR 1 8.5 0.57906 0.18098 0 0 0 0 0 0 0 5.27761 0 0 0 0 Q8N1L4 CP4Z2_HUMAN Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Homo sapiens (Human) membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ESYPVKEFEVYPELMEK;LELFQHVSLMTLDSIMK 2 10 0.89761 -0.24646 0 0 0 8.45738 0 0 0 10.2977 0 0 0 0 Q8N1L9 BATF2_HUMAN Basic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI) BATF2 Homo sapiens (Human) defense response to protozoan [GO:0042832]; integrated stress response signaling [GO:0140467]; myeloid dendritic cell differentiation [GO:0043011]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EIQSLQAELAWWSRTLHVHER 1 7.7 0.82548 -0.021489 0 0 0 0 0 0 11.1044 0 0 0 0 0 Q8N1M1 BEST3_HUMAN Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) BEST3 VMD2L3 Homo sapiens (Human) negative regulation of monoatomic ion transport [GO:0043271] chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] intracellularly calcium-gated chloride channel activity [GO:0005229]; ligand-gated monoatomic anion channel activity [GO:0099095]; metal ion binding [GO:0046872] FLSAHEHPSSPRRR;KLFNHLK;NLQVSLLAVDEMHMSLPKMKK;TVTYSSK 4 7.3 0.98022 -1.5568 0 0 0 8.74621 0 0 0 0 10.7518 12.321 0 0 Q8N1N2 DYNAP_HUMAN Dynactin-associated protein (Full) DYNAP C18orf26 Homo sapiens (Human) activation of protein kinase B activity [GO:0032148]; cellular response to ergosterol [GO:1901625]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] YSWREACDTGSSR 1 6.2 0.92387 -0.44831 10.8243 0 0 0 0 0 0 0 0 0 0 0 Q8N1N4 K2C78_HUMAN "Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)" KRT78 K5B KB40 Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] ARYEEIAR;FLEQQNK;FLEQQNKVLETK;LLCEYQELTSTK;TLNNQFASFIDK 5 8.5 0.95542 -0.86205 10.3358 0 0 6.03153 0 0 0 0 0 0 0 10.5606 Q8N1P7 CRBG2_HUMAN Beta/gamma crystallin domain-containing protein 2 (Absent in melanoma 1-like protein) CRYBG2 AIM1L Homo sapiens (Human) carbohydrate binding [GO:0030246] AGPSPSR;EEAGGPMARAKAR;EETVQGPIAPATSLPK;EVVKGPGAPDASFPTWK;VVLWAESR 5 3.7 0.97385 -2.4229 0 0 11.1383 0 0 0 0 0 9.17971 0 11.2208 0 Q8N1Q1 CAH13_HUMAN Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) CA13 Homo sapiens (Human) one-carbon metabolic process [GO:0006730] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myelin sheath [GO:0043209] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] ITDTLDSIKEK 1 4.2 0.92088 -0.44483 0 8.16897 0 0 0 0 0 0 0 0 0 0 Q8N1S5 S39AB_HUMAN Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) SLC39A11 C17orf26 ZIP11 Homo sapiens (Human) zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] copper ion transmembrane transporter activity [GO:0005375]; zinc ion transmembrane transporter activity [GO:0005385] SDPEGPALLFPESELSIR 1 5.3 0.84047 -0.046711 0 0 0 0 0 0 0 0 12.3092 0 0 0 Q8N1T3 MYO1H_HUMAN Unconventional myosin-Ih (Myosin-1H) MYO1H Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] KDGYTESLNQPFVNSR;NLVQKYCR;QLILTQKAAYVVELAKIK;VGQRILDPLLLLTWK;VVYQNEGER 5 6.4 0.93658 -0.55779 0 0 3.34412 7.17513 9.68778 0 0 9.09582 11.3126 0 8.49097 0 Q8N1V2 CFA52_HUMAN Cilia- and flagella-associated protein 52 (WD repeat-containing protein 16) (WD40-repeat protein up-regulated in HCC) CFAP52 WDR16 WDRPUH Homo sapiens (Human) establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; microtubule sliding [GO:0051012]; single fertilization [GO:0007338]; spermatid development [GO:0007286] 9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] SPGYKPIKK 1 1.5 0.93046 -0.47675 0 0 0 0 0 0 0 0 0 8.86217 0 0 Q8N1W1 ARG28_HUMAN Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) ARHGEF28 KIAA1998 RGNEF Homo sapiens (Human) cell morphogenesis [GO:0000902]; central nervous system neuron axonogenesis [GO:0021955]; ephrin receptor signaling pathway [GO:0048013]; neurofilament cytoskeleton organization [GO:0060052]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] ESLLSGVRSRSYSCSSPK;ESWLQERER;GELDLQLQEYQHSLERLR;IQQAVESCPEEKGGR;KFQNFIKLR;TMTRQDGETGDGAK 6 4.9 0.9744 -3.6241 11.3576 0 4.41772 0 0 7.32481 5.28481 0 0 9.02497 11.9353 0 Q8N1W2 ZN710_HUMAN Zinc finger protein 710 ZNF710 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] TRPPVRLVPKVK 1 1.8 0.86936 -0.097995 4.1521 0 0 0 0 0 0 0 0 0 0 0 Q8N201 INT1_HUMAN Integrator complex subunit 1 (Int1) INTS1 KIAA1440 UNQ1821/PRO3434 Homo sapiens (Human) embryo implantation [GO:0007566]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474] integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DYVHCLHK;GADASMACRK;LAEAAVAEK;LMSSAEECCR;LSSTPPLSALGR;RQPIDNVSRNLLR;TEMLNRELQTAQR;VLAMKGLSLVLSEGSLRDGEEK 8 4.4 0.97247 -2.6748 0 5.69889 0 0 8.72195 8.93366 7.61824 0 12.3284 9.05039 0 10.0511 Q8N228 SCML4_HUMAN Sex comb on midleg-like protein 4 SCML4 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] FLAKLCR;TAWIGCDR 2 4.9 0.98067 -1.6454 0 0 7.41244 0 0 0 0 0 0 0 0 0 Q8N239 KLH34_HUMAN Kelch-like protein 34 KLHL34 Homo sapiens (Human) extracellular space [GO:0005615] MSYFLSYCK 1 1.4 0.91275 -0.32218 0 0 0 5.49195 0 0 0 0 0 0 0 0 Q8N264 RHG24_HUMAN Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) ARHGAP24 FILGAP Homo sapiens (Human) "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of ruffle assembly [GO:1900028]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]" adherens junction [GO:0005912]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] GTPase activator activity [GO:0005096] SIRRVIWGPFGGGIFGQK 1 2.4 0.44904 0.19175 0 0 0 0 0 5.63422 0 0 0 0 0 0 Q8N271 PROM2_HUMAN Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2) PROM2 PROML2 UNQ2521/PRO6014 Homo sapiens (Human) negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of pinocytosis [GO:0048550]; positive regulation of cell projection organization [GO:0031346]; positive regulation of protein phosphorylation [GO:0001934]; regulation of GTPase activity [GO:0043087] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; prominosome [GO:0071914] cholesterol binding [GO:0015485] APGLLDSLYGTVRR;NLHQEKVVPQQSLVAK 2 3.6 0.36921 0.22658 13.0716 0 0 0 0 0 9.41301 0 0 0 0 0 Q8N283 ANR35_HUMAN Ankyrin repeat domain-containing protein 35 ANKRD35 Homo sapiens (Human) actin binding [GO:0003779] AAPGSIKQDEEK;EDEDPCSEEWR;EELAAVWR;EELAAVWREK;GQLEKEMSVLR;LSNSNLLEELGELGRER;NDKSALILACEK;VPGAQGEPLGALGGEK 8 8.9 0.97514 -3.1464 0 0 12.3458 5.7717 8.96423 0 0 0 3.94392 11.8456 9.24648 0 Q8N2C3 DEPD4_HUMAN DEP domain-containing protein 4 DEPDC4 Homo sapiens (Human) intracellular signal transduction [GO:0035556] SSYDCCK 1 2.4 0.91108 -0.32682 0 0 0 4.9995 0 0 0 0 0 0 0 0 Q8N2C7 UNC80_HUMAN Protein unc-80 homolog UNC80 C2orf21 KIAA1843 Homo sapiens (Human) monoatomic cation homeostasis [GO:0055080] axon [GO:0030424]; cation channel complex [GO:0034703]; plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] DESTPVSNHRLALTMLIK;EEFRRPR;ISFAGVLDENEDSK;LDKMQFR;RWNLIHYNK;SLGCAYGCGEGHRGLSGDR;TQDLTMKCNEEEK;TRIPIFVLLRPFIQCK 8 3.2 0.97546 -3.5761 8.37313 10.2522 0 0 8.65507 0 7.69056 0 12.0678 0 0 3.21675 Q8N2E2 VWDE_HUMAN von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) cell surface [GO:0009986]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] CVGPSTCSCPSGWSGK;ITVIYDGACQVCGLYKNDSCTIK;KHINLTK;SLTIRAPSVDYR;SRECVAPNICK 5 6.6 0.9804 -1.72 0 9.08305 0 0 9.54454 0 8.74675 0 7.55067 0 4.10501 9.99845 Q8N2F6 ARM10_HUMAN Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) ARMC10 SVH PSEC0198 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of growth rate [GO:0040010] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] DNA binding domain binding [GO:0050692]; p53 binding [GO:0002039] ALITLGNNAAFSVNQAIIR 1 5.5 0.78316 0.024033 0 0 0 0 0 0 0 0 8.78535 0 0 0 Q8N2G6 ZCH24_HUMAN Zinc finger CCHC domain-containing protein 24 ZCCHC24 C10orf56 Homo sapiens (Human) RNA binding [GO:0003723]; zinc ion binding [GO:0008270] VLGYYCRR;WMSGNSWANMGQECIK 2 10 0.91334 -0.38765 12.5679 0 5.25452 8.40374 8.37521 0 0 0 0 0 7.03309 7.19042 Q8N2G8 GHDC_HUMAN GH3 domain-containing protein GHDC D11LGP1E LGP1 Homo sapiens (Human) cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580] acid-amino acid ligase activity [GO:0016881] HRHLAQCLQER;NLSEENRDK 2 3.8 0.98096 -1.7574 0 0 0 0 0 0 0 0 0 11.4338 0 0 Q8N2I2 ZN619_HUMAN Zinc finger protein 619 ZNF619 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFRWNASFIQHQKWHTR 1 3 0.96349 -1.0985 0 0 0 0 0 0 0 0 0 0 0 10.6809 Q8N2I9 STK40_HUMAN Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) STK40 SGK495 SHIK Homo sapiens (Human) glycogen metabolic process [GO:0005977]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016] cytosol [GO:0005829]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALGSGISGNNAKR 1 3 0.91048 -0.28459 0 0 0 0 10.4097 0 0 0 0 0 0 0 Q8N2K0 ABD12_HUMAN Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-) ABHD12 C20orf22 Homo sapiens (Human) acylglycerol catabolic process [GO:0046464]; adult walking behavior [GO:0007628]; arachidonate metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395]; regulation of inflammatory response [GO:0050727]; response to auditory stimulus [GO:0010996] AMPA glutamate receptor complex [GO:0032281]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] lysophospholipase activity [GO:0004622]; monoacylglycerol lipase activity [GO:0047372]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620] GVWLRLR;GVWLRLRK 2 2 0.91593 -0.37305 0 0 0 7.45845 7.49578 0 0 0 0 0 0 0 Q8N2M8 CLASR_HUMAN "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)" CLASRP SFRS16 SWAP2 UNQ2428/PRO4988 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654] ALEEEKAMYSGR;YSRSRSR 2 2.8 0.9751 -1.4348 0 0 0 0 0 0 0 0 0 0 11.3092 0 Q8N2N9 AN36B_HUMAN Ankyrin repeat domain-containing protein 36B (CLL-associated antigen KW-1) ANKRD36B Homo sapiens (Human) identical protein binding [GO:0042802] CELNLCDREDR;DIEKMYKSGYNTMEK;EEIKSQLKHEILELEK;ILQHSSLMLQVFES;QRAEKATSDDK 5 5 0.97314 -1.3768 0 0 0 0 0 0 0 0 10.5611 0 0 0 Q8N2Q7 NLGN1_HUMAN Neuroligin-1 NLGN1 KIAA1070 Homo sapiens (Human) "AMPA glutamate receptor clustering [GO:0097113]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; cytoskeletal matrix organization at active zone [GO:0048789]; establishment of protein localization [GO:0045184]; excitatory synapse assembly [GO:1904861]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; neurexin clustering involved in presynaptic membrane assembly [GO:0097115]; neuron cell-cell adhesion [GO:0007158]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein targeting [GO:0006605]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of neuron differentiation [GO:0045664]; regulation of NMDA receptor activity [GO:2000310]; rhythmic process [GO:0048511]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553]" "asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; filopodium tip [GO:0032433]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; protein complex involved in cell-cell adhesion [GO:0098635]; receptor complex [GO:0043235]; synapse [GO:0045202]; synaptic cleft [GO:0043083]" amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023] KGGPLTK 1 0.8 0.89676 -0.25139 0 0 0 0 0 0 0 0 0 9.36672 0 0 Q8N2R0 OSR2_HUMAN Protein odd-skipped-related 2 OSR2 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; head development [GO:0060322]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; osteoblast proliferation [GO:0033687]; pattern specification process [GO:0007389]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephros development [GO:0048793]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]; urogenital system development [GO:0001655] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GEVSPSQGPLAQEDEAR 1 3.9 0.65992 0.16926 0 0 0 0 0 0 0 0 0 0 0 8.18943 Q8N2R8 FA43A_HUMAN Protein FAM43A FAM43A PP7298 Homo sapiens (Human) LTVSAQGIRMVHAEER 1 3.8 0.91669 -0.42258 0 0 0 0 0 0 0 0 0 0 6.30274 0 Q8N2S1 LTBP4_HUMAN Latent-transforming growth factor beta-binding protein 4 (LTBP-4) LTBP4 Homo sapiens (Human) elastic fiber assembly [GO:0048251]; hormone secretion [GO:0046879]; protein folding [GO:0006457]; regulation of cell growth [GO:0001558]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; integrin binding [GO:0005178]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024] AEAAARAEAAAPYTVLAQSAPR;EDGYSDASGFGYCFR;EICPAGPGYHYSASDLR;GACKNLPGSFR;KCAGPQRCLNPVPAVPSPSPSVR;LSPQGTR;VSLSQPR 7 6.3 0.9591 -1.0405 0 0 9.50279 9.62454 7.48236 3.41981 0 0 0 0 11.6718 0 Q8N2U9 S66A2_HUMAN Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) SLC66A2 PQLC1 Homo sapiens (Human) "phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] SFTAADSKDEEVK 1 4.8 0.97372 -1.4055 0 0 0 0 8.41578 0 0 0 0 11.7833 0 0 Q8N2X6 EXAS1_HUMAN Uncharacterized protein EXOC3-AS1 (EXOC3 antisense RNA 1) (EXOC3 antisense gene protein 1) EXOC3-AS1 C5orf55 Homo sapiens (Human) extracellular region [GO:0005576] MPAVFMLASSSALQCGRGVPRFPR;VGNQTSVIPATSR 2 31.1 0.8456 -0.058669 0 0 0 0 0 0 10.9184 0 0 6.42967 0 0 Q8N2Y8 RUSC2_HUMAN AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) RUSC2 KIAA0375 Homo sapiens (Human) cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] small GTPase binding [GO:0031267] AGGDWLR;AVNIAVDLIVAHFGTSRDPGVK;EARPTNR;RVTSFAELAK;SLQRSPPVR 5 3.6 0.97306 -2.5296 12.2492 0 8.2643 11.263 0 7.02702 7.08119 0 0 11.9487 0 0 Q8N2Z9 CENPS_HUMAN Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa) CENPS APITD1 FAAP16 MHF1 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] SEDGSKNSR;TTINTEDVKLLAR 2 15.9 0.9811 -1.6967 0 12.2061 0 0 0 0 0 0 0 0 0 0 Q8N302 AGGF1_HUMAN Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) AGGF1 GPATC7 GPATCH7 VG5Q Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676] IGIHHKNSPPK;KDPDSSATNEEK;MGWKKGEGLGK 3 4.8 0.78396 0.02465 0 0 0 0 10.6817 0 0 11.5008 0 0 9.72794 0 Q8N302 AGGF1_HUMAN Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) AGGF1 GPATC7 GPATCH7 VG5Q Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676] LLHHTERLYQNAESNNQELRTQVR 1 22 0.62148 0.1736 0 0 0 0 0 0 0 0 0 0 8.18582 0 Q8N307 MUC20_HUMAN Mucin-20 (MUC-20) MUC20 KIAA1359 UNQ2782/PRO7170 Homo sapiens (Human) hepatocyte growth factor receptor signaling pathway [GO:0048012] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] ELHAHAPHFQVSLLR;LSVASPEDLTDPR 2 3.9 0.90929 -0.3172 0 0 0 8.78352 0 0 0 0 0 0 6.07446 0 Q8N309 LRC43_HUMAN Leucine-rich repeat-containing protein 43 LRRC43 Homo sapiens (Human) axoneme assembly [GO:0035082] axoneme [GO:0005930] dynein complex binding [GO:0070840] LTLARDSKK 1 1.4 0.9762 -1.4775 0 0 0 0 11.7346 0 0 0 0 0 0 0 Q8N319 CF223_HUMAN Uncharacterized protein LINC03040 LINC03040 C6orf223 Homo sapiens (Human) TPPPPQT 1 6.7 0.64731 0.17077 0 0 0 0 0 0 0 0 0 0 0 9.14356 Q8N323 NXPE1_HUMAN NXPE family member 1 (Protein FAM55A) NXPE1 FAM55A Homo sapiens (Human) extracellular region [GO:0005576] TLKFFDLHETGIFK;VGVEMMK;VIIKTENIREMHIETER 3 6.9 0.95435 -0.90944 11.0305 0 0 0 0 0 0 0 0 0 0 7.63249 Q8N326 CJ111_HUMAN Putative uncharacterized protein RPP38-DT (RPP38 divergent transcript protein) RPP38-DT C10orf111 Homo sapiens (Human) membrane [GO:0016020] ESLQTPQHR;ESLQTPQHRENQDK;LRNLDLLIYPWPELR 3 18.7 0.97517 -1.4345 0 0 0 5.52168 0 7.64299 0 9.77151 0 9.41785 0 0 Q8N335 GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8) GPD1L KIAA0089 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; NAD metabolic process [GO:0019674]; NADH metabolic process [GO:0006734]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate [GO:0002027]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; ventricular cardiac muscle cell action potential [GO:0086005] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] glycerol-3-phosphate dehydrogenase (NAD+) activity [GO:0141152]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] ELLQTPNFR;EMLNGQKLQGPQTSAEVYR;KLTDIINNDHENVK;TIEELEK;VAEAFAR;VPKKALGITLIK 6 19.4 0.97416 -1.4207 0 0 0 7.08661 0 0 4.43476 0 0 6.97154 5.95089 8.81506 Q8N336 ELMD1_HUMAN ELMO domain-containing protein 1 ELMOD1 Homo sapiens (Human) cilium assembly [GO:0060271]; protein transport [GO:0015031] cilium [GO:0005929]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794] GTPase activator activity [GO:0005096] REAYDSDNPQHEEMLLKLWK 1 6.1 0.85178 -0.079704 0 0 0 0 8.39519 0 0 0 0 0 0 0 Q8N339 MT1M_HUMAN Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) MT1M MT1K Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] CAHGCVCK;KSCCSCCPVGCAK;MDPNCSCTTGVSCACTGSCTCK;MDPNCSCTTGVSCACTGSCTCKECK 4 75.4 0.95398 -0.92232 0 9.00663 7.64003 8.2436 8.40096 6.07264 0 0 0 0 0 0 Q8N350 CBARP_HUMAN Voltage-dependent calcium channel beta subunit-associated regulatory protein CBARP C19orf26 Homo sapiens (Human) negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of voltage-gated calcium channel activity [GO:1901386] growth cone [GO:0030426]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672] transmembrane transporter binding [GO:0044325] ATLAIFQPPGKALTGR 1 2.3 0.91561 -0.43157 7.13812 0 0 0 4.82934 0 0 0 5.00518 9.85026 0 0 Q8N371 KDM8_HUMAN Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) KDM8 JMJD5 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; fibroblast proliferation [GO:0048144]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; regulation of signal transduction by p53 class mediator [GO:1901796] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; peptidyl-arginine 3-dioxygenase activity [GO:0106157] GVADHWPCMQK;LEKTVPR;RDECLQSSEVILDYSWEK 3 8.7 0.95802 -1.0158 0 0 0 0 3.59753 6.66235 0 0 0 0 0 0 Q8N386 LRC25_HUMAN Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein) LRRC25 MAPA UNQ6169/PRO20174 Homo sapiens (Human) cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] ELPVTFFAHLQK 1 3.9 0.26709 0.26738 0 10.7787 10.544 0 0 0 0 0 0 0 0 0 Q8N387 MUC15_HUMAN Mucin-15 (MUC-15) MUC15 UNQ750/PRO1481 Homo sapiens (Human) extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] LALAKILLISTLFYSLLSGSHGK;TDSFSHRR;TTLQPTLK 3 11.7 0.97926 -1.8814 0 0 0 0 4.92941 0 0 0 0 0 0 0 Q8N392 RHG18_HUMAN Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) ARHGAP18 Homo sapiens (Human) regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ruffle [GO:0001726] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096] LLWTIPK;STNDADVPQGVIRVQAPHLSKVSMAIQLTEELK;VQAPHLSK 3 6 0.97821 -1.9794 0 3.36583 0 0 0 0 11.4707 8.68285 0 0 8.29209 0 Q8N393 ZN786_HUMAN Zinc finger protein 786 ZNF786 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AETQMPWSSPR;AETQMPWSSPRVQR;EHLRVHSGERPFQCLK;ELYKHVMR 4 4.9 0.96518 -1.1213 9.17045 0 0 0 8.78293 0 0 0 0 0 0 0 Q8N398 VW5B2_HUMAN von Willebrand factor A domain-containing protein 5B2 VWA5B2 Homo sapiens (Human) EAAWDQALHR 1 0.8 0.84509 -0.056129 0 0 0 0 0 0 0 0 10.3741 0 0 0 Q8N3A8 PARP8_HUMAN Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8) PARP8 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; protein auto-ADP-ribosylation [GO:0070213] endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539] LQKENGEESR;NYDRVMK;SYSSAPK;TEPIIVR 4 3.6 0.97529 -3.3697 0 0 6.5831 0 0 0 8.09429 0 0 0 0 8.8704 Q8N3C0 ASCC3_HUMAN "Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)" ASCC3 HELIC1 RQT2 Homo sapiens (Human) DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ADLIVTTPEKWDGVSR;ITIVDRFLNSSNDHR 2 1.4 0.96012 -1.0526 0 0 0 0 0 0 0 0 0 8.33909 0 12.2776 Q8N3C7 CLIP4_HUMAN CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) CLIP4 RSNL2 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122] cell cortex [GO:0005938]; intracellular membrane-bounded organelle [GO:0043231]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] microtubule plus-end binding [GO:0051010] IDVAHVTSK;LGDRVVIAGQKVGTLR;YGIFAPLSK 3 4.8 0.91282 -0.32247 0 0 0 10.2511 0 0 0 0 0 0 0 0 Q8N3D4 EH1L1_HUMAN EH domain-binding protein 1-like protein 1 EHBP1L1 Homo sapiens (Human) endosome [GO:0005768]; membrane [GO:0016020] DELVRDLDHKER;QIDGRAAEVEMQLRSLMESGANK;RQDQLQLLMEEQDLER;RQDQLQLLMEEQDLERR 4 3.4 0.981 -1.6903 0 10.4453 0 0 10.6525 0 0 0 0 9.28526 0 0 Q8N3E9 PLCD3_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)" PLCD3 KIAA1964 Homo sapiens (Human) angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; regulation of cell population proliferation [GO:0042127] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435] ECDHSNNDR;LQEDGLSVWFQRR;SRTWHKER;TWHKERLYR 4 4.2 0.96367 -1.1875 0 12.621 0 0 0 0 0 0 10.906 10.8203 10.9772 0 Q8N3F8 MILK1_HUMAN MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) MICALL1 KIAA1668 MIRAB13 Homo sapiens (Human) endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; neuron projection development [GO:0031175]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; slow endocytic recycling [GO:0032458] cytoplasmic side of endosome membrane [GO:0010009]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; recycling endosome membrane [GO:0055038] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267] ESELIYVFK;QQNLEQR;QQNLEQRQADVEYELR;TKKRPAPR;VLMQELVTLIEQR 5 5.3 0.93319 -0.51249 0 8.18562 8.96544 0 0 9.89382 0 0 5.63975 0 6.50543 0 Q8N3G9 TM130_HUMAN Transmembrane protein 130 TMEM130 UNQ719/PRO1383 Homo sapiens (Human) Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] MAQAVWSRLGR 1 2.5 0.74613 0.10053 0 0 0 0 0 0 11.0037 0 0 0 0 0 Q8N3H0 TAFA2_HUMAN Chemokine-like protein TAFA-2 TAFA2 FAM19A2 Homo sapiens (Human) memory [GO:0007613]; visual learning [GO:0008542] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] receptor ligand activity [GO:0048018] LLIIIFIVTLWGK 1 9.9 0.71026 0.15876 3.83167 0 0 0 0 0 0 0 0 0 0 0 Q8N3J2 METL4_HUMAN N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-) METTL4 Homo sapiens (Human) "methylation [GO:0032259]; mRNA modification [GO:0016556]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of mitochondrial DNA replication [GO:0090296]; regulation of mitochondrial transcription [GO:1903108]; regulation of RNA splicing [GO:0043484]; snRNA (adenine-N6)-methylation [GO:0120049]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] nucleic acid binding [GO:0003676]; RNA methyltransferase activity [GO:0008173]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity [GO:0106347] FIKEELYPSWSVEVVAEWHWVK 1 4.7 0.82978 -0.025381 0 0 0 0 0 0 0 0 0 0 9.69876 0 Q8N3J3 HROB_HUMAN Homologous recombination OB-fold protein HROB C17orf53 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA synthesis involved in DNA repair [GO:0000731]; female gamete generation [GO:0007292]; interstrand cross-link repair [GO:0036297]; male gamete generation [GO:0048232]; recombinational repair [GO:0000725] nucleus [GO:0005634]; site of DNA damage [GO:0090734] single-stranded DNA binding [GO:0003697] IPLQPQAPVSSIGSPVGTPK;TPQQPTHPSTRAKTR 2 5.4 0.11475 0.36217 0 0 0 9.27977 0 0 0 0 0 6.505 0 0 Q8N3J5 PPM1K_HUMAN "Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)" PPM1K PP2CM Homo sapiens (Human) branched-chain amino acid catabolic process [GO:0009083]; regulation of intracellular signal transduction [GO:1902531]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity [GO:0047385]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] LTIDHTPER;LTIDHTPERK;LTIDHTPERKDEK 3 3.5 0.97719 -2.2288 0 0 0 9.54133 0 0 0 0 0 0 0 11.9586 Q8N3J9 ZN664_HUMAN Zinc finger protein 664 (Zinc finger protein 176) (Zinc finger protein from organ of Corti) ZNF664 ZFOC1 ZNF176 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CYECGKAFSQSSSLCIHQR 1 7.3 0.88334 -0.17484 0 0 0 0 0 0 0 6.43065 0 0 0 0 Q8N3K9 CMYA5_HUMAN Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) CMYA5 C5orf10 DTNBP2 SPRYD2 TRIM76 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; M band [GO:0031430]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529] ANTELSWPSKEDSQEK;ENQVYVLSEGK;FISEVSREDYGK;LSDQDEEGKIK;LVMEEAK;MFNSVKEELIPLQFYGTLPK;SNYAQFISNTSASNADK;VLAQYDEK;YAAPLNATQESQKKIINEASQFKPK;YILKDDILHDTSLTQK 10 3.5 0.97625 -5.0091 0 6.32128 10.6853 9.57459 0 9.79245 0 0 10.8774 9.43265 0 0 Q8N3P4 VPS8_HUMAN Vacuolar protein sorting-associated protein 8 homolog VPS8 KIAA0804 Homo sapiens (Human) endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542] CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770] metal ion binding [GO:0046872] ILQDPVYGK;KLPDSFSLHGSVMR;LSENSVAK;WTCYKCSSSNK 4 2.9 0.92973 -0.46979 0 0 0 0 0 0 11.3488 0 6.5037 0 10.1542 0 Q8N3R3 TCAIM_HUMAN "T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1)" TCAIM C3orf23 TOAG1 Homo sapiens (Human) mitochondrion [GO:0005739] AKGCTIIFTDR;SLRGLQMILNSDR 2 4.8 0.98022 -2.0416 0 0 7.10559 0 8.54612 0 0 0 0 0 0 0 Q8N3R9 PALS1_HUMAN "Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)" PALS1 MPP5 Homo sapiens (Human) central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; morphogenesis of an epithelial sheet [GO:0002011]; myelin assembly [GO:0032288]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization to myelin sheath abaxonal region [GO:0035750]; protein localization to plasma membrane [GO:0072659]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lateral loop [GO:0043219]; myelin sheath adaxonal region [GO:0035749]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schmidt-Lanterman incisure [GO:0043220] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] AVDCPGDLGTR;NLYGTSIDSVRQVINSGK 2 4.5 0.96513 -1.1557 0 0 0 0 0 0 9.89848 0 0 0 9.85303 0 Q8N3S3 PHTF2_HUMAN Protein PHTF2 PHTF2 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] MWLSLRSYLKR 1 1.4 0.86551 -0.089257 0 0 8.98505 0 0 0 0 0 0 0 0 0 Q8N3T1 GLT15_HUMAN Polypeptide N-acetylgalactosaminyltransferase 15 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 2) (GalNAc-T-like protein 2) (pp-GaNTase-like protein 2) (Polypeptide N-acetylgalactosaminyltransferase-like protein 2) (Protein-UDP acetylgalactosaminyltransferase-like protein 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2) GALNT15 GALNTL2 UNQ770/PRO1564 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] ALQSPISPIR;DLYLRPCDGKARQQWR 2 4.1 0.94496 -0.64153 0 0 0 0 0 0 0 0 0 0 10.3332 0 Q8N3T6 T132C_HUMAN Transmembrane protein 132C TMEM132C Homo sapiens (Human) membrane [GO:0016020] DFSLAATSQDEAVVSVPQPR;ESEDEDEEER;QEAVFSTWLQFSDGSVTPLDIYDTK 3 5 0.77642 0.042581 8.54493 8.27305 7.6094 5.7352 0 0 0 0 0 0 8.54106 0 Q8N3U1 YS014_HUMAN Putative uncharacterized protein LOC400692 Homo sapiens (Human) AGTRTKASPVWGR 1 10.6 0.76751 0.059393 0 0 0 0 0 0 0 0 0 6.67398 0 0 Q8N3U4 STAG2_HUMAN Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) STAG2 SA2 Homo sapiens (Human) cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682] CLTALQGLYYNK;ETMSKTRQIDK 2 1.9 0.88761 -0.18616 0 0 0 11.1429 0 0 0 0 11.5962 0 0 0 Q8N3V7 SYNPO_HUMAN Synaptopodin SYNPO KIAA1029 Homo sapiens (Human) modification of dendritic spine [GO:0098886]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of stress fiber assembly [GO:0051492]; spine apparatus assembly [GO:1905355] actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spine apparatus [GO:0097444]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779] YPTNAPGAFR 1 1.1 0.91743 -0.35329 0 0 10.4676 0 0 0 0 0 10.4561 0 0 0 Q8N3X1 FNBP4_HUMAN Formin-binding protein 4 (Formin-binding protein 30) FNBP4 FBP30 KIAA1014 Homo sapiens (Human) nucleoplasm [GO:0005654] EVNEGIQALSNSEEEK;IDENSDK;MFVRATSPESTSR;QYEINATPKGWSCHWDRDHR 4 5.5 0.95599 -0.84549 0 0 12.3282 0 8.60106 0 0 0 0 9.9969 9.57945 0 Q8N3X6 LCORL_HUMAN Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein) LCORL Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226] QFAIEYISKSGKTQENR 1 2.8 0.85596 -0.080618 0 10.6279 0 0 0 0 0 0 0 0 0 0 Q8N3X6 LCORL_HUMAN Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein) LCORL Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226] VTQFKEK 1 3.3 0.96408 -1.2021 0 0 0 0 0 9.62892 0 0 0 0 0 10.395 Q8N3Y1 FBXW8_HUMAN F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) FBXW8 FBW6 FBW8 FBX29 FBXO29 FBXW6 Homo sapiens (Human) cell population proliferation [GO:0008283]; cilium assembly [GO:0060271]; Golgi organization [GO:0007030]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] centriole [GO:0005814]; ciliary basal body [GO:0036064]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LIFQECRAK;LLEGAGRPPAARATRAEGQDVASR;MDDYSLDEFRR 3 7.4 0.89763 -0.24663 0 3.95624 0 0 8.19672 0 10.1337 0 7.08768 0 0 4.96634 Q8N3Y3 LARG2_HUMAN "Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)]" LARGE2 GYLTL1B PP5656 Homo sapiens (Human) muscle cell cellular homeostasis [GO:0046716]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] glucuronosyltransferase activity [GO:0015020]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285] EPGGRAGAPGCFPGPLMPRVPPDGR 1 3.5 0.84109 -0.045469 12.137 0 0 0 0 0 0 0 0 7.38033 0 0 Q8N3Z3 GTPB8_HUMAN GTP-binding protein 8 GTPBP8 Homo sapiens (Human) mitochondrion [GO:0005739] GTP binding [GO:0005525]; metal ion binding [GO:0046872] FLAPYGRQDLHLR 1 4.6 0.92359 -0.44783 0 0 0 0 0 0 0 10.4365 0 0 0 0 Q8N414 PGBD5_HUMAN PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5) PGBD5 Homo sapiens (Human) non-replicative DNA transposition [GO:0098038] nucleoplasm [GO:0005654]; nucleus [GO:0005634] endonuclease activity [GO:0004519]; transposase activity [GO:0004803] SLALVMSQARFEK 1 2.5 0.92224 -0.44703 0 0 0 0 0 0 0 0 0 10.483 0 0 Q8N423 LIRB2_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d) LILRB2 ILT4 LIR2 MIR10 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; learning or memory [GO:0007611]; negative regulation of antigen processing and presentation [GO:0002578]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of postsynaptic density organization [GO:1905875]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; regulation of dendritic cell differentiation [GO:2001198]; regulation of long-term synaptic potentiation [GO:1900271]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; protein-containing complex binding [GO:0044877] RQGKHWTSSPAQLPTPR 1 3.3 0.44403 0.19326 0 6.94205 0 0 0 0 0 0 0 0 0 0 Q8N427 TXND3_HUMAN Thioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2) NME8 SPTRX2 TXNDC3 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer dynein arm [GO:0036157]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] 3'-5' exonuclease activity [GO:0008408]; microtubule binding [GO:0008017] IIEKIQGANAPLVNKK;IIKDEDFKILEQR 2 4.9 0.74438 0.099395 0 0 0 0 0 0 0 3.47768 0 0 6.69919 0 Q8N428 GLT16_HUMAN Polypeptide N-acetylgalactosaminyltransferase 16 (EC 2.4.1.41) (Polypeptide GalNAc transferase 16) (GalNAc-T16) (Polypeptide GalNAc transferase-like protein 1) (GalNAc-T-like protein 1) (pp-GaNTase-like protein 1) (Polypeptide N-acetylgalactosaminyltransferase-like protein 1) (Protein-UDP acetylgalactosaminyltransferase-like protein 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1) GALNT16 GALNTL1 KIAA1130 Homo sapiens (Human) protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] QLKAGEDPYR 1 1.8 0.96474 -1.2223 0 0 0 9.0219 0 0 9.97943 0 0 0 0 0 Q8N431 RGF1C_HUMAN Ras-GEF domain-containing family member 1C RASGEF1C Homo sapiens (Human) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DVVGRIAPCDEAYR;VCHLCIEQQQLDKPVLDKARVR;WFNRLCYLVATEICMPAK 3 11.6 0.95479 -0.90219 0 0 0 0 0 0 10.871 0 0 9.04314 7.27743 11.7929 Q8N441 FGRL1_HUMAN Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) FGFRL1 FGFR5 FHFR UNQ480/PRO943 Homo sapiens (Human) cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diaphragm development [GO:0060539]; heart valve morphogenesis [GO:0003179]; negative regulation of cell population proliferation [GO:0008285]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412] cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] DGRTIHSGWSRFR;TIHSGWSR;VDVIQRTR;VLPQGLKVK 4 6 0.98069 -1.6184 0 4.74814 3.612 0 0 0 0 0 9.64703 0 0 0 Q8N443 RIBC1_HUMAN RIB43A-like with coiled-coils protein 1 RIBC1 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; sperm flagellum [GO:0036126] GLGSFNQQLANEQKAQ;KQAHRQAEK 2 10.5 0.92418 -0.45008 0 9.85818 0 0 0 9.1164 0 0 0 0 0 0 Q8N446 ZN843_HUMAN Zinc finger protein 843 ZNF843 Homo sapiens (Human) metal ion binding [GO:0046872] VCPFCCCSCGDSVNEK 1 4.6 0.64794 0.17129 0 0 0 0 0 0 4.72738 0 0 0 0 0 Q8N448 LNX2_HUMAN Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1) LNX2 PDZRN1 Homo sapiens (Human) neural precursor cell proliferation [GO:0061351]; neuron differentiation [GO:0030182] plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842] CPGASHR;DLTQCVTCQEK 2 2.6 0.94023 -0.58042 0 0 0 0 0 0 7.29591 0 0 0 10.3225 0 Q8N461 FXL16_HUMAN F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) FBXL16 C16orf22 FBL16 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] SLDLSWCPR 1 1.9 0.9205 -0.44638 0 0 0 0 10.691 0 0 0 0 0 0 0 Q8N468 MFD4A_HUMAN Major facilitator superfamily domain-containing protein 4A (Major facilitator superfamily domain-containing protein 4) MFSD4A MFSD4 UNQ3064/PRO9894 Homo sapiens (Human) membrane [GO:0016020] D-glucose transmembrane transporter activity [GO:0055056] MYQKDSAVFLQLPVPMAVLMLLSKER 1 6.1 0.6831 0.16504 0 0 0 0 7.77827 0 0 0 0 0 0 0 Q8N475 FSTL5_HUMAN Follistatin-related protein 5 (Follistatin-like protein 5) FSTL5 KIAA1263 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of BMP signaling pathway [GO:0030510] extracellular region [GO:0005576] calcium ion binding [GO:0005509] NGIDITPK;SYQPLMRLRHK 2 2.2 0.89077 -0.21006 0 0 7.2074 0 0 0 0 0 0 6.33559 0 0 Q8N490 PNKD_HUMAN Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2) PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778 Homo sapiens (Human) "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]" membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; presynaptic cytosol [GO:0099523] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] ASHNRTR;AVQASIEKEGVTLVAILCTHK;DLSRRHR 3 9.1 0.97281 -2.5972 0 0 0 0 0 0 4.89015 0 0 0 0 0 Q8N4A0 GALT4_HUMAN Polypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4) GALNT4 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] LLRERLR;SGQTVPGAAR 2 4.2 0.89624 -0.24992 0 0 9.26934 0 9.26275 5.38967 0 0 0 0 0 0 Q8N4B4 FBX39_HUMAN F-box only protein 39 FBXO39 FBX39 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] LARILLQEIPIRSISLR;TLQEIYRKYR 2 6.1 0.96449 -1.2226 0 10.4844 0 0 6.03014 0 0 0 0 0 0 0 Q8N4B5 PRR18_HUMAN Proline-rich protein 18 PRR18 Homo sapiens (Human) HRYDDVEYEEEPEAVDEGLVRK 1 7.5 0.56226 0.18276 12.3615 0 0 0 0 0 0 0 0 0 0 0 Q8N4C6 NIN_HUMAN Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) NIN KIAA1565 Homo sapiens (Human) centriole-centriole cohesion [GO:0010457]; centrosome localization [GO:0051642]; centrosome-templated microtubule nucleation [GO:0090222]; collateral sprouting [GO:0048668]; corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; microtubule anchoring at centrosome [GO:0034454]; positive regulation of axonogenesis [GO:0050772]; protein localization [GO:0008104] apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; microtubule minus-end binding [GO:0051011] DLQEQQREEK;ELQEGREK;ELREREEVLCQAGASEQLASQR;ELTAEVFRLQDELKK;HFQHQATIAELELEKTK;HTLEKEELR;HVLSDLEDDEVR;IENEGLNVLVLRLQGKIEK;LELEDKVR;LQEVCEDLGITR;LTEMLCQK;LTEMLCQKEK;YVRGGKR 13 7.1 0.97779 -5.9665 0 0 0 13.4193 10.9048 9.17363 11.9729 9.96314 11.4971 12.7129 11.595 14.6014 Q8N4C7 STX19_HUMAN Syntaxin-19 STX19 Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] NPCRVLCCWCCPCCSSK;VLCCWCCPCCSSK 2 5.8 0.72248 0.13233 0 0 3.5287 5.1343 0 0 0 0 0 0 0 8.17572 Q8N4C8 MINK1_HUMAN Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) MINK1 B55 MAP4K6 MINK YSK2 ZC3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; regulation of cell migration [GO:0030334]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of MAPK cascade [GO:0043408] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALFLIPR;FIDFIDTCLIK;FPFIRDQPTER;LDQLQYDVR;SSVEVYAWAPKPYHK 5 4 0.97221 -1.3577 11.1193 0 0 0 0 10.5532 0 0 0 10.0018 0 0 Q8N4C9 CQ078_HUMAN Uncharacterized protein C17orf78 C17orf78 Homo sapiens (Human) membrane [GO:0016020] NLRIIAAPR;VGQDAANSSNPK;VNLVYLERRPKVK 3 12.4 0.94194 -0.61895 0 0 0 0 7.60933 0 7.63938 0 8.95327 0 0 0 Q8N4E4 PDCL2_HUMAN Phosducin-like protein 2 PDCL2 Homo sapiens (Human) acrosome assembly [GO:0001675]; protein folding [GO:0006457]; sperm axoneme assembly [GO:0007288]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783] KDMVDMMVSSIR 1 5 0.88134 -0.14841 0 0 0 0 0 0 0 0 0 0 10.6597 0 Q8N4E7 FTMT_HUMAN "Ferritin, mitochondrial (EC 1.16.3.1)" FTMT Homo sapiens (Human) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron ion binding [GO:0005506] QNFHPDSEAAINR 1 5.4 0.80449 0.013493 0 0 0 0 9.11301 0 0 0 0 0 0 0 Q8N4F4 S22AO_HUMAN Steroid transmembrane transporter SLC22A24 (Solute carrier family 22 member 24) SLC22A24 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; steroid metabolic process [GO:0008202]; sterol transmembrane transport [GO:0035382] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] NIKQEDTCMK;VGRKIICK 2 3.3 0.98073 -1.6751 0 0 0 0 0 0 0 8.48014 0 0 0 0 Q8N4H0 SPA6L_HUMAN Spermatogenesis associated 6-like protein SPATA6L C9orf68 Homo sapiens (Human) spermatogenesis [GO:0007283] sperm head-tail coupling apparatus [GO:0120212] myosin light chain binding [GO:0032027] LTPSHPR 1 1.8 0.91035 -0.31977 0 0 0 0 0 0 0 0 9.94971 0 0 0 Q8N4H5 TOM5_HUMAN Mitochondrial import receptor subunit TOM5 homolog TOMM5 C9orf105 TOM5 Homo sapiens (Human) protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] EDVISSIRNFLIYVALLR;LDPEEMK 2 49 0.95183 -0.68143 9.24854 0 0 0 0 0 0 10.8611 0 0 0 0 Q8N4J0 CARME_HUMAN Carnosine N-methyltransferase (EC 2.1.1.22) CARNMT1 C9orf41 Homo sapiens (Human) carnosine metabolic process [GO:0035498]; L-histidine catabolic process [GO:0006548]; methylation [GO:0032259] cytosol [GO:0005829]; nucleus [GO:0005634] carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] LEREHFWKIINAFR;VNRTERQFR;YYYECVLFVVR 3 8.3 0.955 -0.97007 9.17495 8.57969 0 8.92955 0 0 0 0 0 0 0 0 Q8N4L1 T151A_HUMAN Transmembrane protein 151A TMEM151A TMEM151 Homo sapiens (Human) axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] EEQRPLKQSLGSSLCRESHWK 1 4.5 0.95589 -0.98337 0 0 0 0 0 9.8045 0 0 0 0 0 0 Q8N4L4 SPEM1_HUMAN Spermatid maturation protein 1 SPEM1 C17orf83 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291] cytoplasm [GO:0005737]; membrane [GO:0016020] GVLYQVFHDTICEK 1 4.5 0.64104 0.17229 0 0 0 0 0 0 0 0 0 9.13011 0 0 Q8N4M1 CTL3_HUMAN Choline transporter-like protein 3 (Solute carrier family 44 member 3) SLC44A3 CTL3 UNQ558/PRO1115 Homo sapiens (Human) phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085] membrane [GO:0016020]; plasma membrane [GO:0005886] choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857] IIVMYMQNALK;LNNARAQQDK;LPVPPSK 3 4.3 0.97873 -1.911 0 7.10108 0 0 0 0 0 0 0 0 12.3632 10.7605 Q8N4M7 CJ126_HUMAN Putative uncharacterized protein C10orf126 C10orf126 Homo sapiens (Human) AGPGFHR 1 4.1 0.91226 -0.32289 0 0 0 6.5083 0 0 0 0 0 0 0 0 Q8N4N3 KLH36_HUMAN Kelch-like protein 36 KLHL36 C16orf44 Homo sapiens (Human) protein ubiquitination [GO:0016567] cullin family protein binding [GO:0097602] WADHSSTVLQRLNEQRLR 1 2.9 0.54799 0.18358 0 0 0 0 0 0 0 0 0 0 7.23132 0 Q8N4N8 KIF2B_HUMAN Kinesin-like protein KIF2B KIF2B Homo sapiens (Human) cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; regulation of chromosome segregation [GO:0051983] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ISVLEPPQEHR;KSPCLWEIQKLQEQR 2 3.9 0.98086 -1.6733 0 0 0 0 0 0 0 0 8.54917 0 11.5988 0 Q8N4P6 LRC71_HUMAN Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) QLLSPHFQGRK 1 3.1 0.91673 -0.42621 0 0 0 9.55957 0 0 0 0 0 0 0 0 Q8N4Q0 PTGR3_HUMAN Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) PTGR3 ZADH2 Homo sapiens (Human) lipid metabolic process [GO:0006629]; negative regulation of fat cell differentiation [GO:0045599] mitochondrion [GO:0005739]; peroxisome [GO:0005777] 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity [GO:0047522]; zinc ion binding [GO:0008270] LVPTGAR 1 1.9 0.90836 -0.30954 0 0 0 0 0 0 0 0 9.2706 0 0 0 Q8N4S0 CCD82_HUMAN Coiled-coil domain-containing protein 82 CCDC82 HT025 Homo sapiens (Human) nucleus [GO:0005634] MFHELFS;NSKSHVPEQKSR 2 5.5 0.98042 -1.6717 0 0 0 0 9.47822 0 0 0 0 0 0 0 Q8N4S7 PAQR4_HUMAN Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV) PAQR4 Homo sapiens (Human) protein stabilization [GO:0050821]; regulation of ceramide biosynthetic process [GO:2000303] Golgi membrane [GO:0000139] molecular adaptor activity [GO:0060090]; signaling receptor activity [GO:0038023] LLVFGAR 1 3.5 0.91281 -0.32242 0 0 0 7.886 0 0 0 0 0 0 0 0 Q8N4T0 CBPA6_HUMAN Carboxypeptidase A6 (EC 3.4.17.-) CPA6 CPAH Homo sapiens (Human) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] FIPKTEEEAYALK;FRCRGVDANR 2 5.3 0.87649 -0.12366 0 0 5.43866 0 0 0 0 0 0 7.87523 0 0 Q8N4T8 CBR4_HUMAN 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1) CBR4 SDR45C1 Homo sapiens (Human) daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204] "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; quinone binding [GO:0048038]" DLKEEHLK 1 3.4 0.98 -1.5683 0 0 0 0 0 0 0 0 0 0 10.209 0 Q8N4U5 T11L2_HUMAN T-complex protein 11-like protein 2 TCP11L2 Homo sapiens (Human) muscle cell migration [GO:0014812]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ISAVLLEGMNK;LQELTEK 2 3.5 0.91628 -0.34481 0 13.2362 0 0 8.79812 0 0 0 0 0 0 0 Q8N4U5 T11L2_HUMAN T-complex protein 11-like protein 2 TCP11L2 Homo sapiens (Human) muscle cell migration [GO:0014812]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] AEVAGAS 1 2.6 0.82328 -0.017959 9.30273 0 0 0 0 0 0 0 0 0 0 0 Q8N4V2 SVOP_HUMAN Synaptic vesicle 2-related protein (SV2-related protein) SVOP Homo sapiens (Human) xenobiotic transport [GO:0042908] basal plasma membrane [GO:0009925]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] IATENGAPMPLGK 1 2.4 0.93513 -0.52969 0 0 10.9416 0 0 0 0 0 0 0 0 0 Q8N4W9 ZN808_HUMAN Zinc finger protein 808 ZNF808 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of gene expression [GO:0010629]; pancreas development [GO:0031016]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" AFVRNSYLARHIR;AIHTGEKPYK;ASLVYHRR;CNECGKTFSYK;CTVCDKAFVRNSYLAR;GKESGMALPQGR 6 6.6 0.96639 -1.2622 0 12.5621 5.25346 0 8.96093 10.4666 0 0 0 0 10.9293 0 Q8N4X5 AF1L2_HUMAN Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) AFAP1L2 KIAA1914 XB130 Homo sapiens (Human) inflammatory response [GO:0006954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of interleukin-8 production [GO:0032757]; regulation of interleukin-6 production [GO:0032675]; regulation of mitotic cell cycle [GO:0007346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] protein tyrosine kinase activator activity [GO:0030296]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] EIDEECRGEESR;ELKETLLK;LSNLMNLGRK;STSLEPVER;VTSAEIK 5 5.6 0.97449 -3.5023 0 0 0 0 9.29531 0 0 0 8.431 0 11.4596 0 Q8N4Y2 EFC4A_HUMAN EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) CRACR2B EFCAB4A Homo sapiens (Human) store-operated calcium entry [GO:0002115] calcium ion binding [GO:0005509] ALYEETEQLR;AVRTLWARLQR;DGLEQALRR;EAKGFITK;LPGPTCCCCCCWARPPR 5 13.8 0.97954 -1.8422 4.31752 0 12.7628 8.68173 10.428 0 0 13.6715 0 0 3.94589 0 Q8N531 FBXL6_HUMAN F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A) FBXL6 FBL6 Homo sapiens (Human) proteolysis [GO:0006508]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] ubiquitin-protein transferase activity [GO:0004842] DLEQALAAFLSTPGGSHPALCSLNLR 1 4.8 0.81483 -0.00015066 0 0 0 0 0 0 0 0 0 0 5.49063 0 Q8N535 CB052_HUMAN Putative uncharacterized protein encoded by LINC00471 LINC00471 C2orf52 Homo sapiens (Human) NSELDQDEEDK 1 10.2 0.82868 -0.023583 0 0 9.34882 0 0 0 0 0 0 0 0 0 Q8N539 FBCD1_HUMAN Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] chitin binding [GO:0008061]; metal ion binding [GO:0046872] GLGRPRNK;MVNDRWK 2 3.3 0.97935 -1.8881 0 0 0 0 0 0 0 0 0 0 0 10.8739 Q8N554 ZN276_HUMAN Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) ZNF276 CENP-Z ZFP276 ZNF477 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; kinetochore [GO:0000776]; nucleus [GO:0005634] chromatin insulator sequence binding [GO:0043035]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] QDPTLSPFVCK 1 1.8 0.89652 -0.23455 0 0 0 0 0 9.3023 0 0 0 0 0 0 Q8N556 AFAP1_HUMAN Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) AFAP1 AFAP Homo sapiens (Human) regulation of signal transduction [GO:0009966] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; stress fiber [GO:0001725] actin binding [GO:0003779] RFGQWTK;YSPADRKASR 2 2.1 0.98119 -1.6999 0 0 0 13.5432 9.75131 0 0 14.4424 14.4583 0 0 13.9645 Q8N565 MREG_HUMAN Melanoregulin (Dilute suppressor protein homolog) MREG DSU HDCGA21P Homo sapiens (Human) melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; minus-end-directed organelle transport along microtubule [GO:0072385]; phagosome maturation [GO:0090382] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; organelle membrane [GO:0031090]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] LSTISDSKNTRK;TVCCCCGCECLEER;TVCCCCGCECLEERALPEK 3 14.5 0.95107 -0.69667 0 5.11107 4.51753 0 0 0 3.31079 12.573 0 0 6.88228 6.57563 Q8N568 DCLK2_HUMAN Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) DCLK2 DCAMKL2 DCDC3B DCK2 Homo sapiens (Human) hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of protein localization to nucleus [GO:1900181]; protein localization to nucleus [GO:0034504]; pyramidal neuron development [GO:0021860] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELISQMLQVNVEAR;LVTVIRSGVKPR 2 3.4 0.82592 -0.020585 0 3.64731 0 0 8.82448 0 0 0 0 0 0 0 Q8N573 OXR1_HUMAN Oxidation resistance protein 1 OXR1 Nbla00307 Homo sapiens (Human) adult walking behavior [GO:0007628]; cellular response to hydroperoxide [GO:0071447]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron apoptotic process [GO:0051402]; response to oxidative stress [GO:0006979] mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] oxidoreductase activity [GO:0016491] GNSDQDSFLHENSLHQEESQK;IDALNTEELRTLCR;MSVSNLSWLKK 3 5.3 0.893 -0.22058 0 4.94753 0 0 0 0 0 9.915 0 0 9.56879 0 Q8N584 TT39C_HUMAN Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) TTC39C C18orf17 Homo sapiens (Human) cilium assembly [GO:0060271]; otolith morphogenesis [GO:0032474] IYNKCYLDINALQELYQK;KSAPSMVDRLQR;LCESEEAGVIETIKNK 3 7.9 0.93713 -0.54329 0 0 0 4.07605 5.36019 7.31334 7.38258 0 0 0 0 10.5827 Q8N594 MPND_HUMAN MPN domain-containing protein (EC 3.4.-.-) MPND Homo sapiens (Human) double-strand break repair [GO:0006302]; proteolysis [GO:0006508] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552] metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593] RPLGKSPSEPAHPEATTPGK 1 4.2 0.81807 -0.01737 0 0 0 0 0 0 0 10.3776 0 0 0 11.0957 Q8N5A5 ZGPAT_HUMAN Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) ZGPAT GPATC6 GPATCH6 KIAA1847 ZC3H9 ZC3HDC9 ZIP Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AQEAGLQQEQRKADTHK;SLKPCPFFLEGK 2 5.5 0.97369 -1.403 0 0 9.19012 0 0 0 0 2.80103 11.771 0 0 8.85287 Q8N5B7 CERS5_HUMAN Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) CERS5 LASS5 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; oligodendrocyte development [GO:0014003]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] IQCWFRHR 1 2 0.98045 -1.5574 0 0 0 0 0 0 0 0 0 0 0 11.4568 Q8N5C1 CAHM5_HUMAN Calcium homeostasis modulator protein 5 (Protein FAM26E) CALHM5 C6orf188 FAM26E Homo sapiens (Human) ATP export [GO:1904669] plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] LSERNLK;TSMLPTVNEELK 2 6.1 0.95869 -1.0023 0 0 0 0 0 0 0 3.94035 0 0 0 0 Q8N5C6 SRBD1_HUMAN S1 RNA-binding domain-containing protein 1 SRBD1 Homo sapiens (Human) nucleobase-containing compound metabolic process [GO:0006139]; translation [GO:0006412] mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735] AMLNCKTFEELEHVSAPYK;ETEAYFADLIMK;HVCIQSSLAK;INQDYIR;LFNDDNTIPFIIRYRK;LTSDAEKESVMMFGR;NLCQKRHVCIQSSLAK;SFARPELMK;TLMGVDPGYK 9 10.5 0.97902 -1.9134 0 0 0 0 0 9.85978 0 0 11.3923 0 13.8782 0 Q8N5C7 DTWD1_HUMAN tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1) DTWD1 MDS009 Homo sapiens (Human) tRNA modification [GO:0006400] nucleus [GO:0005634] tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432] STAIHAK;TEEQEFCDLNDSKCK 2 7.2 0.71597 0.13748 0 0 5.72792 0 0 0 0 6.32867 0 8.94723 8.58579 0 Q8N5C8 TAB3_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) TAB3 MAP3K7IP3 Homo sapiens (Human) defense response to bacterium [GO:0042742]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] KDSSDPCTIER 1 1.5 0.67887 0.16561 0 0 0 0 0 0 0 0 0 6.06979 0 0 Q8N5D0 WDTC1_HUMAN WD and tetratricopeptide repeats protein 1 WDTC1 KIAA1037 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; intracellular chemical homeostasis [GO:0055082]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826] AISLNPCHLK;APHNAMLYGNR;MIHNHRK 3 4.1 0.9727 -1.3648 0 0 0 0 9.87267 0 0 0 0 0 8.47005 0 Q8N5D6 GBGT1_HUMAN "Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.-) (Forssman glycolipid synthase-like protein)" GBGT1 UNQ2513/PRO6002 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycolipid biosynthetic process [GO:0009247]; lipid glycosylation [GO:0030259]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; vesicle [GO:0031982] globoside alpha-N-acetylgalactosaminyltransferase activity [GO:0047277]; metal ion binding [GO:0046872] EVDYLFCLDVDMVFR 1 4.3 0.78438 0.02666 0 0 9.82812 0 0 0 0 0 0 0 0 0 Q8N5F7 NKAP_HUMAN NF-kappa-B-activating protein NKAP Homo sapiens (Human) granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; RNA binding [GO:0003723] APVSGSR;ILASFREMVYR;YSEDSDSDSDSETDSSDEDNK 3 9.4 0.92777 -0.45761 3.04478 0 11.9808 0 0 0 0 0 0 8.03227 0 0 Q8N5G0 SIM20_HUMAN Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)] SMIM20 C4orf52 MITRAC7 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617] extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] TALIFGGFISLIGAAFYPIYFRPLMRLEEYK;VWSDPFGRK 2 59.7 0.95733 -1.0291 7.86907 7.04078 0 0 0 0 0 0 0 0 0 0 Q8N5G2 MACOI_HUMAN Macoilin (Macoilin-1) (Transmembrane protein 57) MACO1 TMEM57 Homo sapiens (Human) brain development [GO:0007420]; chemotaxis [GO:0006935]; neuronal signal transduction [GO:0023041] axon [GO:0030424]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; rough endoplasmic reticulum membrane [GO:0030867]; synapse [GO:0045202] microtubule binding [GO:0008017] ITEGIYGRLEQDIK;LTMDMKVK;LTMDMKVKEDQIR 3 8.8 0.97861 -2.1047 0 0 0 0 0 10.0146 0 0 8.7496 11.0441 0 0 Q8N5H3 LRA25_HUMAN Leucine repeat adapter protein 25 FAM89B Lrap25 Homo sapiens (Human) establishment of cell polarity [GO:0030010]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] transcription corepressor binding [GO:0001222] ELERVYSQR 1 4.8 0.97502 -1.4425 0 0 0 0 0 0 10.0438 0 0 0 0 0 Q8N5H7 SH2D3_HUMAN SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) SH2D3C NSP3 UNQ272/PRO309/PRO34088 Homo sapiens (Human) JNK cascade [GO:0007254]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] FKGFGSLSNLPR;KLKPFLKSLNEGK;LHKELEEELKLSSTDLR;YHVGSRKAVSEQSGAIIYCPVNR 4 7.6 0.96742 -1.2959 0 0 0 5.58589 0 0 0 8.67899 0 5.32312 0 0 Q8N5I3 KCNRG_HUMAN Potassium channel regulatory protein (Potassium channel regulator) (Protein CLLD4) KCNRG CLLD4 Homo sapiens (Human) negative regulation of delayed rectifier potassium channel activity [GO:1902260]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783] identical protein binding [GO:0042802] TVSSEDK 1 2.6 0.90943 -0.31445 0 0 0 0 0 0 0 0 0 0 9.63827 0 Q8N5I4 DHRSX_HUMAN Polyprenol dehydrogenase (EC 1.3.-.-) (DHRSXY) (Dehydrogenase/reductase SDR family member on chromosome X) (Dolichal reductase) (EC 1.3.-.-) DHRSX CXorf11 DHRS5X SDR46C1 SDR7C6 UNQ6508/PRO21433 Homo sapiens (Human) dolichol biosynthetic process [GO:0019408]; positive regulation of autophagy [GO:0010508] extracellular region [GO:0005576]; lipid droplet [GO:0005811] dolichal reductase activity [GO:0160197]; polyprenol dehydrogenase activity [GO:0160196] AALRVYAVGAAVILAQLLRR;SLHVTYNQK;SPLSAAR 3 10.9 0.96242 -1.0768 12.3285 0 4.18888 0 0 7.09424 0 0 4.7967 0 0 0 Q8N5I9 NOPC1_HUMAN NOP protein chaperone 1 NOPCHAP1 C12orf45 Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492] nucleus [GO:0005634] box C/D methylation guide snoRNP complex binding [GO:0062064] GGIWDRLLINSQPK 1 7.6 0.88739 -0.18279 0 0 0 0 0 0 0 0 0 0 7.81948 0 Q8N5J2 MINY1_HUMAN Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A) MINDY1 FAM63A KIAA1390 Homo sapiens (Human) proteolysis [GO:0006508] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435] EYHQPEDPAPGK 1 2.6 0.80878 0.010713 0 0 5.66292 0 0 0 0 0 0 0 0 0 Q8N5K1 CISD2_HUMAN CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) CISD2 CDGSH2 ERIS ZCD2 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; regulation of autophagy [GO:0010506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear endoplasmic reticulum [GO:0097038]; protein-containing complex [GO:0032991] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]" AAYCRCWRSK;LLPFLGVLALLGYLAVRPFLPK 2 23.7 0.75656 0.073545 0 9.11775 0 0 7.71026 0 0 0 0 7.32688 0 9.8107 Q8N5M4 TTC9C_HUMAN Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) TTC9C Homo sapiens (Human) EEGNQRYR;EGKYRDAVSR;RLQEAQLYKEEGNQR;YLQLTQSELSSYHR 4 24 0.792 0.01634 0 0 8.78895 0 0 0 0 0 0 0 0 0 Q8N5M4 TTC9C_HUMAN Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) TTC9C Homo sapiens (Human) ALLEFFGKSHPPPHRLFR;EEGNQRYR;EGKYRDAVSR;RLQEAQLYKEEGNQR 4 20.9 0.97236 -2.6841 0 8.12866 0 10.9977 8.29154 0 0 0 0 0 0 0 Q8N5N4 CC022_HUMAN Uncharacterized protein C3orf22 C3orf22 Homo sapiens (Human) RFPRQLAFLLSTR 1 9.2 0.86825 -0.093886 0 0 0 0 0 0 0 0 0 0 4.03333 0 Q8N5P1 ZC3H8_HUMAN Zinc finger CCCH domain-containing protein 8 ZC3H8 ZC3HDC8 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T cell differentiation in thymus [GO:0033085]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase III [GO:0045945]; response to antibiotic [GO:0046677]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; T cell homeostasis [GO:0043029] Cajal body [GO:0015030]; chromatin [GO:0000785]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]" CYQGEYCK 1 2.7 0.9144 -0.39033 0 0 0 0 0 0 3.96671 0 0 0 0 5.934 Q8N5Q1 GAR5B_HUMAN Golgi-associated RAB2 interactor protein 5B GARIN5B C19orf16 FAM71E2 Homo sapiens (Human) TPPPSQK;VPFRSKPTSASLK 2 2.2 0.95894 -1.0331 0 0 0 0 0 0 0 0 0 0 0 10.9848 Q8N5R6 CCD33_HUMAN Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) CCDC33 Homo sapiens (Human) peroxisome [GO:0005777] ALEETVR;DGSEPWPYVVVKSTSEEK;GLDGLHVER;LDEPLGRAAQR;LLLSELDMKKLR 5 5.9 0.98028 -1.6563 0 0 0 0 0 0 10.8757 12.6122 10.6613 10.4394 0 0 Q8N5S1 S2541_HUMAN Mitochondrial carrier protein SCaMC-3L (Mitochondrial ATP-Mg/Pi carrier protein SLC25A41) (Small calcium-binding mitochondrial carrier protein 3-like) (SCaMC-3-like) (SCaMC-3L) (Solute carrier family 25 member 41) SLC25A41 Homo sapiens (Human) ADP transport [GO:0015866]; ATP transport [GO:0015867]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347] ITSVEYKGPRPSR 1 5.4 0.91799 -0.40551 0 0 0 0 0 0 0 0 0 0 0 11.4376 Q8N5S3 CMIP6_HUMAN Ciliary microtubule inner protein 6 CIMIP6 C2orf73 Homo sapiens (Human) HGAFVQREIKPGSRPTVPK 1 11.4 0.8232 -0.018923 0 0 0 0 0 0 0 7.00753 0 0 0 0 Q8N5S9 KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) CAMKK1 CAMKKA Homo sapiens (Human) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] LIPSWTTVILVKSMLR 1 3.2 0.92076 -0.43731 0 0 0 0 2.81791 0 0 0 0 0 0 0 Q8N5T2 TBC19_HUMAN TBC1 domain family member 19 TBC1D19 Homo sapiens (Human) GTPase activator activity [GO:0005096] EIGAQPLRISFK;ISGWEKK 2 3.6 0.94532 -0.6437 0 11.7759 0 0 0 0 2.96886 0 0 0 0 0 Q8N5U6 RNF10_HUMAN E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) RNF10 KIAA0262 RIE2 Homo sapiens (Human) negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse to nucleus signaling pathway [GO:0099527]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630] AEFSPAQFSGPK;EYGSLER;RDEVAEAQRAEFSPAQFSGPK;SVVATESHQYVVGDTITMQLMKREK 4 6.5 0.96472 -1.2278 0 0 10.5852 0 0 6.71397 3.77663 0 0 0 0 0 Q8N5V2 NGEF_HUMAN Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) NGEF Homo sapiens (Human) cell differentiation [GO:0030154]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] LKLLVQNILKR;SVPIISHSR 2 2.8 0.9344 -0.50338 0 0 0 0 0 0 0 0 0 10.3377 10.253 0 Q8N5W8 FA24B_HUMAN Protein FAM24B FAM24B Homo sapiens (Human) extracellular region [GO:0005576] PVIAGGILAALLLLIVVVLCLYFKIHNALK 1 31.9 0.84183 -0.045328 0 0 0 0 0 0 0 0 0 0 0 4.87342 Q8N5W9 RFLB_HUMAN Refilin-B (Regulator of filamin protein B) (RefilinB) RFLNB Homo sapiens (Human) actin filament bundle organization [GO:0061572]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705] actin filament bundle [GO:0032432]; cytoplasm [GO:0005737] filamin binding [GO:0031005] MVGRLSLQDVPELVDAK;VGRLSLQDVPELVDAKK 2 8.4 0.89684 -0.23701 10.6478 0 0 0 0 0 0 0 0 0 0 0 Q8N5Y2 MS3L1_HUMAN MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) MSL3 MSL3L1 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] DENDENSLSSSSDCSENK;IPEYLIHFNGWNRSWDR;QLEDDCYYINR 3 8.8 0.93606 -0.51901 0 0 0 0 9.18822 0 0 0 7.55873 0 0 0 Q8N5Z5 KCD17_HUMAN BTB/POZ domain-containing protein KCTD17 KCTD17 Homo sapiens (Human) cell projection organization [GO:0030030]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; positive regulation of cilium assembly [GO:0045724]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783] cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AAGGWGK 1 2.2 0.70301 0.16061 0 0 0 0 0 0 0 0 8.15249 8.74715 8.55815 0 Q8N608 DPP10_HUMAN Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2) DPP10 DPRP3 KIAA1492 Homo sapiens (Human) positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]; transmembrane transporter binding [GO:0044325] QCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPR;YLGMPSK 2 5.2 0.95215 -0.74494 0 0 0 0 0 0 0 8.18606 0 0 10.6998 0 Q8N612 FHI1B_HUMAN FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) FHIP1B C11orf56 FAM160A2 KIAA1759 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] FHF complex [GO:0070695] MNWLSRLASR;SRRPSLGELLLR 2 2.3 0.98158 -1.7718 0 0 0 0 0 0 0 12.0891 0 0 0 0 Q8N612 FHI1B_HUMAN FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) FHIP1B C11orf56 FAM160A2 KIAA1759 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] FHF complex [GO:0070695] LTLLAEDR 1 1.1 0.93023 -0.46951 0 0 0 10.1585 0 0 0 0 0 0 0 0 Q8N614 TM156_HUMAN Transmembrane protein 156 TMEM156 Homo sapiens (Human) membrane [GO:0016020] ITWYILVLLVFIFLIILTIR;LFVAIVITFILILPEYFKTPK;NITCSMK;SINYTCR;TKTALLKLFVAIVITFILILPEYFK 5 20.9 0.95391 -0.92385 0 0 0 8.40506 0 0 0 0 0 9.19808 5.71433 9.96554 Q8N616 TM148_HUMAN Putative uncharacterized protein encoded by LINC00311 LINC00311 NCRNA00311 TMEM148 Homo sapiens (Human) TLFWSEWAR 1 7.6 0.90816 -0.30284 0 0 0 9.38619 0 0 0 0 0 0 0 0 Q8N635 MEIOB_HUMAN Meiosis-specific with OB domain-containing protein (EC 3.1.-.-) MEIOB C16orf73 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; female meiosis I [GO:0007144]; fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; resolution of meiotic recombination intermediates [GO:0000712] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] chromatin binding [GO:0003682]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697] EIEREEKFSPATPSNCK;LADPTEASRNLSGQK 2 7.2 0.93361 -0.50265 0 0 7.5216 0 5.1778 0 0 8.56232 0 0 0 0 Q8N653 LZTR1_HUMAN Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 TCFL2 Homo sapiens (Human) negative regulation of Ras protein signal transduction [GO:0046580]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; recycling endosome membrane [GO:0055038] small GTPase binding [GO:0031267] AILAARSSYFEAMFR 1 1.8 0.91758 -0.42852 0 0 0 9.32933 0 0 0 0 0 0 0 0 Q8N680 ZBTB2_HUMAN Zinc finger and BTB domain-containing protein 2 ZBTB2 KIAA1483 ZNF437 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RNGSFPKYYACHLCGR 1 3.1 0.85003 -0.075876 0 0 0 0 6.45212 0 0 0 0 0 0 0 Q8N684 CPSF7_HUMAN Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) CPSF7 Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" cytoplasm [GO:0005737]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] AISSSAISK;ASAPYNHHGSR;DLLHNEDRHDDYFQERNR;QNLSQFEAQAR;QNLSQFEAQARK 5 10.6 0.93568 -0.52193 0 0 0 0 7.14985 0 9.04712 11.0142 11.7614 10.6247 12.5355 0 Q8N688 DB123_HUMAN "Beta-defensin 123 (Beta-defensin 23) (DEFB-23) (Defensin, beta 123)" DEFB123 DEFB23 UNQ1963/PRO4485 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular region [GO:0005576] KERVYVYCINNK 1 17.9 0.86689 -0.09177 0 0 0 0 0 0 0 0 8.27282 0 0 0 Q8N690 DB119_HUMAN "Beta-defensin 119 (Beta-defensin 120) (Beta-defensin 19) (DEFB-19) (Beta-defensin 20) (DEFB-20) (Defensin, beta 119) (Defensin, beta 120) (ESC42-RELA)" DEFB119 DEFB120 DEFB19 DEFB20 UNQ2449/PRO5729 Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576] KLLYLFLAILLAIEEPVISGK 1 25 0.60451 0.17675 0 0 4.58231 0 0 0 0 0 0 0 0 0 Q8N695 SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) acetate transport [GO:0006846]; apoptotic process [GO:0006915]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; monoatomic ion transport [GO:0006811]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886] iodide channel activity [GO:0160081]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552] EDFLSNFDIFKKK;YILTKEDFLSNFDIFK 2 3 0.98022 -1.6428 0 0 0 0 10.0848 0 0 0 0 0 0 0 Q8N699 MYCT1_HUMAN Myc target protein 1 (Myc target in myeloid cells protein 1) MYCT1 MTLC MTMC1 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484] intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] HSGCERRSNLSLASLTFQR 1 8.1 0.49701 0.18922 0 0 0 0 7.39951 0 0 0 0 0 0 0 Q8N6C5 IGSF1_HUMAN Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120) IGSF1 IGDC1 KIAA0364 PGSF2 Homo sapiens (Human) immune response-regulating signaling pathway [GO:0002764]; negative regulation of activin receptor signaling pathway [GO:0032926]; regulation of DNA-templated transcription [GO:0006355] extracellular region [GO:0005576]; membrane [GO:0016020] activin receptor antagonist activity [GO:0038102]; inhibin binding [GO:0034711] GQELQLR;LSLIMQLVALLLVVLWIR;NLTLWCR;VEDLEKSFYHK 4 3.2 0.97247 -1.3661 6.67483 0 0 0 0 0 9.01645 11.0374 0 3.47483 0 0 Q8N6F1 CLD19_HUMAN Claudin-19 CLDN19 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; neuronal action potential propagation [GO:0019227]; paracellular transport [GO:0160184]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transepithelial transport [GO:0150111]; renal absorption [GO:0070293]; retinal pigment epithelium development [GO:0003406]; visual perception [GO:0007601] apical junction complex [GO:0043296]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; mesaxon [GO:0097453]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160] identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] VGDSNPIAKGR 1 5.2 0.98037 -1.5571 0 0 0 0 0 0 0 0 0 0 0 10.2838 Q8N6G2 TEX26_HUMAN Testis-expressed protein 26 TEX26 C13orf26 Homo sapiens (Human) cytoplasm [GO:0005737] EDLIKTETSRGIK 1 4.5 0.95914 -1.0384 0 0 0 0 9.85365 0 0 0 0 0 0 0 Q8N6G5 CGAT2_HUMAN "Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)" CSGALNACT2 CHGN2 GALNACT2 PRO0082 Homo sapiens (Human) "chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050652]; proteoglycan biosynthetic process [GO:0030166]" Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872] HVTLFRPFGPLMKVK;QAYRTNSEAVG;QELQEMSEKMR 3 6.8 0.97751 -2.1706 0 0 3.31488 10.3319 0 0 7.32184 0 0 0 0 0 Q8N6G6 ATL1_HUMAN ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) extracellular matrix organization [GO:0030198] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] hydrolase activity [GO:0016787] EDNCGVCNGDGSTCR;LLEQGGWPGELLASWEAQDSAER;RVECVHARTNK 3 2.8 0.97848 -1.9357 0 0 0 0 0 0 0 0 0 3.09776 0 0 Q8N6I1 EID2_HUMAN EP300-interacting inhibitor of differentiation 2 (EID-2) (CREBBP/EP300 inhibitor 2) (EID-1-like inhibitor of differentiation 2) EID2 CRI2 Homo sapiens (Human) cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of cell population proliferation [GO:0042127]; transforming growth factor beta receptor complex assembly [GO:0007181] nucleoplasm [GO:0005654]; nucleus [GO:0005634] SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714] IQELEERR 1 3.4 0.91363 -0.38547 0 0 0 0 0 0 0 0 0 0 0 9.96551 Q8N6K0 TEX29_HUMAN Testis-expressed protein 29 TEX29 C13orf16 Homo sapiens (Human) membrane [GO:0016020] AIPVDVALPQK;MEYVLEVK 2 12.6 0.88071 -0.16909 0 0 0 0 9.83422 0 0 0 0 0 0 3.87706 Q8N6K7 SAMD3_HUMAN Sterile alpha motif domain-containing protein 3 (SAM domain-containing protein 3) SAMD3 Homo sapiens (Human) TEKDWREIDK;WFQQEYVK 2 3.5 0.98036 -1.6423 0 0 0 0 0 0 8.96049 0 0 0 0 0 Q8N6L0 KASH5_HUMAN Protein KASH5 (Coiled-coil domain-containing protein 155) (KASH domain-containing protein 5) KASH5 CCDC155 Homo sapiens (Human) actin filament organization [GO:0007015]; chromosome localization to nuclear envelope involved in homologous chromosome segregation [GO:0090220]; double-strand break repair via homologous recombination [GO:0000724]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; spindle assembly [GO:0051225]; spindle localization [GO:0051653]; telomere localization [GO:0034397] "chromosome, telomeric region [GO:0000781]; lateral element [GO:0000800]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; meiotic spindle pole [GO:0090619]; nuclear outer membrane [GO:0005640]" dynein complex binding [GO:0070840]; identical protein binding [GO:0042802] KEPSMWLTR;LLAERDGVK;LVGENAK 3 4.4 0.97983 -1.5647 0 0 0 0 0 0 9.70202 12.0684 11.9812 11.5098 11.2493 0 Q8N6M0 OTU6B_HUMAN Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B) OTUD6B DUBA5 CGI-77 Homo sapiens (Human) cell population proliferation [GO:0008283]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]; proteasome assembly [GO:0043248]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] LEKEMEQK;LTTKENK;NAVPKNDKK 3 8.2 0.97221 -2.8353 13.1288 0 0 0 0 0 0 0 0 0 0 0 Q8N6M3 FITM2_HUMAN Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2) FITM2 C20orf142 FIT2 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; fatty-acyl-CoA catabolic process [GO:0036115]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of cell morphogenesis [GO:0022604]; regulation of triglyceride biosynthetic process [GO:0010866]; sequestering of triglyceride [GO:0030730] endoplasmic reticulum membrane [GO:0005789] coenzyme A diphosphatase activity [GO:0010945]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129] ELSPLPESYLSNKRNVLNVYFVK 1 8.8 0.95616 -0.99588 0 0 11.9221 0 0 0 0 0 0 0 0 0 Q8N6M6 AMPO_HUMAN Aminopeptidase O (AP-O) (EC 3.4.11.-) AOPEP C9orf3 ONPEP Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleolus [GO:0005730] metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] FLQEDQAMGVYLYGELMVSEDARQQQLARR;HRWCELIVKHK 2 5 0.75897 0.071607 0 0 0 0 11.2921 1.53998 0 0 0 0 0 0 Q8N6M8 IQCF1_HUMAN IQ domain-containing protein F1 IQCF1 Homo sapiens (Human) positive regulation of acrosome reaction [GO:2000344]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474] acrosomal vesicle [GO:0001669] calmodulin binding [GO:0005516] LILSKILK;LILSKILKK;QAALEAFSRKEWAAVTLQSQAR;TPVLVETQTVDNANEKSEKPPENQKK 4 27.8 0.96571 -1.132 0 0 0 9.95514 0 3.36275 0 0 10.5806 0 10.0615 9.52052 Q8N6M9 ZFN2A_HUMAN AN1-type zinc finger protein 2A ZFAND2A Homo sapiens (Human) cellular response to arsenic-containing substance [GO:0071243]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to ER [GO:0045047] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; proteasome complex [GO:0000502] zinc ion binding [GO:0008270] DCDSHPGK;MEFPDLGKHCSEK 2 14.5 0.95615 -0.83995 0 0 7.39318 0 0 0 0 0 0 0 5.0502 0 Q8N6N7 ACBD7_HUMAN Acyl-CoA-binding domain-containing protein 7 ACBD7 Homo sapiens (Human) fatty acid metabolic process [GO:0006631] fatty-acyl-CoA binding [GO:0000062] ARPDDGELKELYGLYK;ELYGLYK 2 18.2 0.94146 -0.60447 0 5.1382 0 0 0 0 0 0 0 0 0 0 Q8N6Q1 TMC5A_HUMAN Transmembrane and coiled-coil domain-containing protein 5A TMCO5A TMCO5 Homo sapiens (Human) membrane [GO:0016020] EVSKLVSMNPVEK;TLVHSITELQQKLTR;VLGRSTLWK 3 12.8 0.97484 -3.111 6.33464 0 0 0 0 0 0 0 5.36373 0 0 0 Q8N6Q3 CD177_HUMAN CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177) CD177 NB1 PRV1 UNQ595/PRO1181 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell junction maintenance [GO:0045217]; innate immune response [GO:0045087]; leukocyte cell-cell adhesion [GO:0007159]; neutrophil extravasation [GO:0072672]; neutrophil migration [GO:1990266]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of superoxide anion generation [GO:0032930]; protein localization to cell surface [GO:0034394]; regulation of endocytosis [GO:0030100]; regulation of integrin-mediated signaling pathway [GO:2001044] extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; protease binding [GO:0002020] GQGQHQCVQLDWQK 1 5.6 0.89821 -0.23503 0 0 0 0 0 0 0 0 0 0 8.82206 0 Q8N6Q8 MET25_HUMAN Probable methyltransferase-like protein 25 (EC 2.1.1.-) METTL25 C12orf26 Homo sapiens (Human) methylation [GO:0032259] methyltransferase activity [GO:0008168] CSSFLDYVR;KHWKLCHAQSR 2 3.3 0.97283 -1.3703 0 0 0 0 0 0 0 0 0 10.6582 0 0 Q8N6R0 EFNMT_HUMAN eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] METTL13 EEF1AKNMT FEAT KIAA0859 CGI-01 Homo sapiens (Human) methylation [GO:0032259] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] protein-lysine N-methyltransferase activity [GO:0016279] AVGHFSR;LAEAVQER;MLAEVGRVLQVGGR 3 4.1 0.98084 -1.6866 0 0 0 0 0 0 0 0 9.97885 0 0 0 Q8N6S4 AN13C_HUMAN Ankyrin repeat domain-containing protein 13C ANKRD13C Homo sapiens (Human) protein retention in ER lumen [GO:0006621]; regulation of anoikis [GO:2000209]; regulation of signaling receptor activity [GO:0010469] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] signaling receptor binding [GO:0005102] RPRLLKALK;VTALLRKLK 2 3.6 0.84654 -0.060704 0 2.12363 0 0 0 0 0 0 0 3.74093 0 0 Q8N6S5 AR6P6_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) ARL6IP6 PFAAP1 Homo sapiens (Human) nuclear inner membrane [GO:0005637] DLRAEFSAGAWSEPRK 1 7.1 0.43893 0.1946 0 0 0 0 0 8.97424 0 0 0 0 0 0 Q8N6T0 TO6BL_HUMAN Type 2 DNA topoisomerase 6 subunit B-like (TOP6B like initiator of meiotic double strand breaks) (Type 2 DNA topoisomerase VI subunit B-like) (TOPOVIBL) TOP6BL C11orf80 Homo sapiens (Human) meiotic DNA double-strand break formation [GO:0042138]; reciprocal meiotic recombination [GO:0007131] chromosome [GO:0005694] AADTQEFR;VLEQHHQAAK;VLEQHHQAAKAADTQEFR 3 3.7 0.96663 -1.2819 0 0 0 5.49288 0 0 0 0 0 9.33646 9.15484 0 Q8N6T3 ARFG1_HUMAN ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] YVGFGNTPPPQKK 1 3.2 0.65461 0.16965 0 0 0 0 0 9.10946 0 0 0 0 0 0 Q8N6U8 GP161_HUMAN G-protein coupled receptor 161 (G-protein coupled receptor RE2) GPR161 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621] ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; glial cell projection [GO:0097386]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] G protein-coupled receptor activity [GO:0004930] GVGRSGHAPR;SLDSYAASLAK;VARVKAR 3 6.2 0.91312 -0.38249 0 0 0 0 0 0 11.4184 0 0 9.97355 0 0 Q8N6V9 TEX9_HUMAN Testis-expressed protein 9 TEX9 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] SCDDEDDYSLR 1 2.8 0.80608 0.0083013 0 0 0 0 0 0 6.07444 0 0 0 0 0 Q8N6W0 CELF5_HUMAN CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5) CELF5 BRUNOL5 Homo sapiens (Human) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002] DLKPLFEQFGR;LFVGQIPR 2 3.9 0.93989 -0.57819 0 0 0 0 0 0 0 0 0 0 12.7459 0 Q8N6Y2 LRC17_HUMAN Leucine-rich repeat-containing protein 17 (p37NB) LRRC17 P37NB UNQ3076/PRO9909 Homo sapiens (Human) bone marrow development [GO:0048539]; negative regulation of osteoclast differentiation [GO:0045671]; ossification [GO:0001503] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] NLGNYAK;VVTIVILLCFCKAAELRK 2 5.7 0.93094 -0.48955 0 0 0 0 0 0 0 0 0 0 0 11.9462 Q8N715 CC185_HUMAN Coiled-coil domain-containing protein 185 CCDC185 C1orf65 Homo sapiens (Human) DLWEPPRPGGERESTQRLGGQR;EKAQKEEEQLQQAR;FKRHSACVCAQK;LVEACRKR 4 9 0.96442 -1.1711 0 0 9.53091 0 0 10.0417 0 0 10.7493 0 10.8666 0 Q8N720 ZN655_HUMAN Zinc finger protein 655 (Vav-interacting Krueppel-like protein) ZNF655 VIK Homo sapiens (Human) negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVMLENYGNVVSLGILLRLPTTR 1 12.7 0.94431 -0.63462 0 0 0 0 0 0 11.7825 0 10.8006 0 0 0 Q8N726 ARF_HUMAN Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) CDKN2A CDKN2 MLM Homo sapiens (Human) "amyloid fibril formation [GO:1990000]; apoptotic signaling pathway [GO:0097190]; autophagy of mitochondrion [GO:0000422]; cellular senescence [GO:0090398]; mitochondrial depolarization [GO:0051882]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of protein neddylation [GO:2000435]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nuclear body organization [GO:0030575]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein localization to nucleolus [GO:1902570]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; regulation of cell cycle [GO:0051726]; regulation of protein export from nucleus [GO:0046825]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; rRNA processing [GO:0006364]; somatic stem cell division [GO:0048103]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin-protein transferase inhibitor activity [GO:0055105] GAAGRAR;SQRLGQQPLPR 2 13.6 0.97359 -1.4103 0 9.28993 8.91034 10.7121 0 0 0 0 0 0 0 0 Q8N729 NPW_HUMAN Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)] NPW PPL8 PPNPW Homo sapiens (Human) feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] G protein-coupled receptor binding [GO:0001664] LALLLLLLLLPLPSGAWYKHVASPR 1 15.2 0.83843 -0.039211 0 0 0 0 3.47379 0 0 0 0 0 0 0 Q8N752 KC1AL_HUMAN Casein kinase I isoform alpha-like (CKI-alpha-like) (EC 2.7.11.1) (CK1) CSNK1A1L Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IEYVHTKNFLHR;QHIPYREDK;TVLMLADQMISR 3 9.8 0.92416 -0.44798 0 0 0 0 0 0 0 10.3411 0 0 0 0 Q8N766 EMC1_HUMAN ER membrane protein complex subunit 1 EMC1 KIAA0090 PSEC0263 Homo sapiens (Human) protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein-containing complex [GO:0032991] DDSVGYRALVQTEDHLLLFLQQLGKVVLWSR 1 3.1 0.66802 0.1687 7.21072 6.15348 0 0 0 0 0 0 0 0 0 0 Q8N782 ZN525_HUMAN Zinc finger protein 525 ZNF525 KIAA1979 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNECGKTFSQK;HERHHIGDFSFQEIEK;MREKSFQCIESGK;TLYRDVMLENYR;YLARHRR 5 12.3 0.96126 -1.0619 0 0 6.25274 0 0 8.71651 0 0 0 10.4271 0 0 Q8N7A1 KLDC1_HUMAN Kelch domain-containing protein 1 KLHDC1 MSTP025 Homo sapiens (Human) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LIYFGGYGCRR;LSCWVYK;TQTWFQPEIK 3 6.9 0.95242 -0.73737 0 0 0 0 0 8.84112 8.14558 0 0 0 0 0 Q8N7B1 HORM2_HUMAN HORMA domain-containing protein 2 HORMAD2 Homo sapiens (Human) meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177] centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] VTEMYQFKFK 1 3.3 0.96425 -1.1714 0 0 0 0 0 0 0 12.3214 0 0 0 0 Q8N7B6 PACRL_HUMAN PACRG-like protein PACRGL C4orf28 Homo sapiens (Human) AIPLLPRLIPVLK 1 5.2 0.92426 -0.45041 0 3.7721 0 0 0 0 0 0 0 0 0 0 Q8N7B9 EFCB3_HUMAN EF-hand calcium-binding domain-containing protein 3 EFCAB3 Homo sapiens (Human) calcium ion binding [GO:0005509] AVSEIKPKLKLNPLTK 1 3.7 0.50253 0.18857 0 0 0 0 0 0 0 0 0 3.62831 0 0 Q8N7C3 TRIMM_HUMAN Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2) TRIML2 SPRYD6 Homo sapiens (Human) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; response to retinoic acid [GO:0032526] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LRHGQQDGAGNPER;QQECISDLNLR 2 5.7 0.9569 -1.026 0 7.46385 0 0 0 0 0 0 0 0 0 0 Q8N7H5 PAF1_HUMAN RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) PAF1 PD2 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] EGDGVYYNELETRVR;GQAQGGSDNDSDSGSNGGGQRSR;MWINPCAQVIFDSDPAPK;SHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD 4 17.5 0.95183 -0.69472 0 8.53282 0 0 0 4.63035 0 0 7.93887 4.33149 9.04119 0 Q8N7J2 AMER2_HUMAN APC membrane recruitment protein 2 (Amer2) (Protein FAM123A) AMER2 FAM123A Homo sapiens (Human) ectoderm development [GO:0007398]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AEPGPGEVR;EEPRGGGDSGGGGGGRPNPGPPR;TKIPVSKVLVR 3 6.4 0.96579 -1.2615 0 0 0 0 0 0 0 3.0545 0 9.42448 0 0 Q8N7K0 ZN433_HUMAN Zinc finger protein 433 ZNF433 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GYGKTFSLPSLFHRHER;IVGERLFESK;KWKPQNIYVEYENLRR;SFNCSSSFRYHGR;VFRCSSQLQVHGR 5 10.3 0.97586 -2.3106 0 0 0 0 0 0 6.96982 12.1022 0 0 10.9301 0 Q8N7L0 F216B_HUMAN Protein FAM216B FAM216B C13orf30 Homo sapiens (Human) IYNSRPQWEALQTR;RCPSVLPVSVVLPRAQSK 2 23 0.40365 0.20729 0 0 0 0 0 8.31945 0 0 0 8.1879 0 0 Q8N7M0 DYLT5_HUMAN Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1) DYNLT5 TCTEX1D1 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868] dynein intermediate chain binding [GO:0045505] DLMIPRYKLIVIVHIGQLNR;EIHGRIKDSMSTVSYMEEPSQR;LIVIVHIGQLNRQSILIGSR;MMMSDNAKGRAAHSWK 4 36.9 0.97905 -1.9638 0 11.1277 0 0 8.33584 0 0 0 0 9.32073 9.45582 0 Q8N7N1 F86B1_HUMAN Putative protein N-methyltransferase FAM86B1 (EC 2.1.1.-) FAM86B1 Homo sapiens (Human) methylation [GO:0032259]; regulation of translation [GO:0006417] protein-containing complex [GO:0032991] protein-lysine N-methyltransferase activity [GO:0016279] TLRSFPWQSLEAKLR 1 5.1 0.95387 -0.92061 11.7211 0 0 0 0 0 0 0 0 0 0 0 Q8N7P1 PLD5_HUMAN Inactive phospholipase D5 (Inactive PLD 5) (Inactive choline phosphatase 5) (Inactive phosphatidylcholine-hydrolyzing phospholipase D5) (PLDc) PLD5 Homo sapiens (Human) membrane [GO:0016020] catalytic activity [GO:0003824] ELGVIFYNCSCLVLDLQR;LEHSQQK;NHTFPRLNR;VGANFYSSVK 4 8.2 0.95445 -0.95264 0 0 10.1132 0 0 0 0 10.7226 5.25297 0 14.3745 0 Q8N7P3 CLD22_HUMAN Claudin-22 CLDN22 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] IGESQRDLK 1 4.1 0.95987 -1.0533 0 0 0 0 0 0 0 11.107 0 0 0 0 Q8N7P7 YH007_HUMAN Uncharacterized protein FLJ40521 Homo sapiens (Human) NPEDDGCLLKQEPR;NPEDDGCLLKQGPR 2 12.4 0.95539 -0.8802 0 0 11.6562 0 0 0 0 0 0 0 0 7.45426 Q8N7R7 CCYL1_HUMAN Cyclin-Y-like protein 1 CCNYL1 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; neurogenesis [GO:0022008]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein phosphorylation [GO:0001932]; spermatogenesis [GO:0007283] plasma membrane [GO:0005886] protein kinase binding [GO:0019901] LLTYAEIDICPTNWK;VPEEYFK 2 6.1 0.91087 -0.28515 0 0 0 0 0 0 9.28953 0 0 8.53391 9.26365 0 Q8N7U6 EFHB_HUMAN EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21) EFHB CFAP21 Homo sapiens (Human) calcium ion transport [GO:0006816]; flagellated sperm motility [GO:0030317]; negative regulation of protein binding [GO:0032091]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of store-operated calcium entry [GO:2001256] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891] EAGSTEKTLR;LITPPEAKK;VATCLTEK;VATCLTEKLPR 4 3.6 0.97334 -2.634 0 0 0 0 0 10.9443 0 0 10.4673 0 0 0 Q8N7W2 BEND7_HUMAN BEN domain-containing protein 7 BEND7 C10orf30 Homo sapiens (Human) extracellular exosome [GO:0070062] DNA binding [GO:0003677] LLNDSTGR;LPGPRDWVQILQDQIK 2 5.8 0.96715 -1.3018 0 0 0 0 0 0 0 0 0 9.21284 0 0 Q8N7X0 ADGB_HUMAN Androglobin ADGB C6orf103 Homo sapiens (Human) proteolysis [GO:0006508]; spermatid development [GO:0007286] sperm annulus [GO:0097227]; sperm midpiece [GO:0097225] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825] AAQGIQKSPK;DSPCNSFAIK;IFDIREEYR;TAKEKQAPR 4 2.3 0.97431 -3.5166 0 0 0 0 0 0 11.4036 0 0 0 11.0293 0 Q8N7X1 RMXL3_HUMAN "RNA-binding motif protein, X-linked-like-3" RBMXL3 CXorf55 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" mRNA binding [GO:0003729]; snRNA binding [GO:0017069] AAARDMNGK;ALKAEFGK;APTVSGQDGYSGLQPR;GFAFVTFESPADAK;SPDTHSGGHSSSSNSYGQSHRYGGEGR;YSRGRDR 6 7.6 0.97288 -2.5026 8.11353 0 0 0 0 9.12228 0 0 0 0 0 10.2032 Q8N7X8 SIGL1_HUMAN SIGLEC family-like protein 1 SIGLECL1 C19orf75 Homo sapiens (Human) membrane [GO:0016020] LPLLQLVPAK 1 5.1 0.89779 -0.23883 0 0 0 0 0 0 0 0 0 6.83175 0 0 Q8N7Y1 KIAS3_HUMAN Putative uncharacterized protein KIRREL3-AS3 (KIRREL3 antisense RNA 1) (KIRREL3 antisense gene protein 1) (Proline-rich protein 10) KIRREL3-AS3 NCRNA00288 PRR10 Homo sapiens (Human) GEERDRRPCWKPSRPGAAR 1 7.9 0.96387 -1.0942 0 0 0 0 0 0 0 0 0 11.447 0 0 Q8N7Z5 ANR31_HUMAN Ankyrin repeat domain-containing protein 31 ANKRD31 Homo sapiens (Human) homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [GO:0010780]; positive regulation of meiotic DNA double-strand break formation [GO:1903343] chromatin [GO:0000785]; nucleus [GO:0005634] ENSDNDDDDDCSTSEKAITSKK;ETSLVEPEK;GNLHNVK;IQNCRNVTSLPCLSLRK;MQDPALMIDGKEK;NDDGKCALDEAKDLCMK;QCFCDDGK;RLLFDQDASLK;SHIWHVYNENSNR;SRHSDGTEK 10 6.7 0.98044 -1.6424 0 0 0 0 7.9982 14.2748 11.5835 4.53282 6.49624 0 10.3413 10.2123 Q8N806 UBR7_HUMAN Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) UBR7 C14orf130 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LFELYTKR;RVDGMQYYCS 2 4.2 0.38502 0.21592 0 0 0 9.07393 0 0 10.9304 0 0 5.86923 0 0 Q8N807 PDILT_HUMAN Protein disulfide-isomerase-like protein of the testis PDILT Homo sapiens (Human) germ cell migration [GO:0008354]; protein folding [GO:0006457]; spermatid development [GO:0007286] endoplasmic reticulum [GO:0005783] protein disulfide isomerase activity [GO:0003756]; protein folding chaperone [GO:0044183] SFLSKNATKHQSSEEIPK;VTEVDIPSVQILNLSSDAR 2 6.3 0.97526 -1.3911 0 0 0 0 0 0 0 0 0 0 11.586 0 Q8N808 S35G3_HUMAN Solute carrier family 35 member G3 (Acyl-malonyl-condensing enzyme 1) (Transmembrane protein 21A) SLC35G3 AMAC1 TMEM21A Homo sapiens (Human) membrane [GO:0016020] CLFHLPIALLLKLR;MAYQASNLPSLELLIWR 2 9.2 0.64875 0.17041 0 0 0 0 7.65141 0 8.68184 0 0 6.42129 0 0 Q8N814 YG045_HUMAN Putative uncharacterized protein FLJ40140 Homo sapiens (Human) LPSGSEPRAR 1 7.3 0.88726 -0.18289 0 0 0 0 0 0 0 0 0 0 12.6311 0 Q8N815 CNTD1_HUMAN Cyclin N-terminal domain-containing protein 1 CNTD1 CNTD Homo sapiens (Human) reciprocal meiotic recombination [GO:0007131]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] LVSCVQLASK;QATIQPR;QATIQPRDNKR;RESQNWRALK 4 9.1 0.97601 -1.4819 0 6.49675 0 0 9.9747 0 0 0 0 0 0 0 Q8N819 PPM1N_HUMAN Probable protein phosphatase 1N (EC 3.1.3.16) PPM1N Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytosol [GO:0005829]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] DLRERAWSFGK;FLYLAHCGDSR 2 6.5 0.88299 -0.17148 0 0 0 0 9.19938 0 0 0 0 0 0 0 Q8N823 ZN611_HUMAN Zinc finger protein 611 ZNF611 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGHTGEKPYKCKVCDK;STIETHK 2 3.3 0.93657 -0.55575 8.64595 0 0 8.46655 0 0 0 7.67483 0 0 0 0 Q8N831 TSYL6_HUMAN Testis-specific Y-encoded-like protein 6 (TSPY-like protein 6) TSPYL6 Homo sapiens (Human) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] AIDEVNR;RGHGPQSFIHRNR 2 4.9 0.74637 0.096473 0 0 0 0 9.33089 0 12.7142 12.1769 0 0 0 0 Q8N841 TTLL6_HUMAN Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6) TTLL6 TTL.6 Homo sapiens (Human) microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] 9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" DAHSGSK;DFRFFPR;EDPKETVALAFVR;INHFPGMSEICRKDLLAR;LIYPSLNSEKYEK;QQTPPHLTQKK 6 7.7 0.97512 -3.6117 6.81224 11.7578 7.5397 0 0 5.3695 0 0 11.4818 0 0 9.89806 Q8N859 ZN713_HUMAN Zinc finger protein 713 ZNF713 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AFSQRTHLNQHER;AFSQSAHLNQHRK;KITQERSLECNK 3 8.6 0.95881 -1.0399 0 0 0 0 0 0 6.74228 12.3088 0 0 0 8.15284 Q8N865 SMIP4_HUMAN Sperm-associated microtubule inner protein 4 SPMIP4 C7orf31 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] GAMFPTFTSPEDLYTGIK;MVAELTR;VLCNFHTFVPSSK 3 6.4 0.93022 -0.46939 3.71061 0 0 0 3.33285 0 11.917 0 0 0 0 0 Q8N878 FRMD1_HUMAN FERM domain-containing protein 1 FRMD1 Homo sapiens (Human) positive regulation of hippo signaling [GO:0035332] cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856] DVLVLLPSREQLRLAVGVK;EPSSSPRTSR;ESAHAGR 3 6.6 0.97764 -1.5001 0 0 0 0 0 0 0 6.85437 0 0 0 0 Q8N883 ZN614_HUMAN Zinc finger protein 614 ZNF614 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HLKTNTTDK;LSRSVLFTKHLK;NCPGIGK;THTGERPYGCSDCEKAFSHLSNLVK;TLIIHQR 5 9.7 0.9807 -2.0215 0 0 10.5606 8.13217 0 0 0 0 0 7.8586 0 0 Q8N884 CGAS_HUMAN Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) CGAS C6orf150 MB21D1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cAMP-mediated signaling [GO:0019933]; cellular response to exogenous dsRNA [GO:0071360]; cGAS/STING signaling pathway [GO:0140896]; cGMP-mediated signaling [GO:0019934]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; paracrine signaling [GO:0038001]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cellular senescence [GO:2000774]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of immunoglobulin production [GO:0002637]; regulation of T cell activation [GO:0050863] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861] "2',3'-cyclic GMP-AMP synthase activity [GO:0061501]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nucleosome binding [GO:0031491]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; protein homodimerization activity [GO:0042803]" DTDVIMK;IQLEEYSNTRAYYFVKFK;IQNWLSAKVRK 3 6.9 0.98092 -1.689 3.49608 13.5409 0 0 7.62578 0 0 0 13.2076 0 0 0 Q8N8A2 ANR44_HUMAN Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) RTPLHASVINGHTLCLR;STPGTAVQK;TEDVNTLDSEK;TPLHYAAAR 4 4.6 0.91074 -0.29878 0 11.6439 0 0 0 0 0 9.24377 11.2753 0 0 0 Q8N8A6 DDX51_HUMAN ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) DDX51 Homo sapiens (Human) rRNA processing [GO:0006364] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LLQPLVPR 1 1.2 0.91998 -0.43777 0 0 0 0 0 0 8.94959 0 0 0 0 0 Q8N8C0 ZN781_HUMAN Zinc finger protein 781 ZNF781 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] LLGKVHILLNIK 1 3.4 0.30445 0.24947 0 0 9.89266 0 0 0 0 0 5.88489 0 0 5.55149 Q8N8D1 PDCD7_HUMAN Programmed cell death protein 7 (ES18) (hES18) PDCD7 Homo sapiens (Human) apoptotic process [GO:0006915]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] GVCPPASADETFTHHLQR;HDWDQYLVPSDHPK 2 6.6 0.54871 0.18425 0 0 0 7.15391 0 0 0 6.30584 0 0 0 0 Q8N8D7 NKAI3_HUMAN Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3) (Protein FAM77D) NKAIN3 FAM77D Homo sapiens (Human) regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] HLFIQMLQIIE;MGCCTGR 2 9.1 0.95407 -0.90506 0 0 0 0 0 0 7.06134 0 0 0 0 5.85412 Q8N8E2 ZN513_HUMAN Zinc finger protein 513 ZNF513 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] CARCPYASAHLDNLKR 1 3 0.84928 -0.070911 10.3144 0 0 0 0 0 0 0 0 0 0 0 Q8N8E3 CE112_HUMAN Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) receptor localization to synapse [GO:0097120] centrosome [GO:0005813]; cytoplasm [GO:0005737]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886] DHEREIENLEK;DSLVRDHER;EFLWQLEDIRQR;LCEPSGTGAGIMGR;LIQEKAELERCYQITCSELQEVK;LQAQQADAALEEFKRQVELNSEK;QQLQESELQR;SHSLSPTHREDGQNITPK;VLQDELENR 9 13.1 0.97533 -3.3551 0 0 0 0 0 8.46197 8.71352 0 8.05403 9.0773 12.7433 0 Q8N8I0 SAM12_HUMAN Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12) SAMD12 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] cytoplasmic side of plasma membrane [GO:0009898] QHILQQVLQLKVREEVR 1 8.5 0.53291 0.1866 0 0 0 0 0 0 0 0 0 3.95336 0 4.87863 Q8N8I6 CQ055_HUMAN Putative uncharacterized protein encoded by LINC00482 LINC00482 C17orf55 Homo sapiens (Human) AAAWWGRLEGAKASAK 1 6.1 0.2548 0.2719 0 0 0 0 0 0 0 8.77386 0 0 0 0 Q8N8J6 ZN615_HUMAN Zinc finger protein 615 ZNF615 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DGKSLFHANHK 1 1.5 0.88817 -0.18347 0 0 0 8.0433 0 0 0 0 0 0 0 0 Q8N8K9 K1958_HUMAN Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) EDCLHTSSENLSK;GIVPNLAKK;YWCMTNGLKDHTDITK 3 5.3 0.91764 -0.40916 0 0 0 3.93782 0 0 0 0 0 7.46736 0 0 Q8N8K9 K1958_HUMAN Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) EDCLHTSSENLSK;EIYVIPCK;ELDAYLASFFVDAR;RGGTDSR;SQEALKQKQIELR 5 7.5 0.97885 -1.9663 0 0 0 0 0 0 0 0 0 0 10.1233 10.5002 Q8N8L2 ZN491_HUMAN Zinc finger protein 491 ZNF491 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ALDCLSLYLTHER;ALSHSHCFR 2 5 0.84117 -0.049156 0 0 0 0 0 6.23766 13.2163 0 0 0 0 0 Q8N8M0 NAT16_HUMAN Probable N-acetyltransferase 16 (EC 2.3.1.-) NAT16 C7orf52 Homo sapiens (Human) "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" GVAGLLQR;YRLITKQGILLVR 2 5.7 0.97921 -2.0467 0 0 0 8.2094 8.02525 0 0 0 0 0 0 0 Q8N8P6 YX004_HUMAN Putative uncharacterized protein FLJ39060 Homo sapiens (Human) AKHIEPTLRPVPLKELR 1 13.8 0.53407 0.18652 0 0 0 0 0 0 10.3505 10.408 9.83986 0 0 0 Q8N8Q3 ENDOV_HUMAN Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease) ENDOV Homo sapiens (Human) DNA repair [GO:0006281] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730] "DNA binding [GO:0003677]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; single-stranded RNA binding [GO:0003727]" LTCCCCR;SLGLPGPPTPRSPK 2 7.4 0.95298 -0.76342 0 0 9.71495 0 0 0 7.44642 7.43563 8.62564 0 0 6.72315 Q8N8Q8 COX18_HUMAN "Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18Hs) (Cytochrome c oxidase assembly protein 18)" COX18 OXA1L2 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]; respiratory chain complex IV assembly [GO:0008535] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] membrane insertase activity [GO:0032977] DARLTYLK;LTYLKNMRR 2 3.6 0.98002 -1.5703 0 0 0 0 0 5.44135 0 0 0 0 0 6.63458 Q8N8Q9 NIPA2_HUMAN Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2) NIPA2 Homo sapiens (Human) magnesium ion transport [GO:0015693] early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095] DVSFSLASLPVSFR 1 3.9 0.78321 0.024225 0 0 0 0 0 9.93626 0 0 0 0 0 10.2508 Q8N8R7 AL14E_HUMAN ARL14 effector protein (ARF7 effector protein) ARL14EP ARF7EP C11orf46 Homo sapiens (Human) cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] SLQFTNPGR 1 3.5 0.78158 0.021798 0 0 12.7695 0 0 0 0 0 0 0 0 0 Q8N8S7 ENAH_HUMAN Protein enabled homolog ENAH MENA Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; actin polymerization-dependent cell motility [GO:0070358]; axon guidance [GO:0007411]; postsynaptic cytoskeleton organization [GO:0099188] cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; WW domain binding [GO:0050699] ASSTSTPEPTR;QLQEQQR 2 3 0.96486 -1.1547 0 0 0 0 0 0 0 8.5247 0 0 0 0 Q8N8U2 CDYL2_HUMAN Chromodomain Y-like protein 2 (CDY-like 2) CDYL2 Homo sapiens (Human) nucleus [GO:0005634] methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] EEGFTHILLSSQTSDNNALTPEIMKEVR;LLLLSAVGSVFCSGLDYSYLIGRLSSDR;WEYLIRWK 3 12.6 0.9803 -1.7129 0 0 0 0 10.7436 0 0 0 10.9339 6.49467 0 0 Q8N8V2 GBP7_HUMAN Guanylate-binding protein 7 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like) GBP7 GBP4L Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; negative regulation of cytokine production [GO:0001818]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type I interferon production [GO:0032480]; negative regulation of type III interferon production [GO:0034345]; positive regulation of viral genome replication [GO:0045070]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EQELLRQK;YCQAELK;YCQAELKR 3 2.5 0.95835 -1.0036 0 0 0 0 0 0 9.02503 0 0 0 0 0 Q8N8V4 ANS4B_HUMAN Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) ANKS4B HARP Homo sapiens (Human) brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; response to endoplasmic reticulum stress [GO:0034976] brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; plasma membrane [GO:0005886] ECERLQEKHQNK 1 2.9 0.86808 -0.093407 0 0 0 5.75093 0 0 0 0 0 0 0 0 Q8N8W4 PLPL1_HUMAN Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1) PNPLA1 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; omega-hydroxyceramide biosynthetic process [GO:0106342]; triglyceride catabolic process [GO:0019433] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; omega-hydroxyceramide transacylase activity [GO:0106341]; structural constituent of skin epidermis [GO:0030280]; triacylglycerol lipase activity [GO:0004806]" VLNVGVAEVKKSFLGPLSPSCK 1 4.1 0.54777 0.18352 8.80983 0 0 0 0 0 0 0 0 0 0 0 Q8N8X9 MB213_HUMAN Protein mab-21-like 3 MAB21L3 C1orf161 Homo sapiens (Human) VLLVFRKLVENAVR 1 3.9 0.87055 -0.091045 3.54275 0 0 0 0 0 0 0 0 0 0 0 Q8N8Z6 DCBD1_HUMAN "Discoidin, CUB and LCCL domain-containing protein 1" DCBLD1 Homo sapiens (Human) plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] AAGRGLLALLLAVSAPLR;DVAGDISGNMVDGYR;LDLITSDMAG;YPFARHQSAEFTISYDNEK 4 11.5 0.97797 -2.0631 0 0 7.01903 0 0 0 0 0 0 7.10287 0 0 Q8N8Z8 ZN441_HUMAN Zinc finger protein 441 ZNF441 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFICCTYLQIHER;IWQNHDIEEDQYK;QCGKAFICCTYLQIHERIHTGERPYK 3 6 0.17373 0.34128 0 0 0 8.83772 0 5.27732 0 0 0 0 9.09714 0 Q8N944 AMER3_HUMAN APC membrane recruitment protein 3 (Amer3) (Protein FAM123C) AMER3 FAM123C Homo sapiens (Human) regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" KCFRNLFHIR 1 1.2 0.95869 -1.0066 0 0 0 0 0 0 0 0 0 9.05918 0 0 Q8N954 GPT11_HUMAN G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) GPATCH11 CCDC75 CENP-Y Homo sapiens (Human) kinetochore [GO:0000776] nucleic acid binding [GO:0003676] AEEKLESYR;GEQRAVRYYSHMK 2 7.7 0.91712 -0.35544 0 10.6962 0 0 0 0 0 10.3979 0 0 0 0 Q8N957 ANKF1_HUMAN Ankyrin repeat and fibronectin type-III domain-containing protein 1 ANKFN1 Homo sapiens (Human) behavioral fear response [GO:0001662]; equilibrioception [GO:0050957]; establishment of mitotic spindle orientation [GO:0000132]; locomotor rhythm [GO:0045475]; regulation of establishment of bipolar cell polarity [GO:0061172] spindle [GO:0005819] AGPALDDPR;EKQLKAWEWR;QLKAWEWRYR;QRHQQVLDFIQQIDEVWR;VYYEPIKDRHGNILIVTIR 5 5.1 0.97369 -2.6476 0 11.9043 0 9.91903 0 10.1152 7.22882 0 0 9.62593 0 0 Q8N960 CE120_HUMAN Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) CEP120 CCDC100 Homo sapiens (Human) astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; neurogenesis [GO:0022008]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] IADLSYTVTLEDYGLVK;IRSSVEILRVYLALQSK;LQKTLIDLEKR;MLVVEAK;QELLDIRNELNRLR;SIHALEIGFPINCILR 6 8.5 0.97839 -2.1268 0 12.0059 0 0 0 0 10.9683 0 0 5.13697 11.2226 0 Q8N961 ABTB2_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 Homo sapiens (Human) cellular response to toxic substance [GO:0097237] protein heterodimerization activity [GO:0046982] CPRLPELEEFPWTEGDVAR;HPLCPGASPARQAR;KGAGGRR;LAGLLRRALIR;VAITYAEHR 5 5.9 0.96424 -1.1786 0 9.839 0 0 0 0 0 0 10.2105 10.0414 3.95345 0 Q8N967 LRTM2_HUMAN Leucine-rich repeat and transmembrane domain-containing protein 2 LRTM2 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; positive regulation of synapse assembly [GO:0051965] membrane [GO:0016020] heparin binding [GO:0008201]; Roundabout binding [GO:0048495] LAPGSSPGQR;LDLSNNFLDRLPR;SLSLRSNRLQNLDR;TLDRDLLR;TLLLLNNK 5 14.3 0.97301 -2.9527 0 0 0 0 0 0 11.2741 12.7231 9.46936 0 0 0 Q8N972 ZN709_HUMAN Zinc finger protein 709 ZNF709 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QCGKAFSFSSSFR 1 2 0.92406 -0.4481 0 0 0 0 0 6.39743 0 0 0 0 0 0 Q8N983 RM43_HUMAN "Large ribosomal subunit protein mL43 (39S ribosomal protein L43, mitochondrial) (L43mt) (MRP-L43) (Mitochondrial ribosomal protein bMRP36a)" MRPL43 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LARPNISSVIRSSLGK;YVQQLQR 2 9.8 0.88156 -0.15765 0 0 0 0 0 8.3773 0 0 0 0 0 0 Q8N987 NECA1_HUMAN N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Neuronal calcium-binding protein 1) NECAB1 EFCBP1 Homo sapiens (Human) blastocyst hatching [GO:0001835]; regulation of amyloid precursor protein biosynthetic process [GO:0042984] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] LSFEEFK 1 2 0.90852 -0.31326 0 0 0 0 0 0 0 0 10.2993 0 0 0 Q8N988 ZN557_HUMAN Zinc finger protein 557 ZNF557 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SYLAVHKRIHNGEKPYECNDCGK 1 5.4 0.58969 0.17852 0 0 0 0 5.27131 0 6.74672 0 0 0 0 0 Q8N998 CCD89_HUMAN Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein) CCDC89 BOIP Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] LEIANEDRK;LEKQNEK;MRAPMLQKQQAPR 3 7.8 0.98108 -1.7301 0 0 11.1773 0 0 0 0 0 10.2602 0 10.3211 0 Q8N999 RLIG1_HUMAN RNA ligase 1 (EC 6.5.1.3) (RNA ligase) (Rnl) RLIG1 C12orf29 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; response to reactive oxygen species [GO:0000302]; RNA repair [GO:0042245] ATP binding [GO:0005524]; RNA ligase (ATP) activity [GO:0003972] LDRKPNKQAEK;MPCVFVTEVKEEPSSKR 2 8.6 0.74605 0.096401 0 0 6.98048 0 0 0 0 0 0 6.44731 0 0 Q8N9A8 NEPR1_HUMAN Nuclear envelope phosphatase-regulatory subunit 1 (NEP1-R1) (Transmembrane protein 188) CNEP1R1 C16orf69 TMEM188 Homo sapiens (Human) lipid metabolic process [GO:0006629]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] protein phosphatase regulator activity [GO:0019888] LTEYIHCLQPATGR 1 9.9 0.78898 0.017107 0 0 0 5.53512 0 0 0 0 0 0 0 0 Q8N9B4 ANR42_HUMAN Ankyrin repeat domain-containing protein 42 ANKRD42 Homo sapiens (Human) nucleus [GO:0005634] NF-kappaB binding [GO:0051059] RPSKNCRASWSMNDYVEK;VHFGSIHDAVR;YFIRHGVEGSTDAK 3 11.1 0.97944 -1.8538 0 0 0 0 0 0 9.8445 0 0 9.24091 0 0 Q8N9B5 JMY_HUMAN Junction-mediating and -regulatory protein JMY Homo sapiens (Human) 'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to starvation [GO:0009267]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase II [GO:0006357] autophagosome membrane [GO:0000421]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; transcription coactivator activity [GO:0003713] EICIAKHNEKIQQR;EICLEQRK;IESLQKEDADWQR;LQQKARQLEAR;TLDRLRTFK 5 5.6 0.97335 -2.8839 0 0 0 0 0 0 0 9.88203 10.4727 0 0 10.3582 Q8N9C0 IGS22_HUMAN Immunoglobulin superfamily member 22 (IgSF22) IGSF22 Homo sapiens (Human) FVSNLKNVR;VEFLELSGSCVHMKWK 2 1.9 0.95872 -1.0399 0 0 0 0 0 0 0 0 0 0 0 10.7267 Q8N9E0 F133A_HUMAN Protein FAM133A FAM133A Homo sapiens (Human) SCRSSSSSSSSDSSSSSSDSEDEEK;SSSSSSSSDSSSSSSDSEDEEK 2 10.1 0.72753 0.12629 0 0 0 0 0 0 10.3059 0 6.46223 0 0 0 Q8N9F0 NAT8L_HUMAN N-acetylaspartate synthetase (NAA synthetase) (EC 2.3.1.17) (Camello-like protein 3) (N-acetyltransferase 8-like protein) NAT8L CML3 Homo sapiens (Human) aspartate family amino acid metabolic process [GO:0009066] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] aspartate N-acetyltransferase activity [GO:0017188] MHCGPPDMVCETK 1 4.3 0.89767 -0.23974 0 0 7.24916 0 0 7.79714 0 0 0 7.97522 0 0 Q8N9F8 ZN454_HUMAN Zinc finger protein 454 ZNF454 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ICEKAFIRSTHLTQHQR 1 3.3 0.48709 0.18977 0 0 0 0 6.84386 0 0 0 0 0 0 0 Q8N9H8 MUT7_HUMAN Exonuclease mut-7 homolog (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3) EXD3 HBE269 Homo sapiens (Human) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] CFYCCTGCGK;MSIPLLLQDKVALVER;QLREEAWR 3 3.9 0.97996 -1.8203 0 0 10.7641 5.50249 0 0 11.193 0 0 0 0 0 Q8N9H9 CA127_HUMAN Uncharacterized protein C1orf127 C1orf127 Homo sapiens (Human) QTPWLLSLR 1 1.4 0.93367 -0.50018 0 0 0 0 0 0 0 0 0 8.28531 0 0 Q8N9I5 FADS6_HUMAN Fatty acid desaturase 6 (EC 1.14.19.-) FADS6 FP18279 Homo sapiens (Human) fatty acid biosynthetic process [GO:0006633]; lipid metabolic process [GO:0006629] membrane [GO:0016020] "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" EPARSAHR;QLPYNEDSYLARFQLFLR 2 7.7 0.98098 -1.784 0 0 0 0 0 5.9638 0 0 0 0 0 0 Q8N9K5 ZN565_HUMAN Zinc finger protein 565 ZNF565 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSRSSYLIQHQR;GPWERWSLASHR 2 4.6 0.93032 -0.47668 0 0 0 0 8.46128 7.94398 0 0 0 0 0 0 Q8N9L9 ACOT4_HUMAN Peroxisomal succinyl-coenzyme A thioesterase (EC 3.1.2.3) (Acyl-coenzyme A thioesterase 4) (Acyl-CoA thioesterase 4) (EC 3.1.2.2) (PTE-2b) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-CoA thioesterase Ib) (PTE-Ib) ACOT4 PTE2B PTEIB Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; dicarboxylic acid catabolic process [GO:0043649]; dicarboxylic acid metabolic process [GO:0043648]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; saturated monocarboxylic acid metabolic process [GO:0032788]; short-chain fatty acid metabolic process [GO:0046459]; succinyl-CoA metabolic process [GO:0006104]; unsaturated monocarboxylic acid metabolic process [GO:0032789]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617]; succinyl-CoA hydrolase activity [GO:0004778] GALFRAHARYCADAR 1 3.6 0.75885 0.071429 0 0 0 0 0 0 0 0 9.97785 0 0 0 Q8N9M5 TM102_HUMAN Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) TMEM102 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of cell adhesion [GO:0045785]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; response to cytokine [GO:0034097]; signal transduction [GO:0007165] cell surface [GO:0009986]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] VLEAGTLPHYFLNGR 1 3 0.89315 -0.22181 0 0 0 0 0 0 9.71418 0 0 0 0 0 Q8N9N2 ASCC1_HUMAN Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) ASCC1 CGI-18 Homo sapiens (Human) DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355] DNA repair complex [GO:1990391]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] RNA binding [GO:0003723] APSLLYKHIVGK;DPNAEGR;ESFDGRNILK;EVLRPQLIR 4 10.6 0.97312 -2.4982 0 0 0 0 7.25143 0 0 0 0 13.3066 6.31404 0 Q8N9N5 BANP_HUMAN Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) BANP BEND1 SMAR1 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802] FGITESDWYRIK;LQALEATCK;QNAIVAK 3 5.4 0.97462 -1.381 0 0 0 0 0 7.09381 0 0 0 0 0 0 Q8N9N7 LRC57_HUMAN Leucine-rich repeat-containing protein 57 LRRC57 Homo sapiens (Human) extracellular exosome [GO:0070062]; membrane [GO:0016020] IESLPPLLIGKFTLLKSLSLNNNK;TGVFQLKDR 2 13.8 0.94495 -0.64526 0 5.37653 0 0 0 0 0 0 0 0 0 0 Q8N9N8 EIF1A_HUMAN Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin) EIF1AD Homo sapiens (Human) cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] AEISFVLCK;AEISFVLCKDHVR 2 7.9 0.95558 -0.87508 0 0 0 0 0 0 7.59694 7.01022 0 0 0 0 Q8N9P0 YF006_HUMAN Putative uncharacterized protein FLJ36797 Homo sapiens (Human) GAPPAWGQAPSPR 1 5.6 0.93637 -0.5181 0 0 0 0 0 0 0 0 11.3287 0 0 0 Q8N9P6 CI163_HUMAN Uncharacterized protein C9orf163 C9orf163 Homo sapiens (Human) FLTCLNR;LVREGVISVPRQQGR 2 10.8 0.91846 -0.43603 0 0 0 0 0 0 0 0 0 0 0 9.62766 Q8N9Q2 SR1IP_HUMAN Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) SREK1IP1 P18SRP SFRS12IP1 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AVPGCNK 1 4.5 0.90925 -0.31232 0 0 7.13072 0 0 0 0 0 0 0 0 0 Q8N9R6 CDRT4_HUMAN CMT1A duplicated region transcript 4 protein CDRT4 Homo sapiens (Human) SSKSSGK 1 4.6 0.71147 0.1567 0 0 0 9.57493 8.92032 0 9.77449 0 0 0 9.85524 0 Q8N9R8 SCAI_HUMAN Protein SCAI (Suppressor of cancer cell invasion protein) SCAI C9orf126 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714] DIINGDAIHK;DLPQYGQK;FIFCSATMR;GSGDSSHSQSQGER 4 6.5 0.9725 -1.3616 0 0 0 8.21607 0 0 0 0 10.1051 0 4.63238 10.2666 Q8N9S9 SNX31_HUMAN Sorting nexin-31 SNX31 Homo sapiens (Human) endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886] early endosome [GO:0005769]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] ELLGYFGLFLIR;RDQLEQYLQNVTMDPNVLR;VFGNCLPPFPPK 3 9.8 0.76935 0.056809 0 0 0 0 0 0 12.6263 10.1669 0 0 0 0 Q8N9T2 CX042_HUMAN Putative uncharacterized protein CXorf42 (NF-kappa-B-activating protein pseudogene 1) NKAPP1 CXorf42 Homo sapiens (Human) FCLLLRLLRQLLTLLR 1 12.8 0.47838 0.19052 0 0 0 5.28854 5.1254 0 0 0 6.71246 0 0 0 Q8N9T8 KRI1_HUMAN Protein KRI1 homolog KRI1 Homo sapiens (Human) "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730] RNA binding [GO:0003723] EAPLTGK;ELNRWCSLK;KQEELKQLK;LDYEDIIDDLPCRFKYR;YGDRDSSSDSSSESDSSDER 5 8.8 0.97914 -1.9712 0 0 9.61668 0 7.30031 11.1692 0 0 0 12.8631 13.0064 7.89184 Q8N9U0 TAC2N_HUMAN Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) TC2N C14orf47 MTAC2D1 Homo sapiens (Human) nucleus [GO:0005634] IQTQTPR;LQNLQTVRLVFK;LVFKIQTQTPRK;MATEFIK 4 5.5 0.97843 -2.0865 0 0 0 0 0 0 0 0 0 8.97117 7.99532 0 Q8N9V2 TRIML_HUMAN Probable E3 ubiquitin-protein ligase TRIML1 (EC 2.3.2.27) (RING finger protein 209) (RING-type E3 ubiquitin transferase TRIML1) (Tripartite motif family-like protein 1) TRIML1 RNF209 Homo sapiens (Human) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EEEQLQLQLLEQEEK;LCQEETK;LQEILNLLR 3 6.6 0.98054 -1.6485 0 0 0 0 0 0 0 0 0 8.93112 0 0 Q8N9V3 WSDU1_HUMAN "WD repeat, SAM and U-box domain-containing protein 1" WDSUB1 WDSAM1 Homo sapiens (Human) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] LASCGQDCQVK 1 2.3 0.88169 -0.1581 0 0 10.3034 0 0 0 0 0 0 0 0 0 Q8N9V7 TOPZ1_HUMAN Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) TOPAZ1 C3orf77 Homo sapiens (Human) apoptotic process [GO:0006915]; ectopic germ cell programmed cell death [GO:0035234]; lncRNA transcription [GO:0140742]; spermatocyte division [GO:0048137] cytosol [GO:0005829] AVNIFMEYYR;DPQNSKVDK;EAELPLQTER;GLIGPEK;ISAWCWKK;LWLKARAHYK;SLGLMIPYK 7 3.7 0.97495 -2.3699 0 0 11.9094 10.1024 0 9.35149 0 0 11.5183 0 0 0 Q8N9W4 GG6L2_HUMAN Golgin subfamily A member 6-like protein 2 GOLGA6L2 Homo sapiens (Human) EGGEDTR;EKLWEQEK;EQEEKMRR;KADRYIEELTK;MWEQEEK 5 5.3 0.96559 -1.1462 0 0 0 0 0 0 0 7.32625 6.75662 0 0 0 Q8N9W5 DAAF3_HUMAN Dynein axonemal assembly factor 3 DNAAF3 C19orf51 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; motile cilium assembly [GO:0044458] dynein axonemal particle [GO:0120293] GERVAAR;GVSDWDLR;GVSDWDLRMK;QEQLQGFNTRVR 4 5.4 0.97611 -1.45 8.15168 0 0 0 6.03923 0 0 0 9.9261 0 0 10.5173 Q8N9W6 BOLL_HUMAN Protein boule-like BOLL BOULE Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494] QQVGIPR 1 2.5 0.61329 0.17449 0 0 0 0 0 0 0 0 0 0 0 7.56773 Q8N9W6 BOLL_HUMAN Protein boule-like BOLL BOULE Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494] TELEYPK 1 4 0.91651 -0.35087 0 0 0 0 0 0 0 0 0 0 9.50052 0 Q8N9Z0 ZN610_HUMAN Zinc finger protein 610 ZNF610 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KAKESGMALPQGR;YRNDLIDFPLLPQEEK 2 6.3 0.97957 -1.8511 0 0 0 10.3336 0 0 0 0 0 0 0 0 Q8N9Z2 CC71L_HUMAN Coiled-coil domain-containing protein 71L CCDC71L C7orf74 Homo sapiens (Human) ALGDAFK;SLAAARR 2 6 0.7552 0.074863 0 0 0 11.2373 0 0 10.68 10.5438 10.1266 11.8568 11.9015 0 Q8N9Z9 LMTD1_HUMAN Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1) LMNTD1 IFLTD1 Homo sapiens (Human) cell population proliferation [GO:0008283] cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear envelope [GO:0005635] DISNYQVEQAQVLLKREK;LDRQPRTR;VTISTTGQLTSK 3 9.8 0.96311 -1.0855 10.2469 0 0 0 6.60146 0 0 0 9.31899 0 0 0 Q8NA03 FSIP1_HUMAN Fibrous sheath-interacting protein 1 FSIP1 HSD10 Homo sapiens (Human) DAAEECK;LKELDSQLQDAIQKMK;LLNESETK;LSSERKK 4 6.5 0.98051 -1.795 0 13.0473 0 0 0 0 0 0 0 10.567 7.20163 12.9311 Q8NA19 LMBL4_HUMAN Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4) L3MBTL4 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] LPHGFLPNMK;VMKIKLGPALK 2 3.4 0.97683 -2.2162 10.5856 0 0 0 0 0 0 0 0 0 0 0 Q8NA31 TERB1_HUMAN Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79) TERB1 CCDC79 Homo sapiens (Human) double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141] "chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; shelterin complex [GO:0070187]" ENNLEEHWRK;HPTCAAS;SLICNKKILLTPR 3 4.1 0.98127 -1.703 11.4527 0 0 0 0 5.44688 7.01558 0 0 4.711 0 0 Q8NA47 CCD63_HUMAN Coiled-coil domain-containing protein 63 CCDC63 Homo sapiens (Human) cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; spermatid development [GO:0007286] axoneme [GO:0005930] ILVQLGETGK;NEFEEQAK;QIHILETR;VTDINLPQYFAIIEKK 4 7.5 0.97467 -1.3875 0 0 12.3193 0 0 0 0 9.52576 9.54626 7.07724 0 0 Q8NA54 IQUB_HUMAN IQ motif and ubiquitin-like domain-containing protein IQUB Homo sapiens (Human) cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]; smoothened signaling pathway [GO:0007224] 9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126] EKEEWIK;EVDLMMR;LEWETQQELRK 3 3.2 0.98013 -1.8294 9.13042 0 0 0 0 10.3573 0 0 0 0 0 0 Q8NA57 CL050_HUMAN Uncharacterized protein C12orf50 C12orf50 Homo sapiens (Human) poly(A)+ mRNA export from nucleus [GO:0016973] KPHFKGVK;LSQYERQGEIKTSLHGKPK;SEKIYPEPR;SEKIYPEPRR 4 8.9 0.97611 -1.4755 0 0 11.3773 10.7158 0 0 0 0 0 5.52218 0 0 Q8NA58 PNDC1_HUMAN Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1) PNLDC1 Homo sapiens (Human) "blastocyst formation [GO:0001825]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA processing [GO:0034587]; priRNA 3'-end processing [GO:1990431]; siRNA 3'-end processing [GO:1990432]; spermatogenesis [GO:0007283]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723] DIWKEMNFPR 1 1.9 0.91643 -0.42545 0 0 0 0 0 0 0 0 0 0 0 8.26266 Q8NA61 CBY2_HUMAN Protein chibby homolog 2 (Spermatid-associated protein) CBY2 SPERT Homo sapiens (Human) cytoplasmic vesicle [GO:0031410] identical protein binding [GO:0042802] ENKILQVFWEEHK;SLREENK 2 4.5 0.97495 -3.141 0 0 0 0 0 0 0 0 9.06848 11.3013 10.8363 0 Q8NA66 CNBD1_HUMAN Cyclic nucleotide-binding domain-containing protein 1 CNBD1 Homo sapiens (Human) LPIHRTPYEHK;LPIHRTPYEHKTVWK 2 3.4 0.95367 -0.77674 0 0 0 0 0 0 0 0 5.49105 9.05918 0 0 Q8NA70 FA47B_HUMAN Protein FAM47B FAM47B Homo sapiens (Human) LEDARAR;YHFWESCPRPFESRMPHLR 2 4 0.92203 -0.44334 0 0 0 8.83662 10.1606 0 0 0 0 0 0 0 Q8NA72 POC5_HUMAN Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) POC5 C5orf37 Homo sapiens (Human) eye photoreceptor cell development [GO:0042462] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391] AEIQRMQHEK;SVVQKQWK;TLLKKVWK 3 4.5 0.97214 -2.8021 0 4.37886 0 0 0 0 0 0 0 0 0 0 Q8NA82 MARHA_HUMAN Probable E3 ubiquitin-protein ligase MARCHF10 (EC 2.3.2.27) (Membrane-associated RING finger protein 10) (Membrane-associated RING-CH protein X) (MARCH-X) (RING finger protein 190) (RING-type E3 ubiquitin transferase MARCHF10) MARCHF10 MARCH10 RNF190 Homo sapiens (Human) protein ubiquitination [GO:0016567] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] ADPEKLK;ESATEKDR;KSPLSWDTK;LSQDPGLPDRESATEK;MAASGFTDEKETSKIK;MLHDARDRQK 6 7.4 0.97522 -3.9669 0 0 0 0 6.03221 6.39199 0 2.75125 15.1049 0 0 9.81367 Q8NA97 FEAS1_HUMAN Putative uncharacterized protein FER1L6-AS1 (FER1L6 antisense RNA 1) (FER1L6 antisense gene protein 1) FER1L6-AS1 C8orf54 Homo sapiens (Human) LFIYSSK 1 5.1 0.91283 -0.32188 0 7.64918 0 0 0 0 0 0 0 0 0 0 Q8NAA4 A16L2_HUMAN Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) ATG16L2 WDR80 Homo sapiens (Human) autophagosome assembly [GO:0000045]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; protein transport [GO:0015031] Atg12-Atg5-Atg16 complex [GO:0034274]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site membrane [GO:0034045] EAALRRLQEEAR;IRFWDSR;LTRHQAVTGSRDR 3 5.2 0.97509 -4.1511 0 0 0 10.5548 8.40352 0 0 0 10.2595 0 0 0 Q8NAB2 KBTB3_HUMAN Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3) KBTBD3 BKLHD3 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LFVIGGK;MELAMDNSYAFNQR;QKYLPHLIEKVR 3 5.4 0.91575 -0.4315 0 0 0 0 0 0 0 0 6.65578 2.95548 8.71795 0 Q8NAC3 I17RC_HUMAN Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14) IL17RC UNQ6118/PRO20040/PRO38901 Homo sapiens (Human) defense response to fungus [GO:0050832]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755] cell surface [GO:0009986]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102] SGRLQERAEQVSR 1 1.6 0.71366 0.1511 0 0 11.2871 0 0 0 0 12.1384 0 0 0 0 Q8NAF0 ZN579_HUMAN Zinc finger protein 579 ZNF579 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]" GLGGLAS;LASYLRQHR;LVHSTDRPFVCPDCGLAFRLASYLR;QEEKQVLLQADWTLLCLRCR 4 9.8 0.95511 -0.7939 0 13.0495 13.3292 0 8.96376 0 0 10.1998 0 0 12.447 0 Q8NAM6 ZSCA4_HUMAN Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494) ZSCAN4 ZNF494 Homo sapiens (Human) negative regulation of mitotic recombination [GO:0045950]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SYKCEECPK 1 2.1 0.98034 -1.5965 0 0 6.0369 0 0 0 0 0 0 0 0 0 Q8NAN2 MIGA1_HUMAN Mitoguardin 1 (Protein FAM73A) MIGA1 FAM73A Homo sapiens (Human) mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] ILPWEPEHLILEYTK 1 2.4 0.91676 -0.34244 0 0 0 8.70639 0 0 0 0 0 0 0 0 Q8NAP3 ZBT38_HUMAN Zinc finger and BTB domain-containing protein 38 ZBTB38 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355] blood microparticle [GO:0072562]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SPQPAAVLTRSKSPNNEGDVHFSR;TRHEIWHTGERR;YHCQFCFQR 3 3.8 0.88101 -0.16849 0 10.3591 0 0 0 0 0 0 0 6.26711 0 0 Q8NAP8 ZBT8B_HUMAN Zinc finger and BTB domain-containing protein 8B ZBTB8B Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CPFCPYTAKQK;HIRSHTGERPYPCETCGK 2 5.9 0.96828 -1.3242 10.7606 0 0 0 0 0 0 0 0 10.6426 0 0 Q8NAT1 PMGT2_HUMAN "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" POMGNT2 AGO61 C3orf39 EOGTL GTDC2 Homo sapiens (Human) neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363] ILQSREVPRHLCCR;YLKVREVK 2 3.8 0.98076 -1.5941 0 0 0 0 0 0 8.54581 0 0 0 9.03496 0 Q8NAT2 TDRD5_HUMAN Tudor domain-containing protein 5 TDRD5 TUDOR3 Homo sapiens (Human) P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] chromatoid body [GO:0033391]; P granule [GO:0043186]; pi-body [GO:0071546]; synapse [GO:0045202] AGSLLMLKK;AILQFQK;DSEFESLKTCNK;DSEFESLKTCNKSFEEDPK;QIMSMEKTSK 5 4.3 0.97335 -2.4866 0 0 10.413 12.562 12.5117 0 0 0 9.20706 9.68352 0 12.8147 Q8NAV1 PR38A_HUMAN Pre-mRNA-splicing factor 38A PRPF38A Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] MDDVESSEEEEEEDEK;RRSPSPR;VPSPDHR 3 24 0.87894 -0.14357 0 0 0 8.61739 0 0 0 7.05517 0 0 0 0 Q8NAV2 CH058_HUMAN Uncharacterized protein C8orf58 C8orf58 Homo sapiens (Human) DLPERPQCRPHRK;IESRDLPERPQCRPHR 2 4.7 0.90193 -0.26157 0 0 8.34256 0 0 0 0 0 0 6.42472 7.01692 0 Q8NAX2 KDF1_HUMAN Keratinocyte differentiation factor 1 KDF1 C1orf172 Homo sapiens (Human) developmental growth [GO:0048589]; establishment of skin barrier [GO:0061436]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; limb epidermis development [GO:0060887]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of epidermal cell division [GO:0010482]; stem cell proliferation [GO:0072089] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737] EHNGVPPSPDRAPPSRR 1 4.3 0.96364 -1.0957 11.9456 0 0 0 0 0 0 0 0 0 0 0 Q8NB12 SMYD1_HUMAN Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1) SMYD1 Homo sapiens (Human) heart development [GO:0007507]; methylation [GO:0032259]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] EFWAADIIFAER;IMWRVER;ISEGEELTVSYIDFLNVSEERK;SEGLYHEVVKLCR 4 11 0.978 -2.132 0 8.86722 9.703 0 9.77302 8.59238 0 7.60118 0 0 0 0 Q8NB14 UBP38_HUMAN Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) USP38 KIAA1891 Homo sapiens (Human) negative regulation of innate immune response [GO:0045824]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein K33-linked deubiquitination [GO:1990168]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; protein sequestering activity [GO:0140311] LSDLLTDFVQCIPK;LSITFCQQLVR;TSDGEKTLIEK 3 3.5 0.93581 -0.52211 0 0 5.30027 0 9.01229 0 0 0 0 0 0 5.44351 Q8NB16 MLKL_HUMAN Mixed lineage kinase domain-like protein (hMLKL) MLKL Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; protein homotrimerization [GO:0070207] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877] LAGFELR;QTFNKEIKTMK 2 3.8 0.97629 -1.479 0 0 0 8.76928 0 0 0 11.0513 0 0 0 11.7108 Q8NB25 F184A_HUMAN Protein FAM184A FAM184A C6orf60 Homo sapiens (Human) centriolar satellite [GO:0034451]; extracellular space [GO:0005615]; P-body [GO:0000932] DKLNLEEDK;DSLKETK;ITDLQEELR;IVTMSREVEEIR;MKQQALTEFEAYKHR;QQHEETIAAMK;QSKEHICRITDLQEELR;TLEELAWK;VTEELDLRR 9 7.7 0.95498 -0.97444 0 0 0 9.73547 10.4269 0 13.6681 0 0 10.6386 0 11.4101 Q8NB46 ANR52_HUMAN Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) ANKRD52 Homo sapiens (Human) NCSIAAAK;TCLHAAASGGNVECLNLLLSSGADLRRR 2 3.3 0.91739 -0.35946 5.17528 0 0 0 0 4.97237 4.38833 0 0 5.62433 0 0 Q8NB49 AT11C_HUMAN Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) ATP11C ATPIG ATPIQ Homo sapiens (Human) monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] AAVCTTLK;GADSAVFPR;INRQLIEAK;STCYACR;TIEESERK;TIEESERKEDR;VQNHEIELTKVHVERNAMDGYR 7 5.8 0.97481 -3.6814 0 0 5.82077 6.07249 6.70943 0 10.4644 5.54322 6.4774 0 6.87209 6.15662 Q8NB50 ZFP62_HUMAN Zinc finger protein 62 homolog (Zfp-62) ZFP62 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MKEDKSSIR;NCKCDECGK;SFKYNSR;SFNYRSVLDQHK;SIHFGDKPYKCDECGK;SNLTKHKR;SVHQGKQPYNCECGKSFNYR 7 10.8 0.97612 -5.227 0 0 7.14262 0 0 6.15945 0 6.02188 12.0827 3.99874 0 0 Q8NB59 SYT14_HUMAN Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV) SYT14 Homo sapiens (Human) membrane [GO:0016020] phospholipid binding [GO:0005543] CEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNK;NLAANRPPNGLFCCLK;QRNYAWETR;YGTLDVTFDYDSQEQK 4 12 0.97981 -2.0423 0 0 11.1371 10.5086 0 0 0 0 0 0 0 11.0249 Q8NB66 UN13C_HUMAN Protein unc-13 homolog C (Munc13-3) UNC13C Homo sapiens (Human) "chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075] DLEYLGK;DLGQLSKLKEHMIR;EYRQQKK;FYFECHNSTDRIK;IREKNRPEVFEVIQEMFQISK;KEKGIPSSQTYESMAIK;LSTPEPK;QMAELEEKILAGDSSSVDEK;SLILPYIHKLCKGMFTK 9 5.6 0.97646 -5.3758 11.1795 7.63183 9.03862 10.5948 0 9.26235 0 0 9.02306 0 8.68314 0 Q8NB78 KDM1B_HUMAN Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) KDM1B AOF1 C6orf193 LSD2 Homo sapiens (Human) epigenetic programing of female pronucleus [GO:0044726]; epigenetic regulation of gene expression [GO:0040029]; genomic imprinting [GO:0071514]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin binding [GO:0003682]; FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; zinc ion binding [GO:0008270] ATETTDEDEDGGSEK;SHKDGYDKYTTWK;VLEVSNHWWYSMLILPPLLK 3 5.8 0.95149 -0.70495 0 0 0 0 4.05111 0 9.16651 8.93251 0 0 0 0 Q8NB90 AFG2A_HUMAN ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) AFG2A SPAF SPATA5 Homo sapiens (Human) brain development [GO:0007420]; cell differentiation [GO:0030154]; ribosomal large subunit biogenesis [GO:0042273]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; preribosome binding [GO:1990275] GVLLYGPPGTGK;ITLKDFLQAMNDIRPSAMR 2 3.5 0.91944 -0.43798 0 0 0 0 0 0 0 0 8.52242 0 0 0 Q8NB91 FANCB_HUMAN Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) FANCB Homo sapiens (Human) interstrand cross-link repair [GO:0036297]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] ELVTLSSLSSAIAKHESNFMQRCEVSK;IMCCNCVSDFR;TPILHVRRMVFDR 3 5.9 0.3667 0.22988 0 0 0 0 5.95149 0 0 9.33635 0 0 0 7.81436 Q8NBA8 DTWD2_HUMAN tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2) DTWD2 Homo sapiens (Human) RNA glycosylation [GO:0141217]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432] DIFYKNSLFRHPK;IGRRFSEER 2 7.4 0.97626 -1.4836 0 0 4.07159 0 0 0 12.6621 0 0 0 0 0 Q8NBB2 STAS1_HUMAN Putative uncharacterized protein ST20-AS1 (ST20 antisense RNA 1) (ST20 antisense gene protein 1) ST20-AS1 C15orf37 Homo sapiens (Human) MPRPASESWSPIQSR 1 11.5 0.78333 0.025919 0 0 0 0 7.65141 0 0 0 0 0 0 0 Q8NBB4 ZSCA1_HUMAN Zinc finger and SCAN domain-containing protein 1 ZSCAN1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AFPWMVHLIDHQK;MRTWVQSQGPR 2 5.9 0.95514 -0.9789 0 0 11.7178 0 0 0 0 0 0 10.4319 0 0 Q8NBC4 CT203_HUMAN Uncharacterized protein C20orf203 C20orf203 Homo sapiens (Human) cytoplasm [GO:0005737] LSKVGRR 1 3.6 0.649 0.1711 0 0 0 0 8.262 8.36479 10.8548 0 0 0 0 0 Q8NBF1 GLIS1_HUMAN Zinc finger protein GLIS1 (GLI-similar 1) GLIS1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AHSAKEQQVRK;CMFEGCSK 2 3.1 0.97989 -1.8209 0 0 0 0 0 0 12.4044 0 0 0 0 6.56715 Q8NBF2 NHLC2_HUMAN NHL repeat-containing protein 2 NHLRC2 Homo sapiens (Human) cytosol [GO:0005829]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093] NELTKGTCLR 1 1.4 0.88882 -0.18419 0 0 13.091 0 0 0 0 0 0 0 0 0 Q8NBF6 AVL9_HUMAN Late secretory pathway protein AVL9 homolog AVL9 KIAA0241 Homo sapiens (Human) cell migration [GO:0016477] cytoplasm [GO:0005737]; membrane [GO:0016020]; recycling endosome [GO:0055037] HKVLILFKLILLEK;LLNPTTADLR;SVCVLSK;TEEPLFQVEDSSK 4 6.8 0.91224 -0.32277 0 4.61736 0 0 9.93391 0 0 8.9863 0 0 0 11.0399 Q8NBH2 KY_HUMAN Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018] peptidase activity [GO:0008233] AIWIWICHHIEYDIAAAQEKDR 1 3.3 0.98011 -1.5627 0 0 0 0 12.528 0 0 0 0 0 0 0 Q8NBI6 XXLT1_HUMAN "Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" XXYLT1 C3orf21 PSEC0251 Homo sapiens (Human) O-glycan processing [GO:0016266] endoplasmic reticulum membrane [GO:0005789] "magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyl alpha-1,3-xylosyltransferase activity [GO:0140560]" DHGYSDVFEAYFR;LFPIVEAMQK;VALRSLLRLAK 3 8.7 0.97493 -1.39 0 10.4588 0 8.31374 7.91001 0 0 0 0 0 0 0 Q8NBI6 XXLT1_HUMAN "Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" XXYLT1 C3orf21 PSEC0251 Homo sapiens (Human) O-glycan processing [GO:0016266] endoplasmic reticulum membrane [GO:0005789] "magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyl alpha-1,3-xylosyltransferase activity [GO:0140560]" DHGYSDVFEAYFR;WSWTSQPLELHTFWQFR 2 16 0.64254 0.17279 0 0 0 0 0 0 0 0 0 10.4931 0 0 Q8NBJ4 GOLM1_HUMAN Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] KNEFQGELEK;NQTNLER 2 4.2 0.95072 -0.66894 0 0 0 9.64252 0 0 0 0 0 9.19187 9.65177 0 Q8NBJ5 GT251_HUMAN Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) COLGALT1 GLT25D1 PSEC0241 Homo sapiens (Human) collagen fibril organization [GO:0030199]; positive regulation of collagen fibril organization [GO:1904028] endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] procollagen galactosyltransferase activity [GO:0050211] EQQALSR;FISAPTK;HWSDSRYEHVMK;HWSDSRYEHVMKLR;YEHVMKLR 5 4.5 0.97364 -1.4061 0 4.53462 0 0 0 0 0 0 11.1662 0 0 11.4392 Q8NBJ7 SUMF2_HUMAN Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) SUMF2 PSEC0171 UNQ1968/PRO4500 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ATQPMKSVLWWLPVEK;HGLPLLPLLSLLVGAWLK 2 11.3 0.7846 0.021081 0 0 0 0 0 0 0 0 0 0 3.73801 10.3611 Q8NBK3 SUMF1_HUMAN Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) SUMF1 PSEC0152 UNQ3037/PRO9852 Homo sapiens (Human) glycosphingolipid catabolic process [GO:0046479]; post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491] TNIQQAVAAAPWWLPVK 1 4.5 0.78397 0.030412 0 0 0 0 10.6934 0 0 0 0 6.79533 0 0 Q8NBL1 PGLT1_HUMAN Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63) POGLUT1 C3orf9 CLP46 KTELC1 MDSRP MDS010 UNQ490/PRO1006 Homo sapiens (Human) axial mesoderm development [GO:0048318]; circulatory system development [GO:0072359]; gastrulation [GO:0007369]; muscle tissue development [GO:0060537]; paraxial mesoderm development [GO:0048339]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; regulation of gastrulation [GO:0010470]; somitogenesis [GO:0001756] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] ESGSKWK;GVAASFR;GYDQIIPKMLKTEL 3 7.1 0.9803 -1.8152 0 0 0 9.06749 0 9.22822 8.75689 10.6377 7.41253 0 11.835 9.33764 Q8NBM8 PCYXL_HUMAN Prenylcysteine oxidase 1-like (EC 1.8.3.-) PCYOX1L PSEC0105 Homo sapiens (Human) prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] prenylcysteine oxidase activity [GO:0001735] QPQEAAVWR 1 1.8 0.93698 -0.55682 0 0 0 0 0 0 7.84844 0 0 0 0 0 Q8NBN3 TM87A_HUMAN Transmembrane protein 87A (Elkin1) TMEM87A PSEC0094 Homo sapiens (Human) "cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ruffle [GO:0001726] AVFYAEFQNIRYK;QEAKENGTNLTFIGDK;TLVIIVSLGYGIVKPRLGVTLHK 3 9.4 0.977 -1.4977 0 0 13.2514 0 0 0 0 0 0 0 5.0256 0 Q8NBP0 TTC13_HUMAN Tetratricopeptide repeat protein 13 (TPR repeat protein 13) TTC13 PSEC0076 Homo sapiens (Human) DGFTVNTK 1 0.9 0.91405 -0.39033 0 0 0 0 0 0 7.79824 0 0 0 0 0 Q8NBP5 MFSD9_HUMAN Major facilitator superfamily domain-containing protein 9 MFSD9 PSEC0066 Homo sapiens (Human) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LVSETAER;VPAGIFKHTLSISRALLSDVVPEK 2 6.8 0.91104 -0.28687 0 0 0 9.74382 0 0 0 0 9.81881 0 0 0 Q8NBP7 PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) PCSK9 NARC1 PSEC0052 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; kidney development [GO:0001822]; lipoprotein metabolic process [GO:0042157]; liver development [GO:0001889]; low-density lipoprotein particle receptor catabolic process [GO:0032802]; lysosomal transport [GO:0007041]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of low-density lipoprotein particle receptor binding [GO:1905596]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of receptor internalization [GO:0002091]; negative regulation of receptor recycling [GO:0001920]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; phospholipid metabolic process [GO:0006644]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of receptor internalization [GO:0002092]; protein autoprocessing [GO:0016540]; regulation of neuron apoptotic process [GO:0043523]; regulation of signaling receptor activity [GO:0010469]; triglyceride metabolic process [GO:0006641] cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; PCSK9-AnxA2 complex [GO:1990667]; PCSK9-LDLR complex [GO:1990666]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] apolipoprotein binding [GO:0034185]; apolipoprotein receptor binding [GO:0034190]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]; signaling receptor inhibitor activity [GO:0030547]; sodium channel inhibitor activity [GO:0019871]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor binding [GO:0070326] EETHLSQSERTAR;LPGTYVVVLKEETHLSQSER;LQAQAARR;LQAQAARRGYLTK;VLNAACQR 5 6.4 0.96625 -1.273 8.07334 10.3635 0 5.07558 3.98787 0 0 0 10.8096 8.83801 0 0 Q8NBQ5 DHB11_HUMAN Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2) HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233 Homo sapiens (Human) androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] "estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" LVLWDINKHGLEETAAK 1 5.7 0.9184 -0.43557 0 0 0 0 0 0 0 0 0 0 8.44294 0 Q8NBR0 P5I13_HUMAN Tumor protein p53-inducible protein 13 (Damage-stimulated cytoplasmic protein 1) TP53I13 DSCP1 Homo sapiens (Human) negative regulation of cell cycle [GO:0045786]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] SALRFPSASPGSLK 1 3.6 0.92129 -0.43979 0 0 0 0 0 0 0 0 0 0 0 11.2916 Q8NBR6 MINY2_HUMAN Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) MINDY2 FAM63B KIAA1164 Homo sapiens (Human) proteolysis [GO:0006508] nucleoplasm [GO:0005654] cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K11-linked polyubiquitin modification-dependent protein binding [GO:0071795]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530] FPGQSVYHIKWIQWK;GQLYLLVTDQGFLTEEK 2 5.2 0.93006 -0.46918 0 0 0 0 0 0 0 11.7546 10.795 0 0 0 Q8NBS3 S4A11_HUMAN Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) SLC4A11 BTR1 Homo sapiens (Human) bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular hypotonic response [GO:0071476]; cellular response to oxidative stress [GO:0034599]; fluid transport [GO:0042044]; intracellular monoatomic cation homeostasis [GO:0030003]; monoatomic anion transport [GO:0006820]; monoatomic ion homeostasis [GO:0050801]; proton transmembrane transport [GO:1902600]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of mitochondrial membrane potential [GO:0051881]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] active borate transmembrane transporter activity [GO:0046715]; bicarbonate transmembrane transporter activity [GO:0015106]; protein dimerization activity [GO:0046983]; proton channel activity [GO:0015252]; proton transmembrane transporter activity [GO:0015078]; sodium channel activity [GO:0005272]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; water transmembrane transporter activity [GO:0005372] LLETRTEEEFK;MSQVGGR;RSTEEIIALFISITFVLDAVK 3 4.4 0.9371 -0.57632 0 0 7.52427 0 8.0898 7.94726 0 0 0 8.16511 11.1081 0 Q8NBS9 TXND5_HUMAN Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) TXNDC5 TLP46 UNQ364/PRO700 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457] azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] EFPGLAGVK;FVLSQAKDEL;GYPTLLLFR;LLPLLARPAALTALLLLLLGHGGGGR;NICSKYSVR;YSVRGYPTLLLFRGGK 6 15.3 0.74003 0.10403 0 12.5877 0 10.5602 0 3.55655 12.569 9.15805 9.54525 0 0 8.39814 Q8NBT0 POC1A_HUMAN POC1 centriolar protein homolog A (Pix2) (Proteome of centriole protein 1A) (WD repeat-containing protein 51A) POC1A WDR51A Homo sapiens (Human) cilium assembly [GO:0060271] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] LKQCLENQQLIMQR 1 3.9 0.92179 -0.44318 0 0 0 0 9.48525 0 0 0 0 0 0 0 Q8NBT3 TM145_HUMAN Transmembrane protein 145 TMEM145 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] membrane [GO:0016020] ILAKLLFSSSFLIFLLMLILLGK;ISHAGSVK;LLFSSSFLIFLLMLILLGK;LLPPLLLLLLSLPPRAR;LLPPLLLLLLSLPPRARAK 5 10.1 0.90997 -0.29094 0 5.02538 0 0 6.04518 4.8511 0 5.23523 0 3.84187 10.7471 0 Q8NBU5 ATAD1_HUMAN Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) ATAD1 FNP001 Homo sapiens (Human) "extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of receptor internalization [GO:0002092]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]" cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane protein dislocase activity [GO:0140567] AIEKMKK;FHINQPALKQREAILK;KKHLFENSR;WMVDAIDPTRK 4 11.9 0.9768 -2.205 13.1992 0 0 0 0 11.0938 13.2949 14.4325 0 0 0 0 Q8NBV8 SYT8_HUMAN Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII) SYT8 Homo sapiens (Human) acrosome reaction [GO:0007340]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle-mediated transport [GO:0016192] acrosomal vesicle [GO:0001669]; axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; SNARE binding [GO:0000149] YVPSSGR 1 1.8 0.91095 -0.32687 0 0 7.21936 0 0 0 0 0 0 0 0 0 Q8NBW4 S38A9_HUMAN Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) SLC38A9 URLC11 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; cellular response to amino acid stimulus [GO:0071230]; glutamine transport [GO:0006868]; L-arginine transmembrane transport [GO:1903826]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263] FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; cholesterol binding [GO:0015485]; guanyl-nucleotide exchange factor activity [GO:0005085]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-leucine transmembrane transporter activity [GO:0015190]; metal ion binding [GO:0046872]; sterol sensor activity [GO:0032935] LTTPADK 1 1.2 0.92884 -0.48198 0 0 0 0 0 0 10.1463 0 0 0 0 0 Q8NBX0 SCPDL_HUMAN Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) SCCPDH CGI-49 Homo sapiens (Human) glycolipid biosynthetic process [GO:0009247] extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] oxidoreductase activity [GO:0016491] LIDRLNK;LRNVSNLKPVPLIGPKLK;NKPNIKICTQVK;SAIYGFGDQSNLR 4 11.7 0.97287 -2.5947 0 0 0 6.53708 0 0 0 0 0 0 9.97484 0 Q8NBZ0 IN80E_HUMAN INO80 complex subunit E (Coiled-coil domain-containing protein 95) INO80E CCDC95 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] MPPPTILSTVPR 1 4.9 0.80382 0.01339 0 0 0 0 0 10.0341 0 0 0 0 0 0 Q8NBZ7 UXS1_HUMAN UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1) UXS1 UNQ2538/PRO6079 Homo sapiens (Human) D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580] identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; UDP-glucuronate decarboxylase activity [GO:0048040] ELEYQANNQYIPKPKPARIK;VAETMCYAYMKQEGVEVRVAR 2 9.8 0.86974 -0.10119 0 0 4.27337 0 0 0 11.2422 0 0 0 8.6536 0 Q8NC01 CLC1A_HUMAN C-type lectin domain family 1 member A (C-type lectin-like receptor 1) (CLEC-1) CLEC1A CLEC1 UNQ569/PRO1131 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; signal transduction [GO:0007165] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] LCRELYNK 1 2.9 0.98028 -1.5553 0 0 0 0 0 0 0 9.43908 0 0 0 0 Q8NC06 ACBD4_HUMAN Acyl-CoA-binding domain-containing protein 4 ACBD4 HMFT0700 Homo sapiens (Human) fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737] fatty-acyl-CoA binding [GO:0000062] GPRCSSSSCGPSSSSGSSECFGPKR 1 7.3 0.66569 0.16893 0 0 7.03771 0 0 0 0 0 0 0 0 0 Q8NC26 ZN114_HUMAN Zinc finger protein 114 ZNF114 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] extracellular exosome [GO:0070062]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TCGKDFAKSSGLK;YTHIRSHTGEKPYK 2 6.5 0.93661 -0.52635 0 0 0 0 0 0 0 0 10.3966 0 0 11.0792 Q8NC38 CA213_HUMAN Putative uncharacterized protein ZNF436-AS1 (ZNF436 antisense RNA 1) (ZNF436 antisense gene protein 1) ZNF436-AS1 C1orf213 Homo sapiens (Human) QIPETTEAGR 1 7.9 0.91064 -0.31851 0 0 0 0 0 0 0 9.03472 9.21096 0 0 0 Q8NC51 SERB1_HUMAN SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) SERBP1 PAIRBP1 CGI-55 Homo sapiens (Human) negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371] EAGGGGVGGPGAK;RFEKPLEEKGEGGEFSVDRPIIDRPIR;SAAQAAAQTNSNAAGK;SSASAPDVDDPEAFPALA 4 18.1 0 16.999 0 8.20369 7.15856 8.54693 8.52548 8.64681 0 10.4263 0 10.8535 11.4899 10.9841 Q8NC56 LEMD2_HUMAN LEM domain-containing protein 2 (hLEM2) LEMD2 Homo sapiens (Human) heart formation [GO:0060914]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; neurogenesis [GO:0022008]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; protein localization to chromatin [GO:0071168]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; spindle [GO:0005819] ATQGPGLAAR;AVEFLASNESR;LLPVDCERK 3 6 0.91565 -0.37327 12.0613 7.81858 0 0 0 0 0 9.53162 0 0 0 0 Q8NC60 NOA1_HUMAN Nitric oxide-associated protein 1 NOA1 C4orf14 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial ribosome assembly [GO:0061668]; mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; RNA binding [GO:0003723] ELPYDPVDTEGFGEGGDMQER 1 3 0.65269 0.16939 0 0 0 0 0 0 0 8.39874 0 0 0 0 Q8NC67 NETO2_HUMAN Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) NETO2 BTCL2 UNQ1926/PRO4401 Homo sapiens (Human) neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696] glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] ionotropic glutamate receptor binding [GO:0035255] TFNSTFKK 1 1.5 0.92612 -0.45275 0 8.96622 0 0 0 0 0 0 0 0 0 0 Q8NC74 RB8NL_HUMAN RBBP8 N-terminal-like protein RBBP8NL C20orf151 Homo sapiens (Human) extracellular space [GO:0005615] DAEDHSPSPNSSPWEET;LKEIHEKEVLGLQNK 2 4.8 0.97317 -1.4169 0 0 0 0 0 0 0 0 0 0 7.9978 0 Q8NC96 NECP1_HUMAN Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) NECAP1 Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GDAFDFNVSLQDHFK 1 5.5 0.78362 0.025919 0 0 0 0 0 0 0 0 0 0 0 5.16249 Q8NCA5 FA98A_HUMAN Protein FAM98A FAM98A Homo sapiens (Human) "lysosome localization [GO:0032418]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of ruffle assembly [GO:1900029]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723] GGGRGNK 1 1.4 0.74099 0.10656 12.6848 0 0 0 0 0 0 0 0 0 0 0 Q8NCB2 CAMKV_HUMAN CaM kinase-like vesicle-associated protein CAMKV Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804]; regulation of modification of postsynaptic structure [GO:0099159]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516] EVFDWILDQGYYSER;ITAEEAISHEWISGNAASDKNIK;KNYNQPSEVTDRYDLGQVIK;SATPATDGR 4 13.4 0.97923 -1.8901 0 0 0 0 0 0 10.8595 0 0 2.79035 0 9.7127 Q8NCC3 PAG15_HUMAN Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (PLA2G15) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] acylglycerol O-acyltransferase activity [GO:0016411]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270] GEDVRGAPYDWRR;HPPVVLVPGDLGNQLEAK;IPVIGPLK 3 9.5 0.9804 -1.6683 0 7.5763 0 7.20555 7.05007 0 8.97968 0 0 0 7.41126 0 Q8NCC5 SPX3_HUMAN Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 Homo sapiens (Human) xenobiotic transmembrane transport [GO:0006855] endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765] xenobiotic transmembrane transporter activity [GO:0042910] EIFSLVLRRQAHILR 1 3.1 0.85998 -0.082523 0 0 0 0 4.17528 0 0 0 0 0 0 0 Q8NCD3 HJURP_HUMAN Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) HJURP FAKTS FLEG1 URLC9 Homo sapiens (Human) CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA binding [GO:0051101]; regulation of protein-containing complex assembly [GO:0043254] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]" DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802] EIEIRFDQLHREYCLSPR;EVPGHGR;NRYDEIK;SRMNKTYCK;TFIMQNWNSRR 5 7 0.97476 -3.6225 0 8.52329 0 0 0 0 0 0 0 9.79858 0 9.16461 Q8NCE0 SEN2_HUMAN tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) TSEN2 SEN2 Homo sapiens (Human) "mRNA processing [GO:0006397]; tRNA processing [GO:0008033]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] QGQDESTVRRILK;VQEVILSR;WVSSRER 3 6 0.97433 -3.5315 0 0 0 0 0 0 0 0 0 10.0511 0 0 Q8NCF5 NF2IP_HUMAN "NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)" NFATC2IP NIP45 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNSNSDSEGEDR 1 2.9 0.89642 -0.24108 0 0 0 0 0 0 0 0 0 5.07301 0 0 Q8NCG7 DGLB_HUMAN Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) DAGLB Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; diacylglycerol catabolic process [GO:0046340]; monoacylglycerol biosynthetic process [GO:0006640]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727] lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lipase activity [GO:0016298]; metal ion binding [GO:0046872]; monoacylglycerol lipase activity [GO:0047372]; triacylglycerol lipase activity [GO:0004806] LLCCCIGK 1 1.2 0.93665 -0.55157 0 0 0 0 0 8.89081 0 0 0 0 0 0 Q8NCG7 DGLB_HUMAN Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) DAGLB Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; diacylglycerol catabolic process [GO:0046340]; monoacylglycerol biosynthetic process [GO:0006640]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727] lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lipase activity [GO:0016298]; metal ion binding [GO:0046872]; monoacylglycerol lipase activity [GO:0047372]; triacylglycerol lipase activity [GO:0004806] SLPRWSAMPQGAPSCR;TISGTTK 2 4.2 0.91616 -0.43074 0 0 0 0 0 0 0 11.5834 0 0 10.2921 0 Q8NCI6 GLBL3_HUMAN Beta-galactosidase-1-like protein 3 (EC 3.2.1.-) GLB1L3 Homo sapiens (Human) galactose catabolic process [GO:0019388] vacuole [GO:0005773] beta-galactosidase activity [GO:0004565] FNWSHLTPLELKNR;VPKLPPK 2 3.2 0.82628 -0.020248 0 0 0 3.72181 0 0 0 0 0 0 10.2535 0 Q8NCJ5 SPRY3_HUMAN SPRY domain-containing protein 3 SPRYD3 Homo sapiens (Human) VDLHPLSG 1 1.8 0.91428 -0.39033 0 0 0 0 0 0 0 0 8.68415 0 0 0 Q8NCK3 ZN485_HUMAN Zinc finger protein 485 ZNF485 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGRAFRDNSTVLEHQK;CIECGKFLK;NYKCKECGK;SVMMEKGLDWEGRSSTEK 4 11.8 0.95202 -0.70795 6.9479 7.57304 0 0 0 0 0 0 8.14995 8.09054 0 0 Q8NCK7 MOT11_HUMAN Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11) SLC16A11 MCT11 Homo sapiens (Human) carboxylic acid transmembrane transport [GO:1905039]; lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293] PAPQRKHR 1 1.7 0.97532 -1.4575 0 0 0 0 0 0 0 14.8446 0 0 0 0 Q8NCL4 GALT6_HUMAN Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6) GALNT6 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EEATEKPWLK;EEATEKPWLKSLVSRK;GNFDWSLTFGWETLPPHEK;RKDETYPIK;VVRQEERK 5 8.4 0.96583 -1.1275 0 0 0 0 0 11.0973 0 0 0 12.919 0 0 Q8NCL8 TM116_HUMAN Transmembrane protein 116 TMEM116 Homo sapiens (Human) signal transduction [GO:0007165] membrane [GO:0016020] LTKPQDTK 1 3.3 0.91028 -0.2998 0 0 13.7021 0 0 10.6344 0 0 0 0 0 0 Q8NCL9 APCDL_HUMAN Protein APCDD1-like (Adenomatosis polyposis coli down-regulated 1 protein-like) APCDD1L Homo sapiens (Human) negative regulation of Wnt signaling pathway [GO:0030178] plasma membrane [GO:0005886] Wnt-protein binding [GO:0017147] AGRDCARR;GTPSTRVR;HPSTGGLHIAPFPLLPLVLGLAFLHWL;LNQTRAGRDCAR 4 9.6 0.97312 -2.5225 0 5.88333 0 6.82146 0 0 0 0 0 0 11.7986 0 Q8NCM8 DYHC2_HUMAN Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) DYNC2H1 DHC1B DHC2 DNCH2 DYH1B KIAA1997 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; coronary vasculature development [GO:0060976]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; forebrain development [GO:0030900]; Golgi organization [GO:0007030]; intraciliary retrograde transport [GO:0035721]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]; protein processing [GO:0016485]; spinal cord motor neuron differentiation [GO:0021522] 9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; axoneme [GO:0005930]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AEDLFRR;DIVNQVGDNR;ELLTPQQHYDWGLR;FQSRTSEAAKLEAEVSK;FSLAAFLRLFQR;IFVGLVK;ILGRSITAGSK;LEFTKEVFHWAR;LLQQEEDKK;LLTMPSGER;LNTMSKFTFTDCTRFDALIK;LSQTCMVISTNTGR;NLSEVVNSIVWVRQLELKVDDTIK;RQSHLQAGVSKLNEAK;SDHTCCVQMVDSEFQYTYEYQGNASK;SIMTDIKKDNR;SLNEFLEEKR;TESVKALGGLLGRQVLVFNCDEGIDVK;TKLLQQEEDK;TVCELLGK;TYESWTPEQISK;VLQSYLKQFFNSSVIDVFNQRNK;VPPPNDR 23 7.2 0.97839 -6.8272 13.4409 7.36194 9.29418 11.6666 10.6768 10.6236 12.7335 9.66982 10.3858 11.4058 8.26322 7.35984 Q8NCN2 ZBT34_HUMAN Zinc finger and BTB domain-containing protein 34 ZBTB34 KIAA1993 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LCDIIVHIQGQPFR;LICIYCGKSFNQK;TDVYVEQK 3 7 0.97956 -1.8481 0 0 0 0 0 0 0 0 0 8.68275 9.1899 10.2677 Q8NCN4 RN169_HUMAN E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) RNF169 KIAA1991 Homo sapiens (Human) DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair [GO:2000780]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842] AADAAGPGCPRCRAR;EQFEGLGSTPDAKLDK 2 4.4 0.91793 -0.35814 0 0 0 0 0 6.82107 0 0 0 0 0 10.755 Q8NCN5 PDPR_HUMAN "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR KIAA1990 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253] TSPLYDRLDAQGARWMEK 1 2 0.8625 -0.083005 0 0 0 0 0 0 0 0 8.02098 0 0 0 Q8NCP5 ZBT44_HUMAN Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851) ZBTB44 BTBD15 ZNF851 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] TIPVCRESR;VSRHIIRKPR 2 3.3 0.97458 -1.3863 0 0 0 0 0 0 0 12.1032 0 0 4.1147 0 Q8NCQ5 FBX15_HUMAN F-box only protein 15 FBXO15 FBX15 Homo sapiens (Human) cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ILQQHWLGLQTLRGPSR;LSAGSAALR 2 5.1 0.90907 -0.27857 0 0 0 0 0 0 0 10.3012 0 0 0 0 Q8NCR3 MFI_HUMAN Protein MFI (Mitochondrial fission factor interactor) MFI C11orf65 Homo sapiens (Human) negative regulation of mitochondrial fission [GO:0090258]; negative regulation of protein targeting to mitochondrion [GO:1903215] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] AARVIQQAWK;IFTHRPIEDLCANSPR 2 8.3 0.9737 -1.413 0 0 0 9.99166 0 0 0 0 0 3.04693 0 0 Q8NCR6 SMIP6_HUMAN Sperm microtubule inner protein 6 (Ciliated bronchial epithelial protein 1) (Spermatid-specific manchette-related protein 1) (Testis development protein NYD-SP22) SPMIP6 C9orf24 CBE1 SMRP1 Homo sapiens (Human) cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; protein-containing complex assembly [GO:0065003]; spermatogenesis [GO:0007283] axonemal A tubule inner sheath [GO:0160111]; cytosol [GO:0005829]; manchette [GO:0002177]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm midpiece [GO:0097225] alpha-tubulin binding [GO:0043014] LPFHGYESACSGR 1 5 0.80558 0.013792 0 0 6.98789 0 0 0 0 0 0 0 0 0 Q8NCS7 CTL5_HUMAN Choline transporter-like protein 5 (Solute carrier family 44 member 5) SLC44A5 CTL5 Homo sapiens (Human) choline transport [GO:0015871]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085] membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857] IVLEYLDHR;NGTLTIGSKMMFQDGNGGTR;QLVPQKQKE 3 5.3 0.9731 -2.5151 0 0 0 0 0 0 6.04348 0 0 0 8.19751 0 Q8NCT1 ARRD4_HUMAN Arrestin domain-containing protein 4 ARRDC4 Homo sapiens (Human) extracellular vesicle biogenesis [GO:0140112]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein K63-linked ubiquitination [GO:0070534]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AAIFQTQTYLASGKTK;LEAQGRATAAWGPSTCPR 2 8.1 0.95581 -0.85588 0 0 6.98413 7.04952 0 0 0 0 0 0 0 0 Q8NCT3 MACA2_HUMAN Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-) MATCAP2 KIAA0895 Homo sapiens (Human) proteolysis [GO:0006508] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] KLHWPEQELAK;KPSKSPNTSR 2 4.1 0.96397 -1.1916 9.02359 0 0 10.5461 0 0 0 0 0 0 0 0 Q8NCU1 CC197_HUMAN Uncharacterized protein CCDC197 (Coiled-coil domain-containing protein 197) CCDC197 C14orf48 LINC00521 Homo sapiens (Human) HKLFEDYLIK 1 7.9 0.012245 0.86376 16.0965 16.1228 6.97074 14.5402 0 0 15.6148 15.3505 15.6292 15.191 14.8977 0 Q8NCU4 CC191_HUMAN Coiled-coil domain-containing protein 191 CCDC191 KIAA1407 Homo sapiens (Human) phosphatase binding [GO:0019902] AAWKIEKK;AGTLSDWK;LILDHRIK;QLMTPHPILKGR;RKALEAK;SAFLEAQCLVQEEKKR;TVKAAWK;YFAAWHKLILDHR 8 13.2 0.97577 -4.3312 0 0 0 8.4429 0 0 10.137 10.9115 9.27086 0 9.21313 0 Q8NCU7 C2C4A_HUMAN C2 calcium-dependent domain-containing protein 4A (Nuclear-localized factor 1) (Protein FAM148A) C2CD4A FAM148A NLF1 Homo sapiens (Human) positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ASFDQDFCFDGLSEDEVR;LEAEGTVALGR;MWCLERLRLGPECLR 3 11.9 0.88189 -0.17748 0 0 0 7.68089 0 0 0 0 0 7.75087 0 0 Q8NCU8 MTLN_HUMAN Mitoregulin (Micropeptide in mitochondria) (Micropeptide regulator of beta-oxidation) (Small integral membrane protein 37) (lncRNA-encoded micropeptide) MTLN LEMP LINC00116 MOXI MPM NCRNA00116 SMIM37 Homo sapiens (Human) cellular respiration [GO:0045333]; fatty acid beta-oxidation [GO:0006635]; lipid metabolic process [GO:0006629]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of sequestering of calcium ion [GO:0051284]; striated muscle cell differentiation [GO:0051146]; triglyceride homeostasis [GO:0070328] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] TLQLSVLVAFASGVLLGWQANRLRR 1 44.6 0.66608 0.16893 0 0 0 5.58201 0 0 0 0 0 0 6.47403 0 Q8NCV1 ADAD2_HUMAN Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like) ADAD2 TENRL Homo sapiens (Human) adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251] APGGEELK;DSGPGAGAGVGELGAARAWENLGEQMGKAPR 2 5.9 0.96678 -1.2693 0 0 0 0 0 0 0 11.8927 0 0 10.973 0 Q8NCW6 GLT11_HUMAN Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) GALNT11 Homo sapiens (Human) cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]; regulation of Notch signaling pathway [GO:0008593] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] DLGYQKHAFNMLISDR;MGSVTVR 2 3.8 0.95983 -1.051 0 0 0 0 6.39455 0 0 6.65807 0 0 0 0 Q8NCX0 CC150_HUMAN Coiled-coil domain-containing protein 150 CCDC150 Homo sapiens (Human) AQDEVQR;CQELEETVRHLK;EVNKTEK;QFQTERETTK;QQLRAVK;SLLEEKER;VEAELHAERIEALRK;VISPIQNEAICAGK;VTIMLENVLASHSK 9 8.5 0.97676 -5.4183 0 10.5144 10.8721 9.1534 6.573 7.12143 12.0264 0 0 0 0 9.458 Q8NCY6 MSD4_HUMAN Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) MSANTD4 KIAA1826 DC25 Homo sapiens (Human) nucleus [GO:0005634] DRLQFLKFESEK;LRIQKEGHLQ;RENELPDFPHIDEFFTLNSTPSR 3 13 0.97194 -2.6999 0 0 0 10.5152 0 0 0 0 0 8.4778 0 0 Q8ND04 SMG8_HUMAN Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) SMG8 ABC2 C17orf71 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of protein kinase activity [GO:0045859]" cytosol [GO:0005829] AGPVSLR;ENVQLMSYKVLR;GPCFPPKENVQLMSYK;LNCRPCPPR;LYEVAIDGK;TEKRPNFVDR;VEPPRNQDPAHPDKPKK 7 7.2 0.97385 -2.4221 0 0 0 10.6471 6.42212 0 0 0 0 0 10.9232 0 Q8ND07 BBOF1_HUMAN Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176) BBOF1 C14orf45 CCDC176 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; motile cilium assembly [GO:0044458]; negative regulation of microtubule depolymerization [GO:0007026]; protein stabilization [GO:0050821]; single fertilization [GO:0007338]; sperm axoneme assembly [GO:0007288] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] AHHEAIVQLNDAGRNVFKENDYLQK;DIMSVLSYLKKQDQEK;ENLRNTERIHQETLR;LIKTDESVVDRAK;QIAQAAFNLK;QQILISRKHYK 6 17 0.97506 -3.6164 2.55078 0 8.85066 0 6.83276 7.64328 0 11.8795 0 0 0 11.7534 Q8ND23 CARL3_HUMAN "Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)" CARMIL3 C14orf121 LRRC16B Homo sapiens (Human) cell migration [GO:0016477]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] GLFHFRRPR;GLQALGQTFGANPAFASSLRYLDLSK;TLPARNAK;VAEGHNK 4 3.6 0.97787 -2.1578 0 11.4825 11.5012 0 0 0 9.10557 10.3149 0 0 0 0 Q8ND24 RN214_HUMAN RING finger protein 214 RNF214 Homo sapiens (Human) metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] AEILSLESRKELLVLK;LEKILEK 2 3.3 0.96427 -1.1729 0 0 0 9.65657 0 0 0 0 0 0 0 0 Q8ND30 LIPB2_HUMAN Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) PPFIBP2 Homo sapiens (Human) neuromuscular junction development [GO:0007528] cytosol [GO:0005829]; extracellular space [GO:0005615]; presynaptic active zone [GO:0048786] identical protein binding [GO:0042802] MGMETLLLANEDK;QEEKSALLDHIWVTRWLDDIGLPQYK 2 4.5 0.8148 -0.0013839 0 0 0 0 0 0 0 0 0 4.23289 10.0744 0 Q8ND56 LS14A_HUMAN Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A C19orf13 FAM61A RAP55 RAP55A Homo sapiens (Human) defense response to virus [GO:0051607]; mitotic spindle assembly [GO:0090307]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; RIG-I signaling pathway [GO:0039529]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] QEKPVNGEDK;TQLSQGR 2 3.7 0.96295 -1.0816 0 0 0 8.89515 0 0 0 9.25432 0 7.63909 0 0 Q8ND61 CC020_HUMAN Uncharacterized protein C3orf20 C3orf20 Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020] GRNISYPMILR;NISYPMILRNYKAK;QVRTHQETLNR;STLSPTMARQVR;THPERLPK 5 4.9 0.98017 -2.0083 0 7.83112 0 0 0 5.56047 0 10.8755 9.25155 10.3216 4.57162 0 Q8ND71 GIMA8_HUMAN GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT) GIMAP8 IAN9 IANT Homo sapiens (Human) regulation of T cell apoptotic process [GO:0070232] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] GTP binding [GO:0005525] FSDQTVIKMCQR 1 1.8 0.92416 -0.44864 0 0 0 0 0 0 0 0 0 7.69947 0 0 Q8ND76 CCNY_HUMAN Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) CCNY C10orf9 CBCP1 CFP1 Homo sapiens (Human) cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of autophagy [GO:0010508]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; regulation of canonical Wnt signaling pathway [GO:0060828]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901] LESYRPDTDLSR 1 3.5 0.80649 0.011579 5.77043 0 0 0 0 0 0 0 0 0 0 0 Q8ND82 Z280C_HUMAN Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) ZNF280C SUHW3 ZNF633 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EGMKNTSYVLK;NTSYVLKHPSTSK 2 2.3 0.98055 -1.7212 0 0 0 0 0 0 0 0 10.0556 0 0 0 Q8ND83 SLAI1_HUMAN SLAIN motif-containing protein 1 SLAIN1 C13orf32 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] LLLFFRFK 1 1.9 0.97944 -1.5439 0 0 0 0 0 0 0 0 0 7.50216 0 0 Q8ND90 PNMA1_HUMAN Paraneoplastic antigen Ma1 (37 kDa neuronal protein) (Neuron- and testis-specific protein 1) PNMA1 MA1 Homo sapiens (Human) inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; nucleolus [GO:0005730] LHLFLAR 1 2 0.91189 -0.32127 0 0 8.92582 0 5.984 5.34533 0 0 0 0 0 0 Q8NDA2 HMCN2_HUMAN Hemicentin-2 HMCN2 Homo sapiens (Human) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509] DDPLAEVGVK;GVPTPNITWFK;ITGVSNIDFR;LDFRLQQGAYR;VYSSGRHSVRITGVSNIDFR 5 1 0.9781 -2.0611 0 0 0 0 0 0 7.04024 10.4248 10.8323 10.5644 12.7077 0 Q8NDA8 MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) cytoplasm [GO:0005737] AMERVLSSR;LAHPYRAAVLR;LLTTCLFYFKSSWENVR;MDLEGGWELLR;SLVHLAQK 5 3.4 0.97452 -3.4699 0 0 0 7.20163 10.2447 0 0 0 0 0 8.63172 0 Q8NDA8 MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) cytoplasm [GO:0005737] AMERVLSSR;ITLMLPSAVTR;LAHPYRAAVLR 3 7.3 0.7954 0.015594 0 0 0 0 0 0 0 0 0 6.74268 0 0 Q8NDB2 BANK1_HUMAN B-cell scaffold protein with ankyrin repeats BANK1 Homo sapiens (Human) B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; MAPK cascade [GO:0000165]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of translational initiation [GO:0045947]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to bacterium [GO:0009617] perinuclear region of cytoplasm [GO:0048471] phospholipase binding [GO:0043274]; protease binding [GO:0002020]; protein tyrosine kinase binding [GO:1990782]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102] EFGFCCK;LLILSNSLLRDLTPKK;YYPTAKAKECLFR 3 4.6 0.89349 -0.22588 0 0 3.28294 7.61677 0 0 0 0 0 0 8.46606 0 Q8NDB6 FA156_HUMAN Protein FAM156A/FAM156B (Transmembrane protein 29/29B) FAM156A TMEM29 PP12994 PRO0659; FAM156B TMEM29B Homo sapiens (Human) membrane [GO:0016020]; nuclear envelope [GO:0005635] methylated histone binding [GO:0035064] TLEERRWER 1 4.2 0.8296 -0.023937 0 0 0 0 0 0 0 2.51473 0 0 8.42853 0 Q8NDC0 MISSL_HUMAN MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like) MAPK1IP1L C14orf32 Homo sapiens (Human) SDEFSLADALPEHSPAK 1 6.9 0 7.2438 0 0 0 0 0 0 9.40905 8.81375 0 7.77854 0 0 Q8NDD1 FSAF1_HUMAN 40S small subunit processome assembly factor 1 FSAF1 C1orf131 cPERP-A Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274] chromosome [GO:0005694]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] ILEQERAIMLGAKPPK 1 5.5 0.95117 -0.66925 0 0 0 0 8.42488 0 0 0 0 0 0 0 Q8NDF8 PAPD5_HUMAN Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) TENT4B GLD4 PAPD5 TRF4-2 TUT3 Homo sapiens (Human) carbohydrate homeostasis [GO:0033500]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA 3'-end processing [GO:0031124]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499] ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] DAPLSDLCR;HKRDAPLSDLCR;VGSQDVSLESSQAVGK;YPVLPYLVLVLKQFLLQR 4 6.6 0.96486 -1.1549 0 0 7.44832 12.0383 0 0 9.29742 0 10.91 0 0 0 Q8NDG6 TDRD9_HUMAN ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) TDRD9 C14orf75 Homo sapiens (Human) cell differentiation [GO:0030154]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; piP-body [GO:0071547] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] HIPPYGFLYYK;LNYIQIK;STQLPQYILDHYVQR;YPKDELNWGR 4 3.1 0.97872 -2.0953 0 0 0 0 10.3138 0 0 0 0 0 0 8.77663 Q8NDH2 CC168_HUMAN Leucine-rich repeat transmembrane protein CCDC168 (Coiled-coil domain-containing protein 168) CCDC168 C13orf40 Homo sapiens (Human) membrane [GO:0016020] ADPKTFALPK;AEALPLALLCNGK;CEQPIDDSLSSIEK;CILSNRTRR;DRTCILPQPK;EDGEGEEQGNR;EDGQSNDRISKMFSPK;EDREGEEQGKEDR;EEEGEPR;EKKSSISQIHK;EQSKLDITLKSNR;ESVVGDIPKDVKNEK;FCLSSSTQQELSDTMEK;HKSASKPHHDDINFYSERK;HQTDANTNINLEQKK;IEGREGR;IQDSSDSGK;ISKMFSPK;ITSSLTSEEK;IVRESYAMTSAHER;KPDLRIIEQEEK;KSLQMFNFYPK;LPISSGAGKSR;NTCESVDLR;SDLFRKNSSHWDHDYSCTHSK;SGPGVMLSKSPSR;STKQHISQGK;WDSSISEK;YTLSYLNDITGDSNR 29 4.8 0.97896 -13.191 14.2889 13.5303 0 8.3869 11.9281 9.18148 14.033 9.88463 13.7023 10.8173 10.5954 12.6263 Q8NDH3 PEPL1_HUMAN Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) NPEPL1 KIAA1974 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233] ELHGGNRGGYQPK;TTMPGMKR;VGKELGIIPTIIR 3 6.9 0.98065 -1.7497 0 0 0 5.97662 0 0 0 0 0 0 9.73486 0 Q8NDH6 ICA1L_HUMAN Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein) ICA1L ALS2CR14 ALS2CR15 Homo sapiens (Human) regulation of transport [GO:0051049] Golgi apparatus [GO:0005794] protein domain specific binding [GO:0019904] EFGAPQFSNSENVAK;ISEDNKDEQIGGFLTEQLNK;TEYRGALLWMK 3 9.5 0.9654 -1.1235 0 0 0 0 0 0 11.7211 0 0 0 0 0 Q8NDI1 EHBP1_HUMAN EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DPHAEEFEDK;DSTVRKTQLQSFSQYIENRPEMK;LGYSYSR;MNQLSLLEKEHDLERR;SDPESPIKKTSLSPTSK 5 5.9 0.95506 -0.87816 0 0 0 0 8.23998 0 0 0 0 9.557 9.37864 9.44133 Q8NDL9 CBPC5_HUMAN Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) AGBL5 CCP5 Homo sapiens (Human) C-terminal protein deglutamylation [GO:0035609]; defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] INIMNMNK;LGPGWAGAHR;LGPGWAGAHRR;SVNSIPAACHDNGR 4 4 0.97819 -1.5119 0 0 0 0 0 0 10.6545 0 9.83476 0 0 0 Q8NDM7 CFA43_HUMAN Cilia- and flagella-associated protein 43 (WD repeat-containing protein 96) CFAP43 C10orf79 WDR96 Homo sapiens (Human) brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; nucleus organization [GO:0006997]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576] EDILRMVIPQPAFMAKPDAVWTEEERK;FQLNLTIQILLK;TLVVQDEEITAHKHIKPWHK 3 3.5 0.81457 -0.0001722 8.1471 6.79831 0 0 7.91678 0 13.0896 0 0 0 0 0 Q8NDN9 RCBT1_HUMAN RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1) RCBTB1 CLLD7 E4.5 Homo sapiens (Human) chromatin organization [GO:0006325] cytoplasm [GO:0005737]; nucleus [GO:0005634] GITVENAFSLFSAAVR 1 3 0.55471 0.18291 0 0 0 0 0 8.24883 0 0 0 0 0 0 Q8NDP4 ZN439_HUMAN Zinc finger protein 439 ZNF439 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" THIGEKPYECQECGK 1 3 0.89258 -0.22307 0 11.2232 0 0 0 0 0 12.6971 0 0 0 0 Q8NDQ6 ZN540_HUMAN Zinc finger protein 540 ZNF540 Nbla10512 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDSDVKHDCK;KPYECKECGKSFNVR;LSFYLTEHRR 3 5.3 0.96445 -1.1732 0 0 8.30086 0 0 0 0 7.43546 0 0 0 0 Q8NDT2 RB15B_HUMAN Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RBM15B OTT3 Homo sapiens (Human) "dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA methylation [GO:0001510]; RNA splicing [GO:0008380]" nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EFDRFGSIR;LFHQFKR;QRSLSPVAAPPLR;RRSLSSDR;VDFAKAEETR;VIGRNPIKIGYGK 6 6.7 0.97675 -4.845 0 0 0 0 0 9.12102 10.4308 0 14.1908 8.75599 0 0 Q8NDV1 SIA7C_HUMAN "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.3.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)" ST6GALNAC3 SIAT7C UNQ2787/PRO7177 Homo sapiens (Human) ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082] Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]" RKSVIAVSFIAAFLFLLVVR;SVIAVSFIAAFLFLLVVR 2 9.5 0.13537 0.35567 0 0 0 6.61558 0 0 0 0 0 6.67342 6.96717 0 Q8NDV3 SMC1B_HUMAN Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B) SMC1B SMC1L2 Homo sapiens (Human) meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] EFENKHVK;EVGKLQKEVVSIQTSLEQK;NIAAERRQAK;RLYPDSVFGR;TAAPNLR;TDEERLAFEKR;VAKDCIR 7 5.8 0.97235 -2.7821 0 0 0 0 0 0 0 12.6236 12.9911 9.93397 0 10.9514 Q8NDV7 TNR6A_HUMAN Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) TNRC6A CAGH26 KIAA1460 TNRC6 Homo sapiens (Human) cellular response to starvation [GO:0009267]; endoderm development [GO:0007492]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442] protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] AQVPPPLLSPQVPVSLLK;HGAISSGFR;SSQGWSVSASDNWGETSR;TVGKGPGSRPQISK 4 3 0.96163 -1.0732 0 0 12.4115 0 0 0 0 0 0 7.90111 5.96798 0 Q8NDW4 ZN248_HUMAN Zinc finger protein 248 ZNF248 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SYDYNENGSNFSKK;SYKYDQK;TFIESLK 3 4.8 0.98024 -1.7166 0 0 0 0 5.07921 0 0 0 0 0 0 0 Q8NDW8 TT21A_HUMAN Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Stress-inducible protein 2) TTC21A STI2 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]; spermatid development [GO:0007286] cilium [GO:0005929]; intraciliary transport particle A [GO:0030991] AGDYPEAIK;IGHAYVK;LAKTPWVLSEAEDLEK;LLREFYPHSDSSQTQLRLLQGLCR 4 4.2 0.97537 -1.4468 0 0 0 0 0 0 0 10.5469 0 0 8.34891 0 Q8NDX1 PSD4_HUMAN PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) PSD4 EFA6B TIC Homo sapiens (Human) regulation of ARF protein signal transduction [GO:0032012] membrane [GO:0016020]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] ELEEHRLR;GRELEEHR 2 0.9 0.97497 -2.3763 0 0 0 0 0 9.63606 0 0 0 0 0 0 Q8NDX2 VGLU3_HUMAN Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) "cochlea development [GO:0090102]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; regulation of acetylcholine uptake [GO:0051631]; regulation of synapse structure or activity [GO:0050803]; sensory perception of sound [GO:0007605]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]" apical dendrite [GO:0097440]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; glial limiting end-foot [GO:0097451]; glutamatergic synapse [GO:0098978]; multivesicular body [GO:0005771]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; sodium:phosphate symporter activity [GO:0005436] AFDTFKEKILKPGK;QILTTTAVR 2 4.3 0.95388 -0.89377 0 0 0 0 0 0 0 12.6035 0 0 5.86814 0 Q8NDX5 PHC3_HUMAN Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) PHC3 EDR3 PH3 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] FALSRWNR;TTVTSSK;WNRKPDNQSLGHR 3 2.5 0.97476 -3.4661 11.8769 0 0 0 0 7.64263 10.3184 0 0 0 0 11.3188 Q8NDX5 PHC3_HUMAN Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) PHC3 EDR3 PH3 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] LLLKIVVLFIFLADR;LLLKIVVLFIFLADRAK;TTVTSSK 3 7.2 0.89764 -0.2553 4.36884 0 0 0 0 0 10.6329 0 0 0 0 4.14503 Q8NDX6 ZN740_HUMAN Zinc finger protein 740 (OriLyt TD-element-binding protein 7) ZNF740 TB7 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VVVVEQNGSFQVK 1 6.7 0.84778 -0.076925 0 0 11.8756 9.53759 0 0 0 0 0 0 0 0 Q8NDY3 ARHL1_HUMAN Inactive ADP-ribosyltransferase ARH2 (ADP-ribosylhydrolase-like protein 1) ([Protein ADP-ribosylarginine] hydrolase-like protein 1) ADPRHL1 ARH2 Homo sapiens (Human) cardiac chamber ballooning [GO:0003242]; cardiac myofibril assembly [GO:0055003]; protein de-ADP-ribosylation [GO:0051725] sarcomere [GO:0030017] ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287] EKFKAAMLLGSVGDALGYR 1 5.4 0.95752 -0.99957 0 0 0 0 0 0 0 11.5165 0 0 0 0 Q8NDZ0 BEND2_HUMAN BEN domain-containing protein 2 BEND2 CXorf20 Homo sapiens (Human) DNA binding [GO:0003677] DGGEGCSWMFQPMNNSK;DWKSCVTSINSGIR;NVRVLKIHLLAVQNMAKPK 3 6.3 0.92965 -0.48094 0 0 0 0 0 0 0 0 5.57398 0 9.87387 4.07468 Q8NDZ2 SIMC1_HUMAN SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation) SIMC1 C5orf25 PLEIAD Homo sapiens (Human) cytoplasm [GO:0005737]; PML body [GO:0016605]; sarcomere [GO:0030017] peptidase inhibitor activity [GO:0030414]; SUMO polymer binding [GO:0032184] TVDFIDLTRETRPR;VPWLSVMETPARK 2 3 0.89702 -0.24765 0 0 0 0 0 0 0 0 11.8102 0 0 10.6243 Q8NDZ4 DIK2A_HUMAN Divergent protein kinase domain 2A (Deleted in autism protein 1) (Golgi Protein of 49 kDa) (GoPro49) (Hypoxia and AKT-induced stem cell factor) (HASF) DIPK2A C3orf58 DIA1 Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein kinase C activity [GO:1900020]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] COPI vesicle coat [GO:0030126]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139] YGRFQAAKELR 1 2.6 0.87013 -0.094463 0 0 5.92958 0 0 0 0 0 0 0 0 0 Q8NE01 CNNM3_HUMAN Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) CNNM3 ACDP3 Homo sapiens (Human) magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811] membrane [GO:0016020]; plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] ERVLELARGGGDPYSDLSK;ESGSEAERAAARR;LAVLLTLPVALPVGQLLELAARPGRLRER;WTLALAPR 4 9.5 0.97826 -2.1008 0 0 0 8.17697 0 0 0 0 0 5.21506 9.43919 0 Q8NE09 RGS22_HUMAN Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) negative regulation of signal transduction [GO:0009968] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634] G-protein alpha-subunit binding [GO:0001965] DIDPFPQMATLLPLRPK;DPGRHQR;EAQMTIFGVLFKFWPQFCEFRK;ELLYPGSSKDDVIEK;FSDLLNNKLEFEHFR;FVALKGDLLENGLLFWQEVQK;LLDGSQWNEEHLR;QLDSTYFRK;YIEALEQERILLKIQEELEK 9 11 0.97939 -1.8989 0 0 6.32909 7.32975 0 0 11.4125 0 10.4264 9.03108 9.26758 0 Q8NE18 NSUN7_HUMAN Putative methyltransferase NSUN7 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 7) NSUN7 Homo sapiens (Human) RNA methylation [GO:0001510]; RNA processing [GO:0006396] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] EEKPKDDTPSSLLRPPRR;KALEFQDLGNKGQPYR;KEEKPKDDTPSSLLRPPR;LQKVKVILLLPR 4 6.5 0.15264 0.3491 8.50621 0 8.16143 6.82655 0 0 0 10.0612 9.51759 5.48726 0 0 Q8NE22 SETD9_HUMAN SET domain-containing protein 9 (EC 2.1.1.-) SETD9 C5orf35 Homo sapiens (Human) methylation [GO:0032259]; regulation of signal transduction by p53 class mediator [GO:1901796] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] lysine N-methyltransferase activity [GO:0016278] YQDLLAVEHQGVK;YRFVPWIALNLSHNPRTLR 2 10.7 0.7157 0.13803 0 0 0 8.49221 0 0 0 11.5208 0 11.0997 0 0 Q8NE28 STKL1_HUMAN Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071) STKLD1 C9orf96 SGK071 Homo sapiens (Human) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] IIDSEIKTEGVPNTR 1 6.7 0.91698 -0.42898 0 1.6653 0 0 0 0 0 0 0 0 7.78228 0 Q8NE31 FA13C_HUMAN Protein FAM13C FAM13C FAM13C1 Homo sapiens (Human) CSCGDGK;KPKSIFKAESGR;LLYHITDGDNPLLSPR;LRLLEVLISKQDVAK 4 8.5 0.97794 -2.1585 0 0 0 10.1404 0 9.44381 5.68142 0 0 3.8338 0 0 Q8NE35 CPEB3_HUMAN Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3) CPEB3 KIAA0940 Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; long-term memory [GO:0007616]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translation [GO:0045727]; regulation of dendritic spine development [GO:0060998]; regulation of synaptic plasticity [GO:0048167]" apical dendrite [GO:0097440]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] "mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; translation factor activity, RNA binding [GO:0008135]" LYLCVSSPTIK;RAVGVGVGVGVGVPSPLNPISPLK;TDHEPLK 3 6 0.95155 -0.69013 0 0 9.92794 0 0 6.24319 0 0 0 0 0 0 Q8NE62 CHDH_HUMAN "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" CHDH Homo sapiens (Human) choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660] ELQPGSHIQSDK 1 2 0.80577 0.011624 0 0 0 0 8.17313 0 0 0 0 0 0 0 Q8NE63 HIPK4_HUMAN Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) HIPK4 Homo sapiens (Human) regulation of signal transduction by p53 class mediator [GO:1901796] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EALAEHADLKSMVELIK 1 2.8 0.81215 -0.01284 0 0 0 0 0 0 0 0 0 10.076 0 0 Q8NE71 ABCF1_HUMAN ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) ABCF1 ABC50 Homo sapiens (Human) inflammatory response [GO:0006954]; positive regulation of translation [GO:0045727]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; translation factor activity, RNA binding [GO:0008135]" ATGAAAAEAKAR 1 1.4 0.98018 -1.5513 0 0 0 0 0 0 0 10.6886 0 0 0 0 Q8NE86 MCU_HUMAN "Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)" MCU C10orf42 CCDC109A Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; calcium-mediated signaling [GO:0019722]; cellular response to calcium ion starvation [GO:0072732]; glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein complex oligomerization [GO:0051259] calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292] LPSRRER;MAAAAGR 2 4 0.96185 -1.07 0 0 0 0 0 0 0 0 11.3658 0 0 0 Q8NEA4 FBX36_HUMAN F-box only protein 36 FBXO36 FBX36 Homo sapiens (Human) QLFFTNKLQLQRQLR 1 9.6 0.50704 0.1879 12.9182 0 0 0 0 0 0 0 0 0 0 0 Q8NEA5 CS018_HUMAN Uncharacterized protein C19orf18 C19orf18 Homo sapiens (Human) extracellular exosome [GO:0070062]; membrane [GO:0016020] LAQAEER 1 3.3 0.93553 -0.52885 14.9269 0 0 0 0 0 0 0 0 0 0 0 Q8NEA9 GMCL2_HUMAN Germ cell-less protein-like 2 (Germ cell-less protein-like 1-like) GMCL2 GCL GMCL1L GMCL1P1 Homo sapiens (Human) germ cell development [GO:0007281]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] nuclear matrix [GO:0016363]; nucleus [GO:0005634] cullin family protein binding [GO:0097602] EVGPQEINK;ICALGEEWR;LRLASFDSSGK;TTGYQILILK 4 7.4 0.96595 -1.2614 0 8.58376 0 0 8.42689 0 0 0 0 10.4199 14.3922 0 Q8NEB5 PLPP5_HUMAN Phospholipid phosphatase 5 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1B) PLPP5 DPPL1 HTPAP PPAPDC1B Homo sapiens (Human) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] diacylglycerol diphosphate phosphatase activity [GO:0000810]; phosphatidate phosphatase activity [GO:0008195] HHWQGPFKW 1 4.2 0.7824 0.026223 0 0 0 0 9.17794 0 0 0 0 0 0 0 Q8NEB7 ACRBP_HUMAN "Acrosin-binding protein (Acrosin-binding protein, 60 kDa form) (Cancer/testis antigen 23) (CT23) (Cancer/testis antigen OY-TES-1) (Proacrosin-binding protein sp32) [Cleaved into: Acrosin-binding protein, mature form (Acrosin-binding protein, 32 kDa form, mature form)]" ACRBP Homo sapiens (Human) acrosome assembly [GO:0001675]; fertilization [GO:0009566]; spermatid development [GO:0007286] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634] FYGLDLYGGLHMDFWCAR;SVCDSLGR;SVCDSLGRR;VREVESTPMIMENIQELIR 4 8.5 0.97884 -1.9194 0 0 8.65037 0 0 0 0 11.3046 10.9457 0 9.93195 0 Q8NEB9 PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) PIK3C3 VPS34 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein lipidation [GO:1903061]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to lysosome [GO:0006622]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; synaptic vesicle endocytosis [GO:0048488] "autolysosome [GO:0044754]; autophagosome [GO:0005776]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; postsynaptic endosome [GO:0098845]; presynaptic endosome [GO:0098830]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]; protein kinase activity [GO:0004672] FRYYLTNQEK 1 1.1 0.92154 -0.44666 0 0 0 0 0 5.87448 0 0 0 0 0 0 Q8NEC7 GSTCD_HUMAN Glutathione S-transferase C-terminal domain-containing protein GSTCD Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] ASFVTCPCCYGFIQNTSKFNFPK 1 3.6 0.92216 -0.44709 0 7.79786 0 0 0 0 0 0 0 0 0 0 Q8NEE0 KLAS1_HUMAN Putative uncharacterized protein KLHL30-AS1 (KLHL30 antisense RNA 1) KLHL30-AS1 C2orf19 Homo sapiens (Human) WGWHRGEPGHPR 1 14.6 0.92374 -0.44789 0 12.8299 0 0 0 0 0 0 0 0 0 0 Q8NEE6 FXL13_HUMAN F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13) FBXL13 DRC6 FBL13 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] centrosome [GO:0005813]; cytosol [GO:0005829]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005] TNENVVLAEKMNRAVTCYNFR 1 2.9 0.86439 -0.083824 0 0 0 0 0 0 0 0 0 0 6.26544 0 Q8NEE8 TTC16_HUMAN Tetratricopeptide repeat protein 16 (TPR repeat protein 16) TTC16 Homo sapiens (Human) INRAIENNPLDPSLFLFR;QEPSKTKTTR 2 3.2 0.9649 -1.2518 0 0 0 0 0 0 10.7715 0 0 0 0 0 Q8NEF3 CC112_HUMAN Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1) CCDC112 MBC1 Homo sapiens (Human) centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] FQERDLHKLELK;ILDRQAK 2 4.3 0.95944 -1.0437 0 0 0 0 0 0 0 0 3.24734 0 0 0 Q8NEF9 SRFB1_HUMAN Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) SRFBP1 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490] 90S preribosome [GO:0030686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723] AAVQAFK;AIARLAVHPLLKK;VLVIRKLVR 3 6.8 0.98088 -1.7772 0 0 0 3.0176 0 0 0 0 0 0 11.0737 0 Q8NEG0 GAR6_HUMAN Golgi-associated RAB2 interactor protein 6 GARIN6 FAM71C Homo sapiens (Human) GEYTIFRYAPMFESDFIQISK;LLPLMFVKITIHNSVKK 2 15.8 0.953 -0.73565 0 0 0 6.35741 0 0 0 0 0 0 0 12.9931 Q8NEG2 CG057_HUMAN Uncharacterized protein C7orf57 C7orf57 Homo sapiens (Human) AGTPLGPK;LSFPPVNGYK 2 11.8 0.9336 -0.49941 0 0 0 0 0 0 0 0 0 9.40593 0 0 Q8NEG4 FA83F_HUMAN Protein FAM83F FAM83F Homo sapiens (Human) signal transduction [GO:0007165] protein kinase binding [GO:0019901] AALEALLGGGEQAYRERLK;QLSLAGRVGLHYSSTVAR;VATGSYR;YALVSGCRHPPGEMMRWAAR;YFLEMCQDLQLTDFRIRNIR 5 16.8 0.98163 -1.7665 0 13.2664 0 0 0 7.35808 0 0 0 0 8.23271 0 Q8NEG5 ZSWM2_HUMAN E3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) ZSWIM2 ZZZ2 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LVAAAEK;YLQDLPTVSFGK 2 3 0.94712 -0.66252 0 0 0 0 0 0 0 0 0 0 7.70203 0 Q8NEG7 DEN6B_HUMAN Protein DENND6B (DENN domain-containing protein 6B) DENND6B FAM116B Homo sapiens (Human) cytosol [GO:0005829]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] APVALQREPAHYFGYVYFRQVK;ARGCLGAAGPTSSGR;DALLGTGPR;DLQAVLCPP;MSGDLPK 5 10.6 0.98136 -1.7064 0 0 0 0 0 0 10.3687 0 0 11.8988 8.93987 11.4693 Q8NEH6 MNS1_HUMAN Meiosis-specific nuclear structural protein 1 MNS1 Homo sapiens (Human) cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; left/right axis specification [GO:0070986]; meiotic cell cycle [GO:0051321]; positive regulation of cilium assembly [GO:0045724]; sperm axoneme assembly [GO:0007288] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; intermediate filament [GO:0005882]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; sperm flagellum [GO:0036126] identical protein binding [GO:0042802] DAIKYEQMK;DAIKYEQMKR;IIKEENAAEDKR;LAMELAK;QQFLADKQRELEEWQLQQR;YIEEFQKEQALWRK 6 12.5 0.96258 -1.1028 0 0 0 8.35072 0 0 0 11.0556 8.7962 0 6.93251 0 Q8NEJ9 NGDN_HUMAN Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) NGDN C14orf120 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of protein localization to plasma membrane [GO:1903077]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of translation at postsynapse [GO:0140245]; ribosomal small subunit biogenesis [GO:0042274]" "axon [GO:0030424]; chromosome, centromeric region [GO:0000775]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynapse [GO:0098794]; small-subunit processome [GO:0032040]" RNA binding [GO:0003723] ELKEQYSDAPEEIRDAR;LVPVHYDETEAER;QSQEDQHRINYEESMMVR 3 15.2 0.9665 -1.2634 6.82184 0 0 5.75633 0 0 0 9.6206 0 9.23067 0 0 Q8NEK5 ZN548_HUMAN Zinc finger protein 548 ZNF548 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FFRYISTLIR;FFRYISTLIRHQR;NHTGERPYK;SFMYNYRLMRHK 4 6.4 0.95559 -0.94251 8.28212 0 0 0 0 0 0 0 10.5316 5.3438 10.9435 0 Q8NEK8 TET5D_HUMAN Terminal nucleotidyltransferase 5D (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46D) TENT5D FAM46D Homo sapiens (Human) mRNA stabilization [GO:0048255] poly(A) RNA polymerase activity [GO:1990817] DIIHVVK;FFIDFPHIEEQQK;GNFPTMEVKPKDIIHVVK 3 8 0.92097 -0.44632 0 0 0 10.3772 0 0 0 0 6.59954 0 0 0 Q8NEL0 CCD54_HUMAN Coiled-coil domain-containing protein 54 (Testis development protein NYD-SP17) CCDC54 Homo sapiens (Human) NVYHKCKIR 1 2.7 0.97502 -1.3915 0 0 0 0 0 0 0 0 0 10.4573 0 0 Q8NEL9 DDHD1_HUMAN Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) DDHD1 KIAA1705 Homo sapiens (Human) phosphatidylinositol metabolic process [GO:0046488]; positive regulation of mitochondrial fission [GO:0090141] cytoplasm [GO:0005737]; cytosol [GO:0005829] metal ion binding [GO:0046872]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620] ASSMTQTPALK;EIEERLHGLK;GLGGMLFSR 3 3.3 0.97674 -2.2081 0 0 0 0 0 0 0 10.7421 0 7.96774 0 0 Q8NEM1 ZN680_HUMAN Zinc finger protein 680 ZNF680 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ISCKSVDESK;VIHTGEK 2 3.2 0.92087 -0.44634 0 0 0 0 0 0 0 0 0 0 0 7.57977 Q8NEM2 SHCBP_HUMAN SHC SH2 domain-binding protein 1 SHCBP1 Homo sapiens (Human) fibroblast growth factor receptor signaling pathway [GO:0008543]; regulation of neural precursor cell proliferation [GO:2000177] cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle [GO:0005819] SH2 domain binding [GO:0042169] EGILIKDFLDEHYDIPK;TFFPEIFQTNQLLFYER;VLEPSGWR 3 6.2 0.64684 0.17083 0 0 9.77156 0 0 9.26217 0 0 0 0 0 0 Q8NEM7 SP20H_HUMAN Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) SUPT20H C13orf19 FAM48A FP757 Homo sapiens (Human) autophagy [GO:0006914]; gastrulation [GO:0007369]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] transcription coregulator activity [GO:0003712] AGQHYDLK;EPEVKKLR;ISKAGNCVDMWKR 3 3.7 0.93701 -0.52657 9.70567 0 0 9.13935 0 0 0 0 0 0 0 0 Q8NEM8 CBPC3_HUMAN Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) (Protein deglutamylase CCP3) AGBL3 CCP3 Homo sapiens (Human) protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] EGTGRVVMWKMGIR;EVILYCDLHGHSR;MSEDSEKEDYSDRTISDEDESDEDMFMK;VTSLQSPMGK;VVMWKMGIR 5 6.5 0.98112 -1.7016 0 0 0 5.68558 0 5.39948 10.5114 10.8311 0 0 0 11.6998 Q8NEN0 ARMC2_HUMAN Armadillo repeat-containing protein 2 ARMC2 Homo sapiens (Human) cell morphogenesis [GO:0000902]; cilium organization [GO:0044782]; nucleus organization [GO:0006997]; sperm axoneme assembly [GO:0007288] ALLPDRSLPPSDSKK;GDKDVCTNIAR;LAKIILALK;LAKIILALKVSR;SHPLQLTDDGGFSEIK 5 6.2 0.97429 -2.4457 0 0 0 0 0 0 0 4.58159 12.5673 0 0 10.0519 Q8NEN9 PDZD8_HUMAN PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) PDZD8 PDZK8 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; lipid transport [GO:0006869]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; regulation of cell morphogenesis [GO:0022604] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; metal ion binding [GO:0046872] DLYRGLPTEERIQK;HIINTSSRLLNLR;HTLPNYKIR;LIAIGGVKITSTLQVLKLIK;SAEKQAK 5 5.5 0.97528 -3.298 0 0 0 0 3.69131 0 0 0 9.7287 8.11608 10.0962 9.23338 Q8NEP3 DAAF1_HUMAN Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50) DNAAF1 LRRC50 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; left/right pattern formation [GO:0060972]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] dynein complex binding [GO:0070840] EEPPGDR;VLNLMGNPVIRQIPNYR 2 3.3 0.93399 -0.50426 0 0 0 0 0 0 0 0 0 0 8.8031 8.28656 Q8NEP3 DAAF1_HUMAN Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50) DNAAF1 LRRC50 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; left/right pattern formation [GO:0060972]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] dynein complex binding [GO:0070840] EEPPGDR;GNPVIRQIPNYRR 2 4.1 0.86786 -0.093777 0 0 0 0 0 7.67009 0 0 0 0 0 0 Q8NEP9 ZN555_HUMAN Zinc finger protein 555 ZNF555 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ECGEAFSYSSAFRRHMITHTGEKPYECK;QCGKTFIYLQSFR 2 6.5 0.97306 -2.5945 9.21483 0 0 0 0 0 0 0 0 0 0 11.0825 Q8NER1 TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) TRPV1 VR1 Homo sapiens (Human) behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to acidic pH [GO:0071468]; cellular response to alkaloid [GO:0071312]; cellular response to ATP [GO:0071318]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to temperature stimulus [GO:0071502]; cellular response to tumor necrosis factor [GO:0071356]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; diet induced thermogenesis [GO:0002024]; fever generation [GO:0001660]; glutamate secretion [GO:0014047]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of heart rate [GO:0010459]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide secretion [GO:0002790]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein homotetramerization [GO:0051289]; response to capsazepine [GO:1901594]; response to peptide hormone [GO:0043434]; sensory perception of mechanical stimulus [GO:0050954]; sensory perception of taste [GO:0050909]; smooth muscle contraction involved in micturition [GO:0060083]; thermoception [GO:0050955] dendritic spine membrane [GO:0032591]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; chloride channel regulator activity [GO:0017081]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphoprotein binding [GO:0051219]; temperature-gated ion channel activity [GO:0097603]; transmembrane signaling receptor activity [GO:0004888]; voltage-gated calcium channel activity [GO:0005245] EASARDR;ITARIWRACCSSCR;LEELTNK;NDSLPSESTSHR 4 4.8 0.94598 -0.65113 10.1973 6.2806 0 0 5.35702 0 0 0 0 0 0 7.86481 Q8NET5 NFAM1_HUMAN NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1) NFAM1 CNAIP Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of cytokine production [GO:0001819]; regulation of B cell differentiation [GO:0045577]; signal transduction [GO:0007165] azurophil granule membrane [GO:0035577]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] WRALPGLPRPPGLPAAPWLLLGVLLLPGTLR 1 11.5 0.83937 -0.039446 0 0 0 0 0 0 0 5.23661 0 0 0 0 Q8NET6 CHSTD_HUMAN Carbohydrate sulfotransferase 13 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 3) (Chondroitin 4-sulfotransferase 3) (C4ST-3) (C4ST3) CHST13 Homo sapiens (Human) carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139]; membrane [GO:0016020] chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146] DISPFYQRR;HVLVDDAHGLLYCYVPK;MGRRCCR 3 9.7 0.97633 -2.2872 0 0 0 8.98439 0 0 0 0 0 0 9.18421 0 Q8NET8 TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to temperature stimulus [GO:0009266] cytoplasm [GO:0005737]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; sodium channel activity [GO:0005272] TILEFEKMLPEWLR;VILHDVLKFLFVYIVFLLGFGVALASLIEK 2 5.6 0.95505 -0.81949 0 0 0 0 0 6.66263 0 0 0 0 0 0 Q8NEU8 DP13B_HUMAN "DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)" APPL2 DIP13B Homo sapiens (Human) "adiponectin-activated signaling pathway [GO:0033211]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1900077]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of D-glucose import [GO:0046325]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of phagocytosis, engulfment [GO:0060100]; protein homotetramerization [GO:0051289]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]" cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] AGYLNLR;FLGSMAVKTDSTTEVIYEAMR;QNFALGK 3 5.3 0.91471 -0.33635 10.7156 10.6252 10.5373 0 0 8.29343 12.5032 12.1652 0 0 0 0 Q8NEV4 MYO3A_HUMAN Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; regulation of actin filament length [GO:0030832]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; ADP binding [GO:0043531]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; calmodulin binding [GO:0005516]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microfilament motor activity [GO:0000146]; plus-end directed microfilament motor activity [GO:0060002]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] APICSQEEGRGRLR;CYSRDQIYVYVGDILIALNPFQSLGLYSTKHSK;FYGIYFK;LSEEYFILQKK;NFHIFYYIYAGLAEK;NFHIFYYIYAGLAEKK;QPELWSAEFNDFISKCLTKDYEK;SQYELIEQCFK;TGNLPHSKTK;TSTFKPEEETTNAVESNNR;VNGDKLWLVLELCSGGSVTDLVK 11 10.3 0.98054 -1.8007 0 4.96338 0 0 9.61666 6.58859 0 3.39767 11.699 8.7863 9.50488 11.3659 Q8NEV8 EXPH5_HUMAN Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) EXPH5 KIAA0624 SLAC2B Homo sapiens (Human) intracellular protein transport [GO:0006886]; keratinocyte development [GO:0003334]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714] endosome [GO:0005768] small GTPase binding [GO:0031267] CHSHSPFRNER;ENFQEYTEKEGKMAASR;GAAVQAK;ILQVLER;TTSTFSVSGDEDNVK 5 2.9 0.97828 -2.0783 0 0 9.78674 0 14.2567 0 0 0 8.60285 0 0 10.2905 Q8NEW7 TMIE_HUMAN Transmembrane inner ear expressed protein TMIE Homo sapiens (Human) inner ear morphogenesis [GO:0042472]; sensory perception of sound [GO:0007605] membrane [GO:0016020] KAAKMYTDK 1 5.8 0.97597 -1.4703 0 0 0 0 0 0 8.86709 0 0 0 0 0 Q8NEY1 NAV1_HUMAN Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 Homo sapiens (Human) microtubule bundle formation [GO:0001578]; neuron migration [GO:0001764] axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] ATP hydrolysis activity [GO:0016887] AAAADGRGMLPK;AAWEDPVEWVR;EAPLMSK;GREAPLMSKTLSK;KAAAADGRGMLPK;LVLSGPSGTGK;MEPGTSKWRR;SVSSLSNR 8 3.5 0.97416 -3.8031 13.397 10.8697 0 0 0 0 0 10.1012 11.9211 0 10.013 0 Q8NEY3 SPAT4_HUMAN Spermatogenesis-associated protein 4 (Testis and spermatogenesis cell-related protein 2) (Testis spermatocyte apoptosis-related gene 2 protein) SPATA4 TSARG2 Homo sapiens (Human) regulation of cytoskeleton organization [GO:0051493] axoneme [GO:0005930]; nucleus [GO:0005634] microtubule binding [GO:0008017] AGVPEILIEEVYTLLTHREIK;ELIHGTIHCK;LDNWAQLEKFLARK 3 14.8 0.89757 -0.23947 0 0 0 0 7.6014 0 13.6521 0 0 0 8.25659 0 Q8NEY8 PPHLN_HUMAN Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) PPHLN1 HSPC206 HSPC232 Homo sapiens (Human) "constitutive heterochromatin formation [GO:0140719]; keratinization [GO:0031424]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; protein localization to heterochromatin [GO:0097355]" chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ILLRTQTPFTPENLFLAMLSVVHCNSRK;SYSPERSK;YEYERIPR 3 9.6 0.97254 -2.8116 6.90014 6.92232 0 0 0 0 0 0 0 0 0 0 Q8NEZ3 WDR19_HUMAN WD repeat-containing protein 19 (Intraflagellar transport 144 homolog) WDR19 IFT144 KIAA1638 Homo sapiens (Human) cell morphogenesis [GO:0000902]; cilium assembly [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary retrograde transport [GO:0035721]; myotome development [GO:0061055]; nervous system process [GO:0050877]; protein localization to ciliary membrane [GO:1903441]; protein-containing complex assembly [GO:0065003]; receptor clustering [GO:0043113]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] FSDAWEMCR;HLAPDQIPFISK;RDLQHWDSALQLAK;TSQLDNGMR 4 3.3 0.95202 -0.69434 5.63497 0 11.676 0 0 0 0 0 0 0 11.0426 0 Q8NEZ4 KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to electrical stimulus [GO:0051602] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acyltransferase activity [GO:0016746]; DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] AGREFPEEDAEQLKHVTEQQSMVQK;AVHGGFEDCRPLNK;CLECTVCEACGK;DIDDNSNGTYEK;EEYICMYCKHLGAEMDR;EIFKPRQLPGSAIWSIK;GAGLSGRGGRGR;GVWDKILEPVACVR;IAESLPGVEACENYTFRYGR;IPELGGK;ISEGFTR;LGTSLKPDPVPKDYR;LQGEKEQK;LSMETPAKTEEIK;QFRITPGFILPWR;YANRRCR;YLEEQIGAHR 17 4.5 0.97847 -8.9102 11.689 11.2234 12.3454 7.66541 0 9.69009 12.3141 9.11533 6.82184 10.4758 0 10.8223 Q8NEZ5 FBX22_HUMAN F-box only protein 22 (F-box protein FBX22p44) FBXO22 FBX22 Homo sapiens (Human) cellular response to starvation [GO:0009267]; nucleocytoplasmic transport [GO:0006913]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; regulation of skeletal muscle fiber development [GO:0048742]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleus [GO:0005634]; Z disc [GO:0030018] ubiquitin-protein transferase activity [GO:0004842] VACVCRLWRECVR 1 3.2 0.86851 -0.093926 0 0 0 0 0 0 0 5.38142 0 0 0 0 Q8NF37 PCAT1_HUMAN Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) LPCAT1 AYTL2 PFAAP3 Homo sapiens (Human) negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0047159] MRLRGCGPR 1 1.7 0.97605 -1.4703 0 0 0 0 0 9.88136 0 0 0 0 0 0 Q8NF50 DOCK8_HUMAN Dedicator of cytokinesis protein 8 DOCK8 Homo sapiens (Human) cellular response to chemokine [GO:1990869]; dendritic cell migration [GO:0036336]; immunological synapse formation [GO:0001771]; memory T cell proliferation [GO:0061485]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of GTPase activity [GO:0043547]; positive regulation of T cell migration [GO:2000406]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ILVKLLTLK;LEPLVLFLHLVLDK;MATLPSAER;MFGTYFR;NTVLTTMHAFPYIK;RTRFSDR;SLQPDKR;TSAAAVSSK 8 3.6 0.9762 -2.3421 0 8.57667 0 8.09429 11.2126 8.02984 9.34895 8.84962 8.05045 7.1178 7.63147 0 Q8NF91 SYNE1_HUMAN Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] ALQEQAR;AREEVIELMNDTEKK;ATLDTALSPPK;ATLSRSMTTVWQR;DKTTMLGK;DLSTYSGKVSGLIK;DSYSAICSTAQR;EHMTLEKGLHLAKEFSDK;ELEQELAEQK;FLSFSSLESLSSELEQTKEFSKR;FSRDLSTYSGKVSGLIK;GDPEELLRRHTEFFSQLDQR;IMNALSHK;KEESPEHK;LAKDLTTILTKLK;LNELGYRLPLNDKEIK;LPVRDPVR;LSQMNGRWDR;LTELHQQTIRQAENRLSK;NKMNYKQK;NLDRRWR;QNIEKMAEEQKEK;TLEVLLKDMEK;VHVIGNRLKLLLK;WERFETNKETVVR 25 3.4 0.97891 -13.263 8.74153 4.09441 14.7607 10.9907 9.02799 9.66174 10.456 9.03463 13.8489 0 6.80516 11.1652 Q8NF91 SYNE1_HUMAN Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] DLSTYSGKVSGLIK;FSRDLSTYSGKVSGLIK;IPESSDPGCFPKNK;LEVCIFTQK 4 8.4 0.97635 -2.1851 0 0 0 0 0 0 0 10.4967 0 0 0 0 Q8NF91 SYNE1_HUMAN Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] ATLDTALSPPK;ELEQELAEQK;LNELGYRLPLNDKEIK;LSQMNGRWDR;NLDRRWR;TEKLQYLTSVYCTEK;VHVIGNRLKLLLK 7 2.6 0.91544 -0.43392 0 0 0 0 0 0 0 0 0 0 0 8.03645 Q8NF99 ZN397_HUMAN Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) ZNF397 ZNF47 ZSCAN15 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EGISEEK 1 1.3 0.94098 -0.58797 0 0 0 0 0 0 0 8.2006 0 0 0 0 Q8NFA0 UBP32_HUMAN Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843] EEMERMLHVVDGKVPDTLR;GLHFNNLIVGLVLLTR;LDGTTPVR;LDLWRLPPILIIHLK;LDLWRLPPILIIHLKR;LPPILIIHLK;MADTSSMDEDFESDYK;NPNCKWYCYNDSSCK;WYCYNDSSCK 9 5.6 0.95815 -1.0125 0 0 4.62726 7.52646 6.81826 0 8.66167 0 9.42181 4.85937 5.99404 0 Q8NFA2 NOXO1_HUMAN NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) NOXO1 P41NOX SH3PXD5 Homo sapiens (Human) extracellular matrix disassembly [GO:0022617]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554] cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phospholipid binding [GO:0005543]; superoxide-generating NADPH oxidase activator activity [GO:0016176] RALERRPR;VLPKLLDAPLLGRVGR 2 6.5 0.74607 0.093384 0 0 0 9.18344 0 0 0 0 6.45455 0 0 0 Q8NFC6 BD1L1_HUMAN Biorientation of chromosomes in cell division protein 1-like 1 BOD1L1 BOD1L FAM44A KIAA1327 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188] ATAPAYKPGR;EGTNVPLVAAGPCDDEGIVTSTGAK;ESYDPDVIPLFDKR;EVESLKLPSEKNSNK;NESKLEREHK;NTEENDSEK;QSIAKEKEER;STTRSEAQRSK;YPVETTLKMK 9 3.7 0.97474 -3.7557 13.6907 8.77568 8.41117 0 9.53733 9.44727 14.8724 0 0 14.5938 14.7716 15.0745 Q8NFD2 ANKK1_HUMAN Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) cellular response to retinoic acid [GO:0071300]; regulation of cell cycle process [GO:0010564] cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ISDFGLSKWMEQSTR;NLRTPLHLAVERGK;QPLGIVMEFMANGSLEKVLSTHSLCWK;VAVPESK 4 8.2 0.95347 -0.89241 7.62958 0 0 0 0 0 0 0 0 0 7.06964 7.65557 Q8NFD5 ARI1B_HUMAN AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) ARID1B BAF250B DAN15 KIAA1235 OSA2 Homo sapiens (Human) cellular response to angiotensin [GO:1904385]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; cytosol [GO:0005829]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] ALLAMARVDENR;EEEDAECIDDDEEDEEDEEEDSEK;SLSFVPGNDAEMSK 3 2.2 0.96442 -1.1645 0 0 0 0 0 7.0517 6.75836 0 0 0 0 0 Q8NFF5 FAD1_HUMAN FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] FLAD1 PP591 Homo sapiens (Human) FAD biosynthetic process [GO:0006747]; riboflavin metabolic process [GO:0006771] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; identical protein binding [GO:0042802] GWDLGTRLFQR 1 1.9 0.95156 -0.70343 0 0 0 0 0 9.84612 0 0 0 0 0 0 Q8NFH3 NUP43_HUMAN Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) NUP43 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] EAVRTIDNADSSTLHAVTFLR;INLFRADHK 2 7.9 0.97954 -1.8426 0 0 0 0 7.36763 0 0 0 0 0 0 10.8722 Q8NFH4 NUP37_HUMAN Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) NUP37 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IRLFTSDLQDKNEYK;TLRTFHHGVRVDGIAWSPETR 2 11 0.95631 -0.85107 0 0 0 0 0 9.87164 0 0 0 0 0 8.98345 Q8NFH5 NUP35_HUMAN Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) NUP35 MP44 NUP53 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056] ALSKDGR;SISGPSVGVMEMR 2 6.1 0.89594 -0.24183 9.25835 0 2.55464 0 0 0 0 10.0179 0 0 0 0 Q8NFI3 ENASE_HUMAN Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) ENGASE Homo sapiens (Human) N-glycan processing [GO:0006491]; protein folding [GO:0006457] cytosol [GO:0005829] mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925] SYQAVADR 1 1.1 0.9151 -0.39033 0 0 9.47871 0 0 0 0 0 0 0 0 0 Q8NFI4 F10A5_HUMAN Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) ST13P5 FAM10A5 Homo sapiens (Human) cytoplasm [GO:0005737] protein dimerization activity [GO:0046983] AIDLFTDAIK;AIEINPDSAQPYK;IAEHWRK;LAILYAK;QDPSVLHTEEMRFLR 5 14.1 0.90975 -0.31809 0 0 0 0 0 0 11.0775 0 0 0 0 0 Q8NFJ5 RAI3_HUMAN Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) GPRC5A GPCR5A RAI3 RAIG1 Homo sapiens (Human) negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; signal transduction [GO:0007165] cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982] cadherin binding [GO:0045296]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295] TNVNVFSELSAPR 1 3.6 0 1.8586 0 0 0 0 0 0 0 0 11.5765 0 0 0 Q8NFJ8 BHE22_HUMAN Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Trinucleotide repeat-containing gene 20 protein) BHLHE22 BHLHB5 TNRC20 Homo sapiens (Human) axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" SLSASTSK 1 2.1 0.91746 -0.42491 0 0 0 0 9.90682 10.1864 0 0 0 0 0 0 Q8NFK1 CXG3_HUMAN Gap junction gamma-3 protein (Connexin-30.2) (Cx30.2) (Connexin-31.3) (Cx31.3) (Gap junction epsilon-1 protein) GJC3 GJE1 Homo sapiens (Human) cell-cell signaling [GO:0007267]; myelination [GO:0042552]; sensory perception of sound [GO:0007605] connexin complex [GO:0005922]; myelin sheath [GO:0043209] gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802] MCGRFLR 1 2.5 0.98035 -1.6398 0 0 0 0 0 0 0 0 0 8.47881 0 0 Q8NFM4 ADCY4_HUMAN Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) ADCY4 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080] AATGVDINMR;AEEEDEKGTAGGLLSSLEGLK;ELTSDPSFLTTVLCALGGFSLLLGLASR;MESTGVLGK;QNEYYCRLDFLWKK;QSKDFNPLTLYFR 6 8.8 0.97428 -3.625 0 8.38939 0 9.07502 0 8.32026 0 10.9109 7.73789 10.5187 8.49773 0 Q8NFM7 I17RD_HUMAN Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef) IL17RD IL17RLM SEF UNQ6115/PRO20026 Homo sapiens (Human) negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] AVAITVPLVVISAFATLFTVMCRKK;FETDYFVK;GSGKGELFLVAVSAIAEK;IHESQFIIVVCSK 4 8.7 0.80854 0.0066318 0 0 0 6.4245 0 0 10.2091 0 7.56354 8.20467 0 0 Q8NFP0 PXT1_HUMAN Peroxisomal testis-specific protein 1 (Small testis-specific peroxisomal protein) PXT1 STEPP Homo sapiens (Human) positive regulation of apoptotic process [GO:0043065] nucleus [GO:0005634]; peroxisome [GO:0005777] HIGDNIDHRMVREDLQQDGR;VTHCCKSLWLK 2 23.1 0.95323 -0.67813 0 0 0 0 0 0 0 9.65537 0 0 6.80813 0 Q8NFP4 MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) brain development [GO:0007420]; cerebral cortex radially oriented cell migration [GO:0021799]; inhibitory synapse assembly [GO:1904862]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; presynapse assembly [GO:0099054]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; spinal cord association neuron differentiation [GO:0021527] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] VTYQWFKNGKPARMSK 1 1.7 0.45264 0.19145 0 0 7.98914 0 0 0 0 0 0 0 0 0 Q8NFP9 NBEA_HUMAN Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) NBEA BCL8B KIAA1544 LYST2 Homo sapiens (Human) protein localization [GO:0008104] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] protein kinase binding [GO:0019901] EIISLRAFMLLFLKQLILK;GESGIWPR;ITEMVYNIFR;TFSSVAR;YDFQPRK 5 1.7 0.97882 -2.0519 0 7.61648 0 0 0 0 6.73308 9.32373 0 8.61548 0 0 Q8NFQ6 BPIFC_HUMAN BPI fold-containing family C protein (Bactericidal/permeability-increasing protein-like 2) (BPI-like 2) BPIFC BPIL2 Homo sapiens (Human) innate immune response [GO:0045087] extracellular space [GO:0005615] lipopolysaccharide binding [GO:0001530]; phospholipid binding [GO:0005543] LVCSLSLNR;MIEQMLKEK 2 3.6 0.97694 -2.2392 0 0 0 0 0 10.5532 0 0 0 0 0 0 Q8NFR7 CC148_HUMAN Coiled-coil domain-containing protein 148 CCDC148 Homo sapiens (Human) AKVRQWR;DLQRLEELK;FAIEQQNILISNWNKNK;IENDLSDWSIK;ILDHSLEEK;ISPQKPPRK;NIKYKPVDYQQLR;TLYAKEILPKISPQKPPR;TLYLDMLQRYFPHK;VLEEVDFVK 10 18.3 0.97602 -5.2858 0 10.8836 0 10.1495 8.67349 9.94787 11.572 14.5151 0 0 0 10.8744 Q8NFR7 CC148_HUMAN Coiled-coil domain-containing protein 148 CCDC148 Homo sapiens (Human) AKVRQWR;FAIEQQNILISNWNKNK;IENDLSDWSIK;ILDHSLEEK;MNVFVTLQILVDFVK;TLYLDMLQRYFPHK 6 26.6 0.78196 0.03204 0 9.9656 0 0 0 0 0 0 0 0 0 0 Q8NFR9 I17RE_HUMAN Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE) IL17RE UNQ3056/PRO9877 Homo sapiens (Human) inflammatory response [GO:0006954] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] GLFHLLVQKSK;LGARQRR;LLRDLPR 3 3.7 0.97919 -1.9023 0 0 0 0 8.79756 0 0 0 0 0 0 12.752 Q8NFT2 STEA2_HUMAN Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203 Homo sapiens (Human) copper ion import [GO:0015677]; copper ion import across plasma membrane [GO:0098705]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; iron ion import across plasma membrane [GO:0098711]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725] cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140] cupric reductase (NADH) activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872] IKKGWEK;SQFLEEGMGGTIPHVSPER 2 5.3 0.8753 -0.12055 0 0 0 0 10.1445 0 0 0 0 0 10.4553 0 Q8NFT6 DBF4B_HUMAN Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1) DBF4B ASKL1 DRF1 Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987] cytoplasm [GO:0005737]; Dbf4-dependent protein kinase complex [GO:0031431]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleic acid binding [GO:0003676]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270] ELLLRVPK 1 1.6 0.91303 -0.33804 0 0 0 6.78895 0 0 0 0 0 0 0 0 Q8NFU0 BEST4_HUMAN Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) BEST4 VMD2L2 Homo sapiens (Human) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872] YANLASVLVLRSVSTRVLK 1 4 0.86437 -0.08394 0 0 0 0 0 0 0 0 0 0 8.30122 7.0797 Q8NFU1 BEST2_HUMAN Bestrophin-2a (Vitelliform macular dystrophy 2-like protein 1) BEST2 VMD2L1 Homo sapiens (Human) membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608] basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; cilium [GO:0005929]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly ligand-gated monoatomic ion channel activity [GO:0005217]; ligand-gated monoatomic anion channel activity [GO:0099095]; ligand-gated monoatomic cation channel activity [GO:0099094]; metal ion binding [GO:0046872] FPTIDHVVEAGFMTREER;MTVTYTARVANAR 2 6.1 0.96326 -1.0895 0 0 0 0 0 0 0 0 0 7.64703 8.92964 0 Q8NFU3 TSTD1_HUMAN Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.3) TSTD1 KAT Homo sapiens (Human) "sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] thiosulfate-thiol sulfurtransferase activity [GO:0050337] LEDEHLVFFCQMGKR 1 13 0.25605 0.26977 0 10.9982 0 0 0 0 0 0 0 0 0 0 Q8NFU5 IPMK_HUMAN "Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)" IPMK IMPK Homo sapiens (Human) inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; phosphatidylinositol metabolic process [GO:0046488] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; ATP binding [GO:0005524]; flavonoid binding [GO:0097243]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity [GO:0102732]; inositol-1,3,4,5-tetrakisphosphate 6-kinase activity [GO:0000825]; inositol-1,3,4,6-tetrakisphosphate 5-kinase activity [GO:0047326]; inositol-1,4,5,6-tetrakisphosphate 3-kinase activity [GO:0000824]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol-1,4,5-trisphosphate 6-kinase activity [GO:0000823]; metal ion binding [GO:0046872]" ILQWFENQK;LRFLNGCVPLSHQVAGHMYGKDK;SLTKETIK 3 9.6 0.97792 -1.5061 0 0 0 4.88981 0 0 0 11.6237 0 0 0 0 Q8NFU7 TET1_HUMAN Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) TET1 CXXC6 KIAA1676 LCX Homo sapiens (Human) "cellular response to reactive oxygen species [GO:0034614]; chromatin remodeling [GO:0006338]; chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; dendrite morphogenesis [GO:0048813]; epigenetic programing of male pronucleus [GO:0044727]; inner cell mass cell differentiation [GO:0001826]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]" nucleus [GO:0005634]; Sin3-type complex [GO:0070822] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; iron ion binding [GO:0005506]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CGVCEPCQQKTNCGECTYCK;INYIKPEDK;KNSHQICKK;LKQLIQERDVK;LSDSYLDPIK;NLNKPQHGFELNKIKFEAK;RCTLNENR;SEKDEESEQR;TCFTQPVPRSGK 9 5.1 0.97614 -5.047 13.8282 0 0 0 0 12.5542 8.30574 0 4.86711 0 10.0051 0 Q8NFW1 COMA1_HUMAN Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] RLYDSVPIDFDLQRIVIYCDSR 1 1.4 0.86511 -0.087715 0 0 0 0 0 0 0 12.9074 0 0 0 0 Q8NFW5 DMBX1_HUMAN Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1) DMBX1 MBX OTX3 PAXB Homo sapiens (Human) adult feeding behavior [GO:0008343]; adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; central nervous system development [GO:0007417]; developmental growth [GO:0048589]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GLGCKRGSPK;LAMCTNLPEARVQVWFK;SRTAFTAQQLEALEKTFQK;TFQKTHYPDVVMR 4 14.4 0.95528 -0.81549 6.38969 0 0 0 0 0 0 6.52504 0 0 0 10.6715 Q8NFW8 NEUA_HUMAN N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) CMAS Homo sapiens (Human) CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]; N-acetylneuraminate metabolic process [GO:0006054] membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] N-acylneuraminate cytidylyltransferase activity [GO:0008781] AVGYICK;LISERACSK 2 3.7 0.97836 -1.9423 0 0 0 0 0 0 0 0 0 9.22632 0 0 Q8NFW9 MYRIP_HUMAN Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) MYRIP SLAC2C Homo sapiens (Human) intracellular protein transport [GO:0006886]; positive regulation of insulin secretion [GO:0032024] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; dense core granule [GO:0031045]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133] actin binding [GO:0003779]; myosin binding [GO:0017022]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] DQGQHPR;KFSAVSLCNISTEVLK;LYELAMKMSEK 3 4 0.93327 -0.50889 10.5 0 0 0 0 0 4.66158 9.36431 0 0 0 0 Q8NFX7 STXB6_HUMAN Syntaxin-binding protein 6 (Amisyn) STXBP6 HSPC156 Homo sapiens (Human) negative regulation of exocytosis [GO:0045920]; regulation of SNARE complex assembly [GO:0035542]; SNARE complex assembly [GO:0035493] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; membrane [GO:0016020] cadherin binding involved in cell-cell adhesion [GO:0098641] SQWMLEQLR 1 4.3 0.91014 -0.31648 0 0 0 0 8.65485 0 0 0 0 0 0 0 Q8NFY4 SEM6D_HUMAN Semaphorin-6D SEMA6D KIAA1479 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of smooth muscle cell migration [GO:0014911]; semaphorin-plexin signaling pathway [GO:0071526]; smooth muscle cell migration [GO:0014909]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; ventricular system development [GO:0021591] cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215] EASLYSPPSTLPRNSPTK;EPHFLHAIEYGNYVYFFFR;LNGLFDSPVK;VFKGRFK;VPKPRPGCCAKHGLAEAYK 5 6.8 0.97272 -2.9258 11.7099 11.3066 0 6.91277 7.3587 0 10.1816 0 0 0 0 0 Q8NFY4 SEM6D_HUMAN Semaphorin-6D SEMA6D KIAA1479 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of smooth muscle cell migration [GO:0014911]; semaphorin-plexin signaling pathway [GO:0071526]; smooth muscle cell migration [GO:0014909]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; ventricular system development [GO:0021591] cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215] EPHFLHAIEYGNYVYFFFR;SSLESPTR;VFKGRFK;VPKPRPGCCAKHGLAEAYK 4 8.9 0.91485 -0.39033 0 0 0 7.63815 0 0 0 0 0 0 0 0 Q8NFY9 KBTB8_HUMAN Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) KBTBD8 KIAA1842 TAKRP Homo sapiens (Human) neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; regulation of translation [GO:0006417] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; spindle [GO:0005819] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IYVLQGEFFLFYEPQK;VYEGDGR 2 3.8 0.94166 -0.60379 0 7.14558 0 0 0 10.2976 0 0 0 0 0 10.5762 Q8NFZ0 FBH1_HUMAN F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) FBH1 FBX18 FBXO18 Homo sapiens (Human) DNA catabolic process [GO:0006308]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; response to intra-S DNA damage checkpoint signaling [GO:0072429] chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] EIISDPLFIPWK;GGFIRAK;KRLIMTK;LWDNMRK;MEPLQVVK 5 3.9 0.98095 -1.6241 0 12.4468 0 0 0 0 0 0 0 0 0 10.2419 Q8NFZ3 NLGNY_HUMAN "Neuroligin-4, Y-linked (Neuroligin Y)" NLGN4Y KIAA0951 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625] "asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]" cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023] FTLIDSQAQYPVVNTNYGKIQGLR 1 2.9 0.83537 -0.034544 0 0 0 0 0 0 10.8078 0 0 0 0 0 Q8NFZ4 NLGN2_HUMAN Neuroligin-2 NLGN2 KIAA1366 Homo sapiens (Human) "cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of AMPA receptor activity [GO:2000311]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; synaptic vesicle endocytosis [GO:0048488]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]" "axon [GO:0030424]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dopaminergic synapse [GO:0098691]; excitatory synapse [GO:0060076]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]" cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; signaling receptor activity [GO:0038023] FIHTKPNRFEEVVWSK;FPVVNTAYGRVR 2 3.4 0.96495 -1.1553 9.12707 0 0 0 0 0 0 0 0 9.83583 0 0 Q8NFZ5 TNIP2_HUMAN TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) TNIP2 ABIN2 FLIP1 Homo sapiens (Human) apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162] cytosol [GO:0005829]; nucleoplasm [GO:0005654] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901] EMQQLLSQPQHEREK;HVAECCQ;LTERLEEK;TLTATAHMCQHLAK;WQRYNASRDEYVR 5 13.3 0.97577 -2.3298 0 0 0 4.1692 8.99413 8.09255 12.0009 0 0 0 0 4.79135 Q8NFZ5 TNIP2_HUMAN TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) TNIP2 ABIN2 FLIP1 Homo sapiens (Human) apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162] cytosol [GO:0005829]; nucleoplasm [GO:0005654] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901] HVAECCQ;QQLLSQPQHEREK;TLTATAHMCQHLAK;WQRYNASRDEYVR 4 14.6 0.98185 -1.5887 0 0 0 0 0 0 0 0 0 0 0 11.8989 Q8NFZ6 VN1R2_HUMAN Vomeronasal type-1 receptor 2 (G-protein coupled receptor GPCR25) (hGPCR25) (V1r-like receptor 2) VN1R2 V1RL2 Homo sapiens (Human) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] SRLCSICCRR 1 2.5 0.97777 -1.5156 0 0 0 0 0 7.88081 0 0 0 0 0 0 Q8NFZ8 CADM4_HUMAN Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) CADM4 IGSF4C NECL4 TSLL2 Homo sapiens (Human) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of protein phosphorylation [GO:0001932]; regulation of Rac protein signal transduction [GO:0035020]; regulation of wound healing [GO:0061041]; synaptic membrane adhesion [GO:0099560] cell leading edge [GO:0031252]; cell-cell contact zone [GO:0044291]; synaptic membrane [GO:0097060] protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184] EAFLNGSDGHKR;EGDTLVLTCAVTGNPRPNQIR 2 8.5 0.74556 0.087887 0 0 0 0 0 0 0 0 10.578 0 8.40446 0 Q8NG04 S2610_HUMAN Putative solute carrier family 26 member 10P SLC26A10P SLC26A10 Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; sulfate transmembrane transport [GO:1902358] plasma membrane [GO:0005886] antiporter activity [GO:0015297]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116] GQFRCNLEWHLGLGEGEK 1 3.2 0.94446 -0.63787 0 0 0 0 0 0 0 0 11.1972 0 0 0 Q8NG06 TRI58_HUMAN E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58) TRIM58 Homo sapiens (Human) innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of erythrocyte enucleation [GO:0061931]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of gene expression [GO:0010468]; regulation of nuclear migration along microtubule [GO:1902838]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] dynein heavy chain binding [GO:0045504]; dynein intermediate chain binding [GO:0045505]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] FDTWPCILGLQSFSSGR;KFQVDVK;LQMALELMR;VEMQRQRFR 4 8.6 0.96612 -1.1296 0 0 0 10.1625 8.4219 0 0 0 0 0 0 0 Q8NG08 HELB_HUMAN DNA helicase B (hDHB) (EC 3.6.4.12) HELB Homo sapiens (Human) "DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, synthesis of primer [GO:0006269]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA helicase activity [GO:0017116] HAWARTIHTFQGSEEQTVVYVVGK;ITYREWK;QDCDLINDCCCK;SVLNLLCEHSKLSKLIILGDIR;TLLQENNLQNAK 5 7.1 0.98032 -1.5716 0 0 0 6.28919 5.49099 0 13.503 0 9.52305 0 0 0 Q8NG27 PJA1_HUMAN E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) PJA1 RNF70 Homo sapiens (Human) protein catabolic process [GO:0030163] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] YCDEDSDSDK 1 1.6 0.89754 -0.25306 0 0 0 0 0 0 0 0 0 5.26307 0 0 Q8NG31 KNL1_HUMAN Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) KNL1 CASC5 KIAA1570 Homo sapiens (Human) acrosome assembly [GO:0001675]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; homologous chromosome orientation in meiotic metaphase I [GO:0031619]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of meiosis I spindle assembly checkpoint [GO:1905326]; protein localization to kinetochore [GO:0034501]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940] microtubule binding [GO:0008017] ERIQQSLSNPLSISLTDRK;ILNSEEWFAAACKKELK;LVANDSQLTPLEEWSNNR;NLGVSFPK;NSLTDTWNKDK;VPLENNYLK 6 3.5 0.97182 -1.3527 0 0 0 10.2791 0 9.76893 0 0 10.9105 0 9.42566 0 Q8NG48 LINES_HUMAN Protein Lines homolog 1 (Wnt-signaling molecule Lines homolog 1) LINS1 LINS WINS1 Homo sapiens (Human) cognition [GO:0050890] EIQDAAGTSRDK;LHFTCQR;LTAPHSHRDVCAR;TLSVYEK 4 5.2 0.97816 -2.1424 11.298 12.1021 0 0 9.40799 0 0 0 0 0 10.7237 0 Q8NG50 RDM1_HUMAN RAD52 motif-containing protein 1 (RAD52 homolog B) RDM1 RAD52B Homo sapiens (Human) Cajal body [GO:0015030]; cytosol [GO:0005829]; nucleolus [GO:0005730]; PML body [GO:0016605] DNA binding [GO:0003677]; RNA binding [GO:0003723] FYSARAAHRAQK;VEEESGKIAVEYRPSEDIVGVR 2 14.9 0.98023 -2.005 0 0 0 0 0 0 0 9.57618 0 0 0 0 Q8NG66 NEK11_HUMAN Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) NEK11 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIRNEGSQPAYR;IVEEKYEENSK;MTPRERMR 3 4.8 0.9783 -2.1429 0 0 0 9.29179 0 0 0 0 0 9.60892 0 0 Q8NG68 TTL_HUMAN Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) TTL Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; regulation of axon extension [GO:0030516]; regulation of metaphase plate congression [GO:0090235] spindle microtubule [GO:0005876] ATP binding [GO:0005524]; tubulin-tyrosine ligase activity [GO:0004835] KASLVKLIK 1 2.4 0.83272 -0.029118 0 0 0 0 0 0 0 0 0 0 0 4.84619 Q8NG80 OR2L5_HUMAN Olfactory receptor 2L5 (Olfactory receptor 2L11) (Olfactory receptor OR1-53) OR2L5 OR2L11 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLAVFYTILTPMLNPIIYSLR;YVAICFPLHYPIR 2 10.9 0.91043 -0.29384 0 7.28475 0 0 0 0 0 0 0 0 7.84994 0 Q8NG85 OR2L3_HUMAN Olfactory receptor 2L3 OR2L3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLLAVYHMK 1 2.9 0.908 -0.30284 0 0 0 0 0 0 0 10.6369 0 0 0 0 Q8NG95 OR7G3_HUMAN Olfactory receptor 7G3 (OST085) (Olfactory receptor OR19-9) OR7G3 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPSAGGK 1 2.2 0.6809 0.16457 0 0 0 0 9.76721 0 0 0 0 0 0 0 Q8NGB4 OR4S1_HUMAN Olfactory receptor 4S1 (Olfactory receptor OR11-100) OR4S1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIILFNIVMPPLLNPLIYTLR;SQSSEDRRK;YVAICRPLHYTAIMDCR 3 15.2 0.57997 0.17993 0 0 7.80735 0 0 0 0 0 10.543 6.43232 0 0 Q8NGB8 O4F15_HUMAN Olfactory receptor 4F15 (Olfactory receptor OR15-14) OR4F15 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RLCSRLAHFTK 1 3.5 0.86523 -0.090208 4.75852 0 0 0 0 0 0 0 0 0 0 0 Q8NGC1 O11G2_HUMAN Olfactory receptor 11G2 (Olfactory receptor OR14-34) OR11G2 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IFNSPSNSSTFTGFILLGFPCPR;TVTLFYSVVTPLLNPVIYSLRNK;VPSAAGR 3 15.4 0.84754 -0.061862 11.5869 11.183 0 0 0 0 16.1513 0 0 11.6944 0 0 Q8NGC9 O11H4_HUMAN Olfactory receptor 11H4 (Olfactory receptor OR14-36) OR11H4 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILTLVYSVTTPLFNPLIYTLRNK 1 7.1 0.83432 -0.029624 0 8.6732 0 0 0 0 0 0 0 0 0 0 Q8NGE1 OR6C4_HUMAN Olfactory receptor 6C4 (Olfactory receptor OR12-10) OR6C4 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GIAVLITSVTPLLNPFIYTLR 1 6.8 0.65451 0.16939 7.49873 0 0 0 0 0 0 0 0 0 0 0 Q8NGE2 O2AP1_HUMAN Olfactory receptor 2AP1 (Olfactory receptor OR12-9) OR2AP1 OR2AP1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QPFKDMVKK 1 2.9 0.43298 0.19517 0 0 0 0 0 0 0 0 0 10.4174 0 0 Q8NGF0 O52B6_HUMAN Olfactory receptor 52B6 (Olfactory receptor OR11-47) OR52B6 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MAQVRALHK 1 2.7 0.98099 -1.6069 0 0 0 0 0 0 0 0 0 8.97022 0 0 Q8NGG0 OR8J3_HUMAN Olfactory receptor 8J3 (Olfactory receptor OR11-173) OR8J3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FMENPCYSFK 1 3.2 0.80447 0.01313 0 0 0 0 0 5.85912 0 0 0 0 0 0 Q8NGH5 O56A1_HUMAN Olfactory receptor 56A1 (Olfactory receptor OR11-75) OR56A1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QGIQKLLQRGR 1 3.5 0.77003 0.056362 0 0 0 0 0 0 0 0 0 0 4.81378 0 Q8NGH6 O52L2_HUMAN Putative olfactory receptor 52L2 (Olfactory receptor OR11-74) OR52L2P OR52L2 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GLLLLIPFLILLRK;MNLDSFFSFLLK;NLDSFFSFLLK 3 8.2 0.9174 -0.35754 0 0 0 5.17213 0 0 0 3.07509 11.1115 0 0 0 Q8NGH8 O56A4_HUMAN Olfactory receptor 56A4 (Olfactory receptor OR11-49) OR56A4 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPPDVPILLNILHHLIPPALNPIVYGVRTK;YVAICHPLRYPSIITDQFVAR 2 16.3 0.92913 -0.48429 6.7922 0 0 0 0 0 0 0 0 4.52262 0 0 Q8NGI4 OR4DB_HUMAN Olfactory receptor 4D11 OR4D11 OR4D11P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NQEMKSAMR;SQAGGGR 2 5.1 0.9098 -0.28264 0 0 0 5.87157 10.5248 0 0 0 0 0 0 0 Q8NGJ1 OR4D6_HUMAN Olfactory receptor 4D6 (Olfactory receptor OR11-250) OR4D6 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SHSGEGR 1 2.2 0.82246 -0.017923 0 0 0 0 0 0 0 0 0 0 8.7659 0 Q8NGJ4 O52E2_HUMAN Olfactory receptor 52E2 OR52E2 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALIFVIPSILLILR 1 4.3 0.69325 0.16218 0 0 4.40279 4.0045 0 4.56365 0 5.16084 5.07279 0 0 0 Q8NGJ5 O51L1_HUMAN Olfactory receptor 51L1 (Olfactory receptor OR11-31) OR51L1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IGLACLLR;IGLACLLRSLGVVLPTPLLLR;QIRLGILHKFVLR 3 10.8 0.95239 -0.7563 0 0 0 0 7.42786 5.43853 4.1676 0 0 0 0 0 Q8NGK1 O51G1_HUMAN Olfactory receptor 51G1 (Olfactory receptor 51G3) (Olfactory receptor OR11-29) OR51G1 OR51G3P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SALLILPLPFLLK 1 4 0.70925 0.15822 0 0 0 0 0 0 0 0 0 0 0 6.81031 Q8NGK3 O52K2_HUMAN Olfactory receptor 52K2 (Olfactory receptor OR11-7) OR52K2 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ESILGVFPRK;TKQIRESILGVFPR 2 4.8 0.95535 -0.96844 0 0 0 0 0 0 0 0 0 4.92248 0 0 Q8NGK4 O52K1_HUMAN Olfactory receptor 52K1 (Olfactory receptor OR11-8) OR52K1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VHILLAIFYLLFPPMVNPIIYGVK 1 7.6 0.70879 0.15634 0 0 0 0 0 0 0 0 0 0 0 9.28216 Q8NGK9 OR5DG_HUMAN Olfactory receptor 5D16 (Olfactory receptor OR11-154) OR5D16 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] HRHWYPFNFVIEQ 1 4 0.92236 -0.44703 0 7.75642 0 0 0 0 0 0 0 0 0 0 Q8NGL3 OR5DE_HUMAN Olfactory receptor 5D14 (Olfactory receptor OR11-141) (Olfactory receptor OR11-150) OR5D14 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LLENLVMADK;LQIPLFLVFLLMYVITVVGNLGMIIIIK 2 12.1 0.86676 -0.092582 0 0 0 0 5.26484 0 0 11.9183 10.3976 0 0 0 Q8NGL6 O4A15_HUMAN Olfactory receptor 4A15 (Olfactory receptor OR11-118) OR4A15 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ELLTNNLKFITDPFVCR 1 4.9 0.91827 -0.43557 0 0 0 0 0 0 0 10.3203 0 0 0 0 Q8NGL9 OR4CG_HUMAN Olfactory receptor 4C16 (Olfactory receptor OR11-135) OR4C16 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVFVIFLRLYLGTLLGNLLIIISVK;KIVFVIFLRLYLGTLLGNLLIIISVK 2 8.4 0.72766 0.12583 0 0 3.77273 0 5.42828 0 0 2.75542 0 0 0 0 Q8NGM8 OR6M1_HUMAN Olfactory receptor 6M1 (Olfactory receptor OR11-271) OR6M1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VAAVLITVVTPLLNPFIYSLR 1 6.7 0.65493 0.16939 0 6.09009 3.07324 0 0 7.13504 0 0 0 0 0 0 Q8NGM9 OR8D4_HUMAN Olfactory receptor 8D4 (Olfactory receptor OR11-275) OR8D4 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] YVAICSPLLYR 1 3.5 0.79213 0.016544 0 0 0 0 0 0 0 9.6741 0 0 0 0 Q8NGP0 OR4CD_HUMAN Olfactory receptor 4C13 (Olfactory receptor OR11-260) OR4C13 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LITDSLYENK 1 3.2 0.89746 -0.23547 0 0 0 0 0 0 0 0 0 0 8.91148 0 Q8NGP3 OR5M9_HUMAN Olfactory receptor 5M9 (Olfactory receptor OR11-190) OR5M9 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] DVKEAVNKAITK 1 3.9 0.97828 -1.5033 0 0 0 0 0 0 0 0 0 10.9634 0 0 Q8NGP4 OR5M3_HUMAN Olfactory receptor 5M3 (Olfactory receptor OR11-191) OR5M3 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LNFTDVTEFILLGLTSR 1 5.5 0.6032 0.17819 0 0 0 0 0 0 0 4.62035 0 0 0 9.37221 Q8NGQ1 OR9G4_HUMAN Olfactory receptor 9G4 (Olfactory receptor OR11-216) OR9G4 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLLGVVGFTVLSSILAILISYVNILLAILR 1 9.2 0.71298 0.14555 0 0 0 4.30524 0 0 0 0 0 0 0 0 Q8NGQ2 OR6Q1_HUMAN Olfactory receptor 6Q1 (Olfactory receptor OR11-226) OR6Q1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VTSSINFNK 1 2.8 0.90898 -0.31464 0 0 12.4095 0 0 0 0 0 0 0 8.47642 0 Q8NGQ5 OR9Q1_HUMAN Olfactory receptor 9Q1 OR9Q1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LSLVAGAYVAGLISALVR 1 5.8 0.78659 0.017749 0 0 0 0 0 4.36429 0 0 0 0 0 0 Q8NGQ6 OR9I1_HUMAN Olfactory receptor 9I1 (Olfactory receptor OR11-228) OR9I1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] RLQVSLSM;VTEFILMGFMDHPK 2 7 0.83272 -0.028055 0 6.24192 0 0 0 0 0 0 5.79171 0 0 0 Q8NGR2 OR1L6_HUMAN Olfactory receptor 1L6 (Olfactory receptor 1L7) (Olfactory receptor OR9-30) OR1L6 OR1L7 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSFCASHIIK 1 2.9 0.91727 -0.39875 0 0 0 10.0246 0 0 0 0 0 0 0 0 Q8NGR4 OR5C1_HUMAN Olfactory receptor 5C1 (Olfactory receptor 5C2) (Olfactory receptor 9-F) (OR9-F) OR5C1 OR5C2P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] EALRQTWSR 1 2.8 0.8978 -0.25526 0 0 0 0 0 0 10.3938 0 0 0 0 0 Q8NGS6 O13C3_HUMAN Olfactory receptor 13C3 (Olfactory receptor OR9-8) OR13C3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LQALDKLISLFYGVVTPMLNPILYSLR 1 7.8 0.84087 -0.045996 0 0 7.52505 0 0 0 0 0 0 0 0 0 Q8NGS8 O13C5_HUMAN Olfactory receptor 13C5 (Olfactory receptor OR9-11) OR13C5 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EAVKHLLRR;GLSGHPR;LIFIFYR 3 7.2 0.97668 -2.2086 0 0 0 0 0 0 0 0 8.824 0 0 8.78441 Q8NGT7 O2A12_HUMAN Olfactory receptor 2A12 (Olfactory receptor OR7-10) OR2A12 OR2A12P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLWKQRSM 1 2.6 0.87021 -0.095167 0 0 0 0 0 0 0 0 0 0 8.88813 0 Q8NGU4 OR2I1_HUMAN Putative olfactory receptor 2I1 (Putative olfactory receptor 2I2) (Putative olfactory receptor 2I3) (Putative olfactory receptor 2I4) OR2I1 OR2I1P OR2I2P OR2I3P OR2I4P Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVCCMRFSGGRR 1 3.8 0.86847 -0.093719 0 0 0 0 0 0 0 0 8.43925 0 0 0 Q8NGU9 GP150_HUMAN Probable G-protein coupled receptor 150 GPR150 Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VRLVFLGVILVVAVAGNTTVLCR 1 5.3 0.83497 -0.029624 0 9.64497 0 0 0 0 0 0 0 0 0 0 Q8NGV0 OR2Y1_HUMAN Olfactory receptor 2Y1 (Olfactory receptor OR5-2) OR2Y1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FVALFYTIITPILNPLIYTLRNK;VIVVAVPAALILGSYVHIAHAVLRVK 2 15.8 0.9315 -0.4902 0 0 0 0 0 0 0 0 7.30076 0 4.65272 0 Q8NGV5 O13D1_HUMAN Olfactory receptor 13D1 (Olfactory receptor OR9-15) OR13D1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KVLSRHLHLLK 1 3.2 0.87032 -0.097364 5.08108 0 0 0 0 0 0 0 0 0 0 0 Q8NGW6 OR6K6_HUMAN Olfactory receptor 6K6 (Olfactory receptor OR1-21) OR6K6 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LFHYQKR;MLSCLISEQK 2 5 0.98068 -1.6647 0 0 0 11.2054 9.69493 0 0 0 0 0 0 0 Q8NGX2 O2T35_HUMAN Olfactory receptor 2T35 (Olfactory receptor OR1-66) OR2T35 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MLQDLLSK 1 2.5 0.91403 -0.39033 0 0 0 0 9.81009 0 0 0 0 0 0 0 Q8NGX5 O10K1_HUMAN Olfactory receptor 10K1 (Olfactory receptor OR1-6) OR10K1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] TIGQTFYPLS 1 3.2 0.79609 0.015423 0 0 0 0 0 10.0688 0 0 0 0 0 0 Q8NGY3 OR6K3_HUMAN Olfactory receptor 6K3 (Olfactory receptor OR1-18) OR6K3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] MCWTMPSPFTGSSTR;YQMIMTPR 2 6.9 0.91621 -0.36585 0 0 0 10.0349 0 3.94841 0 0 0 0 0 0 Q8NGY6 OR6N2_HUMAN Olfactory receptor 6N2 (Olfactory receptor OR1-23) OR6N2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] TASGRKK 1 2.2 0.97576 -1.4622 0 0 0 0 0 0 10.1805 0 0 0 0 0 Q8NH09 OR8S1_HUMAN Olfactory receptor 8S1 OR8S1 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAPTALP;NKEVKGER 2 4.2 0.96512 -1.1496 0 0 0 0 0 0 0 0 10.7018 9.20423 0 0 Q8NH21 OR4F5_HUMAN Olfactory receptor 4F5 OR4F5 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QLRKWDAHSSVK;TAIRQLR 2 5.2 0.9168 -0.35051 0 0 0 0 10.8003 8.97688 0 0 0 5.12197 0 0 Q8NH40 OR6S1_HUMAN Olfactory receptor 6S1 (Olfactory receptor OR14-37) OR6S1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LACTNTK;VELFSVFLLVYLLNLTGNVLIVGVVR 2 10 0.88209 -0.16164 0 0 0 0 8.25908 8.27798 0 0 12.134 0 0 0 Q8NH41 OR4KF_HUMAN Olfactory receptor 4K15 (Olfactory receptor OR14-20) OR4K15 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YLKPSQVSVVIRNVLFLETK 1 6.2 0.81769 -0.01737 0 0 0 0 0 0 0 0 0 0 0 7.69683 Q8NH49 OR4X1_HUMAN Olfactory receptor 4X1 (Olfactory receptor OR11-104) OR4X1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YVAICKPLHYMAIMNQRMCGLLVR 1 7.9 0.83551 -0.034544 0 0 0 0 0 9.77218 0 0 0 0 0 0 Q8NH55 O52E5_HUMAN Olfactory receptor 52E5 OR52E5 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIAILGIVIIVR;YIAICNPLRYSMILTNK 2 8.9 0.88763 -0.18468 6.88594 4.95177 0 0 0 7.86109 0 0 9.98057 3.9824 0 0 Q8NH57 O52P1_HUMAN Olfactory receptor 52P1 OR52P1 OR52P1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSSHEARSK 1 2.8 0.97555 -1.4333 0 0 0 0 0 0 0 0 0 12.0764 0 0 Q8NH59 O51Q1_HUMAN Olfactory receptor 51Q1 OR51Q1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SYCLHQDMIR 1 3.2 0.9356 -0.52823 0 9.1732 0 0 0 0 0 0 0 0 0 0 Q8NH60 O52J3_HUMAN Olfactory receptor 52J3 (Olfactory receptor OR11-32) OR52J3 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLYVFTK 1 2.3 0.8823 -0.16563 0 0 0 0 0 8.14944 11.8854 0 0 0 0 0 Q8NH63 O51H1_HUMAN Olfactory receptor 51H1 (Olfactory receptor OR11-25) OR51H1 OR51H1P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVLGIVSRGERLK 1 4.3 0.96122 -1.059 0 0 0 3.05946 0 0 0 0 0 9.40765 9.45024 0 Q8NH64 O51A7_HUMAN Olfactory receptor 51A7 (Olfactory receptor OR11-27) OR51A7 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LKALNTCVSHICAVLTFYVPIITLAAMHHFAKHK 1 10.9 0.4793 0.19049 0 6.53865 0 0 0 0 0 0 0 3.63819 0 0 Q8NH72 OR4C6_HUMAN Olfactory receptor 4C6 (Olfactory receptor OR11-138) OR4C6 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] STTISLK 1 2.3 0.91138 -0.32121 0 0 0 8.24551 0 0 0 0 0 0 0 0 Q8NH92 OR1S1_HUMAN Olfactory receptor 1S1 (Olfactory receptor OR11-232) OR1S1 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VSSTQGK 1 2.2 0.90873 -0.30923 0 0 0 0 0 6.58248 0 0 0 0 0 0 Q8NH93 OR1L3_HUMAN Olfactory receptor 1L3 (Olfactory receptor 9-D) (OR9-D) (Olfactory receptor OR9-28) OR1L3 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TNKICGP 1 2.2 0.98077 -1.5945 9.74665 0 0 0 0 0 0 0 0 0 0 0 Q8NH94 OR1L1_HUMAN Olfactory receptor 1L1 (Olfactory receptor 1L2) (Olfactory receptor 9-C) (OR9-C) (Olfactory receptor OR9-27) OR1L1 OR1L2 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSCSSHFVK 1 2.5 0.93195 -0.49323 0 0 0 0 0 0 0 0 10.1685 0 0 0 Q8NHA4 O2AE1_HUMAN Olfactory receptor 2AE1 (Olfactory receptor 2AE2) OR2AE1 OR2AE2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DVITQCIQR 1 2.8 0.92928 -0.48437 0 0 0 0 0 0 0 0 0 0 0 11.3835 Q8NHB7 OR5K1_HUMAN Olfactory receptor 5K1 (HTPCRX10) (Olfactory receptor OR3-8) OR5K1 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVFCGSNHINHFYCDILPLYR;NREVISVLRK 2 10.1 0.84728 -0.067829 0 0 0 0 0 0 0 0 0 8.44074 0 0 Q8NHH1 TTL11_HUMAN Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11) TTLL11 C9orf20 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; protein modification process [GO:0036211] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" FPGMTEMVR;LSHPRHTLS 2 2.5 0.97136 -1.3485 0 0 0 0 0 0 0 0 0 0 10.7025 12.0229 Q8NHH9 ATLA2_HUMAN Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) ATL2 ARL6IP2 Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] DLVEYFK;GIKFFQR;LSSNNNKK;SFLLDFMLRYMYNK;VFSKLFEVTRR;VTCRDLVEYFK;YMYNKDSQSWIGGNNEPLTGFTWR 7 12.4 0.97486 -3.8458 0 12.1417 0 0 0 0 11.9915 0 0 0 8.5194 10.5053 Q8NHH9 ATLA2_HUMAN Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) ATL2 ARL6IP2 Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] AGLTDQVSHHAR;DLVEYFK;GIKFFQR;SFLLDFMLRYMYNK;VTCRDLVEYFK;YMYNKDSQSWIGGNNEPLTGFTWR 6 11.2 0.93283 -0.50066 0 0 4.2439 9.51863 0 0 0 0 0 0 0 0 Q8NHJ6 LIRB4_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k) LILRB4 ILT3 LIR5 Homo sapiens (Human) "adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of cytotoxic T cell differentiation [GO:0045584]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of IP-10 production [GO:0071659]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of monocyte activation [GO:0150102]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; receptor internalization [GO:0031623]; tolerance induction [GO:0002507]" cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] apolipoprotein binding [GO:0034185]; fibronectin binding [GO:0001968]; inhibitory MHC class I receptor activity [GO:0032396]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]; transmembrane receptor protein tyrosine kinase inhibitor activity [GO:0030293] NTQPEDGVEMDTR 1 2.9 0.8083 0.011202 0 0 0 0 0 7.86034 0 0 0 6.20363 0 0 Q8NHL6 LIRB1_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) LILRB1 ILT2 LIR1 MIR7 Homo sapiens (Human) "adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of endocytosis [GO:0045806]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of osteoclast development [GO:2001205]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transforming growth factor beta production [GO:0071635]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gamma-delta T cell activation involved in immune response [GO:2001193]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; receptor internalization [GO:0031623]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]" cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] HLA-A specific inhibitory MHC class I receptor activity [GO:0030107]; HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; MHC class Ib receptor activity [GO:0032394]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; SH2 domain binding [GO:0042169] HLGVVIGILVAVILLLLLLLLLFLILRHR 1 4.5 0.84236 -0.051328 0 0 0 0 8.22603 0 0 0 0 0 0 0 Q8NHM5 KDM2B_HUMAN Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) KDM2B CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; hindbrain development [GO:0030902]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; rRNA binding [GO:0019843]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] CEACLRTECGECHFCKDMK;EGCEQFIAEMSVSVQFGQVEEK;FGGPGRMK;GKLGPASAVK;LAANRTTAGAR;QLSWLINR;QTEATNAIAEMK;SDDVHLRK;VPLIFREK 9 7.9 0.97856 -6.804 0 0 12.9188 8.22916 0 0 0 9.37812 9.62174 7.70888 9.75238 0 Q8NHP6 MSPD2_HUMAN Motile sperm domain-containing protein 2 MOSPD2 Homo sapiens (Human) chemotaxis [GO:0006935]; lipid droplet formation [GO:0140042]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein homooligomerization [GO:0051260] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] FFAT motif binding [GO:0033149] TLIVLTNVTKNIVAFKVR 1 3.5 0.95742 -1.0289 0 8.30574 0 0 0 0 0 0 0 0 0 0 Q8NHP8 PLBL2_HUMAN Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form] PLBD2 Homo sapiens (Human) phospholipid catabolic process [GO:0009395] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] phospholipase activity [GO:0004620] GLEDSYEGR 1 1.5 0.91004 -0.31633 0 0 0 0 0 0 0 0 0 9.62881 0 0 Q8NHQ1 CEP70_HUMAN Centrosomal protein of 70 kDa (Cep70) (p10-binding protein) CEP70 BITE Homo sapiens (Human) cilium assembly [GO:0060271]; regulation of microtubule cytoskeleton organization [GO:0070507] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802] KIHTQRQYK;NELQLEQSRAANQEQR;QLLCLIDYYESKIR;TLQVKCQHYKK 4 8.4 0.97342 -2.6407 0 0 11.9349 0 8.34194 0 0 0 7.52779 0 6.02086 0 Q8NHQ9 DDX55_HUMAN ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) DDX55 KIAA1595 Homo sapiens (Human) cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FIKNKAWSK;NKIFMEFR;TLAFVIPILEILLR 3 5.2 0.97885 -1.9033 0 0 0 0 0 0 0 0 0 5.82835 0 0 Q8NHS0 DNJB8_HUMAN DnaJ homolog subfamily B member 8 DNAJB8 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of inclusion body assembly [GO:0090084] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] EQLKWMDSK 1 3.9 0.97342 -1.4178 11.7146 0 0 0 0 0 0 0 0 0 0 0 Q8NHS2 AATC2_HUMAN "Putative aspartate aminotransferase, cytoplasmic 2 (EC 2.6.1.1) (Glutamate oxaloacetate transaminase 1-like protein 1) (Transaminase A-like protein 1)" GOT1L1 Homo sapiens (Human) aspartate biosynthetic process [GO:0006532] cytosol [GO:0005829] L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170] LTPSGWAK 1 1.9 0.93034 -0.46937 0 0 0 0 0 0 0 9.49099 0 0 0 0 Q8NHS3 MFSD8_HUMAN Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7) MFSD8 CLN7 Homo sapiens (Human) astrocyte differentiation [GO:0048708]; autophagosome maturation [GO:0097352]; cellular respiration [GO:0045333]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycolipid metabolic process [GO:0006664]; glycolytic process [GO:0006096]; glycoprotein metabolic process [GO:0009100]; inclusion body assembly [GO:0070841]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; maintenance of location [GO:0051235]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; protein stabilization [GO:0050821]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of lysosomal protein catabolic process [GO:1905165]; retina development in camera-type eye [GO:0060041]; TORC1 signaling [GO:0038202] chloride channel complex [GO:0034707]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739] chloride channel activity [GO:0005254]; fluoride channel activity [GO:0062054]; iodide transmembrane transporter activity [GO:0015111] GLLGIGAGNVAVVR;ILGPMFISQVYAHWGPR 2 6 0.94436 -0.63063 0 0 12.2641 0 0 0 0 7.5818 0 8.59451 0 0 Q8NHS4 CLHC1_HUMAN Clathrin heavy chain linker domain-containing protein 1 CLHC1 C2orf63 Homo sapiens (Human) EFLESVQRYIITETER;NIGTMNTFK;VIEHITAYKSILTSIKK 3 7.2 0.95234 -0.75018 0 0 0 0 0 9.48864 0 0 10.5882 0 0 0 Q8NHS9 SPT22_HUMAN Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20) SPATA22 Homo sapiens (Human) fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA repair synthesis [GO:0000711]; regulation of meiotic cell cycle [GO:0051445]; reproductive system development [GO:0061458]; spermatocyte division [GO:0048137] chromosome [GO:0005694] NTLPCVFYEIDR 1 3.3 0.80699 0.012083 0 0 0 0 0 0 0 0 0 0 6.77873 0 Q8NHU2 CFA61_HUMAN Cilia- and flagella-associated protein 61 CFAP61 C20orf26 Homo sapiens (Human) cilium movement [GO:0003341]; cilium organization [GO:0044782]; sperm flagellum assembly [GO:0120316] axoneme [GO:0005930]; motile cilium [GO:0031514] HYTKFFLKEILR;SQDAELRSSSQGSQK;TLVERSTLDYLHYNR 3 3.4 0.95094 -0.69647 0 0 0 0 7.12949 0 8.31188 0 8.31669 0 0 0 Q8NHU3 SMS2_HUMAN Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2) (SMS2) SGMS2 SMS2 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; regulation of bone mineralization [GO:0030500]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188] VQKIGEDNEK 1 2.7 0.98095 -1.5765 0 0 0 0 0 0 0 0 0 0 0 10.4266 Q8NHU6 TDRD7_HUMAN Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) TDRD7 PCTAIRE2BP Homo sapiens (Human) lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; post-transcriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729] FCSLSFQATK;IEDYFHCK;QLGFPTLEAYLR;SLEVHLQVDAMYTNVK;VADLLVK;VTKVDETR 6 5.6 0.97293 -2.5268 0 0 0 7.41185 0 0 0 0 9.48351 0 9.17205 9.53751 Q8NHU6 TDRD7_HUMAN Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) TDRD7 PCTAIRE2BP Homo sapiens (Human) lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; post-transcriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729] IEDYFHCK;KIEDYFHCKITNVHSSR;VTKVDETR 3 6 0.95553 -0.96774 0 8.5572 0 0 0 0 0 0 0 0 0 0 Q8NHV1 GIMA7_HUMAN GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) GTP metabolic process [GO:0046039] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] IAAQAVTK;IWKMLSEIWHR;LLKLKYDEK 3 9.3 0.94594 -0.65531 12.0888 0 10.991 13.2996 0 0 14.5297 9.49919 0 0 0 0 Q8NHV4 NEDD1_HUMAN Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) NEDD1 Homo sapiens (Human) cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278] apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] EENENRDLTAESKK;IYMGKQESK;IYQYDLRMLK 3 5 0.97329 -2.5112 0 7.46263 0 0 0 0 0 9.29285 0 0 0 0 Q8NHV9 RHXF1_HUMAN "Rhox homeobox family member 1 (Ovary-, testis- and epididymis-expressed gene protein) (Paired-like homeobox protein PEPP-1)" RHOXF1 OTEX PEPP1 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" MARSLVHDTVFYCLSVYQVK 1 10.9 0.91805 -0.43484 0 0 0 0 0 0 0 0 0 0 0 9.70094 Q8NHW3 MAFA_HUMAN Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) MAFA Homo sapiens (Human) insulin secretion [GO:0030073]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HILESEKCQLQSQVEQLK 1 5.1 0.82906 -0.023707 0 0 8.19476 0 0 0 7.54805 0 0 0 0 0 Q8NHW4 CC4L_HUMAN C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like) CCL4L1 CCL4L LAG1 SCYA4L1; CCL4L2 CCL4L SCYA4L2 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335] extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] DPIHQSCPTWTMVRQRK 1 25 0.85317 -0.080234 0 0 0 0 0 0 0 0 0 0 0 9.02203 Q8NHX9 TPC2_HUMAN Two pore channel protein 2 (Two pore calcium channel protein 2) TPCN2 TPC2 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; endocytosis involved in viral entry into host cell [GO:0075509]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; intracellular calcium ion homeostasis [GO:0006874]; intracellular pH reduction [GO:0051452]; lysosome organization [GO:0007040]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of developmental pigmentation [GO:0048086]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; release of sequestered calcium ion into cytosol [GO:0051209]; response to vitamin D [GO:0033280]; smooth muscle contraction [GO:0006939]; sodium ion transmembrane transport [GO:0035725] cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; monoatomic ion channel complex [GO:0034702] "calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity [GO:0005245]" LFNELDR;SINHRVDASSMWLYRR;SLQTSLFR;VQLDSSHK;VQLDSSHKQAMMEK 5 6 0.97956 -1.887 0 0 14.9254 0 0 0 8.83678 0 0 11.4738 0 0 Q8NHY2 COP1_HUMAN E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) COP1 RFWD2 RNF200 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ELSVLEEDIK;MEFLKVAR 2 3.6 0.98197 -1.5841 0 0 0 0 0 0 0 0 0 0 0 9.599 Q8NHY2 COP1_HUMAN E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) COP1 RFWD2 RNF200 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] CGHSFCE 1 4.5 0.70997 0.15645 0 0 0 0 0 0 0 0 0 0 0 3.8339 Q8NHY3 GA2L2_HUMAN GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) GAS2L2 GAR17 Homo sapiens (Human) actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; G-protein alpha-subunit binding [GO:0001965]; microtubule binding [GO:0008017] ASLSAKGTHMRK;AVTVDLAGSTHGDCSVEVR;GAFFQFR;SQSPPPPVDWK;VGGGWDTLGHYLDK 5 7.2 0.97301 -2.6601 0 0 0 0 0 9.71848 0 0 0 8.52947 0 0 Q8NHY5 HUS1B_HUMAN Checkpoint protein HUS1B (hHUS1B) HUS1B Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723] checkpoint clamp complex [GO:0030896]; nucleolus [GO:0005730]; site of double-strand break [GO:0035861] DLESMVQVR;DLESMVQVRVDNRK;LQLTHKRRPSLTVAVELVSSLGR;VLPRRVWR 4 16.2 0.9333 -0.51234 0 0 0 0 10.3292 0 0 4.20414 9.61294 8.22077 0 0 Q8NHY6 ZFP28_HUMAN Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6) ZFP28 KIAA1431 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFGDNSSCTQHQR;AHLAQHQKTHTGEKPYECKECGK;KLEAVGTGIEPK;LEAVGTGIEPK 4 5.5 0.93779 -0.57093 0 0 11.2847 0 0 0 0 0 12.6187 8.50748 9.45422 0 Q8NI17 IL31R_HUMAN Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17) IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384 Homo sapiens (Human) acute inflammatory response to antigenic stimulus [GO:0002438]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] ETSYTQYTVKRTYAFGEK;GAPVLEK;KNLTCTWSPGK;NSVTAREFLVSEK;TEPPKIFRVKPVLGIK 5 8.9 0.97973 -2.0006 0 14.7979 0 7.36063 0 0 7.84436 11.1981 0 0 0 8.5562 Q8NI17 IL31R_HUMAN Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17) IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384 Homo sapiens (Human) acute inflammatory response to antigenic stimulus [GO:0002438]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] ETSYTQYTVKRTYAFGEK;GAPVLEK;KNLTCTWSPGK;LNLKESDDSVNTEDRIR;TEPPKIFRVKPVLGIK 5 11.3 0.97638 -1.4796 0 0 0 0 0 0 0 0 0 8.45644 0 0 Q8NI17 IL31R_HUMAN Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17) IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384 Homo sapiens (Human) acute inflammatory response to antigenic stimulus [GO:0002438]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] GAPVLEK;MTYWRLENIAKTEPPK;NSVTAREFLVSEK;TEPPKIFRVKPVLGIK 4 7.6 0.4372 0.1947 0 0 8.83042 0 0 0 0 0 0 0 0 0 Q8NI27 THOC2_HUMAN THO complex subunit 2 (Tho2) (hTREX120) THOC2 CXorf3 Homo sapiens (Human) generation of neurons [GO:0048699]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; neuron development [GO:0048666]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] mRNA binding [GO:0003729] EVPPDLTKRR;ISSGGKKESR;LEKDNWLLAKSTK;LIALAICKLIHITIEPLYR;QMEHVQR;SFMKEFQSDGSKQEDK;TPATTPEAR 7 5.3 0.97322 -2.8851 0 8.38866 9.59115 7.11884 0 4.29418 0 8.73829 0 8.59653 0 0 Q8NI29 FBX27_HUMAN F-box only protein 27 (F-box/G-domain protein 5) FBXO27 FBG5 FBX27 Homo sapiens (Human) ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] IEICVSDWWGAR 1 4.2 0.80369 0.01341 0 0 0 0 0 0 0 0 0 0 10.1762 0 Q8NI32 LPD6B_HUMAN Ly6/PLAUR domain-containing protein 6B LYPD6B Homo sapiens (Human) extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] acetylcholine receptor regulator activity [GO:0030548] DSEHTECR;NINFYNVRPPLDPTPFPNSFK;WCPQNTQYCLTVHHFTSHGR 3 26.8 0.95208 -0.72071 0 0 0 13.7501 0 0 0 0 0 7.97114 5.16627 0 Q8NI35 INADL_HUMAN InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) PATJ CIPP INADL Homo sapiens (Human) establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; tight junction assembly [GO:0120192] apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LAVSQMK;LSMFYETLK;SLVADGVAER;VISKASAYTGMLSSR 4 2.3 0.98156 -1.7652 0 12.3049 0 0 0 0 9.92979 0 12.1089 0 0 0 Q8NI35 INADL_HUMAN InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) PATJ CIPP INADL Homo sapiens (Human) establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; tight junction assembly [GO:0120192] apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LAVSQMK;SFPEKFRHR;SLVADGVAER;VISKASAYTGMLSSR 4 3.6 0.56241 0.18254 0 0 0 0 0 0 0 0 10.7183 0 0 0 Q8NI36 WDR36_HUMAN WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) WDR36 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; visual perception [GO:0007601] nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] EIVHTFK;FAAEEAR;FWNFKNK;GLGTCFPSGPELR;ISAILHPSTYLNK 5 4.9 0.97431 -3.5122 0 10.6695 0 0 0 0 12.6824 0 0 0 0 0 Q8NI38 IKBD_HUMAN NF-kappa-B inhibitor delta (NFKB inhibitor delta) (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS) (T-cell activation NFKB-like protein) (TA-NFKBH) NFKBID IKBNS Homo sapiens (Human) inflammatory response [GO:0006954]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852] nucleus [GO:0005634] VAPPGLSS;VLSTQARDR 2 5.4 0.96739 -1.3139 0 0 0 0 0 6.96394 0 12.0751 6.28533 0 7.57607 0 Q8NI51 CTCFL_HUMAN Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T) CTCFL BORIS Homo sapiens (Human) establishment of protein localization to chromatin [GO:0071169]; genomic imprinting [GO:0071514]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" ELELMPEK;ELELMPEKGLK;GEQFPGEMFPVACRETTARVK 3 4.8 0.95381 -0.91695 0 0 0 0 0 0 0 0 0 9.982 13.2354 0 Q8NI77 KI18A_HUMAN Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) KIF18A OK/SW-cl.108 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; male meiotic nuclear division [GO:0007140]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; seminiferous tubule development [GO:0072520] caveola [GO:0005901]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; microtubule cytoskeleton [GO:0015630]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; ruffle [GO:0001726] actin binding [GO:0003779]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; plus-end-directed microtubule motor activity [GO:0008574]; tubulin-dependent ATPase activity [GO:0070463] NICKINPSMVR;RSYLEKR;VVHVVDK 3 2.8 0.97296 -2.9205 6.21224 0 0 0 0 0 12.187 12.5947 0 7.61449 0 0 Q8TA86 RP9_HUMAN Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) RP9 Homo sapiens (Human) cognition [GO:0050890]; RNA splicing [GO:0008380] nucleus [GO:0005634]; signal recognition particle receptor complex [GO:0005785] metal ion binding [GO:0046872]; RNA binding [GO:0003723] EPPEQELQR;EPPEQELQRRR 2 5 0.91745 -0.41205 0 0 0 0 0 0 0 0 0 0 0 7.9151 Q8TA94 ZN563_HUMAN Zinc finger protein 563 ZNF563 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ALSHSSSFR;GRPHTGK;HMIMHTGGGPHK;QCGKTLSHSSSFRR;RHTGDRPHKCK;TFHHLGSFQIHMKR;THTGEKPYTCKQCGK 7 17 0.97501 -4.1133 12.5856 10.2404 0 0 0 11.0647 0 0 10.9302 0 0 0 Q8TAA1 RNS11_HUMAN Probable ribonuclease 11 (RNase 11) (EC 3.1.27.-) RNASE11 C14orf6 UNQ5832/PRO19669 Homo sapiens (Human) defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576] endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676] EEFTDEEMQYDMAK 1 7 0.8019 0.014442 0 0 0 0 0 0 0 0 0 0 5.48861 0 Q8TAA3 PSMA8_HUMAN Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) PSMA8 PSMA7L Homo sapiens (Human) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of meiosis I [GO:0060631]; spermatogenesis [GO:0007283] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]; spermatoproteasome complex [GO:1990111]" ALLEVVQSGGK;ANAIGRSAK;LAIKALLEVVQSGGK 3 9.4 0.9801 -1.5615 0 0 0 0 0 0 0 0 0 0 8.65921 0 Q8TAA5 GRPE2_HUMAN "GrpE protein homolog 2, mitochondrial (Mt-GrpE#2)" GRPEL2 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]" adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] QDGYKLHGR;VFRGLLLLEAKLK 2 9.8 0.96731 -1.3146 0 0 0 0 0 10.7525 0 0 0 0 9.49368 0 Q8TAA5 GRPE2_HUMAN "GrpE protein homolog 2, mitochondrial (Mt-GrpE#2)" GRPEL2 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]" adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] EVQDLTESR;LEKEVQDLTESRVSVR;TKSSLWRR 3 19.7 0.96757 -1.3211 0 0 0 0 0 0 0 7.59529 0 0 0 3.03598 Q8TAB3 PCD19_HUMAN Protocadherin-19 PCDH19 KIAA1313 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DNKEIRTYNCR;SLDRETQSHYSFR 2 2.2 0.97835 -1.5308 0 0 8.24978 0 0 0 11.0823 0 0 0 0 0 Q8TAB5 CA216_HUMAN UPF0500 protein C1orf216 C1orf216 Homo sapiens (Human) EQEKEKHHVHLVMYR;LQESFDTILDNR 2 11.8 0.2734 0.25642 0 0 0 0 0 0 0 0 0 10.9058 8.24835 0 Q8TAC1 RFESD_HUMAN Rieske domain-containing protein RFESD Homo sapiens (Human) "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" SERMTAVVHDR 1 7 0.98041 -1.5967 0 0 0 0 0 0 0 0 0 0 0 9.77032 Q8TAC2 JOS2_HUMAN Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2) JOSD2 SBBI54 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829] cysteine-type deubiquitinase activity [GO:0004843] RRPLSQLALPQVLGLILNLPSPVSLGLLSLPLRR 1 18.1 0.48112 0.19045 0 0 0 0 0 0 0 0 0 5.39352 0 0 Q8TAC9 SCAM5_HUMAN Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5) SCAMP5 Homo sapiens (Human) exocytosis [GO:0006887]; negative regulation of endocytosis [GO:0045806]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of cytokine production [GO:0001819]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976] Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] protein-containing complex binding [GO:0044877] GSGGSFSK 1 3.4 0.91565 -0.39033 0 0 0 0 0 0 0 0 0 0 6.56389 0 Q8TAD4 ZNT5_HUMAN Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5) (ZnT-like transporter 1) (hZTL1) SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879 Homo sapiens (Human) cobalt ion transport [GO:0006824]; GPI anchor biosynthetic process [GO:0006506]; insulin processing [GO:0030070]; intracellular zinc ion homeostasis [GO:0006882]; response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588] antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] AVHIVQFIFILK 1 1.6 0.71074 0.15593 0 0 0 0 0 5.42328 0 0 0 0 0 0 Q8TAD7 OCC1_HUMAN Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) OCC1 C12orf75 Homo sapiens (Human) DVTEESVTEDDKR 1 20.6 0.87661 -0.13064 0 0 0 0 0 0 9.30234 0 0 0 0 0 Q8TAD8 SNIP1_HUMAN Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) SNIP1 Homo sapiens (Human) "miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; U2-type prespliceosome assembly [GO:1903241]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416] DDEDEEEEEEVSDS;EFYNARR;GVSRSPPK;SGHRGNR 4 9.1 0.97332 -2.9121 0 0 0 0 0 0 0 7.45376 0 0 0 0 Q8TAE8 G45IP_HUMAN "Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)" GADD45GIP1 MRPL59 PLINP1 PRG6 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] MAASVRQAR;QLAEEQK;SLLGVAATLAPGSRGYR 3 14.9 0.97878 -1.9656 0 0 7.88307 0 0 0 0 0 0 0 0 0 Q8TAF5 LQK1_HUMAN Putative uncharacterized protein LQK1 (FLVCR1 antisense RNA 1) (FLVCR1 divergent transcript) FLVCR1-DT FLVCR1-AS1 LQK1 Homo sapiens (Human) VGGRRPR;VLGSTSGKNWR 2 20.5 0.98089 -1.7998 0 5.59069 0 0 0 0 10.9878 0 0 0 6.95641 0 Q8TAG5 VTM2A_HUMAN V-set and transmembrane domain-containing protein 2A VSTM2A VSTM2 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of white fat cell proliferation [GO:0070352] extracellular region [GO:0005576]; membrane [GO:0016020] identical protein binding [GO:0042802] GPEDLDPGAEGAGAQVELLPDRDPDSDGTK 1 12.7 0.84206 -0.045328 0 0 0 0 0 0 0 0 0 0 8.50871 0 Q8TAG6 VEXIN_HUMAN Vexin VXN C8orf46 Homo sapiens (Human) neurogenesis [GO:0022008]; neuron differentiation [GO:0030182] nucleus [GO:0005634]; plasma membrane [GO:0005886] EGSCSDER 1 6 0.91455 -0.39033 0 0 0 0 0 0 0 0 0 0 0 5.98286 Q8TAG9 EXOC6_HUMAN Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) EXOC6 SEC15A SEC15L SEC15L1 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] DFLESIRK;IQQRNITTVVEKLQLCLPVLEMYSK;LFDLLFEIR;SLVNGMSQHM;SSTEIDDMLR 5 7.7 0.95393 -0.91879 0 0 0 9.10724 0 11.0081 11.0802 10.8946 10.9212 15.2988 0 0 Q8TAI1 TYMOS_HUMAN TYMS opposite strand protein TYMSOS C18orf56 Homo sapiens (Human) HLSGCSAPACR;RTMRPLPR 2 15.4 0.95203 -0.71252 6.20965 0 9.35021 0 0 0 0 0 0 0 0 0 Q8TAK6 OLIG1_HUMAN Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21) OLIG1 BHLHB6 BHLHE21 Homo sapiens (Human) axon development [GO:0061564]; neuron fate commitment [GO:0048663]; oligodendrocyte development [GO:0014003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" RMQDLNLAMDALR 1 4.8 0.41393 0.20217 0 0 0 0 0 0 0 0 9.10748 0 0 0 Q8TAL5 CI043_HUMAN Uncharacterized protein C9orf43 C9orf43 Homo sapiens (Human) FYSKFHGRPPK;KAKSDPGIQSTSHK 2 5.4 0.98007 -1.6007 0 0 0 0 0 0 12.7603 0 0 0 0 0 Q8TAM1 BBS10_HUMAN BBSome complex assembly protein BBS10 (Bardet-Biedl syndrome 10 protein) BBS10 C12orf58 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; cone retinal bipolar cell differentiation [GO:1904390]; negative regulation of neuron apoptotic process [GO:0043524]; neuronal action potential [GO:0019228]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; protein localization [GO:0008104]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; response to light stimulus [GO:0009416]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; visual perception [GO:0007601] cilium [GO:0005929] ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] DPLMCENIQTHGRHWK;LLISSVK;RHPQKVHNQDSEDEL 3 5.3 0.96733 -1.3094 0 0 0 0 0 0 0 0 0 0 10.3235 0 Q8TAM2 TTC8_HUMAN Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) TTC8 BBS8 Homo sapiens (Human) axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] IYEEMNNMSSAAEYYK;SPYDQEPDPELPVHQAAWILK;TAYTARPITSSSGR 3 9.4 0.10121 0.36794 0 0 0 0 0 0 10.9824 0 0 0 7.48712 6.90965 Q8TAM6 ERMIN_HUMAN Ermin (Juxtanodin) (JN) ERMN KIAA1189 Homo sapiens (Human) actin filament organization [GO:0007015]; morphogenesis of a branching structure [GO:0001763]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glial cell projection [GO:0097386]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270] actin filament binding [GO:0051015] MLKENPEEK 1 3.2 0.91908 -0.43802 0 10.1049 0 0 0 0 0 0 0 0 0 0 Q8TAP4 LMO3_HUMAN LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3) LMO3 RBTN3 RBTNL2 RHOM3 Homo sapiens (Human) negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucocorticoid receptor signaling pathway [GO:2000324]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] IKDRYLLK;LIPAFEMVMR;YWHEDCLKCACCDCR 3 22.8 0.91739 -0.42806 0 0 0 0 0 11.5702 0 0 0 9.76326 8.12386 5.03879 Q8TAP6 CEP76_HUMAN Centrosomal protein of 76 kDa (Cep76) CEP76 C18orf9 Homo sapiens (Human) regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] APVIGGGGK;MADSTTMLSISDPIHMVLIK;QEQWCTLLAFLCR;SLPPEKASELK 4 8 0.97841 -1.9371 0 0 14.6321 0 0 0 4.14233 9.50563 8.75472 0 9.88679 0 Q8TAP8 PPR35_HUMAN Protein phosphatase 1 regulatory subunit 35 PPP1R35 C7orf47 Homo sapiens (Human) notochord morphogenesis [GO:0048570]; positive regulation of centriole elongation [GO:1903724]; positive regulation of cilium assembly [GO:0045724] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864] LQLRPRPSEDTFLMHRTLR 1 7.5 0.88854 -0.20109 0 0 0 10.8874 0 0 0 0 0 0 0 0 Q8TAP9 MPLKI_HUMAN M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) MPLKIP C7orf11 TTDN1 Homo sapiens (Human) cell division [GO:0051301] centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] TSTPFGSGR 1 5 0.90994 -0.31546 0 0 8.42668 0 0 0 0 0 0 0 0 0 Q8TAQ2 SMRC2_HUMAN SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) SMARCC2 BAF170 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] histone binding [GO:0042393]; transcription coactivator activity [GO:0003713] EGGGAIEEEAKEK;EPREGGGAIEEEAKEK;TSEAPKK;VASAAAK 4 2.5 0.97568 -3.3199 0 0 0 0 0 10.5138 12.1352 0 0 0 0 0 Q8TAQ5 ZN420_HUMAN Zinc finger protein 420 ZNF420 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECGKMFSHGSQLTQHQRIHTGEKPYQCK 1 4.1 0.70758 0.15938 0 0 0 0 0 0 0 0 9.36006 0 0 0 Q8TAS1 UHMK1_HUMAN Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) UHMK1 KIS KIST Homo sapiens (Human) neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of translational initiation [GO:0045948]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of protein export from nucleus [GO:0046825] axon [GO:0030424]; dendrite cytoplasm [GO:0032839]; intracellular membrane-bounded organelle [GO:0043231]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribonucleoprotein complex binding [GO:0043021]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; transferase activity [GO:0016740] FVVATFYPLSAYKR;LGSGSSASVYR;YIQTDGYR 3 7.9 0.97625 -1.4667 0 0 0 0 0 0 0 11.0323 11.9246 0 0 0 Q8TAT2 FGFP3_HUMAN Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3) FGFBP3 C10orf13 PSEC0101 Homo sapiens (Human) cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201] CAAYAARRAHFWK;QVLGGLR 2 7.8 0.84668 -0.064953 0 0 0 0 0 0 8.45841 0 0 12.3992 0 0 Q8TAT5 NEIL3_HUMAN Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) NEIL3 Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depurination [GO:0045007]; interstrand cross-link repair [GO:0036297]; single strand break repair [GO:0000012]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bubble DNA binding [GO:0000405]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; MCM complex binding [GO:1904931]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] ELDVCSPEFSFLR;IHFGMKGFIMINPLEYK;VEGPGCTLNGEKIR;VYKRPNCGQCHCRITVCR 4 10.2 0.95486 -0.9487 0 0 0 0 8.79961 0 9.57446 0 0 0 6.86369 0 Q8TAT6 NPL4_HUMAN Nuclear protein localization protein 4 homolog (Protein NPL4) NPLOC4 KIAA1499 NPL4 Homo sapiens (Human) "ERAD pathway [GO:0036503]; Golgi organization [GO:0007030]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] KLTGGADK 1 1.3 0.83997 -0.043952 0 0 0 0 10.477 0 0 0 0 0 0 0 Q8TAU0 NKX23_HUMAN Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog C) NKX2-3 NKX23 NKX2C Homo sapiens (Human) "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; gland morphogenesis [GO:0022612]; leukocyte homeostasis [GO:0001776]; leukocyte migration [GO:0050900]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; odontogenesis of dentin-containing tooth [GO:0042475]; Peyer's patch development [GO:0048541]; plasma cell differentiation [GO:0002317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic digestive tract morphogenesis [GO:0048621]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; saliva secretion [GO:0046541]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]; triglyceride metabolic process [GO:0006641]" chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KSLETAGDCK 1 2.7 0.73607 0.11152 0 0 0 0 0 0 8.5727 0 0 0 0 0 Q8TAU3 ZN417_HUMAN Zinc finger protein 417 ZNF417 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DGCYVCSDCGK;ECGKLFNR;VHTGERPYECREYGK 3 5.9 0.89688 -0.2361 0 0 9.4793 0 0 0 0 0 0 0 0 0 Q8TAV0 FA76A_HUMAN Protein FAM76A FAM76A Homo sapiens (Human) nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] EVTEQLQAKNR;ITELKADFQYQESQMR;SGAITSP 3 11.1 0.90832 -0.30245 10.1855 0 0 8.63052 0 9.68159 9.86989 0 2.25223 0 0 11.1981 Q8TAV4 STML3_HUMAN Stomatin-like protein 3 (SLP-3) STOML3 Homo sapiens (Human) signal transduction [GO:0007165] cilium [GO:0005929]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] TVTCNIPPQEILTR;VEIKDVRIPVQLQR 2 9.6 0.40886 0.20546 0 0 0 0 0 0 0 0 10.9771 8.93958 0 0 Q8TAW3 ZN671_HUMAN Zinc finger protein 671 ZNF671 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AFSCISKLIQHQK;AHGPMAELTDSAR;IHSSDYECSR;LIQHQKVHSGEKPYECSKCGK;LVSGFLMGQRYHR;SRAVMKLER 6 13.7 0.98082 -1.7586 0 0 8.76002 0 0 7.36667 4.15478 3.88382 0 8.24303 8.37086 0 Q8TAX9 GSDMB_HUMAN "Gasdermin-B (Gasdermin-like protein) [Cleaved into: Gasdermin-B, N-terminal (GSDMB-NT) (p30); Gasdermin-B, C-terminal (GSDMB-CT) (p16)]" GSDMB GSDML PP4052 PRO2521 Homo sapiens (Human) cytotoxic T cell pyroptotic cell death [GO:1902483]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; programmed cell death [GO:0012501]; pyroptotic inflammatory response [GO:0070269] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] "cardiolipin binding [GO:1901612]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; wide pore channel activity [GO:0022829]" AEFQILDNVDSTGELIVRLPK;DVLNSLAKCLGK;EDIRQDLEQR;EITISGSFQGFHHQKIK;ISENRISQQYLATLENR 5 18.5 0.97278 -2.925 0 12.5358 0 10.5874 0 10.1037 11.4418 0 0 0 0 0 Q8TAY7 F110D_HUMAN Protein FAM110D FAM110D GRRP1 Homo sapiens (Human) TPRPVRR 1 2.6 0.78457 0.029797 0 0 0 0 0 6.80129 0 0 0 0 0 0 Q8TB03 CX038_HUMAN Uncharacterized protein CXorf38 CXorf38 Homo sapiens (Human) mitochondrion [GO:0005739] LDSQEPGR;NGLTEDMQKLDSLCLHQK 2 8.2 0.96491 -1.2354 0 0 0 0 0 0 10.9836 0 0 0 0 0 Q8TB22 SPT20_HUMAN Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411) SPATA20 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; mitochondrion [GO:0005739] PAGGKGSHPSSTPQR 1 2 0.88217 -0.16609 0 0 0 0 0 0 9.97499 0 0 0 0 0 Q8TB24 RIN3_HUMAN Ras and Rab interactor 3 (Ras interaction/interference protein 3) RIN3 Homo sapiens (Human) endocytosis [GO:0006897]; negative regulation of mast cell chemotaxis [GO:0060755]; negative regulation of receptor internalization [GO:0002091]; regulation of vesicle size [GO:0097494]; signal transduction [GO:0007165] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; vesicle [GO:0031982] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] GEEEEEEDGMR;GISILEK;LCLPANPK 3 2.6 0.96438 -1.1973 0 4.36001 0 0 0 0 10.2613 0 10.5106 0 0 0 Q8TB36 GDAP1_HUMAN Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Homo sapiens (Human) cellular response to vitamin D [GO:0071305]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778] ESMYYPRVQHYR;RPNLETYYERVLKR 2 7.3 0.93705 -0.53836 0 0 0 0 0 7.71425 0 0 0 6.75596 8.27006 0 Q8TB40 ABHD4_HUMAN (Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4) ABHD4 Homo sapiens (Human) lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739] hydrolase activity [GO:0016787]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipase activity [GO:0004622] ILQCLQNK 1 2.3 0.92982 -0.48656 0 0 0 0 0 0 0 10.6315 0 0 0 0 Q8TB45 DPTOR_HUMAN DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) DEPTOR DEPDC6 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TORC2 signaling [GO:1903940]; positive regulation of autophagy [GO:0010508]; regulation of extrinsic apoptotic signaling pathway [GO:2001236] lysosomal membrane [GO:0005765] phosphatidic acid binding [GO:0070300]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291] LHEEKVIK;RRLMELLNEK;TIVMEVMEELEC 3 7.3 0.89698 -0.23471 11.7775 0 0 9.59016 0 0 0 0 10.6601 0 0 11.0775 Q8TB69 ZN519_HUMAN Zinc finger protein 519 ZNF519 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HLTVKGDKEYR;LIFPENIHIQK;YGSCGLENICLWK 3 6.5 0.38589 0.2154 0 5.71636 0 5.30239 0 8.82871 10.5954 0 0 0 0 0 Q8TB72 PUM2_HUMAN Pumilio homolog 2 (Pumilio-2) PUM2 KIAA0235 PUMH2 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; adipose tissue development [GO:0060612]; chromosome organization [GO:0051276]; hair follicle development [GO:0001942]; miRNA processing [GO:0035196]; mitochondrion organization [GO:0007005]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of sprouting of injured axon [GO:0048687]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of chromosome segregation [GO:0051983]; regulation of intracellular mRNA localization [GO:1904580]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of postsynapse assembly [GO:0150052]; regulation of translation [GO:0006417]; respiratory electron transport chain [GO:0022904]; skeletal system development [GO:0001501]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pumilio-response element binding [GO:0062104]; RNA binding [GO:0003723] DQYANYVVQK;GLPNGMDADCK;LDSRFRK;SDIMPSGRSR;YISAAPGAEAKYR 5 4.8 0.97687 -4.8708 0 0 0 0 0 11.4594 0 0 0 0 0 0 Q8TB73 NDNF_HUMAN Protein NDNF (Neuron-derived neurotrophic factor) NDNF C4orf31 UNQ2748/PRO6487 Homo sapiens (Human) angiogenesis [GO:0001525]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]; response to ischemia [GO:0002931]; vascular wound healing [GO:0061042] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201] FLRFAPVSSHQKVTFFIHSCLDAVQIQVR;KGASMLK 2 6.3 0.9668 -1.3005 0 0 0 10.5139 0 11.3274 11.5324 7.49602 0 0 0 0 Q8TB96 TIP_HUMAN T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin) ITFG1 LNKN-1 TIP CDA08 Homo sapiens (Human) extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] VIVLSGLCSNDCPR 1 2.3 0.78452 0.023794 0 0 0 5.72345 0 0 8.40408 0 0 0 0 0 Q8TBA6 GOGA5_HUMAN Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) GOLGA5 RETII RFG5 PIG31 Homo sapiens (Human) "Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" cis-Golgi network [GO:0005801]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] DRDEEIQK;NSLVFQLER 2 2.3 0.95733 -0.84772 0 0 8.10003 0 0 10.4611 0 0 0 0 6.49677 0 Q8TBB0 THAP6_HUMAN THAP domain-containing protein 6 THAP6 Homo sapiens (Human) microtubule cytoskeleton [GO:0015630] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ELKDECLISQETANR;GLTFHVFPTDENIK;HKLDHVIGELEDTK 3 19.4 0.95519 -0.79243 0 12.9425 0 0 0 10.8447 10.4683 0 0 0 0 0 Q8TBB1 LNX1_HUMAN E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX) LNX1 LNX PDZRN2 UNQ574/PRO1136 Homo sapiens (Human) protein ubiquitination [GO:0016567]; synapse maturation [GO:0060074]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; postsynapse [GO:0098794] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842] EWDLPIYVISVEPGGVISR 1 2.6 0.90814 -0.27659 0 0 0 0 0 9.60053 0 0 0 0 0 0 Q8TBB6 S7A14_HUMAN Solute carrier family 7 member 14 (Gamma-aminobutyric acid transporter SLC7A14) SLC7A14 KIAA1613 Homo sapiens (Human) amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185] VQWGAAWYAMHSRILR 1 2.1 0.91628 -0.43068 0 0 0 0 0 9.38299 0 0 0 0 0 0 Q8TBC3 SHKB1_HUMAN SH3KBP1-binding protein 1 (SETA-binding protein 1) SHKBP1 SB1 PP203 Homo sapiens (Human) positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein homooligomerization [GO:0051260] lysosome [GO:0005764] identical protein binding [GO:0042802] RLGSRPR;VIVQHPETVGSGPQLFQTFTVHR 2 4.2 0.93337 -0.50842 0 0 0 0 0 0 0 0 0 0 9.13661 0 Q8TBC4 UBA3_HUMAN NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) UBA3 UBE1C Homo sapiens (Human) endomitotic cell cycle [GO:0007113]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NEDD8 activating enzyme activity [GO:0019781]; NEDD8 transferase activity [GO:0019788]; protein heterodimerization activity [GO:0046982] AEVAAEFLNDR;MADGEEPMAVDGGCGDTGDWEGR;SPAITATLEGK 3 10 0.98042 -1.5536 0 0 11.079 0 0 0 0 0 0 0 0 0 Q8TBC5 ZSC18_HUMAN Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) ZSCAN18 ZNF447 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDTEELR;LVERDPQGSSLPGGR;TFHFSLALAEHQKTHEKEK 3 11 0.96463 -1.2334 0 0 0 0 0 0 0 8.77939 8.27612 0 10.1542 0 Q8TBE0 BAHD1_HUMAN Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) BAHD1 KIAA0945 Homo sapiens (Human) heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892] chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; transcription cis-regulatory region binding [GO:0000976] AGDPHRSRDR;LSQERELPLR;NYPLRKRPLVPEKPK 3 4.5 0.88685 -0.19333 0 8.86996 0 8.09075 0 0 0 0 0 5.09216 0 0 Q8TBE7 S35G2_HUMAN Solute carrier family 35 member G2 (Transmembrane protein 22) SLC35G2 TMEM22 Homo sapiens (Human) Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] GLLSEMKKK;KMWIVLFGSALAHGCVALITRLVSDR 2 8.5 0.97573 -2.3122 0 0 0 0 0 0 0 0 8.97711 0 0 0 Q8TBF2 PXL2B_HUMAN Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B) PRXL2B C1orf93 FAM213B Homo sapiens (Human) prostaglandin biosynthetic process [GO:0001516] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin F synthase activity [GO:0047017]" SLWREHACVVAGLR 1 7.1 0.82872 -0.023246 0 0 0 0 0 8.91606 0 0 0 0 0 0 Q8TBF4 ZCRB1_HUMAN Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K) ZCRB1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] STYFSDEEELSD 1 5.5 0.8081 0.0088527 0 4.17329 0 0 0 0 0 0 0 0 0 0 Q8TBF8 FA81A_HUMAN Protein FAM81A FAM81A Homo sapiens (Human) "glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]" molecular condensate scaffold activity [GO:0140693] LDRDQLQK 1 2.2 0.97525 -1.458 0 0 0 0 0 0 11.4036 0 0 0 0 0 Q8TBG4 AT2L1_HUMAN Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) ETNPPL AGXT2L1 Homo sapiens (Human) mitochondrial matrix [GO:0005759] ethanolamine-phosphate phospho-lyase activity [GO:0050459]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GIGLFIGIDLVKDHLK;VFFASDPIK;VGNYLTELLK 3 7 0.97097 -1.3399 0 0 0 0 0 8.95765 0 0 0 0 0 0 Q8TBH0 ARRD2_HUMAN Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] VLLELSSAARVGALRLR 1 4.2 0.54899 0.18385 4.08916 0 0 0 0 0 0 0 0 0 0 0 Q8TBJ5 FEZF2_HUMAN Fez family zinc finger protein 2 (Forebrain embryonic zinc finger-like protein 2) (Zinc finger protein 312) (Zinc finger protein Fez-like) FEZF2 FEZL ZNF312 FKSG36 Homo sapiens (Human) axonal fasciculation [GO:0007413]; cell dedifferentiation [GO:0043697]; cerebral cortex GABAergic interneuron migration [GO:0021853]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; dendrite development [GO:0016358]; dentate gyrus development [GO:0021542]; forebrain anterior/posterior pattern specification [GO:0021797]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; neuron fate determination [GO:0048664]; positive regulation of neuron differentiation [GO:0045666]; regulation of axon guidance [GO:1902667]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KPFTCATCGKGFCR;LAGLAADK;LAGLAADKFPHPAPYPHKER 3 7.4 0.97381 -1.3992 0 0 0 0 8.77673 0 0 0 0 0 0 0 Q8TBK2 SETD6_HUMAN N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6) SETD6 Homo sapiens (Human) negative regulation of NF-kappaB transcription factor activity [GO:0032088]; peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NF-kappaB binding [GO:0051059]; protein-lysine N-methyltransferase activity [GO:0016279]; S-adenosyl-L-methionine binding [GO:1904047] VSERAGGR 1 1.7 0.9128 -0.33804 7.71966 0 0 0 0 8.45446 0 0 0 0 0 0 Q8TBM8 DJB14_HUMAN DnaJ homolog subfamily B member 14 DNAJB14 UNQ9427/PRO34683 Homo sapiens (Human) cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein-containing complex assembly [GO:0065003] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] Hsp70 protein binding [GO:0030544] FLQKAEK 1 1.8 0.96638 -1.277 0 0 0 0 0 0 0 11.9624 0 0 0 0 Q8TBN0 R3GEF_HUMAN Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) RAB3IL1 Homo sapiens (Human) exocytosis [GO:0006887]; protein transport [GO:0015031] cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802] ELHPQLLSPTKAGPRK 1 4.2 0.44142 0.19353 0 0 0 0 0 8.57769 0 0 0 0 0 0 Q8TBP6 S2540_HUMAN Mitochondrial glutathione transporter SLC25A40 (Mitochondrial carrier family protein) (Solute carrier family 25 member 40) SLC25A40 MCFP Homo sapiens (Human) erythrocyte development [GO:0048821]; import into the mitochondrion [GO:0170036] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] glutathione transmembrane transporter activity [GO:0034634] MQSKKFSYVELHR 1 3.8 0.86563 -0.090411 0 0 0 0 0 0 0 0 0 5.93097 0 0 Q8TBR4 ST3L4_HUMAN Putative STAG3-like protein 4 (Stromal antigen 3-like protein 4) STAG3L4 Homo sapiens (Human) LESLLEKHK 1 6 0.9804 -1.5501 0 0 0 0 8.44493 0 0 0 0 0 0 0 Q8TBR7 TLC3A_HUMAN TLC domain-containing protein 3A (Protein CT120) (Protein FAM57A) TLCD3A FAM57A Homo sapiens (Human) lipid homeostasis [GO:0055088] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] TDCVMISTR 1 3.5 0.91009 -0.28008 0 0 0 0 0 0 0 0 0 0 9.06134 0 Q8TBX8 PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) PIP4K2C PIP5K2C Homo sapiens (Human) "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]" autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] NLRDRFGIDDQDYLVSLTR 1 4.5 0.85011 -0.078895 0 0 0 0 0 0 0 10.1158 0 0 0 0 Q8TBY0 RBM46_HUMAN Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46) RBM46 Homo sapiens (Human) "cell cycle switching, mitotic to meiotic cell cycle [GO:0051728]; female meiotic nuclear division [GO:0007143]; male meiotic nuclear division [GO:0007140]; mRNA stabilization [GO:0048255]; oogenesis [GO:0048477]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]; trophectodermal cell differentiation [GO:0001829]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] CIDGASIEVTLAKPVNK;VTEGVVDVIVYPSATDKTK;VTEGVVDVIVYPSATDKTKNR 3 7.1 0.78082 0.032602 0 0 0 0 0 0 0 11.2038 0 0 8.44497 0 Q8TBY8 PMFBP_HUMAN Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) PMFBP1 Homo sapiens (Human) gene expression [GO:0010467]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of protein localization [GO:0032880]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm head-tail coupling apparatus [GO:0120212] AQLEEEIIAYEER;EEAALAGCHLEDTQRK;GLLLDKQKADTIQELQR;KDEAGERDR;LAGEAPAAQQAAQCK;LYRGNDQIMTNLEQWAKQQK;TVAEQDMK;VELEAVSEQKR 8 10.7 0.97677 -2.1916 11.9398 6.48831 0 0 5.08996 0 8.62728 7.29893 0 0 7.22052 0 Q8TBY9 CF251_HUMAN Cilia- and flagella-associated protein 251 (WD repeat-containing protein 66) CFAP251 WDR66 Homo sapiens (Human) cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317] axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] NGQRVWEYLAR;SFTVAVYMLVVR;TGEEEGEEEGK 3 3 0.94432 -0.63501 5.0613 9.84604 0 6.76261 0 0 0 4.75173 0 0 0 0 Q8TBZ0 CC110_HUMAN Coiled-coil domain-containing protein 110 (Cancer/testis antigen 52) (CT52) (Cancer/testis antigen KM-HN-1) CCDC110 KMHN1 Homo sapiens (Human) cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ILLENYVRSIENERDTLEFEMR;TLEEKNIQLSLEK;VETYEKQLK 3 5.3 0.97847 -2.0735 0 0 0 0 0 9.31673 0 0 0 0 6.2354 8.40037 Q8TBZ2 MYBPP_HUMAN MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) MYCBPAP AMAP1 Homo sapiens (Human) cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; spermatogenesis [GO:0007283] clathrin vesicle coat [GO:0030125]; cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202] clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] EEKRPPWAPPPQHNFLK;GTGCCGR;SLKKDSR 3 3.2 0.97979 -1.5386 0 10.6111 0 0 0 0 11.8385 0 11.6524 4.86012 0 0 Q8TBZ3 WDR20_HUMAN WD repeat-containing protein 20 (Protein DMR) WDR20 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deubiquitinase activator activity [GO:0035800] ATEGGGK;KETSKLFNEER;LIDKSRVTCVK;LLPHSEYSRPNR;TKTDPAKTLGTPLCPR 5 10 0.97435 -2.4437 0 0 0 0 0 9.77353 0 10.7087 0 8.3805 0 9.86819 Q8TBZ5 ZN502_HUMAN Zinc finger protein 502 ZNF502 Homo sapiens (Human) positive regulation by host of viral process [GO:0044794]; regulation of DNA-templated transcription [GO:0006355]; viral release from host cell [GO:0019076] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EIAESCLFQEGGFGRITFIHK;LYKCSECEK;SSFLVQHQR 3 7.2 0.97862 -2.1096 0 0 0 0 0 0 0 0 0 0 6.90569 8.8398 Q8TBZ6 TM10A_HUMAN tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) TRMT10A RG9MTD2 Homo sapiens (Human) tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049] NMDENDK;QIQRCYAENR 2 5 0.95266 -0.76724 0 0 0 0 0 0 0 0 5.46862 0 4.64616 0 Q8TBZ8 ZN564_HUMAN Zinc finger protein 564 ZNF564 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] CKVCGRAFIFPSYVR 1 2.7 0.84981 -0.079145 0 0 0 0 0 0 0 0 0 0 4.85135 0 Q8TC05 MDM1_HUMAN Nuclear protein MDM1 MDM1 Homo sapiens (Human) negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634] microtubule binding [GO:0008017] EPKLRNDLR;ETAPAFAANQVFHNK;QPGEKEEEDDNEEEGDR;VQGTHFSR 4 6.9 0.95203 -0.70818 11.2711 0 9.08417 0 0 0 0 0 0 6.44705 0 0 Q8TC07 TBC15_HUMAN TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) TBC1D15 Homo sapiens (Human) regulation of GTPase activity [GO:0043087] cytoplasm [GO:0005737]; extracellular region [GO:0005576] GTPase activator activity [GO:0005096] SISQEQEK;SLIEKDVNR 2 2.5 0.97816 -1.9471 0 0 0 0 0 0 0 0 0 0 0 11.7342 Q8TC12 RDH11_HUMAN Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1) RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82 Homo sapiens (Human) cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917] "11-cis-retinol dehydrogenase activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" MVELMFPLLLLLLPFLLYMAAPQIRK 1 8.2 0.37567 0.22364 0 0 0 4.55557 0 0 0 0 0 0 0 0 Q8TC20 CAGE1_HUMAN Cancer-associated gene 1 protein (CAGE-1) (Cancer/testis antigen 3) (CT3) CAGE1 CTAG3 Homo sapiens (Human) ATASALDLLK;FWSSPSDPVHFEVDTSHEK;LEKENLEER;NDKEMLQLQFK;SRLEKLLTQVR;VSDIMLQK 6 8.8 0.97514 -4.0474 10.536 0 0 13.3146 5.64677 0 0 0 0 14.3147 10.5295 0 Q8TC21 ZN596_HUMAN Zinc finger protein 596 ZNF596 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFSKCSYLRQHER;GTSTISTMR 2 4.4 0.98087 -1.6941 0 0 0 0 0 0 0 0 0 10.625 0 0 Q8TC41 RN217_HUMAN E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217) RNF217 C6orf172 IBRDC1 OSTL Homo sapiens (Human) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] TEGCDHMTCSQCNTNFCYR 1 3.5 0.65936 0.16907 8.31556 0 6.29774 0 7.82579 6.63755 8.41498 0 0 7.66938 7.01402 0 Q8TC44 POC1B_HUMAN POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) POC1B WDR51B Homo sapiens (Human) acrosome assembly [GO:0001675]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; homeostasis of number of cells [GO:0048872]; retina homeostasis [GO:0001895]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] FLYSLYRHTHWVR;LIVSCSEDK;LTLTEDKLKDCLENQQK;QLATASWDTFLMLWNFKPHAR;SIKVWSMYRQR 5 14.9 0.95549 -0.79218 0 0 0 7.76845 0 9.58855 0 10.4183 0 0 6.48978 8.97937 Q8TC56 GAR3_HUMAN Golgi-associated RAB2 interactor protein 3 GARIN3 FAM71B HSD-51 HSD51 Homo sapiens (Human) Cajal body [GO:0015030]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] EKGYSNVRGK;MVEKQNIEAK;RPVKTLELTRLLPLK;SLVAAELHR;TLELTRLLPLKFVK 5 7.8 0.95222 -0.7539 0 5.58487 0 10.016 0 0 0 9.81919 3.04757 0 10.253 0 Q8TC59 PIWL2_HUMAN Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80) PIWIL2 HILI Homo sapiens (Human) germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of circadian rhythm [GO:0042754]; oogenesis [GO:0048477]; piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of meiosis I [GO:0060903]; regulatory ncRNA-mediated gene silencing [GO:0031047]; rhythmic process [GO:0048511]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by mRNA destabilization [GO:0141008]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]; perinucleolar chromocenter [GO:0010370]; PET complex [GO:1990923]; pi-body [GO:0071546] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] IEGRVLPMERINLK 1 1.4 0.86889 -0.090713 0 0 0 0 0 0 0 0 0 0 0 2.81478 Q8TC71 MIEAP_HUMAN Mitochondria-eating protein (Spermatogenesis-associated protein 18) SPATA18 MIEAP Homo sapiens (Human) DNA damage response [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by internal vacuole formation [GO:0035695]; positive regulation of cardiolipin metabolic process [GO:1900210] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] cardiolipin binding [GO:1901612]; identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693] AMNVNPK;CRSRSLSPICPR 2 3.5 0.95251 -0.74211 0 0 0 0 0 0 0 0 0 9.51471 0 0 Q8TC84 FANK1_HUMAN Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893] chromatin [GO:0000785]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AVSVNDEDLLVRILQGGR;LVKILVSNGTDVNLKNGSGK;VTHHSIELYWDLEK 3 15.1 0.78438 0.020269 0 0 4.38094 14.9472 15.1276 15.1284 17.4509 0 17.6183 15.9348 15.6545 12.2582 Q8TC92 ENOX1_HUMAN Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX1 PIG38 Homo sapiens (Human) ultradian rhythm [GO:0007624] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] NADH dehydrogenase activity [GO:0003954]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723] DDFYEWECK;LGSSTDK 2 2.5 0.91047 -0.32598 0 0 0 3.80735 0 0 0 0 0 0 0 0 Q8TC94 ACTL9_HUMAN Actin-like protein 9 ACTL9 ACTL7C HSD21 Homo sapiens (Human) acrosome assembly [GO:0001675]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; fertilization [GO:0009566]; single fertilization [GO:0007338] acrosomal vesicle [GO:0001669]; actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; perinuclear theca [GO:0033011]; sperm head [GO:0061827]; synapse [GO:0045202] protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] EQARPEQEYK;EQARPEQEYKR;EQYEEQGPYIVYRKCY 3 6.5 0.92778 -0.4577 0 0 0 0 0 0 8.6422 0 0 3.67672 7.92291 0 Q8TC99 FNDC8_HUMAN Fibronectin type III domain-containing protein 8 FNDC8 Homo sapiens (Human) nucleus [GO:0005634] GLPLASK;LSFSPMAK 2 4.6 0.88939 -0.2071 0 0 12.7598 0 0 0 0 0 0 0 0 0 Q8TCA0 LRC20_HUMAN Leucine-rich repeat-containing protein 20 LRRC20 UNQ2429/PRO4989 Homo sapiens (Human) ELHLEGNFLHR 1 6 0.78407 0.020493 0 0 0 0 0 0 0 0 10.9207 0 0 0 Q8TCC3 RM30_HUMAN "Large ribosomal subunit protein uL30m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30)" MRPL30 MRPL28 RPML28 HSPC249 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] HLIRIKPLK;LVVQWPPGR;VVKHLIRIKPLK 3 13 0.96728 -1.3117 12.0591 0 0 0 0 0 0 11.3387 0 4.54659 0 0 Q8TCC7 S22A8_HUMAN Organic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8) SLC22A8 OAT3 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; prostaglandin transport [GO:0015732]; response to toxic substance [GO:0009636]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; solute:inorganic anion antiporter activity [GO:0005452]; xenobiotic transmembrane transporter activity [GO:0042910] VAVFNGK 1 1.3 0.90945 -0.31355 0 0 0 0 0 0 0 0 11.7625 0 0 8.36238 Q8TCD5 NT5C_HUMAN "5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)" NT5C DNT1 UMPH2 Homo sapiens (Human) allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; dCMP catabolic process [GO:0006249]; dephosphorylation [GO:0016311]; dGMP catabolic process [GO:0046055]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; IMP catabolic process [GO:0006204]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; UMP catabolic process [GO:0046050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] 5'-nucleotidase activity [GO:0008253]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103] LLSWSDNWREILDSK;RRLLSWSDNWR;YHHCVGEK 3 12.4 0.95524 -0.80637 0 0 6.6319 0 10.0249 0 0 10.6487 0 0 0 0 Q8TCD5 NT5C_HUMAN "5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)" NT5C DNT1 UMPH2 Homo sapiens (Human) allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; dCMP catabolic process [GO:0006249]; dephosphorylation [GO:0016311]; dGMP catabolic process [GO:0046055]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; IMP catabolic process [GO:0006204]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; UMP catabolic process [GO:0046050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] 5'-nucleotidase activity [GO:0008253]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103] EMNDLPDPLLKYHHCVGEK;YHHCVGEK 2 16.2 0.91859 -0.43653 0 7.31732 0 0 0 0 0 0 0 0 0 0 Q8TCE6 DEN10_HUMAN DENN domain-containing protein 10 (Protein FAM45A) DENND10 FAM45A Homo sapiens (Human) endosome transport via multivesicular body sorting pathway [GO:0032509]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641] late endosome [GO:0005770] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AYLAGSIKDIVSQFGMETVILHTALMLKK;IVVYHPK 2 10.1 0.95524 -0.88207 7.42576 0 9.97785 0 0 0 0 0 0 0 0 0 Q8TCE9 PPL13_HUMAN Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14) LGALS14 PPL13 Homo sapiens (Human) apoptotic process [GO:0006915] nucleoplasm [GO:0005654] carbohydrate binding [GO:0030246] FPPASVK 1 5 0.94016 -0.58229 0 0 0 0 0 0 0 0 0 0 0 11.9656 Q8TCG1 CIP2A_HUMAN Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) CIP2A KIAA1524 Homo sapiens (Human) broken chromosome clustering [GO:0141112]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; protein homodimerization activity [GO:0042803]; protein phosphatase inhibitor activity [GO:0004864] DLQITCDSLNK;EVQNQLVDR;SIAQLIEK;TLASMLR;TLDLINK 5 4.6 0.97484 -1.3885 13.1406 0 0 0 0 0 0 10.0418 0 4.86508 7.22188 9.77212 Q8TCG2 P4K2B_HUMAN Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) PI4K2B Homo sapiens (Human) endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524] AYPFHWAWLPQAK;IAAIDNGLAFPFKHPDEWR;VGRKFHR 3 8.1 0.98073 -1.7117 0 0 0 0 0 0 0 0 1.94942 0 9.43563 11.0879 Q8TCG5 CPT1C_HUMAN "Palmitoyl thioesterase CPT1C (EC 3.1.2.22) (Carnitine O-palmitoyltransferase 1, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C) (Carnitine palmitoyltransferase I) (CPT I-C)" CPT1C CATL1 Homo sapiens (Human) carnitine metabolic process [GO:0009437]; fatty acid metabolic process [GO:0006631]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] AMPA glutamate receptor complex [GO:0032281]; axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794] acyltransferase activity [GO:0016746]; palmitoyl-(protein) hydrolase activity [GO:0008474] NPLMVNSNYYMMAARAGNAVHALLLYR 1 3.4 0.84013 -0.045996 0 0 0 0 0 0 0 8.69035 0 0 0 0 Q8TCI5 CMAP3_HUMAN Ciliary microtubule-associated protein 3 (Protein pitchfork) CIMAP3 C1orf88 PIFO Homo sapiens (Human) cilium organization [GO:0044782]; embryonic heart tube left/right pattern formation [GO:0060971]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344] ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; gamma-tubulin binding [GO:0043015]; kinesin binding [GO:0019894]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] FKNYPKDTYYPR 1 8 0.60205 0.17711 0 0 0 0 0 0 6.25388 0 0 0 0 0 Q8TCN5 ZN507_HUMAN Zinc finger protein 507 ZNF507 KIAA1084 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ISSDTADGK;SHMWKHASDQNYNYEQVNK 2 2.9 0.95418 -0.9595 4.47554 0 0 0 0 7.78346 0 0 0 0 0 0 Q8TCP9 F200A_HUMAN Protein FAM200A FAM200A C7orf38 Homo sapiens (Human) membrane [GO:0016020] ILSLSAFWIKIK;LNSAPDMR;VALSSCVPDWK 3 5.4 0.9548 -0.9513 0 0 0 0 0 0 6.75449 0 0 0 0 7.02148 Q8TCQ1 MARH1_HUMAN E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1) MARCHF1 MARCH1 RNF171 Homo sapiens (Human) antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LQMTTSER;TSSHVCCNFLNMWKK 2 8.5 0.91558 -0.33447 0 0 0 10.7498 0 10.8959 0 0 0 6.62395 0 0 Q8TCS8 PNPT1_HUMAN "Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)" PNPT1 PNPASE Homo sapiens (Human) cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion organization [GO:0007005]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cell cycle [GO:0051726]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosome [GO:0005840] 3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723] AACRYCCSCLR;FPEADPYEIIESFNVVAK;TDPEKGEIEDYR;TKPSPSQFMPLVVDYRQK;YCCSCLR 5 7.5 0.97865 -2.0926 8.91564 9.54566 0 0 4.14299 0 0 0 11.3229 9.71862 0 0 Q8TCT0 CERK1_HUMAN Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ceramide kinase activity [GO:0001729]; magnesium ion binding [GO:0000287] AGCFVCR;QQRCAVSLEPAR 2 3.5 0.95742 -1.0294 0 0 8.52896 0 0 0 0 0 0 5.50061 0 0 Q8TCT1 PHOP1_HUMAN Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) PHOSPHO1 Homo sapiens (Human) bone mineralization [GO:0030282]; bone mineralization involved in bone maturation [GO:0035630]; endochondral ossification [GO:0001958]; regulation of bone mineralization [GO:0030500] cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010] metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; phosphocholine phosphatase activity [GO:0052731]; phosphoethanolamine phosphatase activity [GO:0052732]; pyrophosphatase activity [GO:0016462] HKVLSDYLRER;LHLQQVLKSC 2 7.9 0.96637 -1.2761 0 0 0 0 0 0 11.6014 0 0 0 0 0 Q8TCT8 SPP2A_HUMAN Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) SPPL2A IMP3 PSL2 PSEC0147 Homo sapiens (Human) membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]" LPNFKSCVILLGLLLLYDVFFVFITPFITK;NGESIMVELAAGPFGNNEK 2 9.4 0.7274 0.12645 8.16138 0 0 0 0 0 0 0 0 3.81547 0 0 Q8TCT9 HM13_HUMAN Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase) HM13 H13 IMP1 PSL3 SPP MSTP086 Homo sapiens (Human) "cellular response to oxidative stress [GO:0034599]; in utero embryonic development [GO:0001701]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; signal peptide processing [GO:0006465]" cell surface [GO:0009986]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]" EEIINYEFDTK;LVFPQDLLEK 2 5.6 0.92118 -0.44438 0 0 0 0 0 0 11.0827 11.1552 10.4016 0 0 0 Q8TCU4 ALMS1_HUMAN Centrosome-associated protein ALMS1 (Alstrom syndrome protein 1) ALMS1 KIAA0328 Homo sapiens (Human) endosomal transport [GO:0016197]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of centriole replication [GO:0046599]; regulation of stress fiber assembly [GO:0051492] centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922] microtubule binding [GO:0008017] DLKQKTSSPSSFK;DLPDRHLTEDALK;DVGITFPTPSSSEAK;EKPSIFYQQSLPSSHLTEEAK;GHEIIEPGNQK;NAEEEESRVR;NLLQCESSLNHAK;RQSQKLPVDFER;SYRLRAQLYK;TLLMEAENMALKR;VSAVSGPADGK 11 3.4 0.97264 -2.7362 12.8024 8.57939 13.1881 11.6219 9.80742 0 0 0 0 12.8029 9.76024 11.0245 Q8TCU5 NMD3A_HUMAN "Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)" GRIN3A KIAA1973 Homo sapiens (Human) "calcium ion transport [GO:0006816]; dendrite development [GO:0016358]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine development [GO:0061000]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202] calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; serine binding [GO:0070905]; transmitter-gated monoatomic ion channel activity [GO:0022824]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] FLANTTFR;IYEELSGIHDPK 2 1.8 0.94594 -0.65529 0 0 0 0 0 6.09856 0 0 0 0 0 0 Q8TCU6 PREX1_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)" PREX1 KIAA1415 Homo sapiens (Human) actin filament polymerization [GO:0030041]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin filament polymerization [GO:0030833]; regulation of dendrite development [GO:0050773]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]; superoxide metabolic process [GO:0006801]; T cell differentiation [GO:0030217] cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] GLSFLLKQEDR;HLPSQCWR;LLVELNK;NEQVMYRFRYDDGTYK;SELEDIMSKGVR;VCFKVAEEDQEDSGHDTMSYRDSYSECNSNR;WFVCMAK 7 5.9 0.97237 -2.7886 11.2256 7.5985 3.5358 8.71277 0 0 9.62414 0 0 9.6886 0 7.81999 Q8TCV5 WFDC5_HUMAN WAP four-disulfide core domain protein 5 (Putative protease inhibitor WAP1) (p53-responsive gene 5 protein) WFDC5 PRG5 WAP1 UNQ3036/PRO9842 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] CCHSACGR;CCHSACGRDCR;DSDCSGK 3 14.6 0.96449 -1.1705 7.20359 0 0 0 0 0 0 0 6.54398 0 0 0 Q8TCW7 ZPLD1_HUMAN "Zona pellucida-like domain-containing protein 1 (ZP domain-containing protein 1) (Cupulin) [Cleaved into: Zona pellucida-like domain-containing protein 1, secreted form]" ZPLD1 Homo sapiens (Human) vestibular reflex [GO:0060005] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615] FVKHKNQK 1 1.9 0.97544 -1.4712 0 0 0 0 0 0 0 0 0 0 10.9495 0 Q8TCW9 PKR1_HUMAN Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) PROKR1 GPR73 PKR1 Homo sapiens (Human) circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] SSADLDLK 1 2 0.74421 0.10231 0 0 0 0 0 0 0 0 0 7.50811 0 0 Q8TCX1 DC2L1_HUMAN Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain) DYNC2LI1 D2LIC LIC3 CGI-60 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cilium assembly [GO:1902017] apical part of cell [GO:0045177]; axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514] dynein heavy chain binding [GO:0045504] GVINQLAFGIDK;LHAHSPMELWKKVYEK 2 8 0.96528 -1.2554 0 10.958 11.9926 0 0 0 0 11.1522 0 0 0 0 Q8TCX5 RHPN1_HUMAN Rhophilin-1 (GTP-Rho-binding protein 1) RHPN1 KIAA1929 Homo sapiens (Human) negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165] cytosol [GO:0005829] LSQGKGPDIFHR 1 1.8 0.96443 -1.2317 0 0 0 0 0 0 0 0 0 9.70903 0 0 Q8TCY9 URGCP_HUMAN Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) URGCP KIAA1507 URG4 Homo sapiens (Human) cytosol [GO:0005829]; nucleus [GO:0005634] GTP binding [GO:0005525] LQGDPWR;LQGDPWRK;LQGDPWRKAAQVEK;RTAVAIADLEWR;VAQPRLR;VAQPRLRQPPETLLTLRPK;YYFILSPYR 7 5.8 0.96479 -1.2502 0 0 0 0 7.08289 0 3.34554 11.7517 0 0 0 3.8746 Q8TCZ2 C99L2_HUMAN CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) CD99L2 MIC2L1 UNQ1964/PRO4486 Homo sapiens (Human) cell adhesion [GO:0007155]; diapedesis [GO:0050904]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T cell extravasation [GO:2000409] adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] APANTLGNDFDLADALDDR;DLEDIVGGGEYKPDK 2 13 0.76988 0.055453 0 0 0 0 0 0 8.0705 5.85599 0 0 0 0 Q8TD10 MIPO1_HUMAN Mirror-image polydactyly gene 1 protein MIPOL1 Homo sapiens (Human) nucleus [GO:0005634] identical protein binding [GO:0042802] AKLLSMQQARETAVQQYK;DAALSKCKR;HNDMHYECMTPCQVTSDSDK;IYKTKECK;VGTGTMR 5 14 0.89255 -0.22418 0 0 0 0 0 0 0 0 0 0 0 10.8303 Q8TD10 MIPO1_HUMAN Mirror-image polydactyly gene 1 protein MIPOL1 Homo sapiens (Human) nucleus [GO:0005634] identical protein binding [GO:0042802] AKLLSMQQARETAVQQYK;DAALSKCKR;IYKTKECK;MSRLQLAIEERDEAIAR;VGTGTMR 5 22.6 0.97324 -2.5898 8.48941 0 0 7.58782 7.23611 7.58067 7.84411 0 9.90179 0 0 0 Q8TD16 BICD2_HUMAN Protein bicaudal D homolog 2 (Bic-D 2) BICD2 KIAA0699 Homo sapiens (Human) "centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; mRNA transport [GO:0051028]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267] EAQHAEEK;EQYYVRK;LVMEAQPEWLR 3 3.2 0.96425 -1.1796 0 0 0 0 0 7.94656 0 0 0 0 10.801 0 Q8TD19 NEK9_HUMAN Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) NEK9 KIAA1995 NEK8 NERCC Homo sapiens (Human) cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; regulation of mitotic cell cycle [GO:0007346] cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGILHRDIKTLNIFLTK;EVYSWGCGEYGR;KRLGINLLGGPLGGK;LGINLLGGPLGGKQVIR 4 4.9 0.74571 0.097363 0 7.09032 0 0 4.08806 0 7.765 10.8756 0 0 0 0 Q8TD22 SFXN5_HUMAN Sideroflexin-5 SFXN5 Homo sapiens (Human) amino acid transport [GO:0006865]; citrate transport [GO:0015746]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] citrate transmembrane transporter activity [GO:0015137]; monoatomic ion transmembrane transporter activity [GO:0015075] ANKFTPATRLLIQR;FIQGYLGAVISAVSIAVGLNVLVQK 2 11.5 0.76562 0.060946 0 0 0 0 0 0 0 4.6193 0 5.69744 0 0 Q8TD23 ZN675_HUMAN Zinc finger protein 675 (TRAF6-binding zinc finger protein) (TRAF6-inhibitory zinc finger protein) ZNF675 TIZ Homo sapiens (Human) bone resorption [GO:0045453]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" AFIQSSK;AFNQFSNLTTHKK;CEECGKAFNQFSNLTTHKK;CEECGKAFNRSSK;CEECGKAFNRSSNLTEHR;VNFCKCEECEK 6 14.3 0.88972 -0.20654 0 0 0 6.96243 0 0 0 0 6.8674 8.63136 7.84222 0 Q8TD26 CHD6_HUMAN Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) CHD6 CHD5 KIAA1335 RIGB Homo sapiens (Human) cell redox homeostasis [GO:0045454]; chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription coregulator binding [GO:0001221]" HMERWMHGLENDEFEIEKPK;KYNEDLDFK;LLEGLKLMALEHK;LQSILKPMMLRR;NKQAQMK;TFDWTQFR;VEKNLLIFGWGR;WAKIAELDTEAKNEK 8 3.5 0.97524 -4.1077 0 8.58849 0 0 0 0 0 10.0527 5.93272 0 8.47788 11.9235 Q8TD30 ALAT2_HUMAN Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) GPT2 AAT2 ALT2 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170] AAALVRRGCGPR;AGEIELELQR;EDVAAYITR 3 5.9 0.97334 -2.6318 0 0 0 0 0 0 0 0 0 0 0 12.348 Q8TD43 TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) TRPM4 LTRPC4 Homo sapiens (Human) adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; sodium channel activity [GO:0005272] KLLTWESVHKENFLLAR;QLCRRPRSPQPSSPALEHFR;VLEREVQQCSR;WWGDMASTTPIWALVLAFFCPPLIYTRLITFRK 4 6.7 0.9551 -0.83283 0 0 10.6617 0 7.97005 0 0 0 7.37434 0 5.96005 0 Q8TD46 MO2R1_HUMAN Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1) CD200R1 CD200R CRTR2 MOX2R OX2R UNQ2522/PRO6015 Homo sapiens (Human) heterotypic cell-cell adhesion [GO:0034113]; intracellular signal transduction [GO:0035556]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of T cell migration [GO:2000405]; regulation of neuroinflammatory response [GO:0150077]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glycosylated region protein binding [GO:0140081]; immunoglobulin receptor activity [GO:0019763]; signaling receptor activity [GO:0038023] QEYWSNGTVTVK;QITQNYSKVLAEVNTSWPVK;SLYIELLPVPGAK 3 12.9 0.90352 -0.26575 0 0 0 0 0 7.49921 3.8749 10.1546 0 0 0 0 Q8TD46 MO2R1_HUMAN Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1) CD200R1 CD200R CRTR2 MOX2R OX2R UNQ2522/PRO6015 Homo sapiens (Human) heterotypic cell-cell adhesion [GO:0034113]; intracellular signal transduction [GO:0035556]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of T cell migration [GO:2000405]; regulation of neuroinflammatory response [GO:0150077]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glycosylated region protein binding [GO:0140081]; immunoglobulin receptor activity [GO:0019763]; signaling receptor activity [GO:0038023] QITQNYSKVLAEVNTSWPVK;YFTSPDL 2 16.4 0.91489 -0.33057 0 0 0 0 0 0 0 6.8658 0 0 0 0 Q8TD57 DYH3_HUMAN Dynein axonemal heavy chain 3 (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b) DNAH3 DNAHC3B Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AELPDNLK;CIRLWIHEVYR;EVMTTEEMK;IIQIYEMMLVR;LLFSLLLTIGIMKQKK;LVMESICIMKGMKPER;MKLDWVNVTFSFVK;QSGGSGK;SIVDYILMDPMERKR;TLLNSKR;TLSDVPAPR;TSWTLAAPFK;VEVVSMCK;WALMIDPHGQANKWIK 14 3.8 0.97545 -3.3509 0 14.559 13.6528 10.7728 7.71905 8.17108 14.4278 8.91964 0 10.7674 8.31981 10.4524 Q8TD57 DYH3_HUMAN Dynein axonemal heavy chain 3 (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b) DNAH3 DNAHC3B Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] LEFLMDYADLPYEDIK;SIVDYILMDPMERKR;TSWTLAAPFK 3 5.4 0.77153 0.054974 0 0 0 0 0 0 0 0 0 10.2692 0 0 Q8TD84 DSCL1_HUMAN Cell adhesion molecule DSCAML1 (Down syndrome cell adhesion molecule 2) (Down syndrome cell adhesion molecule-like protein 1) DSCAML1 DSCAM2 KIAA1132 Homo sapiens (Human) axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] axon [GO:0030424]; cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803] DAKSLAEMLISK;EATWYELR;GAPPPTVTWALDDEPIVR;IRSPNIR;NVAVPIPHRANK;SMRGNVAVFKCLIPSSVQEYVSVVSWEK;VELRGMEK 7 4.5 0.97856 -6.6987 0 0 14.4493 0 0 7.53799 12.4464 0 0 0 0 12.4429 Q8TD90 MAGE2_HUMAN Melanoma-associated antigen E2 (Hepatocellular carcinoma-associated protein 3) (MAGE-E2 antigen) MAGEE2 HCA3 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] ASLLALVLGHILLNGNRAR 1 3.6 0.82572 -0.020514 0 6.77492 0 0 0 0 9.8266 0 0 0 0 0 Q8TD91 MAGC3_HUMAN Melanoma-associated antigen C3 (Cancer/testis antigen 7.2) (CT7.2) (Hepatocellular carcinoma-associated antigen 2) (MAGE-C3 antigen) MAGEC3 HCA2 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] AEMLTTVIKKYK;LLILILSVIFIK;LVQFLLLKYQAK;RTLWKDSDLPTWR 4 7.6 0.78214 0.0219 0 2.35862 0 3.04827 0 0 9.95216 9.90078 3.14535 7.1375 7.34181 0 Q8TDB6 DTX3L_HUMAN E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; metal ion binding [GO:0046872]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842] AFDQKLIFTVGYSRVLGVSDVITWNDIHHK;ISEAFVK;NTEPLKQECVSLADSK;TAYLPDNK;VLPKCKHEFCAPCINK 5 10.4 0.9704 -1.3343 0 0 0 0 0 0 10.5127 12.3965 10.4074 0 0 9.33401 Q8TDB8 GTR14_HUMAN "Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)" SLC2A14 GLUT14 Homo sapiens (Human) cell differentiation [GO:0030154]; D-glucose import [GO:0046323]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; spermatogenesis [GO:0007283] aggresome [GO:0016235]; nucleus [GO:0005634]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300] IAESVEMLILGR;LWGTQDVSQDIQEMKDESARMSQEK;QVTVLELFR;TFEDITR 4 10.2 0 2.0106 12.6067 11.9583 12.659 9.78202 9.73639 0 0 0 0 0 10.6215 0 Q8TDD1 DDX54_HUMAN ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) DDX54 Homo sapiens (Human) estrogen receptor signaling pathway [GO:0030520]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714] DVVAMARTGSGK;LQSVEYVVFDEADR 2 3 0.97826 -2.1514 0 0 0 0 0 9.78557 0 0 0 0 0 0 Q8TDD5 MCLN3_HUMAN Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) MCOLN3 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; inner ear auditory receptor cell differentiation [GO:0042491]; locomotory behavior [GO:0007626] autophagosome membrane [GO:0000421]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; lipid binding [GO:0008289]; monoatomic anion channel activity [GO:0005253]; NAADP-sensitive calcium-release channel activity [GO:0072345]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272] YLGFFAK 1 1.3 0.60069 0.17736 0 0 0 0 0 0 0 0 0 10.2891 0 0 Q8TDF5 NETO1_HUMAN Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) NETO1 BTCL1 Homo sapiens (Human) anterograde axonal transport of neurotransmitter receptor complex [GO:0140231]; memory [GO:0007613]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of excitatory postsynaptic potential [GO:2000463]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; visual learning [GO:0008542] axon cytoplasm [GO:1904115]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] ionotropic glutamate receptor binding [GO:0035255] SVLHIVASLIILHLSGATKK 1 3.8 0.57807 0.18087 0 0 0 0 0 0 0 0 0 0 4.14592 0 Q8TDF6 GRP4_HUMAN RAS guanyl-releasing protein 4 RASGRP4 Homo sapiens (Human) antibacterial innate immune response [GO:0140367]; myeloid cell differentiation [GO:0030099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of natural killer cell mediated immunity [GO:0002717]; Ras protein signal transduction [GO:0007265] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085] IGGRGRPRQVR 1 1.6 0.97945 -1.5445 0 0 0 0 0 9.12766 0 0 0 9.44642 0 0 Q8TDG2 ACTT1_HUMAN Actin-related protein T1 (ARP-T1) ACTRT1 ARPT1 HSD27 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] chromatin binding [GO:0003682] EKLCYIALEPEK;YEALHLHYPIERGLVTGWDDMEKLWK 2 10.1 0.94521 -0.64381 0 12.5587 0 0 0 0 0 0 0 0 0 0 Q8TDG4 HELQ_HUMAN Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) HELQ HEL308 Homo sapiens (Human) DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; positive regulation of double-strand break repair via homologous recombination [GO:1905168] nucleus [GO:0005634]; site of DNA damage [GO:0090734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ALLVELTK;KLTYCVK 2 1.4 0.95205 -0.74496 0 0 0 0 0 0 0 7.74281 0 0 0 0 Q8TDG4 HELQ_HUMAN Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) HELQ HEL308 Homo sapiens (Human) DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; positive regulation of double-strand break repair via homologous recombination [GO:1905168] nucleus [GO:0005634]; site of DNA damage [GO:0090734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ELTSFIAFVYFSRLR 1 11 0.817 -0.016925 0 0 0 0 0 0 10.343 0 0 0 0 0 Q8TDI0 CHD5_HUMAN Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) CHD5 KIAA0444 Homo sapiens (Human) cerebral cortex neuron differentiation [GO:0021895]; chromatin remodeling [GO:0006338]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092] chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; H3K27me3 modified histone binding [GO:0061628]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] AAVSSGK;DDDDEEEEGGCEEEEDDHMEFCRVCK;DEDEDDNDDGCLK;EEDDEGKKEDK;EEDGVEEVEREIIK;FFRVLNSYKIDYK;ILDKLELSLIHSR;ILNHSFDK;LTNRAGDPTIQQGAFGSSQMYSNNFGPNFR;VELSQMQKKYYK 10 7.5 0.97597 -4.5876 0 0 0 0 0 12.215 0 6.55408 10.9625 5.91397 7.6034 5.40224 Q8TDI7 TMC2_HUMAN Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) TMC2 C20orf145 UNQ907/PRO1928 Homo sapiens (Human) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] cuticular plate [GO:0032437]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] calcium channel activity [GO:0005262]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] ATARDSEDTPKSSSK;LANEETIK 2 2.5 0.9214 -0.43971 0 0 11.3843 0 0 8.84376 0 0 0 0 0 0 Q8TDI7 TMC2_HUMAN Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) TMC2 C20orf145 UNQ907/PRO1928 Homo sapiens (Human) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] cuticular plate [GO:0032437]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] calcium channel activity [GO:0005262]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] CRVSVAREHLPSR 1 8 0.76948 0.057856 0 0 0 0 0 0 0 0 0 8.43659 0 0 Q8TDI8 TMC1_HUMAN Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) TMC1 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] external side of plasma membrane [GO:0009897]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] calcium channel activity [GO:0005262]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] TIGWMNFR 1 1.1 0.91456 -0.39033 0 0 0 0 0 0 0 0 0 0 0 9.75136 Q8TDJ6 DMXL2_HUMAN DmX-like protein 2 (Rabconnectin-3) DMXL2 KIAA0856 Homo sapiens (Human) vacuolar acidification [GO:0007035] extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] small GTPase binding [GO:0031267] CCMEANPECNK;ETVTVGK;GLHMKLDHDLSLDR;LSVPMPLPTVLLDR;TSALSAKKDQPDFISHR 5 2.1 0.9772 -1.4944 0 0 8.1875 0 0 0 5.90675 10.8764 0 9.9043 0 0 Q8TDM0 BCAS4_HUMAN Breast carcinoma-amplified sequence 4 BCAS4 Homo sapiens (Human) BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737] EVEETIEGMLLRLEEFCSLADLIR 1 11.4 0.83597 -0.034544 0 0 11.908 0 0 0 0 0 0 0 0 0 Q8TDM5 SACA4_HUMAN Sperm acrosome membrane-associated protein 4 (Sperm acrosomal membrane-associated protein 14) SPACA4 SAMP14 UNQ3046/PRO9862 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fertilization [GO:0009566]; sperm-egg recognition [GO:0035036] extracellular region [GO:0005576]; inner acrosomal membrane [GO:0002079]; membrane [GO:0016020]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] GVTYSLTTNCCTGRLCNR 1 14.5 0.92192 -0.44207 0 0 0 7.3799 0 0 0 0 0 0 0 0 Q8TDM6 DLG5_HUMAN Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) DLG5 KIAA0583 PDLG Homo sapiens (Human) apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; metanephric collecting duct development [GO:0072205]; midbrain development [GO:0030901]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of T cell proliferation [GO:0042130]; neuroepithelial cell differentiation [GO:0060563]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of hippo signaling [GO:0035332]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of synapse assembly [GO:0051965]; postsynapse organization [GO:0099173]; protein localization to adherens junction [GO:0071896]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; zonula adherens assembly [GO:0045186] adherens junction [GO:0005912]; cell junction [GO:0030054]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] beta-catenin binding [GO:0008013]; cytoskeletal protein binding [GO:0008092]; signaling receptor complex adaptor activity [GO:0030159] ALLNGEGAINMVVRR;ATHGSNSLPSSAR;DWAFQERDK;EALQEADVAK;GGIYVSK;GSEPLGISIVSGEK;GVKDCLFVDYK;IQRGQIPSK;LHHMHIYPIVIFIHYK;LNPDYERLK;LSMSEVK;LSVYKKPKQR;NLIQHNNSTQTDIFYTDRLEDRK;SAPSFRPK 14 8.4 0.97692 -5.6947 10.2709 0 10.0542 0 6.46192 8.16511 6.13752 0 9.35837 7.84944 11.1769 10.192 Q8TDN2 KCNV2_HUMAN Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2) KCNV2 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] GEVNFMQR;VMRLMRIFR 2 3.1 0.9781 -2.062 0 10.9897 0 0 0 0 0 0 0 8.4778 0 0 Q8TDN4 CABL1_HUMAN CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) CABLES1 CABLES Homo sapiens (Human) cell division [GO:0051301]; nervous system development [GO:0007399]; regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; nucleus [GO:0005634] KPRMDPR;LTLSKIR 2 2.2 0.98081 -1.6259 0 0 0 0 0 0 0 0 0 10.3996 0 0 Q8TDP1 RNH2C_HUMAN Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) RNASEH2C AYP1 Homo sapiens (Human) mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401] nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299] FIGATANFSR;MESGDEAAIERHR 2 14 0.95577 -0.84095 6.1888 0 0 0 0 0 0 0 9.02381 0 0 0 Q8TDQ0 HAVR2_HUMAN Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366) HAVCR2 TIM3 TIMD3 Homo sapiens (Human) adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of gene expression [GO:0010629]; negative regulation of granulocyte colony-stimulating factor production [GO:0071656]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-3 production [GO:0032712]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of macrophage activation [GO:0043032]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of tolerance induction dependent upon immune response [GO:0002652]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] anchoring junction [GO:0070161]; cell surface [GO:0009986]; early endosome [GO:0005769]; immunological synapse [GO:0001772]; mediator complex [GO:0016592] metal ion binding [GO:0046872] LVIKPGEWTFACHLYE 1 11.3 0.55096 0.18341 0 0 0 0 0 0 0 0 0 0 0 9.85832 Q8TDQ1 CLM1_HUMAN CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f) CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111 Homo sapiens (Human) immune response-activating signaling pathway [GO:0002757]; interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of mast cell activation [GO:0033004]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] plasma membrane [GO:0005886] ceramide binding [GO:0097001]; identical protein binding [GO:0042802]; interleukin-4 receptor binding [GO:0005136]; phosphatidylserine binding [GO:0001786] GAIWRDCK 1 2.8 0.91303 -0.33804 0 0 0 0 0 0 0 0 0 0 0 10.4125 Q8TDQ7 GNPI2_HUMAN Glucosamine-6-phosphate deaminase 2 (GlcN6P deaminase 2) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 2) (Glucosamine-6-phosphate isomerase SB52) GNPDA2 GNP2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853] MDEYVGLPR 1 4.4 0.92788 -0.45728 0 0 0 0 0 0 0 0 10.3939 0 0 0 Q8TDR0 MIPT3_HUMAN TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3) TRAF3IP1 IFT54 MIPT3 Homo sapiens (Human) cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of defense response to virus [GO:0050687]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type I interferon production [GO:0032480]; regulation of microtubule cytoskeleton organization [GO:0070507] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] microtubule binding [GO:0008017] EDRKPREK;GRASLTSR;IVAGHEPER;LLSKPPFR;NVREEESRVHK;SLTTKTSK;SQELDNKNVREEESR;TSIQTLCK;VLAGEKGEVK 9 11.1 0.97586 -4.4394 0 14.4608 4.29138 0 0 0 5.37705 10.2121 0 7.88746 11.2167 0 Q8TDR2 STK35_HUMAN Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) STK35 CLIK1 PDIK1 STK35L1 Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVETSLK 1 1.3 0.8897 -0.20874 16.4299 0 0 0 0 0 0 0 0 0 0 0 Q8TDR4 TCP1L_HUMAN T-complex protein 10A homolog 1 (T-complex protein 10A-1) (TCP10A-1) (TCP10-like) TCP10L PRED77 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] EKLRALQLQR 1 4.7 0.97583 -1.4621 0 0 0 0 3.88284 0 0 0 0 9.43794 10.3891 10.3593 Q8TDS4 HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor) HCAR2 GPR109A HCA2 HM74A NIACR1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995]; neutrophil apoptotic process [GO:0001781]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of neutrophil apoptotic process [GO:0033031] cell junction [GO:0030054]; plasma membrane [GO:0005886] nicotinic acid receptor activity [GO:0070553] AITFIMVVAIVFVICFLPSVVVRIR 1 6.9 0.83819 -0.039211 0 0 0 0 0 5.34472 0 0 0 0 0 0 Q8TDS5 OXER1_HUMAN Oxoeicosanoid receptor 1 (5-oxo-ETE G-protein coupled receptor) (G-protein coupled receptor 170) (G-protein coupled receptor R527) (G-protein coupled receptor TG1019) OXER1 GPR170 TG1019 Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050648]; 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050647]; 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050646]; G protein-coupled receptor activity [GO:0004930]" NRGLGGQAGPQRAMR;QWRYREASR;VQGEVSLEKEGSSQG 3 10.2 0.97825 -1.9304 0 0 4.67022 0 9.78839 0 0 0 9.65703 0 0 1.58804 Q8TDS7 MRGRD_HUMAN Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7) MRGPRD MRGD Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] extracellular space [GO:0005615]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRR 1 10.3 0.96357 -1.1098 0 0 8.68853 0 0 0 0 0 0 0 0 0 Q8TDT2 GP152_HUMAN Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5) GPR152 PGR5 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802] VARTILSAYVVLR 1 2.8 0.92394 -0.4496 0 0 0 0 0 0 4.28969 0 0 0 0 0 Q8TDV0 GP151_HUMAN G-protein coupled receptor 151 (G-protein coupled receptor PGR7) (GPCR-2037) (Galanin receptor 4) (Galanin-receptor-like protein) (GalRL) GPR151 GALR4 GALRL PGR7 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of immune response [GO:0050778]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931] cholinergic synapse [GO:0098981]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188] VCFMYASDPAK 1 2.6 0.80479 0.014082 0 0 0 0 0 5.85788 0 0 0 0 0 0 Q8TDW0 LRC8C_HUMAN Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) LRRC8C AD158 FAD158 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fat cell differentiation [GO:0045444]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; taurine transmembrane transport [GO:0015734] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] ALHWYAK;EGEQAKALFEK;ENLKVLSVKFDDMR;VESLPDELYFCK 4 5.5 0.91346 -0.38705 0 8.67154 0 0 0 0 0 0 0 0 10.6937 9.64739 Q8TDW4 ST7L_HUMAN Suppressor of tumorigenicity 7 protein-like (ST7-related protein) ST7L ST7R Homo sapiens (Human) negative regulation of cell growth [GO:0030308] membrane [GO:0016020] LAMCARK;LAMCARKLGR 2 1.7 0.95524 -0.81911 8.33851 0 0 0 0 0 0 0 0 0 0 0 Q8TDW5 SYTL5_HUMAN Synaptotagmin-like protein 5 SYTL5 SLP5 Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267] ASHDGPK;FKQVNVLGTDVVR;IAQLRIITGEWFFEEKAK;IITGEWFFEEK;NCRNLAIGDEK;RSGKTQQEASR;SPGAEEVQSQEQTR 7 10.1 0.97491 -2.3804 0 0 10.5594 0 9.8993 8.48539 9.70893 0 0 5.47239 9.6609 7.92541 Q8TDW7 FAT3_HUMAN Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3) FAT3 CDHF15 KIAA1989 Homo sapiens (Human) cell morphogenesis involved in neuron differentiation [GO:0048667]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842] dendrite [GO:0030425]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ANYSLKIEARDK;EQQSSYNISVR;IGTSVLQVTARDEDSGR;INPRSGLIVTARPLNTVK;LEVTNKEGDLK;MLDHELVQHCTLK;TGLITTTSRKLDR;TGMVSSR;TLALLDR;VAATIPLDK;VNSHDGK;VTDINDNAPVFAQEVYR 12 3.1 0.97692 -5.6486 9.56018 0 0 6.43724 8.88353 4.58622 0 12.9929 0 8.2784 13.0962 10.7697 Q8TDX5 ACMSD_HUMAN 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Homo sapiens (Human) negative regulation of quinolinate biosynthetic process [GO:1904985]; picolinic acid biosynthetic process [GO:1905004]; regulation of 'de novo' NAD biosynthetic process from tryptophan [GO:1905012]; secondary metabolic process [GO:0019748]; tryptophan catabolic process [GO:0006569] cytoplasm [GO:0005737]; cytosol [GO:0005829] aminocarboxymuconate-semialdehyde decarboxylase activity [GO:0001760]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] DKVILGTDYPFPLGELEPGK;LIESMEEFDEETK 2 9.8 0.90859 -0.27608 0 0 0 0 7.65148 0 0 0 4.53717 0 0 0 Q8TDX7 NEK7_HUMAN Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NEK7 Homo sapiens (Human) cellular response to potassium ion [GO:0035865]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] YFVQLCSALEHMHSRRVMHR 1 6.6 0.46265 0.19077 0 0 7.21636 0 0 0 0 9.53508 0 0 0 0 Q8TDX9 PK1L1_HUMAN Polycystin-1-like protein 1 (Polycystin-1L1) (PC1-like 1 protein) (Polycystic kidney disease protein 1-like 1) PKD1L1 PC1L1 UNQ5785/PRO19563 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986] calcium channel complex [GO:0034704]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730] calcium channel activity [GO:0005262] KPRNWLEVASLVSFSFEK;LSKEAPGSAR;LSKEDKTASCNQWSR;TEAHTALSR 4 2 0.97824 -1.5084 0 0 0 0 0 0 0 11.9046 12.4469 8.95702 9.93511 0 Q8TDY2 RBCC1_HUMAN RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) RB1CC1 KIAA0203 RBICC Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; glycophagy [GO:0061723]; heart development [GO:0007507]; innate immune response [GO:0045087]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709]; ribophagy [GO:0034517] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-membrane adaptor activity [GO:0043495] AIKGLEDR;LQEEKAK;TQLALEMYEVAKK 3 1.8 0.97465 -2.4025 6.38679 0 0 0 0 0 5.63169 0 0 0 0 0 Q8TDY3 ACTT2_HUMAN Actin-related protein T2 (ARP-T2) (Actin-related protein M2) ACTRT2 ARPM2 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] KLCYVALEPEK 1 2.9 0.7326 0.11533 0 0 0 0 0 0 0 0 0 12.6378 0 0 Q8TDY4 ASAP3_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)" ASAP3 DDEFL1 UPLC1 Homo sapiens (Human) cell migration [GO:0016477]; positive regulation of GTPase activity [GO:0043547]; regulation of stress fiber assembly [GO:0051492] cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] GQLRDGR 1 0.8 0.98077 -1.5944 0 0 0 0 0 0 0 0 9.10308 0 0 0 Q8TDY8 IGDC4_HUMAN Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) cell-cell adhesion [GO:0098609] plasma membrane [GO:0005886] SALSRSSLER;SPVSSSA 2 1.7 0.97369 -1.403 0 7.21199 0 0 0 0 7.57168 0 0 8.90749 0 12.1846 Q8TDZ2 MICA1_HUMAN [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) MICAL1 MICAL NICAL Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of regulated secretory pathway [GO:1903305]; signal transduction [GO:0007165]; sulfur oxidation [GO:0019417] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; intermediate filament [GO:0005882]; midbody [GO:0030496]; plasma membrane [GO:0005886] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]" AGQPVYQQGR;AVTPNQVRDLYDVLAKEPVQR;LSSPERQR 3 3.7 0.98059 -1.6603 0 10.5864 0 0 7.17453 0 0 0 8.56898 0 0 0 Q8TE04 PANK1_HUMAN Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) PANK1 PANK Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; recycling endosome [GO:0055037] acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803] FIQMGSEK;LVYFEPK;VTGTSFGNMMSKEK 3 9.2 0.96013 -1.0532 0 0 0 9.28953 0 0 0 0 0 0 0 12.064 Q8TE12 LMX1A_HUMAN LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A) LMX1A Homo sapiens (Human) axon guidance [GO:0007411]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; dopaminergic neuron differentiation [GO:0071542]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; olfactory behavior [GO:0042048]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse organization [GO:0050808] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GTAEEGKDHK;SAHGAGK;SVYHLSCFCCCVCER;VVQVWFQNQRAKMK 4 12 0.97318 -2.9441 0 0 9.13563 0 0 9.30355 10.0121 10.2992 10.4858 0 0 7.03628 Q8TE23 TS1R2_HUMAN Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) TAS1R2 GPR71 T1R2 TR2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; sensory perception of sweet taste [GO:0050916] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sweet taste receptor complex [GO:1903767] G protein-coupled receptor activity [GO:0004930]; sweet taste receptor activity [GO:0033041]; taste receptor activity [GO:0008527] TDPDDPK 1 0.8 0.91069 -0.319 0 0 0 0 0 6.61742 0 0 0 0 0 0 Q8TE49 OTU7A_HUMAN OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2) OTUD7A C15orf16 CEZANNE2 OTUD7 Homo sapiens (Human) protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] AVPGALPGAAGTAGAAEHK;LGSFSKTLGIKLK;TVNTVESLAR 3 4.5 0.96632 -1.2721 0 0 0 0 4.08015 0 0 0 0 0 0 0 Q8TE54 S26A7_HUMAN Anion exchange transporter (Solute carrier family 26 member 7) SLC26A7 SUT2 Homo sapiens (Human) bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; gastric acid secretion [GO:0001696]; gluconate transmembrane transport [GO:0035429]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; nitrate transmembrane transport [GO:0015706]; oxalate transport [GO:0019532]; sulfate transmembrane transport [GO:1902358]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116] ELNEQFK;KSMLWSK;LEALLLSLLSIVVLVLVK;RLPILDWAPHYNLK 4 7 0.95521 -0.80543 0 0 0 0 0 5.28007 0 3.52469 0 9.08252 0 0 Q8TE56 ATS17_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AEEACEDYSGCYEWK;DDLENFLKSK;DLYLQLRRDLR;ISAKGPTK;LSIGHHGER 5 4.8 0.97547 -3.4367 0 0 0 0 0 9.66738 6.5685 11.0895 0 0 6.98539 0 Q8TE57 ATS16_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; extracellular matrix organization [GO:0030198]; male gamete generation [GO:0048232]; proteolysis [GO:0006508]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GDYVSHEIMHHQRR;MKPRARGWR;TCGGGAQSRPVQCTR 3 3.1 0.96176 -1.07 0 0 0 7.20809 0 0 7.46271 0 0 0 0 0 Q8TE58 ATS15_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-) ADAMTS15 Homo sapiens (Human) extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; proteolysis [GO:0006508] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] CGVCGGDNKSCK;HPSILNPINIVVVKVLLLRDR;LCLKGACVER;LDPDINGRR;LTLAVAWVPKYSGVSPRDK 5 7.5 0.97213 -2.7956 0 0 10.2432 0 8.94424 0 6.37105 5.24409 0 0 10.8872 0 Q8TE59 ATS19_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-) ADAMTS19 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; mitral valve morphogenesis [GO:0003183]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184]; tricuspid valve morphogenesis [GO:0003186]; ventricular septum morphogenesis [GO:0060412] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CNEQPCQTR;DCIGPKPASAQR;GVGGGGSAR;NLCQDMRWYQRCCETCR;TVRCTNPRK;VEGEKECRTK 6 5.5 0.97656 -2.2454 0 0 0 0 11.0404 0 0 9.23182 0 4.01997 5.97037 0 Q8TE60 ATS18_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GLAGLGRVAK;LITFPER;VEEEDRCKLYCK 3 2.4 0.95586 -0.84076 7.52019 0 0 0 0 0 0 0 9.94911 0 10.6496 0 Q8TE67 ES8L3_HUMAN Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) EPS8L3 EPS8R3 Homo sapiens (Human) positive regulation of ruffle assembly [GO:1900029]; regulation of hair cycle [GO:0042634]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085] ALEEELEQRPR 1 1.9 0.89802 -0.23218 0 0 0 0 0 0 0 0 11.5408 0 0 0 Q8TE68 ES8L1_HUMAN Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) EPS8L1 DRC3 EPS8R1 PP10566 Homo sapiens (Human) positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; cadherin binding [GO:0045296]; T cell receptor binding [GO:0042608] AVSPEEGAR;SIYEQRK 2 2.2 0.9655 -1.1462 9.4624 0 9.5856 0 0 0 0 0 0 0 0 0 Q8TE69 EOLA1_HUMAN Protein EOLA1 (Endothelial-overexpressed lipopolysaccharide-associated factor 1) (Endothelium and lymphocyte associated ASCH domain 1) EOLA1 CXorf40 CXorf40A Homo sapiens (Human) regulation of gene expression [GO:0010468]; regulation of interleukin-6 production [GO:0032675] mitochondrion [GO:0005739] WRPLLSSQR 1 6.2 0.9098 -0.31553 0 0 0 0 6.59662 0 0 0 0 0 0 0 Q8TE73 DYH5_HUMAN Dynein axonemal heavy chain 5 (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5) DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AELEHWKK;ANKGWALDNMVLCNEVTK;AVECIISVPK;CVDYFQR;DALDCMFDAR;GVSWTTIRYMIGEIQYGGR;IMDCVLLLFQRKVSAVK;INNELLEFQNR;LNIPNLGIDDK;LYTKQKYDPPLAR;MLPTPAKFHYVFNLR;NVSENKEIVKLVSVLSTIINSTK;QLPKEAK;QTNDLHNELR;RLAKIIDIFTTLK;SFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLK;SVAMMVPDR;TWREMDIR;VKSKIPAAIEQLIVPHLAK;VTDDYDKR;YLYTLEK;YPLLIDPQTQGKIWIK 22 6.4 0.97853 -9.0859 0 0 0 0 3.97223 8.39631 9.56769 12.0625 12.128 10.8377 10.816 11.0466 Q8TE76 MORC4_HUMAN MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) MORC4 ZCW4 ZCWCC2 Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP hydrolysis activity [GO:0016887]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] TVFIDVEEVK;VEAPVAYPEGENSHDK 2 2.8 0.42368 0.19725 5.54723 0 0 0 0 3.88606 0 0 0 0 0 0 Q8TE77 SSH3_HUMAN Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) SSH3 SSH3L Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] "actin binding [GO:0003779]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" EIDNFYPER;GPQPALK 2 2.4 0.96575 -1.1232 0 0 10.9217 7.00405 0 7.11145 10.7564 11.2603 0 0 0 0 Q8TE82 S3TC1_HUMAN SH3 domain and tetratricopeptide repeat-containing protein 1 SH3TC1 Homo sapiens (Human) AVSFYRDRALPLAVTTGNR;LAALQHR;LNERVAYHR;LNERVAYHRLAALQHR;SFFSEGCFSEEDARQLLR;TVVMRPSVSWEKAGPEEAK 6 5.4 0.97659 -2.1776 0 0 8.0376 0 0 0 12.2921 9.90994 0 0 9.29375 0 Q8TE96 DQX1_HUMAN ATP-dependent RNA helicase DQX1 (EC 3.6.4.12) (DEAQ box polypeptide 1) DQX1 Homo sapiens (Human) spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518] CQAEARRLR;GTGAWGVLVLDEAQER 2 3.5 0.79796 0.014797 0 0 0 0 0 0 0 3.39259 0 9.24634 0 0 Q8TE99 PXYP1_HUMAN 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124) PXYLP1 ACPL2 HEL124 XYLP UNQ370/PRO706 Homo sapiens (Human) chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] phosphatase activity [GO:0016791] IVDVPTK;VIKTHQIEDER 2 3.8 0.95373 -0.92436 0 0 0 0 7.77873 0 0 0 0 0 0 0 Q8TEA1 NSUN6_HUMAN tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6) NSUN6 NOPD1 Homo sapiens (Human) RNA methylation [GO:0001510]; tRNA C5-cytosine methylation [GO:0002946]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; cytosol [GO:0005829] tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049] FDPSAVPLPDTDMDSLREAR;MSIFPKISLRPEVENYLK 2 8.1 0.9277 -0.45848 0 0 0 0 0 0 0 0 0 5.9176 0 5.88051 Q8TEA7 TBCK_HUMAN TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1) TBCK FERRY1 TBCKL HSPC302 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; regulation of TOR signaling [GO:0032006] cytoplasm [GO:0005737]; early endosome [GO:0005769]; midbody [GO:0030496]; mitotic spindle [GO:0072686] ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; protein kinase activity [GO:0004672] KPLPSGPK;LVVVAEHCERSLEDLLRER;SSLLDDTTVTLSLCQLRNRLK 3 5.4 0.90784 -0.30307 0 9.4417 6.7952 0 0 0 0 0 0 0 0 8.03727 Q8TEB1 DCA11_HUMAN DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 GL014 PRO2389 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] IVSSSWDGNLRLWQYR;MLHQRER;RFSSREGMEASR 3 6.4 0.95493 -0.78983 0 0 0 7.06566 0 7.41523 0 0 8.69631 11.2974 0 0 Q8TEB7 RN128_HUMAN E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128) RNF128 Homo sapiens (Human) negative regulation of cytokine production [GO:0001818]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; protein localization to lysosome [GO:0061462]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GNCTFSEKIQTAGRR 1 3.7 0.85097 -0.07926 0 0 0 0 0 0 0 0 0 7.4363 0 0 Q8TEC5 SH3R2_HUMAN E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) SH3RF2 POSH3 POSHER PPP1R39 RNF158 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; ubiquitin protein ligase activity [GO:0061630] IHMDGVPRAKALCNYR;LVPNVRIHMDGVPRAK;QLPQPPPLCRALYNFDLRGK;VFKAHKELR;VLGKCQDGWLR;VPGQFSITTALNTLNR 6 10.7 0.97495 -3.708 0 12.707 9.41701 0 0 0 10.9501 0 0 4.71633 3.87637 0 Q8TED0 UTP15_HUMAN U3 small nucleolar RNA-associated protein 15 homolog UTP15 Homo sapiens (Human) positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] APLRQFEGHTK 1 2.1 0.92052 -0.44378 0 0 0 0 0 0 7.83023 0 0 0 0 0 Q8TED1 GPX8_HUMAN Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9) GPX8 UNQ847/PRO1785 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599] endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601] ILGSEGEPAFR;VFAVLLSIVLCTVTLFLLQLK 2 15.3 0.90945 -0.31277 0 3.45154 0 0 0 0 9.06832 0 0 0 0 0 Q8TED4 G6PT3_HUMAN Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2) SLC37A2 Homo sapiens (Human) glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062] glucose 6-phosphate:phosphate antiporter activity [GO:0061513] VSLSRGSGYK 1 2 0.88717 -0.18273 0 0 0 0 9.88716 0 0 0 0 0 0 0 Q8TED9 AF1L1_HUMAN Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) AFAP1L1 Homo sapiens (Human) anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytosol [GO:0005829]; podosome [GO:0002102]; stress fiber [GO:0001725] MQDEEPERPTGAQVKRHASSCSEK 1 3.1 0.61967 0.1736 0 9.89939 0 0 0 0 0 0 0 0 0 0 Q8TEE9 SAP25_HUMAN Histone deacetylase complex subunit SAP25 (25 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP25) SAP25 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] TPLAPWDPKYEAK 1 6.5 0.95302 -0.67833 0 0 0 0 0 9.75447 0 0 0 0 0 0 Q8TEJ3 SH3R3_HUMAN E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) SH3RF3 POSH2 SH3MD4 Homo sapiens (Human) positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] RVDENWAEGMLGDK;VLPCQHTFCR 2 2.7 0.29904 0.25245 4.30071 0 0 0 0 0 0 0 0 0 0 5.68429 Q8TEK3 DOT1L_HUMAN "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)" DOT1L KIAA1814 KMT4 Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; gene expression [GO:0010467]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; subtelomeric heterochromatin formation [GO:0031509]; telomere organization [GO:0032200] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K79 methyltransferase activity [GO:0031151]; histone H3K79 trimethyltransferase activity [GO:0140956]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] GTTQPMK;VAGPADAPMDSGAEEEK 2 1.6 0.91879 -0.43576 0 0 0 0 0 0 0 0 0 8.92011 0 6.03754 Q8TEM1 PO210_HUMAN Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) NUP210 KIAA0906 PSEC0245 Homo sapiens (Human) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] DGAASLSYRVLDGPEK;DLAVPAALTPR;EVVVSVPQR;VFGAPEVLENLEVK;VGQALELPLR;VLDGPEKVPVVHVDEK;VLLPFTR;VVIISQDLVQVEVLLLRAVR 8 5.1 0.98065 -1.7948 7.28337 11.1782 0 0 0 0 9.02661 11.7889 0 8.44319 8.89175 0 Q8TEP8 CE192_HUMAN Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2) CEP192 KIAA1569 PP8407 Homo sapiens (Human) centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]; response to bacterium [GO:0009617] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099] phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901] ALLHKPEMIK;ITSLCLLK;KATETTSLSSKPEYVKPDFR;TINSSNSVTNR;VLLDPKVLRIFPDK;VPFQNRGK;WHLSSLAPPYVK 7 3.3 0.98121 -1.7041 6.64847 13.0032 8.42471 8.04128 10.8553 6.05209 0 6.29357 7.88753 3.35021 0 0 Q8TEQ6 GEMI5_HUMAN Gem-associated protein 5 (Gemin5) GEMIN5 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; protein-containing complex assembly [GO:0065003]; regulation of translation [GO:0006417]; spliceosomal snRNP assembly [GO:0000387]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Gemin2 complex [GO:0034718]; SMN-Sm protein complex [GO:0034719] mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; snRNA binding [GO:0017069]; U1 snRNA binding [GO:0030619]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] DLYLSWGTVLERDGHYAVAAK;GRGVMILKLPFLK;KPTLRTPVK;LESIDGNEEESMK 4 3.7 0.97197 -1.3581 0 0 0 7.85387 0 9.7388 0 4.78743 0 9.73816 0 0 Q8TEQ8 PIGO_HUMAN GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O) PIGO UNQ632/PRO1249 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] mannose-ethanolamine phosphotransferase activity [GO:0051377] RPLATLFPIPGPVLLLLLFR;VRPEEEEEPLMEMR 2 3.1 0.50588 0.1882 0 0 0 0 0 9.65044 7.4412 0 0 0 5.88208 0 Q8TER0 SNED1_HUMAN "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) cell-matrix adhesion [GO:0007160] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] NGGTCKEAGGEYHCSCPYR;VSRPCTR 2 1.8 0.94012 -0.58087 0 3.9331 0 0 0 8.77288 0 0 0 0 0 0 Q8TER5 ARH40_HUMAN Rho guanine nucleotide exchange factor 40 (Protein SOLO) ARHGEF40 SOLO Homo sapiens (Human) axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ALGAAVQLLREQEARGR;GAGGKGR;LSNLHVQQQEQR;LSNLHVQQQEQRQCLRR;LSTCLLSAPSGIQR;RIQQHVGEEASPRGYR;SFHRTHFLR 7 5.3 0.97265 -2.7734 7.31805 0 0 10.4009 0 0 12.0773 0 12.1367 10.6439 11.4636 0 Q8TES7 FBF1_HUMAN Fas-binding factor 1 (FBF-1) (Protein albatross) FBF1 ALB KIAA1863 Homo sapiens (Human) apical junction assembly [GO:0043297]; cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162] anchoring junction [GO:0070161]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; spindle pole [GO:0000922] EDWLSHALSRKK;FSSEDLEDPLR;KVTAQQMAMER;LGQQQRDMEEER;LLEQERWR 5 4.8 0.97262 -2.7258 10.6573 7.12846 0 0 0 9.31393 0 0 0 10.2753 0 0 Q8TET4 GANC_HUMAN Neutral alpha-glucosidase C (EC 3.2.1.20) GANC Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]" IAFYRRQK;ILVLGFR;LIREAIRER 3 2.6 0.97218 -2.7901 0 0 0 0 0 0 7.39412 0 0 0 0 0 Q8TEU7 RPGF6_HUMAN Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) RAPGEF6 PDZGEF2 Homo sapiens (Human) microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087] apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267] ELDRSGTRK;HSIQHVPGDIEQTSQEK;IVTQPQRHNLQPFHPK;NIEPTEYIDDLFK;QYLSSLDVETDEEK;TGNTHLK;TNIFVFKELLFRTEQEK 7 5.8 0.96487 -1.2255 8.9359 0 6.6768 10.6997 0 10.098 0 10.4815 0 9.74505 9.61482 0 Q8TEU8 WFKN2_HUMAN "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related protein)" WFIKKN2 GASP1 WFIKKNRP UNQ9235/PRO31996 Homo sapiens (Human) muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431] CCPNVCGTKSCVAAR;CYMDAEACSK;ECETDQECETYEK 3 6.6 0.97685 -2.1738 0 0 0 0 0 5.39678 0 0 0 11.4482 0 0 Q8TEV9 SMCR8_HUMAN Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) SMCR8 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of exocytosis [GO:0045920]; negative regulation of gene expression [GO:0010629]; negative regulation of immune response [GO:0050777]; negative regulation of macroautophagy [GO:0016242]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432] Atg1/ULK1 kinase complex [GO:1990316]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] AGQNALK 1 0.7 0.64599 0.17143 10.488 0 0 0 0 0 0 0 0 8.18378 8.78591 0 Q8TEW0 PARD3_HUMAN Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of myelination [GO:0031643]; protein localization [GO:0008104]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ELKAEDEDIVLTPDGTR;ISKCNELK;NPTRWSTTAGFLK;QEDAFHPRELK;SIINGGAASK;SPGSPPGPELPIETALDDRER 6 6.2 0.97629 -4.4777 0 13.0794 0 8.90388 0 10.7619 0 0 0 10.0849 10.0764 0 Q8TEW6 DOK4_HUMAN Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5) DOK4 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; cytosol [GO:0005829] LEKYPDEKSVCLR;VLLEMEK 2 6.1 0.98156 -1.7672 0 0 0 0 0 0 0 3.2326 0 0 0 10.4737 Q8TEW8 PAR3L_HUMAN Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) PARD3B ALS2CR19 PAR3B PAR3L Homo sapiens (Human) cell adhesion [GO:0007155]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; protein localization [GO:0008104] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; endomembrane system [GO:0012505]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] GFGAMLR;GPDGNAHNLRFEGMER;LGGKPSSPSLSPLMGFGSNK;MKEERER;QYASLPRGGPADPVDYLPAAPR;VNHFREPCTSANVFRSPSPPR 6 7.7 0.97507 -1.4555 8.83864 0 6.03177 7.40071 0 0 0 8.47626 9.58502 0 12.0885 0 Q8TEX9 IPO4_HUMAN Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) IPO4 IMP4B RANBP4 Homo sapiens (Human) protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] DNICGALAR;EVMPLLLAYLK;LAELCGVLK;NVALGNAIR;TKQGCTVAEK 5 4.4 0.97314 -2.5349 0 0 13.3421 9.04887 0 0 10.7024 11.9492 0 0 0 11.9751 Q8TEY5 CR3L4_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] CREB3L4 AIBZIP CREB4 JAL Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DVTENLETQVVESR 1 3.5 0.88117 -0.15297 0 0 0 0 0 0 0 0 9.14006 0 0 0 Q8TEY7 UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) USP33 KIAA1097 VDU1 Homo sapiens (Human) axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; centrosome duplication [GO:0051298]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; positive regulation of protein binding [GO:0032092]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; VCB complex [GO:0030891] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] IPNKMSAFR;KSSEEAQKER;LMTELWHKSRPGSVVPTTLFQGIKTVNPTFR;LSASPPK;SLGTCQDCK;SSEEAQK;SYLKLMTELWHK;VLPHFESLGK 8 8.5 0.97361 -2.9811 7.66711 0 9.34556 9.90032 8.83983 8.84351 0 0 0 12.9143 10.1952 0 Q8TF01 PNISR_HUMAN "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] RNA binding [GO:0003723] GSESSDTDDEELRHRIR;QMEEEKQQTERVTK 2 3.9 0.74449 0.098974 6.85312 0 0 0 0 6.96486 0 0 0 0 0 0 Q8TF05 PP4R1_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 1 PPP4R1 MEG1 PP4R1 Homo sapiens (Human) protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; protein phosphatase 4 complex [GO:0030289] protein phosphatase regulator activity [GO:0019888] DVYDYLRPIALNLCADK;FCEMCCDCRMFHVR;VLLAKTLRQTLLEK 3 4.7 0.64205 0.17187 2.80304 0 3.93045 0 7.49305 0 7.68004 0 0 0 0 0 Q8TF08 CX7B2_HUMAN "Cytochrome c oxidase subunit 7B2, mitochondrial (Cytochrome c oxidase polypeptide VIIb2)" COX7B2 Homo sapiens (Human) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; spermatogenesis [GO:0007283]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] MMFPLAR;VTPKEWK 2 17.3 0.98075 -1.6042 0 0 0 0 0 7.90551 0 0 0 0 0 0 Q8TF17 S3TC2_HUMAN SH3 domain and tetratricopeptide repeat-containing protein 2 SH3TC2 KIAA1985 PP12494 Homo sapiens (Human) peripheral nervous system myelin maintenance [GO:0032287]; regulation of ERBB signaling pathway [GO:1901184]; regulation of intracellular protein transport [GO:0033157] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] EGECLTLCK;LVSIQSQRAQFLITFK;YWLNCILVEDTEIQVSVDDK 3 3.5 0.95267 -0.75084 7.27529 0 0 0 0 0 0 0 0 9.89828 0 0 Q8TF20 ZN721_HUMAN Zinc finger protein 721 ZNF721 KIAA1982 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFRQSAILYVHR;GIHAGEKPYTCEER;GRSFGWSTNLNEYK;RIHTGEKPYTCEECGK 4 9.2 0.97379 -1.4047 0 0 0 0 0 0 0 6.5314 0 0 8.53006 10.0612 Q8TF21 ANR24_HUMAN Ankyrin repeat domain-containing protein 24 ANKRD24 KIAA1981 Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605] plasma membrane [GO:0005886]; stereocilium [GO:0032420] actin binding [GO:0003779] GLRAELAQREEAR;TSAEVFQVQREALFMKSER;VQILENFEK 3 3.6 0.93709 -0.55669 9.29239 0 0 0 0 0 0 0 0 0 0 6.65249 Q8TF30 WHAMM_HUMAN "WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)" WHAMM KIAA1971 WHDC1 Homo sapiens (Human) actin filament organization [GO:0007015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; microtubule [GO:0005874] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] DKIKEEEQK;EVATLCK;LQQAEESIR 3 3.1 0.97865 -1.9049 0 0 0 0 10.6546 0 0 0 0 11.0503 0 0 Q8TF32 ZN431_HUMAN Zinc finger protein 431 ZNF431 KIAA1969 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ENSYQCEECGK;QNNSYWRETLQMSRMWESL 2 5.2 0.49614 0.18922 0 0 0 5.4485 0 0 0 0 0 0 0 0 Q8TF39 ZN483_HUMAN Zinc finger protein 483 (Zinc finger protein with KRAB and SCAN domains 16) ZNF483 KIAA1962 ZKSCAN16 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CLRDDDHGLMEESQQYCGSSEEDHGNQGNSK;DVAVNFSR;IHTGEKPYECNYCGATFSR;LEPFQKELYKEVLLENLR;YNESKKPFSFHSDLVLNR 5 12.6 0.97767 -2.1342 10.5147 0 11.0358 0 0 0 6.64357 9.0885 10.6356 10.0753 0 0 Q8TF40 FNIP1_HUMAN Folliculin-interacting protein 1 FNIP1 KIAA1961 Homo sapiens (Human) B cell apoptotic process [GO:0001783]; B cell differentiation [GO:0030183]; cellular response to starvation [GO:0009267]; immature B cell differentiation [GO:0002327]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lysosome organization [GO:1905672]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] ATPase inhibitor activity [GO:0042030]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087] DEDENNK;LIVYQDCERR;LIVYQDCERRGR;LLDSDSHTGK;NVLFDSSVK 5 3.3 0.97698 -2.1734 0 0 6.8116 0 0 0 0 0 0 11.8344 0 0 Q8TF44 C2C4C_HUMAN C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) C2CD4C FAM148C KIAA1957 NLF3 Homo sapiens (Human) cytosol [GO:0005829] DTLLGEKELPLTSLLPFL;GVGSEAGDKASK;LALRIKVVNK;SINCCVGLCLVPGK 4 12.8 0.87372 -0.11669 0 0 0 7.46271 0 9.26962 10.2365 0 0 0 0 0 Q8TF45 ZN418_HUMAN Zinc finger protein 418 ZNF418 KIAA1956 Homo sapiens (Human) microautophagy [GO:0016237]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EECYCWECGK;HSSTKHVFVQQQRLPSR;SFSRKGHLR;SHLIEHQRVHTGERPYECNECGK;SHTGERPYECR 5 10.4 0.96109 -1.0628 0 0 0 0 5.51188 0 7.85798 0 0 0 10.1117 0 Q8TF46 DI3L1_HUMAN DIS3-like exonuclease 1 (EC 3.1.13.1) DIS3L DIS3L1 KIAA1955 Homo sapiens (Human) mRNA catabolic process [GO:0006402]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075] centrosome [GO:0005813]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3'-5'-RNA exonuclease activity [GO:0000175]; enzyme binding [GO:0019899]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723] ASYEIKKVWYGR;IDSWESTSVYPNGHFVRVLGR;LEELVWAIGK;VSPEEEQKR 4 4.9 0.97386 -1.3957 9.97111 0 10.8091 0 0 0 0 0 0 0 0 0 Q8TF50 ZN526_HUMAN Zinc finger protein 526 ZNF526 KIAA1951 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SFSSANRLQAHGR;SPYYCGTCGR 2 3.4 0.91654 -0.41638 0 6.49819 0 0 0 0 0 0 0 0 0 10.218 Q8TF61 FBX41_HUMAN F-box only protein 41 FBXO41 FBX41 KIAA1940 Homo sapiens (Human) cytosol [GO:0005829] EELEERASELSR;EKEELEER;ESKEEYAR;GCLEAGLESLLKAAGGNLLILRISHCPNILTDR;ISHCPNILTDR;KQQEVVQIDQFLKETAAR 6 8.3 0.97479 -3.842 11.3875 0 8.72185 0 0 0 0 0 0 0 11.882 0 Q8TF62 AT8B4_HUMAN Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) ATP8B4 KIAA1939 Homo sapiens (Human) Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332] Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] RSGYAFAHQEGYGELITSGK 1 1.7 0.87251 -0.11254 0 0 9.58643 0 0 0 0 0 0 0 0 0 Q8TF65 GIPC2_HUMAN PDZ domain-containing protein GIPC2 GIPC2 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802] KEELFTMKLIEPK;SSGEKIGCGRATLR 2 8.6 0.96546 -1.1334 0 0 0 8.63604 0 0 0 11.3312 0 0 0 0 Q8TF68 ZN384_HUMAN Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) ZNF384 CAGH1 CIZ NMP4 TNRC1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DKPFKCHNCHR 1 1.9 0.92099 -0.44634 0 0 0 0 0 0 0 8.98316 0 0 0 0 Q8TF71 MOT10_HUMAN Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) SLC16A10 MCT10 TAT1 Homo sapiens (Human) amino acid transport [GO:0006865]; aromatic amino acid transport [GO:0015801]; thyroid hormone generation [GO:0006590]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460] basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349] EKMEKMLENQNSLLSSSSGMFK 1 4.3 0.86494 -0.087715 0 0 0 0 8.51068 0 0 0 0 0 0 0 Q8TF72 SHRM3_HUMAN Protein Shroom3 (Shroom-related protein) (hShrmL) SHROOM3 KIAA1481 SHRML MSTP013 Homo sapiens (Human) actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; cell morphogenesis [GO:0000902]; cellular pigment accumulation [GO:0043482]; pattern specification process [GO:0007389]; regulation of cell shape [GO:0008360] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; microtubule [GO:0005874] actin filament binding [GO:0051015] AAPDLGSHLDR;FPESSVADRR;LSKVTIARER 3 1.6 0.91711 -0.34353 0 12.8205 0 0 0 0 0 0 10.3399 0 6.55938 0 Q8TF74 WIPF2_HUMAN WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) WIPF2 WICH WIRE PP10631 Homo sapiens (Human) cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779] LSRDEQRGR;VTNINDR 2 3.6 0.94114 -0.6015 0 0 0 0 0 0 0 11.5504 0 0 0 0 Q8TF76 HASP_HUMAN Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) HASPIN GSG2 Homo sapiens (Human) "intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]" centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] RPGREAAQWFPPQDR;VPKDRPSLTVTPKR 2 3.6 0.89883 -0.2574 0 0 0 0 0 0 0 8.84696 0 7.33548 0 0 Q8WTQ4 CP078_HUMAN Uncharacterized protein C16orf78 C16orf78 Homo sapiens (Human) nucleus [GO:0005634] MSDLTCVLEWLERRQGK 1 6.4 0.85382 -0.08043 12.2957 0 0 0 0 0 0 0 0 0 0 0 Q8WTR2 DUS19_HUMAN Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1) DUSP19 DUSP17 LMWDSP3 SKRP1 Homo sapiens (Human) negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of JNK cascade [GO:0046328] cytoplasm [GO:0005737] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; JUN kinase phosphatase activity [GO:0008579]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP-kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase activator activity [GO:0030295]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" AAAIVIGFLMNSEQTSFTSAFSLVK;NKVTHILNVAYGVENAFLSDFTYK 2 22.6 0.97762 -1.5163 0 0 0 9.44619 0 0 0 0 10.5986 0 0 0 Q8WTR7 ZN473_HUMAN Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100) ZNF473 KIAA1141 ZFP100 Homo sapiens (Human) mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; regulation of transcription by RNA polymerase II [GO:0006357] Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FYVCNEYGTTFSQSTYLWHQK;HLIQHQKTHAAK;LQSFHTKEHPFK;LTQHWITHTR 4 6.3 0.97298 -2.5193 0 0 0 0 0 0 11.8366 16.2943 0 0 10.8116 0 Q8WTR8 NET5_HUMAN Netrin-5 (Netrin-1-like protein) NTN5 Homo sapiens (Human) neurogenesis [GO:0022008] extracellular region [GO:0005576] LILDRHGLALPWRPRWARPLK 1 4.3 0.53035 0.18665 0 0 5.68294 0 0 0 0 0 0 0 0 0 Q8WTS6 SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) SETD7 KIAA1717 KMT7 SET7 SET9 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; heterochromatin organization [GO:0070828]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of DNA-templated transcription [GO:0045893]; response to ethanol [GO:0045471] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone methyltransferase activity [GO:0042054]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279] IAYVYPDER 1 2.5 0.91733 -0.42502 0 0 0 0 0 0 0 11.3308 0 0 0 0 Q8WTT2 NOC3L_HUMAN Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) NOC3L AD24 C10orf117 FAD24 Homo sapiens (Human) DNA replication initiation [GO:0006270]; fat cell differentiation [GO:0045444] mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] EAEASESTEK;LISEMCCEAVK;SLSRMQRK 3 3.6 0.97453 -2.4082 0 0 0 0 0 0 0 0 0 8.81919 0 0 Q8WTU0 DDI1_HUMAN Protein DDI1 homolog 1 (EC 3.4.23.-) DDI1 Homo sapiens (Human) cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647] aspartic-type endopeptidase activity [GO:0004190] DLSEVTFSLQVSPDFELR 1 4.5 0.78303 0.022204 0 0 0 0 0 0 0 0 0 0 9.32775 0 Q8WTU2 SRB4D_HUMAN Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB) SSC4D SRCRB4D Homo sapiens (Human) extracellular region [GO:0005576]; membrane [GO:0016020] EAEMLIGPQLDEKR;LVGGPSRCR 2 8.4 0.96673 -1.3008 0 8.3658 0 0 0 10.5364 0 0 0 0 0 0 Q8WTV0 SCRB1_HUMAN "Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)" SCARB1 CD36L1 CLA1 Homo sapiens (Human) adhesion of symbiont to host [GO:0044406]; blood vessel endothelial cell migration [GO:0043534]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; detection of lipopolysaccharide [GO:0032497]; endothelial cell proliferation [GO:0001935]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal lipid absorption [GO:0098856]; lipopolysaccharide transport [GO:0015920]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of triglyceride biosynthetic process [GO:0010867]; recognition of apoptotic cell [GO:0043654]; regulation of phagocytosis [GO:0050764]; regulation of phosphatidylcholine catabolic process [GO:0010899]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transmembrane transport [GO:0035461]; wound healing [GO:0042060] caveola [GO:0005901]; cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] 1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor activity [GO:0070506]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; scavenger receptor activity [GO:0005044]; virus receptor activity [GO:0001618] VMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQR;YFPGMFPFK 2 7.8 0.95497 -0.95007 0 0 0 0 10.6156 11.2559 0 0 0 0 0 0 Q8WTV1 THAP3_HUMAN THAP domain-containing protein 3 THAP3 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LGPEQQS 1 2.9 0.91166 -0.32753 0 0 0 0 0 0 0 5.86881 0 0 0 0 Q8WTW4 NPRL2_HUMAN GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; negative regulation of kinase activity [GO:0033673]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508] GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774] GTPase activator activity [GO:0005096] ELFDTVQVYIITKPELQNKLITVTAMEK;LVPIMTILLEELNASGR;SLQEACLSYVTKQGHK;VQDLVDDK 4 18.2 0.97466 -1.3856 11.5329 0 8.31529 0 8.31728 8.62234 0 0 0 0 0 0 Q8WTX9 ZDHC1_HUMAN Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 1) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) ZDHHC1 C16orf1 ZNF377 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794] DNA binding [GO:0003677]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] GACIKCERLRPR;GRGACIK;HCSACNKCVCGFDHHCK;QSPWTRFQWR 4 8.5 0.97467 -3.4904 0 0 0 0 0 0 0 10.9407 0 0 10.3529 6.57525 Q8WU03 GLYL2_HUMAN Glycine N-acyltransferase-like protein 2 (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase-like protein 2) GLYATL2 Homo sapiens (Human) long-chain fatty acid catabolic process [GO:0042758]; medium-chain fatty acid catabolic process [GO:0051793]; monounsaturated fatty acid catabolic process [GO:1903965] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] glycine N-acyltransferase activity [GO:0047961] ICPCGWHQWKCTPKK 1 5.1 0.85119 -0.07926 0 0 0 0 0 6.63494 0 0 0 0 0 0 Q8WU08 ST32A_HUMAN Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1) STK32A YANK1 Homo sapiens (Human) intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KMYAMKYMNK 1 2.5 0.86599 -0.091931 0 6.26523 0 0 0 0 0 0 0 0 0 0 Q8WU10 PYRD1_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) PYROXD1 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599] nucleus [GO:0005634]; sarcomere [GO:0030017] oxidoreductase activity [GO:0016491] AIGNTFFDAGAAEFLTSK;IYLQDEFR 2 5.2 0.94109 -0.60939 0 7.02303 0 0 0 0 0 0 0 0 0 0 Q8WU17 RN139_HUMAN E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) RNF139 TRC8 Homo sapiens (Human) endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613] Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AFMMCLHAYFNIYLQAK;INSLPEIK 2 3.8 0.93326 -0.50713 0 0 12.3295 0 0 0 0 0 8.0445 5.80911 0 0 Q8WU20 FRS2_HUMAN Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) FRS2 Homo sapiens (Human) "anterior/posterior axis specification, embryo [GO:0008595]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation with mouth forming second [GO:0001702]; lens fiber cell development [GO:0070307]; lens placode formation involved in camera-type eye formation [GO:0046619]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ventricular septum development [GO:0003281]" adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatase activator activity [GO:0019211]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LSRDEDDNLGPK;RTALLNYENLPSLPPVWEAR 2 6.3 0.88567 -0.19684 0 0 0 0 0 0 0 0 0 7.20242 0 0 Q8WU49 CG033_HUMAN Uncharacterized protein C7orf33 C7orf33 Homo sapiens (Human) KLQNSVEATR 1 5.6 0.90723 -0.30348 0 0 0 0 8.49937 0 0 0 0 0 0 0 Q8WU58 F222B_HUMAN Protein FAM222B FAM222B C17orf63 Homo sapiens (Human) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] AGLLAIVKVPAKSILK;VANNPLTIK 2 4.4 0.91551 -0.33929 0 0 12.6405 0 0 3.8024 4.02892 0 0 0 0 0 Q8WU67 ABHD3_HUMAN Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3) ABHD3 Homo sapiens (Human) medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470] plasma membrane [GO:0005886] acetylesterase activity [GO:0008126]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; monoacylglycerol lipase activity [GO:0047372]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] EQARSHISFI 1 7.4 0.98149 -1.5899 0 0 0 0 0 0 0 10.5213 0 0 0 0 Q8WU76 SCFD2_HUMAN Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) SCFD2 STXBP1L1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] DLVASLKPGTQVIVLSTR 1 2.6 0.64835 0.17038 9.01475 0 0 0 0 0 9.76698 0 0 0 0 0 Q8WU79 SMAP2_HUMAN Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) SMAP2 SMAP1L Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] NLGVHISRVK 1 2.3 0.9778 -1.5014 0 0 0 0 0 0 0 0 0 10.2345 0 0 Q8WU90 ZC3HF_HUMAN Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; cytoplasmic translation [GO:0002181]; positive regulation of GTPase activity [GO:0043547] cytosol [GO:0005829]; nucleus [GO:0005634] cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] AVTHQVKFGQQNPR;FSHDLTLERKCEK;QEKIDKLEQDMER;QVAQSEAEK;SVYIDARDEELEK 5 14.6 0.9751 -4.1722 0 0 0 10.9166 0 9.90161 9.19017 0 9.79299 0 0 0 Q8WUA2 PPIL4_HUMAN Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) PPIL4 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] EDEDYMPIK;IGADEEIDDFKGR;KTHHCSEEKEDEDYMPIK 3 6.3 0.84731 -0.064844 0 5.75825 0 9.04592 0 3.57471 0 0 0 0 0 0 Q8WUA4 TF3C2_HUMAN General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) GTF3C2 KIAA0011 Homo sapiens (Human) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797] nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] RNA polymerase III general transcription initiation factor activity [GO:0000995] AYFTAPR;LEQPDLSSEMSK;LSDGSLK 3 2.9 0.98022 -1.5567 0 0 0 0 0 0 7.40837 0 0 0 0 0 Q8WUA7 TB22A_HUMAN TBC1 domain family member 22A TBC1D22A C22orf4 Homo sapiens (Human) Golgi apparatus [GO:0005794] 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803] FKQLLAGPNTDLEELR;HLDQHEVRYLQFAFR;ILFIWAIR;QFWKRSNSK 4 9.3 0.81061 -0.014547 0 0 0 0 0 0 0 5.99661 0 0 0 0 Q8WUA7 TB22A_HUMAN TBC1 domain family member 22A TBC1D22A C22orf4 Homo sapiens (Human) Golgi apparatus [GO:0005794] 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803] HLDQHEVRYLQFAFR;ILFIWAIR;LVKSVSESHTSCPAEELR;QFWKRSNSK 4 11.4 0.97336 -2.9747 0 6.46431 0 0 9.45418 0 0 0 0 0 6.54223 8.82063 Q8WUB8 PHF10_HUMAN PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) PHF10 BAF45A Homo sapiens (Human) chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] VLPTERTK;WICDCCQR 2 3.2 0.97455 -1.3928 0 0 0 0 0 0 0 0 0 4.96 0 0 Q8WUD4 CCD12_HUMAN Coiled-coil domain-containing protein 12 CCDC12 Homo sapiens (Human) nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684] RVPQAKPVAVEEKVK 1 9 0.96153 -1.0714 0 0 0 0 0 0 0 0 0 0 8.65935 0 Q8WUF5 IASPP_HUMAN RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) PPP1R13L IASPP NKIP1 PPP1R13BL RAI Homo sapiens (Human) apoptotic process [GO:0006915]; cardiac muscle contraction [GO:0060048]; cardiac right ventricle morphogenesis [GO:0003215]; embryonic camera-type eye development [GO:0031076]; hair cycle [GO:0042633]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; ventricular cardiac muscle tissue development [GO:0003229] cell junction [GO:0030054]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] GAPRQRPIPLSMIFK;KAATDGADTPFGR 2 3.4 0.97765 -1.5213 0 0 0 0 0 0 9.80982 0 0 11.2718 0 0 Q8WUF8 ARB2A_HUMAN Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) ARB2A C5orf21 FAM172A Homo sapiens (Human) "mRNA processing [GO:0006397]; neural crest cell development [GO:0014032]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]" endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] HELTSWKSFPSIFK;TIREWMR 2 5 0.97329 -2.885 0 0 0 0 0 0 10.8363 0 11.0694 0 0 0 Q8WUG5 S22AH_HUMAN Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR) SLC22A17 BOCT BOIT Homo sapiens (Human) intracellular iron ion homeostasis [GO:0006879]; siderophore transport [GO:0015891] organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] transmembrane signaling receptor activity [GO:0004888]; transmembrane transporter activity [GO:0022857] LLPEVLRDGELCRRPSLLR 1 2.9 0.8494 -0.076374 0 10.0768 0 0 0 0 0 0 0 0 0 0 Q8WUH1 CHUR_HUMAN Protein Churchill CHURC1 C14orf52 CHCH My015 Homo sapiens (Human) fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of DNA-templated transcription [GO:0045893] zinc ion binding [GO:0008270] EEDGEEIVTYDPDLCKNCHHVIAR;RDFMLITNK 2 29.2 0.95494 -0.86644 0 0 0 0 6.32582 0 0 0 0 0 0 0 Q8WUH6 TM263_HUMAN Transmembrane protein 263 TMEM263 C12orf23 Homo sapiens (Human) membrane [GO:0016020] GAVGATIGGVAWIGGK 1 13.8 0.93674 -0.55456 10.3414 0 0 0 0 0 0 0 0 0 0 0 Q8WUI4 HDAC7_HUMAN Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) HDAC7 HDAC7A Homo sapiens (Human) cell-cell junction assembly [GO:0007043]; chromatin organization [GO:0006325]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of mRNA processing [GO:0050684]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714]; tubulin deacetylase activity [GO:0042903]" VHSKYWGCMQR 1 1.2 0.92202 -0.44542 0 0 0 0 0 0 0 0 0 0 6.66945 0 Q8WUJ0 STYX_HUMAN Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) STYX Homo sapiens (Human) negative regulation of protein binding [GO:0032091]; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] F-box domain binding [GO:1990444]; pseudophosphatase activity [GO:0001691] YLVLDIADNPVENIIR 1 7.2 0.78248 0.026152 0 0 0 0 0 0 0 0 0 4.57755 0 0 Q8WUJ3 CEMIP_HUMAN Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) (Hyaluronan binding protein involved in hyaluronan depolymerization) CEMIP HYBID KIAA1199 Homo sapiens (Human) hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605] clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415] IFQVVPIPVVKKK;SGTLLPSDRDSK;VEQSYPGR 3 2.4 0.97838 -1.9278 0 0 0 6.39796 0 0 0 0 9.8454 0 0 0 Q8WUJ3 CEMIP_HUMAN Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) (Hyaluronan binding protein involved in hyaluronan depolymerization) CEMIP HYBID KIAA1199 Homo sapiens (Human) hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605] clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415] AASGPSG;SGTLLPSDRDSK 2 1.9 0.7114 0.15645 0 0 0 0 0 7.00383 0 0 0 6.89591 0 0 Q8WUK0 PTPM1_HUMAN "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16, EC 3.1.3.48)" PTPMT1 MOSP PLIP PNAS-129 Homo sapiens (Human) cardiolipin biosynthetic process [GO:0032049]; regulation of intrinsic apoptotic signaling pathway [GO:2001242] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylglycerophosphatase activity [GO:0008962]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" VLFYPTLLYTLFR 1 6.5 0.71584 0.13753 0 0 0 0 10.1392 0 0 0 0 0 0 0 Q8WUM0 NU133_HUMAN Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) NUP133 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; paraxial mesoderm development [GO:0048339]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]; somite development [GO:0061053]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] ALDLLEYIDEEEDININDLK;NSLYRREESLEK 2 2.8 0.9648 -1.1676 0 9.10389 0 0 0 0 0 0 0 8.90029 0 0 Q8WUM4 PDC6I_HUMAN Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702] actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020] calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871] AAEELSK;STPVNVPISQK;YDEYVNVKDFSDKINR 3 3.9 0.95565 -0.94051 0 9.30866 0 0 9.26184 0 0 0 0 0 0 0 Q8WUM4 PDC6I_HUMAN Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702] actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020] calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871] AAEELSK;QCQYKDTLPKVSYCFYK;YLDFFVYK 3 11.8 0.9804 -1.5955 0 0 0 0 9.08574 0 0 0 0 0 8.75275 0 Q8WUM9 S20A1_HUMAN Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) SLC20A1 GLVR1 PIT1 Homo sapiens (Human) biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] membrane [GO:0016020]; plasma membrane [GO:0005886] high-affinity phosphate:sodium symporter activity [GO:0005316]; phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436] AEMGLGDRK;AKEGEQK;LTWPNADSKKR;VGSVVSVGWLRSKK 4 6 0.9766 -4.9799 0 0 0 0 0 0 11.8544 0 0 0 0 0 Q8WUP2 FBLI1_HUMAN Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) FBLIM1 FBLP1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623] cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725] filamin binding [GO:0031005]; metal ion binding [GO:0046872] NFHENCYRCEDCR 1 3.5 0.83733 -0.033095 0 0 3.56071 0 0 0 0 0 0 0 0 0 Q8WUP2 FBLI1_HUMAN Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) FBLIM1 FBLP1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623] cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725] filamin binding [GO:0031005]; metal ion binding [GO:0046872] GGWITRSGDR 1 2.7 0.88523 -0.1822 0 0 12.0553 0 0 0 0 0 0 0 0 0 Q8WUQ7 CATIN_HUMAN Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) CACTIN C19orf29 Homo sapiens (Human) "cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] ARSWSPSSSASSSASPGR;FFNRVHTGFEWNK;IVNREWEYSHRHGFR;YRYRRPGPCWRPIR 4 6.4 0.97646 -2.285 9.60546 0 0 0 0 0 11.694 0 0 10.9506 0 10.2715 Q8WUR7 CO040_HUMAN UPF0235 protein C15orf40 C15orf40 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] LLCAEMPK 1 5.2 0.93364 -0.49992 0 0 0 0 0 0 0 11.4111 0 0 0 0 Q8WUS8 D42E1_HUMAN Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) SDR42E1 HSPC105 Homo sapiens (Human) steroid biosynthetic process [GO:0006694] membrane [GO:0016020] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" GTDNILQVCQRRR 1 3.3 0.95763 -1.0206 0 0 0 9.46807 0 0 0 0 0 0 0 0 Q8WUT4 LRRN4_HUMAN Leucine-rich repeat neuronal protein 4 (Neuronal leucine-rich repeat protein 4) (NLRR-4) LRRN4 C20orf75 Homo sapiens (Human) long-term memory [GO:0007616]; visual learning [GO:0008542] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] LTSLYLR;SISSPQPGQR 2 2.3 0.96006 -1.0481 10.5004 0 0 0 0 0 0 0 0 0 0 0 Q8WUU4 ZN296_HUMAN Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) ZNF296 ZNF342 Homo sapiens (Human) negative regulation of dendrite development [GO:2000171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] LGPFSPK;MPKSGGK 2 2.9 0.93813 -0.57499 10.9333 0 0 0 0 0 0 10.2504 0 0 0 0 Q8WUW1 BRK1_HUMAN Protein BRICK1 (BRK1) BRK1 C3orf10 HSPC300 MDS027 Homo sapiens (Human) actin filament organization [GO:0007015]; cell motility [GO:0048870]; fibroblast proliferation [GO:0048144]; in utero embryonic development [GO:0001701]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of protein-containing complex assembly [GO:0031334]; Rac protein signal transduction [GO:0016601]; regulation of actin polymerization or depolymerization [GO:0008064] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] KIADFLNSFDMSCRSR 1 21.3 0.84982 -0.075669 0 0 0 0 0 0 0 4.95345 0 0 0 0 Q8WUX1 S38A5_HUMAN Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2) SLC38A5 JM24 SN2 SNAT5 PP7194 Homo sapiens (Human) amino acid export across plasma membrane [GO:0032973]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; asparagine transmembrane transport [GO:1903713]; glutamine transport [GO:0006868]; glycine transport [GO:0015816]; L-alanine transmembrane transport [GO:1904557]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine transmembrane transport [GO:0089709]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neutral amino acid transport [GO:0015804]; serine transport [GO:0032329]; transport across blood-brain barrier [GO:0150104] plasma membrane [GO:0005886] "alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; glycine transmembrane transporter activity [GO:0015187]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-serine transmembrane transporter activity [GO:0015194]; neutral amino acid, sodium:proton antiporter activity [GO:0140893]" GNLLIIIVSVLIILPLALMK;LAVLLAVTLTVPVVLFPIRR 2 8.5 0.070492 0.42289 0 0 0 0 6.25923 0 5.95887 0 5.20159 0 7.46164 0 Q8WUX2 CHAC2_HUMAN Glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2) CHAC2 Homo sapiens (Human) glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751] cytoplasm [GO:0005737]; cytosol [GO:0005829] gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928] LVGYITNYSR 1 5.4 0.91594 -0.33883 0 0 0 9.74861 0 0 0 0 0 10.1675 0 0 Q8WUX9 CHMP7_HUMAN Charged multivesicular body protein 7 (Chromatin-modifying protein 7) CHMP7 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex disassembly [GO:1904903]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein localization to chromatin [GO:0071168]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EVNSTDWDSK 1 2.2 0.80163 0.014438 0 0 0 6.67709 0 0 0 0 0 0 0 0 Q8WUY1 THEM6_HUMAN Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6) THEM6 C8orf55 PSEC0098 Homo sapiens (Human) extracellular region [GO:0005576] EADFARVAHLTR 1 5.8 0.94615 -0.65188 0 0 0 0 0 0 0 0 0 0 0 10.4824 Q8WUY3 PRUN2_HUMAN Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) PRUNE2 BMCC1 BNIPXL C9orf65 KIAA0367 Homo sapiens (Human) apoptotic process [GO:0006915] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793] metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462] LDQIKEKDSR;LTLSEGHPETPVDGDLGK;MPGLGWMKK;QTAPDSLDLWNR;TSCLYNDPEMSSMEK;YVSVPEK 6 2.3 0.9786 -2.0747 9.59386 0 0 0 0 11.0088 11.8043 12.2223 4.04701 0 0 0 Q8WUY8 NAT14_HUMAN Probable N-acetyltransferase 14 (EC 2.3.1.-) (K562 cell-derived leucine-zipper-like protein 1) NAT14 KLP1 Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; positive regulation of DNA-templated transcription [GO:0045893] membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080] VTRLSVSRWHR 1 5.3 0.96112 -1.0642 0 0 0 0 0 0 0 0 0 0 0 12.9525 Q8WUY9 DEP1B_HUMAN DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) DEPDC1B XTP8 Homo sapiens (Human) cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; positive regulation of Wnt signaling pathway [GO:0030177] GTPase activator activity [GO:0005096] LKQFQKSYPEVYQER;VAVEAFQICCLLLPPENR 2 6.2 0.8494 -0.077772 0 0 0 0 0 9.65614 6.82833 0 0 0 0 0 Q8WV16 DCAF4_HUMAN DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) DCAF4 WDR21 WDR21A Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] VGGSKYGIINLQSLKTPTLK 1 4 0.47116 0.19077 0 0 0 0 0 0 0 0 0 0 6.52723 0 Q8WV22 NSE1_HUMAN Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27) NSMCE1 HSPC333 HSPC337 Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] YFQSNAEPR 1 3.4 0.9127 -0.32196 0 0 0 0 0 0 7.70943 0 0 0 0 0 Q8WV24 PHLA1_HUMAN Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein) PHLDA1 PHRIP TDAG51 Homo sapiens (Human) apoptotic process [GO:0006915]; FasL biosynthetic process [GO:0045210]; positive regulation of apoptotic process [GO:0043065] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phosphatidylinositol phosphate binding [GO:1901981] ELHFSNMK 1 2 0.93536 -0.53462 0 0 0 10.4486 0 0 0 0 11.2549 0 0 0 Q8WV28 BLNK_HUMAN B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH SLP65 Homo sapiens (Human) B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] KPTTPLK;QEAVQSPVFPPAQK;SPPPAAPSPLPRAGK;TLPSKPSWPSEK 4 10.5 0.97337 -2.5547 0 10.6686 10.6876 0 0 10.3232 0 0 0 0 9.83722 0 Q8WV37 ZN480_HUMAN Zinc finger protein 480 ZNF480 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AKESGMALPQGHLTFR;IYTGEKPYKCDECGKAFYR;MLCDEKAQKR 3 8.4 0.9272 -0.45539 0 9.13437 0 3.35064 0 0 0 0 0 0 9.16189 0 Q8WV41 SNX33_HUMAN Sorting nexin-33 (SH3 and PX domain-containing protein 3) SNX33 SH3PX3 SH3PXD3C SNX30 Homo sapiens (Human) cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; mitotic cytokinesis [GO:0000281]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] IAETYSIEMGPRGPQWK 1 3 0.94205 -0.61603 0 0 0 0 0 0 11.5808 11.3564 0 0 0 0 Q8WV44 TRI41_HUMAN E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) TRIM41 RINCK Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AGAAASR;KMSRMFCQAAR 2 2.9 0.87295 -0.10887 0 0 0 0 0 10.2555 5.01725 0 0 0 0 0 Q8WV60 PTCD2_HUMAN "Pentatricopeptide repeat-containing protein 2, mitochondrial" PTCD2 Homo sapiens (Human) kidney development [GO:0001822]; liver development [GO:0001889]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; muscle cell development [GO:0055001]; regulation of gene expression [GO:0010468]; regulation of mRNA processing [GO:0050684]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] mitochondrion [GO:0005739] RNA binding [GO:0003723] EFQQKKVAVACNLSGTK 1 4.4 0.84839 -0.076669 0 0 0 0 0 0 0 10.7828 0 0 0 0 Q8WV83 S35F5_HUMAN Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3) SLC35F5 NS5ATP3 UNQ2545/PRO6097 Homo sapiens (Human) membrane [GO:0016020] RHRGAGRPGVLSSSPPFR 1 3.4 0.86004 -0.082563 0 0 0 0 0 0 0 0 0 0 8.31093 0 Q8WV92 MITD1_HUMAN MIT domain-containing protein 1 MITD1 Homo sapiens (Human) midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; negative regulation of protein binding [GO:0032091] extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; midbody [GO:0030496] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904] EDGKYHKQIK;YLDQEKEDGK 2 6.4 0.7673 0.058586 0 0 0 0 0 0 11.964 0 0 0 0 7.31016 Q8WV93 AFG1L_HUMAN AFG1-like ATPase (Lactation elevated protein 1) (EC 3.6.-.-) (Protein AFG1 homolog) AFG1L AFG1 LACE1 Homo sapiens (Human) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]" cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] FITLIDNFYDLK;QNDLTRPRILK 2 4.8 0.93766 -0.55981 0 0 0 0 0 0 0 10.0664 0 7.66342 0 0 Q8WVB6 CTF18_HUMAN Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) CHTF18 C16orf41 CTF18 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] GLFSVWQEVFQLPR;MRRAEASAR;VVQGLFDNFLRLR 3 3.7 0.97237 -2.7608 0 0 0 0 0 0 0 11.2892 0 0 0 0 Q8WVC0 LEO1_HUMAN RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) LEO1 RDL Homo sapiens (Human) endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; centrosome [GO:0005813]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] KYVISDEEEEDDD;SDQSDDEK 2 3.2 0.87968 -0.15569 0 0 9.3792 0 0 0 0 0 0 0 0 4.86918 Q8WVC6 DCAKD_HUMAN Dephospho-CoA kinase domain-containing protein DCAKD Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140] DTQLARLMR;VLGDLIFNQPDRR;YVILDIPLLFETKKLLK 3 16.9 0.8791 -0.14311 0 6.80774 0 9.39391 3.11071 0 8.57281 0 0 0 0 0 Q8WVD5 RN141_HUMAN RING finger protein 141 (Zinc finger protein 230) RNF141 ZNF230 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] LPEKVAK 1 3 0.70988 0.15931 6.68187 0 0 0 0 0 0 0 0 0 0 0 Q8WVF1 OSCP1_HUMAN Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) OSCP1 C1orf102 NOR1 Homo sapiens (Human) xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] MFNNKGEEVKR 1 2.8 0.8647 -0.089636 0 0 0 0 8.64328 0 0 0 0 0 0 0 Q8WVF2 UCMA_HUMAN Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C) (Gla-rich protein) (GRP)] UCMA C10orf49 Homo sapiens (Human) embryonic skeletal system development [GO:0048706]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; osteoblast differentiation [GO:0001649] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] BMP binding [GO:0036122] DEVNVENRQKLR 1 8.7 0.76759 0.057282 0 0 0 0 0 0 0 0 0 9.70684 0 0 Q8WVH0 CPLX3_HUMAN Complexin-3 (Complexin III) (CPX III) CPLX3 Nbla11589 Homo sapiens (Human) insulin secretion [GO:0030073]; modulation of chemical synaptic transmission [GO:0050804]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601] cytosol [GO:0005829]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] neurotransmitter transmembrane transporter activity [GO:0005326]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] DKAQATLGDLKQSAEK;EEYEEYQK;NLTGSLGGGEDK 3 22.8 0.98053 -1.7813 7.54458 0 8.09265 0 0 0 0 0 0 0 0 0 Q8WVK7 SKA2_HUMAN Spindle and kinetochore-associated protein 2 (Protein FAM33A) SKA2 FAM33A Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of meiotic spindle orientation [GO:0051296]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly involved in female meiosis [GO:0007056] cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; outer kinetochore [GO:0000940]; SKA complex [GO:0170027]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] LIILIQQVSCHH;VEFPPPAPK 2 28 0.9638 -1.1844 0 0 0 0 0 10.1546 0 0 0 0 0 0 Q8WVM0 TFB1M_HUMAN "Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)" TFB1M CGI-75 Homo sapiens (Human) rRNA methylation [GO:0031167]; rRNA modification [GO:0000154]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] "DNA binding [GO:0003677]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; S-adenosyl-L-methionine binding [GO:1904047]" LLELADIDPTLRPR;LPPLPTIREIIK;LTDKIVR;QRSRLSVMAQYLCNVR 4 14.2 0.97401 -2.9985 0 6.71466 10.7689 0 0 0 0 0 0 8.56335 0 0 Q8WVM7 STAG1_HUMAN Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) STAG1 SA1 SCC3 Homo sapiens (Human) cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682] ERKTQIDDR;ETLSKTRQIDK;LEDLNRK;LFSRHDPQAEEALAKR;TGMNYMK;TVHSYLEKFLTEQMMERR;YVGWTLHDRQGEVR 7 6.5 0.97467 -3.1185 0 0 0 0 0 9.98485 11.2258 0 0 0 8.26754 0 Q8WVM8 SCFD1_HUMAN Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23 Homo sapiens (Human) "cell morphogenesis [GO:0000902]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905] AAAAAATAAAAASIR;ARKLDVYFEYEEK;NLVLKQQNLPVTR 3 6.4 0 27.187 0 0 7.81877 9.44857 0 10.0385 11.8886 12.4791 12.0501 10.5112 9.31107 12.4023 Q8WVN8 UB2Q2_HUMAN Ubiquitin-conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) UBE2Q2 Homo sapiens (Human) protein K48-linked ubiquitination [GO:0070936] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] NQYNLARAQQSYNSIVQIHEK;VQFGANK 2 7.5 0.94605 -0.65367 11.9547 0 0 0 0 0 0 0 0 0 0 0 Q8WVP5 TP8L1_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta) TNFAIP8L1 Homo sapiens (Human) negative regulation of TOR signaling [GO:0032007]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737] identical protein binding [GO:0042802] RVLAAGLLECR;VALKLGLLLRGDQLGGEELALLR 2 18.3 0.91171 -0.32314 0 0 3.13627 0 0 0 0 0 0 0 8.99557 0 Q8WVQ1 CANT1_HUMAN Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) CANT1 SHAPY Homo sapiens (Human) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteoglycan biosynthetic process [GO:0030166] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] ADP phosphatase activity [GO:0043262]; calcium ion binding [GO:0005509]; GDP phosphatase activity [GO:0004382]; protein homodimerization activity [GO:0042803]; UDP phosphatase activity [GO:0045134] LYVGGLGK 1 2 0.93726 -0.56567 9.86037 0 0 0 0 0 0 0 0 0 0 0 Q8WVR3 TPC14_HUMAN Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) TRAPPC14 C7orf43 MAP11 Homo sapiens (Human) cilium assembly [GO:0060271]; regulation of cell population proliferation [GO:0042127] centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; TRAPPII protein complex [GO:1990071] alpha-tubulin binding [GO:0043014] IAKRECK;LPPGTPK;NHLYLGETVRFLLVLR;RNHLYLGETVR;SGSVMERR;SPVRTYER 6 8.1 0.97485 -3.226 9.7705 8.37095 0 0 4.78021 0 10.0912 6.88557 0 0 0 0 Q8WVR3 TPC14_HUMAN Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) TRAPPC14 C7orf43 MAP11 Homo sapiens (Human) cilium assembly [GO:0060271]; regulation of cell population proliferation [GO:0042127] centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; TRAPPII protein complex [GO:1990071] alpha-tubulin binding [GO:0043014] CSVCWSLFLPPGKQLCEEER;IAKRECK;SGSVMERR 3 17.6 0.81851 -0.01737 0 0 0 0 0 0 6.01988 0 0 0 0 0 Q8WVS4 DC2I1_HUMAN Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) DYNC2I1 WDR60 Homo sapiens (Human) cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] GERDRDR;SEEKDEDSERGDEDR;SNSFSDK;SNSFSDKGEER 4 3.1 0.97948 -2.0432 0 0 10.5885 8.47707 6.9222 0 0 0 0 0 8.76158 0 Q8WVT3 TPC12_HUMAN Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) TRAPPC12 TRAMM TTC15 CGI-87 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] AVATQQRGAVFVDK;ILHAELQQYLGNPQESLDRLHKVK;LLTAHGQGYGK;QVLNADSVEQSFVGLKQLISCRNWR;TAEKYFQDVEKVTQK 5 12.1 0.97401 -1.4127 0 0 0 6.40359 9.39849 8.13042 0 0 0 8.21704 0 0 Q8WVV4 POF1B_HUMAN Protein POF1B (Premature ovarian failure protein 1B) POF1B Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; bicellular tight junction assembly [GO:0070830]; epithelial cell morphogenesis [GO:0003382] actin filament [GO:0005884]; adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; desmosome [GO:0030057] actin filament binding [GO:0051015] EGSCSDFQFKLHELTSLLEEK;LRSQLNQYHKDVSK;LTTYPQTTIR;SQLNQYHKDVSK 4 7.6 0.97407 -3.0458 0 0 0 0 11.0701 9.85485 10.1571 0 0 0 0 0 Q8WVV5 BT2A2_HUMAN Butyrophilin subfamily 2 member A2 BTN2A2 BT2.2 BTF2 Homo sapiens (Human) ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] EIAQQLQEELRWR;VGTHQSL 2 3.8 0.95187 -0.74575 0 0 7.04636 0 0 0 0 9.72105 0 0 0 0 Q8WVV9 HNRLL_HUMAN Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) HNRNPLL HNRPLL SRRF BLOCK24 Homo sapiens (Human) mRNA processing [GO:0006397]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484] membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] mRNA binding [GO:0003729]; RNA binding [GO:0003723] LLERSPL 1 2.5 0.89889 -0.25768 10.8072 9.99308 9.63633 0 0 0 0 10.7229 10.9083 10.6203 10.6171 0 Q8WVX9 FACR1_HUMAN Fatty acyl-CoA reductase 1 (FAR1) (EC 1.2.1.84) (Male sterility domain-containing protein 2) FAR1 MLSTD2 UNQ2423/PRO4981 Homo sapiens (Human) ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491] HIDEVVYPPPVDPK 1 2.7 0.78453 0.020168 0 0 0 0 0 0 0 0 0 0 9.56533 0 Q8WVZ7 RN133_HUMAN E3 ubiquitin-protein ligase RNF133 (EC 2.3.2.27) (RING finger protein 133) (RING-type E3 ubiquitin transferase RNF133) RNF133 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LTTDLQNTFGQLQLR;VGTWRNNTASSWLMK 2 8 0.89697 -0.2491 0 0 0 0 0 0 0 9.4779 0 0 9.71613 0 Q8WVZ9 KBTB7_HUMAN Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VYNPARGEWRR 1 1.6 0.86954 -0.091208 0 0 0 0 0 6.90821 0 0 0 0 0 0 Q8WW14 SMIP5_HUMAN Sperm-associated microtubule inner protein 5 SPMIP5 C10orf82 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634] ELCCAVATAPK 1 10 0.93668 -0.55922 0 0 0 0 0 0 11.4481 0 0 0 0 0 Q8WW18 CQ050_HUMAN Uncharacterized protein C17orf50 C17orf50 Homo sapiens (Human) VAEEGEGRER 1 5.7 0.88611 -0.18206 0 0 0 0 0 0 0 0 0 7.62644 0 0 Q8WW22 DNJA4_HUMAN DnaJ homolog subfamily A member 4 DNAJA4 Homo sapiens (Human) negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of gene expression [GO:0010628]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] GHDLIMKMK 1 2.3 0.97984 -1.5669 0 0 12.9929 0 0 0 0 0 0 0 0 0 Q8WW24 TEKT4_HUMAN Tektin-4 TEKT4 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] ETCEMDWSDK;NLEDIHMSLEK;YLLEEWFQNCYAR 3 7.8 0.93691 -0.54955 0 0 0 0 0 0 0 11.3242 0 5.54945 9.38705 0 Q8WW32 HMGB4_HUMAN High mobility group protein B4 HMGB4 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" ATGKMWSTATDLEK;MGKEIQLKPKANVSSYVHFLLNYR 2 20.4 0.90326 -0.26445 0 0 0 7.47395 0 0 0 0 0 6.02283 0 0 Q8WW34 TM239_HUMAN Transmembrane protein 239 TMEM239 Homo sapiens (Human) membrane [GO:0016020] RVGTWICLPGRPGR 1 7.2 0.64081 0.17239 12.4973 0 0 0 0 0 0 0 0 0 0 0 Q8WW38 FOG2_HUMAN Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) ZFPM2 FOG2 ZNF89B Homo sapiens (Human) cell differentiation [GO:0030154]; embryonic organ development [GO:0048568]; fat cell differentiation [GO:0045444]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of female gonad development [GO:2000195]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] DASSDTELDK;LCDIQFNNLSNFITHKK;VENYLAHK 3 3 0.94009 -0.58027 8.93867 0 0 9.20904 0 0 0 0 0 0 10.1094 0 Q8WW59 SPRY4_HUMAN SPRY domain-containing protein 4 SPRYD4 Homo sapiens (Human) mitochondrion [GO:0005739]; nucleus [GO:0005634] DDTGVKYGLVGLEPTK 1 7.7 0.91594 -0.43121 0 0 0 10.148 0 0 0 0 0 0 0 0 Q8WW62 TMED6_HUMAN Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5) TMED6 UNQ9146/PRO34237 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794] VQNNIFHMWR 1 4.2 0.89839 -0.23321 0 0 8.73782 0 0 0 0 0 0 0 0 0 Q8WWA0 ITLN1_HUMAN Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin) ITLN1 INTL ITLN LFR UNQ640/PRO1270 Homo sapiens (Human) positive regulation of D-glucose import [GO:0046326]; positive regulation of protein phosphorylation [GO:0001934]; protein homotrimerization [GO:0070207]; response to nematode [GO:0009624] brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; receptor complex [GO:0043235]; side of membrane [GO:0098552] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492] SPMQHWR 1 2.2 0.94028 -0.58436 9.7075 0 0 0 0 0 0 0 0 0 0 0 Q8WWC4 MAIP1_HUMAN "m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1)" MAIP1 C2orf47 Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ribosome binding [GO:0043022] AFLIWAYFDK;SLPCGAVR 2 6.2 0.93621 -0.55185 0 0 0 0 0 0 0 0 0 9.15864 0 0 Q8WWH4 ASZ1_HUMAN "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Ankyrin-like protein 1) (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 ALP1 ANKL1 C7orf7 GASZ Homo sapiens (Human) cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526] cytoplasm [GO:0005737]; pi-body [GO:0071546] DLIQKLQNERENDPTHIQLR;LEISGDEFLNFLLKLNKQCGHLITAVQNVITELPVNSQK;NKHHEIFNLLSFTLNPLEGK 3 16.6 0.87582 -0.12856 6.43884 0 0 0 0 0 8.66381 0 0 0 0 7.32876 Q8WWH5 TRUB1_HUMAN Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) TRUB1 PUS4 Homo sapiens (Human) mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of pre-miRNA processing [GO:2000633]; tRNA modification [GO:0006400] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] pre-miRNA binding [GO:0070883]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine(55) synthase activity [GO:0160148] AALATKLLSLSGVFAVHKPK;GVLVVGIGSGTKMLTSMLSGSK;KDGQRLSTLMK;REDDVIKTC;RYTAIGELGKATDTLDSTGR 5 23.5 0.97508 -2.3687 0 0 0 9.81153 0 0 9.66493 0 12.3088 0 0 10.4258 Q8WWI1 LMO7_HUMAN LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) LMO7 FBX20 FBXO20 KIAA0858 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] ALEDSSFLK;GISSLPR;GISSLPRSYTMDDAWK;ILVPSYRQK;ISAVEPK;ISINQTPGK;ISINQTPGKSLDFGFTIK;KFSEQDDSVER;LKPGVIKKINR;QAEIERETSVR;SRSTQMESTRVSASLPR 11 6.5 0.97792 -6.158 11.3925 12.395 8.94524 6.35209 10.332 0 11.0893 7.20867 9.802 11.655 10.293 0 Q8WWI5 CTL1_HUMAN Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92) SLC44A1 CD92 CDW92 CTL1 Homo sapiens (Human) choline catabolic process [GO:0042426]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228] EIILGLCLLSLVLSMILMVIIR;KYVFFLDPCNLDLINR;LISGVMTSK;VLVWILTILVILGSLGGTGVLWWLYAK 4 11.3 0.93705 -0.56791 0 0 5.33063 0 0 10.6248 0 6.42156 0 11.3482 3.46166 0 Q8WWK9 CKAP2_HUMAN Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) CKAP2 LB1 TMAP Homo sapiens (Human) apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] DHYPCVSSLEQLTELGR;SAQPKETSEERK;TPNTETRTSCLIK 3 6.1 0.83592 -0.034505 11.3286 11.6644 0 4.18285 0 0 0 0 0 5.73839 6.06078 0 Q8WWL2 SPIR2_HUMAN Protein spire homolog 2 (Spir-2) SPIRE2 KIAA1832 SPIR2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; microtubule binding [GO:0008017] AELDSLGHTDWAR;DVCSECTSFVADVVR;FGHIPVYTLGFESPQR;FLQNKELFSSLK;GLRGSPGR;SVRTFAQAMRLCAAR 6 11.1 0.97993 -1.8739 11.5619 0 0 5.03879 0 0 0 4.4452 0 0 10.2594 10.6033 Q8WWL2 SPIR2_HUMAN Protein spire homolog 2 (Spir-2) SPIRE2 KIAA1832 SPIR2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; microtubule binding [GO:0008017] AELDSLGHTDWAR;DVCSECTSFVADVVR;FGHIPVYTLGFESPQR;FLQNKELFSSLK;MANNDSEDSGCGAADEGYGGPEEEEEAEGVPR;SVRTFAQAMRLCAAR 6 17.7 0.71102 0.15721 0 0 0 0 5.9373 0 0 0 0 0 0 0 Q8WWL7 CCNB3_HUMAN G2/mitotic-specific cyclin-B3 CCNB3 CYCB3 Homo sapiens (Human) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; meiotic cell cycle [GO:0051321] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] CDINIPIAYHFLRR;EEPTIEDETLINK;ELSFKEPLALQESPTCK;EPSVDTEAHFK;ESLDLQEKPSIK;FLSQEPSALKEK;LLTFSSYDSLK 7 6.5 0.9729 -1.3691 0 2.66903 4.32632 10.4172 0 0 11.2344 0 8.8437 8.73237 9.1631 8.8049 Q8WWM1 XAGE5_HUMAN X antigen family member 5 (XAGE-5) (Cancer/testis antigen 12.5) (CT12.5) (G antigen family D member 5) XAGE5 GAGED5 Homo sapiens (Human) TGDECGDSPDVQGKILPK 1 16.7 0.87349 -0.11088 0 0 12.537 0 0 4.51368 12.5951 12.5264 0 10.4996 0 0 Q8WWM7 ATX2L_HUMAN Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) ATXN2L A2D A2LG A2LP A2RP Homo sapiens (Human) mRNA metabolic process [GO:0016071]; stress granule assembly [GO:0034063] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GINGGPSR;NGTTYEGIFK;NVDFNYATK;TLEPQELAR 4 3.3 0.97453 -2.4044 0 0 0 0 0 0 0 9.35883 0 0 0 0 Q8WWN8 ARAP3_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)" ARAP3 CENTD3 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]" AGPSPPR;FQVITGQRVFVFR;GVIPLTAIEMTRSSK;SLRLLAEFR;VQKCAALNQMCTR 5 3.7 0.97534 -3.3622 0 0 10.1491 9.77152 6.37929 0 12.7502 0 0 0 8.06711 0 Q8WWN9 ICEF1_HUMAN Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) IPCEF1 KIAA0403 Homo sapiens (Human) oxygen transport [GO:0015671]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] CKNPSINEKLHK;KHAFKISHPQIK 2 5.5 0.96489 -1.1681 0 3.67649 0 0 7.5806 0 0 0 0 0 0 0 Q8WWP7 GIMA1_HUMAN GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1) GIMAP1 IMAP1 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] GTP binding [GO:0005525] KMATDEENVYGLEENAQSR;SATGNSILGQRRFFSR 2 11.4 0.74051 0.10812 0 0 0 0 0 5.83213 0 0 3.4518 0 0 0 Q8WWQ0 PHIP_HUMAN PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) PHIP DCAF14 WDR11 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; insulin receptor signaling pathway [GO:0008286]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] insulin receptor binding [GO:0005158]; lysine-acetylated histone binding [GO:0070577] ASTLSKSSAVIEQGDCK;EQELMKIVGIKYEVGLPTLCCLK;QQTNQHNYR;RILKPQLK;TQKLDADLLVPASVK 5 4 0.97445 -3.7741 0 0 0 0 9.11736 0 0 0 9.61025 10.4688 0 0 Q8WWQ2 HPSE2_HUMAN Inactive heparanase-2 (Hpa2) HPSE2 HPA2 Homo sapiens (Human) cell population proliferation [GO:0008283]; extracellular matrix organization [GO:0030198]; positive regulation of cell population proliferation [GO:0008284] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparan sulfate proteoglycan binding [GO:0043395]; heparanase activity [GO:0030305] LIGPKVLAVHVAGLQRKPRPGR;NYEDEPNNYRTMHGR;RLVTLARGLSPAFLR;RPLPVDRAAGLKEK 4 13.8 0.97721 -1.5229 5.9028 0 0 0 4.53897 7.69843 0 0 0 0 0 0 Q8WWQ8 STAB2_HUMAN "Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)]" STAB2 FEEL2 FELL FEX2 HARE Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; endocytosis [GO:0006897]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898] cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044] CLCVHGTCNNR;NGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCR;QDNGGCAK;VLSLEEDVLR 4 2.5 0.98011 -1.6692 0 0 0 0 0 0 0 0 0 8.6327 0 5.4445 Q8WWR8 NEUR4_HUMAN Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) NEU4 LP5125 Homo sapiens (Human) ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; negative regulation of neuron projection development [GO:0010977]; oligosaccharide catabolic process [GO:0009313] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; organelle inner membrane [GO:0019866]; plasma membrane [GO:0005886] exo-alpha-sialidase activity [GO:0004308] MSSAAFPRWLQSMGVPR;TVLFERER;TVLFERERTGLTYR 3 6.2 0.98058 -1.6583 0 0 10.3029 0 0 0 8.96798 0 0 0 0 11.326 Q8WWR9 PDPFL_HUMAN Pancreatic progenitor cell differentiation and proliferation factor-like protein (Exocrine differentiation and proliferation factor-like protein) PPDPFL C8orf22 Homo sapiens (Human) cell differentiation [GO:0030154] IKDLSATGSLSGR;MASVPSIGCLLAR 2 31 0.97927 -1.5408 0 0 0 0 0 0 0 11.5666 0 0 0 0 Q8WWT9 S13A3_HUMAN Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3) SLC13A3 NADC3 SDCT2 Homo sapiens (Human) citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; glutathione transmembrane transport [GO:0034775]; lipid transport [GO:0006869]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; glutathione transmembrane transporter activity [GO:0034634]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] DPSQESEENTAAVR;LLVLLFTPLALLPVVFALPPK;RLLVLLFTPLALLPVVFALPPK 3 6 0.067769 0.42786 0 0 0 0 7.41878 7.03078 0 4.45759 0 7.27015 0 0 Q8WWU5 TCP11_HUMAN T-complex protein 11 homolog TCP11 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; germ cell development [GO:0007281]; protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] EIKEILLSLLLPRQNR;EILLSLLLPRQNRLR 2 3.6 0.88202 -0.16487 0 0 5.14131 0 4.27284 0 0 0 0 9.38974 0 0 Q8WWV3 RT4I1_HUMAN "Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)" RTN4IP1 NIMP Homo sapiens (Human) nervous system development [GO:0007399]; regulation of dendrite development [GO:0050773]; ubiquinone biosynthetic process [GO:0006744] mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] NADPH dehydrogenase (quinone) activity [GO:0008753]; zinc ion binding [GO:0008270] FTQNMMMPIIHYPNEVIVK;GVHYRWAFFMASGPCLDDIAELVDAGK;ISTTSPR;VGGLNDK 4 15.2 0.97968 -1.5651 0 0 0 0 0 9.6209 0 0 0 0 11.9842 0 Q8WWW0 RASF5_HUMAN Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL) RASSF5 NORE1 RAPL Homo sapiens (Human) apoptotic process [GO:0006915]; lymphocyte proliferation [GO:0046651]; negative regulation of lymphocyte proliferation [GO:0050672]; positive regulation of protein ubiquitination [GO:0031398]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] EVNLAATTDKR;KFMVVDNPQKFALFK;QKIDSYNTREK 3 8.9 0.98141 -1.5899 0 12.0914 0 0 0 0 0 0 11.2562 0 0 5.92431 Q8WWX8 SC5AB_HUMAN Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11) SLC5A11 KST1 SLGTX SMIT2 Homo sapiens (Human) apoptotic process [GO:0006915]; myo-inositol transport [GO:0015798] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; polyol transmembrane transporter activity [GO:0015166] GAFWGLISGLLLGLVRLVLDFIYVQPR;GGALMAAYLK;ILFPDQVACADPEICQK;RFGGIRIPIILAVLYLFIYIFTK 4 11.4 0.91478 -0.38016 0 0 0 5.79924 9.5183 0 0 0 0 0 0 10.3453 Q8WWX9 SELM_HUMAN Selenoprotein M (SelM) SELENOM SELM Homo sapiens (Human) adipose tissue development [GO:0060612]; corticosterone secretion [GO:0035934]; hormone metabolic process [GO:0042445]; multicellular organism growth [GO:0035264]; response to selenium ion [GO:0010269] endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] oxidoreductase activity [GO:0016491] VETCGGUQLNRLK 1 9 0.92085 -0.44634 8.52093 8.77969 0 0 0 0 0 0 0 0 0 0 Q8WWY3 PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) PRPF31 PRP31 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; ribonucleoprotein complex localization [GO:0071166]; spliceosomal tri-snRNP complex assembly [GO:0000244]" Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] QTQVNEATK;SGSGRVR;TLQRTLQKQSVVYGGK 3 6.4 0.97978 -1.9963 0 0 0 0 8.4121 0 0 0 0 0 11.197 0 Q8WWY6 MB3L1_HUMAN Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1) MBD3L1 MBD3L Homo sapiens (Human) DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] methyl-CpG binding [GO:0008327] DQEGRPEKR 1 4.6 0.78301 0.030926 0 0 0 0 0 0 9.01809 0 0 0 0 0 Q8WWY8 LIPH_HUMAN Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B) LIPH LPDLR MPAPLA1 PLA1B Homo sapiens (Human) lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; phospholipase activity [GO:0004620] GDITIKLR;VAAISLMFSTGSLIGPRYK 2 6 0.95641 -0.99409 0 0 0 0 0 10.598 11.9037 0 0 0 0 0 Q8WWZ1 IL1FA_HUMAN Interleukin-1 family member 10 (IL-1F10) (Family of interleukin 1-theta) (FIL1 theta) (Interleukin-1 HY2) (IL-1HY2) (Interleukin-1 theta) (IL-1 theta) (Interleukin-38) (IL-38) IL1F10 FIL1T IL1HY2 IL38 FKSG75 UNQ6119/PRO20041 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response to antigenic stimulus [GO:0002437]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] MCSLPMARYYIIKYADQK;YYIIKYADQKALYTR 2 15.1 0.73091 0.11492 0 0 0 0 0 0 0 9.94212 0 0 0 6.58165 Q8WWZ4 ABCAA_HUMAN ATP-binding cassette sub-family A member 10 (EC 7.6.2.-) ABCA10 Homo sapiens (Human) lipid transport [GO:0006869] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] ALLCLLLVLGIAFIPIILEKIMYK;IDTTVEWK;LSGGQKR;MIATFFILAFDTLFYLIFTLYFER;TLSEGIKRK 5 4.7 0.96554 -1.2439 0 0 11.8913 10.127 9.5623 9.63258 11.9351 11.1559 10.1881 0 8.51396 9.97241 Q8WWZ7 ABCA5_HUMAN Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5) ABCA5 KIAA1888 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; high-density lipoprotein particle remodeling [GO:0034375]; lipid transport [GO:0006869]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of reverse cholesterol transport [GO:1903064]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691] Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] LSGGQKR;QTRTLLLKNYLIK;VLLDLDMQTIK 3 1.9 0.58794 0.17874 0 0 0 0 0 0 0 0 0 9.91997 6.19348 0 Q8WWZ8 OIT3_HUMAN Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) OIT3 LZP UNQ826/PRO1753 Homo sapiens (Human) renal system process [GO:0003014] nuclear envelope [GO:0005635] calcium ion binding [GO:0005509] DHKEVFLHCRVLVCGVLDER;DNEFEEPYR 2 5.3 0.91861 -0.40211 0 7.90316 0 0 0 0 0 0 7.15664 0 0 0 Q8WX77 IBPL1_HUMAN Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4) IGFBPL1 IGFBPRP4 Homo sapiens (Human) cellular response to tumor cell [GO:0071228]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] insulin-like growth factor binding [GO:0005520] LSLLLPLLLLLLLPLLPPLSPSLGIRDVGGR;PRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGR 2 11.9 0.71449 0.14143 0 0 0 0 0 0 0 4.21039 0 0 4.14151 0 Q8WX92 NELFB_HUMAN Negative elongation factor B (NELF-B) (Cofactor of BRCA1) NELFB COBRA1 KIAA1182 Homo sapiens (Human) cell population proliferation [GO:0008283]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; stem cell differentiation [GO:0048863] cytoplasm [GO:0005737]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] FLPMLMSFLVDDYTFNVDQK;LYDMVLQFLRTLFLRTR;VSAIASEGK 3 7.9 0.095385 0.37415 0 0 10.0018 0 0 0 0 0 6.59607 0 0 0 Q8WX93 PALLD_HUMAN Palladin (SIH002) (Sarcoma antigen NY-SAR-77) PALLD KIAA0992 CGI-151 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendrite self-avoidance [GO:0070593]; epithelial cell morphogenesis [GO:0003382]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte development [GO:0003334] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; muscle alpha-actinin binding [GO:0051371] EPPPLLAKPK;GVTPAGFPK;GVTPAGFPKK;KGGPQSQLCDK;LGEHASR;SLRKAEK 6 3.3 0.97305 -2.9427 11.6905 0 0 0 0 8.17073 0 0 0 0 5.79948 0 Q8WX94 NALP7_HUMAN "NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3)" NLRP7 NALP7 NOD12 PYPAF3 Homo sapiens (Human) cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein processing [GO:0010955]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966] EVLGCLYESQEEELAK;LTHLCLAK;QSFLSDSSVR;VEGFLEEDRRAYFLR 4 5 0.96319 -1.0851 0 0 0 8.224 0 0 0 0 0 0 0 0 Q8WXA3 RUFY2_HUMAN RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related) RUFY2 KIAA1537 RABIP4R Homo sapiens (Human) regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634] metal ion binding [GO:0046872]; SH3 domain binding [GO:0017124] CASSDTQDQYK 1 2.7 0.8083 0.0088997 0 0 0 5.84077 0 0 0 0 0 0 0 0 Q8WXA8 5HT3C_HUMAN 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C) HTR3C Homo sapiens (Human) inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GNKGLGLTLTHLPGPKEPGELAGK 1 5.4 0.95499 -0.94673 0 0 0 0 0 0 0 9.95569 0 0 0 9.53984 Q8WXA9 SREK1_HUMAN "Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)" SREK1 SFRS12 SRRP86 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] ELEEVMK;LYPPDNAPLAFSSK;SHSRDKR 3 4.5 0.90914 -0.3137 0 0 11.2869 7.40514 0 0 11.2653 0 0 0 0 0 Q8WXB4 ZN606_HUMAN Zinc finger protein 606 (Zinc finger protein 328) ZNF606 KIAA1852 ZNF328 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GIHTGEK;MHTGEKPFKCDECEK 2 2.8 0.95232 -0.75383 0 6.85125 0 0 0 0 0 0 0 5.93918 0 0 Q8WXD0 RXFP2_HUMAN Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) RXFP2 GPR106 GREAT LGR8 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; protein-hormone receptor activity [GO:0016500] IFLQHNCIRHISRK;KIFLQHNCIRHISR;LITMFFLLHFIVLINVK;QYPQCCDCK 4 5.4 0.41165 0.20447 0 4.87248 0 9.41098 0 9.49695 12.7621 0 0 0 8.66583 0 Q8WXD2 SCG3_HUMAN Secretogranin-3 (Secretogranin III) (SgIII) SCG3 UNQ2502/PRO5990 Homo sapiens (Human) protein localization to secretory granule [GO:0033366] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] RNA binding [GO:0003723] SHEETDSTKEEAAKMEK 1 3.6 0.86423 -0.083961 0 0 0 0 0 0 0 0 0 5.2332 0 0 Q8WXE0 CSKI2_HUMAN Caskin-2 (CASK-interacting protein 2) CASKIN2 KIAA1139 Homo sapiens (Human) cytoplasm [GO:0005737] IGYFPPGIVEVVSKR;LSSVSGPSPEPPPLDESPGPK;TKLLGSTKR;TSPSVTPTPARGTPRSQSFALR 4 5.6 0.95574 -0.85208 7.75134 0 0 0 9.04821 0 0 0 0 0 11.4299 0 Q8WXE1 ATRIP_HUMAN ATR-interacting protein (ATM and Rad3-related-interacting protein) ATRIP AGS1 Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of double-strand break repair [GO:2000779] ATR-ATRIP complex [GO:0070310]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530] AGTSAPGSK;DGDPAEGGR;DTVLLLHGLSQK 3 3.8 0.95582 -0.87168 0 8.08444 0 0 0 0 8.67048 0 10.261 0 0 0 Q8WXF0 SRS12_HUMAN "Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)" SRSF12 SFRS13B SFRS19 SRRP35 Homo sapiens (Human) "mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal tri-snRNP complex assembly [GO:0000244]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082] DAEDALYNLNRK;SIGKSQSSSPQK;VQTAKHSHFR 3 13 0.98061 -1.6179 0 10.4658 0 0 0 9.81789 8.91166 0 0 0 9.35255 0 Q8WXF1 PSPC1_HUMAN Paraspeckle component 1 (Paraspeckle protein 1) PSPC1 PSP1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] RNA binding [GO:0003723] AVVVVDDRGRATGK;FAQPGTFEFEYASRWK;RQQEGFKPNYMENGDK;TLAEIAK 4 13.5 0.90145 -0.2618 0 0 0 0 8.50212 0 0 8.22033 7.62322 0 0 0 Q8WXF7 ATLA1_HUMAN Atlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A) ATL1 GBP3 SPG3A Homo sapiens (Human) axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; protein homooligomerization [GO:0051260] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] GVKKMGGEEFSR 1 2.2 0.86859 -0.093861 0 0 0 0 6.43291 0 0 0 0 0 0 0 Q8WXF8 DEDD2_HUMAN DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3) DEDD2 FLAME3 PSEC0004 Homo sapiens (Human) apoptotic nuclear changes [GO:0030262]; cellular homeostasis [GO:0019725]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; signaling receptor complex adaptor activity [GO:0030159] DLGSVVCDIK;GVFLTEALREAVGREAVR 2 8.6 0.93241 -0.49233 0 0 0 0 0 0 0 0 0 0 10.4088 0 Q8WXG1 RSAD2_HUMAN "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) (Viperin)" RSAD2 CIG5 Homo sapiens (Human) "CD4-positive, alpha-beta T cell activation [GO:0035710]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of protein secretion [GO:0050709]; negative regulation of viral genome replication [GO:0045071]; positive regulation of immune response [GO:0050778]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; response to virus [GO:0009615]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]" ALNPVRWK;EAERFVIGDEEFERFLER 2 7.2 0.97323 -2.5133 0 0 0 0 0 9.23881 0 0 11.9757 0 0 0 Q8WXG6 MADD_HUMAN MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) MADD DENN IG20 KIAA0358 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; execution phase of apoptosis [GO:0097194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Rab protein signal transduction [GO:0032483] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] death receptor binding [GO:0005123]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase activator activity [GO:0030295] AHSLKPSIKEKLAGSPIR;CRELYYCVK;LAGSPIR;LINMTYCPK;LNRMVQSEDDAR;RALVDQKSSVIK;RLEDDEDRLLATLLHNLISYMLLMK;RLVDCCSER;VPQLGPRAPSATGK 9 6.6 0.97677 -4.9477 0 10.6036 0 0 8.57781 0 11.897 10.6737 0 6.8125 8.70774 0 Q8WXG9 AGRV1_HUMAN Adhesion G-protein coupled receptor V1 (ADGRV1) (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) [Cleaved into: ADGRV1 subunit alpha; ADGRV1 subunit beta] ADGRV1 GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; maintenance of animal organ identity [GO:0048496]; negative regulation of adenylate cyclase activity [GO:0007194]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of bone mineralization [GO:0030501]; positive regulation of protein kinase A signaling [GO:0010739]; regulation of protein stability [GO:0031647]; self proteolysis [GO:0097264]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; periciliary membrane compartment [GO:1990075]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696] adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; hydrolase activity [GO:0016787] GDAIYSAVYDVVR;GVLTVALFNK;IFPPSVGEFAETSGK;LAVAHKKATLISLQVAR;LEWTIDEK;LEWTIDEKAK;LGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEPK;NDLIFPEQKTQVTTKLPIR;SESVFIELLNSTLVAKVQSR;SVEGGAEINTSR;TVYLNVSR;VQEGETANFTVLR 12 2.7 0.97688 -4.9069 4.03087 3.80426 4.44069 7.19032 13.2047 0 0 13.7061 10.4637 14.0343 14.0193 14.5633 Q8WXH0 SYNE2_HUMAN Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) SYNE2 KIAA1011 NUA Homo sapiens (Human) centrosome localization [GO:0051642]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]; regulation of cilium assembly [GO:1902017] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium membrane [GO:0031258]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] actin binding [GO:0003779]; cytoskeleton-nuclear membrane anchor activity [GO:0140444] ACFEETKKEEIK;AGLDYNRSYQNEIKR;AHVTDPK;AIDLQIK;AIDLQIKK;ATVKMEEYSDLLK;ATVLNLHQHLKQEQEGVER;DLENRLASAK;EIKESLMVLNSSEGK;EIQTDSWRK;ELESYMMRAQQLLGQR;FILLLEFHYYK;GLIMHEEENLDRLHQQEK;IDHELHR;IESELSKPVVYDVCDDQEIQK;IIKDDIKSLQCK;IQRFIQNTCNEVEHKIK;KPFVIKERDTLK;LETSLHVLNQIK;LFLEDQLK;LRCTENDGICLLK;LSDFLTLEGRNSK;LTAIKCCILQVLKLK;LTFENIMEKLR;LTSCTPGLEDEK;MESICQAR;MPLEERIQK;MRQLNGFQQEITLNTNK;MTLFKSLMDR;MWDELDLWHSK;NELLLNQEVNKGVKEEIYNLK;NIQDSIAK;NVIDEWTEKALQK;QLSEIEEEDK;RHLQEMANSLPHFK;RRTTCALTLEAGEK;SLAKYLK;TQIGMTESLLK;TVKCNLEK;VAFLLETCK;WLDINEK;WTMLITQLPDIQEK 42 7.2 0.97885 -13.458 12.4239 14.9286 11.5775 8.32062 11.6221 8.75138 10.1149 12.7731 13.6413 12.8043 11.5519 7.44402 Q8WXH0 SYNE2_HUMAN Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) SYNE2 KIAA1011 NUA Homo sapiens (Human) centrosome localization [GO:0051642]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]; regulation of cilium assembly [GO:1902017] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium membrane [GO:0031258]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] actin binding [GO:0003779]; cytoskeleton-nuclear membrane anchor activity [GO:0140444] AHVTDPK;EIQTDSWRK;LTSCTPGLEDEK;MRQLNGFQQEITLNTNK;MVHEGNQRWDNLQRR 5 9 0.44256 0.19387 0 0 0 0 6.43121 0 0 0 0 0 0 0 Q8WXH2 JPH3_HUMAN Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein) JPH3 JP3 TNRC22 Homo sapiens (Human) calcium ion transport into cytosol [GO:0060402]; exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167] endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886] SSLASQRSKQSSFR 1 1.9 0.86496 -0.08659 0 0 0 5.99453 0 0 0 0 0 0 0 0 Q8WXH4 ASB11_HUMAN Ankyrin repeat and SOCS box protein 11 (ASB-11) ASB11 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ACHQAIHKLHLPEPLER;IAEEIYGGISDCWADR 2 10.2 0.90185 -0.26111 0 0 0 0 0 0 0 0 7.47476 0 3.80498 7.18706 Q8WXH5 SOCS4_HUMAN Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7) SOCS4 SOCS7 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567] HSCSSIELDLDHSCGHRFLGR;KDGYVWSGK 2 6.8 0.95542 -0.88202 4.79275 0 0 0 0 0 0 0 0 0 0 0 Q8WXH6 RB40A_HUMAN Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2) RAB40A Homo sapiens (Human) exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924] TIVSCTPVHLVDK;VEIVCPPQSPPK;VLSLQDLCCR 3 12.6 0.92075 -0.44637 0 0 11.1575 0 5.49876 0 0 11.3416 8.95289 0 0 0 Q8WXI2 CNKR2_HUMAN Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) CNKSR2 CNK2 KIAA0902 KSR2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; postsynaptic specialization organization [GO:0099084]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] DSRRENSLLR;ENSLLRYMSNEK;KYWFVLKDASLYWYINEEDEK;LRPISMPVEYNWVGDYEDPNKMKR;LSFIKRCNDPVMNEK 5 7.4 0.71138 0.15571 0 0 9.6815 0 0 9.31811 0 9.91718 4.44903 0 7.06942 0 Q8WXI3 ASB10_HUMAN Ankyrin repeat and SOCS box protein 10 (ASB-10) ASB10 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] DFRFNIR;LGHVELADLLLRR;RPLHLCR 3 5.8 0.97838 -2.1458 0 0 0 0 0 6.79831 0 0 0 0 9.03392 0 Q8WXI4 ACO11_HUMAN Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2) ACOT11 BFIT KIAA0707 THEA Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; negative regulation of cold-induced thermogenesis [GO:0120163]; response to cold [GO:0009409]; response to temperature stimulus [GO:0009266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617]; lipid binding [GO:0008289]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816] VSLTELVSASGFYSWGLESR 1 3.3 0.84896 -0.07642 0 0 0 0 0 0 0 0 10.3222 0 0 0 Q8WXI7 MUC16_HUMAN Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) MUC16 CA125 Homo sapiens (Human) cell adhesion [GO:0007155] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; vesicle [GO:0031982] EVTTVMTSDISK;FLHSEMTTLMSR;IAPSESTTDK;IPNEAAHR;IPNEAAHRGTIRPVKGPQTSTSPASPK;IQKESISSLSPK;ISTPLTR;MSPYISTETITR;SISQSLGR;SLMTGSR 10 0.7 0.97518 -2.3531 0 0 0 8.46667 0 0 11.1179 0 0 8.76378 14.379 0 Q8WXI9 P66B_HUMAN Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) GATAD2B KIAA1150 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]" sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] SLDPADERDDVLAK 1 2.4 0.92052 -0.43751 0 0 0 0 0 0 0 0 10.1649 0 0 0 Q8WXJ9 ASB17_HUMAN Ankyrin repeat and SOCS box protein 17 (ASB-17) ASB17 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] EIKTQLSLGR 1 3.4 0.98156 -1.5899 0 0 0 0 0 0 0 0 0 10.0094 0 0 Q8WXQ8 CBPA5_HUMAN Carboxypeptidase A5 (EC 3.4.17.-) CPA5 Homo sapiens (Human) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AYLESHGLAYSIMIK;FSTGGSR 2 5 0.90782 -0.30668 0 0 0 10.1135 0 0 0 0 7.62417 0 0 0 Q8WXR4 MYO3B_HUMAN Myosin-IIIb (EC 2.7.11.1) MYO3B Homo sapiens (Human) cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin filament length [GO:0030832]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microfilament motor activity [GO:0000146]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HPEETTNMK;TSENKLLQQLFSIPLTKTGNLAQTR;VTNKRDGSLAAVK 3 3.5 0.91739 -0.40937 0 0 0 6.84071 7.95983 0 0 9.78432 0 12.8623 0 0 Q8WXS3 BAALC_HUMAN Brain and acute leukemia cytoplasmic protein BAALC Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528] ADAIEPR;MGCGGSR 2 9.7 0.91306 -0.38788 0 0 0 0 0 0 0 0 0 0 10.283 0 Q8WXS8 ATS14_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) ADAMTS14 Homo sapiens (Human) collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DHHMVQRHLCDHK;HLCDHKKRPKPIR;NSYYVHQNAK;RHAKPGSYSIEVLLVVDDSVVR 4 4.3 0.65973 0.16919 0 0 9.17348 0 0 0 9.60053 0 0 9.59833 0 0 Q8WXT5 FX4L4_HUMAN Forkhead box protein D4-like 4 (FOXD4-like 4) (Forkhead box protein D4-like 2) (Forkhead box protein D4B) (Myeloid factor-gamma) FOXD4L4 FOXD4B FOXD4L2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPGHPGK;VLCKGSGER;VYAGAPK 3 5.5 0.9809 -1.7003 0 0 0 0 9.22562 0 9.26651 0 11.1618 0 7.69843 0 Q8WXU2 DAAF4_HUMAN Dynein axonemal assembly factor 4 (Dyslexia susceptibility 1 candidate gene 1 protein) DNAAF4 DYX1C1 EKN1 Homo sapiens (Human) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; inner dynein arm assembly [GO:0036159]; learning or memory [GO:0007611]; neuron migration [GO:0001764]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] nuclear estrogen receptor binding [GO:0030331] EEEKNPEWLK;KEAAMWETLSVTGVDKEMMQR;VFPTALR;YALSVMMKIEEEER 4 12.4 0.95326 -0.72692 0 0 0 7.87707 0 0 0 0 7.94163 0 0 11.0981 Q8WXW3 PIBF1_HUMAN Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) PIBF1 C13orf24 PIBF Homo sapiens (Human) activation of Janus kinase activity [GO:0042976]; cilium assembly [GO:0060271]; immune system process [GO:0002376]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; non-motile cilium assembly [GO:1905515]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein localization to centrosome [GO:0071539] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634] interleukin-4 receptor binding [GO:0005136] EMYERENRNLR;ENRNLREAR;HDQLLDRYR;KEAPEWSKK;QLEETNLQLREK;TLNVPKEHEDNIFTPKPTLFTKK;TNQEIDQLRNASR;VRITRQLIER;YLIESVRQRDSK;YVASRDHYK 10 14.5 0.97843 -7.5708 14.5487 9.412 0 6.9751 6.60005 6.15139 0 8.81986 11.2947 7.28244 11.3926 0 Q8WXX0 DYH7_HUMAN Dynein axonemal heavy chain 7 (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2) DNAH7 KIAA0944 Homo sapiens (Human) cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; cytosol [GO:0005829]; inner dynein arm [GO:0036156]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AQILNGK;EKIEQYQEGLKLR;GINAGADILMFEGTELK;GLYKLEK;ILTWHLEICYK;KAQILNGK;KTDELPAHRAEMEILPKPWR;LAAAEGELK;LAESHPK;LDDLPAFK;LDLAADK;LNNSVFQWYGR;SAGAGAK;SHALLVGVGGSGRQSVTR;SLMFCDFHDPKREDTNYR 15 4 0.97825 -6.4852 12.5127 0 10.4522 8.41865 0 4.9471 11.6684 11.3736 0 10.2879 11.1314 7.33923 Q8WXX5 DNJC9_HUMAN DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73) DNAJC9 Homo sapiens (Human) nucleosome assembly [GO:0006334]; positive regulation of ATP-dependent activity [GO:0032781] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031] heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; protein-folding chaperone binding [GO:0051087] RAQEEAKEAEMSR 1 5 0.76692 0.058797 0 10.4593 0 0 0 0 0 0 0 7.62125 0 0 Q8WXX7 AUTS2_HUMAN Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; neuron migration [GO:0001764]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleus [GO:0005634] chromatin binding [GO:0003682] AAGEEAKQLAR;AHLNTEAREK;ENDRNLCQHLGKR;ISGLERSQEK;ISPTAGNQNGLLNK 5 4.6 0.97664 -2.1951 0 3.78125 10.4878 0 0 0 0 0 0 10.3659 8.86938 0 Q8WXX7 AUTS2_HUMAN Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; neuron migration [GO:0001764]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleus [GO:0005634] chromatin binding [GO:0003682] ENDRNLCQHLGKR;MCLGEEACLKSGNDMK 2 10.9 0.91543 -0.43101 0 0 0 0 6.36308 0 0 0 0 0 0 0 Q8WY21 SORC1_HUMAN VPS10 domain-containing receptor SorCS1 (hSorCS) SORCS1 SORCS Homo sapiens (Human) neuropeptide signaling pathway [GO:0007218]; post-Golgi vesicle-mediated transport [GO:0006892] Golgi apparatus [GO:0005794]; membrane [GO:0016020] neuropeptide receptor activity [GO:0008188] ARGTGASMAVAARSGR;IPGINVYAQMQNEK;IVTADGK;TVDGHSHYLTCR;VESQLIGK 5 4.8 0.9791 -1.9154 0 12.8447 0 0 0 0 0 11.2899 3.37504 4.42344 0 9.75059 Q8WY22 BRI3B_HUMAN BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1) BRI3BP KG19 Homo sapiens (Human) mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] AGLLLLLLLLLLLGLLAPGAQGAR;VLESLDR;YEGEPENAVLPLCFVVAVYFMTGPMGFYWR 3 24.3 0.22697 0.3031 0 0 4.68532 0 0 0 0 0 0 6.18996 0 0 Q8WY36 BBX_HUMAN HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) BBX HBP2 Homo sapiens (Human) bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GATKILADWWAVLDPK;GDWGIEKLGDTPR;GSILDAKPPK;TKPKEDCLLGSAK;WCPTTNKPVK 5 6.6 0.97479 -3.7443 0 0 0 7.78293 9.86504 9.80352 0 0 0 0 9.9714 11.2124 Q8WY36 BBX_HUMAN HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) BBX HBP2 Homo sapiens (Human) bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GATKILADWWAVLDPK;LSANISTK;WCPTTNKPVK 3 5.4 0.93754 -0.57623 0 0 13.0895 0 0 0 0 0 0 0 0 0 Q8WY41 NANO1_HUMAN Nanos homolog 1 (NOS-1) (EC_Rep1a) NANOS1 NOS1 Homo sapiens (Human) cell migration [GO:0016477]; cerebellar neuron development [GO:0098749]; epithelial cell migration [GO:0010631]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell growth [GO:0001558]; tissue homeostasis [GO:0001894] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270] FAELSPFAGR 1 3.4 0.8978 -0.23496 0 11.7427 0 0 0 0 0 0 0 0 0 0 Q8WY54 PPM1E_HUMAN Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) PPM1E CAMKN KIAA1072 POPX1 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] ENHGECK;FNPKFYSFLSAQEPSHK;VIFLHIISQRKR;VTDERFVQKAAR 4 9.3 0.9134 -0.3821 5.47884 0 5.84805 8.14175 0 0 10.4833 0 0 0 0 0 Q8WY64 MYLIP_HUMAN E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP) MYLIP BZF1 IDOL BM-023 PP5242 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] MENYGIEWHSVRDSEGQK 1 13.4 0.8257 -0.020415 0 0 0 0 7.18478 0 0 0 0 0 0 0 Q8WY91 THAP4_HUMAN Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) THAP4 CGI-36 PP238 Homo sapiens (Human) nitrate metabolic process [GO:0042126]; tyrosine metabolic process [GO:0006570] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213] DNWTPTK;GAAGWSPSSSGNPMAKPESR;RGAGGHGR;YSFLCSEHFTKDSFSKR 4 9 0.93713 -0.56761 0 0 5.93525 11.3099 5.36447 11.588 0 0 0 11.9726 12.0459 0 Q8WY98 TM234_HUMAN Transmembrane protein 234 TMEM234 C1orf91 PP1065 UNQ548/PRO1105 Homo sapiens (Human) membrane [GO:0016020] ALGEDIGGKR;LDYCECGTQLCGSR 2 13.3 0.91688 -0.41315 0 9.1727 0 0 0 0 0 0 0 0 0 5.33882 Q8WYA0 IFT81_HUMAN Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) IFT81 CDV1 Homo sapiens (Human) cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] tubulin binding [GO:0015631] NTAEQENLGKKLR 1 1.9 0.71234 0.14912 0 0 7.2555 0 0 0 0 0 0 0 0 0 Q8WYA0 IFT81_HUMAN Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) IFT81 CDV1 Homo sapiens (Human) cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] tubulin binding [GO:0015631] QDLTLSPRLECGGVIMAYCSLK 1 5.1 0.82985 -0.024722 0 5.7089 0 0 0 0 0 0 0 0 0 0 Q8WYA1 BMAL2_HUMAN Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9) BMAL2 ARNTL2 BHLHE6 CLIF MOP9 PASD9 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DTHTVNCRSMSNKELFPPSPSEMGELEATR;EAHSQTEK;RSFFCRIK 3 7.2 0.98024 -2.0072 0 0 0 0 0 0 10.6075 0 0 0 0 7.71459 Q8WYA6 CTBL1_HUMAN Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19) CTNNBL1 C20orf33 PP8304 Homo sapiens (Human) "adaptive immune response [GO:0002250]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445]" centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681] enzyme binding [GO:0019899] IEGEKHDMVR;LLQIIDR 2 3 0.9529 -0.7689 0 0 0 9.06606 8.48748 0 0 0 0 8.13206 0 0 Q8WYB5 KAT6B_HUMAN "Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)" KAT6B KIAA0383 MORF MOZ2 MYST4 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DQPRADPIPICSFCLGTKESNR;LLKDGPQYR;RKDLSVFEVDGNMSK;RPFVLKKK;SLQNYTR;TCSACRVQGR 6 3.4 0.97491 -4.0569 7.19052 0 0 0 0 0 0 12.1689 8.23711 0 0 9.86907 Q8WYH8 ING5_HUMAN Inhibitor of growth protein 5 (p28ING5) ING5 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; DNA replication-dependent chromatin disassembly [GO:0140889]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706] histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] IQNAYSKCK 1 3.8 0.90211 -0.26354 7.88069 0 0 0 0 0 10.9774 0 0 0 0 0 Q8WYJ6 SEPT1_HUMAN Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24) SEPTIN1 DIFF6 PNUTL3 SEPT1 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; meiotic metaphase chromosome alignment [GO:0051311]; protein localization [GO:0008104]; regulation of exocytosis [GO:0017157]; spindle assembly involved in female meiosis [GO:0007056] cell division site [GO:0032153]; centrosome [GO:0005813]; meiotic spindle [GO:0072687]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] QKIRDQLK;VNIIPVIGKADALMPQETQALK 2 8.1 0.96701 -1.3099 0 0 0 0 0 0 12.5827 0 13.0672 0 8.78663 0 Q8WYK0 ACO12_HUMAN Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15) ACOT12 CACH CACH1 STARD15 Homo sapiens (Human) acetyl-CoA metabolic process [GO:0006084]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] acetyl-CoA hydrolase activity [GO:0003986]; ATP binding [GO:0005524]; carboxylic ester hydrolase activity [GO:0052689]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] GAIARKR;VGQVITIKAKVTR 2 3.6 0.37643 0.2181 0 0 0 4.69583 0 0 0 0 0 0 0 9.39023 Q8WYK1 CNTP5_HUMAN Contactin-associated protein-like 5 (Cell recognition molecule Caspr5) CNTNAP5 CASPR5 Homo sapiens (Human) cell adhesion [GO:0007155] membrane [GO:0016020] EPLTNAVR;LIFIDNQPK;LSYNFSPEVEFR;VGKQVNFTVDK 4 3.1 0.98032 -1.7195 0 0 0 0 0 0 8.64429 0 5.74171 0 0 0 Q8WYK2 JDP2_HUMAN Jun dimerization protein 2 JDP2 Homo sapiens (Human) chromatin remodeling [GO:0006338]; fat cell differentiation [GO:0045444]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone chaperone activity [GO:0140713]; histone deacetylase binding [GO:0042826]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VAAARCRNK 1 5.5 0.97047 -1.344 0 0 0 0 10.4229 0 0 0 0 11.4657 0 0 Q8WYL5 SSH1_HUMAN Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) SSH1 KIAA1298 SSH1L Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of protein metabolic process [GO:0051246] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; synapse [GO:0045202] "actin binding [GO:0003779]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" KHTKELER;QMNCNLK;RADTSGPGAGAALEPPASLLEPSR;SRVPEKPASGPTEPPPFLPPAGSRR 4 6 0.97846 -2.0982 0 0 0 0 0 5.66536 0 0 11.4176 0 0 10.7828 Q8WYN3 CSRN3_HUMAN Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) CSRNP3 FAM130A2 TAIP2 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" EDCGCDCR;EDCGCDCRVFCDPDTCTCSLAGIK;LELEKNR 3 5.3 0.98075 -1.6168 0 0 9.4734 0 0 6.71781 0 0 0 6.82069 0 0 Q8WYP3 RIN2_HUMAN Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) RIN2 RASSF4 Homo sapiens (Human) endocytosis [GO:0006897]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] KRTSFQPVQVWR;LIAFYCISR 2 2.2 0.95266 -0.75061 10.9738 0 0 0 0 0 0 0 0 0 0 0 Q8WYP5 ELYS_HUMAN Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) AHCTF1 ELYS TMBS62 MSTP108 Homo sapiens (Human) cell division [GO:0051301]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465] chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] DEGGTGK;IEEPSPIVYSLPAPELPEAFFGTPISKASQKISR;LNIEELLK;LTKKTESQSQK;SILVPNEELSMVMSSKK;SVENQESVEIINDLKVSTVTSPSRMIR 6 4.6 0.97165 -1.352 0 0 0 8.42387 7.27566 0 12.399 0 7.34483 7.1418 0 6.77518 Q8WYQ5 DGCR8_HUMAN Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) DGCR8 C22orf12 DGCRK6 LP4941 Homo sapiens (Human) DNA damage response [GO:0006974]; positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]; regulation of stem cell proliferation [GO:0072091] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; site of double-strand break [GO:0035861] double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-RNA adaptor activity [GO:0140517] AKVEVCKDESVDLEEFR;HAPAVRKFSPDLK;LAEEREETR;MVKQETSDK 4 6.2 0.97212 -2.6938 0 0 9.56238 0 0 0 2.91936 11.1835 0 10.0941 10.1042 0 Q8WYQ9 ZCH14_HUMAN Zinc finger CCHC domain-containing protein 14 (BDG-29) ZCCHC14 KIAA0579 Homo sapiens (Human) nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] EESSDSAEENDR;YLASLPSHVLKNDHVR 2 3 0.81485 -0.0041332 0 0 0 0 0 8.4953 0 0 0 0 3.60573 0 Q8WYR1 PI3R5_HUMAN "Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K)" PIK3R5 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] "centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; G-protein beta/gamma-subunit complex binding [GO:0031683] ASGPGSK;ISGKVAR;LGIDGDREAVPLTLQIIYSK;QPGATTCTEDR;VCTSVNLNK 5 6.1 0.97609 -2.2649 0 0 8.85078 0 0 10.4442 0 12.0997 0 11.6526 0 0 Q8WZ04 TOMT_HUMAN Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2) TOMT COMT2 LRTOMT PP7517 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; methylation [GO:0032259]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] catechol O-methyltransferase activity [GO:0016206] LLVRTVLLRSLR;SLRDCLSGLR 2 6.5 0.98044 -1.6591 0 0 0 9.798 0 0 0 0 0 0 0 4.82146 Q8WZ33 MAFIP_HUMAN MaFF-interacting protein (Tektin-4 like protein PP5644) MAFIP MIP PP5644 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294] cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleolus [GO:0005730] LLQAEQSLRNLKDIHMSLEK 1 16.1 0.9651 -1.1219 0 0 0 0 0 0 0 0 0 0 0 13.6259 Q8WZ42 TITIN_HUMAN Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433] AADPIDPPGPPAKIR;ADLGDWHK;AEASTSYAELR;AGDNIKVEIPVLGRPKPTVTWK;AITQGGK;APKEEAAKPKGPIK;APPPPKVIKKPVIEK;APVAPPK;ATAVIKFCDR;ATKLIPNKEYIFR;CENVNKYDAGK;CEVSKDVPVK;CNEHLVPILTYTAK;CNFTDVSECQYTVTGLSPGDR;CSLTWSPPLQDGGSDISHYVVEKR;DADRLNSGCYELK;DAHRPGWLPVSESVTR;DELAPPTLHLDFR;DLEVSEIRK;DVLPGSAVCLK;DWLVKPIR;EAAMRAFK;EATRKSYAAVVTNCHK;EATRKSYSTATTK;EAVRADHGK;EDLQKPVLDLK;EEIVKKPPPPTTLIPAK;EEVVLKSVLRK;EFKPIEVLK;EKTVSDTNREQR;ELSATSSAQK;ENVEYHFR;EPAAFLK;EPGPPGTPFATAISK;EPVAIKK;ERNSILWQK;ERNSLLWVK;ESAVFTVELSHDNIRVKWFK;ESEFVRFSKTENK;ETPPVEEREIEK;ETTIRDTGEYTLELK;EVGVSITGTTVREER;EVNWYFENKLVPSDEKFK;EVTLDDISQIKAQVK;EVVLEKKVPLAPPK;EVYDYYCRR;FECVLTREANVIWSKGPDIIK;GDSCEVTGTIK;GEYVCDCGTDK;GTKLVVTGLKEGAFYK;HDGGSKIIGYFVEACK;HSEKWSECAR;IAFVEGTASLEIIR;IEAEPIQFTK;IEAHVYGKPHPTCKWK;IEEGKSLR;IEESERLK;IIGYHLEQKEK;ILARVKGRPEPDITWTK;IMTITRKK;IPHLQKGCEYVFRVR;IPVPVAK;ISCGGAIR;ISMDPKFR;ITGYIVERRDLPDGR;ITHEKVPEESEELR;ITIENVPK;ITWFANDREIKESSK;ITWSKDNK;IVGYSIEKRQGNER;IVLKPKIPAKIEEPPPAK;IVPEEKVREAVLK;KALAEEGKITIPTFKPDK;KAPAVVAKKPELPPVK;KAVAPPAKVPEVPK;KEEEVPPPPK;KERNTILWVK;KIVLKPKIPAK;KPVPEEKVAVPVPVAKK;KTVVPKVIVATPK;KVPLVVPK;KVPSTPPK;LAKVPEPPKK;LDIEDREIK;LEPSRIVK;LFAIVRGRPAPK;LGGPCPPHFLK;LIEGLVVKAGTTVRFPAIIR;LIKANLLANNEYYFR;LINGNEYQFR;LLEGNEYTFR;LLQNSENITIENTEHYTHLVMK;LLTSSQKHKFSFYNK;LNDYSIEK;LNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR;LSDHSVEPGK;LSFAVPQR;LSGVLTVK;LTEGNEYVFR;LTEHQEYKIR;LTGYVLEACK;LTIRVGEAFALTGR;LVEKTEYEFRVK;LVHVDKRPR;LVIRTTHFK;LVIVRAGCPIRLFAIVR;LVVTGLKEGAFYK;MLILKKALK;MPDDDGGDR;MPYDVPEPRKYK;MTLVENTATLTVLK;MVCSSVARTTFK;NASGSAK;NCQLKDQGNYRLVCGPHIASAK;NDTGKYILTIENGVGEPK;NSDIIVPHKYPK;NSILWQKVNTSPISGR;REQVQITQEKMR;SAALEEK;SAIPERRMK;SDIGQYTCDCGTDK;SESDGHK;SIVHEEITK;THIKTTPATLALEK;TPSPIEAERRK;TTIKITKLK;VAKLTIR;VAVPKKPEVPPAK;VCAENAAGPGK;VENDHGIAK;VEPANAGK;VGDEAWIK;VGDTLRLSAIIKGVPFPK;VIGLLRPLK;VIGYHLEYKER;VIILDKPGPPTGPIK;VIKKPVIEK;VIRTLKHR;VKELPLIFITPLSDVKVFEK;VKPRVIGLLRPLK;VKWLKDGK;VLDQNIPPSFTK;VLETGDR;VLVTQPQKTKPKLAK;VMDFVTDLEFTVPDLVQGKEYLFK;VNKDYVVYDTRLK;VNSRPIKDLK;VPAAPPK;VPEVPKKIVVEEK;VPEVPKKPVPEEKKPVPVPK;VPLVVPK;VPVLIPK;VPVTPPK;VSAENRAGIGPPSEASDSVLMK;VSIEAPK;VTAENPEGVIEHK;VTGHPKPIVKWYR;VTGLQEGSTYEFR;VTGLRDGQTYKFR;VTGYLIEMQK;VTNDNLLSR;VTWKKEDR;VVAKPKEMTPR;WFKDDVELVSGPK;WTKEGQDISK;WVACGEPVAETK;WYKDGRPLVASK;YILTLENSCGKK;YKQTTIEEDQR 169 5.5 0.97903 -67.836 12.9895 11.8841 13.1272 15.2406 19.5171 17.3707 14.8278 14.5311 14.4352 14.553 13.857 14.3555 Q8WZ42 TITIN_HUMAN Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433] ELQLSASTRIDEFK;ELSATSSAQK;EVGVSITGTTVREER;GSAYEIWR;GVLEKRPTRTSIVNPPQK;IDEFKTEQKEENMR;ITHEKVPEESEELR;KALAEEGKITIPTFKPDK;KTVVPKVIVATPK;LVHVDKRPR;NSDIIVPHKYPK;REQVQITQEKMR;SESDGHK;SLLEPDERIKMER;VTAENPEGVIEHK 15 3.3 0.97452 -3.1031 0 0 0 0 0 0 0 6.31927 0 9.81263 10.2674 0 Q8WZ59 TM190_HUMAN Transmembrane protein 190 TMEM190 MDAC1 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] inner acrosomal membrane [GO:0002079]; nucleus [GO:0005634] identical protein binding [GO:0042802] ESRDVEGGTEGEGTEEGEETEGEEEED 1 15.3 0.84017 -0.045996 0 0 0 0 0 0 0 0 0 4.31615 0 0 Q8WZ60 KLHL6_HUMAN Kelch-like protein 6 KLHL6 Homo sapiens (Human) B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to bacterium [GO:0009617] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] MVVLGGK;TGDLVEILNGEK 2 3.1 0.94597 -0.65593 9.5656 0 0 0 0 0 0 0 0 0 0 12.1471 Q8WZ64 ARAP2_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)" ARAP2 CENTD1 KIAA0580 Homo sapiens (Human) regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165] cytoplasm [GO:0005737] "GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" LSEKCDK;NIESARAELERLR;RILKQLQIILSK;SFSFTAETEKEK;SGWLDKLSPQGKR;SLGPKDSK;TLLASLTK 7 4.3 0.97334 -2.54 0 0 0 11.5892 0 0 0 7.57266 0 6.96255 0 5.91104 Q8WZ73 RFFL_HUMAN E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) RFFL RNF189 RNF34L Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of fibroblast migration [GO:0010762]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of TOR signaling [GO:0032006]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] EILARNFVNYKGCCEK;MNECPICR 2 6.6 0.88737 -0.19892 0 10.5166 0 0 0 0 0 0 0 9.56421 0 7.45664 Q8WZ74 CTTB2_HUMAN Cortactin-binding protein 2 (CortBP2) CTTNBP2 C7orf8 CORTBP2 KIAA1758 Homo sapiens (Human) regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synapse organization [GO:0050807] cell cortex [GO:0005938]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; glutamatergic synapse [GO:0098978]; postsynaptic actin cytoskeleton [GO:0098871]; synaptic vesicle [GO:0008021] SH3 domain binding [GO:0017124] HPSQGQQAVVKAALSILLNK;LAARLEEERGK;NCLEILCRHGGLEPERR;QVVLMLVK;SESDISKIADSR;VIIDSSR;VINEENLPK;VNTSPRRK 8 5.5 0.97519 -3.8881 4.84965 0 0 4.38391 0 0 0 0 0 11.2572 12.5097 0 Q8WZ75 ROBO4_HUMAN Roundabout homolog 4 (Magic roundabout) ROBO4 UNQ421/PRO3674 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; establishment of endothelial barrier [GO:0061028]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334] axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632]; signaling receptor activity [GO:0038023] LSLAPAEAWKAKK;VHLGPGLYR 2 2.2 0.92949 -0.46514 0 0 0 0 0 0 3.21397 0 0 0 0 12.724 Q8WZ82 OVCA2_HUMAN Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein) OVCA2 Homo sapiens (Human) response to retinoic acid [GO:0032526] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] hydrolase activity [GO:0016787] SDFGSCPPEEQPR 1 5.7 0.78748 0.017499 0 0 0 0 0 0 0 0 0 0 3.99467 0 Q8WZ92 OR5P2_HUMAN Olfactory receptor 5P2 (Olfactory receptor-like protein JCG3) OR5P2 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] STEGHHK;VILFMIILSGNLSIIILIR 2 8.1 0.88009 -0.15379 0 0 10.9932 0 0 5.75494 0 0 0 0 0 0 Q8WZA0 LZIC_HUMAN Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) LZIC Homo sapiens (Human) beta-catenin binding [GO:0008013] KQPGQLRTR 1 4.7 0.88335 -0.1723 0 0 0 0 0 0 5.17181 0 0 0 0 0 Q8WZA1 PMGT1_HUMAN "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2)" POMGNT1 MGAT1.2 UNQ746/PRO1475 Homo sapiens (Human) basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605] Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]" CLHIWDLDVRGNHR;GRECIIPDVSR;LTNQRALR 3 5 0.97842 -1.9796 0 0 0 0 6.44834 0 0 0 0 7.0258 0 8.25493 Q8WZA2 RPGF4_HUMAN Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 Homo sapiens (Human) adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-ion regulated exocytosis [GO:0017156]; G protein-coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; positive regulation of insulin secretion [GO:0032024]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle cycle [GO:0098693] cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] ASNQGNSQPQQK;DFKALWEK;FNEIQFWVVTEICLCSQLSK;HATIVTR;IAAHCKEYK;MRMIANTAR;QLNVIDNQR;SYVRQLNVIDNQRTLSQMSHR 8 8.5 0.97567 -4.4071 0 0 8.08576 0 9.28755 0 0 0 12.2946 0 0 12.0614 Q8WZA6 OR1E3_HUMAN Olfactory receptor 1E3 (Olfactory receptor 17-210) (OR17-210) (Olfactory receptor OR17-7) OR1E3 OR1E3P Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVIVGILPLLNLVGVVKLIMK 1 6.1 0.82645 -0.021489 0 0 0 5.16936 6.50174 0 5.6833 0 0 0 9.24079 5.61421 Q8WZA9 IRGQ_HUMAN Immunity-related GTPase family Q protein IRGQ IRGQ1 FKSG27 Homo sapiens (Human) GTP binding [GO:0005525] TDGEGEDPECLGEGK 1 2.4 0.64948 0.17064 0 0 6.29217 0 0 0 0 0 0 0 0 0 Q8WZB0 CI130_HUMAN Putative uncharacterized protein ERCC6L2-AS1 (ERCC6L2 antisense RNA 1) (Nasopharyngeal carcinoma-associated gene 12 protein) ERCC6L2-AS1 C9orf130 LINC00476 NAG12 Homo sapiens (Human) EGDVRSGGRAR;SNLPDVSSL 2 14.7 0.93024 -0.487 0 0 8.39326 0 0 10.7512 0 0 0 0 0 10.4266 Q92187 SIA8D_HUMAN "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)" ST8SIA4 PST PST1 SIAT8D Homo sapiens (Human) ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; sialylation [GO:0097503] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]; sialyltransferase activity [GO:0008373]" INSSLVLEIRKNILR 1 4.2 0.50749 0.18793 0 0 0 0 0 0 0 0 6.29212 0 0 0 Q92466 DDB2_HUMAN DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) DDB2 Homo sapiens (Human) cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; pyrimidine dimer repair [GO:0006290]; response to UV [GO:0009411]; UV-damage excision repair [GO:0070914] cell junction [GO:0030054]; chromatin [GO:0000785]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877] ELVSVPMEPGS 1 4.5 0.94142 -0.59811 0 0 9.18743 0 0 0 0 0 0 0 0 0 Q92478 CLC2B_HUMAN C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1) CLEC2B AICL CLECSF2 IFNRG1 Homo sapiens (Human) NK T cell activation [GO:0051132] external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018] CFIIVGVLITTNIITLIVK;MAKNRTGQWVDGATFTK 2 24.2 0.76478 0.065296 0 0 0 7.38448 0 0 0 0 10.29 0 0 0 Q92481 AP2B_HUMAN Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) TFAP2B Homo sapiens (Human) aorta morphogenesis [GO:0035909]; collecting duct development [GO:0072044]; distal tubule development [GO:0072017]; ductus arteriosus closure [GO:0097070]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; glucose metabolic process [GO:0006006]; hindlimb morphogenesis [GO:0035137]; kidney development [GO:0001822]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of insulin secretion [GO:0050796]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; skin development [GO:0043588]; smooth muscle tissue development [GO:0048745]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" VTVGEVQRR 1 2 0.78243 0.031766 0 0 0 0 0 0 0 0 0 0 0 11.2636 Q92482 AQP3_HUMAN Aquaporin-3 (AQP-3) (Aquaglyceroporin-3) AQP3 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; establishment of localization in cell [GO:0051649]; glycerol transmembrane transport [GO:0015793]; odontogenesis [GO:0042476]; positive regulation of immune system process [GO:0002684]; regulation of keratinocyte differentiation [GO:0045616]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; response to calcium ion [GO:0051592]; response to ischemia [GO:0002931]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; water transport [GO:0006833] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] glycerol channel activity [GO:0015254]; identical protein binding [GO:0042802]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] CGEMLHIRYR 1 3.6 0.88687 -0.19148 0 0 0 0 0 8.77017 0 0 0 0 0 0 Q92484 ASM3A_HUMAN "Cyclic GMP-AMP phosphodiesterase SMPDL3A (2',3'-cGAMP phosphodiesterase SMPDL3A) (EC 3.1.4.-) (Acid sphingomyelinase-like phosphodiesterase 3a) (ASM-like phosphodiesterase 3a) (EC 3.6.1.15)" SMPDL3A ASML3A Homo sapiens (Human) negative regulation of cGAS/STING signaling pathway [GO:0160049]; nucleoside triphosphate catabolic process [GO:0009143] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270] IISLNTNLYYGPNIMTLNK;KGSPVNSLFVAPAVTPVK 2 8.2 0.41259 0.20348 6.02072 0 0 0 0 0 0 0 0 8.48607 0 0 Q92485 ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B ASMLPD Homo sapiens (Human) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] "hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]" LIREVFPDTK 1 2.2 0.97507 -1.4391 0 0 0 0 0 0 0 0 0 9.80901 0 0 Q92499 DDX1_HUMAN ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) DDX1 Homo sapiens (Human) "defense response to virus [GO:0051607]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; nucleic acid metabolic process [GO:0090304]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; exonuclease activity [GO:0004527]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712] AAGGGSYK;DLGLAFEIPPHMK;FPPKDGFVALSKAPDGYIVK;TDDVHAK 4 6.5 0.9762 -1.4695 0 0 7.78378 0 0 0 9.55236 0 0 9.20609 0 9.21016 Q92502 STAR8_HUMAN StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) STARD8 DLC3 KIAA0189 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] focal adhesion [GO:0005925] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] KVKCFPLLQVK;LTAFMEK 2 1.6 0.93757 -0.54103 0 0 0 0 7.05658 0 0 0 0 0 0 0 Q92503 S14L1_HUMAN SEC14-like protein 1 SEC14L1 SEC14L Homo sapiens (Human) choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] protein sequestering activity [GO:0140311]; RIG-I binding [GO:0039552] LDVDAPR 1 1 0.90904 -0.30984 0 0 8.19288 0 0 0 0 0 0 0 0 0 Q92506 DHB8_HUMAN (3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) HSD17B8 FABGL HKE6 RING2 SDR30C1 Homo sapiens (Human) androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290] mitochondrial envelope [GO:0005740]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204]; plasma membrane [GO:0005886] (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0106386]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; NADH binding [GO:0070404]; testosterone dehydrogenase (NAD+) activity [GO:0047035] LLGGPGSK 1 3.1 0.91367 -0.39033 0 0 0 0 0 0 0 0 0 8.6946 0 0 Q92508 PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) PIEZO1 FAM38A KIAA0233 Homo sapiens (Human) cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane potential [GO:0042391] cuticular plate [GO:0032437]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261] DIPNAIR;EEEEGEEEK;EEQQEHQQQQQEEEEEEEDSR;FTWNFQR;RQHQLAPLPAQAVFASGTR;SPETMIK;TASELLLDRRLR 7 3.3 0.98075 -1.6307 0 0 0 0 0 6.83453 0 0 8.28137 6.86009 0 0 Q92520 FAM3C_HUMAN Protein FAM3C (Interleukin-like EMT inducer) FAM3C ILEI GS3786 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089] carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125] SPFEQHIKNNK;YEGWPEVVEMEGCIPQKQD 2 13.2 0.98081 -1.7784 0 11.9378 0 0 0 0 0 10.6604 0 0 5.98555 0 Q92521 PIGB_HUMAN GPI mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B) PIGB Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506]; mannosylation [GO:0097502] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "alpha-1,2-mannosyltransferase activity [GO:0000026]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]" ILLVTVLWTLLVYSMLSHK 1 3.4 0.78199 0.022047 0 0 0 0 0 0 0 0 0 4.96869 0 0 Q92522 H1X_HUMAN Histone H1.10 (Histone H1x) H1-10 H1FX Homo sapiens (Human) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] cadherin binding [GO:0045296]; double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] AGGSAALSPSK;KVPWFDQQNGRTYLK;LEGGGERR;RADKKPAR;SVELEEALPVTTAEGMAK;TAAAGGK 6 31.5 0 4.2671 0 9.27887 9.11751 0 9.46244 7.18339 0 0 8.4266 7.7385 11.0802 0 Q92523 CPT1B_HUMAN "Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein)" CPT1B KIAA1670 Homo sapiens (Human) carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid transport [GO:0015909]; response to blue light [GO:0009637] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] carnitine O-palmitoyltransferase activity [GO:0004095] ALLHGNCYNR;ALLSMAIFSTGVWVTGIFFFRQTLK;LQWDIPK 3 5.4 0.9668 -1.2937 0 0 0 0 10.9312 0 0 0 0 8.76298 0 0 Q92526 TCPW_HUMAN T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) CCT6B Homo sapiens (Human) protein folding [GO:0006457] chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] GIDPFSLDSLAK;IIDLKDKVCAQSNK 2 4.9 0.93721 -0.567 11.6544 0 0 0 0 0 0 0 0 0 0 0 Q92529 SHC3_HUMAN SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) SHC3 NSHC SHCC Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971] LSSSGLR 1 1.2 0.93682 -0.54466 0 0 0 7.89433 0 0 0 0 0 0 0 0 Q92529 SHC3_HUMAN SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) SHC3 NSHC SHCC Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971] LLIRLTIGLERPPGQVVVK;LTIGLERPPGQVVVK 2 4 0.7127 0.1474 0 0 6.61606 4.55649 0 0 14.3192 0 0 0 0 0 Q92530 PSMF1_HUMAN Proteasome inhibitor PI31 subunit (hPI31) PSMF1 Homo sapiens (Human) negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839] endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] DLYVLRYEYK 1 3.7 0.92673 -0.45407 0 0 0 0 3.45115 0 0 0 0 0 0 0 Q92535 PIGC_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C) PIGC GPI2 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] catalytic activity [GO:0003824] MYAQPVTNTKEVK;YAQPVTNTKEVK 2 4.4 0.95402 -0.89094 0 0 0 0 0 0 0 4.36933 0 0 7.71877 0 Q92538 GBF1_HUMAN Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) "cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; cilium assembly [GO:0060271]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; membrane [GO:0016020]; peroxisome [GO:0005777]; trans-Golgi network [GO:0005802] "guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" AGGMSDSSKWK;FTQSSQK;GPSTENQEAK;IDCFLPHLRDELFK;IVLENRDR;KQNAPMTLEEFRK;SAEHTLVDMVQLLFTRLPQFK 7 4.5 0.97829 -6.3376 0 0 11.5554 0 11.1394 7.70522 0 0 0 0 0 8.60851 Q92539 LPIN2_HUMAN Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) LPIN2 KIAA0249 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; lipid metabolic process [GO:0006629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] FKIECLNDIK;GYLHWVNDK;IECLNDIK;LGVLRSKEK;NLFAPSK 5 3.9 0.97901 -2.0473 0 5.88431 3.54251 0 0 7.626 0 9.57839 0 0 0 0 Q92540 SMG7_HUMAN Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) SMG7 C1orf16 EST1C KIAA0250 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] AARTCAHQAQKK;ADMTDSKLGPAEVWTSR;NRANPNR 3 3.1 0.97845 -2.1268 0 0 9.02763 0 0 0 0 8.42004 0 0 8.70151 0 Q92540 SMG7_HUMAN Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) SMG7 C1orf16 EST1C KIAA0250 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] LVTDLEYALDK;NRANPNR 2 1.6 0.79477 0.015769 0 0 0 0 0 0 0 0 0 8.64605 0 0 Q92541 RTF1_HUMAN RNA polymerase-associated protein RTF1 homolog RTF1 KIAA0252 Homo sapiens (Human) blastocyst growth [GO:0001832]; chromatin organization [GO:0006325]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] KQEEEQEK;LEFVSNQEFTESEFMK;LEQMTEKER;TVTGCFVR;VAEITGVVETAK;WKEAMFSAGMQLPTLDEINKK 6 10.4 0.94481 -0.64469 9.41747 0 11.2563 4.00144 0 10.4244 0 0 9.031 0 0 0 Q92542 NICA_HUMAN Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Homo sapiens (Human) adult behavior [GO:0030534]; amyloid precursor protein biosynthetic process [GO:0042983]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; cellular response to calcium ion [GO:0071277]; central nervous system myelination [GO:0022010]; cerebellum development [GO:0021549]; epithelial cell proliferation [GO:0050673]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; glutamate receptor signaling pathway [GO:0007215]; learning or memory [GO:0007611]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; neuron apoptotic process [GO:0051402]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of long-term synaptic potentiation [GO:1900271]; short-term synaptic potentiation [GO:1990926]; T cell proliferation [GO:0042098] azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; ATPase binding [GO:0051117]; growth factor receptor binding [GO:0070851]; protein-macromolecule adaptor activity [GO:0030674]" ALADVATVLGR;FLRARNISGVVLADHSGAFHNK;LLSFCVLLAGLCR 3 6.5 0.75193 0.079697 8.97785 0 0 0 0 0 0 0 0 9.63787 0 0 Q92544 TM9S4_HUMAN Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1) TM9SF4 KIAA0255 TUCAP1 Homo sapiens (Human) cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] IVNTPFQVLMNSEK;TLKGHRWK 2 3.4 0.98061 -1.6658 0 0 0 0 0 0 10.6281 0 0 0 0 0 Q92545 TM131_HUMAN Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) collagen biosynthetic process [GO:0032964] membrane [GO:0016020] collagen binding [GO:0005518] AVIAVGSLTCFPK;ITAELSWPSILSSPR 2 1.5 0.013752 0.78076 0 0 10.0635 0 0 0 12.5986 3.86027 3.24208 0 0 12.8251 Q92546 RGP1_HUMAN RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog) RGP1 KIAA0258 Homo sapiens (Human) "negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] SLHLYNISDGRGK 1 3.3 0.95355 -0.67593 0 0 0 0 0 0 0 0 0 0 0 11.4066 Q92547 TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) TOPBP1 KIAA0259 Homo sapiens (Human) broken chromosome clustering [GO:0141112]; chromosome organization [GO:0051276]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein localization to site of double-strand break [GO:1990166]; response to ionizing radiation [GO:0010212] actin cytoskeleton [GO:0015629]; BRCA1-B complex [GO:0070532]; centrosome [GO:0005813]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; spindle pole [GO:0000922] chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539] GQKYECAK;SRVLEALR;VVVCVSKK 3 1.6 0.98083 -1.7417 12.5754 0 8.61747 0 0 0 0 0 0 0 0 0 Q92551 IP6K1_HUMAN Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) IP6K1 IHPK1 KIAA0263 Homo sapiens (Human) inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; diphosphoinositol tetrakisphosphate kinase activity [GO:0052839]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" YYGRGLSIEGFR 1 2.7 0.88898 -0.18696 0 0 0 9.05075 8.9892 0 0 0 0 0 0 0 Q92552 RT27_HUMAN "Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27)" MRPS27 KIAA0264 Homo sapiens (Human) cell population proliferation [GO:0008283]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] mitochondrial ribosome binding [GO:0097177]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] NWTIHTWIR 1 2.2 0.93713 -0.53958 0 0 0 0 9.91804 0 0 0 0 0 0 0 Q92556 ELMO1_HUMAN Engulfment and cell motility protein 1 (Protein ced-12 homolog) ELMO1 KIAA0281 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis, engulfment [GO:0006911]; Rac protein signal transduction [GO:0016601]; regulation of postsynapse assembly [GO:0150052]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] SH3 domain binding [GO:0017124] LNRLVEGTCFR;SIILTHVIR 2 2.8 0.97634 -2.2915 0 0 0 0 0 0 0 0 0 0 11.696 0 Q92558 WASF1_HUMAN Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) WASF1 KIAA0269 SCAR1 WAVE1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; lamellipodium morphogenesis [GO:0072673]; mitochondrion organization [GO:0007005]; modification of postsynaptic actin cytoskeleton [GO:0098885]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898] actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; SCAR complex [GO:0031209] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237] FYTNPSYFFDLWKEK 1 2.7 0.91503 -0.43428 0 0 0 0 0 0 0 0 0 7.81256 0 0 Q92562 FIG4_HUMAN "Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16)" FIG4 KIAA0274 SAC3 Homo sapiens (Human) locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; pigmentation [GO:0043473]; positive regulation of neuron projection development [GO:0010976]; vacuole organization [GO:0007033] early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; recycling endosome [GO:0055037] "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein serine/threonine phosphatase activity [GO:0004722]" GSSGLFR;SYTYWWTPEVIK;VTENVVQPMK;YFLVGSNNAETK 4 4.5 0.95275 -0.75806 0 0 0 0 11.6796 0 10.0003 0 0 8.46536 0 12.3525 Q92563 TICN2_HUMAN "Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2)" SPOCK2 KIAA0275 TICN2 UNQ269/PRO306 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; extracellular matrix organization [GO:0030198]; negative regulation of endopeptidase activity [GO:0010951]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of cell differentiation [GO:0045595]; synapse assembly [GO:0007416] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191] LEQQACLSSK;SLGASCK 2 4 0.93682 -0.54435 0 0 0 0 0 0 0 11.4075 0 0 9.94325 0 Q92564 DCNL4_HUMAN DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) DCUN1D4 KIAA0276 Homo sapiens (Human) positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116] nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182] IYHTLNKLNLTEDIGQDDHQTGSLR;VINKDQWCNVLEFSR;YAFDFARQSK 3 19.5 0.95569 -0.98867 0 0 0 0 0 10.1084 8.72523 0 0 0 0 0 Q92565 RPGF5_HUMAN Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) RAPGEF5 GFR KIAA0277 MRGEF Homo sapiens (Human) nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]; small GTPase-mediated signal transduction [GO:0007264] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085] FKKLFSELESLTDPSLNHK;HTVDEYSPQK;IAAHCKAQR;IQYAEEDLALVAITFSGEK;LRVFDPHLER;TFLDNLVNFEK;VLHLVSQWIALYKDWLPEDEHSKMFLK 7 18.1 0.97493 -3.1868 9.06482 0 0 10.2201 0 0 9.40075 12.6817 0 8.20604 11.021 0 Q92567 F168A_HUMAN Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1) FAM168A KIAA0280 TCRP1 Homo sapiens (Human) positive regulation of base-excision repair [GO:1905053] TYQASSAAFR 1 4.1 0.93411 -0.50426 0 0 0 0 0 0 0 0 0 0 8.198 0 Q92569 P55G_HUMAN Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) PIK3R3 Homo sapiens (Human) B cell differentiation [GO:0030183]; cell migration involved in sprouting angiogenesis [GO:0002042]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; negative regulation of anoikis [GO:2000811]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; T cell differentiation [GO:0030217] "cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphotyrosine residue binding [GO:0001784] IMMNYDKLK;LGEIHDSKMR 2 4.1 0.98059 -1.6151 0 0 0 0 0 0 0 0 0 0 6.96405 0 Q92570 NR4A3_HUMAN Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) NR4A3 CHN CSMF MINOR NOR1 TEC Homo sapiens (Human) animal organ regeneration [GO:0031100]; cellular respiration [GO:0045333]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to leptin stimulus [GO:0044320]; common myeloid progenitor cell proliferation [GO:0035726]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gastrulation [GO:0007369]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of feeding behavior [GO:2000253]; positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway [GO:0038097]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "cAMP response element binding [GO:0035497]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ITSSLKDHQSK;LSIRSNTAEDK 2 3.5 0.98087 -1.7315 0 0 0 0 0 10.4085 0 0 0 0 0 10.3647 Q92572 AP3S1_HUMAN "AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)" AP3S1 CLAPS3 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; insulin receptor signaling pathway [GO:0008286]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; AP-type membrane coat adaptor complex [GO:0030119]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; presynapse [GO:0098793]; transport vesicle [GO:0030133] NMNLPEIPR 1 4.7 0.88353 -0.1722 0 0 0 0 0 0 0 11.6192 0 0 0 0 Q92574 TSC1_HUMAN Hamartin (Tuberous sclerosis 1 protein) TSC1 KIAA0243 TSC Homo sapiens (Human) activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cardiac muscle cell differentiation [GO:0055007]; cell population proliferation [GO:0008283]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to starvation [GO:0009267]; cerebral cortex development [GO:0021987]; D-glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of stress fiber assembly [GO:0051492]; response to insulin [GO:0032868]; synapse organization [GO:0050808] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596] ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087] AGPFSSR;DLGVEAK;EQARYNQLQEQR;EVEMMKAAYR;ILELESHLAKKDHLLLEQK;ITQVFELEILDLYGRLEK;LDCCNDGCSDSMVGHNEEASGHNGETK;LEEEKAEAAEAAEER;SFLGMKAR 9 10.6 0.97489 -3.5498 0 0 10.5506 0 0 0 0 0 10.5158 11.257 10.3605 8.43792 Q92575 UBXN4_HUMAN UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) UBXN4 KIAA0242 UBXD2 UBXDC1 Homo sapiens (Human) ERAD pathway [GO:0036503]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] KQEEELTKR;LEERREEK;TQDDGEDENNTWNGNSTQQM 3 7.3 0.96563 -1.1332 8.41177 0 0 0 0 0 0 0 6.18434 9.80371 0 0 Q92576 PHF3_HUMAN PHD finger protein 3 PHF3 KIAA0244 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872] EEVCMSLKPEYHKENR;ELAAWRR;HSLKDILMK;LSHGDRGTDGK;YEVIHSKTK;YIGPQNFYQVK 6 3.1 0.96162 -1.0674 0 13.7335 0 0 8.6249 0 10.2256 0 0 0 0 0 Q92583 CCL17_HUMAN C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine) CCL17 SCYA17 TARC Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; signaling receptor binding [GO:0005102] TWYQTSEDCSR 1 11.7 0.80836 0.0088873 0 0 0 0 0 0 0 0 0 6.32979 0 0 Q92585 MAML1_HUMAN Mastermind-like protein 1 (Mam-1) MAML1 KIAA0200 Homo sapiens (Human) atrioventricular node cell development [GO:0060928]; atrioventricular node development [GO:0003162]; myoblast differentiation [GO:0045445]; Notch signaling pathway [GO:0007219]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; protein phosphorylation [GO:0006468] MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peptide antigen binding [GO:0042605]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] IELCRRHHSTCEAR;LELERQHTFALHQRCIQAK;QPPAATAPAPAAPAPR 3 4.8 0.98083 -1.6311 0 0 0 0 0 0 0 10.8122 0 7.65206 0 0 Q92597 NDRG1_HUMAN Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) NDRG1 CAP43 DRG1 RTP Homo sapiens (Human) "cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; mast cell activation [GO:0045576]; negative regulation of cell population proliferation [GO:0008285]; peripheral nervous system myelin maintenance [GO:0032287]; response to metal ion [GO:0010038]; signal transduction [GO:0007165]" adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] cadherin binding [GO:0045296]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] TASGSSVTSLDGTR 1 3.6 0 3.2712 0 0 0 0 0 0 0 0 0 10.7323 10.6951 0 Q92598 HS105_HUMAN Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) HSPH1 HSP105 HSP110 KIAA0201 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of NK T cell activation [GO:0051135]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] adenyl-nucleotide exchange factor activity [GO:0000774]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] AFNDPFIQK;ALLRLYQECEK;ATAAVLR;IAKFFGK;IGTPVKVRFQEAEERPK;LEELMKIGTPVK;LVEHFCAEFK;SLDQDPVVR;TPNGPNIDK;VLGTAFDPFLGGK 10 11.4 0.98084 -1.744 8.73291 11.9402 10.9677 8.16591 7.80271 8.95076 0 11.4195 12.5981 9.96967 10.4703 8.55248 Q92599 SEPT8_HUMAN Septin-8 SEPTIN8 KIAA0202 SEPT8 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; regulation of intracellular protein transport [GO:0033157]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542] axon [GO:0030424]; cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynapse [GO:0098793]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ARQYPWGVVQVENENHCDFVK;EMLIRVNMEDLREQTHSR;ETELELK;KLDSKVNIIPIIAK;RVHQEEKR 5 14.1 0.97494 -3.4551 5.19995 0 0 0 0 0 0 0 0 0 10.2277 0 Q92604 LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) LPGAT1 FAM34A KIAA0205 Homo sapiens (Human) phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]; positive regulation of fatty acid biosynthetic process [GO:0045723]; triglyceride biosynthetic process [GO:0019432] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; 2-acylglycerophosphocholine O-acyltransferase activity [GO:0047190]; acyltransferase activity [GO:0016746]; lysophosphatidylethanolamine acyltransferase activity [GO:0071618]; lysophospholipid acyltransferase activity [GO:0071617] DVPLETDDLTTWLYQR;IFPIKDVPLETDDLTTWLYQRFVEK 2 6.8 0.75053 0.078619 6.38147 0 0 0 8.3319 0 0 10.4915 8.1091 0 0 0 Q92608 DOCK2_HUMAN Dedicator of cytokinesis protein 2 DOCK2 KIAA0209 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; alpha-beta T cell proliferation [GO:0046633]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; establishment of T cell polarity [GO:0001768]; immunological synapse formation [GO:0001771]; macropinocytosis [GO:0044351]; membrane raft polarization [GO:0001766]; myeloid dendritic cell activation involved in immune response [GO:0002277]; myoblast fusion [GO:0007520]; negative thymic T cell selection [GO:0045060]; positive regulation of phagocytosis [GO:0050766]; positive thymic T cell selection [GO:0045059]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; T cell receptor binding [GO:0042608] ALEYVFKFIVRSR;EYERREDFQMQLMTQFPNAEK;FHYSRPVRR;MLVGDIIQIRKDYPHLVDR;QLKETLYETIIGYFDKGK;SVVYYQVKQPR;TVITMGR;VVFTDLGNKDLNR 8 6.1 0.9716 -1.3547 9.75292 0 11.3457 11.4573 8.12138 0 0 0 0 0 0 11.2093 Q92609 TBCD5_HUMAN TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) "autophagy [GO:0006914]; macroautophagy [GO:0016236]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; retromer complex [GO:0030904] AP-2 adaptor complex binding [GO:0035612]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; retromer complex binding [GO:1905394] DSFFSNISRSRSHSK;ILTDVLFCYAR;RNPRPVTYQFHPNLDYYKAR 3 5.8 0.71291 0.14638 0 0 10.6863 0 0 0 9.44014 11.3426 0 0 0 0 Q92610 ZN592_HUMAN Zinc finger protein 592 ZNF592 KIAA0211 Homo sapiens (Human) negative regulation of insulin receptor signaling pathway [GO:0046627] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; PH domain binding [GO:0042731] TLKRYPCR;TLLFFNKCSLLR;TSSGEIK 3 2.1 0.98031 -1.6823 0 0 6.52096 0 0 0 0 0 0 0 0 0 Q92613 JADE3_HUMAN Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) JADE3 KIAA0215 PHF16 Homo sapiens (Human) regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] EESIHTR;ENPPHDSR;LLASLSHSR;WALVCNLCK 4 4 0.97839 -2.0983 0 0 0 0 0 0 10.8605 0 0 9.0625 0 0 Q92614 MY18A_HUMAN Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) MYO18A CD245 KIAA0216 MYSPDZ TIAF1 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030] actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; trans-Golgi network [GO:0005802] "actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]" AAQQFSK;ELETRLEFER;GFFNLNRSSK;GLLWLLEEEALVPGASEDTLLER;GSVLQRAAK;GYLARQHFK;LEFERTQVK;LESLASR;LEVEQQNK;LFSYYGPQEGDKK;LLQDSQK;LLQDSQKK;MSAAELRSLEEMSLRR;QLRDTKEEMGELAR 14 6.7 0.97828 -8.5261 0 0 12.3354 9.31746 8.35328 9.94009 0 0 11.1359 7.40463 10.0309 9.60639 Q92614 MY18A_HUMAN Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) MYO18A CD245 KIAA0216 MYSPDZ TIAF1 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030] actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; trans-Golgi network [GO:0005802] "actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]" AAQQFSK;ELETRLEFER;GLLWLLEEEALVPGASEDTLLER;GYLARQHFK;LEFERTQVK;LESLASR;LEVEQQNK;LFSYYGPQEGDKK;LLQDSQK;LLQDSQKK;MHMFKGCRR;QLRDTKEEMGELAR 12 7.1 0.82583 -0.020734 10.0585 0 0 0 0 0 0 0 0 0 0 0 Q92615 LAR4B_HUMAN La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) LARP4B KIAA0217 LARP5 Homo sapiens (Human) positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730] mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] SVQVNGAATELR 1 1.6 0.80662 0.012281 0 0 0 0 0 0 0 0 4.65798 0 0 0 Q92616 GCN1_HUMAN Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) GCN1 GCN1L1 KIAA0219 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; ribosome [GO:0005840] "cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]; ubiquitin-protein transferase regulator activity [GO:0055106]" ALADENEFVR;ASLLDPVPEVR;CLQNPSSDIR;EAADDCAK;IDPEAFITR;IVVSNTPR;LIGNESKGEHVPGFCLPKK;LTEWFKK;QAGAEALSQAVAR;QASLHVWKIVVSNTPRTLR;VISESPPDQWEAR;VLPLEALVTDAGEVTEAGK;VVLPYLVPK;YLLDSCAPLLRYLSHSEFK 14 6.2 0.0088889 1.1348 9.14665 0 0 0 4.91586 0 11.5238 12.3833 9.63447 9.70957 5.01328 12.4771 Q92618 ZN516_HUMAN Zinc finger protein 516 ZNF516 KIAA0222 Homo sapiens (Human) adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; response to cold [GO:0009409] nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATCHTCCICGK;GSEVHTTSADAPK;SAARPNR;SGSSPLGVVTKAASMPKNK;SNLVFLSRSGR 5 5.2 0.98005 -2.0105 0 0 0 0 0 0 0 10.0069 0 4.2916 9.09476 0 Q92619 HMHA1_HUMAN Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] ARHGAP45 HMHA1 KIAA0223 Homo sapiens (Human) negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AEAEAKAASR;AFHYESNNDLEK;DLPPENRASLQYLLRHLR;GLLGWVCTWTWAWR;TCVADAKTQKQELEDTK;TTLEMEFAKGLQKIAHNCR 6 7.8 0.94504 -0.64984 0 0 0 0 10.4782 8.81048 8.41257 0 9.03971 0 0 4.67751 Q92620 PRP16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) DHX38 DDX38 KIAA0224 PRP16 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] CICAAYFHQAAK;DSERSHR;EVVARRSDLK;HRPKDAATPSR;IVFTKQPEPVIPVKDATSDLAIIAR;KGSQTVR 6 5.9 0.90946 -0.31066 0 0 0 0 10.6954 5.40453 0 10.2129 0 8.38776 0 8.4192 Q92621 NU205_HUMAN Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) NUP205 C7orf14 KIAA0225 Homo sapiens (Human) mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] GITQKEQDGLIAFLQLTSTIITWSENAR;GLVAVLLYWDGK;ILKKHKPDFISLFK;LLPEQLIK;LQDSQLWK;TGPVAVR;YLYHGNTNPELAFESAK 7 4.7 0.96446 -1.1736 8.44012 8.64713 0 8.53278 0 0 9.86615 0 9.45018 8.33204 8.69502 0 Q92622 RUBIC_HUMAN Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) RUBCN KIAA0226 Homo sapiens (Human) autophagy [GO:0006914]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; phagocytosis [GO:0006909] cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol phosphate binding [GO:1901981] GAPGGPR;LLAQIDASMFAR;NMFKTCRLAK;VQLCHMK 4 3.9 0.94476 -0.63945 0 8.90686 10.9473 0 0 0 0 0 0 0 11.8916 7.11738 Q92623 TTC9A_HUMAN Tetratricopeptide repeat protein 9A (TPR repeat protein 9A) TTC9 KIAA0227 TTC9A Homo sapiens (Human) bone development [GO:0060348] GSAAGAK 1 3.2 0.64028 0.173 0 0 0 0 0 0 0 0 0 0 12.1974 10.1085 Q92624 APBP2_HUMAN Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) APPBP2 KIAA0228 PAT1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule motor activity [GO:0003777]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] CSYIAESDAAVKEK;LAQTYMDK 2 3.8 0.9571 -1.0218 0 0 0 0 0 0 0 0 0 0 0 9.2943 Q92626 PXDN_HUMAN Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] PXDN KIAA0230 MG50 PRG2 PXD01 VPO VPO1 Homo sapiens (Human) angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979] basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] "extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; interleukin-1 receptor antagonist activity [GO:0005152]; lactoperoxidase activity [GO:0140825]; laminin-1 binding [GO:0043237]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]" LRNLNTLLLNNNQIKR;SLEFSYQEDKPTK;THLFDSRPRSPNDLLALFR;VWQDCCEDCR 4 3.9 0.056314 0.4551 0 7.90791 7.94046 3.96023 2.9692 0 0 0 0 0 0 10.3828 Q92628 K0232_HUMAN Uncharacterized protein KIAA0232 KIAA0232 Homo sapiens (Human) ATP binding [GO:0005524] QEEKIHK;TSKLESVCGIQLEQK 2 1.6 0.95114 -0.69622 0 0 0 0 0 0 0 0 12.8701 0 0 0 Q92629 SGCD_HUMAN Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) SGCD Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; cardiac muscle tissue development [GO:0048738]; coronary vasculature morphogenesis [GO:0060977]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]; protein-containing complex localization [GO:0031503] cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] LESKDGEVR;SIETPNVRADPFKELR 2 9.8 0.9112 -0.3267 0 0 4.39197 0 8.90038 0 0 5.11216 0 0 0 0 Q92630 DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] APEVILGAR;SMEGMGK 2 2.7 0.8805 -0.1499 0 0 7.18428 0 0 0 0 0 0 0 6.93782 0 Q92636 FAN_HUMAN Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation) NSMAF FAN Homo sapiens (Human) ceramide metabolic process [GO:0006672]; positive regulation of amide metabolic process [GO:0034250]; positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid metabolic process [GO:0045834]; regulation of membrane lipid metabolic process [GO:1905038]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] sphingomyelin phosphodiesterase activator activity [GO:0016230] KQQEQQLQLYSK 1 1.3 0.67487 0.1671 0 0 0 0 0 6.2804 0 0 0 0 0 0 Q92636 FAN_HUMAN Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation) NSMAF FAN Homo sapiens (Human) ceramide metabolic process [GO:0006672]; positive regulation of amide metabolic process [GO:0034250]; positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid metabolic process [GO:0045834]; regulation of membrane lipid metabolic process [GO:1905038]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] sphingomyelin phosphodiesterase activator activity [GO:0016230] AAHPEGR 1 0.7 0.9097 -0.3178 6.85237 7.17822 0 0 0 0 0 0 0 0 0 0 Q92637 FCGRB_HUMAN Putative high affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc gamma receptor IB pseudogene) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB) FCGR1BP FCGR1B IGFRB Homo sapiens (Human) antibody-dependent cellular cytotoxicity [GO:0001788]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] IgG binding [GO:0019864]; IgG receptor activity [GO:0019770]; immunoglobulin receptor activity [GO:0019763] LVYNVLYYRNGK 1 4.3 0.95199 -0.67059 0 0 13.126 0 0 0 0 0 0 0 0 0 Q92643 GPI8_HUMAN GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) PIGK GPI8 Homo sapiens (Human) attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; proteolysis [GO:0006508] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020] GPI-anchor transamidase activity [GO:0003923]; protein disulfide isomerase activity [GO:0003756] SLCVSTPGHR 1 2.5 0.89601 -0.23676 0 0 6.73363 0 0 0 0 0 8.62238 0 0 0 Q92664 TF3A_HUMAN Transcription factor IIIA (TFIIIA) GTF3A Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383] nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5S rRNA binding [GO:0008097]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] FNTKSNLK;HFASPSK;HFERKHENQQK 3 7.1 0.9419 -0.59608 0 8.98376 0 0 8.49394 0 0 0 0 7.39772 0 0 Q92665 RT31_HUMAN "Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38)" MRPS31 IMOGN38 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ETSESQDSEKENTKK 1 3.8 0.75288 0.07703 0 0 0 0 0 0 0 0 0 0 6.93605 0 Q92667 AKAP1_HUMAN "A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)" AKAP1 AKAP149 PRKA1 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723] ELSTVSK;ELSTVSKLPAEPPALLQTHPPCRR;KVQPGYPVVPAEK;VQPGYPVVPAEKRSSGER 4 4.8 0.97242 -2.7836 14.5487 0 3.06357 8.16063 0 12.7071 0 0 0 10.1365 0 0 Q92670 ZN75C_HUMAN Putative zinc finger protein 75C (Zinc finger protein 75C pseudogene) ZNF75CP ZNF75C Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QLSLLRHQK 1 2.1 0.97955 -1.5476 0 0 0 0 0 0 0 0 10.2853 0 0 0 Q92673 SORL_HUMAN Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) adaptive thermogenesis [GO:1990845]; cell migration [GO:0016477]; diet induced thermogenesis [GO:0002024]; endosome to plasma membrane protein transport [GO:0099638]; insulin receptor recycling [GO:0038020]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of triglyceride catabolic process [GO:0010897]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to Golgi apparatus [GO:0034067]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910] cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuronal cell body [GO:0043025]; nuclear envelope lumen [GO:0005641]; perinucleolar compartment [GO:0097356]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658] amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; neuropeptide binding [GO:0042923]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888] CDGFLDCSDESDEK;CDGHQDCQDGR;CDLEDDCGDNSDESHCEMHQCR;ENDCGDWSDEK;GKNTGSNACVPRPCSLLCLPKANNSR;LEPGGKYHIIVQLGNMSK;MIPDSRLPPRHLHVVHTGK;QLWKSDDFGQTWIMIQEHVK;SDEYNCSSGMCIRSSWVCDGDNDCR;VGNLTAHTSYEISAWAK;VNGYVVNLFWAFDTHKQER;VQVQCLSK;WACDGDTDCQDGSDEDPVNCEK;WACDGDTDCQDGSDEDPVNCEKK 14 10.5 0.97329 -2.8932 2.04618 0 8.70186 0 6.6737 8.0427 9.82477 5.12499 5.0185 9.50993 8.49129 10.5933 Q92674 CENPI_HUMAN Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) CENPI FSHPRH1 ICEN19 LRPR1 Homo sapiens (Human) CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; mitotic sister chromatid segregation [GO:0000070]; sex differentiation [GO:0007548] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NLTAAKK;TGVAEYK 2 1.9 0.91075 -0.28723 0 0 11.0515 0 0 0 0 0 7.46597 0 8.14461 0 Q92685 ALG3_HUMAN "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)" ALG3 NOT NOT56L Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553] "alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]" STQHSKK 1 1.6 0.88066 -0.14964 10.1186 9.8351 7.94251 4.48085 0 0 8.64407 0 0 10.0261 10.3283 0 Q92688 AN32B_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) ANP32B APRIL PHAPI2 Homo sapiens (Human) inner ear development [GO:0048839]; negative regulation of cell differentiation [GO:0045596]; nucleosome assembly [GO:0006334]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein export from nucleus [GO:0046827]; regulation of apoptotic process [GO:0042981]; roof of mouth development [GO:0060021]; vasculature development [GO:0001944]; ventricular system development [GO:0021591] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; RNA polymerase binding [GO:0070063] ETDDEGEDD;IFGGLDMLAEK;RETDDEGEDD 3 8.4 0.9584 -1.0108 0 0 0 0 0 4.33242 0 0 0 0 3.00836 0 Q92692 NECT2_HUMAN Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) NECTIN2 HVEB PRR2 PVRL2 Homo sapiens (Human) acrosome assembly [GO:0001675]; adhesion of symbiont to host [GO:0044406]; cilium organization [GO:0044782]; coreceptor-mediated virion attachment to host cell [GO:0046814]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; establishment of mitochondrion localization [GO:0051654]; fertilization [GO:0009566]; fusion of virus membrane with host plasma membrane [GO:0019064]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of viral entry into host cell [GO:0046596]; sperm mitochondrion organization [GO:0030382]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370] apical junction complex [GO:0043296]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915] cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; virus receptor activity [GO:0001618] FTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVR;VIAKPKNQAEAQK 2 9.1 0.97623 -1.4808 0 0 6.54419 0 0 0 9.90618 9.99619 0 0 0 0 Q92696 PGTA_HUMAN Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) RABGGTA Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968] Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] AVDPMRATYLDDLRSK;FLEVDER 2 4.1 0.95129 -0.7051 0 0 0 7.02569 0 0 0 0 0 0 0 0 Q92698 RAD54_HUMAN DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) RAD54L RAD54A Homo sapiens (Human) determination of adult lifespan [GO:0008340]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; meiotic cell cycle [GO:0051321]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ELTSIVNRCLIR;SHEEQRGLR 2 2.8 0.97882 -1.9161 0 0 0 0 0 0 0 12.5942 0 0 0 11.3991 Q92729 PTPRU_HUMAN Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) PTPRU FMI PCP2 PTPRO Homo sapiens (Human) animal organ regeneration [GO:0031100]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; response to glucocorticoid [GO:0051384]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" CSRYWPEDSDTYGDIK 1 1.1 0.91788 -0.43522 0 0 0 0 0 0 0 0 0 0 0 4.635 Q92730 RND1_HUMAN Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1) RND1 RHO6 Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477]; negative regulation of cell adhesion [GO:0007162]; neuron remodeling [GO:0016322]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102] APQPVVARCK;SELISSTFK 2 8.2 0.95618 -0.84532 0 0 0 0 7.06695 0 0 0 0 0 0 0 Q92731 ESR2_HUMAN Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ESR2 ESTRB NR3A2 Homo sapiens (Human) cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; estrogen receptor signaling pathway [GO:0030520]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; nuclear estrogen receptor activity [GO:0030284]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; receptor antagonist activity [GO:0048019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" SIDHPGK;SLEHTLPVNR 2 3.2 0.9558 -0.88136 0 0 0 0 0 0 0 0 0 0 0 9.96924 Q92736 RYR2_HUMAN Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) RYR2 Homo sapiens (Human) calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling [GO:0019722]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to epinephrine stimulus [GO:0071872]; detection of calcium ion [GO:0005513]; embryonic heart tube morphogenesis [GO:0003143]; establishment of localization in cell [GO:0051649]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; positive regulation of heart rate [GO:0010460]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; striated muscle contraction [GO:0006941]; type B pancreatic cell apoptotic process [GO:0097050]; ventricular cardiac muscle cell action potential [GO:0086005] calcium channel complex [GO:0034704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; suramin binding [GO:0043924]; transmembrane transporter binding [GO:0044325] DIIRSNIHLQGK;DVIDEQGQRNFSKAIQVAK;EVDGMGTSEIK;GDGEEGERKPLEAALPSEDLTDLK;IDGTIDSSPCLK;IEAIVAFSDDFVAK;IIAYQQK;IIYNNLGIDEGAWMKR;KIKVAELLANMPDPTQDEVR;KSNKDSLR;LETLRVAWSGSHIR;LLPIGLNICAPGDQELIALAKNR;LVFDVPLLNEHAKMPLK;LVINTQSFPNNYWDK;LVNHVSSMRPNIFLGVSEGSAQYKK;MYQERCWEFFPAGDCFRK;QLVLTVGLLAVVVYLYTVVAFNFFRK;RLAVFSQPIINKVKPQLLK;VGRRHYCLVEHPQR;VIRSTVFLFNR;VMDKYGEFYGR;VTSLDSSSHR 22 6.9 0.97825 -6.5949 12.598 0 11.8111 11.0507 9.28235 11.3549 9.64839 9.55607 11.9313 7.7705 0 8.15664 Q92737 RSLAA_HUMAN Ras-like protein family member 10A (EC 3.6.5.2) (Ras-like protein RRP22) (Ras-related protein on chromosome 22) RASL10A RRP22 Homo sapiens (Human) small GTPase-mediated signal transduction [GO:0007264] nucleolus [GO:0005730]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] YNWHVLR 1 3.4 0.93978 -0.57831 0 0 0 0 0 0 0 0 0 8.54319 0 0 Q92738 US6NL_HUMAN USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) USP6NL KIAA0019 Homo sapiens (Human) "Golgi organization [GO:0007030]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; regulation of Golgi organization [GO:1903358]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]" cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] HAMHGFFVQGFPK;ILNKFLSKLK;TAKYTMEGK;TFRDHIMFRDR 4 5.2 0.90844 -0.27636 0 0 0 8.45364 0 0 0 0 0 6.47925 8.59872 0 Q92752 TENR_HUMAN Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) "associative learning [GO:0008306]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; synapse organization [GO:0050808]; synaptic transmission, glutamatergic [GO:0035249]; telencephalon cell migration [GO:0022029]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; perineuronal net [GO:0072534]; Schaffer collateral - CA1 synapse [GO:0098685]; tenascin complex [GO:0090733] AEIENYVLTYK;GIGPTTR 2 1.3 0.93701 -0.56294 0 12.4378 12.3765 0 0 0 0 0 8.03755 0 0 7.23496 Q92753 RORB_HUMAN Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) RORB NR1F2 RZRB Homo sapiens (Human) amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; rhythmic process [GO:0048511]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" IPTITAVCNLHGEK;NRCQHCRLQK;VQKLQEKIYFALQHVIQK 3 8.9 0.96478 -1.2493 0 0 0 0 9.2724 10.8711 0 0 0 0 0 0 Q92754 AP2C_HUMAN Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) TFAP2C Homo sapiens (Human) "cell-cell signaling [GO:0007267]; male gonad development [GO:0008584]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" KNMLLAAQQLCK;VTVAEVQR 2 4.4 0.34961 0.23599 0 0 0 0 0 0 0 0 7.52497 0 0 0 Q92759 TF2H4_HUMAN General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) GTF2H4 Homo sapiens (Human) DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; transcription by RNA polymerase II [GO:0006366] core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] ATPase activator activity [GO:0001671]; double-stranded DNA binding [GO:0003690]; RNA polymerase II general transcription initiation factor activity [GO:0016251] DVPSLDK;HARDVPSLDKYAEER 2 3.2 0.95486 -0.878 0 0 0 0 6.93015 0 0 0 7.82699 0 0 11.5051 Q92766 RREB1_HUMAN Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) RREB1 FINB Homo sapiens (Human) "negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CQTCERTFTLK;DREQPSEGATELR;EGLASATKDCSHR;FVCDTCDK;IKQEITEGELK;LCGEDLKHYRALR;TPAMRKVLYPCR 7 4.8 0.97473 -2.3852 0 11.7495 0 0 4.51482 0 0 8.30579 7.70245 0 9.19259 6.22591 Q92769 HDAC2_HUMAN Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) HDAC2 Homo sapiens (Human) behavioral response to ethanol [GO:0048149]; cardiac muscle hypertrophy [GO:0003300]; cellular response to dopamine [GO:1903351]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; dendrite development [GO:0016358]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of male mating behavior [GO:1902437]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteolysis [GO:0045862]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein modification process [GO:0036211]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to amphetamine [GO:0001975]; response to amyloid-beta [GO:1904645]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to hyperoxia [GO:0055093]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]" "chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; NF-kappaB binding [GO:0051059]; promoter-specific chromatin binding [GO:1990841]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; tubulin deacetylase activity [GO:0042903]" QQTDMAVNWAGGLHHAK;QQTDMAVNWAGGLHHAKK 2 3.7 0.11738 0.36133 0 0 0 0 0 8.2417 0 14.7324 0 0 0 0 Q92772 CDKL2_HUMAN Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE) CDKL2 Homo sapiens (Human) sex differentiation [GO:0007548]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EKYENLGLVGEGSYGMVMK 1 3.9 0.94564 -0.65225 0 0 0 0 0 0 0 0 0 10.6644 0 0 Q92777 SYN2_HUMAN Synapsin-2 (Synapsin II) SYN2 Homo sapiens (Human) calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; neurotransmitter secretion [GO:0007269]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; identical protein binding [GO:0042802] IGHAHSGMGKVK 1 2.1 0.88931 -0.18677 0 0 0 0 0 0 0 0 0 9.79949 0 0 Q92781 RDH5_HUMAN Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5) RDH5 HSD17B9 RDH1 SDR9C5 Homo sapiens (Human) retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; visual perception [GO:0007601] cell body [GO:0044297]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "11-cis-retinol dehydrogenase [GO:0106429]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; protein homodimerization activity [GO:0042803]" FGLEAFSDSLRRDVAHFGIR;TLQACWAR;VLASCLTPSGAEDLQR 3 13.8 0.96425 -1.1789 0 0 0 10.2789 0 0 10.7416 11.8747 11.2549 0 0 0 Q92784 DPF3_HUMAN Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) DPF3 BAF45C CERD4 Homo sapiens (Human) chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; SWI/SNF complex [GO:0016514] zinc ion binding [GO:0008270] GSAGGRR 1 2 0.61036 0.17583 0 0 0 0 0 0 0 0 0 9.70638 0 0 Q92786 PROX1_HUMAN Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) PROX1 Homo sapiens (Human) acinar cell differentiation [GO:0090425]; aorta smooth muscle tissue morphogenesis [GO:0060414]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; blood vessel endothelial cell differentiation [GO:0060837]; brain development [GO:0007420]; branching involved in pancreas morphogenesis [GO:0061114]; cerebellar granule cell differentiation [GO:0021707]; circadian rhythm [GO:0007623]; dentate gyrus development [GO:0021542]; dorsal spinal cord development [GO:0021516]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endocardium formation [GO:0060214]; epithelial cell migration [GO:0010631]; hepatocyte cell migration [GO:0002194]; hepatocyte differentiation [GO:0070365]; hepatocyte proliferation [GO:0072574]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; lens placode formation involved in camera-type eye formation [GO:0046619]; liver development [GO:0001889]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; lymphatic endothelial cell fate commitment [GO:0060838]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; olfactory placode formation [GO:0030910]; otic placode formation [GO:0043049]; pancreas development [GO:0031016]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell cycle checkpoint [GO:1901978]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of forebrain neuron differentiation [GO:2000979]; positive regulation of heart growth [GO:0060421]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle thin filament assembly [GO:0030240]; transcription by RNA polymerase II [GO:0006366]; venous blood vessel morphogenesis [GO:0048845]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" DCELYRALNMHYNK;TVGTASAFFAK 2 3.4 0.95544 -0.96783 0 0 0 0 0 0 0 0 0 8.94498 0 11.6756 Q92791 SC65_HUMAN Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65) P3H4 LEPREL4 NOL55 SC65 Homo sapiens (Human) bone remodeling [GO:0046849]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; peptidyl-lysine hydroxylation [GO:0017185]; synaptonemal complex assembly [GO:0007130] catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; synaptonemal complex [GO:0000795] FVATMYHYLQFAYYKLNDVR 1 4.6 0.94687 -0.66027 0 0 0 0 0 0 0 0 11.2546 0 0 0 Q92793 CBP_HUMAN CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) CREBBP CBP Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; embryonic digit morphogenesis [GO:0042733]; homeostatic process [GO:0042592]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]; response to hypoxia [GO:0001666]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; MRF binding [GO:0043426]; p53 binding [GO:0002039]; peptide lactyltransferase (CoA-dependent) activity [GO:0120300]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] FVDSGEMSESFPYR;LGNHLEDR;NVLNHMTHCQAGKACQVAHCASSR;RKLIQQQLVLLLHAHK;VYKFCSK 5 2.8 0.98172 -1.58 0 0 0 0 0 7.7048 0 6.95303 0 6.88935 8.2151 0 Q92794 KAT6A_HUMAN "Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)" KAT6A MOZ MYST3 RUNXBP2 ZNF220 Homo sapiens (Human) cellular senescence [GO:0090398]; chromosome organization [GO:0051276]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; protein acetylation [GO:0006473]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; PML body [GO:0016605] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] DQGKNADNMLFCDSCDRGFHMECCDPPLTR;LIQDHMAK 2 1.9 0.95295 -0.75794 0 0 0 0 0 0 0 0 0 11.0077 0 0 Q92796 DLG3_HUMAN Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) DLG3 KIAA1232 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment of planar polarity [GO:0001736]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; protein localization to synapse [GO:0035418]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625] AVEALKEAGPVVRLVVR;DFPGLSDDYYGAK;HQHCCKCPECYEVTR;NLKGQEDAILSYEPVTR 4 7.6 0.97928 -2.045 0 0 0 0 3.73779 0 0 0 0 8.47921 0 11.3281 Q92797 SYMPK_HUMAN Symplekin SYMPK SPK Homo sapiens (Human) cell adhesion [GO:0007155]; mRNA processing [GO:0006397]; negative regulation of protein binding [GO:0032091] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EVIQALPKLIKLNPIVVK;LAGAGGRK;LGGFVMNILSRLIMKQVWK;LIKLNPIVVK;TVIQSLTMYPR 5 4.4 0.92351 -0.44749 11.7583 4.79556 0 0 0 0 0 0 3.45352 0 0 4.76532 Q92800 EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) EZH1 KIAA0388 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; subtelomeric heterochromatin formation [GO:0031509] "chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; molecular condensate scaffold activity [GO:0140693]; nucleosome binding [GO:0031491]; transcription corepressor activity [GO:0003714] ECDPDLCLTCGASEHWDCK;FCQCNPDCQNRFPGCRCK;LQANMGAK;VQPVQSMKPVSGHPFLKK;YSQADALK 5 9.5 0.92617 -0.45325 12.1773 9.86528 0 0 6.67299 0 0 0 0 0 0 0 Q92802 N42L2_HUMAN NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5) N4BP2L2 CG005 PFAAP5 Homo sapiens (Human) blastocyst development [GO:0001824]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035] extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] LNKLQKLLILLR;LQKLLILLRGLPGSGK;MIYLQWK;MIYLQWKMSVEK;SEIDNELFQFYK;SYGEIEGKFLGPREEVTSEPR;VEFHEPETWWK 7 11.5 0.97944 -1.9986 0 10.0485 6.2287 9.06913 5.63288 4.9771 5.49172 0 11.3848 0 0 0 Q92802 N42L2_HUMAN NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5) N4BP2L2 CG005 PFAAP5 Homo sapiens (Human) blastocyst development [GO:0001824]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035] extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] LFLTFESQTR;MIYLQWK;MIYLQWKMSVEK;VEFHEPETWWK;YSHCLSFNRLRCSASLYK 5 6.8 0.91105 -0.32673 8.69188 0 0 4.43922 0 0 0 0 0 0 0 0 Q92804 RBP56_HUMAN TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) TAF15 RBP56 TAF2N Homo sapiens (Human) mRNA stabilization [GO:0048255]; positive regulation of DNA-templated transcription [GO:0045893]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] GEATVSFDDPPSAK;SGGYGGDRSGGGYGGDR 2 5.2 0.91847 -0.43566 0 0 0 0 0 6.50608 0 0 0 0 0 0 Q92805 GOGA1_HUMAN Golgin subfamily A member 1 (Golgin-97) GOLGA1 Homo sapiens (Human) acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802] EINFEYLK;QDLEQQLLEK 2 2.3 0.95433 -0.90861 14.7003 0 0 0 0 0 0 0 0 0 8.00854 0 Q92806 KCNJ9_HUMAN "G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9)" KCNJ9 GIRK3 Homo sapiens (Human) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of presynaptic membrane potential [GO:0099505] monoatomic ion channel complex [GO:0034702]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242] ELAEAAARLDAHLYWSIPSR 1 5.1 0.91579 -0.43185 0 0 10.353 0 0 0 0 0 0 0 0 0 Q92813 IOD2_HUMAN Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) DIO2 ITDI2 TXDI2 Homo sapiens (Human) hormone biosynthetic process [GO:0042446]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to lipopolysaccharide [GO:0032496]; selenocysteine incorporation [GO:0001514]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403] membrane [GO:0016020]; plasma membrane [GO:0005886] selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]; ubiquitin protein ligase binding [GO:0031625] GEWRRMLTSEGLR 1 4.8 0.84807 -0.071623 0 0 0 0 0 0 12.2548 0 0 0 0 0 Q92817 EVPL_HUMAN Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) EVPL Homo sapiens (Human) epidermis development [GO:0008544]; intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; regulation of antibacterial peptide production [GO:0002786]; wound healing [GO:0042060] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020] cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] ATGDLQRRSR;DLHAKVSR;ELSEDIRRTHDAK;LLSQKTESER;LSGSLDEEVGR;MLEKKELSEDIR;MQANADQVERDILETQK;QIQDADR;QLSALAEQQR;RLTQEIQSR;SGVEKEVEKLLPDLEVLR;SLVGPDAATIRSQYR;VAPLQESIQAQEK;VETKTVSK;VQHELEAQR;VSELQRQRR 16 8.5 0.97864 -8.8454 11.7422 11.1292 7.59857 11.4478 8.50466 10.6789 10.4821 10.3465 0 9.57754 3.23501 0 Q92819 HYAS2_HUMAN Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) HAS2 Homo sapiens (Human) atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; estrous cycle [GO:0044849]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; kidney development [GO:0001822]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of urine volume [GO:0035810]; regulation of extracellular matrix assembly [GO:1901201]; renal water absorption [GO:0070295]; vasculogenesis [GO:0001570] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] GKIWNILLFLLTVQLVGLIK;SLETPIK 2 4.9 0.91123 -0.32678 11.4425 0 0 0 8.17318 8.26627 0 0 8.97143 0 0 0 Q92823 NRCAM_HUMAN Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) NRCAM KIAA0343 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]; synapse assembly [GO:0007416] axon [GO:0030424]; axon initial segment [GO:0043194]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080] TRWTLKNLNFSTR;TVYKNFEK 2 1.6 0.98061 -1.6649 0 0 0 0 0 8.3626 11.3695 0 0 0 0 0 Q92824 PCSK5_HUMAN Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; cytokine precursor processing [GO:0140447]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252] ACETCTGPGHDECSSCQEGLQLLR;AGYEKLADPNK;CAPNCESCFGSHGDQCMSCK;CERCNRSCK;CYSKCPEGSYAEDGICER;IFDDGRCVSNCPSWKFEFENQCHPCHHTCQR;KCAPNCESCFGSHGDQCMSCK;SGSCENCTEACAICSGADLCK 8 7.3 0.97354 -2.5481 0 0 0 0 0 0 10.8547 10.999 0 0 7.01179 7.44526 Q92828 COR2A_HUMAN Coronin-2A (IR10) (WD repeat-containing protein 2) CORO2A IR10 WDR2 Homo sapiens (Human) intracellular signal transduction [GO:0035556] transcription repressor complex [GO:0017053] actin filament binding [GO:0051015] AGTVLQEASYKGHR 1 2.7 0.82947 -0.02263 6.58709 0 0 0 0 0 0 0 0 0 0 0 Q92830 KAT2A_HUMAN Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) KAT2A GCN5 GCN5L2 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; fibroblast proliferation [GO:0048144]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; internal peptidyl-lysine acetylation [GO:0018393]; intracellular distribution of mitochondria [GO:0048312]; limb development [GO:0060173]; long-term memory [GO:0007616]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; negative regulation of centriole replication [GO:0046600]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; peptidyl-lysine glutarylation [GO:0106227]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell projection organization [GO:0031346]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone development [GO:1903010]; regulation of cartilage development [GO:0061035]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA splicing [GO:0043484]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell activation [GO:0050863]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; somitogenesis [GO:0001756]; telencephalon development [GO:0021537] ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; histone acetyltransferase complex [GO:0000123]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone deacetylase binding [GO:0042826]; histone glutaryltransferase activity [GO:0106229]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone succinyltransferase activity [GO:0106078]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713] EYNPPDSEYCRCASALEK;KQAQIRK;LIERKQAQIR;LVFDPKHK;MPKEYIAR;TLILTHFPK 6 6.5 0.97087 -1.339 0 0 0 0 0 0 7.62029 10.2121 0 0 0 0 Q92831 KAT2B_HUMAN Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) KAT2B PCAF Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to parathyroid hormone stimulus [GO:0071374]; chromatin remodeling [GO:0006338]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; limb development [GO:0060173]; memory [GO:0007613]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centriole replication [GO:0046600]; negative regulation of rRNA processing [GO:2000233]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein ADP-ribosylation [GO:0010835]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; rhythmic process [GO:0048511]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vasodilation [GO:0042311] A band [GO:0031672]; actomyosin [GO:0042641]; ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytosol [GO:0005829]; I band [GO:0031674]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124] "acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; diamine N-acetyltransferase activity [GO:0004145]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]" ETGWKPSGKEK;FSHLPAK;KQAQIRK;LIERKQAQIR;LVFDPKHK;TLILTHFPK 6 5.5 0.97354 -2.5473 7.68503 6.84361 7.02614 4.95168 9.45555 5.00459 7.56598 10.5933 11.4699 0 0 0 Q92832 NELL1_HUMAN Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1) NELL1 NRP1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468]; regulation of osteoblast differentiation [GO:0045667] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080] LIQLFRNK;VALSVSASHLLLHVDCNRIYER;VCRGHNFCAEGPK 3 5.3 0.97712 -2.2304 8.32125 0 0 0 0 0 0 0 0 0 0 11.0287 Q92833 JARD2_HUMAN Protein Jumonji (Jumonji/ARID domain-containing protein 2) JARID2 JMJ Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; chromatin remodeling [GO:0006338]; facultative heterochromatin formation [GO:0140718]; liver development [GO:0001889]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to pericentric heterochromatin [GO:1902682]; random inactivation of X chromosome [GO:0060816]; regulation of gene expression [GO:0010468]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538] chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; histone methyltransferase complex [GO:0035097]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K27 methyltransferase activity [GO:0046976]; ubiquitin binding [GO:0043130]; ubiquitin-modified histone reader activity [GO:0061649] CIYKGRSVSLTTFYR;EATPAKEK;EVRPSPSK;GAVTYTK;LAKLQEAYCQYLLSYDSLSPEEHRR;QLFEAGLHSSARYGSHDGSSTVADGK;SVSLTTFYR;VVRKVLYLSLK 8 8 0.97816 -2.139 11.6555 0 0 5.02963 10.4112 5.90864 0 0 11.9208 0 0 8.8885 Q92833 JARD2_HUMAN Protein Jumonji (Jumonji/ARID domain-containing protein 2) JARID2 JMJ Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; chromatin remodeling [GO:0006338]; facultative heterochromatin formation [GO:0140718]; liver development [GO:0001889]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to pericentric heterochromatin [GO:1902682]; random inactivation of X chromosome [GO:0060816]; regulation of gene expression [GO:0010468]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538] chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; histone methyltransferase complex [GO:0035097]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K27 methyltransferase activity [GO:0046976]; ubiquitin binding [GO:0043130]; ubiquitin-modified histone reader activity [GO:0061649] CIYKGRSVSLTTFYR;EATPAKEK;EVRPSPSK;GAVTYTK;GVLGPRL;LAKLQEAYCQYLLSYDSLSPEEHRR;SVSLTTFYR 7 7.3 0.7831 0.024506 0 7.79714 0 0 0 0 0 0 0 0 0 0 Q92834 RPGR_HUMAN X-linked retinitis pigmentosa GTPase regulator RPGR RP3 XLRP3 Homo sapiens (Human) cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750]; sperm flagellum [GO:0036126] guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] EIEKESDGGHSQK;IFLFKRVPSINQK 2 2.5 0.81443 -0.0053251 0 10.5088 0 0 0 0 0 0 0 0 9.08345 0 Q92834 RPGR_HUMAN X-linked retinitis pigmentosa GTPase regulator RPGR RP3 XLRP3 Homo sapiens (Human) cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750]; sperm flagellum [GO:0036126] guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] EEEEEEEGKYQETGEEENERQDGEEYK;ELAEKEEWK;GDGTCEEGSSGAEHWQDEER;GEEEGDQGEGEEEETEGR;NGPSGSK;NQEMEEGGEEEHGEGEEEEGDR;SVTNTQGNGK 7 9.8 0.96464 -1.2215 4.9824 0 7.14088 0 0 0 0 0 0 3.43283 10.4834 10.7007 Q92835 SHIP1_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)" INPP5D SHIP SHIP1 Homo sapiens (Human) apoptotic process [GO:0006915]; determination of adult lifespan [GO:0008340]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of bone resorption [GO:0045779]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of signal transduction [GO:0009968]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]" FLNKLVILVETEK;KLTTLLCKELYGEVIR;VPCWNHGNITRSK;YNLPSWCDR 4 4.3 0.96717 -1.3097 10.8966 7.91486 10.3184 0 0 11.0951 0 0 0 12.3752 0 0 Q92838 EDA_HUMAN "Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]" EDA ED1 EDA2 Homo sapiens (Human) animal organ development [GO:0048513]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; immune response [GO:0006955]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; salivary gland cavitation [GO:0060662]; trachea gland development [GO:0061153] apical part of cell [GO:0045177]; collagen trimer [GO:0005581]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; death receptor agonist activity [GO:0038177]; death receptor binding [GO:0005123]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] VFKLHPR 1 1.8 0.90257 -0.26338 0 0 0 0 0 0 0 0 0 11.0235 0 0 Q92839 HYAS1_HUMAN Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1) HAS1 HAS Homo sapiens (Human) cell adhesion [GO:0007155]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; glycosaminoglycan biosynthetic process [GO:0006024]; hyaluronan biosynthetic process [GO:0030213]; negative regulation of fibroblast migration [GO:0010764] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] FLGTHCTFGDDRHLTNRMLSMGYATK;LAVEALVR;VLMVVDGNRAEDLYMVDMFR;WGGKREVMYTAFK;WLSQQTRWSK 5 13.3 0.9804 -1.6493 0 0 4.67864 7.46809 0 14.1697 8.74029 10.7459 0 8.80471 10.2969 0 Q92841 DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) DDX17 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; immune system process [GO:0002376]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]" APILIATDVASR;APLPDLYPFGTMR;DMVGIAQTGSGK;ESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIR;GGGFGDR;GLDVEDVK;LIDFLESGK;LTPYEVDELRR;MLDMGFEPQIR;NFYVEHPEVAR;RCDDLTRR;VLEEANQAINPK 12 20.2 0 9.6067 11.5292 12.882 13.6788 10.5227 0 6.97292 12.8792 12.5867 13.0255 12.5425 12.068 12.6823 Q92841 DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) DDX17 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; immune system process [GO:0002376]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]" APILIATDVASR;DMVGIAQTGSGK;GGGFGDR;GLDVEDVK;LIDFLESGK;LTPYEVDELRR;MLDMGFEPQIR;MRGGGFGDRDR;NFYVEHPEVAR;RCDDLTRR;VLEEANQAINPK 11 16.1 0.97906 -1.5337 0 0 0 0 0 0 0 8.1441 0 0 0 0 Q92844 TANK_HUMAN TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) TANK ITRAF TRAF2 Homo sapiens (Human) cellular response to interleukin-1 [GO:0071347]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of type I interferon production [GO:0032481]; positive regulation of ubiquitin-specific protease activity [GO:2000158]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554] deubiquitinase activator activity [GO:0035800]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625] ELQQKTENYEQRIR;GAPSITSVTPRGLCR 2 6.8 0.93319 -0.5097 0 0 0 0 0 0 0 0 11.928 0 6.66846 0 Q92845 KIFA3_HUMAN Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) KIFAP3 KIF3AP SMAP Homo sapiens (Human) anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cardiac muscle cell apoptotic process [GO:0010659]; cilium organization [GO:0044782]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of thymocyte apoptotic process [GO:0070244]; neuroblast proliferation [GO:0007405]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of calcium-dependent cell-cell adhesion [GO:0046587]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]; thymocyte apoptotic process [GO:0070242] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; kinesin II complex [GO:0016939]; microtubule cytoskeleton [GO:0015630]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; postsynapse [GO:0098794] intraciliary transport particle B binding [GO:0120170]; kinesin binding [GO:0019894]; protein phosphatase binding [GO:0019903] IGALCMNIIDHELK 1 1.8 0.75877 0.072192 0 0 0 0 0 0 10.0975 0 0 0 0 0 Q92847 GHSR_HUMAN Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; decidualization [GO:0046697]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; learning or memory [GO:0007611]; negative regulation of appetite [GO:0032099]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of appetite [GO:0032100]; positive regulation of eating behavior [GO:1904000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of gastric motility [GO:1905333]; regulation of growth hormone secretion [GO:0060123]; regulation of hindgut contraction [GO:0043134]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of postsynapse organization [GO:0099175]; regulation of synapse assembly [GO:0051963]; regulation of transmission of nerve impulse [GO:0051969]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to L-glutamate [GO:1902065]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060] G protein-coupled receptor activity [GO:0004930]; growth hormone secretagogue receptor activity [GO:0001616]; growth hormone-releasing hormone receptor activity [GO:0016520]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046] ALRLSLAGPILSLCLLPSL 1 6.6 0.82526 -0.020927 0 0 0 7.99113 0 0 0 0 0 0 0 0 Q92851 CASPA_HUMAN Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; proteolysis [GO:0006508] CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625] LLPTRQR;VEMEMVLQK 2 3.1 0.98049 -1.6721 0 0 8.44617 0 0 0 0 0 0 0 0 0 Q92854 SEM4D_HUMAN Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) SEMA4D C9orf164 CD100 SEMAJ Homo sapiens (Human) axon guidance [GO:0007411]; bone trabecula morphogenesis [GO:0061430]; cell adhesion [GO:0007155]; immune response [GO:0006955]; leukocyte aggregation [GO:0070486]; negative chemotaxis [GO:0050919]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] chemorepellent activity [GO:0045499]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] IDDLSAR;QHEVYWK;SNLARVFWK;SNLARVFWKFQNGVLK;VYFFFTEVSVEYEFVFR;YMQSTTVEQSHTK 6 7 0.95562 -0.96744 0 9.04579 7.84229 0 7.60043 0 0 9.33883 0 0 0 0 Q92854 SEM4D_HUMAN Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) SEMA4D C9orf164 CD100 SEMAJ Homo sapiens (Human) axon guidance [GO:0007411]; bone trabecula morphogenesis [GO:0061430]; cell adhesion [GO:0007155]; immune response [GO:0006955]; leukocyte aggregation [GO:0070486]; negative chemotaxis [GO:0050919]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] chemorepellent activity [GO:0045499]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] QHEVYWK;RLSSPWTPWPASGAGPDSSSR;VYFFFTEVSVEYEFVFR;YMQSTTVEQSHTK 4 7.9 0.32646 0.24526 0 0 0 0 0 0 0 0 0 0 9.38967 0 Q92858 ATOH1_HUMAN Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1) ATOH1 ATH1 BHLHA14 Homo sapiens (Human) auditory receptor cell fate determination [GO:0042668]; auditory receptor cell fate specification [GO:0042667]; axon development [GO:0061564]; axon guidance [GO:0007411]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; epithelial cell apoptotic process [GO:1904019]; inner ear morphogenesis [GO:0042472]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gliogenesis [GO:0014014]; neuroblast migration [GO:0097402]; neuron fate commitment [GO:0048663]; neuron migration [GO:0001764]; Notch signaling pathway [GO:0007219]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" LLHAEEWAEVKELGDHHR 1 5.1 0.82587 -0.020106 0 0 0 0 0 0 0 0 0 0 7.02414 0 Q92870 APBB2_HUMAN Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) APBB2 FE65L FE65L1 Homo sapiens (Human) axon guidance [GO:0007411]; extracellular matrix organization [GO:0030198]; intracellular signal transduction [GO:0035556]; maintenance of lens transparency [GO:0036438]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle phase transition [GO:1901988]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; smooth muscle contraction [GO:0006939]; synapse organization [GO:0050808] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090] EPHPQDSSSCEILPSQPRR;FLSFMGVGK;ILKCHVFR;NSPATPPNTLNLR 4 6.5 0.97498 -2.3796 0 0 0 11.7171 0 0 0 0 0 8.58481 8.28665 0 Q92876 KLK6_HUMAN Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) KLK6 PRSS18 PRSS9 Homo sapiens (Human) amyloid precursor protein metabolic process [GO:0042982]; central nervous system development [GO:0007417]; collagen catabolic process [GO:0030574]; hormone metabolic process [GO:0042445]; myelination [GO:0042552]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; regulation of cell differentiation [GO:0045595]; regulation of neuron projection development [GO:0010975]; response to wounding [GO:0009611]; tissue regeneration [GO:0042246] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] LLRLARPAKLSELIQPLPLER 1 15.3 0.8647 -0.083824 0 0 0 0 5.40354 0 0 0 0 0 0 0 Q92878 RAD50_HUMAN DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) RAD50 Homo sapiens (Human) chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; R-loop processing [GO:0062176]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860] "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; membrane [GO:0016020]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase activator activity [GO:0043539]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded telomeric DNA binding [GO:0043047] EMISSLGVSK;GPFSERQIK;IMKLDNEIKALDSR;LIQDQQEQIQHLK;LVDCHRELEKLNK;TVQQVNQEK;TVQQVNQEKQEK;WLQDNLTLRKR 8 6.2 0.97506 -4.1105 11.5273 8.16932 0 11.8267 0 0 0 0 0 7.71898 10.3185 10.7861 Q92879 CELF1_HUMAN CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) CELF1 BRUNOL2 CUGBP CUGBP1 NAB50 Homo sapiens (Human) "embryo development ending in birth or egg hatching [GO:0009792]; germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; post-transcriptional gene silencing [GO:0016441]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of inflammatory response [GO:0050727]; regulation of RNA splicing [GO:0043484]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinucleolar compartment [GO:0097356]; ribonucleoprotein complex [GO:1990904] BRE binding [GO:0042835]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] MFVGQVPR;NNVEDRKLFIGMISK;VLPGMHHPIQMKPADSEK 3 8 0.91853 -0.43581 0 0 0 0 9.26463 9.31872 0 0 0 0 0 9.29554 Q92882 OSTF1_HUMAN Osteoclast-stimulating factor 1 OSTF1 Homo sapiens (Human) ossification [GO:0001503]; signal transduction [GO:0007165] extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] SH3 domain binding [GO:0017124] MSKPPPKPVKPGQVKVFR 1 8.4 0.91956 -0.43797 0 0 8.07307 0 0 0 0 0 0 0 0 0 Q92887 MRP2_HUMAN ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) ABCC2 CMOAT CMOAT1 CMRP MRP2 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; bilirubin transport [GO:0015723]; heme catabolic process [GO:0042167]; leukotriene transport [GO:0071716]; negative regulation of gene expression [GO:0010629]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; intercellular canaliculus [GO:0046581]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bilirubin transmembrane transporter activity [GO:0015127]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910] ALQRRQEK 1 0.5 0.96373 -1.1937 0 0 0 0 0 0 0 0 0 0 10.9495 0 Q92888 ARHG1_HUMAN Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) ARHGEF1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723] DHPHPHSCR;ISSRFCSRQSFALEQLK;LQLKDMIPTEMQR;LTSAMTR;TLTPTPDGK 5 5.8 0.97568 -1.4542 0 0 3.34142 0 0 0 12.3158 0 0 10.8061 0 0 Q92889 XPF_HUMAN DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) ERCC4 ERCC11 XPF Homo sapiens (Human) cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; regulation of autophagy [GO:0010506]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650] "chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]" damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; TFIID-class transcription factor complex binding [GO:0001094] HEEFDVNLSSDAAFGILK;IIESCQEAFILRLFR 2 3.6 0.44288 0.19343 0 0 0 0 8.47861 0 0 0 0 3.04313 0 0 Q92896 GSLG1_HUMAN Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) GLG1 CFR1 ESL1 MG160 Homo sapiens (Human) bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein processing [GO:0016485]; regulation of chondrocyte differentiation [GO:0032330]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] fibroblast growth factor binding [GO:0017134]; signaling receptor binding [GO:0005102] ECRAEVQR;ESKADIFVDPVLHTACALDIK;GRQMSCLMEALEDKR;HIRSGDPMILSCLMEHLYTEKMVEDCEHR;SETMAYK;VEELEMTEDIR;VEELEMTEDIRLEPDLYEACKSDIK 7 8.8 0.97682 -4.9106 0 5.17341 0 0 0 0 11.2096 0 11.1863 0 9.25293 9.8962 Q92900 RENT1_HUMAN Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) UPF1 KIAA0221 RENT1 Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; supraspliceosomal complex [GO:0044530]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270] AGAKPDQIGIITPYEGQR;DGPLGETVLECYNCGCR;ESQTQDNITVR;GDLAPLWK;GTPKGKTGR;IPSEQEQLRARQITAQQINK;LEADYDKKLK;LVNTINPGAR 8 9.1 0.97442 -2.4427 0 6.69585 0 0 0 3.73671 0 7.32472 9.73283 10.1018 9.435 6.27689 Q92901 RL3L_HUMAN Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like) RPL3L Homo sapiens (Human) negative regulation of myotube differentiation [GO:0010832]; regulation of striated muscle tissue development [GO:0016202]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FIDTTSK;FIDTTSKFGHGR;VAWAQAR;VAWAQARLEK;VIVHTQMK 5 7.4 0.97227 -2.8341 0 0 0 0 0 10.6789 0 0 0 0 0 0 Q92902 HPS1_HUMAN BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein) HPS1 HPS Homo sapiens (Human) intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601] BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosome [GO:0005764] guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983] GAQEIQSTWLEFK;IFLDANVK 2 3 0.91578 -0.37611 0 0 0 0 0 0 0 0 0 0 0 11.9982 Q92904 DAZL_HUMAN Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal) DAZL DAZH DAZL1 DAZLA SPGYLA Homo sapiens (Human) 3'-UTR-mediated mRNA stabilization [GO:0070935]; germ cell development [GO:0007281]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; translation activator activity [GO:0008494] STANPETPNSTISREASTQSSSAATSQGYILPEGK;YGSVKEVKIITDR 2 16.3 0.8694 -0.09956 7.00888 0 0 10.026 0 0 0 0 0 0 0 0 Q92911 SC5A5_HUMAN Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) SLC5A5 NIS Homo sapiens (Human) cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to Thyroid stimulating hormone [GO:1904401]; iodide transmembrane transport [GO:1904200]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; sodium ion transport [GO:0006814]; thyroid hormone generation [GO:0006590]; transport across blood-brain barrier [GO:0150104] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] iodide transmembrane transporter activity [GO:0015111]; monoatomic anion:sodium symporter activity [GO:0015373]; protein homodimerization activity [GO:0042803]; sodium:iodide symporter activity [GO:0008507] GGQRSAEDFFTGGRR 1 2.3 0.8512 -0.079481 5.90169 0 0 0 0 0 0 0 0 0 0 0 Q92913 FGF13_HUMAN Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) FGF13 FHF2 Homo sapiens (Human) branching morphogenesis of a nerve [GO:0048755]; cell-cell signaling [GO:0007267]; cerebral cortex cell migration [GO:0021795]; establishment of neuroblast polarity [GO:0045200]; hippocampus development [GO:0021766]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; microtubule polymerization [GO:0046785]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; protein localization to plasma membrane [GO:0072659]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; signal transduction [GO:0007165]; sodium ion transport [GO:0006814] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] beta-tubulin binding [GO:0048487]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] NKLNVFSR;VAMYKEPSLHDLTEFSR 2 10.2 0.95261 -0.7695 0 0 0 0 10.2492 0 0 0 8.85925 0 0 0 Q92913 FGF13_HUMAN Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) FGF13 FHF2 Homo sapiens (Human) branching morphogenesis of a nerve [GO:0048755]; cell-cell signaling [GO:0007267]; cerebral cortex cell migration [GO:0021795]; establishment of neuroblast polarity [GO:0045200]; hippocampus development [GO:0021766]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; microtubule polymerization [GO:0046785]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; protein localization to plasma membrane [GO:0072659]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; signal transduction [GO:0007165]; sodium ion transport [GO:0006814] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] beta-tubulin binding [GO:0048487]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] EEKDASKEPQLK;VAMYKEPSLHDLTEFSR 2 14.6 0.96161 -1.0663 0 0 0 9.48224 0 0 0 0 0 0 0 0 Q92915 FGF14_HUMAN Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) FGF14 FHF4 Homo sapiens (Human) cell-cell signaling [GO:0007267]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080] VKPVPLFR 1 3.2 0.91582 -0.39033 0 0 0 0 0 0 6.79025 0 0 0 0 0 Q92918 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) MAP4K1 HPK1 Homo sapiens (Human) cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VAGITGL;VTLTKSPK 2 1.8 0.88232 -0.17557 0 0 0 0 9.39053 8.62308 10.2352 0 10.4524 9.87506 0 0 Q92922 SMRC1_HUMAN SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) SMARCC1 BAF155 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; chromatin remodeling [GO:0006338]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] brahma complex [GO:0035060]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; male germ cell nucleus [GO:0001673]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741] chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713] QRISTKNEEPVR;VASAAAK 2 1.7 0.86991 -0.09468 0 0 7.03232 0 0 0 8.33642 0 0 0 0 0 Q92925 SMRD2_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) SMARCD2 BAF60B PRO2451 Homo sapiens (Human) chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DLKIITDVIGNPEEERR;LLDDPSK;LRFSEIPMK 3 6.2 0.94198 -0.61981 0 0 0 0 0 0 0 0 0 0 0 10.9338 Q92930 RAB8B_HUMAN Ras-related protein Rab-8B RAB8B Homo sapiens (Human) antigen processing and presentation [GO:0019882]; cell-substrate junction organization [GO:0150115]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; positive regulation of cell projection organization [GO:0031346]; positive regulation of corticotropin secretion [GO:0051461]; protein import into peroxisome membrane [GO:0045046] cell tip [GO:0051286]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911] CDMNDKR;LLLIGDSGVGK;TIELDGK 3 12.1 0.60907 0.17525 0 0 0 0 12.0321 0 0 0 0 0 0 7.44989 Q92932 PTPR2_HUMAN Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] PTPRN2 KIAA0387 Homo sapiens (Human) insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; lipid metabolic process [GO:0006629]; neurotransmitter secretion [GO:0007269]; protein dephosphorylation [GO:0006470]; regulation of secretion [GO:0051046] ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DLQRQPAEVR;GPPLPLLLLLLLLLPPR;NLQTNETR;SGTYVLIDMVLNKMAK;SLAVLTYDHSR;TVTQFHFLSWYDR;YEVSPVALQRLRVALQK 7 9.1 0.67427 0.16666 0 4.85539 0 0 0 0 0 0 0 3.21305 0 0 Q92932 PTPR2_HUMAN Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] PTPRN2 KIAA0387 Homo sapiens (Human) insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; lipid metabolic process [GO:0006629]; neurotransmitter secretion [GO:0007269]; protein dephosphorylation [GO:0006470]; regulation of secretion [GO:0051046] ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DLQRQPAEVR;NLQTNETR;SGTYVLIDMVLNKMAK;SLAVLTYDHSR;TVTQFHFLSWYDR;VEVMFVSGPQTRER;YEVSPVALQRLRVALQK 7 8.6 0.97446 -3.6234 10.9193 0 0 8.86833 0 0 0 8.6393 0 0 0 12.673 Q92935 EXTL1_HUMAN Exostosin-like 1 (EC 2.4.1.224) (Exostosin-L) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein) EXTL1 EXTL Homo sapiens (Human) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486]; skeletal system development [GO:0001501] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020] GRNHLVLRLHPAPCPR;LDPVLFK 2 3.4 0.96377 -1.1107 0 9.54674 0 0 0 0 0 11.3133 0 0 0 0 Q92945 FUBP2_HUMAN Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) KHSRP FUBP2 Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to cytokine stimulus [GO:0071345]; miRNA metabolic process [GO:0010586]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723] IGGDAATTVNNSTPDFGFGGQKR;IGGGIDVPVPR;IINDLLQSLR;IQNDAGVR;LASQGDSISSQLGPIHPPPR;MMLDDIVSR;SVSLTGAPESVQK;VQISPDSGGLPER 8 15 0 23.935 11.4915 12.2816 12.3759 7.65378 0 0 12.1278 0 11.4653 11.3012 10.5786 0 Q92947 GCDH_HUMAN "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)" GCDH Homo sapiens (Human) fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; tryptophan metabolic process [GO:0006568] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; glutaryl-CoA dehydrogenase activity [GO:0004361] TYCQERLMPR 1 2.3 0.88622 -0.18184 0 0 0 0 0 0 0 9.61741 0 0 0 0 Q92952 KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (hSK1) (KCa2.1) KCNN1 SK Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018] calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286] GQPQDQDDDEDDEEDEAGR;IEQGKLNDQANTLTDLAK;KFLQAIHQAQKLR;LATLESR 4 10.5 0.95261 -0.68189 12.2224 0 13.1704 0 10.476 0 6.98197 0 4.44506 0 0 0 Q92953 KCNB2_HUMAN Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) KCNB2 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of smooth muscle contraction [GO:0006940] dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; protein heterodimerization activity [GO:0046982] EGEEFDNTCCPDK;HSTGLQSLGFTLR;LEMLYNEITK 3 4 0.92859 -0.46198 0 0 11.5045 0 6.2484 0 0 0 0 0 0 5.15097 Q92954 PRG4_HUMAN Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] PRG4 MSF SZP Homo sapiens (Human) immune response [GO:0006955] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] DATCNCDYNCQHYMECCPDFK;DATCNCDYNCQHYMECCPDFKR;DQYYNIDVPSR;YDKCCPDYESFCAEVHNPTSPPSSK 4 4.1 0.36601 0.23136 0 0 0 0 0 5.67378 7.41802 0 0 8.71589 5.54717 10.3285 Q92956 TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270) TNFRSF14 HVEA HVEM UNQ329/PRO509 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of T cell migration [GO:2000406]; T cell costimulation [GO:0031295] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618] ASRNCSR 1 2.5 0.98103 -1.5757 0 0 0 0 0 0 0 0 0 9.88733 0 0 Q92959 SO2A1_HUMAN Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2) SLCO2A1 OATP2A1 SLC21A2 Homo sapiens (Human) lipid transport [GO:0006869]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886] lipid transporter activity [GO:0005319]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] AGRCARSVFGNIK;DCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSK;RAPATADEAR 3 9.6 0.9651 -1.2487 6.96405 11.9043 11.9398 0 0 0 11.6016 0 0 0 0 0 Q92963 RIT1_HUMAN GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) RIT1 RIBB RIT ROC1 Homo sapiens (Human) Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165] plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] YYIDDVFHALVREIRR 1 7.3 0.4807 0.19043 0 0 0 0 0 6.13221 0 0 0 0 0 0 Q92966 SNPC3_HUMAN snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) SNAPC3 SNAP50 Homo sapiens (Human) snRNA transcription [GO:0009301]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185] bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] AVCGLDK;DLYKSAFFYFEGTFYNDK;TIIEWSESHDR 3 8.8 0.92761 -0.45914 0 10.816 11.1002 0 7.52591 0 0 8.97536 8.64389 0 0 0 Q92973 TNPO1_HUMAN Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) TNPO1 KPNB2 MIP1 TRN Homo sapiens (Human) protein import into nucleus [GO:0006606] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] ELLFHHEWVVK;ESQSPDTTIQR;LAAFYGV;QSSFALLGDLTK;TVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRK 5 8.4 0.78068 0.032566 0 7.91091 10.9189 0 0 0 0 0 8.56522 0 5.38484 0 Q92974 ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) ARHGEF2 KIAA0651 LFP40 Homo sapiens (Human) actin filament organization [GO:0007015]; asymmetric neuroblast division [GO:0055059]; cell morphogenesis [GO:0000902]; cellular hyperosmotic response [GO:0071474]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of necroptotic process [GO:0060546]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron migration [GO:2001224]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; spindle [GO:0005819]; vesicle [GO:0031982] guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] IDRSRELASK;ILQHSHGIEEER;QQDVIYELIQTELHHVRTLK 3 4.3 0.9154 -0.34539 0 0 0 0 9.42677 0 0 0 0 0 7.46271 0 Q92979 NEP1_HUMAN Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) EMG1 C2F Homo sapiens (Human) blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843] IPRTFDRFCGLMVQLLHK 1 7.4 0.54841 0.18358 0 0 0 0 0 0 0 0 0 0 4.10182 0 Q92985 IRF7_HUMAN Interferon regulatory factor 7 (IRF-7) IRF7 Homo sapiens (Human) cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; establishment of viral latency [GO:0019043]; immune system process [GO:0002376]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of adaptive immune response [GO:0002819]; regulation of immune response [GO:0050776]; regulation of monocyte differentiation [GO:0045655]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GSPRYTIYLGFGQDLSAGRPK;STRRFVMLR;TNFRCALR;WPPSSRGGGPPPEAETAER 4 11.3 0.97698 -2.1736 0 10.9085 0 14.2573 9.56562 0 0 0 0 0 0 0 Q92990 GLMN_HUMAN Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) GLMN FAP48 FAP68 VMGLOM Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; epigenetic regulation of gene expression [GO:0040029]; muscle cell differentiation [GO:0042692]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of phosphorylation [GO:0042327]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737] hepatocyte growth factor receptor binding [GO:0005171]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105] EQIQMDDYGLCQCCK 1 2.5 0.64853 0.17045 0 0 0 6.26072 0 0 7.80252 0 7.01179 5.13406 0 0 Q92993 KAT5_HUMAN Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) KAT5 HTATIP TIP60 Homo sapiens (Human) "apoptotic process [GO:0006915]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of mitotic spindle orientation [GO:0000132]; innate immune response [GO:0045087]; lipid droplet disassembly [GO:1905691]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nucleotide-excision repair [GO:0006289]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of aggrephagy [GO:1905337]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of innate immune response [GO:0045089]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein acetylation [GO:1901985]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; piccolo histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812]; transcription regulator complex [GO:0005667] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone crotonyltransferase activity [GO:0140068]; histone H2A acetyltransferase activity [GO:0043998]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; peptide lactyltransferase (CoA-dependent) activity [GO:0120300]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] EPGEVGR;GTISFFEIDGRK;RGYGKLLIEFSYELSK 3 6.4 0.9547 -0.82307 0 0 0 0 0 0 0 0 0 0 10.1688 0 Q92994 TF3B_HUMAN "Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)" BRF1 BRF GTF3B TAF3B2 TAF3C Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] IDLEEECDPPIEEGGQTEAR 1 14.9 0.78306 0.025586 0 0 0 0 0 0 0 0 0 0 8.29857 0 Q92994 TF3B_HUMAN "Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)" BRF1 BRF GTF3B TAF3B2 TAF3C Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] CASRISVAGLCCLPSQEVLVCRMR 1 9.9 0.86915 -0.096878 0 0 0 0 0 0 0 0 6.53745 0 0 0 Q92994 TF3B_HUMAN "Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)" BRF1 BRF GTF3B TAF3B2 TAF3C Homo sapiens (Human) DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] AKSQPHFPVLAQYILNESEARVK;EAIEKMLEQK;ENAEYLREQREK;SGADPVTSVGK 4 9.6 0.98144 -1.7724 12.1054 0 0 9.63105 0 6.51265 0 0 0 0 10.3677 0 Q92995 UBP13_HUMAN Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) USP13 ISOT3 Homo sapiens (Human) autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein [GO:0036506]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein deubiquitination [GO:0016579]; protein K29-linked deubiquitination [GO:0035523]; protein K6-linked deubiquitination [GO:0044313]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] BAT3 complex binding [GO:1904288]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270] EGRWVIYNDHKVCASERPPK;KVRYTER;VPRSGDR 3 3.9 0.95391 -0.88912 0 0 0 0 10.2285 0 0 0 0 0 0 0 Q92997 DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) DVL3 KIAA0208 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; intracellular signal transduction [GO:0035556]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" chromatin [GO:0000785]; cytosol [GO:0005829] beta-catenin binding [GO:0008013]; frizzled binding [GO:0005109]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] LNGTAKGERR 1 1.4 0.97274 -1.3686 0 0 11.0649 0 0 0 0 0 0 0 0 0 Q93008 USP9X_HUMAN "Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" USP9X DFFRX FAM USP9 Homo sapiens (Human) "amyloid fibril formation [GO:1990000]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cell migration [GO:0016477]; chromosome segregation [GO:0007059]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; DNA alkylation repair [GO:0006307]; female gamete generation [GO:0007292]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of protein binding [GO:0032092]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein K63-linked deubiquitination [GO:0070536]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of protein stability [GO:0031647]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179]" centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; deubiquitinase activity [GO:0101005]; K11-linked deubiquitinase activity [GO:0180017]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; molecular sequestering activity [GO:0140313] GFWKQFRLWGEPVNLR;GGANLIK;NNFLPNADMETR;QVAQEQFFLMCTR;RKWTWAVEWLGDELER;VISSVSYYTHRHGNPEEEEWLTAER 6 3.5 0.97485 -1.4275 0 0 0 0 9.04821 0 0 0 0 16.0402 9.15297 0 Q93009 UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 HAUSP Homo sapiens (Human) "DNA alkylation repair [GO:0006307]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of establishment of protein localization to telomere [GO:0070203]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; rhythmic process [GO:0048511]; symbiont-mediated disruption of host cell PML body [GO:0075342]; transcription-coupled nucleotide-excision repair [GO:0006283]" chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039] AVYMMPTEGDDSSK;FYPDRPHQK;GTCVEGTIPK;IQDYDVSLDK;ISHLFFHK;LNTDPMLLQFFKSQGYR;LWPMQAR;LYYQQLK;SFSRRISHLFFHK 9 7.9 0.97458 -3.1022 0 0 0 7.46557 9.45333 8.71836 0 12.755 8.71153 11.601 0 0 Q93015 NAA80_HUMAN N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) NAA80 FUS2 NAT6 Homo sapiens (Human) actin modification [GO:0030047]; N-terminal peptidyl-aspartic acid acetylation [GO:0017190]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; protein acetylation [GO:0006473]; regulation of actin polymerization or depolymerization [GO:0008064] cytoplasm [GO:0005737]; cytosol [GO:0005829] acetyl-CoA binding [GO:1905502]; N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596] SLLETQYQNVR 1 3.8 0.84977 -0.078074 0 0 0 0 0 0 12.3433 0 0 0 0 0 Q93033 IGSF2_HUMAN Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101) CD101 EWI101 IGSF2 V7 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; positive regulation of myeloid leukocyte differentiation [GO:0002763] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]" SGDVYVER;SGLTELK 2 1.5 0.95453 -0.88601 0 0 0 0 0 0 11.1015 8.6581 0 0 0 0 Q93034 CUL5_HUMAN Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) CUL5 VACM1 Homo sapiens (Human) ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; reelin-mediated signaling pathway [GO:0038026]; regulation of neuron migration [GO:2001222]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; site of DNA damage [GO:0090734] calcium channel activity [GO:0005262]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] GVGLKTQPESK;KLMLDTWNESIFSNIK;LTSEEIEAK;YVQNKDVFMR;YVQNKDVFMRYHK 5 6.3 0.90943 -0.31709 0 8.42572 0 0 0 9.44756 6.18458 0 0 0 10.1101 0 Q93038 TNR25_HUMAN Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1) TNFRSF25 APO3 DDR3 DR3 TNFRSF12 WSL WSL1 UNQ455/PRO779 Homo sapiens (Human) apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031] MEQRPRGCAAVAAALLLVLLGAR 1 5.4 0.83427 -0.029624 0 0 0 0 0 0 0 0 4.14967 0 0 0 Q93045 STMN2_HUMAN Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) STMN2 SCG10 SCGN10 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; microtubule depolymerization [GO:0007019]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471] calcium-dependent protein binding [GO:0048306]; tubulin binding [GO:0015631] ALEENNNFSK;DLSLEEIQK;LVKFISSELK;NINIYTYDDMEVKQINK 4 24.6 0.25356 0.276 0 0 0 10.3758 0 0 0 10.055 8.59122 10.0725 10.8149 0 Q93050 VPP1_HUMAN V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) ATP6V0A1 ATP6N1 ATP6N1A VPP1 Homo sapiens (Human) endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DLNPDVNVFQR;VLQAAAK 2 2.2 0.93604 -0.53587 0 0 0 0 3.73292 0 0 0 0 9.02481 0 0 Q93052 LPP_HUMAN Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) LPP Homo sapiens (Human) cell-cell adhesion [GO:0098609] cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] metal ion binding [GO:0046872] KFAPRCSVCK 1 1.6 0.76695 0.059134 0 0 0 0 0 0 0 0 9.72209 0 0 0 Q93062 RBPMS_HUMAN RNA-binding protein with multiple splicing (RBP-MS) (RBPMS) (Heart and RRM expressed sequence) (Hermes) RBPMS HERMES Homo sapiens (Human) "protein-containing complex assembly [GO:0065003]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to oxidative stress [GO:0006979]; RNA processing [GO:0006396]; SMAD protein signal transduction [GO:0060395]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] molecular adaptor activity [GO:0060090]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] WLPPSEATSQGWKSR 1 7.7 0.82584 -0.019379 0 0 0 0 0 0 0 0 0 6.78816 0 0 Q93062 RBPMS_HUMAN RNA-binding protein with multiple splicing (RBP-MS) (RBPMS) (Heart and RRM expressed sequence) (Hermes) RBPMS HERMES Homo sapiens (Human) "protein-containing complex assembly [GO:0065003]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to oxidative stress [GO:0006979]; RNA processing [GO:0006396]; SMAD protein signal transduction [GO:0060395]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] molecular adaptor activity [GO:0060090]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] LVGTPNPSTPLPNTVPQFIAREPLGGANEHGER 1 23.1 0.94092 -0.6078 0 0 0 9.21167 9.27575 8.88475 0 0 11.5715 0 0 0 Q93063 EXT2_HUMAN Exostosin-2 (EC 2.4.1.224) (Exostosin glycosyltransferase 2) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 2) EXT2 Homo sapiens (Human) "cellular response to fibroblast growth factor stimulus [GO:0044344]; chondrocyte differentiation [GO:0002062]; endochondral bone morphogenesis [GO:0060350]; fluid transport [GO:0042044]; gene expression [GO:0010467]; glycosaminoglycan biosynthetic process [GO:0006024]; heart contraction [GO:0060047]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mesoderm formation [GO:0001707]; multicellular organismal-level water homeostasis [GO:0050891]; ossification [GO:0001503]; polysaccharide biosynthetic process [GO:0000271]; protein N-linked glycosylation [GO:0006487]; regulation of blood pressure [GO:0008217]; sodium ion homeostasis [GO:0055078]; sulfation [GO:0051923]; vasodilation [GO:0042311]" catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; UDP-N-acetylglucosamine transferase complex [GO:0043541] glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982] LVGYPGR;VVEHRADPVLYK 2 2.6 0.95272 -0.73705 8.48265 7.64133 0 0 0 0 0 0 0 0 0 0 Q93070 NAR4_HUMAN Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 4) (ARTC4) (Dombrock blood group carrier molecule) (Mono(ADP-ribosyl)transferase 4) (NAD(P)(+)--arginine ADP-ribosyltransferase 4) (CD antigen CD297) ART4 DO DOK1 Homo sapiens (Human) arginine metabolic process [GO:0006525] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779] AMASVAR 1 2.2 0.78716 0.017592 0 0 0 0 7.56499 7.58263 0 0 0 11.2957 0 9.68013 Q93073 SBP2L_HUMAN Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) SECISBP2L KIAA0256 Homo sapiens (Human) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368] RPTALKKVILK;SLSETTATMLWKSKGR 2 2.5 0.97684 -1.4971 0 0 4.68415 0 4.26739 0 6.52525 0 0 0 4.26153 0 Q93074 MED12_HUMAN Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230 Homo sapiens (Human) "axis elongation involved in somitogenesis [GO:0090245]; embryonic brain development [GO:1990403]; embryonic neurocranium morphogenesis [GO:0048702]; endoderm development [GO:0007492]; heart development [GO:0007507]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-anal tail morphogenesis [GO:0036342]; protein ubiquitination [GO:0016567]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] ELGERQSDSLEK;GEEQQRLLLYHTHLRPRPR;KEEVFGYLAKYTVPVMR;KLQKELGER;LTCRILLHLFK;NVSFNPAK;QAEIEAER 7 3.6 0.97447 -3.059 0 0 0 0 0 0 0 7.43962 10.3747 11.3132 9.72241 9.53126 Q93075 TATD2_HUMAN Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; nuclease activity [GO:0004518] LSFQGTFTK;VKHNWSSTSEGCPR 2 3 0.96316 -1.0995 12.301 0 0 0 0 0 11.7301 0 0 10.8297 0 0 Q93077 H2A1C_HUMAN Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) H2AC6 H2AFL HIST1H2AC Homo sapiens (Human) heterochromatin formation [GO:0031507]; negative regulation of cell population proliferation [GO:0008285] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AGLQFPVGR;HLQLAIR;KGNYAER;LLGRVTIAQGGVLPNIQAVLLPKK;NDEELNK;VTIAQGGVLPNIQAVLLPK;VTIAQGGVLPNIQAVLLPKK 7 41.5 0.62924 0.1736 0 0 0 0 4.39643 0 0 0 0 0 0 0 Q93083 MT1L_HUMAN Metallothionein-1L (MT-1L) (Metallothionein-IL) (MT-IL) MT1L Homo sapiens (Human) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCATGGSCSCASSCKCK;SCCSCCPMGCAK;SCCSCCPMGCAKCAQGCVCK 3 67.2 0.92389 -0.44955 0 0 0 6.39451 8.42576 0 0 6.26767 0 8.74507 8.59801 0 Q93084 AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) ATP2A3 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of receptor binding [GO:1900121]; regulation of cardiac conduction [GO:1903779]; transport across blood-brain barrier [GO:0150104] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; organelle membrane [GO:0031090]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-dependent ATPase activity [GO:0030899]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; transmembrane transporter binding [GO:0044325] GAVYYFK;TAPLTPTSR;TGTLTTNQMSVCR;VDQSILTGESVSVTK;VEPAHKSR;VESPVCTSD;VGEATETALTCLVEK 7 7.4 0.97212 -2.8223 0 0 10.3129 0 10.4785 0 9.068 0 0 0 0 0 Q93086 P2RX5_HUMAN P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor) P2RX5 P2X5 P2X5FL Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; chloride transport [GO:0006821]; nervous system development [GO:0007399]; osteoclast maturation [GO:0036179]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; regulation of skeletal muscle tissue regeneration [GO:0043416]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to pH [GO:0009268]; response to zinc ion [GO:0010043]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; ATP-gated ion channel activity [GO:0035381]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic anion channel activity [GO:0099095]; monoatomic ion channel activity [GO:0005216]; purinergic nucleotide receptor activity [GO:0001614]; transmembrane signaling receptor activity [GO:0004888]; voltage-gated monoatomic ion channel activity [GO:0005244] FDVMVNGK;GQAGCKGLCLSLFDYK;LLQASILAYLVVWVFLIKK;TEKYVIAK;TLMKAYGIRFDVMVNGK 5 13.5 0.97809 -1.5088 0 0 0 0 0 0 0 0 6.71507 0 11.352 9.82329 Q93088 BHMT1_HUMAN Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) BHMT Homo sapiens (Human) 'de novo' L-methionine biosynthetic process [GO:0071266]; amino-acid betaine catabolic process [GO:0006579]; amino-acid betaine metabolic process [GO:0006577]; L-methionine salvage [GO:0071267]; protein methylation [GO:0006479]; regulation of homocysteine metabolic process [GO:0050666] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] betaine-homocysteine S-methyltransferase activity [GO:0047150]; zinc ion binding [GO:0008270] LMKEGLEAAR 1 2.5 0.96258 -1.1029 13.0558 0 0 0 0 0 0 0 0 0 0 0 Q93097 WNT2B_HUMAN Protein Wnt-2b (Protein Wnt-13) WNT2B WNT13 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; chondrocyte differentiation [GO:0002062]; cornea development in camera-type eye [GO:0061303]; forebrain regionalization [GO:0021871]; hematopoietic stem cell proliferation [GO:0071425]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; male gonad development [GO:0008584]; mesenchymal-epithelial cell signaling [GO:0060638]; neuron differentiation [GO:0030182]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] ALMNLHNNRCGR;CGRTAVR;GTDGCEIMCCGR 3 7.5 0.97367 -1.41 0 0 12.2091 0 9.40905 0 0 0 0 7.46589 0 0 Q93098 WNT8B_HUMAN Protein Wnt-8b WNT8B Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; determination of dorsal identity [GO:0048263]; gastrulation [GO:0007369]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] NCSLGDFDNCGCDDSR 1 4.6 0.60027 0.17734 0 0 0 0 0 0 0 0 0 0 3.39081 0 Q93099 HGD_HUMAN "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" HGD HGO Homo sapiens (Human) L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; extracellular exosome [GO:0070062] "homogentisate 1,2-dioxygenase activity [GO:0004411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" MLVQPNEICVIQRGMR 1 3.6 0.91579 -0.43091 0 0 0 0 0 0 8.60752 0 0 0 0 0 Q93100 KPBB_HUMAN Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) PHKB Homo sapiens (Human) generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516] GILYCYMRQADK;RSGSVYEPLK;VIQNIIYYK;VLERRAR 4 3.5 0.97905 -1.5328 0 0 0 0 9.5398 9.53403 0 0 0 5.01975 0 0 Q969D9 TSLP_HUMAN Thymic stromal lymphopoietin TSLP Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; interleukin-7-mediated signaling pathway [GO:0038111]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-C motif) ligand 1 production [GO:0071654]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-7 receptor binding [GO:0005139] CLEQVSQLQGLWR 1 20.6 0.80237 0.014412 0 10.0301 0 0 0 0 0 0 0 0 0 0 Q969E1 LEAP2_HUMAN Liver-expressed antimicrobial peptide 2 (LEAP-2) LEAP2 Homo sapiens (Human) defense response to bacterium [GO:0042742] extracellular region [GO:0005576] DDSECITRLCR 1 14.3 0.92101 -0.44477 0 0 6.64818 0 0 0 0 0 0 0 0 0 Q969E3 UCN3_HUMAN Urocortin-3 (Stresscopin) (Urocortin III) (Ucn III) UCN3 SPC Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of insulin secretion [GO:0032024]; positive regulation of membrane potential [GO:0045838]; response to corticosterone [GO:0051412]; response to glucose [GO:0009749]; response to immobilization stress [GO:0035902]; response to starvation [GO:0042594] axon terminus [GO:0043679]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; varicosity [GO:0043196] corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179] SFHYLRSR 1 5 0.91321 -0.33804 0 0 0 0 0 0 0 0 0 9.49486 0 0 Q969E4 TCAL3_HUMAN Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) TCEAL3 MSTP072 Homo sapiens (Human) nucleus [GO:0005634] GLHDIPYL;KTDRGTDDSPK 2 9.5 0.91416 -0.32985 0 0 0 0 0 0 8.43771 7.94398 0 6.82349 0 0 Q969F0 FATE1_HUMAN Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2) FATE1 FATE Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] AAGSASAK;ALEEQGATWRHR 2 10.9 0.91615 -0.34729 10.2623 0 0 0 0 0 0 0 8.65685 0 0 0 Q969F2 NKD2_HUMAN Protein naked cuticle homolog 2 (Naked-2) (hNkd2) NKD2 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi vesicle fusion to target membrane [GO:0048210]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein processing [GO:0010954]; protein localization to plasma membrane [GO:0072659]; Wnt signaling pathway [GO:0016055] basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; molecular adaptor activity [GO:0060090]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625] DKQELPNGDPKEGPFR 1 3.5 0.84958 -0.076354 0 0 0 0 0 0 0 0 0 6.19515 0 0 Q969F9 HPS3_HUMAN BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) HPS3 Homo sapiens (Human) intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155] BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769] MIGHNVEGPFSK;SHSEMKLVCGFILEPR 2 2.8 0.95485 -0.9004 0 0 0 0 0 0 0 0 8.42286 0 0 0 Q969G2 LHX4_HUMAN LIM/homeobox protein Lhx4 (LIM homeobox protein 4) LHX4 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyl-CpG binding [GO:0008327]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" RSRGSSK 1 1.8 0.8108 -0.014478 0 0 0 8.19554 0 0 0 0 0 6.66832 0 0 Q969G3 SMCE1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) SMARCE1 BAF57 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; N-acetyltransferase activity [GO:0008080]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] IAAEIAQAEEQARKR 1 3.6 0.97768 -1.5144 0 0 0 0 0 0 0 0 0 0 0 12.1012 Q969G9 NKD1_HUMAN Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) NKD1 NKD PP7246 Homo sapiens (Human) "axis elongation [GO:0003401]; convergent extension [GO:0060026]; eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; PDZ domain binding [GO:0030165] AETKPTEDLR;EHLRELPALVVYESQAGQPVQR 2 6.8 0.93304 -0.50929 0 0 0 0 0 0 0 10.1939 0 0 0 0 Q969H0 FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; lipid homeostasis [GO:0055088]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein localization [GO:0032880]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005] cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027] ILAEDNLLWREK;LVCAVGSR;VVEEEQQQQLRQQEEEHTAR 3 5.7 0.94488 -0.62998 0 0 0 9.46087 0 9.43561 0 0 0 0 0 0 Q969H0 FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; lipid homeostasis [GO:0055088]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein localization [GO:0032880]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005] cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027] ILAEDNLLWREK;LVCAVGSR;MIFYKMKR 3 4.5 0.97502 -3.2756 0 0 0 10.6971 9.05393 0 0 0 0 0 0 0 Q969H4 CNKR1_HUMAN Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) CNKSR1 CNK1 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674] DPQLNER;NRDPQLNERVHR 2 1.7 0.97968 -1.8415 0 0 0 0 0 0 10.8037 0 0 0 0 0 Q969H8 MYDGF_HUMAN Myeloid-derived growth factor (MYDGF) MYDGF C19orf10 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] ESDVPLKTEEFEVTK 1 8.7 0.93046 -0.48853 0 0 0 0 0 0 0 0 10.9348 0 0 0 Q969I6 S38A4_HUMAN Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) SLC38A4 ATA3 NAT3 SNAT4 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; L-alanine import across plasma membrane [GO:1904273]; neutral amino acid transport [GO:0015804] microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; neutral L-amino acid:sodium symporter activity [GO:0005295] LAVLVAVTLTVPIVLFPIR 1 3.5 0.6694 0.1689 0 0 0 0 0 5.73503 0 0 0 0 0 0 Q969J5 I22R2_HUMAN "Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)" IL22RA2 UNQ5793/PRO19598/PRO19822 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; negative regulation of inflammatory response [GO:0050728]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] interleukin-22 binding [GO:0042017]; interleukin-22 receptor activity [GO:0042018] TLAKYGQRQWK 1 4.2 0.8649 -0.090103 0 8.60318 0 0 0 0 0 0 0 0 0 0 Q969K4 ABTB1_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein) ABTB1 BPOZ PP2259 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] translation elongation factor activity [GO:0003746] LARLEDQCTEYMAKVIEK;LVEREDFVEAVK;SSPLALA 3 9.1 0.86956 -0.097976 0 0 0 0 0 0 0 0 10.6317 10.816 0 0 Q969L2 MAL2_HUMAN Protein MAL2 MAL2 Homo sapiens (Human) myelination [GO:0042552] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle membrane [GO:0030672] structural constituent of myelin sheath [GO:0019911] SAGGASVPPPPNPAVSFPPPR 1 11.9 0.0086768 1.042 0 8.42677 0 0 0 0 0 0 0 0 0 0 Q969L4 LSM10_HUMAN U7 snRNA-associated Sm-like protein LSm10 LSM10 Homo sapiens (Human) mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; RNA splicing [GO:0008380] Cajal body [GO:0015030]; cytoplasmic U snRNP body [GO:0071254]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; U7 snRNP [GO:0005683] histone pre-mRNA DCP binding [GO:0071208]; U7 snRNA binding [GO:0071209] IDNVDAFMNIR 1 8.9 0.91744 -0.35776 0 0 0 0 8.70449 0 0 0 0 0 0 0 Q969M2 CXA10_HUMAN Gap junction alpha-10 protein (Connexin-62) (Cx62) GJA10 CX62 Homo sapiens (Human) cell-cell signaling [GO:0007267]; detection of light stimulus involved in visual perception [GO:0050908]; gamete generation [GO:0007276]; synapse assembly [GO:0007416] connexin complex [GO:0005922]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243] SKTMWQIPQPR 1 2 0.9658 -1.2441 0 0 0 0 0 0 0 0 9.40495 0 0 0 Q969M7 UBE2F_HUMAN NEDD8-conjugating enzyme UBE2F (EC 2.3.2.34) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F) UBE2F NCE2 Homo sapiens (Human) post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788] LLVKEVAELEANLPCTCK 1 9.7 0.9802 -1.5542 0 0 0 0 0 0 9.53275 0 0 0 0 0 Q969N4 TAAR8_HUMAN Trace amine-associated receptor 8 (TaR-8) (Trace amine receptor 8) (G-protein coupled receptor 102) (Trace amine receptor 5) (TaR-5) TAAR8 GPR102 TA5 TAR5 TRAR5 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] IFLIAKQQAIKIETTSSK 1 5.3 0.51713 0.18745 0 0 0 0 0 0 0 0 10.156 0 0 0 Q969P0 IGSF8_HUMAN Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316) IGSF8 CD81P3 EWI2 KCT4 Homo sapiens (Human) cell motility [GO:0048870]; nervous system development [GO:0007399]; positive regulation of cell migration [GO:0030335]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519] extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] signaling receptor activity [GO:0038023] LAAGELR 1 1.1 0.90925 -0.3099 0 0 0 0 0 0 0 0 0 0 0 9.44731 Q969P5 FBX32_HUMAN F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx) FBXO32 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018] SPGQNWVK;TQYFHQEK;VLEDQQNIR 3 7 0.9801 -1.5619 0 0 12.0409 0 0 0 0 8.82254 0 0 0 0 Q969P6 TOP1M_HUMAN "DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)" TOP1MT Homo sapiens (Human) DNA replication [GO:0006260]; DNA topological change [GO:0006265] chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]" AEDSIAAKILSYNR;AVALYFIDK;LALRAGNEK;LRAALTLLGEVPRRPASR;LTTTSLNK;VVAILCNHQRATPSTFEK 6 12.6 0.95851 -1.0025 4.07963 0 0 0 0 9.92676 9.49267 0 8.87738 5.63729 0 0 Q969Q0 RL36L_HUMAN Ribosomal protein eL42-like (60S ribosomal protein L36a-like) (Large ribosomal subunit protein eL42-like) RPL36AL Homo sapiens (Human) translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886] structural constituent of ribosome [GO:0003735] DSLYAQGR;KGQVIQF 2 14.2 0.91757 -0.35309 10.9103 11.6091 11.5565 0 0 0 0 0 0 0 0 0 Q969Q5 RAB24_HUMAN Ras-related protein Rab-24 RAB24 Homo sapiens (Human) autophagy [GO:0006914]; intracellular protein transport [GO:0006886] autophagosome [GO:0005776]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VMSVGDR 1 3.4 0.94035 -0.58376 0 0 0 0 0 0 0 0 7.80458 0 0 0 Q969Q6 P2R3C_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) PPP2R3C C14orf10 G5PR Homo sapiens (Human) B cell homeostasis [GO:0001782]; cortical cytoskeleton organization [GO:0030865]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of B cell differentiation [GO:0045579]; regulation of antimicrobial humoral response [GO:0002759]; regulation of dephosphorylation [GO:0035303]; regulation of mitochondrial depolarization [GO:0051900]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029] centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] HQTPPMIGEEAMINYENFLKVGEK;ISIMQFFNYVMRKVWLHQTR;LLDIENKGYLNVFSLNYFFR;LPAEDEVLLQKLR 4 17 0.95194 -0.75486 0 0 0 0 0 8.43442 6.87934 9.12358 0 0 9.91827 0 Q969R2 OSBP2_HUMAN Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) OSBP2 KIAA1664 ORP4 OSBPL4 Homo sapiens (Human) lipid transport [GO:0006869]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; apical dendrite [GO:0097440]; cytosol [GO:0005829]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485] ELSRIPMPVNFNEPLSMLQR;FLPYSYFSK;GRGCWDTASVR;VTGVVSDSQGK 4 7.7 0.97466 -2.3822 10.7057 0 12.3088 0 0 0 0 10.5933 11.4437 0 0 8.97722 Q969R5 LMBL2_HUMAN Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) L3MBTL2 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] AAPVSCFK;VGHGIKMSER 2 2.6 0.93839 -0.57358 0 11.7794 0 0 0 0 0 0 0 8.32634 0 0 Q969S2 NEIL2_HUMAN Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2) NEIL2 Homo sapiens (Human) depyrimidination [GO:0045008] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; microtubule binding [GO:0008017]; zinc ion binding [GO:0008270] RGDWRDPSPR;TGGSSKK 2 5.1 0.267 0.26641 0 0 10.6422 0 0 0 0 0 0 9.78434 0 0 Q969S3 ZN622_HUMAN Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) ZNF622 ZPR9 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273] "cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" preribosome binding [GO:1990275]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AQPSMSPK;VEMMNEKNLEK 2 4 0.84818 -0.076713 0 0 0 0 0 0 7.94661 9.61708 0 7.34926 0 0 Q969S6 TM203_HUMAN Transmembrane protein 203 TMEM203 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; spermatogenesis [GO:0007283] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; lysosomal membrane [GO:0005765] LAVLRLFWVLTVLSLK 1 11.8 0.81949 -0.01767 0 0 4.1157 0 0 4.25399 0 0 6.77466 0 0 0 Q969S9 RRF2M_HUMAN "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2)" GFM2 EFG2 MSTP027 Homo sapiens (Human) mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; ribosome disassembly [GO:0032790] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LKAKPLLLQLPIGEAKTFK 1 2.4 0.86394 -0.084404 0 0 0 0 0 0 4.41947 0 0 0 0 0 Q969T7 5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) NT5C3B NT5C3L Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleotide metabolic process [GO:0009117]" cytoplasm [GO:0005737]; cytosol [GO:0005829] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] IISEECRK 1 2.7 0.82532 -0.0197 0 0 12.0828 0 0 0 0 0 0 0 0 0 Q969U6 FBXW5_HUMAN F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) FBXW5 FBW5 PP3971 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] protein kinase binding [GO:0019901] VLQAPRPRPRTFFSWLASQR 1 3.5 0.81673 -0.01737 0 0 0 0 0 0 10.2896 0 0 0 0 0 Q969U7 PSMG2_HUMAN Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1) PSMG2 HCCA3 PAC2 TNFSF5IP1 Homo sapiens (Human) chaperone-mediated protein complex assembly [GO:0051131]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248] cytosol [GO:0005829]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] molecular adaptor activity [GO:0060090] LVALQLRSIFIK;YKSKPFCEKLLSWVK 2 10.2 0.97922 -1.8885 0 0 0 0 0 0 0 0 0 0 3.63749 0 Q969V3 NCLN_HUMAN BOS complex subunit NCLN (Nicalin) (Nicastrin-like protein) NCLN Homo sapiens (Human) determination of left/right asymmetry in lateral mesoderm [GO:0003140]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]; protein stabilization [GO:0050821]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; regulation of signal transduction [GO:0009966] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991] ribosome binding [GO:0043022] ADKRDPEFVFYDQLK 1 2.7 0.85259 -0.079794 0 0 0 0 0 0 0 0 0 9.54551 0 0 Q969V4 TEKT1_HUMAN Tektin-1 TEKT1 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] ADAQRSR;ILSQTANDLRK;SQSDVNK 3 6 0.98094 -1.6932 0 0 0 0 0 8.39124 0 0 0 8.56293 0 0 Q969V6 MRTFA_HUMAN Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) MRTFA KIAA1438 MAL MKL1 Homo sapiens (Human) "actin cytoskeleton organization [GO:0030036]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]; wound healing, spreading of cells [GO:0044319]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779]; actin monomer binding [GO:0003785]; leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713] AGSCCLSPGGR;DSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIK;LRSLPVSGTKTELIER;SLPVSGTKTELIERLR 4 7.5 0.79456 0.015861 0 0 8.00141 0 0 0 0 0 0 0 0 10.2984 Q969W1 ZDH16_HUMAN Palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Abl-philin 2) (Zinc finger DHHC domain-containing protein 16) (DHHC-16) ZDHHC16 APH2 UNQ2570/PRO6258 Homo sapiens (Human) apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment [GO:0021899]; heart development [GO:0007507]; protein palmitoylation [GO:0018345]; telencephalon development [GO:0021537] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] MDHHCPWLNNCVGHYNHR;SLVYLWFLCSSVALALGALTVWHAVLISRGETSIERHINK 2 15.4 0.94072 -0.58582 0 0 0 0 0 0 0 0 0 0 10.136 0 Q969W3 VCF1_HUMAN Protein VCF1 (VCP nuclear cofactor family member 1) VCF1 FAM104A Homo sapiens (Human) EAHFHSLQHR 1 5.4 0.80277 0.014246 0 0 0 0 0 0 8.02098 0 0 0 0 0 Q969X0 RIPL2_HUMAN RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein) RILPL2 RLP2 Homo sapiens (Human) cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] EEEEEEGEEDEER;ELMALGSDPRVTQLQFK;SGLIPPR;TIIKKLFFFR;VTQLQFK 5 22.3 0.96702 -1.3105 0 0 6.76739 0 0 5.626 0 5.73311 4.00054 0 3.78188 0 Q969X2 SIA7F_HUMAN "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F)" ST6GALNAC6 SIAT7F UNQ708/PRO1359 Homo sapiens (Human) cell-cell recognition [GO:0009988]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid biosynthetic process [GO:0006688]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]" MQKPQGSLVRVIQR 1 4.2 0.98079 -1.6231 0 0 0 0 0 0 9.30159 0 0 0 0 0 Q969X6 UTP4_HUMAN U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) UTP4 CIRH1A cPERP-E KIAA1988 Homo sapiens (Human) "maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]" 90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] RNA binding [GO:0003723] LNYEHDNISLKRVSK;QYTDWSRTVQK;RPMHILLHDAYMFCIIDK;RQLLLFQFAHHLELWRLGSTVATGK 4 10.1 0.83277 -0.029254 0 7.42618 0 0 0 0 11.0682 0 0 0 10.2007 0 Q969Y0 NXPE3_HUMAN NXPE family member 3 (Protein FAM55C) NXPE3 FAM55C MSTP115 UNQ5791/PRO19596 Homo sapiens (Human) extracellular region [GO:0005576] LQEDKPDRVYFK 1 2.1 0.92427 -0.44861 0 0 12.1845 0 0 0 0 0 0 0 0 0 Q969Z0 FAKD4_HUMAN FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) TBRG4 CPR2 FASTKD4 KIAA0948 Homo sapiens (Human) mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] GAYLKDKMR;KVTPLQK 2 2.5 0.9587 -1.0071 0 0 0 0 0 0 0 9.88087 0 0 0 0 Q969Z3 MARC2_HUMAN Mitochondrial amidoxime reducing component 2 (mARC2) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) (MOSC domain-containing protein 2) (Moco sulfurase C-terminal domain-containing protein 2) MTARC2 MARC2 MOSC2 Homo sapiens (Human) cellular detoxification of nitrogen compound [GO:0070458]; detoxification of nitrogen compound [GO:0051410]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] "molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]" LCDPSERELYK;LQQVGTVAK 2 6 0.94446 -0.64651 0 0 0 0 0 9.62979 0 0 0 0 0 0 Q969Z4 TR19L_HUMAN Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues) RELT TNFRSF19L Homo sapiens (Human) amelogenesis [GO:0097186]; apoptotic process [GO:0006915] nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LITEKKENAAALEELLK;RLEAQVGMATR 2 6.5 0.98096 -1.7998 0 0 10.2688 8.49713 0 0 0 0 0 0 0 0 Q96A00 PP14A_HUMAN Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) PPP1R14A CPI17 PPP1INL Homo sapiens (Human) cytosol [GO:0005829] protein serine/threonine phosphatase inhibitor activity [GO:0004865] AAQRLGK 1 4.8 0.96732 -1.309 0 0 0 0 0 0 0 0 0 0 0 10.484 Q96A04 TSACC_HUMAN TSSK6-activating co-chaperone protein (SSTK-interacting protein) (SIP) (SSTK-IP) TSACC C1orf182 Homo sapiens (Human) cytoplasm [GO:0005737] protein-folding chaperone binding [GO:0051087] ERHTSHPNRK 1 8 0.8657 -0.092362 0 0 0 0 0 0 0 7.66363 0 0 0 0 Q96A05 VATE2_HUMAN V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2) ATP6V1E2 ATP6E1 ATP6EL2 ATP6V1EL2 Homo sapiens (Human) regulation of macroautophagy [GO:0016241] "acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LLEPVMIVR;MPEIRMALFGANTNRK 2 11.1 0.95243 -0.74371 4.04089 0 0 0 0 0 0 0 0 8.25772 8.23501 0 Q96A09 TET5B_HUMAN Terminal nucleotidyltransferase 5B (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46B) TENT5B FAM46B Homo sapiens (Human) mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of translation [GO:0045727] cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) RNA polymerase activity [GO:1990817] AVVLACLLDFLPAGVSRAKITPLTLK;ITPLTLK 2 6.1 0.19028 0.33631 0 0 0 0 0 0 0 0 0 0 8.56377 0 Q96A19 C102A_HUMAN Coiled-coil domain-containing protein 102A CCDC102A Homo sapiens (Human) myosin complex [GO:0016459] QRLDALTKELAGAR 1 2.5 0.86589 -0.088319 0 0 0 0 0 0 0 0 0 0 6.35046 0 Q96A23 CPNE4_HUMAN Copine-4 (Copine IV) (Copine-8) CPNE4 Homo sapiens (Human) cellular response to calcium ion [GO:0071277] extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] LFTVDFYFEEVQR;QVQWECINPK;VAKSASEETNTK 3 6.3 0.96102 -1.0576 0 0 0 0 0 0 0 0 0 0 9.91058 0 Q96A28 SLAF9_HUMAN SLAM family member 9 (CD2 family member 10) (CD2F-10) (CD84 homolog 1) (CD84-H1) SLAMF9 CD2F10 UNQ1938/PRO4421 Homo sapiens (Human) immune response [GO:0006955]; T cell activation [GO:0042110] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897] GLLIFLLLVILAMGLWVIR;GLLIFLLLVILAMGLWVIRVQK 2 11.1 0.90645 -0.2729 0 0 0 0 5.99971 0 0 0 0 0 0 0 Q96A29 FUCT1_HUMAN GDP-fucose transporter 1 (Solute carrier family 35 member C1) SLC35C1 FUCT1 Homo sapiens (Human) GDP-fucose import into Golgi lumen [GO:0036085]; GDP-L-fucose biosynthetic process [GO:0042350]; lipid glycosylation [GO:0030259]; negative regulation of Notch signaling pathway [GO:0045746]; protein O-linked fucosylation [GO:0036066] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457] KTPEEPSPKDSEK 1 3.6 0.95868 -1.0057 0 0 0 0 0 0 0 0 0 0 0 10.6938 Q96A32 MYL11_HUMAN "Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform)" MYL11 HSRLC MYLPF Homo sapiens (Human) actin-myosin filament sliding [GO:0033275]; immune response [GO:0006955]; muscle contraction [GO:0006936]; muscle tissue morphogenesis [GO:0060415]; skeletal muscle tissue development [GO:0007519] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; muscle myosin complex [GO:0005859] calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307] LKGADPEDVITGAFK;VLDPEGK 2 13 0.96573 -1.1269 0 0 0 0 0 0 8.62158 0 0 0 11.0294 0 Q96A33 CCD47_HUMAN PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47) CCDC47 GK001 MSTP041 PSEC0077 Homo sapiens (Human) endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791]; protein insertion into ER membrane [GO:0045048] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; rough endoplasmic reticulum membrane [GO:0030867] calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] QTYHWGK 1 1.5 0.91195 -0.32293 0 0 0 5.77046 0 0 0 0 0 0 0 0 Q96A35 RM24_HUMAN "Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24)" MRPL24 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LVDPMDR 1 3.2 0.90963 -0.31529 0 0 0 0 0 0 0 0 9.28965 0 0 0 Q96A44 SPSB4_HUMAN SPRY domain-containing SOCS box protein 4 (SSB-4) SPSB4 SSB4 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GKVGHAR;LSGSLKSVEVR 2 6.6 0.92879 -0.46301 0 0 0 0 6.37806 0 0 0 0 0 0 0 Q96A46 MFRN2_HUMAN Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28) SLC25A28 MFRN2 NPD016 Homo sapiens (Human) iron import into the mitochondrion [GO:0048250] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ferrous iron transmembrane transporter activity [GO:0015093] GVQARVIYQIPSTAIAWSVYEFFK 1 6.6 0.8356 -0.034544 0 0 9.12663 0 0 0 11.4544 0 0 0 0 0 Q96A47 ISL2_HUMAN Insulin gene enhancer protein ISL-2 (Islet-2) ISL2 Homo sapiens (Human) axonogenesis [GO:0007409]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord motor neuron cell fate specification [GO:0021520]; visceral motor neuron differentiation [GO:0021524] chromatin [GO:0000785]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]" QLLPGDEFSLREHELLCR;VWFQNKR 2 7 0.91969 -0.43797 0 0 0 0 0 0 0 0 0 8.03227 0 0 Q96A49 SYAP1_HUMAN Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) SYAP1 PRO3113 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; TORC2 signaling [GO:0038203] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] IDGIIDKTIIGDFQKEQK 1 5.1 0.44383 0.19291 0 0 0 0 0 0 0 0 0 0 11.1804 0 Q96A56 T53I1_HUMAN Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) TP53INP1 P53DINP1 SIP Homo sapiens (Human) apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; response to heat [GO:0009408] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] antioxidant activity [GO:0016209] RQNLTRDCHPR 1 4.6 0.76754 0.059657 0 0 0 8.8627 0 0 0 0 0 0 0 0 Q96A57 TM230_HUMAN Transmembrane protein 230 TMEM230 C20orf30 HSPC274 UNQ2432/PRO4992 Homo sapiens (Human) axonal transport [GO:0098930]; synaptic vesicle transport [GO:0048489] autophagosome [GO:0005776]; axon [GO:0030424]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] IAYYASKGYR;TPPKIPYK;TPPKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISK 3 39.2 0.96384 -1.1811 0 0 0 0 10.1721 0 0 8.59865 0 5.82525 0 0 Q96A59 MALD3_HUMAN MARVEL domain-containing protein 3 MARVELD3 MRVLDC3 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; protein localization to cell junction [GO:1902414]; protein ubiquitination [GO:0016567]; response to osmotic stress [GO:0006970]; ubiquitin-dependent protein catabolic process [GO:0006511] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; nucleus [GO:0005634] mitogen-activated protein kinase kinase kinase binding [GO:0031435]; ubiquitin protein ligase activity [GO:0061630] DPGRRPHPDQGR;DTHRDAGPRAGEHGVWEKPR;RPHPDQGR 3 8 0.94091 -0.5866 0 0 0 0 0 0 0 9.27438 9.93345 0 0 0 Q96A65 EXOC4_HUMAN Exocyst complex component 4 (Exocyst complex component Sec8) EXOC4 KIAA1699 SEC8 SEC8L1 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; paraxial mesoderm formation [GO:0048341]; protein transmembrane transport [GO:0071806]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; synapse [GO:0045202] PDZ domain binding [GO:0030165] ENLLSCKMLLHCK;LNKDISAIEEAMSASLQQHK;MCRNIFVLQQNLTNITMSR;VLGVQRPLLQSTIIVEK 4 7.1 0.95328 -0.72773 0 9.0052 3.03067 0 8.76288 6.65292 0 8.50716 0 0 6.71411 0 Q96A72 MGN2_HUMAN Protein mago nashi homolog 2 MAGOHB MAGOH2 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] AVASDFYLR;IGSLIDVNQSK;VFYYLVQDLK;YANNSNYK 4 25.7 0 1.8603 3.76702 0 0 0 0 0 0 0 0 0 8.58154 0 Q96A73 P33MX_HUMAN Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) KIAA1191 P33MONOX Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] GAQKPSPLELIRAQANR;GLTTEETK 2 8.2 0.91797 -0.40833 0 0 0 0 0 0 0 0 0 8.21558 7.36501 0 Q96A83 COQA1_HUMAN Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2) COL26A1 EMID2 EMU2 Homo sapiens (Human) positive regulation of cell-substrate adhesion [GO:0010811] collagen type XXVI trimer [GO:1990324]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] CCPGFTGSNCDEECMNCTR;LSDMSER 2 5.9 0.87963 -0.14567 0 0 3.78167 0 0 0 0 0 0 0 0 9.09729 Q96A84 EMID1_HUMAN EMI domain-containing protein 1 (Emilin and multimerin domain-containing protein 1) (Emu1) EMID1 EMU1 Homo sapiens (Human) collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] GISGHPGEKGERGLR;TVVRPTYKVMYK;VSELTER 3 7.7 0.97927 -1.5407 0 0 0 0 0 0 0 0 0 0 11.6466 0 Q96A98 TIP39_HUMAN Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2) PTH2 TIP39 TIPF39 Homo sapiens (Human) neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] AWADPATPRPRR;LLAALER;LLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGR 3 55 0.95124 -0.6961 0 0 9.36019 0 0 0 0 0 10.6748 0 0 8.26411 Q96A99 PTX4_HUMAN Pentraxin-4 PTX4 C16orf38 Homo sapiens (Human) extracellular region [GO:0005576] metal ion binding [GO:0046872] SQASVQGELAQLK 1 2.7 0.89715 -0.23595 0 0 0 0 8.35984 8.23874 0 10.4873 10.5449 0 0 0 Q96AA3 RFT1_HUMAN Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (Protein RFT1 homolog) RFT1 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glycolipid translocation [GO:0034203]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] glycolipid floppase activity [GO:0034202] TQLGVPRRTDK;VIAESLSVILK 2 4.1 0.91201 -0.32309 0 0 0 6.67864 0 0 0 0 0 0 9.7354 0 Q96AA8 JKIP2_HUMAN Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1) JAKMIP2 JAMIP2 KIAA0555 NECC1 Homo sapiens (Human) Golgi apparatus [GO:0005794] kinase binding [GO:0019900]; microtubule binding [GO:0008017] DLEDKTDIQKR;EKITSHPPLK;LEREKTQEAK 3 3.8 0.97512 -4.0017 0 0 0 0 0 0 0 0 9.91931 10.5823 0 11.4642 Q96AC1 FERM2_HUMAN Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) FERMT2 KIND2 MIG2 PLEKHC1 Homo sapiens (Human) "adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]" adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713]" DTSISCYK;FSNMKQWNVNWEIK;LDVKKDWSDHALWWEK;LTLKGYKQYWCTFK;TWRFSNMK 5 8.1 0.98026 -1.827 0 0 9.00031 0 0 0 0 0 8.32939 8.47703 0 0 Q96AC6 KIFC2_HUMAN Kinesin-like protein KIFC2 KIFC2 Homo sapiens (Human) microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] QHRVTLSMVEIYNEAVR 1 2 0.94499 -0.64966 0 0 0 0 0 9.13958 0 0 0 0 0 0 Q96AE4 FUBP1_HUMAN Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) FUBP1 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] IGGNEGIDVPIPR;IQIAPDSGGLPER;IQNDAGVR;ITGDPYK;ITGDPYKVQQAK;LLDQIVEK;SISQQSGAR 7 9.8 0.0024752 1.6662 11.1988 0 0 0 0 7.72826 9.15755 10.4117 12.8126 8.35795 10.97 0 Q96AE7 TTC17_HUMAN Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ALHFSSR;EDPIFTYLSKRLGR;ELEVRMDLK;EYQKQHDHYLR;ILELPYSIHAFQHLR;NISGALEAFR;QEATVNYLKELEK;SSCYGDCR;TLDNSHDKQK 9 10.1 0.97414 -2.4581 7.37556 7.60777 11.7203 0 11.3611 11.4022 11.1654 0 8.70757 0 0 0 Q96AG3 S2546_HUMAN Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) SLC25A46 TB1 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; cerebellar Purkinje cell differentiation [GO:0021702]; cristae formation [GO:0042407]; dendrite development [GO:0016358]; establishment of localization in cell [GO:0051649]; locomotion involved in locomotory behavior [GO:0031987]; mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; mitochondrial transport [GO:0006839]; myelination in peripheral nervous system [GO:0022011]; optic nerve development [GO:0021554]; peripheral nervous system neuron axonogenesis [GO:0048936]; phospholipid homeostasis [GO:0055091]; protein-containing complex assembly [GO:0065003]; respiratory chain complex IV assembly [GO:0008535]; synapse assembly [GO:0007416] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein-containing complex binding [GO:0044877] FVLLILKRK;VIGMGVPHSK;YSFNKTQGPR 3 10.7 0.91567 -0.39147 0 6.70833 0 0 0 3.65947 10.2943 0 0 0 9.41373 0 Q96AG4 LRC59_HUMAN "Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]" LRRC59 PRO1855 Homo sapiens (Human) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; nuclear envelope [GO:0005635] cadherin binding [GO:0045296]; protein serine/threonine phosphatase activity [GO:0004722]; RNA binding [GO:0003723] ELAALPK;LQQLPADFGR;VLQHMKAVQADQER 3 10.1 0.95465 -0.94788 7.19594 0 13.1462 9.57569 0 0 0 0 0 0 10.393 0 Q96AH0 SOSB2_HUMAN SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) NABP1 OBFC2A SSB2 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]" DNA binding [GO:0003677]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] NLNVVFIVLEIGRVTKTK 1 13.4 0.54692 0.1835 0 0 0 0 0 0 0 3.5409 0 0 0 0 Q96AH8 RAB7B_HUMAN Ras-related protein Rab-7b RAB7B Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; endosome to lysosome transport [GO:0008333]; late endosome to Golgi transport [GO:0034499]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; phagosome-lysosome fusion [GO:0090385]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein transport [GO:0015031] Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DIPYFEVSAK;KVDLKLIIVGAIGVGK 2 13.1 0.94436 -0.64676 0 0 0 0 4.8165 9.60655 0 0 0 0 0 0 Q96AJ1 CLUA1_HUMAN Clusterin-associated protein 1 (Qilin) CLUAP1 KIAA0643 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654] HISMENFR;ITSVLYNAMKTK;SGSNDDSDIDIQEDDESDSELEER;TKDLLNNVASDEANLEAK 4 15 0.96629 -1.2703 0 3.77579 10.7722 0 0 0 0 0 0 0 6.82413 9.97528 Q96AJ9 VTI1A_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) VTI1A Homo sapiens (Human) "autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]" autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] ILLVILGIIVVITILMAITFSVR;ILLVILGIIVVITILMAITFSVRR;SRIAYSDEVR;SSRILTGMLR 4 20.3 0.97582 -2.3478 0 0 0 0 6.60133 0 7.68215 0 0 0 0 0 Q96AN5 TM143_HUMAN Transmembrane protein 143 TMEM143 UNQ5922/PRO19813 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] GVWGSRVR;VGQMPLK 2 3.3 0.96395 -1.1833 0 0 0 0 0 0 0 0 0 0 12.4971 0 Q96AP4 ZUP1_HUMAN Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein) ZUP1 C6orf113 ZUFSP Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872] GWGCGYR 1 1.2 0.69107 0.16248 0 0 0 0 4.74497 0 0 0 0 0 0 0 Q96AQ1 CC74A_HUMAN Coiled-coil domain-containing protein 74A CCDC74A Homo sapiens (Human) SGAGVAAGTRPPSSPTPGSR 1 5.3 0.87334 -0.10794 0 0 0 0 0 0 0 0 0 8.84244 0 0 Q96AQ2 TM125_HUMAN Transmembrane protein 125 TMEM125 Homo sapiens (Human) membrane [GO:0016020] LATGTVLCLLALLVLVK 1 7.8 0.7841 0.020246 0 0 0 0 4.56157 0 0 0 0 0 0 0 Q96AQ6 PBIP1_HUMAN Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) PBXIP1 HPIP Homo sapiens (Human) articular cartilage development [GO:0061975]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; extracellular matrix disassembly [GO:0022617]; gene expression involved in extracellular matrix organization [GO:1901148]; hemopoiesis [GO:0030097]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of Wnt signaling pathway [GO:0030177]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor binding [GO:0140297]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] KKNWGGQEDR;LQGLEADCVR;VEESGSKKEGK 3 4.2 0.9739 -3.0169 0 0 0 0 0 0 0 0 0 0 0 10.1739 Q96AQ8 MCUR1_HUMAN "Mitochondrial calcium uniporter regulator 1 (MCU regulator 1) (Coiled-coil domain-containing protein 90A, mitochondrial)" MCUR1 C6orf79 CCDC90A Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] GGVSRASPLLLLLLVPSPR 1 5.3 0.91921 -0.43801 0 0 0 0 8.42425 0 0 0 0 0 0 0 Q96AV8 E2F7_HUMAN Transcription factor E2F7 (E2F-7) E2F7 Homo sapiens (Human) "chorionic trophoblast cell differentiation [GO:0060718]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokinesis [GO:0032466]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707]" chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ILIEESQDAPDHSK;LYDIANVLTSLALIKK 2 3.3 0.41206 0.20478 0 0 12.263 0 0 0 9.97671 0 0 0 0 0 Q96AW1 VOPP1_HUMAN "WW domain binding protein VOPP1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N) (Vesicular, overexpressed in cancer, prosurvival protein 1)" VOPP1 ECOP GASP Homo sapiens (Human) cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090] enzyme binding [GO:0019899] SYEDCCGSRCCVR 1 7.6 0.83709 -0.033172 0 0 0 0 0 0 0 0 0 5.19389 0 0 Q96AX1 VP33A_HUMAN Vacuolar protein sorting-associated protein 33A (hVPS33A) VPS33A Homo sapiens (Human) autophagosome maturation [GO:0097352]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] QVANMMIRMK;VNNYIEDCIAQK 2 3.7 0.96733 -1.3155 0 0 0 0 0 0 9.21759 0 0 0 0 0 Q96AX9 MIB2_HUMAN E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) MIB2 SKD ZZANK1 Homo sapiens (Human) Notch signaling pathway [GO:0007219]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein ubiquitination [GO:0016567]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CIRCQVVVSK;GIFQGAK;TVCEECARRMK;TVVVQWDQGTRTNYR 4 4.5 0.97325 -2.6499 0 0 0 8.99265 8.36479 0 0 0 0 12.1332 9.7271 0 Q96AY2 EME1_HUMAN Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4) EME1 MMS4 Homo sapiens (Human) double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429] endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] ETLQGFVTDITAK;IGPELSRR 2 3.7 0.88105 -0.17009 12.9053 0 0 0 8.99879 0 10.1123 9.70684 11.7163 13.4822 0 10.259 Q96AY3 FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) FKBP10 FKBP65 PSEC0056 Homo sapiens (Human) aorta morphogenesis [GO:0035909]; collagen fibril organization [GO:0030199]; extracellular matrix assembly [GO:0085029]; in utero embryonic development [GO:0001701]; protein folding [GO:0006457]; wound healing [GO:0042060] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758] calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] GMDQGLLGMCPGERR;IIIPPFLAYGEK;NTLVAIVVGVGRLITGMDR 3 7.9 0.83913 -0.038973 0 4.26258 0 0 3.73942 0 0 0 0 0 0 7.85481 Q96AY4 TTC28_HUMAN Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) cell division [GO:0051301]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle pole [GO:0000922] kinase binding [GO:0019900] ACASSETESEAGDIMDQQFEEMNNK;ASAALGEAMK;DINGAIKFYEQQLGLAHQVKDR;GLGNGHR;LLNPKWPK;SAAYMKIQQYDK 6 3.4 0.97833 -2.1287 8.41414 0 0 0 0 0 0 11.6714 0 0 8.12304 0 Q96AZ6 ISG20_HUMAN Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20) ISG20 HEM45 Homo sapiens (Human) defense response to virus [GO:0051607]; DNA catabolic process [GO:0006308]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605] 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U3 snoRNA binding [GO:0034511] GLPRLAVSD 1 5 0.96633 -1.2838 0 0 0 9.04887 0 0 0 8.20643 0 0 0 0 Q96B01 R51A1_HUMAN RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) RAD51AP1 PIR51 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of double-strand break repair via homologous recombination [GO:0010569] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" D-loop DNA binding [GO:0062037]; DNA binding [GO:0003677]; DNA secondary structure binding [GO:0000217]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] ELPTVTTNVQNSQDK;KPLEIRSPSAESKKPK;SIEKHGSSK;VSLSSDTTR 4 13.9 0.97903 -1.9154 0 0 0 0 4.47028 0 0 12.7331 0 0 0 10.6837 Q96B33 CLD23_HUMAN Claudin-23 CLDN23 Homo sapiens (Human) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] GPSAGPR;KGPSAGPR;KPKPKPKVGFPMPRPRPK 3 8.9 0.95185 -0.68551 0 0 0 0 0 0 10.39 10.0651 0 8.1069 0 0 Q96B70 LENG9_HUMAN Leukocyte receptor cluster member 9 LENG9 Homo sapiens (Human) metal ion binding [GO:0046872] FHGRLVWDR;VPHGSQVHLPK 2 4 0.97987 -1.5396 0 0 0 9.74861 0 8.55781 0 0 0 0 0 0 Q96B86 RGMA_HUMAN Repulsive guidance molecule A (RGM domain family member A) RGMA RGM Homo sapiens (Human) BMP signaling pathway [GO:0030509]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; neural tube closure [GO:0001843]; neuron projection development [GO:0031175]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] coreceptor activity [GO:0015026]; transferrin receptor binding [GO:1990459] MGGLGPR;TRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC 2 9 0.13517 0.35561 0 0 0 0 0 0 0 0 8.36505 4.43149 0 0 Q96B97 SH3K1_HUMAN SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) SH3KBP1 CIN85 Homo sapiens (Human) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of B cell activation [GO:0050871]; regulation of cell shape [GO:0008360] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625] ETTGSESDGGDSSSTK;GVGFGDIFK;QLLSELDEEKK;SIEVENDFLPVEK;TGMFPSNFIK;VIFPYEAQNDDELTIK 6 11.3 0.91757 -0.42468 15.4455 15.0608 14.9236 13.743 7.70217 13.37 14.749 15.0235 14.9198 13.3483 13.1145 15.5433 Q96BA8 CR3L1_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] CREB3L1 OASIS PSEC0238 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix constituent secretion [GO:0070278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of sprouting angiogenesis [GO:1903671]; osteoblast differentiation [GO:0001649]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]" DAVLEPFPADR;KVETFTSENNELWK;TLLQQLQKLQTLVTNK 3 7.9 0.84222 -0.052031 10.8528 9.02937 0 5.95692 0 0 0 0 8.93593 0 0 0 Q96BD5 PF21A_HUMAN PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) PHF21A BHC80 KIAA1696 BM-006 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] GMWICPRCQDQMLKK;MELQTLQEALKVEIQVHQK;QEREQLEQK;TIPKGMWICPR;TVTTASMITTK 5 8.5 0.97257 -2.7657 0 0 8.39601 0 0 7.69579 7.48285 0 0 7.05961 9.27396 0 Q96BD6 SPSB1_HUMAN SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 SSB1 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GLHVWQITWAMR;TVDMRDPTYRPLK 2 9.2 0.95724 -0.84822 0 0 0 8.74184 8.95379 0 0 9.42362 0 0 0 0 Q96BD8 SKA1_HUMAN SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) SKA1 C18orf24 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of meiotic spindle orientation [GO:0051296]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of mitotic spindle assembly checkpoint signaling [GO:0140499]; positive regulation of microtubule polymerization [GO:0031116]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly involved in female meiosis [GO:0007056] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; outer kinetochore [GO:0000940]; SKA complex [GO:0170027]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] FHVLLNILRHCR 1 4.7 0.92468 -0.45072 0 0 12.015 0 0 0 0 0 0 0 0 0 Q96BF6 NACC2_HUMAN Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain) NACC2 BTBD14A NAC2 RBB Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; protein homooligomerization [GO:0051260]; protein-containing complex localization [GO:0031503]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLFSGNSK;GTDLMFK 2 2.6 0.92963 -0.48565 0 0 8.93934 8.9646 9.45177 9.19247 9.90836 9.74636 9.54427 0 0 0 Q96BH3 ESPB1_HUMAN Epididymal sperm-binding protein 1 (Epididymal secretory protein 12) (hE12) ELSPBP1 E12 Homo sapiens (Human) single fertilization [GO:0007338]; sperm capacitation [GO:0048240] cell surface [GO:0009986]; extracellular region [GO:0005576] heparin binding [GO:0008201] NYFNCTNEGSK 1 4.9 0.80828 0.010964 0 0 0 0 0 0 0 5.21692 0 0 0 0 Q96BI1 S22AI_HUMAN Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A) SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] symporter activity [GO:0015293]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910] AIASLLR 1 1.7 0.92754 -0.45807 0 0 0 0 0 0 0 11.962 0 0 0 0 Q96BJ3 AIDA_HUMAN "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" AIDA C1orf80 Homo sapiens (Human) determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333] cytoplasm [GO:0005737]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904] KTIGKIATCLELR;LTKGAAIFFEFK 2 8.2 0.86939 -0.094088 0 0 0 0 0 0 0 0 0 0 0 5.25267 Q96BJ3 AIDA_HUMAN "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" AIDA C1orf80 Homo sapiens (Human) determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333] cytoplasm [GO:0005737]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904] LTKGAAIFFEFK;TLLTIRIEKIGLK 2 17.7 0.91557 -0.39277 0 0 0 8.43958 0 0 0 4.50564 0 0 0 0 Q96BJ8 ELMO3_HUMAN Engulfment and cell motility protein 3 ELMO3 Homo sapiens (Human) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis [GO:0006909] cytoplasm [GO:0005737] SH3 domain binding [GO:0017124] IFAREVISR;RQDKLWFCCLSPNHK 2 4 0.84884 -0.071203 0 0 0 0 0 0 0 7.99927 0 10.1885 0 0 Q96BK5 PINX1_HUMAN PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) PINX1 LPTL LPTS Homo sapiens (Human) "mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; telomere maintenance via telomerase [GO:0007004]" "chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]" protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034] SFSLEEK 1 2.1 0.93597 -0.5463 0 0 0 0 0 0 0 0 0 9.29772 0 0 Q96BM1 ANKR9_HUMAN Ankyrin repeat domain-containing protein 9 ANKRD9 Homo sapiens (Human) intracellular copper ion homeostasis [GO:0006878]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ASEAFHWDERGR 1 3.8 0.9239 -0.45001 0 0 3.34554 0 0 0 0 0 0 0 0 0 Q96BP2 CHCH1_HUMAN "Small ribosomal subunit protein mS37 (28S ribosomal protein S37, mitochondrial) (MRP-S37) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 1) (Nuclear protein C2360)" CHCHD1 C10orf34 MRPS37 Homo sapiens (Human) mitochondrial translation [GO:0032543] cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] EIQGFLDCAARAQEAR;KPVLKPNKPLILANRVGER 2 29.7 0.95557 -0.86884 0 0 0 0 0 0 0 0 2.99641 4.38778 9.51877 0 Q96BP3 PPWD1_HUMAN Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) PPWD1 KIAA0073 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] AYPTSVCFSPDGK;KNRFYMFTK;TDFIITASHDGHVK 3 5.6 0.96175 -1.075 11.2802 11.2945 0 8.52191 0 0 0 0 0 0 0 0 Q96BQ1 FAM3D_HUMAN Protein FAM3D FAM3D UNQ567/PRO1130 Homo sapiens (Human) negative regulation of insulin secretion [GO:0046676] extracellular region [GO:0005576]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125] KLFSDLGSSYAKQLGFR;LFSDLGSSYAK 2 7.6 0.9519 -0.71128 0 0 0 0 0 0 0 10.5102 0 0 0 0 Q96BQ3 TRI43_HUMAN Tripartite motif-containing protein 43 TRIM43 Homo sapiens (Human) innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] centrosome [GO:0005813]; cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ASLWQFLSSEKQICGTHR;MDFKTNILLKNLVTIAR;QTKKMFCDMDK;TAFLWRGNVVLRAQMIR 4 14.1 0.88097 -0.15171 0 0 6.40966 0 0 8.89591 0 10.4213 0 0 0 7.94854 Q96BQ5 CC127_HUMAN Coiled-coil domain-containing protein 127 CCDC127 Homo sapiens (Human) mitochondrion [GO:0005739] AVAQLSLELEK;YWELVVELK 2 7.7 0.84073 -0.041448 0 0 0 0 0 0 0 0 0 0 7.84317 0 Q96BR6 ZN669_HUMAN Zinc finger protein 669 ZNF669 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KCGKAYTR;YHGSIHTGERPYECKQCGK 2 5.8 0.96609 -1.2846 0 0 0 0 0 0 0 11.2429 0 0 0 0 Q96BS2 CHP3_HUMAN Calcineurin B homologous protein 3 (Tescalcin) (TSC) TESC CHP3 Homo sapiens (Human) cell differentiation [GO:0030154]; cellular response to retinoic acid [GO:0071300]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of cell adhesion mediated by integrin [GO:0033628] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphatase inhibitor activity [GO:0019212]; protein homodimerization activity [GO:0042803]; protein kinase inhibitor activity [GO:0004860] ITLEEYR;NVKWSRSCCR;TGFSSDQIEQLHRR 3 19 0.91347 -0.38732 0 0 0 0 8.20472 0 4.29028 0 11.6363 8.80339 0 0 Q96BT3 CENPT_HUMAN Centromere protein T (CENP-T) (Interphase centromere complex protein 22) CENPT C16orf56 ICEN22 Homo sapiens (Human) cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] AASPESASSTPESLQAR;ADHNPDSDSTPRTLLR;ALEMVEK;AVDVGAFLR 4 8.7 0.97407 -1.4019 0 7.79571 0 0 0 0 0 0 0 0 8.70269 10.3401 Q96BT7 ALKB8_HUMAN tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 (EC 2.1.1.229) (Alkylated DNA repair protein alkB homolog 8) (Alpha-ketoglutarate-dependent dioxygenase ALKBH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8) ALKBH8 ABH8 Homo sapiens (Human) DNA damage response [GO:0006974]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA (uridine) methyltransferase activity [GO:0016300]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] SLLVMTGESR;SQNLVDICRER 2 3.2 0.98114 -2.0303 0 0 0 0 0 0 12.0044 0 0 13.1214 0 0 Q96BU1 S1PBP_HUMAN S100P-binding protein (S100P-binding protein Riken) S100PBP S100PBPR Homo sapiens (Human) cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] calcium-dependent protein binding [GO:0048306] DETDSSK;LSSLGEEMR 2 3.9 0.94472 -0.62513 9.13414 0 0 0 5.17501 0 0 0 0 0 0 0 Q96BV0 ZN775_HUMAN Zinc finger protein 775 ZNF775 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] FSWWSSLKIHQRTHTGEKPYLCGK;HHTGERPFCCPECARR 2 7.4 0.13709 0.35412 5.51238 0 0 0 0 0 0 0 0 6.27303 0 0 Q96BW1 UPP_HUMAN Uracil phosphoribosyltransferase homolog UPRT Homo sapiens (Human) female pregnancy [GO:0007565]; lactation [GO:0007595]; response to insulin [GO:0032868]; UMP biosynthetic process [GO:0006222] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; ribosylnicotinamide kinase activity [GO:0050262] QIGAQLKLLPMNDQIR;VLLMYPILSTGNTVIEAVK 2 11.3 0.90124 -0.26044 0 0 12.2819 11.9155 0 0 0 0 0 0 0 0 Q96BW1 UPP_HUMAN Uracil phosphoribosyltransferase homolog UPRT Homo sapiens (Human) female pregnancy [GO:0007565]; lactation [GO:0007595]; response to insulin [GO:0032868]; UMP biosynthetic process [GO:0006222] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; ribosylnicotinamide kinase activity [GO:0050262] QIGAQLKLLPMNDQIR;SIDNSCSAFHHQTCCGR 2 18.8 0.65975 0.1691 0 0 0 0 0 7.58481 0 0 0 0 0 0 Q96BW5 PTER_HUMAN N-acetyltaurine hydrolase (EC 3.1.-.-) (Phosphotriesterase-related protein) PTER Homo sapiens (Human) catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]; regulation of appetite [GO:0032098]; taurine metabolic process [GO:0019530] cytosol [GO:0005829]; extracellular exosome [GO:0070062] N-acetyltaurine hydrolase activity [GO:0141215]; zinc ion binding [GO:0008270] MLLRGITENVLDK;VQTVLGLVEPSKLGR 2 8 0.96385 -1.0935 0 0 0 0 0 0 7.00865 0 11.3965 0 0 0 Q96BW9 TAM41_HUMAN "Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41)" TAMM41 C3orf31 Homo sapiens (Human) cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024] extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] phosphatidate cytidylyltransferase activity [GO:0004605] TMSDHWQCCWK 1 2.4 0.80591 0.011801 0 0 0 0 0 0 0 0 4.87352 0 0 0 Q96BX8 MOB3A_HUMAN MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) MOB3A MOBKL2A Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] EFGLIDTK 1 3.7 0.27374 0.25644 17.2707 17.2999 17.1745 12.4445 0 13.6316 0 0 0 17.5946 17.4855 0 Q96BY2 MOAP1_HUMAN Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4) MOAP1 PNMA4 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein insertion into mitochondrial membrane [GO:0051204]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ubiquitin protein ligase binding [GO:0031625] GMDMNPR;LNEFLAGEGMTVGELSR 2 6.8 0.95487 -0.79774 0 6.59128 0 0 0 0 0 0 0 0 0 0 Q96BY6 DOC10_HUMAN Dedicator of cytokinesis protein 10 (Zizimin-3) DOCK10 KIAA0694 ZIZ3 Homo sapiens (Human) B cell homeostasis [GO:0001782]; dendritic spine morphogenesis [GO:0060997]; marginal zone B cell differentiation [GO:0002315]; positive regulation of GTPase activity [GO:0043547]; regulation of cell migration [GO:0030334]; regulation of postsynapse assembly [GO:0150052]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EVGFALQEDQDVRHLALAVLKNLMAK;FVFKTRACK;ISADFHVDLNHAAVR;KDLLEPESVIKPFEEK;LIKEDQLEYQEELR;LPSHSFEIDHEDADK;VAEVVNSEKRLFGR 7 5 0.97272 -1.3743 7.22072 7.83061 0 5.48394 0 7.99577 8.81625 9.22475 12.8142 5.53487 0 0 Q96BY7 ATG2B_HUMAN Autophagy-related protein 2 homolog B ATG2B C14orf103 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495] EETGSHSPVCLQLHYKHSENR;VMDMGLLELTITAVK 2 1.7 0.9539 -0.92323 0 0 0 0 0 0 0 14.1089 0 0 0 0 Q96BY9 SARAF_HUMAN Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66) SARAF TMEM66 XTP3 HSPC035 NPD003 PSEC0019 UNQ1967/PRO4499 Homo sapiens (Human) calcium ion transport [GO:0006816]; regulation of store-operated calcium entry [GO:2001256] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268] SGLITIVVLLGIAFVVYK 1 10.8 0.68306 0.1643 1.80422 0 0 0 0 0 0 0 0 0 6.8315 0 Q96BZ8 LENG1_HUMAN Leukocyte receptor cluster member 1 LENG1 Homo sapiens (Human) nucleoplasm [GO:0005654] EEEKERER;ELLEEGK;ELLEEGKGVIR;KARHQNSLPELEAAEAGAPGSGPVDLFR;RDEAQAREEEK 5 20.5 0.97522 -4.175 0 0 0 0 11.5691 10.9802 0 0 9.42888 11.8136 0 0 Q96BZ9 TBC20_HUMAN TBC1 domain family member 20 TBC1D20 C20orf140 Homo sapiens (Human) acrosome assembly [GO:0001675]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid droplet organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] MPIIDQVNPELHDFMQR 1 9.9 0.7809 0.021497 0 0 0 0 0 0 6.9318 0 0 0 0 0 Q96C03 MID49_HUMAN Mitochondrial dynamics protein MID49 (Mitochondrial dynamics protein of 49 kDa) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein) MIEF2 MID49 SMCR7 Homo sapiens (Human) mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of mitochondrion organization [GO:0010821] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] CWAVRRTQLEFCPR;LVLGVGGAAVLGIATLAVKRFIDR;MGLSPNLDRQTMAEFSQKR 3 12.3 0.95793 -1.016 0 0 10.4168 7.05441 0 0 6.80903 0 0 0 9.22337 0 Q96C11 FGGY_HUMAN FGGY carbohydrate kinase domain-containing protein (D-ribulokinase FGGY) (EC 2.7.1.47) FGGY Homo sapiens (Human) carbohydrate phosphorylation [GO:0046835]; neuron cellular homeostasis [GO:0070050]; pentose metabolic process [GO:0019321] cytoplasm [GO:0005737] D-ribulokinase activity [GO:0019150] ATARCQSIYAYLNSHLDLIKK;AVSQVNR 2 5.1 0.91706 -0.3995 0 0 0 0 0 0 13.3119 8.89039 13.1477 11.1348 0 0 Q96C11 FGGY_HUMAN FGGY carbohydrate kinase domain-containing protein (D-ribulokinase FGGY) (EC 2.7.1.47) FGGY Homo sapiens (Human) carbohydrate phosphorylation [GO:0046835]; neuron cellular homeostasis [GO:0070050]; pentose metabolic process [GO:0019321] cytoplasm [GO:0005737] D-ribulokinase activity [GO:0019150] ATARCQSIYAYLNSHLDLIKK;NLREICWDK 2 6.5 0.98127 -1.5903 0 0 11.0356 0 0 0 0 0 0 0 0 0 Q96C12 ARMC5_HUMAN Armadillo repeat-containing protein 5 ARMC5 Homo sapiens (Human) "adrenal cortex development [GO:0035801]; anatomical structure morphogenesis [GO:0009653]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; regulation of steroid biosynthetic process [GO:0050810]; T cell proliferation [GO:0042098]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ARGGLRPLLALLR;DPRASAWHPRIVAALVGFLYDTGALGR;SPAAAIEEPWGR;TPGRSPAAAIEEPWGR 4 6 0.91543 -0.39312 0 0 0 0 5.76765 0 0 0 9.3253 10.484 10.0541 0 Q96C19 EFHD2_HUMAN EF-hand domain-containing protein D2 (Swiprosin-1) EFHD2 SWS1 Homo sapiens (Human) membrane raft [GO:0045121] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EVDEDFDSKLSFREFLLIFR;LSEIDVSSEGVK;VQAINVSSR 3 17.1 0 2.7132 0 0 0 0 8.0457 0 0 0 0 10.0359 0 0 Q96C23 GALM_HUMAN Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase) GALM BLOCK25 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246] VDIISWGCTITALEVK 1 4.7 0.89236 -0.2229 0 0 0 0 0 0 0 0 0 9.66965 0 0 Q96C24 SYTL4_HUMAN Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) SYTL4 Homo sapiens (Human) exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; multivesicular body sorting pathway [GO:0071985]; negative regulation of insulin secretion [GO:0046676]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]; regulation of plasma membrane repair [GO:1905684] endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; transport vesicle membrane [GO:0030658] metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267] DSLDKSGLFPEWK;EPSVLFEVPKLK;ISAESPTGLPSHK;MSLRHKPAVSKR 4 7.5 0.98111 -1.7383 0 5.14323 0 11.1487 0 0 10.4611 0 0 0 0 6.33823 Q96C34 RUND1_HUMAN RUN domain-containing protein 1 RUNDC1 LP5161 Homo sapiens (Human) in utero embryonic development [GO:0001701] LSSLKFSLPVDLAVRQLK;MAAVEAAAEPVTVVAAVGPK;TGNGCSRTGSSR;TGSSRTPPGNSKTK 4 9.6 0.91533 -0.36778 0 0 10.2794 0 0 0 7.76401 9.31064 0 0 0 10.7067 Q96C36 P5CR2_HUMAN Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) PYCR2 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] pyrroline-5-carboxylate reductase activity [GO:0004735] ISPAALKK;SVGFIGAGQLAYALAR 2 7.5 0 7.3868 9.83327 0 10.1518 0 0 0 0 8.92713 8.15543 0 0 6.85187 Q96C45 ULK4_HUMAN Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; protein kinase C deactivation [GO:0042313]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of p38MAPK cascade [GO:1900744] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELLQNSQSR;LLDSPSTCIR;VVNHMAAK 3 2.1 0.97577 -1.4632 0 0 0 10.1483 0 0 0 0 0 0 13.0861 8.63626 Q96C55 ZN524_HUMAN Zinc finger protein 524 ZNF524 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] CPLCPRRFR 1 3.4 0.9759 -1.453 0 0 0 0 9.77474 0 0 0 0 0 0 0 Q96C74 ROP1L_HUMAN Ropporin-1-like protein (ROPN1-like protein) (AKAP-associated sperm protein) ROPN1L ASP RSPH11 Homo sapiens (Human) epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240] cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534] identical protein binding [GO:0042802] ALLQLDPCENK;NLCLPKEK 2 8.3 0.96651 -1.2737 10.0958 0 0 0 0 0 0 0 0 0 0 0 Q96C90 PP14B_HUMAN Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein) PPP1R14B PLCB3N PNG Homo sapiens (Human) innate immune response [GO:0045087] cytoplasm [GO:0005737] protein serine/threonine phosphatase inhibitor activity [GO:0004865] GMQKLSTPQK;RLNLEEWILEQLTR 2 16.3 0.77039 0.053888 0 0 0 0 6.1868 0 9.83374 0 0 0 0 0 Q96CC6 RHDF1_HUMAN Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) RHBDF1 C16orf8 DIST1 IRHOM1 Homo sapiens (Human) cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] growth factor binding [GO:0019838] LTNRTYRK 1 0.9 0.89679 -0.24586 0 0 0 0 0 6.87566 0 0 0 0 0 0 Q96CD0 FBXL8_HUMAN F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) FBXL8 FBL8 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] AEPGEGLPEEVLALIFRHLSLRDR;LEFEPSR;LSFTLDDALVLQAAR 3 12.3 0.98084 -1.7435 0 0 0 0 10.6862 0 0 0 8.74069 9.50779 0 0 Q96CD2 COAC_HUMAN Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC) PPCDC COAC MDS018 UNQ9365/PRO34154 Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937] cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513] FMN binding [GO:0010181]; identical protein binding [GO:0042802]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633] SRSDPVLHIDLR;VASGICDNLLTCVMR 2 13.2 0.91687 -0.41502 10.9366 12.6035 0 0 0 6.41383 0 0 0 10.2373 0 0 Q96CE8 T4S18_HUMAN Transmembrane 4 L6 family member 18 TM4SF18 Homo sapiens (Human) membrane [GO:0016020] CCQSENCSKK 1 5 0.71287 0.15321 0 0 0 0 0 0 0 4.42848 0 0 0 0 Q96CG8 CTHR1_HUMAN Collagen triple helix repeat-containing protein 1 CTHRC1 UNQ762/PRO1550 Homo sapiens (Human) "cochlea morphogenesis [GO:0090103]; establishment of planar polarity involved in neural tube closure [GO:0090177]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; ossification involved in bone remodeling [GO:0043932]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasm [GO:0016528] frizzled binding [GO:0005109]; Wnt-protein binding [GO:0017147] ESFEESWTPNYK;IIIEELPIYML 2 9.9 0.93682 -0.5501 0 5.71408 0 8.61257 0 0 0 0 8.38547 0 0 0 Q96CJ1 EAF2_HUMAN ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) EAF2 TRAITS BM-040 Homo sapiens (Human) apoptotic process [GO:0006915]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] transcription elongation factor activity [GO:0003711] AEASLMDQMSSCDSSSDSK;HSPSEDK;LGESFEK;SSSSSSSEDSSSDSEDEDCK 4 20.4 0.44173 0.19385 13.547 5.14918 10.5474 0 7.83042 4.86552 0 0 0 5.63813 0 0 Q96CM3 RUSD4_HUMAN "Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4)" RPUSD4 Homo sapiens (Human) mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; RNA splicing [GO:0008380]; rRNA pseudouridine synthesis [GO:0031118] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770] mitochondrial ribosomal large subunit rRNA binding [GO:1990400]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029] VQEIVRFTR;YIPLHLHARQLILPALGSGK 2 7.7 0.97953 -1.5455 0 0 0 0 0 0 0 0 0 9.23453 0 0 Q96CN4 EVI5L_HUMAN EVI5-like protein (Ecotropic viral integration site 5-like protein) EVI5L Homo sapiens (Human) negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] LLEADSKSMR 1 1.3 0.97999 -1.5665 0 0 0 0 0 10.3813 0 0 0 0 0 0 Q96CN5 LRC45_HUMAN Leucine-rich repeat-containing protein 45 LRRC45 Homo sapiens (Human) centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] AIQAEER;AKLQMTEAALALSEQK;LDLATQSLTVETCR;LSLEEELSR;VGQLQEALNER;VMASDHREALLDR 6 10.4 0.98061 -2.0139 0 0 15.1068 0 0 10.6199 0 0 7.23946 0 7.60333 0 Q96CN9 GCC1_HUMAN GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) GCC1 Homo sapiens (Human) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138] small GTPase binding [GO:0031267] DLELEQLR;LPTSASWWPSGKR 2 2.7 0.8825 -0.16382 0 0 0 0 0 8.57478 11.4898 0 0 0 0 0 Q96CP6 ASTRA_HUMAN Protein Aster-A (GRAM domain-containing protein 1A) GRAMD1A KIAA1533 Homo sapiens (Human) autophagy [GO:0006914]; cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] EILLQGR;KMQSWYSMLSPTYKQR 2 3.2 0.97525 -1.4345 0 0 0 0 0 11.9001 10.4356 0 0 0 0 0 Q96CP7 TLCD1_HUMAN TLC domain-containing protein 1 (Calfacilitin) TLCD1 Homo sapiens (Human) membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035] plasma membrane [GO:0005886] LLHPALPLLLGATLTFRALR 1 8.1 0.81826 -0.01737 0 0 0 0 0 0 0 0 9.69799 0 0 0 Q96CS2 HAUS1_HUMAN HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C) HAUS1 CCDC5 HEIC Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922] ELDSIEAELTR 1 4 0.91645 -0.34997 0 0 0 0 0 9.48202 0 0 0 0 0 0 Q96CS4 ZN689_HUMAN Zinc finger protein 689 ZNF689 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGEKPYPCPDCERR;LHACDDCGRRFAYPSLLASHR 2 7.4 0.67449 0.16709 0 5.18986 11.2081 0 0 4.04133 0 0 0 0 0 0 Q96CS7 PKHB2_HUMAN Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2) PLEKHB2 EVT2 Homo sapiens (Human) regulation of cell differentiation [GO:0045595] membrane [GO:0016020]; recycling endosome membrane [GO:0055038] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" DCMLQIVCR;QNIEDKVHMPMDCINIR;RSVQISVLLPAVNIRR 3 13.6 0.91746 -0.35382 0 0 0 8.42886 0 9.54529 10.6791 0 0 0 7.15228 0 Q96CT2 KLH29_HUMAN Kelch-like protein 29 (Kelch repeat and BTB domain-containing protein 9) KLHL29 KBTBD9 KIAA1921 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DLVNEAK 1 0.8 0.91754 -0.35939 0 0 0 0 0 0 0 0 8.5108 0 0 0 Q96CT7 CC124_HUMAN Coiled-coil domain-containing protein 124 CCDC124 Homo sapiens (Human) cell division [GO:0051301]; transcription by RNA polymerase II [GO:0006366] centrosome [GO:0005813]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886] RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] AVPFNAPK;ELEDAYWK;FQGENTK;RDHQLREAPDTAEK;VTRAQIEDTLR 5 21.5 0.98098 -1.7858 0 9.56828 0 0 8.77581 6.98959 0 6.38567 0 0 8.85854 0 Q96CU9 FXRD1_HUMAN FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) FOXRED1 FP634 Homo sapiens (Human) mitochondrial respiratory chain complex I assembly [GO:0032981] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] VLPHGMGR 1 1.6 0.91328 -0.39033 0 0 0 0 0 0 0 0 0 0 8.16626 0 Q96CV9 OPTN_HUMAN Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) OPTN FIP2 GLC1E HIP7 HYPL NRP Homo sapiens (Human) cell death [GO:0008219]; cellular response to unfolded protein [GO:0034620]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of receptor recycling [GO:0001920]; positive regulation of autophagy [GO:0010508]; positive regulation of xenophagy [GO:1904417]; protein localization to Golgi apparatus [GO:0034067]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; type 2 mitophagy [GO:0061734] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-macromolecule adaptor activity [GO:0030674] DQLRTQVVR;EELGKLKGK;ELSEKLELAEK;HSPGPTR 4 6.2 0.95252 -0.75731 0 0 0 0 0 0 0 10.1655 0 9.19525 10.1961 0 Q96CW1 AP2M1_HUMAN AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) AP2M1 CLAPM1 KIAA0109 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; regulation of vesicle size [GO:0097494]; synaptic vesicle endocytosis [GO:0048488]; vesicle budding from membrane [GO:0006900]; vesicle-mediated transport [GO:0016192] AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic vesicle [GO:0008021] clathrin adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; lipid binding [GO:0008289]; low-density lipoprotein particle receptor binding [GO:0050750]; signal sequence binding [GO:0005048]; transmembrane transporter binding [GO:0044325] ASENAIVWK;NAVDAFR;SGIYETR;SISFIPPDGEFELMRYR;SPVTNIAR;TFITQQGIK 6 13.1 0.96595 -1.13 0 0 0 0 0 9.28621 0 10.387 0 10.1025 9.83466 0 Q96CW5 GCP3_HUMAN Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) TUBGCP3 GCP3 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; single fertilization [GO:0007338]; spindle assembly [GO:0051225] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; polar microtubule [GO:0005827]; spindle [GO:0005819] gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] SINFLHQVCHDQTPTTK;WSILYLLLSLSEDPR;YLLDVLNKK 3 4.5 0.36985 0.22779 0 0 6.70819 0 0 8.24479 0 0 0 0 9.60958 0 Q96CW6 S7A6O_HUMAN Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) SLC7A6OS Homo sapiens (Human) developmental process [GO:0032502]; hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nucleus [GO:0005634] EVLRPSRDSQQR;EVRQEGRYR;KRSAEPAEALVLACK;RLRSDAVESAAQK 4 15.9 0.95294 -0.77517 0 0 11.6349 0 0 0 9.43863 13.1005 0 0 0 0 Q96CW9 NTNG2_HUMAN Netrin-G2 (Laminet-2) NTNG2 KIAA1857 LMNT2 UNQ9381/PRO34206 Homo sapiens (Human) axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic specialization assembly [GO:0098698]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552] CNETGFCECR 1 1.9 0.81524 -0.0032909 0 0 0 0 0 0 0 0 0 0 5.88699 0 Q96CX6 LRC58_HUMAN Leucine-rich repeat-containing protein 58 LRRC58 Homo sapiens (Human) intracellular signal transduction [GO:0035556] LLLPHNRLVSLPR;QIKFVDFCGK;TLLAKNNR 3 8.4 0.97299 -2.6177 5.8505 0 0 11.305 0 0 0 8.91919 0 0 0 0 Q96D03 DDT4L_HUMAN DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2) DDIT4L REDD2 RTP801L Homo sapiens (Human) negative regulation of signal transduction [GO:0009968] cytoplasm [GO:0005737] TLILSSGFRLVKK 1 6.7 0.86865 -0.093886 0 0 0 0 0 0 0 10.2501 0 0 0 0 Q96D05 F241B_HUMAN Protein FAM241B FAM241B C10orf35 Homo sapiens (Human) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] TTTQPPR;VRTTTQPPRGSIPR 2 11.6 0.37633 0.22329 0 0 5.96643 0 0 0 10.0143 0 0 0 0 0 Q96D09 GASP2_HUMAN G-protein coupled receptor-associated sorting protein 2 (GASP-2) GPRASP2 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] amyloid-beta binding [GO:0001540]; G protein-coupled receptor binding [GO:0001664] DEACFDLNPCPVYK;EDCFESESEDEFYK;TKFHVLKMLLNLSENPAVAK;TNREDCFESESEDEFYK;VKQEPRFEEEVIIGSWFWAEK 5 8.6 0.83756 -0.032914 0 0 0 0 4.92434 0 0 5.1359 12.2891 0 7.89439 0 Q96D15 RCN3_HUMAN Reticulocalbin-3 (EF-hand calcium-binding protein RLP49) RCN3 UNQ239/PRO272 Homo sapiens (Human) collagen biosynthetic process [GO:0032964]; ERAD pathway [GO:0036503]; lung epithelium development [GO:0060428]; phospholipid homeostasis [GO:0055091]; positive regulation of peptidase activity [GO:0010952]; protein secretion [GO:0009306]; protein transport [GO:0015031]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; surfactant homeostasis [GO:0043129] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231] calcium ion binding [GO:0005509] DFRDLNK 1 2.1 0.89936 -0.25819 0 0 10.461 0 0 0 0 0 0 0 0 0 Q96D21 RHES_HUMAN GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2) RASD2 TEM2 Homo sapiens (Human) "locomotory behavior [GO:0007626]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]" plasma membrane [GO:0005886]; synapse [GO:0045202] G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGKSSIVSRFLNGR 1 5.3 0.86512 -0.088044 0 0 0 0 8.59444 0 0 0 0 0 0 0 Q96D46 NMD3_HUMAN 60S ribosomal export protein NMD3 (hNMD3) NMD3 CGI-07 Homo sapiens (Human) positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] ERENMDTDDER;HTLGEVWVQK;STFSVEIVPICK 3 6.6 0.96717 -1.3098 0 2.39383 0 9.79411 0 0 12.0203 0 12.174 0 11.4427 0 Q96D53 COQ8B_HUMAN "Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B)" COQ8B ADCK4 Homo sapiens (Human) cerebellar Purkinje cell layer morphogenesis [GO:0021692]; ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase activity [GO:0016301]; lipid binding [GO:0008289] EAACAQNFR;IVQTLCTVR;VLEEELGR;VLEEELGRDWQAK 4 5.7 0.97818 -1.5293 0 11.3597 0 0 0 0 0 0 0 8.26458 0 0 Q96D96 HVCN1_HUMAN Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) HVCN1 VSOP UNQ578/PRO1140 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; innate immune response [GO:0045087]; positive regulation of superoxide anion generation [GO:0032930]; proton transmembrane transport [GO:1902600]; regulation of acrosome reaction [GO:0060046]; regulation of intracellular pH [GO:0051453]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; response to pH [GO:0009268]; response to zinc ion [GO:0010043]; single fertilization [GO:0007338] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; sperm flagellum [GO:0036126] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated proton channel activity [GO:0030171] IQHLEFSCSEKEQEIERLNK;LEFFHHK;LWRVARIINGIIISVK;SERQLLR;VARIINGIIISVKTR 5 19 0.98056 -1.7255 0 2.94782 0 10.4845 7.05983 0 0 4.976 0 10.1083 0 5.24336 Q96D98 EID2B_HUMAN EP300-interacting inhibitor of differentiation 2B (EID-2B) (EID-2-like inhibitor of differentiation 3) (EID-3) EID2B EID3 Homo sapiens (Human) cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662] nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] LLRDFEER 1 5 0.91283 -0.33804 0 12.0154 0 0 0 0 0 0 0 0 0 0 Q96DB2 HDA11_HUMAN Histone deacetylase 11 (HD11) (EC 3.5.1.98) HDAC11 Homo sapiens (Human) chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; oligodendrocyte development [GO:0014003] histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]" LLSDSMLVEAR 1 3.2 0.93389 -0.50454 0 0 0 0 0 10.6561 0 0 0 0 0 0 Q96DB5 RMD1_HUMAN Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) RMDN1 FAM82B CGI-90 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] GAAPGSR;LHNKKLAAFWLMK 2 6.4 0.69177 0.16239 0 0 0 7.00495 0 0 12.3286 0 10.2795 0 0 0 Q96DB9 FXYD5_HUMAN FXYD domain-containing ion transport regulator 5 (Dysadherin) FXYD5 DYSAD IWU1 HSPC113 UNQ2561/PRO6241 Homo sapiens (Human) microvillus assembly [GO:0030033]; negative regulation of calcium-dependent cell-cell adhesion [GO:0046588]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cadherin binding [GO:0045296]; sodium channel regulator activity [GO:0017080] KRGLLVAAVLFITGIIILTSGK 1 12.4 0.86532 -0.087715 0 0 0 0 4.22936 0 0 0 0 0 0 0 Q96DD0 LRC39_HUMAN Leucine-rich repeat-containing protein 39 (Myosin-interacting M-band-associated stress-responsive protein) (Myomasp) LRRC39 UNQ6500/PRO21368 Homo sapiens (Human) intracellular signal transduction [GO:0035556] M band [GO:0031430] ELFGLQFMHTYIQESRR;EVWEKRIK 2 7.5 0.95581 -0.87111 0 0 0 9.31829 9.65209 0 0 0 0 8.70134 0 0 Q96DD7 SHSA4_HUMAN Protein shisa-4 (Transmembrane protein 58) SHISA4 C1orf40 TMEM58 UNQ583/PRO1153 Homo sapiens (Human) membrane [GO:0016020] NGSWHPGFNCEFFTFCCGTCYHR 1 11.7 0.70089 0.16126 0 0 0 0 0 0 0 0 0 0 0 6.80116 Q96DE0 NUD16_HUMAN U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (Nudix hydrolase 16) (U8 snoRNA-binding protein H29K) (m7GpppN-mRNA hydrolase) NUDT16 Homo sapiens (Human) dITP catabolic process [GO:0035863]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; negative regulation of rRNA processing [GO:2000233]; positive regulation of cell cycle process [GO:0090068]; sno(s)RNA catabolic process [GO:0016077] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; chloride ion binding [GO:0031404]; cobalt ion binding [GO:0050897]; dIDP phosphatase activity [GO:0097383]; dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; IDP phosphatase activity [GO:1990003]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; phosphodiesterase decapping endonuclease activity [GO:1990174]; protein homodimerization activity [GO:0042803]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; snoRNA binding [GO:0030515] AFSPPRKHPWR 1 5.7 0.86944 -0.090884 8.03364 0 0 0 0 0 0 0 0 0 0 0 Q96DE0 NUD16_HUMAN U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (Nudix hydrolase 16) (U8 snoRNA-binding protein H29K) (m7GpppN-mRNA hydrolase) NUDT16 Homo sapiens (Human) dITP catabolic process [GO:0035863]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; negative regulation of rRNA processing [GO:2000233]; positive regulation of cell cycle process [GO:0090068]; sno(s)RNA catabolic process [GO:0016077] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; chloride ion binding [GO:0031404]; cobalt ion binding [GO:0050897]; dIDP phosphatase activity [GO:0097383]; dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; IDP phosphatase activity [GO:1990003]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; phosphodiesterase decapping endonuclease activity [GO:1990174]; protein homodimerization activity [GO:0042803]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; snoRNA binding [GO:0030515] EGRTWECFLIGSER 1 8.8 0.92194 -0.44345 0 0 0 0 0 0 0 5.6931 0 0 0 0 Q96DF8 ESS2_HUMAN Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) ESS2 DGCR13 DGCR14 DGSH DGSI ES2 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]" catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634] VTENLASLTPKGLSPAMSPALQR 1 4.8 0.83451 -0.029624 12.0588 0 0 0 0 0 0 0 0 0 0 0 Q96DG6 CMBL_HUMAN Carboxymethylenebutenolidase homolog (EC 3.1.-.-) CMBL Homo sapiens (Human) xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; extracellular exosome [GO:0070062] hydrolase activity [GO:0016787] EHCKVEYQIK;EVQVEHIK 2 7.3 0.9767 -2.2766 0 0 0 0 0 0 0 8.8632 9.55917 0 0 0 Q96DL1 NXPE2_HUMAN NXPE family member 2 (Protein FAM55B) NXPE2 FAM55B Homo sapiens (Human) membrane [GO:0016020] FNETKNINDCLERK;HGHPFVTK;QIKFNETK;VEKILIHRILTLFPNAIAR 4 7.9 0.97221 -2.712 0 0 0 13.5432 0 0 13.8959 14.4424 14.4583 7.17343 11.3561 13.9645 Q96DM1 PGBD4_HUMAN PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) AMIPRQR;GFSRMDKWK;LSGRHFPK;WSARAMIPR 4 4.8 0.97872 -1.9074 6.28153 0 8.5755 0 0 0 9.48073 0 10.4962 0 0 0 Q96DN0 ERP27_HUMAN Endoplasmic reticulum resident protein 27 (ER protein 27) (ERp27) (Inactive protein disulfide-isomerase 27) ERP27 C12orf46 UNQ781/PRO1575 Homo sapiens (Human) protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] LVDNEQLNLEDEDIESIDATK 1 7.7 0.78431 0.023726 0 0 7.25304 0 0 0 0 0 0 0 0 0 Q96DN2 VWCE_HUMAN von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein) VWCE URG11 Homo sapiens (Human) cellular response to virus [GO:0098586] cytoplasm [GO:0005737]; extracellular region [GO:0005576] calcium ion binding [GO:0005509] DCNYEGR;WTEPGCSQCWCEDGK 2 2.3 0.88184 -0.16708 5.29594 0 3.86086 6.94122 0 0 0 0 7.50819 0 0 0 Q96DN5 TBC31_HUMAN TBC1 domain family member 31 (WD repeat-containing protein 67) TBC1D31 WDR67 Homo sapiens (Human) cilium assembly [GO:0060271] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] molecular adaptor activity [GO:0060090] ILAAGGK;KASALSDASRK;LDDEIGRK;LIEAGETQSQK;LSSSDLK;MQSTDLGNKESGKIWHR;VQQPAKSR;YAITTSSDTAQLWDLDTFQR 8 8.3 0.98054 -2.0359 0 11.1682 8.68138 0 0 9.61745 0 10.0217 0 0 10.563 0 Q96DP5 FMT_HUMAN "Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)" MTFMT FMT FMT1 Homo sapiens (Human) conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951] mitochondrion [GO:0005739] methionyl-tRNA formyltransferase activity [GO:0004479] ALARLGWEDCR 1 2.8 0.92169 -0.44532 0 0 0 0 0 0 0 0 0 0 4.94341 0 Q96DR4 STAR4_HUMAN StAR-related lipid transfer protein 4 (START domain-containing protein 4) (StARD4) STARD4 Homo sapiens (Human) cholesterol import [GO:0070508]; cholesterol transport involved in cholesterol storage [GO:0010879]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of cholesterol metabolic process [GO:0090205] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] LKNTLIQYHSIEEDK 1 7.3 0.81306 -0.01152 0 0 0 0 0 0 0 0 0 0 2.78188 0 Q96DR7 ARHGQ_HUMAN Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) ARHGEF26 SGEF HMFN1864 Homo sapiens (Human) endothelial cell morphogenesis [GO:0001886]; regulation of actin cytoskeleton organization [GO:0032956]; ruffle assembly [GO:0097178] cytosol [GO:0005829]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085] KMLKGQGTFDGEENAVLYQNYK;VILIVGFMEMK 2 7.4 0.78432 0.020925 0 12.1636 11.7858 0 0 0 0 10.2102 0 0 0 0 Q96DT5 DYH11_HUMAN Dynein axonemal heavy chain 11 (Axonemal beta dynein heavy chain 11) (Ciliary dynein heavy chain 11) DNAH11 Homo sapiens (Human) cardiac septum morphogenesis [GO:0060411]; cilium movement involved in cell motility [GO:0060294]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; learning or memory [GO:0007611]; protein localization to motile cilium [GO:0120229]; regulation of cilium beat frequency [GO:0003356] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; proximal portion of axoneme [GO:0120134] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AGHNYGPGGNK;DPEFNPNLIR;IGDKECEFNK;LAYPSTYGLAQWFNDLLLRCR;LERLEFGGTK;LKSEEKTAK;LLKGLWDVIIYVR;LLNGLHLSPQAELDFWMMRR;LRPWDFQSHLVFCRFDK;LTADVTK;LTASFEK;TIKLANR;VVSPQAFTWLSQLRHR;WPLVIDPQQQGIKWIK 14 3.9 0.9782 -7.8344 10.1481 0 12.1746 9.34232 7.65528 0 8.14195 10.0737 0 6.60751 0 9.21106 Q96DT7 ZBT10_HUMAN Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) ZBTB10 RINZF RINZFC Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] "chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; telomeric DNA binding [GO:0042162]" CMVCKKIFMLAASVGIR;DTGLMSCGWCQK;KGILCDVSIVVSGK;NILVAGSRFFKTLYCFSNK 4 7.1 0.98102 -1.7343 3.54399 0 10.3838 0 0 0 0 11.7821 0 0 0 9.37929 Q96DU3 SLAF6_HUMAN SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352) SLAMF6 KALI UNQ6123/PRO20080 Homo sapiens (Human) immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of type II interferon production [GO:0032729]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] VNFITWLFNETSLAFIVPHETK 1 6.6 0.78663 0.017575 0 0 0 0 0 0 0 0 7.21412 0 5.67627 0 Q96DU7 IP3KC_HUMAN "Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)" ITPKC IP3KC Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]" QKTEPDRSSLR;SGSKPWKK;YSPFVVSFR 3 4.1 0.97518 -1.4585 0 0 0 0 9.43694 0 0 0 0 7.14323 0 0 Q96DU9 PABP5_HUMAN Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) PABPC5 PABP5 Homo sapiens (Human) cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] LNNRQVYVGRFK;SGVGNIFIK 2 5.5 0.87121 -0.095717 0 0 0 0 2.54686 0 0 0 0 0 0 0 Q96DV4 RM38_HUMAN "Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38)" MRPL38 HSPC262 Homo sapiens (Human) mitochondrial translation [GO:0032543] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] EYFGEKTDPK 1 2.6 0.88651 -0.19183 0 0 0 0 0 0 8.34301 8.73715 0 0 0 0 Q96DX4 RSPRY_HUMAN RING finger and SPRY domain-containing protein 1 RSPRY1 KIAA1972 UNQ328/PRO444 Homo sapiens (Human) proteolysis involved in protein catabolic process [GO:0051603] cytoplasm [GO:0005737]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] DSKFLNHEGYGIGDDEYSCAYDGCR;EGDTVGFLLDLNEK 2 6.8 0.87335 -0.11127 0 0 0 0 11.0998 0 0 0 0 0 0 7.20016 Q96DX5 ASB9_HUMAN Ankyrin repeat and SOCS box protein 9 (ASB-9) ASB9 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVLPEDLKQFLLHL 1 4.8 0.9215 -0.44585 0 0 0 0 0 0 0 0 0 11.2203 0 0 Q96DX7 TRI44_HUMAN Tripartite motif-containing protein 44 (Protein DIPB) TRIM44 DIPB Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein stabilization [GO:0050821]; regulation of gene expression [GO:0010468]; response to angiotensin [GO:1990776] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ECGFCYCR;VIADEEQK;VTRDQMK 3 6.7 0.978 -2.1566 0 5.24291 8.61563 0 0 5.15243 0 0 0 0 13.6171 0 Q96DX8 RTP4_HUMAN Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4) RTP4 IFRG28 Z3CXXC4 Homo sapiens (Human) defense response to virus [GO:0051607]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849] AFGWFRCSSCQR 1 4.9 0.92524 -0.45104 0 0 0 0 0 0 0 0 0 0 10.6458 0 Q96DY2 DRC10_HUMAN Dynein regulatory complex protein 10 (IQ domain-containing protein D) IQCD DRC10 Homo sapiens (Human) ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] EDMEGMLGEDVMR;EKERQLQEQK;LLTSPMEAR;NRNAEVEK 4 8.9 0.93028 -0.4876 0 8.09645 0 0 0 9.96593 9.7839 0 4.80488 0 0 0 Q96DY7 MTBP_HUMAN Mdm2-binding protein (hMTBP) MTBP Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic nuclear division [GO:0045839]; protein localization to kinetochore [GO:0034501]; regulation of protein ubiquitination [GO:0031396]; traversing start control point of mitotic cell cycle [GO:0007089] chromatin [GO:0000785]; kinetochore [GO:0000776] HVLQNLETFEKTK 1 1.4 0.91689 -0.41353 0 0 6.8175 0 0 0 0 0 0 0 0 0 Q96DZ1 ERLEC_HUMAN Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein) ERLEC1 C2orf30 XTP3TPB UNQ1878/PRO4321 Homo sapiens (Human) "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; retrograde protein transport, ER to cytosol [GO:0030970]" endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322] unfolded protein binding [GO:0051082] FRASPVNDIFCQSLPGSPFKPLTLRQLEQQEEILR 1 7.2 0.84935 -0.070513 0 0 0 0 0 0 10.8174 10.7703 0 0 0 3.87696 Q96DZ5 CLIP3_HUMAN CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) CLIP3 CLIPR59 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; fat cell differentiation [GO:0045444]; membrane biogenesis [GO:0044091]; negative regulation of microtubule polymerization [GO:0031115]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of apoptotic process [GO:0043065]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of endocytosis [GO:0045807]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; protein transport along microtubule [GO:0098840] cell cortex [GO:0005938]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] ganglioside binding [GO:0035594]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] TLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDR;VHQVTMTQPK 2 9.1 0.98079 -1.6232 0 0 0 0 0 0 0 0 0 0 10.6858 0 Q96E11 RRFM_HUMAN "Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial)" MRRF Homo sapiens (Human) ribosome disassembly [GO:0032790]; translation [GO:0006412] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ribosomal large subunit binding [GO:0043023] SKDTVSEDTIR 1 4.2 0.91611 -0.43329 0 0 0 0 0 0 3.44784 4.0306 0 0 0 0 Q96E29 MTEF3_HUMAN "Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3) (mTERF domain-containing protein 1, mitochondrial)" MTERF3 MTERFD1 CGI-12 Homo sapiens (Human) mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] transcription cis-regulatory region binding [GO:0000976] LDFEKDIK;LLTGSLEPVK 2 4.3 0.97963 -1.8866 0 0 0 0 9.00149 0 0 0 0 0 0 0 Q96E35 ZMY19_HUMAN Zinc finger MYND domain-containing protein 19 (Melanin-concentrating hormone receptor 1-interacting zinc finger protein) (MCH-R1-interacting zinc finger protein) ZMYND19 MIZIP Homo sapiens (Human) cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] metal ion binding [GO:0046872] GGVAPGFQVVHLNAVTVDNRLDNLQLVPWGWRPK;QLREFNICGR 2 19.4 0.95594 -0.85191 0 11.3445 0 0 9.48121 0 0 0 0 0 0 0 Q96E40 SACA9_HUMAN Sperm acrosome-associated protein 9 SPACA9 C9orf9 Homo sapiens (Human) axoneme assembly [GO:0035082]; flagellated sperm motility [GO:0030317] acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; axonemal microtubule doublet inner sheath [GO:0160110]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017] EWIAHSEKLPR;TLVSQSNDLSSLRAK;VLQHVSEPQAHQESTR 3 18.9 0.78504 0.029621 0 0 0 0 0 8.96607 0 0 10.5769 0 0 0 Q96E40 SACA9_HUMAN Sperm acrosome-associated protein 9 SPACA9 C9orf9 Homo sapiens (Human) axoneme assembly [GO:0035082]; flagellated sperm motility [GO:0030317] acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; axonemal microtubule doublet inner sheath [GO:0160110]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017] EWIAHSEKLPR;TLVSQSNDLSSLRAK;VLQHGTT 3 19.6 0.96431 -1.1697 0 0 0 0 0 0 0 0 10.04 0 10.4441 10.7511 Q96E52 OMA1_HUMAN "Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)" OMA1 MPRP1 Homo sapiens (Human) cellular response to stress [GO:0033554]; cristae formation [GO:0042407]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; lipid metabolic process [GO:0006629]; mitochondrial protein processing [GO:0034982]; mitochondrial respiratory chain complex assembly [GO:0033108]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein autoprocessing [GO:0016540]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cristae formation [GO:1903850]; zymogen activation [GO:0031638] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] FQAAPVPLLLMILKPVQKLFAIIVGR;ITSKCTVWNDAFSRQLLIK;LFAIIVGRGIR;LIPQALK;MPEWLSTHPSHGNR 5 13.2 0.97355 -1.4049 0 0 0 4.54696 0 0 8.34518 8.43896 0 0 0 0 Q96E66 LRC51_HUMAN Leucine-rich repeat-containing protein 51 (Protein LRTOMT1) LRRC51 LRTOMT Homo sapiens (Human) cytoplasm [GO:0005737] SLTLHGNPMEEEKGYR 1 8.3 0.9171 -0.42528 0 0 0 0 9.05474 0 0 9.43459 0 0 0 0 Q96E93 KLRG1_HUMAN Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen) KLRG1 CLEC15A MAFA MAFAL Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] YGNHCYYFSVEEK 1 6.7 0.8809 -0.16905 0 0 0 0 0 8.9402 0 0 0 0 0 0 Q96EA4 SPDLY_HUMAN Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) SPDL1 CCDC99 Homo sapiens (Human) cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] enzyme binding [GO:0019899]; kinetochore binding [GO:0043515] NLPVDMQLK;QLKHQVDHQK 2 3.1 0.92148 -0.43921 0 10.3088 0 0 0 0 0 0 0 0 0 0 Q96EB1 ELP4_HUMAN Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein) ELP4 C11orf19 PAXNEB Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] phosphorylase kinase regulator activity [GO:0008607] MKIAWRYQLLPK;RKLFTIER 2 4.7 0.719 0.13509 0 0 0 0 0 7.58797 0 0 0 0 0 8.18105 Q96EB1 ELP4_HUMAN Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein) ELP4 C11orf19 PAXNEB Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] phosphorylase kinase regulator activity [GO:0008607] ATAFASR;MKIAWRYQLLPK 2 4 0.94124 -0.6013 0 0 0 0 0 11.4351 0 0 0 0 0 0 Q96EB6 SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] SIRT1 SIR2L1 Homo sapiens (Human) "angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA synthesis involved in DNA repair [GO:0000731]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; heterochromatin formation [GO:0031507]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage differentiation [GO:0030225]; maintenance of nucleus location [GO:0051658]; muscle organ development [GO:0007517]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902424]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of triglyceride biosynthetic process [GO:0010868]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein depropionylation [GO:0106230]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; rDNA heterochromatin formation [GO:0000183]; regulation of apoptotic process [GO:0042981]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of transcription by glucose [GO:0046015]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to leptin [GO:0044321]; response to oxidative stress [GO:0006979]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; white fat cell differentiation [GO:0050872]" chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; euchromatin [GO:0000791]; fibrillar center [GO:0001650]; heterochromatin [GO:0000792]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; rDNA heterochromatin [GO:0033553] "bHLH transcription factor binding [GO:0043425]; deacetylase activity [GO:0019213]; DNA-binding transcription factor binding [GO:0140297]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H3K deacetylase activity [GO:0141050]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K18 decrotonylase activity [GO:0170012]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; NAD+ binding [GO:0070403]; NAD-dependent histone decrotonylase activity [GO:0160012]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; NAD-dependent protein-lysine depropionylase activity [GO:0106231]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]" DLLPETIPPPELDDMTLWQIVINILSEPPKR;FIALSDKEGKLLR 2 5.9 0.97191 -1.3476 0 0 0 0 0 0 0 0 0 9.76749 9.981 0 Q96ED9 HOOK2_HUMAN Protein Hook homolog 2 (h-hook2) (hHK2) HOOK2 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; trans-Golgi network [GO:0005802] dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] EANEELRCAQLQPR;EYIEELEPPTDSSTARRIEELQHNLQK;LLQLVLGCAISCEKKQDHIQR;LQLENKR;QEEAMKAEKWLFECR;QEELQRHLEDANRAR 6 13.8 0.97086 -1.3432 0 0 12.835 10.7368 8.36824 0 0 0 0 0 8.18488 10.5391 Q96EE3 SEH1_HUMAN Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) SEH1L SEC13L SEH1 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; defense response to Gram-positive bacterium [GO:0050830]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031]; protein-containing complex localization [GO:0031503] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; Seh1-associated complex [GO:0035859] structural molecule activity [GO:0005198] VQIFEYNENTR 1 2.6 0.79193 0.016436 0 0 0 6.20752 0 0 0 0 0 0 0 0 Q96EF0 MTMR8_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 (EC 3.1.3.95) (Myotubularin-related protein 8) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR8 Homo sapiens (Human) negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of macroautophagy [GO:0016241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]" KQRAMLETDVHELEK;LNAMANRAAGKGYENEDNYANIR;LPITSLGCPLTLRCK 3 7.5 0.97976 -1.5651 0 0 0 0 0 0 0 12.0148 0 0 10.0965 0 Q96EG1 ARSG_HUMAN Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15) ARSG KIAA1001 UNQ839/PRO1777 Homo sapiens (Human) gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; homeostasis of number of cells [GO:0048872]; lysosome organization [GO:0007040]; neuron apoptotic process [GO:0051402]; retina development in camera-type eye [GO:0060041]; sulfur compound metabolic process [GO:0006790] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-sulfoglucosamine-3-sulfatase activity [GO:0033889] QGGSPAK 1 1.3 0.67665 0.16583 10.192 10.3901 0 0 5.45246 0 0 0 0 0 0 0 Q96EG3 ZN837_HUMAN Zinc finger protein 837 ZNF837 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" THSSAKPYACPLCEK;VHTGEKPYACPECGKAFNQR 2 6.6 0.91742 -0.40858 0 0 7.78686 0 0 0 0 0 0 0 0 7.7763 Q96EI5 TCAL4_HUMAN Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4) TCEAL4 NPD017 Homo sapiens (Human) nucleus [GO:0005634] KPEVTCTLEDKK;MENEEQPQDER;SLPQVSVR 3 8.7 0.91052 -0.28163 7.36833 0 0 0 0 0 0 0 9.85986 0 0 0 Q96EK4 THA11_HUMAN THAP domain-containing protein 11 THAP11 HRIHFB2206 Homo sapiens (Human) cell population proliferation [GO:0008283]; electron transport chain [GO:0022900]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of mitochondrial transcription [GO:1903108]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AGVSGCFSTFQPTTGHR 1 5.4 0.61983 0.17365 0 0 8.3366 0 0 0 0 0 0 0 0 0 Q96EK5 KBP_HUMAN KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein) KIFBP KBP KIAA1279 KIF1BP Homo sapiens (Human) central nervous system projection neuron axonogenesis [GO:0021952]; in utero embryonic development [GO:0001701]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; neuron projection maintenance [GO:1990535]; transport along microtubule [GO:0010970] cytoskeleton [GO:0005856]; mitochondrion [GO:0005739] kinesin binding [GO:0019894]; protein sequestering activity [GO:0140311] ELENLATSLEHYKFIVDYCEK;KELDEEESIR;KELENLATSLEHYK;VAIADRLR 4 6.4 0.98042 -1.6104 0 0 0 0 0 0 0 9.46968 9.68968 0 0 10.4972 Q96EK7 F120B_HUMAN Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B) FAM120B CCPG KIAA1838 Homo sapiens (Human) fat cell differentiation [GO:0045444]; peroxisome proliferator activated receptor signaling pathway [GO:0035357] nucleus [GO:0005634] AVVCKACMK;LEEILPLGPNKALFYK;LFHQKYLQSEK;QEVPTCTGPESRR;QYEHDQWRRY 5 6.5 0.97445 -3.7876 0 9.52871 11.9878 0 10.7473 8.21907 0 11.0887 0 3.97352 0 0 Q96EL2 RT24_HUMAN "Small ribosomal subunit protein uS3m (28S ribosomal protein S24, mitochondrial) (MRP-S24) (S24mt) (bMRP-47) (bMRP47)" MRPS24 HSPC335 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AASVCSGLLGPRVLSWSR 1 10.8 0.84726 -0.062559 0 0 0 0 0 0 0 0 0 0 0 10.2489 Q96EN8 MOCOS_HUMAN Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) MOCOS Homo sapiens (Human) Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; molybdopterin cofactor metabolic process [GO:0043545] cytosol [GO:0005829] lyase activity [GO:0016829]; molybdenum cofactor sulfurtransferase activity [GO:0008265]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] LSESRETK 1 0.9 0.91429 -0.33804 0 0 0 0 10.1038 0 0 0 0 0 0 0 Q96EN9 REX1B_HUMAN Required for excision 1-B domain-containing protein REX1BD C19orf60 Homo sapiens (Human) EEPAWPWKDAPIR;IHQLQAERAQGFR 2 14.5 0.95418 -0.8887 0 0 10.5863 0 0 0 0 9.62505 0 0 0 0 Q96EP0 RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) RNF31 ZIBRA Homo sapiens (Human) CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797] identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CKFSYALAR;ESLEPDAYALFHK;LTEGVLMRDPK 3 3.1 0.97793 -2.1566 0 0 10.9559 0 0 0 10.8071 11.7858 10.0404 0 0 10.2036 Q96EP1 CHFR_HUMAN E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR) CHFR RNF196 Homo sapiens (Human) cell division [GO:0051301]; meiotic spindle checkpoint signaling [GO:0044779]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634]; PML body [GO:0016605] metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] GVFLLSDYR;ITQDMLQPK 2 2.7 0.95392 -0.89629 0 0 0 0 0 10.7525 0 0 0 0 0 0 Q96EQ0 SGTB_HUMAN Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) SGTB SGT2 Homo sapiens (Human) post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; TRC complex [GO:0072380] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] DEGNNHMK 1 2.6 0.91365 -0.39033 0 0 0 0 0 0 0 0 0 0 7.55903 0 Q96ES6 MFSD3_HUMAN Major facilitator superfamily domain-containing protein 3 MFSD3 Homo sapiens (Human) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] HWKLLPLLRSVLR;LLPLLRSVLRFR 2 3.6 0.75255 0.076332 0 0 0 0 0 0 2.70337 0 0 8.05664 0 0 Q96ES7 SGF29_HUMAN SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) SGF29 CCDC101 Homo sapiens (Human) establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to endoplasmic reticulum stress [GO:0034976]; transcription initiation-coupled chromatin remodeling [GO:0045815] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] methylated histone binding [GO:0035064] GLYTTAK;ISPYYRTK;SEHNLVNIQKTHER;THERMQTENKISPYYR 4 11.9 0.91686 -0.42619 0 0 12.1189 9.80109 10.0297 0 10.1519 11.0768 0 11.8367 11.2009 10.2593 Q96EU6 RRP36_HUMAN Ribosomal RNA processing protein 36 homolog RRP36 C6orf153 HSPC253 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] DRRHLPLSK;TYKQLVAGNSPK 2 8.1 0.98087 -1.6243 0 0 0 0 14.4984 0 0 0 0 0 9.22458 0 Q96EU7 C1GLC_HUMAN "C1GALT1-specific chaperone 1 (C38H2-like protein 1) (C38H2-L1) (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone)" C1GALT1C1 COSMC HSPC067 MSTP143 UNQ273/PRO310 Homo sapiens (Human) platelet activation [GO:0030168]; platelet morphogenesis [GO:0036344]; protein O-linked glycosylation [GO:0006493] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] ETWTKHCDK;YFLLKKDPSQPFYLGHTIK 2 8.8 0.8604 -0.082653 0 0 0 0 0 7.63198 0 0 0 0 0 0 Q96EV2 RBM33_HUMAN RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RBM33 PRR8 Homo sapiens (Human) mRNA transport [GO:0051028]; regulation of mRNA stability [GO:0043488]; RNA export from nucleus [GO:0006405] cytoplasm [GO:0005737]; nucleus [GO:0005634] lncRNA binding [GO:0106222]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] ALKHLRQTR;AVAGSRSSQGK;EESDEEEEDDEESGR;GVGDQRRESTER;QGRYSSRR 5 4.7 0.97652 -5.3754 5.32884 0 0 0 0 8.45286 0 0 0 0 0 11.4575 Q96EV8 DTBP1_HUMAN Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) DTNBP1 BLOC1S8 My031 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; kidney development [GO:0001822]; melanosome organization [GO:0032438]; memory [GO:0007613]; negative regulation of dendritic spine morphogenesis [GO:0061002]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of receptor internalization [GO:0002092]; protein transmembrane transport [GO:0071806]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of signal transduction [GO:0009966]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041] axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672] CKHMQSQQLENYK 1 3.7 0.9239 -0.44957 0 0 0 0 0 0 0 0 0 0 5.87757 0 Q96EW2 HBAP1_HUMAN HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1) HSPBAP1 PASS1 Homo sapiens (Human) cytoplasm [GO:0005737] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706] TSEVVEIQALR 1 2.3 0.76436 0.067922 0 0 0 0 0 5.14478 0 0 0 0 0 0 Q96EX1 SIM12_HUMAN Small integral membrane protein 12 SMIM12 C1orf212 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] DKLEFAPKAVLNR 1 14.1 0.95921 -1.0415 0 0 0 0 0 10.4735 0 0 0 0 0 0 Q96EX2 RNFT2_HUMAN E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118) RNFT2 TMEM118 Homo sapiens (Human) positive regulation of ERAD pathway [GO:1904294] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GLPFILILLAKLCFQHK;YITIALKCLIVALPKIILAVK 2 8.6 0.53068 0.18665 0 0 6.9479 0 0 6.01981 0 0 0 0 0 0 Q96EX2 RNFT2_HUMAN E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118) RNFT2 TMEM118 Homo sapiens (Human) positive regulation of ERAD pathway [GO:1904294] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GLPFILILLAKLCFQHK;VSETLSKK 2 7.8 0.93006 -0.47919 0 0 11.4858 0 7.61139 7.00383 8.89545 0 0 0 0 0 Q96EY1 DNJA3_HUMAN "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) activation-induced cell death of T cells [GO:0006924]; cellular senescence [GO:0090398]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to type II interferon [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase-mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTPase regulator activity [GO:0030695]; Hsp70 protein binding [GO:0030544]; IkappaB kinase complex binding [GO:0106137]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; type II interferon receptor binding [GO:0005133]; unfolded protein binding [GO:0051082] AARCSTR;EFTVNIMDTCERCNGKGNEPGTK;GSIIISPCVVCR;WLLVVVGTPRLPAISGRGARPPR 4 13.5 0.97859 -2.1488 9.14481 0 0 8.89194 0 4.68122 0 0 0 5.58743 6.3209 0 Q96EY4 TMA16_HUMAN Translation machinery-associated protein 16 TMA16 C4orf43 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] preribosome binding [GO:1990275] VIHPYSRKAAQITR 1 6.9 0.95494 -0.93765 0 0 0 0 0 0 0 15.8481 15.9488 15.0074 0 0 Q96EY7 PTCD3_HUMAN "Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15)" PTCD3 MRPS39 TRG15 Homo sapiens (Human) mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] LGQPLTGR;VMSDFAINQEQK 2 2.9 0.95549 -0.82838 11.1068 12.6421 0 0 0 8.87952 0 7.26087 0 0 0 0 Q96EY8 MMAB_HUMAN Corrinoid adenosyltransferase MMAB (EC 2.5.1.-) (ATP:co(I)rrinoid adenosyltransferase MMAB) (Methylmalonic aciduria type B protein) MMAB Homo sapiens (Human) cobalamin metabolic process [GO:0009235] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "ATP binding [GO:0005524]; cobalamin binding [GO:0031419]; corrinoid adenosyltransferase activity [GO:0008817]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]" AVCRRAER;ISSALHFCR;ISSALHFCRAVCR 3 6.8 0.97628 -2.2627 0 12.4184 0 9.66906 0 0 0 0 0 0 0 0 Q96F05 CK024_HUMAN Uncharacterized protein C11orf24 (Protein DM4E3) C11orf24 FP2568 UNQ1872/PRO4315 Homo sapiens (Human) Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] MWKGLVKR 1 1.8 0.87161 -0.095167 0 0 0 0 0 0 0 0 0 7.89603 7.57516 0 Q96F07 CYFP2_HUMAN Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) CYFIP2 KIAA1168 PIR121 Homo sapiens (Human) activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; cell-cell adhesion [GO:0098609]; dendrite extension [GO:0097484]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of proteolysis [GO:0045862]; regulation of actin filament polymerization [GO:0030833]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCAR complex [GO:0031209]; synapse [GO:0045202] small GTPase binding [GO:0031267] RFDLFDFCYHLLKVQR;TLIEVMPK 2 1.9 0.92903 -0.46102 0 0 4.3826 0 0 0 0 0 7.98294 0 0 0 Q96F44 TRI11_HUMAN E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11) TRIM11 RNF92 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] VPGLVETLR 1 1.9 0.90984 -0.28307 0 0 0 0 0 0 0 0 0 10.9271 0 0 Q96F63 CCD97_HUMAN Coiled-coil domain-containing protein 97 CCDC97 Homo sapiens (Human) nucleus [GO:0005634] LILREEFTSRMHQR 1 4.1 0.54856 0.18382 0 0 0 0 0 0 0 0 0 0 9.85426 0 Q96F81 DISP1_HUMAN Protein dispatched homolog 1 DISP1 DISPA Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; peptide transport [GO:0015833]; protein homotrimerization [GO:0070207]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020] peptide transmembrane transporter activity [GO:1904680] ATLANYPFKYADEQAK;LVTWNNMVK;TCCDPENK;VLPCIVIK 4 2.7 0.97872 -1.9048 0 0 0 0 6.31116 0 0 0 0 5.02317 0 0 Q96F85 CNRP1_HUMAN CB1 cannabinoid receptor-interacting protein 1 (CRIP-1) CNRIP1 C2orf32 Homo sapiens (Human) negative regulation of signaling receptor activity [GO:2000272]; regulation of signaling receptor activity [GO:0010469] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] type 1 cannabinoid receptor binding [GO:0031718] SLMWVNK;VEVKIKPSTLQVENISIGGVLVPLELK 2 20.7 0.94604 -0.65497 0 0 0 0 0 0 0 0 0 0 5.94753 0 Q96FA3 PELI1_HUMAN E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) PELI1 PRISM Homo sapiens (Human) DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of necroptotic process [GO:0060544]; regulation of Toll signaling pathway [GO:0008592]; response to dsRNA [GO:0043331]; response to lipopolysaccharide [GO:0032496]; T cell proliferation [GO:0042098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450] APVKYGELIVLGYNGSLPNGDRGR;FACRIICERNPPFTAR 2 9.6 0.73948 0.10314 0 0 0 0 8.61508 0 0 0 0 0 0 11.7845 Q96FB5 MT25B_HUMAN Methyltransferase-like protein 25B (Protein RRNAD1) (Ribosomal RNA adenine dimethylase domain-containing protein 1) METTL25B C1orf66 RRNAD1 CGI-41 Homo sapiens (Human) membrane [GO:0016020] "rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" AQRLDQELLQALEKEEK;IEEYVQRGLQR;SIEGDQRLVER 3 8.2 0.95488 -0.95018 0 0 0 7.82553 3.09184 0 0 0 3.36163 0 0 10.6294 Q96FC7 PHIPL_HUMAN Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL KIAA1796 UNQ6309/PRO20934 Homo sapiens (Human) cytoplasm [GO:0005737] AVPLPMTVR;FSVFYRNQHK;ITHYFIDLNKK 3 8.6 0.9514 -0.69206 0 0 10.7907 0 0 0 0 0 0 6.13933 0 5.29333 Q96FC9 DDX11_HUMAN ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) DDX11 CHL1 CHLR1 KRG2 Homo sapiens (Human) cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; establishment of sister chromatid cohesion [GO:0034085]; G-quadruplex DNA unwinding [GO:0044806]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]" DLVDRLKAEQAR;IFQEPKSAHQVEQVLLAYSR;IGIFESPTGTGK;ILCNLCGVVPGGVVCFFPSYEYLR 4 7 0.88165 -0.16803 14.6593 13.8483 13.7422 11.6313 11.4995 11.5702 14.6918 0 15.0443 14.5239 14.3792 13.6315 Q96FC9 DDX11_HUMAN ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) DDX11 CHL1 CHLR1 KRG2 Homo sapiens (Human) cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; establishment of sister chromatid cohesion [GO:0034085]; G-quadruplex DNA unwinding [GO:0044806]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]" DLVDRLKAEQAR;IGIFESPTGTGK;RELPQMIFQEPKSAHQVEQVLLAYSR 3 5.8 0.96469 -1.1189 0 0 0 9.38907 0 0 0 0 0 0 0 0 Q96FE5 LIGO1_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A) LINGO1 LERN1 LRRN6A UNQ201/PRO227 Homo sapiens (Human) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154] LDISENK;LNFNRQQPTCATPEFVQGK;LTVFPDGTLEVR;SLEVGDNDLVYISHR;TLIIATTMGFISFLGVVLFCLVLLFLWSR 5 13.2 0.91829 -0.40365 7.95391 4.6684 0 0 0 0 0 11.3805 0 0 5.07921 0 Q96FE7 P3IP1_HUMAN Phosphoinositide-3-kinase-interacting protein 1 (PI3K-interacting protein 1) (Kringle domain-containing protein HGFL) PIK3IP1 HGFL Homo sapiens (Human) negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898] extracellular space [GO:0005615]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; signaling receptor binding [GO:0005102] MNSKEKK;QDVENQLKM;RKQDVENQLK 3 7.7 0.9147 -0.33103 0 0 0 0 0 0 11.1821 0 9.89485 0 11.9037 0 Q96FF7 MISP3_HUMAN Uncharacterized protein MISP3 (MISP family member 3) MISP3 Homo sapiens (Human) KVSENGLEQEER;QRRSVYGTAEFK;VRPVLNLPGPGPALPR 3 18.3 0.91112 -0.32435 0 0 0 9.24072 8.36256 9.73669 0 0 0 8.01223 0 9.39953 Q96FF9 CDCA5_HUMAN Sororin (Cell division cycle-associated protein 5) (p35) CDCA5 Homo sapiens (Human) cell division [GO:0051301]; double-strand break repair [GO:0006302]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of exit from mitosis [GO:0031536] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; protein-containing complex binding [GO:0044877] ENEPPGRELTK;ENEPPGRELTKEDLFK 2 6.3 0.34337 0.23798 10.3167 0 0 0 0 0 0 0 15.1049 0 0 0 Q96FG2 ELMD3_HUMAN ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29) ELMOD3 RBED1 RBM29 PP4068 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; gene expression [GO:0010467]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; kinocilium [GO:0060091]; stereocilium [GO:0032420] LLKTLELYLARVSK 1 3.7 0.76797 0.059768 0 0 0 0 0 0 0 0 0 0 4.61094 0 Q96FG2 ELMD3_HUMAN ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29) ELMOD3 RBED1 RBM29 PP4068 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; gene expression [GO:0010467]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; kinocilium [GO:0060091]; stereocilium [GO:0032420] LNAQCPRSREPK 1 3.1 0.76867 0.056906 0 0 0 0 7.40438 0 0 0 0 0 0 0 Q96FI4 NEIL1_HUMAN Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) NEIL1 Homo sapiens (Human) "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; depyrimidination [GO:0045008]; negative regulation of nuclease activity [GO:0032074]; response to oxidative stress [GO:0006979]" centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; zinc ion binding [GO:0008270]" ALVFGGCVEKSSVSR;GRQAASGHCRPR 2 6.9 0.94433 -0.62366 0 0 0 0 0 8.61563 0 0 0 0 2.5859 0 Q96FJ0 STALP_HUMAN AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) STAMBPL1 AMSHLP KIAA1373 Homo sapiens (Human) cellular response to L-leucine [GO:0071233]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020] K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492] GFHPHTK;HVLVKDIKIIVLDLR;LKEIAFPR;QELARGQMR 4 8.9 0.97494 -3.2617 0 0 0 12.0406 6.14757 0 0 7.11551 7.24641 13.083 12.8065 0 Q96FK6 WDR89_HUMAN WD repeat-containing protein 89 WDR89 C14orf150 MSTP050 Homo sapiens (Human) corpus callosum development [GO:0022038]; ventricular system development [GO:0021591] ESMKIASSVHQRVR;VRVHSNDSYKR 2 5.9 0.74476 0.092906 0 3.61847 0 9.62987 10.4504 0 0 0 9.86779 0 0 0 Q96FL8 S47A1_HUMAN Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) SLC47A1 MATE1 Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; organic cation transport [GO:0015695]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; putrescine transmembrane transporter activity [GO:0015489]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] GLLLLGVFLILLVGILVR;GLLLLGVFLILLVGILVRFYVR 2 3.9 0.71638 0.13834 0 7.23946 0 0 0 6.15113 0 0 7.05994 5.06359 0 5.96738 Q96FL8 S47A1_HUMAN Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) SLC47A1 MATE1 Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; organic cation transport [GO:0015695]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; putrescine transmembrane transporter activity [GO:0015489]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] GLLLLGVFLILLAGVR;QLVLRRGLLLLGVFLILLAGVR;RGLLLLGVFLILLAGVR 3 3.8 0.42634 0.19688 5.61474 5.68507 0 0 0 0 0 3.71425 0 3.24629 0 0 Q96FL9 GLT14_HUMAN Polypeptide N-acetylgalactosaminyltransferase 14 (EC 2.4.1.41) (Polypeptide GalNAc transferase 14) (GalNAc-T14) (pp-GaNTase 14) (Protein-UDP acetylgalactosaminyltransferase 14) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14) GALNT14 UNQ2434/PRO4994 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] CLESQRQNNQETPNLK;HLSVLNRTPTHLIR;NLRCQSFK;QLIKLPKVK 4 9.1 0.97377 -2.4628 0 0 0 0 0 0 0 10.2584 4.88709 0 8.72369 9.81064 Q96FM1 PGAP3_HUMAN Post-GPI attachment to proteins factor 3 (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1) PGAP3 CAB2 PERLD1 UNQ546/PRO1100 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "hydrolase activity, acting on ester bonds [GO:0016788]" VPQFHGKWPFSR 1 4 0.91587 -0.43284 0 5.38798 0 0 0 0 0 0 0 0 0 10.8293 Q96FN5 KIF12_HUMAN Kinesin-like protein KIF12 KIF12 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AQRVTTRPQAPK;SQPPCSEGARSPGQVLPPH 2 4.8 0.95434 -0.88618 0 0 0 0 0 0 2.68838 0 0 4.73107 0 0 Q96FQ6 S10AG_HUMAN Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) S100A16 S100F AAG13 Homo sapiens (Human) response to calcium ion [GO:0051592] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] AVIVLVENFYKYVSKYSLVK;KAADKLIQNLDANHDGR;LIHEQEQQSSS 3 46.6 0.86946 -0.096557 0 0 0 0 0 0 0 11.1687 0 0 10.1167 0 Q96FS4 SIPA1_HUMAN Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) SIPA1 SPA1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cellular response to water deprivation [GO:0042631]; cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096] GNPAPELR;GTISEDALPPGPPR;LLEHVAPQLSPSCLR;LQEDLQK;TLLTLDEQVLSFQR 5 5.6 0.96202 -1.0693 11.4662 0 11.2946 0 0 0 11.161 0 0 9.64676 0 0 Q96FV0 LRC46_HUMAN Leucine-rich repeat-containing protein 46 LRRC46 Homo sapiens (Human) MFHTLDELQTVRLDREGITTIR 1 6.9 0.97596 -1.4757 0 0 0 0 0 0 0 11.0244 0 0 0 0 Q96FV2 SCRN2_HUMAN Secernin-2 SCRN2 Homo sapiens (Human) proteolysis [GO:0006508] extracellular exosome [GO:0070062] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] FQTQVDR;GQQLQQK 2 3.3 0.96433 -1.1652 0 10.1246 0 0 0 0 0 0 0 0 0 0 Q96FV3 TSN17_HUMAN Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17) TSPAN17 FBXO23 TM4SF17 Homo sapiens (Human) establishment of protein localization to organelle [GO:0072594]; regulation of membrane protein ectodomain proteolysis [GO:0051043] plasma membrane [GO:0005886] enzyme binding [GO:0019899] AVKANWSK;HQHFQEPEVGCCGK 2 6.7 0.91181 -0.32374 0 0 0 4.71078 0 0 0 0 11.2856 0 0 0 Q96FV9 THOC1_HUMAN THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84) THOC1 HPR1 Homo sapiens (Human) apoptotic process [GO:0006915]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] DNA binding [GO:0003677]; RNA binding [GO:0003723] FTKSTREALNNK;ILAPYLEMKDSEIR;LLARRSPHFFQPTNQQFK;SPTPPLFSLPEARTR 4 9 0.96357 -1.1094 0 0 0 0 9.66637 0 0 9.62042 0 0 0 11.769 Q96FW1 OTUB1_HUMAN Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) OTUB1 OTB1 OTU1 HSPC263 Homo sapiens (Human) adaptive immune response [GO:0002250]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105] MKPSWLSRTEFSKR 1 4.4 0.86474 -0.087652 0 0 0 0 0 0 0 0 0 0 0 8.25087 Q96FX7 TRM61_HUMAN tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) TRMT61A C14orf172 TRM61 Homo sapiens (Human) mRNA processing [GO:0006397]; tRNA methylation [GO:0030488] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] SFVAYEELIK 1 3.5 0.77388 0.047003 0 0 0 0 0 0 0 0 0 0 0 10.0737 Q96FX8 PERP_HUMAN p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW) PERP KCP1 KRTCAP1 PIGPC1 THW Homo sapiens (Human) activation of cysteine-type endopeptidase activity [GO:0097202]; amelogenesis [GO:0097186]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; heterotypic cell-cell adhesion [GO:0034113]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; mammary gland duct morphogenesis [GO:0060603]; Notch signaling pathway [GO:0007219]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell apoptotic process [GO:0070234]; tissue homeostasis [GO:0001894] cell-cell junction [GO:0005911]; desmosome [GO:0030057]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] CSQEGGGSGSYEEGCQSLMEYAWGR 1 13 0.71176 0.15167 0 0 0 0 0 0 0 0 0 0 7.60696 0 Q96FZ7 CHMP6_HUMAN Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20) CHMP6 VPS20 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex assembly [GO:1904902]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] AILQLKQQRDK 1 5.5 0.86408 -0.089784 0 0 0 0 0 0 0 0 0 0 0 5.43256 Q96G01 BICD1_HUMAN Protein bicaudal D homolog 1 (Bic-D 1) BICD1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; intracellular mRNA localization [GO:0008298]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; RNA processing [GO:0006396]; stress granule assembly [GO:0034063]; viral process [GO:0016032] centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; proteinase activated receptor binding [GO:0031871]; small GTPase binding [GO:0031267]; structural constituent of cytoskeleton [GO:0005200] GLQSSKELKAELDGEK;KEPMNIYNLNAIIR 2 3.1 0.95571 -0.85613 0 0 0 0 0 9.78293 0 0 0 9.33374 0 0 Q96G03 PGM2_HUMAN Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2) PGM2 MSTP006 Homo sapiens (Human) glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; purine ribonucleoside salvage [GO:0006166] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973] QLIDQGK;TVLFAFEEAIGK 2 6.5 0.95984 -1.0519 12.7876 0 0 0 0 0 9.17185 0 0 0 0 0 Q96G21 IMP4_HUMAN U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4) IMP4 BXDC4 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] fibrillar center [GO:0001650]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome [GO:0030684]; small-subunit processome [GO:0032040] rRNA primary transcript binding [GO:0042134]; snoRNA binding [GO:0030515] LVFPGAQRMNRGR;NVELTEVGPRFELKLYMIR;WHPYTNTARKR 3 14.8 0.97575 -1.4612 0 0 0 0 0 0 0 0 0 10.11 0 7.72021 Q96G28 CFA36_HUMAN Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) CFAP36 CCDC104 UNQ163/PRO189 Homo sapiens (Human) axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; motile cilium [GO:0031514]; nucleus [GO:0005634] GPDWSIPILDFVEQKCEVNCK;LMSMRKDMR;VERSETSSLPQK 3 11.4 0.95999 -1.0496 0 0 4.87745 9.45107 9.74705 0 0 0 11.2574 0 0 0 Q96G42 KLD7B_HUMAN Kelch domain-containing protein 7B KLHDC7B Homo sapiens (Human) SSDIVALGGFLYR 1 2.2 0.89768 -0.23832 0 0 0 0 0 0 0 0 0 8.05658 0 0 Q96G46 DUS3L_HUMAN tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) DUS3L Homo sapiens (Human) mRNA processing [GO:0006397]; regulation of translation [GO:0006417]; tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; mRNA dihydrouridine synthase activity [GO:0106414]; RNA binding [GO:0003723]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine47 synthase activity [GO:0102265] FLLEWLSFLCR 1 1.7 0.78173 0.021357 0 0 0 0 0 0 0 0 0 0 9.24236 0 Q96G61 NUD11_HUMAN "Diphosphoinositol polyphosphate phosphohydrolase 3-beta (DIPP-3-beta) (DIPP3-beta) (hDIPP3beta) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 11) (Nudix motif 11) (hAps1)" NUDT11 APS1 DIPP3B Homo sapiens (Human) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872] EVYEEAGVK;MKCKPNQTR 2 11 0.97797 -1.5027 0 0 0 0 0 0 0 10.8492 11.4699 0 0 0 Q96G74 OTUD5_HUMAN OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) OTUD5 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of immune response [GO:0050776]; response to lipopolysaccharide [GO:0032496] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578] GPSQPRK;NIHYNSVVNPNK 2 3.3 0.95177 -0.70027 0 0 0 0 0 8.65234 10.7237 10.5203 0 0 7.94626 0 Q96G75 RMD5B_HUMAN E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B) RMND5B UNQ2508/PRO5996 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] SLEELLHYVGQLR 1 3.3 0.78691 0.017861 10.2444 0 0 0 0 0 0 0 0 0 0 0 Q96GA3 LTV1_HUMAN Protein LTV1 homolog LTV1 C6orf93 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome biogenesis [GO:0042254] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" IDNEERRAEQR;SENEDDSEWEDVDDEK 2 5.7 0.95875 -1.0326 0 0 0 0 2.75564 0 0 0 0 0 0 11.3581 Q96GC6 ZN274_HUMAN Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2) ZNF274 ZKSCAN19 SP2114 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleolus [GO:0005730] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" IFRNPRYFSVHK;SAISQHLR;THTGERPYACNKCGKAFTQSSHLIGHQR 3 7.4 0.98023 -1.5584 0 0 0 5.45923 0 0 0 0 0 8.89406 0 0 Q96GC9 VMP1_HUMAN Vacuole membrane protein 1 (Transmembrane protein 49) VMP1 TDC1 TMEM49 HSPC292 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; autophagy [GO:0006914]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; Golgi organization [GO:0007030]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; organelle localization by membrane tethering [GO:0140056]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896] autophagosome membrane [GO:0000421]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] AIIKMHIQKIFVIITFSK 1 4.4 0.86519 -0.086975 0 0 8.32876 3.46114 0 0 0 0 0 0 0 9.14563 Q96GD4 AURKB_HUMAN Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 Homo sapiens (Human) cell cycle G2/M phase transition [GO:0044839]; cellular response to UV [GO:0034644]; cleavage furrow formation [GO:0036089]; midbody abscission [GO:0061952]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic sister chromatid biorientation [GO:1990758]; mitotic spindle assembly [GO:0090307]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of cytokinesis [GO:0032466]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cytokinesis [GO:0032467]; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of telomere maintenance [GO:0032206]; post-translational protein modification [GO:0043687]; protein localization to kinetochore [GO:0034501]; regulation of chromosome segregation [GO:0051983]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; repair of mitotic kinetochore microtubule attachment defect [GO:0140273]; spindle organization [GO:0007051] "centrosome [GO:0005813]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]" ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] IYLILEYAPR;KVIHRDIKPENLLLGLK;LYNYFYDR 3 10.2 0.95809 -1.0147 0 0 6.82286 4.13488 0 0 0 0 0 0 0 0 Q96GE4 CEP95_HUMAN Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) CEP95 CCDC45 CEP45 Homo sapiens (Human) centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] DLRNYAKEK;HQDELDSMENYYK;ISETSHEKSETEQYFK;LGDTAHTFSLR;LTEQELHDVSEK;QRLTQSK;TRKPPKGK 7 9.3 0.98095 -1.6939 0 0 0 0 9.42274 0 10.7628 10.9355 1.84904 6.90953 0 10.8123 Q96GE5 ZN799_HUMAN Zinc finger protein 799 (Zinc finger protein 842) ZNF799 ZNF842 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFSFYSSYLRHERTHTGEK;AFVYPSVFQRHEK;ALSHSSSFR;DGTQCGETSSQIQDSIVTK;EEWALLGPCQKNLYKDVMQETIR 5 12.9 0.94223 -0.59582 8.70822 9.83333 0 8.51483 0 0 0 0 7.52113 6.13615 4.73438 0 Q96GE6 CALL4_HUMAN Calmodulin-like protein 4 (Serologically defined breast cancer antigen NY-BR-20) CALML4 Homo sapiens (Human) brush border assembly [GO:1904970]; microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; microvillus [GO:0005902] calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; myosin head/neck binding [GO:0032028] LEAGGKGTERGSGSSKPTGSSR;LTSLGEK 2 14.8 0.86497 -0.087715 0 0 0 0 0 0 0 0 0 0 8.18289 0 Q96GG9 DCNL1_HUMAN DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO Homo sapiens (Human) positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434]; regulation of protein ubiquitination [GO:0031396] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182] FLDLWNKFLLEHHK;LEQLYNRYK 2 8.9 0.95571 -0.9673 0 0 0 0 3.47807 0 0 11.2434 0 0 0 0 Q96GJ1 TRM2B_HUMAN tRNA (uracil-5-)-methyltransferase homolog B (EC 2.1.1.35) (TRM2 homolog B) (rRNA (uracil-5-)-methyltransferase TRMT2B) (EC 2.1.1.-) TRMT2B CXorf34 Homo sapiens (Human) tRNA processing [GO:0008033] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [GO:0030697]" LSYEEQLKPVINGYR 1 3.3 0.64135 0.17258 0 0 0 7.32975 0 0 0 0 0 0 0 0 Q96GK7 FAH2A_HUMAN "Oxaloacetate tautomerase FAHD2A, mitochondrial (EC 5.3.2.2) (Fumarylacetoacetate hydrolase domain-containing protein 2A)" FAHD2A CGI-105 Homo sapiens (Human) oxaloacetate metabolic process [GO:0006107] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; oxaloacetate tautomerase activity [GO:0050163] RALAAQLPVLPR 1 3.8 0.74014 0.10338 0 0 0 6.1494 0 0 0 0 0 0 0 0 Q96GM1 PLPR2_HUMAN Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4) PLPPR2 LPPR2 PRG4 Homo sapiens (Human) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] plasma membrane [GO:0005886] phosphatidate phosphatase activity [GO:0008195] KLLLPTPLLR 1 2.3 0.74574 0.093323 0 0 0 0 0 0 0 0 0 4.29205 0 0 Q96GM5 SMRD1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit) SMARCD1 BAF60A Homo sapiens (Human) cellular response to fatty acid [GO:0071398]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LDQTIMRK;TMTDVVGNPEEERR 2 4.3 0.35352 0.23422 0 8.39729 0 0 0 0 0 0 0 0 0 0 Q96GN5 CDA7L_HUMAN Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) CDCA7L HR1 JPO2 R1 Homo sapiens (Human) positive regulation of cell population proliferation [GO:0008284]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GICNCSYCR;QDVRFHSK 2 3.8 0.88208 -0.16733 6.61521 8.57061 0 0 0 0 0 0 0 0 0 0 Q96GP6 SREC2_HUMAN Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] focal adhesion [GO:0005925]; membrane [GO:0016020] scavenger receptor activity [GO:0005044] CDQPCATGFYGEGCSHRCPPCR;CDRYCQCFRGR;HSAAAAGR;MEGAGPR;SCNNQCACNSSPCEQQSGRCQCR;SREAAGELGRAGAPTL;VSWIHGK 7 10.8 0.97301 -2.6606 0 0 6.54467 0 6.85611 9.20865 0 9.32751 0 0 0 0 Q96GQ5 RUSF1_HUMAN RUS family member 1 RUSF1 C16orf58 Homo sapiens (Human) membrane [GO:0016020] CIVSVAGGATRAALTVHQARR;GCRAAADGSLQWEVGGWRWWGLSR 2 9.6 0.97968 -2.0431 0 0 0 0 0 0 0 10.1895 0 0 9.27766 0 Q96GQ5 RUSF1_HUMAN RUS family member 1 RUSF1 C16orf58 Homo sapiens (Human) membrane [GO:0016020] CLMGEGRMGRWGSWMTGYR 1 9.2 0.50085 0.18915 0 0 0 0 0 0 12.08 0 0 0 0 0 Q96GQ7 DDX27_HUMAN Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) DDX27 cPERP-F RHLP HSPC259 PP3241 Homo sapiens (Human) rRNA processing [GO:0006364] chromosome [GO:0005694]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AITAMGFK;ALQEFDLALR;APVKARILPQDVILK;MEKDVYAVLQLEAEEK 4 6.2 0.95443 -0.89876 0 15.0608 15.1111 13.743 0 0 14.749 14.8791 14.9209 13.32 0 15.4831 Q96GR2 ACBG1_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin) ACSBG1 BGM KIAA0631 LPD Homo sapiens (Human) long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; myelination [GO:0042552]; response to glucocorticoid [GO:0051384]; very long-chain fatty acid metabolic process [GO:0000038] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] QALGFAK;RVNMNAAARPYHIQK 2 3 0.90715 -0.30489 0 0 0 9.23723 0 0 0 0 0 0 0 0 Q96GS4 BORC6_HUMAN BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) BORCS6 C17orf59 Homo sapiens (Human) lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196] BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574] identical protein binding [GO:0042802] TLEVLEALCK 1 2.8 0.88284 -0.17838 0 0 0 0 0 0 10.4925 0 0 0 0 0 Q96GS6 AB17A_HUMAN Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22) ABHD17A C19orf27 FAM108A1 Homo sapiens (Human) negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175] dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] ELDTIEVFPTK;QGHQAQGGHPQLAWVGR 2 7.8 0.65954 0.16918 0 0 0 0 0 0 0 0 0 0 6.1633 0 Q96GS6 AB17A_HUMAN Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22) ABHD17A C19orf27 FAM108A1 Homo sapiens (Human) negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175] dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] ELDTIEVFPTK;VAFPDTKKTYCFDAFPK 2 11.9 0.91769 -0.42039 0 0 0 0 0 0 0 7.85947 0 0 0 0 Q96GV9 MACIR_HUMAN Macrophage immunometabolism regulator MACIR C5orf30 Homo sapiens (Human) cilium assembly [GO:0060271]; epithelial cell migration [GO:0010631]; fibroblast migration [GO:0010761]; inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of inflammatory response [GO:0050728]; protein transport [GO:0015031] ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737] CTGGEESK;MIKEPADTEVLQYQLQHLTLR 2 14.1 0.95532 -0.82929 0 0 0 0 4.08551 0 6.61039 0 0 0 0 0 Q96GW7 PGCB_HUMAN Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7) BCAN BEHAB CSPG7 UNQ2525/PRO6018 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synapse maturation [GO:0060074] extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; side of membrane [GO:0098552]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] EAEVLVARGVR;LTLEEAR;LTLEEARAYCQER;VKVNEAYRFR 4 3.7 0.97283 -2.9533 0 10.6083 0 0 0 9.01173 4.46002 0 0 0 11.3399 0 Q96GW9 SYMM_HUMAN "Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)" MARS2 Homo sapiens (Human) methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825] LGPETGLLFPRLDQSR 1 2.7 0.95159 -0.70097 0 0 0 0 0 0 0 0 0 0 0 8.06318 Q96GX5 GWL_HUMAN Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) MASTL GW GWL THC2 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; female meiosis II [GO:0007147]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DPTAGSK;ENIVNSFTDK;LTDFGLSKVTLNR;VTLNRDINMMDILTTPSMAKPR 4 5.3 0.93642 -0.52527 0 4.74599 0 0 0 0 0 8.98712 0 7.8824 0 8.39785 Q96GX9 MTNB_HUMAN Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) APIP CGI-29 Homo sapiens (Human) apoptotic process [GO:0006915]; L-methionine salvage from methylthioadenosine [GO:0019509]; negative regulation of apoptotic process [GO:0043066]; protein homotetramerization [GO:0051289]; pyroptotic inflammatory response [GO:0070269]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; methylthioribulose 1-phosphate dehydratase activity [GO:0046570]; zinc ion binding [GO:0008270] MSGCDAREGDCCSR;SGCDAREGDCCSR 2 5.8 0.97402 -1.4043 0 0 0 0 0 0 6.68089 0 0 0 0 0 Q96GY0 ZC21A_HUMAN Zinc finger C2HC domain-containing protein 1A ZC2HC1A C8orf70 FAM164A CGI-62 Homo sapiens (Human) metal ion binding [GO:0046872] FCCECGIR 1 2.5 0.91511 -0.39033 0 0 0 0 0 0 0 0 0 6.11249 0 0 Q96H12 MSD3_HUMAN Myb/SANT-like DNA-binding domain-containing protein 3 MSANTD3 C9orf30 L8 Homo sapiens (Human) MQNNEIIKPAK;SLELSIILSGTW 2 14.5 0.92191 -0.44336 0 0 0 0 0 0 0 0 0 0 8.94761 0 Q96H15 TIMD4_HUMAN T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4) TIMD4 TIM4 Homo sapiens (Human) "apoptotic cell clearance [GO:0043277]; cytoskeletal rearrangement involved in phagocytosis, engulfment [GO:0060097]" extracellular region [GO:0005576]; plasma membrane [GO:0005886] phosphatidylserine binding [GO:0001786] EPLILWLMIEFWWLYLTPVTSETVVTEVLGHR;IEVPGWFNDVK;TATTTTR 3 13.2 0.94438 -0.64744 0 6.82311 0 8.5196 0 2.22642 11.2451 11.0796 8.9321 0 0 0 Q96H20 SNF8_HUMAN Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) SNF8 EAP30 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667] channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] GVGAGAIAK 1 3.5 0.9293 -0.46819 0 0 0 0 0 0 0 8.27011 0 0 0 0 Q96H22 CENPN_HUMAN Centromere protein N (CENP-N) (Interphase centromere complex protein 32) CENPN C16orf60 ICEN32 BM-309 Homo sapiens (Human) CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DLYLLFVPLYPR 1 3.4 0.80923 0.0093225 0 0 0 0 0 4.66015 0 0 0 0 0 0 Q96H35 RBM18_HUMAN Probable RNA-binding protein 18 (RNA-binding motif protein 18) RBM18 Homo sapiens (Human) cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] RTTPYSRTAWK 1 5.8 0.95409 -0.91646 0 0 0 0 0 0 0 11.7844 0 0 0 0 Q96H40 ZN486_HUMAN Zinc finger protein 486 (KRAB domain only protein 2) ZNF486 KRBO2 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] extracellular exosome [GO:0070062]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDTGEKPYKCEECGKAFNR;VFHQFSNSK 2 6 0.95244 -0.67255 0 0 0 0 7.99673 0 0 0 0 0 0 0 Q96H55 MYO19_HUMAN Unconventional myosin-XIX (Myosin head domain-containing protein 1) MYO19 MYOHD1 Homo sapiens (Human) actin filament organization [GO:0007015]; mitochondrion migration along actin filament [GO:0034642]; mitocytosis [GO:0160040]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial fission [GO:0090140]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; plus-end directed microfilament motor activity [GO:0060002] LVVWACLQLPR;QQQVFRKPCAR;SWLTRKHIQR 3 3.3 0.92998 -0.47471 0 0 0 0 10.5851 0 0 0 0 10.9508 0 0 Q96H72 S39AD_HUMAN Zinc transporter ZIP13 (LIV-1 subfamily of ZIP zinc transporter 9) (LZT-Hs9) (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13) SLC39A13 ZIP13 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; connective tissue development [GO:0061448]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803]; zinc ion transmembrane transporter activity [GO:0005385] MPGCPCPGCGMAGPR 1 4 0.78083 0.021565 0 0 0 0 0 0 4.51412 0 0 0 0 0 Q96H79 ZCCHL_HUMAN Zinc finger CCCH-type antiviral protein 1-like ZC3HAV1L C7orf39 Homo sapiens (Human) cytosol [GO:0005829] AEPTVCSFLTK;GEALYGYCNLKDK 2 8 0.084375 0.38675 0 11.612 3.86453 10.5063 10.4069 10.3854 0 11.4802 11.0062 11.218 11.1883 0 Q96H86 ZN764_HUMAN Zinc finger protein 764 ZNF764 Homo sapiens (Human) cellular response to glucocorticoid stimulus [GO:0071385]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator activity [GO:0003712]" EPGAVSFADVAVYFCR 1 3.9 0.77834 0.034988 0 0 0 0 0 0 0 0 0 7.00708 0 0 Q96H96 COQ2_HUMAN "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (COQ2 homolog) (hCOQ2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" COQ2 CL640 Homo sapiens (Human) glycerol metabolic process [GO:0006071]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] 4-hydroxybenzoate polyprenyltransferase activity [GO:0008412]; prenyltransferase activity [GO:0004659] TLGLIVFLGIVLGNLWK 1 4.6 0.67167 0.16808 0 0 3.61117 0 0 0 0 0 0 0 0 0 Q96HA1 P121A_HUMAN Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) POM121 KIAA0618 NUP121 POM121A Homo sapiens (Human) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] KLLPAVRAQGLPR 1 1.3 0.87169 -0.095379 0 0 0 0 0 0 0 4.33643 0 0 0 0 Q96HA4 CA159_HUMAN Uncharacterized protein C1orf159 C1orf159 UNQ2998/PRO9739 Homo sapiens (Human) membrane [GO:0016020] HLALLAGLLVGVASK;SQPVRKPRYVR 2 6.8 0.95297 -0.73419 0 0 0 6.32785 0 0 0 0 0 0 0 0 Q96HA7 TONSL_HUMAN Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) TONSL IKBR NFKBIL2 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] histone binding [GO:0042393]; histone reader activity [GO:0140566] ELQLCSRRLCAEDR;FAELLDRPGAER;GVGSAQSR;LPEASQAHVR;RCSSGVK;RDLDLETR 6 4.3 0.97826 -2.1499 7.74322 7.18041 0 9.63496 0 0 0 0 0 0 0 11.8194 Q96HC4 PDLI5_HUMAN PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) PDLIM5 ENH L9 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell projection [GO:0042995]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actinin binding [GO:0042805]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080] ITGVSHR;LQGGKDFNMPLTISSAGVQWR;NLGSPQPPSPEFK 3 30.1 0.95144 -0.69301 0 0 0 0 0 0 9.3144 0 0 0 0 0 Q96HC4 PDLI5_HUMAN PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) PDLIM5 ENH L9 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell projection [GO:0042995]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actinin binding [GO:0042805]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080] ESEADNTKK;ESEADNTKKAK;FDSALEDLPK;FFAPECGRCQR;GPFLVALGK 5 6.6 0.96397 -1.1999 11.292 0 13.5233 4.97095 8.49137 0 0 0 0 0 0 0 Q96HE7 ERO1A_HUMAN ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) ERO1A ERO1L UNQ434/PRO865 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; chaperone cofactor-dependent protein refolding [GO:0051085]; collagen fibril organization [GO:0030199]; endoplasmic reticulum unfolded protein response [GO:0030968]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-ascorbic acid metabolic process [GO:0019852]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein maturation by protein folding [GO:0022417]; protein modification process [GO:0036211]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266]; skeletal muscle tissue development [GO:0007519]; transforming growth factor beta receptor signaling pathway [GO:0007179] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] EDFRLHFRNISR 1 2.6 0.87044 -0.095908 0 0 0 0 0 0 0 0 0 5.82296 0 0 Q96HE9 PRR11_HUMAN Proline-rich protein 11 PRR11 Homo sapiens (Human) regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] LTNVPACVLITPGDSK;SPGGTPLTNK;VDVERSPGGTPLTNK;VTNVLITPGKSQMDLRK 4 13.3 0.9673 -1.3073 9.07532 0 0 0 0 0 0 0 6.71232 0 6.76102 10.8409 Q96HH4 TM169_HUMAN Transmembrane protein 169 TMEM169 Homo sapiens (Human) membrane [GO:0016020] LGLEDCSPYSIVELLESDNISSTLSNK 1 9.1 0.71237 0.14489 0 0 0 0 0 0 8.61335 0 0 0 0 0 Q96HH6 TMM19_HUMAN Transmembrane protein 19 TMEM19 Homo sapiens (Human) membrane [GO:0016020] MTDLNDNICKR 1 3.3 0.73744 0.10894 0 0 0 9.25727 0 0 0 0 0 0 0 0 Q96HI0 SENP5_HUMAN Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) SENP5 FKSG45 Homo sapiens (Human) cell division [GO:0051301]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139] GFCYGCCQGPEHHR;KGIHLAFSEK;TWIKDEPLCAK;VTGDHQETRR 4 6 0.97363 -1.4151 0 0 10.9866 0 0 0 8.55021 0 6.43201 0 0 0 Q96HL8 SH3Y1_HUMAN SH3 domain-containing YSC84-like protein 1 SH3YL1 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661]; regulation of ruffle assembly [GO:1900027] ruffle membrane [GO:0032587] phosphatase binding [GO:0019902]; phosphatidylinositol binding [GO:0035091] AGFLVTARGGSGIVVARLPDGK;GGSGIVVARLPDGK 2 6.4 0.80634 0.0083165 15.5264 0 0 0 0 0 0 0 0 13.274 0 0 Q96HM7 PED1B_HUMAN PC-esterase domain-containing protein 1B (Protein FAM113B) PCED1B FAM113B Homo sapiens (Human) DLVLLLQKDRLLTPGQLR;HNFDVLDLHFHFRHAR;VYSDYLQTILK 3 10.4 0.95563 -0.87211 0 4.77563 0 0 0 0 0 0 0 0 0 9.91989 Q96HN2 SAHH3_HUMAN Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 KIAA0828 Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005] hydrolase activity [GO:0016787] ESILDGLKRTTDMMFGGK;FDNLYCCR;VRSQVDHVIWPDGK;YLGLNKNGPFKPNYYRY 4 9.3 0.86282 -0.083087 0 0 0 0 8.17163 0 0 0 0 0 0 0 Q96HP0 DOCK6_HUMAN Dedicator of cytokinesis protein 6 DOCK6 KIAA1395 Homo sapiens (Human) regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] guanyl-nucleotide exchange factor activity [GO:0005085] ELAFATEQDPPDAK;LAAVHGK;LVIRPPIISGQIVNLGR;LVRLVIRPPIISGQIVNLGR;NLLYVYPHSLNFSSR;SPFGNPENVRWRK;YQYLSAAYSPVTTDTQR;YQYLSAAYSPVTTDTQRERQK 8 4.4 0.96605 -1.1304 11.9864 0 6.72 8.28707 0 0 4.81003 0 0 0 0 9.52898 Q96HQ0 ZN419_HUMAN Zinc finger protein 419 ZNF419 ZNF419A Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFGQKYLLVQHQRLHAGK;FFRHNSSLFKHR;TYECSECGK;VPVLRSCK 4 9.2 0.97476 -3.1994 0 0 11.2941 0 0 0 0 0 10.5089 6.31428 0 0 Q96HR3 MED30_HUMAN Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) MED30 THRAP6 TRAP25 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] EIAEVNKK 1 4.5 0.84027 -0.043952 0 3.61847 0 0 0 0 0 3.93386 0 0 0 9.76708 Q96HU1 SGSM3_HUMAN Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) SGSM3 MAP RABGAPLP RUTBC3 Homo sapiens (Human) plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of cell cycle [GO:0051726]; regulation of Rab protein signal transduction [GO:0032483] cytosol [GO:0005829]; gap junction [GO:0005921] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] ALFEHGLK;FVEVLDERSK;GTLCPALK;QIEKDLLR;VLRHLIVQYLPRLDK 5 6.5 0.97582 -2.3473 0 0 0 9.20335 4.07493 0 11.268 0 0 0 0 9.92383 Q96HU8 DIRA2_HUMAN GTP-binding protein Di-Ras2 (EC 3.6.5.-) (Distinct subgroup of the Ras family member 2) DIRAS2 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] ELFQELLNLEKRR 1 6.5 0.8675 -0.091701 0 0 0 0 0 0 0 0 0 0 0 11.2105 Q96HY6 DDRGK_HUMAN DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) DDRGK1 C20orf116 UFBP1 Homo sapiens (Human) cartilage development [GO:0051216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of reticulophagy [GO:0140501]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K69-linked ufmylation [GO:1990592]; protein localization to endoplasmic reticulum [GO:0070972]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of protein stability [GO:0031647]; rescue of stalled ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin-like protein ligase binding [GO:0044389]; UFM1-modified protein reader activity [GO:0141185] DLGSRLQAQR;EAEWKKEEER;LEEEQKEEEERK;LEEKQAR 4 12.4 0.97606 -5.2219 0 0 0 0 0 0 10.5981 10.4967 10.416 0 0 0 Q96HY7 DHTK1_HUMAN "2-oxoadipate dehydrogenase complex component E1 (E1a) (OADC-E1) (OADH-E1) (EC 1.2.4.-) (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Alpha-KADH-E1) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)" DHTKD1 KIAA1630 Homo sapiens (Human) generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hematopoietic progenitor cell differentiation [GO:0002244] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoadipate dehydrogenase complex [GO:0160167] 2-oxoadipate dehydrogenase activity [GO:0160166]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] RFEELQKETFTTEER;TLVFCSGKHFYSLVK 2 3.3 0.95159 -0.70485 13.364 0 0 0 0 0 10.5476 0 0 0 0 0 Q96HZ4 HES6_HUMAN Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6) HES6 BHLHB41 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" AGRGSLPPTLGPRAR;LENAEVLELTVR 2 12.6 0.9572 -1.0271 0 0 0 0 0 0 0 0 0 0 0 12.0856 Q96HZ4 HES6_HUMAN Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6) HES6 BHLHB41 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" ASASLPATSSACTRCTR 1 15.2 0.91681 -0.4267 0 11.2677 11.3712 0 0 0 0 0 0 0 0 0 Q96I13 ABHD8_HUMAN Protein ABHD8 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 8) (Abhydrolase domain-containing protein 8) ABHD8 Homo sapiens (Human) extracellular exosome [GO:0070062] hydrolase activity [GO:0016787] LLVENLGRAPR 1 2.5 0.98012 -1.6526 0 0 0 0 0 0 0 0 0 8.55478 8.72663 0 Q96I15 SCLY_HUMAN Selenocysteine lyase (hSCL) (EC 4.4.1.16) SCLY SCL Homo sapiens (Human) amino acid metabolic process [GO:0006520]; selenocysteine catabolic process [GO:0016261] catalytic complex [GO:1902494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; selenocysteine lyase activity [GO:0009000]; transferase activity [GO:0016740]; vitamin B6 binding [GO:0070279] LEAEFGQK;LVTIMLANNETGIVMPVPEISQR 2 7 0.91196 -0.32362 0 0 0 0 7.89754 0 0 10.8354 10.4074 0 10.1397 0 Q96I23 PREY_HUMAN "Protein preY, mitochondrial (PIGY upstream reading frame protein)" PYURF NDUFAFQ PREY Homo sapiens (Human) protein stabilization [GO:0050821] endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739] APPSAVARRCLHASGSRPLADR 1 19.3 0.96318 -1.0849 0 0 9.15464 0 0 0 0 0 6.49261 0 0 0 Q96I24 FUBP3_HUMAN Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; intracellular mRNA localization [GO:0008298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] AELVQGQSAPVGMK;IQNDAGVR;TVITEEFKVPDK 3 5.9 0.022556 0.6196 0 11.805 0 0 0 0 0 0 0 0 0 0 Q96I25 SPF45_HUMAN Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) RBM17 SPF45 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]" nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] QREERQR;TSKRGGK 2 3.5 0.82604 -0.019284 0 0 0 0 0 0 0 0 8.04674 0 0 0 Q96I27 ZN625_HUMAN Zinc finger protein 625 ZNF625 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFVSFNSVRYHER;DHQHGEILTQVPDDMLKK 2 10.1 0.71266 0.15235 0 0 7.62051 0 0 0 0 0 0 9.28506 0 0 Q96I34 PP16A_HUMAN Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) PPP1R16A MYPT3 Homo sapiens (Human) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020] LLELKHKHDALLR;RAQQVKMWAQAEK;VGGSPVRHLYSK;VVRRVSLTQR 4 9.1 0.97527 -3.5605 0 0 0 0 10.7731 0 0 7.57259 11.4429 0 0 0 Q96I36 COX14_HUMAN Cytochrome c oxidase assembly protein COX14 COX14 C12orf62 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] AQRQAAEEQK 1 17.5 0.88648 -0.18257 0 0 0 0 0 0 0 0 10.5988 0 0 0 Q96I45 TM141_HUMAN Transmembrane protein 141 TMEM141 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] MVNLGLSR 1 7.4 0.91325 -0.39033 0 0 10.8715 0 0 0 0 0 0 0 0 0 Q96I59 SYNM_HUMAN "Asparaginyl-tRNA synthetase (AsnRS) (NARS2) (EC 6.1.1.22) (Asparagine--tRNA ligase, mitochondrial)" NARS2 Homo sapiens (Human) asparaginyl-tRNA aminoacylation [GO:0006421] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] DVIPFPRFPHSCLL;HPLEYLR;TEHEKYLVK 3 6.3 0.96482 -1.2344 7.897 0 0 7.12681 0 9.70325 0 0 0 0 0 0 Q96I76 GPTC3_HUMAN G patch domain-containing protein 3 GPATCH3 GPATC3 Homo sapiens (Human) negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] EEEEESHSDEDDDR;GGGFLCFHYR;GLAQAQRLIRMYSGR;GLGYHGEKLQPFGQLK;TTEQLFEEEIELKWEK 5 13.5 0.96875 -1.3298 9.06124 0 8.70155 0 6.00621 10.1045 0 0 0 0 0 8.99285 Q96I99 SUCB2_HUMAN "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)" SUCLG2 Homo sapiens (Human) succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (GDP-forming) [GO:0045244] ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] DPNVVGQLAK;EQIDIFEGIKDSQAQR;LEGTFMEKKGSYMHIK;MAENLGFVGPLK 4 12.3 0.68169 0.1649 0 0 12.0255 0 0 0 0 0 0 8.70577 10.7473 0 Q96IC2 REXO5_HUMAN RNA exonuclease 5 (EC 3.1.-.-) (Exonuclease NEF-sp) REXO5 44M2.3 Homo sapiens (Human) rRNA 3'-end processing [GO:0031125] extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634] exonuclease activity [GO:0004527]; RNA binding [GO:0003723] DIQCPDRLGHDATEDARTILELAR;VILGKDIQCPDR 2 3.7 0.95216 -0.75527 0 0 0 0 0 0 0 6.07767 0 0 10.0912 0 Q96ID5 IGS21_HUMAN Immunoglobulin superfamily member 21 (IgSF21) IGSF21 Homo sapiens (Human) "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse maturation [GO:0060074]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" adherens junction [GO:0005912]; external side of plasma membrane [GO:0009897]; inhibitory synapse [GO:0060077]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] EFPRWVHSAEPTYFLR;EIVWYRVTDGGTIKQK;LPEVRISDNGPYECHVGIYDR 3 11.3 0.90475 -0.27061 0 10.0736 0 0 10.6934 0 8.26875 7.58931 0 0 9.70938 0 Q96IF1 AJUBA_HUMAN LIM domain-containing protein ajuba AJUBA JUB Homo sapiens (Human) "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; glycerophospholipid biosynthetic process [GO:0046474]; lamellipodium assembly [GO:0030032]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; wound healing, spreading of epidermal cells [GO:0035313]" adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] actin filament binding [GO:0051015]; alpha-catenin binding [GO:0045294]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; transcription corepressor activity [GO:0003714] DYHFECYHCEDCR 1 2.4 0.70859 0.15854 0 0 0 6.27532 0 0 0 0 0 6.26277 0 0 Q96IG2 FXL20_HUMAN F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) "behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]" cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685] DIEGRVVENISK 1 2.8 0.98043 -1.5994 0 0 0 0 0 9.66001 0 0 0 0 0 0 Q96II8 LRCH3_HUMAN DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) LRCH3 Homo sapiens (Human) septin cytoskeleton organization [GO:0032185] cytoplasm [GO:0005737]; cytosol [GO:0005829] ASQSPQK 1 0.9 0.6011 0.17736 0 0 11.7259 0 0 0 0 0 0 0 3.71984 0 Q96IJ6 GMPPA_HUMAN Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) GMPPA Homo sapiens (Human) cognition [GO:0050890]; GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose metabolic process [GO:0019673]; motor behavior [GO:0061744]; muscle organ morphogenesis [GO:0048644]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of nucleobase-containing compound metabolic process [GO:0045934]; negative regulation of phosphate metabolic process [GO:0045936]; negative regulation of small molecule metabolic process [GO:0062014]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; protein glycosylation [GO:0006486]; skeletal muscle organ development [GO:0060538]; telencephalon development [GO:0021537] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GDP-mannose pyrophosphorylase complex [GO:0120508] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; transferase activity [GO:0016740] GVTVGEGVR 1 2.1 0.93023 -0.48003 0 0 0 0 0 0 0 10.1731 0 0 0 0 Q96IK5 GMCL1_HUMAN Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29) GMCL1 BTBD13 GCL SPATA29 Homo sapiens (Human) germ cell development [GO:0007281]; spermatogenesis [GO:0007283] nuclear matrix [GO:0016363]; nucleus [GO:0005634] identical protein binding [GO:0042802] LRLASFDSSGK;MGSLSSR 2 3.5 0.90929 -0.3158 0 0 0 0 0 0 0 0 7.65421 0 0 0 Q96IL0 COA8_HUMAN "Cytochrome c oxidase assembly factor 8 (COA8) (Apoptogenic protein 1, mitochondrial) (APOP-1)" COA8 APOP1 APOPT1 C14orf153 Homo sapiens (Human) intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of cytochrome-c oxidase activity [GO:1904960]; protein stabilization [GO:0050821]; response to reactive oxygen species [GO:0000302] matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrion [GO:0005739] RDTAPSGVSR 1 4.9 0.91859 -0.43599 0 0 8.93127 0 0 0 0 0 0 0 0 0 Q96IQ9 ZN414_HUMAN Zinc finger protein 414 ZNF414 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] VSPLLSEGELPVFSQL 1 4.1 0.93708 -0.54259 0 0 0 0 0 0 0 0 0 0 11.4602 0 Q96IR3 YV007_HUMAN Putative uncharacterized protein MGC15705 Homo sapiens (Human) MTRNVVR 1 17.1 0.90582 -0.27179 0 0 0 7.59373 9.52454 8.58797 0 0 0 0 0 0 Q96IT1 ZN496_HUMAN Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) ZNF496 ZKSCAN17 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFQRHDHLARHR;SFTQNYDLLRHERLHMK;SLPASHRSSTEAGGEVQTSK 3 8.3 0.97497 -3.1632 0 0 0 0 0 10.5128 0 0 12.231 0 0 0 Q96IU2 ZBED3_HUMAN Zinc finger BED domain-containing protein 3 (Axin-interacting protein) ZBED3 Homo sapiens (Human) actin filament organization [GO:0007015]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DDPEGDR 1 3 0.91436 -0.3362 4.31947 0 0 0 0 0 0 0 0 0 0 0 Q96IV0 NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 PNG1 Homo sapiens (Human) glycoprotein catabolic process [GO:0006516]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224] AVGFEAR;CGEWANCFTLCCR;EALLRDTINGLNK;FECGSVGLK;ISGSVAWR;LSYVIAFSK;VETDWHMVYLARK;YSCKHEEVIARR 8 12.8 0.97665 -2.2811 2.8737 0 0 9.66445 0 8.10187 0 11.115 11.0927 0 0 0 Q96IW7 SC22A_HUMAN Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2) SEC22A SEC22L2 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] SNAP receptor activity [GO:0005484] DGLPLSASTDYEQSTGMQECR 1 6.8 0.78114 0.021467 5.39215 0 0 0 0 0 0 0 0 0 0 0 Q96IY4 CBPB2_HUMAN Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI) CPB2 Homo sapiens (Human) blood coagulation [GO:0007596]; cellular response to glucose stimulus [GO:0071333]; fibrinolysis [GO:0042730]; liver regeneration [GO:0097421]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of plasminogen activation [GO:0010757]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to xenobiotic stimulus [GO:0009410] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] HPDMLTKIHIGSSFEK;YIKPTCR 2 5.4 0.98086 -1.7928 0 0 0 0 0 0 0 0 0 0 0 11.9234 Q96IZ5 RBM41_HUMAN RNA-binding protein 41 (RNA-binding motif protein 41) RBM41 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626] ILCLPQRFAKSK;LSEEEIR 2 4.6 0.94057 -0.58682 0 0 0 0 0 0 0 8.77939 3.40912 0 0 0 Q96IZ5 RBM41_HUMAN RNA-binding protein 41 (RNA-binding motif protein 41) RBM41 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626] ILCLPQRFAKSK;KTSADKYMTSMK 2 7.7 0.95992 -1.0507 0 0 0 0 0 0 0 0 0 0 10.3991 0 Q96IZ7 RSRC1_HUMAN Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) RSRC1 SRRP53 BM-011 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]; nucleocytoplasmic transport [GO:0006913]; response to antibiotic [GO:0046677]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] VQRSRSK 1 2.1 0.81145 -0.014979 10.2467 0 0 0 0 0 0 0 0 0 0 0 Q96J02 ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) ITCH Homo sapiens (Human) "apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of defense response to virus [GO:0050687]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of T cell anergy [GO:0002669]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein branched polyubiquitination [GO:0141198]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; regulation of cell growth [GO:0001558]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of necroptotic process [GO:0060544]; regulation of protein deubiquitination [GO:0090085]; symbiont entry into host cell [GO:0046718]; T cell anergy [GO:0002870]; ubiquitin-dependent protein catabolic process [GO:0006511]" cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] arrestin family protein binding [GO:1990763]; CXCR chemokine receptor binding [GO:0045236]; ligase activity [GO:0016874]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] LLFAIEETEGFGQE;MVAEWRLSR 2 2.5 0.93632 -0.52682 0 0 8.75726 0 0 0 0 0 0 0 0 0 Q96J42 TXD15_HUMAN Thioredoxin domain-containing protein 15 TXNDC15 C5orf14 UNQ335/PRO534 Homo sapiens (Human) cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] ciliary membrane [GO:0060170]; cilium [GO:0005929] FSASLAPHFNSLPR;MVPAAGR 2 5.8 0.91592 -0.36592 0 0 0 0 0 0 0 0 6.65464 0 0 0 Q96J65 MRP9_HUMAN ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9) ABCC12 MRP9 Homo sapiens (Human) transmembrane transport [GO:0055085] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626] MVGEGPYLISDLDQR 1 1.1 0.89313 -0.22164 0 0 0 0 7.77742 0 8.97487 0 0 0 0 0 Q96J66 MRP8_HUMAN ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8) ABCC11 MRP8 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; organic anion transport [GO:0015711]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216] LWEEEVSRR;MYTWEKPFAKIIEDLR 2 1.8 0.96441 -1.2228 3.63842 0 0 0 0 0 0 0 3.63192 0 0 0 Q96J77 TPD55_HUMAN Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3) TPD52L3 Homo sapiens (Human) cytoplasm [GO:0005737] SFEGLMGTIK 1 7.1 0.89706 -0.2342 0 0 0 0 0 0 0 0 0 0 8.45278 0 Q96J77 TPD55_HUMAN Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3) TPD52L3 Homo sapiens (Human) cytoplasm [GO:0005737] YTLNQGRN 1 5.9 0.92924 -0.48385 0 0 0 0 0 0 10.662 0 0 0 0 0 Q96J84 KIRR1_HUMAN Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) KIRREL1 KIRREL NEPH1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; glomerular filtration [GO:0003094]; positive regulation of actin filament polymerization [GO:0030838]; renal protein absorption [GO:0097017] cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; dendritic shaft [GO:0043198]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022] VVFTCQATANPEILGYR 1 2.2 0.78524 0.02486 0 0 0 0 0 8.00338 0 0 0 0 0 0 Q96J87 CELF6_HUMAN CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6) CELF6 BRUNOL6 Homo sapiens (Human) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] IYELTVLKDR;LFVGQIPR;LTGLHKGCAFLTYCAR 3 7.1 0.95506 -0.93929 0 0 0 11.305 11.2718 10.0201 0 0 0 0 0 0 Q96J92 WNK4_HUMAN Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) WNK4 PRKWNK4 Homo sapiens (Human) aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; renal sodium ion transport [GO:0003096]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; ion channel inhibitor activity [GO:0008200]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIIEGCIR;GSFPTSR;KEIEDLYSRLGK;SPPPSSK 4 2.7 0.96141 -1.0655 0 0 0 0 0 0 8.0662 0 9.49889 0 0 7.85275 Q96J92 WNK4_HUMAN Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) WNK4 PRKWNK4 Homo sapiens (Human) aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; renal sodium ion transport [GO:0003096]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; ion channel inhibitor activity [GO:0008200]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIIEGCIR;LGAAPNP 2 2.3 0.6091 0.17545 9.12815 8.31836 0 3.30871 10.7363 10.8176 9.03947 0 9.15416 0 0 0 Q96J94 PIWL1_HUMAN Piwi-like protein 1 (EC 3.1.26.-) PIWIL1 HIWI Homo sapiens (Human) meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; primary piRNA processing [GO:0140990]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] IALQMNCKMGGELWR;KAIMIEVDDR;LTPEQRQR;RDFHDLGVNTRQNLDHVK;SIAGFVASINEGMTR;VTPAMGMQMRK 6 8.8 0.97563 -3.3408 8.99078 0 0 9.85573 0 0 0 10.142 0 0 10.1059 10.7226 Q96JA1 LRIG1_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) LRIG1 LIG1 Homo sapiens (Human) hair cycle process [GO:0022405]; innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] TEGGPQANGHIESNGVCPR;VVCSDCNTEVDCYSR;YQCVITNHFGSTYSHKARLTVNVLPSFTK 3 5.8 0.13728 0.35415 0 0 0 4.32963 0 0 0 8.80423 0 0 7.20848 0 Q96JA3 PKHA8_HUMAN Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86) PLEKHA8 FAPP2 Homo sapiens (Human) ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273] GVFALALRAAPSYEDFVAALTVK 1 4.4 0.88824 -0.18881 0 0 0 0 0 8.97255 0 0 0 0 0 0 Q96JA4 M4A14_HUMAN Membrane-spanning 4-domains subfamily A member 14 (Testis development protein NYD-SP21) MS4A14 MS4A13 MS4A16 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] GWQSPKQKSLDQQIK;LLQDQAASLQVFPSHSALK;SLDQQIK;TLFIGILLILLIISIAELSISVTIASFR 4 8.7 0.88709 -0.19382 0 11.6352 0 0 0 0 5.59434 10.7296 0 10.8444 0 0 Q96JB1 DYH8_HUMAN Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) DNAH8 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] ATRLSLDTMK;AVLLTGEQGTAKTVMVKAYLK;AVSVQEDLVQVQPK;DAMTHLIKISRIIR;EKENDLQVTSLNHK;ELISIFEQIYEVK;FDAAMNEKMDLLNDADTCRK;FEVEVTK;FQKLNIPCLGLEINHTIER;FRNIYQGVKK;GLCIFFVRCR;HVEEAVR;ILWVRQLYRR;IMDCVLLLFQKKIDPVTMDPEK;IMQVTNQK;LDVPEQAK;LLNCFAR;LLVNFDPK;LSQDLAVK;LVLLLSSSVNSLR;SSLSDLK;TVAMMVPDR;YLYTLEK 23 5.9 0.97865 -9.5253 11.0831 0 12.4784 9.72627 7.81948 0 10.9414 8.01853 8.62728 9.40695 10.6042 0 Q96JB2 COG3_HUMAN Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) COG3 SEC34 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] EQIAPFHTEFTIK;QYLFVSNK;TRDAAFKILNPMTVPR 3 4.5 0.93664 -0.54565 0 0 5.21607 0 6.77189 9.82428 0 0 0 8.28697 0 0 Q96JB3 HIC2_HUMAN Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) HIC2 HRG22 KIAA1020 ZBTB30 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AGSTGMGRPPR;VPNGILASGAGPSGPYGEPPYPCK 2 5.7 0.89367 -0.22588 0 0 0 7.10873 10.5006 0 0 0 0 8.46524 0 0 Q96JB6 LOXL4_HUMAN Lysyl oxidase homolog 4 (EC 1.4.3.13) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C) LOXL4 LOXC Homo sapiens (Human) collagen fibril organization [GO:0030199] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; receptor complex [GO:0043235] copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] QVCDQGWTMNNSR;YGQGEGPIWLDNVR 2 3.6 0.78502 0.027469 0 0 0 0 0 0 0 4.96966 0 10.5345 0 0 Q96JB8 MPP4_HUMAN MAGUK p55 subfamily member 4 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein) (Discs large homolog 6) MPP4 ALS2CR5 DLG6 Homo sapiens (Human) protein localization to synapse [GO:0035418] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] FSCLSLPR;GADPPDK;VITDYYVDMK 3 4.2 0.96703 -1.2989 0 14.214 5.10039 0 0 0 0 0 0 0 0 0 Q96JC1 VPS39_HUMAN Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) VPS39 KIAA0770 TLP VAM6 Homo sapiens (Human) autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; regulation of SNARE complex assembly [GO:0035542] AP-3 adaptor complex [GO:0030123]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] GLHEKALQVLVDQSKK;MAEEYCHKHYDRNK;NLYAFNLFCQKR;YSELIILYEKK 4 6 0.93714 -0.53973 0 0 0 0 0 6.1426 0 0 0 6.8334 0 9.44415 Q96JC4 ZN479_HUMAN Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19) ZNF479 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGERPYTCEECGK;IIHTGEKPYKCE;SYKCKECGK;TRYTGNK;VIPRTYGKCGHEK 5 10.7 0.97494 -2.363 0 0 0 0 0 0 9.31039 9.67886 0 6.27486 0 9.63283 Q96JC9 EAF1_HUMAN ELL-associated factor 1 EAF1 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368] Cajal body [GO:0015030]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] transcription elongation factor activity [GO:0003711] ASFHTIR;LGESFEK 2 5.2 0.90876 -0.30968 0 0 0 0 0 0 0 0 0 9.18408 0 0 Q96JD6 AKCL2_HUMAN "1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (LoopADR) (Testis aldo-keto reductase) (htAKR) (Testis-specific protein) (hTSP)" AKR1E2 AKR1CL2 AKRDC1 Homo sapiens (Human) cytosol [GO:0005829] "1,5-anhydro-D-fructose reductase activity [GO:0050571]; aldose reductase (NADPH) activity [GO:0004032]; oxidoreductase activity [GO:0016491]" GDIPAVGLSSWKASPGK;IAKEHGKSPAQILIR 2 10 0.97271 -2.6091 0 8.49494 0 0 0 0 9.50924 0 0 0 0 0 Q96JD6 AKCL2_HUMAN "1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (LoopADR) (Testis aldo-keto reductase) (htAKR) (Testis-specific protein) (hTSP)" AKR1E2 AKR1CL2 AKRDC1 Homo sapiens (Human) cytosol [GO:0005829] "1,5-anhydro-D-fructose reductase activity [GO:0050571]; aldose reductase (NADPH) activity [GO:0004032]; oxidoreductase activity [GO:0016491]" FKPLTNQILIR;GDIPAVGLSSWKASPGK 2 11.2 0.89793 -0.23529 0 0 0 0 0 0 0 0 0 0 0 9.73369 Q96JE7 SC16B_HUMAN Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) SEC16B KIAA1928 LZTR2 RGPR SEC16S Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031] cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] EDEKESSDEADK;EEYAYGSYYYHGHPQWLQEERVPR;KEALEWAMK;SETLGSR 4 4.9 0.97876 -1.9186 0 0 0 6.87012 8.87538 0 0 0 5.98242 0 0 0 Q96JE7 SC16B_HUMAN Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) SEC16B KIAA1928 LZTR2 RGPR SEC16S Homo sapiens (Human) endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031] cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] ALGLEACLDQR;EDEKESSDEADK 2 4.3 0.93395 -0.4984 11.7242 0 0 0 0 0 0 0 0 0 0 0 Q96JE9 MAP6_HUMAN Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP) MAP6 KIAA1878 Homo sapiens (Human) cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite morphogenesis [GO:0048813]; lysosome localization [GO:0032418]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of axonogenesis [GO:0050772]; regulation of microtubule cytoskeleton organization [GO:0070507] axon [GO:0030424]; cis-Golgi network [GO:0005801]; dendrite [GO:0030425]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle membrane [GO:0030658] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017] DQGPRIPEPVK;KAGPAWIVR;QAVSGQAAK 3 3.6 0.97597 -1.4522 0 0 0 0 0 0 12.7055 12.9281 10.0243 0 0 0 Q96JF0 SIAT2_HUMAN "Beta-galactoside alpha-2,6-sialyltransferase 2 (Alpha 2,6-ST 2) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2) (ST6Gal II) (ST6GalII) (hST6Gal II) (Sialyltransferase 2)" ST6GAL2 KIAA1877 SIAT2 Homo sapiens (Human) oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; sialylation [GO:0097503] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]" WAQSQDGFEHK 1 2.1 0.89783 -0.23971 7.20643 0 0 0 0 0 0 0 0 0 0 0 Q96JF6 ZN594_HUMAN Zinc finger protein 594 (Zinc finger protein HZF18) ZNF594 KIAA1871 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AYWCNQCGR;GKPYLCNKCGK;GSSDLIK 3 4.5 0.98059 -1.6266 0 0 0 0 0 0 0 3.0951 8.71273 0 0 0 Q96JG6 VPS50_HUMAN Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) VPS50 CCDC132 KIAA1861 Homo sapiens (Human) endocytic recycling [GO:0032456]; protein transport [GO:0015031] EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037] SNARE binding [GO:0000149] ARQKLLAAIDDIDRPK;KRQLLIGLLK;LTDIRPIPDK;QLLIGLLKSLRTIK;TIVEGYANVK 5 5.4 0.084906 0.39111 7.20056 0 3.92077 0 6.1943 0 0 8.69498 0 10.5105 3.80529 3.94326 Q96JG8 MAGD4_HUMAN Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen) MAGED4 KIAA1859 MAGED4A MAGEE1; MAGED4B Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] EVAATRPKTTK 1 1.5 0.92173 -0.44283 0 0 0 0 0 0 0 9.40109 9.38519 0 0 0 Q96JG9 ZN469_HUMAN Zinc finger protein 469 ZNF469 KIAA1858 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of extracellular matrix organization [GO:1903053] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] EVELTQGPR;EVELTQGPREDEPQKPR;GASARGFWGPR;KKPASTENGQWK;LLPCEQR;LVTELESQLQR;SLETGAAAREGGPK;SPGPPGLPSPPAAPR;VELGTGTEPPSQRR;VTCPSTGLGLGR 10 2.9 0.97573 -5.0649 0 0 0 0 0 5.90667 11.3695 0 0 11.3898 9.44595 6.10043 Q96JH7 VCIP1_HUMAN Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) VCPIP1 KIAA1850 VCIP135 Homo sapiens (Human) DNA damage response [GO:0006974]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; regulation of protein localization to chromatin [GO:1905634] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] EFNIPPYLQCIRYGFPPK 1 1.5 0.91586 -0.43283 0 0 0 0 0 0 0 0 9.05704 0 0 0 Q96JH8 RADIL_HUMAN Ras-associating and dilute domain-containing protein RADIL KIAA1849 Homo sapiens (Human) neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] microtubule [GO:0005874]; protein-containing complex [GO:0032991] GTPase binding [GO:0051020] AVDLIRHGGKK;LCGAALGARGAASPTQAALPRR;SDVETAK;SDVETAKK 4 3.8 0.96549 -1.2464 12.9047 0 9.3522 0 0 0 0 0 0 0 9.71857 0 Q96JI7 SPTCS_HUMAN Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) autophagosome organization [GO:1905037]; axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cholesterol efflux [GO:0033344]; corticospinal tract morphogenesis [GO:0021957]; localization within membrane [GO:0051668]; lysosome organization [GO:0007040]; memory [GO:0007613]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; neuromuscular junction development [GO:0007528]; phagosome-lysosome fusion involved in apoptotic cell clearance [GO:0090389]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; regulation of store-operated calcium entry [GO:2001256]; skeletal muscle fiber development [GO:0048741]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]; walking behavior [GO:0090659] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; synapse [GO:0045202] protein kinase binding [GO:0019901] CRNEDAQYSFIR;EKNYFSEKEK;HLLLTLAGHWLAQEDVVPLDKLEELEKQIWLCR;ILASQQPDR;ILEDLPIQGPKGVDEDDPVNSAYNMK;LAFENLPSVPTSK;LLQLFVER;LSPENCPFLEK;LSPENCPFLEKK;QAQHCQRLTK;QARIDFWK;RCRPGDSEK;RLSSESSSQWALVVQFCRLHNMK;TQYELGKLLQLFVEREHLFSDGPDVK 14 7.8 0.97698 -5.6584 16.1369 15.9129 15.913 0 14.1974 13.8829 0 14.8326 11.1592 14.0004 12.7351 15.0745 Q96JJ3 ELMO2_HUMAN Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) ELMO2 CED12A KIAA1834 Homo sapiens (Human) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell chemotaxis [GO:0060326]; cell motility [GO:0048870]; phagocytosis [GO:0006909] cytosol [GO:0005829]; membrane [GO:0016020] receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124] IAFDAESDPSNAPGSGTEK;QERFWYCRLALNHK;SIILNHVIR;TEMAHQLYVLQVLTFNLLEER 4 8.8 0.95538 -0.934 6.25803 0 0 9.53019 9.87113 0 11.7444 11.5836 0 0 0 0 Q96JJ6 JPH4_HUMAN Junctophilin-4 (JP-4) (Junctophilin-like 1 protein) JPH4 JPHL1 KIAA1831 Homo sapiens (Human) calcium ion transport into cytosol [GO:0060402]; learning [GO:0007612]; neuromuscular process controlling balance [GO:0050885]; regulation of cytokine production [GO:0001817]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic plasticity [GO:0048167] dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] AVSAARQRQEIAAAR;QSVPYHQAALLR 2 4.3 0.97913 -1.5337 0 0 11.352 0 0 0 0 11.5861 0 0 0 0 Q96JJ7 TMX3_HUMAN Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) TMX3 KIAA1830 TXNDC10 Homo sapiens (Human) cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] SIIQEVAR 1 1.8 0.89264 -0.22473 0 0 0 0 0 0 0 0 0 0 9.98257 0 Q96JK2 DCAF5_HUMAN DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) DCAF5 BCRG2 KIAA1824 WDR22 Homo sapiens (Human) negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] AGLGGSMRSVVGFLSQR;DCCGSEMACETPNAGTR;LSALRRYQDK;RRLPPVLYDIHSR;VLLWHMEQAIHSR;WLRYSYISYSNNK 6 8.8 0.97621 -2.2635 0 0 4.10811 0 0 9.6271 9.75937 0 12.8191 0 0 0 Q96JK4 HIPL1_HUMAN HHIP-like protein 1 HHIPL1 HHIP2 KIAA1822 UNQ9245/PRO34761 Homo sapiens (Human) extracellular region [GO:0005576]; membrane [GO:0016020] IDVDRKER;RAEFGQGGSLPILLDDVR;RLYVYYSVGIR;TVPGLCQDYCLDMWHK;VLRIDVDR 5 7.2 0.97672 -2.2811 0 0 9.74618 0 8.76371 0 12.013 0 11.4098 0 0 9.30012 Q96JK9 MAML3_HUMAN Mastermind-like protein 3 (Mam-3) MAML3 KIAA1816 Homo sapiens (Human) Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] QMAAQQQQR;TLEQRAKK 2 1.5 0.98034 -2.0366 0 0 0 0 0 0 6.63535 7.47671 0 0 8.33851 0 Q96JL9 ZN333_HUMAN Zinc finger protein 333 ZNF333 KIAA1806 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NLASVADQLCKPNALSYLEER;SLYRDVMLENYR;TFTRNFNLILHQR 3 6.9 0.91681 -0.36235 12.4034 0 0 0 0 0 0 0 0 0 0 12.9679 Q96JM2 ZN462_HUMAN Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) ZNF462 KIAA1803 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AQPEGKNNLFK;DLRCPLCLYHTK;EDKYSCQYCSFVSAFR;EEEMNSKAEDR;EEEMNSKAEDRELMR;EIPNTTVSNFR;FSPMSYPQMKPK;HPSIKVTAEDFVHDVEQSADISQNDVEETSRIFK;LKTHILKAHAGEHAYK;SLLENAEAKKE;VVGYKCKFCVEVHPTLR;YLQGVVFRCDK 12 6.6 0.9757 -4.2965 11.4979 8.76202 4.61506 0 8.49574 0 12.3111 10.5681 11.1395 0 8.02674 7.2116 Q96JM3 CHAP1_HUMAN Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) CHAMP1 C13orf8 CAMP CHAMP KIAA1802 ZNF828 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; protein localization to kinetochore [GO:0034501]; protein localization to microtubule [GO:0035372]; sister chromatid biorientation [GO:0031134] condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] metal ion binding [GO:0046872] GKYYCKICCCR;LSPDQRK;MIFYQKSAK;NQLNKETDPVK;SSRGGSPDLWK;YYCKICCCR 6 6 0.97969 -1.8245 0 10.4068 0 0 0 5.79374 0 0 7.10392 9.27193 0 6.77057 Q96JM4 LRIQ1_HUMAN Leucine-rich repeat- and IQ domain-containing protein 1 LRRIQ1 KIAA1801 Homo sapiens (Human) regulation of signal transduction [GO:0009966] AEIEAELDK;EKAAILIQAVWK;FKQHEEYIR;ITRIGYSFFLEEK;KISEEWGFKDISTAQQMLK;LENIQKQEQDK;LKESISSQTILADFKMEEK;NLVDENSK;NQAHRHSAGSSSK;QERKYENTDNK;RCGLTSLHSLSNCKK;TNEEQKIIKDNQQK 12 8.9 0.97473 -3.7372 12.593 0 0 10.6765 10.3796 10.8845 13.7718 0 12.2886 10.6771 13.9647 11.2706 Q96JM7 LMBL3_HUMAN Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) L3MBTL3 KIAA1798 MBT1 Homo sapiens (Human) chromatin organization [GO:0006325]; erythrocyte maturation [GO:0043249]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription initiation-coupled chromatin remodeling [GO:0160217]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylation-dependent protein binding [GO:0140034]; zinc ion binding [GO:0008270] AVAVPAK;GIGHFKRAR;HIKDKDQK;QGLPPKGK 4 4.1 0.97503 -4.0512 0 16.1558 15.1886 0 0 0 0 0 0 0 0 9.85741 Q96JN0 LCOR_HUMAN Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) LCOR C10orf12 KIAA1795 MLR2 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; nuclear estrogen receptor binding [GO:0030331]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; ubiquitin-specific protease binding [GO:1990381] DVSHSSPVDLK;EASWAKPHYEFNLSRMKFR;KLRAILPK;NSSTQDPSQPNSTK 4 12 0.95448 -0.82205 0 0 0 0 0 0 0 0 9.11145 4.1127 0 0 Q96JN0 LCOR_HUMAN Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) LCOR C10orf12 KIAA1795 MLR2 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; nuclear estrogen receptor binding [GO:0030331]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; ubiquitin-specific protease binding [GO:1990381] AANGHSR;EGQPTPRARNK;ELRGEIFPSR;LKEIWKSK;NSSTQDPSQPNSTK;QDLEANEQDARPKQENHLHSLGR;SLVIVKK 7 5.1 0.97656 -2.1877 4.32041 0 7.77742 0 6.7879 9.23518 10.9331 10.6345 10.889 4.33578 11.6235 0 Q96JN2 CC136_HUMAN Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein) CCDC136 KIAA1793 NAG6 Homo sapiens (Human) acrosome assembly [GO:0001675]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] acrosomal membrane [GO:0002080] LDGLAKEEEK;LLEERKR;QLREKRPSVVK;SLEVVLYYKASQR;STLVENQSEK;SYGSTSSSDTCQK 6 5.5 0.97535 -3.3686 0 0 14.1141 0 12.8729 7.64032 0 8.66409 10.8401 9.48234 8.32715 0 Q96JN8 NEUL4_HUMAN Neuralized-like protein 4 NEURL4 KIAA1787 Homo sapiens (Human) mitochondrial DNA repair [GO:0043504]; spermatogenesis [GO:0007283] centriole [GO:0005814]; mitochondrion [GO:0005739] ubiquitin protein ligase activity [GO:0061630] LVSLSACGRTAR;SLCYCESCR;SLCYCESCRKLR;TVAGELR;VGVERTVAGELR 5 2.3 0.96679 -1.2874 5.12458 0 10.9065 0 0 0 11.6602 0 0 0 8.30629 7.1534 Q96JP0 FEM1C_HUMAN Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GADVNRKSVK;TAVFNAARDGK;VIVNHRIYYK 3 5 0.97468 -3.7537 12.3331 0 0 0 0 0 0 0 0 0 0 0 Q96JP2 MY15B_HUMAN Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) MYO15B KIAA1783 MYO15BP Homo sapiens (Human) brush border [GO:0005903]; cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DTGPAKDASDNR;EKQGPLLDLFGQK;ELLSWVPVPQPPR;GGRGRPTLASR;GHGRGSK;GQADRAKPAAEPATAGGQGTPGGRR;LCQQEKLRDEIYCQVIK;LLSVARALGLLRWLR;LSLETRLQQEGDPGLRGSLR;SLNGDTSGGDGGSSCPDSETR;TVKYGGR 11 5.2 0.97693 -4.8672 9.2412 10.7229 11.2052 0 9.21162 0 0 0 0 12.399 9.50393 8.64064 Q96JP5 ZFP91_HUMAN E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) ZFP91 ZNF757 FKSG11 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] SPRLLCIEK;YQHLLKK 2 2.8 0.97961 -1.8417 0 0 0 0 0 0 0 0 0 12.1182 0 0 Q96JP9 CDHR1_HUMAN Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21) CDHR1 KIAA1775 PCDH21 PRCAD Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845] photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FDSLYYVAR;IDITDAETLSR;THYITVVAK;TMVLGTPVK 4 4.4 0.9784 -2.1003 0 0 10.6618 0 12.3473 0 0 0 0 0 0 0 Q96JQ0 PCD16_HUMAN Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) DCHS1 CDH19 CDH25 FIB1 KIAA1773 PCDH16 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mitral valve formation [GO:0003192]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659] apical part of cell [GO:0045177]; catenin complex [GO:0016342]; membrane [GO:0016020] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AEDRDAGANASILYR;DHGAPGR;EQRAEHVLTVVASDHGSPPR;TAAALDR;VLDREQRDR;VSYRLASGGDGHFR 6 2.2 0.97842 -1.9413 7.7286 0 0 11.1487 11.1128 7.39515 0 0 0 10.3751 7.108 0 Q96JQ2 CLMN_HUMAN Calmin (Calponin-like transmembrane domain protein) CLMN KIAA1188 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; nuclear migration [GO:0007097] cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640] actin filament binding [GO:0051015] FNSDLIDFASTSQAFNK;TSHSDSSIYLRRHTHR 2 3.3 0.82559 -0.020835 10.7967 5.9287 0 0 0 0 0 0 0 0 0 11.2675 Q96JS3 PGBD1_HUMAN PiggyBac transposable element-derived protein 1 (Cerebral protein 4) PGBD1 hucep-4 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] membrane [GO:0016020] DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] CVFGVLLLSGFMRHPRR 1 2.1 0.42926 0.19575 0 0 0 0 8.84772 0 0 0 0 0 0 0 Q96JT2 S45A3_HUMAN Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) SLC45A3 PCANAP6 PRST Homo sapiens (Human) hexose transmembrane transport [GO:0008645]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; regulation of oligodendrocyte differentiation [GO:0048713]; sucrose transport [GO:0015770] membrane [GO:0016020]; plasma membrane [GO:0005886] sucrose:proton symporter activity [GO:0008506]; sugar transmembrane transporter activity [GO:0051119] LHQLCCRMPR;MVQRLWVSRLLR;SDLAKYSA 3 5.4 0.94094 -0.6084 0 0 0 0 6.07895 0 0 0 7.30314 0 8.54871 0 Q96JX3 SRAC1_HUMAN Protein SERAC1 (Serine active site-containing protein 1) SERAC1 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; intracellular cholesterol transport [GO:0032367]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] DIRNIIK;DSPALKTLQDDFLEFAK;IGTSTSPPKSGTHWRDIR;SEESDLRFFLLPPPLPSLK;TTRLEAVR 5 10.1 0.97718 -2.2284 8.9012 7.70155 10.8294 9.1574 0 0 0 8.55984 0 0 0 0 Q96JY0 MAEL_HUMAN Protein maelstrom homolog MAEL Homo sapiens (Human) cell morphogenesis [GO:0000902]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; genomic imprinting [GO:0071514]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reproductive process [GO:2000242]; negative regulation of transcription by RNA polymerase II [GO:0000122]; piRNA processing [GO:0034587]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of organ growth [GO:0046620]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] autosome [GO:0030849]; chromatin [GO:0000785]; chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; piP-body [GO:0071547]; XY body [GO:0001741] sequence-specific DNA binding [GO:0043565] KASRNAYYFFVQEK;QKPVFTPLR;SLLDVAMWDYSSNTR 3 8.8 0.97876 -2.0578 0 0 0 0 0 0 0 0 5.74768 0 0 0 Q96JY6 PDLI2_HUMAN PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) PDLIM2 PP6345 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; protein catabolic process [GO:0030163] adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625] TGERQPGER 1 1.5 0.9032 -0.26324 0 0 8.77416 0 0 0 0 0 0 0 8.32603 0 Q96K12 FACR2_HUMAN Fatty acyl-CoA reductase 2 (FAR2) (EC 1.2.1.84) (Male sterility domain-containing protein 1) FAR2 MLSTD1 Homo sapiens (Human) long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491] LFRTSPDLKVIYILVRPK 1 3.5 0.76524 0.063676 0 0 0 0 0 3.44679 0 0 0 0 0 0 Q96K17 BT3L4_HUMAN Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) BTF3L4 Homo sapiens (Human) KMMMFQIL;LAVNNIAGIEESWTVKHQNQK 2 37.2 0.95507 -0.87882 0 0 0 0 0 9.70805 0 0 0 0 0 0 Q96K19 RN170_HUMAN E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) RNF170 Homo sapiens (Human) adult walking behavior [GO:0007628]; gene expression [GO:0010467]; innate immune response [GO:0045087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; response to activity [GO:0014823]; response to temperature stimulus [GO:0009266]; toll-like receptor 3 signaling pathway [GO:0034138] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LCFTLLDCVSILWFSG 1 8 0.90947 -0.31741 0 0 0 0 0 8.578 0 0 0 0 0 0 Q96K21 ANCHR_HUMAN Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) ZFYVE19 ANCHR MPFYVE Homo sapiens (Human) abscission [GO:0009838]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] CAGCDGDLFCARCFR;CFREGHDAFELK;LPDSDDDEDEETAIQR;LRQENKPK;QDQMIAERLAR 5 12.5 0.97316 -2.4893 0 0 0 5.92609 0 0 4.14763 0 0 0 10.124 0 Q96K30 RITA1_HUMAN RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) RITA1 C12orf52 RITA PSEC0043 Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] tubulin binding [GO:0015631] LSMGGLHSSRPLK 1 4.8 0.89679 -0.23752 0 0 0 0 0 0 0 0 11.8792 0 0 0 Q96K37 S35E1_HUMAN Solute carrier family 35 member E1 SLC35E1 PSEC0038 Homo sapiens (Human) transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297] AAAAVGAGHGAGGPGAASSSGGAR 1 5.9 0.80725 0.0084121 0 0 0 0 0 0 8.00647 0 0 0 0 0 Q96K49 TM87B_HUMAN Transmembrane protein 87B TMEM87B Homo sapiens (Human) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] CQSDWMER;LLVIIVSLGYGIVKPR;RTLARLLVIIVSLGYGIVKPR;TLARLLVIIVSLGYGIVKPR;VALCLLCWTPAAVR 5 7.7 0.94189 -0.62048 0 0 0 0 2.96971 0 7.37565 5.72996 0 10.809 8.96009 8.60807 Q96K58 ZN668_HUMAN Zinc finger protein 668 ZNF668 Homo sapiens (Human) DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFLSASDLR;DVWVPRETPFTK;MFSDPSSFR;RYKCLSCTK 4 6.1 0.97242 -2.7854 0 0 0 8.67529 0 0 0 0 0 10.7536 8.93846 10.3924 Q96K62 ZBT45_HUMAN Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499) ZBTB45 ZNF499 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TPGAEPPTYECSHCR 1 2.9 0.78321 0.023422 0 0 0 0 0 0 0 0 0 9.42114 0 0 Q96K75 ZN514_HUMAN Zinc finger protein 514 ZNF514 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVMLENFR;SFHFQSELR 2 4.2 0.84698 -0.066059 0 0 0 0 0 0 0 0 0 7.02978 0 0 Q96K76 UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) USP47 Homo sapiens (Human) base-excision repair [GO:0006284]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; WD40-repeat domain binding [GO:0071987] AGGDSGNVDDDCER;DPARNAK;ITLAAFK;IVLERCYNDLR;LKDPARNAK;SLLDANFEPGK;SLLDANFEPGKKNFLHLTDK;SVEAILEESTEKLK 8 5.5 0.97275 -2.5974 12.9763 7.94075 11.6235 0 9.29749 4.80519 0 7.72479 4.58244 0 8.78418 0 Q96K78 AGRG7_HUMAN Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128) ADGRG7 GPR128 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ASCRAWNLR;IVIRIQRGK;LTAENITSATR;SLPSVTRPRLR 4 5 0.97355 -2.5511 0 0 0 0 0 0 2.54406 13.0556 0 0 0 0 Q96K80 ZC3HA_HUMAN Zinc finger CCCH domain-containing protein 10 ZC3H10 ZC3HDC10 Homo sapiens (Human) negative regulation of miRNA processing [GO:1903799]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] GVECRLLEEENAMLRK 1 3.7 0.48109 0.19047 0 0 0 0 0 2.71609 0 0 0 0 0 0 Q96K83 ZN521_HUMAN Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) ZNF521 EHZF LIP3 Homo sapiens (Human) neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IYDCTQCPQK;TRCSSCNVK;VGGLKTRCSSCNVK 3 1.8 0.94129 -0.61453 0 0 0 0 0 0 0 5.84679 6.53667 0 0 9.16594 Q96KA5 CLP1L_HUMAN Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (CRR9p) (Cleft lip and palate transmembrane protein 1-like protein) (CLPTM1-like protein) CLPTM1L CRR9 Homo sapiens (Human) apoptotic process [GO:0006915] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] phospholipid scramblase activity [GO:0017128] SMIGMSTKAVLWR;TEEYDTQAMK 2 4.3 0.98027 -1.8036 0 14.7979 0 0 0 0 0 6.24133 0 0 0 0 Q96KB5 TOPK_HUMAN Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) PBK TOPK Homo sapiens (Human) cellular response to UV [GO:0034644]; mitotic cell cycle [GO:0000278]; negative regulation of inflammatory response [GO:0050728]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of stress-activated MAPK cascade [GO:0032873]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; stress-activated MAPK cascade [GO:0051403] nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] GLKYLHQEK;GLKYLHQEKK;LGFGTGVNVYLMKR;VALNMARGLK 4 9.6 0.98026 -1.8032 0 10.3494 0 0 0 0 0 0 10.3074 0 10.3038 0 Q96KC2 ARL5B_HUMAN ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8) ARL5B ARL8 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192] trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LAITKEELYRMLAHEDLR 1 10.1 0.50662 0.18788 0 0 0 0 0 0 0 11.0548 0 0 0 0 Q96KC8 DNJC1_HUMAN DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) DNAJC1 HTJ1 Homo sapiens (Human) negative regulation of proteolysis [GO:0045861]; protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; protein-folding chaperone binding [GO:0051087] TPLLWLLLLLLAAVAPAR;YKLLVELVQKK 2 5.2 0.37085 0.22535 0 0 0 0 0 0 7.64645 4.89956 0 0 0 0 Q96KE9 BTBD6_HUMAN BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) neurogenesis [GO:0022008] cytosol [GO:0005829] LFEEPELTQR 1 1.9 0.92858 -0.46192 0 0 0 9.79821 0 0 0 0 0 0 0 0 Q96KG7 MEG10_HUMAN Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) apoptotic cell clearance [GO:0043277]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; muscle cell proliferation [GO:0033002]; myoblast development [GO:0048627]; myoblast migration [GO:0051451]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of myoblast proliferation [GO:2000288]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] cell projection [GO:0042995]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886] complement component C1q complex binding [GO:0001849]; Notch binding [GO:0005112]; scavenger receptor activity [GO:0005044] CQDECPVGTYGVLCAETCQCVNGGK;DCALICQCQNGADCDHISGQCTCR;DPPVLIPK;DSPYAEINNSTSANR;GWRCEDRCEQGTYGNDCHQR;QEDSGGSSSNSSSSSE;SYMGKSLK;TAYRHGEK 8 10.9 0.97593 -2.2582 0 9.14698 0 0 0 9.08313 0 0 0 0 9.5194 6.56497 Q96KG9 SCYL1_HUMAN N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019 Homo sapiens (Human) "inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; spinal cord motor neuron differentiation [GO:0021522]" centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA binding [GO:0003677]; protein tyrosine kinase activity [GO:0004713] FVETNLFLEEIQIKEPAEKQK;IIPVVVK;VEAGGLK;VLTSAFSRATRDPFAPSR;WSADMWR 5 7.4 0.98047 -1.6681 0 0 9.75173 8.20989 0 0 0 0 0 3.82304 8.10774 0 Q96KJ9 COX42_HUMAN "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)" COX4I2 COX4L2 Homo sapiens (Human) "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129] KGGGGRR;LQFNETFAEMNRR;VNPVQGLASRWDYEK 3 20.5 0.86761 -0.09167 0 0 7.42987 10.1475 9.98371 0 0 10.7052 0 0 0 0 Q96KK3 KCNS1_HUMAN Delayed-rectifier potassium channel regulatory subunit KCNS1 (Delayed-rectifier K(+) channel alpha subunit 1) (Delayed-rectifier potassium channel subunit Kv9.1) (hKv9.1) (Potassium voltage-gated channel modifier subfamily S member 1) KCNS1 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] LAASGCILGGILVVALPITIIFNK 1 4.6 0.80679 0.0084121 0 0 0 0 0 0 0 0 0 4.6143 0 0 Q96KK4 O10C1_HUMAN Olfactory receptor 10C1 (Hs6M1-17) (Olfactory receptor 10C2) OR10C1 OR10C2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPSVAGRR 1 2.6 0.92417 -0.44806 0 0 14.4493 0 0 0 0 0 0 0 12.4632 0 Q96KM6 Z512B_HUMAN Zinc finger protein 512B ZNF512B KIAA1196 Homo sapiens (Human) negative regulation of miRNA transcription [GO:1902894] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" AAGPASPPEEDPERTKHR;AENQALR;APRATGR;KEVRLPMLHDPPK;TLVGLKKHMEVCQK 5 6.6 0.97675 -2.2394 4.39211 7.50962 9.33626 0 7.34359 8.4232 9.78629 0 0 0 0 8.05241 Q96KN2 CNDP1_HUMAN Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase) CNDP1 CN1 CPGL2 UNQ1915/PRO4380 Homo sapiens (Human) proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246] cytosol [GO:0005829]; extracellular region [GO:0005576] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] HLEDVFSKRNSSNK 1 2.8 0.95883 -1.0088 0 0 6.44241 0 0 0 12.4691 0 0 0 0 0 Q96KN7 RPGR1_HUMAN X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1) RPGRIP1 Homo sapiens (Human) neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601] axoneme [GO:0005930]; ciliary rootlet [GO:0035253]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206] thromboxane A2 receptor binding [GO:0031870] EKEHQVVSYSR;QVNELRAELK;RAQPRVQVGHR 3 2.5 0.97453 -2.3823 0 0 0 0 0 5.78002 0 0 8.06889 0 0 0 Q96KN7 RPGR1_HUMAN X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1) RPGRIP1 Homo sapiens (Human) neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601] axoneme [GO:0005930]; ciliary rootlet [GO:0035253]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206] thromboxane A2 receptor binding [GO:0031870] EKEHQVVSYSR;MLKLDNK 2 2.9 0.98056 -1.6098 0 0 0 0 0 0 0 0 0 12.383 0 0 Q96KN8 PLAT5_HUMAN "Phospholipase A and acyltransferase 5 (Ca(2+)-independent N-acyltransferase) (iNAT) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (H-rev107-like protein 5) (HRAS-like suppressor 5) (HRSL5)" PLAAT5 HRASLS5 HRLP5 Homo sapiens (Human) N-acylphosphatidylethanolamine metabolic process [GO:0070292] cytoplasm [GO:0005737]; cytosol [GO:0005829] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] SEGCWSSYFSCSG;SIQQGEK 2 7.9 0.90736 -0.30528 0 8.05224 0 0 0 0 0 0 4.461 0 0 0 Q96KN9 CXD4_HUMAN Gap junction delta-4 protein (Connexin-40.1) (Cx40.1) GJD4 CX40.1 Homo sapiens (Human) cell-cell signaling [GO:0007267]; regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014717] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] EPASGQRRCPRPFGER 1 4.3 0.95758 -1.0169 0 0 0 0 0 0 0 0 0 0 10.716 9.12306 Q96KP1 EXOC2_HUMAN Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 SEC5 SEC5L1 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] ITQVSMASLK;IVCRVGQAK;KYYAEVETRIEALR;LTKLVLSQLPNFWKLWISYVNGSLFSETAEK;RGSSFQSGR;TPHRVAFVEK;VIEAVSEELSR 7 10.2 0.95818 -1.0143 12.1017 11.7384 0 9.71684 0 10.0129 0 6.51734 10.9541 11.0491 8.36851 0 Q96KP4 CNDP2_HUMAN Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase) CNDP2 CN2 CPGL HEL-S-13 PEPA Homo sapiens (Human) proteolysis [GO:0006508] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] AALTTLFK;DILMHRWR;LNRYNYIEGTK;LYDDIDFDIEEFAK;TVFGVEPDLTR 5 10.9 0.93691 -0.52434 0 0 0 0 0 0 11.5626 0 0 8.82864 8.46434 0 Q96KP6 TNIP3_HUMAN TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein) TNIP3 ABIN3 LIND Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 4 signaling pathway [GO:0034142] cytosol [GO:0005829] polyubiquitin modification-dependent protein binding [GO:0031593] QQVQIYEEDFKK;TEMEVLK 2 5.8 0.91047 -0.29463 0 0 0 0 0 0 10.5588 10.6361 0 6.98527 0 0 Q96KQ4 ASPP1_HUMAN Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) PPP1R13B ASPP1 KIAA0771 Homo sapiens (Human) intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] p53 binding [GO:0002039] LQKLKER;NMEVAMMDK;RKDESETEWWWAR 3 2.7 0.9162 -0.43301 0 0 8.33602 9.67599 0 9.75522 0 0 0 0 6.67624 0 Q96KQ7 EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) EHMT2 BAT8 C6orf30 G9A KMT1C NG36 Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; fertilization [GO:0009566]; long-term memory [GO:0007616]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; oocyte development [GO:0048599]; organ growth [GO:0035265]; peptidyl-lysine dimethylation [GO:0018027]; phenotypic switching [GO:0036166]; regulation of DNA replication [GO:0006275]; regulation of protein modification process [GO:0031399]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] IDRISERAGHK;LGVGNRAIR;TEKIICR;VVQSGIKVR 4 3 0.97577 -4.3358 0 0 0 0 0 0 0 13.0001 0 11.543 0 0 Q96KR1 ZFR_HUMAN Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) ZFR Homo sapiens (Human) chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] FHCKLCECSFNDPNAK;GVLRVGVLAKGLLLR;ISCAGPQTYKEHLEGQKHK;LLAFRQIHK 4 5.5 0.97504 -1.445 0 6.29945 0 4.19125 4.15421 0 0 4.77331 0 0 4.8885 0 Q96KR4 LMLN_HUMAN Leishmanolysin-like peptidase (EC 3.4.24.-) (Invadolysin) LMLN Homo sapiens (Human) cell adhesion [GO:0007155]; cell division [GO:0051301]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lipid droplet [GO:0005811]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233] LDWGRGMGCDFVRK;SAFVMEK;SCKFWIDQQR;SNPLQLTCRQDQR 4 6.4 0.97344 -2.9038 0 0 9.59798 9.89807 9.45177 0 10.3699 9.74636 9.54427 0 0 0 Q96KR6 F210B_HUMAN "Protein FAM210B, mitochondrial" FAM210B C20orf108 PSEC0265 Homo sapiens (Human) cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ISITLVSVPLIVRYFRK 1 8.9 0.86434 -0.087737 0 0 0 0 0 0 0 0 0 0 3.71853 0 Q96KR7 PHAR3_HUMAN Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin) PHACTR3 C20orf101 SCAPIN1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036] nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] ADKPWTR;LSKRLSQRPAVEELER;LSQRPAVEELER 3 4.1 0.78487 0.029831 0 0 0 0 0 0 0 0 0 11.4156 9.49304 0 Q96KS0 EGLN2_HUMAN Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) EGLN2 EIT6 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; estrogen receptor signaling pathway [GO:0030520]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of protein catabolic process [GO:0045732]; regulation of cell growth [GO:0001558]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; oxygen sensor activity [GO:0019826]; peptidyl-proline 4-dioxygenase activity [GO:0031545] LALDYIVPCMR;YAITVWYFDAKER 2 5.9 0.93794 -0.57551 12.3534 0 0 0 0 0 12.3433 0 0 0 0 0 Q96KS9 F167A_HUMAN Protein FAM167A FAM167A C8orf13 Homo sapiens (Human) ALTEKLR;EAGQHPPSAR 2 7.9 0.90969 -0.29506 0 0 0 0 0 0 0 7.69342 0 0 0 10.6028 Q96KV6 BT2A3_HUMAN Putative butyrophilin subfamily 2 member A3 BTN2A3P BTN2A3 Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] WFQSQFSPAVFVYK 1 2.4 0.79946 0.014684 0 0 0 6.57289 0 0 0 0 0 4.05632 0 0 Q96KV7 WDR90_HUMAN WD repeat-containing protein 90 WDR90 C16orf15 C16orf16 C16orf17 C16orf18 C16orf19 KIAA1924 Homo sapiens (Human) cilium assembly [GO:0060271] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] LLFTAAR;LLPTRTPGGPHPQK 2 1.2 0.95219 -0.75656 13.1146 0 0 0 0 0 0 0 0 7.79429 0 0 Q96KV7 WDR90_HUMAN WD repeat-containing protein 90 WDR90 C16orf15 C16orf16 C16orf17 C16orf18 C16orf19 KIAA1924 Homo sapiens (Human) cilium assembly [GO:0060271] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] ATWHPPSLPSALGMGR 1 5.9 0.7848 0.029314 0 0 0 0 0 0 0 0 0 0 8.20614 0 Q96KX1 CD036_HUMAN Uncharacterized protein C4orf36 C4orf36 Homo sapiens (Human) LEREYEVK;TILRGSCYNVQEPWDIALLAK 2 24.8 0.95338 -0.777 0 0 0 0 0 0 0 10.3305 0 0 5.36261 0 Q96L12 CALR3_HUMAN Calreticulin-3 (Calreticulin-2) (Calsperin) CALR3 CRT2 Homo sapiens (Human) cell differentiation [GO:0030154]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; spermatogenesis [GO:0007283] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] HEQKMDCGGGYIK;INRHEHYFNQFHRR 2 7 0.96496 -1.2202 0 0 0 0 0 0 0 0 0 6.81083 6.86567 11.0765 Q96L15 NAR5_HUMAN Ecto-ADP-ribosyltransferase 5 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 5) (ARTC5) (Mono(ADP-ribosyl)transferase 5) (NAD(P)(+)--arginine ADP-ribosyltransferase 5) ART5 UNQ575/PRO1137 Homo sapiens (Human) extracellular region [GO:0005576] NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779] GSGGCSR 1 2.4 0.71069 0.15906 0 0 0 7.16692 0 0 0 0 0 0 8.37495 0 Q96L21 RL10L_HUMAN Ribosomal protein uL16-like (60S ribosomal protein L10-like) (Large ribosomal subunit protein uL16-like) RPL10L Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; ribosomal large subunit assembly [GO:0000027]; spermatogenesis [GO:0007283]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] YVPSHGPLDKWRVLHS 1 7.5 0.95885 -1.01 0 0 0 0 0 0 11.5967 0 0 0 0 0 Q96L34 MARK4_HUMAN MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) MARK4 KIAA1860 MARKL1 Homo sapiens (Human) cell division [GO:0051301]; cilium organization [GO:0044782]; intracellular signal transduction [GO:0035556]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; positive regulation of cell cycle [GO:0045787]; positive regulation of cilium assembly [GO:0045724]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein localization to centrosome [GO:1904781]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; gamma-tubulin complex [GO:0000930]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; neuron projection [GO:0043005] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cytoskeletal anchor activity [GO:0008093]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; gamma-tubulin binding [GO:0043015]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin binding [GO:0043130] GLNHPNIVKLFEVIETEK;KTEEGGDRGAPGLALAR;SLGARCR;VTLDPSK 4 7.1 0.97781 -2.1601 6.87492 9.70926 6.87529 0 0 0 11.0783 10.4516 8.84546 0 0 0 Q96L50 LLR1_HUMAN Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) LRR1 PPIL5 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleus [GO:0005634] AVLSLCQQTSR;LQAPLTLLESSARTILHNR 2 7.2 0.82529 -0.019131 0 0 0 0 0 0 7.18527 0 12.4098 0 0 0 Q96L50 LLR1_HUMAN Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) LRR1 PPIL5 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleus [GO:0005634] AVLSLCQQTSR;KNLCLWKILSELFHSR 2 18.5 0.84244 -0.051912 0 0 0 0 0 4.698 0 11.5131 0 0 0 0 Q96L58 B3GT6_HUMAN "Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)" B3GALT6 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein O-linked glycosylation [GO:0006493]; proteoglycan biosynthetic process [GO:0030166] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020] galactosylxylosylprotein 3-beta-galactosyltransferase activity [GO:0047220]; UDP-galactosyltransferase activity [GO:0035250] LYWGFFSGRGR;QSLEDMLEK 2 6.1 0.97951 -1.8546 0 0 0 0 0 0 0 0 0 0 0 10.3938 Q96L73 NSD1_HUMAN "Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)" NSD1 ARA267 KMT3B Homo sapiens (Human) methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H4K20 methyltransferase activity [GO:0042799]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] AGKKPHYREIVWVK;CCSSDTK;EDECFSCGDAGQLVSCK;GLSFENGK;GVDGTYK;GVDGTYKKALQEAAAR;HKVPQKILSK;NQPIATEEK 8 3 0.9789 -1.9604 0 0 5.68252 0 6.52754 11.0294 6.66917 0 5.43486 0 11.8737 0 Q96L91 EP400_HUMAN E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) EP400 CAGH32 KIAA1498 KIAA1818 TNRC12 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein antigen binding [GO:1990405] AGLWSQR;ASRLFQPVQYGQKPEGR;IGLDWLAKLYRK;KDLVLIDSLFIMDQFKAAER;LDQIYLVNER;LQRICNHPGLVEPR;LVRTVVRHHEEK;NLNGILADEAGLGK;TLQEREAR;VPAVRLK;VTQPFILR 11 4.1 0.9762 -5.0387 0 11.4068 10.6947 8.42945 10.0712 9.23165 0 0 0 3.74298 11.3727 0 Q96L93 KI16B_HUMAN Kinesin-like protein KIF16B (Sorting nexin-23) KIF16B C20orf23 KIAA1590 SNX23 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; spindle [GO:0005819] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]" AGGDEDGEELEK;EILESREK;INAYIEEEVQR;ISIPRYVLCGQGK;KRQEEETFLR;LEYEIQQLK;LQATFEFTANIARQEEKVR;LQQNEARVQELTKEWTNK;RQEEETFLR;SLGANPDDLK;VGLTLSK 11 8.9 0.97271 -2.7728 9.77898 9.93904 11.5791 5.14987 0 0 11.4125 13.7308 0 9.78555 0 8.16656 Q96L96 ALPK3_HUMAN Alpha-protein kinase 3 (EC 2.7.11.1) (Muscle alpha-protein kinase) ALPK3 KIAA1330 MAK Homo sapiens (Human) cardiac muscle cell development [GO:0055013]; heart development [GO:0007507] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGGLDTEVALDEGKQETLAKPRK;AVPGEVDTLRKLSPDR;RLTGLLDR;SPTQGRKASMLEVPR 4 3.6 0.98123 -1.7738 0 0 10.4501 12.4147 0 0 0 0 0 9.42599 0 8.61268 Q96LA5 FCRL2_HUMAN Fc receptor-like protein 2 (FcR-like protein 2) (FcRL2) (Fc receptor homolog 2) (FcRH2) (IFGP family protein 4) (Immunoglobulin receptor translocation-associated protein 4) (SH2 domain-containing phosphatase anchor protein 1) (CD antigen CD307b) FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; immune response [GO:0006955] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020] protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; transmembrane signaling receptor activity [GO:0004888] ISGESSATNEPR;TQRSLSAELEIPAVKESDAGK 2 6.5 0.96302 -1.0858 0 0 0 0 0 9.49901 0 0 0 0 0 4.56438 Q96LA6 FCRL1_HUMAN Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a) FCRL1 FCRH1 IFGP1 IRTA5 Homo sapiens (Human) B cell activation [GO:0042113] cell surface [GO:0009986]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026] SEAVTLNFTGR 1 3 0.86496 -0.090117 0 0 0 8.23232 0 0 0 0 0 0 0 0 Q96LA9 MRGX4_HUMAN Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6) MRGPRX4 MRGX4 SNSR5 SNSR6 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] MDPTVPVFGTKLTPINGR;QNRQNLKLVLQR 2 9.3 0.87361 -0.11497 0 0 0 0 0 0 0 10.1887 0 0 0 10.0784 Q96LB1 MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 MRGPRX2 MRGX2 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; mast cell activation [GO:0045576]; mast cell degranulation [GO:0043303]; positive regulation of cytokinesis [GO:0032467]; sensory perception of pain [GO:0019233]; sleep [GO:0030431] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; mast cell secretagogue receptor activity [GO:1990595]; neuropeptide binding [GO:0042923] LQQPILKLALQR 1 3.6 0.83651 -0.035001 0 0 0 0 0 0 0 0 4.05563 0 0 0 Q96LB3 IFT74_HUMAN Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) IFT74 CCDC2 CMG1 Homo sapiens (Human) cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; intraciliary transport involved in cilium assembly [GO:0035735]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of transcription by RNA polymerase II [GO:0045944] acrosomal vesicle [GO:0001669]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634] beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682] DDNQEIASMERQLTDTK;SIGSPMEEREK;SVEEEIEQEK;WQHLEQNNFAMK 4 8.3 0.98007 -1.8308 7.77709 7.62834 0 0 7.69084 0 0 0 9.67299 11.6631 9.57067 9.07639 Q96LB4 VATG3_HUMAN V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3) ATP6V1G3 ATP6G3 Homo sapiens (Human) synaptic vesicle lumen acidification [GO:0097401] "cytosol [GO:0005829]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" MQRDKEFR 1 6.8 0.97687 -1.4911 0 0 0 0 0 0 8.88533 0 0 0 0 0 Q96LC9 BMF_HUMAN Bcl-2-modifying factor BMF Homo sapiens (Human) anoikis [GO:0043276]; cellular response to UV [GO:0034644]; negative regulation of autophagy [GO:0010507]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] EQERGRP;REQERGRP 2 6.2 0.91754 -0.35733 0 0 0 9.40759 9.89306 0 0 0 0 0 0 0 Q96LD1 SGCZ_HUMAN Zeta-sarcoglycan (Zeta-SG) (ZSG1) SGCZ Homo sapiens (Human) cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047]; membrane organization [GO:0061024]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] VLFSADEDEITIGAEK 1 5.4 0.77894 0.035148 0 0 0 0 0 6.58052 0 0 0 0 0 0 Q96LD4 TRI47_HUMAN E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47) TRIM47 GOA RNF100 Homo sapiens (Human) protein ubiquitination [GO:0016567]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynapse [GO:0098794] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ALAFYAVRDGK;LEESLCPR;NAHSCCLQWNGR 3 4.9 0.95784 -1.016 0 0 0 0 0 0 0 0 0 9.83284 0 10.1731 Q96LD8 SENP8_HUMAN "Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)" SENP8 DEN1 NEDP1 PRSC2 FKSG8 Homo sapiens (Human) post-translational protein modification [GO:0043687]; protein deneddylation [GO:0000338]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829] cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784] KGDKLAFVEEK;LEAFLGR 2 8.5 0.93295 -0.51396 0 0 0 0 0 0 11.0021 0 0 0 0 0 Q96LI5 CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B) CNOT6L CCR4B Homo sapiens (Human) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535] IMSEQER;ITHGFQLK 2 2.7 0.96559 -1.1459 0 0 0 0 0 0 0 0 0 7.59268 0 0 Q96LI9 CX058_HUMAN Uncharacterized protein CXorf58 CXorf58 Homo sapiens (Human) EKNTSEVTEPK;SLQKVRR 2 5.4 0.95678 -1.0245 0 0 0 0 0 0 0 0 0 0 0 9.03425 Q96LJ8 UBX10_HUMAN UBX domain-containing protein 10 (UBX domain-containing protein 3) UBXN10 UBXD3 Homo sapiens (Human) cilium assembly [GO:0060271]; ERAD pathway [GO:0036503] cilium [GO:0005929]; endoplasmic reticulum [GO:0005783] ubiquitin binding [GO:0043130] KNLEEEAVETVAKK 1 5 0.86478 -0.086821 0 0 0 0 0 0 0 0 0 0 9.25941 0 Q96LK8 SPT32_HUMAN Spermatogenesis-associated protein 32 (Testis-expressed protein 34) SPATA32 C17orf46 TEX34 Homo sapiens (Human) spermatogenesis [GO:0007283] perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779] EKENPLLVK;LIQASEHSLQR 2 5.2 0.9525 -0.76012 6.57083 6.03793 0 0 0 0 0 0 0 5.96885 0 0 Q96LL3 FIMP_HUMAN Fertilization-influencing membrane protein FIMP C16orf92 Homo sapiens (Human) fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] plasma membrane [GO:0005886] ATASALGTESPR;FLDRPDFFDYPDSDQAR;RATASALGTESPR 3 22.7 0.95428 -0.95936 0 11.6244 0 0 0 0 0 0 0 4.87066 0 0 Q96LL4 CH048_HUMAN Uncharacterized protein C8orf48 C8orf48 Homo sapiens (Human) IYFKNMR;LTEKSHIR;SHIRYSGFER 3 6.6 0.97983 -1.8224 0 8.6319 0 0 0 0 6.53573 0 0 7.93387 0 0 Q96LP2 FA81B_HUMAN Protein FAM81B FAM81B Homo sapiens (Human) nucleus [GO:0005634] HLQGVGDLRGR;IVELQEV;LEKSENKMEEK 3 6.4 0.95908 -1.0353 0 0 0 0 9.92736 0 0 0 0 7.32715 0 9.51175 Q96LP6 CL042_HUMAN Uncharacterized protein C12orf42 C12orf42 Homo sapiens (Human) HIPCYER;SPCYIPIVSSATLWDR 2 6.4 0.95409 -0.88887 0 0 0 0 0 7.91654 0 0 0 0 0 0 Q96LQ0 PPR36_HUMAN Protein phosphatase 1 regulatory subunit 36 PPP1R36 C14orf50 Homo sapiens (Human) phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864] EKAQNVFEKK;HHMCCGK;LAAKDDK 3 5.7 0.9793 -1.8941 0 0 0 0 0 0 0 0 6.27137 5.98461 10.8496 0 Q96LR2 LURA1_HUMAN Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) LURAP1 C1orf190 LRAP35A LRP35A Homo sapiens (Human) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] TPEGLLR;TPEGLLRGLR;VIAGGER 3 7.1 0.97702 -2.2126 0 0 0 0 0 0 0 6.71781 0 10.6985 0 11.2817 Q96LR4 TAFA4_HUMAN Chemokine-like protein TAFA-4 TAFA4 FAM19A4 Homo sapiens (Human) macrophage chemotaxis [GO:0048246]; phagocytosis [GO:0006909]; regulation of membrane potential [GO:0042391]; regulation of sensory perception of pain [GO:0051930]; regulation of signaling receptor activity [GO:0010469]; superoxide anion generation [GO:0042554] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synaptic vesicle membrane [GO:0030672] receptor ligand activity [GO:0048018] LMSASSQHLRGHAGHHQIK 1 13.6 0.91843 -0.43647 0 0 0 0 0 0 0 0 0 0 0 10.1944 Q96LR7 CMIP5_HUMAN Ciliary microtubule inner protein 5 CIMIP5 C2orf50 Homo sapiens (Human) cilium [GO:0005929] LPPTRPPASVSPAAR 1 9.3 0.89362 -0.21922 0 8.97585 0 0 0 0 0 0 0 0 0 0 Q96LS8 CB048_HUMAN Putative uncharacterized protein C2orf48 C2orf48 Homo sapiens (Human) SDQPYVLK 1 5 0.93578 -0.52742 0 0 0 0 0 0 0 0 0 10.0828 0 0 Q96LT7 CI072_HUMAN Guanine nucleotide exchange factor C9orf72 C9orf72 DENND9 DENNL72 Homo sapiens (Human) autophagy [GO:0006914]; axon extension [GO:0048675]; endocytosis [GO:0006897]; late endosome to lysosome transport [GO:1902774]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of macroautophagy [GO:0016239]; regulation of actin filament organization [GO:0110053]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of TORC1 signaling [GO:1903432]; stress granule assembly [GO:0034063] autophagosome [GO:0005776]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; main axon [GO:0044304]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] LTHIIRK;STFLAQFLLVLHRKALTLIK 2 5.6 0.94194 -0.6161 0 0 0 0 0 9.20921 0 9.14608 0 0 0 0 Q96LT9 RNPC3_HUMAN RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) RNPC3 KIAA1839 RBM40 RNP SNRNP65 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689] pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626] HLPAELTAEEK 1 2.1 0.93781 -0.57549 0 0 0 0 9.35711 0 0 0 0 0 0 0 Q96LU7 MRFL_HUMAN Myelin regulatory factor-like protein MYRFL C12orf15 C12orf28 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; protein autoprocessing [GO:0016540] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] AVHKKNNK 1 0.9 0.87013 -0.095167 0 0 10.8735 0 0 0 0 0 0 0 0 0 Q96LW1 Z354B_HUMAN Zinc finger protein 354B ZNF354B Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]" YKCSTCEKAFIHNSSLR 1 2.8 0.96413 -1.094 0 0 0 0 0 0 0 0 10.5933 0 0 0 Q96LW4 PRIPO_HUMAN DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.102) (EC 2.7.7.7) (Coiled-coil domain-containing protein 111) PRIMPOL CCDC111 Homo sapiens (Human) error-prone translesion synthesis [GO:0042276]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; R-loop processing [GO:0062176]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] DNA-directed RNA polymerase complex [GO:0000428]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; replication fork [GO:0005657] chromatin binding [GO:0003682]; DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270] RWNYFFPEELLVYDICKYR 1 3.4 0.86222 -0.082939 0 0 0 0 7.72492 7.78836 0 0 0 0 0 0 Q96LW7 CAR19_HUMAN Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) CARD19 C9orf89 Homo sapiens (Human) negative regulation of canonical NF-kappaB signal transduction [GO:0043124] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] CARD domain binding [GO:0050700] MTDQTYCDR 1 4.9 0.87866 -0.14032 0 6.37448 0 0 0 0 0 0 0 0 0 0 Q96LX7 CCD17_HUMAN Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) ANPGTLAAEIRALR;VAEMEAQSR 2 3.7 0.95984 -1.0515 11.3352 0 0 0 0 10.139 0 0 0 0 0 0 Q96LZ2 MAGBA_HUMAN Melanoma-associated antigen B10 (MAGE-B10 antigen) MAGEB10 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] HIYVLVNK;VSATAGARSK 2 5.2 0.97955 -1.8434 0 0 0 0 0 0 0 0 0 0 12.329 0 Q96LZ7 RMD2_HUMAN Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1) RMDN2 FAM82A FAM82A1 BLOCK18 UNQ9371/PRO34163 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] EKFRDEIEFMWR;INYGHLFK;IPSSTVQEALHNFLK 3 8.5 0.95275 -0.67722 0 13.0794 10.1288 7.89391 9.98257 9.68354 4.65547 0 9.60728 0 6.96613 0 Q96M02 CJ090_HUMAN (E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS) C10orf90 FATS Homo sapiens (Human) protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of centriole replication [GO:0046599] actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630] GPEAELPPK;IYDNLPEVK;KQFTIPHPLSDNLFKPKER;VFSGSSK 4 6.3 0.9761 -1.4837 0 0 0 0 0 0 0 9.73581 0 10.4435 0 9.83002 Q96M20 CNBD2_HUMAN Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) spermatogenesis [GO:0007283] cytosol [GO:0005829] cAMP binding [GO:0030552] YLPPLRIVQAIKAPR 1 2.6 0.52199 0.18712 0 0 3.83835 0 0 0 0 0 0 0 0 0 Q96M27 PRRC1_HUMAN Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) PRRC1 Homo sapiens (Human) epithelial structure maintenance [GO:0010669] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237] AIAGMYK;RQMIYSAAR;TGVIHEK 3 5.2 0.97879 -1.9044 0 0 0 0 8.82648 0 0 0 11.9093 0 0 0 Q96M29 TEKT5_HUMAN Tektin-5 TEKT5 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] LSDIGFWK 1 1.6 0.91404 -0.39033 0 0 0 0 0 0 0 11.3459 0 0 0 0 Q96M32 KAD7_HUMAN Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) AK7 Homo sapiens (Human) cell projection organization [GO:0030030] cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514] (d)CMP kinase activity [GO:0004127]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] DLFNQEDEEEEDDVR 1 2.1 0.78409 0.02666 0 0 0 0 0 0 0 0 0 0 0 7.23084 Q96M34 TEX55_HUMAN "Testis-specific expressed protein 55 (Testis-specific conserved, cAMP-dependent type II PK-anchoring protein)" TEX55 C3orf30 TSCPA Homo sapiens (Human) nucleus [GO:0005634] EEPPQEALAEPLK 1 2.4 0.88125 -0.15673 0 0 0 0 0 0 0 0 0 7.89548 0 0 Q96M42 CU129_HUMAN Putative uncharacterized protein encoded by LINC00479 LINC00479 C21orf129 PRED76 Homo sapiens (Human) LLIPRWR 1 4.9 0.68269 0.16423 8.36968 18.2099 17.9433 8.82899 15.2443 15.0388 17.4347 17.2606 17.3541 16.2348 16.2729 11.2175 Q96M53 TBATA_HUMAN "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA C10orf27 SPATIAL Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] ciliary basal body [GO:0036064]; cytosol [GO:0005829] ATDVQLADYPLMSPK;YSAETGR 2 6.3 0.94521 -0.64225 0 0 0 0 0 9.78906 0 0 0 0 0 0 Q96M60 F227B_HUMAN Protein FAM227B FAM227B C15orf33 Homo sapiens (Human) ECVASLSSSSSSSPSSTDNYNFEEEEY;ELSTTTIHGSK;FLHKLRSEAEIER;WKSMISETSSYRK 4 12.6 0.96574 -1.2577 7.98613 7.15289 0 0 0 0 0 11.8551 0 0 0 11.0908 Q96M63 ODAD1_HUMAN Outer dynein arm-docking complex subunit 1 (Coiled-coil domain-containing protein 114) ODAD1 CCDC114 Homo sapiens (Human) cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158] axoneme [GO:0005930]; cilium [GO:0005929]; outer dynein arm [GO:0036157]; outer dynein arm docking complex [GO:0120228] DLAAAAAKLDGTLSVDLASTQR;EVHQRINK;VLQQRMDK 3 5.7 0.83052 -0.02482 0 0 0 0 0 7.63154 0 0 0 0 7.59388 0 Q96M63 ODAD1_HUMAN Outer dynein arm-docking complex subunit 1 (Coiled-coil domain-containing protein 114) ODAD1 CCDC114 Homo sapiens (Human) cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158] axoneme [GO:0005930]; cilium [GO:0005929]; outer dynein arm [GO:0036157]; outer dynein arm docking complex [GO:0120228] EVHQRINK;GPVHLPCR;VGPAGVGPGLSVCRGPVHLPCR;VLQQRMDK 4 7.1 0.97381 -1.3991 0 0 0 9.73254 0 0 12.1322 12.2957 11.0373 8.1441 0 0 Q96M69 LRGUK_HUMAN Leucine-rich repeat and guanylate kinase domain-containing protein LRGUK Homo sapiens (Human) axoneme assembly [GO:0035082]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cell projection [GO:0042995]; cytosol [GO:0005829]; manchette [GO:0002177] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] TPAERDSIHR 1 1.2 0.8888 -0.18413 0 0 0 0 0 0 0 0 0 10.3807 0 0 Q96M78 FEAS2_HUMAN Putative uncharacterized protein encoded by FER1L6-AS2 (FER1L6 antisense RNA 2) (FER1L6 antisense gene protein 2) FER1L6-AS2 C8orf78 Homo sapiens (Human) EELHLLHFPNSPEENLRK 1 13.1 0.60291 0.17791 0 0 0 0 5.81198 5.67956 0 8.54485 0 0 0 0 Q96M83 CCDC7_HUMAN Coiled-coil domain-containing protein 7 (Protein BIOT2) CCDC7 BIOT2 C10orf68 Homo sapiens (Human) AKHQLNYFLNQEK;LEMQIEK;LEMQIEKTK;LIEKSSEK;LLNDEFKTQSK;TDKNFFAYATGRGLMK;VLHAAAR 7 4.6 0.97729 -5.7873 0 0 0 0 7.84743 0 0 0 0 8.11655 8.03936 11.5978 Q96M83 CCDC7_HUMAN Coiled-coil domain-containing protein 7 (Protein BIOT2) CCDC7 BIOT2 C10orf68 Homo sapiens (Human) AKHQLNYFLNQEK;ASGSFYSCRKVK;KVKWEQICHTLIMK 3 7 0.97516 -2.3738 0 0 0 0 0 0 12.0044 10.3172 0 0 0 0 Q96M85 YV008_HUMAN Putative uncharacterized protein FLJ32756 Homo sapiens (Human) LCSLKEQSILKIFTK 1 8.5 0.85902 -0.08232 0 0 0 0 0 0 0 0 0 0 10.3981 0 Q96M86 DNHD1_HUMAN Dynein heavy chain domain-containing protein 1 (Coiled-coil domain-containing protein 35) (Dynein heavy chain domain 1-like protein) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316] extracellular exosome [GO:0070062]; inner dynein arm [GO:0036156]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DALQAQREAFLEQMSK;EHGTHANLIFDLEQQLKDSGK;ITDSELIKLHLILK;LGYGCLLVLR;LLYKQQLEECR;LQRYWEAR;LVRVLARPRQHGLLLSGALGTGR;NHFSLFSAENEALDISVR;NVVRLWLHEAQRTFCDR;VFHLSAFRHPR;YLGVGADASSDVPERVFHLSAFRHPR 11 3.5 0.97742 -5.8884 0 0 0 12.3181 6.37097 5.80614 5.36328 0 10.8719 9.9181 0 0 Q96M89 CC138_HUMAN Coiled-coil domain-containing protein 138 CCDC138 Homo sapiens (Human) ITKQSFK;VGSSLKYSDESK 2 2.9 0.97067 -1.3358 0 0 0 0 0 0 0 0 0 0 8.05523 0 Q96M91 CFA53_HUMAN Cilia- and flagella-associated protein 53 (Coiled-coil domain-containing protein 11) CFAP53 CCDC11 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; manchette assembly [GO:1905198]; sperm flagellum assembly [GO:0120316] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; extracellular region [GO:0005576]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922] HENEQDMLKKQK;LAEKDKELR;LEKEARR;LVEEQMFSKLWEEDRLAK;RREFEAGVAANK 5 11.3 0.9768 -2.2033 0 0 0 0 9.86499 0 0 0 10.754 0 9.55589 5.55225 Q96M93 ADAD1_HUMAN Adenosine deaminase domain-containing protein 1 (Testis nuclear RNA-binding protein) ADAD1 TENR Homo sapiens (Human) adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251] VLHDTHAVVTARRSLLR 1 3 0.8504 -0.075963 0 0 0 0 0 0 7.3505 0 0 0 0 0 Q96M94 KLH15_HUMAN Kelch-like protein 15 KLHL15 KIAA1677 Homo sapiens (Human) negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ILLLKKPR;TRRTQVVTNCWENK;WEFVDPYPVNK 3 5.5 0.93817 -0.57385 0 0 0 3.1599 9.15894 0 9.78895 0 0 9.95414 0 0 Q96M95 CCD42_HUMAN Coiled-coil domain-containing protein 42 CCDC42 CCDC42A Homo sapiens (Human) acrosome assembly [GO:0001675]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; spermatid development [GO:0007286] centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm head-tail coupling apparatus [GO:0120212]; sperm principal piece [GO:0097228] HLKEVTEVALEDTHK;LQMRFDRAR 2 7.6 0.97946 -1.8988 0 0 3.99548 0 0 0 0 0 0 0 0 0 Q96M95 CCD42_HUMAN Coiled-coil domain-containing protein 42 CCDC42 CCDC42A Homo sapiens (Human) acrosome assembly [GO:0001675]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; spermatid development [GO:0007286] centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm head-tail coupling apparatus [GO:0120212]; sperm principal piece [GO:0097228] HLKEVTEVALEDTHK;YLEKVVENSEESR 2 11.6 0.88759 -0.18611 0 0 0 0 8.4818 0 8.37678 0 0 0 0 0 Q96M96 FGD4_HUMAN "FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)" FGD4 FRABP ZFYVE6 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] VGIDGMK 1 0.9 0.93345 -0.50223 0 0 0 0 0 0 0 0 0 9.49165 9.26887 0 Q96M98 PACRG_HUMAN Parkin coregulated gene protein (Molecular chaperone/chaperonin-binding protein) (PARK2 coregulated gene protein) PACRG GLUP Homo sapiens (Human) cellular response to unfolded protein [GO:0034620]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; spermatid development [GO:0007286] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; vesicle [GO:0031982] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] ILPVLPQLIIPIKNALNLR 1 6.4 0.92179 -0.43951 0 0 0 0 0 0 0 0 0 0 0 4.51671 Q96MA6 KAD8_HUMAN Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8) AK8 C9orf98 Homo sapiens (Human) ventricular system development [GO:0021591] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; sperm flagellum [GO:0036126] (d)CMP kinase activity [GO:0004127]; adenylate kinase activity [GO:0004017]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] HVIVLSAPDTVLIERNLGKR;LLQNPKDAEEQVK 2 6.9 0.93647 -0.52604 0 0 10.546 0 0 7.25238 0 0 0 0 0 0 Q96MC2 DRC1_HUMAN Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) DRC1 C2orf39 CCDC164 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of cilium movement [GO:0003352]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cytosol [GO:0005829]; sperm flagellum [GO:0036126] DDQYVKDLKK;ESEEDQSK;FDEITSKWEEGKQK;ILEAFVMGLKKPR;NVRDNSK 5 7 0.97511 -3.9691 0 12.2994 8.21028 11.906 0 9.1719 0 0 0 0 0 6.77597 Q96MC5 MERB1_HUMAN bMERB domain-containing protein 1 BMERB1 C16orf45 Homo sapiens (Human) cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; microtubule depolymerization [GO:0007019]; negative regulation of cell motility involved in cerebral cortex radial glia guided migration [GO:0021822]; negative regulation of microtubule depolymerization [GO:0007026] microtubule cytoskeleton [GO:0015630] DCCGATQCNIM 1 5.9 0.80702 0.007099 0 0 0 0 0 0 0 0 4.08194 0 0 0 Q96MC9 CA147_HUMAN Putative uncharacterized protein IKBKE-AS1 (IKBKE antisense RNA 1) (Uncharacterized protein C1orf147) IKBKE-AS1 C1orf147 Homo sapiens (Human) WVPGICLPR 1 3.3 0.91212 -0.32352 0 0 11.7317 0 0 0 0 0 0 0 0 0 Q96MD2 KICS2_HUMAN KICSTOR subunit 2 (KICSTOR complex protein C12orf66) KICS2 C12orf66 Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462] intercellular bridge [GO:0045171]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] VFASLKPGAK 1 2.2 0.94084 -0.58579 0 0 0 12.4064 0 0 0 0 0 0 0 0 Q96MD7 CI085_HUMAN Uncharacterized protein C9orf85 C9orf85 Homo sapiens (Human) CGKKEDIVIPWSLPLLPR;KCVKCLQK 2 14.5 0.84793 -0.062353 8.77304 0 0 0 0 0 6.37678 0 0 0 0 0 Q96ME1 FXL18_HUMAN F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) FBXL18 FBL18 Homo sapiens (Human) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] LAALCLDK 1 1.1 0.91375 -0.39033 0 0 0 0 0 0 0 12.4939 0 0 0 0 Q96ME7 ZN512_HUMAN Zinc finger protein 512 ZNF512 KIAA1805 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] QEEDEDYREFPQK;SQARRIR;SSRLGAVPATSGPTTFKQQR 3 7.1 0.97295 -1.3737 9.88324 8.8842 0 0 4.8844 0 0 10.2206 10.1051 0 0 0 Q96MF2 STAC3_HUMAN SH3 and cysteine-rich domain-containing protein 3 STAC3 Homo sapiens (Human) neuromuscular synaptic transmission [GO:0007274]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] FCDVCAR;KPKFCDVCARMIVLNNK;TNIHEHCQSYVEMQR 3 8.8 0.87419 -0.11353 0 7.41591 0 0 0 0 0 0 7.3505 0 0 5.29319 Q96MF6 CQ10A_HUMAN "Coenzyme Q-binding protein COQ10 homolog A, mitochondrial" COQ10A UNQ6192/PRO20219 Homo sapiens (Human) cellular respiration [GO:0045333] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ubiquinone binding [GO:0048039] LAPLSFGLRFLTSCSLLLPR 1 8.7 0.88762 -0.19024 0 0 0 9.93748 0 0 0 0 0 0 0 0 Q96MG2 JSPR1_HUMAN Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) JSRP1 JP45 Homo sapiens (Human) skeletal muscle contraction [GO:0003009] sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] AEAEVRPK;IPGSREAAENDEEEPGEATGEAVREDR 2 10.6 0.92715 -0.45667 0 0 0 0 0 0 0 0 0 7.00383 0 0 Q96MG7 NSE3_HUMAN Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) NSMCE3 HCA4 MAGEG1 NDNL2 Homo sapiens (Human) cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" protein dimerization activity [GO:0046983] VLRDGFAEEAPSTSR;VSELVQFLLIKDQKK 2 9.9 0.93324 -0.50699 0 8.98288 3.99186 0 0 0 0 0 0 0 0 0 Q96MG8 PCMD1_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 PCMTD1 Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; membrane [GO:0016020] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AYLTYFR 1 2 0.91105 -0.319 0 0 0 0 0 0 0 0 0 8.68538 0 0 Q96MH2 HEXI2_HUMAN Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) HEXIM2 L3 Homo sapiens (Human) negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; snRNA binding [GO:0017069] DERQSQRASR 1 3.5 0.97569 -1.4639 0 0 0 9.77414 10.2833 0 0 0 0 0 0 0 Q96MI9 CBPC4_HUMAN Cytosolic carboxypeptidase 4 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 1) (Protein deglutamylase CCP4) AGBL1 CCP4 Homo sapiens (Human) C-terminal protein deglutamylation [GO:0035609]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] SPVVFCDFHGHSQK;STVHLGSKK 2 2.1 0.36075 0.23272 7.80626 11.5961 0 0 0 0 0 0 0 0 0 0 Q96MK2 RIPR3_HUMAN RIPOR family member 3 RIPOR3 C20orf175 C20orf176 FAM65C Homo sapiens (Human) ALLFYTNALAENDAR;ELEYQVLGFR;LAFEKMDKLCSEQR;LAFYYDLDKQTR;LASPNLSR;LGRQRWK;MDKLCSEQR 7 7 0.97748 -5.8643 0 0 0 10.1495 10.2188 0 0 5.96915 0 0 5.6173 0 Q96MK3 FA20A_HUMAN Pseudokinase FAM20A FAM20A UNQ9388/PRO34279 Homo sapiens (Human) biomineral tissue development [GO:0031214]; calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] protein serine/threonine kinase activator activity [GO:0043539] IVNVTKEILEVTK;LVLRFSDFGKAMFKPMR 2 5.5 0.91091 -0.31909 0 0 0 0 0 0 7.99192 0 0 7.06652 0 8.97891 Q96MM3 ZFP42_HUMAN Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754) ZFP42 REX1 ZNF754 Homo sapiens (Human) female gonad development [GO:0008585]; male gonad development [GO:0008584]; meiotic cell cycle [GO:0051321]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FSLDFNLR;NRAALRK 2 4.8 0.96665 -1.2784 0 11.0105 0 0 0 0 0 0 0 0 0 0 Q96MM6 HS12B_HUMAN Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B) HSPA12B C20orf60 Homo sapiens (Human) ATP binding [GO:0005524] FVAAEQSVALGEEVR;SIDSSFRQAREQLR;VTAVDVSTNR 3 5.7 0.93621 -0.52689 0 0 0 0 8.66622 0 0 11.1689 0 0 0 0 Q96MM7 H6ST2_HUMAN Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2) (EC 2.8.2.-) HS6ST2 PSEC0092 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139] heparan sulfate 6-O-sulfotransferase activity [GO:0017095] ALPACAVR;DLFLQRYQFMR;GVSHGFHTRPLLDKPR;IFQILDAASKDKR;SEDESSARFVPR 5 9.3 0.97622 -2.2986 0 5.84373 12.5056 9.93593 0 0 0 0 7.48196 0 10.8843 0 Q96MN2 NALP4_HUMAN "NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)" NLRP4 NALP4 PAN2 PYPAF4 RNH2 Homo sapiens (Human) inflammatory response [GO:0006954]; negative regulation of innate immune response [GO:0045824]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090] KFKEHLK;LVYFCCFFK;RAMEAFNLVR;TLCEALK 4 3.3 0.98112 -1.7838 0 0 0 0 7.58263 0 10.4558 9.51126 6.6761 0 12.1581 0 Q96MN9 ZN488_HUMAN Zinc finger protein 488 ZNF488 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] KEHAGPDPHSQK 1 3.5 0.91539 -0.43415 0 0 0 0 0 0 0 0 0 0 0 11.6632 Q96MP5 ZSWM3_HUMAN Zinc finger SWIM domain-containing protein 3 ZSWIM3 C20orf164 Homo sapiens (Human) zinc ion binding [GO:0008270] SQKTMCLQR;VQVSSKPEQEGITPSDLAK 2 4 0.97775 -1.5135 0 0 0 0 0 0 11.7505 0 0 0 0 0 Q96MR6 CFA57_HUMAN Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65) CFAP57 WDR65 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] ELQDMECCNNQK;FAEGTLKQTSFQR;IIEMQRLEIQR;LLLEYEK;QDVYHHEHIEDLLDK;SQGMLALSISPNR;VLLFEKMEEKDFYR 7 6.8 0.80994 0.009318 11.9121 12.5727 13.1317 10.6916 11.1369 10.8485 10.8664 0 0 8.90084 10.5578 0 Q96MR7 OBAS1_HUMAN Putative uncharacterized protein OBSCN-AS1 (OBSCN antisense RNA 1) (OBSCN antisense gene protein 1) OBSCN-AS1 C1orf145 Homo sapiens (Human) ALRPAQSCRSGPR 1 8.2 0.94138 -0.61416 0 0 0 0 0 0 0 0 0 12.1108 0 0 Q96MR9 ZN560_HUMAN Zinc finger protein 560 ZNF560 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DVMLENYENVAK;HQTSVSALQQEFWK;IKPYKCKDCGK;TLNGIQLAR 4 5.8 0.98019 -1.6508 0 8.37964 0 0 0 0 10.7621 0 0 0 0 8.39896 Q96MS0 ROBO3_HUMAN Roundabout homolog 3 (Roundabout-like protein 3) ROBO3 Homo sapiens (Human) axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; chemotaxis [GO:0006935]; commissural neuron axon guidance [GO:0071679]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; positive regulation of axon guidance [GO:1902669] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] FHLNRSAAGWAR;GSCCPSNPDPDDR;SPSAQEPR 3 2.4 0.97447 -2.4083 0 0 0 0 0 0 0 0 0 8.93106 0 10.6304 Q96MS3 GL1D1_HUMAN Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) GLT1D1 Homo sapiens (Human) cytosol [GO:0005829]; extracellular region [GO:0005576] glycosyltransferase activity [GO:0016757] EIVVNGREYVR 1 4.1 0.88569 -0.18094 0 0 0 0 0 0 0 0 0 9.48508 0 0 Q96MS3 GL1D1_HUMAN Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) GLT1D1 Homo sapiens (Human) cytosol [GO:0005829]; extracellular region [GO:0005576] glycosyltransferase activity [GO:0016757] NTVMGRVLEEASR;VLEEASRMLR 2 10.5 0.91731 -0.36029 0 0 0 0 0 0 11.2802 0 0 10.074 0 0 Q96MT0 YJ006_HUMAN Putative uncharacterized protein FLJ31958 Homo sapiens (Human) SIGTSQIFLERHRSPLK 1 10.4 0.9644 -1.1171 0 0 0 0 0 0 0 0 9.36359 0 0 0 Q96MT1 RN145_HUMAN RING finger protein 145 (EC 2.3.2.27) RNF145 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] HRDRISPSNSPTWSLQVFSK 1 2.9 0.95824 -1.0029 11.8363 0 11.6545 10.5809 0 0 0 11.1948 0 11.7391 0 0 Q96MT3 PRIC1_HUMAN Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) PRICKLE1 RILP Homo sapiens (Human) "anterior visceral endoderm cell migration [GO:1905070]; aorta development [GO:0035904]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; cardiac muscle cell development [GO:0055013]; cell-cell adhesion [GO:0098609]; cilium assembly [GO:0060271]; cornea development in camera-type eye [GO:0061303]; coronary vasculature development [GO:0060976]; cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite development [GO:0016358]; embryonic brain development [GO:1990403]; embryonic nail plate morphogenesis [GO:0035880]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; extracellular matrix assembly [GO:0085029]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; focal adhesion disassembly [GO:0120181]; gene expression [GO:0010467]; maintenance of postsynaptic density structure [GO:0099562]; mesenchyme development [GO:0060485]; mitotic spindle assembly [GO:0090307]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell myoblast differentiation [GO:2000691]; negative regulation of DNA-templated transcription [GO:0045892]; neural tube closure [GO:0001843]; neuron projection extension [GO:1990138]; outflow tract morphogenesis [GO:0003151]; polarized secretion of basement membrane proteins in epithelium [GO:0061865]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein import into nucleus [GO:0006606]; regulation of postsynaptic density assembly [GO:0099151]; renal tubule development [GO:0061326]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; tear secretion [GO:0070075]; tissue homeostasis [GO:0001894]; vesicle-mediated transport [GO:0016192]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cell trailing edge [GO:0031254]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; proteasome complex [GO:0000502] protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270] CSACDEIIFADECTEAEGR;LRLYTPDNYEKFIQNK 2 4.2 0.88517 -0.1942 0 0 0 0 0 0 0 0 0 0 8.81542 9.58199 Q96MT7 CFA44_HUMAN Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52) CFAP44 WDR52 Homo sapiens (Human) cell morphogenesis [GO:0000902]; microtubule cytoskeleton organization [GO:0000226]; nucleus organization [GO:0006997]; sperm axoneme assembly [GO:0007288] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] peptidase activity [GO:0008233] AEPTDVELEIMKR;AFSQEVFKVTFNPDK;AYSIENAR;DSISRSSKASTFSLDIPK;ELVVTFDAELR;ELVVTFDAELRLLRHQK;IVATNLNAAEEALEAYQREK;KDGDLTTRDSISR;KLDSRLNTLQNQQGNAFQGPR;KNEITKLQEQEK;LNTLQNQQGNAFQGPR;NEITKLQEQEK;QQQMKSKDEK;TDFDVDSQIRAEMHR;TRKLILK;VAVVEEIQCLVQELKNIQSTLHISKHIPIPK 16 10.5 0.9758 -4.4276 10.9705 9.86663 11.8108 9.51088 11.4305 0 5.49656 7.59783 0 10.1007 0 0 Q96MT8 CEP63_HUMAN Centrosomal protein of 63 kDa (Cep63) CEP63 Homo sapiens (Human) cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein stabilization [GO:0050821]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922] molecular adaptor activity [GO:0060090] EALLEGIQNR;EESLAEKK;LVSENQQLQK 3 4 0.89482 -0.24278 0 0 0 0 0 7.87486 0 8.9484 0 0 0 5.93605 Q96MU6 ZN778_HUMAN Zinc finger protein 778 ZNF778 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASSHLHK 1 1 0.9407 -0.58708 0 0 0 0 0 0 8.95321 0 0 0 0 0 Q96MU7 YTDC1_HUMAN YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) "dosage compensation by inactivation of X chromosome [GO:0009048]; in utero embryonic development [GO:0001701]; mRNA alternative polyadenylation [GO:0110104]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; primary follicle stage [GO:0048160]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] IDWICRR;LCDRDRDR 2 2.1 0.98108 -1.6912 0 0 0 0 0 0 0 0 0 0 0 10.1938 Q96MU8 KREM1_HUMAN Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose) KREMEN1 KREMEN KRM1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell communication [GO:0007154]; limb development [GO:0060173]; negative regulation of axon regeneration [GO:0048681]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] LTIQTCISFCR;NPLAIQDSEVTSLIWSQGQPR 2 6.5 0.54814 0.1838 0 4.24443 0 0 0 0 0 0 9.8202 0 0 0 Q96MV1 TLCD4_HUMAN TLC domain-containing protein 4 (Transmembrane protein 56) TLCD4 TMEM56 Homo sapiens (Human) lipid homeostasis [GO:0055088] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] FSKAIVINGILMTVVFFIVR;ISKGCIK 2 10.3 0.96574 -1.2458 0 0 0 0 0 0 0 0 0 11.1958 4.59084 0 Q96MV8 ZDH15_HUMAN Palmitoyltransferase ZDHHC15 (EC 2.3.1.225) (Acyltransferase ZDHHC15) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 15) (DHHC-15) ZDHHC15 UNQ1969/PRO4501 Homo sapiens (Human) peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to postsynapse [GO:0062237]; protein palmitoylation [GO:0018345]; protein targeting to Golgi apparatus [GO:0140450]; protein targeting to membrane [GO:0006612]; regulation of dendritic spine morphogenesis [GO:0061001]; synaptic vesicle maturation [GO:0016188] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270] LPVYTRTGSGGQFIQR;QMLVDMAK;QMLVDMAKK 3 17.5 0.91541 -0.39201 11.4811 8.68324 0 0 0 0 0 0 0 0 9.11294 0 Q96MW1 CCD43_HUMAN Coiled-coil domain-containing protein 43 CCDC43 Homo sapiens (Human) cytosol [GO:0005829] NTNVEDVLNARK 1 5.4 0.92385 -0.44964 0 0 0 9.90022 9.7252 0 0 0 0 0 0 0 Q96MW5 COG8_HUMAN Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) COG8 Homo sapiens (Human) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588] AQLLQQTR;DLAFANYKTFIR;VAISTFQK 3 4.6 0.97326 -2.6512 0 0 0 0 0 0 0 0 0 10.6407 0 10.1721 Q96MW7 TIGD1_HUMAN Tigger transposable element-derived protein 1 TIGD1 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677] AAAGFER;FKERSHFHNIK;SHFHNIKAQGEAASADVEAAASYPEALAK;TLTDEELFLMDAQRK 4 9.3 0.95232 -0.77012 0 0 0 0 0 0 0 10.0496 0 0 0 5.91865 Q96MX0 CKLF3_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 3 (Chemokine-like factor superfamily member 3) CMTM3 CKLFSF3 Homo sapiens (Human) blastocyst hatching [GO:0001835]; chemotaxis [GO:0006935]; positive regulation of B cell receptor signaling pathway [GO:0050861] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear membrane [GO:0031965] cytokine activity [GO:0005125] TEEENSDSDSD 1 6 0.80721 0.007099 0 0 0 0 0 0 0 0 0 4.66437 0 0 Q96MX0 CKLF3_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 3 (Chemokine-like factor superfamily member 3) CMTM3 CKLFSF3 Homo sapiens (Human) blastocyst hatching [GO:0001835]; chemotaxis [GO:0006935]; positive regulation of B cell receptor signaling pathway [GO:0050861] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear membrane [GO:0031965] cytokine activity [GO:0005125] GPGGFVCTWCSCPHQPLW 1 30.5 0.78484 0.018395 0 0 0 7.22699 0 0 0 0 0 0 0 0 Q96MX3 ZNF48_HUMAN Zinc finger protein 48 (Zinc finger protein 553) ZNF48 ZNF553 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AATAATQGPK;VKHLRTHR 2 2.9 0.93758 -0.56001 0 0 0 0 0 10.5962 0 0 0 0 0 0 Q96MX6 DAA10_HUMAN Dynein axonemal assembly factor 10 (WD repeat-containing protein 92) (WD repeat-containing protein Monad) DNAAF10 WDR92 Homo sapiens (Human) apoptotic process [GO:0006915]; axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821] dynein axonemal particle [GO:0120293]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] ubiquitin binding [GO:0043130] LLREIEKAKPIK;QKDDPVANMEPVQGENK 2 8.1 0.98048 -1.7212 0 0 0 0 0 0 5.37567 0 0 0 0 0 Q96MY1 NOL4L_HUMAN Nucleolar protein 4-like NOL4L C20orf112 C20orf113 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] APTADDDDDDHDDHEDNDK;EKIQAIIESCSR 2 7.1 0.90994 -0.2824 0 0 4.45766 0 0 6.09504 0 0 0 0 3.81455 0 Q96MY7 F161B_HUMAN Protein FAM161B FAM161B C14orf44 Homo sapiens (Human) cilium organization [GO:0044782] cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630] IKDFPRFQETTK;KSQAMSK;LGFLHTNFR;QFRAQPVPAHVYLPLYQEIMERSEAR 4 8.3 0.96504 -1.15 0 2.65143 5.63546 10.3163 0 9.94009 0 2.6785 0 0 9.65182 11.3959 Q96MZ0 GD1L1_HUMAN Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1-L1) GDAP1L1 Homo sapiens (Human) mitochondrion [GO:0005739] GLVCEER;GQLGRAQ;TFTGGPR 3 14.3 0.9554 -0.82844 8.42114 0 0 0 0 0 7.94234 7.89093 8.43888 0 0 0 Q96MZ4 F218A_HUMAN Protein FAM218A FAM218A C4orf39 Homo sapiens (Human) RGSCPLLPGPSAWR 1 8.9 0.87772 -0.13677 0 0 0 0 0 0 0 0 0 6.72738 0 0 Q96N03 VTM2L_HUMAN V-set and transmembrane domain-containing protein 2-like protein VSTM2L C20orf102 Homo sapiens (Human) negative regulation of neuron apoptotic process [GO:0043524] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] VPRHRLQR 1 6.1 0.9776 -1.5135 0 0 0 0 0 0 0 0 0 0 9.34574 0 Q96N16 JKIP1_HUMAN Janus kinase and microtubule-interacting protein 1 (GABA-B receptor-binding protein) (Multiple alpha-helices and RNA-linker protein 1) (Marlin-1) JAKMIP1 GABABRBP JAMIP1 MARLIN1 Homo sapiens (Human) cognition [GO:0050890]; protein transport [GO:0015031] cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; ribonucleoprotein complex [GO:1990904] GABA receptor binding [GO:0050811]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; RNA binding [GO:0003723] EALDEQLVQVKEAER;LDILGDNGNLR;LLLQKEALDEQLVQVK;LQEAKLEREQEQR;VILALEK 5 6.1 0.9735 -1.4178 9.62801 0 0 0 0 9.18879 0 0 0 0 8.65127 0 Q96N16 JKIP1_HUMAN Janus kinase and microtubule-interacting protein 1 (GABA-B receptor-binding protein) (Multiple alpha-helices and RNA-linker protein 1) (Marlin-1) JAKMIP1 GABABRBP JAMIP1 MARLIN1 Homo sapiens (Human) cognition [GO:0050890]; protein transport [GO:0015031] cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; ribonucleoprotein complex [GO:1990904] GABA receptor binding [GO:0050811]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; RNA binding [GO:0003723] EALDEQLVQVKEAER;EEADLRFCQLTREDLQAAVEK;LLLQKEALDEQLVQVK;LQEAKLEREQEQR;VILALEK 5 10.7 0.86417 -0.083824 0 0 0 0 0 0 0 0 0 0 0 8.66615 Q96N19 G137A_HUMAN Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein) GPR137 C11orf4 GPR137A TM7SF1L1 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] lysosomal membrane [GO:0005765] TTLFSFYFRDTPRANR 1 3.8 0.44913 0.19164 0 0 0 0 7.94615 0 0 0 0 0 0 0 Q96N20 ZN75A_HUMAN Zinc finger protein 75A ZNF75A Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" FRWSSDLNK;VGKWHQDFPVKK 2 7.1 0.98047 -1.6677 0 0 0 0 0 0 11.9795 0 0 0 0 0 Q96N21 AP4AT_HUMAN AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) TEPSIN C17orf56 ENTHD2 Homo sapiens (Human) coated vesicle membrane [GO:0030662]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; trans-Golgi network membrane [GO:0032588] protein-containing complex binding [GO:0044877] IPGGTDSPKR;LSFLHRLPILLK 2 4.2 0.9672 -1.2989 10.965 0 0 0 0 0 0 0 0 0 0 0 Q96N22 ZN681_HUMAN Zinc finger protein 681 ZNF681 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKAFNQSSNLTGHK;YGKCEHENLQLSK 2 4.3 0.95571 -0.88151 0 0 3.15215 0 2.05735 0 0 8.6315 0 8.53025 0 0 Q96N23 CFA54_HUMAN Cilia- and flagella-associated protein 54 CFAP54 C12orf55 C12orf63 Homo sapiens (Human) cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; extracellular region [GO:0005576] AEGSYGK;EIQELLGFMRK;IFLYCRR;KTQTKVDITWILLLR;NFIGKQLK 5 1.6 0.97846 -2.1495 0 0 0 8.41777 5.68963 9.79849 0 0 0 0 0 0 Q96N38 ZN714_HUMAN Zinc finger protein 714 ZNF714 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFYHSSHLTTHK;FSTLTRHKR;IIHSGEK;QDPITSLEQEK 4 7 0.97944 -1.998 0 0 0 0 0 9.04579 0 0 11.7081 0 0 0 Q96N46 TTC14_HUMAN Tetratricopeptide repeat protein 14 (TPR repeat protein 14) TTC14 KIAA1980 UNQ5813/PRO19630 Homo sapiens (Human) nucleic acid binding [GO:0003676] DFYNSYKTQAGSSK;EDNYGEDIK;SEDPRDFYNSYK;SLELREKQAEK 4 5.1 0.97912 -1.5324 5.51425 0 0 10.8238 0 0 8.47379 7.58939 0 8.69248 0 0 Q96N58 ZN578_HUMAN Zinc finger protein 578 ZNF578 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;HESYHTGDFCFQEIEK;SFQCNETGEAFNCSSFVRK;SNLERHK;YLARHRR 5 10 0.96632 -1.1257 0 0 0 0 0 7.22728 5.80191 0 0 0 6.74752 0 Q96N64 PWP2A_HUMAN PWWP domain-containing protein 2A PWWP2A KIAA1935 MST101 Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NuRD complex binding [GO:0120325] NESVTTVNKK;TICVGDIVWAK 2 2.8 0.95335 -0.7325 0 0 0 0 9.77474 0 13.679 0 0 0 0 0 Q96N66 MBOA7_HUMAN Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7) MBOAT7 BB1 LENG4 OACT7 Homo sapiens (Human) layer formation in cerebral cortex [GO:0021819]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of triglyceride metabolic process [GO:0090207]; ventricular system development [GO:0021591] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; O-acyltransferase activity [GO:0008374] AASQPTSLAPEK;EDAFYARPLPAR;LSPGGQKAWDWVHWFLKMR 3 9.1 0.96701 -1.3101 0 0 0 0 0 0 10.7956 0 0 0 10.0992 10.5279 Q96N67 DOCK7_HUMAN Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; basal part of cell [GO:0045178]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; neuron projection [GO:0043005] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] FGEDVVEVIK;FLADMRRPSSVLR;IPQLYKAVLPVTCHRDSFSR;KVINMVHNLLSSHDSDPR;LNTSLAFFLNDLLSVMDR;MFGTYFR;QVSSKLYSLPNPSVLVSLR;TILTYAEEDLELR;VLLHSMACNQSAVYLQHCFATQR 9 6.6 0.91698 -0.41859 0 0 11.5441 0 0 9.7522 9.36407 3.04443 0 9.52822 9.60702 12.3942 Q96N68 CR015_HUMAN Putative uncharacterized protein C18orf15 C18orf15 Homo sapiens (Human) membrane [GO:0016020] QGQGALK 1 3.9 0.82256 -0.017925 16.9521 10.5788 0 0 0 0 0 0 0 0 0 0 Q96N76 HUTU_HUMAN Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase) UROC1 Homo sapiens (Human) L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] cytosol [GO:0005829] urocanate hydratase activity [GO:0016153] LVITNGMVIPNYSSR 1 2.2 0.78052 0.032593 0 0 0 0 0 0 0 0 12.0315 0 0 0 Q96N77 ZN641_HUMAN Zinc finger protein 641 ZNF641 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HQKTHLHDKTSR 1 2.7 0.59805 0.17849 0 0 0 0 0 0 0 0 8.62585 0 0 0 Q96N87 S6A18_HUMAN Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) SLC6A18 B0AT3 XTRP2 Homo sapiens (Human) amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; renal amino acid absorption [GO:1990297]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid:sodium:chloride symporter activity [GO:0140931] QEKLYPGWAR;VAQLPLK 2 2.7 0.96556 -1.1348 8.50629 7.36868 0 0 0 0 0 0 0 0 0 0 Q96N95 ZN396_HUMAN Zinc finger protein 396 (Zinc finger and SCAN domain-containing protein 14) ZNF396 ZSCAN14 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CPRSLSGGR;QIFFGRRK 2 5.1 0.98109 -1.7546 0 0 0 0 0 9.80679 0 0 9.09474 0 0 0 Q96N96 SPT13_HUMAN Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) SPATA13 Homo sapiens (Human) cell migration [GO:0016477]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; podosome [GO:0002102]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802] EIMDTERVYIK;EIMDTERVYIKHLR;EMGMEISENQKKLAMLNAQK;HRHCENKQQMR;LVSNVTEAAWR;VQEDKEMGMEISENQKK 6 4.8 0.95179 -0.70092 9.20726 9.10852 0 0 5.69725 0 0 5.91047 0 0 0 10.7768 Q96NA2 RILP_HUMAN Rab-interacting lysosomal protein RILP PP10141 Homo sapiens (Human) cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; intralumenal vesicle formation [GO:0070676]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; protein-containing complex [GO:0032991] dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] AAQDRER;ELLTDHR;VFLLKEELAYFQR;VPGLLLEAMK 4 9.2 0.97662 -2.241 0 0 12.4923 0 7.61853 0 0 0 0 0 9.30968 0 Q96NA8 TSNA1_HUMAN t-SNARE domain-containing protein 1 TSNARE1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] endomembrane system [GO:0012505]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] GGGLGSR;SRALLPMAQRGSK 2 3.9 0.96656 -1.2827 0 0 0 0 0 0 0 0 0 9.2206 0 0 Q96NB1 CEP20_HUMAN Centrosomal protein 20 (FGFR1OP N-terminal-like protein) (FOP-related protein of 20 kDa) (LisH domain-containing protein FOPNL) CEP20 C16orf63 FOPNL FOR20 PHSECRG2 Homo sapiens (Human) cilium assembly [GO:0060271]; microtubule anchoring [GO:0034453] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802] GVLGHLK 1 4 0.90865 -0.30954 0 0 0 0 0 0 0 0 0 0 0 8.2596 Q96NB2 SFXN2_HUMAN Sideroflexin-2 SFXN2 Homo sapiens (Human) mitochondrial transmembrane transport [GO:1990542]; serine import into mitochondrion [GO:0140300] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] AAAIGITQVVISR;LEKLHFMQK;MGVVPPGTQVEQLLYAK 3 12.1 0.98058 -1.5989 0 0 0 0 6.03122 0 0 0 0 0 0 10.3724 Q96NB3 ZN830_HUMAN Zinc finger protein 830 (Coiled-coil domain-containing protein 16) ZNF830 CCDC16 Homo sapiens (Human) blastocyst growth [GO:0001832]; cell division [GO:0051301]; chromosome organization [GO:0051276]; intestinal epithelial structure maintenance [GO:0060729]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic DNA replication checkpoint signaling [GO:0033314]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; nuclear DNA replication [GO:0033260]; ovarian follicle development [GO:0001541]; preantral ovarian follicle growth [GO:0001546]; RNA processing [GO:0006396]; RNA splicing [GO:0008380] chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] APDADDQDVKRAK 1 3.5 0.86453 -0.088076 0 0 0 0 0 0 0 10.3786 0 0 0 0 Q96NC0 ZMAT2_HUMAN Zinc finger matrin-type protein 2 ZMAT2 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ASGSGTK;QKDYDFEER 2 8 0.91526 -0.36984 0 0 0 0 9.38461 0 0 0 0 7.2503 0 0 Q96ND8 ZN583_HUMAN Zinc finger protein 583 (Zinc finger protein L3-5) ZNF583 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NSEFSSK;SVEMKHRK;VYVEKKLLK 3 4.2 0.9779 -1.9506 0 0 0 5.91389 0 0 0 0 0 0 0 0 Q96NE9 FRMD6_HUMAN FERM domain-containing protein 6 (Willin) FRMD6 C14orf31 Homo sapiens (Human) apical constriction [GO:0003383]; positive regulation of hippo signaling [GO:0035332]; protein localization [GO:0008104]; regulation of actin filament-based process [GO:0032970] apical junction complex [GO:0043296]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] LIYYTGCPMRSR;LIYYTGCPMRSRHLLQLLSNSHR;LYKYCPKEWK 3 5.3 0.98103 -1.5769 8.32724 0 8.52896 8.67274 0 8.65818 0 0 0 0 0 0 Q96NG3 ODAD4_HUMAN Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25) ODAD4 TTC25 Homo sapiens (Human) brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart development [GO:0007507]; lung development [GO:0030324]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228] FQQAIDTWEEK;QQKPIYARERDR;TQFGEIGETKKTGNEMEK;VLKKVLEWNK 4 7.6 0.073052 0.41651 0 10.1983 0 0 0 0 0 8.24531 0 0 5.52507 0 Q96NG3 ODAD4_HUMAN Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25) ODAD4 TTC25 Homo sapiens (Human) brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart development [GO:0007507]; lung development [GO:0030324]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228] SLWQKPPWR;SPSSVPR 2 5.5 0.95236 -0.71853 10.3362 10.3367 10.1943 0 0 0 14.9689 8.45812 0 0 0 0 Q96NG8 ZN582_HUMAN Zinc finger protein 582 ZNF582 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ISHLKVHYRIHTGEKPYACK;THTGEKPYQCKECGKAFNR 2 7.5 0.96688 -1.3004 0 8.04587 0 0 0 0 0 0 0 0 5.38031 0 Q96NH3 BROMI_HUMAN Protein broad-minded (TBC1 domain family member 32) TBC1D32 BROMI C6orf170 C6orf171 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; retinal pigment epithelium development [GO:0003406]; roof of mouth development [GO:0060021]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831] cilium [GO:0005929]; cytoplasm [GO:0005737] DFIIDGLSVER;LIILNSEAK;TGAINECVTFIFNR 3 2.7 0.93339 -0.50869 0 0 0 0 7.26209 0 0 0 0 7.53263 0 10.4341 Q96NI6 LRFN5_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 5 LRFN5 C14orf146 SALM5 Homo sapiens (Human) negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage activation [GO:0043031]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] ATLRCKAR;MEKILFYLFLIGIAVKAQICPK 2 4.2 0.74492 0.087595 0 0 0 0 0 0 0 0 0 6.13025 0 7.61464 Q96NI8 ZN570_HUMAN Zinc finger protein 570 ZNF570 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSQFAYLAQHQRVHTGEKPYECIECGK;AFSQIAYLAQHQR 2 7.6 0.9176 -0.39919 0 0 0 0 0 7.20936 0 0 0 0 0 8.49013 Q96NJ3 ZN285_HUMAN Zinc finger protein 285 (Zinc finger protein 285A) ZNF285 ZNF285A Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GFGFRSLLCIHQGVHTGK 1 3.1 0.91576 -0.43242 0 0 0 0 0 0 0 0 0 0 0 10.6005 Q96NJ5 KLH32_HUMAN Kelch-like protein 32 (BTB and kelch domain-containing protein 5) KLHL32 BKLHD5 KIAA1900 Homo sapiens (Human) FQSDTLYIIGGKKR;LMVYEPNQNK 2 3.9 0.9526 -0.75996 0 0 0 0 0 0 0 0 0 4.68122 0 0 Q96NJ6 ZFP3_HUMAN Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752) ZFP3 ZNF752 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GFGQSSELIR;IHTGEKPYECFECGK;MGTENKEVIPK;TQRSSVGEKPHTCK 4 10 0.93656 -0.55565 0 9.86216 0 0 0 0 8.06975 9.83298 8.29843 0 7.13914 12.138 Q96NL0 RUN3B_HUMAN RUN domain-containing protein 3B (Rap2-binding protein 9) (Rap2-interacting protein 9) (RPIP-9) RUNDC3B RPIB9 RPIP9 Homo sapiens (Human) HLSEYISTALR;LRENQLSESVSQNK 2 5.3 0.97645 -2.199 0 0 0 0 0 0 0 0 0 0 11.8561 0 Q96NL1 TMM74_HUMAN Transmembrane protein 74 TMEM74 Homo sapiens (Human) "general adaptation syndrome, behavioral process [GO:0051867]; macroautophagy [GO:0016236]" autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] ESAKLYGSFNFRMK 1 4.6 0.86512 -0.085122 0 0 0 0 0 0 0 0 0 0 10.2658 0 Q96NL3 ZN599_HUMAN Zinc finger protein 599 ZNF599 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFTQPANFVR;LYECGECGKAFTHR 2 4.1 0.95564 -0.93282 0 0 0 0 9.75131 0 0 0 0 0 0 4.80111 Q96NL6 SCLT1_HUMAN Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1) SCLT1 SAP1 Homo sapiens (Human) cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; clathrin complex [GO:0071439]; cytosol [GO:0005829] clathrin binding [GO:0030276]; sodium channel regulator activity [GO:0017080] ENCGLVSEQRLKLQQENK;FVQDATIRTK;ISTMEHEFSIK;LQNVLESER;MAAEIDFLR;YQEMIQK 6 9.3 0.98171 -1.7702 4.59461 0 0 9.73435 8.76716 0 6.69864 0 0 0 5.88411 10.8039 Q96NM4 TOX2_HUMAN TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) TOX2 C20orf100 GCX1 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713] ALAAYRASLVSK 1 2.4 0.92342 -0.44821 0 0 0 0 0 0 9.96795 0 0 0 0 0 Q96NN9 AIFM3_HUMAN Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) execution phase of apoptosis [GO:0097194] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]" ALMKMFENNR;EVELGWGK;TPEDANRVVRLAR 3 5.1 0.96519 -1.2382 0 0 10.3079 0 8.66871 0 0 0 0 11.7796 0 0 Q96NR3 PTHD1_HUMAN Patched domain-containing protein 1 PTCHD1 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794] dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; synapse [GO:0045202] ISWFESYLNYLR;LHAAVTK 2 2.1 0.91755 -0.42455 0 0 0 0 0 0 0 0 0 0 12.2147 4.45332 Q96NR8 RDH12_HUMAN Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) RDH12 SDR7C2 Homo sapiens (Human) cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342] 11-cis-retinol dehydrogenase activity [GO:0102354]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650] KFFAGGVCR 1 2.8 0.91667 -0.42583 0 0 15.3034 0 0 0 0 0 0 0 0 0 Q96NT0 CC115_HUMAN Coiled-coil domain-containing protein 115 CCDC115 Homo sapiens (Human) cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; vacuolar proton-transporting V-type ATPase complex [GO:0016471] unfolded protein binding [GO:0051082] MAALDLR;TVLNARVEEGWLSLAKAR 2 13.9 0.74455 0.09212 0 10.1935 0 0 0 0 0 0 7.37894 0 0 0 Q96NT3 GUCD1_HUMAN Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) GUCD1 C22orf13 LLN4 Homo sapiens (Human) liver regeneration [GO:0097421]; response to cAMP [GO:0051591] YCCFTPSGHHCFCR 1 5.8 0.69329 0.16223 0 0 0 6.79675 0 0 0 0 0 0 0 0 Q96NU0 CNT3B_HUMAN Contactin-associated protein-like 3B (Cell recognition molecule Caspr3b) CNTNAP3B CASPR3B Homo sapiens (Human) cell adhesion [GO:0007155] membrane [GO:0016020] ELAPRLAGGAGRSGPVDEGEPLVNADR;FLPLAWNPR;LAGGAGR 3 2.8 0.89778 -0.25339 0 0 0 10.0975 0 9.72969 0 8.54353 0 0 0 0 Q96NW4 ANR27_HUMAN Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) ANKRD27 PP12899 Homo sapiens (Human) early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031] cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149] DTVQKMCHPLCFCDDCEK;LKETPLK;MCHPLCFCDDCEK;MCHPLCFCDDCEKLVSGR;WNSKLYDLPDEPFTR 5 4.3 0.97834 -2.1032 0 11.0105 0 0 0 0 5.00769 0 9.04606 7.63583 0 5.99177 Q96NW7 LRRC7_HUMAN Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) LRRC7 KIAA1365 LAP1 Homo sapiens (Human) "cell-cell adhesion [GO:0098609]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]" adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; postsynaptic density [GO:0014069]; specific granule lumen [GO:0035580] protein kinase binding [GO:0019901] DVPPDTITKK;HTPETEVPPSNPWQNWTR;NLPFSFTKLK;STSSHGR;VLNLSDNRLK;YGRPPYRGGLDR;YPTPYPEDLK 7 5 0.97449 -3.6667 9.41593 9.81743 0 0 0 0 10.8721 0 0 0 0 10.8722 Q96NX5 KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) CAMK1G CLICK3 VWS1 Homo sapiens (Human) signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] ASGSSHCR 1 1.7 0.9139 -0.39033 0 0 6.35327 5.9368 0 0 0 0 0 4.11728 0 0 Q96NX9 DACH2_HUMAN Dachshund homolog 2 (Dach2) DACH2 Homo sapiens (Human) development of primary female sexual characteristics [GO:0046545]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GLGAIQPGVNRCKLITR 1 2.8 0.9631 -1.0908 0 0 0 0 10.1626 0 0 7.82082 0 0 0 0 Q96NY7 CLIC6_HUMAN Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) CLIC6 CLIC1L Homo sapiens (Human) chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; D2 dopamine receptor binding [GO:0031749]; D3 dopamine receptor binding [GO:0031750]; D4 dopamine receptor binding [GO:0031751]; oxidoreductase activity [GO:0016491] FSAFIKNTKK;GPEAEARGTR 2 2.8 0.97341 -2.6359 10.4277 0 9.01033 0 0 0 0 0 0 0 0 0 Q96NY8 NECT4_HUMAN Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] NECTIN4 LNIR PRR4 PVRL4 Homo sapiens (Human) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953] adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; virus receptor activity [GO:0001618] AEGHPDSLK;NPLDGSVLLR 2 3.7 0.95299 -0.6774 0 0 10.6449 0 0 0 0 0 0 0 10.6997 0 Q96NY9 MUS81_HUMAN Crossover junction endonuclease MUS81 (EC 3.1.22.-) MUS81 Homo sapiens (Human) DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; osteoblast proliferation [GO:0033687]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429] endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657] 3'-flap endonuclease activity [GO:0048257]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] AGGSGSYWPAR;ALRSLRR;EAKILQHFGDGLCRMLDER;NLGPALSRTLSQLYCSYGPLT;WLTEWRDEATR 5 12.5 0.98013 -1.8703 13.6995 10.9864 6.99582 8.06156 0 0 0 0 0 0 0 8.77929 Q96NZ9 PRAP1_HUMAN Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein) PRAP1 UPA UNQ608/PRO1195 Homo sapiens (Human) "cellular response to X-ray [GO:0071481]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; positive regulation of intestinal lipid absorption [GO:1904731]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of triglyceride transport [GO:1905885]" endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576] triglyceride binding [GO:0017129] LLLVTSLVVVLLWEAGAVPAPK;RLLLVTSLVVVLLWEAGAVPAPK 2 15.2 0.2754 0.2547 0 0 6.79142 0 4.36737 0 0 0 0 0 0 0 Q96P16 RPR1A_HUMAN Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) RPRD1A P15RS Homo sapiens (Human) mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] QLTRMLADFLR;SVYENDVLEQLKQALYGDK;VLSIWEER 3 12.2 0.98086 -1.7303 0 0 0 0 0 7.55551 0 0 0 9.86022 0 0 Q96P20 NLRP3_HUMAN "NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)" NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; detection of biotic stimulus [GO:0009595]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type 2 immune response [GO:0002830]; protein homooligomerization [GO:0051260]; protein maturation [GO:0051604]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; interphase microtubule organizing center [GO:0031021]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; NLRP3 inflammasome complex [GO:0072559]; nucleus [GO:0005634] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; molecular sensor activity [GO:0140299]; peptidoglycan binding [GO:0042834]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein-macromolecule adaptor activity [GO:0030674]; sequence-specific DNA binding [GO:0043565]; signaling adaptor activity [GO:0035591] GYLIFVVRFLFGLVNQER;VESLSLGFLHNMPK 2 3.1 0.90472 -0.26994 5.18086 0 0 0 0 0 0 4.37907 0 0 0 0 Q96P26 5NT1B_HUMAN Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB) NT5C1B AIRP FKSG85 Homo sapiens (Human) adenosine metabolic process [GO:0046085]; purine nucleotide catabolic process [GO:0006195] cytosol [GO:0005829]; nucleus [GO:0005634] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411] ISRSPSTK;NAITIALSSCALFNMVDGR;QKKNEPGMR 3 5.9 0.9725 -2.7269 0 2.95069 0 0 0 9.38513 0 0 0 0 0 9.65397 Q96P31 FCRL3_HUMAN Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c) FCRL3 FCRH3 IFGP3 IRTA3 SPAP2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; single fertilization [GO:0007338] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; microvillus membrane [GO:0031528] kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; transmembrane signaling receptor activity [GO:0004888] DGKQLPNSYNLEK;VTVPVSRPVLTLR 2 3.5 0.97928 -1.5427 0 0 0 0 0 0 0 0 0 0 9.50476 3.41549 Q96P47 AGAP3_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)" AGAP3 CENTG3 Homo sapiens (Human) cellular response to reactive oxygen species [GO:0034614]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593] AIPIKQGILLKR;SAKDKTR;YEQKLFLAPLPSSDVPLGQQLLRAVVEDDLR 3 5.7 0.97494 -1.4352 0 5.79462 0 0 3.25375 0 0 0 10.9178 0 0 0 Q96P48 ARAP1_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)" ARAP1 CENTD2 KIAA0782 Homo sapiens (Human) actin filament organization [GO:0007015]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] "GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; type 1 angiotensin receptor binding [GO:0031702]" AGSLELR;EVRSHRPEK;GLGAGVSKVR;MTLSGSR;SVAAFTADPLSLLR;TLYIQGERR;VVEDLINHYVVVFSVDEEELR;YFDSNKDAYSK 8 7.3 0.97566 -4.355 14.3243 15.6542 13.1027 0 0 0 0 0 0 0 6.07667 9.04467 Q96P48 ARAP1_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)" ARAP1 CENTD2 KIAA0782 Homo sapiens (Human) actin filament organization [GO:0007015]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] "GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; type 1 angiotensin receptor binding [GO:0031702]" AGSLELR;AHTSPAPAPRPTPRPVPMKR;EVRSHRPEK;GLGAGVSKVR;SVAAFTADPLSLLR;TLYIQGERR;VVEDLINHYVVVFSVDEEELR;YFDSNKDAYSK 8 7 0.57849 0.18087 8.71414 0 0 0 0 0 0 0 0 0 0 0 Q96P50 ACAP3_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (Centaurin-beta-5) (Cnt-b5)" ACAP3 CENTB5 KIAA1716 Homo sapiens (Human) neuron migration [GO:0001764]; regulation of neuron projection development [GO:0010975] cytoplasm [GO:0005737]; growth cone [GO:0030426] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] FCFEVLSPTK 1 1.2 0.92363 -0.44899 0 0 0 0 0 0 0 10.7243 0 0 11.9803 0 Q96P53 WDFY2_HUMAN WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22) WDFY2 WDF2 ZFYVE22 Homo sapiens (Human) positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934] early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] metal ion binding [GO:0046872] QFAWHCSESGQR;QHHCRKCGK;VCDSCHEAITDEER 3 8.8 0.8103 0.0054361 0 0 6.68131 0 10.2198 0 0 0 8.39947 0 0 9.10001 Q96P56 CTSR2_HUMAN Cation channel sperm-associated protein 2 (CatSper2) CATSPER2 Homo sapiens (Human) calcium ion transport [GO:0006816]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] LLAQFRQIQIIILVLVR;LLAQFRQIQIIILVLVRALK;QIQIIILVLVRALK;SLKLLAQFRQIQIIILVLVR;VWPRDSLFRYFELLEK;YFELLEKLQYNLEERK 6 9.1 0.54907 0.18421 0 0 6.15423 7.34199 5.12908 0 5.50294 4.94654 10.6856 3.95438 4.76341 6.78633 Q96P63 SPB12_HUMAN Serpin B12 SERPINB12 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of protein catabolic process [GO:0042177] collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; serine-type endopeptidase inhibitor activity [GO:0004867] QKAGSLNNESGLVSCYFGQLLSK 1 5.7 0.94444 -0.6375 0 0 10.3002 7.74234 0 0 0 0 0 0 0 0 Q96P63 SPB12_HUMAN Serpin B12 SERPINB12 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of protein catabolic process [GO:0042177] collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; serine-type endopeptidase inhibitor activity [GO:0004867] VLADSSLEGQK 1 2.6 0.89375 -0.22632 0 0 12.6128 0 0 0 0 0 0 0 0 0 Q96P66 GP101_HUMAN Probable G-protein coupled receptor 101 GPR101 Homo sapiens (Human) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410] plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] EIQDMLKK 1 1.6 0.84005 -0.043952 0 0 0 0 0 0 0 0 0 8.0192 0 0 Q96P67 GPR82_HUMAN Probable G-protein coupled receptor 82 GPR82 Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DNCQQLNYLIETKNILTCLASAR 1 6.8 0.98041 -1.5734 0 0 0 0 12.528 0 0 0 0 0 0 0 Q96P70 IPO9_HUMAN Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9) IPO9 IMP9 KIAA1192 RANBP9 HSPC273 Homo sapiens (Human) proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635] histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] ELGENLDQILR;ELSQIEACQGPMQMR;VLQTIGI 3 3.2 0.95334 -0.73155 13.1827 0 0 0 9.89488 0 0 0 0 5.98507 9.79297 0 Q96P71 NECA3_HUMAN N-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51) NECAB3 APBA2BP NIP1 SYTIP2 XB51 Homo sapiens (Human) protein metabolic process [GO:0019538]; protein secretion [GO:0009306]; regulation of amyloid precursor protein biosynthetic process [GO:0042984] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; nucleus [GO:0005634] calcium ion binding [GO:0005509] LEPLREEDLAK;SDAESVEAQSRLCGSRR 2 7.1 0.89696 -0.25185 0 0 0 0 0 0 0 0 0 0 0 10.7109 Q96P88 GNRR2_HUMAN Putative gonadotropin-releasing hormone II receptor (GnRH II receptor) (GnRH-II-R) (Type II GnRH receptor) GNRHR2 Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] gonadotropin-releasing hormone receptor activity [GO:0004968] GISITSI 1 2.4 0.70114 0.16102 0 0 0 9.58885 0 9.37199 0 0 0 0 8.7366 0 Q96PB1 CASD1_HUMAN N-acetylneuraminate (7)9-O-acetyltransferase (EC 2.3.1.45) (CAS1 domain-containing protein 1) (CAS1 protein) (Cas1p) (Sialate O-acetyltransferase) (SOAT) CASD1 C7orf12 Nbla04196 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity [GO:0047186] EINHYFSVR;FYTHSSFFIPIIYILVLGVFYNENTKETKVLNR;VLALVAVLLLAACHLASRR 3 7.7 0.89753 -0.23922 0 0 0 0 0 9.6371 2.60405 0 11.4503 0 0 0 Q96PB7 NOE3_HUMAN Noelin-3 (Olfactomedin-3) (Optimedin) OLFM3 NOE3 UNQ1924/PRO4399 Homo sapiens (Human) eye photoreceptor cell development [GO:0042462]; signal transduction [GO:0007165] AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; synapse [GO:0045202] QIEDDRK;VWYMDSYTNNKIVREYK 2 5 0.95398 -0.92205 0 0 0 0 0 0 0 9.00515 0 0 0 0 Q96PB8 LRC3B_HUMAN Leucine-rich repeat-containing protein 3B (Leucine-rich repeat protein 15) LRRC3B LRP15 UNQ195/PRO221 Homo sapiens (Human) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] NAFNNLKARAR 1 4.2 0.76437 0.060815 0 0 0 0 0 0 0 0 0 0 6.81647 0 Q96PC2 IP6K3_HUMAN Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3) IP6K3 IHPK3 Homo sapiens (Human) inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; locomotion [GO:0040011]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; diphosphoinositol tetrakisphosphate kinase activity [GO:0052839]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate 6-kinase activity [GO:0000831]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" ICGMQVYQTDK;LCSEYPENK;SPKESPAK 3 6.8 0.96266 -1.1027 4.50557 0 8.59455 0 0 0 0 0 0 0 0 0 Q96PC5 MIA2_HUMAN Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) MIA2 CTAGE5 MEA11 MEA6 MGEA11 MGEA6 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; lipoprotein transport [GO:0042953]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] cargo receptor activity [GO:0038024]; enzyme activator activity [GO:0008047] EEKSKHSEQDELMADISK;FGVHRILLLAISLTK;LTVEENYR;MDGSMPSEMESSRNDTK 4 4.1 0.97826 -2.1512 0 0 0 10.4652 10.209 10.2458 9.52148 9.72098 9.46144 0 0 6.21162 Q96PD2 DCBD2_HUMAN "Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)" DCBLD2 CLCP1 ESDN Homo sapiens (Human) intracellular receptor signaling pathway [GO:0030522]; negative regulation of cell growth [GO:0030308]; wound healing [GO:0042060] cell surface [GO:0009986]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] AGWWKGMK;LKKPGPPWAAFATDEYQWLQIDLNK 2 4.3 0.9798 -2.0006 0 0 0 0 0 7.40054 0 0 0 0 0 10.9628 Q96PD4 IL17F_HUMAN Interleukin-17F (IL-17F) (Cytokine ML-1) IL17F Homo sapiens (Human) adaptive immune response [GO:0002250]; cartilage development [GO:0051216]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; negative regulation of angiogenesis [GO:0016525]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645]; regulation of interleukin-2 production [GO:0032663]; regulation of interleukin-6 production [GO:0032675]; regulation of interleukin-8 production [GO:0032677]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor binding [GO:0005126]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] LDIGIINENQR;STSPWNYTVTWDPNR;VGHTFFQKPESCPPVPGGSMK 3 28.8 0.93376 -0.51202 0 9.89115 0 0 0 3.43909 0 7.57856 0 0 0 0 Q96PD6 MOGT1_HUMAN 2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol O-acyltransferase candidate 2) (hDC2) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1) MOGAT1 DC2 DGAT2L1 Homo sapiens (Human) diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144] GVFQYNFGLMTYR;LFEEHKGK;VEFAPLNIQLARRLQTVAVLQWVLK 3 13.7 0.97592 -2.3087 0 0 0 0 0 0 0 14.895 0 0 5.10601 0 Q96PD7 DGAT2_HUMAN Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) DGAT2 HMFN1045 UNQ738/PRO1433 Homo sapiens (Human) cellular response to oleic acid [GO:0071400]; cholesterol homeostasis [GO:0042632]; diacylglycerol biosynthetic process [GO:0006651]; diacylglycerol metabolic process [GO:0046339]; fat pad development [GO:0060613]; fatty acid homeostasis [GO:0055089]; glycerol metabolic process [GO:0006071]; intracellular triglyceride homeostasis [GO:0035356]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; low-density lipoprotein particle clearance [GO:0034383]; monoacylglycerol biosynthetic process [GO:0006640]; regulation of plasma lipoprotein particle levels [GO:0097006]; triglyceride biosynthetic process [GO:0019432] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; protein homodimerization activity [GO:0042803]; retinol O-fatty-acyltransferase activity [GO:0050252] QAEADRSQR;QVIFEEGSWGRWVQK 2 6.2 0.98121 -2.029 0 0 11.9855 0 0 0 0 0 0 0 11.1394 0 Q96PE1 AGRA2_HUMAN Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) ADGRA2 GPR124 KIAA1531 TEM5 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of chemotaxis [GO:0050920]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040] cell surface [GO:0009986]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] G protein-coupled receptor activity [GO:0004930] GAPGCPLSIR;NNIISTVQPGAFLGLGELK 2 2.2 0.92951 -0.4653 0 0 0 0 0 0 8.88335 0 0 0 0 0 Q96PE2 ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) ARHGEF17 KIAA0337 TEM4 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] DGEGGHR;QEMVIEVK;QVAERINK;SLSDPIPQR 4 1.6 0.97231 -2.7631 0 0 0 0 0 11.2938 0 0 0 5.45989 0 0 Q96PE3 INP4A_HUMAN "Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)" INPP4A Homo sapiens (Human) inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038] "inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]" AKEIIAQINTLKTQVSYYAER;EVLPEDCLPR 2 3.2 0.92706 -0.45519 0 8.44601 0 11.6513 0 0 0 0 0 0 0 0 Q96PF1 TGM7_HUMAN Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7) TGM7 Homo sapiens (Human) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] MNLDFGKETQWPLLLPYSNYR 1 3 0.88798 -0.18312 0 0 0 9.76155 0 0 0 9.46113 0 0 0 0 Q96PG1 M4A4E_HUMAN Putative membrane-spanning 4-domains subfamily A member 4E MS4A4E Homo sapiens (Human) membrane [GO:0016020] KPKVLGYPYQLQQELEQQK 1 21.3 0.82369 -0.018923 0 0 0 0 0 9.90883 0 0 0 0 0 0 Q96PG2 M4A10_HUMAN Membrane-spanning 4-domains subfamily A member 10 (CD20 antigen-like 7) MS4A10 CD20L7 MS4A9 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] AEATVIPSRCAR;MKAEATVIPSR 2 5.2 0.96489 -1.1676 0 0 0 0 8.83513 0 0 0 0 0 8.57849 0 Q96PG8 BBC3B_HUMAN "Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)" BBC3 PUMA Homo sapiens (Human) apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; release of cytochrome c from mitochondria [GO:0001836] mitochondrion [GO:0005739] ATPase binding [GO:0051117] KFGMGSAQACPCQVPRAASTTWVPCQICETR 1 30.7 0.64988 0.17065 0 0 0 0 0 6.92029 0 0 0 0 0 0 Q96PJ5 FCRL4_HUMAN Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d) FCRL4 FCRH4 IFGP2 IRTA1 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] SGVGFLGDETR;VTLTCNGFQFYATEKTTWYHR 2 6.2 0.95103 -0.66653 0 0 0 0 0 0 0 0 0 0 7.15076 0 Q96PK6 RBM14_HUMAN RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) RBM14 SIP Homo sapiens (Human) "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; centriole assembly [GO:0098534]; gastrulation [GO:0007369]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centriole replication [GO:0046600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of response to DNA integrity checkpoint signaling [GO:1902151]; response to hormone [GO:0009725]; transcription initiation-coupled chromatin remodeling [GO:0045815]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription regulator complex [GO:0005667] mRNA binding [GO:0003729]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935] AAIAQLNGK;AQPSASLGVGYR;AQPSVSLGAAYR;AQPSVSLGAPYR;ASYVAPLTAQPATYR;INVELSTK;YGSDRRLAELSDYR 7 12.3 0.012146 0.85329 0 11.5836 0 0 0 0 10.3503 11.7543 0 9.65105 11.2572 6.74564 Q96PL1 SG3A2_HUMAN Secretoglobin family 3A member 2 (Pneumo secretory protein 1) (PnSP-1) (Uteroglobin-related protein 1) SCGB3A2 PNSP1 UGRP1 UNQ566/PRO1128 Homo sapiens (Human) endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615] LAPLPLDNILPFMDPLKLLLK;VPLPVDK 2 30.1 0.71304 0.14823 0 0 0 12.0846 0 12.2453 0 0 0 12.6855 12.8133 0 Q96PL2 TECTB_HUMAN Beta-tectorin TECTB Homo sapiens (Human) cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] extracellular matrix structural constituent [GO:0005201] KEAPFVLEASEIGSDLFAGVEAK 1 7 0.34302 0.23811 0 0 0 0 0 0 0 0 0 0 0 9.39889 Q96PL5 ERMAP_HUMAN Erythroid membrane-associated protein (hERMAP) (Radin blood group antigen) (Scianna blood group antigen) ERMAP RD SC Homo sapiens (Human) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] CVRLGDR 1 1.5 0.96785 -1.305 0 0 0 8.57118 0 0 0 0 0 0 0 0 Q96PM5 ZN363_HUMAN RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363 Homo sapiens (Human) error-free translesion synthesis [GO:0070987]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EVQCINCEK;QNCPICLEDIHTSR 2 8.8 0.841 -0.048714 0 0 6.49938 4.92752 0 0 0 0 0 0 0 0 Q96PM9 Z385A_HUMAN Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) ZNF385A HZF RZF ZNF385 Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; hemostasis [GO:0007599]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; platelet alpha granule organization [GO:0070889]; platelet formation [GO:0030220]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of fat cell differentiation [GO:0045600]; regulation of cytoplasmic translation [GO:2000765]" chromatin [GO:0000785]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] LLYCALCK;RLLYCALCK 2 2.3 0.92118 -0.44175 0 8.52026 0 10.5593 0 10.6627 0 0 0 0 0 0 Q96PN6 ADCYA_HUMAN Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase) ADCY10 SAC Homo sapiens (Human) cAMP biosynthetic process [GO:0006171]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; glucose catabolic process [GO:0006007]; intracellular signal transduction [GO:0035556]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of cardiac muscle cell contraction [GO:0106135]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection extension [GO:1990138]; neuron projection maintenance [GO:1990535]; neuron projection retraction [GO:0106028]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of glycogen catabolic process [GO:0045819]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of ossification [GO:0045778]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of membrane repolarization [GO:0060306]; regulation of mitophagy [GO:1901524]; spermatid development [GO:0007286] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; basal part of cell [GO:0045178]; central region of growth cone [GO:0090724]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; bicarbonate binding [GO:0071890]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] ALQMWALLQNPNR;AVKVNFLKPPPNFNFDEFFTK;ESWYSTSELK;IFPYNLISLFLHIHVEKNR;ILKLIVK;LIMGHLDLAIELGSR;QLEILFMKILKLIVK;SPEEIREK 8 6.3 0.98038 -1.5581 0 0 4.85175 0 2.81073 8.33378 0 9.34731 11.7206 10.2548 4.37927 8.7389 Q96PN7 TREF1_HUMAN Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) TRERF1 BCAR2 RAPA TREP132 Homo sapiens (Human) cellular response to progesterone stimulus [GO:0071393]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear progesterone receptor binding [GO:0033142]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714] ALATYSK;GAFGEQFDAKNKLTCSICLK;GAIPSGK;WTSLERK 4 3.4 0.98107 -1.7473 0 0 12.3549 0 0 0 0 0 0 0 9.12353 11.3004 Q96PP4 TSG13_HUMAN Testis-specific gene 13 protein TSGA13 Homo sapiens (Human) EISDAVGQSK;TLLIMTNNPPPCSITQQDK 2 10.5 0.84138 -0.051039 0 0 0 0 0 8.43854 0 0 0 0 8.25063 0 Q96PP8 GBP5_HUMAN Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) GBP5 UNQ2427/PRO4987 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein homotetramerization [GO:0051289]; protein localization to Golgi apparatus [GO:0034067]; protein targeting [GO:0006605] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; side of membrane [GO:0098552]; symbiont cell surface [GO:0106139] endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803] DVDQSFQKELETLLDAK;SKESVSHAILQTDQALTETEK;TEELKAKYYR;VQNFNLPR;VQNFNLPRLCIQKFFPK 5 11.1 0.98009 -1.5703 12.2919 0 0 0 0 0 0 0 6.47938 7.72329 6.38389 0 Q96PQ0 SORC2_HUMAN VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain] SORCS2 KIAA1329 Homo sapiens (Human) intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; neuropeptide signaling pathway [GO:0007218] cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perikaryon [GO:0043204]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038] neuropeptide receptor activity [GO:0008188] DSDFLCDYGFER;GPGPTAR;GTEPGAPGPSPGPAPGPGEDGAPAAGYR;SPPAGRAEPGGGEDR;VILVSSSLSDR;YVTCAIHNCSEK 6 7.3 0.89827 -0.23282 0 0 0 0 0 0 7.32796 10.1966 5.06785 8.56331 7.48736 0 Q96PQ1 SIG12_HUMAN Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) SIGLEC12 SIGLECL1 SLG UNQ9215/PRO34042 Homo sapiens (Human) cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691] DYLLTMQK;KGDSGKYYFQVER;LLLLLLLPPLLCGRVGAK;LLLLLLLPPLLCGRVGAKEQK;MLLLLLLLPPLLCGRVGAK;VQEDTHGR 6 8.6 0.97219 -2.8221 0 0 0 4.09085 0 5.39369 0 4.54634 9.3386 0 3.18628 9.23266 Q96PQ5 IPP2L_HUMAN "Putative protein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1, regulatory subunit 2 pseudogene 1)" PPP1R2P1 Homo sapiens (Human) glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] DLHDDDK 1 3.4 0.91084 -0.319 0 5.73666 0 0 0 0 0 6.09972 0 0 0 0 Q96PQ6 ZN317_HUMAN Zinc finger protein 317 ZNF317 KIAA1588 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFTTSASLTRHR;ECGKSFGDLVSR;HMRIHIVKKPVECR;SHTGEKPYECDHCGK 4 8.9 0.97797 -2.0629 0 0 0 0 0 5.5837 9.67869 7.96555 0 0 0 0 Q96PQ7 KLHL5_HUMAN Kelch-like protein 5 KLHL5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] YHLLPERRPMLQSPR 1 2 0.91948 -0.43769 0 0 0 0 0 0 0 0 0 0 5.7528 0 Q96PS1 FACOS_HUMAN FANCD2 opposite strand protein (Fanconi anemia group D2 protein opposite strand transcript protein) FANCD2OS C3orf24 HSD19 Homo sapiens (Human) VITAQPPK 1 4.5 0.74241 0.10231 0 0 0 0 0 0 7.48406 0 0 0 0 0 Q96PU4 UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) UHRF2 NIRF RNF107 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; protein autoubiquitination [GO:0051865]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726] heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LQYPAGYPSDK;NDPECDLCGGDPEKKCHSCSCR;NLAGNKRIGAPSADQTLTNMNR;RIGAPSADQTLTNMNR;TIDGSKTCTIEDVSR;VNELVDAR 6 9.7 0.97262 -2.5994 0 0 0 0 0 0 0 10.6082 11.1863 0 7.54048 9.95293 Q96PU5 NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) NEDD4L KIAA0439 NEDL3 Homo sapiens (Human) cell differentiation [GO:0030154]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion import across plasma membrane [GO:1903783]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendrite extension [GO:1903861]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of protein stability [GO:0031647]; regulation of sodium ion transmembrane transport [GO:1902305]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular cardiac muscle cell action potential [GO:0086005] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654] potassium channel inhibitor activity [GO:0019870]; potassium channel regulator activity [GO:0015459]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LLQFVTGTSR;VTQSFLPPGWEMR 2 2.4 0.78653 0.017309 0 0 0 0 0 0 0 0 5.59953 0 0 0 Q96PU9 CMA1A_HUMAN Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3) (Sperm tail protein SHIPPO 1) (Transcript induced in spermiogenesis protein 50) CIMAP1A ODF3 SHIPPO1 TISP50 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer dense fiber [GO:0001520] GPIMALYSSPGPK;VEPPGDK 2 7.9 0.90166 -0.26376 0 0 0 0 0 8.81304 0 10.0745 0 0 0 0 Q96PV0 SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) SYNGAP1 KIAA1938 Homo sapiens (Human) axonogenesis [GO:0007409]; dendrite development [GO:0016358]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of axonogenesis [GO:0050771]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Ras protein signal transduction [GO:0046580]; neuron apoptotic process [GO:0051402]; pattern specification process [GO:0007389]; Ras protein signal transduction [GO:0007265]; receptor clustering [GO:0043113]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of MAPK cascade [GO:0043408]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic plasticity [GO:0048167]; visual learning [GO:0008542] cytosol [GO:0005829]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] AIEEYMR;AKDFLSDMAMSEVDR;ASIHRGSIPAMSYAPFR;DSQIKSIIGRLMLVEEELR;EFAEYVTNHYR;GKGGCPAVR;SSPAYCTSSSDITEPEQKMLSVNK 7 7.6 0.97407 -2.9956 10.1338 0 8.63757 7.08215 0 9.32024 0 7.26763 10.0204 0 0 10.3337 Q96PV4 PNMA5_HUMAN Paraneoplastic antigen-like protein 5 (Tumor antigen BJ-HCC-25) PNMA5 KIAA1934 Homo sapiens (Human) positive regulation of apoptotic process [GO:0043065] identical protein binding [GO:0042802] AGLQPLCAYR 1 2.2 0.80454 0.01313 0 0 0 0 0 0 0 0 0 0 5.83481 0 Q96PV6 LENG8_HUMAN Leukocyte receptor cluster member 8 LENG8 KIAA1932 Homo sapiens (Human) nucleus [GO:0005634]; protein-containing complex [GO:0032991] CFTACESEEDK;GAGSATR;GQQLWNR;SIRQDLTVQGIR 4 4.6 0.93796 -0.56941 0 0 0 0 0 0 6.54147 9.8363 0 0 12.8063 0 Q96PV7 F193B_HUMAN Protein FAM193B FAM193B IRIZIO KIAA1931 Homo sapiens (Human) cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DPGCKGHK 1 0.9 0.39568 0.2116 0 0 0 0 0 0 0 0 9.78733 0 0 0 Q96PX6 CC85A_HUMAN Coiled-coil domain-containing protein 85A CCDC85A KIAA1912 Homo sapiens (Human) adherens junction [GO:0005912] MLPQASQNRRQPPTR 1 2.7 0.959 -1.0365 0 0 0 0 0 0 0 0 0 0 0 12.3327 Q96PX9 PKH4B_HUMAN Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B) PLEKHG4B KIAA1909 Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; regulation of small GTPase mediated signal transduction [GO:0051056] basal plasma membrane [GO:0009925]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ELERCQHCPLAVGR;ESAFRPDK;GKHHVIFGNLEK;NKPQSDALLSSHGNAFFK 4 3.2 0.9781 -1.9476 0 5.93071 0 7.83352 0 0 0 0 0 0 11.5289 0 Q96PY5 FMNL2_HUMAN Formin-like protein 2 (Formin homology 2 domain-containing protein 2) FMNL2 FHOD2 KIAA1902 Homo sapiens (Human) cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267] EVCGEKQR;EVCGEKQRFEK;IAQDAFDDVVKYFGENPK;KPLENLSDEDRFMMQFSK;KQTLLHYISNVVKEK;QSTLEKK;QYDNEKKWELICDQER 7 7.8 0.97642 -2.2685 0 13.0229 13.0895 11.468 0 11.1659 0 0 4.7512 10.8839 8.68626 8.35826 Q96PY6 NEK1_HUMAN Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) NEK1 KIAA1901 Homo sapiens (Human) cell division [GO:0051301]; cilium assembly [GO:0060271]; protein phosphorylation [GO:0006468] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AEDNEAK;AKQVEEFLQR;AREQGWRNVLSAGGSGEVK;GQLAVERAK;LEFIEKEK;LQKIGEGSFGKAILVK 6 5.3 0.97478 -2.4006 7.93021 0 0 0 0 0 0 10.0146 0 0 7.53877 8.74903 Q96PZ0 PUS7_HUMAN Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 KIAA1897 Homo sapiens (Human) mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; negative regulation of translation [GO:0017148]; pseudouridine synthesis [GO:0001522]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mesoderm development [GO:2000380]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119] nucleus [GO:0005634] enzyme binding [GO:0019899]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine(13) synthase activity [GO:0160150] GALVVEDNDSGVPVEETKKQK;GGKNSEAQLEDEEEEEEDGLSEECEEEESESFADMMK;VKPNIFSYMGTKDK;YLRVKPNIFSYMGTK 4 11.3 0.97645 -2.1976 0 0 0 0 0 0 10.7367 0 0 0 0 0 Q96PZ2 F111A_HUMAN Serine protease FAM111A (EC 3.4.21.-) FAM111A KIAA1895 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; replication fork processing [GO:0031297] chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697] EIETHQGQEMLVR;GDPRATTNTQAQR;IEHYFSPVSK;KEIETHQGQEMLVRGTEGIK;YFQVEVEK 5 8.3 0.97303 -2.5815 7.8219 0 9.07337 0 0 0 0 11.2426 0 0 0 11.3144 Q96PZ7 CSMD1_HUMAN CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) conditioned place preference [GO:1990708]; female gonad development [GO:0008585]; glucose homeostasis [GO:0042593]; male gonad development [GO:0008584]; mammary gland branching involved in pregnancy [GO:0060745]; memory [GO:0007613]; oviduct epithelium development [GO:0035846]; startle response [GO:0001964] membrane [GO:0016020] AVRFDTTLNTVCTVV;AVYQEIEK;FQSLLLLLGLLVLCARLLTAAK;ITCVQLNNR;LTCLGGGR;TCGSNLR;TPVPSDVFFVNSLWKGYYEYLGK 7 2.6 0.97627 -2.2876 0 6.36228 0 0 0 0 0 12.1032 12.3151 10.9856 0 9.66786 Q96Q04 LMTK3_HUMAN Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3) LMTK3 KIAA1883 TYKLM3 Homo sapiens (Human) axon [GO:0030424]; dendrite [GO:0030425]; Golgi membrane [GO:0000139] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGGDTALSGDGDPPKPERKGPEMPR;FISEAQPYR;VLENGELTPPRR 3 3.2 0.91006 -0.28972 0 0 0 0 0 10.8792 0 11.0288 8.18785 0 0 0 Q96Q05 TPPC9_HUMAN Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein) TRAPPC9 KIAA1882 NIBP T1 Homo sapiens (Human) cerebral cortex development [GO:0021987]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neuron differentiation [GO:0030182]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] DFVGLDTDSR;DPQWASAGPPPLSFTEEVK;ICSVSQISVRDSQRVLYIR;LEETLAQFPLQPGK;LLHELVYASR;LLNLPASLRPHKMKSLLGQNVSTK;NAGVIELEACIKAVRVLAIQK 7 9.4 0.97437 -1.3795 9.90647 0 10.481 8.05077 2.69735 0 0 11.3175 0 0 0 11.6813 Q96Q06 PLIN4_HUMAN Perilipin-4 (Adipocyte protein S3-12) PLIN4 KIAA1881 Homo sapiens (Human) cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] LGDLGPSFRQR;LGDLGPSFRQRAFEHAVSHLQHGQFQAR 2 2 0.82507 -0.020943 0 0 0 0 0 0 10.4644 0 0 0 0 10.9403 Q96Q07 BTBD9_HUMAN BTB/POZ domain-containing protein 9 BTBD9 KIAA1880 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; circadian sleep/wake cycle, non-REM sleep [GO:0042748]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of synaptic vesicle endocytosis [GO:1900242]; sensory perception of temperature stimulus [GO:0050951]; serotonin metabolic process [GO:0042428]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978] APSGSSLPSSPGSNSR;LTCMCCMFMDR;LYFPARVCR;VSCKSWQSVTFERQPASFIR 4 9.2 0.97973 -1.8562 0 0 0 0 0 0 0 12.9927 0 0 10.8561 10.1361 Q96Q11 TRNT1_HUMAN "CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)" TRNT1 CGI-47 Homo sapiens (Human) mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA surveillance [GO:0106354] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] DELLSYIKKT;EIGALLQQLREQWK;GLAGISGER 3 7.6 0.98021 -1.8067 0 0 0 0 0 4.74642 0 0 8.66181 0 0 0 Q96Q15 SMG1_HUMAN Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) SMG1 ATX KIAA0421 LIP Homo sapiens (Human) "DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of telomere maintenance [GO:0032204]" chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] AEYAVAK;AVQERNSYAVSVWK;EFFRLCGTFSK;EIMLSLQQR;KHFSIILNLLGILLKK;LLRLLVKHAGELR;LSCEQVLHIMR;LSSGGGGGGTKYPR;LSTQGQVDEK;SMSYSDESR;VSVDDLCK;YAADINSR 12 3.6 0.97466 -3.4882 8.64267 11.317 11.9238 11.0173 9.00388 0 9.90898 7.60622 6.57513 0 0 0 Q96Q27 ASB2_HUMAN Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell differentiation [GO:0055007]; dendritic cell migration [GO:0036336]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; podosome assembly [GO:0071800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle cell differentiation [GO:0035914]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; stress fiber [GO:0001725]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018] cullin family protein binding [GO:0097602] LLDTLPLPGRLIR 1 2 0.92419 -0.44875 0 0 0 0 0 0 0 8.38858 0 0 0 0 Q96Q35 FACC1_HUMAN Flagellum-associated coiled-coil domain-containing protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein) FLACC1 ALS2CR12 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126] FERENILLQQK;YLKNMFR 2 4 0.97082 -1.345 0 0 0 0 0 0 0 0 0 7.94708 0 0 Q96Q40 CDK15_HUMAN Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) CDK15 ALS2CR7 PFTK2 Homo sapiens (Human) regulation of cell cycle phase transition [GO:1901987] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] LADFGLAR;SNSDCFQEEDLR 2 4.6 0.81 0.0092647 0 0 0 0 0 3.98067 0 0 0 0 0 0 Q96Q42 ALS2_HUMAN Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) "behavioral fear response [GO:0001662]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; locomotory behavior [GO:0007626]; lysosomal transport [GO:0007041]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; vesicle [GO:0031982] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; small GTPase binding [GO:0031267] AGYGVFDDITR;AMNKEDHYVGHWK;DATYDGR;LLRKAAR;LSLPGLLSQVSPRLLRK;NIPSYPDTQAVNEYLRK;VTAGKDSYLALVDK;WLRAISQAVDQALR 8 5.8 0.98006 -1.8705 0 12.6113 0 0 0 10.2091 11.2518 7.33646 11.0919 12.3153 6.24306 0 Q96Q80 DERL3_HUMAN Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3) DERL3 C22orf14 DER3 LLN2 Homo sapiens (Human) "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]" endoplasmic reticulum membrane [GO:0005789] protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047] AYTAACVLTTAAVQLELLSPFQLYFNPHLVFRK 1 16.1 0.64904 0.17097 10.326 0 0 0 0 0 0 0 0 0 0 0 Q96Q83 ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) ALKBH3 ABH3 DEPC1 Homo sapiens (Human) cell population proliferation [GO:0008283]; DNA alkylation repair [GO:0006307]; DNA repair [GO:0006281]; negative regulation of cytoplasmic translation [GO:2000766] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; mRNA N1-methyladenosine dioxygenase activity [GO:1990930]; oxidative RNA demethylase activity [GO:0035515] NRIEENTGHTFNSLLCNLYRNEK 1 8 0.86538 -0.091958 0 0 0 0 0 0 0 7.0648 0 0 0 0 Q96Q89 KI20B_HUMAN Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) KIF20B KRMP1 MPHOSPH1 Homo sapiens (Human) cell division [GO:0051301]; microtubule-based movement [GO:0007018]; neural tube closure [GO:0001843]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron migration [GO:2001224]; protein localization to microtubule [GO:0035372]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic nuclear division [GO:0007088] centrosome [GO:0005813]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein homodimerization activity [GO:0042803]; WW domain binding [GO:0050699] ALISSNVQKDNEIEQLK;DLVGKCDTR;EEEEETNRQETEKLK;EEVTQEFTQYWAQREADFK;ESIILKLERNLK;EYLRLSSEQEK;KWLEEKMMLITQAK;LSEKSSGQMAQKFSFSK;LSNEIETATR;LSNVEASK;SNEMEEDLVKCENK 11 8 0.95433 -0.90283 0 4.70747 0 0 0 0 0 0 0 0 0 0 Q96Q89 KI20B_HUMAN Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) KIF20B KRMP1 MPHOSPH1 Homo sapiens (Human) cell division [GO:0051301]; microtubule-based movement [GO:0007018]; neural tube closure [GO:0001843]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron migration [GO:2001224]; protein localization to microtubule [GO:0035372]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic nuclear division [GO:0007088] centrosome [GO:0005813]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein homodimerization activity [GO:0042803]; WW domain binding [GO:0050699] ALISSNVQKDNEIEQLK;DLVGKCDTR;EEEEETNRQETEKLK;EEVTQEFTQYWAQREADFK;ESIILKLERNLK;EYLRLSSEQEK;GKEVENFEK;GKEVENFEKNLD;KWLEEKMMLITQAK;LSEKSSGQMAQKFSFSK;LSNEIETATR 11 7.9 0.97474 -3.2422 0 0 0 11.3055 7.99498 10.8765 0 13.5926 0 8.64353 6.26172 0 Q96Q91 B3A4_HUMAN Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Sodium bicarbonate cotransporter 5) (Solute carrier family 4 member 9) SLC4A9 AE4 SBC5 Homo sapiens (Human) bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; saliva secretion [GO:0046541]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] "chloride:bicarbonate antiporter activity [GO:0140900]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]" STPAAIIFPLMLLGLVGVRKALER;VKLLLMPAKHQPDLLLLR 2 4.3 0.12884 0.35714 0 0 5.06518 0 5.95589 0 0 0 0 0 0 0 Q96QA5 GSDMA_HUMAN "Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]" GSDMA GSDM GSDM1 FKSG9 Homo sapiens (Human) defense response to bacterium [GO:0042742]; programmed cell death [GO:0012501]; pyroptotic inflammatory response [GO:0070269] cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]" KLAADHPFLK 1 2.2 0.91677 -0.36145 0 0 12.0259 0 0 6.17528 0 0 0 0 0 0 Q96QA6 YPEL2_HUMAN Protein yippee-like 2 YPEL2 FKSG4 Homo sapiens (Human) nucleolus [GO:0005730] metal ion binding [GO:0046872] MTRSKTFQAYLPSCHR;YEHAFESSQKYKEGK;YIIELAHMIKDNGWD 3 38.7 0.97843 -1.982 0 0 0 0 9.55777 0 0 0 0 5.97721 0 0 Q96QB1 RHG07_HUMAN Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) DLC1 ARHGAP7 KIAA1723 STARD12 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain morphogenesis [GO:0021575]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of execution phase of apoptosis [GO:1900119]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; SH2 domain binding [GO:0042169] IVNQWSEK;LFQVPEEMSR;MESLKLKSSHHSK;SLSACNK;TAKSKTR 5 2.9 0.9519 -0.68426 0 0 10.3662 7.0691 0 0 7.35966 0 0 0 0 0 Q96QC0 PP1RA_HUMAN Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99) PPP1R10 CAT53 FB19 PNUTS Homo sapiens (Human) negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206]; protein import into nucleus [GO:0006606] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723] HFMMKGNCR;TTLPERPLTEVK;TTNNIPLLQQILLTLQHLPLTVDHLK;VPWVCPRPLVLPSPLVTPGSNSQERYIQAER;YIQAEREK 5 8.5 0.97476 -3.0939 0 0 0 11.2541 0 9.84712 0 0 0 9.98328 9.98142 0 Q96QD5 DEPD7_HUMAN DEP domain-containing protein 7 (Protein TR2/D15) DEPDC7 Homo sapiens (Human) intracellular signal transduction [GO:0035556] FTTIPNQDSQLGK;IDQRDYSNNTEK;LLDFQNR;LYSPARYADALFK 4 8.8 0.97242 -2.7555 10.3113 10.7057 0 0 0 0 0 0 0 0 0 8.59913 Q96QD9 UIF_HUMAN UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) FYTTD1 UIF Homo sapiens (Human) mRNA export from nucleus [GO:0006406] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729]; RNA binding [GO:0003723] GVPLQFDINSVGK;RPNGVITGLAARKTTGIR 2 9.7 0.41317 0.2033 0 0 0 0 0 6.59154 9.3614 0 0 0 0 0 Q96QE2 MYCT_HUMAN Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020] SLSSLMGERRR;YSYCNECMLDPDCGFCYK 2 4.5 0.75573 0.074558 0 0 0 7.06091 0 3.35769 0 0 0 0 0 0 Q96QE3 ATAD5_HUMAN ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) ATAD5 C17orf41 Elg1 FRAG1 Homo sapiens (Human) cell population proliferation [GO:0008283]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; nuclear DNA replication [GO:0033260]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of DNA replication [GO:0045740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990]; signal transduction in response to DNA damage [GO:0042770] Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp unloader activity [GO:0061860] AELEERQNLK;ALETLNSCKKLGR;DFLMSGLPDLLK;DSGTEDMLWTEK;ETVNTLAADFP;FLHYFEGIHLDIPK;HEDFSGGIDFKGSSDDEEESR;KASNTSK;RNNSSGIK;RRFLHYFEGIHLDIPK;SLLYVGNR;VPPPSPKSSGPK 12 7 0.97643 -4.988 10.1983 0 8.40723 0 0 0 0 12.7024 0 9.33318 10.9905 0 Q96QE5 TEFM_HUMAN "Transcription elongation factor, mitochondrial" TEFM C17orf42 Homo sapiens (Human) mitochondrial transcription [GO:0006390]; oxidative phosphorylation [GO:0006119]; transcription elongation by mitochondrial RNA polymerase [GO:0006392] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904] DNA polymerase processivity factor activity [GO:0030337]; RNA binding [GO:0003723] VFFPSDK 1 1.9 0.56418 0.18271 0 0 0 7.7366 7.89403 6.59886 0 7.99611 8.85009 0 0 0 Q96QF0 RAB3I_HUMAN Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) RAB3IP RABIN8 Homo sapiens (Human) ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of filopodium assembly [GO:0051490]; positive regulation of cilium assembly [GO:0045724]; protein localization to motile cilium [GO:0120229]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proximal dendrite [GO:1990635]; trans-Golgi network membrane [GO:0032588] GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802] IDVLQAEVAALK;TPFKKGHTR;YRITSVCNFFTYIR 3 7.4 0.9765 -2.2455 0 0 0 0 0 0 0 0 11.127 0 0 0 Q96QF7 GCNA_HUMAN Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear acidic peptidase) (Germ cell nuclear antigen) GCNA ACRC Homo sapiens (Human) protein-DNA covalent cross-linking repair [GO:0106300] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] SUMO polymer binding [GO:0032184] RQASCILNVQSR;SLDTSRFICAK;VTRCHNYK 3 4.5 0.95443 -0.9027 0 0 0 0 7.98556 0 9.16408 0 0 0 9.55591 0 Q96QH2 PRAM_HUMAN PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1) PRAM1 Homo sapiens (Human) integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; regulation of neutrophil degranulation [GO:0043313]; T cell receptor signaling pathway [GO:0050852] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] lipid binding [GO:0008289]; protein kinase binding [GO:0019901] EKDPQPQQLPPMDPK;FKFEGEIVVHTK;SGAFPRK;SGAFPRKLWQPEAGEATPR 4 6.9 0.97456 -2.3918 0 0 0 0 0 7.68832 9.07585 0 12.1978 0 0 0 Q96QI5 HS3S6_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6) (3-OST-6) (Heparan sulfate 3-O-sulfotransferase 6) (h3-OST-6) HS3ST6 HS3ST5 Homo sapiens (Human) "blastocyst hatching [GO:0001835]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] RLQEFYRPFNR;TLDGQITMEK 2 6.1 0.88241 -0.17619 0 0 0 0 9.4614 0 0 0 0 0 0 0 Q96QK1 VPS35_HUMAN Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) VPS35 MEM3 TCCCTA00141 Homo sapiens (Human) "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of protein localization [GO:1903828]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of postsynapse assembly [GO:0150052]; regulation of presynapse assembly [GO:1905606]; regulation of protein metabolic process [GO:0051246]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055]" "cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]" D1 dopamine receptor binding [GO:0031748] AELAELPLR;ESPESEGPIYEGLIL;GVQHPLRGLFLR;IPVDTYNNILTVLK;LSQLEGVNVER;SEDPDQQYLILNTAR 6 9.5 0 4.7918 0 10.8865 0 8.81465 7.90479 8.45644 9.97571 9.70307 0 9.85814 9.80784 9.69935 Q96QP1 ALPK1_HUMAN Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase) ALPK1 KIAA1527 LAK Homo sapiens (Human) cilium assembly [GO:0060271]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; monosaccharide binding [GO:0048029]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EMKWPFVPEK;GGRRNWTHSDAFR;ISVNSGK;LLQVAKGLHK;LLQVAKGLHKLQPATPIAPQVVIR;VVAVLLQECK 6 5.1 0.96584 -1.259 13.5578 13.7389 13.9044 11.256 0 9.74485 11.0153 9.4599 11.1862 0 8.6647 4.41434 Q96QR8 PURB_HUMAN Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) PURB Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]" KYYLDLKENQR;LDIQNKRFYLDVK 2 7.7 0.95481 -0.97539 0 11.7901 0 0 0 0 0 0 0 0 0 0 Q96QS1 TSN32_HUMAN Tetraspanin-32 (Tspan-32) (Protein Phemx) TSPAN32 PHEMX TSSC6 Homo sapiens (Human) cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; defense response to protozoan [GO:0042832]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of myeloid dendritic cell activation [GO:0030886]; negative regulation of T cell proliferation [GO:0042130]; platelet aggregation [GO:0070527]; regulation of defense response to virus [GO:0050688]; T cell proliferation [GO:0042098] cell surface [GO:0009986]; integrin alphaIIb-beta3 complex [GO:0070442]; plasma membrane [GO:0005886] QELAAIQDVFLCCGK;QELAAIQDVFLCCGKK 2 5 0.83906 -0.039352 0 0 0 0 0 7.59999 0 0 0 0 10.3919 0 Q96QS3 ARX_HUMAN Homeobox protein ARX (Aristaless-related homeobox) ARX Homo sapiens (Human) axon guidance [GO:0007411]; cell proliferation in forebrain [GO:0021846]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex tangential migration [GO:0021800]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; epithelial cell fate commitment [GO:0072148]; globus pallidus development [GO:0021759]; lipid digestion [GO:0044241]; negative regulation of transcription by RNA polymerase II [GO:0000122]; organ growth [GO:0035265]; positive regulation of gene expression [GO:0010628]; positive regulation of organ growth [GO:0046622]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LDLTEARVQVWFQNR 1 2.7 0.91582 -0.43376 0 0 0 0 0 0 6.94848 0 0 0 0 0 Q96QS6 PSKH2_HUMAN Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) PSKH2 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASPHSQSPGSAQSSK;LIAQGSFTER;NLKPENLLYYHPGEESK;VEQKTTKKPFAIK 4 14.3 0.95495 -0.83514 0 0 0 6.75235 0 0 0 0 0 0 0 7.68888 Q96QT4 TRPM7_HUMAN "Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]" TRPM7 CHAK1 LTRPC7 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-matrix adhesion [GO:0016340]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; monoatomic cation homeostasis [GO:0055080]; monoatomic cation transmembrane transport [GO:0098655]; necroptotic process [GO:0070266]; protein autophosphorylation [GO:0046777]; protein homotetramerization [GO:0051289]; protein phosphorylation [GO:0006468]; zinc ion transport [GO:0006829] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion transmembrane transporter activity [GO:0015095]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion transmembrane transporter activity [GO:0005385] AKYVRLSYDTKPEVILQLLLK;DVVAPYQTLLNPLSK;ILDSNEGK;LHGVELLKIFNKNQK;NTSSSTPQLR;TLTAQKASEASK;VILSILVPPAILLLEYK 7 5.3 0.9805 -1.5987 10.1961 7.97241 0 0 8.6561 0 0 10.6561 13.0363 7.90442 0 0 Q96QT6 PHF12_HUMAN PHD finger protein 12 (PHD factor 1) (Pf1) PHF12 KIAA1523 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] AIAHARILER;QMPSHWDSEQTEK 2 2.3 0.9805 -1.6118 0 0 0 0 7.94626 13.214 0 0 0 0 0 0 Q96QU1 PCD15_HUMAN Protocadherin-15 PCDH15 USH1F Homo sapiens (Human) cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] extracellular region [GO:0005576]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; synapse [GO:0045202] calcium ion binding [GO:0005509] GILRHVKNLAELEK;IEDLTEILDR;LIIPPIKEGK;NSICTVYIEVLPPNNQSPPR;SYFKFQVIATDDYGK 5 3.5 0.97834 -2.0774 8.51207 0 8.34376 0 0 3.51248 0 10.7679 0 0 0 8.82918 Q96QU6 1A1L1_HUMAN 1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACC synthase-like protein 1) ACCS PHACS Homo sapiens (Human) amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GAGFFIWVDLRK;LDQKLPELR 2 4.2 0.96417 -1.1657 0 13.1148 13.3358 0 0 8.53749 0 0 0 0 0 0 Q96QU8 XPO6_HUMAN Exportin-6 (Exp6) (Ran-binding protein 20) XPO6 KIAA0370 RANBP20 Homo sapiens (Human) protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] FCLYFLSSTRNDYVMMYSLTVFENLINK;LVNDLRYYR;TLHHNWRYFFK;TLPYFIRNKLCK 4 5.3 0.97414 -2.4599 0 0 0 0 10.784 0 0 0 0 0 0 9.19778 Q96QV1 HHIP_HUMAN Hedgehog-interacting protein (HHIP) (HIP) HHIP HIP UNQ5825/PRO19644 Homo sapiens (Human) dorsal/ventral pattern formation [GO:0009953]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; negative regulation of smoothened signaling pathway [GO:0045879]; neuroblast proliferation [GO:0007405]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705] cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] hedgehog family protein binding [GO:0097108]; zinc ion binding [GO:0008270] CCCSPGWEGDFCR;GYLGPQCEQVDRNIRR;LYVSYTTNQER 3 5.7 0.7321 0.1167 0 0 0 7.7324 0 0 0 0 8.90521 4.49665 0 0 Q96QZ0 PANX3_HUMAN Pannexin-3 PANX3 Homo sapiens (Human) cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; osteoblast differentiation [GO:0001649]; positive regulation of interleukin-1 production [GO:0032732] endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; gap junction hemi-channel activity [GO:0055077]; structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829] SSDPYVFWNELEKAR;SYNRSIRLVQHMLK;YLACKQR 3 9.2 0.9534 -0.7832 0 0 0 0 0 0 0 11.12 0 0 9.64268 0 Q96QZ7 MAGI1_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)" MAGI1 AIP3 BAIAP1 BAP1 TNRC19 Homo sapiens (Human) cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; positive regulation of cell-cell adhesion [GO:0022409]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] alpha-actinin binding [GO:0051393]; ATP binding [GO:0005524] AHARDPK;KNVQALTHNQVVDMLVECPK;KPDSGACRPKDRAPEGR;LAEDGPAER;LLEQRRSPER;NMKHSRAIELIK;RRPYKECSTDLSI;SHSDIVNLIK;VGDRILAVNGCSITNK 9 7.6 0.97748 -5.847 12.1711 0 0 11.1372 11.3781 0 8.54859 10.397 0 10.269 7.90767 11.2175 Q96R05 RET7_HUMAN Retinoid-binding protein 7 (Cellular retinoic acid-binding protein 4) (CRABP4) (CRBP4) (Cellular retinoic acid-binding protein IV) (CRABP-IV) RBP7 Homo sapiens (Human) fatty acid transport [GO:0015908] cytosol [GO:0005829]; nucleus [GO:0005634] fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinol binding [GO:0019841] PADLSGTWTLLSSDNFEGYMLALGIDFATRK 1 23.1 0.37001 0.2273 0 12.5015 0 0 0 0 0 0 0 0 0 0 Q96R06 SPAG5_HUMAN Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) SPAG5 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of spindle orientation [GO:0051294]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of metaphase plate congression [GO:0090235]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604] microtubule binding [GO:0008017] AQLQILANMDSQLKELQSQHTHCAQDLAMK 1 2.5 0.84169 -0.045328 0 0 0 0 0 0 0 0 6.92766 0 0 0 Q96R28 OR2M2_HUMAN Olfactory receptor 2M2 (OST423) OR2M2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SESELPHKLYVLLFAKFFFLISIFFYDVK 1 8.4 0.8736 -0.11366 0 0 11.0731 0 0 0 0 0 0 0 0 0 Q96R72 OR4K3_HUMAN Olfactory receptor 4K3 (Olfactory receptor OR14-14) OR4K3 OR4K3P Homo sapiens (Human) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SSGGSSK 1 2.2 0.70969 0.15802 8.92944 0 9.99676 0 0 0 0 0 0 0 10.2299 0 Q96R84 OR1F2_HUMAN Putative olfactory receptor 1F2 (OLFmf2) OR1F2P OR1F2 Homo sapiens (Human) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FVAVCRPLHYTAK 1 4.2 0.89698 -0.23596 0 0 0 0 0 0 0 0 0 11.4082 0 0 Q96RA2 OR7D2_HUMAN Olfactory receptor 7D2 (HTPCRH03) (Olfactory receptor 19-4) (OR19-4) (Olfactory receptor OR19-10) OR7D2 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MSSSGGK 1 2.2 0.68501 0.1639 0 0 0 0 0 0 0 0 0 8.045 0 0 Q96RD6 PANX2_HUMAN Pannexin-2 PANX2 Homo sapiens (Human) cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732]; response to ischemia [GO:0002931] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829] EIIENAEKEKSPEQNLFEK;IEKQIQSK 2 4 0.96606 -1.126 10.2027 0 0 0 0 0 0 0 0 0 0 0 Q96RD7 PANX1_HUMAN Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] PANX1 MRS1 UNQ2529/PRO6028 Homo sapiens (Human) ATP transport [GO:0015867]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic cation transport [GO:0006812]; oogenesis [GO:0048477]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage cytokine production [GO:0060907]; response to ATP [GO:0033198]; response to ischemia [GO:0002931] bleb [GO:0032059]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] actin filament binding [GO:0051015]; ATP transmembrane transporter activity [GO:0005347]; calcium channel activity [GO:0005262]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; leak channel activity [GO:0022840]; monoatomic anion channel activity [GO:0005253]; protease binding [GO:0002020]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; wide pore channel activity [GO:0022829] FIMEELDKVYNR;FIMEELDKVYNRAIK 2 3.5 0.98181 -1.5826 0 0 0 0 0 0 11.9318 4.79317 0 0 4.89971 0 Q96RE7 NACC1_HUMAN Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) NACC1 BTBD14B NAC1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357] cell junction [GO:0030054]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LQGLYCDVSVVVK;YYCQNFAPNFK 2 4.6 0.91592 -0.37588 0 0 14.4077 0 0 0 0 0 4.41353 0 0 0 Q96RE9 ZN300_HUMAN Zinc finger protein 300 ZNF300 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" IHTGEKPYKCAQCEEAFSR 1 3.1 0.9192 -0.43801 5.22338 0 0 0 0 0 0 0 0 0 0 0 Q96RG2 PASK_HUMAN PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) PASK KIAA0135 Homo sapiens (Human) energy homeostasis [GO:0097009]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LSIQFEVR 1 0.6 0.91492 -0.39033 0 0 0 0 0 0 10.4671 0 0 0 0 0 Q96RI1 NR1H4_HUMAN Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) NR1H4 BAR FXR HRR1 RIP14 Homo sapiens (Human) bile acid metabolic process [GO:0008206]; cell differentiation [GO:0030154]; cell-cell junction assembly [GO:0007043]; cellular response to bile acid [GO:1903413]; cellular response to fatty acid [GO:0071398]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; defense response to bacterium [GO:0042742]; fatty acid homeostasis [GO:0055089]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; Notch signaling pathway [GO:0007219]; nuclear receptor-mediated bile acid signaling pathway [GO:0038185]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of ammonia assimilation cycle [GO:2001250]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glutamate metabolic process [GO:2000213]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of phosphatidic acid biosynthetic process [GO:1905695]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of cholesterol metabolic process [GO:0090181]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of urea metabolic process [GO:0034255]; toll-like receptor 9 signaling pathway [GO:0034162]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "bile acid binding [GO:0032052]; bile acid nuclear receptor activity [GO:0038186]; chenodeoxycholic acid binding [GO:1902122]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" GLLTEIQCK;QRMPQEITNK 2 4.5 0.95523 -0.97888 0 0 0 0 0 0 0 0 0 4.95061 0 0 Q96RI8 TAAR6_HUMAN Trace amine-associated receptor 6 (TaR-6) (Trace amine receptor 6) (Trace amine receptor 4) (TaR-4) TAAR6 TA4 TAR4 TRAR4 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] TESSSESYKAR 1 3.2 0.92182 -0.44293 0 0 0 0 0 3.91829 0 0 0 0 0 0 Q96RJ3 TR13C_HUMAN Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268) TNFRSF13C BAFFR BR3 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell costimulation [GO:0031296]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] TAGPEQQ 1 3.8 0.7099 0.15645 0 0 0 0 0 0 0 0 7.502 0 0 0 Q96RJ6 FER3L_HUMAN Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) FERD3L BHLHA31 NATO3 NTWIST Homo sapiens (Human) cell development [GO:0048468]; developmental process [GO:0032502]; floor plate development [GO:0033504]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" RMFNLNEAFDQLR 1 7.8 0.66628 0.1685 0 0 0 0 0 0 0 0 0 8.28526 0 0 Q96RK0 CIC_HUMAN Protein capicua homolog CIC KIAA0306 Homo sapiens (Human) brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; social behavior [GO:0035176] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SQRVLARR;TPLTAAQQK 2 0.7 0.97998 -1.6543 0 0 0 0 0 0 0 0 0 12.0733 0 0 Q96RK4 BBS4_HUMAN BBSome complex member BBS4 (Bardet-Biedl syndrome 4 protein) BBS4 Homo sapiens (Human) adult behavior [GO:0030534]; B cell homeostasis [GO:0001782]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; erythrocyte homeostasis [GO:0034101]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of systemic arterial blood pressure [GO:0003085]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to organelle [GO:0033365]; protein localization to photoreceptor outer segment [GO:1903546]; protein transport [GO:0015031]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; regulation of non-motile cilium assembly [GO:1902855]; regulation of stress fiber assembly [GO:0051492]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; social behavior [GO:0035176]; sperm flagellum assembly [GO:0120316]; spermatid development [GO:0007286]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] APEFPILEK 1 1.7 0.9303 -0.4789 0 0 0 0 0 0 0 0 0 0 0 11.5514 Q96RL1 UIMC1_HUMAN BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) UIMC1 RAP80 RXRIP110 Homo sapiens (Human) DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; ubiquitin-modified histone reader activity [GO:0061649] ADQGDGPEGSGR;DLNESPVK;EKGHSEGRLLSFLEQSEHK;NECISEDMGDEDK;QSNRAKCLAK 5 8.6 0.97601 -1.4649 6.15696 4.50932 0 9.56626 0 0 0 0 0 6.38636 12.6788 0 Q96RL7 VP13A_HUMAN Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) VPS13A CHAC KIAA0986 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; autophagy [GO:0006914]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to osmotic stress [GO:0071470]; erythrocyte differentiation [GO:0030218]; exploration behavior [GO:0035640]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; long-term synaptic depression [GO:0060292]; lysosomal protein catabolic process [GO:1905146]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; neuroinflammatory response [GO:0150076]; neuromuscular process controlling balance [GO:0050885]; neuron projection arborization [GO:0140058]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; response to environmental enrichment [GO:0090648]; social behavior [GO:0035176]; sperm mitochondrion organization [GO:0030382] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle lumen [GO:0099013]; sperm midpiece [GO:0097225] GGAAGFFK;GVAAMTMDEDYQQK;IILFTEDPR;ISSIHIRYEDDITNR;ITGAMAK;LLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEK;LSEMRLYRSR;QLMEAKQQELK;SELPDVK;TPEDARWILTK;VGHIGNLKLIIPWK;VKVGHIGNLKLIIPWK 12 4.5 0.97496 -3.5481 13.001 10.7102 0 9.41606 3.59419 0 0 0 11.3937 0 8.69063 0 Q96RN1 S26A8_HUMAN Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8) SLC26A8 TAT1 Homo sapiens (Human) cell differentiation [GO:0030154]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; meiotic cell cycle [GO:0051321]; oxalate transport [GO:0019532]; spermatogenesis [GO:0007283]; sulfate transmembrane transport [GO:1902358] plasma membrane [GO:0005886]; sperm annulus [GO:0097227] bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044] ANSTSILVFLTVVVALRINK;EVYNEETFQQEHKR;TWSVERRR 3 4.3 0.95961 -1.0431 0 0 0 5.82553 6.52691 0 0 0 0 0 0 0 Q96RN5 MED15_HUMAN Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) MED15 ARC105 CTG7A PCQAP TIG1 TNRC7 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] AGVAHSKSSK;LVSQIEDAMRK;MKSLLDILTDPSK;TLQKCEIALEK 4 5.7 0.97452 -3.4697 10.8532 0 0 0 0 0 0 0 0 10.5183 0 0 Q96RP3 UCN2_HUMAN Urocortin-2 (Stresscopin-related peptide) (Urocortin II) (Ucn II) (Urocortin-related peptide) UCN2 SRP URP Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755] extracellular region [GO:0005576]; extracellular space [GO:0005615] corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]; hormone binding [GO:0042562] HPGSRIVLSLDVPIGLLQILLEQARAR 1 24.1 0.69427 0.16215 0 0 0 0 0 0 0 0 0 0 0 8.7938 Q96RP8 KCNA7_HUMAN Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7) KCNA7 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] CPPPCGCCER;FPDTLLGDPAR;FYDDARREYFFDR;VIRLVRVFR 4 9.4 0.94485 -0.64176 0 0 5.58238 2.60436 4.91533 0 0 3.20959 0 0 0 0 Q96RP9 EFGM_HUMAN "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)" GFM1 EFG EFG1 GFM Homo sapiens (Human) mitochondrial translational elongation [GO:0070125] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] SFTPVFLGSALK;VLYYTGRIAK 2 2.9 0.77773 0.034847 0 0 0 0 0 0 12.367 10.0737 0 0 0 0 Q96RQ3 MCCA_HUMAN "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" MCCC1 MCCA Homo sapiens (Human) biotin metabolic process [GO:0006768]; branched-chain amino acid catabolic process [GO:0009083]; L-leucine catabolic process [GO:0006552] cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485] AGDSLMVMIAMK;AVRGGGGK;LGEAAVR;WHRLPSLLLPPR 4 5.4 0.98006 -1.5555 10.7454 0 0 0 7.08332 0 0 9.27815 10.0519 14.0596 5.56837 0 Q96RR1 PEO1_HUMAN "Twinkle mtDNA helicase (EC 5.6.2.3) (Progressive external ophthalmoplegia 1 protein) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Twinkle protein, mitochondrial)" TWNK C10orf2 PEO1 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; protein hexamerization [GO:0034214] mitochondrial chromosome [GO:0000262]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; lipid binding [GO:0008289]; protease binding [GO:0002020]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] GDGAREGFLLSK;KIKDDTGPVAK;KLVTGPGKR;LVTGPGKRYLQVSK;RFSVRYLRPAR;TALPAWHK;WVLLRSGYPLRILLPLR;YLQVSKNR 8 11.1 0.9781 -6.2002 0 0 0 0 7.19436 0 0 7.38172 12.1968 11.3835 9.19626 0 Q96RR4 KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) CAMKK2 CAMKKB KIAA0787 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to reactive oxygen species [GO:0034614]; MAPK cascade [GO:0000165]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of protein kinase activity [GO:0045859] cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] IVVPEIKILVK 1 2.2 0.92595 -0.4525 0 2.60611 0 0 0 0 0 0 0 0 0 0 Q96RS0 TGS1_HUMAN Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) TGS1 HCA137 NCOA6IP PIMT Homo sapiens (Human) 7-methylguanosine cap hypermethylation [GO:0036261]; ribonucleoprotein complex biogenesis [GO:0022613]; spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532] RNA cap trimethylguanosine synthase activity [GO:0071164]; RNA methyltransferase activity [GO:0008173] ILCLCSR;LEITEKWEK;QAETEAEVKKK;TEADDKNDEKCMK;YLDEIVQESWRK 5 6.1 0.97721 -1.4946 0 0 0 8.06507 0 4.98864 2.55807 0 0 0 8.62684 0 Q96RS6 NUDC1_HUMAN NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) NUDCD1 CML66 Homo sapiens (Human) immune system process [GO:0002376] cytosol [GO:0005829]; nucleoplasm [GO:0005654] KNQDNKK 1 1.2 0.60958 0.17598 0 0 0 0 0 0 9.93583 0 0 0 0 0 Q96RT1 ERBIN_HUMAN Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) ERBIN ERBB2IP KIAA1225 LAP2 Homo sapiens (Human) basal protein localization [GO:0045175]; cell adhesion [GO:0007155]; cellular response to tumor necrosis factor [GO:0071356]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular signal transduction [GO:0035556]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; protein targeting [GO:0006605]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165] basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hemidesmosome [GO:0030056]; neuromuscular junction [GO:0031594]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572] ErbB-2 class receptor binding [GO:0005176]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200] AQIPEGDYLSYR;ENQLKMLPK;EQVLRHIEAK;NITVLFLHSNK;YPTPYPDELK 5 3.7 0.97201 -2.7984 0 0 10.9931 7.7652 0 0 10.8721 11.0142 0 11.3818 11.5139 0 Q96RT6 CTGE2_HUMAN cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) CTAGE1 CTAGE2 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] EFEKTIHFYQKK;MDGSMPSEMESSRNDTK 2 3.9 0.86822 -0.093371 0 0 0 0 0 0 0 0 12.1215 0 0 0 Q96RT7 GCP6_HUMAN Gamma-tubulin complex component 6 (GCP-6) TUBGCP6 GCP6 KIAA1669 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017] DKLYWTHGYVLISK;FLLEDEK;VGCPPGHREEPYLTEAGR;VGENVSDVAPTRPR;YLQYYRACVLSTPPTLSLLTIGFLFKK 5 5.2 0.97695 -2.2117 12.0595 10.2793 0 0 0 10.4615 0 10.1851 8.6804 0 0 0 Q96RT8 GCP5_HUMAN Gamma-tubulin complex component 5 (GCP-5) TUBGCP5 GCP5 KIAA1899 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017] KSTEAPFRTYQAFMWALYK;LAPRLSQLKVLHK;LDAQQERDVR;LSISFENVDTAKK;NVPVNHRDFWYATYTLYSVSEK;SLYTLFLESVQSR;VFSTGVAEVPPDTR;YFISFKEELAEIEK 8 11.5 0.97316 -2.5121 0 0 12.7277 7.91773 0 0 7.99095 0 0 0 0 11.8299 Q96RU2 UBP28_HUMAN Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) USP28 KIAA1515 Homo sapiens (Human) cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of protein stability [GO:0031647]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005] AFHEEYSRLYQLAK;EEIKILQQK 2 2.1 0.98082 -1.7793 0 0 0 0 0 0 8.95489 0 0 0 0 0 Q96RU7 TRIB3_HUMAN Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B) TRIB3 C20orf97 NIPK SKIP3 TRB3 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of autophagy [GO:0010506]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of MAP kinase activity [GO:0043405]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106] CLLRREPAER;VYPVQEALAVLEPYARLPPHK 2 8.7 0.77708 0.037166 6.79181 0 8.74675 0 5.24275 0 5.21704 4.21723 6.27988 0 0 0 Q96RU8 TRIB1_HUMAN Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) TRIB1 C8FW GIG2 TRB1 Homo sapiens (Human) JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106] LFKQIVSAVAHCHQSAIVLGDLKLR;LLDADDAAAVAAK;SAMSGASQPR 3 12.9 0.97694 -2.2378 0 0 0 0 0 0 0 0 0 7.83245 0 0 Q96RV3 PCX1_HUMAN Pecanex-like protein 1 (Pecanex homolog protein 1) PCNX1 KIAA0805 KIAA0995 PCNX PCNXL1 Homo sapiens (Human) membrane [GO:0016020] AGRNSWK;DHRPRGVPR;IFPKTEEK;KLNTELGALMITVAGLKLLR;LTLLALFDR;RERSTFR;VLSLDSGTVACLNDSNR 7 3.3 0.97681 -4.8432 11.0496 9.39038 11.0239 0 0 10.2277 0 0 10.1933 0 0 0 Q96RW7 HMCN1_HUMAN Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601] adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] DGTHQCR;ILETSLK;KGSPVLTDSMGRVR;LECEARGIPAPSLTWLK;QVTLECK;SLGSAMR;SQHSDSGNYTCIASNMEGKAQK;YNQICENTRGSYR 8 1.7 0.97492 -3.0747 0 0 0 8.77979 8.54612 0 11.1459 0 0 0 9.40555 5.70551 Q96RY7 IF140_HUMAN Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; intraciliary transport particle A [GO:0030991]; photoreceptor connecting cilium [GO:0032391] AVMLYHK;ITFFASVSR 2 1.1 0.91582 -0.43126 0 0 0 0 0 0 0 0 0 0 0 11.2999 Q96S06 LMF1_HUMAN Lipase maturation factor 1 (Transmembrane protein 112) LMF1 C16orf26 TMEM112 HMFN1876 JFP11 Homo sapiens (Human) protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641] endoplasmic reticulum membrane [GO:0005789] WLIFRIMLGAGLIKIR 1 2.8 0.85285 -0.080005 0 0 0 0 0 0 0 0 0 0 0 8.20565 Q96S15 WDR24_HUMAN GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) WDR24 C16orf21 JFP7 Homo sapiens (Human) autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein K6-linked ubiquitination [GO:0085020]; regulation of autophagy [GO:0010506] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LDRSKGDAR;LPPDFFGVLVR 2 2.5 0.93697 -0.56176 0 0 0 10.1331 0 0 0 0 0 0 0 12.0152 Q96S19 MTL26_HUMAN Methyltransferase-like 26 METTL26 JFP2 C16orf13 Homo sapiens (Human) ASGLLLERMVDMPANNK;CLDSIAATTQAQGLTNVK;NPEWGLR 3 20.6 0.95627 -0.99004 0 0 0 0 0 0 10.9443 0 10.609 0 0 10.5813 Q96S21 RB40C_HUMAN Ras-related protein Rab-40C (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) RAB40C RARL RASL8C Homo sapiens (Human) exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] WIKEIDERQVPTEQAR 1 6.1 0.84897 -0.070459 0 0 0 0 0 0 0 0 0 0 6.63472 0 Q96S37 S22AC_HUMAN Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12) SLC22A12 OATL4 URAT1 UNQ6453/PRO34004 Homo sapiens (Human) cellular homeostasis [GO:0019725]; cellular response to insulin stimulus [GO:0032869]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; response to xenobiotic stimulus [GO:0009410]; urate metabolic process [GO:0046415]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165]; urate transmembrane transporter activity [GO:0015143] KATHGTLGNSVLKSTQF 1 5.1 0.95944 -1.044 0 0 0 0 0 0 9.75644 0 0 0 0 0 Q96S38 KS6C1_HUMAN Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) RPS6KC1 RPK118 Homo sapiens (Human) signal transduction [GO:0007165] early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GESGLVLEGDKEIHQIFEDLDKK;SPEESFDIK 2 3 0.95224 -0.7707 0 0 0 0 0 0 0 0 0 0 0 8.00478 Q96S42 NODAL_HUMAN Nodal homolog NODAL Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; axial mesodermal cell fate specification [GO:0048327]; brain development [GO:0007420]; cell migration involved in gastrulation [GO:0042074]; cell population proliferation [GO:0008283]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; germ cell development [GO:0007281]; heart looping [GO:0001947]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; neural fold formation [GO:0001842]; nodal signaling pathway [GO:0038092]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; primitive streak formation [GO:0090009]; regulation of gastrulation [GO:0010470]; regulation of stem cell population maintenance [GO:2000036]; somatic stem cell population maintenance [GO:0035019]; transforming growth factor beta receptor signaling pathway [GO:0007179]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; morphogen activity [GO:0016015]; type I activin receptor binding [GO:0070698] HPGALEK;RHHLPDRSQLCR 2 5.5 0.94432 -0.63217 0 11.0073 0 7.71438 0 0 0 0 0 0 0 0 Q96S44 PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) TP53RK C20orf64 PRPK Homo sapiens (Human) protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525] cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AAVIKHRFPK;KARPVLKK 2 7.1 0.98065 -1.5982 0 0 8.74994 0 0 8.58823 7.80465 0 0 0 9.89004 0 Q96S52 PIGS_HUMAN GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) PIGS UNQ1873/PRO4316 Homo sapiens (Human) attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020] PSEVARGK 1 1.5 0.91265 -0.33804 0 0 0 0 0 0 7.90635 0 8.45043 0 0 0 Q96S53 TESK2_HUMAN Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) TESK2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] IGSGFFSEVFK;LQEEEQERDR;LSSLKYRVK;TVSVLDPYYRPR 4 7.4 0.97893 -1.99 8.90662 0 8.22882 0 5.92728 0 10.6687 8.31025 8.97802 0 11.1504 0 Q96S55 WRIP1_HUMAN ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) WRNIP1 WHIP Homo sapiens (Human) DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA-templated DNA replication initiation [GO:0030174] membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116] AVDTLAYLSDGDAR 1 2.1 0.78404 0.020871 0 0 10.241 0 0 0 0 0 0 0 0 0 Q96S65 CSRN1_HUMAN Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (Protein URAX1) (TGF-beta-induced apoptosis protein 3) (TAIP-3) CSRNP1 AXUD1 TAIP3 Homo sapiens (Human) apoptotic process [GO:0006915]; face morphogenesis [GO:0060325]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" CQMDHTAFPCGCCR;CQMDHTAFPCGCCREGCENPMGR;EDCGCHCDR;HEKLRQR;LEEVSFLQPYPARRR;RELQALR 6 10.4 0.9751 -2.3789 6.43169 0 6.98607 3.74211 0 5.56459 0 0 0 0 0 9.87315 Q96S66 CLCC1_HUMAN Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) CLCC1 KIAA0761 MCLC Homo sapiens (Human) endoplasmic reticulum calcium ion homeostasis [GO:0032469] chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] chloride channel activity [GO:0005254] LDSLTYK;LGLLAFAQHQAEVAK 2 5.1 0.81508 -0.0044963 0 0 0 9.2658 10.5584 8.91773 10.9794 11.5 11.2593 0 9.05664 0 Q96S79 RSLAB_HUMAN Ras-like protein family member 10B (EC 3.6.5.2) (Ras-like protein VTS58635) (Ras-related protein 17) (RRP17) RASL10B Homo sapiens (Human) positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] plasma membrane [GO:0005886] G protein activity [GO:0003925]; GTP binding [GO:0005525] TWKCGYVECSAK 1 5.9 0.98199 -1.5879 7.63307 0 0 0 0 0 0 0 0 0 0 0 Q96S90 LYSM1_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 1 LYSMD1 SB145 Homo sapiens (Human) nucleoplasm [GO:0005654] AAAQKLKK;MEQIKRANR 2 9.5 0.75319 0.075632 0 0 7.41886 0 0 0 0 0 0 10.904 0 0 Q96S94 CCNL2_HUMAN Cyclin-L2 (Paneth cell-enhanced expression protein) CCNL2 SB138 Homo sapiens (Human) regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] DVINVFHR;ELGFCVHVK;SRSDSPPR;TGRRYER 4 6.2 0.97489 -3.9043 0 0 0 10.571 0 0 0 0 4.62585 0 10.3741 7.31877 Q96S95 CK2N2_HUMAN Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN) CAMK2N2 Homo sapiens (Human) cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202] calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901] RPPKLGQIGRAK 1 15.2 0.87141 -0.095717 0 0 0 0 4.24413 0 0 0 0 0 0 0 Q96S96 PEBP4_HUMAN Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1) PEBP4 CORK1 UNQ1933/PRO4408 Homo sapiens (Human) extracellular exosome [GO:0070062] GSWKMDRFLNR 1 4.8 0.86607 -0.088959 0 0 0 0 0 0 0 0 7.52842 0 0 0 Q96S97 MYADM_HUMAN Myeloid-associated differentiation marker (Protein SB135) MYADM UNQ553/PRO1110 Homo sapiens (Human) establishment of endothelial barrier [GO:0061028]; intracellular signal transduction [GO:0035556]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860] cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726] ALTQPLGLLR 1 3.1 0.050699 0.48692 0 0 0 0 0 0 0 0 0 0 0 9.45076 Q96S99 PKHF1_HUMAN Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15) PLEKHF1 APPD LAPF ZFYVE15 Homo sapiens (Human) apoptotic process [GO:0006915]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; positive regulation of autophagy [GO:0010508]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein localization to plasma membrane [GO:0072659]; vesicle organization [GO:0016050] early endosome [GO:0005769]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] ATGRPPSTEHAAPWIPDK;VLLGEGVLTKECRK 2 11.5 0.96538 -1.1596 0 0 0 0 0 0 0 9.26838 0 0 0 8.32459 Q96SB3 NEB2_HUMAN Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) PPP1R9B PPP1R6 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; negative regulation of cell growth [GO:0030308]; neuron projection development [GO:0031175]; positive regulation of protein localization to actin cortical patch [GO:1904372]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell cycle [GO:0051726]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of cell population proliferation [GO:0042127]; regulation of exit from mitosis [GO:0007096]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of postsynapse assembly [GO:0150052]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545]; RNA splicing [GO:0008380] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of dendritic spine plasma membrane [GO:1990780]; dendrite [GO:0030425]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein phosphatase type 1 complex [GO:0000164]; ruffle membrane [GO:0032587]; spine apparatus [GO:0097444] actin filament binding [GO:0051015]; D2 dopamine receptor binding [GO:0031749]; kinase binding [GO:0019900]; protein kinase activity [GO:0004672]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; transmembrane transporter binding [GO:0044325] AQAAPEKEAAAVAPPER;EAAAVAPPER;RVLEESELARK;VLEESELARKEEMDK 4 4 0.95488 -0.90211 0 0 11.5233 9.75417 0 0 0 0 0 0 11.1787 0 Q96SB4 SRPK1_HUMAN SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) SRPK1 Homo sapiens (Human) "chromosome segregation [GO:0007059]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]; spliceosomal complex assembly [GO:0000245]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] QEESESPVERPLK;YSKEFFTK 2 3.2 0.97783 -2.1655 0 0 0 0 0 9.75691 0 0 0 11.0279 0 0 Q96SB8 SMC6_HUMAN Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) SMC6 SMC6L1 Homo sapiens (Human) cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722] "chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; interchromatin granule [GO:0035061]; mitotic spindle pole [GO:0097431]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] EELDVKHALSYNQR;QEELEDFDKDGDEDECK;RCLTLRCK;VLQALMKR 4 4.3 0.97448 -2.4414 0 6.20963 0 0 7.00529 0 0 0 10.3798 0 0 0 Q96SC8 DMTA2_HUMAN Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) DMRTA2 DMRT5 Homo sapiens (Human) cerebral cortex regionalization [GO:0021796]; dopaminergic neuron differentiation [GO:0071542]; germ cell development [GO:0007281]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; skeletal muscle cell differentiation [GO:0035914]; stem cell fate specification [GO:0048866] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TPLDILTRVFPGHR;YCRWKDCLCAK 2 4.6 0.93656 -0.54831 14.2653 5.10077 0 0 0 0 9.52354 0 0 0 0 0 Q96SF2 TCPQM_HUMAN T-complex protein 1 subunit theta-like 2 (Chaperonin containing T-complex polypeptide 1 subunit 8-like 2) CCT8L2 CESK1 Homo sapiens (Human) protein folding [GO:0006457] chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; calcium-activated potassium channel activity [GO:0015269]; monoatomic anion channel activity [GO:0005253]; unfolded protein binding [GO:0051082] MLSDKGSR;SAEQAVYHGIDAYFQLCQDPR 2 5.2 0.97076 -1.337 0 0 0 0 0 0 0 0 0 5.98598 0 0 Q96SF7 TBX15_HUMAN T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14) TBX15 TBX14 Homo sapiens (Human) cell fate specification [GO:0001708]; embryonic cranial skeleton morphogenesis [GO:0048701]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MSSMEEIQVELQCADLWK 1 3.6 0.78197 0.022629 0 0 0 0 8.63423 0 0 0 0 0 0 0 Q96SI1 KCD15_HUMAN BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15) KCTD15 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260] nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] DFSLLYEEARYYQLQPMVR 1 6.7 0.91828 -0.43587 0 0 0 0 0 0 0 0 0 0 0 7.42139 Q96SI9 STRBP_HUMAN Spermatid perinuclear RNA-binding protein STRBP SPNR Homo sapiens (Human) cell motility [GO:0048870]; mechanosensory behavior [GO:0007638]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] ILDSKAIDLMNALMR;KDGENVSMK;NPVMELNEK;VLEMDPLPSSKPFQK;YSWSVTDK 5 8.3 0.98066 -1.66 0 4.86602 9.42078 0 0 0 12.4788 0 0 9.84894 0 0 Q96SK3 ZN607_HUMAN Zinc finger protein 607 ZNF607 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KPYECNK;SILEVHQR 2 2.2 0.96114 -1.0599 0 0 0 0 0 0 0 0 0 0 12.9311 0 Q96SL4 GPX7_HUMAN Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) (CL683) GPX7 GPX6 UNQ469/PRO828 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] catalase activity [GO:0004096]; glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601] YLAQTSGKEPTWNFWK 1 8.6 0.98052 -1.6148 0 0 0 0 0 12.714 0 0 0 0 0 0 Q96SM3 CPXM1_HUMAN Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1) CPXM1 CPX1 CPXM UNQ3015/PRO9782 Homo sapiens (Human) proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AVIKWMKR 1 1.1 0.87041 -0.095167 0 0 6.91576 0 0 0 0 0 0 0 0 0 Q96SN8 CK5P2_HUMAN CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5RAP2 CEP215 KIAA1633 Homo sapiens (Human) brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of neuron differentiation [GO:0045664] cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922] calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631] DLEVIQQNCYLMAAEDLELR;ELQEREQLLIK;IFALRKQLEQDVLSYQNLR;IYFLEER;KVSDLIQLVK;LEKLFLNGK;LFEQEKKLQNTMK;LSCEAQLVK;LTLEEAYRRLK;QEKVIFDQLVVTHKILR;TLEEQISEIR 11 7.2 0.97779 -6.0559 4.37323 0 12.9469 0 14.1572 0 12.2864 11.716 0 14.0343 14.2914 11.2597 Q96SQ5 ZN587_HUMAN Zinc finger protein 587 ZNF587 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DGCYVCSDCGK;ECGKLFNR;SFSECSSLIKHRR 3 5.6 0.975 -3.6195 0 0 0 0 0 0 0 11.7006 0 8.70376 0 10.1653 Q96SQ7 ATOH8_HUMAN Transcription factor ATOH8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6) (Protein atonal homolog 8) ATOH8 ATH6 BHLHA21 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; formation of primary germ layer [GO:0001704]; myoblast proliferation [GO:0051450]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; tube formation [GO:0035148] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" KSWRLEFLFLR 1 2.6 0.86826 -0.093391 0 0 0 0 6.98687 0 0 0 0 0 0 0 Q96SQ9 CP2S1_HUMAN Cytochrome P450 2S1 (EC 1.14.14.-) (CYPIIS1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Thromboxane-A synthase) (EC 5.3.99.5) CYP2S1 UNQ891/PRO1906 Homo sapiens (Human) cytochrome metabolic process [GO:1903604]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693]; retinoic acid metabolic process [GO:0042573]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydro-lyase activity [GO:0016836]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; thromboxane-A synthase activity [GO:0004796]" ELGAGQAPSLGDRTR;FLDADGR 2 4.4 0.96707 -1.3083 0 0 0 10.3449 0 0 0 0 0 0 0 0 Q96SR6 ZN382_HUMAN Zinc finger protein 382 (KRAB/zinc finger suppressor protein 1) (KS1) (Multiple zinc finger and krueppel-associated box protein KS1) ZNF382 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AYECPQCGSAFRK;IFPSYSYLEEDGK;SNLIVHQKTHK 3 6.7 0.97956 -1.8482 0 0 0 10.4612 8.47297 8.90629 0 0 3.6368 0 0 11.6554 Q96ST2 IWS1_HUMAN Protein IWS1 homolog (IWS1-like protein) IWS1 IWS1L Homo sapiens (Human) chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DYVVRPKWNVEMESSRFQATSK;KLTLLPAVVMHLKK;KPALKKLTLLPAVVMHLK 3 5 0.25546 0.2727 0 0 0 0 0 0 0 5.37549 0 6.54436 8.49629 0 Q96ST3 SIN3A_HUMAN Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) SIN3A Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to dopamine [GO:1903351]; cellular response to glucose stimulus [GO:0071333]; cellular response to tert-butyl hydroperoxide [GO:0072736]; cerebral cortex neuron differentiation [GO:0021895]; DNA replication [GO:0006260]; hematopoietic progenitor cell differentiation [GO:0002244]; heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of stem cell population maintenance [GO:1902459]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of hormone levels [GO:0010817]; response to methylglyoxal [GO:0051595]; rhythmic process [GO:0048511]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] AFLEILHTYQKEQRNAK;ALQRIYADK;DKSDSPAIQLR;FPELFNWFKNFLGYK;LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMK;LSAEEQAK;SLDHQGINFK 7 8 0.97606 -5.2148 9.88324 0 0 9.0217 10.2915 9.02042 9.34607 8.93068 11.0657 0 8.83643 7.93345 Q96ST8 CEP89_HUMAN Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) CEP89 CCDC123 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrion organization [GO:0007005]; non-motile cilium assembly [GO:1905515] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; spindle pole [GO:0000922]; synapse [GO:0045202] DELNATLKEEMR;IAVEVHKSIVNELKSQLQK;QEVLDQALQQNR;RSHFKHIIHGLLPAASVAPK 4 8 0.95186 -0.74565 6.12511 0 0 2.69394 0 0 0 0 0 0 8.41857 0 Q96SU4 OSBL9_HUMAN Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) OSBPL9 ORP9 OSBP4 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020] sterol binding [GO:0032934]; sterol transfer activity [GO:0120015] KIETLKETTNSMVESIK 1 2.3 0.97634 -1.4672 0 0 0 0 0 0 0 9.17617 8.92713 0 0 0 Q96SW2 CRBN_HUMAN Protein cereblon CRBN AD-006 Homo sapiens (Human) locomotory exploration behavior [GO:0035641]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of Wnt signaling pathway [GO:0030177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] AGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSK 1 8.6 0.76515 0.063786 9.90776 0 0 0 0 0 0 0 0 0 0 0 Q96SZ4 ZSC10_HUMAN Zinc finger and SCAN domain-containing protein 10 (Zinc finger protein 206) ZSCAN10 ZNF206 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" FVRRASLAR;LEEEEAVSPEDPR;SFLCLCCGKSFGR;TPDKEEFKQEEPK 4 6.2 0.98174 -1.5827 6.94544 0 0 0 0 0 0 0 6.50198 7.3166 0 11.3068 Q96SZ6 CK5P1_HUMAN Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase) CDK5RAP1 C20orf34 CGI-05 HSPC167 Homo sapiens (Human) brain development [GO:0007420]; mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of neuron differentiation [GO:0045664]; RNA modification [GO:0009451] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597]; protein kinase binding [GO:0019901]" AEQTIWNR;KLSEQVLQLIHER 2 4.1 0.93515 -0.53009 0 0 0 0 0 8.34314 0 0 0 0 0 0 Q96T17 MA7D2_HUMAN MAP7 domain-containing protein 2 MAP7D2 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] KAGEEAK;LEAMMRR;LEREELKR;RSLERTQQLELK;TSQPNYRPQGMEGFLK 5 6.7 0.98078 -1.7276 0 15.0719 9.29513 0 0 10.4735 0 0 0 0 8.40109 0 Q96T21 SEBP2_HUMAN Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) SECISBP2 SBP2 Homo sapiens (Human) "forebrain neuron development [GO:0021884]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; RNA catabolic process [GO:0006401]; selenocysteine incorporation [GO:0001514]; striatum development [GO:0021756]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368] GKQREIPK;LVLGLREVLKHLK 2 2.5 0.88784 -0.19044 6.24007 5.66605 0 0 0 2.98486 0 0 0 4.74551 0 0 Q96T23 RSF1_HUMAN Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) RSF1 HBXAP XAP8 Homo sapiens (Human) chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSF complex [GO:0031213] histone binding [GO:0042393]; histone octamer slider activity [GO:0140751]; metal ion binding [GO:0046872] AQIDPVLLK;DISTITGHRGK;EDSESDGSQK;GYLEMSVECK;KYSDDDEEEESEENSR;VAEIRDQKADK;YGPLLDLPELPFPELER;YSDDDEEEESEENSR 8 5.8 0.97971 -1.9977 0 0 11.2852 7.3345 10.7396 6.18446 0 11.1928 4.611 5.95147 11.0306 7.62899 Q96T37 RBM15_HUMAN RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RBM15 OTT OTT1 Homo sapiens (Human) "branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]" nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; RNA binding [GO:0003723] GGGGESR;GQTSTYGFLK;LVEQRMK;SLHLDKSSSR;TDSGGGSR;VGAGAGAAPFR 6 5.5 0.97618 -4.4921 0 0 0 0 0 0 0 0 8.68937 0 9.95212 0 Q96T49 PP16B_HUMAN Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP) PPP1R16B ANKRD4 KIAA0823 Homo sapiens (Human) establishment of endothelial barrier [GO:0061028]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of filopodium assembly [GO:0051489]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of sprouting angiogenesis [GO:1903670] cell projection [GO:0042995]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein phosphatase regulator activity [GO:0019888] TGESSSEGKAPLIGGR 1 2.8 0.81227 -0.013641 0 0 0 0 0 7.19338 0 0 0 0 0 0 Q96T51 RUFY1_HUMAN RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) RUFY1 RABIP4 ZFYVE12 Homo sapiens (Human) early endosome to Golgi transport [GO:0034498]; endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607] identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] LELEKELELQIGMK;SFIGQNK;TEMEIAMKLLEKDTHEK 3 5.4 0.91699 -0.41287 7.31687 0 0 0 7.90026 0 0 0 0 6.90761 0 0 Q96T53 MBOA4_HUMAN Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4) MBOAT4 GOAT OACT4 FKSG89 Homo sapiens (Human) lipid modification [GO:0030258]; peptide hormone processing [GO:0016486]; peptidyl-serine octanoylation [GO:0018191] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; O-acyltransferase activity [GO:0008374]; serine O-acyltransferase activity [GO:0016412]" AASGGFR 1 2.1 0.82277 -0.017935 0 0 0 0 0 9.37263 0 0 0 0 9.85064 0 Q96T58 MINT_HUMAN Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) SPEN KIAA0929 MINT SHARP Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of neurogenesis [GO:0050769]; random inactivation of X chromosome [GO:0060816]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] EGRLKAR;EYSYRQR;FADSNLKAEK;LAEASASAAYK;LDGASDNRER;NDPYEQDIREYSYR;NIFQRFGEIVDIDIK;NIFQRFGEIVDIDIKK;RRFADSNLK;TFDPERVERER 10 2.3 0.97804 -6.9188 5.57993 6.76381 0 11.9434 0 0 0 11.4812 0 0 13.9035 0 Q96T66 NMNA3_HUMAN Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMN/NaMN adenylyltransferase 3) (Nicotinamide-nucleotide adenylyltransferase 3) (NMN adenylyltransferase 3) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1) NMNAT3 FKSG76 Homo sapiens (Human) NAD biosynthetic process [GO:0009435]; nucleotide biosynthetic process [GO:0009165]; response to tumor necrosis factor [GO:0034612]; response to wounding [GO:0009611] axon [GO:0030424]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515] DAHIQEIVEK;DLAASHHRVAMARLALQTSDWIR 2 13.1 0.93635 -0.52302 12.2754 0 0 0 0 0 8.71942 9.35614 0 0 0 0 Q96T68 SETB2_HUMAN Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) SETDB2 C13orf4 CLLD8 KMT1F Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; heart looping [GO:0001947]; heterochromatin organization [GO:0070828]; left/right axis specification [GO:0070986]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; zinc ion binding [GO:0008270] TELTWDYGYEAGTVPEK;TSPLSSDKITTGYK 2 4.3 0.90439 -0.26845 0 0 0 0 8.47237 0 0 0 0 7.32607 0 0 Q96T76 MMS19_HUMAN MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein) MMS19 MMS19L Homo sapiens (Human) chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; protein maturation by iron-sulfur cluster transfer [GO:0097428] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; membrane [GO:0016020]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIIH holo complex [GO:0005675] enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor complex adaptor activity [GO:0030159]; transcription coactivator activity [GO:0003713] AGHAEVRIMFR;LPTPVLLPYKPQVIR;NVEIPQLNQLMR 3 3.7 0.74492 0.099797 10.8426 4.96514 5.20656 0 0 0 9.44601 0 0 4.40735 0 0 Q96T83 SL9A7_HUMAN Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) SLC9A7 NHE7 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; sodium ion import across plasma membrane [GO:0098719] Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] LLLLPLLLGWGLR 1 1.8 0.80899 0.0096286 0 0 0 0 0 0 0 0 0 2.01514 0 0 Q96T88 UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) UHRF1 ICBP90 NP95 RNF106 Homo sapiens (Human) DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; homologous recombination [GO:0035825]; mitotic spindle assembly [GO:0090307]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of epithelial cell proliferation [GO:0050678]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; spindle [GO:0005819] cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA damage sensor activity [GO:0140612]; H3K9me3 modified histone binding [GO:0062072]; hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3 ubiquitin ligase activity [GO:0141055]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IQELFHVEPGLQRLFYR;LTKVEELR;SAGGGPSR;WIQVRTMDGR 4 5.4 0.98068 -1.6474 13.4685 0 0 0 0 0 0 0 0 10.3198 10.4552 10.2687 Q96T88 UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) UHRF1 ICBP90 NP95 RNF106 Homo sapiens (Human) DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; homologous recombination [GO:0035825]; mitotic spindle assembly [GO:0090307]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of epithelial cell proliferation [GO:0050678]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; spindle [GO:0005819] cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA damage sensor activity [GO:0140612]; H3K9me3 modified histone binding [GO:0062072]; hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3 ubiquitin ligase activity [GO:0141055]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GVFAVPPLSSDTMWIQVRTMDGR;IQELFHVEPGLQRLFYR;LTKVEELR;SAGGGPSR 4 6.9 0.83357 -0.029624 0 0 8.42681 0 0 0 0 0 0 0 0 0 Q96T91 GPHA2_HUMAN Glycoprotein hormone alpha-2 (Putative secreted protein Zsig51) (Thyrostimulin subunit alpha) GPHA2 GPA2 ZSIG51 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; protein heterodimerization activity [GO:0046982]; thyrotropin-releasing hormone receptor binding [GO:0031531] ACQCDMCR 1 6.2 0.91581 -0.39033 0 0 0 0 0 4.33992 0 0 0 0 0 0 Q96T92 INSM2_HUMAN Insulinoma-associated protein 2 (Zinc finger protein IA-6) INSM2 IA6 Nbla106 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of cell cycle process [GO:0010564] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KLSFADEVTTSPVLGLK 1 3 0.29616 0.25276 0 0 0 0 0 0 10.5596 0 0 0 0 0 Q96TA1 NIBA2_HUMAN Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) NIBAN2 C9orf88 FAM129B Homo sapiens (Human) axon guidance [GO:0007411]; cell differentiation [GO:0030154]; gonadotropin secretion [GO:0032274]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription regulatory region DNA binding [GO:2000679] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713] FDVSSTSVFK;HCNNGIPEDSK;HYYFCMMTEAEQDK;LDGLQQR;TDMDQIITSK;VQQVQPAMQAVIR 6 8.7 0.0045872 1.2766 0 0 0 0 0 0 0 0 0 11.1073 6.23569 0 Q96TA2 YMEL1_HUMAN ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) YME1L1 FTSH1 YME1L UNQ1868/PRO4304 Homo sapiens (Human) cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mitochondrial fusion [GO:0010636]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of stem cell division [GO:2000035] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent peptidase activity [GO:0004176]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EMVTMKELEFSK;LPKGILLVGPPGTGK;NIPEAHQDAFK;NISSHWHTSHVSAQSFFENK 4 7.5 0.9632 -1.0917 0 11.0732 0 6.64688 0 0 0 8.76921 8.90159 0 0 0 Q99062 CSF3R_HUMAN Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) CSF3R GCSFR Homo sapiens (Human) amelogenesis [GO:0097186]; cell adhesion [GO:0007155]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell population proliferation [GO:0008284]; regulation of myeloid cell differentiation [GO:0045637]; signal transduction [GO:0007165] endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; granulocyte colony-stimulating factor binding [GO:0051916]; signaling receptor activity [GO:0038023] LTVLEEDEK 1 1.1 0.9159 -0.37509 0 0 0 0 0 0 10.1599 0 0 0 0 0 Q99075 HBEGF_HUMAN Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] HBEGF DTR DTS HEGFL Homo sapiens (Human) "cell chemotaxis [GO:0060326]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; muscle organ development [GO:0007517]; negative regulation of elastin biosynthetic process [GO:0051545]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of wound healing [GO:0090303]; regulation of heart contraction [GO:0008016]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] KLLPSVVLKLFLAAVLSALVTGESLER 1 13 0.69462 0.16215 0 0 3.8056 0 0 0 0 5.97101 0 0 0 0 Q99102 MUC4_HUMAN Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)] MUC4 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982] "ErbB-2 class receptor binding [GO:0005176]; extracellular matrix constituent, lubricant activity [GO:0030197]" IGLASALQPR;TVVCHCNAESQCLYNQTSR 2 0.5 0.93744 -0.5408 0 0 0 0 0 0 0 0 0 0 6.23368 0 Q99102 MUC4_HUMAN Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)] MUC4 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982] "ErbB-2 class receptor binding [GO:0005176]; extracellular matrix constituent, lubricant activity [GO:0030197]" ATPTKPSSPRTGAGPMPCFSTR 1 0.5 0.93604 -0.51867 0 0 0 10.0399 0 0 0 0 0 0 0 0 Q99250 SCN2A_HUMAN Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) SCN2A HBA NAC2 SCN2A1 SCN2A2 Homo sapiens (Human) cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to hypoxia [GO:0071456]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; memory [GO:0007613]; myelination [GO:0042552]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] axon [GO:0030424]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518] calmodulin binding [GO:0005516]; voltage-gated sodium channel activity [GO:0005248] GKECDGTPIK;KLGSKKPQKPIPRPANK;KQKEQSGEEEK;TISVIPGLKTIVGALIQSVK;TLRALRPLRALSR;TVSIFNWDEYIEDK;VLRALKTISVIPGLK 7 4.5 0.9769 -2.2187 0 12.0583 3.80818 0 4.42962 8.71846 0 0 10.8694 7.89627 0 0 Q99259 DCE1_HUMAN Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform) GAD1 GAD GAD67 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; gamma-aminobutyrate shunt [GO:0006540]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate catabolic process [GO:0006538]; locomotory exploration behavior [GO:0035641]; social behavior [GO:0035176] axon terminus [GO:0043679]; cell cortex [GO:0005938]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; vesicle membrane [GO:0012506] glutamate decarboxylase activity [GO:0004351]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] AGAALGFGTDNVILIKCNER;DTLKYGVR;IIPADFEAK 3 6.2 0.97907 -1.9713 0 0 0 0 0 0 0 11.0825 0 0 0 0 Q99417 MYCBP_HUMAN c-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] AADSKREQFR;SGVLDTLTK 2 18.4 0.89749 -0.25549 0 0 0 0 0 9.72264 0 0 10.2063 0 0 0 Q99424 ACOX2_HUMAN "Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox)" ACOX2 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity [GO:0033791]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; protein homodimerization activity [GO:0042803]" VLDYQTQQQK 1 1.5 0.77734 0.041016 0 0 0 0 0 0 0 0 0 0 0 2.6345 Q99426 TBCB_HUMAN Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) TBCB CG22 CKAP1 Homo sapiens (Human) cell differentiation [GO:0030154]; cytoplasmic microtubule organization [GO:0031122]; nervous system development [GO:0007399]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] alpha-tubulin binding [GO:0043014]; microtubule plus-end binding [GO:0051010] AAGQSPR 1 2.9 0.81324 -0.0091555 0 0 0 0 0 0 0 10.7378 0 0 0 0 Q99435 NELL2_HUMAN Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2) NELL2 NRP2 Homo sapiens (Human) commissural neuron axon guidance [GO:0071679]; fertilization [GO:0009566]; neuron cellular homeostasis [GO:0070050] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080] AEQRMNRLDQCYCER;LLILILK;LLILILKIGR;LSRAEQR;RLLILILKIGR;SIRRLLILILK;VKHNGQIWVLENDR 7 5.5 0.97637 -1.479 0 3.05261 0 4.066 10.4048 0 5.03289 0 0 0 3.82731 7.08821 Q99436 PSB7_HUMAN Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) (Proteasome subunit beta-2) (beta-2) PSMB7 Z Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774]" endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298] QMLFRFWLLGSNGCI 1 10.6 0.9149 -0.43428 0 0 0 0 6.7666 0 0 0 0 0 0 0 Q99440 CD006_HUMAN Uncharacterized protein encoded by LINC01587 (Protein AC1) LINC01587 AC1 C4orf6 Homo sapiens (Human) nervous system development [GO:0007399] THNSKNQFFTIFFFLSVEFGKEGTR 1 26.9 0.66314 0.16893 11.5498 0 0 0 0 0 0 0 0 0 0 0 Q99442 SEC62_HUMAN Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 TLOC1 Homo sapiens (Human) "cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] signaling receptor activity [GO:0038023] AESGKEEDKK 1 2.5 0.95519 -0.80466 0 0 0 0 0 0 0 0 0 8.73142 0 0 Q99445 GML_HUMAN Glycosyl-phosphatidylinositol-anchored molecule-like protein GML LY6DL Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of cell population proliferation [GO:0008285]" extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DMLPDEVTEEELPEGTVR 1 11.4 0.83946 -0.039705 0 0 0 0 0 0 0 0 0 0 9.74475 0 Q99456 K1C12_HUMAN "Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)" KRT12 Homo sapiens (Human) cornea development in camera-type eye [GO:0061303]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ADAERQNVDHQR;IREWYETR;LAAEDFRMK;LASYLDK;LASYLDKVR;VLDELTLTR 6 9.5 0.97461 -3.1238 0 0 6.04078 0 0 9.93015 0 0 0 11.1379 10.924 0 Q99457 NP1L3_HUMAN Nucleosome assembly protein 1-like 3 NAP1L3 BNAP Homo sapiens (Human) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] MAEADFK 1 1.4 0.9126 -0.32188 0 0 0 0 0 0 0 0 0 0 0 4.66141 Q99459 CDC5L_HUMAN Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) CDC5L KIAA0432 PCDC5RP Homo sapiens (Human) "DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]" LANTQGK;VGQASEIAR 2 2 0.95479 -0.95068 0 0 0 0 0 0 0 9.03337 0 0 0 0 Q99460 PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) PSMD1 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] "azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]" enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625] HGGSLGLGLAAMGTAR;KKEPEPNFQLLDNPAR;QDVYDLLK;VSTAVLSITAK 4 5.4 0.97389 -2.4617 0 0 10.3154 0 0 9.34928 0 0 0 0 0 0 Q99466 NOTC4_HUMAN Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain] NOTCH4 INT3 Homo sapiens (Human) branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; endothelial cell morphogenesis [GO:0001886]; epithelial to mesenchymal transition [GO:0001837]; hemopoiesis [GO:0030097]; luteolysis [GO:0001554]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; vasculature development [GO:0001944] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023]" CEEDIDECR;DRDGRDMVYPYPGAR;EAGPFPR;FSRPTAAR;LEDPCPPSFCSK;QPPSLLLLLLLLLLLCVSVVRPR;RRPPLGEDSIGLKALKPK;SLLQAGADKDAQDNR;TVSVSVPPHGGGALPRCR;TWSVDLAAR 10 6.7 0.97308 -2.9164 0 0 0 8.81858 9.68412 0 0 5.087 0 0 7.7066 7.83276 Q99467 CD180_HUMAN CD180 antigen (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) (CD antigen CD180) CD180 LY64 RP105 Homo sapiens (Human) B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GLPSGMK;GNHFQDGTITK 2 2.7 0.63086 0.17358 0 0 0 0 4.17329 0 0 0 0 0 8.69613 0 Q99471 PFD5_HUMAN Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) PFDN5 MM1 PFD5 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; retina development in camera-type eye [GO:0060041]; RNA polymerase I assembly [GO:1990113]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase III assembly [GO:1990115] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082] QAVMEMMSQK 1 6.5 0.96471 -1.2269 10.1701 10.263 0 0 0 0 0 0 0 0 0 0 Q99471 PFD5_HUMAN Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) PFDN5 MM1 PFD5 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]; retina development in camera-type eye [GO:0060041]; RNA polymerase I assembly [GO:1990113]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase III assembly [GO:1990115] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082] SNEDVCPWEAA 1 16.7 0.89762 -0.23894 0 0 0 7.51657 0 0 0 0 0 6.8802 0 0 Q99489 OXDD_HUMAN D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320]; nervous system process [GO:0050877]; regulation of cell communication [GO:0010646] cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949] DTARIAVVGAGVVGLSTAVCISK;GSGGWTLTRR;LQTELLAR 3 12 0.93704 -0.53994 0 0 0 0 0 0 8.29705 0 9.90126 0 0 0 Q99490 AGAP2_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)" AGAP2 CENTG1 KIAA0167 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; endosomal transport [GO:0016197]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of protein kinase activity [GO:0045860]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] GETTGSGR;TVTTSGAKAGGGK 2 1.8 0.84944 -0.077933 0 0 0 0 0 0 0 0 10.6089 0 0 6.49731 Q99496 RING2_HUMAN E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) RNF2 BAP1 DING HIPI3 RING1B Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; chromatin remodeling [GO:0006338]; epigenetic regulation of gene expression [GO:0040029]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; germ cell development [GO:0007281]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; euchromatin [GO:0000791]; MLL1 complex [GO:0071339]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] SGLQRGK 1 2.7 0.89916 -0.25811 0 8.91636 0 0 0 0 0 10.4457 0 0 0 0 Q99497 PARK7_HUMAN "Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)" PARK7 Homo sapiens (Human) "adult locomotory behavior [GO:0008344]; androgen receptor signaling pathway [GO:0030521]; autophagy [GO:0006914]; cellular detoxification of aldehyde [GO:0110095]; cellular detoxification of methylglyoxal [GO:0140041]; cellular response to glyoxal [GO:0036471]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; detection of oxidative stress [GO:0070994]; detoxification of copper ion [GO:0010273]; detoxification of hydrogen peroxide [GO:0061691]; detoxification of mercury ion [GO:0050787]; DNA repair [GO:0006281]; dopamine uptake involved in synaptic transmission [GO:0051583]; glucose homeostasis [GO:0042593]; glycolate biosynthetic process [GO:0046295]; glyoxal metabolic process [GO:1903189]; guanine deglycation [GO:0106044]; guanine deglycation, glyoxal removal [GO:0106046]; guanine deglycation, methylglyoxal removal [GO:0106045]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; lactate biosynthetic process [GO:0019249]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; methylglyoxal catabolic process to lactate [GO:0061727]; methylglyoxal metabolic process [GO:0009438]; mitochondrion organization [GO:0007005]; negative regulation of death-inducing signaling complex assembly [GO:1903073]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of TRAIL-activated apoptotic signaling pathway [GO:1903122]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of L-dopa biosynthetic process [GO:1903197]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein repair [GO:0030091]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of inflammatory response [GO:0050727]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of supramolecular fiber organization [GO:1902903]; regulation of synaptic vesicle endocytosis [GO:1900242]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; single fertilization [GO:0007338]" adherens junction [GO:0005912]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; PML body [GO:0016605]; synaptic vesicle [GO:0008021] "cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; cytokine binding [GO:0019955]; DNA-binding transcription factor binding [GO:0140297]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; glyoxalase (glycolic acid-forming) activity [GO:1990422]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-dopa decarboxylase activator activity [GO:0036478]; mercury ion binding [GO:0045340]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; oxygen sensor activity [GO:0019826]; peptidase activity [GO:0008233]; peptidase inhibitor activity [GO:0030414]; peroxiredoxin activity [GO:0051920]; protein deglycase activity [GO:0036524]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; small protein activating enzyme binding [GO:0044388]; superoxide dismutase copper chaperone activity [GO:0016532]; transcription coactivator activity [GO:0003713]; tyrosine 3-monooxygenase activator activity [GO:0036470]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; ubiquitin-specific protease binding [GO:1990381]" APLVLKD;DGLILTSR;GAEEMETVIPVDVMR 3 15.9 0.017274 0.71257 9.29662 10.4215 0 9.01408 8.59276 6.8846 0 10.6824 10.9953 9.59826 9.6719 0 Q99500 S1PR3_HUMAN Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) S1PR3 C9orf108 C9orf47 EDG3 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of establishment of endothelial barrier [GO:1903141]; Notch signaling pathway [GO:0007219]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-1 beta production [GO:0032651]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; presynapse [GO:0098793] G protein-coupled receptor activity [GO:0004930]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036] ATALPPR;LVCNCLVRGR;VNILMSGKK 3 6.9 0.97772 -1.5204 0 0 0 0 0 9.49273 8.64623 0 0 0 13.2588 0 Q99501 GA2L1_HUMAN GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) GAS2L1 GAR22 Homo sapiens (Human) actin crosslink formation [GO:0051764]; cellular response to starvation [GO:0009267]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; protein localization to microtubule plus-end [GO:1904825]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017] ADPVAGIAGSAAK;GSGGSGR;IPTPRGPR 3 4.1 0.98109 -1.7515 0 0 0 0 8.75502 0 0 8.05105 0 9.77568 0 0 Q99518 FMO2_HUMAN Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) FMO2 Homo sapiens (Human) energy homeostasis [GO:0097009]; NADP metabolic process [GO:0006739]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; oxygen metabolic process [GO:0072592]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" AKKVAVIGAGVSGLISLK 1 3.4 0.96365 -1.1086 0 8.393 0 0 0 0 0 0 0 0 0 0 Q99519 NEUR1_HUMAN Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) NEU1 NANH Homo sapiens (Human) ganglioside catabolic process [GO:0006689]; oligosaccharide catabolic process [GO:0009313] cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] alpha-sialidase activity [GO:0016997]; exo-alpha-sialidase activity [GO:0004308] DGVFCLLSDDHGASWR 1 3.9 0.78298 0.026223 0 0 0 0 0 0 0 9.62759 0 0 0 0 Q99523 SORT_HUMAN Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) SORT1 Homo sapiens (Human) D-glucose import [GO:0046323]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; G protein-coupled receptor signaling pathway [GO:0007186]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; maintenance of synapse structure [GO:0099558]; myotube differentiation [GO:0014902]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of lipoprotein lipase activity [GO:0051005]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; protein targeting to lysosome [GO:0006622]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050] cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140] "enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G protein-coupled [GO:0030379]; retromer complex binding [GO:1905394]" SNSVPIILAIVGLMLVTVVAGVLIVKK;TFGQSKLYR 2 5.2 0.9722 -1.3631 0 9.81622 0 6.47573 0 0 0 0 0 0 0 0 Q99525 H4G_HUMAN Histone H4-like protein type G (H4-clustered histone 7) H4C7 H4/L H4FL HIST1H4G Homo sapiens (Human) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] GGAKCHRK 1 8.2 0.97595 -1.4842 0 0 0 0 0 0 0 11.129 0 0 0 0 Q99527 GPER1_HUMAN G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER) GPER1 CEPR CMKRL2 DRY12 GPER GPR30 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic chromosome condensation [GO:0030263]; cell differentiation [GO:0030154]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cell cycle process [GO:0010948]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nervous system development [GO:0007399]; neuronal action potential [GO:0019228]; nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac vascular smooth muscle cell differentiation [GO:2000724]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of insulin secretion [GO:0032024]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; steroid hormone receptor signaling pathway [GO:0043401]; vasodilation [GO:0042311] axon [GO:0030424]; axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine head [GO:0044327]; dendritic spine membrane [GO:0032591]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; keratin filament [GO:0045095]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] chromatin binding [GO:0003682]; G protein-coupled estrogen receptor activity [GO:0038054]; G protein-coupled receptor activity [GO:0004930]; nuclear estrogen receptor activity [GO:0030284]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239] AMRCSLFRTK;HRGLRPR 2 4.5 0.97212 -2.7936 0 0 0 0 0 0 14.8724 0 0 0 0 0 Q99538 LGMN_HUMAN "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)" LGMN PRSC1 Homo sapiens (Human) activation of cysteine-type endopeptidase activity [GO:0097202]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; cellular response to calcium ion [GO:0071277]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; dendritic spine organization [GO:0097061]; memory [GO:0007613]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of monocyte chemotaxis [GO:0090026]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; response to acidic pH [GO:0010447]; self proteolysis [GO:0097264]; vacuolar protein processing [GO:0006624]; vitamin D metabolic process [GO:0042359] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activator activity [GO:0061133]; peptidase activity [GO:0008233]; tau protein binding [GO:0048156] THCFNWHSPTYEYALR;TISTMKVMQFQGMKR 2 7.2 0.95489 -0.81616 8.78676 0 0 0 0 0 4.74384 0 7.42139 0 0 11.5051 Q99543 DNJC2_HUMAN "DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]" DNAJC2 MPHOSPH11 MPP11 ZRF1 Homo sapiens (Human) 'de novo' cotranslational protein folding [GO:0051083]; DNA replication [GO:0006260]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular response to heat [GO:1900034]; regulation of translational fidelity [GO:0006450] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATPase activator activity [GO:0001671]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; ubiquitin-modified histone reader activity [GO:0061649] KAAGEPIK;KFKEEEK;LDPHQKDDINK;QIEEINEQIRK;TLDPKDWK 5 7.2 0.97951 -1.8538 0 0 12.2161 0 0 0 9.64147 9.4374 0 10.5915 10.6939 2.61615 Q99550 MPP9_HUMAN M-phase phosphoprotein 9 MPHOSPH9 MPP9 Homo sapiens (Human) negative regulation of cilium assembly [GO:1902018] centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] AYYESEINSLK;IFKNWGTQTEK;LKQNQPK;LLDAYTQISDLK;QKLEAKEISGVEDWK 5 4.7 0.98077 -1.6342 12.6334 0 7.42534 0 0 0 11.8508 0 9.24434 6.19509 0 0 Q99551 MTEF1_HUMAN "Transcription termination factor 1, mitochondrial (Mitochondrial transcription termination factor 1) (mTERF) (mTERF1)" MTERF1 MTERF Homo sapiens (Human) DNA geometric change [GO:0032392]; DNA-templated transcription termination [GO:0006353]; regulation of DNA-templated transcription [GO:0006355]; termination of mitochondrial transcription [GO:0006393] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] double-stranded DNA binding [GO:0003690]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] FVLSYPDVIFLAEKKFNDK;IVTSDLEIVNILER 2 8.3 0.23289 0.29565 0 0 0 0 0 0 0 0 0 10.8605 10.873 0 Q99558 M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) MAP3K14 NIK Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune response [GO:0006955]; MAPK cascade [GO:0000165]; non-canonical NF-kappaB signal transduction [GO:0038061] cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] AEELMACAGLTSPR;EQGCLPEDR;IVPLYGAVR;LACVDSQKPLPDPHLSK;LHHPQDGGPLPLPTHPFPYSR 5 7.4 0.955 -0.80506 0 7.44327 5.3837 0 0 6.66676 0 4.31571 0 0 0 12.275 Q99567 NUP88_HUMAN Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) NUP88 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] structural constituent of nuclear pore [GO:0017056] QVTMKKDYQQQK 1 1.6 0.86639 -0.092753 0 0 0 0 0 0 0 11.1699 0 0 0 0 Q99569 PKP4_HUMAN Plakophilin-4 (p0071) PKP4 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; regulation of cell adhesion [GO:0030155] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] cadherin binding [GO:0045296] AEGQTLVQPSVANR;LQHQQLYYSQDDSNRKNFDAYR;MPAPEQASLVEEGQPQTR;NLSSAGEEARK;NVGGIPALLRLLRK;SSYASQHSQLGQDLR 6 7.9 0.89689 -0.24044 10.8147 7.36623 0 0 0 0 0 0 11.0604 7.3127 6.60374 7.14944 Q99570 PI3R4_HUMAN Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) PIK3R4 VPS15 Homo sapiens (Human) autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241] "autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LAALELILHLAPRLSVEILLDR;REQCNAERIAK;SPKIHPLQSR;TLTKVLALVKEVPR 4 4.2 0.97905 -1.5322 7.41819 0 5.44566 6.4116 0 0 0 0 0 0 0 0 Q99572 P2RX7_HUMAN P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrial depolarization [GO:0051882]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid transfer to membrane [GO:0006649]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; prostaglandin secretion [GO:0032310]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; protein secretion [GO:0009306]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell apoptotic process [GO:0070231]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900] bleb [GO:0032059]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102] NILPGLNITCTFHKTQNPQCPIFR 1 4 0.88117 -0.17053 0 0 7.45664 9.99873 0 0 0 0 0 0 0 0 Q99575 POP1_HUMAN Ribonucleases P/MRP protein subunit POP1 (hPOP1) POP1 KIAA0061 Homo sapiens (Human) tRNA 5'-leader removal [GO:0001682]; tRNA decay [GO:0016078]; tRNA processing [GO:0008033] extracellular space [GO:0005615]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723] NLLEKYK;QGSLVLYRVNKYPR;SEVPCAPMPKK 3 3.1 0.97865 -2.0957 0 0 0 11.4279 11.0016 9.07674 0 13.4467 13.3526 0 0 0 Q99576 T22D3_HUMAN TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) TSC22D3 DSIPI GILZ Homo sapiens (Human) negative regulation of activation-induced cell death of T cells [GO:0070236]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970] cytosol [GO:0005829]; nucleus [GO:0005634] LVFENLNTDK 1 5 0.060302 0.43691 10.5908 0 0 0 0 0 0 0 0 0 0 0 Q99578 RIT2_HUMAN GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2) RIT2 RIN ROC2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; maintenance of protein location in cell [GO:0032507]; negative regulation of neuron projection development [GO:0010977]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of calcium-mediated signaling [GO:0050848]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of endocytosis [GO:0030100]; small GTPase-mediated signal transduction [GO:0007264] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic tree [GO:0097447]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; semaphorin receptor binding [GO:0030215] VVMLGAGGVGK 1 5.1 0.91588 -0.4315 0 0 0 0 0 0 0 0 0 0 0 10.9163 Q99584 S10AD_HUMAN Protein S100-A13 (S100 calcium-binding protein A13) S100A13 Homo sapiens (Human) mast cell degranulation [GO:0043303]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 alpha production [GO:0032730]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270] DVGSLDEKMK;SLDVNQDSELK 2 21.4 0.96548 -1.2408 0 0 0 0 0 3.92191 0 0 0 4.65632 0 0 Q99590 SCAFB_HUMAN "Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)" SCAF11 CASP11 SFRS2IP SIP1 SRSF2IP Homo sapiens (Human) "mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]" nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA binding [GO:0003723] AVDKVCHSK;RGRKPPLLK;SLEEKNESLTEHPR;SSFAYKDQNENRWQNR;TVCTLNMGDK 5 4 0.95241 -0.74234 5.71345 12.4893 0 4.00144 0 0 6.97361 0 0 0 0 0 Q99592 ZBT18_HUMAN Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171) ZBTB18 RP58 TAZ1 ZNF238 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519] heterochromatin [GO:0000792]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" EASCDESDVGTNDYDMEHSTVK;LKEKATTEADSTK 2 6.7 0.071895 0.42041 0 0 0 0 0 0 7.87117 0 6.87123 0 0 0 Q99593 TBX5_HUMAN T-box transcription factor TBX5 (T-box protein 5) TBX5 Homo sapiens (Human) atrial septum morphogenesis [GO:0060413]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular valve morphogenesis [GO:0003181]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; bundle of His development [GO:0003166]; cardiac left ventricle formation [GO:0003218]; cardiac muscle cell proliferation [GO:0060038]; cell fate specification [GO:0001708]; cell migration involved in coronary vasculogenesis [GO:0060980]; cell-cell signaling [GO:0007267]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; forelimb morphogenesis [GO:0035136]; heart development [GO:0007507]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pattern specification process [GO:0007389]; pericardium development [GO:0060039]; positive regulation of cardiac conduction [GO:1903781]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node development [GO:0003163]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]" EEECSTTDHPYK;FHEVGTEMIITK;VTGLNPK 3 6 0.95531 -0.97763 8.14827 0 8.85431 0 0 0 0 0 0 9.95104 0 0 Q99598 TSNAX_HUMAN Translin-associated protein X (Translin-associated factor X) TSNAX TRAX Homo sapiens (Human) cell differentiation [GO:0030154]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoribonuclease complex [GO:1902555]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] A2A adenosine receptor binding [GO:0031687]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697] DITVESK;QLIFTTEDNGK;TIFLLHR 3 8.6 0.96533 -1.2469 0 0 0 10.7792 0 0 0 0 0 10.3056 0 0 Q99608 NECD_HUMAN Necdin NDN Homo sapiens (Human) axon extension [GO:0048675]; axonal fasciculation [GO:0007413]; central nervous system development [GO:0007417]; genomic imprinting [GO:0071514]; glial cell migration [GO:0008347]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; respiratory system process [GO:0003016]; sensory perception of pain [GO:0019233] cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; gamma-tubulin binding [GO:0043015]; promoter-specific chromatin binding [GO:1990841] ESAVWNVLRILGLRPWKK;KDPQAWPSRYR;LITEEFVQMNYLK 3 13.1 0.73979 0.10461 0 0 0 7.10035 0 0 0 0 8.32935 0 0 0 Q99613 EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) EIF3C EIF3S8 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] DQKDGYRK;GTTEEVCR;LGSLVENNER;LNEILQAR;NAMKIRDVTK;QLTPPEGSSK;SEAPSGESRK 7 7 0.97213 -2.6985 0 0 0 3.21599 8.86808 0 0 0 0 9.62417 11.9318 0 Q99614 TTC1_HUMAN Tetratricopeptide repeat protein 1 (TPR repeat protein 1) TTC1 TPR1 Homo sapiens (Human) protein folding [GO:0006457] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778] unfolded protein binding [GO:0051082] KEMAINDCSK 1 3.4 0.92951 -0.48565 0 0 0 0 0 0 0 0 0 0 0 9.02034 Q99615 DNJC7_HUMAN DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) DNAJC7 TPR2 TTC2 Homo sapiens (Human) chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATPase activator activity [GO:0001671]; heat shock protein binding [GO:0031072] AATLMMLGR;ALEFAPACHR;AQCYMDTEQYEEAVR;EQGNAYYAKK;HSGASAEVQKEEEKK;LDDAIEDCTNAVK;NASEDEIK 7 16.2 0.97448 -3.4973 0 10.1754 11.5289 0 9.7154 0 0 5.75441 11.3716 0 0 0 Q99622 C10_HUMAN Protein C10 C12orf57 C10 Homo sapiens (Human) camera-type eye morphogenesis [GO:0048593]; cognition [GO:0050890]; corpus callosum morphogenesis [GO:0021540]; post-embryonic development [GO:0009791]; psychomotor behavior [GO:0036343]; regulation of skeletal muscle contraction [GO:0014819]; third ventricle development [GO:0021678] cytoplasm [GO:0005737]; nuclear speck [GO:0016607] ASASTQPAALSAEQAK;MLQFVLPVATQIQQEVIK 2 27 0.91659 -0.34968 0 0 0 0 0 0 0 11.6095 0 10.812 0 0 Q99623 PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) PHB2 BAP REA Homo sapiens (Human) antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; estrogen receptor signaling pathway [GO:0030520]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mammary gland epithelial cell proliferation [GO:0033598]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of cytochrome-c oxidase activity [GO:1904959]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062] axon [GO:0030424]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991] amide binding [GO:0033218]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625] EYTAAVEAK;FNASQLITQR;IVQAEGEAEAAK;LGLDYEER;LPAGPRGMGTALKLLLGAGAVAYGVR;QVAQQEAQR;VLPSIVNEVLK 7 28.4 0 10.78 12.1982 12.2131 12.2778 11.3282 10.6474 10.1555 9.78529 10.7454 8.43933 0 8.96431 10.2973 Q99624 S38A3_HUMAN Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) SLC38A3 G17 NAT1 SN1 SNAT3 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; asparagine transport [GO:0006867]; cellular response to potassium ion starvation [GO:0051365]; female pregnancy [GO:0007565]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; histidine transport [GO:0015817]; intracellular amino acid homeostasis [GO:0080144]; L-alanine transport [GO:0015808]; L-asparagine import across plasma membrane [GO:1903811]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transport [GO:1902024]; positive regulation of glutamine transport [GO:2000487]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] "amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine, sodium:proton antiporter activity [GO:0140831]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-histidine, sodium:proton antiporter activity [GO:0140832]; neutral L-amino acid:sodium symporter activity [GO:0005295]" EAPLQTEMVELVPNGK 1 3.2 0.77864 0.034988 0 6.79857 0 0 0 0 0 0 0 0 0 0 Q99626 CDX2_HUMAN Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) CDX2 CDX3 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic pattern specification [GO:0009880]; endosome to lysosome transport [GO:0008333]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intestinal epithelial cell differentiation [GO:0060575]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell differentiation [GO:0048863]; trophectodermal cell differentiation [GO:0001829] chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LELEKEFHYSR 1 3.5 0.92107 -0.44617 11.1692 0 0 0 0 0 0 0 0 0 0 0 Q99633 PRP18_HUMAN Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18) PRPF18 HPRP18 Homo sapiens (Human) generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type post-spliceosomal complex [GO:0071021]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] EEEAYFERCGYK;LNSATQKQTESYLRPLFR;NLPADIK 3 10.8 0.95397 -0.91543 0 0 0 0 0 0 9.96188 0 0 8.75652 0 3.88059 Q99638 RAD9A_HUMAN Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) RAD9A Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231] checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] KCLVTGGNVK;VILRSYHEEEADSTAK 2 6.6 0.95558 -0.8279 0 0 0 5.39825 0 0 0 0 0 0 0 0 Q99640 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) PKMYT1 MYT1 Homo sapiens (Human) G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of G2/MI transition of meiotic cell cycle [GO:0110031]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GSFPSFEPR;LERWHQLQPR;MLERWHQLQPR 3 4.7 0.97476 -2.3945 0 0 0 9.13232 0 10.4131 10.0871 0 12.7252 8.71201 0 0 Q99653 CHP1_HUMAN Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) CHP1 CHP Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; potassium ion transport [GO:0006813]; protein export from nucleus [GO:0006611]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transporter complex [GO:1990351] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; potassium channel regulator activity [GO:0015459]; protein kinase inhibitor activity [GO:0004860]; sodium:proton antiporter activity [GO:0015385] IINAFFPEGEDQVNFRGFMR;LHFAFRLYDLDK;TLAHFRPIEDNEKSK 3 24.1 0.96467 -1.2303 0 0 0 0 0 5.97625 10.3748 0 0 0 0 0 Q99661 KIF2C_HUMAN Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) KIF2C KNSL6 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; postsynaptic cytoskeleton organization [GO:0099188]; regulation of chromosome segregation [GO:0051983]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696] "centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793]; spindle [GO:0005819]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule plus-end binding [GO:0051010] NQPCYRK 1 1 0.91649 -0.41424 0 0 7.99203 0 0 7.40608 0 0 0 7.58271 8.557 0 Q99665 I12R2_HUMAN Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2) IL12RB2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901] APLSGPHINAITEEK;GSILISWNSIPVQEQMGCLLHYRIYWKER;NLTWQKQCK;YPIAEEK 4 7 0.97859 -2.0959 0 0 0 0 9.91615 0 0 0 11.0236 0 0 7.63815 Q99666 RGPD5_HUMAN RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 Homo sapiens (Human) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] AVVSPPK;DLVLKIAELLCK;DVGQWKER;EVVETFANK;KCELSKNSDIEQSSDSK;LPHETSR;LRLLVQHEINTLR;QKSWWDAVCTLIHR;QLCTERQKSWWDAVCTLIHR;VLPLLKIIK;YDVGAIR;YGKMANK;YSLSPSKSYK 13 7.1 0.97254 -2.6793 0 0 0 0 0 0 11.0717 0 0 0 0 9.94707 Q99675 CGRF1_HUMAN Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197) CGRRF1 CGR19 RNF197 Homo sapiens (Human) negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726] endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] ILYQYLLLAQGQFHDLK;YFQQCPMCR 2 7.8 0.74013 0.10522 0 0 10.7313 0 0 0 0 0 0 0 4.11545 0 Q99676 ZN184_HUMAN Zinc finger protein 184 ZNF184 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" IHTGEKPYQCHECGK 1 2 0.87558 -0.12674 0 0 11.3905 0 0 0 0 0 0 0 0 0 Q99678 GPR20_HUMAN G-protein coupled receptor 20 GPR20 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] AKTPSVIYTINLVVTDLLVGLSLPTR;RVRAMQLLLTVLIIFLVCFTPFHAR;SSKGSGR;TNASGLEVPLFHLFAR 4 20.7 0.75804 0.072548 0 0 0 0 0 3.43429 0 9.58888 0 0 9.17582 6.56192 Q99679 GPR21_HUMAN Probable G-protein coupled receptor 21 GPR21 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of multicellular organism growth [GO:0040018] plasma membrane [GO:0005886] trace-amine receptor activity [GO:0001594] ICQQHTKDISER 1 3.4 0.92414 -0.44861 0 0 3.54164 0 0 0 0 0 6.51223 0 0 0 Q99683 M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) MAP3K5 ASK1 MAPKKK5 MEKK5 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cellular response to amino acid starvation [GO:0034198]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cellular response to tumor necrosis factor [GO:0071356]; cellular senescence [GO:0090398]; endothelial cell apoptotic process [GO:0072577]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron apoptotic process [GO:0051402]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; programmed necrotic cell death [GO:0097300]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; IRE1-TRAF2-ASK1 complex [GO:1990604]; protein kinase complex [GO:1902911]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] AIEEKDQEIKHLK;FFEMVNTITEEK;LKTPAWYLKSIVETILIYK;RPQAVIEDAVATSGVSTLSSTVSHDSQSAHR;VGVKLSSLLGKK 5 6.3 0.050435 0.4812 0 0 2.87178 10.778 5.7162 0 0 0 0 10.7245 4.27284 0 Q99684 GFI1_HUMAN Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) GFI1 ZNF163 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; DNA damage response [GO:0006974]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" LLLGGGSYK 1 2.1 0.60746 0.17623 0 0 0 0 0 0 0 0 0 11.2252 0 0 Q99685 MGLL_HUMAN Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) MGLL Homo sapiens (Human) acylglycerol catabolic process [GO:0046464]; arachidonate metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; monoacylglycerol catabolic process [GO:0052651]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] lysophospholipase activity [GO:0004622]; monoacylglycerol lipase activity [GO:0047372]; protein homodimerization activity [GO:0042803] METGPEDPSSMPEESSPR 1 6.4 0.78353 0.019319 0 0 0 0 0 0 0 0 0 0 6.94615 0 Q99689 FEZ1_HUMAN Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1) FEZ1 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; establishment of cell polarity [GO:0030010]; establishment of mitochondrion localization [GO:0051654]; hippocampus development [GO:0021766]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; positive regulation of anterograde axonal transport of mitochondrion [GO:0061881]; positive regulation of neuron projection development [GO:0010976] axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] gamma-tubulin binding [GO:0043015]; protein kinase C binding [GO:0005080] QYLNTVIPYEKK;RDELEFEK 2 5.1 0.72647 0.12351 8.4417 11.7433 8.44572 6.27969 0 0 0 0 0 9.14106 0 0 Q99697 PITX2_HUMAN Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) PITX2 ARP1 RGS RIEG RIEG1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; deltoid tuberosity development [GO:0035993]; determination of left/right symmetry [GO:0007368]; embryonic heart tube left/right pattern formation [GO:0060971]; hair cell differentiation [GO:0035315]; iris morphogenesis [GO:0061072]; left/right axis specification [GO:0070986]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spleen development [GO:0048536] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" EEIAVWTNLTEARVR;THFTSQQLQELEATFQRNRYPDMSTR;VEFTDSPESR 3 16.1 0.93392 -0.5051 0 0 0 8.78473 0 2.24059 7.71005 8.12045 0 5.77149 0 11.3436 Q99698 LYST_HUMAN Lysosomal-trafficking regulator (Beige homolog) LYST CHS CHS1 Homo sapiens (Human) defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; leukocyte chemotaxis [GO:0030595]; mast cell secretory granule organization [GO:0033364]; melanosome organization [GO:0032438]; natural killer cell mediated cytotoxicity [GO:0042267]; phagocytosis [GO:0006909]; pigmentation [GO:0043473]; protein localization [GO:0008104]; protein transport [GO:0015031] cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] protein kinase binding [GO:0019901] ALETMIK;FQGILPSSGSEDLLWK;ISIWVSGQR;LFILIHR;LGGFRVCHK;LIFMIIQKLFRSHK;MSQENPSQATETELAQR;QLFHMAHVSRPGAK;QLFHMAHVSRPGAKLNIEGELPAAVGLLVQFAFR;RTMKEDLLSLAIK;RTQNMAVALQLR;SEDDSPGDESCPR;SVIIPLLHAFKLPALK 13 4.4 0.97688 -4.8895 11.1422 13.3397 12.3153 7.58113 8.25489 0 8.61743 8.59447 9.93611 0 10.2716 6.9465 Q99706 KI2L4_HUMAN Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) KIR2DL4 CD158D KIR103AS Homo sapiens (Human) cellular defense response [GO:0006968]; immune response-regulating signaling pathway [GO:0002764]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of cellular senescence [GO:2000774]; positive regulation of natural killer cell cytokine production [GO:0002729]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886] MHC class Ib receptor activity [GO:0032394]; transmembrane signaling receptor activity [GO:0004888] ITGPSQR;TGIARHLHAVIR 2 5 0.96533 -1.157 0 0 0 0 0 0 0 0 8.96872 0 0 0 Q99707 METH_HUMAN Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) MTR Homo sapiens (Human) axon regeneration [GO:0031103]; cellular response to nitric oxide [GO:0071732]; cobalamin metabolic process [GO:0009235]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; nervous system development [GO:0007399]; response to axon injury [GO:0048678]; sulfur amino acid metabolic process [GO:0000096]; tetrahydrofolate metabolic process [GO:0046653] cytosol [GO:0005829] cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270] CIVNSISLKEGEDDFLEKAR;ELLQLCEDLIWNK;GMEAIREAMHGVFLYHAIK;LEYALVKVIK 4 5.1 0.91271 -0.38957 0 10.533 0 0 0 0 0 9.22624 0 0 0 12.3947 Q99708 CTIP_HUMAN DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) RBBP8 CTIP Homo sapiens (Human) blastocyst hatching [GO:0001835]; cell division [GO:0051301]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous recombination [GO:0035825]; meiotic cell cycle [GO:0051321]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription by RNA polymerase II [GO:0006357] BRCA1-C complex [GO:0070533]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; transcription repressor complex [GO:0017053] damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transcription corepressor activity [GO:0003714] DLWTKLK;IFGKLVFLPLRLVWK;KASDGNCTLPK;LITELMNERNTLQEENKK;NTLQEENKKLSEQLQQK;SLGGRTSK;VLEDRLR 7 8.5 0.97498 -3.0743 0 10.3235 10.3837 9.17814 7.0798 0 0 0 10.8563 0 5.81757 0 Q99714 HCD2_HUMAN 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2 Homo sapiens (Human) androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; brexanolone metabolic process [GO:0062173]; C21-steroid hormone metabolic process [GO:0008207]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550]; lipid metabolic process [GO:0006629]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrion organization [GO:0007005]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; tRNA methyltransferase complex [GO:0043527] "17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity [GO:0047015]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase activity [GO:0008709]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106282]; RNA binding [GO:0003723]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)+] activity [GO:0030283]; tRNA binding [GO:0000049]; ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106283]" GGIVGMTLPIAR;LVGQGASAVLLDLPNSGGEAQAK 2 13.4 0 3.9618 0 0 0 0 0 0 0 0 0 8.52924 0 0 Q99715 COCA1_HUMAN Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987] collagen type XII trimer [GO:0005595]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AATSYRLK;EVTTPPNQRRR;GAPRNLK;GDRGDIASQNMMRAVAR;GGNTRTGKALTFIK;IIYSPTVGDPIDEYTTVPGR;ISFELTQSICLR;NLKTSDPTMSSFR;QQNFRTQAGMRPR;TLSFFNKDTR;VGFPKVAIIITDGK;VTWKPAPGK;WDPASGRVQKYR 13 5.2 0.97473 -4.0717 9.52532 3.10553 11.9476 0 0 10.9029 10.0532 12.29 11.0378 13.8489 14.0481 10.6985 Q99717 SMAD5_HUMAN Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) SMAD5 MADH5 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle contraction [GO:0060048]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; Mullerian duct regression [GO:0001880]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of gene expression [GO:0010629]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; stem cell differentiation [GO:0048863]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141] "DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]" ALSSPGQPSK;AVDALVK;HWCSIVYYELNNR 3 6.5 0.95429 -0.91234 11.3877 0 0 0 0 0 0 8.75251 0 0 0 0 Q99719 SEPT5_HUMAN Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) SEPTIN5 PNUTL1 SEPT5 Homo sapiens (Human) adult behavior [GO:0030534]; cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; social behavior [GO:0035176]; synaptic vesicle targeting [GO:0016080] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] LLSAEERISQTVEILK 1 4.3 0.81165 -0.012925 0 0 0 0 0 0 0 12.5818 0 0 0 0 Q99727 TIMP4_HUMAN Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4) TIMP4 Homo sapiens (Human) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191] DVQYIYTPFDSSLCGVK 1 7.6 0.78491 0.029144 0 0 0 0 3.92001 0 0 0 0 0 0 0 Q99728 BARD1_HUMAN BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) BARD1 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of mRNA 3'-end processing [GO:0031441]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of phosphorylation [GO:0042325]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue homeostasis [GO:0001894] BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] histone H2AK127 ubiquitin ligase activity [GO:0140863]; histone H2AK129 ubiquitin ligase activity [GO:0140864]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842] MPDNRQPRNR;NSIKMWFSPR;TLAEINQK;VGGTSGRK 4 4.6 0.96788 -1.3202 11.2456 0 0 0 0 0 0 0 0 7.35878 8.94451 0 Q99729 ROAA_HUMAN Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) HNRNPAB ABBP1 HNRPAB Homo sapiens (Human) "cellular response to amino acid stimulus [GO:0071230]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468]; regulation of intracellular mRNA localization [GO:1904580]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mRNA editing complex [GO:0045293]; neuronal ribonucleoprotein granule [GO:0071598]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575] mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837] DYFTKFGEVVDCTIK;EVYQQQQYGSGGR;GRGWTGAAAGAGGATAAPPSGNQNGAEGDQINASK 3 19 0.81301 -0.0079494 0 4.34908 0 0 0 0 0 0 0 0 0 0 Q99729 ROAA_HUMAN Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) HNRNPAB ABBP1 HNRPAB Homo sapiens (Human) "cellular response to amino acid stimulus [GO:0071230]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468]; regulation of intracellular mRNA localization [GO:1904580]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mRNA editing complex [GO:0045293]; neuronal ribonucleoprotein granule [GO:0071598]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575] mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837] DYFTKFGEVVDCTIK;EVYQQQQYGSGGR;IFVGGLNPEATEEK 3 14.7 0 2.7612 0 0 0 0 0 0 0 0 9.73122 0 10.0021 0 Q99733 NP1L4_HUMAN Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) NAP1L4 NAP2 Homo sapiens (Human) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] LTDQVMQNPR;MKSEPDKADPFSFEGPEIVDCDGCTIDWK 2 10.4 0.8086 0.0065892 0 9.04979 10.1543 0 0 0 0 0 0 0 6.85848 0 Q99735 MGST2_HUMAN Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II) MGST2 GST2 Homo sapiens (Human) glutathione biosynthetic process [GO:0006750]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; membrane lipid catabolic process [GO:0046466]; positive regulation of inflammatory response [GO:0050729]; response to lipopolysaccharide [GO:0032496] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464] HLYFWGYSEAAKK 1 8.8 0.67447 0.16677 0 0 0 0 0 0 0 0 0 0 8.37886 0 Q99741 CDC6_HUMAN Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) CDC6 CDC18L Homo sapiens (Human) cell division [GO:0051301]; cellular response to angiotensin [GO:1904385]; cellular response to vasopressin [GO:1904117]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of cytokinesis [GO:0032467]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; traversing start control point of mitotic cell cycle [GO:0007089] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase binding [GO:0019900]; nucleotide binding [GO:0000166] LTKVFFKIEEK;TIMLNCMSLR 2 3.8 0.85026 -0.075603 0 6.62054 0 0 0 0 0 0 0 0 0 9.02578 Q99742 NPAS1_HUMAN Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) NPAS1 BHLHE11 MOP5 PASD5 Homo sapiens (Human) central nervous system development [GO:0007417]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; startle response [GO:0001964] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LSLGLTILACESR 1 2.2 0.8769 -0.12596 0 0 0 9.94555 0 0 0 0 0 0 0 0 Q99747 SNAG_HUMAN Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) NAPG SNAPG Homo sapiens (Human) intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; SNARE complex [GO:0031201] soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905] YMDNDYAK 1 2.6 0.91524 -0.39033 0 0 0 0 0 3.37823 0 0 0 0 0 6.43808 Q99755 PI51A_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) PIP5K1A Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phospholipid biosynthetic process [GO:0008654]; protein localization to plasma membrane [GO:0072659]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165] cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol kinase activity [GO:0052742] TTSSALK 1 1.2 0.81455 -0.0014148 0 0 0 0 0 0 0 11.5834 0 0 0 0 Q99757 THIOM_HUMAN "Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)" TXN2 TRX2 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730] peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein-containing complex binding [GO:0044877]; protein-disulfide reductase activity [GO:0015035] LLLRRFLASVISR 1 7.8 0.86549 -0.092385 0 0 0 0 5.5995 0 0 0 0 0 0 0 Q99758 ABCA3_HUMAN Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form] ABCA3 ABC3 Homo sapiens (Human) lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019] ASVEGGGFNER;GLLLEPHANK 2 1.2 0.92966 -0.47405 0 0 0 0 0 0 0 0 0 3.11977 0 10.8841 Q99759 M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) MAP3K3 MAPKKK3 MEKK3 Homo sapiens (Human) blood vessel development [GO:0001568]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ILLLSQDR;TLTIFMEYMPGGSVK 2 3.7 0.9415 -0.61159 0 0 0 0 0 0 0 0 5.8481 0 0 0 Q99766 ATP5S_HUMAN "ATP synthase subunit s, mitochondrial (ATP synthase-coupling factor B) (FB) (Distal membrane arm assembly complex 2-like protein) (Mitochondrial ATP synthase regulatory component factor B)" DMAC2L ATP5S ATPW Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; proton transmembrane transport [GO:1902600] "cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078] AASEWLLR 1 4 0.92892 -0.46114 0 0 0 0 0 0 0 0 0 0 10.3247 0 Q99784 NOE1_HUMAN Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) OLFM1 NOE1 NOEL1 Homo sapiens (Human) atrioventricular valve formation [GO:0003190]; cardiac epithelial to mesenchymal transition [GO:0060317]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuronal signal transduction [GO:0023041]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; regulation of axon extension [GO:0030516]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165] axon [GO:0030424]; axonal growth cone [GO:0044295]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; synapse [GO:0045202] LSAAGGGTLDR;TQRDLQYVEK 2 4.3 0.95532 -0.87651 0 0 0 10.365 0 0 0 0 9.71342 0 0 0 Q99797 MIPEP_HUMAN Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) MIPEP MIP Homo sapiens (Human) peptide metabolic process [GO:0006518]; protein processing involved in protein targeting to mitochondrion [GO:0006627] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ALQGTIAK;LSDKLSER;SIGTMVEK;VADLADFVK 4 4.6 0.97725 -2.2266 12.5544 0 0 0 0 0 0 0 0 0 0 9.51211 Q99798 ACON_HUMAN "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" ACO2 Homo sapiens (Human) citrate metabolic process [GO:0006101]; generation of precursor metabolites and energy [GO:0006091]; isocitrate metabolic process [GO:0006102]; liver development [GO:0001889]; response to isolation stress [GO:0035900]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron ion binding [GO:0005506]" DGYAQILR;IVYGHLDDPASQEIERGKSYLR;LTGSLSGWSSPK;NAVTQEFGPVPDTAR;NTIVTSYNR;SQFTITPGSEQIR 6 10.1 0.92179 -0.44558 0 0 0 0 0 0 10.8256 10.7047 10.6869 10.0349 12.2397 0 Q99801 NKX31_HUMAN Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) NKX3-1 NKX3.1 NKX3A Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; branching involved in prostate gland morphogenesis [GO:0060442]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; dorsal aorta development [GO:0035907]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; heart development [GO:0007507]; male gonad development [GO:0008584]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharyngeal system development [GO:0060037]; positive regulation of androgen secretion [GO:2000836]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to testosterone [GO:0033574]; salivary gland development [GO:0007431]; somitogenesis [GO:0001756] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] "cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; MADS box domain binding [GO:0097162]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription regulator inhibitor activity [GO:0140416]" HSSLPALKEEAFSR 1 6 0.92136 -0.44127 0 0 9.29147 0 0 0 0 0 0 0 0 0 Q99805 TM9S2_HUMAN Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; protein localization to membrane [GO:0072657]; regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010908] endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] AEIELFVNR;LLLLSLLLLGAVPGPRR;LVHGDIFRPPRK 3 5.7 0.84085 -0.044534 0 0 0 0 0 0 0 0 8.74325 10.9241 0 6.39577 Q99807 COQ7_HUMAN "5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)" COQ7 Homo sapiens (Human) determination of adult lifespan [GO:0008340]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of reactive oxygen species metabolic process [GO:2000377]; ubiquinone biosynthetic process [GO:0006744] chromosome [GO:0005694]; extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ubiquinone biosynthesis complex [GO:0110142] "3-demethoxyubiquinol 3-hydroxylase activity [GO:0008682]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" SLSAYGR 1 3.2 0.81192 -0.012091 0 0 10.0052 0 0 0 0 0 0 0 8.54894 0 Q99808 S29A1_HUMAN "Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)" SLC29A1 ENT1 Homo sapiens (Human) adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cytidine transport [GO:0015861]; excitatory postsynaptic potential [GO:0060079]; guanine transmembrane transport [GO:1903716]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; lactation [GO:0007595]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleobase transmembrane transport [GO:1904082]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213] ILGSLVAILLVFLITAILVK;IPQSVRILGSLVAILLVFLITAILVK;WLPSLVLARLVFVPLLLLCNIKPR 3 11 0.74584 0.095862 7.80729 8.71552 9.21284 0 0 4.65358 0 0 0 0 0 8.45022 Q99816 TS101_HUMAN Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) TSG101 Homo sapiens (Human) autophagosome maturation [GO:0097352]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein modification process [GO:0036211]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790] TAGLSDLY 1 2.1 0.78262 0.025644 0 0 9.22224 0 0 0 0 0 0 0 0 0 Q99819 GDIR3_HUMAN Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma) ARHGDIG Homo sapiens (Human) blastocyst hatching [GO:0001835]; negative regulation of cell adhesion [GO:0007162]; regulation of protein localization [GO:0032880]; Rho protein signal transduction [GO:0007266] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094] SLLEIRQLDPDDRSLAK 1 7.6 0.95508 -0.96911 0 0 0 0 0 0 0 11.148 0 0 0 0 Q99828 CIB1_HUMAN Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28) CIB1 CIB KIP PRKDCIP Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; endomitotic cell cycle [GO:0007113]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of neuron projection development [GO:0010977]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; platelet formation [GO:0030220]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of cell division [GO:0051302]; regulation of cell population proliferation [GO:0042127]; response to ischemia [GO:0002931]; spermatid development [GO:0007286]; thrombopoietin-mediated signaling pathway [GO:0038163] apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell periphery [GO:0071944]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; calcium-dependent protein kinase inhibitor activity [GO:0008427]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-membrane adaptor activity [GO:0043495]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] LSASEMK;MGGSGSR 2 7.3 0.882 -0.15883 0 6.81941 10.2696 0 8.56064 10.5386 10.5179 10.2003 10.1449 10.0835 10.3232 0 Q99829 CPNE1_HUMAN Copine-1 (Chromobindin 17) (Copine I) CPNE1 CPN1 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; vesicle-mediated transport [GO:0016192] azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786] DFLGKSDPFLEFFRQGDGK;LYGPTNFAPIINHVAR;WHLVYRSEVIKNNLNPTWK 3 10.1 0.082409 0.39411 0 12.7406 0 0 0 0 6.77334 13.0294 0 0 0 0 Q99832 TCPH_HUMAN "T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]" CCT7 CCTH NIP7-1 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] ALEIIPR;ATISNDGATILK;GGAEQFMEETER;LPIGDVATQYFADR;MMPTPVILLK;SQDAEVGDGTTSVTLLAAEFLK;STVDAPTAAGR;TATQLAVNK;TATQLAVNKIK;TFSYAGFEMQPK;TIPGKQQLLIGAYAK;TLVDIAK 12 24.5 0 35.966 13.7244 13.6627 13.6763 10.1464 8.16962 7.92707 12.2292 11.6571 12.426 13.2203 12.9008 9.2949 Q99835 SMO_HUMAN Protein smoothened (Protein Gx) SMO SMOH Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system development [GO:0007417]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell proliferation [GO:0050673]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; pattern specification process [GO:0007389]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of somatic stem cell population maintenance [GO:1904672]; response to inositol [GO:1902140]; skeletal muscle fiber development [GO:0048741]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371] 9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; ciliary membrane [GO:0060170]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; plasma membrane [GO:0005886] cAMP-dependent protein kinase inhibitor activity [GO:0004862]; G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]; patched binding [GO:0005113]; protein kinase A catalytic subunit binding [GO:0034236]; protein sequestering activity [GO:0140311] GPELPLLGLLLLLLLGDPGR;TLCQATR 2 3.4 0.94183 -0.60523 0 0 0 0 4.05554 0 0 0 0 0 0 0 Q99848 EBP2_HUMAN Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) EBNA1BP2 EBP2 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] "chromosome [GO:0005694]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] ELQDAFSR;LDFLEGDQKPLAQR;LQTKQAAMER 3 10.5 0.97848 -1.9781 0 0 0 0 0 10.8354 0 0 0 0 0 0 Q99873 ANM1_HUMAN Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) PRMT1 HMT2 HRMT1L2 IR1B4 Homo sapiens (Human) cardiac muscle tissue development [GO:0048738]; cell surface receptor signaling pathway [GO:0007166]; cellular response to methionine [GO:0061431]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; in utero embryonic development [GO:0001701]; negative regulation of JNK cascade [GO:0046329]; negative regulation of megakaryocyte differentiation [GO:0045653]; neuron projection development [GO:0031175]; peptidyl-arginine methylation [GO:0018216]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of BMP signaling pathway [GO:0030510]; regulation of DNA-templated transcription [GO:0006355]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]; viral protein processing [GO:0019082] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme binding [GO:0019899]; GATOR1 complex binding [GO:0106080]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; mitogen-activated protein kinase p38 binding [GO:0048273]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; RNA binding [GO:0003723]; S-adenosyl-L-methionine binding [GO:1904047] DEVRTLTYRNSMFHNR;NDYVHALVAYFNIEFTRCHK;RTGFSTSPESPYTHWK 3 14 0.61026 0.17494 0 0 0 0 0 0 0 0 0 10.2317 0 8.73799 Q99877 H2B1N_HUMAN Histone H2B type 1-N (Histone H2B.d) (H2B/d) H2BC15 H2BFD HIST1H2BN Homo sapiens (Human) nucleosome assembly [GO:0006334] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AMGIMNSFVNDIFER;EIQTAVR;ESYSVYVYK;HAVSEGTK;IAGEASR;KESYSVYVYK;LAHYNKR;LLLPGELAK;PEPSKSAPAPK;QVHPDTGISSK 10 67.5 0 103.64 18.6116 18.6776 18.3755 13.4033 15.4389 15.2764 17.7213 15.7986 14.6433 14.7855 14.0693 14.1443 Q99880 H2B1L_HUMAN Histone H2B type 1-L (Histone H2B.c) (H2B/c) H2BC13 H2BFC HIST1H2BL Homo sapiens (Human) nucleosome assembly [GO:0006334] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AMGIMNSFVNDIFER;EIQTAVR;ESYSVYVYK;HAVSEGTK;IASEASR;KESYSVYVYK;LAHYNKR;LLLPGELAK;QVHPDTGISSK 9 58.7 0.91132 -0.32734 0 8.48788 0 0 0 0 0 0 0 0 0 0 Q99909 SSX3_HUMAN Protein SSX3 (Cancer/testis antigen 5.3) (CT5.3) SSX3 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] INMISGPK;IVYVYMK;IVYVYMKR;LGFKAILPSFMRNK 4 16 0.976 -2.2585 0 0 0 0 0 0 12.5824 0 0 0 0 0 Q99928 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3) GABRG3 Homo sapiens (Human) "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DCQSFFCCYEECK;VFFPTSFLLFNLVYWVGYLYL 2 7.3 0.87569 -0.12155 0 8.24479 0 0 0 7.1374 0 0 0 0 8.77304 0 Q99932 SPAG8_HUMAN Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84) SPAG8 Homo sapiens (Human) cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; spindle [GO:0005819] microtubule binding [GO:0008017] APQLPVCEGD 1 2.3 0.80406 0.012867 3.54077 0 0 0 0 0 0 0 0 0 0 0 Q99933 BAG1_HUMAN BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) BAG1 HAP Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of apoptotic process [GO:0043066]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] adenyl-nucleotide exchange factor activity [GO:0000774]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] GAAAGAR;KVQAFLAECDTVEQNICQETER;NSPQEEVELK 3 11.3 0.228 0.30289 0 0 0 5.72909 0 0 0 0 0 9.71194 6.45474 0 Q99935 PROL1_HUMAN Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin] OPRPN BPLP PROL1 Homo sapiens (Human) regulation of sensory perception of pain [GO:0051930] extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414] LNSPLSLPFVPGR 1 5.2 0.87627 -0.12137 0 0 14.0271 0 11.1523 0 0 0 0 0 0 0 Q99941 ATF6B_HUMAN Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] ATF6B CREBL1 G13 Homo sapiens (Human) ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" HFNRTESLR;LGSGNRK 2 2.3 0.9741 -1.4234 0 0 0 0 0 0 0 0 0 10.0611 0 0 Q99952 PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) PTPN18 BDP1 Homo sapiens (Human) blastocyst formation [GO:0001825]; negative regulation of ERBB signaling pathway [GO:1901185]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" VILMACREIENGR 1 2.8 0.94664 -0.65802 0 11.8355 0 0 0 0 0 0 0 0 0 0 Q99952 PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) PTPN18 BDP1 Homo sapiens (Human) blastocyst formation [GO:0001825]; negative regulation of ERBB signaling pathway [GO:1901185]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" EGAVLAGEFSK 1 3.1 0.89613 -0.23763 0 9.67009 0 0 0 0 0 0 0 0 0 0 Q99956 DUS9_HUMAN Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) DUSP9 MKP4 Homo sapiens (Human) ERK1 and ERK2 cascade [GO:0070371]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" SCLWLRRELSPPRPR 1 3.9 0.85163 -0.079372 0 0 0 0 0 0 0 0 0 0 0 7.39154 Q99958 FOXC2_HUMAN Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) FOXC2 FKHL14 MFH1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; embryonic viscerocranium morphogenesis [GO:0048703]; glomerular endothelium development [GO:0072011]; glomerular mesangial cell development [GO:0072144]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; paraxial mesodermal cell fate commitment [GO:0048343]; podocyte differentiation [GO:0072112]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular wound healing [GO:0035470]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ENKQGWQNSIRHNLSLNECFVK 1 4.4 0.55479 0.18299 0 0 0 8.84884 0 0 0 0 0 8.44547 0 0 Q99959 PKP2_HUMAN Plakophilin-2 PKP2 Homo sapiens (Human) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; desmosome assembly [GO:0002159]; desmosome organization [GO:0002934]; heart development [GO:0007507]; intermediate filament bundle assembly [GO:0045110]; maintenance of animal organ identity [GO:0048496]; maintenance of protein localization at cell tip [GO:0099017]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of cell-substrate adhesion [GO:0010810]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; ventricular cardiac muscle cell action potential [GO:0086005]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell tip [GO:0051286]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; DNA binding [GO:0003677]; intermediate filament binding [GO:0019215]; molecular adaptor activity [GO:0060090]; protein kinase C binding [GO:0005080]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] AAPGAPAEYGYIR;GILKLLQLLK;IQEQVQQTLAR;ISAAATFIQHECFQK;MAAPGAPAEYGYIR;NLSLQNEIAK;VNQLRGILKLLQLLK 7 7.4 0.068966 0.42337 0 7.91433 0 0 4.06987 12.0609 0 3.52469 0 9.47917 0 4.47625 Q99961 SH3G1_HUMAN Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) SH3GL1 CNSA1 SH3D2B Homo sapiens (Human) central nervous system development [GO:0007417]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; podosome [GO:0002102]; presynapse [GO:0098793] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] ELGGESNFGDALLDAGESMK;IPDEELR 2 7.3 0.78558 0.029565 0 0 0 0 0 0 0 0 0 6.92529 0 0 Q99962 SH3G2_HUMAN Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) SH3GL2 CNSA2 SH3D2A Homo sapiens (Human) cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system development [GO:0007417]; dendrite extension [GO:0097484]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron projection development [GO:0031175]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] cell projection [GO:0042995]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793] identical protein binding [GO:0042802]; lipid binding [GO:0008289] DLREIQHHLK;IPDEELR 2 4.8 0.95567 -0.82707 8.60051 0 0 0 0 0 0 0 0 0 9.23991 0 Q99963 SH3G3_HUMAN Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) SH3GL3 CNSA3 SH3D2C Homo sapiens (Human) central nervous system development [GO:0007417]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; positive regulation of neuron differentiation [GO:0045666]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] "acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic endosome [GO:0098845]; presynapse [GO:0098793]" identical protein binding [GO:0042802]; lipid binding [GO:0008289] DLKEIGHHLKK;LDYDYKK 2 5.2 0.95365 -0.92608 0 0 0 0 0 0 5.47755 0 0 0 0 0 Q99965 ADAM2_HUMAN Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta) ADAM2 FTNB Homo sapiens (Human) adult behavior [GO:0030534]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; gene expression [GO:0010467]; male gonad development [GO:0008584]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; visual learning [GO:0008542] cell surface [GO:0009986]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] KADVSLYNEK 1 1.4 0.73574 0.11152 0 0 0 0 0 0 11.1324 0 0 0 0 0 Q99966 CITE1_HUMAN Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) CITED1 MSG1 Homo sapiens (Human) apoptotic process [GO:0006915]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; mesenchymal to epithelial transition [GO:0060231]; metanephros development [GO:0001656]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; pigmentation [GO:0043473]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to interleukin-11 [GO:0071105]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-6 [GO:0070741]; response to interleukin-9 [GO:0071104]; response to lipopolysaccharide [GO:0032496]; response to parathyroid hormone [GO:0071107]; response to transforming growth factor beta [GO:0071559]; response to type II interferon [GO:0034341]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713] EDANQEMSSVAYSNLAVKDR 1 10.4 0.81733 -0.01737 0 0 0 0 0 0 0 0 0 0 6.10293 0 Q99969 RARR2_HUMAN Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein) RARRES2 TIG2 Homo sapiens (Human) antifungal humoral response [GO:0019732]; antifungal innate immune response [GO:0061760]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of protein phosphorylation [GO:0001934]; regulation of lipid catabolic process [GO:0050994]; retinoid metabolic process [GO:0001523] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] signaling receptor binding [GO:0005102] EAEEHQETQCLR;LEFKLQQTSCRK;LQQTSCRK;VLGRLVHCPIETQVLR 4 24.5 0.97613 -2.3381 8.82063 0 0 8.64972 0 0 0 0 5.64469 0 4.94434 0 Q99972 MYOC_HUMAN "Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]" MYOC GLC1A TIGR Homo sapiens (Human) bone development [GO:0060348]; clustering of voltage-gated sodium channels [GO:0045162]; ERBB2-ERBB3 signaling pathway [GO:0038133]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of JNK cascade [GO:0046330]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; skeletal muscle hypertrophy [GO:0014734] cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; node of Ranvier [GO:0033268]; rough endoplasmic reticulum [GO:0005791] fibronectin binding [GO:0001968]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; myosin light chain binding [GO:0032027]; receptor tyrosine kinase binding [GO:0030971] LDLEATK;LDLEATKAR 2 1.8 0.95536 -0.87291 0 0 0 0 0 0 0 11.8808 0 0 0 0 Q99973 TEP1_HUMAN Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) telomere maintenance via recombination [GO:0000722] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; ribonucleoprotein complex [GO:1990904]; telomerase holoenzyme complex [GO:0005697]" ATP binding [GO:0005524]; enzyme binding [GO:0019899]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034] CSPEGEWTTGNMWQK;DRSLLCWDVRTPK;FLCHLSRQQLR;GQLKEPGALPSTYR;ISEWQVK;LPFMAMLRNLCNLLRVGISSR;LQHAKSVIHSRQFPFR;LSRPETWER;SLLCWDVR;WGVTEEETRR 10 4.4 0.97566 -4.3683 0 9.33526 4.99318 0 8.15937 8.06377 12.9481 0 0 6.79559 7.54767 0 Q99983 OMD_HUMAN Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) OMD SLRR2C UNQ190/PRO216 Homo sapiens (Human) cell adhesion [GO:0007155] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] QNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNR;STNGQTIQLK 2 10.7 0.95545 -0.80709 0 0 0 0 0 0 11.0965 0 11.0857 0 0 0 Q99985 SEM3C_HUMAN Semaphorin-3C (Semaphorin-E) (Sema E) SEMA3C SEMAE Homo sapiens (Human) axon guidance [GO:0007411]; blood vessel remodeling [GO:0001974]; cardiac endothelial to mesenchymal transition [GO:0140074]; cardiac right ventricle morphogenesis [GO:0003215]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; immune response [GO:0006955]; limb bud formation [GO:0060174]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; neural tube development [GO:0021915]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cell migration [GO:0030335]; post-embryonic development [GO:0009791]; pulmonary myocardium development [GO:0003350]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] VEECKMAGK;VNAADGR 2 2.1 0.98048 -1.6087 0 11.292 0 0 0 0 0 0 0 0 0 10.5089 Q99986 VRK1_HUMAN Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) VRK1 Homo sapiens (Human) Cajal body organization [GO:0030576]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; Golgi disassembly [GO:0090166]; mitotic nuclear membrane disassembly [GO:0007077]; neuron projection development [GO:0031175]; positive regulation of protein localization to chromatin [GO:0120187]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of neuron migration [GO:2001222]; signal transduction [GO:0007165] Cajal body [GO:0015030]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone binding [GO:0042393]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AX kinase activity [GO:0141003]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; nucleosomal DNA binding [GO:0031492]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FGSDLQKIYEANAK;FMIMDRFGSDLQKIYEANAK;LKYLGVPK 3 7.1 0.98031 -1.8637 0 10.6832 0 0 3.62504 0 0 0 0 0 0 0 Q99988 GDF15_HUMAN Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) GDF15 MIC1 PDF PLAB PTGFB Homo sapiens (Human) cell-cell signaling [GO:0007267]; cellular response to chemical stress [GO:0062197]; GDF15-GFRAL signaling pathway [GO:0160144]; negative regulation of appetite [GO:0032099]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; response to metformin [GO:1901558]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803] ILTPEVR 1 2.3 0.87095 -0.10216 0 9.99308 9.63633 0 0 0 0 0 0 0 0 0 Q99996 AKAP9_HUMAN A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; maintenance of centrosome location [GO:0051661]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of Golgi organization [GO:1903358]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165] centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic branch [GO:0044307]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; potassium channel complex [GO:0034705]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; potassium channel regulator activity [GO:0015459]; protein kinase A regulatory subunit binding [GO:0034237]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] AEGVIDGYADEKTLFER;ANNRLLKILLEVVK;DCVLTISEEMFSK;DIQERNEEIEKLEFR;DKEELEDLKFSLESQK;IREMSSTLDRER;IVELLNETEK;LEALQRR;LEVQCQAEK;LLEGNEKKQR;LQMEAQR;LQVLPQKASER;LSDLSEQLKQK;LTTADKLLGELQEQIVQK;RNHKDSQFETDIVQR;SLENQTYFK;SLENQTYFKSFEENGK;SLSTVEDLK;TQLLFSHEEELSK;VIEEKNELIR;VTGSVSININR 21 6.2 0.97817 -6.313 8.55129 10.9115 11.7259 6.67539 0 10.534 10.2656 12.2836 11.618 4.90338 10.3766 10.271 Q9BPU6 DPYL5_HUMAN Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) DPYSL5 CRMP5 ULIP6 Homo sapiens (Human) axon guidance [GO:0007411]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; signal transduction [GO:0007165] cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; protein-containing complex [GO:0032991] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]" DIGAIAR;ETSLVDAYEK;MLANSASVRILIKGGK 3 5.9 0.96804 -1.3251 14.5019 14.0525 15.4116 11.9351 12.1471 11.2566 8.61839 0 8.65413 13.8022 13.7939 13.7288 Q9BPV8 P2Y13_HUMAN P2Y purinoceptor 13 (P2Y13) (G-protein coupled receptor 86) (G-protein coupled receptor 94) P2RY13 GPR86 GPR94 FKSG77 Homo sapiens (Human) cellular response to organic cyclic compound [GO:0071407]; G protein-coupled receptor signaling pathway [GO:0007186] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028] IIRPLRNIFLKKPVFAK;LPCMQGRK;NTTVMQGFNRSERCPR;WHQMVNNICQFIFWTVFILMLVFYVVIAKK 4 21.3 0.95932 -1.0422 12.3593 0 0 0 10.5554 9.93278 0 11.5626 0 0 0 0 Q9BPW4 APOL4_HUMAN Apolipoprotein L4 (Apolipoprotein L-IV) (ApoL-IV) APOL4 Homo sapiens (Human) lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] lipid binding [GO:0008289] EGAALLK 1 2 0.68151 0.16512 0 0 9.38053 0 0 0 0 0 0 0 0 0 Q9BPW8 NIPS1_HUMAN Protein NipSnap homolog 1 (NipSnap1) NIPSNAP1 Homo sapiens (Human) mitophagy [GO:0000423]; sensory perception of pain [GO:0019233] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synaptic membrane [GO:0097060] protein-macromolecule adaptor activity [GO:0030674] FSGGYPALMDCMNK 1 4.9 0.68509 0.16262 0 3.40149 0 0 0 0 0 0 0 0 0 0 Q9BPW9 DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE) DHRS9 RDH15 SDR9C4 UNQ835/PRO1773 Homo sapiens (Human) 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; racemase and epimerase activity [GO:0016854]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" AFGVHVSCIERLDKLK 1 5.7 0.4384 0.1946 0 0 0 0 0 8.61875 0 0 0 0 0 0 Q9BPW9 DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE) DHRS9 RDH15 SDR9C4 UNQ835/PRO1773 Homo sapiens (Human) 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; racemase and epimerase activity [GO:0016854]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" LDPPQPAHWR 1 2.6 0.81206 -0.013993 0 0 0 0 0 0 0 0 0 0 11.0431 0 Q9BPX3 CND3_HUMAN Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) NCAPG CAPG NYMEL3 Homo sapiens (Human) cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]" CQTAEADSESDHEVPEPESEMK;KLLAVLQEILILPTIPISLVSFLVER;LLSDFLDSEVSELR;YVMVVYKR 4 6.9 0.95133 -0.69558 0 0 0 0 0 0 0 8.84496 0 9.46076 9.60211 0 Q9BPX6 MICU1_HUMAN "Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4)" MICU1 CALC CBARA1 Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; cellular response to calcium ion [GO:0071277]; cellular response to calcium ion starvation [GO:0072732]; defense response [GO:0006952]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of cristae formation [GO:1903852]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] calcium channel complex [GO:0034704]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel inhibitor activity [GO:0019855]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982] AYSTPDK;DRKVMEYENR;NFLEFQR;TEKISQEREK;VMEYENRIR 5 7.5 0.9741 -2.4135 10.9036 0 0 6.2802 0 0 0 7.66562 7.65449 0 0 0 Q9BPX7 CG025_HUMAN UPF0415 protein C7orf25 C7orf25 Homo sapiens (Human) VEPPRRSSGVGAAR 1 2.9 0.95906 -1.0389 0 0 0 0 0 0 0 0 0 0 0 11.1426 Q9BPY8 HOP_HUMAN Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1) HOPX HOD HOP LAGY NECC1 OB1 Homo sapiens (Human) bundle of His development [GO:0003166]; chaperone-mediated protein complex assembly [GO:0051131]; lung alveolus development [GO:0048286]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone deacetylase regulator activity [GO:0035033] LIFLGCYRR 1 9.9 0.92039 -0.43756 0 0 0 0 0 0 0 0 0 8.9191 0 9.31834 Q9BPZ2 SPI2B_HUMAN Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) SPIN2B SPIN2 Homo sapiens (Human) apoptotic process [GO:0006915]; gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] methylated histone binding [GO:0035064] FDDDFHIYVYDLVKK 1 5.8 0.58836 0.17875 0 0 0 0 0 0 8.65112 0 0 0 0 0 Q9BQ08 RETNB_HUMAN Resistin-like beta (Colon and small intestine-specific cysteine-rich protein) (Colon carcinoma-related gene protein) (Cysteine-rich secreted protein A12-alpha-like 1) (Cysteine-rich secreted protein FIZZ2) (RELMbeta) RETNLB CCRG FIZZ2 HXCP2 RETNL2 UNQ408/PRO770 Homo sapiens (Human) epithelial cell proliferation [GO:0050673] extracellular space [GO:0005615] hormone activity [GO:0005179] DVLNSLEYSPSPISKK 1 14.4 0.56741 0.18224 0 0 0 0 0 0 0 0 0 0 9.33581 0 Q9BQ13 KCD14_HUMAN BTB/POZ domain-containing protein KCTD14 KCTD14 Homo sapiens (Human) protein homooligomerization [GO:0051260] AEAITAR 1 2.7 0.81004 0.0053882 0 0 0 0 8.51452 0 0 0 0 0 0 0 Q9BQ16 TICN3_HUMAN "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 TICN3 UNQ409/PRO771 Homo sapiens (Human) negative regulation of cell motility [GO:2000146]; negative regulation of endopeptidase activity [GO:0010951] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191] DEVEDDYFR;LDTNYDLLLDQSELRSIYLDK 2 6.9 0.95158 -0.70409 0 0 0 0 0 7.0863 0 0 0 0 0 0 Q9BQ24 ZFY21_HUMAN Zinc finger FYVE domain-containing protein 21 (ZF21) ZFYVE21 Homo sapiens (Human) endosome [GO:0005768]; focal adhesion [GO:0005925] metal ion binding [GO:0046872] CGKCFCDRCCSQK;DIHAYTSLR 2 8.7 0.87982 -0.14544 0 0 0 0 7.81686 0 0 0 0 0 0 0 Q9BQ69 MACD1_HUMAN ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) MACROD1 LRP16 Homo sapiens (Human) DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]" AAGPLLTDECR;GVAVKVEEPR;TWAPLAMAAKVDLSTSTDWK 3 12.6 0.91617 -0.43352 0 8.02137 0 0 0 0 0 0 0 0 8.18804 10.7565 Q9BQ70 TCF25_HUMAN Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) TCF25 KIAA1049 NULP1 FKSG26 Homo sapiens (Human) heart development [GO:0007507]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein K48-linked ubiquitination [GO:0061945]; rescue of stalled ribosome [GO:0072344] cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112] DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] LFQEWEAHR;NYEYLIRLFQEWEAHR;SFYLALYK;VLYQRAPR;YSKPGLSMR 5 6.1 0.97266 -2.7786 13.8923 14.391 14.2109 0 13.2842 3.8474 7.41912 11.1568 0 0 0 13.4454 Q9BQ87 TBL1Y_HUMAN "F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)" TBL1Y TBL1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714] GPIFALK;LGCDHPVK 2 2.9 0.91372 -0.39033 0 0 0 0 0 0 0 10.8387 0 0 0 0 Q9BQ89 F110A_HUMAN Protein FAM110A FAM110A C20orf55 F10 Homo sapiens (Human) mitotic spindle organization [GO:0007052] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] AAADLER;RTVLTPSR;TVLTPSRR 3 5.4 0.95532 -0.86222 0 12.4692 0 0 0 0 0 12.2664 0 0 12.1581 0 Q9BQ90 KLDC3_HUMAN Kelch domain-containing protein 3 (Testis intracellular mediator protein) KLHDC3 PEAS Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FNPVSFTWK 1 2.4 0.93177 -0.49042 0 0 0 0 0 0 0 0 0 11.3687 0 0 Q9BQA5 HINFP_HUMAN Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein) HINFP MIZF ZNF743 Homo sapiens (Human) cell cycle G1/S phase transition [GO:0044843]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" CDCCDYSCK;EEEEEGK;LLRDHMRNHVNHYK 3 5.8 0.95598 -0.86987 0 0 0 0 0 0 0 9.52254 0 0 0 0 Q9BQB4 SOST_HUMAN Sclerostin SOST UNQ2976/PRO7455/PRO7476 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cellular response to parathyroid hormone stimulus [GO:0071374]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of Wnt signaling pathway [GO:0030178]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; response to mechanical stimulus [GO:0009612] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein-containing complex [GO:0032991] BMP binding [GO:0036122]; carbohydrate binding [GO:0030246]; DNA-binding transcription factor binding [GO:0140297]; heparin binding [GO:0008201]; molecular function inhibitor activity [GO:0140678] DFGTEAARPQKGR;LVASCKCKR 2 10.3 0.98085 -1.6893 0 11.7489 10.6179 0 0 10.0204 0 0 0 0 0 0 Q9BQB6 VKOR1_HUMAN "Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)" VKORC1 VKOR MSTP134 MSTP576 UNQ308/PRO351 Homo sapiens (Human) blood coagulation [GO:0007596]; bone development [GO:0060348]; peptidyl-glutamic acid carboxylation [GO:0017187]; positive regulation of coagulation [GO:0050820]; regulation of blood coagulation [GO:0030193]; response to organic cyclic compound [GO:0014070]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-insensitive) activity [GO:0047058]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] GSTWGSPGWVR 1 6.7 0.9357 -0.52054 0 0 0 0 0 0 0 0 9.1432 0 0 0 Q9BQC3 DPH2_HUMAN 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) DPH2 DPH2L2 Homo sapiens (Human) protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]; cytosol [GO:0005829] "2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" RGIAIAYEDEGSG 1 2.7 0.74017 0.10806 0 0 10.3306 0 0 0 0 0 0 0 0 0 Q9BQD3 KXDL1_HUMAN KxDL motif-containing protein 1 KXD1 C19orf50 Homo sapiens (Human) lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; vesicle-mediated transport [GO:0016192] BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574] LQQMSER 1 4 0.9376 -0.5756 0 0 0 0 0 0 0 0 0 0 10.6951 0 Q9BQD7 ANKMT_HUMAN Adenine nucleotide translocase lysine N-methyltransferase (ANT-KMT) (EC 2.1.1.-) ANTKMT C16orf24 FAM173A RJD7 Homo sapiens (Human) peptidyl-lysine trimethylation [GO:0018023]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706] mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279] NVSVFLAPSVLPLLEDKLRTELPAGAR 1 11.5 0.6939 0.16215 0 0 0 0 0 0 0 8.54415 0 0 0 0 Q9BQE4 SELS_HUMAN Selenoprotein S (SelS) (VCP-interacting membrane protein) SELENOS SELS VIMP AD-015 SBBI8 Homo sapiens (Human) "cell redox homeostasis [GO:0045454]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of D-glucose import [GO:0046325]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of gluconeogenesis [GO:0006111]; regulation of nitric oxide metabolic process [GO:0080164]; response to glucose [GO:0009749]; response to redox state [GO:0051775]; retrograde protein transport, ER to cytosol [GO:0030970]" cytoplasmic microtubule [GO:0005881]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] antioxidant activity [GO:0016209]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; signaling receptor activity [GO:0038023]; ubiquitin-specific protease binding [GO:1990381] GPSSGGUG;SYKGNAK 2 7.9 0.97955 -1.5381 12.4015 14.2453 13.2547 12.6063 12.0588 11.6678 12.4265 11.8905 12.2951 13.1989 11.5871 12.1794 Q9BQE5 APOL2_HUMAN Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) APOL2 Homo sapiens (Human) acute-phase response [GO:0006953]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; maternal process involved in female pregnancy [GO:0060135] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102] ELEDHIRK 1 2.4 0.84061 -0.043952 0 0 0 0 0 0 0 11.1426 0 0 0 0 Q9BQE6 LBHD1_HUMAN LBH domain-containing protein 1 LBHD1 C11orf48 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] LPNPLWDRGKIGK 1 4.5 0.86802 -0.091601 0 8.26332 0 0 0 0 0 0 0 0 0 0 Q9BQF6 SENP7_HUMAN Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) SENP7 KIAA1707 SSP2 SUSP2 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] SUMO-specific endopeptidase activity [GO:0070139] CLTRKENNLTEDNPNLSMAQR;SHIFSSFFYKCLTRK;STEQTKK;VILTNVLGTELGRKYIR 4 5.2 0.97467 -3.1209 0 0 0 6.10997 10.7074 0 12.0319 0 0 0 0 0 Q9BQG0 MBB1A_HUMAN Myb-binding protein 1A MYBBP1A P160 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of DNA-templated transcription [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1 to G0 transition [GO:1903450]; respiratory electron transport chain [GO:0022904]; ribosome biogenesis [GO:0042254] B-WICH complex [GO:0110016]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] E-box binding [GO:0070888]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714] AAAFQHLLLLVGIHLLK;EVVEQGLLK;LVQQAGR;SPAPGAPTR;SSESEEESEGEESEEEER;SSSSKQEQDLLHKTAR;TLSMREVRSCFEDPEWK 7 7 0.97083 -1.341 0 0 12.5911 0 0 0 0 8.98319 8.35094 9.93433 0 10.3488 Q9BQG2 NUD12_HUMAN NAD-capped RNA hydrolase NUDT12 (DeNADding enzyme NUDT12) (EC 3.6.1.-) (NADH pyrophosphatase NUDT12) (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12) NUDT12 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; mRNA catabolic process [GO:0006402]; mRNA methylguanosine-cap decapping [GO:0110156]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; NAD catabolic process [GO:0019677]; NAD-cap decapping [GO:0110155]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742] cytoplasm [GO:0005737]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] magnesium ion binding [GO:0000287]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; NADPH pyrophosphatase activity [GO:0010943]; phosphodiesterase decapping endonuclease activity [GO:1990174]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; zinc ion binding [GO:0008270] CLLGRQKR;LLNYAGEVPR 2 3.9 0.97929 -1.8884 0 0 0 0 0 0 0 0 0 11.0491 0 0 Q9BQI3 E2AK1_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) EIF2AK1 HRI KIAA1369 PRO1362 Homo sapiens (Human) acute inflammatory response [GO:0002526]; establishment of localization in cell [GO:0051649]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hemoglobin biosynthetic process [GO:0046986]; negative regulation of translational initiation by iron [GO:0045993]; phagocytosis [GO:0006909]; positive regulation of mitophagy [GO:1901526]; protein autophosphorylation [GO:0046777]; protein localization to mitochondrion [GO:0070585]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of translational initiation [GO:0006446]; response to iron ion starvation [GO:1990641] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heme binding [GO:0020037]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] YLNEFEELAILGK 1 2.1 0.79449 0.015904 0 0 11.6236 0 0 0 0 0 0 0 0 0 Q9BQI4 CCDC3_HUMAN Coiled-coil domain-containing protein 3 (Fat/vessel-derived secretory protein) (Favine) CCDC3 Homo sapiens (Human) lipid biosynthetic process [GO:0008610]; negative regulation of gene expression [GO:0010629]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid biosynthetic process [GO:0046889]; signal transduction [GO:0007165] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576] GPVRPPYLRG 1 6.9 0.74019 0.10689 0 0 0 8.25795 0 0 0 0 0 0 0 0 Q9BQI5 SGIP1_HUMAN SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) SGIP1 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; energy homeostasis [GO:0097009]; positive regulation of feeding behavior [GO:2000253]; positive regulation of receptor-mediated endocytosis [GO:0048260]; response to dietary excess [GO:0002021]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793] microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; SH3 domain binding [GO:0017124] FNIKIKPLQSKDILK;KRFAAGK 2 2.7 0.97031 -1.3445 0 0 0 0 0 0 0 0 0 3.52482 0 0 Q9BQI6 SLF1_HUMAN SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) SLF1 ANKRD32 BRCTD1 Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] ANVILPK;GVEHEKIK;HFHYQQLEFGSFLLSR;HIYNRDQK;KDAGFLEMK;LLLQHGGPVLLQQRNAK;VCPGVHTEALMITLEMMCR;WLDETTYEWGYKIEKDSR;YNCIRIDK 9 10.4 0.97602 -4.5643 7.22526 0 0 11.0507 9.65718 10.7201 0 7.56301 6.91743 6.71493 0 0 Q9BQI6 SLF1_HUMAN SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) SLF1 ANKRD32 BRCTD1 Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] QTKISGKMQDFLK;WLDETTYEWGYKIEKDSR 2 17.3 0.86552 -0.092425 0 0 5.61049 0 0 0 0 0 0 0 0 0 Q9BQI7 PSD2_HUMAN PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) PSD2 EFA6C Homo sapiens (Human) regulation of ARF protein signal transduction [GO:0032012] cleavage furrow [GO:0032154]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] DATGPDT;EAEEYRLKEHYLTFEK;EEDKLLSAVPEEGDATR;EHYLTFEK;LATLEGDDPSLR;LYHLEGFQRCDVARQLGK;SRYETYIHLLAMK;TLYNSIKNEK;VHHALATRASDYSKK 9 14 0.97824 -6.4248 8.02054 7.12039 0 8.5089 9.18822 0 0 8.63085 10.7074 7.69662 9.09017 11.8604 Q9BQK8 LPIN3_HUMAN Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) LPIN3 LIPN3L Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] IFTVNPRGELIQELIKNHK;SLRLSSDQIRR;TAAKEQQGEK 3 4.7 0.96473 -1.2213 8.87203 0 0 8.61739 0 0 0 0 0 9.40318 0 0 Q9BQL6 FERM1_HUMAN Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) FERMT1 C20orf42 KIND1 URP1 Homo sapiens (Human) "basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; establishment of epithelial cell polarity [GO:0090162]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of timing of anagen [GO:0051886]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin activation [GO:0033625]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]" cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; integrin binding [GO:0005178] ELEQGEPLEK;GCEVVPDVNVAGRKFGIK;LLFTPQHK;LLPKAFKQYWFIFK;TQKCFHK 5 11.5 0.97843 -2.1163 8.70563 0 0 0 0 0 0 0 13.37 9.06639 0 0 Q9BQM9 CT144_HUMAN Uncharacterized protein C20orf144 (Bcl-2-like protein from testis) (Bclt) C20orf144 Homo sapiens (Human) IDYASGAGLGSPAAPRLR;KPATRIVLILPLDK 2 20.9 0.97586 -1.4484 0 0 0 0 0 0 0 10.8045 0 0 0 0 Q9BQN1 FA83C_HUMAN Protein FAM83C FAM83C C20orf128 Homo sapiens (Human) epidermal growth factor receptor signaling pathway [GO:0007173] protein kinase binding [GO:0019901] ASPSQSRGQLDLLVPFPRAR;IVEDFDR;YHQLHGARQGTEPGGPK 3 5.9 0.95383 -0.91792 0 0 0 0 8.59302 6.54218 0 0 0 0 0 0 Q9BQP9 BPIA3_HUMAN "BPI fold-containing family A member 3 (Short palate, lung and nasal epithelium carcinoma-associated protein 3)" BPIFA3 C20orf71 SPLUNC3 Homo sapiens (Human) extracellular region [GO:0005576] lipid binding [GO:0008289] IQNIHFGDR;LLIFLGLLALPLAPHK 2 11.5 0.93041 -0.4783 0 0 0 0 0 0 0 4.82797 0 0 0 0 Q9BQQ7 RTP3_HUMAN Receptor-transporting protein 3 (3CxxC-type zinc finger protein 3) (Transmembrane protein 7) RTP3 TMEM7 Z3CXXC3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849] ILKNLVFRILK 1 4.7 0.86939 -0.098172 0 0 0 0 0 0 3.10591 0 0 0 0 0 Q9BQR3 PRS27_HUMAN Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin) PRSS27 MPN UNQ1884/PRO4327 Homo sapiens (Human) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ILQKLAVPIIDTPK 1 4.8 0.92208 -0.44318 0 10.1712 0 0 0 0 0 0 0 0 10.5171 0 Q9BQS2 SYT15_HUMAN Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149] KHQLLGQVLFPLKNETLVGDCR;LLVGLIK;RWHALCRTTEP 3 9.5 0.97924 -1.8944 0 0 0 0 0 0 0 0 5.46989 0 5.33432 0 Q9BQS6 HSPB9_HUMAN Heat shock protein beta-9 (HspB9) (Cancer/testis antigen 51) (CT51) (Heat shock protein family B member 9) HSPB9 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] VGNTFSNESR 1 6.3 0.89667 -0.23453 0 0 0 0 0 0 0 8.1282 0 0 0 0 Q9BQS7 HEPH_HUMAN Hephaestin (Hp) (EC 1.16.3.1) HEPH KIAA0698 UNQ2562/PRO6242 Homo sapiens (Human) intestinal iron absorption [GO:0160179]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of iron export across plasma membrane [GO:1904040] basolateral plasma membrane [GO:0016323]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491] KTIYKEYK;VPPRDIEEGNVK 2 1.7 0.88743 -0.18623 0 0 0 0 0 0 8.24869 0 0 0 0 0 Q9BQS7 HEPH_HUMAN Hephaestin (Hp) (EC 1.16.3.1) HEPH KIAA0698 UNQ2562/PRO6242 Homo sapiens (Human) intestinal iron absorption [GO:0160179]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of iron export across plasma membrane [GO:1904040] basolateral plasma membrane [GO:0016323]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491] GKCAQPAWRK;KTIYKEYK 2 1.5 0.96714 -1.3076 0 0 0 0 0 11.6269 0 0 0 9.68547 13.5783 0 Q9BQS8 FYCO1_HUMAN FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) FYCO1 ZFYVE7 Homo sapiens (Human) plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098] autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020] metal ion binding [GO:0046872] CCRACFQK;EDARASLERLVK;GLQEAQLDDTK;IQEYYNK;LQELLAHTSSWEEELAELR;NAGEECK;SDALEFQQK 7 4.9 0.97507 -3.1433 0 4.34795 9.74352 0 0 0 0 10.6354 6.72274 0 0 8.048 Q9BQT9 CSTN3_HUMAN Calsyntenin-3 (Alcadein-beta) (Alc-beta) CLSTN3 CS3 KIAA0726 Homo sapiens (Human) "adaptive thermogenesis [GO:1990845]; cold-induced thermogenesis [GO:0106106]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of lipid droplet fusion [GO:0160078]; negative regulation of lipid storage [GO:0010888]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; protein secretion [GO:0009306]; regulation of cell growth [GO:0001558]; regulation of excitatory synapse assembly [GO:1904889]; regulation of presynapse assembly [GO:1905606]; regulation of synapse assembly [GO:0051963]; sympathetic neuron projection extension [GO:0097490]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; enzyme inhibitor activity [GO:0004857]; neurexin family protein binding [GO:0042043] DESWQGTVTDTR;FTVTAYDCGKKR 2 2.5 0.85924 -0.082023 0 0 0 0 0 0 0 0 0 6.04601 0 8.49149 Q9BQT9 CSTN3_HUMAN Calsyntenin-3 (Alcadein-beta) (Alc-beta) CLSTN3 CS3 KIAA0726 Homo sapiens (Human) "adaptive thermogenesis [GO:1990845]; cold-induced thermogenesis [GO:0106106]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of lipid droplet fusion [GO:0160078]; negative regulation of lipid storage [GO:0010888]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; protein secretion [GO:0009306]; regulation of cell growth [GO:0001558]; regulation of excitatory synapse assembly [GO:1904889]; regulation of presynapse assembly [GO:1905606]; regulation of synapse assembly [GO:0051963]; sympathetic neuron projection extension [GO:0097490]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; enzyme inhibitor activity [GO:0004857]; neurexin family protein binding [GO:0042043] AVLMAAR;VGLQGQK 2 3.8 0.9426 -0.62099 0 0 0 0 8.17996 0 0 0 0 0 10.3222 0 Q9BQW3 COE4_HUMAN Transcription factor COE4 (Early B-cell factor 4) (EBF-4) (Olf-1/EBF-like 4) (O/E-4) (OE-4) EBF4 COE4 KIAA1442 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell apoptotic process [GO:0070231] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GASRPVF;LIDSMSK;VLLTHEIMCSRCCDR 3 4.5 0.9613 -1.0641 0 3.82008 0 0 0 0 0 8.15522 0 0 0 0 Q9BQY6 WFDC6_HUMAN WAP four-disulfide core domain protein 6 (Putative protease inhibitor WAP6) WFDC6 C20orf171 WAP6 Homo sapiens (Human) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] VSLTLYHKEELE 1 14 0.91738 -0.42444 9.67566 0 0 0 0 0 0 0 0 0 0 0 Q9BR01 ST4A1_HUMAN Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) SULT4A1 SULTX3 Homo sapiens (Human) dendrite arborization [GO:0140059]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146] GTFQEFCRRFMNDK 1 4.9 0.86491 -0.088044 0 0 0 0 0 0 5.89792 0 0 0 0 0 Q9BR09 NEUL2_HUMAN Neuralized-like protein 2 NEURL2 C20orf163 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] VDPSGTRATR 1 3.5 0.88667 -0.18257 0 0 0 0 0 0 0 0 10.3796 0 0 0 Q9BR10 SPT25_HUMAN Spermatogenesis-associated protein 25 (Testis-specific gene 23 protein) SPATA25 C20orf165 TSG23 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] KEYSRNCHK 1 4 0.97533 -1.4582 8.42021 0 0 0 0 0 0 0 0 0 0 0 Q9BR11 ZSWM1_HUMAN Zinc finger SWIM domain-containing protein 1 ZSWIM1 C20orf162 Homo sapiens (Human) nucleus [GO:0005634] zinc ion binding [GO:0008270] LYTLLSNCIPPAK 1 2.7 0.84999 -0.078058 0 0 0 0 0 0 0 0 0 0 0 11.4376 Q9BR76 COR1B_HUMAN Coronin-1B (Coronin-2) CORO1B Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; wound healing [GO:0042060] actin filament [GO:0005884]; cell leading edge [GO:0031252]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802] EPQRGMGSMPK;GMGSMPK;GMGSMPKR;LEEQLGRMENGDA 4 5.1 0.98067 -2.0348 8.3458 0 9.51337 0 0 0 10.3868 0 0 10.2052 0 0 Q9BR84 ZN559_HUMAN Zinc finger protein 559 ZNF559 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFRYSSHLSQHKR;DVMLENYK;TCECNQCEK;THTQEKPYKCSDCEK 4 8.4 0.88145 -0.15233 0 0 3.80488 0 6.69516 0 0 0 10.1033 7.83794 0 0 Q9BRA0 NAA38_HUMAN "N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2)" NAA38 LSMD1 MAK31 PFAAP2 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066] cytoplasm [GO:0005737]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] AAPVLGLARALVLGLR;AAWAARSER;MTDGRTLVGCFLCTDR;TMRIRMTDGR 4 26.6 0.97608 -2.2639 9.1845 0 0 5.21634 0 0 0 0 0 0 3.69276 0 Q9BRA2 TXD17_HUMAN Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) TXNDC17 TXNL5 Homo sapiens (Human) tumor necrosis factor-mediated signaling pathway [GO:0033209] cytosol [GO:0005829]; extracellular exosome [GO:0070062] peroxidase activity [GO:0004601]; protein-disulfide reductase (NAD(P)H) activity [GO:0047134] HISEGCVFIYCQVGEKPYWK;VTAVPTLLK 2 23.6 0.082278 0.39372 12.0638 0 0 0 0 0 0 0 10.8869 9.50046 0 9.43235 Q9BRB3 PIGQ_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) PIGQ GPI1 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] AENPAQLMRK;LLVVAVQGLIHLLVDLINSLPLYSLGLR;LSTCEQLRHR 3 8.3 0.74925 0.078451 0 6.27713 12.3518 0 0 0 0 11.2649 0 0 4.74878 0 Q9BRC7 PLCD4_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4)" PLCD4 Homo sapiens (Human) acrosome reaction [GO:0007340]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435] RAEVQELFESFSADGQK;TKEGSIVDPLVKVQIFGVR 2 4.7 0.67926 0.16561 0 0 0 7.40965 0 0 0 4.12474 0 0 0 0 Q9BRD0 BUD13_HUMAN BUD13 homolog BUD13 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RES complex [GO:0070274]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] EQDQETMAFEAEFQYAETVFRDK;LLGGHNEDLPSNR;SNGFEQKR;WKLLGGHNEDLPSNRHFR 4 7.9 0.96897 -1.3323 11.642 8.75392 0 0 0 0 0 7.41878 6.16742 9.12554 9.12379 0 Q9BRF8 CPPED_HUMAN Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) CPPED1 CSTP1 Homo sapiens (Human) azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AWSTGDCDNGGDEWEQEIR;LADKFIHAGVKVVFSGHYHR;TLAAFPAEK 3 15.3 0.88871 -0.1881 0 0 0 0 0 0 7.01201 0 0 0 9.01114 0 Q9BRG1 VPS25_HUMAN Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) VPS25 DERP9 EAP20 Homo sapiens (Human) macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] KGNLEWLDKSK;QLAAWCSLVLSFCR 2 14.2 0.96491 -1.2523 0 0 12.2571 0 8.95099 10.1037 0 0 0 0 0 0 Q9BRG2 SH23A_HUMAN SH2 domain-containing protein 3A (Novel SH2-containing protein 1) SH2D3A NSP1 UNQ175/PRO201 Homo sapiens (Human) JNK cascade [GO:0007254]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] LEHTWRQLRR;LLWGSRGAGAPR;RLLWGSRGAGAPR 3 4 0.91512 -0.36728 0 0 0 0 0 0 0 0 13.7616 9.28395 0 0 Q9BRH9 ZN251_HUMAN Zinc finger protein 251 ZNF251 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VFKCDICSKTFK 1 1.8 0.76926 0.057582 0 0 0 0 0 0 0 0 0 8.6845 0 0 Q9BRJ2 RM45_HUMAN "Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial) (L45mt) (MRP-L45)" MRPL45 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ISSLSKEGLIERTER 1 4.9 0.96111 -1.0635 0 0 0 8.79808 0 0 0 0 0 0 0 0 Q9BRJ6 CHOLN_HUMAN Protein cholesin C7orf50 FP15621 Homo sapiens (Human) negative regulation of cholesterol biosynthetic process [GO:0045541] extracellular space [GO:0005615] hormone activity [GO:0005179]; RNA binding [GO:0003723] EAGLVAQHPPAR;ELTVQKAEALMR;SGAELALDYLCR;VLERKLK 4 22.2 0.96378 -1.1112 0 11.0865 0 0 0 0 8.87206 0 3.47457 0 0 10.5562 Q9BRK0 REEP2_HUMAN Receptor expression-enhancing protein 2 REEP2 C5orf19 SGC32445 Homo sapiens (Human) endoplasmic reticulum tubular network organization [GO:0071786]; protein transport into membrane raft [GO:0032596]; regulation of intracellular transport [GO:0032386]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; taste receptor binding [GO:0031883] AEPLASK;EIDEYITQARDK 2 7.5 0.94211 -0.61816 0 0 0 0 0 0 0 0 8.51013 0 0 0 Q9BRK3 MXRA8_HUMAN Matrix remodeling-associated protein 8 (Limitrin) MXRA8 Homo sapiens (Human) cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; establishment of glial blood-brain barrier [GO:0060857] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] CQSPRMVWTQDR 1 2.7 0.83571 -0.031 0 0 0 0 0 0 5.91559 0 0 0 0 0 Q9BRK4 LZTS2_HUMAN Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) LZTS2 KIAA1813 LAPSER1 Homo sapiens (Human) fibroblast proliferation [GO:0048144]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; nuclear export [GO:0051168]; primary ureteric bud growth [GO:0060682]; spindle midzone assembly [GO:0051255]; ureter morphogenesis [GO:0072197]; Wnt signaling pathway [GO:0016055] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; vesicle [GO:0031982] AAAGVGGSLRAQVER;ARGLQEAARAR;ELELEACSQELQRHRQEAEQLR;HHGPPGPTFFR;LAWQAEK 5 9.9 0.97505 -3.1852 0 0 11.3075 0 0 12.4692 9.28559 0 0 0 0 0 Q9BRK5 CAB45_HUMAN 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) SDF4 CAB45 PSEC0034 Homo sapiens (Human) calcium-ion regulated exocytosis [GO:0017156]; cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; maintenance of synapse structure [GO:0099558]; response to ethanol [GO:0045471]; UV protection [GO:0009650]; zymogen granule exocytosis [GO:0070625] bleb [GO:0032059]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] VDEETQEVLENLK 1 3.6 0.93712 -0.56716 0 0 0 0 0 0 0 0 0 0 8.8635 0 Q9BRP1 PDD2L_HUMAN Programmed cell death protein 2-like PDCD2L Homo sapiens (Human) apoptotic process [GO:0006915] cytoplasm [GO:0005737]; membrane [GO:0016020] IAACQEQILR;SQCLQVPER 2 5.3 0.95512 -0.81785 0 0 7.82114 0 0 0 0 0 0 0 0 0 Q9BRP4 PAAF1_HUMAN Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71) PAAF1 WDR71 Homo sapiens (Human) transcription initiation at RNA polymerase II promoter [GO:0006367] proteasome complex [GO:0000502]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669] SIHISCPK;SITCLDISSR 2 4.6 0.96556 -1.1343 0 0 0 0 0 0 0 0 12.852 0 0 0 Q9BRP7 FDXA1_HUMAN Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDX-ACDB domain-containing protein 1) FDXACB1 Homo sapiens (Human) rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] rRNA (uridine-N3-)-methyltransferase activity [GO:0070042] AGVAKNR;AVAGYKCTGYR;KGFDELEFHTVAR 3 5 0.97479 -3.2377 0 0 0 12.3265 0 8.82645 0 0 10.3522 0 0 0 Q9BRP8 PYM1_HUMAN Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) PYM1 PYM WIBG Homo sapiens (Human) "exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ribosome binding [GO:0043022]; RNA binding [GO:0003723] IQAGEVSQPSK 1 5.4 0.90848 -0.30241 0 0 0 0 0 0 0 9.31897 0 0 0 0 Q9BRP9 YK016_HUMAN Putative uncharacterized protein MGC13053 Homo sapiens (Human) GAMKGRR;VGVAGGS 2 9.5 0.71463 0.14213 0 12.2179 12.5177 10.3544 9.85066 0 0 0 0 0 11.3108 9.83172 Q9BRQ3 NUD22_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT22 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 22) (Nudix motif 22) NUDT22 PP11246 Homo sapiens (Human) nucleoplasm [GO:0005654] GDP-mannose hydrolase activity [GO:0052751]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768] NETSAGR 1 2.3 0.61077 0.17587 0 0 0 0 0 0 9.52705 0 0 0 0 0 Q9BRQ4 CF300_HUMAN Cilia- and flagella-associated protein 300 CFAP300 C11orf70 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] IKAQAFGFDQTFQSYRK;VLLVEDSEK 2 9.7 0.7486 0.084729 13.3784 0 0 0 0 0 0 0 0 11.6529 0 0 Q9BRQ6 MIC25_HUMAN MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) CHCHD6 CHCM1 MIC25 Homo sapiens (Human) cristae formation [GO:0042407]; DNA damage response [GO:0006974]; inner mitochondrial membrane organization [GO:0007007] cytosol [GO:0005829]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] APHKESTLPR;EGVKRYEQEHAAIQDK;EQLERIER 3 14.5 0.97322 -2.8804 0 0 9.19049 0 0 0 0 0 0 8.00742 0 9.96551 Q9BRQ8 FSP1_HUMAN Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein) AIFM2 AMID PRG3 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; cellular detoxification [GO:1990748]; negative regulation of ferroptosis [GO:0110076]; positive regulation of apoptotic process [GO:0043065]; regulation of cellular response to oxidative stress [GO:1900407]; ubiquinone metabolic process [GO:0006743]; vitamin K metabolic process [GO:0042373] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]" DLFVSTSWKTMR;VSNLEELPLNEYREYIK 2 7.8 0.95434 -0.90886 0 10.401 0 10.4345 0 0 0 0 0 0 0 0 Q9BRR0 ZKSC3_HUMAN Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47) ZKSCAN3 ZFP47 ZNF306 ZNF309 ZSCAN13 Homo sapiens (Human) autophagy [GO:0006914]; lysosome organization [GO:0007040]; negative regulation of autophagy [GO:0010507]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" EALSRLRELCR;EHGKISCHLR 2 3.9 0.90738 -0.30542 0 9.96795 7.53535 0 0 0 0 0 0 0 0 0 Q9BRR3 PGAP4_HUMAN Post-GPI attachment to proteins factor 4 (Post-GPI attachment to proteins GalNAc transferase 4) (Transmembrane protein 246) PGAP4 C9orf125 TMEM246 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] LLHSYFYLR;YEGTEDDYGDDPSTNSFEK 2 6.9 0.95331 -0.67567 0 0 0 0 4.43029 0 0 0 0 0 0 0 Q9BRR8 GPTC1_HUMAN G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) GPATCH1 ECGP GPATC1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] AALLYASSHSTLSSR;EEEHAPELSANQTVNK;SLPLRRQ 3 4.1 0.98051 -1.6131 0 0 0 6.0624 0 0 0 10.9342 0 0 0 0 Q9BRR9 RHG09_HUMAN Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) ARHGAP9 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774] "GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" AQASSEQPPPLPRKMCR;KTNSDWWLAR 2 3.6 0.88972 -0.20896 9.60032 8.25338 13.17 0 7.44733 0 0 0 0 0 0 0 Q9BRS2 RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) RIOK1 RIO1 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274] "cytosol [GO:0005829]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DKADRATVEQVLDPR;ELYLQVIQYMRRMYQDAR;HTTDPDIDKK 3 7.6 0.80328 0.013358 0 0 0 0 5.35783 0 0 0 0 4.29374 3.39944 9.91731 Q9BRS8 LARP6_HUMAN La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) LARP6 Homo sapiens (Human) positive regulation of collagen biosynthetic process [GO:0032967]; regulation of translation [GO:0006417]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; myosin binding [GO:0017022]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825] ELPPDIRR;GAGDPAR;QAEMGTQEK 3 4.9 0.95702 -0.99751 0 0 0 0 0 0 0 0 0 10.3165 0 10.5407 Q9BRU2 TCAL7_HUMAN Transcription elongation factor A protein-like 7 (TCEA-like protein 7) (Transcription elongation factor S-II protein-like 7) TCEAL7 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088] nucleoplasm [GO:0005654]; nucleus [GO:0005634] EGDEMERCLEEIR 1 13 0.92384 -0.44961 0 0 0 0 0 0 0 0 0 0 8.78774 0 Q9BRU9 UTP23_HUMAN rRNA-processing protein UTP23 homolog UTP23 C8orf53 Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]" nucleolus [GO:0005730]; small-subunit processome [GO:0032040] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181] IRNRSNPK;NTEQSRRK 2 6.4 0.97284 -2.6072 0 0 10.0937 0 0 0 0 0 0 0 0 0 Q9BRX5 PSF3_HUMAN DNA replication complex GINS protein PSF3 (GINS complex subunit 3) GINS3 PSF3 Homo sapiens (Human) DNA unwinding involved in DNA replication [GO:0006268]; mitotic DNA replication initiation [GO:1902975] CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LELPLWLAK;TETAMPRLGAFFLER 2 11.1 0.93251 -0.49183 11.505 0 0 0 0 2.50442 0 0 0 0 0 0 Q9BRX8 PXL2A_HUMAN Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) PRXL2A C10orf58 FAM213A PAMM PRO2290 PSEC0139 UNQ611/PRO1198 Homo sapiens (Human) regulation of osteoclast differentiation [GO:0045670] cytoplasm [GO:0005737]; extracellular region [GO:0005576] antioxidant activity [GO:0016209] EEAADLSSLK;LGVWYNFFR 2 8.3 0.90874 -0.30161 0 11.0955 0 5.12429 0 0 0 0 0 0 0 0 Q9BRX9 WDR83_HUMAN WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1) WDR83 MORG1 Homo sapiens (Human) "inflammatory response to wounding [GO:0090594]; mRNA splicing, via spliceosome [GO:0000398]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; spliceosomal complex [GO:0005681] TLKLWNPLRGTLLR 1 4.4 0.86892 -0.090713 0 0 0 0 0 0 0 9.7628 0 0 0 0 Q9BRY0 S39A3_HUMAN Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) SLC39A3 ZIP3 Homo sapiens (Human) cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886] zinc ion transmembrane transporter activity [GO:0005385] ELEEKSDR;IIETDFEKAHR;LLKVLFLVLGYTVLAGMVFLK 3 12.7 0.97312 -2.9453 0 0 0 0 0 9.35491 8.11946 0 0 0 0 0 Q9BRZ2 TRI56_HUMAN E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] cytoplasm [GO:0005737]; cytosol [GO:0005829] RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ITGLCPFGPR 1 1.3 0.91757 -0.35954 0 0 0 0 0 0 0 0 0 0 10.8451 0 Q9BS26 ERP44_HUMAN Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580] protein disulfide isomerase activity [GO:0003756] DLAEITTLDR;LAPSEYR;MHPAVFLSLPDLR 3 7.4 0.95296 -0.76282 0 0 0 0 0 0 10.3277 0 0 9.23019 0 0 Q9BS31 ZN649_HUMAN Zinc finger protein 649 ZNF649 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] extracellular space [GO:0005615]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LTEHERAHR;RTGQRYEHGR 2 3.8 0.93661 -0.54506 0 9.35548 0 0 0 0 0 0 0 0 0 10.2857 Q9BS34 ZN670_HUMAN Zinc finger protein 670 ZNF670 Homo sapiens (Human) lipid metabolic process [GO:0006629]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LYHCKQCGK;STYLGIHER 2 4.6 0.95561 -0.84201 8.03788 0 0 0 0 0 0 0 0 0 9.67266 0 Q9BS86 ZPBP1_HUMAN Zona pellucida-binding protein 1 (Inner acrosomal membrane IAM38) (Sp38) ZPBP ZPBP1 Homo sapiens (Human) acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199] AAILLFISAFLVRVPSSVGHLVRLPR;IVGSTSFPVK;KLLQILSKLLLDLSCEISLLK;LLQILSKLLLDLSCEISLLK 4 16.2 0.7395 0.10764 0 0 0 0 0 7.33307 10.3323 5.23775 5.81062 0 7.76315 0 Q9BS92 NPS3B_HUMAN Protein NipSnap homolog 3B (NipSnap3B) (SNAP1) NIPSNAP3B NIPSNAP3 Homo sapiens (Human) mitophagy [GO:0000423] mitochondrion [GO:0005739] AINAHVNLGYTK;ALANCKEWQEQSIIPNLAR;EWQEQSIIPNLARIDK 3 13.8 0.88741 -0.18523 0 8.71596 0 0 9.41352 0 0 0 6.04876 0 0 3.48684 Q9BSC4 NOL10_HUMAN Nucleolar protein 10 NOL10 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IEETRAQR;IELIQDFEMPTVCTTIK 2 3.6 0.98012 -1.6522 11.3558 0 0 0 0 0 0 0 0 0 0 10.7065 Q9BSD3 RHNO1_HUMAN "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)" RHNO1 C12orf32 RHINO HKMT1188 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; positive regulation of G0 to G1 transition [GO:0070318]; protein localization to site of double-strand break [GO:1990166]; recombinational repair [GO:0000725] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463] HSCASTQLPITHTR;RRQHLLAYLR 2 10.1 0.97401 -1.3951 0 0 0 0 0 0 0 0 0 13.3066 0 9.71426 Q9BSD7 NTPCR_HUMAN Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase) NTPCR C1orf57 Homo sapiens (Human) membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; CTPase activity [GO:0043273]; DNA clamp loader activity [GO:0003689]; membrane scission GTPase motor activity [GO:1990606]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA binding [GO:0003723] IGFDVVTLSGTR 1 6.3 0.80395 0.013439 0 0 0 0 0 0 0 7.84844 0 0 8.02896 0 Q9BSE4 HERP2_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein HERPUD2 Homo sapiens (Human) endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283] membrane [GO:0016020] DQRLVYSGR;DWLDWMYTFSR 2 4.9 0.97762 -1.5168 0 0 0 9.4617 0 0 0 0 0 0 0 0 Q9BSE5 GDAH_HUMAN "Guanidino acid hydrolase, mitochondrial (EC 3.5.3.-) (Arginase, mitochondrial) (EC 3.5.3.1) (Guanidinobutyrase, mitochondrial) (EC 3.5.3.7) (Guanidinopropionase, mitochondrial) (EC 3.5.3.17)" AGMAT GDAH Homo sapiens (Human) "agmatine biosynthetic process [GO:0097055]; putrescine biosynthetic process from arginine, using agmatinase [GO:0033389]; urea cycle [GO:0000050]" mitochondrion [GO:0005739] agmatinase activity [GO:0008783]; arginase activity [GO:0004053]; guanidinobutyrase activity [GO:0047971]; guanidinopropionase activity [GO:0047972]; metal ion binding [GO:0046872] IQEAYEK 1 2 0.83639 -0.034429 0 12.5044 0 10.4517 11.2813 0 0 0 9.12223 14.0909 14.0242 11.0298 Q9BSF4 TIM29_HUMAN Mitochondrial import inner membrane translocase subunit Tim29 (TIM29) TIMM29 c19orf52 Homo sapiens (Human) protein insertion into mitochondrial inner membrane [GO:0045039] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] protein transporter activity [GO:0140318] YKPVVLTDDQVDQALWEEQVLQKEKK 1 10 0.68305 0.16504 0 0 0 0 0 0 0 0 7.84906 0 0 0 Q9BSF8 BTBDA_HUMAN BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) BTBD10 GMRP1 Homo sapiens (Human) phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; type B pancreatic cell proliferation [GO:0044342] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] NIRTSER;VTLIVDNTR 2 3.4 0.98037 -1.8146 11.1065 0 0 0 0 0 0 0 0 0 0 0 Q9BSG1 ZNF2_HUMAN Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661) ZNF2 ZNF661 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" HLMSHTGESPYECSVCSKAFFDR;HQECSDCGK 2 7.5 0.87154 -0.10203 0 0 0 0 6.76871 0 0 0 0 6.66747 0 0 Q9BSH4 TACO1_HUMAN Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) TACO1 CCDC44 PRO0477 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617]; motor learning [GO:0061743]; regulation of mitochondrial translation [GO:0070129] mitochondrion [GO:0005739] mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843] STIETALKMEK 1 3.7 0.92195 -0.44289 0 0 0 0 0 4.54881 0 0 0 0 0 0 Q9BSI4 TINF2_HUMAN TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) TINF2 TIN2 Homo sapiens (Human) "negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of telomere maintenance [GO:0032206]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]" "chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; perinucleolar chromocenter [GO:0010370]; shelterin complex [GO:0070187]" telomeric DNA binding [GO:0042162] FAAAASWQVVR;VLEFLRSLR 2 4.4 0.95931 -1.0458 0 0 0 0 0 0 0 8.44663 0 0 0 0 Q9BSJ2 GCP2_HUMAN Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) TUBGCP2 GCP2 Homo sapiens (Human) brain development [GO:0007420]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] KPVEDITPPRLEALLELALR;SQKATPQVPVLRGPPAPAPR 2 4.4 0.64101 0.1734 0 0 0 0 0 0 0 0 5.79345 0 8.0766 0 Q9BSJ5 CQ080_HUMAN Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) MTNAP1 C17orf80 HLC8 MIG3 Homo sapiens (Human) extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] LSQGWIR;LVVDKPEQTVK;MSDNPPRMEVCPYCK 3 5.8 0.96142 -1.0659 0 9.90641 4.34696 0 0 0 4.66021 9.77174 0 6.57864 0 0 Q9BSJ6 PIMRE_HUMAN Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) PIMREG CATS FAM64A RCS1 Homo sapiens (Human) cell division [GO:0051301] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] SALGAVSQRIQESCQSGTK 1 7.7 0.91757 -0.42838 0 0 0 0 0 0 0 8.27575 0 0 0 0 Q9BSJ8 ESYT1_HUMAN Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) ESYT1 FAM62A KIAA0747 MBC2 Homo sapiens (Human) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intermembrane lipid transfer [GO:0120009] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; phospholipid transfer activity [GO:0120014] ALTLGALTLPLAR;LGTQTFCSR;LLVPLVPDLQDVAQLRSPLPR;WFTLSSGQGQVLLR 4 5.2 0 2.6755 8.52951 0 0 0 5.91334 0 0 9.5813 9.35215 0 7.07746 8.76434 Q9BSK4 FEM1A_HUMAN Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein) FEM1A EPRAP Homo sapiens (Human) negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151] EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; molecular adaptor activity [GO:0060090]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DGKLQLLQKLLSGR;GVREVERALQLPR;IPYKGFIPEDLEAFIELH;LQLLQKLLSGRSR 4 7 0.90971 -0.29553 0 0 3.72825 0 0 0 0 10.5513 0 0 3.36121 0 Q9BSL1 UBAC1_HUMAN Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) UBAC1 GBDR1 KPC2 UBADC1 Homo sapiens (Human) protein maturation [GO:0051604]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628] MFVQEEK;VNNNQQNAACEWLLGDRKPSPEELDK 2 8.1 0.95513 -0.78976 0 0 0 0 0 0 0 0 11.439 0 0 0 Q9BSN7 TM204_HUMAN Transmembrane protein 204 (Claudin-like protein 24) TMEM204 C16orf30 CLP24 UNQ6509/PRO21434 Homo sapiens (Human) lymph vessel development [GO:0001945]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; smooth muscle cell differentiation [GO:0051145] adherens junction [GO:0005912]; plasma membrane [GO:0005886] SLTARFR 1 3.1 0.98035 -1.6404 0 0 10.5389 0 0 0 0 0 0 0 0 0 Q9BSQ5 CCM2_HUMAN Cerebral cavernous malformations 2 protein (Malcavernin) CCM2 C7orf22 PP10187 Homo sapiens (Human) blood vessel endothelial cell differentiation [GO:0060837]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial tube morphogenesis [GO:0061154]; endothelium development [GO:0003158]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; regulation of angiogenesis [GO:0045765]; stress-activated MAPK cascade [GO:0051403]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] HSSCRQRR;KFLLLGLRPFIPEK;QLYGDSRK 3 6.2 0.91011 -0.31826 0 0 0 11.4901 0 0 13.5713 0 13.5204 0 4.55575 0 Q9BST9 RTKN_HUMAN Rhotekin RTKN RTKN1 Homo sapiens (Human) actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; regulation of apoptotic process [GO:0042981]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; signal transduction [GO:0007165] actomyosin contractile ring [GO:0005826]; cytosol [GO:0005829] GTP binding [GO:0005525]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] GSALEMEFK;VTVARGSALEMEFK 2 2.5 0.9549 -0.94703 0 0 0 0 0 10.4838 0 10.2382 0 0 0 0 Q9BSV6 SEN34_HUMAN tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) TSEN34 LENG5 SEN34 Homo sapiens (Human) mRNA processing [GO:0006397]; tRNA-type intron splice site recognition and cleavage [GO:0000379] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] LVVEVANGRSLVWGAEAVQALR;TVGALPR 2 9.4 0.91601 -0.33366 9.37315 0 10.6625 0 0 0 0 0 11.0158 0 0 0 Q9BSW2 EFC4B_HUMAN EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) CRACR2A EFCAB4B RAB46 Homo sapiens (Human) activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; protein localization [GO:0008104]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] LKLTNQELARELER;VTESLQREK 2 3.1 0.97083 -1.3356 0 0 0 0 0 0 11.2853 0 0 0 0 0 Q9BSW7 SYT17_HUMAN Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) SYT17 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149] IQLVHGLKLVK;IQLVHGLKLVKTK 2 2.7 0.76429 0.066097 9.68587 0 6.9377 0 0 0 3.11916 6.06493 0 0 0 0 Q9BSY4 CHCH5_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 CHCHD5 C2orf9 Homo sapiens (Human) cellular respiration [GO:0045333] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] ELEQYGQCVAAKPESWQR 1 16.4 0.86459 -0.085083 0 0 0 0 0 0 0 8.81391 0 0 0 0 Q9BT04 FUZZY_HUMAN Protein fuzzy homolog FUZ FY Homo sapiens (Human) cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; intraciliary transport [GO:0042073]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314]; negative regulation of neural crest formation [GO:0090301]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062] phosphatidylinositol binding [GO:0035091] LGTPEAVLLPWLVGSLPPQTAR 1 5.3 0.78746 0.017575 0 0 0 0 0 4.27627 0 0 0 0 0 0 Q9BT09 CNPY3_HUMAN Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409 Homo sapiens (Human) innate immune response [GO:0045087] endoplasmic reticulum lumen [GO:0005788] signaling receptor binding [GO:0005102] LIEVTETICK 1 3.6 0.92375 -0.44899 0 0 0 0 10.1458 0 0 0 0 0 0 0 Q9BT17 MTG1_HUMAN Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1) MTG1 GTPBP7 Homo sapiens (Human) mitochondrial translation [GO:0032543]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ENFPLCGR 1 2.4 0.91576 -0.39076 0 0 0 0 0 0 0 0 10.3048 0 0 0 Q9BT22 ALG1_HUMAN "Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1)" ALG1 HMAT1 HMT1 PSEC0061 UNQ861/PRO1870 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] chitobiosyldiphosphodolichol beta-mannosyltransferase activity [GO:0004578]; mannosyltransferase activity [GO:0000030] DAGSGLVTR;LFMKLGSMHSPFR;LSHLNLCVTNAMR 3 7.5 0.97856 -1.9414 0 12.659 0 0 0 10.0436 0 0 0 0 0 0 Q9BT25 HAUS8_HUMAN HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) HAUS8 HICE1 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; nuclear microtubule [GO:0005880]; spindle pole [GO:0000922] microtubule binding [GO:0008017] DSSGVGK;KPESTSFSAPRK;YLQYEKK 3 6.4 0.94079 -0.58669 0 0 0 7.11009 0 0 0 11.1536 0 0 0 10.066 Q9BT30 ALKB7_HUMAN "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)" ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564 Homo sapiens (Human) DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] ELEPELRRR 1 4.1 0.97598 -1.4703 0 0 0 0 0 0 0 0 0 0 10.2963 0 Q9BT40 INP5K_HUMAN "Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)" INPP5K PPS SKIP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of D-glucose transmembrane transport [GO:0010829]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of renal water transport [GO:2001153]; positive regulation of urine volume [GO:0035810]; protein localization to plasma membrane [GO:0072659]; regulation of glycogen biosynthetic process [GO:0005979]; ruffle assembly [GO:0097178] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; trans-Golgi network [GO:0005802] "inositol bisphosphate phosphatase activity [GO:0016312]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; lipid phosphatase activity [GO:0042577]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol trisphosphate phosphatase activity [GO:0034594]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; vasopressin receptor activity [GO:0005000]" KPAWTDRILWR;MDVLSPLSFIK 2 5.9 0.95299 -0.67737 12.2316 0 0 0 0 0 0 0 0 8.44315 0 0 Q9BT43 RPC7L_HUMAN DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) (RNA polymerase III 32 kDa beta subunit) (RPC32-beta) POLR3GL Homo sapiens (Human) transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] ITILLPKRPPK;QLPYFIRPAVPKRDVER;RLPRELK 3 16.1 0.97763 -1.5177 0 5.66687 0 5.16515 4.71072 9.89454 0 0 6.03699 5.20602 0 0 Q9BT49 THAP7_HUMAN THAP domain-containing protein 7 THAP7 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; general transcription initiation factor binding [GO:0140296]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphorylated histone binding [GO:0106153]; transcription corepressor binding [GO:0001222] HCSAAGCCTR;MPRHCSAAGCCTRDTR;QLQACKRR 3 7.8 0.96287 -1.0823 0 0 0 0 0 0 0 9.77075 0 0 8.50756 0 Q9BT67 NFIP1_HUMAN NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein) NDFIP1 N4WBP5 PSEC0192 PSEC0223 Homo sapiens (Human) "CD4-positive, alpha-beta T cell proliferation [GO:0035739]; intracellular iron ion homeostasis [GO:0006879]; metal ion transport [GO:0030001]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of lymphocyte differentiation [GO:0045619]; regulation of myeloid leukocyte differentiation [GO:0002761]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034]" cell cortex [GO:0005938]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] WW domain binding [GO:0050699] AEATIPLVPGRDEDFVGR;MPETFSNLPR 2 12.7 0.9644 -1.1173 0 0 0 9.37173 0 0 0 0 0 0 0 0 Q9BT78 CSN4_HUMAN COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) COPS4 CSN4 Homo sapiens (Human) protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021] deNEDDylase activity [GO:0019784] DERCQQLAAYGILEKMYLDR;DLAGKYRQILEK;IASQMITEGR 3 10.3 0.97586 -2.3091 0 0 0 0 0 0 14.9668 0 0 0 0 0 Q9BT88 SYT11_HUMAN Synaptotagmin-11 (Synaptotagmin XI) (SytXI) SYT11 KIAA0080 Homo sapiens (Human) autophagy [GO:0006914]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; establishment of vesicle localization [GO:0051650]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of cytokine production [GO:0001818]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of endocytosis [GO:0045806]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; plasma membrane repair [GO:0001778]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of defense response to bacterium [GO:1900424]; regulation of phagosome maturation [GO:1905162]; regulation of synaptic vesicle endocytosis [GO:1900242]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; early phagosome [GO:0032009]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; inhibitory synapse [GO:0060077]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] beta-tubulin binding [GO:0048487]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; SNARE binding [GO:0000149]; translation initiation factor binding [GO:0031369]; ubiquitin protein ligase binding [GO:0031625] EVCESPRKPVAKWHSLSEY;FIHMLKGISIYPETLSNK;GISIYPETLSNK 3 8.6 0.90903 -0.30918 0 0 0 0 0 0 9.78452 0 0 10.0254 0 0 Q9BT92 TCHP_HUMAN Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein) TCHP Homo sapiens (Human) apoptotic process [GO:0006915]; cell projection organization [GO:0030030]; negative regulation of cell growth [GO:0030308]; negative regulation of cilium assembly [GO:1902018] apical cortex [GO:0045179]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ALPTLPSYWCSQQRLNQQLAR;EAELQMLLREEAK;LQAEALLQQMEELKLK;RTQQIQEELEADRR;TQQIQEELEADR 5 12.9 0.973 -2.9469 11.0737 0 0 0 0 0 0 0 10.5888 0 0 10.2896 Q9BTA9 WAC_HUMAN WW domain-containing adapter protein with coiled-coil WAC KIAA1844 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] DAGDPSPPNKMLR;EWLEREQR;LSDGCHDR;NLRSLVR;NVHTHRVRER;VCEIQATLREQR 6 9 0.9746 -3.9142 9.61541 10.6596 0 9.84387 0 0 0 0 0 0 7.2031 8.15896 Q9BTC0 DIDO1_HUMAN Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) DIDO1 C20orf158 DATF1 KIAA0333 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819] metal ion binding [GO:0046872]; RNA binding [GO:0003723] AANPSGK;EMFNLFQVTDNRYKSK;GIQSRLR;VEQFLTIARR;VTVDDLPNR 5 2.2 0.97904 -1.962 0 0 7.99384 3.8529 10.0014 9.91974 7.71959 0 0 0 0 0 Q9BTC8 MTA3_HUMAN Metastasis-associated protein MTA3 MTA3 KIAA1266 Homo sapiens (Human) chromatin remodeling [GO:0006338]; G2/M transition of mitotic cell cycle [GO:0000086]; granulosa cell proliferation [GO:1990739]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of granulosa cell proliferation [GO:1904197]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] ACESCYATQSHQWYSWGPPNMQCRLCAICWLYWK;AVGTFAR;FARQVCKNTLR;NTLRLRQAAR;QIDQFLVVARAVGTFAR;RMLTTPNHTSLSILGK 6 14.1 0.92118 -0.44615 0 10.8542 0 0 9.70091 0 13.7081 0 12.5579 8.97401 0 0 Q9BTD3 TM121_HUMAN Transmembrane protein 121 TMEM121 HHOLE Homo sapiens (Human) membrane [GO:0016020] ALTLLLSVCVPGLFLLLVALDR 1 6.9 0.89785 -0.23219 0 0 0 0 0 0 0 0 7.57698 0 0 0 Q9BTD8 RBM42_HUMAN RNA-binding protein 42 (RNA-binding motif protein 42) RBM42 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EAMFLRR 1 1.5 0.78316 0.028577 0 0 0 9.95553 0 0 0 0 0 9.18799 10.109 0 Q9BTE1 DCTN5_HUMAN Dynactin subunit 5 (Dynactin subunit p25) DCTN5 Homo sapiens (Human) aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; ventricular septum development [GO:0003281] centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] TIVMNDCIIR 1 5.5 0.89498 -0.24268 0 0 0 0 0 0 0 0 0 0 0 7.69112 Q9BTE3 MCMBP_HUMAN Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) MCMBP C10orf119 Homo sapiens (Human) cell division [GO:0051301]; DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062] cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] DVLPLGK 1 1.1 0.94204 -0.59665 0 0 0 0 9.49653 0 0 0 0 0 0 0 Q9BTF0 THUM2_HUMAN THUMP domain-containing protein 2 THUMPD2 C2orf8 Homo sapiens (Human) tRNA methylation [GO:0030488] RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423] LFLLIKKQFPLIISSVSK;TASTSFEASNHK 2 6 0.91855 -0.403 0 3.07762 0 0 0 8.2384 0 0 0 0 0 0 Q9BTM9 URM1_HUMAN Ubiquitin-related modifier 1 URM1 C9orf74 Homo sapiens (Human) protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; nucleus [GO:0005634] protein tag activity [GO:0031386]; sulfur carrier activity [GO:0097163] NLLIWIKKNLLK 1 8.2 0.87084 -0.095851 0 0 0 0 0 0 0 6.9514 0 0 0 0 Q9BTN0 LRFN3_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4) LRFN3 SALM4 UNQ5865/PRO34192 Homo sapiens (Human) regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; synaptic membrane adhesion [GO:0099560] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787] AVGDPEPRVR 1 1.6 0.68495 0.16281 7.80639 0 0 0 0 0 9.9379 0 0 0 0 0 Q9BTP6 ZBED2_HUMAN Zinc finger BED domain-containing protein 2 ZBED2 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of keratinocyte differentiation [GO:0045618] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" AEKEACQREK 1 4.6 0.97444 -1.4251 0 0 0 0 0 0 0 9.6764 0 0 0 0 Q9BTP7 FAP24_HUMAN Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa) FAAP24 C19orf40 Homo sapiens (Human) interstrand cross-link repair [GO:0036297] chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677] TVQQIPGVGK 1 4.7 0.89868 -0.23381 0 0 0 0 10.1312 0 0 0 0 0 0 0 Q9BTT6 LRRC1_HUMAN Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) LRRC1 LANO Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATPHPGELK;LLHLPLSLTALKLK;NLLCLDVSENRLER 3 7.1 0.96539 -1.2128 0 0 0 7.15816 0 0 0 0 0 0 0 9.87751 Q9BTU6 P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) PI4K2A Homo sapiens (Human) endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; growing cell tip [GO:0035838]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; trans-Golgi network [GO:0005802] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; AP-3 adaptor complex binding [GO:0035651]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287] QLLLQFERLVVLDYIIR;QLLLQFERLVVLDYIIRNTDR;VGSFQLFVEGYKDADYWLR;VPFSQEIK 4 10 0.94696 -0.65979 8.88102 0 0 0 0 0 5.96479 0 0 0 0 0 Q9BTV4 TMM43_HUMAN Transmembrane protein 43 (Protein LUMA) TMEM43 UNQ2564/PRO6244 Homo sapiens (Human) innate immune response [GO:0045087]; lipid metabolic process [GO:0006629]; nuclear membrane organization [GO:0071763] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] LEDPHVDIIR;LRRHVEMYQWVETEESR;QRGDQLVPFSTK;TSSQPGFLER 4 12.2 0.96521 -1.2198 14.6593 0 0 0 0 0 0 11.4557 0 0 7.17303 0 Q9BTV5 FSD1_HUMAN Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND) FSD1 GLFND MIR1 VLP27 Homo sapiens (Human) cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle organization [GO:0060236] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] VQEDLEAEFQSLFSLLEELK 1 4 0.85105 -0.074827 0 0 10.1109 6.04978 0 0 0 0 0 7.89451 7.12112 0 Q9BTV6 DPH7_HUMAN Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (WD repeat-containing protein 85) DPH7 C9orf112 WDR85 Homo sapiens (Human) protein histidyl modification to diphthamide [GO:0017183] cytoplasm [GO:0005737] diphthine methylesterase activity [GO:0061685] AGDQPLK 1 1.5 0.93359 -0.50251 0 8.92591 8.65721 0 0 0 0 0 0 0 0 0 Q9BTV7 CABL2_HUMAN CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) CABLES2 C20orf150 Homo sapiens (Human) cell division [GO:0051301]; regulation of cell cycle [GO:0051726] ISSDLRKSGVTQLIDK;LTLSKIR 2 4.8 0.98123 -1.7091 0 0 0 0 0 0 10.1013 0 0 0 9.9269 0 Q9BTW9 TBCD_HUMAN Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) TBCD KIAA0988 SSD1 TFCD PP1096 Homo sapiens (Human) adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis involved in neuron differentiation [GO:0048667]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874] beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087] LVQRLGLTFLKPKVAAWR 1 1.5 0.57729 0.18107 0 0 5.30393 0 0 0 0 0 0 0 0 0 Q9BTX1 NDC1_HUMAN Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) NDC1 TMEM48 Homo sapiens (Human) homologous chromosome pairing at meiosis [GO:0007129]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore transmembrane ring [GO:0070762]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674]; structural constituent of nuclear pore [GO:0017056] FRRSLLLLVK;GLHSGCFFRCPNAYLGIR;RSVALSSSIIYR;SRDILWR 4 8.7 0.93667 -0.55555 0 0 0 0 0 11.0347 0 0 0 1.42094 7.39103 0 Q9BTY2 FUCO2_HUMAN Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617] azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] alpha-L-fucosidase activity [GO:0004560] ELEVAIRNRTDLR;QLPAWFDQAK 2 4.9 0.98074 -1.6599 0 0 0 0 0 9.24267 0 0 0 0 0 0 Q9BTY7 HGH1_HUMAN Protein HGH1 homolog HGH1 C8orf30A C8orf30B FAM203A FAM203B Homo sapiens (Human) KMLVEAIMLLTATAPGR 1 4.4 0.60695 0.17653 0 0 0 4.31933 0 0 0 0 0 0 0 0 Q9BU02 THTPA_HUMAN Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) THTPA Homo sapiens (Human) dephosphorylation [GO:0016311]; generation of precursor metabolites and energy [GO:0006091]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772] cytosol [GO:0005829] hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333] LSSMLGVPAQETAPAK 1 7 0.7858 0.029217 0 12.6869 0 0 0 0 0 0 0 0 0 0 Q9BU19 ZN692_HUMAN Zinc finger protein 692 (AICAR responsive element binding protein) ZNF692 AREBP ZFP692 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EGETPPAPAALSSPLAVPALSASSLSSR;FEKPDSVAAHRSK 2 7.9 0.93682 -0.56646 0 6.38695 5.04776 0 9.6173 0 0 0 0 0 0 0 Q9BU19 ZN692_HUMAN Zinc finger protein 692 (AICAR responsive element binding protein) ZNF692 AREBP ZFP692 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LGFSLHSQLAKFLLDRACPAALFHPQVSHFTR 1 33.3 0.61416 0.17447 6.29888 0 0 0 0 0 6.5445 0 7.2485 0 0 0 Q9BU20 CPLN2_HUMAN Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) CPLANE2 C1orf89 RSG1 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cranial skeletal system development [GO:1904888]; endocardial cushion fusion [GO:0003274]; exocytosis [GO:0006887]; limb development [GO:0060173]; protein localization [GO:0008104]; protein processing [GO:0016485]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of smoothened signaling pathway [GO:0008589]; regulation of vesicle fusion [GO:0031338]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ASFEDLPGQLAR 1 4.7 0.89739 -0.23815 0 0 0 0 0 0 0 0 0 9.87957 0 0 Q9BU23 LMF2_HUMAN Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) LMF2 TMEM112B TMEM153 Homo sapiens (Human) protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] LMFASGVVK;YPFHKQPPTYVRAQR 2 3.4 0.97591 -1.462 0 0 0 9.46569 0 0 0 0 11.4276 0 0 0 Q9BU64 CENPO_HUMAN Centromere protein O (CENP-O) (Interphase centromere complex protein 36) CENPO ICEN36 MCM21R Homo sapiens (Human) centromere complex assembly [GO:0034508]; chromosome segregation [GO:0007059] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; Mis6-Sim4 complex [GO:0031511]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LDPGGQSFPFCAR;LENVKAILQAYHFTGLSGK 2 10.7 0.88213 -0.16395 0 8.8842 0 0 0 0 0 8.01748 0 6.53308 0 0 Q9BU70 TRMO_HUMAN tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) TRMO C9orf156 HSPC219 Homo sapiens (Human) tRNA methylation [GO:0030488] tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity [GO:0089715] EIAVDFGLESR 1 2.5 0.93371 -0.49872 0 0 0 0 0 0 10.5788 0 0 0 0 0 Q9BU76 MMTA2_HUMAN Multiple myeloma tumor-associated protein 2 (hMMTAG2) MMTAG2 C1orf35 Homo sapiens (Human) extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] RNA binding [GO:0003723] EHRRPAEATSSPTSPERPR;GGQDQFNWEDVK;GGQDQFNWEDVKTDKQR;HHHHDSDSNSPCCKR;VAMSREDK 5 22.4 0.95486 -0.83521 0 0 0 0 0 0 0 0 10.2309 0 0 0 Q9BU76 MMTA2_HUMAN Multiple myeloma tumor-associated protein 2 (hMMTAG2) MMTAG2 C1orf35 Homo sapiens (Human) extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] RNA binding [GO:0003723] EAAKLGLSVFTVIPRPA;GGQDQFNWEDVK;GGQDQFNWEDVKTDKQR;LGLSVFTVIPRPA;VAMSREDK 5 27.1 0.96672 -1.3006 7.51381 0 0 13.7673 12.7372 12.8455 13.272 13.2988 13.2808 14.4735 13.8994 14.0775 Q9BUA3 SPNDC_HUMAN Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) SPINDOC C11orf84 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of protein ADP-ribosylation [GO:0010835] nucleus [GO:0005634]; site of DNA damage [GO:0090734] GTLDLQVIR 1 2.4 0.90959 -0.31156 0 0 0 0 0 0 10.2939 0 0 0 0 0 Q9BUB4 ADAT1_HUMAN tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) ADAT1 Homo sapiens (Human) tRNA processing [GO:0008033] adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; tRNA-specific adenosine-37 deaminase activity [GO:0043829] ILQSDLLFEQSRSAVQAKR;QVFGSWIRNPPDYHQFK;VIDVYRTGAK 3 9.2 0.97618 -1.4755 0 0 0 0 9.19849 0 0 0 0 0 8.89724 0 Q9BUB7 TMM70_HUMAN "Transmembrane protein 70, mitochondrial" TMEM70 Homo sapiens (Human) mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260] mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] mitochondrial proton-transporting ATP synthase complex binding [GO:0140260] AQIPVYWEGYVR;LIYTGNMAR;MLFLALGSPWAVELPLCGRR 3 15.8 0.95249 -0.68165 0 0 4.14706 0 0 0 0 0 0 10.7898 0 0 Q9BUE0 MED18_HUMAN Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b) MED18 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] GIMKIMVYK 1 4.3 0.9017 -0.26382 0 0 0 0 0 0 0 8.37156 0 0 0 0 Q9BUF5 TBB6_HUMAN Tubulin beta-6 chain (Tubulin beta class V) TUBB6 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] AALVDLEPGTMDSVR;ALTVPELTQQMFDAR;FPGQLNADLRK;LAVNMVPFPR;LHFFMPGFAPLTSR;NSSYFVEWIPNNVK;YLTVATVFR 7 19.7 0 6.4035 0 0 0 0 0 0 11.2732 11.2577 0 10.0653 9.97484 11.0285 Q9BUG6 ZSA5A_HUMAN Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) ZSCAN5A ZNF495 ZSCAN5 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AKEGKDPPK;EYIVQDSDIEMAEAPSSVR;SIDVTGDPK;VFTYRGSLKEHQR;VPALSRRQGEDFLLHK 5 13.3 0.97547 -3.4349 0 0 0 0 0 9.42385 6.86171 3.55716 0 9.84905 7.14252 0 Q9BUH8 BEGIN_HUMAN Brain-enriched guanylate kinase-associated protein BEGAIN KIAA1446 Homo sapiens (Human) evoked excitatory postsynaptic potential [GO:0098817] cytoplasm [GO:0005737]; membrane [GO:0016020]; postsynapse [GO:0098794]; synapse [GO:0045202] TGGSGLSRKDSLTK;YYGGAGGSPGKK 2 4.4 0.74596 0.093682 0 0 0 9.13668 0 0 0 0 0 0 0 10.5806 Q9BUI4 RPC3_HUMAN DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62) POLR3C Homo sapiens (Human) defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697] GVVEYEAQCSR;LTMSAVVKKVADR;MLLHRCYK;RSSDEDAAGEPK 4 8.2 0.95305 -0.76232 0 9.52521 0 0 0 0 0 0 11.1455 0 0 0 Q9BUJ2 HNRL1_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) HNRNPUL1 E1BAP5 HNRPUL1 Homo sapiens (Human) response to virus [GO:0009615]; RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] enzyme binding [GO:0019899]; RNA binding [GO:0003723] EALGGQALYPHVLVK;GPPGGNR;LVRQYNEEGR 3 3.7 0.87667 -0.13109 0 0 7.09529 0 8.57618 0 0 10.8274 0 8.26515 0 0 Q9BUK6 MSTO1_HUMAN Protein misato homolog 1 MSTO1 LST005 SLTP005 Homo sapiens (Human) mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fusion [GO:0010636] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] DLTKLDLR 1 1.4 0.91293 -0.33804 0 0 0 0 0 0 0 0 0 8.87759 0 0 Q9BUL8 PDC10_HUMAN Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) PDCD10 CCM3 TFAR15 Homo sapiens (Human) "angiogenesis [GO:0001525]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelium development [GO:0003158]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of gene expression [GO:0010629]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; wound healing, spreading of cells [GO:0044319]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901] SFSDTLKTYFK;YSKSFSDTLK 2 6.6 0.91564 -0.36614 0 0 0 0 0 0 8.03254 0 7.87351 0 0 9.70769 Q9BUN1 MENT_HUMAN Protein MENT (Methylated in normal thymocytes protein) MENT C1orf56 UNQ547/PRO1104 Homo sapiens (Human) regulation of cell population proliferation [GO:0042127] extracellular region [GO:0005576] ELPSATPNTAGSSSTR;FIANSQEPEIR;SGKLHGLSGR 3 10.9 0.95849 -1.0018 11.5318 11.1635 0 10.9247 7.80639 0 0 0 0 10.5812 10.5064 0 Q9BUN5 CC28B_HUMAN Coiled-coil domain-containing protein 28B CCDC28B Homo sapiens (Human) cilium assembly [GO:0060271] centrosome [GO:0005813]; cytoplasm [GO:0005737] ECSFEQLEHVREMQEK 1 8 0.91814 -0.43518 0 0 0 0 0 0 0 5.2581 0 0 0 0 Q9BUQ8 DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) DDX23 Homo sapiens (Human) "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; R-loop processing [GO:0062176]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DILVATDVAGR;EQEEARLR;FLSKAEREAEALK;LIDVLENR;MAGELADK;MLANFESGK 6 7 0.972 -2.8234 0 0 7.53605 0 0 8.21989 0 0 0 11.0023 0 0 Q9BUR5 MIC26_HUMAN MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) APOO FAM121B MIC23 MIC26 My025 UNQ1866/PRO4302 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; lipid transport [GO:0006869] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; very-low-density lipoprotein particle [GO:0034361] VDELSLYSVPEGQSK 1 7.6 0.84817 -0.06721 0 0 0 0 0 0 0 0 0 11.2592 0 0 Q9BUT1 DHRS6_HUMAN Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) BDH2 DHRS6 SDR15C1 UNQ6308/PRO20933 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]" GNPEEAR;GVVNRCVYSTTKAAVIGLTK 2 11 0.9337 -0.50593 0 0 9.35149 0 0 0 0 0 0 0 0 0 Q9BUT1 DHRS6_HUMAN Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) BDH2 DHRS6 SDR15C1 UNQ6308/PRO20933 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]" CSYTHIIK 1 4.6 0.74606 0.094974 12.5866 11.6785 11.8278 0 0 9.64093 12.0186 0 0 0 0 11.1011 Q9BUU2 MET22_HUMAN Methyltransferase-like protein 22 (EC 2.1.1.-) METTL22 C16orf68 LP8272 Homo sapiens (Human) protein methylation [GO:0006479] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279] LNFTLRHLDVTCEAYDHFR 1 4.7 0.9184 -0.43639 0 0 0 0 0 0 0 0 0 8.31238 0 0 Q9BUY5 ZN426_HUMAN Zinc finger protein 426 ZNF426 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFTQYSGLSMHVR;SLRRHEQIH 2 4 0.97553 -1.4723 0 0 0 0 0 0 8.32125 0 0 0 0 0 Q9BUY7 EFC11_HUMAN EF-hand calcium-binding domain-containing protein 11 EFCAB11 C14orf143 Homo sapiens (Human) calcium ion binding [GO:0005509] GFLTLEDFKKAFR;TVLEVFR;TVLEVFREVDR 3 14.7 0.9546 -0.90767 0 0 0 0 7.32112 0 7.70998 0 12.0328 0 7.96694 0 Q9BUZ4 TRAF4_HUMAN TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) TRAF4 CART1 MLN62 RNF83 Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; transferase activity [GO:0016740]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270] DLPAHLQHDCPK;ELEELSVGSDGVLIWK;VLPGAFDNLLEWPFARR 3 9.6 0.60333 0.17794 0 0 0 9.31705 0 0 0 10.1513 11.596 5.41664 0 0 Q9BUZ4 TRAF4_HUMAN TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) TRAF4 CART1 MLN62 RNF83 Homo sapiens (Human) apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; transferase activity [GO:0016740]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270] CEFCGCDFSGEAYESHESSLGFGYPK;DLPAHLQHDCPK 2 19.2 0.71208 0.14778 0 10.1722 0 0 0 0 0 0 0 0 0 0 Q9BV10 ALG12_HUMAN "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)" ALG12 PP14673 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020] "alpha-1,6-mannosyltransferase activity [GO:0000009]; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [GO:0052917]; mannosyltransferase activity [GO:0000030]" GVLGLGVIFGLWTLQKEVR;TLPNVLALPVVLLALAAWLR 2 8 0.8817 -0.15698 0 0 0 0 0 0 9.3238 0 11.6583 0 0 0 Q9BV20 MTNA_HUMAN Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) MRI1 MRDI UNQ6390/PRO21135 Homo sapiens (Human) L-methionine salvage from methylthioadenosine [GO:0019509] cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523] SLHSLGR 1 1.9 0.9097 -0.31567 0 9.43634 0 0 0 0 0 0 0 0 0 0 Q9BV23 ABHD6_HUMAN Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) ABHD6 Homo sapiens (Human) acylglycerol catabolic process [GO:0046464]; arachidonate metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178] AMPA glutamate receptor complex [GO:0032281]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] monoacylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620] IYYWYWRR;KTAKLIIDFLASVHNTDNNK 2 8.3 0.98085 -1.7272 0 0 0 0 0 0 0 0 10.1563 0 0 0 Q9BV29 CCD32_HUMAN Coiled-coil domain-containing protein 32 CCDC32 C15orf57 Homo sapiens (Human) cilium organization [GO:0044782]; head development [GO:0060322]; regulation of clathrin-dependent endocytosis [GO:2000369] clathrin-coated pit [GO:0005905] KECWDRFLQEK 1 5.9 0.86564 -0.089434 0 0 0 5.73739 0 0 0 0 0 0 0 0 Q9BV35 SCMC3_HUMAN Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23) SLC25A23 APC2 MCSC2 SCAMC3 Homo sapiens (Human) adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cellular hyperosmotic salinity response [GO:1900069]; regulation of oxidative phosphorylation [GO:0002082]; regulation of sequestering of calcium ion [GO:0051282]; renal system process [GO:0003014] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509] ILEREGPRAFYR;LTGMWWK;QEKLTGMWWK 3 4.7 0.98022 -2.0405 0 12.9367 0 0 0 0 0 10.8354 0 0 0 0 Q9BV36 MELPH_HUMAN Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) MLPH SLAC2A Homo sapiens (Human) intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] DKSVGPLPQADPEVSDIESR;IAALRAAGLTVKPSGKPR;LGKRPEDPNADPSSEAK;QCLECGLFTCKSCGR 4 14.6 0.97316 -2.4883 0 0 6.30296 7.35279 0 0 0 0 0 3.89113 9.37567 0 Q9BV38 WDR18_HUMAN WD repeat-containing protein 18 WDR18 Homo sapiens (Human) DNA-templated DNA replication [GO:0006261]; rRNA processing [GO:0006364] dynein axonemal particle [GO:0120293]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; rixosome complex [GO:0120330] KDQLQQK;VTELEDEVR 2 3.7 0.95492 -0.83373 0 0 0 0 0 9.07759 0 0 0 8.42038 0 0 Q9BV40 VAMP8_HUMAN Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) VAMP8 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; defense response to virus [GO:0051607]; mucus secretion [GO:0070254]; negative regulation of secretion by cell [GO:1903531]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; regulation of protein localization to plasma membrane [GO:1903076]; SNARE complex assembly [GO:0035493]; symbiont entry into host cell [GO:0046718]; vesicle fusion [GO:0006906] azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mucin granule [GO:0098594]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]; zymogen granule membrane [GO:0042589] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] NVKMIVLICVIVFIIILFIVLFATGAFS 1 28 0.84077 -0.048763 0 0 0 0 0 0 0 0 0 7.2406 0 0 Q9BV44 THUM3_HUMAN tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) THUMPD3 Homo sapiens (Human) tRNA methylation [GO:0030488] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730] tRNA (guanine(6)-N2)-methyltransferase activity [GO:0160117]; tRNA (guanine(7)-N2)-methyltransferase activity [GO:0160118]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA binding [GO:0000049] AVLLTQDTKCFTK;NWNLYPACLREMSR;RNITHFGPTTLRSTLAYGMLR;VTCNRAGEK 4 11.2 0.97663 -2.1895 9.42798 0 0 0 0 8.8857 0 8.77568 6.12387 0 0 0 Q9BV57 MTND_HUMAN Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L) ADI1 MTCBP1 HMFT1638 Homo sapiens (Human) L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]; oxidoreductase activity [GO:0016491] DKLPNYEEK;YILDGSGYFDVR 2 11.7 0.98017 -1.5606 0 10.1371 5.7426 0 0 8.13283 0 0 0 0 0 0 Q9BV73 CP250_HUMAN Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) CEP250 CEP2 CNAP1 Homo sapiens (Human) centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; mitotic cell cycle [GO:0000278]; non-motile cilium assembly [GO:1905515]; positive regulation of protein localization to centrosome [GO:1904781]; protein localization [GO:0008104]; protein localization to centrosome [GO:0071539]; protein localization to organelle [GO:0033365]; regulation of centriole-centriole cohesion [GO:0030997] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; protein-containing complex [GO:0032991] protein domain specific binding [GO:0019904] EAHERSQELIQLK;EIEWREK;ELKEAARQHR;LELDTER;MEAQGERELLQAAK;QAVQDLR;QDMQEAQGEQK;RLEEELAVEGRR;TALEQQKAAHEKEVNQLR;TEVADLR;VQALEEVLGDLR 11 4.8 0.97496 -4.1344 6.98231 10.5128 13.2402 11.0421 0 7.39025 7.77992 8.01363 12.2242 4.55943 6.50917 0 Q9BV94 EDEM2_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 2 EDEM2 C20orf31 C20orf49 UNQ573/PRO1135 Homo sapiens (Human) "carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; viral protein processing [GO:0019082]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" AIRNYTR;KLMAMFLEYNKAIR;LKEEQWEVEDLMREFYSLK;LMAMFLEYNKAIRNYTR 4 6.4 0.89598 -0.24435 0 0 0 0 0 0 0 0 7.0881 0 4.63593 13.2329 Q9BV97 ZN747_HUMAN Zinc finger protein 747 ZNF747 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] VHTGEKPYRCPQCGR 1 4.5 0.91545 -0.43392 0 8.78992 0 0 0 0 0 0 0 0 0 0 Q9BVA0 KTNB1_HUMAN Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 Homo sapiens (Human) cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922] ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982] AEIQNAEDYNEIFQPK;ASDFLPAVK;GCVFRYR;LDLCTTVLPQIEK;NLDTVRAVWTMGDIK 5 9.2 0.97895 -2.0516 5.22982 0 0 0 10.8833 0 0 0 0 0 11.741 0 Q9BVC6 TM109_HUMAN Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) TMEM109 Homo sapiens (Human) cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of programmed cell death [GO:0043069] extracellular exosome [GO:0070062]; monoatomic ion channel complex [GO:0034702]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017] voltage-gated monoatomic cation channel activity [GO:0022843] ALLLLALLILYALLSR;EAPVDVLTQIGR;LTGSRASGAQLEAK;QVEELRWR 4 20.6 0.25415 0.27083 12.1395 0 0 8.58913 0 0 0 12.2086 5.24698 0 8.99738 0 Q9BVG3 TRI62_HUMAN E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62) TRIM62 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K27-linked ubiquitination [GO:0044314]; regulation of viral entry into host cell [GO:0046596]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ERQKAMLEELEADTAR;GSIQIQPSR;LHRLLRER;SLRTTIGEAFER;VQRYSQQLR 5 10.9 0.97425 -1.423 0 9.4886 5.40643 0 0 6.83302 0 8.36203 0 9.36803 0 0 Q9BVG4 PBDC1_HUMAN Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) PBDC1 CXorf26 Homo sapiens (Human) GVNNGGEK 1 3.4 0.91586 -0.39033 0 0 0 0 0 0 0 0 0 10.1224 0 0 Q9BVG8 KIFC3_HUMAN Kinesin-like protein KIFC3 KIFC3 Homo sapiens (Human) epithelial cell-cell adhesion [GO:0090136]; Golgi organization [GO:0007030]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; visual perception [GO:0007601]; zonula adherens maintenance [GO:0045218] centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; zonula adherens [GO:0005915] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EAQHINK;EPQEKLEIR;NQHLQEQVAMQRQVLK;RTWNLGATPSLR 4 5.3 0.9803 -1.7961 10.189 11.3245 0 5.72942 9.16614 0 0 0 0 0 0 0 Q9BVI0 PHF20_HUMAN PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) PHF20 C20orf104 GLEA2 HCA58 NZF TZP Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LDKNSSQEKSK;SLSSSPDKREK 2 2.2 0.97511 -2.3793 0 0 0 0 0 0 0 0 0 0 9.35255 0 Q9BVI0 PHF20_HUMAN PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) PHF20 C20orf104 GLEA2 HCA58 NZF TZP Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LSNFATNNIGTEKK;SLSSSPDKREK 2 9.2 0.65188 0.17067 0 0 0 0 8.89779 0 0 0 0 0 0 0 Q9BVI4 NOC4L_HUMAN Nucleolar complex protein 4 homolog (NOC4 protein homolog) (NOC4-like protein) (Nucleolar complex-associated protein 4-like protein) NOC4L Homo sapiens (Human) rRNA processing [GO:0006364] Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] LALTAPPEALLMVLPFICNLLR;VFQAMWLSFLK 2 6.4 0.84756 -0.069165 6.51953 0 0 0 0 0 0 0 0 0 0 10.3615 Q9BVJ6 UT14A_HUMAN U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) UTP14A SDCCAG16 Homo sapiens (Human) rRNA processing [GO:0006364] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] AELQRARALQSYYEAK;ALQSYYEAKARR;APEGPPR 3 3.4 0.98109 -1.7767 8.97779 0 2.43026 0 0 0 12.6213 10.7396 0 12.1108 12.0959 0 Q9BVJ7 DUS23_HUMAN Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z) DUSP23 LDP3 VHZ Homo sapiens (Human) cilium assembly [GO:0060271]; dephosphorylation [GO:0016311] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" MGVQPPNFSWVLPGR 1 10 0.89334 -0.22622 0 0 0 8.59615 0 0 0 0 0 0 0 0 Q9BVK2 ALG8_HUMAN "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553] "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042283]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]" FLDPNNIPK;HMEGAFLFAVLLHFKHIYLYVAPAYGVYLLR 2 7.6 0.94515 -0.65 0 11.1259 0 0 0 0 0 0 0 0 0 0 Q9BVK6 TMED9_HUMAN Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) TMED9 GP25L2 Homo sapiens (Human) COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of organelle organization [GO:0010638] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133] syntaxin binding [GO:0019905] VLWWSILQTLILVAIGVWQMR 1 8.9 0.65505 0.16939 0 0 0 0 8.77482 0 0 0 0 0 8.0359 0 Q9BVK8 TM147_HUMAN BOS complex subunit TMEM147 (Protein NIFIE 14) (Transmembrane protein 147) TMEM147 Homo sapiens (Human) multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein localization to nuclear inner membrane [GO:0036228] endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ribosome binding [GO:0043022] MTLFHFGNCFALAYFPYFITYK 1 9.8 0.67827 0.1655 0 0 0 0 0 0 0 0 0 0 0 8.36405 Q9BVL2 NUP58_HUMAN Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) NUP58 KIAA0410 NUPL1 Homo sapiens (Human) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306] nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056] QVQEEISRMSSKAMLK 1 2.7 0.41264 0.20018 0 0 0 0 0 0 0 10.4589 0 0 0 0 Q9BVM2 DPCD_HUMAN Protein DPCD DPCD Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; lateral ventricle development [GO:0021670]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] extracellular region [GO:0005576]; nucleus [GO:0005634] CIIVRTTNKK 1 4.9 0.97716 -1.4986 0 0 0 10.8367 0 0 0 0 0 0 0 0 Q9BVN2 RUSC1_HUMAN AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) RUSC1 NESCA Homo sapiens (Human) protein polyubiquitination [GO:0000209] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] actin binding [GO:0003779] AEQDLPTSELLEADDGK;IDGGWRSDVSEEPVPHR;SSPWSVVEASVKPGSSTR 3 5.8 0.95502 -0.96536 11.4908 0 0 0 11.4678 0 0 0 10.0984 0 0 0 Q9BVP2 GNL3_HUMAN Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) GNL3 E2IG3 NS Homo sapiens (Human) "positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell population proliferation [GO:0042127]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]" chromosome [GO:0005694]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634] GTP binding [GO:0005525]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] DIHEELPKR;EALLREAELR;EFGLCKTENK;KLYCQELK;LVLILNKSDLVPK 5 9.1 0.97399 -2.4266 0 10.7497 0 2.90893 8.55286 4.06273 8.89984 0 9.20562 0 0 0 Q9BVQ7 AFG2B_HUMAN ATPase family gene 2 protein homolog B (EC 3.6.4.10) (AFG2 AAA ATPase homolog B) (Ribosome biogenesis protein SPATA5L1) (Spermatogenesis-associated protein 5-like protein 1) AFG2B SPATA5L1 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275] GVLLYGPPGCAK;RSLSLNRLLLVPCPPLR 2 3.9 0.91259 -0.3218 0 0 4.72083 0 9.30695 0 0 0 0 0 0 0 Q9BVR0 HRC23_HUMAN Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ALFSHQDK;IIREPRK;RMNSVCEKENTNATASN;SVVDVCR 4 3.4 0.98084 -1.7423 0 0 2.76201 10.0534 0 0 0 0 9.06628 0 0 0 Q9BVS4 RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) RIOK2 RIO2 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LSAMKEFAYMK;RENMQNIKSSLEAASFWGE 2 5.4 0.96424 -1.2077 0 0 0 0 0 0 0 0 12.7062 0 0 9.57209 Q9BVS5 TR61B_HUMAN "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)" TRMT61B Homo sapiens (Human) mitochondrial tRNA processing [GO:0090646]; mRNA processing [GO:0006397]; tRNA methylation [GO:0030488] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tRNA (m1A) methyltransferase complex [GO:0031515] mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; rRNA (adenine) methyltransferase activity [GO:0016433]; tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] DHHDLAK 1 1.5 0.90862 -0.30929 0 0 0 0 8.49669 0 0 0 0 0 0 0 Q9BVT8 TMUB1_HUMAN Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] TMUB1 C7orf21 DULP HOPS SB144 UNQ763/PRO1555 Homo sapiens (Human) ERAD pathway [GO:0036503] centrosome [GO:0005813]; nucleolus [GO:0005730]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037] FLNDSEQVAR 1 4.1 0.80553 0.014066 0 0 0 5.13967 0 0 0 0 0 0 0 0 Q9BVV2 FND11_HUMAN Fibronectin type III domain-containing protein 11 FNDC11 C20orf195 Homo sapiens (Human) FTIKRAETSTLVYEPWR;NLLPNRSYKFTIK 2 8.2 0.96389 -1.1854 0 12.6058 0 0 0 0 11.539 9.92701 0 0 0 0 Q9BVV6 TALD3_HUMAN Protein TALPID3 KIAA0586 TALPID3 Homo sapiens (Human) cilium assembly [GO:0060271]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917] ETNSMVQPKESLSMLK;SIRTQTDFYATKPKK;VTMQKSDDVLHDLGQK 3 3.1 0.98037 -1.6777 0 0 0 0 0 0 0 0 10.1179 11.0497 9.38427 0 Q9BVV7 TIM21_HUMAN "Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)" TIMM21 C18orf55 TIM21 HSPC154 Homo sapiens (Human) intracellular protein transport [GO:0006886]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein import into mitochondrial matrix [GO:0030150] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] QGTVYAQVK;SSAKRLLLPYIVLNK;TIWTQGPSPR 3 13.7 0.96673 -1.2779 0 0 0 0 10.1213 8.17453 0 0 0 0 0 0 Q9BVW5 TIPIN_HUMAN TIMELESS-interacting protein TIPIN Homo sapiens (Human) cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of cell population proliferation [GO:0008284]; regulation of nuclear cell cycle DNA replication [GO:0033262]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]; response to UV [GO:0009411] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298] DNA binding [GO:0003677] TVKRNIPK 1 2.7 0.8712 -0.095167 0 0 0 8.72277 0 0 0 0 0 0 0 0 Q9BW04 SARG_HUMAN Specifically androgen-regulated gene protein SARG C1orf116 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] LAPEPEK 1 1.2 0.90886 -0.30941 0 0 0 0 0 0 0 7.99435 0 0 0 0 Q9BW11 MAD3_HUMAN Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx) MXD3 BHLHC13 MAD3 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AWCLGVRPSCCGASSPARSTATR 1 5.9 0.94083 -0.60841 0 11.2271 0 0 0 0 0 0 13.7386 0 0 0 Q9BW19 KIFC1_HUMAN Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) KIFC1 HSET KNSL2 Homo sapiens (Human) cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307] centrosome [GO:0005813]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] CSTAIATGLK;GLMSQLEEK;KGQGGECEIR;LDPGLALGPGER;LSLSRSDER;RPLIKAPSQLPLSGSRLK 6 10.1 0.97188 -2.7007 0 9.10967 9.39626 8.60151 9.10056 0 0 0 0 9.52456 10.3874 10.8787 Q9BW27 NUP85_HUMAN Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1) NUP85 NUP75 PCNT1 Homo sapiens (Human) lamellipodium assembly [GO:0030032]; macrophage chemotaxis [GO:0048246]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; spindle [GO:0005819] structural constituent of nuclear pore [GO:0017056] VLRICEQR;VSLELHIERIPLNTEQK 2 3.8 0.97858 -1.9052 0 0 12.1235 0 0 0 12.4163 12.1479 0 0 0 0 Q9BW61 DDA1_HUMAN DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) DDA1 C19orf58 PCIA1 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] GLPVYNK 1 6.9 0.90897 -0.30969 0 0 0 0 0 0 0 0 8.10873 0 0 0 Q9BW66 CINP_HUMAN Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) CINP Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; ribosomal large subunit biogenesis [GO:0042273] nucleus [GO:0005634] preribosome binding [GO:1990275] LLEMYRKELLLK;VCLEYNEELEK 2 10.8 0.9763 -1.4796 0 11.1204 0 0 0 0 0 0 0 0 0 10.3417 Q9BW66 CINP_HUMAN Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) CINP Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; ribosomal large subunit biogenesis [GO:0042273] nucleus [GO:0005634] preribosome binding [GO:1990275] CTGRSCS;VCLEYNEELEK 2 15.3 0.68521 0.16314 0 0 0 0 0 0 0 0 0 5.96232 0 0 Q9BW71 HIRP3_HUMAN HIRA-interacting protein 3 HIRIP3 Homo sapiens (Human) chromatin organization [GO:0006325] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] H2A-H2B histone complex chaperone activity [GO:0000511] AELEALGMK 1 1.6 0.92948 -0.48542 0 0 0 0 0 10.4171 0 0 0 0 0 0 Q9BW85 YJU2_HUMAN Splicing factor YJU2 (Coiled-coil domain-containing protein 94) YJU2 CCDC94 Homo sapiens (Human) "generation of catalytic spliceosome for first transesterification step [GO:0000349]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; RNA splicing [GO:0008380]" nucleoplasm [GO:0005654]; U2-type catalytic step 1 spliceosome [GO:0071006] metal ion binding [GO:0046872] IPKLKLPK;QHRLSEEERR 2 5.6 0.97349 -1.4161 0 0 0 0 0 0 0 5.8658 0 8.6393 0 0 Q9BW92 SYTM_HUMAN "Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1)" TARS2 TARSL1 Homo sapiens (Human) mitochondrial threonyl-tRNA aminoacylation [GO:0070159]; threonyl-tRNA aminoacylation [GO:0006435] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; threonine-tRNA ligase activity [GO:0004829] MALYQRWR;SSGAPETLQR 2 2.5 0.95618 -0.99038 0 0 0 0 0 0 0 10.7437 0 0 0 0 Q9BWC9 CC106_HUMAN Coiled-coil domain-containing protein 106 CCDC106 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] LKSMSRAFEHHR;NSWLQKRIEDLEEER 2 9.6 0.96323 -1.0987 0 0 0 0 9.44371 9.02042 0 0 10.3406 7.68138 0 0 Q9BWD1 THIC_HUMAN "Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)" ACAT2 ACTL Homo sapiens (Human) fatty acid metabolic process [GO:0006631]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] acetyl-CoA C-acetyltransferase activity [GO:0003985] ELGLNPEK;IVSWSQVGVEPSIMGIGPIPAIK;MNAGSDPVVIVSAAR 3 11.6 0 2.7619 9.10331 7.61714 0 0 0 0 0 0 0 0 0 9.54034 Q9BWD3 RTL8A_HUMAN Retrotransposon Gag-like protein 8A (Mammalian retrotransposon derived protein 8A) RTL8A CXX1B FAM127B MAR8A Homo sapiens (Human) VQLMKALLAGPLRPAARR 1 15.9 0.56805 0.18216 0 0 0 8.08162 8.44535 7.99673 0 9.32483 8.5292 8.11447 0 0 Q9BWE0 REPI1_HUMAN DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) REPIN1 RIP60 ZNF464 Homo sapiens (Human) regulation of fatty acid transport [GO:2000191]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin insulator sequence binding [GO:0043035]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] FLRAHQR;SFAQWDQLVAHK 2 3.4 0.91529 -0.37013 0 0 0 0 0 0 0 10.1467 0 0 0 10.5053 Q9BWF2 TRAIP_HUMAN E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) TRAIP RNF206 TRIP Homo sapiens (Human) apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; replication fork processing [GO:0031297]; signal transduction [GO:0007165] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; site of DNA damage [GO:0090734] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LDTFLWS;SESSCSK 2 3 0.88064 -0.14954 0 0 0 0 8.92935 0 8.71143 8.55209 9.02528 0 5.06824 9.75709 Q9BWF3 RBM4_HUMAN RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) RBM4 RBM4A Homo sapiens (Human) "cap-independent translational initiation [GO:0002190]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; enteroendocrine cell differentiation [GO:0035883]; entrainment of circadian clock by photoperiod [GO:0043153]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; IRES-dependent translational initiation of linear mRNA [GO:0002192]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; pancreas development [GO:0031016]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA processing [GO:0006396]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cyclin binding [GO:0030332]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EATEQEIR;TAPGMGDQSGCYRCGK;VKLFIGNLPREATEQEIR 3 9.3 0.9632 -1.0967 0 0 0 0 6.25321 0 0 0 0 0 10.5544 0 Q9BWH2 FUND2_HUMAN FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6) FUNDC2 HCBP6 DC44 HCC3 PD03104 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; intracellular triglyceride homeostasis [GO:0035356]; regulation of platelet activation [GO:0010543] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" KSNQIPTEVR 1 5.3 0.64639 0.17145 0 0 0 0 0 0 10.3182 0 0 0 0 0 Q9BWH6 RPAP1_HUMAN RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) transcription by RNA polymerase II [GO:0006366] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleotidyltransferase activity [GO:0016779] DTQGKSATSGKR;EDEDEDEECPAGK;HSLESATRVLECPR;LLSRPEMWR;VLECPRLIETIVR 5 3.9 0.97886 -1.9907 0 12.7037 0 9.87381 7.63307 8.3302 0 0 9.47905 0 12.242 6.68636 Q9BWJ5 SF3B5_HUMAN Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) SF3B5 SF3B10 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; U2-type prespliceosome assembly [GO:1903241]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; splicing factor binding [GO:1990935] YIGTGHADTTK 1 12.8 0.89297 -0.21806 0 0 0 0 0 0 10.8605 10.8359 0 0 0 0 Q9BWK5 CYREN_HUMAN Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog) CYREN C7orf49 MRI Homo sapiens (Human) double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein localization to site of double-strand break [GO:1990166] cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] damaged DNA binding [GO:0003684] NVAPMKAPK 1 5.7 0.97629 -1.4865 0 0 0 0 0 0 0 0 0 10.5173 0 0 Q9BWL3 CA043_HUMAN Protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) C1orf43 NICE3 NS5ATP4 HSPC012 Homo sapiens (Human) in utero embryonic development [GO:0001701]; phagocytosis [GO:0006909] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739] AKHFLELK;ALIDTLLDGYETAR;GPHVPVGHNAPK 3 13.4 0.9725 -2.7274 0 12.4052 0 0 0 0 0 0 0 0 12.329 10.3921 Q9BWM5 ZN416_HUMAN Zinc finger protein 416 ZNF416 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGERPYVCGQCGKSFSQRATLIK 1 4.2 0.66333 0.16893 0 0 0 0 0 0 0 0 0 9.70622 0 0 Q9BWM7 SFXN3_HUMAN Sideroflexin-3 SFXN3 Homo sapiens (Human) mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] YVYDSAFHPDTGEK 1 4.4 0.78962 0.016971 0 0 0 4.79416 0 0 0 0 0 0 0 0 Q9BWN1 PRR14_HUMAN Proline-rich protein 14 PRR14 Homo sapiens (Human) muscle organ development [GO:0007517] chromosome [GO:0005694]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654] AAGGRTVPPNVAPSPDVGPLLQQR;DQVLSEPETK 2 5.8 0.94131 -0.60268 9.08058 0 0 0 0 0 0 0 0 0 0 0 Q9BWP8 COL11_HUMAN Collectin-11 (Collectin kidney protein 1) (CL-K1) COLEC11 UNQ596/PRO1182 Homo sapiens (Human) "antimicrobial humoral response [GO:0019730]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; developmental process [GO:0032502]; execution phase of apoptosis [GO:0097194]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]" collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370] calcium ion binding [GO:0005509]; calcium-dependent carbohydrate binding [GO:0120153]; D-mannose binding [GO:0005537]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492] CTSSFVEMGSQGDMGDK 1 6.3 0.6821 0.16528 0 0 0 0 0 0 0 0 0 3.86701 0 0 Q9BWS9 CHID1_HUMAN Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) CHID1 GL008 PSEC0104 SB139 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016] endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492] EPVVGAR;GREMFEVTGLHDVDQGWMR 2 6.6 0.94467 -0.63001 0 0 0 0 0 0 0 5.42186 0 0 0 0 Q9BWT3 PAPOG_HUMAN Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) PAPOLG PAP2 PAPG Homo sapiens (Human) mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] AVKLWAK;DPRTAEERK;ETFRLTLRAVK;LESTFKDPR;SDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAK;SDWSKLLEPPNFFQKYR;SLDIRCIRSLNGCR;VLVGNLER 8 14.9 0.97512 -4.1088 0 6.75462 0 8.58616 0 0 11.2407 10.3342 0 10.0703 0 10.996 Q9BWT6 MND1_HUMAN Meiotic nuclear division protein 1 homolog MND1 GAJ Homo sapiens (Human) homologous chromosome pairing at meiosis [GO:0007129]; reciprocal meiotic recombination [GO:0007131] nucleus [GO:0005634] double-stranded DNA binding [GO:0003690] EQLKAEVEK;YKDCDPQVVEEIR 2 10.7 0.95153 -0.69522 0 0 0 6.66661 0 0 0 0 6.14938 0 0 0 Q9BWT7 CAR10_HUMAN Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) CARD10 CARMA3 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein localization to nucleus [GO:1900182]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; immunological synapse [GO:0001772] signaling receptor complex adaptor activity [GO:0030159] DQYLQEMEDLR;LTPYLRQCR;TLLWNQGSTLPSLMDSK 3 3.6 0.96728 -1.3118 0 0 0 0 0 5.64224 0 0 14.82 14.514 12.0622 0 Q9BWU0 NADAP_HUMAN Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) SLC4A1AP HLC3 Homo sapiens (Human) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] mRNA binding [GO:0003729] AKNWEDEDFYDSDDDTFLDR;ELRKQQQILLEK;FKLKTGTVGK;INAGSQDDEMGCTWGMGEDAVEDDAEENPIVLEFQQER;LPVDDSTGK 5 12 0.97535 -3.4393 5.48935 0 0 10.3668 0 0 7.93487 8.46756 0 6.82209 0 0 Q9BWV3 CDAC1_HUMAN Cytidine and dCMP deaminase domain-containing protein 1 (EC 3.5.4.5) (Cytidine deaminase) (Testis development protein NYD-SP15) CDADC1 Homo sapiens (Human) cytidine deamination [GO:0009972]; DNA cytosine deamination [GO:0070383] cytoplasm [GO:0005737]; nucleus [GO:0005634] cytidine deaminase activity [GO:0004126]; dCMP deaminase activity [GO:0004132]; importin-alpha family protein binding [GO:0061676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] DLILLLATVASSVPNFK;QERIKEYEMLFLVSNEEMHK 2 7.2 0.10762 0.36376 10.1352 0 0 0 0 0 0 0 10.3911 0 0 0 Q9BWV7 TTLL2_HUMAN Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2) TTLL2 C6orf104 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] ciliary basal body [GO:0036064] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] GILIFSDFK;HTPHKTLMPYASLFQSHSCKTK 2 5.2 0.93376 -0.49988 10.0515 0 0 0 0 0 0 0 0 0 0 0 Q9BWW4 SSBP3_HUMAN Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) SSBP3 SSDP SSDP1 Homo sapiens (Human) head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; mesendoderm development [GO:0048382]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prechordal plate formation [GO:0021501]; protein-containing complex assembly [GO:0065003] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] DTCEHSSEAK;GSAVPSDGQAREK 2 5.9 0.96563 -1.1333 0 0 0 2.74522 0 0 0 0 0 0 0 0 Q9BWW7 SCRT1_HUMAN Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (hScrt) SCRT1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222] nuclear body [GO:0016604] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" QTHRSLDSQLARR;SLDSQLARR 2 3.7 0.96533 -1.215 12.7204 12.5276 0 0 0 0 0 0 0 0 8.24741 0 Q9BWX1 PHF7_HUMAN PHD finger protein 7 (Testis development protein NYD-SP6) PHF7 Homo sapiens (Human) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] GFHGFLPEDIKKEAAR 1 4.2 0.95897 -1.0344 0 0 0 9.77864 0 0 0 0 0 0 0 0 Q9BWX5 GATA5_HUMAN Transcription factor GATA-5 (GATA-binding factor 5) GATA5 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; cardiac muscle tissue development [GO:0048738]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitric oxide [GO:0071732]; endocardial cushion fusion [GO:0003274]; heart induction [GO:0003129]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cardiac endothelial to mesenchymal transition [GO:0062000]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" NSEGEPVCNACGLYMK 1 4 0.78358 0.025286 0 0 0 0 0 6.75556 0 0 0 0 7.65084 0 Q9BX10 GTPB2_HUMAN GTP-binding protein 2 GTPBP2 Homo sapiens (Human) translational elongation [GO:0006414] extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093] alpha-aminoacyl-tRNA binding [GO:1904678]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] EVDYDSDMPR;FLKHPEYLK;TVRQLER;VCSIQRNR 4 5.6 0.97494 -3.1376 0 0 0 0 9.39008 0 0 0 0 0 5.30199 11.8751 Q9BX10 GTPB2_HUMAN GTP-binding protein 2 GTPBP2 Homo sapiens (Human) translational elongation [GO:0006414] extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093] alpha-aminoacyl-tRNA binding [GO:1904678]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] FLKHPEYLK;LQEGRGEAIFTLSSVSGESLDLLK;VCSIQRNR;WRLQEGRGEAIFTLSSVSGESLDLLK 4 17.6 0.97168 -1.3483 0 0 0 0 7.44576 10.7789 0 0 0 10.3968 0 0 Q9BX26 SYCP2_HUMAN Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2) SYCP2 SCP2 Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; female meiotic nuclear division [GO:0007143]; fertilization [GO:0009566]; male genitalia morphogenesis [GO:0048808]; male meiotic nuclear division [GO:0007140]; meiotic recombination checkpoint signaling [GO:0051598]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; synaptonemal complex assembly [GO:0007130] "condensed chromosome, centromeric region [GO:0000779]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]" DNA binding [GO:0003677] EFVDFWEKIFQK;IFLNLVNGMLGDKRR;KLLTIILK;KLLTIILKNTVK;LCKIEDADHHIHK;LLTIILKNTVKISK;MVAWFEKSK;NITKKMDK;NSDKGNRNNSQLEK;QQKVFCAETEKELSK;SVLLNKTIEESLIYRK;TIEESLIYRK;TIEESLIYRKK;TIPEGRIRLPR 14 8.4 0.97853 -7.3433 5.08228 0 10.7902 0 5.67522 3.52544 12.5858 4.79805 11.3383 5.41248 13.0254 0 Q9BX40 LS14B_HUMAN Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) LSM14B C20orf40 FAM61B RAP55B Homo sapiens (Human) maternal mRNA clearance [GO:0141065]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; non-membrane-bounded organelle assembly [GO:0140694]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417] cytoplasmic ribonucleoprotein granule [GO:0036464]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EFKKRPILLLVFWT 1 5.9 0.58626 0.1796 0 0 0 0 0 0 0 0 0 0 11.9945 0 Q9BX59 TPSNR_HUMAN Tapasin-related protein (TAPASIN-R) (TAP-binding protein-like) (TAP-binding protein-related protein) (TAPBP-R) (Tapasin-like) TAPBPL Homo sapiens (Human) negative regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002590]; peptide antigen assembly with MHC class I protein complex [GO:0002502] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; MHC class I peptide loading complex [GO:0042824]; plasma membrane [GO:0005886] MHC class I protein complex binding [GO:0023024]; TAP complex binding [GO:0062061] LEEMEKEQVR;TALGVIFASSLFLLALMFLGLQRR 2 6.7 0.96475 -1.2301 0 0 0 0 0 0 0 0 10.0032 0 0 10.2198 Q9BX63 FANCJ_HUMAN Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) BRIP1 BACH1 FANCJ Homo sapiens (Human) cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to vitamin [GO:0071295]; chiasma assembly [GO:0051026]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; G-quadruplex DNA unwinding [GO:0044806]; homologous recombination [GO:0035825]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nucleotide-excision repair [GO:0006289]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286]; spermatogonial cell division [GO:0007284] BRCA1-B complex [GO:0070532]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; RNA helicase activity [GO:0003724]" DGALLVAVCRGK;EVDSAREVK;GLFMVLDYLFRQNSR;NSPLPSSIISRKEK;TIKEVDSAREVK 5 4.2 0.97303 -2.5811 0 0 0 0 9.79545 0 0 10.3756 11.2995 0 8.57187 7.01357 Q9BX66 SRBS1_HUMAN Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; positive regulation of D-glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; stress fiber assembly [GO:0043149] adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; zonula adherens [GO:0005915] actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159] FFSELEFGKPTNLDK;MSSECDGGSK;QVDENWYEGRIPGTSR;SATASPQQPQAQQR;SEMSYIDGEKVVK 5 8.4 0.95514 -0.83018 0 0 0 6.06011 0 0 0 0 7.41134 7.90316 5.72819 10.2064 Q9BX69 CARD6_HUMAN Caspase recruitment domain-containing protein 6 CARD6 Homo sapiens (Human) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] ASWVMGRPFGSEQRPK;CLFSTFPQSAAICGLRHEVLK;EDLLAGVENLEIR;HSQPKPFHSVPSQPK;VLDEDSKEDLLAGVENLEIR 5 6.9 0.91655 -0.43469 11.1047 0 0 0 0 8.96763 5.59377 0 12.1867 0 10.1932 0 Q9BX70 BTBD2_HUMAN BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) neurogenesis [GO:0022008] cytosol [GO:0005829]; P-body [GO:0000932] AAGGSGGR 1 1.5 0.74342 0.10231 0 0 0 10.6411 0 0 0 0 0 0 0 0 Q9BX74 TM2D1_HUMAN TM2 domain-containing protein 1 (Amyloid-beta-binding protein) (hBBP) TM2D1 BBP Homo sapiens (Human) apoptotic signaling pathway [GO:0097190] plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930] VAVALSLFLGWLGADR 1 7.7 0.78286 0.030192 0 11.6986 0 0 0 0 0 0 0 0 0 0 Q9BX79 STRA6_HUMAN Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) STRA6 PP14296 UNQ3126/PRO10282/PRO19578 Homo sapiens (Human) adrenal gland development [GO:0030325]; alveolar primary septum development [GO:0061143]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cognition [GO:0050890]; developmental growth [GO:0048589]; diaphragm development [GO:0060539]; digestive tract morphogenesis [GO:0048546]; ductus arteriosus closure [GO:0097070]; ear development [GO:0043583]; embryonic camera-type eye formation [GO:0060900]; embryonic digestive tract development [GO:0048566]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; feeding behavior [GO:0007631]; female genitalia development [GO:0030540]; head development [GO:0060322]; head morphogenesis [GO:0060323]; heart development [GO:0007507]; kidney development [GO:0001822]; learning [GO:0007612]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; neuromuscular process [GO:0050905]; nose morphogenesis [GO:0043585]; paramesonephric duct development [GO:0061205]; positive regulation of behavior [GO:0048520]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; retinol transport [GO:0034633]; smooth muscle tissue development [GO:0048745]; uterus morphogenesis [GO:0061038]; ventricular septum development [GO:0003281]; vitamin A import into cell [GO:0071939]; vocal learning [GO:0042297] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] GARPGASRGRAR 1 1.8 0.97623 -1.48 0 0 0 0 0 0 0 0 0 10.0904 0 0 Q9BX82 ZN471_HUMAN Zinc finger protein 471 (EZFIT-related protein 1) ZNF471 ERP1 KIAA1396 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSQTSNLTQHQR;CHTGKRPYECIECGKAFR 2 5 0.84927 -0.070464 0 0 9.21425 0 0 0 0 0 6.59395 0 0 0 Q9BX82 ZN471_HUMAN Zinc finger protein 471 (EZFIT-related protein 1) ZNF471 ERP1 KIAA1396 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NVEKPSSK;SLLIALIVGKPSVFT 2 9.3 0.53882 0.18509 11.4856 11.3145 11.1773 0 0 0 0 9.70831 0 0 12.5202 0 Q9BX84 TRPM6_HUMAN "Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) [Cleaved into: TRPM6 kinase, cleaved form]" TRPM6 CHAK2 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; magnesium ion transmembrane transport [GO:1903830]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion transmembrane transporter activity [GO:0015085]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion transmembrane transporter activity [GO:0015095]; metal ion binding [GO:0046872]; monoatomic cation channel activity [GO:0005261]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion transmembrane transporter activity [GO:0005385] ETGRNSPEDDMQL;GKESEQWSVEKHTTK;GVFDKRECSTIIPSSK;KNSWLKIIISIILPPTILTLEFK;VTEMYFQLK;WQTCLPSTCDSDSSR;YLSLQKIHCR;YQYYSMPSSLLR 8 5.6 0.98039 -1.6834 9.32609 8.35235 7.56955 0 0 0 8.40603 0 11.0957 0 0 9.00096 Q9BX95 SGPP1_HUMAN Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) SGPP1 SPP1 Homo sapiens (Human) ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392] NGLAAELGPASPRR 1 3.2 0.93192 -0.49083 0 0 0 0 0 0 0 0 0 0 10.2444 0 Q9BX97 PLVAP_HUMAN Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1) PLVAP FELS PV1 Homo sapiens (Human) developmental process [GO:0032502]; MAPK cascade [GO:0000165]; positive regulation of cellular extravasation [GO:0002693]; regulation of vascular permeability [GO:0043114]; tumor necrosis factor-mediated signaling pathway [GO:0033209] caveola [GO:0005901]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802] AGGSSRGCWYYLR;INASFRQCQGDR;LQAECSRQTQLALEEKAVLR;TLEVEIAK;VIYTNNQR 5 13.8 0.97203 -1.3563 0 0 0 0 11.3265 8.81903 0 0 11.5563 0 0 4.48504 Q9BXA7 TSSK1_HUMAN Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A) TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81 Homo sapiens (Human) protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DDAAVLK;GALHEDEAR;GALHEDEARK 3 4.6 0.96479 -1.2501 0 0 0 0 0 0 0 0 0 0 11.6307 0 Q9BXB1 LGR4_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888] NFPFLEELQLAGNDLSFIHPK 1 2.2 0.64797 0.17076 0 0 0 0 0 9.49215 0 0 0 0 0 0 Q9BXB4 OSB11_HUMAN Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) OSBPL11 ORP11 OSBP12 Homo sapiens (Human) fat cell differentiation [GO:0045444]; lipid transport [GO:0006869]; positive regulation of sequestering of triglyceride [GO:0010890] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654] sterol binding [GO:0032934] ATDAKERQHWVSR;ISLSNHYK;LWKNVTDSLRESEIDK;TETGTPWKTKYFIK 4 6.8 0.93663 -0.5471 0 0 0 0 8.749 0 0 0 0 0 6.79507 11.3561 Q9BXB5 OSB10_HUMAN Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) OSBPL10 ORP10 OSBP9 Homo sapiens (Human) phosphatidylserine acyl-chain remodeling [GO:0036150] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020] cholesterol binding [GO:0015485]; phosphatidylserine binding [GO:0001786]; phospholipid transporter activity [GO:0005548] EPALEGVLSKYTNLLQGWQNR 1 2.7 0.91842 -0.43643 0 0 0 0 0 0 0 0 0 0 7.82928 0 Q9BXB7 SPT16_HUMAN Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12) SPATA16 Homo sapiens (Human) spermatid development [GO:0007286]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; Golgi apparatus [GO:0005794] MRKPDLALNHAHR;TALELCSK 2 3.7 0.96387 -1.2057 0 0 0 0 10.3423 0 10.6176 10.8354 10.4673 0 0 0 Q9BXC9 BBS2_HUMAN BBSome complex member BBS2 (Bardet-Biedl syndrome 2 protein) BBS2 Homo sapiens (Human) adult behavior [GO:0030534]; artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; melanosome transport [GO:0032402]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; positive regulation of multicellular organism growth [GO:0040018]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sperm axoneme assembly [GO:0007288]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; stereocilium [GO:0032420] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] KQNLLLELRNYEENAK;LLPVFTLKLRHK;MLLPVFTLK 3 4 0.91293 -0.32232 0 0 0 0 0 0 0 0 10.1739 0 9.97656 0 Q9BXD5 NPL_HUMAN N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) NPL C1orf13 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] cytosol [GO:0005829] identical protein binding [GO:0042802]; N-acetylneuraminate lyase activity [GO:0008747] SLDFLSFTDLK 1 3.4 0.78529 0.018117 0 0 0 0 0 0 0 0 0 0 0 8.24978 Q9BXF3 CECR2_HUMAN Chromatin remodeling regulator CECR2 (Cat eye syndrome critical region protein 2) CECR2 KIAA1740 Homo sapiens (Human) apoptotic DNA fragmentation [GO:0006309]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; cytoskeleton organization [GO:0007010]; cytoskeleton-dependent cytokinesis [GO:0061640]; execution phase of apoptosis [GO:0097194]; inner ear receptor cell stereocilium organization [GO:0060122]; neural fold formation [GO:0001842]; neural tube closure [GO:0001843]; single fertilization [GO:0007338]; vesicle-mediated transport [GO:0016192] CERF complex [GO:0090537]; euchromatin [GO:0000791]; nucleus [GO:0005634] ATP-dependent chromatin remodeler activity [GO:0140658] EFLDLDNHNAATK;LLSEDFLPEICNMIAQK;QPFTMQPPVGINSLRGPR;QVTESFRER 4 3.8 0.9625 -1.1029 0 0 0 0 0 8.87295 0 0 0 0 9.25108 10.8304 Q9BXF6 RFIP5_HUMAN Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) RAB11FIP5 GAF1 KIAA0857 RIP11 Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of adiponectin secretion [GO:0070164]; regulated exocytosis [GO:0045055]; regulation of protein localization to cell surface [GO:2000008] centriolar satellite [GO:0034451]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; transport vesicle membrane [GO:0030658] gamma-tubulin binding [GO:0043015]; small GTPase binding [GO:0031267] TYSDEANQMR 1 1.5 0.94004 -0.58172 0 0 0 0 0 0 0 0 0 0 9.87977 0 Q9BXF9 TEKT3_HUMAN Tektin-3 TEKT3 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; regulation of brood size [GO:0060378] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; outer acrosomal membrane [GO:0002081]; sperm flagellum [GO:0036126] DLSDKQTAYRIDDK;FTDDNILRSQSER;IAETADAK;IDDKCHHLR 4 8.2 0.9759 -2.3285 0 0 0 0 0 0 0 0 10.8894 6.00288 0 0 Q9BXG8 SPZ1_HUMAN Spermatogenic leucine zipper protein 1 (Testis-specific protein 1) (Testis-specific protein NYD-TSP1) SPZ1 TSP1 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] SLDVCLNK 1 1.9 0.91585 -0.34779 0 0 0 0 0 0 0 0 11.7608 0 0 0 Q9BXI6 TB10A_HUMAN TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) TBC1D10A EPI64 TBC1D10 Homo sapiens (Human) "activation of cysteine-type endopeptidase activity [GO:0097202]; positive regulation of proteolysis [GO:0045862]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165] IIFRVGLVLLK;VGLVLLK;WLDMLNNWDKWMAKK 3 5.1 0.68501 0.16305 0 0 0 0 0 6.52991 0 0 0 5.55185 0 7.62775 Q9BXI9 C1QT6_HUMAN Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) collagen trimer [GO:0005581]; extracellular space [GO:0005615] identical protein binding [GO:0042802] GIYFFSLNVHSWNYK;SVGTSLEQAQMSTLTCPLFIPTVGR 2 26 0.60375 0.17802 0 0 0 0 0 0 12.5306 0 7.56331 0 0 0 Q9BXJ1 C1QT1_HUMAN Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) C1QTNF1 CTRP1 UNQ310/PRO353 Homo sapiens (Human) negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906] collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; identical protein binding [GO:0042802] GDRGDRGLQGK 1 3.9 0.76935 0.057561 0 0 0 0 0 0 0 0 0 9.42666 0 0 Q9BXJ3 C1QT4_HUMAN Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4) C1QTNF4 CTRP4 Homo sapiens (Human) positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760] extracellular space [GO:0005615] cytokine activity [GO:0005125] RREMQSQSVMLALR;SAFSAAR;TLSVKLMK 3 10.9 0.90194 -0.2617 0 0 0 0 0 7.31424 0 0 0 10.236 0 0 Q9BXJ4 C1QT3_HUMAN Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819] collagen trimer [GO:0005581]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020] identical protein binding [GO:0042802] IVQSHQQTGR 1 3.1 0.79602 0.015423 0 0 0 8.89818 0 0 0 0 0 0 0 0 Q9BXJ7 AMNLS_HUMAN Protein amnionless [Cleaved into: Soluble protein amnionless] AMN UNQ513/PRO1028 Homo sapiens (Human) cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898]; renal protein absorption [GO:0097017] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cargo receptor activity [GO:0038024]; signaling receptor binding [GO:0005102] VGLGPGASPVR 1 2.4 0.9409 -0.58311 0 11.255 0 0 0 0 0 0 0 0 0 0 Q9BXJ8 TACAN_HUMAN Transmembrane protein 120A (Protein TACAN) (Transmembrane protein induced by tumor necrosis factor alpha) TMEM120A TACAN TMPIT Homo sapiens (Human) antiviral innate immune response [GO:0140374]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; fat cell differentiation [GO:0045444]; monoatomic ion transmembrane transport [GO:0034220]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886] coenzyme A binding [GO:0120225]; monoatomic ion channel activity [GO:0005216] LYLTIILILISFTCRFLLNSR 1 6.1 0.8264 -0.021489 0 0 0 0 0 0 0 9.00228 0 0 0 0 Q9BXJ9 NAA15_HUMAN "N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)" NAA15 GA19 NARG1 NATH TBDN100 Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NatA complex [GO:0031415]; nuclear body [GO:0016604]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] acetyltransferase activator activity [GO:0010698]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] EELIPEKLAKVETPLEEAIK;ILEEFRKTQQTSPDK;LEDAADVYR;TVLKQEMNR;YDEAIKCYRNALK;YPRGLVPR 6 8.5 0.97342 -2.9746 0 13.5477 12.0318 0 0 7.30214 0 0 0 0 0 10.6624 Q9BXK5 B2L13_HUMAN Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) BCL2L13 MIL1 CD003 Homo sapiens (Human) apoptotic process [GO:0006915]; canonical glycolysis [GO:0061621]; fat cell differentiation [GO:0045444]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oxidative phosphorylation [GO:0006119]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; regulation of apoptotic process [GO:0042981] membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656] ILVPLVLLRQMLLELTRR;SLDSNGAGEK 2 5.8 0.91414 -0.33558 0 0 0 0 0 3.86404 0 0 0 0 0 0 Q9BXL5 HEMGN_HUMAN Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) HEMGN EDAG NDR PRO1037 PRO1620 Homo sapiens (Human) cell differentiation [GO:0030154]; regulation of osteoblast differentiation [GO:0045667] nucleoplasm [GO:0005654] ALAPIEK 1 1.4 0.93373 -0.51025 0 0 0 11.6586 0 0 0 0 0 9.20853 0 0 Q9BXL6 CAR14_HUMAN Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) CARD14 CARMA2 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; regulation of immune response [GO:0050776]; tumor necrosis factor-mediated signaling pathway [GO:0033209] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] CARD domain binding [GO:0050700] AGHLLDLLK;CICPSRLTPYLRQAK;CRSLQEELYLLKQELQR;SLTFSLAEKDILEQSLDEAR;VATSGDSFYIR 5 7.2 0.98018 -1.5616 0 0 0 9.60112 7.47151 8.75992 0 0 10.8943 7.46508 0 9.1485 Q9BXL6 CAR14_HUMAN Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) CARD14 CARMA2 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; regulation of immune response [GO:0050776]; tumor necrosis factor-mediated signaling pathway [GO:0033209] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] CARD domain binding [GO:0050700] RCRSTLGWASALSWADVK;SLTFSLAEKDILEQSLDEAR 2 8.8 0.86195 -0.0828 0 0 0 0 0 0 0 0 0 0 0 8.24555 Q9BXL7 CAR11_HUMAN Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) CARD11 CARMA1 Homo sapiens (Human) "B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; homeostasis of number of cells [GO:0048872]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of T cell differentiation [GO:0045580]; T cell costimulation [GO:0031295]; thymic T cell selection [GO:0045061]; TORC1 signaling [GO:0038202]" CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] CARD domain binding [GO:0050700]; guanylate kinase activity [GO:0004385] DQAFHSRDEAQTQYSQCLIEK;EEAHWTIQR;IEMVRREACIVNLESK;IGEEQRK;LTPYLRQCK;SSLDATK;YAQLSEEK 7 6.7 0.97511 -3.9804 0 0 0 10.352 7.2033 6.11168 6.38319 0 10.1483 8.76487 0 0 Q9BXM0 PRAX_HUMAN Periaxin PRX KIAA1620 Homo sapiens (Human) axon ensheathment [GO:0008366]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of RNA splicing [GO:0043484] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] AKEVAEAKVAK;APEVKLPK;ARVGGEGAEEQPPGAER;EARSRSAEELR;EGIFVRELREDSPAAR;LEMIETKVKPSSK;LKVSKFAISLPK;LPEMQVPK 8 6.6 0.97611 -4.4608 0 0 0 0 7.83807 9.34005 9.68226 11.9676 0 0 0 0 Q9BXM7 PINK1_HUMAN "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" PINK1 Homo sapiens (Human) "activation of protein kinase B activity [GO:0032148]; autophagy of mitochondrion [GO:0000422]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine secretion [GO:0014046]; establishment of protein localization to mitochondrion [GO:0072655]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type 2 mitophagy [GO:1905091]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of oxidative phosphorylation [GO:0002082]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle transport [GO:1902803]; respiratory electron transport chain [GO:0022904]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; TORC2 signaling [GO:0038203]; ubiquitin-dependent protein catabolic process [GO:0006511]" astrocyte projection [GO:0097449]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; Lewy body [GO:0097413]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; C3HC4-type RING finger domain binding [GO:0055131]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein kinase B binding [GO:0043422]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; TORC2 complex binding [GO:1904841]; ubiquitin protein ligase binding [GO:0031625] GERPGWAAGPGAEPR;GLQLGRALLLRFTGKPGR;LTEKCCVETK 3 7.4 0.96527 -1.1586 0 0 13.4255 0 0 0 9.5372 11.1234 0 11.634 0 10.1011 Q9BXM9 FSD1L_HUMAN FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein) FSD1L CCDC10 CSDUFD1 FSD1CL FSD1NL Homo sapiens (Human) EPEEFSKVHKNCINTLNK;ESMINCIKQEQAR 2 21.4 0.94427 -0.63816 0 0 0 0 0 0 0 0 0 8.89367 0 0 Q9BXN1 ASPN_HUMAN Asporin (Periodontal ligament-associated protein 1) (PLAP-1) ASPN PLAP1 SLRR1C UNQ215/PRO241 Homo sapiens (Human) bone mineralization [GO:0030282]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; response to fluoride [GO:1902617] cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] LGLGNNK;VGVNDFCPTVPKMKK 2 5.8 0.97819 -1.9549 0 0 8.29421 10.2909 0 0 9.27482 0 0 0 0 11.0393 Q9BXN2 CLC7A_HUMAN C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369) CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082 Homo sapiens (Human) "antifungal innate immune response [GO:0061760]; apoptotic signaling pathway [GO:0097190]; carbohydrate mediated signaling [GO:0009756]; cell activation [GO:0001775]; cell recognition [GO:0008037]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to molecule of fungal origin [GO:0071226]; defense response to protozoan [GO:0042832]; detection of fungus [GO:0016046]; detection of molecule of fungal origin [GO:0032491]; detection of yeast [GO:0001879]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell maturation [GO:1903431]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lymphocyte activation [GO:0051251]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of respiratory burst [GO:0060267]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] (1->3)-beta-D-glucan binding [GO:0001872]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; MHC protein binding [GO:0042287]; pattern recognition receptor activity [GO:0038187] RQCWQLGSNLLK 1 4.9 0.6688 0.16875 0 0 0 0 0 0 0 0 0 7.98988 0 0 Q9BXP2 S12A9_HUMAN Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) SLC12A9 CCC6 CIP1 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] chloride:monoatomic cation symporter activity [GO:0015377]; potassium:chloride symporter activity [GO:0015379] NVVLARASGALPPERLSR;YLLRLDVRK 2 3 0.97215 -2.7158 0 0 0 0 0 0 0 0 0 13.0717 0 0 Q9BXP5 SRRT_HUMAN Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) SRRT ARS2 ASR2 Homo sapiens (Human) mRNA processing [GO:0006397]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of neurogenesis [GO:0050769]; primary miRNA processing [GO:0031053]; regulation of DNA-templated transcription [GO:0006355]; response to arsenic-containing substance [GO:0046685] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] DPEQEVEK;DPEQEVEKFVTSNTQELGK;DPEQEVEKFVTSNTQELGKDK;EGNPAEINVER;ESLSEEEAQK;EVAFFNNFLTDAK;FVTSNTQELGK;GDDWNDREWDR;GDSDDEYDR;GEYRDYDR;HAEKIEEVK;ISHGEVLEWQKTFEEK;KSEGDGDKEEK;MGDSDDEYDRRR;TKKSEGDGDK;VALSEPQPER;YPGFMRVALSEPQPER 17 16 0.97837 -6.5862 0 8.30638 11.3849 8.96815 11.4831 5.35498 10.1481 3.7967 0 9.68259 6.03773 0 Q9BXP8 PAPP2_HUMAN Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E) PAPPA2 PLAC3 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cell surface receptor signaling pathway [GO:0007166]; proteolysis [GO:0006508]; regulation of cell growth [GO:0001558]; response to salt stress [GO:0009651] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] KSPPEESNQNGGEGSYR;KTSIVDCGIYTPKGYLDQWATR 2 2.2 0.97655 -1.4897 0 0 0 0 11.9154 0 0 0 12.6899 3.8166 0 11.4423 Q9BXR0 TGT_HUMAN Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) QTRT1 TGT TGUT Homo sapiens (Human) tRNA modification [GO:0006400]; tRNA-guanine transglycosylation [GO:0101030] cytoplasmic side of mitochondrial outer membrane [GO:0032473]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; transferase complex [GO:1990234]; tRNA-guanine transglycosylase complex [GO:0120507] metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] ATCLEEMTK;LVAECSRSR;VEEAMYRSIR 3 6.9 0.97206 -2.7906 0 0 0 0 0 0 0 9.73774 0 0 0 1.94328 Q9BXR5 TLR10_HUMAN Toll-like receptor 10 (CD antigen CD290) TLR10 UNQ315/PRO358 Homo sapiens (Human) cellular response to bacterial lipopeptide [GO:0071221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]" ELRYLDLSNNRLK;LSDSVFRCLPK;NLSLENAKTSVLLLNK;NPFRCTCELK;VLILCHNR 5 7.2 0.97399 -2.4263 0 9.21111 0 0 0 8.9755 0 0 0 0 0 9.82437 Q9BXR6 FHR5_HUMAN Complement factor H-related protein 5 (FHR-5) CFHR5 CFHL5 FHR5 Homo sapiens (Human) "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982] DGRWQSLPR;GECHVPILEANVDAQPKK;YRCSDIFRYR 3 6.5 0.98027 -1.8042 11.1295 0 0 0 0 0 0 0 0 6.84336 0 0 Q9BXS0 COPA1_HUMAN Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] COL25A1 Homo sapiens (Human) collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] GERGEPGAPGPK;GRRGESGPPGPPGPK;ITTLTVTGPPGPPGPQGLQGPK;LIKGDQGQAGPPGPPGPPGPR 4 12 0.97585 -2.3056 0 0 0 9.91067 8.85175 0 9.78013 12.7087 0 0 0 0 Q9BXS1 IDI2_HUMAN Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2) IDI2 Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isopentenyl diphosphate metabolic process [GO:0046490]; isoprenoid biosynthetic process [GO:0008299] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777] isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; metal ion binding [GO:0046872] SDRIWGEHEICYLLLVRK 1 7.9 0.86286 -0.082922 0 0 0 0 0 0 0 9.84229 0 0 0 0 Q9BXS5 AP1M1_HUMAN AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) AP1M1 CLTNM Homo sapiens (Human) endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615] MRVFLSGMPELR 1 2.8 0.95315 -0.67639 0 11.9043 0 0 0 0 0 0 0 0 0 0 Q9BXT2 CCG6_HUMAN Voltage-dependent calcium channel gamma-6 subunit (Neuronal voltage-gated calcium channel gamma-6 subunit) CACNG6 Homo sapiens (Human) calcium ion transport [GO:0006816]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514] L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] calcium channel regulator activity [GO:0005246]; voltage-gated calcium channel activity [GO:0005245] GAAGRRR;GAEFLLR 2 5.4 0.89522 -0.24398 11.7215 11.3982 0 0 0 8.17258 11.1988 11.0513 0 0 8.84624 0 Q9BXT4 TDRD1_HUMAN Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; pi-body [GO:0071546]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] metal ion binding [GO:0046872] LAELQASLSK;LPNGFKAEIGQPCCAFFADIQSR;SLAEHCQQKLPNGFK 3 3.9 0.95148 -0.71578 0 0 0 0 10.1869 0 8.05604 0 0 9.73307 0 0 Q9BXT5 TEX15_HUMAN Testis-expressed protein 15 (Cancer/testis antigen 42) (CT42) TEX15 Homo sapiens (Human) cell differentiation [GO:0030154]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; male meiotic nuclear division [GO:0007140]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transposable element silencing [GO:0010526] cytoplasm [GO:0005737]; nucleus [GO:0005634] DQNIPHK;DQNIPHKDLR;DTEDRITWK;DTEDRITWKVK;ENQIDTAFLSSTSK;EVESRISK;KQDSHTNENFSNIDEKEDK;LDKAVVHLK;MKNFADLEDSSKHEEK;SSTSTIK 10 3.4 0.97828 -6.9031 0 0 6.26508 0 6.45108 9.03733 10.3184 13.28 10.9767 7.53978 8.89542 0 Q9BXT6 M10L1_HUMAN RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) germ cell development [GO:0007281]; male meiosis I [GO:0007141]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GISPGDCTCK;LVKNYRSHEALLMLPSR;MLSLAAKLVAFFWR;NGDLLVLEVPGLAEGRPSLYAGDK;NKGDIEVTQVTHFGTLKEGR;RDAAPVHEATHFYGTILLKNK;SHEALLMLPSRLFYHR;SKTMVIWIENK;TFIVVICDGKNPGR 9 11.1 0.97495 -3.1498 9.57996 7.71445 0 9.43582 8.80903 0 0 0 9.80481 9.53345 6.92255 0 Q9BXT6 M10L1_HUMAN RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) germ cell development [GO:0007281]; male meiosis I [GO:0007141]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ALLIVLGNPHVLVRLWR;GISPGDCTCK;LVKNYRSHEALLMLPSR;NGDLLVLEVPGLAEGRPSLYAGDK;NKGDIEVTQVTHFGTLKEGR;RDAAPVHEATHFYGTILLKNK;SHEALLMLPSRLFYHR;SKTMVIWIENK;TFIVVICDGKNPGR 9 11.8 0.89233 -0.21273 0 0 0 10.3349 0 0 0 0 0 0 0 0 Q9BXT8 RNF17_HUMAN RING finger protein 17 (Tudor domain-containing protein 4) RNF17 TDRD4 Homo sapiens (Human) spermatid development [GO:0007286] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] AQDKFMTCSVIK;DIQPLAQPCSLK;IFVSSIK;MAAEASKTGPSRSSYQR;NTRKPCSPTR;QFDQLLAFFDSRK;VEALPPLTDFR;YCTSEHTEEMLKEKPR 8 6 0.9798 -1.8568 0 0 0 0 0 7.47476 0 0 9.92779 11.0927 0 12.1996 Q9BXU1 STK31_HUMAN Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396) STK31 SGK396 Homo sapiens (Human) acrosomal vesicle [GO:0001669] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SLLCSLICYR;TCEYVSEGNILIAQR;TYIDTRMK;VEDVVGSHIEDAVTFWAQSINR 4 5.4 0.98072 -1.6234 12.3046 0 9.2175 7.40489 11.6121 0 7.92878 0 0 0 0 0 Q9BXU3 TX13A_HUMAN Testis-expressed protein 13A TEX13A Homo sapiens (Human) metal ion binding [GO:0046872]; mRNA binding [GO:0003729] AASMETTEKLER 1 2.9 0.88884 -0.18757 0 0 10.4465 0 0 0 0 0 0 0 0 0 Q9BXU7 UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) USP26 Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380] DRLVLYFKSGK;EINKTSFHKVDEK;EMLLLNLK;LSDNIQNVVLKSYR;LTLTCGELSENQHKK;LVLYFKSGK;NLLRPTKLNLQKSNR;QLKLKELEENK 8 9.5 0.97883 -2.0538 0 0 11.5037 0 8.1282 0 15.0375 10.217 0 7.98743 8.17672 0 Q9BXW4 MLP3C_HUMAN Microtubule-associated protein 1 light chain 3 gamma (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (Microtubule-associated proteins 1A/1B light chain 3C) (MAP1A/MAP1B LC3 C) (MAP1A/MAP1B light chain 3 C) MAP1LC3C Homo sapiens (Human) aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; protein exit from endoplasmic reticulum [GO:0032527] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule [GO:0005874]; organelle membrane [GO:0031090] phosphatidylethanolamine binding [GO:0008429]; ubiquitin protein ligase binding [GO:0031625] IPSVRPFK 1 5.4 0.93666 -0.54942 0 0 14.1141 0 12.205 0 0 0 0 12.5854 12.6519 0 Q9BXW6 OSBL1_HUMAN Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) OSBPL1A ORP1 OSBP8 OSBPL1 OSBPL1B Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol transfer activity [GO:0120015] FFGWRLFWVVLEHGVLSWYR;LDREISNFLKMIK;LEQEQEK;LRPDIRAMENGEIDQASEEKK;NTEAEQQLLHHAR;QVVQDLLK 6 8.6 0.9787 -1.9203 0 0 8.07959 0 0 10.5294 7.2077 9.05145 0 0 9.73667 0 Q9BXW7 HDHD5_HUMAN Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5) HDHD5 CECR5 Homo sapiens (Human) glycerophospholipid biosynthetic process [GO:0046474] mitochondrion [GO:0005739] LVNSQGQLR 1 2.1 0.92065 -0.4437 0 0 0 0 9.93472 0 0 0 0 0 0 0 Q9BXW9 FACD2_HUMAN Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; double-strand break repair involved in meiotic recombination [GO:1990918]; gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; interstrand cross-link repair [GO:0036297]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; neuronal stem cell population maintenance [GO:0097150]; regulation of CD40 signaling pathway [GO:2000348]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]; response to gamma radiation [GO:0010332] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA polymerase binding [GO:0070182] ATEDGEEDEVSAGEK;DLQGEEIK;EQDSDESYDDSD;HTFVVFFRVMMAELEK;LLLGIDILQPAIIKTLFEKLPEYFFENK;QLSSTVFKYK;SLIKLLLGIDILQPAIIKTLFEK 7 6.4 0.98063 -1.637 14.0036 6.17121 0 7.04614 5.494 8.3872 9.12964 5.98274 7.24926 0 9.65338 6.25452 Q9BXX0 EMIL2_HUMAN EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) cell adhesion mediated by integrin [GO:0033627]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular region [GO:0005576] extracellular matrix constituent conferring elasticity [GO:0030023] TRAPGLSSQHPKPDTTVSGDTETGQSPGVFNTK;VAEATRMLNGR 2 4.2 0.94278 -0.62257 0 0 0 0 0 0 8.75512 10.7004 0 11.3898 0 0 Q9BXX2 AN30B_HUMAN Ankyrin repeat domain-containing protein 30B (Serologically defined breast cancer antigen NY-BR-1.1) ANKRD30B Homo sapiens (Human) ATSGKFEQSTEETPR;IDQYEKEK;IEDQMFPSESKR;LLAAAGK;NEQTLRAAQMFPSESKQK;VTINIQFPEMK 6 5.1 0.97481 -2.3647 0 0 0 12.0041 0 6.36454 0 12.4745 12.9134 0 0 9.39038 Q9BXX3 AN30A_HUMAN Ankyrin repeat domain-containing protein 30A (Serologically defined breast cancer antigen NY-BR-1) ANKRD30A Homo sapiens (Human) DGLLKATCGMK;DHCEQRTGK;EAEHMYQNEQDNVNK;EIMSPAK;ELQKDHCEQRTGK;HQYQEKENK;ITIDIHFLERK;LEESPDNDGFLKAPCRMK;LEGSPVK;NRIYQYEK;QEEDEEYSCDSR;SLFESSAKIQVCIPESIYQKVMEINR 12 9.8 0.97299 -2.6193 12.6073 13.8104 4.87081 0 10.3929 9.05072 10.1033 10.3213 8.35922 5.67005 3.90997 12.6422 Q9BXY0 MAK16_HUMAN Protein MAK16 homolog (NNP78) (Protein RBM13) MAK16 RBM13 Homo sapiens (Human) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] EEKGQCYLYMK;ITQYLIRIR 2 6.7 0.95194 -0.71298 7.66128 0 0 0 0 0 9.6241 0 0 0 0 0 Q9BXY4 RSPO3_HUMAN R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) RSPO3 PWTSR THSD2 Homo sapiens (Human) "blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; sprouting angiogenesis [GO:0002040]" extracellular region [GO:0005576]; extracellular space [GO:0005615] frizzled binding [GO:0005109]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102] TQPTPCRR 1 2.7 0.84015 -0.043952 0 0 0 0 0 0 0 0 0 5.78999 0 0 Q9BXY5 CAYP2_HUMAN Calcyphosin-2 (Calcyphosine-2) CAPS2 UG0636c06 Homo sapiens (Human) calcium ion binding [GO:0005509] GVAATSR;VDYGEFKR 2 2.8 0.65935 0.16917 0 0 0 0 8.6632 0 10.0462 0 0 0 0 0 Q9BXY5 CAYP2_HUMAN Calcyphosin-2 (Calcyphosine-2) CAPS2 UG0636c06 Homo sapiens (Human) calcium ion binding [GO:0005509] MIDHLSR;VDYGEFKR 2 3.9 0.91783 -0.35925 6.32171 0 0 3.58207 0 0 9.3624 9.50345 0 0 0 0 Q9BXY8 BEX2_HUMAN Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2) BEX2 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of protein ubiquitination [GO:0031397]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; signaling receptor binding [GO:0005102] ALNNLIVENVNQENDEK;IGEEVRQLMEKLR;LGEPQARMR;MQKMVVCGAK 4 30.6 0.9727 -2.9549 0 0 12.9773 0 13.6488 0 0 9.318 0 0 13.7465 11.7654 Q9BY07 S4A5_HUMAN Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5) SLC4A5 NBC4 Homo sapiens (Human) bicarbonate transport [GO:0015701]; cerebrospinal fluid secretion [GO:0033326]; epithelial cell development [GO:0002064]; mitochondrion distribution [GO:0048311]; regulation of gene expression [GO:0010468]; regulation of intracellular pH [GO:0051453]; regulation of systemic arterial blood pressure [GO:0003073]; renal system process [GO:0003014]; retina development in camera-type eye [GO:0060041]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] FSRYFPTKPTRPDRGWFVAPFGK;LFLMPAK;LLGNSCK;SMNDISLTPNTDQRK;VTGIIVFILTGISVFLAPILK 5 7.5 0.95271 -0.76937 8.98248 0 9.87696 9.77673 0 9.83254 0 0 0 4.5145 0 0 Q9BY11 PACN1_HUMAN Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) PACSIN1 KIAA1379 Homo sapiens (Human) actin filament organization [GO:0007015]; cytoskeleton organization [GO:0007010]; negative regulation of endocytosis [GO:0045806]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488] axon terminus [GO:0043679]; COPI-coated vesicle [GO:0030137]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone [GO:0098833]; ruffle membrane [GO:0032587]; synapse [GO:0045202] cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] EMNSKTEQSVTPEQQKK;IEKAYGQQLTDWAK;LAMTREMNSK;MKELEAAK;YEKVLEDVGK 5 12.2 0.97594 -4.5102 0 0 11.1055 0 0 12.9239 0 0 11.1476 0 0 0 Q9BY12 SCAPE_HUMAN S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) antral ovarian follicle growth [GO:0001547]; retina development in camera-type eye [GO:0060041]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; ooplasm [GO:1990917]; sperm head [GO:0061827] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EYEQRLNELQEER;VSLATEATR 2 1.6 0.9548 -0.95151 0 0 0 3.28428 0 0 0 0 0 0 8.10638 9.54369 Q9BY15 AGRE3_HUMAN Adhesion G protein-coupled receptor E3 (EGF-like module receptor 3) (EGF-like module-containing mucin-like hormone receptor-like 3) ADGRE3 EMR3 UNQ683/PRO1562 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] NVSLSKSVTLTFQHVK;TEGRQEISSTATTILRDVESK;TKTSCAK;VFCVYWK;VLETALKDPEQK 5 9.7 0.97315 -2.5079 0 0 0 0 8.66359 0 0 11.1864 13.3437 0 0 0 Q9BY21 GPR87_HUMAN G-protein coupled receptor 87 (G-protein coupled receptor 95) GPR87 GPR95 FKSG78 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028] IVHDAGFGPWYFKFILCR 1 5 0.91972 -0.4378 0 0 0 0 0 0 0 10.0044 0 0 0 0 Q9BY31 ZN717_HUMAN Zinc finger protein 717 (Krueppel-like factor X17) ZNF717 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNECRKTFSQK;TVLTIHQR 2 2.1 0.9285 -0.4826 12.5188 7.40965 0 12.4119 10.4635 0 11.1492 0 11.4076 0 0 0 Q9BY41 HDAC8_HUMAN Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-) HDAC8 HDACL1 CDA07 Homo sapiens (Human) chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204] cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein lysine deacetylase activity [GO:0033558]; tubulin deacetylase activity [GO:0042903]" ETCVYVALYKAF 1 7.6 0.88727 -0.18535 6.36459 0 7.05561 5.84674 0 6.3638 0 0 0 0 0 0 Q9BY43 CHM4A_HUMAN Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) CHMP4A C14orf123 SHAX2 CDA04 HSPC134 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; plasma membrane tubulation [GO:0097320]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] AYQDMDIDK;QLAEWVS 2 7.2 0.96457 -1.1526 0 0 0 0 0 0 0 0 0 0 11.4266 0 Q9BY44 EIF2A_HUMAN "Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]" EIF2A CDA02 MSTP004 MSTP089 Homo sapiens (Human) positive regulation of signal transduction [GO:0009967]; regulation of translation [GO:0006417]; response to amino acid starvation [GO:1990928]; ribosome assembly [GO:0042255]; SREBP signaling pathway [GO:0032933]; translational initiation [GO:0006413] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular space [GO:0005615] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] NQLEKIQKETALLQELEDLELGI 1 3.9 0.97508 -1.4573 0 0 10.9073 0 0 0 0 0 0 0 0 0 Q9BY64 UDB28_HUMAN UDP-glucuronosyltransferase 2B28 (UDPGT 2B28) (UGT2B28) (EC 2.4.1.17) UGT2B28 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471] glucuronosyltransferase activity [GO:0015020] FCLFCFWKFARK;LSDQMTFMERVK;TVINDPSYK 3 6.2 0.95509 -0.97004 0 0 11.8531 0 0 0 0 7.94959 0 11.1208 0 0 Q9BY66 KDM5D_HUMAN Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) KDM5D HY HYA JARID1D KIAA0234 SMCY Homo sapiens (Human) chromatin remodeling [GO:0006338]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; T cell antigen processing and presentation [GO:0002457] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681] EALATLPSSPGLLR;FPNSELLQR;GVTEAER;IVIEEGGYEAICKDR;LNYLDQIAK;NIGSLLRSHYER;SRRPRLETILALLVALQR 7 5.5 0.98189 -1.5843 9.43219 0 0 7.46671 10.6763 9.90126 0 0 0 0 0 0 Q9BY67 CADM1_HUMAN Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune system process [GO:0002376]; liver development [GO:0001889]; negative regulation of ERBB4 signaling pathway [GO:0120154]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; spermatogenesis [GO:0007283]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] cell adhesion molecule binding [GO:0050839]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] LRLLLLLFSAAALIPTGDGQNLFTK 1 5.7 0.83866 -0.039211 0 0 0 0 0 0 0 0 0 8.3486 0 0 Q9BY71 LRRC3_HUMAN Leucine-rich repeat-containing protein 3 LRRC3 C21orf102 LRRC3A UNQ9233/PRO31982 Homo sapiens (Human) plasma membrane [GO:0005886] DPIGPGP 1 2.7 0.7028 0.16054 0 0 11.3904 0 0 0 0 10.2447 0 0 11.1909 0 Q9BY76 ANGL4_HUMAN Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain] ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197 Homo sapiens (Human) angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; endothelial cell apoptotic process [GO:0072577]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipoprotein lipase activity [GO:0051005]; positive regulation of angiogenesis [GO:0045766]; protein unfolding [GO:0043335]; response to hypoxia [GO:0001666]; triglyceride homeostasis [GO:0070328] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802] IQQLFHK;IQQLFHKVAQQQRHLEK 2 4.2 0.87993 -0.14513 0 0 0 0 0 8.45562 0 0 0 0 7.63873 0 Q9BY77 PDIP3_HUMAN Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) POLDIP3 KIAA1649 PDIP46 Homo sapiens (Human) poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723] ALTNMSRTLVNKEEPPK;FDARQKIGLSDAR;GAAAKGR;VGIQQGLLSQSTR 4 11.9 0.98017 -1.8173 0 12.1837 0 0 0 0 0 10.6354 10.3945 0 0 10.2495 Q9BY89 K1671_HUMAN Uncharacterized protein KIAA1671 KIAA1671 Homo sapiens (Human) ATNGPSDSQAR;DQTSPAVKQGSPVEPK;EESDEEETASK 3 2.1 0.96315 -1.0992 0 0 0 0 0 0 0 0 0 5.43676 4.57555 0 Q9BYB0 SHAN3_HUMAN SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) SHANK3 KIAA1650 PROSAP2 PSAP2 Homo sapiens (Human) "adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; neuromuscular process controlling balance [GO:0050885]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]" ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; ionotropic glutamate receptor binding [GO:0035255]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; synaptic receptor adaptor activity [GO:0030160]; zinc ion binding [GO:0008270] EERKSPEDK 1 0.5 0.82547 -0.021224 0 0 0 0 0 0 0 0 0 0 7.55505 0 Q9BYB4 GNB1L_HUMAN Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF) GNB1L GY2 KIAA1645 WDR14 FKSG1 Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974] cytoplasm [GO:0005737]; nucleus [GO:0005634] ILATAGWDHRIR 1 3.7 0.92406 -0.4496 0 0 0 0 0 7.95902 0 0 0 0 0 0 Q9BYC5 FUT8_HUMAN "Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)" FUT8 Homo sapiens (Human) fibroblast migration [GO:0010761]; GDP-L-fucose metabolic process [GO:0046368]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; N-glycan processing [GO:0006491]; oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; receptor metabolic process [GO:0043112]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of gene expression [GO:0010468]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral protein processing [GO:0019082] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] alpha-(1->6)-fucosyltransferase activity [GO:0046921]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]; SH3 domain binding [GO:0017124] ITYLQNPKDCSK;LERLKQQNEDLR;YLIRPQPWLEKEIEEATK;YPTYPEAEK 4 8.9 0.96309 -1.1011 10.6393 11.0841 0 0 0 10.2488 0 0 0 0 0 8.89893 Q9BYC9 RM20_HUMAN "Large ribosomal subunit protein bL20m (39S ribosomal protein L20, mitochondrial) (L20mt) (MRP-L20)" MRPL20 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] HEGFAAALGDGKEPEGIFSR;ITAASQEHGLK;VTDRYFRIQEVLK 3 29.5 0.926 -0.45301 4.48633 0 0 13.3066 9.08183 0 0 0 0 0 0 0 Q9BYD1 RM13_HUMAN "Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13)" MRPL13 Homo sapiens (Human) mitochondrial translation [GO:0032543]; negative regulation of translation [GO:0017148]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; ribosome [GO:0005840] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VYSSHTGYPGGFR 1 7.3 0.93665 -0.54776 0 0 0 0 0 0 0 9.09334 0 0 0 0 Q9BYE2 TMPSD_HUMAN Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) TMPRSS13 MSP TMPRSS11 Homo sapiens (Human) proteolysis [GO:0006508] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] EVQVNLIDFK;IVGGALASDSK;NKPGVYTK 3 4.9 0.97539 -1.4335 0 0 0 0 0 0 11.5353 0 0 0 0 8.26524 Q9BYE3 LCE3D_HUMAN Late cornified envelope protein 3D (Late envelope protein 16) (Small proline-rich-like epidermal differentiation complex protein 6A) (Small proline-rich-like epidermal differentiation complex protein 6B) LCE3D LEP16 SPRL6A SPRL6B Homo sapiens (Human) keratinization [GO:0031424] cytosol [GO:0005829] GSGQQGGGSGCGHGSGGCC;QRPNSCDRGSGQQGGGSGCGHGSGGCC 2 29.3 0.83004 -0.024889 0 0 0 0 0 0 0 0 7.30561 0 4.75146 0 Q9BYE7 PCGF6_HUMAN Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) PCGF6 MBLR RNF134 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] metal ion binding [GO:0046872] LDRQLQDIVYKLVINLEER;SCIVRHFYYSNRCPK 2 9.7 0.95461 -0.90237 0 0 0 7.67652 0 7.46483 0 0 0 0 0 0 Q9BYE9 CDHR2_HUMAN Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24) CDHR2 PCDH24 PCLKC Homo sapiens (Human) brush border assembly [GO:1904970]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839] QLISVIIGLGVALLLVLVIMTMAFVCVRKSYNR 1 2.5 0.57883 0.18088 0 0 0 0 0 0 6.12862 0 0 0 0 0 Q9BYG0 B3GN5_HUMAN "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)" B3GNT5 Homo sapiens (Human) central nervous system development [GO:0007417]; glycolipid biosynthetic process [GO:0009247]; glycosphingolipid biosynthetic process [GO:0006688]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" GFFGQIYCRLMKIILLCK;KLAWEDQR;SGIRRTWGNENYVR 3 10.6 0.91589 -0.39051 0 8.75799 0 0 0 6.68426 7.87061 0 7.21645 0 9.61996 0 Q9BYG3 MK67I_HUMAN MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) NIFK MKI67IP NOPP34 Homo sapiens (Human) protein-containing complex assembly [GO:0065003]; rRNA metabolic process [GO:0016072]; rRNA transcription [GO:0009303] chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] EVAQVRKR 1 2.7 0.87066 -0.095167 0 0 0 0 0 0 0 0 0 0 0 9.25593 Q9BYG4 PAR6G_HUMAN Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) PARD6G PAR6G Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; regulation of cellular localization [GO:0060341] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160] ALGALRDEGPR 1 2.9 0.88753 -0.18299 0 0 0 0 8.50696 0 0 0 0 0 0 0 Q9BYG5 PAR6B_HUMAN Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) PARD6B PAR6B Homo sapiens (Human) axonogenesis [GO:0007409]; cell division [GO:0051301]; cell-cell junction assembly [GO:0007043]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; protein-containing complex assembly [GO:0065003]; regulation of cell migration [GO:0030334]; regulation of cellular localization [GO:0060341] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160] LLEEDGTIITL;NLIITVRPANQR 2 6.2 0.93706 -0.54239 10.4103 0 0 0 0 0 0 0 0 0 0 0 Q9BYG7 MSTRO_HUMAN Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29) MRO B29 C18orf3 Homo sapiens (Human) nucleolus [GO:0005730] IVLDLLVYGLYDPVNLEVIHESMKTLTVVLGKIQGK 1 17.1 0.40041 0.20949 0 0 0 0 0 0 0 7.60962 0 0 0 0 Q9BYH1 SE6L1_HUMAN Seizure 6-like protein SEZ6L KIAA0927 UNQ2542/PRO6094 Homo sapiens (Human) regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025] DPYWNDTEPLCR;IEFTSDQAR;IHVGEEK;PAARPPAAGLRGISLFLALLLGSPAAALER 4 5.7 0.96674 -1.2678 0 0 0 0 0 11.5948 0 0 0 0 9.86671 6.20811 Q9BYH8 IKBZ_HUMAN NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL) NFKBIZ IKBZ INAP MAIL Homo sapiens (Human) B cell proliferation [GO:0042100]; B cell receptor apoptotic signaling pathway [GO:1990117]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; chronic inflammatory response [GO:0002544]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; epithelial cell apoptotic process [GO:1904019]; establishment of skin barrier [GO:0061436]; execution phase of apoptosis [GO:0097194]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to wounding [GO:0090594]; isotype switching [GO:0045190]; keratinocyte activation [GO:0032980]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mRNA transcription by RNA polymerase II [GO:0042789]; plasma cell differentiation [GO:0002317]; positive regulation of inflammatory response [GO:0050729]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cisplatin [GO:0072718]; response to folic acid [GO:0051593]; response to Gram-positive bacterium [GO:0140459]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 cell differentiation [GO:0045063]; T-helper 17 cell differentiation [GO:0072539]; toll-like receptor signaling pathway [GO:0002224]; transcription preinitiation complex assembly [GO:0070897] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634] POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712] ELLLHIRSHKQK 1 1.7 0.86837 -0.09324 0 0 0 0 10.0272 0 0 0 0 0 0 0 Q9BYI3 HYCCI_HUMAN Hyccin (Down-regulated by CTNNB1 protein A) HYCC1 DRCTNNB1A FAM126A Homo sapiens (Human) myelination [GO:0042552]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] ASLPHGPMK;GVVEEWLSEFK;LIYVSER 3 5.2 0.9556 -0.98873 0 0 8.14226 0 6.91612 9.62892 0 0 0 5.93268 0 10.395 Q9BYJ0 FGFP2_HUMAN Fibroblast growth factor-binding protein 2 (FGF-BP2) (FGF-binding protein 2) (FGFBP-2) (37 kDa killer-specific secretory protein) (Ksp37) (HBp17-related protein) (HBp17-RP) FGFBP2 KSP37 UNQ425/PRO1065 Homo sapiens (Human) cell-cell signaling [GO:0007267] extracellular region [GO:0005576] growth factor binding [GO:0019838] NTDQTYWCEYR 1 4.9 0.80997 0.0097658 0 0 0 0 0 0 5.2581 0 0 0 0 0 Q9BYJ1 LOXE3_HUMAN Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) ALOXE3 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; sensory perception of pain [GO:0019233]; sphingolipid metabolic process [GO:0006665] cytosol [GO:0005829]; membrane [GO:0016020] "hepoxilin A3 synthase activity [GO:0051120]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; intramolecular hydroxytransferase activity [GO:0050486]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" MAVYRLCVTTGPYLR;TICQDSLPLLLDHRTRELR;YLPGFPMK 3 5.9 0.91549 -0.43408 0 0 9.34988 0 4.00018 0 0 0 0 0 0 0 Q9BYJ1 LOXE3_HUMAN Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) ALOXE3 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; sensory perception of pain [GO:0019233]; sphingolipid metabolic process [GO:0006665] cytosol [GO:0005829]; membrane [GO:0016020] "hepoxilin A3 synthase activity [GO:0051120]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; intramolecular hydroxytransferase activity [GO:0050486]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" GKQTSIRVQDCGR;TICQDSLPLLLDHRTRELR;YLPGFPMK 3 4.7 0.97236 -2.7858 0 0 0 0 0 0 0 10.7585 11.0995 0 0 0 Q9BYJ4 TRI34_HUMAN E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21) TRIM34 IFP1 RNF21 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LEADIREEK;LEADIREEKTSWK;LEEEEKK 3 4.1 0.98049 -1.6384 11.5252 0 0 0 0 0 0 0 0 0 0 10.7518 Q9BYJ9 YTHD1_HUMAN YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) YTHDF1 C20orf21 Homo sapiens (Human) immune system process [GO:0002376]; learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] EFEWNLK;SIKYSIWCSTEHGNK 2 3.9 0.93845 -0.57229 0 0 0 0 10.9488 0 0 0 0 0 0 0 Q9BYJ9 YTHD1_HUMAN YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) YTHDF1 C20orf21 Homo sapiens (Human) immune system process [GO:0002376]; learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] MGAATPTPR 1 4.6 0.93369 -0.51097 0 0 0 0 0 0 0 0 0 10.5753 0 0 Q9BYK8 HELZ2_HUMAN "3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 3.6.4.13) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AFDTRLQR;DLGQVSVGSFEILPGRQFR;FLERQTYNIPGGR;LVLAGDHMQVTPRLFSVARAR;LYENLPPAALR;NERLQNLGLDR;SITLHHR;SLLDFCEAQQTLVPAGQVRVCR;SPREGRPNQSLRSITLHHR;SQGSEWR;VLWEARK;VPSSTADFQVGVR 12 5.2 0.97827 -6.8422 11.1447 9.26545 0 0 6.78686 0 0 0 11.1349 7.0054 11.8654 0 Q9BYL1 SAM10_HUMAN Sterile alpha motif domain-containing protein 10 (SAM domain-containing protein 10) SAMD10 C20orf136 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] cytoplasmic side of plasma membrane [GO:0009898] DVDATAHFSFCR 1 5.9 0.92982 -0.46611 0 0 0 0 0 5.82683 0 0 0 9.46903 0 0 Q9BYN0 SRXN1_HUMAN Sulfiredoxin-1 (EC 1.8.98.2) SRXN1 C20orf139 SRX SRX1 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] "ATP binding [GO:0005524]; oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; sulfiredoxin activity [GO:0032542]" LVQSTLSDLR 1 7.3 0.89271 -0.22262 0 0 0 0 0 0 11.6564 0 0 0 0 0 Q9BYN7 ZN341_HUMAN Zinc finger protein 341 ZNF341 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NFDLQQHIRSHTGEKPFQCIACGR;VFPCERYLRR;YKCPFSTHTGCSK 3 5.5 0.9723 -2.687 0 0 0 7.52239 0 0 0 0 0 0 0 0 Q9BYN8 RT26_HUMAN "Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt)" MRPS26 C20orf193 RPMS13 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] KNYNWAITR;KTRHDPLAK 2 8.8 0.97041 -1.3347 0 0 0 0 0 0 11.9517 10.9151 0 0 0 0 Q9BYP7 WNK3_HUMAN Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) WNK3 KIAA1566 PRKWNK3 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; non-membrane-bounded organelle assembly [GO:0140694]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIIEGCIR;ENKGVPK;ESTADTRALNR;HPLPSPKNTSNKEISR;ISECASVETK;LPSNVLR;SVEMTEDDKVAESSPK;TREKKPAGCLEER;VTDPEVK 9 5.3 0.97461 -3.6608 0 0 10.0543 9.80827 11.254 0 0 0 0 9.68912 6.42225 11.3119 Q9BYP9 KRA99_HUMAN Keratin-associated protein 9-9 (Keratin-associated protein 9-5) (Keratin-associated protein 9.5) (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9) KRTAP9-9 KAP9.5 KAP9.9 KRTAP9-5 KRTAP9.5 KRTAP9.9 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] MTHCCSPCCQPTCCR;THCCSPCCQPTCCR;TTCFQPTCVSSCCQPSCC 3 21.4 0.045775 0.4967 0 3.78931 9.99548 0 0 5.96336 3.87823 8.63078 8.31949 5.55523 0 4.38922 Q9BYQ6 KR411_HUMAN Keratin-associated protein 4-11 (Keratin-associated protein 4-14) (Keratin-associated protein 4.11) (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14) KRTAP4-11 KAP4.14 KRTAP4-14 KRTAP4.11 KRTAP4.14 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] MVNSCCGSVCSHQGCGR 1 8.7 0.67466 0.16667 0 0 0 0 0 0 0 9.36361 0 0 0 0 Q9BYQ7 KRA41_HUMAN Keratin-associated protein 4-1 (Keratin-associated protein 4-10) (Keratin-associated protein 4.1) (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10) KRTAP4-1 KAP4.10 KRTAP4-10 KRTAP4.1 KRTAP4.10 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] ATCCRPSCCGSSC 1 8.9 0.80925 0.0096316 0 0 4.94237 0 0 0 0 0 0 0 0 0 Q9BYR5 KRA42_HUMAN Keratin-associated protein 4-2 (Keratin-associated protein 4.2) (Ultrahigh sulfur keratin-associated protein 4.2) KRTAP4-2 KAP4.2 KRTAP4.2 Homo sapiens (Human) cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] TTCYRPSCCVSTCCRPTCSSGSCC 1 17.6 0.71028 0.15634 0 0 0 0 0 0 0 5.57543 0 0 0 0 Q9BYS8 LRRC2_HUMAN Leucine-rich repeat-containing protein 2 LRRC2 Homo sapiens (Human) intracellular signal transduction [GO:0035556] EVMKAYIEDLK 1 3 0.92088 -0.44409 0 0 0 0 0 0 0 0 0 0 7.73193 0 Q9BYT3 STK33_HUMAN Serine/threonine-protein kinase 33 (EC 2.7.11.1) STK33 Homo sapiens (Human) manchette assembly [GO:1905198]; mitotic DNA damage checkpoint signaling [GO:0044773]; protein autophosphorylation [GO:0046777]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ADSGLDKKSTK;AGSSAVK;CPDCSSASQK;DLPSRTSNVER;KASQQQWGRGNFTEGK;LLEREVNILKSVK 6 13.2 0.97545 -3.4106 0 5.58006 0 0 0 7.08884 12.4485 12.2755 0 0 14.9978 0 Q9BYT8 NEUL_HUMAN "Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)" NLN AGTBP KIAA1226 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; regulation of gluconeogenesis [GO:0006111]; regulation of skeletal muscle fiber differentiation [GO:1902809] cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277] CLLAVRSLRR 1 1.4 0.77173 0.051759 0 0 0 0 0 6.65048 0 0 0 0 0 0 Q9BYT9 ANO3_HUMAN Anoctamin-3 (Transmembrane protein 16C) ANO3 C11orf25 TMEM16C GENX-3947 Homo sapiens (Human) calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; chloride transmembrane transport [GO:1902476]; detection of mechanical stimulus [GO:0050982]; detection of temperature stimulus [GO:0016048]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] ATEVFMCPLCDKNCSLQRLNDSCIYAK;DTFFSNATRSR;MQTYFRRIK;NCSLQRLNDSCIYAK;SMGRMQTYFRR 5 5.2 0.9802 -1.8702 0 0 0 0 4.5443 0 0 0 10.446 7.91337 10.1764 0 Q9BYV1 AGT2_HUMAN "Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (EC 2.6.1.18) (D-3-aminoisobutyrate-pyruvate aminotransferase) (D-AIBAT) (D-beta-aminoisobutyrate-pyruvate aminotransferase)" AGXT2 AGT2 Homo sapiens (Human) "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process, by transamination [GO:0019481]; N(omega),N(omega)-dimethyl-L-arginine catabolic process [GO:2001299]; positive regulation of nitric oxide biosynthetic process [GO:0045429]" mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] (R)-3-amino-2-methylpropionate-pyruvate transaminase activity [GO:0047305]; alanine-glyoxylate transaminase activity [GO:0008453]; beta-alanine:pyruvate transaminase activity [GO:0016223]; pyridoxal phosphate binding [GO:0030170] KCSCAPDCCQAKDQYIEQFK;SALTQHMER 2 5.6 0.87621 -0.12468 0 0 4.49371 0 0 0 0 10.214 0 0 0 0 Q9BYV2 TRI54_HUMAN Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30) TRIM54 MURF MURF3 RNF30 Homo sapiens (Human) cell differentiation [GO:0030154]; innate immune response [GO:0045087]; microtubule-based process [GO:0007017]; negative regulation of microtubule depolymerization [GO:0007026]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; Z disc [GO:0030018] microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VEHVAEMLR 1 2.5 0.91776 -0.40781 0 12.0473 0 0 0 0 0 0 0 0 0 0 Q9BYV6 TRI55_HUMAN Tripartite motif-containing protein 55 (EC 2.3.2.27) (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29) TRIM55 MURF2 RNF29 Homo sapiens (Human) diapedesis [GO:0050904]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; macrophage migration [GO:1905517]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein K48-linked ubiquitination [GO:0070936]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EIDFYREDEDEEEEEGGEGEK;EQQTMDNLEK;IIREIDFYREDEDEEEEEGGEGEK 3 6.2 0.91713 -0.4128 5.23691 0 0 0 6.15005 8.67786 0 6.05611 0 0 7.0082 0 Q9BYV8 CEP41_HUMAN Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) CEP41 TSGA14 Homo sapiens (Human) cilium assembly [GO:0060271]; protein polyglutamylation [GO:0018095]; protein transport [GO:0015031] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020] GPPLPAENKWR;LDTGNSMTKYTEK 2 6.4 0.98094 -2.031 12.7255 0 13.9945 0 0 0 13.2629 0 0 0 13.6508 0 Q9BYV9 BACH2_HUMAN Transcription regulator protein BACH2 (BTB and CNC homolog 2) BACH2 Homo sapiens (Human) import into nucleus [GO:0051170]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primary adaptive immune response involving T cells and B cells [GO:0090721]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DAACQRPHEDCENSAGEEEDEEEETMDSETAK;EKLLSERNQLK;LTSEQLEFIHDVR;LVCEKEK 4 7.3 0.95485 -0.97263 0 0 0 0 6.38102 0 0 11.246 10.1066 3.7476 0 0 Q9BYW1 GTR11_HUMAN "Solute carrier family 2, facilitated glucose transporter member 11 (Glucose transporter type 11) (GLUT-11)" SLC2A11 GLUT11 Homo sapiens (Human) D-glucose transmembrane transport [GO:1904659]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749] cell junction [GO:0030054]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119] GAVAMSSAIFTALGIVMGQVVGLSTTAATGLRGLGR 1 14.9 0.91663 -0.41588 0 0 0 0 0 0 0 0 0 0 10.8379 0 Q9BYW2 SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; mesoderm morphogenesis [GO:0048332]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; peptidyl-lysine trimethylation [GO:0018023]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of ossification [GO:0045778]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to alkaloid [GO:0043279]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; stem cell differentiation [GO:0048863]; transcription elongation by RNA polymerase II [GO:0006368] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] alpha-tubulin binding [GO:0043014]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; metal ion binding [GO:0046872]; protein-lysine N-methyltransferase activity [GO:0016279] DLRTSSYSK;GVASSRFLPK;IENVQKTGFIKGPMFK;ITTTEDFKHLAR;LNDSPTLKK;LSTEADTDTPK;MQCECTPLSK;NIHYYFMALK;SERGSRTNLSYSR;SESPFRETEPLVSPHQDK;SSQSYRHYSDHWEDERLESR;TLEHLPIPTKNMLEESKVLPIIQR 12 6.3 0.97311 -2.5885 6.97327 8.10899 10.9473 0 6.6632 0 11.42 10.325 0 9.42681 9.50428 0 Q9BYX2 TBD2A_HUMAN TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) TBC1D2 PARIS1 PP8997 TBC1D2A Homo sapiens (Human) positive regulation of GTPase activity [GO:0043547] anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096] ALEAAQQEK;ALEAAQQEKR;GPIRGWK;TAQEKVAALEQQVLMLTK;WAALGDLVPSAELKQLLRAGVPR 5 6.2 0.97386 -2.4237 8.58026 0 0 10.7529 7.35429 0 4.08559 0 0 0 0 0 Q9BYX4 IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] GLDLPCLKIR;ILELQMQSIMEKK;LAENPEYENEKLTK;MIDAYTHLETFYNEEK;SNGYSTDENFRYLISCFR;TVKENLDQLKNQIQEPCK;YLISCFRAR 7 8.9 0.97825 -2.1276 0 0 6.1372 9.1469 0 10.1047 0 0 0 0 10.5642 11.4941 Q9BYZ6 RHBT2_HUMAN Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83) RHOBTB2 DBC2 KIAA0717 Homo sapiens (Human) actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] EKEDYLHLK;RHLQFWK;TMWYPEIK;TMWYPEIKHFCPR 4 4 0.97417 -1.3945 0 0 0 10.0584 8.63681 0 0 0 0 0 0 0 Q9BYZ8 REG4_HUMAN Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV) REG4 GISP RELP Homo sapiens (Human) response to bacterium [GO:0009617] cytoplasm [GO:0005737]; extracellular region [GO:0005576] heparin binding [GO:0008201]; mannan binding [GO:2001065]; signaling receptor activity [GO:0038023] LLLLLSCLAK;QHFLCKYRP;SNCYGYFRK 3 17.7 0.93474 -0.53082 0 0 0 0 0 0 0 0 0 6.9913 0 0 Q9BYZ8 REG4_HUMAN Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV) REG4 GISP RELP Homo sapiens (Human) response to bacterium [GO:0009617] cytoplasm [GO:0005737]; extracellular region [GO:0005576] heparin binding [GO:0008201]; mannan binding [GO:2001065]; signaling receptor activity [GO:0038023] LLLLLSCLAK;NWSDAEVRNLLPAWPGLSR;SNCYGYFRK 3 28.4 0.98026 -1.5632 0 0 0 0 0 0 9.12848 0 0 0 0 0 Q9BZ19 ANR60_HUMAN Ankyrin repeat domain-containing protein 60 ANKRD60 C20orf86 Homo sapiens (Human) DLNDLVMK;SGARAGAQGCGGPR;VGSADSR;VKSGFRSEK 4 11 0.97585 -2.3059 0 11.2513 0 0 0 0 8.6709 9.79238 0 0 0 0 Q9BZ23 PANK2_HUMAN "Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)]" PANK2 C20orf48 Homo sapiens (Human) aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion organization [GO:0007005]; pantothenate metabolic process [GO:0015939]; phosphorylation [GO:0016310]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] LGAPMER;LVYFEPK;SIRKYLTSNVAYGSTGIR 3 5.6 0.97382 -1.401 0 10.5764 0 0 0 0 0 0 0 0 0 0 Q9BZ23 PANK2_HUMAN "Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)]" PANK2 C20orf48 Homo sapiens (Human) aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion organization [GO:0007005]; pantothenate metabolic process [GO:0015939]; phosphorylation [GO:0016310]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] MPAFIQMGRDK 1 3.9 0.97794 -1.5277 0 0 0 0 0 0 0 0 0 0 0 10.3325 Q9BZ29 DOCK9_HUMAN Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) DOCK9 KIAA1058 ZIZ1 Homo sapiens (Human) positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085] EDQLEYQEEMK;EVRLIAISVLKNLLIK;GNMNSAISVTMR;LIAISVLKNLLIKHSFDDR 4 2.2 0.97437 -2.4507 0 0 0 0 0 6.97005 0 10.129 0 0 0 0 Q9BZ67 FRMD8_HUMAN FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) FRMD8 FKSG44 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to plasma membrane [GO:0072659] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] AADVLVYLADDTVVPLAVENLPSLSAHELHR 1 6.7 0.71322 0.15354 0 0 0 0 0 0 5.33425 0 0 0 0 0 Q9BZ68 FR8P1_HUMAN Putative FERM domain-containing protein FRMD8P1 (FERM domain-containing 8 pseudogene 1) FRMD8P1 FKSG43 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] LPDIALDVFALWLVSPLLEVQLKPK 1 6.8 0.71232 0.15167 0 0 0 0 0 0 0 0 0 0 0 9.01221 Q9BZ71 PITM3_HUMAN "Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)" PITPNM3 NIR1 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661] cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; phosphatidylinositol transfer activity [GO:0008526]; phospholipase activity [GO:0004620]; receptor tyrosine kinase binding [GO:0030971] WVHLDTEITNSSGR 1 1.4 0.78671 0.017829 0 0 0 0 0 0 9.70672 0 0 0 0 0 Q9BZ72 PITM2_HUMAN "Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)" PITPNM2 KIAA1457 NIR3 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] calcium ion binding [GO:0005509]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971] DSDESSDDEFFDAHEDLSDTEEMFPK 1 1.9 0.71049 0.14778 0 0 0 0 0 0 0 0 0 0 0 8.70881 Q9BZ76 CNTP3_HUMAN Contactin-associated protein-like 3 (Cell recognition molecule Caspr3) CNTNAP3 CASPR3 KIAA1714 Homo sapiens (Human) cell adhesion [GO:0007155]; cell recognition [GO:0008037] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] FLPLAWNPR;LAGGAGR;LDKKPLKPIRDVISLK 3 2.5 0.50295 0.18859 0 0 3.20855 0 0 0 0 4.32531 0 0 0 0 Q9BZ95 NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) NSD3 WHSC1L1 DC28 Homo sapiens (Human) methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; histone H3K27 dimethyltransferase activity [GO:0140952]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 dimethyltransferase activity [GO:0140946]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537] CPQHCCSACSMEK;VQIQVADLSEIPR 2 1.8 0.61355 0.17448 0 12.3476 0 0 0 0 0 0 0 0 0 0 Q9BZ98 TTY12_HUMAN Putative transcript Y 12 protein TTTY12 TTY12 Homo sapiens (Human) MIDPETRHK 1 10 0.93368 -0.50519 0 10.2691 0 0 0 0 0 0 0 0 0 0 Q9BZA5 TXNG2_HUMAN "Putative gamma-taxilin 2 (Gamma-taxilin 2 pseudogene) (Taxilin gamma pseudogene, Y-linked)" TXLNGY CYorf15A CYorf15B TXLNG2P Homo sapiens (Human) syntaxin binding [GO:0019905] EEAGLCGLREK;LAALCKK 2 13.7 0.9722 -1.3628 0 6.87172 0 0 0 10.4132 0 0 0 0 0 0 Q9BZA7 PC11X_HUMAN Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) PCDH11X KIAA1326 PCDH11 PCDHX Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ADDVDSDGNR;VAGKSQR;VSRSSSAK 3 1.9 0.97864 -1.921 0 11.9458 0 4.5162 0 0 8.25531 0 0 0 0 0 Q9BZC1 CELF4_HUMAN CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 BRUNOL4 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; embryo development ending in birth or egg hatching [GO:0009792]; excitatory postsynaptic potential [GO:0060079]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; mRNA splice site recognition [GO:0006376]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of retina development in camera-type eye [GO:1902866]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904] BRE binding [GO:0042835]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002] DLKPLFEEFGKIYELTVLKDR;GPDGNSK;IYELTVLKDR;QQSEDDVRR 4 7.6 0.97972 -1.5397 13.2402 8.10491 0 12.5203 11.4699 0 14.0688 0 0 9.94892 0 0 Q9BZC7 ABCA2_HUMAN ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) ABCA2 ABC2 KIAA1062 Homo sapiens (Human) central nervous system myelin formation [GO:0032289]; ceramide translocation [GO:0099040]; cholesterol homeostasis [GO:0042632]; ganglioside metabolic process [GO:0001573]; glycosphingolipid metabolic process [GO:0006687]; intracellular sphingolipid homeostasis [GO:0090156]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of intracellular cholesterol transport [GO:0032384]; negative regulation of phospholipid biosynthetic process [GO:0071072]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sphingolipid biosynthetic process [GO:0090155]; negative regulation of steroid metabolic process [GO:0045939]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of post-translational protein modification [GO:1901873]; regulation of protein glycosylation [GO:0060049]; regulation of protein localization to cell periphery [GO:1904375]; regulation of protein localization to cell surface [GO:2000008]; regulation of steroid metabolic process [GO:0019218]; response to cholesterol [GO:0070723]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sphingomyelin metabolic process [GO:0006684]; sphingosine biosynthetic process [GO:0046512]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ceramide floppase activity [GO:0099038]; endopeptidase regulator activity [GO:0061135]; lipid transporter activity [GO:0005319]; nucleotide binding [GO:0000166] AYWRPGPNTGGR;HHTKVQYQLK;LGGNPLFR;LHRYGAITFGNVLK;LSVMEEDQACAMESR;MIEDLELSNK;QFHGLLVKRFHCAR;SYWLGSGRTEAWEWSWPWAR;TEMDEIRK;TILLSTHHMDEADLLGDR;VGQGSRK 11 5.6 0.97573 -5.0715 0 0 10.2528 0 0 9.81941 10.0003 10.1841 8.16747 0 0 0 Q9BZD2 S29A3_HUMAN Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3) SLC29A3 ENT3 UNQ717/PRO1380 Homo sapiens (Human) adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; dopamine transport [GO:0015872]; guanine transmembrane transport [GO:1903716]; inosine transport [GO:0035340]; norepinephrine transport [GO:0015874]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transmembrane transport [GO:1904082]; serotonin transport [GO:0006837]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; organic cation transmembrane transporter activity [GO:0015101]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213] TTSSSLR 1 1.5 0.90917 -0.30976 0 0 0 0 0 8.62425 0 0 0 0 0 0 Q9BZD4 NUF2_HUMAN Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1) NUF2 CDCA1 NUF2R Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore organization [GO:0051383]; meiotic chromosome segregation [GO:0045132]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; Ndc80 complex [GO:0031262]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940] microtubule binding [GO:0008017]; protein-containing complex binding [GO:0044877] EIQESLKTK;IVDSPEK;IVDSPEKLK 3 3.9 0.97348 -2.5482 0 13.7707 0 0 0 0 0 12.2123 12.175 0 0 0 Q9BZD7 TMG3_HUMAN Transmembrane gamma-carboxyglutamic acid protein 3 (Proline-rich gamma-carboxyglutamic acid protein 3) (Proline-rich Gla protein 3) PRRG3 PRGP3 TMG3 Homo sapiens (Human) blood coagulation [GO:0007596] extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ATRHHPSYAQNR 1 5.2 0.9224 -0.44708 0 0 0 0 0 0 0 0 0 9.67906 0 0 Q9BZE0 GLIS2_HUMAN Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) GLIS2 NKL Homo sapiens (Human) cell differentiation involved in kidney development [GO:0061005]; central nervous system development [GO:0007417]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" DAGYCCHWEGCAR;GFNARYK 2 3.8 0.22342 0.31113 0 0 0 7.49273 0 0 7.29756 7.45385 0 7.40659 0 0 Q9BZE3 BARH1_HUMAN BarH-like 1 homeobox protein BARHL1 FKSG31 Homo sapiens (Human) midbrain development [GO:0030901]; negative regulation of outer hair cell apoptotic process [GO:1905586]; neuron migration [GO:0001764]; outer hair cell apoptotic process [GO:1905584]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" AGSPALPK;KARTAFTDHQLAQLER 2 7.3 0.22985 0.29711 11.3078 0 0 0 0 0 0 0 0 0 0 11.243 Q9BZE4 GTPB4_HUMAN GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) GTPBP4 CRFG NOG1 Homo sapiens (Human) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosomal large subunit biogenesis [GO:0042273]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; preribosome binding [GO:1990275]; RNA binding [GO:0003723] HLLSGKRK;HVFDMKPKHLLSGK;VNEVLNR 3 3.6 0.97657 -2.249 0 0 0 0 0 0 0 9.2632 0 12.3786 0 0 Q9BZE7 EVG1_HUMAN UPF0193 protein EVG1 C22orf23 Homo sapiens (Human) DLEKEKQR;LREMEDIDHRR 2 8.8 0.97713 -1.4946 0 0 0 0 0 6.99481 0 12.0797 0 0 0 0 Q9BZE9 ASPC1_HUMAN Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9 Homo sapiens (Human) glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; positive regulation of protein modification process [GO:0031401]; regulation of D-glucose import [GO:0046324] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] GDLSRPEDADTSGPCCEHTQEK;MAAPAGGGGSAVSVLAPNGR 2 7.6 0.17837 0.33901 7.24565 0 0 0 0 0 0 0 0 0 0 0 Q9BZF1 OSBL8_HUMAN Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) OSBPL8 KIAA1451 ORP8 OSBP10 Homo sapiens (Human) fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]; positive regulation of D-glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein localization to nuclear pore [GO:0090204] cortical endoplasmic reticulum [GO:0032541]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] cholesterol binding [GO:0015485]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548] GILYGTMTLELGGTVNITCQK 1 2.4 0.6541 0.16939 0 0 0 0 7.39549 0 0 0 0 0 0 0 Q9BZF2 OSBL7_HUMAN Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) OSBPL7 ORP7 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; positive regulation of proteasomal protein catabolic process [GO:1901800]; regulation of autophagy [GO:0010506] autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; sterol transfer activity [GO:0120015] IEQLQRDR;ITFCKAK;SLEIVPVGTVNVSLPR 3 3.7 0.97031 -1.3444 0 0 0 0 5.00365 0 8.85655 0 0 0 0 0 Q9BZF3 OSBL6_HUMAN Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) OSBPL6 ORP6 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; regulation of cholesterol transport [GO:0032374] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; sterol transfer activity [GO:0120015] LAAAVATTVPFSATMSPVR;RFFVLDNGMLK;RYMEENNLEHIPKFFK;VIDANQR 4 5.7 0.91583 -0.43207 0 0 3.9013 0 0 0 11.8686 9.69091 0 0 8.73978 0 Q9BZF9 UACA_HUMAN Uveal autoantigen with coiled-coil domains and ankyrin repeats UACA KIAA1561 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of inflammatory response [GO:0050728]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779] AEYISLAEHEAK;ELSMCEMER;ELSMCEMEREKK;KVTEMEGQAK;LETREVVDLSK;LLDVTQKYTEK;NLTHMQDEVNVK;NLTHMQDEVNVKSHQR;SLEQQLADADR;YSVSEEEVKKNK 10 6.7 0.97615 -2.2637 12.4923 0 10.8035 9.84911 0 8.55298 0 9.24596 0 9.82967 8.38716 0 Q9BZG1 RAB34_HUMAN Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah) RAB34 RAB39 RAH Homo sapiens (Human) antigen processing and presentation [GO:0019882]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; Golgi to plasma membrane protein transport [GO:0043001]; lysosome localization [GO:0032418]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; vesicle [GO:0031982] GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267] DALQVAQEMKAEYWAVSSLTGENVR;INSDDSNLYLTASK;VTCACQEHRTGTVGFCK 3 23.6 0.94014 -0.58423 0 0 0 0 6.99989 0 0 0 7.07489 7.31089 0 0 Q9BZG8 DPH1_HUMAN 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) DPH1 DPH2L DPH2L1 OVCA1 Homo sapiens (Human) fibroblast proliferation [GO:0048144]; protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]; cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" LSKEVEAVVYLGDGR;SWGLILGTLGRQGSPK 2 7.1 0.96519 -1.1588 0 0 0 0 0 0 0 8.87477 0 0 0 0 Q9BZH6 WDR11_HUMAN WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) WDR11 BRWD2 KIAA1351 WDR15 Homo sapiens (Human) cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] AALFVEACLK;DLLNELESPK;GSILREVHLK;ILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPR 4 5.5 0.91546 -0.43396 0 6.23609 0 5.55505 0 0 10.2909 0 9.98556 0 0 11.6513 Q9BZI1 IRX2_HUMAN Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) IRX2 IRXA2 Homo sapiens (Human) cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AGAHPLESHYRSPGGGYEPK;SEDEDEDEGDATR;YDDLEDDEDDDEEGER 3 10.4 0.91759 -0.39895 0 0 6.70584 0 0 0 0 5.9073 6.87455 0 0 0 Q9BZI7 REN3B_HUMAN Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) UPF3B RENT3B UPF3X Homo sapiens (Human) "brain development [GO:0007420]; mRNA transport [GO:0051028]; neuron projection development [GO:0031175]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translation [GO:0045727]" centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] ASGQSCTLPKR;ELIAKKTTPLLSFLK 2 5.4 0.90782 -0.27665 0 0 9.1643 6.92434 0 0 0 0 0 0 0 0 Q9BZJ0 CRNL1_HUMAN Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) CRNKL1 CRN CGI-201 MSTP021 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] RNA binding [GO:0003723] GQRSVLQVPLPVPR;NIWDRAITTLPR;QDAQELFKNYTIFEK;TFEDNIRK;VIYKYALDRISK 5 7.2 0.96743 -1.3176 0 0 7.10559 0 8.63038 0 0 0 0 0 11.7047 11.4014 Q9BZL1 UBL5_HUMAN Ubiquitin-like protein 5 UBL5 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein modification process [GO:0036211]" Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein tag activity [GO:0031386] CNTDDTIGDLKK 1 16.4 0.93016 -0.48763 0 0 0 0 9.26188 0 0 0 0 0 0 0 Q9BZL4 PP12C_HUMAN Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) PPP1R12C LENG3 MBS85 Homo sapiens (Human) neuron projection morphogenesis [GO:0048812]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; stress fiber [GO:0001725] enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein kinase binding [GO:0019901] EQLRQWGAR;KQEDLRNQK;SYQMPVRDEESESQRK;TLYAELRRENER 4 5.9 0.97439 -3.5295 0 0 12.4422 0 0 0 0 0 0 0 10.8327 0 Q9BZM1 PG12A_HUMAN Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) PLA2G12A PLA2G12 FKSG38 UNQ2519/PRO6012 Homo sapiens (Human) arachidonate secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623] CYETCGK 1 3.7 0.91046 -0.31916 0 0 0 0 0 0 0 0 0 0 4.23657 3.31468 Q9BZM4 ULBP3_HUMAN UL16-binding protein 3 (ALCAN-gamma) (NKG2D ligand 3) (N2DL-3) (NKG2DL3) (Retinoic acid early transcript 1N) ULBP3 N2DL3 RAET1N Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] natural killer cell lectin-like receptor binding [GO:0046703] FLLFDSNNR;HGQQWCEVQSQVDQK;LAILPYLLFDWSGTGR;VLSMGHLEEQLYATDAWGK 4 24.2 0.69811 0.16147 0 0 0 8.07553 0 0 10.7522 0 0 0 0 5.1776 Q9BZM6 ULBP1_HUMAN UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I) ULBP1 N2DL1 RAET1I Homo sapiens (Human) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] natural killer cell lectin-like receptor binding [GO:0046703]; receptor ligand activity [GO:0048018] DVTMFFQK;FLLFDSNNR 2 7 0.92145 -0.44303 0 0 0 0 0 0 0 0 0 0 12.7184 0 Q9BZP6 CHIA_HUMAN Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; kinase binding [GO:0019900] MVSTPENRQTFITSVIKFLR 1 5.4 0.8523 -0.079704 0 0 0 0 0 0 0 0 5.79348 0 0 0 Q9BZP6 CHIA_HUMAN Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; kinase binding [GO:0019900] REAFEQEAK 1 2.9 0.86942 -0.09424 0 0 0 0 0 0 0 0 0 7.97613 0 0 Q9BZQ4 NMNA2_HUMAN Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2) NMNAT2 C1orf15 KIAA0479 Homo sapiens (Human) axon development [GO:0061564]; NAD biosynthetic process [GO:0009435]; negative regulation of cytoplasmic translation [GO:2000766]; nucleotide biosynthetic process [GO:0009165] axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; synapse [GO:0045202]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] DAADTDRIMNHSSILR 1 5.2 0.26142 0.26879 0 0 0 0 0 0 6.43796 0 0 0 9.78576 0 Q9BZQ6 EDEM3_HUMAN "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)" EDEM3 C1orf22 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; protein glycosylation [GO:0006486]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" GDIRPAIETHEMLYQVIKK;KALDFLWEK;KMGVSLIHLK;SSNLVGVTINIHTGDWVRK;VLRDVNLDNDVVVSVFETNIR 5 8.4 0.95915 -1.0389 10.0133 10.6208 0 0 6.38078 6.43102 0 0 0 0 0 0 Q9BZQ8 NIBA1_HUMAN Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) NIBAN1 C1orf24 FAM129A NIBAN GIG39 Homo sapiens (Human) negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] GLEGTIR;NDYAVESYENK 2 1.9 0.94428 -0.6314 0 0 6.78254 0 0 0 0 0 0 0 0 0 Q9BZR6 RTN4R_HUMAN Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) RTN4R NOGOR UNQ330/PRO526 Homo sapiens (Human) axonogenesis [GO:0007409]; cell surface receptor signaling pathway [GO:0007166]; corpus callosum development [GO:0022038]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]; neuronal signal transduction [GO:0023041]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of postsynapse assembly [GO:0150052] axonal growth cone [GO:0044295]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793] chondroitin sulfate binding [GO:0035374]; ganglioside GM1 binding [GO:1905573]; ganglioside GT1b binding [GO:1905576]; heparin binding [GO:0008201]; neuregulin receptor activity [GO:0038131]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] ASAGGSR 1 1.5 0.65419 0.16972 0 0 0 0 0 0 7.89918 0 0 0 0 0 Q9BZR9 TRIM8_HUMAN E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) TRIM8 GERP RNF27 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; protein K63-linked ubiquitination [GO:0070534]; stem cell population maintenance [GO:0019827]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605] identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] FNALHVEKPPAALHCVFCR;LTNIVEKFNALHVEKPPAALHCVFCRR 2 4.9 0.45512 0.19131 0 0 0 0 0 0 0 0 0 0 9.69422 8.6986 Q9BZS1 FOXP3_HUMAN "Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]" FOXP3 IPEX JM2 Homo sapiens (Human) "B cell homeostasis [GO:0001782]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; chromatin remodeling [GO:0006338]; establishment of endothelial blood-brain barrier [GO:0014045]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; myeloid cell homeostasis [GO:0002262]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytokine production [GO:0001818]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peripheral T cell tolerance induction [GO:0002851]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of DNA-templated transcription [GO:0006355]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of T cell anergy [GO:0002667]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory T cell differentiation [GO:0045066]; response to lipopolysaccharide [GO:0032496]; response to rapamycin [GO:1901355]; response to virus [GO:0009615]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell homeostasis [GO:0043029]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; tolerance induction to self antigen [GO:0002513]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta1 production [GO:0032905]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; NFAT protein binding [GO:0051525]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]" TLNEIYHWFTRMFAFFR 1 3.9 0.82942 -0.021785 0 0 0 0 0 0 0 0 0 5.7727 0 0 Q9BZV1 UBXN6_HUMAN UBX domain-containing protein 6 (UBX domain-containing protein 1) UBXN6 UBXD1 UBXDC2 Homo sapiens (Human) endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] LPDGCLLQGTFYARERLGAVYGFVR;SEAVERLSVLRTK 2 8.6 0.84116 -0.04486 0 0 0 6.05172 0 0 0 0 0 0 0 5.77566 Q9BZV3 IMPG2_HUMAN Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan) IMPG2 IPM200 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; protein localization [GO:0008104]; retina morphogenesis in camera-type eye [GO:0060042]; visual perception [GO:0007601] cell projection [GO:0042995]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; membrane [GO:0016020]; receptor complex [GO:0043235] extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540] ELIFDGGLGSGSGQK;VTNMMFSEDLFNK 2 2.3 0.32377 0.24559 0 3.77789 0 0 0 0 0 0 0 10.1743 0 0 Q9BZW2 S13A1_HUMAN Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1) SLC13A1 NAS1 NASI1 Homo sapiens (Human) sodium ion transport [GO:0006814]; sulfate transmembrane transport [GO:1902358]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] monoatomic anion:sodium symporter activity [GO:0015373]; sodium:sulfate symporter activity [GO:0015382] EMFKCGK;ISSKVELEKNSGMR;VASAYFK 3 4.7 0.93611 -0.51792 8.80864 7.33137 0 0 0 0 0 9.9343 0 0 0 0 Q9BZW5 TM6S1_HUMAN Transmembrane 6 superfamily member 1 TM6SF1 Homo sapiens (Human) lysosomal membrane [GO:0005765] DPAAYPK 1 1.9 0.93708 -0.53874 13.9871 0 0 10.639 0 0 0 0 0 0 0 11.5835 Q9BZW7 TSG10_HUMAN Testis-specific gene 10 protein (Testis development protein NYD-SP7) TSGA10 CEP4L Homo sapiens (Human) spermatogenesis [GO:0007283] centriole [GO:0005814]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] AHHRSPDRGLDR;DVAQFRNVVTQLEADLDITKR;EVEQHLNAERSYK;LLYENTEK;NILKSEESENRQMMEQLR;QLGTERFERER;SLEENLCYRDF;SQISTLHKSVVK;SVVKMEEELQKVQFEK 9 16.9 0.97536 -4.2158 8.39369 11.047 0 3.68605 0 9.39864 12.2917 0 0 0 0 0 Q9BZW8 CD244_HUMAN Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) CD244 2B4 Homo sapiens (Human) adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; positive regulation of granzyme B production [GO:0071663]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288]; signaling receptor activity [GO:0038023] AQNPARLSR;LGQVVTLILLLLLK;LGQVVTLILLLLLKVYQGK;VEKPRLQGQGKILDR 4 11.6 0.91755 -0.35228 0 3.17746 0 0 0 6.30519 4.8529 0 11.264 0 0 0 Q9BZX2 UCK2_HUMAN Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) UCK2 UMPK Homo sapiens (Human) CTP salvage [GO:0044211]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; identical protein binding [GO:0042802]; uridine kinase activity [GO:0004849] IVQLLGQNEVDYR 1 5 0.87341 -0.11628 0 0 0 0 0 8.96454 0 0 0 0 0 0 Q9BZY9 TRI31_HUMAN E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31) TRIM31 C6orf13 RNF Homo sapiens (Human) antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EATCPRHQEMFHYFCEDDGK;MASGQFVNK;QNMPPRQLLEDIKVVLCR;SEEFQFLNPTPVPLELEKKLSEAK 4 16.7 0.98012 -1.5645 6.5751 5.75774 0 4.41691 0 10.6656 0 0 0 0 0 9.8815 Q9BZZ2 SN_HUMAN Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) SIGLEC1 SN Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; clathrin-dependent endocytosis of virus by host cell [GO:0075512]; inflammatory response [GO:0006954]; negative regulation of type I interferon production [GO:0032480] early endosome [GO:0005769]; extracellular region [GO:0005576]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; virion binding [GO:0046790] LGLLLCR;LLHGDRLVASTLQGVGGPEGSSPR;NHVLLEDAHSHTLR;QVVSHSADPKLVEARFR;WLKDGVR;WLQEGPAASLSFLVATR 6 5 0.97568 -2.3159 0 3.60288 0 0 0 4.11153 6.904 0 0 0 9.44603 10.8529 Q9BZZ5 API5_HUMAN Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) API5 MIG8 Homo sapiens (Human) fibroblast apoptotic process [GO:0044346]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] fibroblast growth factor binding [GO:0017134]; RNA binding [GO:0003723] AIKFLSTKLK;SLQTVSGR 2 3.4 0.98037 -1.8134 0 0 0 0 9.02835 0 0 0 0 0 0 0 Q9C000 NLRP1_HUMAN "NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]" NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to UV-B [GO:0071493]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway [GO:0097193]; neuron apoptotic process [GO:0051402]; NLRP1 inflammasome complex assembly [GO:1904784]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to muramyl dipeptide [GO:0032495]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] CLLETLR;EYFYRYFTDERQAIR;FSRHVKK;LAGCGLTAEDCKDLAFGLR;TLFSPDDLRK 5 3.9 0.95503 -0.86619 9.7396 0 8.21252 0 0 0 0 0 0 12.5466 10.5252 0 Q9C002 NMES1_HUMAN Normal mucosa of esophagus-specific gene 1 protein (Protein FOAP-11) NMES1 C15orf48 Homo sapiens (Human) response to bacterium [GO:0009617] mitochondrion [GO:0005739]; nucleus [GO:0005634]; respiratory chain complex IV [GO:0045277] SFFQLLMKR 1 10.8 0.78389 0.030486 0 0 0 0 0 0 0 0 0 0 0 8.2253 Q9C004 SPY4_HUMAN Protein sprouty homolog 4 (Spry-4) SPRY4 Homo sapiens (Human) animal organ development [GO:0048513]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587] protein kinase inhibitor activity [GO:0004860] HFLLCEACGKCKCK;LLDHMAPPPVADQASPRAVRIQPK 2 12.7 0.96721 -1.3 0 0 0 0 10.4246 0 10.8369 10.5246 10.6706 0 10.7787 0 Q9C009 FOXQ1_HUMAN Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) FOXQ1 HFH1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle morphogenesis [GO:0031069]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KLEVFVPR;SPARQEERASPAGK 2 5.5 0.98067 -1.6607 0 0 0 0 0 0 0 0 0 11.9929 12.0649 0 Q9C019 TRI15_HUMAN E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7) TRIM15 RNF93 ZNF178 ZNFB7 Homo sapiens (Human) innate immune response [GO:0045087]; mesodermal cell fate determination [GO:0007500]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634] molecular sequestering activity [GO:0140313]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ELEQQIWK;VSEEVTR 2 3.2 0.95745 -1.0209 0 0 0 0 0 0 0 0 0 12.226 0 10.0832 Q9C026 TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) TRIM9 KIAA0282 RNF91 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; synaptic vesicle [GO:0008021] protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AAALKCQLCEK;CQLCEKAPK;EATVMCEQCDVFYCDPCRLR;VNKEHEHK 4 5.9 0.97523 -3.4447 0 0 7.29471 0 6.59774 0 0 0 0 13.4295 0 6.41508 Q9C029 TRIM7_HUMAN E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7) TRIM7 GNIP RNF90 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KELEDCEVFR;KELEDCEVFRSTEK;MAAVGPR;TFVLKGMLKK 4 6.1 0.96623 -1.2829 0 0 8.62417 0 0 0 10.0108 0 0 6.61428 0 9.10274 Q9C030 TRIM6_HUMAN Tripartite motif-containing protein 6 (EC 2.3.2.27) (RING finger protein 89) (RING-type E3 ubiquitin transferase TRIM6) TRIM6 RNF89 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked ubiquitination [GO:0070936]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VEQRELK 1 1.4 0.89867 -0.25752 12.2642 0 0 0 0 0 0 0 0 0 0 0 Q9C035 TRIM5_HUMAN Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) TRIM5 RNF88 Homo sapiens (Human) activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of gene expression [GO:0010468]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EEKASWK;ISYQPENIRPNR;THITYPSL 3 7.8 0.97725 -2.2301 0 0 8.35509 0 0 0 0 0 0 0 10.1041 0 Q9C037 TRIM4_HUMAN E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4) TRIM4 RNF87 Homo sapiens (Human) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LIRLLLYHFK;LLLYHFKQEEKLLK;LNQTIASLK;LVFSQEGR;TVCQIPLMK 5 8.6 0.97275 -2.5978 0 0 0 0 10.5686 0 0 13.1248 0 0 0 0 Q9C040 TRIM2_HUMAN Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523] cytoplasm [GO:0005737] translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ENPIEDDLIFR 1 1.5 0.88099 -0.14894 0 0 0 0 0 0 0 9.24596 0 0 0 0 Q9C075 K1C23_HUMAN "Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)" KRT23 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ALEEANMKLESRILK;ATMQNLNDR 2 5.7 0.96485 -1.1536 0 0 0 0 0 10.592 0 0 0 0 0 0 Q9C086 IN80B_HUMAN INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) INO80B HMGA1L4 PAPA1 ZNHIT4 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] DLSGGLGGQEEEEEQR;TAATSGR 2 6.5 0.47611 0.19071 0 0 0 9.34392 0 0 0 0 0 0 8.14001 0 Q9C091 GRB1L_HUMAN GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein) GREB1L C18orf6 KIAA1772 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac ventricle development [GO:0003231]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; mesonephric duct development [GO:0072177]; metanephros development [GO:0001656]; morphogenesis of an epithelium [GO:0002009]; paramesonephric duct development [GO:0061205]; uterus development [GO:0060065] membrane [GO:0016020] DMSSEEQSLYYR;LPLVSDK;RETVSIMLTK 3 1.5 0.96338 -1.0965 0 7.6532 0 0 0 0 0 0 0 12.0997 0 0 Q9C093 SPEF2_HUMAN Sperm flagellar protein 2 (Protein KPL2) SPEF2 KIAA1770 KPL2 Homo sapiens (Human) brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] EKRFHDQIAVER;EKSPQMGANK;EQLTELEKR;EVLWQNRIFR;HPFIQDLISNYSDYKFPDIKIILQR;HVKEDLAHLHFEK;LDIINESWLQDTLGMTMNHFFSLMQAELNR;LLYQLYIALQKKK;SFAKAFSSGYLLGEVLHK 9 7.7 0.9745 -3.6758 8.89309 6.79585 0 0 7.61228 0 0 0 0 9.43542 9.40278 9.77635 Q9C093 SPEF2_HUMAN Sperm flagellar protein 2 (Protein KPL2) SPEF2 KIAA1770 KPL2 Homo sapiens (Human) brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] HPFIQDLISNYSDYKFPDIKIILQR;NIVLTHLIK 2 5.5 0.91286 -0.32193 0 0 0 0 0 0 0 0 0 0 3.59144 0 Q9C098 DCLK3_HUMAN Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] APSPRLR;GDHRCGETETPK;WEPEPSSKPPREATLEER 3 5.7 0.95518 -0.87954 0 0 0 0 3.40966 0 0 0 0 0 6.37926 10.6633 Q9C099 LRCC1_HUMAN Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein) LRRCC1 CLERC KIAA1764 Homo sapiens (Human) cell division [GO:0051301] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] EAAAAVVAAEAEVENEDGDSSCGDVCFMDK;ESLIFGLRTERK;EVELEEIRK;IIDDQTETIR;IKCKIIDDQTETIR;KVWGHELAQQGSSLAQNRGK;LERHNER;LERHNERK;LKDCLQEK;LTVELMK;TLEKMERQK 11 11.2 0.97671 -4.9502 12.1393 0 11.3124 0 9.72136 4.69672 9.26186 7.3924 0 10.0827 0 0 Q9C0A0 CNTP4_HUMAN Contactin-associated protein-like 4 (Cell recognition molecule Caspr4) CNTNAP4 CASPR4 KIAA1763 Homo sapiens (Human) "cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]" cell projection [GO:0042995]; presynaptic membrane [GO:0042734] AGLLLFSELQLISGGILLFLSDGKLK;YQEPDVVNFDFK 2 2.9 0.83538 -0.031559 11.3919 0 0 0 0 0 7.99107 0 0 8.52634 0 0 Q9C0A1 ZFHX2_HUMAN Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2) ZFHX2 KIAA1056 KIAA1762 ZNF409 Homo sapiens (Human) adult behavior [GO:0030534]; regulation of neuron differentiation [GO:0045664]; regulation of sensory perception of pain [GO:0051930]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" CKLCCYGTQLK;EALASHLRSSAHRR;NSCKTLKCPK;SLPEAEWK;SVLHQTRSRGTK;TDKHAQK;TPAHRDAQAQRR 7 2.9 0.97492 -3.8451 8.40926 0 6.46972 10.2826 0 0 0 9.16146 8.93286 11.9446 0 0 Q9C0A6 SETD5_HUMAN Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) SETD5 KIAA1757 Homo sapiens (Human) cognition [GO:0050890]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of synapse assembly [GO:0051963] chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] LVPKPPPAKPSRPRPK;SSLPSDLRTISLPSAGQSAVYQASR;YSYQLLQCDSPR 3 3.7 0.8151 -0.0039206 0 0 3.64501 0 0 0 0 0 4.16197 9.59623 0 0 Q9C0B0 UNK_HUMAN RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) UNK KIAA1753 ZC3H5 ZC3HDC5 Homo sapiens (Human) cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] QWEESWKQAK;TEQCPLFVQHK;TEQQFHPEIYK 3 4 0.97738 -2.1711 0 0 0 0 0 10.3525 0 0 8.92223 0 0 11.22 Q9C0B1 FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) FTO KIAA1752 Homo sapiens (Human) adipose tissue development [GO:0060612]; DNA alkylation repair [GO:0006307]; mRNA destabilization [GO:0061157]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; snRNA processing [GO:0016180]; temperature homeostasis [GO:0001659] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; transferase activity [GO:0016740]; tRNA demethylase activity [GO:1990984] DLLTPVSR;ILIGNPGCTYK 2 3.8 0.96386 -1.1825 0 0 0 0 0 0 0 0 0 0 8.76245 0 Q9C0B2 CFA74_HUMAN Cilia- and flagella-associated protein 74 CFAP74 C1orf222 KIAA1751 Homo sapiens (Human) axoneme assembly [GO:0035082] axoneme [GO:0005930]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] EEMECHEYMR;EQEKKEEMECHEYMR;FSMHLDSLSSTR;ILKEEAEEEK;LSSLLTYEDK;SEINRCFK;TWNYISDFCKK 7 4.2 0.95122 -0.70608 0 13.3654 13.3778 10.1288 10.2757 11.0792 0 0 0 12.2168 9.35218 5.78884 Q9C0B5 ZDHC5_HUMAN Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) ZDHHC5 KIAA1748 ZNF375 Homo sapiens (Human) innate immune response [GO:0045087]; lipid transport [GO:0006869]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of pattern recognition receptor signaling pathway [GO:0062208]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] "dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]" palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] FYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRR 1 4.8 0.85302 -0.079986 0 0 9.82955 0 0 0 0 0 0 0 0 0 Q9C0B7 TNG6_HUMAN Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7) TANGO6 KIAA1746 TMCO7 Homo sapiens (Human) protein secretion [GO:0009306] membrane [GO:0016020] APAWLRRLCGQLLSER;LLTPAEEVLTEEER 2 2.7 0.80818 0.011421 9.13199 0 0 0 0 0 8.61519 0 0 0 0 0 Q9C0B9 ZCHC2_HUMAN Zinc finger CCHC domain-containing protein 2 ZCCHC2 C18orf49 KIAA1744 Homo sapiens (Human) cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] DTDSNSEDSGNPSTTR;GEDGDGEQDAEK;HDGRESFESEEEK;NGNVSCYNCGVSGHYAQDCK 4 5.2 0.95605 -0.83999 0 0 0 10.3474 0 5.31321 0 0 7.27891 0 0 0 Q9C0C2 TB182_HUMAN 182 kDa tankyrase-1-binding protein TNKS1BP1 KIAA1741 TAB182 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004] adherens junction [GO:0005912]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] LWGSRLTFNHDGSSRYGPR;VNLFPGLSPSALK 2 1.9 0.97435 -1.424 0 0 0 11.4084 7.88423 0 10.6812 10.6344 10.7808 0 0 0 Q9C0C4 SEM4C_HUMAN Semaphorin-4C SEMA4C KIAA1739 SEMAI UNQ5855/PRO34487 Homo sapiens (Human) axon guidance [GO:0007411]; cell migration in hindbrain [GO:0021535]; cerebellum development [GO:0021549]; muscle cell differentiation [GO:0042692]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of cell migration [GO:0030335]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of postsynapse assembly [GO:0150052]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] IVPGHAR;LHLGGGR;MAPHWAVWLLAARLWGLGIGAEVWWNLVPRK;NMGPHHSMK 4 6.5 0.88212 -0.16564 7.53722 6.10005 0 0 0 0 7.44361 0 7.55819 0 10.7297 0 Q9C0C6 CIPC_HUMAN CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) CIPC KIAA1737 Homo sapiens (Human) negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; rhythmic process [GO:0048511] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] APQAWAK;SDSRNYLPILNSYTKIAPHPGK;TKELIRQNQATQVELDQLK 3 12 0.84662 -0.068055 0 0 7.5462 0 0 8.88374 0 0 7.34145 0 0 0 Q9C0C9 UBE2O_HUMAN (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) UBE2O KIAA1734 Homo sapiens (Human) "positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IMSCSPDTQCSR;ITRDFKPGDR;LNPNLYDNGK;SVVPRDVVR 4 3.2 0.9764 -2.2854 0 0 0 0 5.92816 10.1372 0 0 0 0 7.58834 0 Q9C0D0 PHAR1_HUMAN Phosphatase and actin regulator 1 PHACTR1 KIAA1733 RPEL1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; cerebral cortex development [GO:0021987]; dendrite arborization [GO:0140059]; regulation of neuron migration [GO:2001222]; stress fiber assembly [GO:0043149] cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] ADKPWTR;EEEEEEEDEDDDSSLYTSSLAMK;TLAMTMQR 3 6.6 0.91058 -0.29899 0 0 7.21189 0 0 0 0 0 0 11.3702 0 0 Q9C0D2 CE295_HUMAN Centrosomal protein of 295 kDa CEP295 KIAA1731 Homo sapiens (Human) cell projection organization [GO:0030030]; centriole replication [GO:0007099]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of protein acetylation [GO:1901985]; regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] EIPRLQDRLLSLSKPILPQQDNMTAQLDAQR;KAIRSIQEVQEELLLQR;LNKSESAEHTIPSLFLPK;LSPNEEAFILKEDYER;LSPNEEAFILKEDYERR;QLLEYQTMLKGR;QLQQEDLAR;RLEELQK;RQTVAQMPPQLVELPYKR;TWHIKARK 10 5.3 0.97612 -4.4935 14.5322 0 10.6007 0 0 10.598 0 9.97571 0 0 8.87731 0 Q9C0D3 ZY11B_HUMAN Protein zyg-11 homolog B ZYG11B KIAA1730 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ISAVAFRK;TKPEILK 2 2 0.97384 -1.4109 0 0 11.2738 0 0 0 0 0 0 0 0 0 Q9C0D4 Z518B_HUMAN Zinc finger protein 518B ZNF518B KIAA1729 Homo sapiens (Human) chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QGRLLSR 1 0.7 0.60194 0.1776 0 0 0 0 0 0 8.2529 7.77294 0 0 0 0 Q9C0D5 TANC1_HUMAN "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; regulation of postsynapse organization [GO:0099175]; visual learning [GO:0008542] axon terminus [GO:0043679]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] CQIPVHSQENR;IISKFPAWLKLIVTVR;LLLERGCDVNLSDK;LPWHNTAGGRAQEVK;QLQRSQQQK 5 3.5 0.973 -2.5945 0 0 0 0 8.41562 9.60162 0 8.75509 6.83479 9.06929 11.8561 0 Q9C0D6 FHDC1_HUMAN FH2 domain-containing protein 1 (Inverted formin-1) FHDC1 INF1 KIAA1727 Homo sapiens (Human) actin filament polymerization [GO:0030041]; cilium assembly [GO:0060271]; Golgi ribbon formation [GO:0090161]; stress fiber assembly [GO:0043149] actin filament [GO:0005884]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874] actin binding [GO:0003779]; microtubule binding [GO:0008017] ENIQRDGELCQQMEDFLQFAIEKLR;KDVVAPK;SSSENDVELLTKK;TLNSSFREAR 4 4.8 0.92162 -0.44314 6.01855 0 10.7969 0 0 9.29122 0 0 0 0 6.91839 0 Q9C0D7 ZC12C_HUMAN Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) ZC3H12C KIAA1726 MCPIP3 Homo sapiens (Human) cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] CKYYHPER;FIVKLAFESDGIIVSNDNYR;GIKLAVDWFLERGHK;KPPDVVREYQTK;VVCYDDRFIVKLAFESDGIIVSNDNYR 5 7 0.97476 -3.4615 13.2526 0 10.9547 0 12.4607 0 5.8623 0 6.71932 2.60587 0 7.60652 Q9C0E2 XPO4_HUMAN Exportin-4 (Exp4) XPO4 KIAA1721 Homo sapiens (Human) positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] EQILLAVAVIVKRGSLDK;ETLLDSRVMELFFTVHR;LLESWLTLVQDDKHFHK;SAALEEVLDKDDMVYMEAYDK;WAKTYLLVDEK 5 7.3 0.95399 -0.90576 7.16199 0 7.59813 7.26632 0 8.97636 8.68552 0 0 0 0 12.2024 Q9C0E4 GRIP2_HUMAN Glutamate receptor-interacting protein 2 (GRIP-2) GRIP2 KIAA1719 Homo sapiens (Human) "artery smooth muscle contraction [GO:0014824]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; Notch signaling pathway [GO:0007219]; positive regulation of blood pressure [GO:0045777]; vesicle-mediated transport in synapse [GO:0099003]" "cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]" glutamate receptor binding [GO:0035254] LRHDEIITLLK 1 1.1 0.88591 -0.18229 0 0 0 0 0 0 0 0 0 0 5.35562 0 Q9C0E8 LNP_HUMAN Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) LNPK KIAA1715 LNP Homo sapiens (Human) blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; regulation of chondrocyte differentiation [GO:0032330] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] EEFEYIAFRCAYCFFLNPARK;ILEEVMEKETYK;LQKLWVGR;MGGLFSR;TERNNEALDDLK 5 14 0.97266 -2.7493 0 0 0 8.04385 0 7.2181 0 0 8.38716 0 0 0 Q9C0F0 ASXL3_HUMAN Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3) ASXL3 KIAA1713 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of transcription by RNA polymerase II [GO:0045944] PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] LGMSREESVK;QPPVTMETTK;VPPLKIQLSKIGPPFIIK 3 1.7 0.97078 -1.3434 0 0 0 0 5.22832 0 0 0 0 0 0 0 Q9C0F1 CEP44_HUMAN Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3) CEP44 KIAA1712 Homo sapiens (Human) centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle pole [GO:0000922] microtubule binding [GO:0008017] DQFNYKPILTK;VMVDENTWTNLLSRVTLLETEMLLSK 2 9.5 0.94127 -0.61416 6.48708 0 0 0 0 0 0 0 0 0 0 0 Q9C0F3 ZN436_HUMAN Zinc finger protein 436 ZNF436 KIAA1710 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EVHTGIRYHICSHCGK;VHTGERPYKCDECGK 2 6.6 0.91599 -0.4314 7.24479 0 0 0 0 0 0 0 0 0 0 0 Q9C0G0 ZN407_HUMAN Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] CSICGHLFSSCSDLEK;GGFVQILTKQPFPKK;LDTLVTSEGLLEK;REMTRHAATEK;SSTVLTRHIK;TSAQEMVSLDLERESPFPPK 6 3.8 0.97644 -2.2504 4.40817 0 0 0 7.4614 7.98613 0 0 0 9.77758 0 0 Q9C0G6 DYH6_HUMAN Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6) DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALAIQCVVFNCSDGLDYK;AVKSVLVMAGSLKR;ELTKIPIFSLFRK;ENIKPQILAKLQK;HGVMLVGPTGGGK;IIKLTDSNFLRILENSIR;KMQIHRPYVEVFSPSPPK;LAEVTERLGEFR;LEMEGASESLFVK;LILIKCCKEEK;LLEYDKENIKPQILAK;LSRFMFEGREIK;LTAALEDEQVRWEESIQK;MKHEDKHMR;SVIAKGLLNK;TANVLQDYLDDYNLTNPK;VTNEPPK;VVEPKRQK;WEQEYLYHR;YVDEGLHFINK;YYTTPTSYLELINLYLSMLSEKRK 21 6.6 0.9782 -7.715 0 12.4273 11.5054 0 0 9.4762 0 8.42559 12.9748 0 10.0556 11.4591 Q9C0H5 RHG39_HUMAN Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) postsynapse organization [GO:0099173]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] AALTGAK;MVLCYLIRFLQVFVQPANVAVTK;RAEGEAEGARGAAEPFLAQAR;TVWHRPQGCDIIPLAK;WNSGAKERMLIK 5 7.3 0.95531 -0.86131 13.1742 8.89124 5.95371 0 10.6306 11.6809 12.5507 11.5077 12.3301 7.85786 0 11.6138 Q9C0H6 KLHL4_HUMAN Kelch-like protein 4 KLHL4 KIAA1687 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] centriolar satellite [GO:0034451]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IWTVMPPMSTHR;LLMEAMK;SEEQFHVINHAEQTLR;TNSWLHIGTMNGR 4 6.7 0.88858 -0.18838 0 0 0 8.03826 0 0 5.25905 0 9.50337 8.14246 0 0 Q9C0H9 SRCN1_HUMAN SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) SRCIN1 KIAA1684 P140 SNIP Homo sapiens (Human) exocytosis [GO:0006887]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of protein tyrosine kinase activity [GO:0061098]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synapse [GO:0045202] protein kinase binding [GO:0019901] AVSVEAAERDWEEK;DEARNVFYELEDVR;DEDDEDR;GLQNSASDLR;GVTDTLAQIRR;KAESEELEVQKPQVKLR;NVFYELEDVRDIQDR 7 6.6 0.95521 -0.97712 0 12.5358 0 7.79636 6.52931 4.64887 0 10.3977 8.17123 0 0 8.76404 Q9C0I1 MTMRC_HUMAN Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) MTMR12 KIAA1682 PIP3AP Homo sapiens (Human) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829]; sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529] DLRVFQFCLRYTK;LINSSDELQDNFR;NPLYVEKPKLDK;VFQFCLRYTK 4 5.1 0.97244 -2.765 0 0 6.82757 0 0 0 10.0832 0 0 0 0 0 Q9C0I3 CCSE1_HUMAN Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) CCSER1 FAM190A KIAA1680 Homo sapiens (Human) AIHTPTEDR;AIHTPTEDRFR;EGRFIER;EKDELISQLQEELGK;KQRAGSSSSK;LGFYEQHKAIAEHVK 6 6.4 0.97602 -5.0569 0 10.2031 0 0 0 8.63045 0 9.42815 0 0 0 0 Q9C0I4 THS7B_HUMAN Thrombospondin type-1 domain-containing protein 7B THSD7B KIAA1679 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036] plasma membrane [GO:0005886] FTPCSTNCEATKSR;VTFKHQSYK 2 1.4 0.97309 -2.9638 0 0 0 0 0 0 0 0 0 0 8.34354 0 Q9C0J8 WDR33_HUMAN pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) WDR33 WDC146 Homo sapiens (Human) mRNA 3'-end processing [GO:0031124]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283] collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] GGPLPQEEKWR;GGRKGLLPTPDEFPR;MFQAHKEAIR;NLKEELQVFRGHK 4 3.7 0.97889 -1.9159 0 10.582 0 7.20124 0 0 0 0 0 0 10.6004 9.38448 Q9C0J8 WDR33_HUMAN pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) WDR33 WDC146 Homo sapiens (Human) mRNA 3'-end processing [GO:0031124]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283] collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] DTCFHHCR;MFQAHKEAIR 2 7 0.87862 -0.14057 0 8.65907 0 0 5.59842 0 0 0 0 0 0 0 Q9C0J9 BHE41_HUMAN Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1) BHLHE41 BHLHB3 DEC2 SHARP1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; MRF binding [GO:0043426]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" EVLQYLSRFESWTPREPR 1 3.7 0.86537 -0.086936 0 0 0 0 0 7.98709 0 0 0 0 0 0 Q9GZL7 WDR12_HUMAN Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) WDR12 Homo sapiens (Human) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]" "nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021] IWSLEGKSIMTIVGHTDVVK 1 4.7 0.81804 -0.01737 0 0 0 0 0 0 0 0 0 0 9.26404 0 Q9GZL8 BPEC1_HUMAN Putative BPES syndrome breakpoint region protein (BPES candidate 1) BPESC1 Homo sapiens (Human) ISSLCGLGFPSR 1 10.3 0.94222 -0.59533 0 0 0 0 0 10.0847 0 0 0 0 0 0 Q9GZM6 OR8D2_HUMAN Olfactory receptor 8D2 (Olfactory receptor OR11-303) (Olfactory receptor-like protein JCG2) OR8D2 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] MSVLSFCR 1 2.6 0.92857 -0.4732 0 0 0 0 8.58579 0 0 0 0 0 0 0 Q9GZM7 TINAL_HUMAN Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230 Homo sapiens (Human) endosomal transport [GO:0016197] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236] DEAGPAPPCMMHSRAMGR;ITGWGEETLPDGR;LDGAWWFLR;YCQEQDLCCR 4 10.7 0.97764 -1.518 0 0 0 0 0 0 0 0 0 8.34585 0 6.1641 Q9GZM8 NDEL1_HUMAN Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) NDEL1 EOPA MITAP1 NUDEL Homo sapiens (Human) cell migration [GO:0016477]; central nervous system neuron axonogenesis [GO:0021955]; centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; inner cell mass cell proliferation [GO:0001833]; insulin receptor signaling pathway [GO:0008286]; lysosome localization [GO:0032418]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neurofilament cytoskeleton organization [GO:0060052]; neuron projection extension [GO:1990138]; positive regulation of GTPase activity [GO:0043547]; positive regulation of ruffle assembly [GO:1900029]; radial glia-guided pyramidal neuron migration [GO:0140650]; regulation of intracellular protein transport [GO:0033157]; regulation of neuron projection development [GO:0010975]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; axon hillock [GO:0043203]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; neurofilament cytoskeleton [GO:0060053]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] DLQADNQR;VGALESK 2 4.3 0.91404 -0.39033 0 0 0 0 0 0 0 0 9.86929 0 0 0 Q9GZN2 TGIF2_HUMAN Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) TGIF2 Homo sapiens (Human) amacrine cell differentiation [GO:0035881]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nodal signaling pathway [GO:0038092]; positive regulation of amacrine cell differentiation [GO:1902871]; regulation of DNA-templated transcription [GO:0006355]; regulation of gastrulation [GO:0010470] centrosome [GO:0005813]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ESVKILRDWLYLHR;LLPDMLR 2 8.9 0.91848 -0.40413 0 0 0 0 0 0 0 8.95155 0 0 8.37743 0 Q9GZN4 BSSP4_HUMAN Brain-specific serine protease 4 (BSSP-4) (EC 3.4.21.-) (Serine protease 22) (Serine protease 26) (Tryptase epsilon) PRSS22 BSSP4 PRSS26 SP001LA UNQ302/PRO343 Homo sapiens (Human) positive regulation of peptidase activity [GO:0010952]; proteolysis [GO:0006508] extracellular space [GO:0005615] peptidase activator activity [GO:0016504]; serine-type endopeptidase activity [GO:0004252] NGTHHCAGSLLTSR;VGVAWVEPHPVYSWK 2 9.1 0.87387 -0.10565 0 8.57969 0 0 0 0 10.3844 0 0 0 0 0 Q9GZP0 PDGFD_HUMAN "Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]" PDGFD IEGF SCDGFB MSTP036 UNQ1899/PRO4345 Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139] growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161] CGGNCGCGTVNWRSCTCNSGK;NLLLTWR 2 7.6 0.91791 -0.40608 0 0 0 0 3.59264 0 0 0 12.2898 0 5.1935 0 Q9GZP1 NRSN2_HUMAN Neurensin-2 NRSN2 C20orf98 Homo sapiens (Human) nervous system development [GO:0007399] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] MMPSCNR;MPSCNRSCSCSR 2 6.4 0.91703 -0.35613 0 0 4.42499 0 0 0 6.44226 0 0 0 0 0 Q9GZP4 PITH1_HUMAN PITH domain-containing protein 1 PITHD1 C1orf128 AD039 HT014 PP603 Homo sapiens (Human) penetration of cumulus oophorus [GO:0061956]; penetration of zona pellucida [GO:0007341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm cytoplasmic droplet [GO:0097598] DLTGELEYATK;EGSGRVFKPWEER;VFYIGLRGEWTELR 3 18.1 0.98112 -1.7 0 0 0 0 0 0 0 0 0 0 9.71961 0 Q9GZP8 IMUP_HUMAN Immortalization up-regulated protein (Hepatocyte growth factor activator inhibitor type 2-related small protein) (H2RSP) (HAI-2-related small protein) IMUP C19orf33 Homo sapiens (Human) cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GLGKGRR;SEAGAGPGPK 2 20 0.031423 0.57403 8.6249 8.56476 0 9.15664 0 0 0 0 0 0 0 0 Q9GZQ3 COMD5_HUMAN COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) COMMD5 HT002 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] FEVPTAK 1 3.1 0.90953 -0.31678 0 0 0 0 0 0 8.24189 0 0 0 0 0 Q9GZR1 SENP6_HUMAN Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) SENP6 KIAA0797 SSP1 SUSP1 FKSG6 Homo sapiens (Human) protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] SUMO-specific endopeptidase activity [GO:0070139] VILPGAKIPKITNLK 1 1.3 0.76461 0.066498 0 0 0 3.21017 6.60751 0 0 0 0 0 0 0 Q9GZR2 REXO4_HUMAN RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) REXO4 PMC2 XPMC2H Homo sapiens (Human) DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] EVAEMLK;IIQQNKK;ILVGHALHNDLKVLFLDHPKK;QKSQAPEKPLVISQMGSKK 4 12.8 0.9717 -1.3556 0 11.8746 0 0 0 0 10.7167 0 0 10.8602 0 0 Q9GZR7 DDX24_HUMAN ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) DDX24 Homo sapiens (Human) RNA metabolic process [GO:0016070] membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LDILGAAETGSGK;NVATEGTSTQK;QLRCLVVDEADRMVEK;TWIPEVHDQK;VQHVIHYQVPR 5 7.1 0.97591 -1.454 0 0 0 0 0 0 0 0 0 9.24272 9.26948 0 Q9GZS9 CHST5_HUMAN Carbohydrate sulfotransferase 5 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha) (GST4-alpha) (Intestinal N-acetylglucosamine-6-O-sulfotransferase) (I-GlcNAc6ST) (Intestinal GlcNAc-6-sulfotransferase) (hIGn6ST) (N-acetylglucosamine 6-O-sulfotransferase 3) (GlcNAc6ST-3) (Gn6st-3) CHST5 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] ALCSPPACSAFPRGTISK;NLSAFFNWATSR 2 7.3 0.9509 -0.6663 0 0 0 0 6.91755 0 7.35067 0 10.5425 0 0 0 Q9GZT3 SLIRP_HUMAN "SRA stem-loop-interacting RNA-binding protein, mitochondrial" SLIRP C14orf156 DC23 DC50 PD04872 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; single fertilization [GO:0007338]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; sperm flagellum [GO:0036126] RNA binding [GO:0003723] EHFAQFGHVRRCILPFDK;RCILPFDK 2 16.5 0.97125 -1.3465 10.7125 0 0 0 0 0 11.2483 0 10.5425 0 0 0 Q9GZT4 SRR_HUMAN Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR Homo sapiens (Human) D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; serine family amino acid metabolic process [GO:0009069] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114] GALNAVRSLVPDALERKPK 1 5.6 0.86198 -0.082817 0 0 0 0 0 0 0 0 6.31439 0 0 0 Q9GZT5 WN10A_HUMAN Protein Wnt-10a WNT10A Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epidermis morphogenesis [GO:0048730]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; neural crest cell differentiation [GO:0014033]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; positive regulation of gene expression [GO:0010628]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; sebaceous gland development [GO:0048733]; skin development [GO:0043588]; tongue development [GO:0043586] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] FHWCCFVVCEECR;FSKDFLDSREPHR;LDSAGTVGR 3 8.4 0.98128 -1.704 0 0 0 0 0 8.77288 0 0 0 7.59805 0 0 Q9GZT8 NIF3L_HUMAN NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein) NIF3L1 ALS2CR1 MDS015 My018 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] GLGACTSRPIHPSK;INLNCTQK;ITWNTWKER;LTFTSQVR;LTFTSQVRCPIMILWMLLPKE 5 18.2 0.97326 -2.5674 0 0 0 0 9.66365 7.65155 0 0 0 11.4911 0 10.8582 Q9GZT9 EGLN1_HUMAN Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) EGLN1 C1orf12 PNAS-118 PNAS-137 Homo sapiens (Human) cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neuron apoptotic process [GO:0043523]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543] AGAREPR;CRSSFYCCK;EHQRQDWK;LALEYIVPCMNK;LLFFWSDR 5 10.3 0.97406 -2.4288 0 0 0 0 0 0 10.4488 12.6603 7.06641 8.54195 0 0 Q9GZU0 CF062_HUMAN Uncharacterized protein C6orf62 (HBV X-transactivated gene 12 protein) (HBV XAg-transactivated protein 12) C6orf62 XTP12 Nbla00237 Homo sapiens (Human) QFLHVLSRK 1 3.9 0.78272 0.030108 0 0 0 8.76597 0 0 0 0 0 0 0 0 Q9GZU1 MCLN1_HUMAN Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) MCOLN1 ML4 TRPML1 MSTP080 Homo sapiens (Human) adaptive immune response [GO:0002250]; autophagosome maturation [GO:0097352]; calcium ion export [GO:1901660]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to pH [GO:0071467]; iron ion transmembrane transport [GO:0034755]; monoatomic cation transport [GO:0006812]; phagosome maturation [GO:0090382]; positive regulation of lysosome organization [GO:1905673]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; transferrin transport [GO:0033572] cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; iron ion transmembrane transporter activity [GO:0005381]; ligand-gated calcium channel activity [GO:0099604]; lipid binding [GO:0008289]; monoatomic anion channel activity [GO:0005253]; monoatomic cation channel activity [GO:0005261]; NAADP-sensitive calcium-release channel activity [GO:0072345]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]" TAPAGPR 1 1.2 0.71026 0.15645 0 0 0 0 0 0 0 0 0 0 9.99718 0 Q9GZU2 PEG3_HUMAN Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) PEG3 KIAA0287 ZSCAN24 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] autophagosome [GO:0005776]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DLSLPVVAK;EMYQPEDDNNSDVTSDDDMTR;ESVIQQR;FECKDCGETFNK;GAIPFYECKDCGK 5 3.9 0.98067 -1.6618 0 0 9.08199 0 8.28563 6.44791 0 0 0 0 9.32134 0 Q9GZU2 PEG3_HUMAN Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) PEG3 KIAA0287 ZSCAN24 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] autophagosome [GO:0005776]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DLSLPVVAK;ESVIQQR;FECKDCGETFNK;GAIPFYECKDCGK;YQPEDDNNSDVTSDDDMTRNRR 5 4.3 0.95949 -1.0419 0 0 0 0 0 0 0 7.15472 0 0 0 0 Q9GZU3 TM39B_HUMAN Transmembrane protein 39B TMEM39B Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] EASQRGK;FIGSIVK 2 2.8 0.97981 -1.8584 8.60307 10.0769 0 0 0 0 0 7.6401 0 0 0 0 Q9GZU5 NYX_HUMAN Nyctalopin NYX CLRP Homo sapiens (Human) visual perception [GO:0007601] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] GVGGAGR;LFSVPERLLAELPALR 2 4.8 0.90316 -0.26691 0 0 0 0 0 0 0 10.9046 0 0 0 0 Q9GZU7 CTDS1_HUMAN Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1) CTDSP1 NIF3 NLIIF SCP1 Homo sapiens (Human) negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; protein dephosphorylation [GO:0006470]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] GILHSLFCCVCR 1 4.6 0.88099 -0.152 0 0 0 0 0 0 0 0 0 0 10.0289 0 Q9GZU8 PIP30_HUMAN PSME3-interacting protein (NEFA-interacting nuclear protein NIP30) (PA28G-interacting protein) PSME3IP1 C16orf94 FAM192A NIP30 PIP30 CDA018 CDA10 Homo sapiens (Human) negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein binding [GO:0032091] intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LLAGAVK;VGISQENKK;VGISQENKKEVEK 3 7.9 0.094946 0.37169 0 0 0 0 0 0 0 10.0961 11.0437 9.6923 0 0 Q9GZV1 ANKR2_HUMAN Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp) ANKRD2 ARPP Homo sapiens (Human) muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; euchromatin [GO:0000791]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; PML body [GO:0016605] protein kinase B binding [GO:0043422]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; structural constituent of muscle [GO:0008307] DREGDTALHDAVR;EIIDVGGIQNLIELR 2 7.8 0.87956 -0.15434 0 0 0 8.83305 0 0 0 0 8.02962 0 0 0 Q9GZV7 HPLN2_HUMAN Hyaluronan and proteoglycan link protein 2 (Brain link protein 1) HAPLN2 BRAL1 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; establishment of blood-nerve barrier [GO:0008065]; extracellular matrix assembly [GO:0085029]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; node of Ranvier [GO:0033268]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540] FPITTPRPR 1 2.6 0.90853 -0.31332 0 0 0 0 0 0 0 0 0 0 8.70318 0 Q9GZV8 PRD14_HUMAN PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14) PRDM14 Homo sapiens (Human) "cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]" intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; methyltransferase regulator activity [GO:0141107]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] EDDGCSCSICGK;MALPRPSEAVPQDK 2 4.6 0.95131 -0.66996 0 0 0 0 0 0 0 0 0 6.5208 0 6.27977 Q9GZX3 CHST6_HUMAN Carbohydrate sulfotransferase 6 (Corneal N-acetylglucosamine-6-O-sulfotransferase) (C-GlcNAc6ST) (hCGn6ST) (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta) (GST4-beta) (N-acetylglucosamine 6-O-sulfotransferase 5) (GlcNAc6ST-5) (Gn6st-5) CHST6 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517] DLVRSVFLCDMDVFDAYLPWRR;NLALDLVLPR 2 8.1 0.42578 0.19699 0 0 0 0 0 0 0 12.1564 0 0 7.16491 0 Q9GZX5 ZN350_HUMAN Zinc finger protein 350 (KRAB zinc finger protein ZFQR) (Zinc finger and BRCA1-interacting protein with a KRAB domain 1) (Zinc finger protein ZBRK1) ZNF350 ZBRK1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]" AFAYMSCLVKHKR;LQSESLVNR;SQFLLGQNHDIFDLRGKSLK 3 7.9 0.84052 -0.047429 0 0 0 0 14.4513 13.5571 0 5.2923 8.3682 0 0 0 Q9GZX9 TWSG1_HUMAN Twisted gastrulation protein homolog 1 TWSG1 TSG PSEC0250 Homo sapiens (Human) "BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; chondrocyte differentiation [GO:0002062]; forebrain development [GO:0030900]; hemopoiesis [GO:0030097]; mesoderm formation [GO:0001707]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytokine production [GO:0001818]; negative regulation of osteoblast differentiation [GO:0045668]; ossification [GO:0001503]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of BMP signaling pathway [GO:0030510]; salivary gland morphogenesis [GO:0007435]" extracellular space [GO:0005615] heparin binding [GO:0008201]; transforming growth factor beta binding [GO:0050431] ISCESMGASKYRWFHNACCECIGPECIDYGSK 1 14.3 0.61365 0.17447 0 0 0 0 0 0 6.95675 0 0 0 0 0 Q9GZY4 COA1_HUMAN Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa) COA1 C7orf44 MITRAC15 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] YAGSRRSMPLGAR 1 8.9 0.97137 -1.3496 0 0 0 0 0 10.1005 0 10.6354 0 10.1701 10.2086 11.4826 Q9GZZ1 NAA50_HUMAN N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit) NAA50 MAK3 NAT13 NAT5 Homo sapiens (Human) "establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634] histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; peptide-methionine-alpha-N-acetyltransferase activity [GO:0120518] KGSRIELGDVTPHNIK;RLYIMTLGCLAPYRR;VDHSQNQK 3 23.1 0.97057 -1.3346 0 0 11.2236 0 0 0 0 10.9575 9.02824 0 8.76291 0 Q9GZZ1 NAA50_HUMAN N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit) NAA50 MAK3 NAT13 NAT5 Homo sapiens (Human) "establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634] histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; peptide-methionine-alpha-N-acetyltransferase activity [GO:0120518] FYRKFGFEIIETK;KGSRIELGDVTPHNIK 2 35.8 0.95904 -1.0333 0 0 0 0 0 0 0 10.2148 0 0 0 0 Q9GZZ6 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to auditory stimulus [GO:0010996]; synaptic transmission, cholinergic [GO:0007271]" axon [GO:0030424]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] IPSSLVWRPDIVLYNK;VLGMPARR 2 5.3 0.81112 -0.014331 0 0 0 0 0 0 10.8216 0 8.17013 0 0 0 Q9GZZ7 GFRA4_HUMAN GDNF family receptor alpha-4 (GDNF receptor alpha-4) (GDNFR-alpha-4) (GFR-alpha-4) (Persephin receptor) GFRA4 Homo sapiens (Human) glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of ossification [GO:0030279]; nervous system development [GO:0007399]; ossification [GO:0001503] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167] CQRLRSEYVAQCLGR;SLLSILPVLALPALL 2 10 0.90746 -0.30615 0 3.35713 0 0 0 0 0 0 0 0 3.88947 0 Q9GZZ9 UBA5_HUMAN Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 Homo sapiens (Human) erythrocyte differentiation [GO:0030218]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of type II interferon production [GO:0032649]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270] LFFQPHQAGLSKVQAAEHTLR;LMALKRMGIVSDYEK 2 8.9 0.97539 -1.4402 0 0 0 0 9.20313 0 0 0 0 0 0 0 Q9H000 MKRN2_HUMAN E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) MKRN2 RNF62 HSPC070 Homo sapiens (Human) cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] LQVLHPFDPEQR 1 2.9 0.80746 0.012133 0 0 0 0 0 0 0 0 0 0 6.75128 0 Q9H013 ADA19_HUMAN Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) ADAM19 MLTNB FKSG34 Homo sapiens (Human) amyloid precursor protein catabolic process [GO:0042987]; membrane protein ectodomain proteolysis [GO:0006509]; placenta development [GO:0001890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; protein processing [GO:0016485] collagen-containing extracellular matrix [GO:0062023]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; SH3 domain binding [GO:0017124] DMNGEHRKCNMR;LIEIANYVDK;QFMLLVVWTELPEQKPR 3 4.1 0.9173 -0.41914 0 0 0 0 0 0 0 0 0 10.8909 8.41244 0 Q9H015 S22A4_HUMAN Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1) SLC22A4 ETT OCTN1 UT2H Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; symporter activity [GO:0015293] EVPHSCSRYR 1 1.8 0.98184 -1.5871 0 0 0 0 0 0 9.97671 0 0 0 0 0 Q9H019 MFR1L_HUMAN Mitochondrial fission regulator 1-like MTFR1L FAM54B HYST1888 MSTP116 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] AACSSSEEDDCVSLSK;LLALKKPALPALSR 2 10.3 0.64772 0.17131 0 0 0 0 0 5.55989 0 0 0 0 0 0 Q9H019 MFR1L_HUMAN Mitochondrial fission regulator 1-like MTFR1L FAM54B HYST1888 MSTP116 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] IVAADAVTSPR;LLALKKPALPALSR 2 12.2 0.91569 -0.431 0 0 0 7.20242 2.52153 0 9.68778 0 0 0 0 0 Q9H040 SPRTN_HUMAN DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan) SPRTN C1orf124 DVC1 UNQ1880/PRO4323 Homo sapiens (Human) DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; polyubiquitin modification-dependent protein binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130] ISVTVGNIPK;LSEPLLKLRPRK;VSFANQK 3 5.9 0.94465 -0.63733 0 0 0 0 8.01156 0 0 9.26108 9.29545 0 6.69613 0 Q9H069 DRC3_HUMAN Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) DRC3 LRRC48 Homo sapiens (Human) axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] NILRIDNLWQFENLR;NILRIDNLWQFENLRK;QEGILFKDVLSLQLDFR 3 7.2 0.93599 -0.52854 0 0 0 0 0 0 11.8685 9.33827 0 0 0 0 Q9H074 PAIP1_HUMAN Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) PAIP1 Homo sapiens (Human) "CRD-mediated mRNA stabilization [GO:0070934]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation by host of viral process [GO:0044794]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translation [GO:0019081]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002] RNA binding [GO:0003723]; translation activator activity [GO:0008494] APPSSQDKIPQQNSESAMAKPQVVVAPVLMSK 1 6.7 0.83644 -0.033673 0 0 0 0 0 0 0 0 6.05634 0 0 0 Q9H078 CLPB_HUMAN "Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form]" CLPB SKD3 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cellular response to heat [GO:0034605]; granulocyte differentiation [GO:0030851]; RIG-I signaling pathway [GO:0039529] cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein disaggregase activity [GO:0140545]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689] ALAPRLLLRLLR;EAEERRR;ELNFWAK;GAATGGR;GAATGGRQGGRFDTK;ITISKNFKENVIRPILK;LLSEGADVNAK;WLGLPAGVLITREDDFNNRLNNR 8 13 0.96751 -1.317 12.0955 11.6954 0 0 0 0 0 9.48057 5.74368 10.8369 9.23156 0 Q9H081 MIS12_HUMAN Protein MIS12 homolog MIS12 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070] cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] CKETPYSEEDFQHLQK 1 7.8 0.91662 -0.43023 0 0 0 0 8.40909 0 0 0 0 0 0 0 Q9H089 LSG1_HUMAN Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-) LSG1 Homo sapiens (Human) nuclear export [GO:0051168]; protein transport [GO:0015031]; ribosomal subunit export from nucleus [GO:0000054] Cajal body [GO:0015030]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EEDCSQDWKESSTADSEAR 1 2.9 0.92163 -0.43933 7.03331 0 0 0 0 0 0 0 0 0 0 0 Q9H091 ZMY15_HUMAN Zinc finger MYND domain-containing protein 15 ZMYND15 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872] CRQLEAQIRR;KPGRGAR 2 2.3 0.97293 -2.5946 0 13.134 0 0 0 0 0 0 0 0 0 0 Q9H093 NUAK2_HUMAN NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) NUAK2 OMPHK2 SNARK Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; negative regulation of apoptotic process [GO:0043066]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of hippo signaling [GO:0035330] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HRYEFLETLGKGTYGK 1 2.5 0.44276 0.19412 0 0 0 0 0 0 0 8.21437 0 0 0 0 Q9H094 NBPF3_HUMAN NBPF family member NBPF3 (Neuroblastoma breakpoint family member 3) (Protein AE2) (Protein SHIIIa4) NBPF3 L7 Homo sapiens (Human) cytoplasm [GO:0005737] GPVSPRSSGR;VQELYAPR;VQELYAPREVQKAEEK 3 4.2 0.973 -2.5301 0 0 0 0 0 0 0 0 10.5657 11.2711 0 0 Q9H095 DRC9_HUMAN Dynein regulatory complex protein 9 (IQ domain-containing protein G) IQCG DRC9 Homo sapiens (Human) cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]; spermatid development [GO:0007286] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; manchette [GO:0002177]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] calmodulin binding [GO:0005516]; Hsp70 protein binding [GO:0030544] ELQDSATYNSLLQALSKERENK;KVKQDLLELK;QIISLQKQLINVKK;TNTELQIAQTQK 4 13.1 0.9741 -1.4231 11.4862 0 0 11.0346 9.28297 8.47958 0 0 0 4.91409 5.44616 0 Q9H098 F107B_HUMAN Protein FAM107B FAM107B C10orf45 Homo sapiens (Human) ELLMNQKR 1 6.1 0.92691 -0.45509 0 0 0 0 0 9.41272 0 0 0 9.18869 0 0 Q9H0A0 NAT10_HUMAN RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) NAT10 ALP KIAA1709 Homo sapiens (Human) negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of translation [GO:0045727]; protein acetylation [GO:0006473]; regulation of centrosome duplication [GO:0010824]; regulation of translation [GO:0006417]; ribosomal small subunit biogenesis [GO:0042274]; rRNA acetylation involved in maturation of SSU-rRNA [GO:1904812]; rRNA modification [GO:0000154]; tRNA acetylation [GO:0051391] "chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; telomerase holoenzyme complex [GO:0005697]" ATP binding [GO:0005524]; DNA polymerase binding [GO:0070182]; mRNA N-acetyltransferase activity [GO:0106162]; N-acetyltransferase activity [GO:0008080]; RNA binding [GO:0003723]; rRNA cytidine N-acetyltransferase activity [GO:1990883]; tRNA binding [GO:0000049]; tRNA N-acetyltransferase activity [GO:0051392] FIEGISEK;ILIENGVAER;SLFVVVGDR;SVDQLEK 4 3.3 0.98061 -1.6468 17.2707 0 17.1745 0 0 0 11.331 0 10.1933 0 0 0 Q9H0A8 COMD4_HUMAN COMM domain-containing protein 4 COMMD4 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] LAGVGWR 1 3.5 0.93542 -0.52885 0 0 0 0 8.58459 0 0 0 0 0 0 0 Q9H0A9 SPC1L_HUMAN Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein) SPATC1L C21orf56 Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; sperm head-tail coupling apparatus [GO:0120212] identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237] LVIDVVPPK;RILAYVFPGVTR 2 6.2 0.95892 -1.0087 0 0 0 0 0 0 0 0 9.21609 0 0 0 Q9H0B3 IQCN_HUMAN IQ domain-containing protein N IQCN KIAA1683 Homo sapiens (Human) spermatid development [GO:0007286] mitochondrion [GO:0005739]; nucleus [GO:0005634] AASKSTGSGVTK;AEEGDIPYHAPQQVRFQHPEENR;IVQATWR;LLSPPIMVNK 4 3.8 0.97271 -2.7387 0 0 0 0 0 0 0 0 12.4812 0 9.51655 7.0456 Q9H0B6 KLC2_HUMAN Kinesin light chain 2 (KLC 2) KLC2 Homo sapiens (Human) lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinesin I complex [GO:0016938]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; kinesin binding [GO:0019894] EAEPLCK;QALEDLEK;QHLLFMSQIRK;RDSAPYGEYGSWYK;YEVAVPLCK 5 7.9 0.73512 0.11062 0 0 0 0 0 0 0 9.83845 0 0 0 0 Q9H0B6 KLC2_HUMAN Kinesin light chain 2 (KLC 2) KLC2 Homo sapiens (Human) lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinesin I complex [GO:0016938]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; kinesin binding [GO:0019894] EAEPLCK;QALEDLEK;RDSAPYGEYGSWYK;SLEAIELGLGEAQEEK;YEVAVPLCK 5 9.9 0.91563 -0.37613 0 0 0 0 0 0 7.87467 0 8.24322 0 0 0 Q9H0B8 CRLD2_HUMAN Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2) CRISPLD2 CRISP11 LCRISP2 UNQ2914/PRO1156/PRO9783 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; lung development [GO:0030324] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; transport vesicle [GO:0030133] glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201] EEILMLHNK;GSTCNRYQCPAGCLNHK;MTVWGEVWENAVYFVCNYSPK 3 9.5 0.95524 -0.83017 3.24784 0 0 0 0 5.91569 4.16832 0 0 10.0119 6.09324 0 Q9H0C2 ADT4_HUMAN "ADP/ATP translocase 4 (ADP,ATP carrier protein 4) (Adenine nucleotide translocator 4) (ANT 4) (Solute carrier family 25 member 31) (Sperm flagellar energy carrier protein)" SLC25A31 AAC4 ANT4 SFEC Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; regulation of mitochondrial membrane permeability [GO:0046902]; spermatogenesis [GO:0007283] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP:ADP antiporter activity [GO:0005471] DLLAGGVAAAVSKTAVAPIER;GLGDCIMK;GMVDCLVRIPR;GNLANVIR;TAVAPIER;YFPTQALNFAFK;YKQLFMSGVNKEK 7 23.2 0.98121 -2.0292 8.16727 0 0 10.5389 3.06459 5.91416 11.8343 0 0 0 0 4.95912 Q9H0C3 TM117_HUMAN Transmembrane protein 117 TMEM117 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] LFGQLLRLKMFR 1 2.3 0.86922 -0.094361 0 0 0 0 0 8.74527 0 0 0 0 0 0 Q9H0C5 BTBD1_HUMAN BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) BTBD1 C15orf1 NS5ATP8 Homo sapiens (Human) muscle organ development [GO:0007517]; neurogenesis [GO:0022008]; protein ubiquitination [GO:0016567]; regulation of protein binding [GO:0043393] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; protein-containing complex [GO:0032991] cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802] FAFLFNSELLSDVRFVLGKGR 1 4.4 0.53007 0.18665 0 0 0 0 0 6.52979 0 0 0 0 0 0 Q9H0C8 ILKAP_HUMAN Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16) ILKAP Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AGGNVRDGR 1 2.3 0.97698 -1.4949 0 0 0 0 0 0 0 0 9.57809 0 0 0 Q9H0D2 ZN541_HUMAN Zinc finger protein 541 ZNF541 Homo sapiens (Human) cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AGGLPADASPLFRQLFLK;KTTPGVPR;NLPGCPK;TEEKVPCSPRERPSHHPTPK 4 3.9 0.96525 -1.1573 0 0 0 0 0 10.6394 0 0 9.74583 0 8.78346 9.84599 Q9H0D6 XRN2_HUMAN 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) XRN2 Homo sapiens (Human) hippocampus development [GO:0021766]; mRNA processing [GO:0006397]; neuron differentiation [GO:0030182]; nuclear-transcribed mRNA catabolic process [GO:0000956]; retina development in camera-type eye [GO:0060041]; RNA catabolic process [GO:0006401]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369] aggresome [GO:0016235]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; 5'-3' exonuclease activity [GO:0008409]; 5'-3' RNA exonuclease activity [GO:0004534]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147] AALEEVYPDLTPEETRR;DQPAFTPSGILTPHALGSR;LWEAGWKQR;MVAIFEYIDRLFSIVRPRR;TLGHVMPR 5 8.2 0.97777 -1.5159 12.3851 0 0 9.76439 0 0 11.5166 0 0 0 0 0 Q9H0E2 TOLIP_HUMAN Toll-interacting protein TOLLIP Homo sapiens (Human) autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580] "interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]" ITPTQQQR 1 2.9 0.91335 -0.39033 0 8.26035 0 0 0 0 0 0 9.49223 0 0 0 Q9H0E3 SP130_HUMAN Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) SAP130 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459] nuclear speck [GO:0016607]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] AAYHHFQRYSDVR;AAYHHFQRYSDVRVK;LTNLQEGIIPKK 3 2.6 0.98063 -1.6363 0 0 4.99544 0 0 0 0 0 2.37746 3.19028 0 6.48301 Q9H0E7 UBP44_HUMAN Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) USP44 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of cell cycle process [GO:0010564]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulatory T cell differentiation [GO:0045066] chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; zinc ion binding [GO:0008270] IFRTWFEQSPIGR;LAMDTCK;LDLNQWLAMTASEKTR;SQNYHCTTRSGR 4 6.7 0.97517 -3.3083 0 0 0 0 0 10.8281 0 0 0 0 7.63263 0 Q9H0E9 BRD8_HUMAN Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) BRD8 SMAP SMAP2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular response to thyroid hormone stimulus [GO:0097067]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] mitochondrion [GO:0005739]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966] ATPPPSPLLSELLKK 1 1.6 0.59861 0.17837 0 0 0 0 0 0 0 0 9.98755 0 0 0 Q9H0F5 RNF38_HUMAN E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38) RNF38 Homo sapiens (Human) male gonad development [GO:0008584]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VICERVR 1 1.4 0.89894 -0.25725 12.9795 0 0 0 0 0 0 0 0 0 0 0 Q9H0F7 ARL6_HUMAN ADP-ribosylation factor-like protein 6 (Bardet-Biedl syndrome 3 protein) ARL6 BBS3 Homo sapiens (Human) cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; protein localization to cilium [GO:0061512]; protein polymerization [GO:0051258]; protein targeting to membrane [GO:0006612]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055] axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] DAVTSVK;LSVLLGLKKK 2 9.1 0.91689 -0.41935 0 0 0 0 0 2.42683 0 0 0 7.93705 0 0 Q9H0G5 NSRP1_HUMAN Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) NSRP1 CCDC55 NSRP70 Homo sapiens (Human) "developmental process [GO:0032502]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EAFVTSAYK;LTEEGQEK;SKAKEEHMK;VIETPENDFK;YSQREQERDR 5 8.2 0.9759 -4.5668 0 0 0 0 0 0 0 0 0 0 0 11.4029 Q9H0H0 INT2_HUMAN Integrator complex subunit 2 (Int2) INTS2 KIAA1287 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DSSYKNGSR;EKPSGWSQICKDSSYKNGSR;RETSSSVLWQMRR;TWFGTFIR;VSESNGEFFFK 5 4.3 0.97545 -3.3525 0 0 0 0 0 10.1431 10.4312 0 10.2944 8.17547 10.0067 0 Q9H0H3 KLH25_HUMAN Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) KLHL25 ENC2 Homo sapiens (Human) "negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of fatty acid oxidation [GO:0046321]; protein ubiquitination [GO:0016567]; regulation of translational initiation [GO:0006446]; ubiquitin-dependent protein catabolic process [GO:0006511]" Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AECPQPWR;LYEFSWRMCLVHFETVR 2 4.2 0.9418 -0.59388 0 0 0 0 0 0 0 0 0 0 10.7426 0 Q9H0H5 RGAP1_HUMAN Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP Homo sapiens (Human) actomyosin contractile ring assembly [GO:0000915]; erythrocyte differentiation [GO:0030218]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; monoatomic ion transport [GO:0006811]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; sulfate transmembrane transport [GO:1902358] acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233] "alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]" SALDVKLKHAR 1 1.7 0.98025 -1.5505 0 0 0 0 0 0 13.9595 0 0 0 0 0 Q9H0H9 C4F30_HUMAN Putative cytochrome P450 family member 4F30 CYP4F30P C2orf14 Homo sapiens (Human) VTPAGCLGGR 1 8.5 0.93624 -0.55224 0 0 0 0 0 0 0 9.21138 0 0 0 0 Q9H0I2 ENKD1_HUMAN Enkurin domain-containing protein 1 ENKD1 C16orf48 UNQ6410/PRO21183 Homo sapiens (Human) establishment of mitotic spindle orientation [GO:0000132]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515] 9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]; spindle pole [GO:0000922] alpha-tubulin binding [GO:0043014]; microtubule binding [GO:0008017] KLVQVEEAIKIFSRPK;LVQVEEAIK 2 4.6 0.87676 -0.12431 6.93511 11.7804 7.56247 11.503 0 0 0 14.2609 0 0 8.38007 13.6614 Q9H0I3 CF263_HUMAN Cilia- and flagella-associated protein 263 CFAP263 CCDC113 HSPC065 Homo sapiens (Human) cilium assembly [GO:0060271] axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991] EVADMKDDLR;ISAADYAQFR;KAWNRMK;KVEIAEMSLK;LKNVSLKVQR;SIRMWER 6 14.3 0.97473 -3.7382 0 0 0 0 0 14.8411 7.31949 9.48969 7.8375 0 0 10.6444 Q9H0J4 QRIC2_HUMAN Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) cell projection assembly [GO:0030031]; flagellated sperm motility [GO:0030317]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; sperm flagellum [GO:0036126] LLTEMDAR;SDSDRHRSR;VTVADIEK 3 1.7 0.95188 -0.71072 0 0 0 0 0 0 0 0 0 8.80168 0 0 Q9H0J9 PAR12_HUMAN Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) protein auto-ADP-ribosylation [GO:0070213] nucleus [GO:0005634] metal ion binding [GO:0046872]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723] FLRAGKNCR;NLVYGTTK 2 2.4 0.98079 -1.7482 0 13.1939 0 0 0 0 0 0 0 0 0 0 Q9H0K1 SIK2_HUMAN Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) SIK2 KIAA0781 QIK SNF1LK2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HRITKTEVAIK;SHRSSFPVEQR 2 2.4 0.94237 -0.61596 0 0 0 0 0 10.3269 0 0 0 11.3061 0 7.17961 Q9H0K6 PUS7L_HUMAN Pseudouridylate synthase PUS7L (EC 5.4.99.-) (Pseudouridylate synthase 7 homolog-like protein) PUS7L Homo sapiens (Human) mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; pseudouridine synthesis [GO:0001522] nucleus [GO:0005634] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] ISEIQLEPNNFPK;KAITYQAMVVRK;VGQWYHDILSRDGLQTCRFK;VTPERLK 4 7.4 0.97857 -1.9221 0 0 0 9.31719 7.49793 7.04691 0 7.79889 8.10407 0 0 0 Q9H0M0 WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) WWP1 Homo sapiens (Human) central nervous system development [GO:0007417]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] GGPQIAYERGFR;LLFAIEETEGFGQE;RRLYVIFR;RRVYYVDHNTR;SRQPDGCMDPVR;VGKDTWLPR;YFVDHNTR 7 8 0.97416 -3.7932 8.08162 0 0 0 8.89257 0 11.8367 8.74517 0 8.43229 9.40299 0 Q9H0M4 ZCPW1_HUMAN Zinc finger CW-type PWWP domain protein 1 ZCWPW1 Homo sapiens (Human) cell differentiation [GO:0030154]; homologous chromosome pairing at meiosis [GO:0007129]; meiosis I [GO:0007127]; positive regulation of DNA recombination [GO:0045911]; positive regulation of double-strand break repair [GO:2000781]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; nucleus [GO:0005634] histone reader activity [GO:0140566]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] EAHEKVEKTQGGHEHR;TKPRGLGGDAGTADGR 2 4.9 0.84562 -0.059856 0 0 7.84549 0 9.53251 0 0 0 0 0 0 0 Q9H0M5 ZN700_HUMAN Zinc finger protein 700 ZNF700 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFRCCNSLR;FSSFQIHERKHR;THMGEKPYECKDCGKAFS;TQERDHTGEKPYACKVCGK 4 7.8 0.9729 -2.769 0 0 12.6721 9.32744 0 9.33548 0 0 8.55229 0 0 0 Q9H0P0 5NT3A_HUMAN Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36) NT5C3A NT5C3 P5N1 UMPH1 HSPC233 Homo sapiens (Human) defense response to virus [GO:0051607]; nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside metabolic process [GO:0006213] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; tRNA 2'-phosphotransferase activity [GO:0000215]; XMP 5'-nucleosidase activity [GO:0106411] EIVAESDVMLK 1 3.3 0.8979 -0.23168 0 0 0 0 0 0 0 0 0 9.92166 0 0 Q9H0Q0 CYRIA_HUMAN CYFIP-related Rac1 interactor A (Protein CYRIA) CYRIA FAM49A Homo sapiens (Human) regulation of actin filament polymerization [GO:0030833] membrane [GO:0016020] small GTPase binding [GO:0031267] FTTKHLNDESTSK;VMLETPEYR 2 6.8 0.95141 -0.70517 0 11.8711 0 0 0 0 0 0 0 0 0 0 Q9H0Q3 FXYD6_HUMAN FXYD domain-containing ion transport regulator 6 (Phosphohippolin) FXYD6 UNQ521/PRO1056 Homo sapiens (Human) positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] sodium channel regulator activity [GO:0017080] IGGLVFAVVLFSVGILLILSRRCK 1 25.3 0.62484 0.1736 0 0 0 7.63481 0 0 0 0 0 0 0 0 Q9H0R1 AP5M1_HUMAN AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) AP5M1 C14orf108 MUDENG Homo sapiens (Human) endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020] TGTYKGKPQVSISITEK 1 3.5 0.88237 -0.17593 7.42752 5.88682 0 0 0 0 0 0 0 0 0 0 Q9H0R5 GBP3_HUMAN Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) GBP3 Homo sapiens (Human) cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; positive regulation of pyroptotic inflammatory response [GO:0140639] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; protein homodimerization activity [GO:0042803] EIEVECVK 1 1.3 0.89931 -0.25808 0 0 0 0 0 0 0 12.0879 0 0 0 0 Q9H0R6 GATA_HUMAN "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1)" QRSL1 Homo sapiens (Human) glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of protein stability [GO:0031647] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] EVSAALK;LASVSLKQ;NPWSYSKQYR 3 4.7 0.97689 -2.2154 0 0 0 9.85368 10.6951 0 0 0 0 0 9.52174 9.82008 Q9H0S4 DDX47_HUMAN Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) DDX47 Homo sapiens (Human) extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LFALVLTPTR;SILLATDVASR;VIPRDRK 3 6.2 0.95648 -0.99318 0 0 0 0 0 0 0 0 0 0 0 7.46761 Q9H0T7 RAB17_HUMAN Ras-related protein Rab-17 RAB17 Homo sapiens (Human) anterograde dendritic transport [GO:0098937]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; establishment of melanosome localization [GO:0032401]; filopodium assembly [GO:0046847]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; regulation of dendrite development [GO:0050773]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; transcytosis [GO:0045056] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; melanosome [GO:0042470]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVTFQEGK;GPARQAK;LVLLGSGSVGKSSLALRYVK;VFKLVLLGSGSVGK;YVKNDFK 5 19.8 0.97657 -2.2475 6.44647 0 0 0 0 0 0 7.76752 2.81371 0 0 10.7469 Q9H0V1 TM168_HUMAN Transmembrane protein 168 TMEM168 Homo sapiens (Human) regulation of ubiquitin-dependent protein catabolic process [GO:2000058] nuclear membrane [GO:0031965]; transport vesicle [GO:0030133] sodium channel regulator activity [GO:0017080] LSVVFAGMIELTFFILSAFK;TVKAVYGVSK 2 4.3 0.90596 -0.27167 0 8.52771 0 0 0 9.68827 0 0 0 0 0 0 Q9H0V9 LMA2L_HUMAN VIP36-like protein (Lectin mannose-binding 2-like) (LMAN2-like protein) LMAN2L VIPL PSEC0028 UNQ368/PRO704 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein folding [GO:0006457]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] D-mannose binding [GO:0005537]; metal ion binding [GO:0046872] DRMQPGPVFGNMDK;QGALWNRVPCFLR;WQEQSRK 3 9.8 0.95547 -0.8531 0 0 10.3009 0 8.36632 0 9.56392 0 0 0 8.4079 0 Q9H0W5 CCDC8_HUMAN Coiled-coil domain-containing protein 8 CCDC8 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; regulation of mitotic nuclear division [GO:0007088] 3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] INWASFR;LAGGVWR;TVRFQTPGR 3 4.3 0.97575 -2.3215 0 0 12.0558 8.5552 0 0 0 0 0 0 0 0 Q9H0W7 THAP2_HUMAN THAP domain-containing protein 2 THAP2 Homo sapiens (Human) nucleolus [GO:0005730]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FPLDPKRR;ILEQDQQDK 2 7.5 0.96151 -1.071 0 0 0 11.2369 11.0576 10.7065 14.2059 14.3091 14.4105 0 0 13.6614 Q9H0W9 CK054_HUMAN Ester hydrolase C11orf54 (EC 3.1.-.-) C11orf54 LP4947 PTD012 Homo sapiens (Human) extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]" IAEVGGVPYLLPLVNQK;IDQPKETHSIGR;RTGPLNFVTCMR;VIEVKAK 4 15.2 0.93375 -0.51047 12.1338 0 0 7.28235 0 7.31895 0 0 0 9.30086 0 0 Q9H0X4 F234A_HUMAN Protein FAM234A (Protein ITFG3) FAM234A C16orf9 ITFG3 Homo sapiens (Human) cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GSWTGQSSRR 1 1.9 0.90739 -0.30348 0 0 0 0 0 0 0 0 0 11.4725 0 0 Q9H0X9 OSBL5_HUMAN Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) OSBPL5 KIAA1534 OBPH1 ORP5 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol binding [GO:0032934] ETLKAQKENYR;QESLMPWKPQLFHLDPITQEWHYR;RFSLCPPSSTPQK 3 5.5 0.96682 -1.2674 0 0 0 0 0 0 0 6.79064 12.478 0 0 0 Q9H0Y0 ATG10_HUMAN Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like) ATG10 APG10L PP12616 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; ER overload response [GO:0006983]; mitophagy [GO:0000423]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031] cytosol [GO:0005829] Atg12 conjugating enzyme activity [GO:0061651]; Atg12 transferase activity [GO:0019777] DCSDGYMCK 1 7.2 0.91267 -0.32248 0 0 3.97993 0 0 0 0 0 0 0 0 0 Q9H106 SIRPD_HUMAN Signal-regulatory protein delta (SIRP-delta) (Protein tyrosine phosphatase non-receptor type substrate 1-like 2) SIRPD PTPNS1L2 Homo sapiens (Human) extracellular region [GO:0005576]; plasma membrane [GO:0005886] LIYNFKQGNFPR;LIYNFKQGNFPRVK 2 7.1 0.9785 -2.0606 0 0 0 0 0 0 0 0 0 0 10.8862 0 Q9H114 CSTL1_HUMAN Cystatin-like 1 (RCET11) CSTL1 Homo sapiens (Human) signaling receptor ligand precursor processing [GO:0140448] extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type peptidase activity [GO:0008234] LGHFQRWEGFQQK 1 9 0.92149 -0.44314 0 0 0 0 0 0 0 11.2776 0 0 0 0 Q9H115 SNAB_HUMAN Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) NAPB SNAPB Homo sapiens (Human) "intracellular protein transport [GO:0006886]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]" extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044] soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905] EREAVQLMAEAEK 1 4.4 0.88192 -0.17966 0 0 0 9.21369 0 0 0 10.4925 0 0 0 0 Q9H116 GZF1_HUMAN GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) GZF1 ZBTB23 ZNF336 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" DVKRHVLQVHEGGGER;EVVKPPYPK 2 3.5 0.94035 -0.58381 0 0 0 0 0 0 0 11.0616 9.90399 0 0 0 Q9H156 SLIK2_HUMAN SLIT and NTRK-like protein 2 SLITRK2 CXorf2 KIAA1854 SLITL1 UNQ9197/PRO34756 Homo sapiens (Human) axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; synaptic membrane adhesion [GO:0099560] dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] EIKPLTFDALINLQLLFLNNNLLR 1 2.8 0.70958 0.15634 0 0 0 0 0 0 10.2108 0 0 0 0 0 Q9H158 PCDC1_HUMAN Protocadherin alpha-C1 (PCDH-alpha-C1) PCDHAC1 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVLPTDAVKQR 1 1.1 0.88867 -0.18765 0 0 0 0 0 0 0 0 0 5.69922 0 0 Q9H159 CAD19_HUMAN Cadherin-19 CDH19 CDH7L2 UNQ478/PRO941 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AVEPESEFVIK 1 1.4 0.094136 0.37487 0 0 0 0 0 0 0 0 0 0 10.1635 0 Q9H165 BC11A_HUMAN B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) BCL11A CTIP1 EVI9 KIAA1809 ZNF856 Homo sapiens (Human) cellular response to L-glutamate [GO:1905232]; negative regulation of axon extension [GO:0030517]; negative regulation of branching morphogenesis of a nerve [GO:2000173]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron projection development [GO:0010977]; negative regulation of neuron remodeling [GO:1904800]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; postsynapse [GO:0098794]; SWI/SNF complex [GO:0016514] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription regulatory region nucleic acid binding [GO:0001067]" DEPSSYTCTTCK;GCSPGESASGGLSKK;RSDTCEYCGK;RSDTCEYCGKVFK;VLNNDIKTE 5 5.9 0.96479 -1.2202 0 0 7.02004 0 0 0 0 0 0 8.41545 8.71277 0 Q9H165 BC11A_HUMAN B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) BCL11A CTIP1 EVI9 KIAA1809 ZNF856 Homo sapiens (Human) cellular response to L-glutamate [GO:1905232]; negative regulation of axon extension [GO:0030517]; negative regulation of branching morphogenesis of a nerve [GO:2000173]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron projection development [GO:0010977]; negative regulation of neuron remodeling [GO:1904800]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; postsynapse [GO:0098794]; SWI/SNF complex [GO:0016514] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription regulatory region nucleic acid binding [GO:0001067]" DEPSSYTCTTCK;ELKMCGSFR 2 8.6 0.90273 -0.2633 0 0 7.34855 0 0 0 0 0 0 0 0 0 Q9H169 STMN4_HUMAN Stathmin-4 (Stathmin-like protein B3) (RB3) STMN4 Homo sapiens (Human) microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005] tubulin binding [GO:0015631] AIEENNNFIKMAK;LQEKDKHAEEVR;YQEAELLKHLAEK 3 20.1 0.97912 -1.9006 0 0 0 0 6.86728 0 0 7.84493 0 0 0 0 Q9H172 ABCG4_HUMAN ATP-binding cassette sub-family G member 4 (EC 7.6.2.-) ABCG4 WHITE2 Homo sapiens (Human) cellular response to high density lipoprotein particle stimulus [GO:0071403]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; regulation of DNA-templated transcription [GO:0006355]; transmembrane transport [GO:0055085] cytoplasmic vesicle [GO:0031410]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] ABC-type sterol transporter activity [GO:0034041]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] MRDLELREVK;TLLKCLSGKFCR 2 3.8 0.97454 -2.386 12.3427 0 0 0 0 0 0 0 10.036 0 0 0 Q9H173 SIL1_HUMAN Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) SIL1 UNQ545/PRO836 Homo sapiens (Human) cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] EGAEMESSK 1 2 0.91061 -0.3191 0 0 0 0 0 0 0 0 0 0 7.92023 0 Q9H175 CSRN2_HUMAN Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) CSRNP2 C12orf22 FAM130A1 TAIP12 Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; phosphatase binding [GO:0019902]; sequence-specific DNA binding [GO:0043565]" EECGCDCR;LSREECGCDCR 2 2 0.95557 -0.83642 6.66974 0 0 0 0 0 0 0 0 6.78215 0 0 Q9H190 SDCB2_HUMAN Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2) SDCBP2 SITAC18 Homo sapiens (Human) cell population proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; nervous system development [GO:0007399] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" NGLLTNHYVCEVDGQNVIGLK;VAPVTGYSLGVR 2 15.9 0.57933 0.18087 0 0 0 0 7.05929 0 0 0 0 8.75439 0 0 Q9H195 MUC3B_HUMAN Mucin-3B (MUC-3B) (Intestinal mucin-3B) MUC3B Homo sapiens (Human) Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] AEATRTALSNSPHSR;ALVGGLTAGAALLVLLLLALGVR;ALVGGLTAGAALLVLLLLALGVRAVR;FTSSITTTK;RAAPTGYEEFYFPLVEATR;TTSHSTPSFTSPIATR 6 1 0.94192 -0.59631 0 0 0 0 0 9.95546 0 3.83188 0 10.394 10.6825 0 Q9H1B4 NXF5_HUMAN Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1) NXF5 TAPL1 Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658] cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleus [GO:0005634] RNA binding [GO:0003723] WFKVTIPYGIKYDK 1 3.5 0.76574 0.060082 0 0 0 0 0 0 0 0 0 0 0 9.35279 Q9H1B5 XYLT2_HUMAN Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II) XYLT2 XT2 UNQ3058/PRO9878 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] extracellular space [GO:0005615]; Golgi membrane [GO:0000139] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158] DALSALARASTK;FLVLPLTFNRKLPLR;VTNWNRK 3 3.9 0.97878 -1.9666 0 4.80447 0 0 0 0 0 0 0 0 0 0 Q9H1B7 I2BPL_HUMAN Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) IRF2BPL C14orf4 EAP1 KIAA1865 My039 Homo sapiens (Human) development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567] extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LLGDLLPEAVR;SAAQVSSSRR;YLEYEKK 3 3.5 0.97448 -1.3931 0 0 0 0 8.93517 0 0 0 0 0 0 0 Q9H1C0 LPAR5_HUMAN Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93) LPAR5 GPR92 GPR93 Homo sapiens (Human) behavioral response to pain [GO:0048266] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] KTVRLLLANLVIFLLCFVPYNSTLAVYGLLR;LVAASVPAR;YRDLEVRLCFESFSDELWK 3 15.9 0.93819 -0.57697 0 0 0 4.73281 7.93976 0 0 0 0 0 0 0 Q9H1C3 GL8D2_HUMAN Glycosyltransferase 8 domain-containing protein 2 (EC 2.4.1.-) GLT8D2 GALA4A UNQ1901/PRO4347 Homo sapiens (Human) Golgi apparatus [GO:0005794]; membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] ALLRKINQVLLFLLIVTLCVILYK;INQVLLFLLIVTLCVILYKK 2 7.2 0.74828 0.083988 0 0 0 0 0 0 0 0 4.35685 0 4.35184 0 Q9H1C4 UN93B_HUMAN Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1) UNC93B1 UNC93 UNC93B Homo sapiens (Human) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell morphogenesis [GO:0000902]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; T cell antigen processing and presentation [GO:0002457]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosome [GO:0005764] Toll-like receptor binding [GO:0035325] AKLAVLLVTLVAAAVSYLR 1 3.2 0.91947 -0.43838 0 0 0 0 0 6.234 0 0 0 0 0 0 Q9H1D0 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) TRPV6 ECAC2 Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; parathyroid hormone secretion [GO:0035898]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to calcium ion [GO:0051592] calcium channel complex [GO:0034704]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LSPVRVWPRPQAPKEPALHPMGLSLPK 1 3.5 0.6945 0.16215 0 0 8.18582 0 0 0 0 0 0 0 0 0 Q9H1D9 RPC6_HUMAN DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) POLR3F Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; double-stranded DNA binding [GO:0003690]" AVAINRLLSMGQLDLLR;DIRYKSNLPLTEINK 2 10.1 0.86977 -0.094908 0 0 0 0 0 7.72574 11.8398 0 0 0 0 0 Q9H1E1 RNAS7_HUMAN Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2) RNASE7 UNQ2516/PRO6006 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytolysis in another organism [GO:0051715]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; peptidoglycan binding [GO:0042834]; RNA nuclease activity [GO:0004540] IQHMQPSPQACNSAMKNINK;LTSGKHPNCR 2 19.2 0.98083 -1.6045 0 9.4301 0 0 0 0 9.65898 0 0 0 0 0 Q9H1E3 NUCKS_HUMAN Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) NUCKS1 NUCKS JC7 Homo sapiens (Human) cellular response to X-ray [GO:0071481]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; gene conversion [GO:0035822]; interstrand cross-link repair [GO:0036297]; intracellular glucose homeostasis [GO:0001678]; modulation by host of RNA binding by virus [GO:1990968]; modulation by host of viral genome replication [GO:0044827]; modulation by host of viral RNA-binding transcription factor activity [GO:1990969]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of insulin receptor signaling pathway [GO:0046626]; replication fork processing [GO:0031297] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] ATVTPSPVK;DDSHSAEDSEDEK;DSGSDEDFLMEDDDDSDYGSSK;EEDEEPESPPEK;SGDEGSEDEAPSGED;VGRPTASK 6 32.5 0.00883 1.1186 0 6.50535 5.88894 6.99729 6.74524 0 6.26138 9.1172 5.0106 9.6919 9.74394 6.13586 Q9H1H9 KI13A_HUMAN Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) KIF13A RBKIN Homo sapiens (Human) cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; plus-end-directed vesicle transport along microtubule [GO:0072383]; regulation of cytokinesis [GO:0032465]; vesicle cargo loading [GO:0035459]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DDEDGDDMDSYQEEDLNCVR;ELTVTWEEKLR;EQLSQAEAMKAPELK;GLVKDKIIVVPLK;KTEEIAQER;LIKELTVTWEEKLR;RREYLDEQIK;TEKTEDDVER;VEVSYMEIYNEKVR;VSNKTEK 10 6 0.97578 -2.3324 0 4.42901 8.18249 0 9.01039 10.3953 0 8.36855 9.96939 0 0 0 Q9H1I8 ASCC2_HUMAN Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) ASCC2 ASC1P100 RQT3 Homo sapiens (Human) DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130] EANKATRANHNR;LSHSRKK;SKGMIPS;TAYILQAVESAWEGVDR 4 5.7 0.97523 -3.3012 0 0 0 9.96415 0 0 0 0 0 0 0 0 Q9H1J5 WNT8A_HUMAN Protein Wnt-8a (Protein Wnt-8d) WNT8A WNT8D Homo sapiens (Human) anterior/posterior axis specification [GO:0009948]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; dorsal/ventral axis specification [GO:0009950]; neural crest cell fate commitment [GO:0014034]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; secondary palate development [GO:0062009] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] ALMNLHNNRAGR;NCSMGDFENCGCDGSNNGK 2 8.8 0.642 0.17196 0 0 0 0 0 0 0 0 0 2.6311 0 0 Q9H1J7 WNT5B_HUMAN Protein Wnt-5b WNT5B Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; muscle cell differentiation [GO:0042692]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052] endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102] DWLWGGCGDNVEYGYRFAK;EGELSTCGCSR;FAKEFVDAR;TGIKECQHQFRQR;TSEGMDGCELMCCGR 5 17.8 0.97569 -2.3217 11.7801 0 11.8379 0 0 7.67122 0 0 0 8.87292 0 7.44419 Q9H1K0 RBNS5_HUMAN Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) RBSN ZFYVE20 Homo sapiens (Human) early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] phosphatidylinositol-3-phosphate binding [GO:0032266]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] AYIFDAK;LLKREGDDR;QAEEEDLQR;TLQENLR 4 4.1 0.97776 -2.1647 0 0 0 0 7.98567 5.2109 0 0 0 0 0 0 Q9H1K1 ISCU_HUMAN Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) ISCU NIFUN Homo sapiens (Human) "[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of iron ion import across plasma membrane [GO:1904439]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron ion binding [GO:0005506]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]" AAAGAFR;ELCLPPVK 2 9 0.93368 -0.51092 0 0 0 0 0 0 0 0 0 0 0 9.85102 Q9H1K4 GHC2_HUMAN Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) SLC25A18 GC2 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313] LAANDFFRRLLMEDGMQR;LQNQHGK 2 7.9 0.58058 0.17991 0 0 0 7.53714 0 0 0 0 0 0 0 0 Q9H1K6 TLRN1_HUMAN Talin rod domain-containing protein 1 (Mesoderm development candidate 1) TLNRD1 MESDC1 Homo sapiens (Human) stress fiber [GO:0001725] actin binding [GO:0003779]; identical protein binding [GO:0042802] EVKVAPSELAR;EVKVAPSELARSR;LVSVCDHCKGK;VAPSELARSR 4 6.6 0.97785 -1.5255 0 0 0 6.73769 0 0 10.6898 11.42 0 0 0 0 Q9H1M4 DB127_HUMAN "Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127)" DEFB127 C20orf73 DEFB27 UNQ1956/PRO6071 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular region [GO:0005576] CWNNYVQGHCRK 1 12.1 0.67497 0.16621 0 0 0 0 6.72588 0 0 0 0 0 0 0 Q9H1P3 OSBL2_HUMAN Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2) OSBPL2 KIAA0772 ORP2 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle priming [GO:0010807] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; presynaptic active zone cytoplasmic component [GO:0098831] "cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sterol transfer activity [GO:0120015]" TSLPAPMFSRSDFSVWTILK 1 4.2 0.66821 0.16863 0 0 15.3252 14.1831 0 13.5319 0 15.0037 0 13.3472 0 14.2294 Q9H1R2 DUS15_HUMAN Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) DUSP15 C20orf57 VHY Homo sapiens (Human) dephosphorylation [GO:0016311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of oligodendrocyte differentiation [GO:0048713]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" HFKECINFIHCCR;YQICLCFGEEDPGPTQHPK 2 10.8 0.86782 -0.09167 0 0 0 10.2621 9.99308 0 0 0 9.83777 0 0 0 Q9H1R3 MYLK2_HUMAN "Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)" MYLK2 Homo sapiens (Human) cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; neuromuscular synaptic transmission [GO:0007274]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of gene expression [GO:0010628]; protein autophosphorylation [GO:0046777]; regulation of muscle filament sliding [GO:0032971]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle satellite cell differentiation [GO:0014816]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; nucleus [GO:0005634]; sarcomere [GO:0030017]; synapse [GO:0045202] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; myosin light chain binding [GO:0032027]; myosin light chain kinase activity [GO:0004687] ISSSGALMALGV 1 2 0.91042 -0.29943 0 0 0 0 0 0 0 0 0 0 0 10.88 Q9H1U4 MEGF9_HUMAN Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) MEGF9 EGFL5 KIAA0818 UNQ671/PRO1305 Homo sapiens (Human) regulation of actin filament polymerization [GO:0030833] basement membrane [GO:0005604]; cytoplasm [GO:0005737]; membrane [GO:0016020] small GTPase binding [GO:0031267] GNHCEECK 1 1.3 0.91483 -0.39033 0 0 0 0 0 0 0 0 0 7.11593 0 0 Q9H1U9 S2551_HUMAN Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51) SLC25A51 MCART1 Homo sapiens (Human) aerobic electron transport chain [GO:0019646]; mitochondrial NAD transmembrane transport [GO:1990549] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] NAD transmembrane transporter activity [GO:0051724] CHGIGEYYRGLVPILFRNGLSNVLFFGLR 1 9.8 0.95587 -0.98227 0 0 0 0 0 0 10.7136 0 0 0 0 0 Q9H1V8 S6A17_HUMAN Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) SLC6A17 NTT4 Homo sapiens (Human) alanine transport [GO:0032328]; brain development [GO:0007420]; glycine transport [GO:0015816]; L-leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104] cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] symporter activity [GO:0015293] HFHLLSDGSNTLSVSYKK;LDKMLDPQVWR 2 4 0.9008 -0.26004 0 4.50278 0 0 0 8.62311 0 0 0 0 0 0 Q9H1X1 RSPH9_HUMAN Radial spoke head protein 9 homolog RSPH9 C6orf206 MRPS18AL1 Homo sapiens (Human) axonemal central apparatus assembly [GO:1904158]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458]; radial spoke assembly [GO:0062177] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; kinocilium [GO:0060091]; motile cilium [GO:0031514]; radial spoke head [GO:0001535]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]; sperm flagellum [GO:0036126] NMDLPFML 1 2.9 0.93675 -0.54709 0 10.9897 0 0 0 0 0 0 0 0 0 0 Q9H1X3 DJC25_HUMAN DnaJ homolog subfamily C member 25 DNAJC25 Homo sapiens (Human) protein folding [GO:0006457] endoplasmic reticulum membrane [GO:0005789] ELWIKENYEVYK;LANDPRWK 2 5.6 0.98063 -1.7244 0 0 0 0 0 0 0 5.64189 0 0 0 0 Q9H1Z8 AUGN_HUMAN Augurin (Esophageal cancer-related gene 4 protein) (ECRG4) ECRG4 C2orf40 UNQ761/PRO1508 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular senescence [GO:0090398]; central nervous system development [GO:0007417]; G1 to G0 transition [GO:0070314]; regulation of cell population proliferation [GO:0042127] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] HYDEDSAIGPR;VAVDENK 2 12.2 0.93343 -0.50031 0 5.96855 11.697 0 0 0 0 0 0 0 0 0 Q9H201 EPN3_HUMAN Epsin-3 (EPS-15-interacting protein 3) EPN3 Homo sapiens (Human) endocytosis [GO:0006897] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] clathrin binding [GO:0030276]; EH domain binding [GO:1990175]; phospholipid binding [GO:0005543] EEAEKPVPPASHRDEDLQLQLALR;QERTHALKTK 2 5.4 0.87645 -0.13312 0 0 0 0 0 0 0 0 0 0 7.04625 10.6956 Q9H211 CDT1_HUMAN DNA replication factor Cdt1 (Double parked homolog) (DUP) CDT1 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly [GO:0071163]; mitotic cell cycle [GO:0000278]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated DNA replication [GO:2000104]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated DNA replication [GO:2000105]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of nuclear cell cycle DNA replication [GO:0033262]; response to sorbitol [GO:0072708] kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182] AADLAHITAR;LTTAQEVLAR 2 3.7 0.94114 -0.61385 0 6.47226 0 0 0 0 0 0 10.2275 0 0 0 Q9H221 ABCG8_HUMAN ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) ABCG8 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328] apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982] DLDDFLWK;EKAQSLAALFLEK 2 3.1 0.93299 -0.4954 0 0 0 0 0 0 0 10.0366 0 0 8.22608 0 Q9H222 ABCG5_HUMAN ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1) ABCG5 Homo sapiens (Human) cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to ionizing radiation [GO:0010212]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328] apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982] LAVITRLLQNLIMGLFLLFFVLR;SAICHKTLK;TLKNIERMK 3 5.8 0.97225 -1.3607 0 0 0 0 0 0 8.73863 0 6.05634 0 0 0 Q9H223 EHD4_HUMAN EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) EHD4 HCA10 HCA11 PAST4 FKSG7 Homo sapiens (Human) cellular response to growth factor stimulus [GO:0071363]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; pinocytosis [GO:0006907]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676] DIQSLPQKAAVRK 1 2.4 0.9671 -1.3104 0 0 0 0 0 0 0 0 0 0 9.71876 0 Q9H227 GBA3_HUMAN Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase-like protein 1) (Cytosolic galactosylceramidase) (EC 3.2.1.46) (Cytosolic glucosylceramidase) (EC 3.2.1.45) (Cytosolic glycosylceramidase) (Cytosolic GCase) (Glucosidase beta acid 3) (Glucosylceramidase beta 3) (Klotho-related protein) (KLrP) GBA3 CBG CBGL1 Homo sapiens (Human) beta-glucoside catabolic process [GO:1901805]; galactosylceramide catabolic process [GO:0006683]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; glycosylceramide catabolic process [GO:0046477]; oligosaccharide catabolic process [GO:0009313]; positive regulation of exo-alpha-sialidase activity [GO:1903017]; protein stabilization [GO:0050821] catalytic complex [GO:1902494]; cytosol [GO:0005829]; membrane [GO:0016020] beta-galactosidase activity [GO:0004565]; beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042] GIDYYNK;LIKYQENK;LLPDGTTGFINQK;LPEFTEEEKK;VPYTSAK;YAQFCFSTFGDR 6 12.2 0.97368 -2.9854 0 0 10.0591 0 0 7.10811 0 0 0 0 0 0 Q9H237 PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.250) (Protein MG61) PORCN MG61 PORC PPN Homo sapiens (Human) glycoprotein metabolic process [GO:0009100]; lipid modification [GO:0030258]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055] AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020] palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147] LLWRLGLPSYLK 1 2.6 0.88806 -0.18882 0 0 0 0 0 0 0 7.44766 0 0 0 0 Q9H239 MMP28_HUMAN Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin) MMP28 MMP25 UNQ1893/PRO4339 Homo sapiens (Human) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of macrophage chemotaxis [GO:0010760]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ALQLLLWGHLDAQPAERGGQELRK;WYKQHLSYR 2 6.3 0.91744 -0.35345 0 0 0 0 0 0 0 10.9556 8.31737 0 0 0 Q9H244 P2Y12_HUMAN P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) P2RY12 HORK3 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; cell projection organization [GO:0030030]; cellular response to ATP [GO:0071318]; cerebral cortex radial glia-guided migration [GO:0021801]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; lamellipodium assembly [GO:0030032]; monoatomic ion transport [GO:0006811]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of chemotaxis [GO:0050921]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of ruffle assembly [GO:1900029]; regulation of chemotaxis [GO:0050920]; regulation of microglial cell migration [GO:1904139]; response to axon injury [GO:0048678]; substrate-dependent cell migration, cell extension [GO:0006930]; visual system development [GO:0150063]" cell body membrane [GO:0044298]; cell projection membrane [GO:0031253]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; guanyl-nucleotide exchange factor activity [GO:0005085] VFIIIAVFFICFVPFHFAR 1 5.6 0.60954 0.17579 0 0 0 0 0 0 0 9.69136 0 0 0 0 Q9H251 CAD23_HUMAN Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DHYILTALAK;DNPENPR;ILSGAEGK;VGNATIDR;VIQMIDENK 5 1.3 0.97878 -1.9034 0 0 0 8.16274 0 0 9.47699 7.2241 0 0 11.6906 0 Q9H251 CAD23_HUMAN Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DLSNQGRR 1 1.5 0.84053 -0.043952 0 0 8.99896 0 0 0 0 0 0 0 0 0 Q9H252 KCNH6_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-gated potassium channel subunit Kv11.2) KCNH6 ERG2 Homo sapiens (Human) membrane repolarization during cardiac muscle cell action potential [GO:0086013]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] HRNSSPR;SLSQRLLSQSFLGSEGSHGRPGGPGPGTGR 2 3.9 0.90774 -0.30576 9.33994 0 0 0 0 0 8.63981 0 0 0 0 0 Q9H254 SPTN4_HUMAN "Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)" SPTBN4 KIAA1642 SPTBN3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult walking behavior [GO:0007628]; axonogenesis [GO:0007409]; cardiac conduction [GO:0061337]; central nervous system projection neuron axonogenesis [GO:0021952]; clustering of voltage-gated sodium channels [GO:0045162]; fertilization [GO:0009566]; negative regulation of heart rate [GO:0010459]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of sodium ion transport [GO:0002028]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]; vesicle-mediated transport [GO:0016192] actin filament [GO:0005884]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; cell body fiber [GO:0070852]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear matrix [GO:0016363]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein-membrane anchor activity [GO:0106006]; phosphatase binding [GO:0019902]; phospholipid binding [GO:0005543]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] AELEASR;DALLLWCQMK;DGLAFNALIHRHRPDLVDFSK;ELDANRK;ELQGQIEEK;ESWLNENQR;FFGDPTELAAK 7 2.9 0.9798 -1.876 0 0 10.8266 0 0 8.65055 7.71438 5.17509 0 9.62079 0 0 Q9H257 CARD9_HUMAN Caspase recruitment domain-containing protein 9 (hCARD9) CARD9 Homo sapiens (Human) antifungal innate immune response [GO:0061760]; apoptotic signaling pathway [GO:0097190]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immunoglobulin mediated immune response [GO:0016064]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776]; regulation of interleukin-2 production [GO:0032663]; response to aldosterone [GO:1904044]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]; response to xenobiotic stimulus [GO:0009410]; stress-activated MAPK cascade [GO:0051403] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591] ALLQARVQELEASVQEGKLDR;KVGVLLDILQRTGHK;VGVLLDILQR 3 6.7 0.97295 -2.5058 0 0 0 0 8.64616 0 0 0 0 6.42186 10.0836 0 Q9H267 VP33B_HUMAN Vacuolar protein sorting-associated protein 33B (hVPS33B) VPS33B Homo sapiens (Human) collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192] clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023] protein-containing complex binding [GO:0044877] KYKVIFSPQK 1 1.6 0.97791 -1.5242 0 0 0 0 0 0 0 0 0 0 0 8.44497 Q9H269 VPS16_HUMAN Vacuolar protein sorting-associated protein 16 homolog (hVPS16) VPS16 Homo sapiens (Human) "autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]" autophagosome [GO:0005776]; axon [GO:0030424]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; presynapse [GO:0098793]; recycling endosome [GO:0055037] actin binding [GO:0003779]; actin filament binding [GO:0051015] ILAHWACYKVQQK;KYELYSMDWDLK;RMPEVPGLQSAPSCWTVLCQDR 3 5.6 0.81396 -0.0068004 0 10.2566 0 0 0 0 8.0105 11.575 0 0 0 0 Q9H270 VPS11_HUMAN Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein ubiquitination [GO:0016567]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vacuole organization [GO:0007033]; vesicle docking involved in exocytosis [GO:0006904] autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] DSQSSDKQILNIYDLCNK;ILMHHIPEQTTQLLK;LHAEAISLLKSGR;LTLLTDPPTARLTSSLEAGLQR;VLRQAGYYSHALYLAENHAHHEWYLK 5 10 0.96109 -1.0627 0 0 0 0 7.90707 0 10.0608 0 0 0 10.3606 10.9839 Q9H295 DCSTP_HUMAN Dendritic cell-specific transmembrane protein (DC-STAMP) (hDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (IL-four-induced protein) (FIND) (Transmembrane 7 superfamily member 4) DCSTAMP TM7SF4 Homo sapiens (Human) cellular response to interleukin-4 [GO:0071353]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; membrane fusion [GO:0061025]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell growth [GO:0030308]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of bone resorption [GO:0045780]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of monocyte differentiation [GO:0045657] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] ILVSASFYPSVER;LSLYLTKIHFWLPVLK 2 6.2 0.8139 -0.0063475 0 0 0 8.13288 0 0 0 0 0 0 0 6.0392 Q9H299 SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1) SH3BGRL3 P1725 Homo sapiens (Human) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; ruffle membrane [GO:0032587] SQQSEVTR;VYSTSVTGSR;VYSTSVTGSREIKSQQSEVTR 3 22.6 0.9555 -0.94324 11.8363 0 3.95903 0 0 0 0 0 0 11.0337 7.69808 0 Q9H2A2 AL8A1_HUMAN 2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase 12) (Aldehyde dehydrogenase family 8 member A1) ALDH8A1 ALDH12 Homo sapiens (Human) 9-cis-retinoic acid biosynthetic process [GO:0042904]; L-kynurenine catabolic process [GO:0097053]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573] cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminomuconate-semialdehyde dehydrogenase activity [GO:0047102]; retinal dehydrogenase activity [GO:0001758] SIYSEFLK 1 1.6 0.93335 -0.51439 0 0 0 0 0 0 0 0 12.3856 0 0 0 Q9H2A3 NGN2_HUMAN Neurogenin-2 (NGN-2) (Class A basic helix-loop-helix protein 8) (bHLHa8) (Protein atonal homolog 4) NEUROG2 ATOH4 BHLHA8 NGN2 Homo sapiens (Human) axon development [GO:0061564]; forebrain development [GO:0030900]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" GAKTAETVQR 1 3.7 0.92082 -0.44651 0 0 0 0 0 0 0 0 0 0 0 9.06969 Q9H2A9 CHST8_HUMAN Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) CHST8 Homo sapiens (Human) carbohydrate biosynthetic process [GO:0016051]; central nervous system development [GO:0007417]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] Golgi membrane [GO:0000139]; membrane [GO:0016020] N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146] LSTYTKMLFVREPFER;TYDFYYMDYLMFNYSKPFADLY;VLYCEVPK 3 10.8 0.91746 -0.42121 7.07028 0 0 11.5851 11.3265 10.8415 0 0 0 12.5503 10.3456 0 Q9H2C0 GAN_HUMAN Gigaxonin (Kelch-like protein 16) GAN GAN1 KLHL16 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DDGSTYK;FCDAHLVLDGEEIPVQKNILAAASPYIRTK;KIGCYAAMK;LNVGNER;LNYNPPK 5 10.1 0.98103 -1.7376 11.4653 11.5901 11.7397 0 0 0 11.8451 11.2525 11.3999 10.7912 10.7073 11.0246 Q9H2C2 ARV1_HUMAN Protein ARV1 (hARV1) ARV1 HT035 Homo sapiens (Human) bile acid metabolic process [GO:0008206]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; intracellular sterol transport [GO:0032366]; regulation of cholesterol metabolic process [GO:0090181]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] sterol transfer activity [GO:0120015] LCIFCLLCEAYLR;YAKEWDFYR 2 8.1 0.9641 -1.1152 0 0 0 0 6.37884 0 0 0 0 0 0 0 Q9H2C5 O52A5_HUMAN Olfactory receptor 52A5 (Odorant receptor HOR3'beta5) (Olfactory receptor OR11-33) OR52A5 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAILIIPSLGLIK;TKQIRDHIVK 2 7.3 0.9796 -1.5451 0 0 8.56499 0 0 0 0 0 14.2299 0 0 0 Q9H2C8 O51V1_HUMAN Olfactory receptor 51V1 (Odorant receptor HOR3'beta1) (Olfactory receptor 51A12) (Olfactory receptor OR11-36) OR51V1 OR51A12 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IIKIGLTIIGR 1 3.4 0.88815 -0.19005 0 0 0 0 0 0 4.31121 0 0 0 0 0 Q9H2D6 TARA_HUMAN TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) TRIOBP KIAA1662 TARA HRIHFB2122 Homo sapiens (Human) actin modification [GO:0030047]; auditory receptor cell stereocilium organization [GO:0060088]; barbed-end actin filament capping [GO:0051016]; cell division [GO:0051301]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; sensory perception of sound [GO:0007605] "actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; midbody [GO:0030496]; nucleus [GO:0005634]; stereocilium base [GO:0120044]" actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] DLAQRSEER;EVQCLRDELQMMQKDK;LAKQEELER;LSEEIEK;SEAAGAFQAQDEGR;SQAEPPHPWSPEKRPEGDR;STLTQASSMTPHSGPR;TIQRDNPR;TSCAQRDDPRASSPNR;TSCAQRDNLR 10 5.2 0.68492 0.16262 0 0 0 0 0 0 5.64322 0 0 0 0 0 Q9H2D6 TARA_HUMAN TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) TRIOBP KIAA1662 TARA HRIHFB2122 Homo sapiens (Human) actin modification [GO:0030047]; auditory receptor cell stereocilium organization [GO:0060088]; barbed-end actin filament capping [GO:0051016]; cell division [GO:0051301]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; sensory perception of sound [GO:0007605] "actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; midbody [GO:0030496]; nucleus [GO:0005634]; stereocilium base [GO:0120044]" actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] DLAQRSEER;EVQCLRDELQMMQKDK;LAKQEELER;LFGQERRTMLPAK;LSEEIEK;QADSPDLLNFK;SQAEPPHPWSPEKRPEGDR;STLTQASSMTPHSGPR;TIQRDNPR;TSCAQRDDPRASSPNR;TSCAQRDNLR 11 5.9 0.9753 -3.18 6.73971 6.99808 0 0 0 8.42978 10.1854 0 0 8.97528 8.82645 9.41475 Q9H2E6 SEM6A_HUMAN Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) SEMA6A KIAA1368 SEMAQ Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytoskeleton organization [GO:0007010]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion involved in sprouting angiogenesis [GO:0106089]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of neuron migration [GO:2001224]; semaphorin-plexin signaling pathway [GO:0071526] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] EKELTHSRR;SLGESPTLR 2 1.7 0.93374 -0.49746 2.85467 0 0 0 0 0 0 0 0 3.72748 0 0 Q9H2F3 3BHS7_HUMAN "3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181)" HSD3B7 Homo sapiens (Human) B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity [GO:0047016]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LGELRVFDQHLGPWLEELK 1 5.1 0.81086 -0.014509 0 10.2826 0 0 0 0 0 0 0 0 0 0 Q9H2F5 EPC1_HUMAN Enhancer of polycomb homolog 1 EPC1 Homo sapiens (Human) "DNA-templated transcription [GO:0006351]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]" cytoplasm [GO:0005737]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463]; enzyme-substrate adaptor activity [GO:0140767] AVTILEMIK;EVYEYWIK;HQEAMDVKEFK;VGRGGRVLLDR 4 4.7 0.97068 -1.3373 0 0 0 0 0 7.25295 0 0 8.30104 0 9.15616 0 Q9H2F9 CCD68_HUMAN Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1) CCDC68 Homo sapiens (Human) microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; cytoplasm [GO:0005737] DLQLLEMNK;EKVNILEAQNK;HSQITELENLVQR;LKQHVENLNQVAEKLEEK;QHVENLNQVAEKLEEK;SSATYGK 6 17.3 0.976 -4.5053 0 0 10.7051 8.57278 8.08156 9.64926 11.4265 0 8.95489 0 0 0 Q9H2G2 SLK_HUMAN STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) SLK KIAA0204 STK2 Homo sapiens (Human) apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DQYFMQR;EVINEVEK;HQLLKRHEK;KKEVINEVEK;LGEDDKTQK;NERMAQHQK 6 3.6 0.97831 -6.5181 0 0 0 0 6.62227 0 0 0 0 11.7389 0 0 Q9H2H8 PPIL3_HUMAN Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) PPIL3 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] YTVFGKVIDGLETLDELEKLPVNEK 1 15.5 0.66842 0.16893 0 0 0 0 0 0 0 5.82441 0 0 0 0 Q9H2H9 S38A1_HUMAN Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) SLC38A1 ATA1 NAT2 SAT1 SNAT1 Homo sapiens (Human) "amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; female pregnancy [GO:0007565]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamine metabolic process [GO:0006541]; glutamine transport [GO:0006868]; L-alpha-amino acid transmembrane transport [GO:1902475]; neurotransmitter uptake [GO:0001504]; neutral amino acid transport [GO:0015804]; positive regulation of L-glutamine import across plasma membrane [GO:1901036]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; transport across blood-brain barrier [GO:0150104]" axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]; L-amino acid transmembrane transporter activity [GO:0015179]; L-glutamine transmembrane transporter activity [GO:0015186]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] LAVIVAVILTVPVLFFTVR;SLTNSHLEK 2 5.7 0.91608 -0.34885 0 0 0 0 7.6585 10.2643 0 0 0 0 0 0 Q9H2I8 LRMDA_HUMAN Leucine-rich melanocyte differentiation-associated protein LRMDA C10orf11 CDA017 Homo sapiens (Human) melanocyte differentiation [GO:0030318] FIRDDQL 1 3.5 0.96647 -1.2716 0 0 0 0 11.1833 11.1661 0 0 0 0 0 0 Q9H2J7 S6A15_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) SLC6A15 B0AT2 NTT73 SBAT1 Homo sapiens (Human) amino acid transport [GO:0006865]; L-leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725] membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; branched-chain amino acid:sodium symporter activity [GO:0015657]; neurotransmitter transmembrane transporter activity [GO:0005326]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] ANVINEKCITQNSETIMKFLK 1 2.9 0.5288 0.18665 0 0 11.1111 0 0 0 0 0 0 0 6.30985 0 Q9H2K0 IF3M_HUMAN "Translation initiation factor IF-3, mitochondrial (IF-3(Mt)) (IF-3Mt) (IF3(mt)) (IF3mt)" MTIF3 DC38 Homo sapiens (Human) mitochondrial translational initiation [GO:0070124]; ribosome disassembly [GO:0032790] mitochondrion [GO:0005739] "ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" VIHLFDEKGNDLGNMHR 1 6.1 0.81235 -0.012544 9.33805 0 0 0 0 0 0 0 0 0 0 0 Q9H2K2 TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL Homo sapiens (Human) "negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; Wnt signaling pathway [GO:0016055]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]" enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779] LCTVQSVNCR;SCYICHRQLLFCRVTLGK 2 2.4 0.84377 -0.053349 0 0 0 0 0 7.21053 0 0 0 9.13927 0 0 Q9H2K8 TAOK3_HUMAN Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) TAOK3 DPK JIK KDS MAP3K18 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of JNK cascade [GO:0046329]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase inhibitor activity [GO:0004860]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transferase activity [GO:0016740] DLTTFLESQK;ELDNLQYRK;FVDYCLQK;LKAEMDEHRLK;LQHQTELENQLEYNK;MDLIRLQHQTELENQLEYNKR;TLKDEQTR 7 7.5 0.97099 -1.3457 0 11.184 0 0 4.00935 10.4119 0 0 0 0 7.90551 8.51068 Q9H2L5 RASF4_HUMAN Ras association domain-containing protein 4 RASSF4 AD037 Homo sapiens (Human) signal transduction [GO:0007165] ILHGPCEK;LQMQDDR;RPSCPLK;TYNCYHEGK 4 9.7 0.97239 -1.3663 0 6.43841 0 0 0 0 7.38526 6.86802 0 7.96376 0 0 Q9H2M3 BHMT2_HUMAN S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Homo sapiens (Human) L-methionine salvage [GO:0071267]; methylation [GO:0032259]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477] cytosol [GO:0005829]; extracellular exosome [GO:0070062] S-adenosylmethionine-homocysteine S-methyltransferase activity [GO:0008898]; S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270] LFRQQLEVFAWK 1 3.3 0.9237 -0.44772 0 0 11.5969 0 7.98442 0 7.42652 0 0 0 0 0 Q9H2M9 RBGPR_HUMAN Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3GAP2 KIAA0839 Homo sapiens (Human) establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087]; synaptic signaling [GO:0099536] autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991] enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] EEILSGALRRDPSK;ELLKLQALLEKYK;HIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSK;VEPATPLAVRFGLPDSRR 4 5.9 0.97839 -2.0994 8.26111 6.2299 0 0 0 0 8.99693 0 11.2043 0 0 7.56605 Q9H2P0 ADNP_HUMAN Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) ADNP ADNP1 KIAA0784 Homo sapiens (Human) cGMP-mediated signaling [GO:0019934]; estrous cycle [GO:0044849]; intracellular nitric oxide homeostasis [GO:0033484]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission [GO:0050805]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of synapse assembly [GO:0051965]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to carbohydrate [GO:0009743]; short-term memory [GO:0007614] axon [GO:0030424]; chromatin [GO:0000785]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; copper ion binding [GO:0005507]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; peptide binding [GO:0042277]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SLPSQQMVNR;SMGLPPR 2 1.5 0.84593 -0.059994 0 0 0 0 0 0 0 0 0 0 0 12.0521 Q9H2S1 KCNN2_HUMAN Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) KCNN2 Homo sapiens (Human) membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379] cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286] NTKLVKK 1 1.2 0.66861 0.16879 0 0 0 2.78165 0 0 0 0 0 0 0 7.40548 Q9H2S5 RNF39_HUMAN RING finger protein 39 (EC 2.3.2.27) (Protein HZFw) RNF39 HZFW Homo sapiens (Human) innate immune response [GO:0045087] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LLISADRR;VAFYDGR 2 3.6 0.96485 -1.1538 0 0 0 0 0 12.3974 0 0 0 0 0 0 Q9H2S5 RNF39_HUMAN RING finger protein 39 (EC 2.3.2.27) (Protein HZFw) RNF39 HZFW Homo sapiens (Human) innate immune response [GO:0045087] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KGCAPGPLGER;LLISADRR 2 5.4 0.73677 0.10861 0 0 0 0 0 0 0 0 0 7.72315 0 0 Q9H2S9 IKZF4_HUMAN Zinc finger protein Eos (Ikaros family zinc finger protein 4) IKZF4 KIAA1782 ZNFN1A4 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CPFCNYACRRR 1 1.9 0.27607 0.25521 0 0 9.8659 0 0 0 0 0 0 0 0 0 Q9H2U1 DHX36_HUMAN ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) DHX36 DDX36 KIAA1488 MLEL1 RHAU Homo sapiens (Human) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; negative regulation of translation [GO:0017148]; ossification [GO:0001503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of embryonic development [GO:0045995]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase III [GO:0006359]; response to exogenous dsRNA [GO:0043330]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; telomerase RNA stabilization [GO:0090669]" "axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; double-stranded RNA binding [GO:0003725]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; pre-miRNA binding [GO:0070883]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; telomerase RNA binding [GO:0070034]; transcription cis-regulatory region binding [GO:0000976]" ELRKELDILLQEK;IVCTQPR;LPVEPHIGK;LQSRLPR;VAKIRLNLGK 5 4.6 0.97319 -2.4961 0 0 0 0 0 8.34908 9.93698 10.3026 10.6292 7.85873 0 0 Q9H2U2 IPYR2_HUMAN "Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)" PPA2 HSPC124 Homo sapiens (Human) diphosphate metabolic process [GO:0071344]; phosphate-containing compound metabolic process [GO:0006796]; regulation of mitochondrial membrane potential [GO:0051881] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; protein serine/threonine phosphatase activity [GO:0004722] EPMNPIKQYVKDGK;IWENGIPMK;TGAPAAACLR 3 9.5 0.95528 -0.93459 0 0 0 0 0 0 0 7.95332 0 7.64378 0 0 Q9H2U9 ADAM7_HUMAN Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83) ADAM7 GP83 Homo sapiens (Human) epididymis development [GO:1905867]; epithelial cell morphogenesis [GO:0003382]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of sperm capacitation [GO:1902492]; proteolysis [GO:0006508] cell surface [GO:0009986]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222] AGSICRPAK;CSQNQYHQYLK;DTGHTHDDDILK;LNRKTLVLHLLR;YVELFIVADDTVYRR 5 7.8 0.98076 -1.6194 0 0 0 8.02403 0 0 0 10.3756 4.62749 0 0 0 Q9H2V7 SPNS1_HUMAN Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1) SPNS1 SPIN1 PP20300 Homo sapiens (Human) lysophospholipid transport [GO:0051977]; phospholipid efflux [GO:0033700]; regulation of lysosomal lumen pH [GO:0035751] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743] transmembrane transporter activity [GO:0022857] NLIFGLITCLTGVLGVGLGVEISRR;NWPPSFLSEFR;VTPGLGVVAVLLLFLVVREPPRGAVER 3 13.9 0.38462 0.21584 8.8568 0 0 0 6.48702 0 0 0 0 0 8.19486 0 Q9H2W1 M4A6A_HUMAN Membrane-spanning 4-domains subfamily A member 6A (CD20 antigen-like 3) (Four-span transmembrane protein 3) MS4A6A 4SPAN3 CD20L3 MS4A6 CDA01 MSTP090 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] VLLKLLEVYRK 1 4.3 0.77036 0.052868 0 0 0 3.65283 0 0 0 0 0 0 0 0 Q9H2W2 MIXL1_HUMAN Homeobox protein MIXL1 (Homeodomain protein MIX) (hMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein) MIXL1 MIXL Homo sapiens (Human) cell migration involved in gastrulation [GO:0042074]; digestive tract development [GO:0048565]; endoderm development [GO:0007492]; endoderm formation [GO:0001706]; endodermal cell differentiation [GO:0035987]; gastrulation [GO:0007369]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of mesoderm development [GO:2000382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" GAAAPSASQR 1 4.3 0.89623 -0.23628 0 0 0 0 0 0 0 0 0 0 0 10.592 Q9H2W6 RM46_HUMAN "Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial) (L46mt) (MRP-L46) (P2ECSL)" MRPL46 C15orf4 LIECG2 Homo sapiens (Human) mitochondrial translation [GO:0032543] cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] ALDENQRLAKK 1 3.9 0.95712 -0.99775 0 0 0 0 0 0 0 0 0 0 9.18115 0 Q9H2X0 CHRD_HUMAN Chordin CHRD UNQ217/PRO243 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; dorsal/ventral pattern formation [GO:0009953]; floor plate development [GO:0033504]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell adhesion [GO:0045785]; positive regulation of mesenchymal cell proliferation [GO:0002053]; skeletal system development [GO:0001501]; spinal cord dorsal/ventral patterning [GO:0021513] extracellular space [GO:0005615] BMP binding [GO:0036122]; cytokine binding [GO:0019955] CVLCACEAPQWGR;GGTGEVHCEK 2 2.4 0.96488 -1.2202 0 0 0 0 0 0 0 0 0 9.17585 0 0 Q9H2X6 HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) HIPK2 Homo sapiens (Human) "adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; gene expression [GO:0010467]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; lung morphogenesis [GO:0060425]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; respiratory system process [GO:0003016]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; thyroid gland development [GO:0030878]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RNA polymerase II transcription regulator complex [GO:0090575] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; virion binding [GO:0046790] QQPTSTTSSRK;TIIVPPLK;VIDFGSASHVSK 3 2.6 0.25573 0.26976 0 0 0 0 0 0 5.21715 0 0 5.17656 5.64264 0 Q9H2X9 S12A5_HUMAN Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) SLC12A5 KCC2 KIAA1176 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; dendritic spine development [GO:0060996]; hypotonic response [GO:0006971]; intracellular chloride ion homeostasis [GO:0030644]; intracellular pH reduction [GO:0051452]; learning [GO:0007612]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of postsynapse assembly [GO:0150052]; response to xenobiotic stimulus [GO:0009410]; thermosensory behavior [GO:0040040] cell periphery [GO:0071944]; dendrite membrane [GO:0032590]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634] ammonium channel activity [GO:0008519]; chloride transmembrane transporter activity [GO:0015108]; metal ion binding [GO:0046872]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] DLTTFLYHLR;EHEEAENNEGGKKKPVQAPR;SAFDPPNFPICLLGNRTLSR;SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLR 4 8.2 0.9739 -1.4093 0 8.90923 0 0 0 0 10.0395 0 10.297 0 0 0 Q9H2Y7 ZN106_HUMAN Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) ZNF106 SH3BP3 ZFP106 ZNF474 Homo sapiens (Human) insulin receptor signaling pathway [GO:0008286] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GPPQRDWK;NGLLLRTLEGHSKTILCMK;SKTGVHLPEPNLNSAR;SPLLPCPATKSLSQKQDPK;TSRELSTSPCNPIVR;VSGKNGSAAREKPR;YSHDRYNWQR 7 5.4 0.97511 -3.9681 0 0 0 9.54454 0 0 0 10.8394 5.82454 8.98524 0 10.3341 Q9H2Y9 SO5A1_HUMAN Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) SLCO5A1 OATP5A1 SLC21A15 Homo sapiens (Human) sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] sodium-independent organic anion transmembrane transporter activity [GO:0015347] GVIIVPSAGVGIVLGGYIIK;GVIIVPSAGVGIVLGGYIIKKLK 2 2.9 0.95555 -0.86813 4.91423 0 0 7.10203 0 0 0 0 0 0 0 9.00686 Q9H300 PARL_HUMAN "Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]" PARL PSARL PRO2207 Homo sapiens (Human) membrane protein proteolysis [GO:0033619]; mitochondrial fusion [GO:0008053]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of mitochondrion organization [GO:0010821]; regulation of mitophagy [GO:1901524]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of proteolysis [GO:0030162]; regulation of reactive oxygen species metabolic process [GO:2000377]; signal peptide processing [GO:0006465] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] VQSYFDGIK 1 2.4 0.90914 -0.3146 0 0 0 0 0 0 0 0 0 0 11.0361 0 Q9H310 RHBG_HUMAN Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) RHBG Homo sapiens (Human) ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; transepithelial ammonium transport [GO:0070634] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; spectrin-associated cytoskeleton [GO:0014731] ammonium channel activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379] VFVGFGFLMVFLQR 1 4.6 0.87791 -0.13672 0 0 0 10.0101 0 0 0 0 0 0 0 0 Q9H324 ATS10_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-) ADAMTS10 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CDSPTPGDGPEECK;GTGATAESRLFYK 2 2.4 0.91722 -0.42964 0 0 0 0 0 0 0 6.05257 0 5.78487 0 0 Q9H329 E41LB_HUMAN Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) EPB41L4B EHM2 LULU2 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060] apical part of cell [GO:0045177]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200] QELEREK;VSEKTLQTPLLPSPVADHVKCNILK;YARGAAGR 3 4.4 0.97317 -2.492 0 0 0 0 0 7.94953 0 0 0 0 0 0 Q9H329 E41LB_HUMAN Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) EPB41L4B EHM2 LULU2 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060] apical part of cell [GO:0045177]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200] NLGGMQSMMYR;YARGAAGR 2 3.7 0.89712 -0.23738 0 0 0 0 0 0 0 0 0 0 0 5.26517 Q9H330 TM245_HUMAN Transmembrane protein 245 (Protein CG-2) TMEM245 C9orf5 Homo sapiens (Human) membrane [GO:0016020] ADGGGPK;AVGPSGGGGETPR;GESAPTLSTSPSPSSPSPTSPSPTLGRR;IPVFLVIVFLMSVGTLYEK 4 7.6 0.89222 -0.2135 0 0 0 12.8207 0 0 0 0 0 10.6322 0 0 Q9H334 FOXP1_HUMAN Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) FOXP1 HSPC215 Homo sapiens (Human) cellular response to tumor necrosis factor [GO:0071356]; DNA damage response [GO:0006974]; endothelial cell activation [GO:0042118]; macrophage activation [GO:0042116]; monocyte activation [GO:0042117]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of defense response to bacterium [GO:1900424]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-12 production [GO:0032655]; regulation of macrophage colony-stimulating factor production [GO:1901256]; regulation of monocyte differentiation [GO:0045655]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor production [GO:0032680]; response to lipopolysaccharide [GO:0032496]; response to testosterone [GO:0033574]; striatum development [GO:0021756]; T follicular helper cell differentiation [GO:0061470] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HLFYHSATPASQKQPEPIYSK;QLTLNEIYNWFTRMFAYFR 2 6.6 0.8416 -0.042416 0 0 0 0 8.85907 0 0 0 0 0 10.2899 0 Q9H336 CRLD1_HUMAN Cysteine-rich secretory protein LCCL domain-containing 1 (CocoaCrisp) (Cysteine-rich secretory protein 10) (CRISP-10) (LCCL domain-containing cysteine-rich secretory protein 1) (Trypsin inhibitor Hl) CRISPLD1 CRISP10 LCRISP1 UNQ342/PRO541 Homo sapiens (Human) face morphogenesis [GO:0060325]; hematopoietic stem cell homeostasis [GO:0061484] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] YYPPREEETNEIER 1 2.8 0.83319 -0.028378 0 9.02826 0 0 0 0 0 0 0 0 0 0 Q9H339 O51B5_HUMAN Olfactory receptor 51B5 (Odorant receptor HOR5'beta5) (Olfactory receptor OR11-37) OR51B5 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LACADTTFNR;LYPAVLVVFIFVLDYLIIFISYVLILK 2 11.9 0.86607 -0.088247 0 0 0 0 0 0 0 7.14547 9.79601 0 0 0 Q9H340 O51B6_HUMAN Olfactory receptor 51B6 (Odorant receptor HOR5'beta6) OR51B6 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SPLRYTSILTNTQVMK;TKQIQSGILR 2 8.3 0.98047 -1.801 0 0 0 8.6376 0 0 0 0 0 0 0 0 Q9H342 O51J1_HUMAN Olfactory receptor 51J1 (Odorant receptor HOR5'beta8) (Olfactory receptor 51J2) OR51J1 OR51J1P OR51J2 Homo sapiens (Human) sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EIHGAIVRMLLEKR 1 4.4 0.96504 -1.15 0 0 0 0 0 0 9.56642 0 0 0 0 0 Q9H361 PABP3_HUMAN Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) PABPC3 PABP3 PABPL3 Homo sapiens (Human) mRNA metabolic process [GO:0016071] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] AVNSATGVPTV;AVTEMNGR;FSPAGPILSIR;IVATKPLYVALAQR;KEERQAYLTNEYMQR;NLDDGIDDER 6 10.9 0.45314 0.19145 0 0 0 0 0 0 0 7.89184 0 0 0 0 Q9H3C7 GGNB2_HUMAN Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) GGNBP2 LCRG1 LZK1 ZNF403 Homo sapiens (Human) cell differentiation [GO:0030154]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634] LEQLCEEFSEEER;LEQLCEEFSEEERVR;LGSCITDPGNR 3 3.7 0.94663 -0.65782 0 0 4.01641 0 3.35036 3.498 0 3.09253 0 0 0 9.8996 Q9H3E2 SNX25_HUMAN Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801] endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol binding [GO:0035091] ADLLRARNMK;DEAGEEAVDDGTNQINEQASFAVNKLR;DVQSLSLRIMLAEILTTK;EHFGMYMERMDK;LSHVDVVKVVCNDVVRTLLTHFCDLK;SIDQKFMEK 6 12.1 0.98136 -1.7048 0 0 0 0 10.0419 10.4359 10.7249 11.3308 9.61362 0 0 0 Q9H3G5 CPVL_HUMAN "Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)" CPVL VLP PSEC0124 UNQ197/PRO223 Homo sapiens (Human) proteolysis [GO:0006508] extracellular exosome [GO:0070062] serine-type carboxypeptidase activity [GO:0004185] YVPAIAHLIHSLNPVR 1 3.4 0.78308 0.026449 0 0 0 0.750692 0 0 4.20484 0 0 0 0 0 Q9H3H9 TCAL2_HUMAN Transcription elongation factor A protein-like 2 (TCEA-like protein 2) (Transcription elongation factor S-II protein-like 2) TCEAL2 My048 MY0876G0 Homo sapiens (Human) nucleus [GO:0005634] LENEGNTENTGKR 1 5.7 0.64051 0.17203 0 0 0 10.545 8.75832 0 0 0 0 0 0 0 Q9H3K2 GHITM_HUMAN Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5) GHITM DERP2 MICS1 TMBIM5 My021 UNQ244/PRO281 Homo sapiens (Human) apoptotic process [GO:0006915]; calcium export from the mitochondrion [GO:0099093]; calcium ion transport [GO:0006816]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] calcium channel activity [GO:0005262]; calcium:proton antiporter activity [GO:0015369] AVIWPQYVK;VATMLATGGNR 2 5.8 0.95516 -0.97945 0 0 12.7339 0 0 0 0 0 0 0 0 0 Q9H3K6 BOLA2_HUMAN BolA-like protein 2 BOLA2 BOLA2A My016; BOLA2B Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634] "2 iron, 2 sulfur cluster binding [GO:0051537]; iron-sulfur cluster binding [GO:0051536]" ELSAEYLREK;TLTPDQWAR 2 22.1 0.95486 -0.83552 0 0 0 0 0 0 0 11.6083 0 0 0 0 Q9H3L0 MMAD_HUMAN "Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial)" MMADHC C2orf25 CL25022 HSPC161 My011 Homo sapiens (Human) cobalamin metabolic process [GO:0009235] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ANVLCNRARLVSYLPGFCSLVK;MANVLCNR 2 7.8 0.88924 -0.20757 0 0 0 0 0 0 9.39382 0 0 0 8.83611 0 Q9H3M0 KCNF1_HUMAN Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) KCNF1 Homo sapiens (Human) action potential [GO:0001508]; non-motile cilium assembly [GO:1905515]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transport [GO:0043266] ciliary base [GO:0097546]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] FLDDCCK;HHRTRLQSCK 2 3.4 0.95148 -0.6878 8.50752 0 5.3866 0 0 0 7.92582 7.62571 0 0 0 0 Q9H3N1 TMX1_HUMAN Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 Homo sapiens (Human) negative regulation of platelet aggregation [GO:0090331]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of ERAD pathway [GO:1904294]; regulation of calcium ion transport [GO:0051924]; response to endoplasmic reticulum stress [GO:0034976] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966] disulfide oxidoreductase activity [GO:0015036]; enzyme inhibitor activity [GO:0004857]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] DFINFISDKEWK;SLGPSLATDKS;VDVTEQPGLSGR 3 12.5 0.0046948 1.401 0 10.0817 0 0 0 0 9.29999 7.92961 8.49217 10.1849 0 0 Q9H3N8 HRH4_HUMAN Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144) HRH4 GPCR105 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of MAPK cascade [GO:0043408]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594] EHVELLRARR;RSLSASTEVPASFHSER 2 6.9 0.95711 -1.0271 8.94924 0 0 0 0 0 0 0 0 0 0 11.2357 Q9H3P2 NELFA_HUMAN Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) NELFA WHSC2 P/OKcl.15 Homo sapiens (Human) negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090] SAGVPFHAK 1 1.7 0.60736 0.17657 0 0 0 0 0 0 0 0 0 0 7.91654 0 Q9H3P7 GCP60_HUMAN "Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]" ACBD3 GCP60 GOCAP1 GOLPH1 Homo sapiens (Human) steroid biosynthetic process [GO:0006694] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739] fatty-acyl-CoA binding [GO:0000062]; protein kinase A regulatory subunit binding [GO:0034237] EDAMVEFVK;REEEERER 2 3.2 0.93327 -0.51462 0 0 0 0 0 0 0 8.39193 0 0 0 0 Q9H3Q1 BORG4_HUMAN Cdc42 effector protein 4 (Binder of Rho GTPases 4) CDC42EP4 BORG4 CEP4 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] RNA binding [GO:0003723]; small GTPase binding [GO:0031267] QLVSSSVHSK 1 2.8 0.93556 -0.52036 0 0 0 0 0 9.6544 0 0 0 0 0 0 Q9H3Q3 G3ST2_HUMAN "Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Glycoprotein beta-Gal 3'-sulfotransferase 2)" GAL3ST2 GP3ST Homo sapiens (Human) glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101] Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020] galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146] FNIMCNHLRFNLPQVQK;LSPETRER;LVLIAEHLDESLVLLR 3 10.3 0.96352 -1.1065 5.07425 0 0 11.1914 0 0 5.06544 0 0 0 0 12.705 Q9H3R0 KDM4C_HUMAN Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) KDM4C GASC1 JHDM3C JMJD2C KIAA0780 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] enzyme binding [GO:0019899]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; zinc ion binding [GO:0008270] EDIYTLDEELPK;LDEVVTSEGK;VAKLCTCRK 3 2.9 0.97824 -1.9283 0 0 0 0 0 9.97857 0 0 0 0 7.94351 0 Q9H3R1 NDST4_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] NDST4 HSST4 Homo sapiens (Human) "heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; N-acetylglucosamine deacetylase activity [GO:0050119] DIWSREK;QTCGLFTHTIFYK 2 2.3 0.896 -0.24961 8.75054 0 0 0 0 6.92077 0 9.53035 0 7.16098 0 0 Q9H3R2 MUC13_HUMAN Mucin-13 (MUC-13) (Down-regulated in colon cancer 1) MUC13 DRCC1 RECC UNQ6194/PRO20221 Homo sapiens (Human) maintenance of gastrointestinal epithelium [GO:0030277] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] HSSMPRPDY 1 1.8 0.9103 -0.31648 6.89263 0 0 0 0 0 0 0 0 0 0 0 Q9H3R5 CENPH_HUMAN Centromere protein H (CENP-H) (Interphase centromere complex protein 35) CENPH ICEN35 Homo sapiens (Human) chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; kinetochore organization [GO:0051383]; mitotic spindle organization [GO:0007052] chromosome [GO:0005694]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] kinetochore binding [GO:0043515] KNLEKISR;SQQESWDLEEKLLDIR 2 9.7 0.97877 -1.9201 0 0 13.2821 0 0 0 0 8.95934 0 0 0 0 Q9H3S1 SEM4A_HUMAN Semaphorin-4A (Semaphorin-B) (Sema B) SEMA4A SEMAB SEMB UNQ783/PRO1317 Homo sapiens (Human) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of inhibitory synapse assembly [GO:1905704]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; semaphorin-plexin signaling pathway [GO:0071526]; T-helper 1 cell differentiation [GO:0045063] plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] IPWPASDR;MIPWPASDRKK 2 1.7 0.95257 -0.7516 0 0 0 0 0 0 0 0 0 0 5.8017 0 Q9H3S5 PIGM_HUMAN GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M) PIGM Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529] "alpha-1,4-mannosyltransferase activity [GO:0051751]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]" HWGEWLLNLK;SPYLRATYRYTPLLGWLLTPNIYLSELFGK;VALVFYGVFQDRTLHVR 3 13.5 0.9639 -1.201 0 5.17768 0 0 0 0 10.4874 10.7099 0 0 0 0 Q9H3S7 PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) PTPN23 KIAA1471 Homo sapiens (Human) cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" AALPTPALSPEDK;KKPPPRPTAPKPLLPRR;KPPPRPTAPKPLLPRR;QLQQELEAFR;VDAAEGR;VSEEGMK 6 3.3 0.95507 -0.94561 13.801 10.8714 10.3242 0 0 8.76328 10.081 12.0332 10.0518 0 10.4542 10.4953 Q9H3T2 SEM6C_HUMAN Semaphorin-6C (Semaphorin-Y) (Sema Y) SEMA6C KIAA1869 SEMAY Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] ALDRHWTSFLKLR;FLTLNRTLLVAAR 2 2.8 0.97545 -1.4724 0 0 0 6.14519 0 0 0 0 0 0 0 0 Q9H3U1 UN45A_HUMAN Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) UNC45A SMAP1 Homo sapiens (Human) cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879] AAQALAK;DLYKCSEKDSIR;LAKQCRK;LCENYIK;VFQEALRNIGGQIQEKVR 5 5.4 0.9748 -1.4297 16.1238 16.3013 0 0 0 0 11.3688 0 10.3968 11.8485 0 0 Q9H3U5 MFSD1_HUMAN Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Smooth muscle cell-associated protein 4) (SMAP-4) MFSD1 SMAP4 UG0581B09 Homo sapiens (Human) dipeptide transmembrane transport from lysosomal lumen to cytosol [GO:0141204]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821] lysosomal membrane [GO:0005765]; lysosome [GO:0005764] dipeptide uniporter activity [GO:0160178]; protein homodimerization activity [GO:0042803] LLVLLLMCFLGFAIFAMIILLPFRLK 1 6.1 0.84219 -0.043106 0 0 0 0 0 7.51633 0 0 0 0 0 0 Q9H3U7 SMOC2_HUMAN SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2) SMOC2 SMAP2 MSTP117 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular wound healing [GO:0035470] basement membrane [GO:0005604]; cell periphery [GO:0071944]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201] CVAERKYTQEQAR 1 2.9 0.86916 -0.091336 0 11.8043 0 0 0 0 0 0 0 0 0 0 Q9H3W5 LRRN3_HUMAN Leucine-rich repeat neuronal protein 3 (Neuronal leucine-rich repeat protein 3) (NLRR-3) LRRN3 Nbla10363 UNQ194/PRO220 Homo sapiens (Human) positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] GLHPDQK;LIKVPHVALQKVVNLK 2 3.2 0.91025 -0.28213 0 0 3.71984 0 0 0 0 0 0 0 0 0 Q9H3Y6 SRMS_HUMAN Tyrosine-protein kinase Srms (EC 2.7.10.2) SRMS C20orf148 Homo sapiens (Human) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of TORC1 signaling [GO:1904263] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] LFPGLEELLTYYK 1 2.7 0.89605 -0.23686 0 0 0 7.99232 0 0 9.58564 0 0 7.95611 0 0 Q9H3Z7 ABHGB_HUMAN ABHD16B (EC 3.1.1.111) (Alpha/beta hydrolase domain-containing protein 16B) (Abhydrolase domain-containing protein 16B) ABHD16B C20orf135 Homo sapiens (Human) monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660] nucleoplasm [GO:0005654] monoacylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620] RQHPGSHVHGPR 1 2.6 0.67147 0.16802 0 0 0 0 7.55857 0 0 0 0 0 0 0 Q9H410 DSN1_HUMAN Kinetochore-associated protein DSN1 homolog DSN1 C20orf172 MIS13 Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; skeletal muscle satellite cell proliferation [GO:0014841] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] LEPFLRDTKGFSLESFR;RSMQQLDPSPARK 2 8.4 0.96063 -1.0558 0 0 0 0 10.7017 0 0 11.4753 0 0 0 0 Q9H422 HIPK3_HUMAN Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) HIPK3 DYRK6 FIST3 PKY Homo sapiens (Human) apoptotic process [GO:0006915]; mRNA transcription [GO:0009299]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FSPLPLKVIRPILQQVATALK;QDSDSSVSDKQR;VIDFGSASHVSK;VIRPILQQVATALKKLK 4 4 0.96645 -1.2696 4.66778 3.75414 0 0 5.94909 0 0 8.46218 0 0 0 10.5287 Q9H425 CA198_HUMAN Uncharacterized protein C1orf198 C1orf198 Homo sapiens (Human) cytosol [GO:0005829] INAERSR;QEPAPKDREAK 2 5.5 0.96541 -1.2142 0 0 0 8.81205 0 8.60151 0 9.77437 0 0 0 0 Q9H427 KCNKF_HUMAN Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3) (Two pore K(+) channel KT3.3) KCNK15 TASK5 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] LNAVVRRLLLAAK 1 3.9 0.86957 -0.094963 0 3.85828 0 0 0 0 0 0 0 0 0 0 Q9H444 CHM4B_HUMAN Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) CHMP4B C20orf178 SHAX1 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; maintenance of lens transparency [GO:0036438]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] EALENANTNTEVLK;GGPTPQEAIQR;IEQELTAAK;LFGAGGGK 4 18.8 0.97664 -2.1931 0 0 0 0 9.43552 7.72744 0 0 0 0 0 0 Q9H461 FZD8_HUMAN Frizzled-8 (Fz-8) (hFz8) FZD8 Homo sapiens (Human) angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; T cell differentiation in thymus [GO:0033077] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] GGGGGGK;SLCTRCCWASK 2 2.6 0.91046 -0.28838 8.29434 9.67716 0 0 0 0 0 0 0 12.3737 0 0 Q9H467 CUED2_HUMAN CUE domain-containing protein 2 CUEDC2 C10orf66 HOYS6 Homo sapiens (Human) negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of macrophage cytokine production [GO:0010936] cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ubiquitin binding [GO:0043130] KLIRYIDNQVVSTK;LSGQLSDARNK 2 8.7 0.90532 -0.27083 4.90448 0 0 0 0 0 0 0 0 0 8.47395 0 Q9H469 FXL15_HUMAN F-box/LRR-repeat protein 15 (F-box only protein 37) FBXL15 FBXO37 Homo sapiens (Human) bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ALGALAEGCPRLQRLSLAHCDWVDGLALR;GLADRCPALEELDLTACRQLK;VGSDGVRTLAEYCPVLR 3 22.3 0.91766 -0.4202 0 0 0 0 3.80622 4.48697 0 0 0 9.67502 0 0 Q9H488 OFUT1_HUMAN GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) POFUT1 FUT12 KIAA0180 Homo sapiens (Human) angiogenesis [GO:0001525]; fucose metabolic process [GO:0006004]; heart development [GO:0007507]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; O-glycan processing [GO:0016266]; protein O-linked fucosylation [GO:0036066]; protein O-linked glycosylation [GO:0006493]; regulation of DNA-templated transcription [GO:0006355]; regulation of Notch signaling pathway [GO:0008593]; somitogenesis [GO:0001756] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] fucosyltransferase activity [GO:0008417]; peptide-O-fucosyltransferase activity [GO:0046922] EQWSQRFSPK;SPDKKTCPMK 2 5.2 0.97253 -2.7441 0 10.5509 0 9.47224 0 0 0 0 0 0 0 0 Q9H489 TSY26_HUMAN Putative testis-specific Y-encoded-like protein 3 (TSPY-like protein 3) (Testis-specific Y-encoded protein 26 pseudogene) TSPY26P TSPYL3 Homo sapiens (Human) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] AGTPEAAARPPPGLAR;IRWHWGQEPPALVHRNR 2 9.3 0.84092 -0.04135 0 0 0 0 0 8.92455 10.5256 0 0 0 0 0 Q9H490 PIGU_HUMAN Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) PIGU CDC91L1 PSEC0205 UNQ3055/PRO9875 Homo sapiens (Human) attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; plasma membrane [GO:0005886] AAPLVLVLVVAVTVRAALFR;REYYLTHGLYLTAKDGTEAMLVLK 2 10.1 0.90189 -0.26124 0 0 6.17167 0 0 0 0 9.33087 0 0 0 0 Q9H496 IFG15_HUMAN "Torsin-1A-interacting protein 2, isoform IFRG15 (15 kDa interferon-responsive protein) (IFRG15)" TOR1AIP2 IFRG15 Homo sapiens (Human) RIHDSRVAGFNPALQLILTR 1 15.3 0.463 0.19077 0 0 0 0 0 0 0 0 0 5.38094 0 0 Q9H497 TOR3A_HUMAN Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) TOR3A ADIR Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] MLRGPWR;MLVENLYR;SISQRINYFLS 3 6.5 0.9746 -2.4076 0 0 0 0 0 0 0 10.0677 9.95861 0 0 11.861 Q9H4A3 WNK1_HUMAN Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) WNK1 HSN2 KDP KIAA0344 PRKWNK1 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic cation homeostasis [GO:0055080]; monoatomic ion transport [GO:0006811]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; non-membrane-bounded organelle assembly [GO:0140694]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; protein phosphorylation [GO:0006468]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transport [GO:0002028]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DLLNHAFFQEETGVR;EIIEGCIR;MSGGAAEK;VCPCNQLCR;VPPAVIIPPAAPLSGR 5 2 0.95809 -1.0145 0 5.09917 11.0028 0 0 0 0 0 6.54077 0 0 0 Q9H4A4 AMPB_HUMAN Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) RNPEP APB Homo sapiens (Human) proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270] AEFGPPGPGAGSR;ASGEHSPGSGAAR;LGDTYPSISNAR 3 5.8 0 2.879 0 0 0 5.9518 0 7.32211 0 0 0 10.7565 10.3788 0 Q9H4A5 GLP3L_HUMAN Golgi phosphoprotein 3-like (GPP34-related protein) GOLPH3L GPP34R Homo sapiens (Human) "Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; positive regulation of protein secretion [GO:0050714]; protein targeting to Golgi apparatus [GO:0140450]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] cargo adaptor activity [GO:0140312]; phosphatidylinositol-4-phosphate binding [GO:0070273] IAKNLVEKGILTTEK;LQDSVLER;WVNDPQRMDK 3 11.6 0.95577 -0.86923 10.9892 0 0 0 8.76633 0 0 0 0 0 0 0 Q9H4A6 GOLP3_HUMAN Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) GOLPH3 GPP34 Homo sapiens (Human) "asymmetric Golgi ribbon formation [GO:0090164]; cell adhesion molecule production [GO:0060352]; cell migration [GO:0016477]; cellular response to rapamycin [GO:0072752]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; lamellipodium assembly [GO:0030032]; leukocyte tethering or rolling [GO:0050901]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]; positive regulation of TOR signaling [GO:0032008]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; protein targeting to Golgi apparatus [GO:0140450]; regulation of mitochondrion organization [GO:0010821]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cargo adaptor activity [GO:0140312]; enzyme binding [GO:0019899]; phosphatidylinositol-4-phosphate binding [GO:0070273] DEQDDDDK;DEQDDDDKGDSK;LQLEACGMRRK;LTLMEEVLLLGLKDR 4 12.8 0.97868 -2.106 0 0 0 9.08438 0 8.87673 0 8.99226 0 0 0 4.14902 Q9H4A9 DPEP2_HUMAN Dipeptidase 2 (EC 3.4.13.19) DPEP2 UNQ284/PRO323 Homo sapiens (Human) leukotriene D4 catabolic process [GO:1901749]; leukotriene metabolic process [GO:0006691]; proteolysis [GO:0006508] membrane [GO:0016020]; side of membrane [GO:0098552] dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] ALTTLGAPR;AVIGSKFIGIGGDYDGAGK;GVCNSARNVPDDILQLLK;LTLEQIDLIRR 4 11.7 0.98064 -1.6218 0 0 0 5.90761 0 0 9.62688 9.15568 0 0 0 0 Q9H4B0 OSGL1_HUMAN "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (OSGEP-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1)" OSGEPL1 GCP1 Homo sapiens (Human) tRNA threonylcarbamoyladenosine modification [GO:0002949] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711] AILFCKQR;EVGEASIKVPQLK 2 5.1 0.9786 -1.9745 0 0 0 0 0 0 0 0 0 0 0 11.5787 Q9H4B4 PLK3_HUMAN Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) PLK3 CNK FNK PRK Homo sapiens (Human) "apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endomitotic cell cycle [GO:0007113]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; mitotic G1/S transition checkpoint signaling [GO:0044819]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chaperone-mediated autophagy [GO:1904716]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein phosphorylation [GO:0006468]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to osmotic stress [GO:0006970]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi stack [GO:0005795]; kinetochore [GO:0000776]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] TVHYNPTSTK;WVDYSNK 2 2.6 0.86601 -0.088874 0 0 0 0 0 0 0 0 0 0 8.7086 0 Q9H4B6 SAV1_HUMAN Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) SAV1 WW45 Homo sapiens (Human) cardiac muscle cell proliferation [GO:0060038]; epithelial cell proliferation [GO:0050673]; hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte apoptotic process [GO:0097283]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of keratinocyte apoptotic process [GO:1902174]; protein stabilization [GO:0050821]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; transcription regulator activator activity [GO:0140537] NQSFLRTPIQR;WELFQLADLDTYQGMLKLLFMKELEQIVK 2 10.4 0.97788 -1.5124 0 0 0 0 0 0 8.06674 0 0 0 9.54137 0 Q9H4B8 DPEP3_HUMAN Dipeptidase 3 DPEP3 UNQ834/PRO1772 Homo sapiens (Human) proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] dipeptidase activity [GO:0016805] LLLLLLLLLLR;LLLLLLLLLLRQPVTR;RLLLLLLLLLLR;YLRRLLLLLLLLLLR 4 4.1 0.079872 0.40008 10.3592 4.55655 0 0 3.7 0 3.62012 8.15598 0 4.91318 3.89889 3.91332 Q9H4E5 RHOJ_HUMAN Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein) RHOJ ARHJ RASL7B RHOI TCL Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; angiogenesis [GO:0001525]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; regulation of sprouting angiogenesis [GO:1903670]; retina vasculature morphogenesis in camera-type eye [GO:0061299] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] AIGAQCYLECSALTQK;MNCKEGTDSSCGCRGNDEK;TLARLLYMKEKPLTYEHGVK 3 25.7 0.072464 0.41316 0 0 0 0 9.56961 0 0 0 0 8.76471 0 12.2106 Q9H4E7 DEFI6_HUMAN Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) DEF6 IBP Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport to the plasma membrane [GO:0098876] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LLQEEEER;SLQQAQQQLEEVRQNRQR;YILDKVEEGAFVK 3 6.2 0.9417 -0.61863 0 0 0 0 0 0 0 0 0 7.50851 0 0 Q9H4F1 SIA7D_HUMAN "Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.7) (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (ST6GalNAcIV) (Sialyltransferase 3C) (SIAT3-C) (Sialyltransferase 7D) (SIAT7-D)" ST6GALNAC4 SIAT3C SIAT7D Homo sapiens (Human) ganglioside biosynthetic process [GO:0001574]; glycolipid metabolic process [GO:0006664]; O-glycan processing [GO:0016266]; oligosaccharide metabolic process [GO:0009311]; viral protein processing [GO:0019082] Golgi membrane [GO:0000139] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity [GO:0047290]; sialyltransferase activity [GO:0008373]" VLGGRTYR 1 2.6 0.91333 -0.33804 0 0 0 0 0 6.68762 0 0 0 10.956 0 0 Q9H4F8 SMOC1_HUMAN SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) SMOC1 Homo sapiens (Human) cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667] basement membrane [GO:0005604]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201] AQALEQAK;DAGQSKCRLER;LLTPHLLLVLVQLSPARGHR 3 9 0.93531 -0.52905 5.79293 12.0708 6.55082 0 6.94017 8.98624 0 7.35826 0 0 0 0 Q9H4G0 E41L1_HUMAN Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) EPB41L1 KIAA0338 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin binding [GO:0003779]; structural molecule activity [GO:0005198] ELKPEQETTPRHK;FAPNQTRELEERIMELHK 2 3.5 0.96519 -1.218 0 0 0 0 0 0 11.9727 0 0 8.97008 0 0 Q9H4G0 E41L1_HUMAN Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) EPB41L1 KIAA0338 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin binding [GO:0003779]; structural molecule activity [GO:0005198] FAPNQTRELEERIMELHK;INEVEPAK 2 3.7 0.93738 -0.5757 0 12.4622 0 0 0 0 0 0 0 0 0 0 Q9H4G4 GAPR1_HUMAN Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139] protein homodimerization activity [GO:0042803] GQCGENLAWASYDQTGK 1 11 0.92149 -0.44127 0 0 0 0 0 0 0 0 0 0 0 10.3136 Q9H4H8 FA83D_HUMAN Protein FAM83D (Spindle protein CHICA) FAM83D C20orf129 Homo sapiens (Human) cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; epithelial to mesenchymal transition [GO:0001837]; metaphase chromosome alignment [GO:0051310]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; protein localization to mitotic spindle [GO:1902480]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein catabolic process [GO:0042176]; regulation of TOR signaling [GO:0032006]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819] kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] KADLDPEMPAEGKAER;VNLLAVRDVALYPSYQ 2 5.5 0.86526 -0.089487 0 0 0 0 0 0 8.65173 0 0 7.90358 0 0 Q9H4I2 ZHX3_HUMAN Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) ZHX3 KIAA0395 TIX1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" AVADTGSEDQGPGTGELTAVHK;RYHCRNLK 2 3.1 0.96177 -1.0704 13.2201 0 0 0 0 0 8.66747 0 0 0 0 0 Q9H4I8 SEHL2_HUMAN Serine hydrolase-like protein 2 (EC 3.1.-.-) SERHL2 SERHL Homo sapiens (Human) perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777] hydrolase activity [GO:0016787] ELCAHSIRKLQAHVLLIK;GTTKVATGLVLNR 2 9.9 0.90102 -0.26027 0 0 0 7.95965 0 0 0 0 0 9.06811 0 0 Q9H4K1 RIBC2_HUMAN RIB43A-like with coiled-coils protein 2 RIBC2 C22orf11 Homo sapiens (Human) flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] DLDWDRRR 1 2.1 0.86996 -0.095167 0 0 0 8.73981 0 0 0 0 0 0 0 0 Q9H4K7 MTG2_HUMAN Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) (Protein obg homolog 1) (ObgH1) MTG2 GTPBP5 OBGH1 Homo sapiens (Human) regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]; ribosome biogenesis [GO:0042254] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287] VPVGTLVK;YFVDYRR 2 3.7 0.95719 -1.0264 0 7.65835 0 0 0 0 0 0 10.5001 0 0 0 Q9H4L4 SENP3_HUMAN Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) SENP3 SSP3 SUSP3 Homo sapiens (Human) negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deSUMOylase activity [GO:0016929] TITYFDSQRTLNR 1 2.3 0.92192 -0.44524 0 0 0 0 8.76881 0 0 0 0 0 0 0 Q9H4L5 OSBL3_HUMAN Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) OSBPL3 KIAA0704 ORP3 OSBP3 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; filopodium tip [GO:0032433]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; sterol transfer activity [GO:0120015] IEQLQRER;LCEELEYSELLDK;NFVFWQDVRWK 3 3.6 0.97673 -2.2038 0 0 0 9.4288 0 5.62012 0 10.2422 10.7004 0 0 0 Q9H4L7 SMRCD_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) SMARCAD1 KIAA1122 Homo sapiens (Human) chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; heterochromatin formation [GO:0031507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA recombination [GO:0000018] chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; nucleosome array spacer activity [GO:0140750]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; ubiquitin binding [GO:0043130] LDHGEESNESAESSSNWEK;VGQTKEVLVIK 2 2.9 0.97924 -1.9149 0 0 0 0 0 10.7773 0 0 0 0 0 0 Q9H4M3 FBX44_HUMAN F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A Homo sapiens (Human) ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; proteasomal protein catabolic process [GO:0010498]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] APAALTPPEPPSAEP 1 6.7 0.89302 -0.22075 0 0 0 0 0 0 8.80439 0 0 0 0 0 Q9H4M7 PKHA4_HUMAN Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) PLEKHA4 PEPP1 Homo sapiens (Human) "positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ATLCHLTQERER;LSRGRGRPR 2 2.7 0.92985 -0.46974 0 0 7.86375 0 0 0 0 10.377 0 0 0 0 Q9H4M9 EHD1_HUMAN EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) EHD1 PAST PAST1 CDABP0131 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neuron projection development [GO:0010976]; protein homooligomerization [GO:0051260]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659] ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; presynaptic active zone [GO:0048786]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] ELVNNLGEIYQK 1 2.2 0.93715 -0.56764 7.2341 0 0 7.66228 7.03573 0 0 0 8.87231 0 0 0 Q9H4P4 RNF41_HUMAN E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) RNF41 FLRF NRDP1 SBBI03 Homo sapiens (Human) autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377] cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471] erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DELPNHNCIKHLR;MGYDVTR;NMLSKLQIACDNAVFGCSAVVR 3 13.2 0.96367 -1.2039 0 0 6.92671 0 0 6.22178 0 0 0 0 9.22362 0 Q9H4Q4 PRD12_HUMAN PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12) PRDM12 PFM9 Homo sapiens (Human) detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; neuron projection development [GO:0031175]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; sensory perception of pain [GO:0019233] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone chaperone activity [GO:0140713]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] SHMRIHTLDKPFVCR 1 4.1 0.89705 -0.2361 0 0 9.02583 0 0 0 0 0 0 0 0 0 Q9H4S2 GSX1_HUMAN GS homeobox 1 (Homeobox protein GSH-1) GSX1 GSH1 Homo sapiens (Human) adenohypophysis development [GO:0021984]; central nervous system development [GO:0007417]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" TAFTSTQLLELEREFASNMYLSR 1 8.7 0.8338 -0.029624 0 0 0 0 0 0 0 8.29444 0 0 0 0 Q9H4T2 ZSC16_HUMAN Zinc finger and SCAN domain-containing protein 16 (Zinc finger protein 392) (Zinc finger protein 435) ZSCAN16 ZNF392 ZNF435 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KTQLEQEAGKPQRNGDK;LNKDTPQHPK;VSSALIR 3 9.8 0.9362 -0.55169 0 0 0 0 0 9.54009 9.15023 11.2138 0 0 0 8.75205 Q9H4W6 COE3_HUMAN Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF-like 2) (O/E-2) (OE-2) EBF3 COE3 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MFGIQENIPRGGTTMK 1 2.7 0.88146 -0.16806 0 0 0 0 0 0 0 0 0 8.73247 0 0 Q9H4X1 RGCC_HUMAN Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) RGCC C13orf15 RGC32 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; complement activation [GO:0006956]; fibroblast activation [GO:0072537]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cytokine production [GO:0001818]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of exit from mitosis [GO:0001100]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412] SSASVSDSSGFSDSESADSLYR 1 16.1 0.67849 0.1655 0 0 0 0 0 0 0 0 0 8.47277 0 0 Q9H4Y5 GSTO2_HUMAN Glutathione S-transferase omega-2 (GSTO-2) (EC 2.5.1.18) (Glutathione S-transferase omega 2-2) (GSTO 2-2) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) GSTO2 Homo sapiens (Human) cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491] ECLVALRCGR;MRFCPYSHR;MRFCPYSHRTR 3 9.8 0.97405 -3.0338 0 2.99968 0 0 0 0 10.5265 0 0 11.7794 0 0 Q9H4Z2 ZN335_HUMAN Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) ZNF335 Homo sapiens (Human) brain development [GO:0007420]; brain morphogenesis [GO:0048854]; cerebral cortex neuron differentiation [GO:0021895]; epigenetic regulation of gene expression [GO:0040029]; in utero embryonic development [GO:0001701]; neuron projection morphogenesis [GO:0048812]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944] histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976] AEMESHK;ATSSMPESER;CDECSYTSVYR;CEFCEFVCEDK;KYYYKSPKPLLRPFLCR;YYYKSPKPLLRPFLCR 6 4.7 0.97231 -2.7301 0 9.96233 0 0 0 10.2788 6.77847 5.82601 5.65972 0 0 0 Q9H4Z3 CAPAM_HUMAN mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) PCIF1 C20orf67 CAPAM PPP1R121 Homo sapiens (Human) methylation [GO:0032259]; mRNA processing [GO:0006397]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727] intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047] ELCQQREGIEPPR;MANENHGSPR 2 3.3 0.91847 -0.40216 0 0 0 0 0 0 0 0 0 0 7.92659 6.83276 Q9H501 ESF1_HUMAN ESF1 homolog (ABT1-associated protein) ESF1 ABTAP C20orf6 HDCMC28P Homo sapiens (Human) rRNA processing [GO:0006364] extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] FKLNYAVDK;GKENDMEMEIK;IVEHQNLSK;LTPWEQFLEK;TEQFQAR 5 5.4 0.9723 -2.6884 0 0 0 8.21461 0 7.824 9.21561 7.65134 7.65607 9.69262 0 0 Q9H503 BAFL_HUMAN Barrier-to-autointegration factor-like protein (BAF-L) (Barrier-to-autointegration factor 2) BANF2 BAFL C20orf179 Homo sapiens (Human) chromosome organization [GO:0051276] condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] AYILLGQFLLMHKNEAEFQR;WLICCFGATECEAQQTSHCLK 2 45.6 0.71189 0.15202 0 12.1372 0 0 5.01592 0 0 0 0 0 0 0 Q9H553 ALG2_HUMAN "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)" ALG2 UNQ666/PRO1298 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "alpha-1,3-mannosyltransferase activity [GO:0000033]; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity [GO:0102704]" ATMGLAGRAR;LDDLVPK;LVLDAALALQARGCSVK 3 8.2 0.96369 -1.1113 11.6078 0 0 0 0 0 0 0 2.91455 0 0 9.84822 Q9H560 ANR19_HUMAN Putative ankyrin repeat domain-containing protein 19 (Ankyrin repeat domain-containing protein 19 pseudogene) ANKRD19P ANKRD19 Homo sapiens (Human) SIQQQILEHKNKILK 1 5.7 0.85995 -0.081818 0 0 0 8.31556 0 0 0 0 0 0 0 0 Q9H568 ACTL8_HUMAN Actin-like protein 8 (Cancer/testis antigen 57) (CT57) ACTL8 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; skeletal muscle thin filament assembly [GO:0030240] actin filament [GO:0005884]; stress fiber [GO:0001725]; striated muscle thin filament [GO:0005865] AARTVIIDHGSGFLK 1 4.1 0.91981 -0.43692 0 0 0 0 0 8.79347 0 0 0 0 0 0 Q9H579 MROH8_HUMAN Protein MROH8 (Maestro heat-like repeat-containing protein family member 8) MROH8 C20orf131 C20orf132 Homo sapiens (Human) CHNEPAQEK;FKDWLQDGNHLFR;HLAEVWR;IVLSAIQILLQLVR 4 4.9 0.98149 -1.5787 0 8.18145 0 0 0 0 0 0 8.65023 12.2276 0 0 Q9H582 ZN644_HUMAN Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) ZNF644 KIAA1221 ZEP2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]" KHTEYLHSSSCVDSFGSPLGLDK;SIAQSGVNMCNQNSSPHK 2 3.1 0.84795 -0.067328 0 0 0 0 0 0 13.6677 4.77689 0 0 0 0 Q9H583 HEAT1_HUMAN "HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]" HEATR1 BAP28 UTP10 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; neural precursor cell proliferation [GO:0061351]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit biogenesis [GO:0042274]; rRNA metabolic process [GO:0016072]" 90S preribosome [GO:0030686]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] RNA binding [GO:0003723]; snoRNA binding [GO:0030515] FWRALLSKAYDLLDK;LIAPERKEEK;LLTFYNLADCIAEKLK;LRSPQILVPTLFNLLSR;LSPDGGK;LVPDLLAIVQRK;MVEDLISVGEEESFNLKQK;RLPILVQLVDTLGAEK;TLATTLAPRVLLPAIKK;TLERSVQTK;VLLPAIK;VLLPAIKKTYK;VRFAALITVLALAEKLK 13 7.4 0.97477 -3.2097 2.62361 3.50906 0 7.20955 11.027 8.76451 0 0 9.62589 8.9372 0 9.39077 Q9H596 DUS21_HUMAN Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21) DUSP21 LMWDSP21 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; peptidyl-tyrosine dephosphorylation [GO:0035335] axonemal A tubule inner sheath [GO:0160111]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" SLFLSNGVAANDK 1 6.8 0.91308 -0.39029 0 0 0 11.832 0 0 0 0 0 0 0 0 Q9H598 VIAAT_HUMAN Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT) SLC32A1 VGAT VIAAT Homo sapiens (Human) beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]; hippocampus development [GO:0021766]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269] cell surface [GO:0009986]; cell tip [GO:0051286]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; dendrite terminus [GO:0044292]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; gamma-aminobutyric acid:proton symporter activity [GO:0015495]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799] ATLLRSKLSNVATSVSNK;MSGMFAR;VRDSYVAIANACCAPRFPTLGGR 3 9.1 0.97654 -1.4883 0 11.7001 5.28225 0 7.9969 0 0 7.85487 0 0 0 0 Q9H5I1 SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 KMT1B Homo sapiens (Human) "cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian rhythm [GO:0007623]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]" "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; S-adenosyl-L-methionine binding [GO:1904047]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270] CQCGPDCPNR 1 2.4 0.81492 -0.0020686 0 0 0 0 5.45062 0 0 0 5.76744 0 0 0 Q9H5I5 PIEZ2_HUMAN Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) PIEZO2 C18orf30 C18orf58 FAM38B Homo sapiens (Human) cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; monoatomic cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to mechanical stimulus [GO:0009612] cuticular plate [GO:0032437]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261] AIAEIWPK;ARQQKYK;DSSDSLK;EALLSEVKIGSQENEEK;EFIGNMITTAGK;ESEKRYPQPR;FLEYFHK;GDLGKDSEESEEDGEEEEESEEEEETSDLR;IWLQEPLVQDEGTKEEDK;NLSLGAK;QFTVAELFTR;QGTTETIEEVEAEQEEEAGSTAPEPREAK;SAFQFVYQAWITDPK;SPETMIK;VPGFLEK;WEPSDESSEK 16 7.3 0.9752 -4.2615 11.1751 8.68191 13.525 8.6953 9.23542 0 0 9.62458 0 9.93665 11.5004 0 Q9H5J0 ZBTB3_HUMAN Zinc finger and BTB domain-containing protein 3 ZBTB3 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" AVLASCSPFFQLFYK 1 2.6 0.78085 0.032404 0 0 0 0 0 0 0 10.9133 0 0 0 0 Q9H5J8 TAF1D_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) TAF1D JOSD3 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] DNA binding [GO:0003677]; identical protein binding [GO:0042802] RNPIYSLIDKK 1 4 0.86953 -0.090953 0 0 3.7995 0 0 0 0 0 0 0 0 0 Q9H5L6 THAP9_HUMAN DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9) THAP9 Homo sapiens (Human) DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; transposase activity [GO:0004803] KILKLPHSSILR 1 1.3 0.963 -1.1011 0 8.8899 0 0 0 0 0 0 0 0 0 0 Q9H5N1 RABE2_HUMAN Rab GTPase-binding effector protein 2 (Rabaptin-5beta) RABEP2 RABPT5B Homo sapiens (Human) cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096] ASLEGQLR;QAETLEQVR 2 3 0.95758 -1.0172 0 0 0 0 10.3476 0 0 0 0 0 0 0 Q9H5P4 PDZD7_HUMAN PDZ domain-containing protein 7 PDZD7 PDZK7 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; sensory perception of sound [GO:0007605] cilium [GO:0005929]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696] identical protein binding [GO:0042802] EMVSEYCWLDR;TYPRLDIEKEMGAT 2 4.9 0.95355 -0.89208 0 0 0 0 10.7106 0 6.2648 0 0 0 0 0 Q9H5Q4 TFB2M_HUMAN "Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2)" TFB2M NS5ATP5 Homo sapiens (Human) mitochondrial transcription [GO:0006390]; rRNA methylation [GO:0031167]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] "mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" DILMQIGKQEDEK;TFIPHLESLGK 2 6.1 0.91762 -0.42948 0 0 0 0 0 0 9.78842 0 0 9.6388 0 0 Q9H5U6 ZCHC4_HUMAN rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4) ZCCHC4 Homo sapiens (Human) positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737]; nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]; zinc ion binding [GO:0008270] DCNFFQWEDEK;FCSPCQRYVSLENQHCELCNSCTSKDGR;FYACSACR;SNKMKMETTK;YSQFYMEDSFCHYNMFNHHFFDGK 5 15.8 0.98067 -1.6453 0 0 0 0 0 0 5.06665 0 0 9.17807 6.22242 0 Q9H5V8 CDCP1_HUMAN CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318) CDCP1 TRASK UNQ2486/PRO5773 Homo sapiens (Human) extracellular region [GO:0005576]; plasma membrane [GO:0005886] HKISFLCDDLTR;QGLTVSFIPYFKEEGVFTVTPDTK 2 4.3 0.89343 -0.22122 10.422 0 0 8.37929 0 8.18809 0 0 0 0 0 7.30104 Q9H5V9 STEEP_HUMAN STING ER exit protein (STEEP) STEEP1 CXorf56 Homo sapiens (Human) endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein exit from endoplasmic reticulum [GO:0032527] cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674] FGQGFGK 1 3.2 0.93716 -0.56358 0 0 0 0 0 0 0 0 0 9.36929 0 0 Q9H5X1 CIA2A_HUMAN Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A) CIAO2A CIA2A FAM96A Homo sapiens (Human) chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosol [GO:0005829]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] VAAAMENPNLR;VLWLSGLSEPGAAR 2 15.6 0.89282 -0.21824 0 0 0 0 0 0 0 0 10.0402 9.57344 0 0 Q9H5Y7 SLIK6_HUMAN SLIT and NTRK-like protein 6 SLITRK6 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; auditory behavior [GO:0031223]; auditory receptor cell morphogenesis [GO:0002093]; axonogenesis [GO:0007409]; cochlea development [GO:0090102]; innervation [GO:0060384]; lens development in camera-type eye [GO:0002088]; linear vestibuloocular reflex [GO:0060007]; multicellular organism growth [GO:0035264]; positive regulation of synapse assembly [GO:0051965]; sensory perception of sound [GO:0007605]; startle response [GO:0001964]; synapse assembly [GO:0007416]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601] cell surface [GO:0009986]; plasma membrane [GO:0005886] GSCDSLCNCEEK;VLSPSGLLIHCQER 2 3.1 0.78219 0.02214 0 0 0 0 7.16189 0 0 0 4.8865 0 0 0 Q9H5Z1 DHX35_HUMAN Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35) DHX35 C20orf15 DDX35 Homo sapiens (Human) "in utero embryonic development [GO:0001701]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FHSTGAYR;KSSEGDPDLVLR 2 2.8 0.95771 -1.0301 12.4981 0 0 0 10.3794 0 0 0 0 0 0 0 Q9H5Z6 F124B_HUMAN Protein FAM124B FAM124B Homo sapiens (Human) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] LTSVSAKRTSEPR;VLNRENSFQK 2 5.1 0.96729 -1.3123 0 0 9.96896 0 0 0 0 0 0 0 0 11.7327 Q9H611 PIF1_HUMAN ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) PIF1 C15orf20 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomere maintenance via telomerase [GO:0032211]; protein-DNA-RNA complex disassembly [GO:0001117]; telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]" 5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA helicase activity [GO:0017116]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162] AQLLGPRPRDFVTISPVQPEER;VLDFDPMAVR 2 5 0.91791 -0.43488 0 5.37065 0 0 0 0 0 0 0 0 11.9921 0 Q9H649 NSUN3_HUMAN "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 3)" NSUN3 MSTP077 UG0651E06 Homo sapiens (Human) regulation of mitochondrial translation [GO:0070129]; rRNA methylation [GO:0031167]; tRNA wobble base cytosine methylation [GO:0002127] mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] methyltransferase activity [GO:0008168]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049] DGEKVLDLCAAPGGK;QICKVVLDHFEK;RNLPLLQIELLRSAIK;VSELDGRK 4 15 0.97845 -1.9093 0 0 0 0 0 10.6041 0 0 0 6.82629 0 5.71328 Q9H665 IGFR1_HUMAN IGF-like family receptor 1 (Transmembrane protein 149) (U2 small nuclear RNA auxiliary factor 1-like 4) IGFLR1 TMEM149 U2AF1L4 Homo sapiens (Human) nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ALIEMVVAR 1 2.5 0.93708 -0.56451 0 9.96359 0 0 0 0 0 0 0 0 0 0 Q9H668 STN1_HUMAN CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) STN1 OBFC1 Homo sapiens (Human) negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833] "chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; fibrillar center [GO:0001650]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" single-stranded DNA binding [GO:0003697]; single-stranded telomeric DNA binding [GO:0043047]; telomeric DNA binding [GO:0042162] AIHSIFK;QVPGVFLYNGHPIK 2 5.7 0.93687 -0.55683 0 10.8122 0 0 0 0 0 0 0 0 0 0 Q9H693 CP095_HUMAN Uncharacterized protein C16orf95 C16orf95 Homo sapiens (Human) VEAALPYWVPLSLRPR 1 10.1 0.61701 0.17415 0 5.44708 0 0 0 0 0 0 0 0 0 0 Q9H694 BICC1_HUMAN Protein bicaudal C homolog 1 (Bic-C) BICC1 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoplasm [GO:0005737] RNA binding [GO:0003723] NALNMYEAR;NALNMYEARK;VMEETGCHIHFPDSNR 3 2.7 0.96525 -1.2151 0 0 8.3249 0 0 0 0 0 0 0 0 8.63568 Q9H6A0 DEN2D_HUMAN DENN domain-containing protein 2D DENND2D Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] AGPPQDNSGEALK;ILEYEEQKKQK 2 5.1 0.94485 -0.63889 12.2825 0 0 0 0 0 0 8.85773 0 0 0 0 Q9H6A9 PCX3_HUMAN Pecanex-like protein 3 (Pecanex homolog protein 3) PCNX3 PCNXL3 Homo sapiens (Human) membrane [GO:0016020] GAAGGPR;YSTDSSSSTSCYSPESSR 2 1.2 0.64059 0.17248 4.34412 0 0 0 0 0 0 0 0 0 0 9.98499 Q9H6B1 Z385D_HUMAN Zinc finger protein 385D (Zinc finger protein 659) ZNF385D ZNF659 Homo sapiens (Human) nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] ALEAMKNK;LLYCSLCK 2 4.1 0.97776 -1.5151 0 0 0 9.86327 0 0 0 0 0 0 0 0 Q9H6B9 EPHX3_HUMAN Epoxide hydrolase 3 (EH3) (EC 3.3.2.10) (Abhydrolase domain-containing protein 9) EPHX3 ABHD9 Homo sapiens (Human) epoxide metabolic process [GO:0097176]; lipid metabolic process [GO:0006629] endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787] DVILGLGYSK;PELVVTALLAPSRLSLKLLR 2 8.3 0.90969 -0.27947 0 0 0 0 0 0 7.96815 7.50875 0 0 0 4.98048 Q9H6D7 HAUS4_HUMAN HAUS augmin-like complex subunit 4 HAUS4 C14orf94 Homo sapiens (Human) cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] microtubule minus-end binding [GO:0051011] ARLQQEVEEQLK;LLGPSQER;SEILHRVIQELLVDYYVK 3 10.5 0.96556 -1.1345 0 0 0 0 0 8.85599 0 0 0 8.73884 0 0 Q9H6E5 STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) TUT1 RBM21 Homo sapiens (Human) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; snRNA processing [GO:0016180]; U6 snRNA 3'-end processing [GO:0034477]" cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; U6 snRNA binding [GO:0017070] ASELAETPK;CCLCHVTTANRPSLDAHLGGR;EEQQGCAGDGGEDR;NCCEEGKEEQQGCAGDGGEDR 4 5.8 0.91055 -0.29326 8.25871 0 0 7.35667 0 8.52431 0 6.49317 0 8.93124 0 0 Q9H6F5 CCD86_HUMAN Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) CCDC86 CYCLON Homo sapiens (Human) chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] AGLGSPERPPK;DTLALLQK 2 5.3 0.8424 -0.051636 13.1406 12.9901 0 0 8.0926 0 0 13.5891 0 0 0 0 Q9H6H4 REEP4_HUMAN Receptor expression-enhancing protein 4 REEP4 C8orf20 PP432 Homo sapiens (Human) cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782] microtubule binding [GO:0008017] VVKRKPPVR 1 3.5 0.88234 -0.17886 0 0 0 0 6.71672 0 0 0 0 0 0 0 Q9H6I2 SOX17_HUMAN Transcription factor SOX-17 SOX17 Homo sapiens (Human) angiogenesis [GO:0001525]; cardiac cell fate determination [GO:0060913]; cardiogenic plate morphogenesis [GO:0003142]; cell migration involved in gastrulation [GO:0042074]; cellular response to leukemia inhibitory factor [GO:1990830]; common bile duct development [GO:0061009]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; endoderm formation [GO:0001706]; endodermal cell fate determination [GO:0007493]; endodermal cell fate specification [GO:0001714]; endodermal digestive tract morphogenesis [GO:0061031]; gallbladder development [GO:0061010]; gene expression [GO:0010467]; heart development [GO:0007507]; heart formation [GO:0060914]; heart looping [GO:0001947]; inner cell mass cellular morphogenesis [GO:0001828]; metanephros development [GO:0001656]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of cardiac cell fate specification [GO:2000043]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of stem cell division [GO:2000035]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; rostrocaudal neural tube patterning [GO:0021903]; signal transduction involved in regulation of gene expression [GO:0023019]; spermatogenesis [GO:0007283]; stem cell fate specification [GO:0048866]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" VQHMQDHPNYKYRPRR 1 3.9 0.84997 -0.075682 0 0 0 0 8.97811 0 0 0 0 0 0 0 Q9H6J7 CSTP1_HUMAN Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 CSTPP1 C11orf49 Homo sapiens (Human) regulation of protein complex stability [GO:0061635] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] protein-macromolecule adaptor activity [GO:0030674] AKEPGAFGFQRR 1 3.7 0.95997 -1.0542 0 0 0 0 0 9.82987 0 0 0 0 0 0 Q9H6K4 OPA3_HUMAN Optic atrophy 3 protein OPA3 Homo sapiens (Human) regulation of lipid metabolic process [GO:0019216]; visual perception [GO:0007601] mitochondrion [GO:0005739] AQLQEVR 1 3.9 0.92411 -0.44857 0 0 0 0 0 0 0 9.27794 0 0 0 0 Q9H6K5 PRR36_HUMAN Proline-rich protein 36 PRR36 Homo sapiens (Human) AAAGAGAGASSRSPKQAR;AKAGAAAR;APAHPSQPKPK;ISAEETVARGK 4 3.6 0.97468 -3.7604 0 0 0 0 0 0 0 0 10.3522 9.49837 9.32076 0 Q9H6L2 TM231_HUMAN Transmembrane protein 231 TMEM231 UNQ870/PRO1886 Homo sapiens (Human) camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944] ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038] SSAVTAR;SSYEEQPTVR 2 4.9 0.85083 -0.074909 0 0 6.0847 0 0 0 0 0 0 8.85434 0 0 Q9H6L5 RETR1_HUMAN Reticulophagy regulator 1 (Reticulophagy receptor 1) RETREG1 FAM134B JK1 Homo sapiens (Human) collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; mitophagy [GO:0000423]; negative regulation of neuron apoptotic process [GO:0043524]; reticulophagy [GO:0061709]; sensory perception of pain [GO:0019233]; white fat cell differentiation [GO:0050872] cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; nucleolus [GO:0005730] endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] LDFGIGEYINQK;LDFGIGEYINQKK 2 2.6 0.95153 -0.6928 0 0 0 0 10.8445 0 11.1164 0 0 0 0 0 Q9H6N6 MYH16_HUMAN Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) MYH16 MYH5 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; anatomical structure formation involved in morphogenesis [GO:0048646]; cellular component assembly [GO:0022607]; supramolecular fiber organization [GO:0097435] myosin complex [GO:0016459] AIESLQASLEAEAKGR;ECRMYMTESFK;LEGELSDLK;LNTEVTTWR;RLKELVFQTEEDHK;TLTGDLSLR;TVHELDDAEDRAGMAETALNKLR;VIQQNVHK 8 9 0.97458 -3.6232 0 0 14.8017 8.77228 0 0 11.5796 0 11.0461 9.94116 10.7802 9.88533 Q9H6P5 TASP1_HUMAN Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta] TASP1 C20orf13 Homo sapiens (Human) epigenetic regulation of gene expression [GO:0040029]; positive regulation of DNA-templated transcription [GO:0045893]; protein maturation [GO:0051604]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; threonine-type endopeptidase activity [GO:0004298] FSLAAFK;LELAERVDTDFMQLKK 2 5.5 0.913 -0.38942 0 0 12.9758 10.2582 8.40207 8.21898 11.2494 0 0 0 0 0 Q9H6Q3 SLAP2_HUMAN Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) SLA2 C20orf156 SLAP2 Homo sapiens (Human) antigen receptor-mediated signaling pathway [GO:0050851]; B cell mediated immunity [GO:0019724]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] signaling adaptor activity [GO:0035591] LSRPASWDR 1 3.4 0.90904 -0.30111 0 0 0 0 0 0 0 10.1861 0 0 0 0 Q9H6Q4 CIAO3_HUMAN Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) CIAO3 NARFL PRN Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; intracellular oxygen homeostasis [GO:0032364]; iron-sulfur cluster assembly [GO:0016226]; regulation of gene expression [GO:0010468]; response to hypoxia [GO:0001666] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" AGSGVAK 1 1.5 0.77104 0.055008 13.5359 0 0 0 0 0 0 0 0 0 0 0 Q9H6R0 DHX33_HUMAN ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33) DHX33 DDX33 Homo sapiens (Human) positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of type I interferon production [GO:0032481]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA-binding transcription factor binding [GO:0140297]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; rDNA binding [GO:0000182]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AKKYNPDSGLEVLAVQR 1 2.4 0.84976 -0.076289 0 0 0 7.60511 0 0 0 0 0 0 0 0 Q9H6R3 ACSS3_HUMAN "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)" ACSS3 Homo sapiens (Human) ketone body biosynthetic process [GO:0046951] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetate-CoA ligase activity [GO:0003987]; ATP binding [GO:0005524]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; propionate-CoA ligase activity [GO:0050218] FKTLFVAGERCDVETLEWSK;KPSWLQCRK;LAGVLVK;SVPGYNVMILDDNMQK 4 7.6 0.034672 0.55354 0 0 0 0 5.85392 10.7874 0 9.25536 9.79476 0 0 8.93614 Q9H6R4 NOL6_HUMAN Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) NOL6 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409] condensed nuclear chromosome [GO:0000794]; CURI complex [GO:0032545]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456] RNA binding [GO:0003723] ASSTKGR;DTAASLRLERDTR;EILQDKDGLNQRYFR;ETEILFHSSLLRLQVEELLKEVR;LSMMLLDSR 5 5.8 0.97335 -2.9713 0 0 0 9.64232 0 0 11.1456 9.93724 0 11.2208 0 0 Q9H6R6 ZDHC6_HUMAN Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376) ZDHHC6 ZNF376 Homo sapiens (Human) positive regulation of mitochondrial fusion [GO:0010636]; protein palmitoylation [GO:0018345]; protein stearoylation [GO:0140438]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439] LSFGWNTVK;TSIESWIEEKAKDR 2 5.6 0.88103 -0.15322 0 6.03545 0 0 2.66907 0 0 8.66832 0 0 0 0 Q9H6S0 YTDC2_HUMAN 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) YTHDC2 Homo sapiens (Human) "germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; meiotic cell cycle [GO:0051321]; oocyte development [GO:0048599]; positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; spermatid development [GO:0007286]" endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein granule [GO:0035770] "3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]" AAMLCRK;EMSKTSGR;NGIPCRIFCTQPR;RAAMLCR;TERGNVFAVEAENREMSK;VLMKSPSPALHPPQKYK;YFIMKSSNLRNLEISQQK 7 5.5 0.97512 -2.3602 7.4266 0 0 5.83517 0 0 0 0 0 10.1782 0 10.7523 Q9H6S1 AZI2_HUMAN 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) AZI2 NAP1 TBKBP2 Homo sapiens (Human) defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; dendritic cell proliferation [GO:0044565]; mitotic cell cycle [GO:0000278]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; T cell activation [GO:0042110]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554] AKQTDPYQEDNLKSR;VLNEQLQSK 2 6.1 0.90912 -0.30851 0 11.444 0 0 10.4329 0 0 0 11.3807 0 0 0 Q9H6S3 ES8L2_HUMAN Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) EPS8L2 EPS8R2 PP13181 Homo sapiens (Human) positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; sensory perception of sound [GO:0007605] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] actin binding [GO:0003779]; cadherin binding [GO:0045296] EKIWTQEMLLQVNDQSLR;GHQEKIRQR;LLDIESQSAQTPGASR;QQSGSELEELMNKFHSMNQRR;VYSQLTMQKAFLEK 5 10.7 0.81445 -9.83E-05 0 4.28214 0 0 0 9.57956 9.63507 0 0 0 8.70366 0 Q9H6T0 ESRP2_HUMAN Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B) ESRP2 RBM35B PP7059 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; branching involved in salivary gland morphogenesis [GO:0060445]; epithelial cell proliferation [GO:0050673]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of RNA splicing [GO:0043484]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] HKHHMGVRYIEVYK;QVLHPEASRK;VLMGGTLGR 3 4.5 0.95417 -0.90506 0 0 0 9.46915 0 0 0 0 0 0 0 7.59582 Q9H6T3 RPAP3_HUMAN RNA polymerase II-associated protein 3 RPAP3 Homo sapiens (Human) protein stabilization [GO:0050821] cytosol [GO:0005829]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] AIECYTR;KNSSQDDLFPTSDTPRAK;QNAEELQDFMRDLENWEK;VLELEPNNFEATNELR;YEEAEKDCTQAILLDGSYSKAFAR 5 12.5 0.94436 -0.63303 0 0 0 0 0 7.29985 0 9.26831 0 7.65198 7.69467 0 Q9H6U6 BCAS3_HUMAN BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) BCAS3 Homo sapiens (Human) angiogenesis [GO:0001525]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; response to estrogen [GO:0043627]; response to starvation [GO:0042594] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; euchromatin [GO:0000791]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407] acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; phosphatidylinositol binding [GO:0035091] EKIVWVR;EQPNSNKACVRDGGR;GVSTVIDAASGTFDR;ILPAPQFGAQKCDNFAEK;VQDICFSHDCRWVVVSTLR 5 8 0.9748 -3.24 0 13.7975 0 0 9.98939 0 0 9.42561 0 12.1182 12.1581 10.3042 Q9H6W3 RIOX1_HUMAN "Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)" RIOX1 C14orf169 MAPJD NO66 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein demethylase activity [GO:0140457] MAALRTQTLPSENSEESR 1 2.8 0.92161 -0.44118 0 0 0 0 0 0 0 0 0 0 0 7.22949 Q9H6X2 ANTR1_HUMAN Anthrax toxin receptor 1 (Tumor endothelial marker 8) ANTXR1 ATR TEM8 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; substrate adhesion-dependent cell spreading [GO:0034446] cell surface [GO:0009986]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] GVGGIKRMEVR;LTEDREQIR;LTEDREQIRQGLEELQK;MPEQEYEFPEPRNLNNNMR 4 8.3 0.9759 -2.3001 0 0 0 0 0 0 9.27431 0 0 10.6985 9.84287 0 Q9H6X5 CS044_HUMAN Uncharacterized protein C19orf44 C19orf44 Homo sapiens (Human) LVSSPGR;TLQTPKQK 2 2.3 0.98048 -2.036 0 0 0 0 0 0 13.2986 0 0 0 0 11.0393 Q9H6Y2 WDR55_HUMAN WD repeat-containing protein 55 WDR55 Homo sapiens (Human) rRNA processing [GO:0006364] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AVAFSEDGQKLITVSKDK;EETGDDSD 2 6.8 0.92946 -0.46667 0 12.2449 2.11387 0 0 0 0 0 4.28629 0 0 0 Q9H6Y7 RN167_HUMAN E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) RNF167 RING105 LP2254 Homo sapiens (Human) "cellular response to leucine starvation [GO:1990253]; lysosome localization [GO:0032418]; negative regulation of cell cycle [GO:0045786]; negative regulation of TORC1 signaling [GO:1904262]; organelle localization [GO:0051640]; positive regulation of TORC1 signaling [GO:1904263]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of synaptic transmission, glutamatergic [GO:0051966]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] KTCPICKQPVHR;VLPCAHAYHSR 2 6.6 0.848 -0.076875 0 0 0 7.60415 0 0 0 0 0 0 5.83724 0 Q9H6Z4 RANB3_HUMAN Ran-binding protein 3 (RanBP3) RANBP3 Homo sapiens (Human) protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] R-SMAD binding [GO:0070412]; small GTPase binding [GO:0031267] ASEKSIRITAMDTEDQGVK;SRVEQEQEAK 2 5.1 0.90091 -0.25957 0 0 0 0 0 0 7.87061 0 0 0 8.1498 0 Q9H706 GARE1_HUMAN GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) GAREM1 C18orf11 FAM59A GAREM Homo sapiens (Human) cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] plasma membrane [GO:0005886] proline-rich region binding [GO:0070064] LLEQDRDIK;LSKLQVKK;QSTSCPALPPR 3 3.2 0.98033 -1.6498 10.59 0 11.426 0 0 0 0 0 0 0 0 0 Q9H707 ZN552_HUMAN Zinc finger protein 552 ZNF552 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HHQRVHKR;QISSLRHHQR;SGLLQQEATHTGK 3 6.6 0.81231 -0.01176 11.6026 0 0 0 8.15031 0 0 0 0 8.71401 0 10.9882 Q9H714 PACER_HUMAN Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) RUBCNL C13orf18 KIAA0226L Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] CDVDEFVILELGDFNDITETCSCSCSSSK;ELDRVKEIQEQLFHIK;ENAHFYVADMIISAMEKMK;IKKGLLAPLLK;LLNTDHPPCQLDIR 5 13.4 0.3045 0.2504 0 7.35218 0 0 0 0 5.80828 8.47731 0 0 0 0 Q9H714 PACER_HUMAN Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) RUBCNL C13orf18 KIAA0226L Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] KPRSWTE;LLNTDHPPCQLDIR 2 14.3 0.90486 -0.26959 0 8.17053 0 0 0 6.94111 0 0 0 0 7.26313 0 Q9H714 PACER_HUMAN Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) RUBCNL C13orf18 KIAA0226L Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] CDVDEFVILELGDFNDITETCSCSCSSSK;ELDRVKEIQEQLFHIK;ENAHFYVADMIISAMEKMK;FANSCVK;LLNTDHPPCQLDIR 5 13.4 0.98097 -1.7002 0 0 0 0 0 0 11.5254 0 8.14563 12.4055 0 8.32143 Q9H720 PG2IP_HUMAN PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog) CWH43 PGAP2IP Homo sapiens (Human) brain development [GO:0007420]; cell adhesion [GO:0007155]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; GPI anchor biosynthetic process [GO:0006506]; membrane protein ectodomain proteolysis [GO:0006509]; neuromuscular process controlling balance [GO:0050885]; peptide secretion [GO:0002790]; protein import into nucleus [GO:0006606]; protein localization to extracellular region [GO:0071692]; protein N-linked glycosylation [GO:0006487]; protein targeting to membrane [GO:0006612]; regulation of intracellular signal transduction [GO:1902531]; regulation of protein import into nucleus [GO:0042306]; regulation of protein processing [GO:0070613]; walking behavior [GO:0090659] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] IWYTSLNPIWSYQMSNK 1 2.4 0.65793 0.16934 5.79937 0 0 0 0 0 0 0 0 0 0 0 Q9H756 LRC19_HUMAN Leucine-rich repeat-containing protein 19 LRRC19 Homo sapiens (Human) host-mediated regulation of intestinal microbiota composition [GO:0048874]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; toll-like receptor signaling pathway [GO:0002224] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] QLYLCQNKIEQLNADVFVPLRSLK 1 6.5 0.96344 -1.1126 0 0 0 0 9.75203 0 0 0 0 0 0 0 Q9H765 ASB8_HUMAN Ankyrin repeat and SOCS box protein 8 (ASB-8) ASB8 PP14212 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] AVGHFELR;TLARYAVRR;VINLIGQTPISRLVALLVRGLGTEK 3 14.6 0.98052 -1.6813 0 0 8.68797 0 0 0 5.50779 0 0 0 0 10.0102 Q9H773 DCTP1_HUMAN dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) DCTPP1 XTP3TPA CDA03 Homo sapiens (Human) dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556] LHAEFAAER;TDGEPGPQGWSPRER 2 14.1 0.95721 -1.0225 6.35324 0 8.0289 8.61246 0 0 0 0 0 0 0 0 Q9H777 RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) ELAC1 D29 Homo sapiens (Human) rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; tRNA-specific ribonuclease activity [GO:0004549] AFRLFHRIPSFGFSVVEK;CEGECWLFDCGEGTQTQLMK;IPSFGFSVVEK;LKDLGVPPGPAYGK 4 14.3 0.91745 -0.42113 0 0 0 0 0 12.7837 0 0 0 0 15.2571 0 Q9H788 SH24A_HUMAN SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) SH2D4A PPP1R38 SH2A Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829] phosphatase binding [GO:0019902] EDSEWQASLR;ELLLYPCGQQDQLPDYLELFE;LSLGAQKGR;MKAYAFHQK 4 10.8 0.972 -2.6993 0 6.27577 0 0 0 0 2.95082 0 0 0 12.1581 0 Q9H792 PEAK1_HUMAN Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) PEAK1 KIAA2002 Homo sapiens (Human) cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; protein autophosphorylation [GO:0046777]; regulation of cell motility [GO:2000145]; regulation of focal adhesion assembly [GO:0051893]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672] AAMIPPK;CEDLFMAGQK;GNETNSR;QPKGAVDDAIAFGGK;SSAIRYQEVWTSSTSPRQK 5 3.3 0.97635 -2.1845 0 0 0 7.80458 4.5373 0 0 0 0 15.6945 9.2431 0 Q9H799 CPLN1_HUMAN Ciliogenesis and planar polarity effector 1 (Protein JBTS17) CPLANE1 C5orf42 JBTS17 Homo sapiens (Human) cilium assembly [GO:0060271] ciliary transition zone [GO:0035869]; membrane [GO:0016020] AFPYPEDVR;DDSEETDR;GQEHDPFCPRSNPLYMTSREIR;KTQLIPLENLIAFKQSQQK;LLCDSGITESSSEYSPVIR;LTHNLFEQGDAGHLQLLKVK;MAKYLNELAEKR;QKVSGILQR;SIYKIQDDTR;VKYMSKPSYIHKR 10 4.4 0.97329 -2.9364 8.78908 7.10706 0 0 0 8.17138 13.3483 0 0 0 5.59365 11.7527 Q9H799 CPLN1_HUMAN Ciliogenesis and planar polarity effector 1 (Protein JBTS17) CPLANE1 C5orf42 JBTS17 Homo sapiens (Human) cilium assembly [GO:0060271] ciliary transition zone [GO:0035869]; membrane [GO:0016020] AFPYPEDVR;DDSEETDR;KTQLIPLENLIAFKQSQQK;LLCDSGITESSSEYSPVIR;LTHNLFEQGDAGHLQLLKVK;QKVSGILQR;SIYKIQDDTR;SQEVTPACLDGKSLR 8 3.7 0.91586 -0.39705 0 0 0 0 0 0 0 0 10.3773 0 0 0 Q9H7B2 RPF2_HUMAN Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) RPF2 BXDC1 Homo sapiens (Human) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]" chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] EPKLNENIK;VLKDVYALKKPYGVLYK 2 8.5 0.94469 -0.64459 0 0 0 0 0 0 0 10.2911 0 0 0 0 Q9H7B4 SMYD3_HUMAN Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1) SMYD3 ZMYND1 ZNFN3A1 Homo sapiens (Human) cellular response to dexamethasone stimulus [GO:0071549]; establishment of protein localization [GO:0045184]; methylation [GO:0032259]; myotube cell development [GO:0014904]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H4 methyltransferase activity [GO:0140939]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162] DQYCFECDCFR;GVQVMKVGK 2 4.7 0.96396 -1.1913 0 6.31288 5.008 0 3.7939 0 0 0 5.70623 0 0 0 Q9H7C4 SYNCI_HUMAN Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1) SYNC SYNC1 Homo sapiens (Human) intermediate filament-based process [GO:0045103] cytosol [GO:0005829]; intermediate filament [GO:0005882]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; Z disc [GO:0030018] LSLAEELSTYKAMLLPK;LVKQKLFK;NGVQLQQQKNKEMEQLR 3 8.7 0.96296 -1.1043 0 0 0 0 0 7.89124 0 0 0 0 0 0 Q9H7C9 AAMDC_HUMAN Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein) AAMDC C11orf67 PTD015 Homo sapiens (Human) positive regulation of fat cell differentiation [GO:0045600] cytoplasm [GO:0005737] DGIQGAQLDLNC;GMSEALK;VWPGGSR 3 29.5 0.93766 -0.57608 6.31712 0 10.7655 0 0 0 0 0 0 0 8.99053 0 Q9H7D0 DOCK5_HUMAN Dedicator of cytokinesis protein 5 DOCK5 Homo sapiens (Human) bone remodeling [GO:0046849]; cell migration [GO:0016477]; myoblast fusion [GO:0007520]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; podosome assembly [GO:0071800]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; Rac protein signal transduction [GO:0016601] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DWSLSKSQVIAEKAPEPDLMSPTR;ELKEKVEK;GEKDPDNEFATMWIER;GIFPETYIHLK;IQEEKSILQNLDLR;LMEVDGGEIVK;LSSCFRELK;LSSCFRELKEK;LVFDPVELSVLFCKFIQSIPDNQLVR;QDIIDFLMETFIMFKDLIGK;VEDLSLREENSENR;VGHMELK;VLYLRFYGQSKDGDEFNNSIR;VSLVCQIVRVGHMELK;WGSNGMPKEIEK 15 10.6 0.97577 -4.3251 5.62618 11.7925 12.2862 0 0 10.1037 11.8647 12.5111 12.0429 9.86603 7.39154 11.721 Q9H7D7 WDR26_HUMAN WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) WDR26 CDW2 MIP2 PRO0852 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] IWGPAPFIDHQNIEEECSSMDS;QAVELQR;QAVELQRDRCLYHNTK 3 5.7 0.92105 -0.43998 0 0 0 0 0 0 0 0 0 4.71831 5.42092 0 Q9H7E2 TDRD3_HUMAN Tudor domain-containing protein 3 TDRD3 Homo sapiens (Human) chromatin organization [GO:0006325]; DNA topological change [GO:0006265] cytosol [GO:0005829]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] ILESSIPMEYAK;RESQTSIPDYFYDRK;SNLNMNAAGNRNR 3 6.1 0.94179 -0.5962 0 0 0 0 9.67719 0 0 0 8.25758 0 0 10.7029 Q9H7F0 AT133_HUMAN Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16) ATP13A3 AFURS1 Homo sapiens (Human) intracellular calcium ion homeostasis [GO:0006874]; polyamine transmembrane transport [GO:1902047] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038] ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]; polyamine transmembrane transporter activity [GO:0015203] IGIFCISPQR;LVHDSLEDLQMTRYHFAMNGK;QETPAVLEDLHK;VPSVFKLLIK 4 4.3 0.95705 -0.84858 7.86567 0 0 0 0 6.17491 0 10.7085 0 10.8901 0 0 Q9H7J1 PPR3E_HUMAN Protein phosphatase 1 regulatory subunit 3E PPP1R3E Homo sapiens (Human) glycogen metabolic process [GO:0005977]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979] glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164] [phosphorylase] phosphatase activity [GO:0050196]; glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157] ERPPGTDIPRNLSFIAALTER;WSADGWRSQR 2 11.1 0.98051 -1.6769 0 0 0 0 0 0 0 9.6764 0 0 10.0836 0 Q9H7L2 KI3X1_HUMAN Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 (Leukocyte receptor cluster member 12) KIR3DX1 KIR3DL0 LENG12 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; immune response-regulating signaling pathway [GO:0002764] extracellular region [GO:0005576]; plasma membrane [GO:0005886] VTLSCHSHLR 1 2.8 0.8972 -0.24012 0 0 0 9.75716 0 0 0 0 0 0 0 0 Q9H7L9 SDS3_HUMAN Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog) SUDS3 SAP45 SDS3 Homo sapiens (Human) apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826] EFEDKKVELK;QLQQLQEGTLQEYQKRMK 2 8.5 0.95397 -0.9155 0 0 7.99164 0 0 0 0 0 0 0 8.22304 0 Q9H7M6 ZSWM4_HUMAN Zinc finger SWIM domain-containing protein 4 ZSWIM4 Homo sapiens (Human) Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] DAGAGAARGR;IVFWSFPR 2 1.8 0.97463 -1.4285 11.8338 0 0 0 0 0 0 0 0 0 8.5575 0 Q9H7M9 VISTA_HUMAN V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) VSIR C10orf54 SISP1 VISTA PP2135 UNQ730/PRO1412 Homo sapiens (Human) "negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of immune response [GO:0050776]; zymogen activation [GO:0031638]" plasma membrane [GO:0005886] endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802] TWYRSSR 1 2.3 0.90437 -0.26801 0 0 0 0 0 0 0 0 0 0 9.44025 0 Q9H7N4 SFR19_HUMAN "Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)" SCAF1 SFRS19 SRA1 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122] AYVQRYRYFR 1 0.8 0.96499 -1.1632 0 0 0 10.5023 0 10.1005 0 0 0 0 0 0 Q9H7P9 PKHG2_HUMAN Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) PLEKHG2 Homo sapiens (Human) regulation of actin filament polymerization [GO:0030833] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AGAPSSERTASR;ASANAPR;EIVETERAYVRDLR;GGGGGGPR;GLEYTYK;HSLPLQSFLLKPVQRILKYHLLLQELGK 6 5.5 0.91709 -0.42196 0 0 0 9.55294 0 0 9.11288 9.03309 6.97682 0 0 10.4627 Q9H7R0 ZN442_HUMAN Zinc finger protein 442 ZNF442 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFPIYSSYLRHER;DVMWETIR;MIVFGGEDR;MIVFGGEDRSDLFLPDSQTNEERK 4 7.2 0.96421 -1.1979 0 0 0 6.63257 0 0 8.21956 7.51175 8.29779 0 0 0 Q9H7R5 ZN665_HUMAN Zinc finger protein 665 (Zinc finger protein 160-like) ZNF665 ZFP160L Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DDEGNYK;IYEYNQVEKSPNNR;NTYDFECQWK;TLYRDVMLENYR 4 6.3 0.9804 -1.6688 8.9718 0 0 9.11832 0 0 0 0 0 8.08375 0 0 Q9H7T0 CTSRB_HUMAN Cation channel sperm-associated auxiliary subunit beta (CatSper-beta) CATSPERB C14orf161 Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; cilium [GO:0005929]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] EHFEVDYVTVTFERNR;GFLSSVIAEMK;ITLHHGLNIYATEGTLLDVIR;WIRRNQEK 4 5 0.98031 -1.8614 8.91967 0 0 0 0 9.4028 0 0 0 8.55109 12.1307 0 Q9H7T9 AUNIP_HUMAN Aurora kinase A- and ninein-interacting protein (AIBp) AUNIP C1orf135 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; spindle organization [GO:0007051] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; spindle pole [GO:0000922] damaged DNA binding [GO:0003684] MLTLLPGERKANIYFTQR 1 5 0.52071 0.18709 0 0 0 7.93964 0 0 0 0 0 0 0 0 Q9H7U1 CCSE2_HUMAN Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) CCSER2 FAM190B KIAA1128 NPD012 Homo sapiens (Human) microtubule bundle formation [GO:0001578] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630] microtubule binding [GO:0008017] IQLLELQLATQHICHQKCK;VPTQGMFDK;VYKNEDLLNEIK 3 4.8 0.95575 -0.98664 0 0 0 0 0 0 8.21563 11.5234 7.49929 0 0 0 Q9H7V2 SYNG1_HUMAN Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 C20orf39 TMEM90B Homo sapiens (Human) intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; regulation of postsynapse assembly [GO:0150052]; synaptic vesicle clustering [GO:0097091] cell body [GO:0044297]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672] glutamate receptor binding [GO:0035254]; protein homodimerization activity [GO:0042803] AVAKGDLHQASTSSR 1 5.8 0.88246 -0.16526 0 0 0 0 0 0 0 0 0 9.09648 0 0 Q9H7X2 RDD1_HUMAN Required for drug-induced death protein 1 C1orf115 RDD1 Homo sapiens (Human) regulation of response to drug [GO:2001023] 9+0 non-motile cilium [GO:0097731]; membrane [GO:0016020] YEPLEEPAPSEQPR 1 9.9 0.79918 0.014684 0 0 0 0 0 0 0 0 0 0 0 5.89208 Q9H7Y0 DIK2B_HUMAN Divergent protein kinase domain 2B (Deleted in autism-related protein 1) DIPK2B CXorf36 DIA1R UNQ1862/PRO3743 Homo sapiens (Human) extracellular region [GO:0005576] DASAVGVIDKQEGSQEANR;IWRPVEIFRLVSK;QEGSQEANRAGENK 3 8.5 0.94491 -0.64409 7.18943 0 0 0 0 3.84077 0 0 0 6.6499 6.97533 0 Q9H7Y0 DIK2B_HUMAN Divergent protein kinase domain 2B (Deleted in autism-related protein 1) DIPK2B CXorf36 DIA1R UNQ1862/PRO3743 Homo sapiens (Human) extracellular region [GO:0005576] IWRPVEIFRLVSK;LTPDLVQDCHQGQR;LTPDLVQDCHQGQRELK 3 16.5 0.88159 -0.16065 11.1306 0 0 0 0 0 10.5259 9.69293 0 0 0 10.4373 Q9H7Z3 NRDE2_HUMAN Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) NRDE2 C14orf102 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of RNA catabolic process [GO:1902369]; positive regulation of RNA export from nucleus [GO:0046833]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GVGGSKK;KPDPANWEYK;QAGHSEK;SYVQIQNKSHSASK;TDKKPDPANWEYK 5 3.5 0.9668 -1.288 0 11.148 0 8.12856 0 0 0 0 9.61032 11.0429 0 0 Q9H7Z6 KAT8_HUMAN "Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-)" KAT8 MOF MYST1 PP7073 Homo sapiens (Human) dosage compensation by inactivation of X chromosome [GO:0009048]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of type I interferon production [GO:0032480]; neurogenesis [GO:0022008]; oogenesis [GO:0048477]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of skeletal muscle satellite cell differentiation [GO:1902726]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-embryonic hemopoiesis [GO:0035166]; regulation of autophagy [GO:0010506]; regulation of mitochondrial transcription [GO:1903108]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K16 propionyltransferase activity [GO:0141002]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; promoter-specific chromatin binding [GO:1990841]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DAVQKNSEK;GQHVICVTPKLVEEHLK;LALTKTVKDAVQK;RGYGKFLIAFSYELSK;TVKDAVQK;YMKYEKSYR 6 12.9 0.97541 -3.5856 0 0 10.3451 0 7.271 0 11.3474 0 0 6.46573 0 0 Q9H7Z7 PGES2_HUMAN Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] PTGES2 C9orf15 PGES2 Homo sapiens (Human) cyclooxygenase pathway [GO:0019371]; lipid metabolic process [GO:0006629]; positive regulation of DNA-templated transcription [GO:0045893]; secretion [GO:0046903] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; DNA binding [GO:0003677]; glutathione binding [GO:0043295]; heme binding [GO:0020037]; lyase activity [GO:0016829]; prostaglandin-E synthase activity [GO:0050220] AQDLHAER;LQLTLYQYKTCPFCSK;TEEMKWR 3 8.2 0.98101 -2.0339 0 0 0 0 10.5393 0 8.6291 0 0 0 0 0 Q9H814 PHAX_HUMAN Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) PHAX RNUXA Homo sapiens (Human) protein transport [GO:0015031]; RNA stabilization [GO:0043489]; snRNA export from nucleus [GO:0006408] Cajal body [GO:0015030]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA cap binding complex binding [GO:0140262]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643] DIFYIENQK;DIFYIENQKEYENKK 2 3.8 0.98067 -1.7797 0 0 13.0251 0 0 0 0 0 0 0 0 0 Q9H816 DCR1B_HUMAN 5' exonuclease Apollo (EC 3.1.-.-) (Beta-lactamase DCLRE1B) (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B) DCLRE1B SNM1B Homo sapiens (Human) double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; protection from non-homologous end joining at telomere [GO:0031848]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; telomeric 3' overhang formation [GO:0031860]; telomeric loop formation [GO:0031627] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]" 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] MNGVLIPHTPIAVDFWSLR 1 3.6 0.78445 0.028116 0 0 0 5.38021 0 0 0 0 7.65628 0 0 0 Q9H819 DJC18_HUMAN DnaJ homolog subfamily C member 18 DNAJC18 Homo sapiens (Human) cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085] endoplasmic reticulum membrane [GO:0005789] Hsp70 protein binding [GO:0030544] YPEDTPPESHDPCGCCNCMK 1 5.6 0.78363 0.025586 0 0 0 0 0 0 6.83036 0 0 0 0 0 Q9H825 METL8_HUMAN "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-)" METTL8 Homo sapiens (Human) mitochondrial tRNA modification [GO:0070900]; mRNA metabolic process [GO:0016071]; positive regulation of mitochondrial translation [GO:0070131]; tRNA C3-cytosine methylation [GO:0106217] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] mRNA methyltransferase activity [GO:0008174]; tRNA (cytidine-3-)-methyltransferase activity [GO:0052735] MNMIWRNSISCLR 1 4.5 0.92214 -0.4454 0 0 0 0 0 0 0 10.1124 0 0 0 0 Q9H841 NPAL2_HUMAN NIPA-like protein 2 NIPAL2 NPAL2 Homo sapiens (Human) magnesium ion transport [GO:0015693] membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] KGMKHMVILLTLVAILASLTVISVK 1 6.8 0.66274 0.16893 0 0 0 0 0 0 0 0 5.46601 0 0 0 Q9H845 ACAD9_HUMAN "Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-)" ACAD9 Homo sapiens (Human) long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid metabolic process [GO:0051791]; mitochondrial respiratory chain complex I assembly [GO:0032981] dendrite [GO:0030425]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991] ELFLGKIKK;GLVVSTANRR;IDQEGKIPDETLEKLK;LSEFGLIQEK 4 7.2 0.975 -3.2563 0 0 0 0 14.7847 0 0 11.1864 0 0 0 0 Q9H857 NT5D2_HUMAN 5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-) NT5DC2 Homo sapiens (Human) negative regulation of catecholamine metabolic process [GO:0045914]; negative regulation of dopamine biosynthetic process [GO:1903180]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of peptidyl-serine phosphorylation [GO:0033137] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] GLHYDIQK;GSLQWDRITR;LTEWRGPR;MQTYQDAESRQVLAAWMKER 4 8.8 0.97443 -3.5043 0 0 0 0 0 10.4015 9.57975 0 0 0 7.19111 0 Q9H867 MT21D_HUMAN Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) VCPKMT C14orf138 METTL21D Homo sapiens (Human) negative regulation of ATP-dependent activity [GO:0032780]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] ATPase binding [GO:0051117]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279] IPLEKHDEEYR 1 4.8 0.92182 -0.44532 0 0 0 10.2951 0 0 0 0 0 0 0 0 Q9H869 YYAP1_HUMAN YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) YY1AP1 HCCA2 YY1AP Homo sapiens (Human) cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] ELFEQLKMK;GVVLKLKPVADRFPK;ILFTKAEDNKYLLTCK;MGFSNMEDDGPEEEER;QLTVRIKNLNMNR;YLLTCKTARQLTVR 6 10 0.95554 -0.81306 0 0 0 0 8.20721 0 11.0345 0 6.70432 5.68513 0 9.70504 Q9H8E8 CSR2B_HUMAN Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) KAT14 CSRP2BP Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase activity [GO:0004402]; LIM domain binding [GO:0030274] LAMYNLSLEGSGR;LSASTLK;LVHNKPPTMKPEGEK 3 5.4 0.87647 -0.13329 0 0 11.5713 0 3.96947 0 0 0 0 6.09005 0 0 Q9H8G1 ZN430_HUMAN Zinc finger protein 430 ZNF430 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; substantia nigra development [GO:0021762] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFYRFSYLTKHK;ENSYQCEECGK;HKIIHTGEKFYK;SFCMLLHLTQHKRIHIR 4 8.8 0.97957 -1.8491 0 7.71733 0 0 0 10.4735 10.3091 0 0 0 0 0 Q9H8G2 CAAP1_HUMAN Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) CAAP1 C9orf82 CAAP Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; regulation of apoptotic process [GO:0042981] KLCQEQLELLSEKK 1 3.9 0.84877 -0.070125 10.927 0 0 0 0 0 0 0 0 0 0 0 Q9H8H0 NOL11_HUMAN Nucleolar protein 11 NOL11 L14 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; t-UTP complex [GO:0034455] RNA binding [GO:0003723] RLLINLYKLVK 1 1.5 0.87025 -0.096403 0 0 0 0 0 0 0 0 0 9.8595 0 0 Q9H8H2 DDX31_HUMAN ATP-dependent DNA helicase DDX31 (EC 5.6.2.-) (DEAD box protein 31) (Helicain) (Probable ATP-dependent RNA helicase DDX31) (EC 3.6.4.13) DDX31 Homo sapiens (Human) ribosome biogenesis [GO:0042254] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; isomerase activity [GO:0016853]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ATVLQTVFEDYVHSSERR;CKFEEDQK;ELKHIFHVR;GGGAGSSR;GVQRDSK;SHAVGPQEIR;SHAVGPQEIRER 7 7.3 0.95824 -1.0123 8.09556 12.4977 0 0 0 0 0 7.95449 4.82609 7.02625 10.0844 0 Q9H8J5 MANS1_HUMAN MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein) MANSC1 LOH12CR3 UNQ316/PRO361 Homo sapiens (Human) Golgi apparatus [GO:0005794]; membrane [GO:0016020] YSRLDYLINGIYVDI 1 3.5 0.8137 -0.010916 0 0 0 0 0 0 11.1602 0 0 0 0 0 Q9H8K7 PAAT_HUMAN ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) PAAT C10orf88 Homo sapiens (Human) cytoplasm [GO:0005737]; mitochondrion [GO:0005739] ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802] ILSKNMELMEK 1 2.5 0.77865 0.038563 0 0 0 11.832 0 0 0 0 0 0 11.8916 0 Q9H8L6 MMRN2_HUMAN Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of morphogenesis of an epithelium [GO:1905332] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multimerin complex [GO:1990972] receptor ligand activity [GO:0048018] EEELQYTLEDMRATLTR;VLTSLAWR;YVKDCNCQKLYLDLDVIR 3 4.5 0.95672 -0.8468 0 10.5417 0 0 7.83232 0 0 0 0 0 0 0 Q9H8M1 CQ10B_HUMAN "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial" COQ10B Homo sapiens (Human) cellular respiration [GO:0045333] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ubiquinone binding [GO:0048039] ITAPLINKRK;SATAAGAQAPVR;SATAAGAQAPVRNGR 3 10.5 0.97874 -2.0756 0 0 0 7.84071 0 0 7.83889 0 0 0 0 0 Q9H8M2 BRD9_HUMAN Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) BRD9 UNQ3040/PRO9856 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] lysine-acetylated histone binding [GO:0070577]; nucleic acid binding [GO:0003676] INRFLPGGKVVLCGHR;LMCDNAMTYNRPDTVYYKLAK 2 15.9 0.84906 -0.071012 0 0 0 0 0 0 0 0 0 10.3922 0 0 Q9H8M2 BRD9_HUMAN Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) BRD9 UNQ3040/PRO9856 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] lysine-acetylated histone binding [GO:0070577]; nucleic acid binding [GO:0003676] DAGSYSK;LMCDNAMTYNRPDTVYYKLAK;SIWTMRK;SIWTMRKEGSER 4 7.4 0.93395 -0.51532 6.41031 2.20355 0 0 6.85636 7.06437 8.19712 8.54059 0 6.99797 6.91433 8.73846 Q9H8Q6 HEAS1_HUMAN Putative uncharacterized protein encoded by HEXA-AS1 (HEXA antisense RNA 1) (HEXA antisense gene protein 1) HEXA-AS1 C15orf34 Homo sapiens (Human) SRNLFSEQLK 1 7.2 0.94373 -0.6234 0 0 0 0 0 0 0 0 0 8.91976 0 0 Q9H8S5 CCNP_HUMAN Cyclin-P (Cyclin N-terminal domain-containing protein 2) CCNP CNTD2 Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] LLDGAGSR;LLDGAGSRLQPELYR;VRLHRLQLLGVACLFVACK 3 11.1 0.97733 -2.2338 0 0 0 0 0 0 0 0 0 11.4528 0 9.42796 Q9H8V3 ECT2_HUMAN Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) ECT2 Homo sapiens (Human) "activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; bicellular tight junction assembly [GO:0070830]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]" bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] EVMTHINEDKR;LPSVALLLNDLK;VILVQEAGKQEELIK;VILVQEAGKQEELIKALK 4 4.5 0.92913 -0.47034 13.4649 11.8405 0 0 0 0 0 0 0 7.25191 11.4232 0 Q9H8V8 YD018_HUMAN Putative uncharacterized protein FLJ13197 Homo sapiens (Human) GAAGTRVR 1 5.9 0.91389 -0.33804 0 0 0 0 8.02625 0 0 0 0 0 0 0 Q9H8W3 F204A_HUMAN Protein FAM204A FAM204A C10orf84 Homo sapiens (Human) ELTQYFGVNDRFDPPVKR;KEVENSQAAR;LAWGFEAKK 3 15.9 0.71263 0.1468 0 7.54272 0 0 9.86217 0 0 11.9723 0 0 0 0 Q9H8W5 TRI45_HUMAN E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) bone development [GO:0060348]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CACGGTMPGGYLGCGHGHK;LLKQLEDIRAQK;VQYSTRPGVNDK 3 7.4 0.95327 -0.72715 0 0 0 0 0 0 0 0 11.0522 0 4.26828 0 Q9H8X2 IPPK_HUMAN "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)" IPPK C9orf12 Homo sapiens (Human) inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity [GO:0035299]; molecular adaptor activity [GO:0060090]" AVIRELVHVITRVLLSGSDK;CQGKNTPER;DNAVMSTR;IQSERPESR;VERYLEEFPEER;VLLSGSDKGR 6 12.2 0.97333 -2.5672 0 6.43042 0 12.6252 12.3473 7.84668 8.26758 0 0 0 0 6.75449 Q9H8X9 ZDH11_HUMAN Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399) ZDHHC11 ZNF399 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of defense response to virus by host [GO:0002230]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] protein-cysteine S-palmitoyltransferase activity [GO:0019706]; signaling adaptor activity [GO:0035591] VFVPRVR 1 4.9 0.67572 0.16608 0 0 0 0 8.52297 8.54032 0 0 0 2.75992 0 0 Q9H8Y1 VRTN_HUMAN Vertnin VRTN C14orf115 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565] ARTVVEMLLHR;GEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHR 2 5.1 0.97604 -1.4761 11.6893 0 0 0 0 0 0 0 0 0 5.70135 0 Q9H8Y5 ANKZ1_HUMAN tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) ANKZF1 ZNF744 Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; ERAD pathway [GO:0036503]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737]; membrane [GO:0016020] "catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]" AGDVGVLK;STRNEFR 2 2.1 0.9529 -0.73599 0 10.546 8.45224 0 0 0 0 0 0 0 0 0 Q9H900 ZWILC_HUMAN Protein zwilch homolog (hZwilch) ZWILCH Homo sapiens (Human) cell division [GO:0051301]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988] cytosol [GO:0005829]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; RZZ complex [GO:1990423] HHLSTVTSKGFAQYELFK;VESGEPR 2 4.2 0.95546 -0.82652 0 0 0 0 0 0 0 0 0 11.6783 0 0 Q9H902 REEP1_HUMAN Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) REEP1 C2orf23 SPG31 Homo sapiens (Human) endoplasmic reticulum tubular network organization [GO:0071786]; protein insertion into membrane [GO:0051205] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966] microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849] ASGKHGQPK;IAFVAWLLSPYTKGSSLLYR 2 14.4 0.91015 -0.28121 0 0 0 0 0 7.73003 0 0 9.70606 0 10.0494 0 Q9H902 REEP1_HUMAN Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) REEP1 C2orf23 SPG31 Homo sapiens (Human) endoplasmic reticulum tubular network organization [GO:0071786]; protein insertion into membrane [GO:0051205] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966] microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849] ILRSRFR 1 4.9 0.97803 -1.5119 0 0 0 0 0 0 0 3.59216 0 0 8.04018 0 Q9H903 MTD2L_HUMAN "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" MTHFD2L Homo sapiens (Human) 10-formyltetrahydrofolate metabolic process [GO:0009256]; folic acid metabolic process [GO:0046655]; L-histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] NVVVAGRSK;TVPVRGFSLLRGR 2 6.3 0.96168 -1.0707 0 0 0 12.669 12.4519 0 0 0 0 13.715 0 12.824 Q9H910 JUPI2_HUMAN Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) JPT2 C16orf34 HN1L L11 Homo sapiens (Human) endocytosis involved in viral entry into host cell [GO:0075509]; regulation of calcium-mediated signaling [GO:0050848] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] TSDIFGSPVTATSR;VLNPPGGK 2 11.6 0.84042 -0.04825 10.006 0 0 0 0 8.32724 0 0 8.34119 0 0 0 Q9H930 SP14L_HUMAN Nuclear body protein SP140-like protein SP140L Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" ASYKYKDFGQMGLR;GILHKEK;LEAEFEK;MFEDSEDSCR;WFTPMEFEIK 5 8.3 0.97256 -2.6008 0 7.72567 0 12.639 7.34784 10.4057 0 0 0 0 15.6833 0 Q9H939 PPIP2_HUMAN Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2) PSTPIP2 Homo sapiens (Human) actin filament polymerization [GO:0030041] actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015] EFEDFLK;GPLPIPK;TAVEDSDKAYMLHIGTLDKVR 3 10.5 0.93597 -0.52691 0 0 10.3167 0 0 0 9.23213 0 0 0 0 0 Q9H963 ZN702_HUMAN Putative zinc finger protein 702 ZNF702P ZNF702 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] SSLVIHKAIHTGEKPHK;YLAYHHR 2 18.6 0.95609 -0.8454 0 0 0 0 6.92612 0 0 0 0 0 0 0 Q9H967 WDR76_HUMAN WD repeat-containing protein 76 WDR76 Homo sapiens (Human) DNA damage response [GO:0006974]; regulation of DNA damage checkpoint [GO:2000001] heterochromatin [GO:0000792]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] DNA binding [GO:0003677]; enzyme binding [GO:0019899] DTHIYDARRLNSR;SGAAAEK;YILAGGNSSGKIHVFMNEK 3 6.2 0.52354 0.18673 0 0 9.43854 0 11.1923 0 0 9.37278 0 0 0 0 Q9H972 CN093_HUMAN Uncharacterized protein C14orf93 C14orf93 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of gene expression [GO:0010628] extracellular region [GO:0005576] RNA binding [GO:0003723] CCCCACK;LTELCYHLDANSKHGTK;SSWNISVVKFLLEKLK 3 7.4 0.97407 -1.4193 0 0 0 8.21057 3.74749 0 0 0 0 0 0 9.48212 Q9H974 QTRT2_HUMAN Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1) QTRT2 QTRTD1 Homo sapiens (Human) tRNA-guanine transglycosylation [GO:0101030] cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234]; tRNA-guanine transglycosylase complex [GO:0120507] metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] GCSCYCCK 1 1.9 0.74544 0.10231 0 0 0 0 0 0 3.76426 0 0 0 0 0 Q9H981 ARP8_HUMAN Actin-related protein 8 (hArp8) (INO80 complex subunit N) ACTR8 ARP8 INO80N Homo sapiens (Human) cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524] TSVCCVEDGVSHR 1 2.1 0.28208 0.25374 0 4.98213 0 0 0 0 7.91648 0 0 0 0 0 Q9H987 SYP2L_HUMAN Synaptopodin 2-like protein SYNPO2L Homo sapiens (Human) heart morphogenesis [GO:0003007]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; sarcomere organization [GO:0045214] actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; Z disc [GO:0030018] actin binding [GO:0003779] HQPYQLK;ISVPAAR 2 1.4 0.95611 -0.83839 0 0 0 0 0 0 0 9.44404 0 10.9226 0 0 Q9H992 MARH7_HUMAN E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) MARCHF7 AXOT MARCH7 RNF177 Homo sapiens (Human) "negative regulation of cilium assembly [GO:1902018]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein polyubiquitination [GO:1902916]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; regulation of tolerance induction [GO:0002643]" centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] MDM2/MDM4 family protein binding [GO:0097371]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ILTASQSR 1 1.1 0.9359 -0.52742 0 0 0 0 0 0 0 0 0 10.7139 0 0 Q9H999 PANK3_HUMAN Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) PANK3 Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310] cytosol [GO:0005829]; nucleus [GO:0005634] acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; vitamin binding [GO:0019842] MKIKDAK;SIRKYLTSNVAYGSTGIR 2 6.8 0.82538 -0.020127 0 0 7.45171 0 0 0 0 0 0 0 0 0 Q9H9A5 CNO10_HUMAN CCR4-NOT transcription complex subunit 10 CNOT10 Homo sapiens (Human) mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] AESGALIEAAK;LAECCIAANK;TVMLFNLGSAYCLR 3 4.7 0.95264 -0.76625 0 0 0 0 9.15312 0 0 0 10.5812 0 0 0 Q9H9A6 LRC40_HUMAN Leucine-rich repeat-containing protein 40 LRRC40 Homo sapiens (Human) intracellular signal transduction [GO:0035556] membrane [GO:0016020] ILDYSDK;SLPAEINR;SLPAEINRMK 3 2.8 0.96549 -1.2136 3.27202 0 10.5459 0 0 0 0 0 0 0 8.20119 10.7274 Q9H9B1 EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) chromatin organization [GO:0006325]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; facultative heterochromatin formation [GO:0140718]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] AAADAER 1 10.6 0.68341 0.16411 0 0 0 0 8.39896 0 0 0 0 0 0 0 Q9H9B1 EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) chromatin organization [GO:0006325]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; facultative heterochromatin formation [GO:0140718]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] APLLVLCEDHRGR;LGSPRSR;MGTYSLVPK;TDSPWIKPARK 4 5 0.97716 -1.4983 0 0 0 9.44774 0 0 0 0 0 9.42314 0 0 Q9H9B4 SFXN1_HUMAN Sideroflexin-1 SFXN1 Homo sapiens (Human) erythrocyte differentiation [GO:0030218]; iron ion transport [GO:0006826]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] HVSPLIGRFVPFAAVAAANCINIPLMR;VGIPVTDENGNR 2 12.1 0.94096 -0.58756 0 0 0 0 0 0 6.57648 0 0 0 9.82058 0 Q9H9C1 SPE39_HUMAN Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) VIPAS39 C14orf133 SPE39 VIPAR Homo sapiens (Human) cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; post-translational protein modification [GO:0043687]; spermatogenesis [GO:0007283]; vacuolar transport [GO:0007034] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023] protein-containing complex binding [GO:0044877] ESKRAVNSLR 1 2 0.86585 -0.089404 0 0 0 8.87064 0 0 0 0 0 0 0 0 Q9H9D4 ZN408_HUMAN Zinc finger protein 408 (PR domain zinc finger protein 17) ZNF408 PFM14 PRDM17 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AYTLATKLRR;LHSPSDQCPPR 2 2.9 0.98079 -1.7929 0 0 0 0 0 0 0 0 0 0 0 11.0206 Q9H9E3 COG4_HUMAN Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Homo sapiens (Human) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] identical protein binding [GO:0042802] ELDALLEQQNTIESK;QLDLAKNR;SLIAYLTTVTTWTIR;YLCLDKSVIELSRQGK;YLQVECDRQVEK 5 8.4 0.97272 -2.7426 0 0 0 0 0 10.0479 0 0 9.79299 0 9.55422 0 Q9H9F9 ARP5_HUMAN Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) ACTR5 ARP5 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] QASRSSDAQASSKGSAAGGGGAGEQA 1 4.3 0.87418 -0.10544 0 0 9.48826 0 0 0 0 0 0 0 0 0 Q9H9G7 AGO3_HUMAN Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) AGO3 EIF2C3 Homo sapiens (Human) miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; pre-miRNA processing [GO:0031054]; regulation of stem cell proliferation [GO:0072091]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] "double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]" EACISLEK;NTYSGLQLIIVILPGKTPVYAEVK 2 3.7 0.93485 -0.53069 0 0 0 9.69851 0 0 0 0 0 0 0 0 Q9H9H5 MA6D1_HUMAN MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) MAP6D1 Homo sapiens (Human) cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of microtubule cytoskeleton organization [GO:0070507] cis-Golgi network [GO:0005801]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017] GPGAGGRR;MAWPCISR 2 8 0.90765 -0.27667 0 0 0 0 6.74308 6.70915 0 0 0 0 0 8.9859 Q9H9J4 UBP42_HUMAN Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) USP42 Homo sapiens (Human) cell differentiation [GO:0030154]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] ANGLPGKLMPAPLLSLPEDK;EKFYPDRPR;FGNQEDAHEFLQYTVDAMQK;ITISIHNK;RSEQKDPLEEPK 5 5.2 0.96695 -1.2919 0 0 12.6751 10.0073 0 0 0 0 9.12184 0 0 10.7443 Q9H9L3 I20L2_HUMAN Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-) ISG20L2 HSD-38 HSD38 Homo sapiens (Human) ribosome biogenesis [GO:0042254]; RNA processing [GO:0006396] nucleolus [GO:0005730]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723] AAVSWLTPAPSK;ALEGNAK;ALQYFHPK;STLLLNLDFGEPPPKK 4 12.2 0.97456 -1.3931 0 0 10.1866 9.69249 0 11.9052 0 0 0 0 0 0 Q9H9L4 KANL2_HUMAN KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) KANSL2 C12orf41 NSL2 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] RLQHLLKEK 1 1.8 0.97792 -1.5054 0 13.7645 0 0 0 0 0 9.30993 0 0 0 0 Q9H9L7 AKIR1_HUMAN Akirin-1 AKIRIN1 C1orf108 Homo sapiens (Human) myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] DQPTFTLRQVGIICERLLK;LPTPEQIFQNIKQEYSRYQR 2 20.3 0.084243 0.38432 0 0 0 0 0 0 0 0 7.60977 0 9.79245 0 Q9H9P5 UNKL_HUMAN Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) UNKL C16orf28 ZC3H5L ZC3HDC5L Homo sapiens (Human) protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transferase activity [GO:0016740] CDGGDGCQYCHSR;CDGGDGCQYCHSRTEQQFHPESTKCNDMR 2 4.3 0.7119 0.15682 0 0 0 0 0 0 0 0 5.88964 0 0 0 Q9H9P5 UNKL_HUMAN Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) UNKL C16orf28 ZC3H5L ZC3HDC5L Homo sapiens (Human) protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transferase activity [GO:0016740] CDGGDGCQYCHSR;GVWWTLLGFR;TINPEGDKPSR 3 4.5 0.95548 -0.87436 0 0 0 0 0 0 0 12.5773 0 4.16511 0 0 Q9H9P8 L2HDH_HUMAN "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Duranin)" L2HGDH C14orf160 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; small molecule metabolic process [GO:0044281] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] 2-hydroxyglutarate dehydrogenase activity [GO:0047545] ALILRHPSLSIGVLEK;YLQKFIPEITISDILR 2 6.9 0.95234 -0.67266 0 0 0 0 4.00908 0 0 0 7.38258 0 0 0 Q9H9Q4 NHEJ1_HUMAN Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) NHEJ1 XLF Homo sapiens (Human) B cell differentiation [GO:0030183]; central nervous system development [GO:0007417]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; response to ionizing radiation [GO:0010212]; T cell differentiation [GO:0030217] DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; fibrillar center [GO:0001650]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] DNA end binding [GO:0045027]; DNA polymerase binding [GO:0070182] SQGVSSVNLLWPQLLR 1 5.1 0.84679 -0.072276 0 0 0 0 9.24227 0 0 0 0 0 0 0 Q9H9S5 FKRP_HUMAN Ribitol 5-phosphate transferase FKRP (EC 2.7.8.-) (Fukutin-related protein) (Ribitol-5-phosphate transferase) FKRP Homo sapiens (Human) adult walking behavior [GO:0007628]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; connective tissue development [GO:0061448]; connective tissue replacement [GO:0097709]; creatine metabolic process [GO:0006600]; diaphragm development [GO:0060539]; filtration diaphragm assembly [GO:0036058]; glial cell differentiation [GO:0010001]; glycolytic process [GO:0006096]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; localization of cell [GO:0051674]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; muscle contraction [GO:0006936]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; oxygen metabolic process [GO:0072592]; pentitol metabolic process [GO:0019519]; pentose metabolic process [GO:0019321]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein import [GO:0017038]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485]; protein tetramerization [GO:0051262]; reelin-mediated signaling pathway [GO:0038026]; respiratory system process [GO:0003016]; response to activity [GO:0014823]; response to alcohol [GO:0097305]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue regeneration [GO:0043403] cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; skeletal muscle myofibril [GO:0098723] "dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" GAEAGSVVDER 1 2.2 0.93558 -0.52054 0 0 0 0 0 0 0 0 0 0 9.37282 0 Q9H9T3 ELP3_HUMAN Elongator complex protein 3 (hELP3) (EC 2.3.1.311) (tRNA uridine(34) acetyltransferase) ELP3 Homo sapiens (Human) central nervous system development [GO:0007417]; neuron migration [GO:0001764]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; acetyltransferase activity [GO:0016407]; metal ion binding [GO:0046872]; phosphorylase kinase regulator activity [GO:0008607]; tRNA binding [GO:0000049]; tRNA uridine(34) acetyltransferase activity [GO:0106261]" GTGLYELWK;MKDLGIQCR;YDPFLQTRHR 3 5.1 0.93801 -0.57023 0 0 7.79578 0 0 8.94781 0 0 10.8735 0 0 0 Q9H9V9 JMJD4_HUMAN 2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4) JMJD4 Homo sapiens (Human) positive regulation of translational termination [GO:0045905]; protein hydroxylation [GO:0018126] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; peptidyl-lysine 4-dioxygenase activity [GO:0106156]; sequence-specific DNA binding [GO:0043565] LLVPRLVLTVSAPAEVR 1 3.7 0.82928 -0.02271 0 0 0 0 0 0 8.09397 0 0 0 0 0 Q9H9Y2 RPF1_HUMAN Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1) RPF1 BXDC5 Homo sapiens (Human) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134] IIPQCIARDFTDLIVINEDR;SSSSGKK 2 7.7 0.81802 -0.01737 0 0 0 0 0 0 0 0 0 0 0 7.98282 Q9H9Y6 RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) POLR1B Homo sapiens (Human) embryo implantation [GO:0007566]; neural crest formation [GO:0014029]; nucleologenesis [GO:0017126]; rRNA transcription [GO:0009303] chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] ELFFLPLGFALK;ETGVRCAGGHMDPGSRWR;LNFIRYLSHFR;NMYQCQMGK 4 4.3 0.9559 -0.98378 5.85756 0 0 0 0 0 6.17097 0 10.1927 0 0 0 Q9HA38 ZMAT3_HUMAN Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein) ZMAT3 PAG608 WIG1 Homo sapiens (Human) apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; protein transport [GO:0015031] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] LAEAQSNSFSESSELGQRR 1 6.6 0.29869 0.25235 0 0 0 0 0 0 6.97934 0 0 0 0 0 Q9HA65 TBC17_HUMAN TBC1 domain family member 17 TBC1D17 Homo sapiens (Human) "autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096] EFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMER 1 5.6 0.91637 -0.41612 0 0 0 0 6.81429 0 0 0 0 0 0 0 Q9HA82 CERS4_HUMAN Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) CERS4 LASS4 Homo sapiens (Human) ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] FWLPPNVTWTELEDRDGR;LTNRHTTAT 2 6.9 0.97994 -1.8772 0 0 0 0 0 0 0 0 0 12.0947 0 0 Q9HA90 EFCC1_HUMAN EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48) EFCC1 C3orf73 CCDC48 Homo sapiens (Human) calcium ion binding [GO:0005509] KTPAAEAKTLLAR;LEAELQRYR;LSLLEEKLVDVLQLLQR;WVRRLEAELQR 4 7.2 0.97495 -3.2764 0 0 0 12.6438 11.8795 0 13.7432 12.4561 0 0 0 13.2953 Q9HA92 RSAD1_HUMAN "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (Putative heme chaperone)" RSAD1 Homo sapiens (Human) porphyrin-containing compound biosynthetic process [GO:0006779] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; heme binding [GO:0020037]; metal ion binding [GO:0046872]" CSYCNFNKYIPR;TPSPVPGG 2 4.5 0.97789 -1.9488 0 0 0 0 0 0 0 0 0 10.4435 0 0 Q9HAB3 S52A2_HUMAN "Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)" SLC52A2 GPR172A PAR1 RFT3 Homo sapiens (Human) riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218] plasma membrane [GO:0005886] 4-hydroxybutyrate receptor activity [GO:0062124]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618] DCADPCDS;KDCADPCDS;LECPPAPINGTPGPPLDFLER 3 6.7 0.71268 0.14917 0 0 0 10.2471 4.55968 0 0 4.27053 5.84003 5.71924 0 0 Q9HAB8 PPCS_HUMAN Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) PPCS COAB Homo sapiens (Human) acetyl-CoA biosynthetic process [GO:0006085]; coenzyme A biosynthetic process [GO:0015937]; heart process [GO:0003015] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphopantothenate--cysteine ligase activity [GO:0004632]; protein homodimerization activity [GO:0042803] LETDPAIVINRAR;LGAQGRR 2 6.4 0.95579 -0.98286 0 10.8155 0 0 0 0 0 0 0 0 0 0 Q9HAC7 SUCHY_HUMAN Succinyl-CoA:glutarate CoA-transferase (EC 2.8.3.-) (Dermal papilla-derived protein 13) (Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT) (Succinate--hydroxymethylglutarate CoA-transferase) (EC 2.8.3.13) SUGCT C7orf10 DERP13 Homo sapiens (Human) mitochondrion [GO:0005739] succinate-hydroxymethylglutarate CoA-transferase activity [GO:0047369] ILDLPELIDNSKYK;VLAGPFATMNLGDLGAEVIK 2 7.8 0.9458 -0.65302 0 0 0 0 0 10.4743 6.148 0 0 0 0 0 Q9HAC8 UBTD1_HUMAN Ubiquitin domain-containing protein 1 UBTD1 Homo sapiens (Human) LLTDRTRLQETK 1 5.3 0.86659 -0.092708 0 0 0 0 0 8.73084 10.67 0 0 0 0 0 Q9HAD4 WDR41_HUMAN WD repeat-containing protein 41 WDR41 MSTP048 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; lysosomal membrane [GO:0005765] GTPase activator activity [GO:0005096] EPQGLAEK;ISCFQSTVK;SLRLFQK 3 5.2 0.97866 -2.0971 0 0 11.3799 0 0 0 0 0 0 0 10.2371 0 Q9HAE3 CLXN_HUMAN Calaxin (EF-hand calcium-binding domain-containing protein 1) CLXN EFCAB1 ODAD5 Homo sapiens (Human) cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regulation of cilium movement [GO:0003352]; regulation of flagellated sperm motility [GO:1901317]; regulation of signal transduction [GO:0009966] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] calcium ion binding [GO:0005509] KMDHDHDGK 1 4.3 0.88983 -0.20601 0 0 0 0 0 0 8.69031 0 10.4814 0 0 0 Q9HAF1 EAF6_HUMAN Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) MEAF6 C1orf149 CENP-28 EAF6 Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of hemopoiesis [GO:1903706] histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] EAERLFSK 1 4.2 0.91408 -0.33804 0 0 0 0 0 0 0 0 0 0 10.6487 0 Q9HAH1 ZN556_HUMAN Zinc finger protein 556 ZNF556 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AYCWATSFQR;YECSQCGK 2 3.9 0.96163 -1.0733 0 0 0 0 0 0 0 0 0 5.76795 0 0 Q9HAH7 FBRS_HUMAN Probable fibrosin-1 FBRS FBS FBS1 Homo sapiens (Human) VAYMILR;VSPATPK;WCAMHVR 3 4.6 0.97728 -1.5225 0 0 6.54415 0 0 0 0 0 0 0 8.66832 0 Q9HAJ7 SP30L_HUMAN Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) SAP30L NS4ATP2 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355] fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] "DNA binding [GO:0003677]; histone binding [GO:0042393]; non-sequence-specific DNA binding, bending [GO:0044378]; nucleosome binding [GO:0031491]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]" ETLAYFIYMVK;ETLAYFIYMVKSNKSR;HYKLQTRPGFNK 3 15.3 0.50461 0.18815 0 6.5702 10.2844 0 6.3226 0 0 0 0 11.2164 0 0 Q9HAK2 COE2_HUMAN Transcription factor COE2 (Early B-cell factor 2) (EBF-2) EBF2 COE2 Homo sapiens (Human) adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cell fate determination [GO:0001709]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLGAEMDSVR 1 1.7 0.9304 -0.48757 0 0 0 0 0 0 0 0 10.1685 0 0 0 Q9HAP6 LIN7B_HUMAN Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) LIN7B MALS2 VELI2 UNQ3116/PRO10200 Homo sapiens (Human) exocytosis [GO:0006887]; neurotransmitter secretion [GO:0007269]; protein transport [GO:0015031]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; synaptic vesicle transport [GO:0048489] "basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; synapse [GO:0045202]" PDZ domain binding [GO:0030165]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674] EVYEQLYDTLDITGSAEIR 1 9.2 0.82511 -0.020876 0 0 0 0 0 0 12.9763 0 0 11.1077 10.9076 0 Q9HAQ2 KIF9_HUMAN Kinesin-like protein KIF9 KIF9 Homo sapiens (Human) extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of flagellated sperm motility [GO:1901317]; regulation of podosome assembly [GO:0071801] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; podosome [GO:0002102]; sperm flagellum [GO:0036126]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DIRRGVVNNQQTDWSFK 1 2.2 0.48435 0.19005 0 0 0 0 0 0 0 7.99475 0 0 0 0 Q9HAR2 AGRL3_HUMAN Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; synapse assembly [GO:0007416] axon [GO:0030424]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930] MFHHTAILKPESGCLDNIK;MWNDTVR;STTPSVSGRR;YLEVQYECVPYKVEQK 4 3.6 0.91415 -0.33751 0 6.35419 0 0 0 8.72863 0 0 0 0 8.66558 0 Q9HAS3 S28A3_HUMAN Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3) SLC28A3 CNT3 Homo sapiens (Human) nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] EDDDEEMQQK;EDDDEEMQQKGCLERR;MEDDDEEMQQKGCLERR 3 2.7 0.9527 -0.75284 0 0 0 0 4.25678 0 0 8.61607 0 0 7.9397 0 Q9HAT2 SIAE_HUMAN Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase) SIAE YSG2 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764] sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681] KDNKIFEISCCSDHR 1 2.9 0.97764 -1.5005 0 0 0 0 0 0 0 0 0 0 0 11.0249 Q9HAT8 PELI2_HUMAN E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2) PELI2 Homo sapiens (Human) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; protein polyubiquitination [GO:0000209]; regulation of Toll signaling pathway [GO:0008592] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450] NQTVVVEYTHDK 1 2.9 0.89746 -0.23895 11.332 8.22964 4.87647 0 0 0 0 0 0 0 0 0 Q9HAU0 PKHA5_HUMAN Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) PLEKHA5 KIAA1686 PEPP2 Homo sapiens (Human) reproductive system development [GO:0061458] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" ATAELER;GGRVFFINEEAK;GTLYKYRPEEVDIDAK;LEAHSPK;TPEELTLLLIKLRR 5 4.8 0.96724 -1.3157 0 12.0391 4.78581 0 0 4.31586 0 11.2634 12.7559 0 0 0 Q9HAU4 SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) SMURF2 Homo sapiens (Human) "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of trophoblast cell migration [GO:1901165]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] AVEFFDEERR;DTGYQRLDLCK;LSANLHLVLNRQNQLK;LYVNWRFLRGIEAQFLALQK;SIPVNEENKKEYVR 5 9.5 0.97071 -1.3437 0 10.768 0 6.67342 0 0 0 9.59498 0 10.3897 0 0 Q9HAU5 RENT2_HUMAN Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2) UPF2 KIAA1408 RENT2 Homo sapiens (Human) "animal organ regeneration [GO:0031100]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] AAMDFCMNMNTK;KHQEEER;LCNSLEESIRQVQDLER;LGMEVNQPK;QAMHLDAR 5 4.2 0.96491 -1.2301 10.1131 0 0 0 0 0 8.56594 8.6323 0 0 0 0 Q9HAU6 TCTP8_HUMAN Putative translationally-controlled tumor protein-like protein TPT1P8 (Putative apoptosis inhibitor FKSG2) TPT1P8 FKSG2 Homo sapiens (Human) apoptotic process [GO:0006915] cytoplasm [GO:0005737] calcium ion binding [GO:0005509] LEEQRPERVK 1 7.2 0.98014 -1.5559 0 0 0 0 0 0 0 11.5112 0 0 0 0 Q9HAU8 RNPL1_HUMAN Aminopeptidase RNPEPL1 (EC 3.4.11.-) (Arginyl aminopeptidase-like 1) (Methionyl aminopeptidase) (EC 3.4.11.18) RNPEPL1 Homo sapiens (Human) proteolysis [GO:0006508] initiator methionyl aminopeptidase activity [GO:0004239]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] ITTETYGAAFTCLETAFR 1 2.5 0.78453 0.028005 0 0 0 0 0 0 0 0 0 0 6.94591 0 Q9HAV4 XPO5_HUMAN Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) miRNA metabolic process [GO:0010586]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; RNA export from nucleus [GO:0006405] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RISC complex [GO:0016442]; RNA nuclear export complex [GO:0042565] mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; pre-miRNA binding [GO:0070883]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] ALDMLDAEK;ASMTNLVKMGFPSKTDSPSCEYSR;DIQQTLTQNMER;IVVEMIK;LACRLDPK;RTCWPTDLEEAK;TDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMR 7 8.1 0.97574 -5.0893 11.508 12.5185 0 0 0 0 0 10.2226 11.988 10.6928 0 0 Q9HAV5 TNR27_HUMAN Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031] MDCQENEYWDQWGR;MDCQENEYWDQWGRCVTCQR 2 6.7 0.7136 0.1448 0 6.44037 0 0 6.51759 6.51931 6.2438 0 0 0 0 6.65335 Q9HAV7 GRPE1_HUMAN "GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)" GRPEL1 GREPEL1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150] "mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]" adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] ALADTENLRQR;ETVEKYKR;LLCTATKQK;TLRPALVGVVK 4 18 0.95222 -0.77015 0 0 10.1893 0 0 0 0 0 0 7.63089 10.3231 0 Q9HAW4 CLSPN_HUMAN Claspin (hClaspin) CLSPN Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; peptidyl-serine phosphorylation [GO:0018105] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] anaphase-promoting complex binding [GO:0010997]; DNA secondary structure binding [GO:0000217] DLFETGLEDENNSPLEDEESLESIR;KIHMKTMLDDDK;TIHDFFKR 3 3.4 0.98098 -2.0238 0 0 0 0 0 0 0 0 0 11.6858 11.6994 0 Q9HAW9 UD18_HUMAN UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) UGT1A8 GNT1 UGT1 Homo sapiens (Human) cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of steroid metabolic process [GO:0045939]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; fatty acid binding [GO:0005504]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496] AMAIADALGK;IPQTVLWR;VRNHIMHLEEHLFCQYFSK;YFSLPSVVFAR 4 9.1 0.9044 -0.26852 0 0 0 0 9.26144 0 10.1447 0 10.6341 7.26547 0 0 Q9HAY2 MAGF1_HUMAN Melanoma-associated antigen F1 (MAGE-F1) (MAGE-F1 antigen) MAGEF1 Homo sapiens (Human) negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; protein ubiquitination [GO:0016567] nucleus [GO:0005634] EALADEADRARAK;LGVQPSK;LGVQPSKYHFLFGYPK;LIMEDFVQQRYLSYR 4 14.3 0.95558 -0.93588 0 0 0 0 0 0 0 0 10.3405 9.95303 0 0 Q9HAY6 BCDO1_HUMAN "Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)" BCO1 BCDO BCDO1 BCMO1 Homo sapiens (Human) beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238] cytosol [GO:0005829] "beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]" CGEDFYATSETNYIR;DGEVYYR;YVFATGVQWSPIPTKIIKYDILTK 3 8.4 0.97802 -2.1373 0 0 0 9.44919 8.35416 9.11267 0 0 12.1805 0 0 0 Q9HAZ1 CLK4_HUMAN Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) CLK4 Homo sapiens (Human) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] ITLDEALQHPFFDLLK;MLEYDPTQRITLDEALQHPFFDLLK;SLNERDYR 3 6.9 0.93092 -0.48932 0 12.7029 11.585 0 0 10.846 0 0 0 0 0 0 Q9HAZ2 PRD16_HUMAN Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) PRDM16 KIAA1675 MEL1 PFM13 Homo sapiens (Human) brown fat cell differentiation [GO:0050873]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular respiration [GO:0043457]; regulation of transcription by RNA polymerase II [GO:0006357] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]" AAEEAFEVK;CDECDELFQSK;CDQCPKAFNWKSNLIR;IFPRSANLTR;SFSISSNLQRHVR 5 4.6 0.95266 -0.75852 0 8.09677 2.60855 8.44232 0 0 0 9.62417 0 0 10.7117 0 Q9HB09 B2L12_HUMAN Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein) BCL2L12 BPR Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981] membrane [GO:0016020]; nucleus [GO:0005634] ITGSPIDR 1 8.7 0.91566 -0.37331 0 0 0 8.82066 0 0 0 0 0 0 0 0 Q9HB15 KCNKC_HUMAN Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2) KCNK12 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805] endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982] LPRPSCCCCCCR;LPRPSCCCCCCRR 2 3 0.21117 0.32378 0 0 0 0 0 5.73817 0 0 5.94718 0 0 0 Q9HB19 PKHA2_HUMAN Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) PLEKHA2 TAPP2 Homo sapiens (Human) positive regulation of cell-matrix adhesion [GO:0001954] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]" DVLKTHECLVK 1 2.6 0.88703 -0.18249 0 0 0 0 0 0 0 0 0 0 8.2436 0 Q9HB21 PKHA1_HUMAN Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) PLEKHA1 TAPP1 Homo sapiens (Human) androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]" LSNPCIQR;LTYISKVSDATK 2 6 0.97832 -2.067 11.1239 0 0 0 0 0 0 0 0 0 8.17228 0 Q9HB29 ILRL2_HUMAN Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2) IL1RL2 IL1RRP2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell differentiation [GO:0045582]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] "interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" QYEVLNGITVSITER 1 2.6 0.78304 0.025919 0 0 0 0 7.11134 0 0 0 0 0 0 0 Q9HB40 RISC_HUMAN Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) SCPEP1 RISC SCP1 MSTP034 UNQ265/PRO302 Homo sapiens (Human) blood vessel diameter maintenance [GO:0097746]; negative regulation of blood pressure [GO:0045776]; proteolysis [GO:0006508]; retinoic acid metabolic process [GO:0042573] cytosol [GO:0005829]; extracellular exosome [GO:0070062] serine-type carboxypeptidase activity [GO:0004185] ALYSDPK;EATELWGK 2 3.3 0.95483 -0.8241 0 0 0 8.73904 0 0 0 0 0 0 0 8.84947 Q9HB55 CP343_HUMAN Cytochrome P450 3A43 (EC 1.14.14.1) CYP3A43 Homo sapiens (Human) cytochrome metabolic process [GO:1903604]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 6-beta-hydroxylase activity [GO:0050649]" GLAVMVPIYALHHDPK 1 3.2 0.77941 0.034372 0 0 0 0 0 0 0 0 6.48599 0 0 0 Q9HB58 SP110_HUMAN Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) SP110 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DICSSSKRR;DLKDVLGFHEANDGGFWTLP;KSLPGGTASSR;MLWSCTFCRMK;VGASYEWQSR 5 8.9 0.9812 -1.5914 0 0 0 9.4617 0 7.49081 0 0 9.17642 9.97957 13.0064 0 Q9HB63 NET4_HUMAN Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein) NTN4 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; basement membrane assembly [GO:0070831]; cell migration [GO:0016477]; neuron remodeling [GO:0016322]; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling [GO:0060668]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] extracellular region [GO:0005576]; laminin complex [GO:0043256]; plasma membrane [GO:0005886] laminin-1 binding [GO:0043237] ACNPRMGNLALGR;CDKCNAAYPHLAHLPSAMADSSFR;ILSAHDK 3 7 0.95987 -1.0474 0 0 0 6.503 0 0 0 0 8.95155 0 0 0 Q9HB65 ELL3_HUMAN RNA polymerase II elongation factor ELL3 ELL3 Homo sapiens (Human) "DNA-templated transcription elongation [GO:0006354]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; neural precursor cell proliferation [GO:0061351]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of epithelial to mesenchymal transition [GO:0010717]; snRNA transcription by RNA polymerase II [GO:0042795]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]" cell junction [GO:0030054]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023] cis-regulatory region sequence-specific DNA binding [GO:0000987] FIELGAEIK;GTPEYKVLEDKIIQEYK;LCFTQAARTSLLLLRLNDAALR 3 12.1 0.97553 -1.4382 0 0 0 0 0 0 9.54593 0 10.4606 0 0 9.65905 Q9HB71 CYBP_HUMAN Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) CACYBP S100A6BP SIP PNAS-107 Homo sapiens (Human) heart development [GO:0007507] beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625] DALTAEK;IETEIKNKMQQK;MASEELQK;TINKAWVESREK 4 17.1 0.97846 -2.0725 0 12.4279 9.041 0 0 8.75916 0 0 0 0 0 11.4376 Q9HB75 PIDD1_HUMAN p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC] PIDD1 LRDD PIDD Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175] YQDSIRR 1 0.8 0.93307 -0.50042 0 0 0 0 0 0 0 0 0 9.61137 0 0 Q9HB75 PIDD1_HUMAN p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC] PIDD1 LRDD PIDD Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175] GAGQDRGPGVTR;LPVGLRDSR;LPVGLRDSRGAGQDR 3 6.4 0.9822 -1.5852 0 0 0 0 0 0 0 9.06294 0 5.54229 11.0146 0 Q9HB75 PIDD1_HUMAN p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC] PIDD1 LRDD PIDD Homo sapiens (Human) "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175] SAAAPGP 1 2.3 0.68672 0.16352 0 0 4.74362 0 9.88593 9.62379 10.7111 0 8.2006 0 0 0 Q9HB96 FANCE_HUMAN Fanconi anemia group E protein (Protein FACE) FANCE FACE Homo sapiens (Human) interstrand cross-link repair [GO:0036297] centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ALGSRGWEPFDWGR;FSVLMEKLCK;LELKPLLLRLPR;RGLGVLRALGSR;YQANITETQR 5 9.9 0.97466 -3.7197 7.14873 0 0 9.17043 0 9.84809 9.81638 9.75205 0 0 0 0 Q9HBA0 TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) TRPV4 VRL2 VROAC Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion import into cytosol [GO:1902656]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell volume homeostasis [GO:0006884]; cell-cell junction assembly [GO:0007043]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; intracellular calcium ion homeostasis [GO:0006874]; microtubule polymerization [GO:0046785]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of striated muscle contraction [GO:0045989]; positive regulation of vascular permeability [GO:0043117]; regulation of aerobic respiration [GO:1903715]; regulation of response to osmotic stress [GO:0047484]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; vasopressin secretion [GO:0030103] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; monoatomic cation channel activity [GO:0005261]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; stretch-activated, monoatomic cation-selective, calcium channel activity [GO:0015275]" ADMRRQDSR;APAPQPPPILKVFNRPILFDIVSR;HIWKLQWATTILDIER 3 5.6 0.97831 -1.9282 0 0 0 8.69599 0 0 0 0 13.0668 0 8.34532 0 Q9HBB8 CDHR5_HUMAN Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168 Homo sapiens (Human) brush border assembly [GO:1904970]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; regulation of microvillus length [GO:0032532] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839] RFSVVDMAALGGVLGALLLLALLGLAVLVHK 1 3.7 0.37081 0.2273 0 0 0 0 0 0 0 0 0 0 3.73747 0 Q9HBD1 RC3H2_HUMAN Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) RC3H2 MNAB RNF164 Homo sapiens (Human) "B cell homeostasis [GO:0001782]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; multicellular organism growth [GO:0035264]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; regulation of miRNA metabolic process [GO:2000628]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]" cell surface [GO:0009986]; cytoplasmic stress granule [GO:0010494]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; P-body [GO:0000932] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630] DRFIVTDLSGHRK;EPPKQKK;NDFLKPVANGKMVNS;QQGGCPR 4 3.5 0.95541 -0.94346 0 11.3258 8.17852 0 0 0 0 0 0 7.6367 0 0 Q9HBE1 PATZ1_HUMAN "POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein)" PATZ1 PATZ RIAZ ZBTB19 ZNF278 ZSG Homo sapiens (Human) male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of DNA-templated transcription [GO:0006355]; regulation of immune system process [GO:0002682]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217] male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]" QVHTSERPHK 1 1.5 0.89701 -0.23453 0 0 0 0 0 0 9.5872 0 0 0 0 0 Q9HBE4 IL21_HUMAN Interleukin-21 (IL-21) (Za11) IL21 Homo sapiens (Human) cell maturation [GO:0048469]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; germinal center B cell differentiation [GO:0002314]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165]; T follicular helper cell differentiation [GO:0061470]; tyrosine phosphorylation of STAT protein [GO:0007260] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; interleukin-2 receptor binding [GO:0005134] FKSLLQKMIHQHLSSR 1 9.9 0.96514 -1.1509 0 0 0 0 0 0 10.8168 0 0 0 0 0 Q9HBF4 ZFYV1_HUMAN Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436 Homo sapiens (Human) cellular response to starvation [GO:0009267]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]; positive regulation by host of viral genome replication [GO:0044829] autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407] "1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270]" ACGEGFCDSCSSK;HHCRACGQGFCDECSHDR;HPGVIFK;NVQLAVTEAQVDDEGGTLIAR;QERLRNHER;VGEAVQNTLGAVVTAIDIPLGLVK;YSHQYDNR 7 12.9 0.95533 -0.94399 5.80627 2.62775 0 0 5.87347 0 0 2.69988 9.48907 7.52395 8.19283 6.39027 Q9HBG6 IF122_HUMAN Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140) IFT122 SPG WDR10 WDR140 Homo sapiens (Human) camera-type eye morphogenesis [GO:0048593]; cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; establishment of protein localization to organelle [GO:0072594]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; spinal cord dorsal/ventral patterning [GO:0021513] ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391] GEYILLGGSDKQVSLFTKDGVR;SAVYSSQGSEAEEEEPEEEDDSPR;VTATDKAPK 3 4.3 0.96647 -1.2775 0 13.5657 0 0 0 0 0 6.29805 0 0 5.01565 0 Q9HBG7 LY9_HUMAN T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) LY9 CDABP0070 Homo sapiens (Human) cell adhesion [GO:0007155]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] SRDPYKNR;VWVSSQDCSLKISQLK 2 3.7 0.9738 -1.3983 0 0 0 9.94317 0 0 0 0 0 0 0 0 Q9HBH0 RHOF_HUMAN Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia) RHOF ARHF RIF Homo sapiens (Human) actin filament organization [GO:0007015]; cell migration [GO:0016477]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901] AALYLECSAK;RRLCLLL;VALSALK 3 11.4 0.98099 -2.026 0 0 0 0 0 0 0 9.01288 0 0 0 0 Q9HBH1 DEFM_HUMAN "Peptide deformylase, mitochondrial (EC 3.5.1.88) (Polypeptide deformylase)" PDF PDF1A Homo sapiens (Human) co-translational protein modification [GO:0043686]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; positive regulation of cell population proliferation [GO:0008284]; translation [GO:0006412] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; peptide deformylase activity [GO:0042586] LVQVMRR;VFVNPSLR 2 6.2 0.96208 -1.0788 0 0 0 0 0 0 0 13.1532 0 0 12.8059 0 Q9HBH5 RDH14_HUMAN Retinol dehydrogenase 14 (EC 1.1.1.300) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4) RDH14 PAN2 SDR7C4 UNQ529/PRO1072 Homo sapiens (Human) osteoblast differentiation [GO:0001649] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 11-cis-retinol dehydrogenase activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650] AEEAAGQLR;LANILFTRELARR;VIMGCRDRAR 3 9.5 0.97426 -3.0507 0 0 0 9.92101 0 11.5377 0 0 0 7.93381 12.5309 0 Q9HBI1 PARVB_HUMAN Beta-parvin (Affixin) PARVB CGI-56 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell projection assembly [GO:0030031]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; lamellipodium assembly [GO:0030032]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin binding [GO:0003779] APIRLPEHVTVQVVVVR;ARPEDVVNLDLK;LSVVKKSLITFVNK 3 11.8 0.87288 -0.10432 8.83314 0 0 0 0 0 0 5.37882 0 0 0 5.0914 Q9HBI5 CEP15_HUMAN Centrosomal protein 15 (Centrosomal protein 15 kDa) CEP15 C3orf14 HT021 Homo sapiens (Human) cilium [GO:0005929] APYPFAVENQNEAENTIQNEAQR;LGDQHTEK;TSLFAQEIRLSKR 3 34.4 0.88171 -0.1775 0 0 0 0 8.55105 7.29462 7.11551 0 0 0 0 0 Q9HBJ0 PLAC1_HUMAN Placenta-specific protein 1 PLAC1 Homo sapiens (Human) placenta development [GO:0001890] extracellular region [GO:0005576] SPWLTKPCSMRVASK;VTECGIR;VTECGIRAK 3 11.3 0.9804 -1.8011 0 0 0 0 0 0 0 0 8.33123 0 9.48458 0 Q9HBJ7 UBP29_HUMAN Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.4.19.12) (Deubiquitinating enzyme 29) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) USP29 Homo sapiens (Human) defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked deubiquitination [GO:0071108]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] LSRVLIIHLKR;TSFYSICNKPSYQKMPLFMSK 2 3.5 0.8884 -0.18865 0 5.29517 0 0 0 0 7.15046 0 6.98014 0 0 0 Q9HBJ8 CLTRN_HUMAN Collectrin (Transmembrane protein 27) CLTRN TMEM27 UNQ679/PRO1312 Homo sapiens (Human) calcium-ion regulated exocytosis [GO:0017156]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; positive regulation of amino acid transport [GO:0051957]; positive regulation of L-proline import across plasma membrane [GO:1905737]; regulation of transmembrane transporter activity [GO:0022898]; SNARE complex assembly [GO:0035493] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] EATEISHVLLCNVTQR;VSFWFVVTDPSK 2 12.6 0.50127 0.18901 0 0 6.77413 0 0 0 0 10.685 0 0 0 0 Q9HBL0 TENS1_HUMAN Tensin-1 (EC 3.1.3.-) TNS1 TNS Homo sapiens (Human) cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] actin binding [GO:0003779]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; RNA binding [GO:0003723] AQDSEPK;AQFSVAGVHTVPGSPQAR;GDMTHELVR;QSHPLTQSR;VTPSVQPHLQPIR 5 3 0.98115 -1.6911 0 10.6457 0 8.61791 0 10.1094 0 0 9.03897 0 0 0 Q9HBL7 PLRKT_HUMAN Plasminogen receptor (KT) (Plg-R(KT)) PLGRKT C9orf46 AD025 MDS030 Homo sapiens (Human) chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of plasminogen activation [GO:0010756] mitochondrion [GO:0005739]; plasma membrane [GO:0005886] GMITFESIEKARK 1 8.8 0.76432 0.062148 6.71026 10.7368 0 0 0 0 0 0 0 0 0 0 Q9HBL8 NMRL1_HUMAN NmrA-like family domain-containing protein 1 NMRAL1 HSCARG Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802] LGFPGAR 1 2.3 0.90872 -0.30941 0 0 12.3065 0 0 8.82136 8.79594 0 0 9.43598 0 0 Q9HBQ8 GGA2B_HUMAN Putative golgin subfamily A member 2B (Golgin subfamily A member 2-like protein 1) GOLGA2P5 GOLGA2B GOLGA2L1 PP1757 Homo sapiens (Human) ECTASAWLICWPRPRR;NLRQQPQPQELGVIPCVGRPTRPCR 2 42.3 0.88841 -0.20327 0 6.94696 0 0 0 0 0 7.73877 0 0 0 0 Q9HBR0 S38AA_HUMAN Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) SLC38A10 PP1744 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348] Golgi apparatus [GO:0005794]; membrane [GO:0016020] L-amino acid transmembrane transporter activity [GO:0015179] DLGPHAEGQLAPR;HEPPVPHDKVVVDEGQDR;LLDQQEK;LSAQDPVVAVAEDGREKPKLPK 4 5.4 0.95385 -0.92731 11.0011 0 2.44438 0 0 0 0 10.244 10.2669 0 0 0 Q9HBT6 CAD20_HUMAN Cadherin-20 CDH20 CDH7L3 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] TALMNMDREAK 1 1.4 0.88614 -0.18239 0 0 0 0 0 0 0 0 0 0 9.75547 0 Q9HBT7 ZN287_HUMAN Zinc finger protein 287 (Zinc finger protein with KRAB and SCAN domains 13) ZNF287 ZKSCAN13 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKSYECEECGK;TFSQSTHLLQHQKIHTGK 2 3.8 0.94375 -0.62774 0 0 6.90147 4.05961 0 0 0 0 0 0 0 0 Q9HBU1 BARX1_HUMAN Homeobox protein BarH-like 1 BARX1 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; digestive system development [GO:0055123]; endothelial cell differentiation [GO:0045446]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of transcription by RNA polymerase II [GO:0006357]; spleen development [GO:0048536]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IVLQGGGLESPTKPK 1 5.9 0.78431 0.029082 0 6.90256 0 0 0 0 0 0 0 0 0 0 Q9HBU6 EKI1_HUMAN Ethanolamine kinase 1 (EKI 1) (EC 2.7.1.82) ETNK1 EKI1 Homo sapiens (Human) phosphatidylethanolamine biosynthetic process [GO:0006646] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305] HVCNPAIFRLIARQLAK 1 3.8 0.86456 -0.085044 0 0 0 0 0 0 0 0 0 7.15916 0 0 Q9HBX8 LGR6_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 6 LGR6 UNQ6427/PRO21331 VTS20631 Homo sapiens (Human) axon guidance [GO:0007411]; bone regeneration [GO:1990523]; cell population proliferation [GO:0008283]; G protein-coupled receptor signaling pathway [GO:0007186]; negative chemotaxis [GO:0050919]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] heparin binding [GO:0008201]; protein-hormone receptor activity [GO:0016500]; Roundabout binding [GO:0048495]; transmembrane signaling receptor activity [GO:0004888] AGDSGPLAYAAAGELEK;ALNNLPALQAMTLALNR;SFEGLSSLR 3 4.4 0.93705 -0.54231 0 0 0 0 0 0 8.22077 0 3.30039 0 0 0 Q9HBX9 RXFP1_HUMAN Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) RXFP1 LGR7 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; myofibroblast differentiation [GO:0036446]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; metal ion binding [GO:0046872] AVPSVSSNVTAMSLQWNLIRK;LDELDLGSNK 2 4.1 0.89817 -0.23387 0 0 0 9.57788 0 0 0 0 0 0 0 0 Q9HBX9 RXFP1_HUMAN Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) RXFP1 LGR7 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; myofibroblast differentiation [GO:0036446]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; metal ion binding [GO:0046872] AVKDGSEK;AVPSVSSNVTAMSLQWNLIRK;GLNSLTKLSRAVK 3 20.6 0.87384 -0.1055 0 0 0 0 0 0 10.4277 0 0 8.16033 8.22096 0 Q9HBY8 SGK2_HUMAN Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2) SGK2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; sodium channel regulator activity [GO:0017080] VLQKKSILK 1 2.5 0.97832 -1.5084 0 0 0 0 8.16897 8.3092 0 0 0 0 0 0 Q9HBZ2 ARNT2_HUMAN Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1) ARNT2 BHLHE1 KIAA0307 Homo sapiens (Human) brain development [GO:0007420]; central nervous system development [GO:0007417]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "aryl hydrocarbon receptor binding [GO:0017162]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DILEFCHPEDQSHLR;MTQYITELSDMVPTCSALARKPDKLTILR;SFICRMR 3 7.1 0.96392 -1.1811 0 0 0 0 0 0 0 0 0 0 9.50635 6.45946 Q9HC07 TM165_HUMAN Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) TMEM165 TPARL Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; manganese ion transmembrane transport [GO:0071421]; manganese ion transport [GO:0006828]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751] cis-Golgi network membrane [GO:0033106]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] antiporter activity [GO:0015297]; calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384] LLLLFLVPLLWAPAAVR 1 5.2 0.68286 0.1653 0 0 0 0 0 0 0 3.55262 0 0 9.52462 8.43842 Q9HC10 OTOF_HUMAN Otoferlin (Fer-1-like protein 2) OTOF FER1L2 Homo sapiens (Human) membrane fusion [GO:0061025]; regulation of neurotransmitter secretion [GO:0046928]; sensory perception of sound [GO:0007605]; synaptic vesicle exocytosis [GO:0016079] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] IVISKKESMFSWDETEYK;LGKTDIRDK;QDTDVHYHSLTGEGNFNWR;YKWLIIKIVLALLGLLMLGLFLYSLPGYMVK;YTLVGSHAVSSLRRFIYRPPDR 5 8 0.97593 -2.2572 6.16678 0 0 0 0 0 0 0 8.75268 8.22067 10.2825 10.6167 Q9HC16 ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G) APOBEC3G MDS019 Homo sapiens (Human) base conversion or substitution editing [GO:0016553]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; transposable element silencing [GO:0010526] apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] cytidine deaminase activity [GO:0004126]; dCTP deaminase activity [GO:0008829]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GQVPPGLQSLCR;MKPHFRNTVER 2 29.1 0.89595 -0.23653 0 0 0 0 0 0 9.2206 0 0 0 0 0 Q9HC24 LFG4_HUMAN Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) TMBIM4 GAAP LFG4 CGI-119 Homo sapiens (Human) apoptotic process [GO:0006915]; endoplasmic reticulum unfolded protein response [GO:0030968]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] calcium channel activity [GO:0005262] MADPDPR 1 2.9 0.91295 -0.32188 0 0 0 6.62708 0 0 0 0 0 0 0 0 Q9HC29 NOD2_HUMAN Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1) NOD2 CARD15 Homo sapiens (Human) adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0002815]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptidoglycan [GO:0071224]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; detection of muramyl dipeptide [GO:0032498]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; intestinal stem cell homeostasis [GO:0036335]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; phagocytosis [GO:0006909]; positive regulation of B cell activation [GO:0050871]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0006965]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gamma-delta T cell activation [GO:0046645]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitophagy [GO:1901526]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of xenophagy [GO:1904417]; regulation of appetite [GO:0032098]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil chemotaxis [GO:0090022]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to nutrient [GO:0007584]; stress-activated MAPK cascade [GO:0051403]; temperature homeostasis [GO:0001659]; toll-like receptor 2 signaling pathway [GO:0034134]; xenophagy [GO:0098792] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; muramyl dipeptide binding [GO:0032500]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] RHHEPGVADRLIR;RQACARWCLAR 2 2.3 0.95547 -0.80868 0 0 12.4602 0 0 0 0 0 0 0 6.64918 10.5856 Q9HC35 EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) EML4 C2orf2 EMAPL4 Homo sapiens (Human) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017] ADQFLVGTSR;IILWDHDLNPER 2 2.2 0.92079 -0.44645 0 0 0 0 0 0 0 0 0 10.7573 5.30732 0 Q9HC36 MRM3_HUMAN "rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)" MRM3 RNMTL1 HC90 Homo sapiens (Human) rRNA 2'-O-methylation [GO:0000451]; rRNA processing [GO:0006364] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039] AGAVPKMFFFSR;KAPSEASAQEQR 2 5.7 0.96505 -1.1557 0 0 4.93636 0 0 0 0 0 0 0 0 0 Q9HC38 GLOD4_HUMAN Glyoxalase domain-containing protein 4 GLOD4 C17orf25 CGI-150 My027 Homo sapiens (Human) extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] cadherin binding [GO:0045296] ELPDLEDLMK;ILTPLVSLDTPGK;SLPQSDPVLK 3 10.5 0.7271 0.12534 0 0 0 0 0 0 0 7.44518 1.1488 0 9.77121 9.4199 Q9HC44 GPBL1_HUMAN Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) GPBP1L1 SP192 Homo sapiens (Human) DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] ANRMEHKSGSLSSSR;KGCAFQEKPPMEIR 2 6.1 0.93749 -0.57568 3.9835 0 0 0 0 5.29587 0 0 0 0 0 0 Q9HC56 PCDH9_HUMAN Protocadherin-9 PCDH9 Homo sapiens (Human) cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell-cell contact zone [GO:0044291]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060] calcium ion binding [GO:0005509] FKAAQRSK;LIKIKIIVK;MDLRDFYLLAALIACLR;RTMETPLDR;SPLSTFAPQK;YTIVSGNNKGLFR 6 5.3 0.98018 -1.8659 6.18071 0 9.93525 0 0 0 0 3.31794 0 10.4817 0 10.4573 Q9HC62 SENP2_HUMAN Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) fat cell differentiation [GO:0045444]; mRNA transport [GO:0051028]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of Wnt signaling pathway [GO:0030111]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139] GPLCSLR;MYRWLVR 2 2.4 0.86558 -0.086924 0 0 0 0 0 0 0 10.798 0 0 0 10.2595 Q9HC73 CRLF2_HUMAN Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) CRLF2 CRL2 ILXR TSLPR Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of mast cell activation [GO:0033005]; positive regulation of receptor signaling pathway via STAT [GO:1904894] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] QENTCNVTIEGLDAEK;TNLTFHYR 2 6.5 0.9169 -0.36112 0 6.10731 9.7062 0 0 0 0 0 0 0 0 0 Q9HC77 CPAP_HUMAN Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) CPAP CENPJ LAP LIP1 Homo sapiens (Human) astral microtubule nucleation [GO:0030954]; cell division [GO:0051301]; centriole elongation [GO:0061511]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; microtubule nucleation [GO:0007020]; microtubule polymerization [GO:0046785]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centriole replication [GO:0046601]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of spindle assembly [GO:1905832]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin small complex [GO:0008275]; microtubule [GO:0005874]; procentriole replication complex [GO:0120099] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631] AGVILNR;AVPQKTNPADPISHCNR;DVDLDLSDK;RGEGLARFTNAK;VILFPNGTR 5 4 0.97873 -1.9723 0 11.444 0 0 0 0 10.9274 0 0 10.7948 0 0 Q9HC78 ZBT20_HUMAN Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288) ZBTB20 DPZF ZNF288 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; lipid homeostasis [GO:0055088]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" NESEECTEDTDQAEGTESEPK 1 2.8 0.65309 0.16939 0 0 0 0 0 0 0 6.22302 0 0 0 0 Q9HC84 MUC5B_HUMAN "Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)" MUC5B MUC5 Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] CGLTDNENCLK;CQWTEWFDEDYPK;CVAQCGCYDK;MRGLMCANSQQSPPLCHDYELR;RGLVGSRPVVTRVVIK;STATTPTATSVTAIPSSSLGTAWTR;TGCCYSCEEDSCQVR;VDCNTCTCR 8 2.1 0.89914 -0.2573 7.88228 7.20838 9.98171 0 6.43099 6.75181 5.66044 10.0961 8.8166 7.69404 5.02936 0 Q9HC96 CAN10_HUMAN Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10) CAPN10 KIAA1845 Homo sapiens (Human) cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to insulin stimulus [GO:0032869]; positive regulation of D-glucose import [GO:0046326]; positive regulation of insulin secretion [GO:0032024]; positive regulation of intracellular transport [GO:0032388]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; proteolysis [GO:0006508]; regulation of actin cytoskeleton organization [GO:0032956]; type B pancreatic cell apoptotic process [GO:0097050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cytoskeletal protein binding [GO:0008092]; SNARE binding [GO:0000149] NFASYPTNPCFPFSVPEGPGPRCVR 1 3.7 0.88799 -0.20301 0 0 0 0 0 0 9.16154 0 0 0 0 0 Q9HC98 NEK6_HUMAN Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) NEK6 Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear membrane disassembly [GO:0007077]; mitotic spindle organization [GO:0007052]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; spindle assembly [GO:0051225] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinesin binding [GO:0019894]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] YFVQLCSAVEHMHSRRVMHR 1 6.4 0.95688 -1.0249 12.0821 0 0 0 0 0 0 0 0 0 0 0 Q9HCC0 MCCB_HUMAN "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" MCCC2 MCCB Homo sapiens (Human) branched-chain amino acid catabolic process [GO:0009083]; coenzyme A metabolic process [GO:0015936]; L-leucine catabolic process [GO:0006552] cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; methylcrotonoyl-CoA carboxylase activity [GO:0004485] DGAKMVAAVACAQVPK;QADVFPDR;QGTIFLAGPPLVK 3 6.6 0.98131 -1.7551 0 8.24921 0 0 0 7.38681 0 0 0 0 9.64409 0 Q9HCC8 GDPD2_HUMAN Glycerophosphoinositol inositolphosphodiesterase GDPD2 (EC 3.1.4.43) (Glycerophosphodiester phosphodiesterase 3) (Glycerophosphodiester phosphodiesterase domain-containing protein 2) (Osteoblast differentiation promoting factor) GDPD2 GDE3 OBDPF UNQ1935/PRO4418 Homo sapiens (Human) actin filament organization [GO:0007015]; lipid metabolic process [GO:0006629]; positive regulation of osteoblast differentiation [GO:0045669] actin filament [GO:0005884]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol inositolphosphodiesterase activity [GO:0047394]; metal ion binding [GO:0046872] TGLETAVLLTRINNFMME 1 3.3 0.92162 -0.44124 0 0 0 7.30058 0 0 0 0 0 0 0 0 Q9HCC9 LST2_HUMAN Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) ZFYVE28 KIAA1643 LST2 Homo sapiens (Human) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175] cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] EYYVQQEVIVLFCETVER;TLFEVMATKPETDDK 2 3.7 0.91008 -0.28388 0 0 0 0 0 0 0 0 8.93593 0 0 0 Q9HCC9 LST2_HUMAN Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) ZFYVE28 KIAA1643 LST2 Homo sapiens (Human) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175] cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] EYYVQQEVIVLFCETVER;LAIVCPLLPAHPR 2 10.8 0.87407 -0.10692 0 12.4237 0 0 10.8315 0 0 0 0 0 8.05317 0 Q9HCD5 NCOA5_HUMAN Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966] actin cytoskeleton [GO:0015629]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] DPMYDRYRDMR;EELYRQYFEEIQRR;NMPQADAMVLVARNYERYK 3 7.6 0.96505 -1.1559 0 0 0 0 0 0 0 9.54618 11.6301 0 0 0 Q9HCD6 TANC2_HUMAN "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001] axon [GO:0030424]; dendritic spine [GO:0043197] MLLTGGKSSRK;QIASDSPHASPK;RSSRQFAAALEDLNEAIK;SCDELSPVSPTQGGYPSEPTRSR 4 3.2 0.98035 -2.0184 0 0 0 6.54959 0 0 7.45294 0 10.5203 0 0 0 Q9HCE0 EPG5_HUMAN Ectopic P granules protein 5 homolog EPG5 KIAA1632 Homo sapiens (Human) autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; defense response to virus [GO:0051607]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; inclusion body assembly [GO:0070841]; inflammatory response [GO:0006954]; interferon-mediated signaling pathway [GO:0140888]; maintenance of protein complex location [GO:0098544]; mucosal immune response [GO:0002385]; neuron apoptotic process [GO:0051402]; nucleotide transport [GO:0006862]; photoreceptor cell differentiation [GO:0046530]; protein aggregate center assembly [GO:0140454]; response to type III interferon [GO:0034342]; response to unfolded protein [GO:0006986]; toll-like receptor 9 signaling pathway [GO:0034162]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] AEFMCHMKPSER;ASRTKTK;AVLHVLKAKR;LGIWLFMSEMPFGTLSVQMLWK;NRAEFMCHMKPSER;SRLWQFKEEQMSVQGICADQVK;VNEDTQFHDDILLWLQKLVSVLQR 7 3.8 0.88213 -0.17558 11.3683 7.47873 8.8596 0 0 0 8.15173 0 10.9273 0 0 0 Q9HCE1 MOV10_HUMAN Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) MOV10 KIAA1631 Homo sapiens (Human) 3'-UTR-mediated mRNA destabilization [GO:0061158]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of neuron projection arborization [GO:0150011]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; transposable element silencing [GO:0010526]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; P granule [GO:0043186]; P-body [GO:0000932] 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723] LYDRSLESNPEQLQAMR;TVTLVEAIK 2 2.6 0.95721 -0.99772 0 0 0 0 0 0 0 10.764 0 0 0 0 Q9HCE3 ZN532_HUMAN Zinc finger protein 532 ZNF532 KIAA1629 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] EPQPVSK;KAASDSCKEPVANSR;LANNTTVK;LKESSDKVLENR;SMNGKEK;SPYTCPECGAICR;TSSGEIK;VQVVSSLQSSVVEAFNK;VYACSHCPDSR 9 7.5 0.97501 -3.8933 8.5979 10.7814 5.67872 0 0 0 9.49241 10.7759 7.38016 0 9.55723 0 Q9HCE5 MET14_HUMAN N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) METTL14 KIAA1627 Homo sapiens (Human) "forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA destabilization [GO:0061157]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of translation [GO:0045727]; regulation of neuron differentiation [GO:0045664]; response to nutrient levels [GO:0031667]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734] FEEYPKLRELIR 1 2.6 0.86835 -0.093442 0 0 0 0 0 1.89468 0 0 0 0 0 0 Q9HCE6 ARGAL_HUMAN Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) ARHGEF10L GRINCHGEF KIAA1626 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]; SREBP signaling pathway [GO:0032933] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] CQVVFFR;LFQELQDLQK;RHILGSIVQSEGSYVESLK;VYLGPPR 4 3.4 0.9538 -0.89435 0 0 0 0 9.47719 0 0 0 8.32984 10.2962 0 0 Q9HCE7 SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) SMURF1 KIAA1625 Homo sapiens (Human) "BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; ectoderm development [GO:0007398]; engulfment of target by autophagosome [GO:0061736]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein export from nucleus [GO:0006611]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; protein targeting to vacuole involved in autophagy [GO:0071211]; receptor catabolic process [GO:0032801]; substrate localization to autophagosome [GO:0061753]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] activin receptor binding [GO:0070697]; I-SMAD binding [GO:0070411]; phospholipid binding [GO:0005543]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DTGYQRLDLCK;HELSLQQPQAGHCR;IDLNDWK;LFTIHLIDANTDNLPKAHTCFNR 4 7.3 0.9539 -0.88907 0 0 0 0 0 0 0 0 0 6.76089 0 10.8906 Q9HCE9 ANO8_HUMAN Anoctamin-8 (Transmembrane protein 16H) ANO8 KIAA1623 TMEM16H Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229] FFTSQERQSIIRFWLQNLR;LEYQRREAFK;VGIPELIVQVRHHRHTR 3 3.7 0.94207 -0.59496 0 6.86716 0 0 0 0 0 0 0 11.58 0 10.889 Q9HCF6 TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; protein homotetramerization [GO:0051289]; zinc ion transmembrane transport [GO:0071577] plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; G-protein beta/gamma-subunit complex binding [GO:0031683]; monoatomic cation channel activity [GO:0005261]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ATSSHSVAKEPK;DPHRCCCGR;EILMSEPGK;INTRCLPFFSLDSR;IRVTSERVENMSMR;KLCHAAFLPSVR;KVHDFEEQCIEEYFR;LLTYELKNWSNATCLQLAVAAKHR;LSRNDIQSEK;SISNQVWK;TLYHNLFGPKRDDIPLR;VIYCVNIIYWYIR 12 9.1 0.97804 -6.1224 13.2585 0 0 9.72139 10.1901 0 10.5028 0 10.47 10.0014 11.2184 0 Q9HCG1 ZN160_HUMAN Zinc finger protein 160 (Zinc finger protein HZF5) (Zinc finger protein Kr18) (HKr18) ZNF160 KIAA1611 Homo sapiens (Human) hemopoiesis [GO:0030097]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HESPDIEDFSFK;SFTQKSHLRSHR;VFTQNAHLANHR;YNSYLGRHR 4 5.5 0.98034 -2.0382 0 0 0 0 6.56484 0 0 11.9637 0 0 8.12013 11.0579 Q9HCG7 GBA2_HUMAN Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase) GBA2 KIAA1605 SPG46 AD035 Homo sapiens (Human) bile acid metabolic process [GO:0008206]; carbohydrate metabolic process [GO:0005975]; central nervous system development [GO:0007417]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; lipid glycosylation [GO:0030259]; regulation of actin filament polymerization [GO:0030833]; regulation of membrane lipid distribution [GO:0097035]; regulation of microtubule polymerization [GO:0031113] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; steryl-beta-glucosidase activity [GO:0050295] ETDCCNPEDSGQLMVSYEGK 1 2.2 0.78303 0.025586 0 0 4.29976 0 0 0 0 0 0 0 0 0 Q9HCG8 CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) CWC22 KIAA1604 NCM Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] DRDYFDYSRSDYEHSR;FFGLLAGRFCMLK;LLKMEFPESQTK;LTQVSPRGINAIFERLR;MDPNFMENEEKYKAIK;QEHGHQETRTER;SYDSSMESR 7 10.5 0.97452 -3.5367 9.52683 0 0 8.57395 8.78702 0 0 0 0 0 0 0 Q9HCH0 NCK5L_HUMAN Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) NCKAP5L CEP169 KIAA1602 FP1193 Homo sapiens (Human) microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371] LPALNRR;QQEPGLMGDPGAR;RAHTLEREVPGIEELLVSGR;TREQEGVMWGDQFLQ 4 4.3 0.95921 -1.0375 0 0 8.25049 8.02109 0 0 0 0 11.1248 0 0 0 Q9HCH5 SYTL2_HUMAN Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) SYTL2 KIAA1597 SGA72M SLP2 SLP2A Homo sapiens (Human) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] "neurexin family protein binding [GO:0042043]; phosphatase binding [GO:0019902]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; small GTPase binding [GO:0031267]" QPIPLLMNKENSTK 1 1.1 0.82932 -0.021928 7.58991 0 0 0 0 0 0 0 0 0 0 0 Q9HCI5 MAGE1_HUMAN Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen) MAGEE1 HCA1 KIAA1587 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] ERRLSIFGNPK;LSIFGNPK 2 1.1 0.93627 -0.53386 0 0 0 2.28451 0 0 0 0 0 0 0 0 Q9HCI6 K1586_HUMAN E3 SUMO-protein ligase KIAA1586 (EC 2.3.2.-) (E3 SUMO-protein transferase KIAA1586) KIAA1586 Homo sapiens (Human) protein sumoylation [GO:0016925] SUMO ligase activity [GO:0061665] LLGTVAKELETEIIK;LQLSLDDSISEIK;STNIKKAQK 3 4.7 0.97522 -1.4546 0 6.9222 0 0 0 12.5695 11.4274 0 0 0 0 0 Q9HCI7 MSL2_HUMAN E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.27) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) MSL2 KIAA1585 MSL2L1 RNF184 Homo sapiens (Human) DNA damage response [GO:0006974]; epigenetic regulation of gene expression [GO:0040029]; positive regulation of DNA-templated transcription [GO:0045893]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567] chromatin [GO:0000785]; MSL complex [GO:0072487]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H2B ubiquitin ligase activity [GO:0141054]; metal ion binding [GO:0046872]; promoter-enhancer loop anchoring activity [GO:0140585]; ubiquitin protein ligase activity [GO:0061630] TVLLSTK 1 1.2 0.64167 0.17283 0 0 0 0 0 0 0 0 5.34703 0 0 0 Q9HCJ0 TNR6C_HUMAN Trinucleotide repeat-containing gene 6C protein TNRC6C KIAA1582 Homo sapiens (Human) "miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] RNA binding [GO:0003723] NVSGSMR;SGSGWNDTTR;VIIDRTDK 3 1.3 0.95554 -0.87212 0 0 0 10.7311 0 0 0 0 0 9.08228 0 0 Q9HCJ3 RAVR2_HUMAN Ribonucleoprotein PTB-binding 2 (Protein raver-2) RAVER2 KIAA1579 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] CFLVYSEVTGHSKGYGFVEYMKK 1 3.3 0.59379 0.17852 0 0 0 0 0 0 0 0 8.79951 0 0 0 Q9HCJ5 ZSWM6_HUMAN Zinc finger SWIM domain-containing protein 6 ZSWIM6 KIAA1577 Homo sapiens (Human) striatal medium spiny neuron differentiation [GO:0021773] Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] LQEIELDDTLVK;NIHSSSHIFK;VEERFERIPEPVQR 3 3 0.9155 -0.37626 0 4.48362 0 0 0 0 0 0 0 0 0 0 Q9HCJ6 VAT1L_HUMAN Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) VAT1L KIAA1576 Homo sapiens (Human) oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] AMPEPQDGELKIR 1 3.1 0.95334 -0.67615 0 0 0 0 10.2567 0 0 0 0 0 0 0 Q9HCK0 ZBT26_HUMAN Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref) ZBTB26 KIAA1572 ZNF481 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NDSTCVN;VESIGDVSEVR 2 4.1 0.95483 -0.83384 0 12.5791 0 0 0 10.0501 0 0 0 11.0404 0 0 Q9HCK1 ZDBF2_HUMAN DBF4-type zinc finger-containing protein 2 ZDBF2 KIAA1571 Homo sapiens (Human) genomic imprinting [GO:0071514] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AYDLRSSSCLQQR;CNLVDIGQATNNR;EFREGRFHCYFDDDCETK;EISLHTKEHMYLENK;EVNLSKEVRTDVQYK;EVRTDVQYK;GIFEDTIAK;IPGANKEINLLREEHVCLDDK;ISHSTQTSCK;ITFDSEQLQEAVKK;IVKPTDSR;LAVNPNK;LVLWKDVK;MVKYIDSEDK;RNWVKIHFNR;SAFLGRYLK;TAFWEQK;VDVDLENK 18 8.3 0.97859 -9.6035 7.13093 10.5365 9.96824 10.7637 0 0 9.5731 10.1346 11.4988 11.8294 11.6484 10.7072 Q9HCK4 ROBO2_HUMAN Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412] axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802] IDDKEERISIR;ISIRGGK;IVEHPSDVIVSK;TDLMGFGYSLPDQNKGNNGGK;TMSTDEGTYMCIAENR 5 4.6 0.97466 -2.4067 0 0 0 0 3.19238 8.28873 0 5.32955 0 8.76205 9.74662 8.65818 Q9HCK5 AGO4_HUMAN Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) AGO4 EIF2C4 KIAA1567 Homo sapiens (Human) male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; pre-miRNA processing [GO:0031054]; regulation of cell morphogenesis [GO:0022604]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; synaptonemal complex assembly [GO:0007130] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] EIRGLKVEVTHCGQMK;LVAFRARYHLVDK 2 3.4 0.95427 -0.93014 0 0 0 0 0 0 0 0 0 0 9.88855 0 Q9HCK8 CHD8_HUMAN Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) CHD8 HELSNF1 KIAA1564 Homo sapiens (Human) brain development [GO:0007420]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; single-stranded 3'-5' DNA helicase activity [GO:1990518] CVIIDEAHR;DRVLINRIDLVCQAVLSGK;IQSRHPELK;LEHEVVAR;LLDSLKHMDLEHK;LQAILKPMMLRR;LTFQKHK;QKWQRCK;TDESLTKYFHGFVAMCRQVCR 9 4.1 0.97514 -4.139 0 0 0 0 9.31354 9.96809 9.08836 0 0 11.7491 0 0 Q9HCL0 PCD18_HUMAN Protocadherin-18 PCDH18 KIAA1562 Homo sapiens (Human) brain development [GO:0007420]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FSLKDSGR;KGPLPAK;LSEDVADVLLK 3 2.3 0.96343 -1.0895 10.3041 0 0 7.72438 7.43946 0 0 0 6.5139 0 8.27459 0 Q9HCL3 ZFP14_HUMAN Zinc finger protein 14 homolog (Zfp-14) (Zinc finger protein 531) ZFP14 KIAA1559 ZNF531 Homo sapiens (Human) blastocyst hatching [GO:0001835]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFRVHQQLARHQR;VYECKECRK 2 4.1 0.90178 -0.26175 0 3.66471 0 0 0 0 0 0 0 6.81083 0 0 Q9HCM1 RESF1_HUMAN Retroelement silencing factor 1 RESF1 C12orf35 KIAA1551 Homo sapiens (Human) transposable element silencing by heterochromatin formation [GO:0141005] nucleus [GO:0005634] histone binding [GO:0042393]; histone methyltransferase binding [GO:1990226] KLYLNRVGFK 1 0.6 0.97921 -1.5336 0 0 0 0 0 0 0 0 0 14.0073 0 0 Q9HCM2 PLXA4_HUMAN Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; embryonic heart tube development [GO:0035050]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; maintenance of synapse structure [GO:0099558]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; synapse assembly [GO:0007416]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] DIPSYKNWVERYYSDIGK;ILVPVEVIKPITLKAK;LCKEDTAFNSYVEVPIGCER;LEDLFKLGEPYHKK;LQMQMDNLESR;MLTNWFTFLLYK;TESVAEK;VDKILVPVEVIKPITLK 8 5.3 0.97314 -2.869 0 6.68103 4.90939 6.9521 7.37565 0 5.03874 0 0 7.79103 4.43469 11.749 Q9HCM4 E41L5_HUMAN Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) EPB41L5 KIAA1548 Homo sapiens (Human) "actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm morphogenesis [GO:0048319]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826]" adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] cytoskeletal protein binding [GO:0008092]; protein domain specific binding [GO:0019904] FMDSAQVAHWLDGTKSIK;QKCLLTTEL 2 3.7 0.97827 -1.9773 0 0 5.27363 10.6466 0 0 0 0 0 0 0 0 Q9HCM7 FBSL_HUMAN Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) FBRSL1 AUTS2L KIAA1545 XTP9 Homo sapiens (Human) RNA binding [GO:0003723] AAPGDVK;ASPPHSK;DLLEKTRLLSR;DREPHGYSPERLR;GAPPRGAAPAPRTARPPR;YAPKLDSPYFR 6 6.4 0.97998 -1.6538 13.6224 10.185 12.7208 0 0 7.32382 0 0 8.11608 0 9.32427 0 Q9HCM9 TRI39_HUMAN E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39) TRIM39 RNF23 TFP Homo sapiens (Human) apoptotic process [GO:0006915]; innate immune response [GO:0045087]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DVKSTLEKNIPR 1 2.3 0.86867 -0.093677 0 0 0 0 0 0 0 0 0 7.84373 0 0 Q9HCN4 GPN1_HUMAN GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) GPN1 MBDIN RPAP4 XAB1 HUSSY-23 Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] AASAAAAELQASGGPR 1 4.3 0 7.2045 0 0 0 0 0 0 0 0 0 0 9.32227 0 Q9HCN4 GPN1_HUMAN GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) GPN1 MBDIN RPAP4 XAB1 HUSSY-23 Homo sapiens (Human) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGGARRK 1 1.8 0.83636 -0.030877 0 0 0 8.6851 0 0 0 0 0 0 0 0 Q9HCN6 GPVI_HUMAN Platelet glycoprotein VI (GPVI) (Glycoprotein 6) GP6 Homo sapiens (Human) collagen-activated signaling pathway [GO:0038065]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; enzyme-linked receptor protein signaling pathway [GO:0007167]; immune response-regulating signaling pathway [GO:0002764]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of platelet aggregation [GO:1901731] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197] collagen binding [GO:0005518]; collagen receptor activity [GO:0038064]; protein tyrosine kinase binding [GO:1990782]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] SPSPTALFCLGLCLGR 1 5 0.78066 0.033887 0 0 0 0 0 0 8.71977 0 0 0 0 0 Q9HCP0 KC1G1_HUMAN Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) CSNK1G1 Homo sapiens (Human) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] NLIYRDVKPENFLIGR 1 3.8 0.81192 -0.013481 0 7.53317 0 0 0 0 0 0 0 0 0 0 Q9HCP6 HHATL_HUMAN Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein) HHATL C3orf3 GUP1 KIAA1173 Homo sapiens (Human) negative regulation of N-terminal protein palmitoylation [GO:0060262] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] KAFRESVRPGWEYIGR 1 3.2 0.41345 0.20034 0 0 6.84887 0 0 0 0 0 0 0 0 0 Q9HCQ5 GALT9_HUMAN Polypeptide N-acetylgalactosaminyltransferase 9 (EC 2.4.1.41) (Polypeptide GalNAc transferase 9) (GalNAc-T9) (pp-GaNTase 9) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) GALNT9 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] KPYNNDIDYYAK 1 2 0.80725 0.01199 0 9.65978 0 0 0 0 0 0 0 0 0 0 Q9HCR9 PDE11_HUMAN "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)" PDE11A Homo sapiens (Human) cAMP-mediated signaling [GO:0019933]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165] cytosol [GO:0005829] "3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; metal ion binding [GO:0046872]" ITRLVQISGASLAEKQEK;LTGYKTKSLLCMPIR;LVQISGASLAEK;MVLYHNWR;NRKDELPR 5 7.2 0.97674 -4.8299 8.41578 0 10.2069 0 0 0 10.4144 0 0 0 0 0 Q9HCS2 CP4FC_HUMAN Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12) CYP4F12 UNQ568/PRO1129 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; monooxygenase activity [GO:0004497] FHRACRLVHDFTDAVIR 1 3.2 0.48534 0.18986 0 0 11.7327 0 0 0 8.68478 0 0 0 0 0 Q9HCS2 CP4FC_HUMAN Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12) CYP4F12 UNQ568/PRO1129 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; monooxygenase activity [GO:0004497] IISSSGS 1 6.9 0.82253 -0.017942 0 0 0 0 0 9.80348 0 0 9.79224 0 11.3851 0 Q9HCS5 E41LA_HUMAN Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) EPB41L4A EPB41L4 Homo sapiens (Human) actomyosin structure organization [GO:0031032] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] ELINTGPPYTLYFGIK;ETQFELRVLGKDCNETSFFFEAR;LTLTTQQQGIKK;TACKHLWK;TIKTIQASR 5 9.9 0.97467 -3.2409 10.1513 0 0 0 0 12.5695 10.2342 0 0 9.74806 0 11.9377 Q9HCS7 SYF1_HUMAN Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) XAB2 HCNP KIAA1177 SYF1 PP3898 Homo sapiens (Human) "blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]" catalytic step 2 spliceosome [GO:0071013]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] ATALPARR;FEQLISRRPLLLNSVLLR;LSPESAEEYIEYLK;LWCSLADYYIRSGHFEK;VALHQGRPR 5 7.7 0.97894 -1.9717 0 0 0 5.58445 3.82873 0 0 0 0 0 7.88972 0 Q9HCU0 CD248_HUMAN Endosialin (Tumor endothelial marker 1) (CD antigen CD248) CD248 CD164L1 TEM1 Homo sapiens (Human) anatomical structure regression [GO:0060033]; cell migration [GO:0016477]; endothelial cell apoptotic process [GO:0072577]; fibroblast migration [GO:0010761]; fibroblast proliferation [GO:0048144]; lymph node development [GO:0048535]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fibroblast proliferation [GO:0048146] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430] EDGPSPK 1 0.9 0.82295 -0.017923 0 0 0 0 0 0 0 0 0 0 0 9.21793 Q9HCU4 CELR2_HUMAN Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) "cell-cell adhesion [GO:0098609]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; motor neuron migration [GO:0097475]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] EGGYTCLCRDGYTGEHCEVSAR;GLRQRFHFTLALSFATK;LTLPEEHPCLKAPR;SFPAHSFITFRGLR;TRFGLPAAAPCPK 5 2.6 0.97418 -1.4042 0 0 10.5981 0 0 10.0147 0 0 0 9.18827 0 10.4824 Q9HCU5 SEC12_HUMAN Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein) PREB SEC12 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; lipoprotein transport [GO:0042953]; regulation of COPII vesicle coating [GO:0003400] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085] CGAETQHEGLELR 1 3.1 0.88194 -0.16403 0 0 10.7543 7.93322 7.46074 8.50263 0 9.71471 0 11.0498 0 0 Q9HCU8 DPOD4_HUMAN DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) POLD4 POLDS Homo sapiens (Human) DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of endothelial cell proliferation [GO:0001938] delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654] GELAPELGEEPQPR 1 13.1 0.8644 -0.085991 0 0 10.1475 0 0 0 0 12.2784 0 0 0 0 Q9HCU9 BRMS1_HUMAN Breast cancer metastasis-suppressor 1 BRMS1 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of anoikis [GO:2000210]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059] SECVSEMLDLEK 1 4.9 0.88136 -0.1705 0 0 0 0 0 0 0 0 0 0 12.2308 0 Q9HCX3 ZN304_HUMAN Zinc finger protein 304 (KRAB-containing zinc finger protein) ZNF304 Homo sapiens (Human) angiogenesis [GO:0001525]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FHTGERPYECSECGK;IHTGARPYECIECGK 2 4.6 0.44258 0.19336 0 0 4.75814 0 0 0 0 0 0 0 8.99161 0 Q9HCX4 TRPC7_HUMAN Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) TRPC7 TRP7 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; manganese ion transport [GO:0006828]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" TLPNETFTDYPKQIFRVK;YELLEEK 2 2.9 0.50701 0.1878 0 0 0 0 0 0 0 0 0 0 5.64685 0 Q9HCZ1 ZN334_HUMAN Zinc finger protein 334 ZNF334 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KIPDGYSGFGK;KIPDGYSGFGKHEK;QPFDYNK;SYECNECGK 4 5.7 0.91444 -0.33538 0 9.29756 7.08236 0 0 9.66945 8.8577 4.85868 5.62407 0 0 0 Q9HD20 AT131_HUMAN Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) ATP13A1 ATP13A KIAA1825 CGI-152 Homo sapiens (Human) extraction of mislocalized protein from ER membrane [GO:0140569]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] ABC-type manganese transporter activity [GO:0015410]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; membrane protein dislocase activity [GO:0140567]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662] DLEDESTPIVK;TILFGVK;VLALGYK 3 2.1 0.97339 -1.3775 0 11.3245 0 0 0 0 9.14603 8.94334 0 0 0 0 Q9HD23 MRS2_HUMAN "Magnesium transporter MRS2 homolog, mitochondrial (MRS2-like protein)" MRS2 HPT MRS2L Homo sapiens (Human) lactate metabolic process [GO:0006089]; mitochondrial magnesium ion transmembrane transport [GO:0045016]; transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] magnesium ion transmembrane transporter activity [GO:0015095] FDKQGNVTSFERK;MECLRSLPCLLPRAMR;SLPCLLPRAMR;SLPCLLPRAMRLPR 4 7.2 0.96361 -1.1116 4.42452 8.10234 0 0 0 0 0 0 0 8.90572 10.5979 0 Q9HD34 LYRM4_HUMAN LYR motif-containing protein 4 LYRM4 C6orf149 ISD11 CGI-203 Homo sapiens (Human) [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron-sulfur cluster assembly [GO:0016226] iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803] AASSRAQVLSLYRAMLR;LIIENRDMPR;LIIENRDMPRT 3 30.8 0.95488 -0.9457 9.81718 0 4.06635 0 0 8.08948 10.7589 0 0 10.5482 0 0 Q9HD36 B2L10_HUMAN Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein Boo) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B) BCL2L10 BCL-B BCLB BOO DIVA Homo sapiens (Human) apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female gamete generation [GO:0007292]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; microtubule organizing center organization [GO:0031023]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; release of cytochrome c from mitochondria [GO:0001836]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; spindle [GO:0005819] calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; channel activity [GO:0015267] TPFPLAFWRKQLVQAFLSCLLTTAFIYLWTR 1 15.2 0.87125 -0.10178 0 11.4848 0 0 0 0 0 0 0 0 0 0 Q9HD40 SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein) SEPSECS TRNP48 Homo sapiens (Human) conversion of seryl-tRNAsec to selenocys-tRNAsec [GO:0001717]; selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] O-phosphoseryl-tRNA(Sec) selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049] ESDDNYDK;LVSPAYVRQGCEAR 2 4.4 0.94006 -0.57949 0 0 0 10.1329 0 0 5.53813 0 0 0 0 0 Q9HD42 CHM1A_HUMAN Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of gene expression [GO:0010629]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] MDDTLFQLK;VQTAVTMKGVTKNMAQVTK;VYAENAIR 3 18.4 0 2.0549 0 0 0 0 0 0 0 0 0 10.7453 8.49657 0 Q9HD45 TM9S3_HUMAN Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein) TM9SF3 SMBP UNQ245/PRO282 Homo sapiens (Human) protein localization to membrane [GO:0072657] membrane [GO:0016020] KSDVKFEDR 1 1.5 0.82606 -0.02003 0 0 0 0 0 0 10.623 0 0 0 0 0 Q9HD67 MYO10_HUMAN Unconventional myosin-X (Unconventional myosin-10) MYO10 KIAA0799 Homo sapiens (Human) cytoskeleton-dependent intracellular transport [GO:0030705]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; plus-end directed microfilament motor activity [GO:0060002]; spectrin binding [GO:0030507]" EVKNSPK;KGGGSSTLSRR;LILKFLSVISQQSLELSLKEK;REEEERER;RHDNQCILISGESGAGK 5 3.1 0.97995 -2.0028 0 10.1233 0 0 0 0 0 11.7855 9.73113 0 9.36304 0 Q9HD89 RETN_HUMAN Resistin (Adipose tissue-specific secretory factor) (ADSF) (C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein) (Cysteine-rich secreted protein A12-alpha-like 2) (Cysteine-rich secreted protein FIZZ3) RETN FIZZ3 HXCP1 RSTN UNQ407/PRO1199 Homo sapiens (Human) fat cell differentiation [GO:0045444]; negative regulation of feeding behavior [GO:2000252]; positive regulation of progesterone secretion [GO:2000872]; positive regulation of synaptic transmission [GO:0050806]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580] hormone activity [GO:0005179] ALCLLLLPVLGLLVSSKTLCSMEEAINER;KALCLLLLPVLGLLVSSK 2 36.6 0.44671 0.19275 7.57001 6.4162 2.62471 0 8.02796 0 8.30063 7.31786 0 0 0 0 Q9HD90 NDF4_HUMAN Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3) NEUROD4 ATH3 ATOH3 BHLHA4 Homo sapiens (Human) amacrine cell differentiation [GO:0035881]; axon development [GO:0061564]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; motor neuron migration [GO:0097475]; neuroblast proliferation [GO:0007405]; Notch signaling pathway [GO:0007219]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" GLGSQNEVK;RVMPCYSKTQK 2 6 0.91669 -0.41464 0 0 0 0 0 0 0 0 0 13.6732 6.04463 0 Q9HDB9 GAK5_HUMAN Endogenous retrovirus group K member 5 Gag polyprotein (HERV-K(II) Gag protein) (HERV-K_3q12.3 provirus ancestral Gag polyprotein) (Gag polyprotein) ERVK-5 ERVK5 Homo sapiens (Human) viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] TLLDSIAHGNR 1 1.6 0.94091 -0.59134 0 0 0 0 0 0 0 0 0 0 11.4427 0 Q9HDC5 JPH1_HUMAN Junctophilin-1 (JP-1) (Junctophilin type 1) JPH1 JP1 Homo sapiens (Human) calcium ion transport into cytosol [GO:0060402]; muscle organ development [GO:0007517]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314] endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018] structural constituent of muscle [GO:0008307] HGYGCTVFPDGSK 1 2 0.78953 0.017135 0 0 0 0 0 0 0 0 0 0 5.97088 0 Q9HDC9 APMAP_HUMAN Adipocyte plasma membrane-associated protein (Protein BSCv) APMAP C20orf3 UNQ1869/PRO4305 Homo sapiens (Human) biosynthetic process [GO:0009058] cell surface [GO:0009986]; membrane [GO:0016020] arylesterase activity [GO:0004064]; strictosidine synthase activity [GO:0016844] FGSGPCK;IYFTDSSSKWQR 2 4.6 0.95694 -1.023 0 0 0 0 0 0 0 0 9.39197 9.2056 0 0 Q9NNW5 WDR6_HUMAN tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) WDR6 Homo sapiens (Human) G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; tRNA methylation [GO:0030488]; wobble position ribose methylation [GO:0002130] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] enzyme regulator activity [GO:0030234]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] DGQLQPVLR;GLLATASEDRSVR 2 2 0.9558 -0.98352 0 0 0 0 0 0 0 0 0 12.2175 0 0 Q9NNW7 TRXR2_HUMAN "Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)" TXNRD2 KIAA1652 TRXR2 Homo sapiens (Human) cell redox homeostasis [GO:0045454]; response to hyperoxia [GO:0055093]; response to oxygen radical [GO:0000305]; response to selenium ion [GO:0010269]; response to xenobiotic stimulus [GO:0009410] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] flavin adenine dinucleotide binding [GO:0050660]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] GAAAGQR;WRTQAVAGGVRGAAR 2 4.2 0.96542 -1.2423 0 0 0 0 0 0 0 0 8.34354 0 0 0 Q9NNX1 TUFT1_HUMAN Tuftelin TUFT1 Homo sapiens (Human) bone mineralization [GO:0030282]; odontogenesis [GO:0042476] cytoplasm [GO:0005737]; extracellular region [GO:0005576] structural constituent of skin epidermis [GO:0030280]; structural constituent of tooth enamel [GO:0030345] MIHEKNINQLKSEVQYIQEAR;NINQLKSEVQYIQEAR;RQHQSDCVAFEVTLSRYQR 3 10.3 0.91401 -0.32991 8.73223 0 0 0 0 0 0 5.10131 9.86292 0 0 0 Q9NNX6 CD209_HUMAN CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) CD209 CLEC4L Homo sapiens (Human) adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; B cell adhesion [GO:0097323]; cell-cell recognition [GO:0009988]; endocytosis [GO:0006897]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of viral life cycle [GO:1903902]; regulation of T cell proliferation [GO:0042129]; symbiont entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; peptide antigen binding [GO:0042605]; virion binding [GO:0046790]; virus receptor activity [GO:0001618] CNLAKFWICKK 1 2.7 0.60235 0.17769 0 0 5.87113 0 0 0 0 0 0 0 0 0 Q9NNZ3 DNJC4_HUMAN DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18) DNAJC4 HSPF2 MCG18 Homo sapiens (Human) protein folding [GO:0006457]; response to unfolded protein [GO:0006986] membrane [GO:0016020] unfolded protein binding [GO:0051082] SYDDQLR 1 2.9 0.71324 0.14842 0 0 0 0 0 0 0 0 0 9.67786 9.82453 0 Q9NP08 HMX1_HUMAN Homeobox protein HMX1 (Homeobox protein H6) HMX1 H6 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" EDEEEDDDDPEDEDAEQAR 1 5.5 0.78349 0.020852 0 0 0 5.23408 0 0 0 0 0 0 0 0 Q9NP31 SH22A_HUMAN SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) SH2D2A SCAP TSAD VRAP Homo sapiens (Human) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098] cytoplasm [GO:0005737]; cytosol [GO:0005829] SH3 domain binding [GO:0017124] FSESAVTFVLTYR 1 3.3 0.8021 0.014412 0 0 11.3853 0 0 0 0 0 0 0 0 0 Q9NP50 SHCAF_HUMAN SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog) SINHCAF C12orf14 FAM60A L4 Homo sapiens (Human) negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459] nucleus [GO:0005634]; Sin3-type complex [GO:0070822] EFKRHNSDAHSTTSSASPAQSPCYSNQSDDGSDTEMASGSNR;MFGFHKPK;TPVFSFLDLTYWK 3 28.5 0.89655 -0.23007 0 0 0 0 0 0 10.6321 9.66589 0 10.5953 0 0 Q9NP55 BPIA1_HUMAN BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl) BPIFA1 LUNX NASG PLUNC SPLUNC1 SPURT UNQ787/PRO1606 Homo sapiens (Human) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to virus [GO:0051607]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; innate immune response [GO:0045087]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; regulation of sodium ion transmembrane transport [GO:1902305]; surfactant homeostasis [GO:0043129] extracellular region [GO:0005576]; extracellular space [GO:0005615] lipid binding [GO:0008289] GLDITLVHDIVNMLIHGLQFVIK 1 9 0.70241 0.16126 0 0 0 0 0 4.64253 0 0 0 0 0 0 Q9NP56 PDE7B_HUMAN "3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B)" PDE7B Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; chemical synaptic transmission [GO:0007268]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" QWSERVCEEFYRQGELEQK 1 4.2 0.49485 0.1893 0 0 0 0 0 0 0 0 0 9.20281 0 0 Q9NP58 ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter) ABCB6 MTABC3 PRP UMAT Homo sapiens (Human) brain development [GO:0007420]; cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transmembrane transport [GO:0035351]; heme transport [GO:0015886]; intracellular copper ion homeostasis [GO:0006878]; intracellular iron ion homeostasis [GO:0006879]; melanosome assembly [GO:1903232]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; skin development [GO:0043588]; tetrapyrrole metabolic process [GO:0033013]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] ABC-type heme transporter activity [GO:0015439]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; heme binding [GO:0020037]; tetrapyrrole binding [GO:0046906] AIQASLAK;KLRLLSGYLWPR 2 2.4 0.059222 0.44391 0 0 0 0 0 0 7.13289 9.89198 0 0 0 10.3711 Q9NP59 S40A1_HUMAN Ferroportin (Ferroportin-1) (Iron-regulated transporter 1) (Solute carrier family 40 member 1) SLC40A1 FPN FPN1 IREG1 SLC11A3 MSTP079 Homo sapiens (Human) apoptotic process [GO:0006915]; endothelium development [GO:0003158]; establishment of localization in cell [GO:0051649]; intracellular iron ion homeostasis [GO:0006879]; iron ion export across plasma membrane [GO:1903988]; iron ion transmembrane transport [GO:0034755]; lymphocyte homeostasis [GO:0002260]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spleen trabecula formation [GO:0060345]; transcription by RNA polymerase II [GO:0006366] basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; iron ion transmembrane transporter activity [GO:0005381]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046] AGDHNRQR 1 1.4 0.91285 -0.33804 0 0 0 0 0 0 0 0 0 7.35129 0 0 Q9NP60 IRPL2_HUMAN X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1) IL1RAPL2 IL1R9 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; regulation of presynapse assembly [GO:1905606] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] "interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" EISCPDMDDFKK;IRYLEKSEVTK;LMWYKNKGDLEEPIIFSEVR;SIKLLSLIKWK;TYMALAGEPVR 5 9.5 0.97793 -2.1554 7.15532 0 0 6.66633 0 0 0 0 9.22658 0 0 10.5516 Q9NP61 ARFG3_HUMAN ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) ARFGAP3 ARFGAP1 Homo sapiens (Human) COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AAQLYREKIK 1 1.9 0.76698 0.059369 0 0 0 0 0 0 0 0 0 7.54024 0 0 Q9NP64 ZCC17_HUMAN Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) ZCCHC17 PS1D HSPC243 HSPC251 LDC4 Homo sapiens (Human) RNA stabilization [GO:0043489] cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] KQLIEDTEKNK 1 4.7 0.27893 0.25404 0 0 0 0 0 0 0 0 0 10.6212 0 0 Q9NP66 HM20A_HUMAN High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) HMG20A HMGX1 HMGXB1 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] ELEQYQK;YLDEADRDKER 2 5.2 0.953 -0.73583 0 0 0 0 0 0 4.62848 0 0 0 0 0 Q9NP70 AMBN_HUMAN Ameloblastin AMBN Homo sapiens (Human) biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of cell population proliferation [GO:0042127] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] growth factor activity [GO:0008083]; structural constituent of tooth enamel [GO:0030345] SASKIPLFK 1 2 0.98041 -1.5736 0 0 7.31034 0 0 0 0 0 0 0 0 0 Q9NP71 MLXPL_HUMAN Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) MLXIPL BHLHD14 MIO WBSCR14 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; triglyceride homeostasis [GO:0070328] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" KPEAVVLEGNYWKRR 1 1.8 0.9652 -1.1489 0 10.1209 0 0 0 0 0 0 0 0 0 0 Q9NP72 RAB18_HUMAN Ras-related protein Rab-18 RAB18 Homo sapiens (Human) brain development [GO:0007420]; endoplasmic reticulum tubular network organization [GO:0071786]; eye development [GO:0001654]; intracellular protein transport [GO:0006886]; lipid droplet organization [GO:0034389]; small GTPase-mediated signal transduction [GO:0007264] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] TISVDGNK 1 3.9 0.91363 -0.39033 0 0 0 0 0 0 0 8.66676 0 0 0 0 Q9NP73 ALG13_HUMAN UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) ALG13 CXorf45 GLT28D1 MDS031 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; proteolysis [GO:0006508] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; UDP-N-acetylglucosamine transferase complex [GO:0043541] cysteine-type deubiquitinase activity [GO:0004843]; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [GO:0004577] CCQSYDNFSYR;CCQSYDNFSYRSR;LILQIGRGTVVPEPFSTESFTLDVYR;QQKKMFK 4 4 0.95432 -0.89808 0 7.02967 0 0 0 0 3.72432 0 9.89404 0 0 0 Q9NP78 ABCB9_HUMAN ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL) ABCB9 KIAA1520 Homo sapiens (Human) peptide metabolic process [GO:0006518]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020] ABC-type oligopeptide transporter activity [GO:0015421]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857] KLQQVYKLNR;LSTVEHAHLIVVLDK;NSALGPR;VFEFIDR 4 5.1 0.88081 -0.16998 0 0 11.4268 8.17498 0 0 7.7021 9.73618 0 0 0 0 Q9NP79 VTA1_HUMAN Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) VTA1 C6orf55 HSPC228 My012 Homo sapiens (Human) ESCRT III complex disassembly [GO:1904903]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654] AALAPLPPLPAQFK;IDSKTPECR;LLTTGRE;LTPEDFAR 4 12.4 0.004662 1.3539 0 0 0 8.43917 8.37391 8.68338 9.47502 0 11.7608 8.46516 0 10.6383 Q9NP80 PLPL8_HUMAN Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) PNPLA8 IPLA22 IPLA2G BM-043 Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; cardiolipin metabolic process [GO:0032048]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; linoleic acid metabolic process [GO:0043651]; lipid homeostasis [GO:0055088]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to oxidative stress [GO:1900407]; triglyceride homeostasis [GO:0070328] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ATP binding [GO:0005524]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970] GLTKVNICMSR;ILSIDGGGTRGVVALQTLRK;LSTSAPK;VAKILSQEK;VSDSGWLKQKNIK 5 7.7 0.97482 -3.6863 11.3158 0 0 0 0 0 10.3058 0 0 6.83188 5.47388 0 Q9NP81 SYSM_HUMAN "Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" SARS2 SARSM Homo sapiens (Human) mitochondrial seryl-tRNA aminoacylation [GO:0070158]; seryl-tRNA aminoacylation [GO:0006434] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049] GLYRVHHFTK;LLIALLESNQQK;LLRRGFTPMTVPDLLR;SFTTEKRNR 4 9.1 0.98113 -2.0282 0 11.5431 0 0 0 9.59898 0 10.2935 0 0 0 0 Q9NP84 TNR12_HUMAN Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266) TNFRSF12A FN14 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of wound healing [GO:0061041] plasma membrane [GO:0005886] CMDCASCR;LLRLLVLGLWLALLR;LLVLGLWLALLR;RLLRLLVLGLWLALLR 4 18.6 0.89191 -0.21431 0 4.32157 7.50128 0 0 0 5.19763 0 0 0 5.80157 3.58376 Q9NP85 PODO_HUMAN Podocin NPHS2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; gene expression [GO:0010467]; glomerular filtration [GO:0003094]; metanephric podocyte development [GO:0072249] cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057] AGTPGEPRAPAATVVDVDEVR;SLTEILLERKSIAQDAK 2 9.9 0.91977 -0.43845 0 0 0 0 0 0 0 11.0027 0 0 10.8572 0 Q9NP87 DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) POLM polmu Homo sapiens (Human) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] AAPPGPEHPSPAVRCR;TADRWYREGLR 2 5.9 0.93615 -0.51845 0 11.4869 0 0 0 0 0 0 0 0 11.1594 0 Q9NP87 DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) POLM polmu Homo sapiens (Human) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] SCFCCRRHFSK 1 2.2 0.76768 0.058397 0 0 0 0 0 0 0 0 0 0 0 7.88423 Q9NP91 S6A20_HUMAN Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog) SLC6A20 SIT1 XT3 XTRP3 Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; L-isoleucine import across plasma membrane [GO:1903806]; L-proline import across plasma membrane [GO:1904271]; proline import across plasma membrane [GO:1905647]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-proline transmembrane transporter activity [GO:0015193]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; proline:sodium symporter activity [GO:0005298]; solute:sodium symporter activity [GO:0015370] AVSWYWK 1 1.2 0.92981 -0.46597 9.41747 0 0 0 0 0 0 0 0 0 0 0 Q9NP92 RT30_HUMAN "Large ribosomal subunit protein mL65 (39S ribosomal protein S30, mitochondrial) (MRP-S30) (S30mt) (Large ribosomal subunit protein mS30) (Programmed cell death protein 9)" MRPS30 PDCD9 BM-047 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AAARCWRPLLRGPR;ILTKMQFMK 2 5.2 0.91607 -0.35098 0 0 0 3.38654 0 0 0 0 0 8.61673 0 0 Q9NP97 DLRB1_HUMAN "Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)" DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162 Homo sapiens (Human) microtubule-based movement [GO:0007018]; visual behavior [GO:0007632] centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874] dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777] MAEVEETLK 1 9.4 0.90958 -0.31545 0 0 9.15517 0 0 0 0 9.68089 0 0 0 0 Q9NP98 MYOZ1_HUMAN "Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ)" MYOZ1 MYOZ Homo sapiens (Human) myofibril assembly [GO:0030239]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of skeletal muscle tissue regeneration [GO:0043417]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; Z disc [GO:0030018] actin binding [GO:0003779]; actinin binding [GO:0042805]; FATZ binding [GO:0051373]; molecular condensate scaffold activity [GO:0140693]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; telethonin binding [GO:0031433] TYISPWER 1 2.7 0.91469 -0.39033 0 0 0 0 0 0 0 10.3492 0 0 0 0 Q9NPA0 EMC7_HUMAN Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7) EMC7 C11orf3 C15orf24 HT022 UNQ905/PRO1926 Homo sapiens (Human) protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] carbohydrate binding [GO:0030246] SSSGSSK 1 2.9 0.82353 -0.017959 0 0 0 0 0 0 0 0 0 0 9.66208 0 Q9NPA2 MMP25_HUMAN Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP) MMP25 MMP20 MMPL1 MT6MMP Homo sapiens (Human) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; inflammatory response [GO:0006954]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LLALLLLLLAPPAR;VVQAAYARHRDGR 2 4.8 0.97993 -1.5481 12.0888 0 0 0 0 0 0 0 0 0 0 0 Q9NPA8 ENY2_HUMAN Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) ENY2 DC6 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of DNA-templated transcription [GO:0045893]; protein transport [GO:0015031]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] DUBm complex [GO:0071819]; mitochondrion [GO:0005739]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription export complex 2 [GO:0070390]; transcription factor TFTC complex [GO:0033276] chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713] TFLAQHASL 1 8.9 0.8323 -0.028647 0 11.7343 0 0 0 9.8614 0 0 0 0 0 0 Q9NPB1 NT5M_HUMAN "5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)" NT5M DNT2 Homo sapiens (Human) DNA replication [GO:0006260]; dUMP catabolic process [GO:0046079]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; nucleotide binding [GO:0000166] LGGWCARR;MIRLGGWCAR 2 4.8 0.95436 -0.95907 8.08598 0 0 0 0 0 0 0 0 0 0 0 Q9NPB6 PAR6A_HUMAN Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) PARD6A PAR6A Homo sapiens (Human) cell division [GO:0051301]; cell-cell junction maintenance [GO:0045217]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein secretion [GO:0050714]; regulation of cellular localization [GO:0060341]; viral process [GO:0016032] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight junction [GO:0070160] GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267] KGLLLRPVAPLR 1 3.5 0.73915 0.10296 0 0 0 0 3.83582 0 0 0 0 0 0 0 Q9NPB8 GPCP1_HUMAN Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519] cytosol [GO:0005829] glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070] IVFSSFDADICTMVRQKQNK 1 3 0.96343 -1.1059 0 0 0 9.23475 0 0 0 0 0 0 0 0 Q9NPB9 ACKR4_HUMAN Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR) ACKR4 CCBP2 CCR11 CCRL1 VSHK1 Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044] TLMKMPNIK 1 2.6 0.93315 -0.49595 0 0 0 0 0 0 0 0 0 0 8.63321 0 Q9NPC6 MYOZ2_HUMAN Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) MYOZ2 C4orf5 Homo sapiens (Human) negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; sarcomere [GO:0030017]; Z disc [GO:0030018] actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein phosphatase 2B binding [GO:0030346]; telethonin binding [GO:0031433] DIMLEELSHLSNR 1 4.9 0.68094 0.16487 0 0 0 0 0 0 0 0 0 0 7.83517 0 Q9NPC7 MYNN_HUMAN Myoneurin (Zinc finger and BTB domain-containing protein 31) MYNN OSZF ZBTB31 SBBIZ1 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KSSQTKK;SFISSGELNK 2 2.8 0.93742 -0.54054 0 0 0 0 0 0 0 0 0 0 0 9.39358 Q9NPD3 EXOS4_HUMAN Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) EXOSC4 RRP41 SKI6 Homo sapiens (Human) defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475] cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; intracellular membrane-bounded organelle [GO:0043231]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723] AGLELLSDQGYRVDGR;VLEAAAQAAR 2 10.6 0.94396 -0.6341 0 0 0 0 4.35283 0 0 8.43784 0 0 0 0 Q9NPD5 SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] DQHQHLNK;IVQPELKALAMGFQSMVIR;TCMKWSTNSCGAQGACR;VALIFPVLVLLTVFIFVVR;VALIFPVLVLLTVFIFVVRK;VALIFPVLVLLTVFIFVVRKK 6 8.7 0.81424 -0.0055286 9.60045 9.12879 0 0 6.01509 5.42489 0 6.8902 3.39328 0 10.217 0 Q9NPE2 NGRN_HUMAN Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G) NGRN FI58G HT020 Homo sapiens (Human) mitochondrial ribosome assembly [GO:0061668]; neuron differentiation [GO:0030182]; positive regulation of mitochondrial translation [GO:0070131] extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; rRNA binding [GO:0019843] AGLAHSLQHLRGSGNTSK 1 6.2 0.91778 -0.43488 0 11.5641 0 0 0 0 0 0 0 0 0 0 Q9NPF0 CD320_HUMAN CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) CD320 8D6A UNQ198/PRO224 Homo sapiens (Human) B cell costimulation [GO:0031296]; cobalamin transport [GO:0015889]; positive regulation of B cell proliferation [GO:0030890]; regulation of vitamin metabolic process [GO:0030656]; ventral spinal cord development [GO:0021517] caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; growth factor activity [GO:0008083] DLDCSDGSDEEECR 1 5 0.69206 0.16227 6.35646 0 0 0 0 0 0 0 0 0 0 0 Q9NPF2 CHSTB_HUMAN Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) CHST11 Homo sapiens (Human) apoptotic process [GO:0006915]; carbohydrate biosynthetic process [GO:0016051]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic viscerocranium morphogenesis [GO:0048703]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell population proliferation [GO:0042127]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179] Golgi membrane [GO:0000139]; membrane [GO:0016020] chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; sulfotransferase activity [GO:0008146] KPALLEVMRMNRICR;SYMKFLFVREPFER 2 8.4 0.9777 -2.166 0 0 0 0 0 0 0 9.09534 0 0 0 11.9419 Q9NPF4 OSGEP_HUMAN tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) OSGEP GCPL1 Homo sapiens (Human) tRNA modification [GO:0006400]; tRNA threonylcarbamoyladenosine modification [GO:0002949] cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711] ISNDPSPGYNIEQMAK 1 4.8 0.78531 0.029414 0 0 0 0 0 0 10.2823 0 0 0 0 0 Q9NPF5 DMAP1_HUMAN DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) DMAP1 KIAA1425 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; Swr1 complex [GO:0000812] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] DGAMFFHWR;DILELGGPEGDAASGTISKKDIINPDK;ESASSSSSVKKAK;FDLRFVVIHDRYDHQQFK;RSQDLQKLITAADTTAEQR 5 18.4 0.98087 -1.6245 0 9.91677 0 0 0 0 4.88069 0 0 0 12.3005 0 Q9NPF8 ADAP2_HUMAN Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2) ADAP2 CENTA2 Homo sapiens (Human) heart development [GO:0007507] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial envelope [GO:0005740]; plasma membrane [GO:0005886] "GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]" VPAFYYIPQANDCLVLKEQWIRAK 1 6.3 0.62459 0.1736 0 4.94143 0 0 0 0 0 0 9.8913 0 0 0 Q9NPG1 FZD3_HUMAN Frizzled-3 (Fz-3) (hFz3) FZD3 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; commissural neuron axon guidance [GO:0071679]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; motor neuron migration [GO:0097475]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of neuroblast proliferation [GO:0002052]; post-anal tail morphogenesis [GO:0036342]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; serotonergic neuron axon guidance [GO:0036515]; sympathetic ganglion development [GO:0061549]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] IEIPLEK;WGSEAIEKK 2 2.4 0.95391 -0.89603 0 0 0 0 0 0 0 0 0 0 0 11.4575 Q9NPG4 PCD12_HUMAN "Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]" PCDH12 UNQ395/PRO731 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; glycogen metabolic process [GO:0005977]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; labyrinthine layer development [GO:0060711]; neuron recognition [GO:0008038] cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LSQELGREERR 1 0.9 0.9578 -1.0191 0 0 0 0 0 0 0 0 11.2833 0 0 0 Q9NPG8 ZDHC4_HUMAN Palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) (Zinc finger protein 374) ZDHHC4 ZNF374 DC1 UNQ5787/PRO19576 Homo sapiens (Human) positive regulation of innate immune response [GO:0045089]; protein localization to plasma membrane [GO:0072659]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] GGAQIFSCIIPECLQR 1 4.7 0.87389 -0.1184 0 0 0 0 0 0 0 0 9.93038 0 0 0 Q9NPH0 PPA6_HUMAN "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)" ACP6 ACPL1 LPAP UNQ205/PRO231 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; lysobisphosphatidic acid metabolic process [GO:2001311]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acid phosphatase activity [GO:0003993]; lysophosphatidic acid phosphatase activity [GO:0052642] MIEQRAVDTSLYILPK;VGMQQMFALGERLR 2 7 0.95146 -0.69353 0 0 0 0 8.82018 10.0753 0 0 0 0 0 0 Q9NPH2 INO1_HUMAN Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1) ISYNA1 INO1 Homo sapiens (Human) inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654] cytoplasm [GO:0005737]; cytosol [GO:0005829] inositol-3-phosphate synthase activity [GO:0004512] VFVGGDDFK;VFVGGDDFKSGQTK 2 2.5 0.95229 -0.7564 10.8775 2.52316 0 0 0 0 0 0 0 0 0 0 Q9NPH3 IL1AP_HUMAN Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) IL1RAP C3orf13 IL1R3 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of synapse assembly [GO:0051965]; protein-containing complex assembly [GO:0065003]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] cell surface [GO:0009986]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886] "coreceptor activity [GO:0015026]; interleukin-1 receptor activity [GO:0004908]; interleukin-33 receptor activity [GO:0002114]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" LYIEYGIQR;TVLTVIK 2 2.8 0.73946 0.10439 0 0 0 0 0 0 4.28703 0 0 6.98743 0 0 Q9NPH5 NOX4_HUMAN NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) NOX4 RENOX Homo sapiens (Human) bone resorption [GO:0045453]; cardiac muscle cell differentiation [GO:0055007]; cell morphogenesis [GO:0000902]; cellular response to glucose stimulus [GO:0071333]; defense response [GO:0006952]; gene expression [GO:0010467]; heart process [GO:0003015]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; reactive oxygen species biosynthetic process [GO:1903409]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; NADPH oxidase complex [GO:0043020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; modified amino acid binding [GO:0072341]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; nucleotide binding [GO:0000166]; oxygen sensor activity [GO:0019826]; protein tyrosine kinase binding [GO:1990782]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] LFIGRPR 1 1.2 0.90829 -0.30954 0 0 0 0 8.90932 0 0 0 0 0 0 0 Q9NPH6 OBP2B_HUMAN Odorant-binding protein 2b (Odorant-binding protein IIb) (OBPIIb) OBP2B UNQ653/PRO1283 Homo sapiens (Human) chemosensory behavior [GO:0007635]; sensory perception of smell [GO:0007608] extracellular space [GO:0005615] odorant binding [GO:0005549]; small molecule binding [GO:0036094] DFPEDRRPRK;TEEPGKYSAYGGR 2 13.5 0.88557 -0.18211 0 0 0 0 0 0 7.25588 0 0 8.82197 0 0 Q9NPH6 OBP2B_HUMAN Odorant-binding protein 2b (Odorant-binding protein IIb) (OBPIIb) OBP2B UNQ653/PRO1283 Homo sapiens (Human) chemosensory behavior [GO:0007635]; sensory perception of smell [GO:0007608] extracellular space [GO:0005615] odorant binding [GO:0005549]; small molecule binding [GO:0036094] DFPEDRRPRK;IGTRRPR 2 10.3 0.96698 -1.2941 8.24213 11.5112 0 8.62055 9.37258 8.28628 0 0 0 9.71019 0 0 Q9NPH9 IL26_HUMAN Interleukin-26 (IL-26) (Protein AK155) IL26 AK155 Homo sapiens (Human) cell-cell signaling [GO:0007267]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125] KIRFVEDFHSLR;LSHCISCASSAR;LVNFILRCGLLLVTLSLAIAK 3 26.3 0.97691 -1.495 0 0 0 9.49663 6.85312 0 0 9.16085 0 0 0 0 Q9NPI0 TM138_HUMAN Transmembrane protein 138 TMEM138 HSPC196 HSPC198 Homo sapiens (Human) cilium assembly [GO:0060271] cilium [GO:0005929]; vacuolar membrane [GO:0005774] DYCPCPC;NRRDYCPCPC 2 5.6 0.92238 -0.44321 0 0 5.67748 0 0 6.64645 0 0 0 0 0 0 Q9NPI1 BRD7_HUMAN Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) BRD7 BP75 CELTIX1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586] histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; p53 binding [GO:0002039]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] LLHSGMKILSQERIQSLK 1 2.8 0.54756 0.18358 0 0 0 0 0 0 0 0 0 8.38823 0 0 Q9NPI5 NRK2_HUMAN Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2) NMRK2 ITGB1BP3 NRK2 Homo sapiens (Human) NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; negative regulation of myoblast differentiation [GO:0045662] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nicotinate riboside kinase activity [GO:0034317]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769] APLFQPQDQIAVGEDGFK;RYFLTVPYEECKWR 2 13.6 0.84735 -0.064889 0 0 0 0 0 0 9.39857 0 0 7.91061 0 0 Q9NPI6 DCP1A_HUMAN mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) DCP1A SMIF Homo sapiens (Human) "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; mRNA methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein localization to cytoplasmic stress granule [GO:1903608]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; mRNA binding [GO:0003729] NSTMMQAVK 1 1.5 0.91076 -0.3191 0 0 8.51211 0 0 0 0 0 0 0 0 7.5672 Q9NPJ1 MKKS_HUMAN Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin) MKKS BBS6 Homo sapiens (Human) artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0060271]; convergent extension involved in gastrulation [GO:0060027]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; determination of left/right symmetry [GO:0007368]; developmental process [GO:0032502]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; gonad development [GO:0008406]; heart development [GO:0007507]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of stress fiber assembly [GO:0051492]; response to inositol [GO:1902140]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; vasodilation [GO:0042311]; visual perception [GO:0007601] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; motile cilium [GO:0031514]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; unfolded protein binding [GO:0051082] LLPIKKSTALK;SRLEAKKPSLCK 2 4 0.88715 -0.19085 0 0 0 0 10.2339 3.08275 0 0 0 0 0 0 Q9NPJ6 MED4_HUMAN Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36) MED4 ARC36 DRIP36 VDRIP HSPC126 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LLSALEDLEVLSR 1 4.8 0.9377 -0.56884 0 0 0 8.97011 0 0 0 0 0 8.49957 0 0 Q9NPL8 TIDC1_HUMAN "Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1)" TIMMDC1 C3orf1 UNQ247/PRO284 Homo sapiens (Human) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ALHELKLEEWKGR;DEQQRISK;FDAVQSAHRAATR 3 11.9 0.95509 -0.83265 0 0 0 10.9857 0 0 10.1154 0 0 0 0 11.4506 Q9NPP4 NLRC4_HUMAN "NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)" NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215 Homo sapiens (Human) activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein processing [GO:0010954]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269] canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; IPAF inflammasome complex [GO:0072557]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; caspase binding [GO:0089720]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] GNGYLQK;LTFLQEAR;RLSSLLTSHEPEEVTK;STFTEPVLWRK 4 4.1 0.98166 -1.583 11.0664 0 0 0 0 0 0 0 0 0 0 0 Q9NPQ8 RIC8A_HUMAN Chaperone Ric-8A (Synembryn-A) RIC8A Homo sapiens (Human) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; basement membrane organization [GO:0071711]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion involved in gastrulation [GO:0070586]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; vasculature development [GO:0001944]; visual learning [GO:0008542] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein folding chaperone [GO:0044183] AQGWPPPQVLPPLR;VIQPMGMSPR 2 4.5 0.55199 0.18325 0 0 0 0 0 0 6.91397 0 0 0 0 6.32504 Q9NPR2 SEM4B_HUMAN Semaphorin-4B (Semaphorin-C) SEMA4B KIAA1745 SEMAC UNQ749/PRO1480 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] GDEGGER;INSSLQLPDR 2 2 0.95261 -0.75324 0 0 0 0 0 5.06031 0 0 0 0 10.839 0 Q9NPR9 GP108_HUMAN Protein GPR108 (Lung seven transmembrane receptor 2) GPR108 LUSTR2 Homo sapiens (Human) negative regulation of toll-like receptor signaling pathway [GO:0034122]; regulation of immune response [GO:0050776] cis-Golgi network membrane [GO:0033106]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] DLQVQVR;VAVNLAKLKLFR;VDGGGTSAASKPK 3 5.9 0.95567 -0.94229 11.2772 4.69961 0 0 0 0 0 0 6.25058 0 0 0 Q9NPY3 C1QR1_HUMAN Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93) CD93 C1QR1 MXRA4 Homo sapiens (Human) angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; macrophage activation [GO:0042116]; phagocytosis [GO:0006909] cell surface [GO:0009986]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; signaling receptor activity [GO:0038023] LLLFYILGTVVAILLLLALALGLLVYRKR 1 4.4 0.71154 0.15682 0 0 6.4129 0 0 0 0 0 0 0 0 0 Q9NQ03 SCRT2_HUMAN Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein) SCRT2 FP7030 Homo sapiens (Human) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AGAQAGGGHRHACAECGK 1 5.9 0.92173 -0.44111 8.57928 0 0 0 0 0 0 0 0 0 0 0 Q9NQ11 AT132_HUMAN Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) ATP13A2 PARK9 Homo sapiens (Human) autophagosome organization [GO:1905037]; autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to zinc ion [GO:0071294]; extracellular exosome biogenesis [GO:0097734]; intracellular calcium ion homeostasis [GO:0006874]; intracellular iron ion homeostasis [GO:0006879]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; lipid homeostasis [GO:0055088]; lysosomal transport [GO:0007041]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of lysosomal protein catabolic process [GO:1905166]; peptidyl-aspartic acid autophosphorylation [GO:1990938]; polyamine transmembrane transport [GO:1902047]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein autophosphorylation [GO:0046777]; protein localization to lysosome [GO:0061462]; regulation of autophagosome size [GO:0016243]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of endopeptidase activity [GO:0052548]; regulation of intracellular protein transport [GO:0033157]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of protein localization to nucleus [GO:1900180]; regulation of ubiquitin-specific protease activity [GO:2000152]; spermine transmembrane transport [GO:1903710]; transmembrane transport [GO:0055085] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; vesicle [GO:0031982] "ABC-type polyamine transporter activity [GO:0015417]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; cupric ion binding [GO:1903135]; manganese ion binding [GO:0030145]; P-type ion transporter activity [GO:0015662]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; polyamine transmembrane transporter activity [GO:0015203]; zinc ion binding [GO:0008270]" ALATCHALSR;LRLRPCNLAHAETLVIEIRDK;RPLYTNERARPVPPR 3 4 0.9547 -0.95672 0 11.3254 0 10.0355 0 9.95126 0 0 0 0 0 0 Q9NQ25 SLAF7_HUMAN SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) SLAMF7 CS1 UNQ576/PRO1138 Homo sapiens (Human) adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] KLCEEYIEEK;VTMGLQSNK 2 10.1 0.87878 -0.14155 0 0 0 0 0 0 0 10.5798 0 0 4.19432 0 Q9NQ30 ESM1_HUMAN Endothelial cell-specific molecule 1 (ESM-1) ESM1 Homo sapiens (Human) angiogenesis [GO:0001525]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hepatocyte growth factor receptor signaling pathway [GO:1902204]; sprouting angiogenesis [GO:0002040] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201]; hepatocyte growth factor receptor binding [GO:0005171]; integrin binding [GO:0005178] DCPYGTFGMDCR 1 6.5 0.8098 0.0092515 0 0 0 0 0 0 0 2.7015 0 0 0 0 Q9NQ31 AKIP1_HUMAN A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3) AKIP1 BCA3 C11orf17 Homo sapiens (Human) regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; substrate adhesion-dependent cell spreading [GO:0034446] nucleoplasm [GO:0005654] KTHVVAVDSGQSVDLVFPV;QPAAGPQRVLPGEK 2 18 0.97539 -1.4567 0 0 0 0 0 0 0 9.98257 0 0 0 0 Q9NQ32 CK016_HUMAN Uncharacterized protein C11orf16 C11orf16 Homo sapiens (Human) DPQRASK 1 1.7 0.90205 -0.26114 0 0 6.79909 0 0 0 0 0 0 0 0 0 Q9NQ35 NRIP3_HUMAN Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105) NRIP3 C11orf14 Homo sapiens (Human) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] LMETNLSK;LSLPRHLK;LSLPRHLKVVGQIEHLVITLGSLR 3 13.3 0.97987 -1.8755 0 0 0 5.97124 0 0 0 0 0 0 0 0 Q9NQ36 SCUB2_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You)" SCUBE2 CEGP1 Homo sapiens (Human) signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; lipid binding [GO:0008289] EVTASCDLSCIVKRTEK;SCQDVDECSLDR 2 2.9 0.84862 -0.071276 0 0 7.23984 0 9.67495 0 0 0 0 0 0 0 Q9NQ38 ISK5_HUMAN Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] SPINK5 Homo sapiens (Human) cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; epidermal cell differentiation [GO:0009913]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antibacterial peptide production [GO:0002787]; negative regulation of immune response [GO:0050777]; negative regulation of proteolysis [GO:0045861]; regulation of cell adhesion [GO:0030155]; regulation of T cell differentiation [GO:0045580]; regulation of timing of anagen [GO:0051884] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase inhibitor activity [GO:0004867] EFRSMQRNGK;LEEEEKK;LFCPQDK;MHINKCAMCQSIFDR;SNTGERSNTGERSNDK;TGSQIGVK 6 5.9 0.97912 -1.882 15.3 0 0 0 10.415 5.80614 8.60485 0 5.46545 6.23787 0 0 Q9NQ39 RS10L_HUMAN Putative ribosomal protein eS10-like (Putative 40S ribosomal protein S10-like) RPS10P5 RPS10L Homo sapiens (Human) cytosolic small ribosomal subunit [GO:0022627] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AEAGAGSATEFQFR;IAIHELLFK 2 13.1 0.9088 -0.31614 12.1874 0 0 0 0 0 0 0 0 0 0 0 Q9NQ48 LZTL1_HUMAN Leucine zipper transcription factor-like protein 1 LZTFL1 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; negative regulation of protein localization to ciliary membrane [GO:1903568]; negative regulation of protein localization to cilium [GO:1903565]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; manchette [GO:0002177] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] SIKLYPTHPLVTFPR 1 5.9 0.88985 -0.20621 0 0 0 0 8.18636 0 0 0 0 0 0 0 Q9NQ50 RM40_HUMAN "Large ribosomal subunit protein mL40 (39S ribosomal protein L40, mitochondrial) (L40mt) (MRP-L40) (Nuclear localization signal-containing protein deleted in velocardiofacial syndrome) (Up-regulated in metastasis)" MRPL40 NLVCF URIM Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] RNA binding [GO:0003723] ATQELIPIEDFITPLK 1 7.8 0.89312 -0.21791 8.15213 0 0 0 0 0 0 0 10.668 0 0 0 Q9NQ55 SSF1_HUMAN Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) PPAN BXDC3 SSF1 Homo sapiens (Human) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" "nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723]; rRNA binding [GO:0019843] FPKTKDK;GNMRAQQSAVR;LAKSPGRK;SQGAQAR 4 7 0.97538 -4.2546 0 0 0 0 9.37012 0 0 11.8376 0 0 11.4473 10.5683 Q9NQ66 PLCB1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)" PLCB1 KIAA0581 Homo sapiens (Human) "activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; learning [GO:0007612]; ligand-gated ion channel signaling pathway [GO:1990806]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]; signal transduction [GO:0007165]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991] "calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase C activity [GO:0004629]" CVELDCWK;GLEQLTKSPVEFVEYNK;SSEGSGK 3 2.6 0.7127 0.14561 6.63904 9.93373 0 0 0 0 0 0 0 0 0 11.6433 Q9NQ69 LHX9_HUMAN LIM/homeobox protein Lhx9 (LIM homeobox protein 9) LHX9 Homo sapiens (Human) cell population proliferation [GO:0008283]; dorsal spinal cord interneuron anterior axon guidance [GO:0097380]; female gonad development [GO:0008585]; gonad morphogenesis [GO:0035262]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LALESELTCFAK;VLQVWFQNARAKFR;YYLLAVDKQWHLR 3 9.8 0.97323 -2.5139 0 0 0 0 0 0 0 12.5172 0 0 0 0 Q9NQ75 CASS4_HUMAN Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) CASS4 C20orf32 HEFL Homo sapiens (Human) cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] protein tyrosine kinase binding [GO:1990782] NCEKEETVQLTPNAEFKCEK 1 2.5 0.85174 -0.079704 0 0 0 0 0 0 0 8.7499 0 0 0 0 Q9NQ76 MEPE_HUMAN Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin) MEPE Homo sapiens (Human) biomineral tissue development [GO:0031214]; skeletal system development [GO:0001501] endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] extracellular matrix protein binding [GO:1990430]; extracellular matrix structural constituent [GO:0005201] GLDNEIK;RDDSSESSDSGSSSESDGD;VEFHYPPAPSKEK 3 7.4 0.95471 -0.80022 0 0 0 0 0 5.46917 0 0 0 8.7974 0 0 Q9NQ79 CRAC1_HUMAN Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC) CRTAC1 ASPIC1 CEP68 Homo sapiens (Human) axonal fasciculation [GO:0007413] extracellular exosome [GO:0070062] calcium ion binding [GO:0005509] MVSRNVASGEMNSVLEILYPR 1 3.2 0.92109 -0.43896 0 0 0 0 0 0 8.79974 0 0 0 0 0 Q9NQ86 TRI36_HUMAN E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) acrosome reaction [GO:0007340]; mitotic cytokinesis [GO:0000281]; regulation of cell cycle [GO:0051726]; regulation of microtubule cytoskeleton organization [GO:0070507]; spindle organization [GO:0007051] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] alpha-tubulin binding [GO:0043014]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AIDSSKKLR;HFWAFRVEPYSYLVKVGVASSDK;ILMCPEHETER;LGGNHANHR;SCMDCSASYCNECFK 5 9.2 0.98001 -1.8339 0 10.968 0 5.40552 0 0 0 0 0 5.01832 8.20256 0 Q9NQ87 HEYL_HUMAN Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3) HEYL BHLHB33 HRT3 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to BMP stimulus [GO:0071773]; circulatory system development [GO:0072359]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; glomerulus development [GO:0032835]; mesenchymal cell development [GO:0014031]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "AF-1 domain binding [GO:0050683]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEVLQMTVDHLKMLHATGGTGFFDAR;RNVLPSR 2 10.1 0.93598 -0.53674 0 0 0 0 9.45302 0 0 0 0 0 0 7.17203 Q9NQ88 TIGAR_HUMAN "Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)" TIGAR C12orf5 Homo sapiens (Human) "cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; glucose catabolic process to lactate via pyruvate [GO:0019661]; glycolytic process [GO:0006096]; intestinal epithelial cell development [GO:0060576]; mitophagy [GO:0000423]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of glycolytic process [GO:0045820]; negative regulation of mitophagy [GO:1901525]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA repair [GO:0045739]; positive regulation of hexokinase activity [GO:1903301]; positive regulation of pentose-phosphate shunt [GO:1905857]; reactive oxygen species metabolic process [GO:0072593]; regulation of pentose-phosphate shunt [GO:0043456]; regulation of response to DNA damage checkpoint signaling [GO:1902153]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] "fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" ALSELRAMAK;SLFDYFLTDLK 2 7.8 0.96805 -1.3254 0 0 0 0 0 0 0 5.53534 0 0 0 0 Q9NQ89 FERY3_HUMAN Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) FERRY3 C12orf4 Homo sapiens (Human) regulation of mast cell degranulation [GO:0043304] cytoplasm [GO:0005737]; early endosome [GO:0005769]; protein-containing complex [GO:0032991] IYEEQRK;QGIEMEKVMQELGK;QSTAIQK 3 5.1 0.98011 -1.866 0 0 0 0 0 0 0 0 0 0 0 4.71562 Q9NQ90 ANO2_HUMAN Anoctamin-2 (Transmembrane protein 16B) ANO2 C12orf3 TMEM16B Homo sapiens (Human) chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] chloride channel complex [GO:0034707]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] EMCDQQNAFTMCPLCDK;LLYQEWAR;SPGGGDR 3 3.2 0.64169 0.17179 10.9838 11.9056 5.80578 0 0 9.8724 0 0 0 9.37365 0 11.404 Q9NQ94 A1CF_HUMAN APOBEC1 complementation factor (APOBEC1-stimulating protein) A1CF ACF ASP Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; cytidine to uridine editing [GO:0016554]; embryo implantation [GO:0007566]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; protein stabilization [GO:0050821]" apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme-substrate adaptor activity [GO:0140767]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] GCEIFIGK;LSAFVDEAK;MMMDFNGNNR;VTEGVVDVIVYPSAADK 4 7.4 0.95531 -0.93662 0 0 0 0 0 7.93911 0 0 0 11.2741 5.59276 11.3413 Q9NQ94 A1CF_HUMAN APOBEC1 complementation factor (APOBEC1-stimulating protein) A1CF ACF ASP Homo sapiens (Human) "chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; cytidine to uridine editing [GO:0016554]; embryo implantation [GO:0007566]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; protein stabilization [GO:0050821]" apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme-substrate adaptor activity [GO:0140767]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] LSAFVDEAK;MMMDFNGNNR;MRMMMDFNGNNR;VTEGVVDVIVYPSAADK 4 7.5 0.92358 -0.44822 0 0 0 0 0 0 0 0 0 10.6165 12.1147 8.57088 Q9NQA3 WASH6_HUMAN WAS protein family homolog 6 (Protein FAM39A) WASH6P CXYorf1 FAM39A Homo sapiens (Human) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] QVEQSRSQVQAIGEKVSLAQAK 1 4.9 0.95398 -0.91561 0 9.31807 0 0 0 0 0 0 0 0 0 0 Q9NQA5 TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) TRPV5 ECAC1 Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809] apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] EARQILEQTPVK;ELVSFKWNK;MGGFLPK;THSRDITILQQKLLQEAYETR 4 6.7 0.97993 -1.8313 0 0 0 6.16253 0 0 9.12725 0 9.07286 0 0 0 Q9NQB0 TF7L2_HUMAN Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) TCF7L2 TCF4 Homo sapiens (Human) blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; maintenance of DNA repeat elements [GO:0043570]; myoblast fate commitment [GO:0048625]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; pancreas development [GO:0031016]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone metabolic process [GO:0032350]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749] beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; catenin-TCF7L2 complex [GO:0071664]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993] "armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; gamma-catenin binding [GO:0045295]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" QTLWCKPCR;VVAECTLK 2 2.7 0.9634 -1.0982 0 0 0 0 0 0 0 10.3577 0 0 0 0 Q9NQC1 JADE2_HUMAN E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) JADE2 KIAA0239 PHF15 Homo sapiens (Human) protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular exosome [GO:0070062]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654] histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872] DPSLRPGDPAR;SPEGEDGNEMVFCDK 2 3.3 0.91672 -0.36364 0 0 0 5.374 0 0 0 0 0 0 0 10.4797 Q9NQC3 RTN4_HUMAN Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; blastocyst formation [GO:0001825]; brain development [GO:0007420]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell adhesion involved in sprouting angiogenesis [GO:0120078]; cell migration involved in vasculogenesis [GO:0035441]; cellular response to hypoxia [GO:0071456]; central nervous system vasculogenesis [GO:0022009]; cerebral cortex radial glia-guided migration [GO:0021801]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; endoplasmic reticulum tubular network organization [GO:0071786]; intracellular sphingolipid homeostasis [GO:0090156]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of vasculogenesis [GO:2001213]; neuron differentiation [GO:0030182]; nuclear pore complex assembly [GO:0051292]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERBB3 signaling pathway [GO:1905580]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration [GO:1905523]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334]; regulation of postsynapse assembly [GO:0150052] anchoring junction [GO:0070161]; cell junction [GO:0030054]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] GPLPAAPPVAPER;GVIQAIQK;IESNLESK;NIQPKVEEK;QPSWDPSPVSSTVPAPSPLSAAAVSPSK 5 5.5 0.0085837 1.0101 11.8654 0 0 9.5795 8.49345 8.72595 11.2396 11.4593 14.6083 11.9361 11.7535 8.71809 Q9NQC7 CYLD_HUMAN Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) CYLD CYLD1 KIAA0849 HSPC057 Homo sapiens (Human) "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; homeostasis of number of cells [GO:0048872]; innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein localization [GO:1903829]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; proteolysis [GO:0006508]; regulation of B cell differentiation [GO:0045577]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; ripoptosome assembly involved in necroptotic process [GO:1901026]; Wnt signaling pathway [GO:0016055]" centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; Met1-linked polyubiquitin deubiquitinase activity [GO:0061815]; proline-rich region binding [GO:0070064]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] GLQIDVGCPVKVQLR 1 1.6 0.95212 -0.70762 0 0 0 0 0 0 0 0 0 8.67994 0 0 Q9NQC8 IFT46_HUMAN Intraflagellar transport protein 46 homolog IFT46 C11orf2 C11orf60 Homo sapiens (Human) cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; protein stabilization [GO:0050821] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514] ADNSSDECEEENNK;MADNSSDECEEENNK 2 4.9 0.89174 -0.2144 0 0 0 0 0 0 0 0 6.33425 0 0 6.57287 Q9NQG1 MANBL_HUMAN Protein MANBAL MANBAL Homo sapiens (Human) membrane [GO:0016020] SAEVTRKPKAAVPSVNK 1 20 0.86061 -0.082651 0 0 0 0 0 0 10.8295 0 0 0 0 0 Q9NQG6 MID51_HUMAN Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) MIEF1 MID51 SMCR7L Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of protein targeting to membrane [GO:0090314] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; GDP binding [GO:0019003]; identical protein binding [GO:0042802] AGSGQASCCGHMCR 1 9.5 0.80041 0.014571 0 0 0 0 0 0 0 6.06147 3.33299 5.61815 3.19155 0 Q9NQG7 HPS4_HUMAN BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) HPS4 KIAA1667 Homo sapiens (Human) blood coagulation [GO:0007596]; hemostasis [GO:0007599]; intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; platelet dense granule [GO:0042827] guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] TAPQEQR;VDGDYLWVLGCAVELPDVSCKR 2 4.1 0.84706 -0.067844 0 0 0 0 0 0 7.29637 0 0 7.96139 0 0 Q9NQH7 XPP3_HUMAN Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) XPNPEP3 Homo sapiens (Human) glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803] MLCSQRR;SPAEIER;VRGVQQLIQRLR 3 5.4 0.96529 -1.256 0 0 10.6051 8.46238 0 0 0 0 0 0 0 0 Q9NQI0 DDX4_HUMAN Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) DDX4 VASA Homo sapiens (Human) cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; gamete generation [GO:0007276]; germ cell development [GO:0007281]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; pi-body [GO:0071546]; piP-body [GO:0071547] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] DLMACAQTGSGK;SEAEGGESSDTQGPK;YLVLDEADR 3 5 0.7833 0.02868 0 0 0 0 0 0 4.12697 0 0 0 0 0 Q9NQL2 RRAGD_HUMAN Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) RRAGD Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; membrane scission GTPase motor activity [GO:1990606]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982] AIHEVFEVR;GLIDYNFHCFR;IETQRDIHQR;ILLMGLR;VQNRLQKK 5 11.2 0.64665 0.17138 0 0 0 0 0 0 0 0 0 8.99461 0 0 Q9NQL2 RRAGD_HUMAN Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) RRAGD Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization [GO:0008104] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; membrane scission GTPase motor activity [GO:1990606]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982] AIHEVFEVR;EALARLHLTVTR;GLIDYNFHCFR;IETQRDIHQR;VQNRLQKK 5 20.1 0.98077 -1.6206 10.8718 0 11.3614 4.15486 7.10967 0 0 11.6226 11.6676 0 0 0 Q9NQL9 DMRT3_HUMAN Doublesex- and mab-3-related transcription factor 3 DMRT3 DMRTA3 Homo sapiens (Human) adult walking behavior [GO:0007628]; male sex differentiation [GO:0046661]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; transmission of nerve impulse [GO:0019226]; ventral spinal cord interneuron specification [GO:0021521] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SDSSDSR 1 1.5 0.9154 -0.33244 0 0 0 0 0 0 7.33271 0 0 0 0 0 Q9NQN1 OR2S1_HUMAN Olfactory receptor 2S2 (Olfactory receptor OR9-3) OR2S2 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSAHPELEK 1 2.8 0.90954 -0.31484 0 0 0 0 0 0 0 0 0 0 0 10.7825 Q9NQP4 PFD4_HUMAN Prefoldin subunit 4 (Protein C-1) PFDN4 PFD4 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] AAAEDVNVTFEDQQK;NLQEEIDALESR 2 20.1 0.88961 -0.20577 0 8.90307 7.98743 5.78756 9.22665 5.53035 0 0 0 7.70037 0 0 Q9NQR4 NIT2_HUMAN Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) NIT2 CUA002 Homo sapiens (Human) asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] 2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152] SDLYAVEMKKP 1 4 0.92118 -0.43993 0 0 0 0 0 0 0 0 0 5.99485 0 0 Q9NQR7 CC177_HUMAN Coiled-coil domain-containing protein 177 (Myelin proteolipid protein-like protein) CCDC177 C14orf162 PLPL Homo sapiens (Human) AERERIMR;GLRGVPER;IMREEKR;LQQEQNLKQR;SLEACARCAVKPVELLPR 5 6.8 0.98107 -2.0305 0 11.4686 11.0567 0 0 0 0 11.1521 10.4386 0 8.14267 0 Q9NQR9 G6PC2_HUMAN Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) G6PC2 IGRP Homo sapiens (Human) gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; regulation of insulin secretion [GO:0050796] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucose-6-phosphatase activity [GO:0004346] VLNIDLLWSVPIAK 1 3.9 0.64112 0.17261 0 0 0 8.99317 0 0 0 0 0 0 0 0 Q9NQS1 AVEN_HUMAN Cell death regulator Aven AVEN Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] GGGGAPR 1 1.9 0.69853 0.16173 0 0 0 0 0 9.42057 0 0 0 0 0 0 Q9NQS3 NECT3_HUMAN Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) NECTIN3 PRR3 PVRL3 Homo sapiens (Human) cochlea morphogenesis [GO:0090103]; establishment of protein localization to plasma membrane [GO:0061951]; fertilization [GO:0009566]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of postsynapse assembly [GO:0150052]; retina morphogenesis in camera-type eye [GO:0060042]; symbiont entry into host cell [GO:0046718] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] RTPGLLRGPLLPR 1 2.7 0.87109 -0.09544 5.90634 0 0 0 0 0 0 0 0 0 0 0 Q9NQS7 INCE_HUMAN Inner centromere protein INCENP Homo sapiens (Human) chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970] "central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]" molecular function activator activity [GO:0140677] EEAEQLRRQK;EEQQRLAER;IICHSYLER;LAEQREQER;QLQEEQEK;TPSSPCPASK 6 6 0.97539 -3.4108 0 0 8.31293 3.6912 0 0 0 10.3615 0 10.6971 11.7213 0 Q9NQT4 EXOS5_HUMAN Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) EXOSC5 CML28 RRP46 Homo sapiens (Human) defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; mRNA catabolic process [GO:0006402]; nuclear mRNA surveillance [GO:0071028]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475] cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; DNA binding [GO:0003677]; RNA binding [GO:0003723] ATLEVILRPK 1 4.3 0.89636 -0.24807 0 5.63087 0 0 0 0 0 0 0 0 0 0 Q9NQT5 EXOS3_HUMAN Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10) EXOSC3 RRP40 CGI-102 Homo sapiens (Human) "CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; mRNA catabolic process [GO:0006402]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; RNA binding [GO:0003723] AEPASVAAESLAGSR 1 9.1 0 3.7729 0 0 0 0 0 0 0 0 0 0 9.47715 0 Q9NQT6 FSCN3_HUMAN Fascin-3 (Testis fascin) FSCN3 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163] actin cytoskeleton [GO:0015629]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; ruffle [GO:0001726] actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674] TGRFISVIYDGEVR 1 2.8 0.94445 -0.63992 0 0 0 0 0 0 0 0 0 0 10.0132 0 Q9NQT8 KI13B_HUMAN Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) KIF13B GAKIN KIAA0639 Homo sapiens (Human) microtubule-based movement [GO:0007018]; protein targeting [GO:0006605]; regulation of axonogenesis [GO:0050770]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vesicle transport along microtubule [GO:0047496] axon [GO:0030424]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901] DLREEVEK;DRLEESEKLIQEMTVTWEEK;EAQLLEMRLTLTEER;IIRDLREEVEK;KTEEIAQER;LGAPEAR;LMYEHELEQLRR;LSLVDLAGSER;SALERQR;THETFHEEEEDMDSYQDRDLERLR;VEVSYMEIYNEKVR;VTLQIPASSLDANR 12 7.9 0.97748 -5.8559 0 12.278 0 8.32238 6.75515 8.46324 0 12.1029 0 0 10.3822 11.1817 Q9NQU5 PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) PAK6 PAK5 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; neuron projection arborization [GO:0140058]; neuron projection extension [GO:1990138]; regulation of DNA-templated transcription [GO:0006355]; regulation of MAPK cascade [GO:0043408] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IGEGSTGIVCLAR;LSVISSNTLRGR;VSPVLRDFLER 3 5.3 0.97861 -2.0757 12.351 0 0 0 0 0 0 0 0 0 8.54581 11.8625 Q9NQV5 PRD11_HUMAN PR domain-containing protein 11 (EC 2.1.1.-) PRDM11 PFM8 Homo sapiens (Human) methylation [GO:0032259]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408] cytosol [GO:0005829]; nucleus [GO:0005634] chromatin binding [GO:0003682]; methyltransferase activity [GO:0008168] SIDGSDETK;YVVISREER 2 3.5 0.93638 -0.53378 0 0 7.22294 0 0 0 0 0 0 0 0 0 Q9NQV6 PRD10_HUMAN PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) PRDM10 KIAA1231 PFM7 TRIS Homo sapiens (Human) methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] IPKRTQFGPVEGPLVR;SVTELNGDIITNTMTLGDIVFKRISK;VSLDKGDR 3 4.1 0.97448 -1.4286 0 0 0 8.28096 0 0 0 0 0 0 0 0 Q9NQV7 PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361) PRDM9 PFM6 Homo sapiens (Human) double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; methylation [GO:0032259]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; protein homodimerization activity [GO:0042803]; recombination hotspot binding [GO:0010844]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] AFSSPPK;ASFSNESSLK;EEWAEMGDWEK;FLSQHVER;LQVDDTEDSDEEWTPR 5 5.8 0.95531 -0.8658 0 0 9.15568 0 4.81834 10.456 0 3.52381 0 0 8.31719 0 Q9NQV8 PRDM8_HUMAN PR domain zinc finger protein 8 (EC 2.1.1.-) (PR domain-containing protein 8) PRDM8 PFM5 Homo sapiens (Human) corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; methylation [GO:0032259]; oligodendrocyte development [GO:0014003]; regulation of DNA-templated transcription [GO:0006355] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] DQQQQQQEAPLGPGPKFCK 1 2.8 0.91539 -0.39163 0 0 0 0 0 0 0 4.80483 0 0 0 0 Q9NQW1 SC31B_HUMAN Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B) (SEC31B-1) SEC31B SEC31L2 Homo sapiens (Human) COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031] COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; vesicle coat [GO:0030120] structural molecule activity [GO:0005198] ISSLLACVVQKNWK;KELPPEHQSLK;LEYLYEK;VLESHSR 4 3.3 0.98064 -1.5531 0 0 0 0 0 14.274 11.8492 0 10.0014 0 10.3388 0 Q9NQW5 PRDM7_HUMAN Histone-lysine N-methyltransferase PRDM7 (EC 2.1.1.-) (PR domain zinc finger protein 7) (PR domain-containing protein 7) ([histone H3]-lysine4 N-methyltransferase PRDM7) PRDM7 PFM4 Homo sapiens (Human) methylation [GO:0032259]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; recombination hotspot binding [GO:0010844] AFSSPPK;FLSQHVER;GQMGSSR;VGERMMEEESRTGQK 4 9.1 0.86899 -0.09135 0 8.55972 0 0 0 8.95332 0 0 0 0 0 7.87768 Q9NQW5 PRDM7_HUMAN Histone-lysine N-methyltransferase PRDM7 (EC 2.1.1.-) (PR domain zinc finger protein 7) (PR domain-containing protein 7) ([histone H3]-lysine4 N-methyltransferase PRDM7) PRDM7 PFM4 Homo sapiens (Human) methylation [GO:0032259]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; recombination hotspot binding [GO:0010844] TSPTRESLPR 1 5.8 0.88814 -0.18341 0 0 0 0 0 7.93109 0 0 0 0 0 0 Q9NQW6 ANLN_HUMAN Anillin ANLN Homo sapiens (Human) actomyosin contractile ring assembly [GO:0000915]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic cytokinesis [GO:0000281]; podocyte cell migration [GO:0090521]; positive regulation of bleb assembly [GO:1904172]; regulation of exit from mitosis [GO:0007096]; septin ring assembly [GO:0000921]; septin ring organization [GO:0031106] actin cytoskeleton [GO:0015629]; actomyosin contractile ring [GO:0005826]; bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; cadherin binding [GO:0045296] DLLYSIDAYR;DLLYSIDAYRSQRFK;FDKGNIWSAEK;LKNEGPQR;MAERPTAAPRSMTHAKR;QIEPANREFCARR 6 5.7 0.97496 -4.1255 0 0 0 0 0 0 0 12.7195 0 7.51515 7.67948 10.4041 Q9NQW7 XPP1_HUMAN "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803] DAVALCELFNWLEKEVPK;GSLTFEPLTLVPIQTK;KMAKVLR;QGRQEALEWLIR 4 8.5 0.97484 -2.3985 9.64776 0 6.80645 0 11.1905 11.0045 8.71146 7.96815 0 11.3024 11.1777 0 Q9NQX0 PRDM6_HUMAN Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6) PRDM6 PFM3 Homo sapiens (Human) methylation [GO:0032259]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] histone H4K20 monomethyltransferase activity [GO:0140944]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] EIIPLNQHTSDPNNR;VQAGAVR 2 5.3 0.87368 -0.11058 0 0 10.1292 0 0 0 0 0 0 11.978 8.88469 0 Q9NQX1 PRDM5_HUMAN PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5) PRDM5 PFM2 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of extracellular matrix organization [GO:1903053] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" CHHCDATFK;KKLICSVCNK;THTREKPYK 3 4.4 0.56699 0.18224 0 0 9.64156 0 0 3.82283 0 0 0 0 0 0 Q9NQX3 GEPH_HUMAN Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] GPHN GPH KIAA1385 Homo sapiens (Human) establishment of synaptic specificity at neuromuscular junction [GO:0007529]; gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; response to metal ion [GO:0010038] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; postsynaptic specialization membrane [GO:0099634]; synaptic membrane [GO:0097060] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin cofactor binding [GO:0043546]; molybdopterin molybdotransferase activity [GO:0061599]; nitrate reductase activity [GO:0008940]; protein-macromolecule adaptor activity [GO:0030674] LSTASCPTPK 1 1.4 0.88749 -0.19052 13.0926 0 0 0 0 0 0 0 0 0 0 0 Q9NQX4 MYO5C_HUMAN Unconventional myosin-Vc MYO5C Homo sapiens (Human) actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] EIELLQAQKIDVEKHVQSQK;EKEKLIDK;LEQEEYMK;QFETESEVKCNFRQEASR;SGSNAHVEDK;TISEFEK;VLASNPITEAVGNAK;YADSLNDANMLK 8 5.6 0.93651 -0.55875 12.5866 0 0 9.94166 0 8.65105 9.67869 11.3778 5.1334 9.31744 0 12.0238 Q9NQX6 ZN331_HUMAN Zinc finger protein 331 (C2H2-like zinc finger protein rearranged in thyroid adenomas) (Zinc finger protein 361) (Zinc finger protein 463) ZNF331 RITA ZNF361 ZNF463 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" FHTGEKDYECKDCGK;GYQLSQHQKIHTGEKPYECK;IHTGETPYK;WGNQLTQHQK 4 11.7 0.97503 -1.443 0 0 9.65354 0 0 7.28734 0 0 0 9.52091 0 10.0716 Q9NQY0 BIN3_HUMAN Bridging integrator 3 BIN3 Homo sapiens (Human) actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; cytoskeleton-dependent cytokinesis [GO:0061640]; endocytosis [GO:0006897]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; plasma membrane tubulation [GO:0097320]; protein localization [GO:0008104]; regulation of lamellipodium assembly [GO:0010591]; skeletal muscle fiber development [GO:0048741]; unidimensional cell growth [GO:0009826] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] cytoskeletal anchor activity [GO:0008093] DMKKSTDADLAMSK;LQQLEEQTRRLQK;TVERDFER 3 13.8 0.97461 -3.1222 0 9.58693 0 0 0 0 0 10.0366 0 0 0 0 Q9NQZ2 SAS10_HUMAN Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) UTP3 CRLZ1 SAS10 Homo sapiens (Human) "brain development [GO:0007420]; chromatin organization [GO:0006325]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] AITYQIAKNR;IDRNPRVK;KLYYDTDYGSK;LVTYRNLINKLSVVDQK;NLINKLSVVDQKLSSEIR;YSGELSGIR;YYKEIEDR 7 14.4 0.97426 -3.051 0 0 9.91988 0 8.9025 0 0 0 0 5.06117 9.97456 0 Q9NQZ7 ENTP7_HUMAN Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.15) (Lysosomal apyrase-like protein 1) ENTPD7 LALP1 Homo sapiens (Human) CTP catabolic process [GO:0006254]; CTP metabolic process [GO:0046036]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; regulation of immune response [GO:0050776]; T-helper 17 cell differentiation [GO:0072539]; UDP catabolic process [GO:0006256]; UTP catabolic process [GO:0046052] cytoplasmic vesicle membrane [GO:0030659]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] ISFSYLCPASWYFTVPTVSPFLR 1 3.8 0.93074 -0.47705 0 0 0 0 0 0 0 0 0 0 12.9781 0 Q9NR00 TCIM_HUMAN Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1) TCIM C8orf4 TC1 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; endothelial cell activation involved in immune response [GO:0002264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of hemopoiesis [GO:1903706] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] Notch binding [GO:0005112] LFRNSGDK;TRALMALKK 2 16 0.98091 -1.6069 0 0 0 0 0 0 0 10.643 0 0 0 0 Q9NR09 BIRC6_HUMAN Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; labyrinthine layer development [GO:0060711]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; Flemming body [GO:0090543]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802] cysteine-type endopeptidase inhibitor activity [GO:0004869]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] AEVASAVCLR;FSATVPPCWVEVQQEQQQR;FVLNSNITNIPQIQVTLLKNKAPGLGK;ICIWDVSKLMKVHLK;IGLKLIDILLR;IGLQSTRIGLKLIDILLR;KNHEEKEK;VCFFEAGRSIAHK;VTMFLQSPCPLYK 9 2.5 0.97592 -2.3088 0 0 9.39421 0 10.9784 0 0 9.1813 0 0 8.94096 9.56091 Q9NR11 ZN302_HUMAN Zinc finger protein 302 (Zinc finger protein 135-like) (Zinc finger protein 140-like) (Zinc finger protein 327) ZNF302 ZNF135L ZNF140L ZNF327 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPWMMEKKLSK;KLSKDWESR;SVIKSERINGGK 3 7 0.97241 -2.7465 0 0 0 0 0 0 0 0 0 13.6001 0 2.58604 Q9NR12 PDLI7_HUMAN PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) PDLIM7 ENIGMA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle structure development [GO:0061061]; ossification [GO:0001503]; receptor-mediated endocytosis [GO:0006898] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371] CHGCDFK;VLEEGGFFEEK 2 3.9 0.95194 -0.68141 0 6.98607 0 0 0 0 0 0 0 0 0 0 Q9NR12 PDLI7_HUMAN PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) PDLIM7 ENIGMA Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle structure development [GO:0061061]; ossification [GO:0001503]; receptor-mediated endocytosis [GO:0006898] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371] QDSRVSPVPQGHPGPLPGGAGPR 1 8 0.83343 -0.029624 0 0 11.1792 0 0 0 0 0 0 0 0 0 Q9NR16 C163B_HUMAN Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b) CD163L1 CD163B M160 UNQ6434/PRO23202 Homo sapiens (Human) external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576] LEVYFQGR;QLGCGKPLHVFGMTYFK 2 1.7 0.94492 -0.6245 0 9.98413 0 0 0 0 0 0 0 0 0 0 Q9NR20 DYRK4_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) DYRK4 Homo sapiens (Human) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] DEITKETTEK;MTPDQALK 2 3.5 0.95631 -0.8513 0 0 0 0 0 0 9.97871 0 0 0 0 0 Q9NR21 PAR11_HUMAN Protein mono-ADP-ribosyltransferase PARP11 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) (Poly [ADP-ribose] polymerase 11) (PARP-11) PARP11 C12orf6 Homo sapiens (Human) cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein auto-ADP-ribosylation [GO:0070213]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; nucleotidyltransferase activity [GO:0016779] DAAYSSR;DAAYSSRFCK 2 3 0.9526 -0.76486 8.61493 0 0 0 8.42009 0 0 0 0 0 7.82324 0 Q9NR23 GDF3_HUMAN Growth/differentiation factor 3 (GDF-3) GDF3 UNQ222/PRO248 Homo sapiens (Human) endoderm development [GO:0007492]; eye development [GO:0001654]; formation of anatomical boundary [GO:0048859]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of myoblast differentiation [GO:0045662]; notochord development [GO:0030903]; positive regulation of fat cell differentiation [GO:0045600]; primitive streak formation [GO:0090009]; regulation of cell fate commitment [GO:0010453]; response to dietary excess [GO:0002021]; skeletal system development [GO:0001501]; somite rostral/caudal axis specification [GO:0032525] cytoplasm [GO:0005737]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein kinase binding [GO:0019901] LSCKNLCHR 1 2.5 0.93712 -0.52653 0 0 0 0 5.9211 0 0 0 0 0 0 0 Q9NR28 DBLOH_HUMAN "Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]" DIABLO SMAC Homo sapiens (Human) apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] LAEAQIEELR;SWLSRSVTSFFR 2 9.2 0.95514 -0.97299 0 0 0 0 0 0 0 0 0 0 6.93156 0 Q9NR30 DDX21_HUMAN Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) DDX21 Homo sapiens (Human) chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase I [GO:0016479]; osteoblast differentiation [GO:0001649]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; R-loop processing [GO:0062176]; response to exogenous dsRNA [GO:0043330]; rRNA processing [GO:0006364]; transcription by RNA polymerase II [GO:0006366] B-WICH complex [GO:0110016]; chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase inhibitor activity [GO:0140870]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515] AAVIGDVIR;APQVLVLAPTR;DFSDITK;EAQELSQNSAIK;EGAFSNFPISEETIK;EGYGGFR;ELANQVSK;GVTFLFPIQAK;IGVPSATEIIK;KEEPSQNDISPK;NGIDILVGTPGR;SFSKAFGQ;TAITVEHLAIK;TFSFAIPLIEK 14 18.5 0 4.9248 13.6754 13.9226 14.7363 10.7467 11.521 10.9498 0 11.217 8.18031 10.665 10.3467 10.9713 Q9NR34 MA1C1_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)" MAN1C1 MAN1A3 MAN1C Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" AIRLGEKLLPAFNTPTGIPK 1 3.2 0.85175 -0.079704 6.04306 0 0 0 0 0 4.94991 0 0 0 0 0 Q9NR46 SHLB2_HUMAN Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) SH3GLB2 KIAA1848 PP578 Homo sapiens (Human) membrane organization [GO:0061024] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; identical protein binding [GO:0042802] AVQFTEEK;KLASDAGIFFTR;VEEFLYEK 3 7.1 0.95516 -0.86363 0 0 0 0 0 0 0 0 9.5144 0 0 12.0275 Q9NR48 ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) ASH1L KIAA1420 KMT2H Homo sapiens (Human) decidualization [GO:0046697]; flagellated sperm motility [GO:0030317]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; methylation [GO:0032259]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; tarsal gland development [GO:1903699]; transcription by RNA polymerase II [GO:0006366]; uterine gland development [GO:1903709]; uterus morphogenesis [GO:0061038] bicellular tight junction [GO:0005923]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872] KGCVDDCLNR;LIQLKKEK;NIGPPSFVDHDFLK;NLDHVNK;QALAAPLLNLPPKKK;QMRSPVKMKPPVLSVAPFVATESPSK;VNGLTSSK 7 3 0.95484 -0.97259 0 0 0 8.99506 10.865 9.62192 8.60218 0 0 8.12309 0 6.63433 Q9NR50 EI2BG_HUMAN Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) EIF2B3 Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] AVEQRDFIGVDSTGK 1 3.3 0.91577 -0.43175 0 0 0 9.87364 0 0 0 0 0 0 0 0 Q9NR56 MBNL1_HUMAN Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) MBNL1 EXP KIAA0428 MBNL Homo sapiens (Human) embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] AVSVTPIR;EYQRGNCNR;NNLIQQK;RPLEATFDLGIPQAVLPPLPKRPALEK 4 13.1 0.96465 -1.1694 0 0 0 15.8276 0 13.8836 0 7.79889 0 7.44444 0 11.8863 Q9NR61 DLL4_HUMAN Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) DLL4 UNQ1895/PRO4341 Homo sapiens (Human) angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; signal transduction [GO:0007165]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222]; visual perception [GO:0007601] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018] GVLASGRPCEPGCRTFFR 1 2.6 0.91991 -0.43788 9.67147 0 0 0 0 0 0 0 0 0 0 0 Q9NR63 CP26B_HUMAN Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome) CYP26B1 CYP26A2 P450RAI2 Homo sapiens (Human) bone morphogenesis [GO:0060349]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; central nervous system development [GO:0007417]; cornification [GO:0070268]; embryonic limb morphogenesis [GO:0030326]; establishment of skin barrier [GO:0061436]; establishment of T cell polarity [GO:0001768]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; male meiotic nuclear division [GO:0007140]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of gene expression [GO:0010628]; positive regulation of tongue muscle cell differentiation [GO:2001037]; proximal/distal pattern formation [GO:0009954]; regulation of T cell differentiation [GO:0045580]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; spermatogenesis [GO:0007283]; tongue morphogenesis [GO:0043587]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789] "all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" EKYGNVFKTHLLGRPLIR;VLAVELASTSR 2 5.7 0.98106 -1.7447 0 0 0 0 7.57894 0 0 0 0 0 0 0 Q9NR64 KLHL1_HUMAN Kelch-like protein 1 KLHL1 KIAA1490 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; adult walking behavior [GO:0007628]; cerebellar Purkinje cell layer development [GO:0021680]; dendrite development [GO:0016358]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuronal cell body [GO:0043025] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] TLMQSPR 1 0.9 0.93301 -0.50133 0 12.2994 12.264 0 0 0 0 0 0 0 0 0 Q9NR71 ASAH2_HUMAN Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form] ASAH2 HNAC1 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to cytokine stimulus [GO:0071345]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; ceramide metabolic process [GO:0006672]; lipid digestion [GO:0044241]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of apoptotic signaling pathway [GO:2001234]; regulation of mitotic cell cycle [GO:0007346]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670] caveola [GO:0005901]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; N-acylsphingosine amidohydrolase activity [GO:0017040]; zinc ion binding [GO:0008270] SPYSYLQNPQSER 1 1.7 0.89824 -0.23325 0 0 0 0 0 0 0 0 0 8.31293 0 0 Q9NR80 ARHG4_HUMAN Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) ARHGEF4 KIAA1112 Homo sapiens (Human) filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904] VADGEGWFPASFVR 1 2 0.78541 0.018226 0 0 0 0 0 0 0 0 11.0666 0 0 0 Q9NR81 ARHG3_HUMAN Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN) ARHGEF3 Homo sapiens (Human) positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] ALLDHKK;MDSSTAMNQCSCRGMEENK;VKPLSRVTSLANLIPPVKATPLK 3 8.8 0.89327 -0.21936 0 16.1558 0 10.396 9.8445 11.4983 0 0 0 15.6312 0 0 Q9NR82 KCNQ5_HUMAN Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) KCNQ5 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805] clathrin coat [GO:0030118]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] QSQKLSFK;VDQILGK;VLLNSAAAR;VQEQHRQKHFEK 4 3.8 0.9809 -1.7599 10.0482 0 0 10.3086 0 0 0 0 0 8.99469 0 0 Q9NR96 TLR9_HUMAN Toll-like receptor 9 (CD antigen CD289) TLR9 UNQ5798/PRO19605 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cellular response to chloroquine [GO:1902350]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to metal ion [GO:0071248]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intestinal epithelial cell development [GO:1905300]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell differentiation [GO:0045577]; regulation of dendritic cell cytokine production [GO:0002730]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endolysosome [GO:0036019]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886] interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322] AFQGLTQLRKLNLSFNYQK;ALTNGSLPAGTR;ALTNGSLPAGTRLR;CDHAPNPCMECPR;CITKTKAFQGLTQLR;DEDALPYDAFVVFDK;LNLSFNYQKR;NLPKSLQVLR;VLDLSENFLYK 9 8.6 0.96474 -1.222 0 0 7.07328 0 0 4.74147 9.60446 6.03027 9.11824 10.7868 4.21054 0 Q9NR97 TLR8_HUMAN Toll-like receptor 8 (CD antigen CD288) TLR8 UNQ249/PRO286 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; response to virus [GO:0009615]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224] endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727] TAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLR 1 3.5 0.4 0.20949 0 6.52865 0 0 0 0 0 0 9.1469 0 0 0 Q9NR99 MXRA5_HUMAN Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) MXRA5 Homo sapiens (Human) response to transforming growth factor beta [GO:0071559] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201] EEGDYTCFAENQVGKDEMR;INGNPNPITTVR;ISQASRDSK;LNCMAMGIPK;SMEPSDSGLYQCIAQVR;VITGQTLQGLSNLMR;VSTGALMTPNTR;VTWLSPTNK;WFLEWDAKSRGILK 9 4.1 0.97462 -2.3905 6.08736 0 0 0 6.55113 5.3897 7.86567 0 0 11.8379 6.92636 7.66952 Q9NRA0 SPHK2_HUMAN Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) SPHK2 SK2 Homo sapiens (Human) blood vessel development [GO:0001568]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; female pregnancy [GO:0007565]; intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation involved in immune response [GO:0033008]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ATP biosynthetic process [GO:2001169]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]; transcription initiation-coupled chromatin remodeling [GO:0045815] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] ATP binding [GO:0005524]; D-erythro-sphingosine kinase activity [GO:0017050]; histone binding [GO:0042393]; lipid kinase activity [GO:0001727]; small GTPase binding [GO:0031267]; sphingosine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036] TLPAPAR;VNGGGGR 2 2.3 0.17305 0.34387 0 0 7.95105 9.84471 9.47078 8.60685 10.8389 0 8.73508 0 9.07195 0 Q9NRA1 PDGFC_HUMAN "Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]" PDGFC SCDGF UNQ174/PRO200 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; central nervous system development [GO:0007417]; digestive tract development [GO:0048565]; fibroblast proliferation [GO:0048144]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803] CGGNCACCLHNCNECQCVPSK;GNQIRIR 2 8.1 0.94151 -0.60576 7.74598 0 0 0 0 0 0 0 0 0 0 0 Q9NRA2 S17A5_HUMAN Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) SLC17A5 Homo sapiens (Human) amino acid transport [GO:0006865]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538] NQLSSQKSVPWVPILK 1 3.2 0.81217 -0.013481 0 0 0 6.20128 0 0 0 0 0 0 0 0 Q9NRA8 4ET_HUMAN Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4ENIF1 Homo sapiens (Human) miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA stabilization [GO:0048255]; negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106289]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; protein import into nucleus [GO:0006606]; stem cell population maintenance [GO:0019827]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605] kinase binding [GO:0019900]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723] EQDYRPK;GLKVDQQVK 2 1.6 0.97826 -2.1292 0 12.5882 0 0 0 0 0 0 0 0 0 0 Q9NRC1 ST7_HUMAN Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG) ST7 FAM4A1 HELG RAY1 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; regulation of cell differentiation [GO:0045595] membrane [GO:0016020] MMRDLMK;QSVSECKVWRNPLNLFR;VESILPSSLWHQLTRI;VEVPLIASSTIWEIKLLPK 4 11 0.96423 -1.2068 0 0 0 5.87039 0 0 0 0 7.23074 4.14796 0 0 Q9NRC6 SPTN5_HUMAN "Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)" SPTBN5 BSPECV HUBSPECV HUSPECV Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041] apical cortex [GO:0045179]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; opsin binding [GO:0002046]; spectrin binding [GO:0030507] ASCGQDQAAAETLLRR;ELEAMEK;EVGRLCQR;LAGTLER;LEATKRDLEAFSPR;LGMLEAGILPQEGR;LLSTLGPR;QQNFQAELDASMHQQQELQR;QQWLQEGLELQK;RHQQLESESRTLAAK;RHVRLER;SLREPLQERR;VLAQLQAVR;VLEEKFDAFRK;VLGQQGQELKVLWEQR;VVQERLR;WIAEKQMQLEAR 17 5.2 0.97809 -8.0616 0 14.0226 14.6166 12.6544 3.18598 12.8402 0 11.8327 5.84679 0 15.8061 13.3522 Q9NRC8 SIR7_HUMAN NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) SIRT7 SIR2L7 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; epigenetic regulation of gene expression [GO:0040029]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein depropionylation [GO:0106230]; R-loop processing [GO:0062176]; regulation of DNA repair [GO:0006282]; regulation of mitochondrion organization [GO:0010821]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; rRNA transcription [GO:0009303]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transposable element silencing [GO:0010526] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleolus organizer region [GO:0005731]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] "chromatin binding [GO:0003682]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein-lysine depropionylase activity [GO:0106231]; protein methyltransferase activity [GO:0008276]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]" AAAERSAEEGR;SPSACPQVSRILR 2 7.5 0.94405 -0.62917 0 0 7.64313 0 0 0 0 0 0 0 0 8.77149 Q9NRD0 FBX8_HUMAN F-box only protein 8 (F-box/SEC7 protein FBS) FBXO8 FBS FBX8 DC10 UNQ1877/PRO4320 Homo sapiens (Human) regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin ligase complex [GO:0000151] guanyl-nucleotide exchange factor activity [GO:0005085] GILDDSPKEIAK 1 3.8 0.92401 -0.44862 0 0 0 0 0 0 0 0 7.51302 0 0 0 Q9NRD1 FBX6_HUMAN F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2) FBXO6 FBG2 FBS2 FBX6 Homo sapiens (Human) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to unfolded protein [GO:0006986]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum quality control compartment [GO:0044322]; SCF ubiquitin ligase complex [GO:0019005] carbohydrate binding [GO:0030246]; ubiquitin protein ligase activity [GO:0061630] NPCAEEDMFAWQIDFNGGDR 1 6.8 0.64078 0.17351 0 0 0 0 0 0 0 0 0 0 6.99661 0 Q9NRD5 PICK1_HUMAN PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) PICK1 PRKCABP Homo sapiens (Human) cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; neuronal ion channel clustering [GO:0045161]; positive regulation of receptor internalization [GO:0002092]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; signaling receptor binding [GO:0005102] GAAGPLDK;GGSWCDS;SIEKFGIRLLK;YLDVKFEYLSYCLK 4 9.6 0.95537 -0.83168 9.99039 10.3776 9.32287 10.804 10.8685 10.943 8.88209 0 4.25346 12.5905 12.2968 10.7306 Q9NRD8 DUOX2_HUMAN Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase) DUOX2 LNOX2 THOX2 Homo sapiens (Human) cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590] anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175] DIFKQNISCR;FVENYRR;GCRTLLLKIPK;HLTVLRVVQLQPLQQVNLILSNNR;ILEIFFR;LSNAATR;RFVENYR;SRWDPETGR 8 4.9 0.97326 -2.9107 0 7.18953 0 0 0 0 11.6591 10.9164 0 0 0 10.1402 Q9NRD9 DUOX1_HUMAN Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) DUOX1 DUOX LNOX1 THOX1 Homo sapiens (Human) cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175] ALRVCNSYWSR;GVEVPEVIK;SRWDPETGR;TIQLQPPQKVNFVLSSNR;VTSFQPLLFTEAHREK 5 4.1 0.93668 -0.55744 0 0 0 0 11.6527 8.29921 0 0 0 0 0 0 Q9NRE1 MMP26_HUMAN Matrix metalloproteinase-26 (MMP-26) (EC 3.4.24.-) (Endometase) (Matrilysin-2) MMP26 Homo sapiens (Human) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response [GO:0050728]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] IQHLYGEK 1 3.1 0.92011 -0.43777 0 0 0 0 0 0 0 0 0 10.7634 0 0 Q9NRE2 TSH2_HUMAN Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218) TSHZ2 C20orf17 TSH2 ZNF218 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" AAGYAQEEQLKEEEEIK 1 1.6 0.9354 -0.53508 0 0 0 0 9.47336 0 0 0 0 0 0 0 Q9NRF2 SH2B1_HUMAN "SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)" SH2B1 KIAA1299 SH2B Homo sapiens (Human) cell motility [GO:0048870]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of DNA biosynthetic process [GO:2000278] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] EFCESHARAAALDFAR 1 2.1 0.91552 -0.43413 0 0 0 0 0 0 4.71869 0 0 0 0 0 Q9NRF8 PYRG2_HUMAN CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) CTPS2 Homo sapiens (Human) 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide metabolic process [GO:0006220] cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802] ICSIALVGKYTKLR 1 2.4 0.86867 -0.090754 0 0 0 8.04056 0 0 0 0 0 0 0 0 Q9NRF9 DPOE3_HUMAN DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) POLE3 CHRAC17 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; heterochromatin formation [GO:0031507]; leading strand elongation [GO:0006272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275] ATAC complex [GO:0140672]; CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] chromatin DNA binding [GO:0031490]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982] DEDNDEDEER;FVTPLKEALEAYRR 2 16.3 0.96632 -1.2724 0 0 0 0 0 0 0 4.85709 0 0 0 9.1145 Q9NRG0 CHRC1_HUMAN Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) CHRAC1 CHRAC15 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275] CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982] EEDEENDNDNESDHDEADS;EEKREEDEENDNDNESDHDEADS;EKKVLTYSDLANTAQQSETFQFLADILPK;ILASKYLK;REEDEENDNDNESDHDEADS 5 45.8 0.955 -0.83303 9.98513 9.85887 9.80462 7.30788 7.89524 7.90851 8.77357 9.66046 7.97636 9.62673 7.472 9.09614 Q9NRG1 PRDC1_HUMAN Phosphoribosyltransferase domain-containing protein 1 PRTFDC1 HHGP Homo sapiens (Human) purine ribonucleoside salvage [GO:0006166] cytosol [GO:0005829] magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803] DIGYSDIMVLCVLK 1 6.2 0.78461 0.029118 0 0 0 0 6.64501 0 0 0 0 0 0 0 Q9NRG4 SMYD2_HUMAN N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2) SMYD2 KMT3C Homo sapiens (Human) "heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 trimethyltransferase activity [GO:0140999]; lysine N-methyltransferase activity [GO:0016278]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II complex binding [GO:0000993] DSYFFTCECQECTTKDKDK;EFESHLDKLDNEK;HYPLYSLNVASMWLKLGRLYMGLEHK;LLAVKEFESHLDK;VEIRKLSDPPK 5 17.1 0.95233 -0.74376 0 10.0304 11.8094 0 8.13407 0 0 9.50601 0 0 5.71584 0 Q9NRG9 AAAS_HUMAN Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) fertilization [GO:0009566]; glutathione metabolic process [GO:0006749]; learning [GO:0007612]; microtubule bundle formation [GO:0001578]; mitotic spindle assembly [GO:0090307]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of nucleocytoplasmic transport [GO:0046822]; response to oxidative stress [GO:0006979] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] SEDLIAEFAQVTNCTIVPSLKHRLQR;VWDVSTETCVPLPWFR 2 8.2 0.44307 0.19435 0 0 0 0 0 0 13.559 0 0 0 8.49721 0 Q9NRH2 SNRK_HUMAN SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EIQTRSASPSNIK;IAGLYDLDK;LVQHPNIVR;MNIASPGTVHKRYHR;TLGRGHFAVVKLAR;VEEDEEEDEEDK 6 9.4 0.961 -1.063 5.84827 0 0 0 0 0 11.2127 0 10.1294 6.0626 0 0 Q9NRI5 DISC1_HUMAN Disrupted in schizophrenia 1 protein DISC1 KIAA0457 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in forebrain [GO:0021846]; cilium assembly [GO:0060271]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; positive regulation of axon extension [GO:0045773]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to centrosome [GO:0071539]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of dendritic spine development [GO:0060998]; regulation of postsynapse organization [GO:0099175]; regulation of synapse maturation [GO:0090128]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to electrical stimulus [GO:0051602]; TOR signaling [GO:0031929]; ubiquitin-dependent protein catabolic process [GO:0006511]" cell body [GO:0044297]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; dynein complex [GO:0030286]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intermediate filament cytoskeleton [GO:0045111]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021] identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877] MFVLEAKDQQLRR;MPGGGPQGAPAAAGGGGVSHRAGSR;VSADLAQAAR;YCDAESWTQR 4 8.6 0.81175 0.0039605 0 0 0 0 0 0 0 0 6.63054 0 0 0 Q9NRI5 DISC1_HUMAN Disrupted in schizophrenia 1 protein DISC1 KIAA0457 Homo sapiens (Human) "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in forebrain [GO:0021846]; cilium assembly [GO:0060271]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; positive regulation of axon extension [GO:0045773]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to centrosome [GO:0071539]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of dendritic spine development [GO:0060998]; regulation of postsynapse organization [GO:0099175]; regulation of synapse maturation [GO:0090128]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to electrical stimulus [GO:0051602]; TOR signaling [GO:0031929]; ubiquitin-dependent protein catabolic process [GO:0006511]" cell body [GO:0044297]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytosol [GO:0005829]; dynein complex [GO:0030286]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intermediate filament cytoskeleton [GO:0045111]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021] identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877] ALQDTLASAGQIPFHAEPPETIRR;MFVLEAKDQQLRR;MPGGGPQGAPAAAGGGGVSHRAGSR;VSADLAQAAR 4 12.9 0.88012 -0.15386 12.9398 0 0 0 0 5.32431 0 0 0 0 0 11.2761 Q9NRJ3 CCL28_HUMAN C-C motif chemokine 28 (Mucosae-associated epithelial chemokine) (MEC) (Protein CCK1) (Small-inducible cytokine A28) CCL28 SCYA28 Homo sapiens (Human) cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; immune response [GO:0006955]; negative regulation of leukocyte tethering or rolling [GO:1903237]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to nutrient [GO:0007584] extracellular exosome [GO:0070062]; extracellular region [GO:0005576] chemokine activity [GO:0008009] LLERVNMCRIQR;VQAAKKNGK 2 16.5 0.97892 -1.9029 0 0 0 0 0 0 0 0 11.9165 0 0 0 Q9NRJ4 TULP4_HUMAN Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) TULP4 KIAA1397 TUBL4 TUSP Homo sapiens (Human) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829] EATLKMAQLADSPRAPLQPLAK;TRMLCSQNTYTLPGPGSSATLRLTATEK;VTQESAKNFQIELEGR 3 4.3 0.93674 -0.54513 0 0 11.9855 0 10.8859 0 0 8.64886 0 0 0 0 Q9NRJ7 PCDBG_HUMAN Protocadherin beta-16 (PCDH-beta-16) (Protocadherin-3X) PCDHB16 KIAA1621 PCDH3X Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] DLGLGLTEMSTRK;SGTAQVR;VLIHEFRDGRK 3 4 0.95401 -0.88986 0 0 12.1003 9.03373 0 0 0 0 0 0 0 0 Q9NRK6 ABCBA_HUMAN "ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (EC 7.6.2.-) (Mitochondrial ATP-binding cassette 2) (M-ABC2)" ABCB10 Homo sapiens (Human) erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803] LWELLEREPK 1 1.4 0.88593 -0.18206 0 0 0 0 8.252 0 0 0 0 0 0 0 Q9NRL2 BAZ1A_HUMAN Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of heterochromatin formation [GO:0031445]; regulation of transcription by RNA polymerase II [GO:0006357] ACF complex [GO:0016590]; CHRAC [GO:0008623]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IVEEERLK;KINSAPPTETKSLR;LGLHVTPSNVDQVSTPPAAK;LLKQEEMKSLAFEK;LSSSFSSR;LSSTSVYDLTPGEK 6 5 0.77834 0.038461 10.1912 14.1777 13.8858 10.7484 11.0144 9.79821 9.00039 0 12.0371 12.1285 0 0 Q9NRL3 STRN4_HUMAN Striatin-4 (Zinedin) STRN4 ZIN Homo sapiens (Human) negative regulation of hippo signaling [GO:0035331]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674] EGRQLLRQYLEEVGYTDTILDMR;TWNPKFTLR 2 4.2 0.86615 -0.091958 0 0 0 0 0 0 0 0 0 0 0 3.96375 Q9NRM0 GTR9_HUMAN "Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter)" SLC2A9 GLUT9 Homo sapiens (Human) D-glucose transmembrane transport [GO:1904659]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]; urate metabolic process [GO:0046415]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate:proton symporter activity [GO:0005351]; D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] RNKAYPPEEK;SIRLVSVLELLRAPYVR 2 5 0.95523 -0.97858 0 0 0 0 0 0 0 5.13951 0 0 0 0 Q9NRM1 ENAM_HUMAN Enamelin ENAM Homo sapiens (Human) ameloblast differentiation [GO:0036305]; amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; positive regulation of enamel mineralization [GO:0070175] endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] structural constituent of tooth enamel [GO:0030345] EIMPFPEASSLQSKNTPCLK;ENHPYPNIR 2 2.5 0.95292 -0.67362 0 0 0 8.93593 0 0 0 0 10.8606 0 0 0 Q9NRM2 ZN277_HUMAN Zinc finger protein 277 (Nuclear receptor-interacting factor 4) ZNF277 NRIF4 ZNF277P Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LVNFIRR 1 1.6 0.78488 0.021087 0 0 0 8.87424 0 0 0 0 0 0 0 0 Q9NRM6 I17RB_HUMAN Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor) IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612 Homo sapiens (Human) defense response [GO:0006952]; regulation of cell growth [GO:0001558] extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-17 receptor activity [GO:0030368] SNFQSYSCVRCNYTEAFQTQTRPSGGK;SQACHDGCCSL 2 7.6 0.94591 -0.65291 0 0 6.2582 0 0 0 0 0 0 0 0 0 Q9NRM7 LATS2_HUMAN Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) LATS2 KPM Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of organ growth [GO:0046620]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] MRPKTFPATTYSGNSR;VDTHALYAMK 2 2.4 0.95086 -0.66944 0 0 0 0 0 0 0 0 0 0 9.34738 0 Q9NRN5 OLFL3_HUMAN Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44) OLFML3 PSEC0035 PSEC0173 PSEC0244 UNQ663/PRO1294 Homo sapiens (Human) signal transduction [GO:0007165] extracellular space [GO:0005615]; extracellular vesicle [GO:1903561] ARIQCSFDASGTLTPER 1 4.2 0.82297 -0.018283 0 7.5979 0 0 0 0 0 0 0 0 0 0 Q9NRN7 ADPPT_HUMAN L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog) AASDHPPT CGI-80 HAH-P HSPC223 x0005 Homo sapiens (Human) 10-formyltetrahydrofolate catabolic process [GO:0009258]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; pantothenate metabolic process [GO:0015939]; protein maturation [GO:0051604] cytosol [GO:0005829]; extracellular exosome [GO:0070062] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] FCLVPSMEGVRWAFSCGTWLPSR;LFLDGEEEKEWAFEESKIDEHHFVAVALR 2 16.8 0.97391 -1.4196 0 0 14.0563 0 0 0 13.2807 0 13.7598 0 6.50957 0 Q9NRP0 OSTC_HUMAN Oligosaccharyltransferase complex subunit OSTC (Hydrophobic protein HSF-28) OSTC DC2 HDCMD45P HSPC307 Homo sapiens (Human) protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250] FLLLFIGFVCVLLSFFMAR 1 12.8 0.65275 0.16997 0 0 0 0 0 0 0 0 0 8.53706 0 0 Q9NRP4 SDHF3_HUMAN "Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)" SDHAF3 ACN9 DC11 Homo sapiens (Human) mitochondrial respiratory chain complex II assembly [GO:0034553]; regulation of gluconeogenesis [GO:0006111]; succinate metabolic process [GO:0006105] mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] QFSISESMKPKF 1 9.6 0.67429 0.16684 7.53037 0 7.19436 0 0 0 0 0 0 0 0 0 Q9NRP7 STK36_HUMAN Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) STK36 KIAA1278 Homo sapiens (Human) axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of DNA-binding transcription factor activity [GO:0051090]; smoothened signaling pathway [GO:0007224] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription corepressor binding [GO:0001222] EIEIMRGLR 1 0.7 0.89916 -0.2574 0 0 0 0 0 0 0 0 0 0 0 10.4404 Q9NRQ2 PLS4_HUMAN Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) PLSCR4 GIG43 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; plasma membrane phospholipid scrambling [GO:0017121] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124] CTCCCFCCPSAR;KWNGLLSAMADADHFDIHFPLDLDVKMK 2 12.2 0.86405 -0.084051 7.27426 0 0 0 5.46074 4.6597 0 0 0 0 0 0 Q9NRR4 RNC_HUMAN Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) DROSHA RN3 RNASE3L RNASEN Homo sapiens (Human) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of regulatory T cell differentiation [GO:0045589]; rRNA processing [GO:0006364] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] DEAD/H-box RNA helicase binding [GO:0017151]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332] ALVPEEEIANMLQWEELEWQKYAEECK;DILELYDWNLK;FLPDGGK;HLPPYPLPKAPSERR;LKHYDDHR 5 4.9 0.97883 -2.111 0 12.3001 11.019 6.74079 6.63865 0 0 5.22978 0 10.0296 0 0 Q9NRR6 INP5E_HUMAN "Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)" INPP5E Homo sapiens (Human) cilium assembly [GO:0060271]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein localization to cilium [GO:1903565]; negative regulation of translation [GO:0017148]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; response to inositol [GO:1902140] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]" TVQALVLPRNVPDTNPYR 1 2.8 0.88674 -0.19385 0 0 0 0 0 0 10.3171 0 0 0 0 0 Q9NRR8 C42S1_HUMAN CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (Small effector of CDC42 protein 1) CDC42SE1 SPEC1 Homo sapiens (Human) phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] SKGNRDRPWSNSR 1 16.5 0.60709 0.17657 5.78228 0 0 0 0 0 0 0 0 0 0 0 Q9NRS4 TMPS4_HUMAN Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain] TMPRSS4 TMPRSS3 UNQ776/PRO1570 Homo sapiens (Human) negative regulation of growth rate [GO:0045967]; positive regulation of viral entry into host cell [GO:0046598]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of gene expression [GO:0010468]; response to wounding [GO:0009611] extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] IIIIEFNPMYPK;VRAGSDKLGSFPSLAVAK 2 6.9 0.9545 -0.79986 12.4083 0 12.3202 9.80935 0 0 11.0229 0 0 0 0 0 Q9NRS6 SNX15_HUMAN Sorting nexin-15 SNX15 Homo sapiens (Human) intracellular protein transport [GO:0006886] cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] FTVHIPALNNSPQLKEFFRGGEVTRPLEVSR;LEEFPAFPRAQVFGR 2 13.5 0.93618 -0.53617 0 0 0 7.09434 0 0 0 0 0 11.3079 0 0 Q9NRU3 CNNM1_HUMAN Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1) CNNM1 ACDP1 Homo sapiens (Human) magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] ILLRLLKHPNVIQELK;LDTVLEEFK;LLKHPNVIQELK;SPSRCSGLNRSESPNR;TLSGQKRK;VEVEVGK 6 5.9 0.97209 -2.7144 12.8979 0 9.46373 0 0 5.5941 0 5.09153 0 0 9.91482 0 Q9NRV9 HEBP1_HUMAN Heme-binding protein 1 (p22HBP) HEBP1 HBP Homo sapiens (Human) circadian rhythm [GO:0007623] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739] heme binding [GO:0020037] EADYVAQATR;EAMPKVAK;GDKEEVAYEERACEGGK 3 18.5 0.9664 -1.272 0 9.78627 0 0 0 5.2598 0 0 0 9.40369 0 0 Q9NRW1 RAB6B_HUMAN Ras-related protein Rab-6B (EC 3.6.5.2) RAB6B Homo sapiens (Human) "Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; neuron projection development [GO:0031175]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; presynapse [GO:0098793] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] EGMIDIK;LQLWDTAGQER;TVRLQLWDTAGQER 3 10.1 0.015534 0.76075 0 13.5006 11.5388 0 0 0 11.1015 11.1291 11.1986 6.97934 9.86697 0 Q9NRW4 DUS22_HUMAN Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) DUSP22 JSP1 LMWDSP2 MKPX Homo sapiens (Human) cellular response to epidermal growth factor stimulus [GO:0071364]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of JNK cascade [GO:0046330]; regulation of cell population proliferation [GO:0042127]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; leading edge of lamellipodium [GO:0061851]; plasma membrane [GO:0005886] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine kinase inhibitor activity [GO:0030292]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" HEVHQYRQWLKEEYGESPLQDAEEAK;TEPQPGAR 2 16.6 0.26675 0.26735 10.6922 0 0 0 0 0 9.16922 0 9.67719 0 0 0 Q9NRW7 VPS45_HUMAN Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) VPS45 VPS45A VPS45B Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021] ENVDYIIQELR;EYELFEFR;IDSQNREIMK;NVVFAVKQYISK 4 7.2 0.92432 -0.44874 0 0 0 8.00736 0 0 0 0 0 0 0 0 Q9NRW7 VPS45_HUMAN Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) VPS45 VPS45A VPS45B Homo sapiens (Human) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021] ENVDYIIQELR;EYELFEFR;GVGEQLWVLCWLLELISR;IDSQNREIMK 4 8.7 0.97816 -2.1397 0 0 0 9.94182 6.40417 10.4085 0 14.4615 14.4325 0 0 13.3123 Q9NRX1 PNO1_HUMAN RNA-binding protein PNO1 (Partner of NOB1) PNO1 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] NVEIRTCK;TCKETKDVSALTK 2 7.1 0.97602 -1.4494 0 0 7.35755 0 10.2369 0 0 0 0 0 0 0 Q9NRX2 RM17_HUMAN "Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (LYST-interacting protein 2)" MRPL17 LIP2 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735] DLIPKLFQVLAPRYK 1 8.6 0.96303 -1.0812 0 0 0 0 0 0 0 0 0 0 6.99232 0 Q9NRX4 PHP14_HUMAN 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) PHPT1 PHP14 CGI-202 HSPC141 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; lamellipodium organization [GO:0097581]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; protein dephosphorylation [GO:0006470] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; leading edge of lamellipodium [GO:0061851]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; protein histidine phosphatase activity [GO:0101006]; transmembrane transporter binding [GO:0044325] EIVRGYK 1 5.6 0.98064 -1.622 0 0 0 0 0 0 0 0 0 0 11.7046 0 Q9NRX5 SERC1_HUMAN Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732 Homo sapiens (Human) membrane biogenesis [GO:0044091]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; sphingolipid metabolic process [GO:0006665] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] acetyltransferase activator activity [GO:0010698]; protein-macromolecule adaptor activity [GO:0030674] CCPSGNNSTVTR 1 2.6 0.89797 -0.23826 0 0 0 0 0 0 0 0 7.03837 0 0 0 Q9NRY4 RHG35_HUMAN Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP Homo sapiens (Human) "axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; central nervous system neuron axonogenesis [GO:0021955]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; forebrain development [GO:0030900]; mammary gland development [GO:0030879]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vascular permeability [GO:0043116]; neural tube closure [GO:0001843]; neuron projection guidance [GO:0097485]; positive regulation of cilium assembly [GO:0045724]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; phospholipid binding [GO:0005543] DAHTFALSKK;IELSVLSYHSSFSIR;LEIFHPFFK;LPVNSFQTPTFQPHGCLCLYNSK;RNTKKPKPKPRPSITK;SRLVHGYIVFYSAKR 6 5.9 0.93292 -0.50933 0 0 6.16525 0 10.359 0 4.07664 7.8586 9.8222 0 0 0 Q9NRY6 PLS3_HUMAN Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) PLSCR3 Homo sapiens (Human) apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124] AGYLPPK 1 2.4 0.94118 -0.58955 0 0 0 0 10.4213 0 0 0 0 0 0 0 Q9NRZ5 PLCD_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 4) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acid acyltransferase delta) (LPAAT-delta) AGPAT4 UNQ499/PRO1016 Homo sapiens (Human) CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] DAFQEEYYR;GSAYGNSDSK;HEISMQVARAKGLPR 3 9 0.97932 -1.879 0 0 5.94636 10.5823 0 8.41011 0 0 0 0 0 0 Q9NRZ7 PLCC_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 3) (1-AGP acyltransferase 3) (1-AGPAT 3) (Lysophosphatidic acid acyltransferase gamma) (LPAAT-gamma) AGPAT3 LPAAT3 UNQ759/PRO1490 Homo sapiens (Human) CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] CLLWALPDHPR;CLLWALPDHPRRR;HRVSMEVAAAK 3 6.1 0.8766 -0.12454 0 0 13.5062 0 0 0 0 10.5093 0 0 3.6153 0 Q9NRZ9 HELLS_HUMAN Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) HELLS PASG SMARCA6 Nbla10143 Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; kidney development [GO:0001822]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; pericentric heterochromatin formation [GO:0031508]; urogenital system development [GO:0001655] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" ATP binding [GO:0005524]; chromatin binding [GO:0003682]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] ETIELSPTGRPKRR;FLLTKMEQQQLEEQK;LILTPFLLRRLK 3 5.8 0.88825 -0.20343 0 0 0 0 0 8.5225 0 0 0 0 0 0 Q9NS00 C1GLT_HUMAN "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Homo sapiens (Human) angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] DTIGKETFHPFVPEHHLIKGYLPR;EALKRFVDAFK 2 9.6 0.97329 -2.637 0 0 0 0 0 0 8.72212 0 0 0 9.68865 0 Q9NS15 LTBP3_HUMAN Latent-transforming growth factor beta-binding protein 3 (LTBP-3) LTBP3 Homo sapiens (Human) bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; chondrocyte differentiation [GO:0002062]; lung saccule development [GO:0060430]; negative regulation of bone mineralization [GO:0030502]; negative regulation of chondrocyte differentiation [GO:0032331]; positive regulation of bone resorption [GO:0045780]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; transforming growth factor beta binding [GO:0050431] DEDSSEEDSDECR;DIDECMLFGSEICK;DIDECMLFGSEICKEGK;GAAGGLAPEMR;LTRQLCCCSVGK;SHCEDIDECDFPAACIGGDCINTNGSYR 6 6.2 0.96448 -1.117 5.83777 8.66217 0 0 0 0 9.42515 0 0 8.78329 0 0 Q9NS23 RASF1_HUMAN Ras association domain-containing protein 1 RASSF1 RDA32 Homo sapiens (Human) DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] ALSFVLK;GLQCAHCKFTCHYR;LLDDEQPLRLR;LVRPVSVPSSK 4 12.6 0.95547 -0.80901 0 0 8.04691 0 6.16958 0 0 0 0 0 8.88173 0 Q9NS28 RGS18_HUMAN Regulator of G-protein signaling 18 (RGS18) RGS18 RGS13 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] EVNLDFHTK;FIQTDAPK 2 7.2 0.96529 -1.159 0 0 0 0 0 0 0 10.5167 0 0 0 0 Q9NS39 RED2_HUMAN Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) ADARB2 ADAR3 RED2 Homo sapiens (Human) adenosine to inosine editing [GO:0006382]; mRNA processing [GO:0006397]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nucleolus [GO:0005730] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; tRNA-specific adenosine deaminase activity [GO:0008251] FRGHLRTK;GGAPGAK;YVCLAEPAERR 3 3.5 0.9763 -1.48 0 0 0 8.96587 0 0 0 0 0 0 12.9962 0 Q9NS40 KCNH7_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Potassium voltage-gated channel subfamily H member 7) (Voltage-gated potassium channel subunit Kv11.3) KCNH7 ERG3 Homo sapiens (Human) circadian rhythm [GO:0007623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] heme binding [GO:0020037]; inward rectifier potassium channel activity [GO:0005242]; protein-containing complex binding [GO:0044877] LKSKESLSSGVHLNTASEDNLTSLLK;SRESLCSIRR 2 3 0.77559 0.045248 9.8484 0 0 0 0 0 0 0 0 0 0 0 Q9NS40 KCNH7_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Potassium voltage-gated channel subfamily H member 7) (Voltage-gated potassium channel subunit Kv11.3) KCNH7 ERG3 Homo sapiens (Human) circadian rhythm [GO:0007623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] heme binding [GO:0020037]; inward rectifier potassium channel activity [GO:0005242]; protein-containing complex binding [GO:0044877] NIFRDRHASEGPFNHIK;SRESLCSIRR 2 3.7 0.82858 -0.023413 0 0 0 9.25524 8.63822 0 0 0 0 0 0 0 Q9NS56 TOPRS_HUMAN E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) TOPORS LUN TP53BPL Homo sapiens (Human) DNA damage response [GO:0006974]; DNA-templated transcription [GO:0006351]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of apoptotic process [GO:0043066]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; ubiquitin-dependent protein catabolic process [GO:0006511] centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DVEIPQFMR;NESDTFSDSRSSDR;STSLSSPRNLNSSVRGDR;VQSFSERTNAR 4 5 0.96508 -1.1628 13.7776 0 0 0 0 0 8.78872 0 0 0 9.84817 0 Q9NS61 KCIP2_HUMAN A-type potassium channel modulatory protein KCNIP2 (Cardiac voltage-gated potassium channel modulatory subunit) (Kv channel-interacting protein 2) (KChIP2) (Potassium channel-interacting protein 2) KCNIP2 KCHIP2 Homo sapiens (Human) action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; clustering of voltage-gated potassium channels [GO:0045163]; detection of calcium ion [GO:0005513]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; muscle contraction [GO:0006936]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; potassium ion transport [GO:0006813]; regulation of heart contraction [GO:0008016]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion export across plasma membrane [GO:1903764]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; dendrite [GO:0030425]; Kv4.2-KChIP2 channel complex [GO:0071193]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; ER retention sequence binding [GO:0046923]; identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325] SCTGASRTNVPAELSMRR 1 10.2 0.50788 0.18791 0 9.11754 0 0 0 0 0 0 0 0 0 0 Q9NS69 TOM22_HUMAN Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog) TOMM22 TOM22 Homo sapiens (Human) protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320] AAAVAAAGAGEPQSPDELLPK 1 14.8 0 10.05 0 0 0 0 0 0 0 0 0 0 10.0197 0 Q9NS73 MBIP1_HUMAN MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) MBIP BM-015 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein kinase inhibitor activity [GO:0004860] ILELEGISPEYFQSVSL;LQNIEAHLRLQTGGPVPR 2 11.7 0.71196 0.1523 14.434 0 0 0 0 7.94087 0 5.30852 0 0 0 0 Q9NS75 CLTR2_HUMAN Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321) CYSLTR2 CYSLT2 CYSLT2R PSEC0146 Homo sapiens (Human) immune response [GO:0006955]; neuropeptide signaling pathway [GO:0007218] plasma membrane [GO:0005886] cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974] GHPQKAK 1 2 0.9811 -1.5757 0 0 0 9.48148 0 0 0 0 0 0 0 0 Q9NS84 CHST7_HUMAN Carbohydrate sulfotransferase 7 (EC 2.8.2.-) (EC 2.8.2.17) (Chondroitin 6-sulfotransferase 2) (C6ST-2) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5) (GST-5) (N-acetylglucosamine 6-O-sulfotransferase 4) (GlcNAc6ST-4) (Gn6st-4) CHST7 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790] Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517] SLFRCDFSVLR 1 2.3 0.97597 -1.4523 0 0 0 0 0 0 0 0 0 9.11111 0 0 Q9NS86 LANC2_HUMAN LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) LANCL2 GPR69B TASP Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; negative regulation of DNA-templated transcription [GO:0045892]; peptide modification [GO:0031179]; positive regulation of abscisic acid-activated signaling pathway [GO:0009789] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] DLLQQMEEGLK;EAMECSDVIWQR;VTCDQTYLLRSLDYVKR 3 8.9 0.95184 -0.71298 0 0 0 0 9.79487 7.19121 0 0 0 4.36093 0 0 Q9NS87 KIF15_HUMAN Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) KIF15 KLP2 KNSL7 Homo sapiens (Human) centrosome separation [GO:0051299]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; plus-end kinesin complex [GO:0005873]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] ADLEEVQSALYNKEMECLR;ERTSQEMEMLR;EVKNAEILR;IVEEMLK;IVEEMLKMKADLEEVQSALYNK;LEEMYEER;LEYSSFKTNQEKEFNK;LQQHVDK;LVGHQNLHQKIQYVVRLK;VASTSMNR;VASTSMNRESSR;VLIKKQEVDILDLK 12 8.9 0.97591 -5.0597 0 12.5908 0 13.2992 10.9468 0 14.5089 0 14.5735 11.7587 13.1404 0 Q9NS87 KIF15_HUMAN Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) KIF15 KLP2 KNSL7 Homo sapiens (Human) centrosome separation [GO:0051299]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; plus-end kinesin complex [GO:0005873]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] EVKNAEILR;GSRTEEEEYNFKMR;LEYSSFKTNQEKEFNK;LQQHVDK;VASTSMNR;VASTSMNRESSR;VLIKKQEVDILDLK 7 6 0.86493 -0.087266 0 0 0 0 0 0 0 0 0 9.21902 0 0 Q9NS91 RAD18_HUMAN E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) RAD18 RNF73 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; replication fork [GO:0005657]; site of double-strand break [GO:0035861] damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; Y-form DNA binding [GO:0000403] LNESVMVFTK;NDLQDTEISPRQNR 2 4.8 0.96139 -1.0639 0 0 0 0 0 0 0 0 0 0 0 4.24085 Q9NS93 TM7S3_HUMAN Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) TM7SF3 Homo sapiens (Human) cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] RALNKDFHR;VAGAAEVFGNSSEGLIEFSVGKFR 2 5.8 0.97626 -1.467 0 0 0 10.2704 0 0 0 11.2637 0 0 6.12449 0 Q9NS98 SEM3G_HUMAN Semaphorin-3G (Semaphorin sem2) SEMA3G Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215]; signaling receptor binding [GO:0005102] GTTECSGCFRSR;SRVHAEHNR;SRVHAEHNRTPR;VHAEHNRTPREVEAT;WLLQRPGDEGPDQVK 5 5.6 0.97243 -2.8202 7.92855 6.9148 0 9.84966 0 0 0 6.58396 9.82855 0 0 8.21276 Q9NSB2 KRT84_HUMAN "Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)" KRT84 KRTHB4 Homo sapiens (Human) hair follicle development [GO:0001942]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; nail development [GO:0035878]; regulation of keratinocyte differentiation [GO:0045616] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] AQYEEVAR;FASFIDK;FASFIDKVR;FLEQQNK;LLEGEESR;NEINELTR;WSFLQEQK;WSFLQEQKCIR 8 8.5 0.974 -1.4117 0 14.2967 0 0 9.54865 9.66066 10.6995 0 0 12.57 0 11.6193 Q9NSB4 KRT82_HUMAN "Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)" KRT82 KRTHB2 Homo sapiens (Human) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] FASFINKVR;VTAGNHCDNLR 2 3.9 0.97092 -1.3416 5.71828 0 0 0 0 0 0 0 0 0 0 0 Q9NSB8 HOME2_HUMAN Homer protein homolog 2 (Homer-2) (Cupidin) HOMER2 Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; calcium-mediated signaling [GO:0019722]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of store-operated calcium entry [GO:2001256]; sensory perception of sound [GO:0007605] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; stereocilium tip [GO:0032426] actin binding [GO:0003779]; G protein-coupled glutamate receptor binding [GO:0035256]; synaptic receptor adaptor activity [GO:0030160] ASHAGPANTHLKSENDK;EKEKNTQLK;IEELEAELREKETELK 3 11.9 0.97872 -1.9677 0 0 0 0 0 0 0 0 0 0 10.2859 0 Q9NSC5 HOME3_HUMAN Homer protein homolog 3 (Homer-3) HOMER3 Homo sapiens (Human) G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; protein targeting [GO:0006605]; regulation of store-operated calcium entry [GO:2001256] basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled glutamate receptor binding [GO:0035256]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] AMERSLEEAR;SLEEARAER 2 3.6 0.97213 -2.8266 0 12.5358 0 0 0 0 0 0 0 0 0 0 Q9NSC7 SIA7A_HUMAN "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A)" ST6GALNAC1 SIAT7A UNQ543/PRO848 Homo sapiens (Human) host-mediated regulation of intestinal microbiota composition [GO:0048874]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]" RSCLWRCR;SLQSLAKPKSQAPTRAR;TEAQSWK 3 5.3 0.97955 -1.5376 0 11.0887 0 0 0 0 0 0 0 0 0 0 Q9NSD4 ZN275_HUMAN Zinc finger protein 275 ZNF275 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CECSQCGRVFK;GPSDLIK;GVAEFNEHRK;GWECGDCGK;HQRMHTGHLPFDCDDCGK;SFKVNTHLFRHQK 6 15.9 0.97479 -2.382 0 0 0 6.42435 0 0 6.44559 9.49555 7.29425 0 0 0 Q9NSD7 RL3R1_HUMAN Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor) RXFP3 GPCR135 RLN3R1 SALPR Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930] VLLGFVLPLGIIILCYLLLVR 1 4.5 0.65453 0.16939 0 0 0 0 0 0 0 9.5936 0 9.39101 0 0 Q9NSD9 SYFB_HUMAN Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) FARSB FARSLB FRSB HSPC173 Homo sapiens (Human) phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] ASEGPAFFPGR;ETPENLAK;IDVPANR;TAEFQVAR;TTLLPGLLK 5 7.3 0.9783 -2.061 0 0 0 0 10.5389 0 0 0 9.61884 0 12.6788 0 Q9NSE2 CISH_HUMAN Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS) CISH G18 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; protein ubiquitination [GO:0016567]; regulation of cell growth [GO:0001558] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytokine receptor binding [GO:0005126] LVQPFVRR 1 3.1 0.73086 0.11366 0 0 0 0 0 0 0 0 0 0 0 13.2496 Q9NSE4 SYIM_HUMAN "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" IARS2 Homo sapiens (Human) isoleucyl-tRNA aminoacylation [GO:0006428]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049] EAQNLSAMEIRKK;GPGAAALATAR;ITELYKQYDFGK;MSKSLGNVIHPDVVVNGGQDQSK;TGWISTSSIWK 5 6.9 0.97835 -2.078 0 0 0 0 0 8.66917 0 0 4.81578 0 8.9095 0 Q9NSG2 FIRRM_HUMAN FIGNL1-interacting regulator of recombination and mitosis (FIDGETIN-like-1 interacting protein) (FLIP) (POLO1-associating protein) FIRRM APOLO1 C1orf112 Homo sapiens (Human) chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; mitotic cell cycle [GO:0000278]; regulation of protein kinase activity [GO:0045859] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]" protein kinase binding [GO:0019901] LILQAVTLQTSLLK 1 1.6 0.78394 0.021207 0 0 0 0 0 0 0 0 9.63241 0 0 0 Q9NSI2 SLX9_HUMAN Ribosome biogenesis protein SLX9 homolog SLX9 C21orf70 FAM207A PRED56 Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" "90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" TRFQELLASPAYR 1 5.7 0.95261 -0.6805 12.4389 0 0 0 0 0 0 0 0 0 0 0 Q9NSI5 IGSF5_HUMAN Immunoglobulin superfamily member 5 (IgSF5) (Junctional adhesion molecule 4) (JAM-4) IGSF5 JAM4 Homo sapiens (Human) cell-cell adhesion [GO:0098609] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986] CCFCCRR;CCGCNCCCRCCFCCR;RCCGCNCCCR;RRCCGCNCCCR 4 4.4 0.89231 -0.21267 5.5168 0 8.10066 0 0 6.6565 6.6659 0 6.45176 3.91198 0 0 Q9NSI6 BRWD1_HUMAN Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) BRWD1 C21orf107 WDR9 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] axoneme [GO:0005930]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; motile cilium [GO:0031514]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] HETSCDQSEGSGSSEEDEWR;IMLSAGHDGSIFIWDITKGTKMK;KYPNYGRR;LEDFRLEKGEEER;NNIYELNPNKEPWR;QMHQNAPRSQIATER;SIRATNYVESNWKK;TGHRIFTGSDDCLVKIWSTHNGR;TSSGRRR;VTRTRAAQR 10 6.4 0.97516 -3.2904 0 0 0 8.10224 6.96751 0 0 8.85888 12.6922 0 8.94005 11.3183 Q9NSK0 KLC4_HUMAN Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) KLC4 KNSL8 Homo sapiens (Human) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] kinesin binding [GO:0019894] AQVRRLCQENQWLR;EKVLGTNHPDVAK;LEAAETLEECALRSR;QALEDLERTSGR;RLCQENQWLRDELAGTQQR;VPQARMSGLVLGQR;YEVAVPLCK 7 13.5 0.97306 -2.8564 0 0 0 12.2173 11.9576 12.1548 0 0 0 13.825 13.3056 9.65726 Q9NSN8 SNTG1_HUMAN Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) SNTG1 Homo sapiens (Human) cell communication [GO:0007154] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; syntrophin complex [GO:0016013] actin binding [GO:0003779]; structural molecule activity [GO:0005198] TFSVYEIMCK 1 1.9 0.80223 0.01433 0 0 0 0 0 0 0 0 0 4.32481 0 0 Q9NSP4 CENPM_HUMAN Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1) CENPM C22orf18 ICEN39 PANE1 Homo sapiens (Human) chromosome segregation [GO:0007059] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] SLPLPSSVNRPRIDLIVFVVNLHSK 1 13.9 0.83852 -0.039211 0 0 0 0 4.71929 0 0 0 0 0 0 0 Q9NSQ0 RRP7B_HUMAN Putative ribosomal RNA-processing protein 7 homolog B (Putative gastric cancer antigen Zg14-like protein) RRP7BP RRP7B Homo sapiens (Human) ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364] CURI complex [GO:0032545]; UTP-C complex [GO:0034456] SQKELLNYAWQHR 1 12.6 0.91708 -0.42967 0 0 0 0 0 0 0 0 0 0 0 10.6798 Q9NST1 PLPL3_HUMAN 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3) PNPLA3 ADPN C22orf20 Homo sapiens (Human) "acylglycerol acyl-chain remodeling [GO:0036155]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cellular response to insulin stimulus [GO:0032869]; glycerophospholipid metabolic process [GO:0006650]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; phosphatidic acid biosynthetic process [GO:0006654]; response to sucrose [GO:0009744]; triglyceride acyl-chain remodeling [GO:0036153]; triglyceride biosynthetic process [GO:0019432]; triglyceride catabolic process [GO:0019433]; white fat cell differentiation [GO:0050872]" cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acylglycerol O-acyltransferase activity [GO:0016411]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; long-chain fatty acyl-CoA binding [GO:0036042]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophosphatidic acid binding [GO:0035727]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; triacylglycerol lipase activity [GO:0004806] LATALSEEMKDK 1 2.5 0.88779 -0.18451 0 10.9079 0 0 0 0 0 10.4801 0 0 0 0 Q9NSV4 DIAP3_HUMAN Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) DIAPH3 DIAP3 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; autophagosome-lysosome fusion [GO:0061909]; cell projection organization [GO:0030030]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; endosomal transport [GO:0016197]; erythrocyte enucleation [GO:0043131]; establishment of cell polarity [GO:0030010]; gene expression [GO:0010467]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; inner ear receptor cell differentiation [GO:0060113]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; podosome assembly [GO:0071800]; protein-containing complex remodeling [GO:0034367]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT I complex [GO:0000813]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; ribbon synapse [GO:0097470]; spindle pole [GO:0000922]; stereocilia tip-link density [GO:1990427] actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] ELNYNLDTHTSTGR;RLRPRLSAILFK;SRQISPQEFIHELK;TLTDDMLDK;VSVETLEKNLR 5 5 0.97867 -1.9726 0 0 0 0 0 0 11.1856 5.60499 11.5787 8.02054 0 0 Q9NSV4 DIAP3_HUMAN Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) DIAPH3 DIAP3 Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; autophagosome-lysosome fusion [GO:0061909]; cell projection organization [GO:0030030]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; endosomal transport [GO:0016197]; erythrocyte enucleation [GO:0043131]; establishment of cell polarity [GO:0030010]; gene expression [GO:0010467]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; inner ear receptor cell differentiation [GO:0060113]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; podosome assembly [GO:0071800]; protein-containing complex remodeling [GO:0034367]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT I complex [GO:0000813]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; ribbon synapse [GO:0097470]; spindle pole [GO:0000922]; stereocilia tip-link density [GO:1990427] actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] GLCLFKKHFMALIFSAK;RLRPRLSAILFK 2 4.2 0.95485 -0.79697 0 0 0 0 10.6291 0 0 0 0 0 0 0 Q9NSY1 BMP2K_HUMAN BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) BMP2K BIKE HRIHFB2017 Homo sapiens (Human) positive regulation of Notch signaling pathway [GO:0045747]; regulation of bone mineralization [GO:0030500]; regulation of clathrin-dependent endocytosis [GO:2000369] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatase regulator activity [GO:0019208]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LTEEELLDR 1 0.8 0.91059 -0.29382 0 0 0 0 0 0 12.1552 10.5911 0 0 0 0 Q9NSY2 STAR5_HUMAN StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5) STARD5 Homo sapiens (Human) cholesterol import [GO:0070508] cytosol [GO:0005829] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] FYANLQKAVKQFHE 1 6.6 0.76524 0.060106 0 0 0 0 0 0 0 0 0 0 0 9.89533 Q9NT22 EMIL3_HUMAN EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5) EMILIN3 C20orf130 EMILIN5 Homo sapiens (Human) collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802] AEYRQCRWGPK 1 1.4 0.95801 -1.0012 0 0 0 0 0 0 0 0 0 0 9.66053 0 Q9NT62 ATG3_HUMAN Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) ATG3 APG3 APG3L Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of phagocytosis [GO:0050765]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017] Atg12-Atg5-Atg16 complex [GO:0034274]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407] Atg12 transferase activity [GO:0019777]; Atg8-family conjugating enzyme activity [GO:0141046]; Atg8-family ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ubiquitin-like protein transferase activity [GO:0019787] QFLVTKNVPCYK 1 3.8 0.73207 0.11783 0 5.37069 0 0 0 0 0 0 7.61036 0 0 0 Q9NT68 TEN2_HUMAN "Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]" TENM2 KIAA1127 ODZ2 TNM2 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; signal transduction [GO:0007165] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] ALGTAWAK;AYNKASGWSVQYR;LDGKEKWSVVESPR;QTAGTETDGCPDLCNGNGR;SNNPLSSELDLK;SQIHISQPQFLK;VTQEVPPGVFWRSQIHISQPQFLKFNISLGK;YPKYGYTITR 8 3.9 0.97543 -4.2393 11.2411 0 0 0 11.6567 11.8074 10.7414 0 0 7.33949 0 0 Q9NT99 LRC4B_HUMAN Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) LRRC4B LRIG4 Homo sapiens (Human) positive regulation of synapse assembly [GO:0051965]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] cerebellar mossy fiber [GO:0044300]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] signaling receptor binding [GO:0005102] DLAEVPASIPVNTR;YLNLQENGIQVIR 2 3.8 0.76466 0.062738 0 0 0 0 10.4458 7.8196 0 0 0 0 0 0 Q9NTG1 PKDRE_HUMAN Polycystin family receptor for egg jelly (PKD and REJ homolog) (Polycystic kidney disease and receptor for egg jelly-related protein) PKDREJ Homo sapiens (Human) acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] acrosomal membrane [GO:0002080]; membrane [GO:0016020]; sperm plasma membrane [GO:0097524] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509] IILGFLLFLTILK;INPAKGIALITK;LRLLGPGAARPASPAARVSPR;REIHCHPKYGIDPEDTK;VLLSAQR 5 3.1 0.87322 -0.11637 0 0 0 0 9.44882 0 0 10.4474 0 10.2944 6.75114 0 Q9NTG7 SIR3_HUMAN "NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)" SIRT3 SIR2L3 Homo sapiens (Human) aerobic respiration [GO:0009060]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of catalase activity [GO:1902553]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of superoxide dismutase activity [GO:1901671]; protein deacetylation [GO:0006476] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "enzyme binding [GO:0019899]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" GKLSLQDVAELIRAR 1 3.8 0.85771 -0.081203 7.40659 0 0 0 0 0 0 0 0 0 0 0 Q9NTI2 AT8A2_HUMAN Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2) ATP8A2 ATPIB Homo sapiens (Human) aminophospholipid translocation [GO:0140331]; axonogenesis [GO:0007409]; detection of light stimulus involved in visual perception [GO:0050908]; determination of adult lifespan [GO:0008340]; eating behavior [GO:0042755]; inner ear morphogenesis [GO:0042472]; involuntary skeletal muscle contraction [GO:0003011]; negative regulation of cell population proliferation [GO:0008285]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling posture [GO:0050884]; neuron development [GO:0048666]; phospholipid translocation [GO:0045332]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; response to auditory stimulus [GO:0010996]; retina layer formation [GO:0010842]; skin development [GO:0043588] cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] ENDVALIIDGHTLK;LMQNSTK;NGMWHTIMWK;SSVGPVR 4 3.2 0.96035 -1.0549 0 0 0 0 0 0 11.909 0 0 0 9.34556 10.0856 Q9NTI5 PDS5B_HUMAN Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) PDS5B APRIN AS3 KIAA0979 Homo sapiens (Human) cell division [GO:0051301]; cell population proliferation [GO:0008283]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677] DIFMFITR;ERRAHAR;FNDIHVPIR;GKRGRPPKPLGGGTPK;GRPSKTPSPSQPK;LPLEYMAICALCAKDPVK;NYLPPEMKSFFTPGKPK;TFMDMDQDSEEEK 8 7 0.97955 -1.8451 0 5.0209 10.7689 7.57107 0 0 0 3.78848 0 8.75876 8.32481 12.2522 Q9NTJ3 SMC4_HUMAN Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) SMC4 CAPC SMC4L1 Homo sapiens (Human) cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697] AMQIQEQK;AQQDKLDK;GEKLNRVK;IAEMETQK;ITYERDSFR;LGDLGAIDEK;LIGIYKTYNITK;LMITHIVNQNFK;LTQEETNFK;MVEKEKDALEGEK;SLVHDLFQK;VEEAKSSLAMNRSR;VLDAIIQEK 13 10 0.97814 -7.7155 0 11.1342 11.2614 9.64317 9.53146 0 11.4182 14.255 12.2193 9.5772 12.7428 0 Q9NTJ4 MA2C1_HUMAN Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) MAN2C1 MANA MANA1 Homo sapiens (Human) mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] cytosol [GO:0005829]; nucleoplasm [GO:0005654] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] AQQLEWVKSR;LDPTGRLTSLVLVASGR;MCSEFWLPDTFGYSAQLPQIMHGCGIRR 3 5.8 0.97504 -2.3796 0 6.60626 0 0 0 0 10.3327 0 0 4.79649 0 0 Q9NTK5 OLA1_HUMAN Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9) OLA1 GTPBP9 PRO2455 PTD004 Homo sapiens (Human) ATP metabolic process [GO:0046034] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; platelet alpha granule lumen [GO:0031093] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023] FNTPQQPK;IGIVGLPNVGK;SWVIDQK;VPVPDER 4 8.3 0.92769 -0.45843 11.0813 0 10.9676 7.81986 7.81134 0 0 0 0 12.1735 11.7578 9.97613 Q9NTM9 CUTC_HUMAN Copper homeostasis protein cutC homolog CUTC CGI-32 Homo sapiens (Human) copper ion homeostasis [GO:0055070]; copper ion transport [GO:0006825]; protein tetramerization [GO:0051262] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] copper ion binding [GO:0005507] TLNAIAK 1 2.6 0.91543 -0.33449 0 0 0 0 0 0 0 0 0 9.99972 0 0 Q9NTN9 SEM4G_HUMAN Semaphorin-4G SEMA4G KIAA1619 Homo sapiens (Human) axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] SQGSRTALIQDIERGNR 1 2.4 0.75998 0.070187 0 0 0 7.58571 0 0 0 0 0 0 0 0 Q9NTW7 ZF64B_HUMAN Zinc finger protein 64 (Zfp-64) (Zinc finger protein 338) ZFP64 ZNF338 Homo sapiens (Human) mesenchymal cell differentiation [GO:0048762]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CEFCDVRCTMK;DNLTMHMRCHTSVKPHK;KHLRIHSDERPYK 3 6.4 0.97584 -2.3296 0 0 0 0 0 8.25706 0 0 5.53978 0 0 0 Q9NTW7 ZF64B_HUMAN Zinc finger protein 64 (Zfp-64) (Zinc finger protein 338) ZFP64 ZNF338 Homo sapiens (Human) mesenchymal cell differentiation [GO:0048762]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CNYCSFDTK 1 1.4 0.79665 0.015103 0 0 0 0 4.98555 0 0 0 0 8.01814 0 0 Q9NTX5 ECHD1_HUMAN Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) ECHDC1 Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635] cytosol [GO:0005829] carboxy-lyase activity [GO:0016831]; methyl/ethyl malonyl-CoA decarboxylase activity [GO:0004492] MAKSLLKTASLSGR;NTFSSGSDLNAVK;SLEEAQEWLK;SLGLQRR 4 15.5 0.96551 -1.1469 10.4833 0 0 0 6.69 0 0 8.26903 0 0 0 0 Q9NTX9 F217B_HUMAN Protein FAM217B FAM217B C20orf177 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] ARPPTAPGTSGALKSPGRSK;VETSGHIRVPK;VGGLLGK 3 9.9 0.98065 -1.7949 0 0 0 0 0 0 0 0 0 12.4437 0 9.12936 Q9NU02 ANKE1_HUMAN Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) ANKEF1 ANKRD5 Homo sapiens (Human) calcium ion binding [GO:0005509] LDNLPKPAENQK;YLNKSFVLGSYGPK 2 3.4 0.9176 -0.40095 0 0 0 10.6375 0 0 10.2432 11.1273 0 0 0 0 Q9NU19 TB22B_HUMAN TBC1 domain family member 22B TBC1D22B C6orf197 Homo sapiens (Human) Golgi apparatus [GO:0005794] 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096] IDEQVHNHFR;ILFIWAIR;ISDQNASGAPPMTVREK 3 6.9 0.89633 -0.24948 0 0 0 9.96389 0 10.0094 0 0 0 0 9.36403 0 Q9NU22 MDN1_HUMAN Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055] "cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CSLPPSYCSK;DGKDSETGLLIK;DVFGSNSNPYMGTRLFR;EEAEADDGGQGEDK;ELKEFVK;ELNEVLQSR;GGEFAWR;HILMQKQRALSDLFK;IFNSDELIHFRLR;KMVAFNNQIDHEVTVEK;KQDHLWQQSTTR;LAEPTEK;LDERLWGDDDEEEDEEEEDNK;LEAVLLLMQR;LLIERATNQDWMLRVK;LTEYQKNELK;LVQALLEKHVSSLR;LWGDDDEEEDEEEEDNK;SVQLWPAMEYLAMLWRYK;TLFKFMKK;VRKQEEIDVIQEVLEK;YWTKIHLDNLDKR 22 4.8 0.97848 -7.4381 11.3325 11.0815 12.5468 9.8813 11.6711 12.6929 0 10.1246 12.7965 9.78359 0 0 Q9NU23 LYRM2_HUMAN LYR motif-containing protein 2 LYRM2 Homo sapiens (Human) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrion [GO:0005739] AASRLPPATLTLKQFVR;LPPATLTLKQFVR 2 19.3 0.71166 0.15513 0 0 0 6.39876 0 0 0 0 0 7.22709 0 0 Q9NU39 FX4L1_HUMAN Forkhead box protein D4-like 1 (FOXD4-like 1) FOXD4L1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DSDGEDGKIDVLGEEEDEDEVEDEEEEASQK;EPGHPGK 2 9.3 0.92759 -0.45692 0 10.5501 0 0 0 0 0 0 0 0 0 0 Q9NU53 GINM1_HUMAN Glycoprotein integral membrane protein 1 GINM1 C6orf72 UNQ710/PRO1361 Homo sapiens (Human) membrane [GO:0016020] INVTTLK 1 2.1 0.91121 -0.32407 0 11.6738 0 0 0 0 0 0 0 0 0 0 Q9NU63 ZFP57_HUMAN Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698) ZFP57 C6orf40 ZNF698 Homo sapiens (Human) autosome genomic imprinting [GO:0141068]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IHQNQEPVDGNQECTLR;LVRHQQTHWKQK;MFEQLKPIEPR;SFSSFSRLVR;TQAPITGTLCQDAR;TYCDASGLSRHRR 6 14.3 0.96124 -1.0605 8.40523 5.50363 0 0 0 0 0 11.439 10.7804 0 10.398 0 Q9NUA8 ZBT40_HUMAN Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) bone mineralization [GO:0030282]; DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EILSIPSETASPEASLR;FHECDQCK;YHENLSEIFTDNQILLK 3 3.4 0.76561 0.062941 0 0 0 6.14447 0 0 0 0 0 6.28207 7.20799 0 Q9NUB1 ACS2L_HUMAN "Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)" ACSS1 ACAS2L KIAA1846 Homo sapiens (Human) acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol catabolic process [GO:0006068]; propionate biosynthetic process [GO:0019542] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218] ELLETTCR;IAKYAVPDEILVVKR;LANTLKRHGVHR;TIYGDHQR 4 6.2 0.97763 -1.9531 0 0 9.11772 0 0 7.01502 7.50589 0 0 0 0 9.13301 Q9NUC0 SRTD4_HUMAN SERTA domain-containing protein 4 SERTAD4 Homo sapiens (Human) nucleus [GO:0005634] AHILYMSLEKLK;GAGPPLAGSHYR 2 6.7 0.95156 -0.69053 0 0 0 0 0 3.75958 0 0 0 10.856 0 0 Q9NUD5 ZCHC3_HUMAN Zinc finger CCHC domain-containing protein 3 ZCCHC3 C20orf99 Homo sapiens (Human) activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481] cytoplasm [GO:0005737] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GEEADGGR;KGAAEAGR 2 4 0.90619 -0.2723 0 0 0 9.52859 8.91004 0 0 0 0 9.83066 0 0 Q9NUG4 CCM2L_HUMAN Cerebral cavernous malformations 2 protein-like (CCM2-like) CCM2L C20orf160 Homo sapiens (Human) heart morphogenesis [GO:0003007] CCCGSTGWGCPSR;CLLLTWR 2 4.6 0.81023 0.0097756 0 0 0 0 0 0 0 0 0 0 0 5.47518 Q9NUG4 CCM2L_HUMAN Cerebral cavernous malformations 2 protein-like (CCM2-like) CCM2L C20orf160 Homo sapiens (Human) heart morphogenesis [GO:0003007] CLLLTWR;HTICSLDWRMGWGGGAAEAPTR 2 12.3 0.9542 -0.95456 0 0 11.3093 0 0 0 0 9.2436 0 0 0 0 Q9NUG6 PDRG1_HUMAN p53 and DNA damage-regulated protein 1 PDRG1 C20orf126 PDRG Homo sapiens (Human) protein folding [GO:0006457]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] unfolded protein binding [GO:0051082] MLSPEAERVLR 1 8.3 0.92198 -0.44534 0 0 0 0 0 0 0 0 0 7.82318 0 0 Q9NUI1 DECR2_HUMAN "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (pDCR) (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)" DECR2 PDCR SDR17C1 Homo sapiens (Human) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; unsaturated fatty acid biosynthetic process [GO:0006636] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] "2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]" APPAVMAAVDQALKEFGR;IAEIFMRHGCHTVIASRSLPR 2 13.4 0.52809 0.18665 0 0 0 6.32851 6.44223 5.89251 0 0 0 0 0 0 Q9NUJ1 ABHDA_HUMAN "Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondrial) (EC 3.1.1.93)" ABHD10 Homo sapiens (Human) acyl deglucuronidation [GO:0036235]; cellular glucuronidation [GO:0052695]; protein depalmitoylation [GO:0002084] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mycophenolic acid acyl-glucuronide esterase activity [GO:0102390]; palmitoyl-(protein) hydrolase activity [GO:0008474]" GLSVLLARIPQRAPR;LLHGMKDDIVPWHTSMQVADR 2 11.8 0.97985 -1.8709 0 0 0 0 0 0 0 0 0 0 0 9.77264 Q9NUK0 MBNL3_HUMAN Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) MBNL3 CHCR MBLX39 MBXL Homo sapiens (Human) mRNA processing [GO:0006397]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA binding [GO:0003723] NNLIQQK;VCHVENGRVVACFDSLKGR 2 7.3 0.84985 -0.078268 0 0 0 0 0 8.41612 0 0 0 0 0 9.29941 Q9NUL3 STAU2_HUMAN Double-stranded RNA-binding protein Staufen homolog 2 STAU2 Homo sapiens (Human) anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; eye morphogenesis [GO:0048592]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489] axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; kinesin binding [GO:0019894]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] LAQIQQAK;RAATTVLQELKK;SPQNGESGKDVDDDK 3 6.1 0.9788 -1.972 0 0 0 0 8.00843 9.18876 0 0 0 0 0 0 Q9NUL5 SHFL_HUMAN Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) SHFL C19orf66 FLJ11286 IRAV RYDEN SFL Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] EEEEEEEEVEDEEGGPRE;EVSRCRK;MWGLAEFHCPKCRHNFR;WDRDPDR 4 16.8 0.97577 -3.4309 9.45609 0 0 0 0 0 0 4.41657 0 10.6171 9.22226 0 Q9NUL7 DDX28_HUMAN Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) DDX28 MDDX28 Homo sapiens (Human) mitochondrial large ribosomal subunit assembly [GO:1902775] cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843] ALTRPVRLFSLVTRLLLAPR;EPLPQAT;GLVLVPSR;NLPRPVLVRPGPLLVSAR;TLSYLLPLLQR 5 11.9 0.95589 -0.87037 0 0 0 8.20065 0 0 7.94509 0 0 6.11651 0 9.12709 Q9NUM4 T106B_HUMAN Transmembrane protein 106B TMEM106B Homo sapiens (Human) dendrite morphogenesis [GO:0048813]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; lysosomal transport [GO:0007041]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; neuron cellular homeostasis [GO:0070050]; positive regulation of dendrite development [GO:1900006]; regulation of lysosome organization [GO:1905671] endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] ATPase binding [GO:0051117] NGLVNSEVHNEDGR 1 5.1 0.7846 0.023794 0 10.0441 0 0 0 0 0 0 0 0 0 0 Q9NUP1 BL1S4_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) BLOC1S4 CNO Homo sapiens (Human) anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; platelet aggregation [GO:0070527] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829] LEAFVRMVGGR;VARMEEQVTK 2 9.7 0.98164 -1.7689 8.85293 0 0 0 7.87787 7.9292 11.9196 0 0 0 0 0 Q9NUP7 TRM13_HUMAN tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) TRMT13 CCDC76 Homo sapiens (Human) tRNA methylation [GO:0030488] metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050]; tRNA methyltransferase activity [GO:0008175] ILCPLDPK 1 1.7 0.91747 -0.42856 0 0 0 0 0 0 0 11.7397 0 0 10.907 0 Q9NUP9 LIN7C_HUMAN Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) LIN7C MALS3 VELI3 Homo sapiens (Human) exocytosis [GO:0006887]; morphogenesis of an epithelial sheet [GO:0002011]; neurotransmitter secretion [GO:0007269]; protein transport [GO:0015031]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; synaptic vesicle transport [GO:0048489] basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202] cytoskeletal protein binding [GO:0008092]; L27 domain binding [GO:0097016]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674] AIELLEKLQRSGEVPPQK;GDQLLSVNGVSVEGEHHEK 2 18.8 0.78234 0.025632 0 0 0 0 0 0 8.47086 8.40854 0 0 0 13.4349 Q9NUQ2 PLCE_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) AGPAT5 Homo sapiens (Human) acylglycerol metabolic process [GO:0006639]; CDP-diacylglycerol biosynthetic process [GO:0016024]; hematopoietic progenitor cell differentiation [GO:0002244]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746] GLAVLKHVLTPRIK;KLYVNTWIYGTLLGCLWVTIK;NYLDAIYDVTVVYEGKDDGGQR 3 15.7 0.8899 -0.20646 0 0 0 0 0 0 8.60452 0 4.92305 8.76789 4.80338 0 Q9NUQ6 SPS2L_HUMAN SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) SPATS2L DNAPTP6 SP1224 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] RNA binding [GO:0003723] AEIKHFVSER;HFVSERKYDEELGK;ISILEEPSK;LLSGTLLWIPR 4 6.5 0.93814 -0.57512 0 6.36427 0 0 0 0 0 10.6439 9.63566 0 0 0 Q9NUQ7 UFSP2_HUMAN Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) UFSP2 C4orf20 Homo sapiens (Human) negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of type II interferon production [GO:0032649]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] deUFMylase activity [GO:0071567] NILRFIQFEPEEDIK 1 3.2 0.94494 -0.64508 0 0 0 0 0 0 0 11.7069 0 0 0 0 Q9NUQ8 ABCF3_HUMAN ATP-binding cassette sub-family F member 3 ABCF3 Homo sapiens (Human) defense response to virus [GO:0051607] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296] LLNQQREYEAQQQYR;LVCRELWVCEGGGVTR;YGLVGRNGLGK 3 5.9 0.98077 -1.7428 8.32269 0 0 0 0 0 0 8.8568 0 0 0 0 Q9NUQ9 CYRIB_HUMAN CYFIP-related Rac1 interactor B (L1) CYRIB CYRI FAM49B BM-009 Homo sapiens (Human) cellular response to molecule of bacterial origin [GO:0071219]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitochondrial fission [GO:0090140] cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093] "MHC class Ib protein binding, via antigen binding groove [GO:0023030]; small GTPase binding [GO:0031267]" EAIQHPADEK;EAIQHPADEKLQEK;VMLETPEYR 3 7.1 0.93712 -0.52656 0 12.291 0 0 0 0 0 10.7823 0 0 0 0 Q9NUS5 AP5S1_HUMAN AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5) AP5S1 C20orf29 Homo sapiens (Human) double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] LLLDHLRLLAPSTSLLLR 1 9 0.92057 -0.44393 0 0 0 0 0 0 0 0 0 0 4.61924 0 Q9NUT2 MITOS_HUMAN "Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)" ABCB8 MABC1 MITOSUR Homo sapiens (Human) cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; membrane [GO:0016020]; mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AEGEYSDGYR;GGPFPGR;IVALVGQSGGGK;TLDPSWLR;TVRAFAMEQR;VGIRGGPFPGRLLPPLR 6 7.8 0.97256 -2.5997 0 0 8.94161 9.58402 0 0 8.1166 0 0 0 8.53768 0 Q9NUT2 MITOS_HUMAN "Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)" ABCB8 MABC1 MITOSUR Homo sapiens (Human) cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; membrane [GO:0016020]; mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] IVALVGQSGGGK;RVKLLLPAAPVLPR;TLDPSWLR;TVRAFAMEQR 4 7 0.76722 0.059642 0 1.69461 4.24747 0 0 0 0 0 0 0 4.57162 0 Q9NUU7 DD19A_HUMAN ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) DDX19A DDX19L Homo sapiens (Human) poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of apoptotic process [GO:0043065]; response to zinc ion [GO:0010043] cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] DPNSPLYSVK;EGKEKVLVTTNVCAR;GLAVNMVDSK;IQEHFNK;KTASWLAAELSKEGHQVALLSGEMMVEQR;VVPDPNVIK 6 16.7 0.98056 -1.6094 0 0 0 0 0 0 0 0 13.3411 10.3424 9.60765 0 Q9NUV9 GIMA4_HUMAN GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] GTP binding [GO:0005525] KLAEQEAHYAVR;KVFHSGTAAK;VELEREKAR;YCALNNK 4 11.6 0.97565 -2.3308 0 0 0 0 0 0 0 0 11.5849 8.0415 0 10.6688 Q9NUW8 TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 Homo sapiens (Human) DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; exonuclease activity [GO:0004527]; single-stranded DNA binding [GO:0003697] DISAPNDGTAQR 1 2 0.80908 0.0090783 0 0 0 0 0 0 0 0 0 6.4852 0 0 Q9NUW8 TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 Homo sapiens (Human) DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; exonuclease activity [GO:0004527]; single-stranded DNA binding [GO:0003697] LRLTSMPRPSLTRTSLSAR 1 5.1 0.86008 -0.082572 0 0 0 0 0 0 9.60327 0 0 0 0 0 Q9NUX5 POTE1_HUMAN Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein) POT1 Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; establishment of protein localization to telomere [GO:0070200]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA strand elongation [GO:0060383]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of telomere maintenance via telomerase [GO:0032210]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]" 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; DEAD/H-box RNA helicase binding [GO:0017151]; G-rich single-stranded DNA binding [GO:1990955]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded telomeric DNA binding [GO:0043047]; telomerase inhibitor activity [GO:0010521]; telomeric D-loop binding [GO:0061821]; telomeric DNA binding [GO:0042162] LRSYKPRR 1 1.3 0.97767 -1.5135 12.0166 0 0 0 11.1527 11.2434 0 0 0 0 0 0 Q9NUZ1 ACOXL_HUMAN Acyl-coenzyme A oxidase-like protein (Acyl-CoA oxidase-like protein) (EC 1.3.3.-) ACOXL Homo sapiens (Human) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660] ECTGGMGYMMENR;LAVAFQAMGAMK;QFGPKTK;SQGPHCFIVPVR 4 8 0.80971 0.0096936 0 0 0 0 0 0 0 5.33056 0 0 0 0 Q9NUZ1 ACOXL_HUMAN Acyl-coenzyme A oxidase-like protein (Acyl-CoA oxidase-like protein) (EC 1.3.3.-) ACOXL Homo sapiens (Human) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660] IRNQLLDLCDSVK;LAVAFQAMGAMK;QFGPKTK;SQGPHCFIVPVR 4 7.6 0.97213 -2.7969 0 0 0 0 10.6007 9.01304 0 0 0 0 0 0 Q9NV06 DCA13_HUMAN DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) DCAF13 WDSOF1 HSPC064 Homo sapiens (Human) "decidualization [GO:0046697]; epigenetic programming in the zygotic pronuclei [GO:0044725]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; oocyte growth [GO:0001555]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; rRNA processing [GO:0006364]; spindle assembly involved in female meiosis [GO:0007056]" cell junction [GO:0030054]; centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AAKDYNQK;FQHYPHIK;SIYSQIQEQRIMK 3 6.5 0.9759 -2.3296 0 0 0 0 0 9.09093 12.4549 0 0 0 0 0 Q9NV29 TM100_HUMAN Transmembrane protein 100 TMEM100 Homo sapiens (Human) angiogenesis [GO:0001525]; arterial endothelial cell differentiation [GO:0060842]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; in utero embryonic development [GO:0001701]; Notch signaling pathway [GO:0007219]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vasculogenesis [GO:2001214]; regulation of calcium-mediated signaling [GO:0050848]; regulation of sensory perception of pain [GO:0051930]; vasculogenesis [GO:0001570] endoplasmic reticulum [GO:0005783]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] EILGAPK 1 5.2 0.90859 -0.30943 0 0 0 0 0 0 0 0 7.98259 0 0 0 Q9NV56 MRGBP_HUMAN MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) MRGBP C20orf20 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786] VLTANSNPSSPSAAKRR 1 8.3 0.85039 -0.075028 0 0 0 0 0 0 9.60177 0 0 0 0 0 Q9NV58 RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) RNF19A RNF19 Homo sapiens (Human) "microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] MNDGSCNHMTCAVCGCEFCWLCMK;QMGSDRDLQSSASSVSLPSVKK 2 5.5 0.54819 0.18354 0 0 0 0 0 0 0 0 0 0 0 7.73261 Q9NV64 TM39A_HUMAN Transmembrane protein 39A TMEM39A SUSR2 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of viral genome replication [GO:0045070] endoplasmic reticulum membrane [GO:0005789] CLYRAMGPYNVAVPSDVSHAR;NEVECLKADFNHR 2 7 0.92877 -0.4628 0 0 0 0 0 0 0 0 0 5.52052 0 1.91926 Q9NV66 TYW1_HUMAN S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein) TYW1 RSAFD1 Homo sapiens (Human) wybutosine biosynthetic process [GO:0031591] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]" NEDGERRAMITPALR;SCGGHCK;TQGKNLQEKSVPK 3 4.8 0.97773 -1.5213 0 0 0 0 0 8.83545 0 0 0 0 0 0 Q9NV70 EXOC1_HUMAN Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) defense response to virus [GO:0051607]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" CISNQIRQMEEVKISK;EVDQIELK;ISCLEAEK;VANESQK 4 4.4 0.97578 -2.3068 0 0 0 0 8.51132 0 0 0 10.3523 0 0 0 Q9NV72 ZN701_HUMAN Zinc finger protein 701 ZNF701 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIHTGEKPYK;DLVREEKTR;IGNQVEK;KLMSSTER;SNLERHHRLHTGK;TLYRDVMLENYR;VIHTGEK 7 13.7 0.97817 -1.5098 10.4768 0 0 10.0428 10.7519 0 10.9631 0 0 3.83855 0 0 Q9NV79 PCMD2_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 PCMTD2 C20orf36 Homo sapiens (Human) protein modification process [GO:0036211] cytoplasm [GO:0005737] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] ADYYLEEFKENAYK;EHEEYMKNLLK;LVQLPPVAVRSLQDLARIAIR;RMETIVFLDKEVFASR 4 17.2 0.98095 -1.5757 9.67301 0 0 0 12.7405 0 0 0 0 6.71493 0 9.91843 Q9NV88 INT9_HUMAN Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74) INTS9 RC74 Homo sapiens (Human) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LSNLPGWSLKDGNAFLDK;QPCVVFTGHPSLR 2 4.7 0.89958 -0.25847 0 0 0 8.35878 7.66945 0 0 0 0 0 0 0 Q9NV96 CC50A_HUMAN Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) TMEM30A C6orf67 CDC50A Homo sapiens (Human) aminophospholipid transport [GO:0015917]; phospholipid translocation [GO:0045332]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endosome [GO:0036010]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; transport vesicle membrane [GO:0030658] aminophospholipid flippase activity [GO:0015247]; structural molecule activity [GO:0005198] NSSNTADITI;SFEGNVFMYYGLSNFYQNHR 2 8.3 0.9287 -0.46324 0 0 0 0 0 0 0 8.56544 0 0 0 0 Q9NVA2 SEP11_HUMAN Septin-11 SEPTIN11 SEPT11 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; regulation of synapse organization [GO:0050807] axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; postsynaptic specialization of symmetric synapse [GO:0099629]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ARQYPWGVVQVENENHCDFVK;ELHEKFDLLK;FDLLKRTHQEEK;KLDSKVNIIPIIAK 4 12.1 0.98102 -1.624 0 0 0 0 8.80938 0 0 0 0 0 0 0 Q9NVC3 S38A7_HUMAN Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) SLC38A7 SNAT7 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; glutamine transport [GO:0006868]; sodium ion transport [GO:0006814] axon [GO:0030424]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuronal cell body [GO:0043025] L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine:sodium symporter activity [GO:0140901]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine:sodium symporter activity [GO:0140902] IIAVMAK;KFTISLTAFLFILPLSIPR;RVLQTLVWFLLTLLLALFIPDIGK;VLQTLVWFLLTLLLALFIPDIGK 4 10.8 0.014 0.81962 0 0 0 0 0 7.53458 9.04475 0 0 11.1471 0 3.76394 Q9NVC6 MED17_HUMAN Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] AAATIDSLASR;EIFAQLSR;LSGPQAFDK;SVTENQENK 4 5.7 0.97578 -2.3304 0 0 0 0 0 0 0 0 0 9.83879 0 0 Q9NVD3 SETD4_HUMAN SET domain-containing protein 4 (EC 2.1.1.-) (EC 2.1.1.364) SETD4 C21orf18 C21orf27 Homo sapiens (Human) chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; methylation [GO:0032259]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell proliferation in bone marrow [GO:0071863] cytosol [GO:0005829]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; transcription coactivator activity [GO:0003713] AEEQRAHVQEFFASSR 1 3.6 0.91665 -0.42575 0 0 0 0 0 0 11.5334 11.8387 0 0 0 0 Q9NVD7 PARVA_HUMAN Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) PARVA MXRA2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin-mediated cell contraction [GO:0070252]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; heterotypic cell-cell adhesion [GO:0034113]; outflow tract septum morphogenesis [GO:0003148]; protein stabilization [GO:0050821]; smooth muscle cell chemotaxis [GO:0071670]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin binding [GO:0003779]; cadherin binding [GO:0045296]; protein kinase inhibitor activity [GO:0004860] LFEKLESEKLNVAEVTQSEIAQK 1 6.2 0.59663 0.17852 0 0 0 0 0 0 0 0 9.81197 0 0 0 Q9NVE4 CCD87_HUMAN Coiled-coil domain-containing protein 87 CCDC87 Homo sapiens (Human) cell differentiation [GO:0030154]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] ELKSIPR;GRPYLDKMKSDK;LRLIKVILDELK;SDKVEMLYWLQQQR;VEMLYWLQQQRRVR 5 5.3 0.97407 -1.4021 0 0 10.7884 13.9106 13.8587 0 0 10.3933 0 0 0 0 Q9NVE5 UBP40_HUMAN Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) USP40 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] IGISWNKK;QEDFLDLTVAVK 2 1.6 0.9367 -0.55585 7.7811 7.64118 11.5498 0 0 0 12.7985 12.9549 8.06776 11.3483 5.89891 12.1841 Q9NVE7 PANK4_HUMAN 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) PANK4 Homo sapiens (Human) coenzyme A biosynthetic process [GO:0015937]; pantothenate metabolic process [GO:0015939] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791] AVASQPDSVDAAER;LLLVQTGSSSPCLDLSR;QKYWNKLQTLR 3 5.4 0.97844 -2.0896 0 0 0 0 0 0 0 10.7479 0 0 0 0 Q9NVF7 FBX28_HUMAN F-box only protein 28 FBXO28 CENP-30 KIAA0483 Homo sapiens (Human) protein polyubiquitination [GO:0000209] kinetochore [GO:0000776] identical protein binding [GO:0042802] VIDEIYR 1 1.9 0.93326 -0.49562 0 0 0 0 0 0 0 0 0 0 10.4831 0 Q9NVF9 EKI2_HUMAN Ethanolamine kinase 2 (EKI 2) (EC 2.7.1.82) (Ethanolamine kinase-like protein) ETNK2 EKI2 HMFT1716 Homo sapiens (Human) in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; phosphatidylethanolamine biosynthetic process [GO:0006646]; placenta development [GO:0001890]; post-embryonic development [GO:0009791] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305] EPRLFSLSADVPK 1 3.8 0.88727 -0.18472 0 0 0 0 0 0 0 0 7.31306 0 0 0 Q9NVH0 EXD2_HUMAN Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2) EXD2 C14orf114 EXDL2 Homo sapiens (Human) DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; nucleic acid metabolic process [GO:0090304]; replication fork processing [GO:0031297] cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310] LICGGKTLPRTLLDILADGTILK;LPKLICGGK;NVIPHEYRK;SGARALLNAESLPTQR;TLLDILADGTILK;YLAMRQR 6 9.3 0.97465 -3.1055 11.139 11.6204 0 0 0 0 9.33996 0 0 0 8.35821 0 Q9NVH1 DJC11_HUMAN DnaJ homolog subfamily C member 11 DNAJC11 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401] EASSEELKAAYRR;VKGSLKAGFFGTVVEYGAER 2 5.9 0.81305 -0.016127 4.8269 0 9.80711 0 0 7.20565 0 0 0 0 0 0 Q9NVH2 INT7_HUMAN Integrator complex subunit 7 (Int7) INTS7 C1orf73 Homo sapiens (Human) cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] chromosome [GO:0005694]; cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] KYTPVSYMRYFFQK;LCVLKVTQQSEKHLEK;YTPVSYMRYFFQK 3 3.2 0.97304 -2.5157 0 0 8.06577 0 0 10.098 0 0 0 0 9.05891 0 Q9NVH6 TMLH_HUMAN "Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (Epsilon-trimethyllysine hydroxylase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)" TMLHE TMLH Homo sapiens (Human) carnitine biosynthetic process [GO:0045329]; negative regulation of oxidoreductase activity [GO:0051354] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] iron ion binding [GO:0005506]; trimethyllysine dioxygenase activity [GO:0050353] AVINTVPYDVVHR;QLCGCYLTRDDVLNTAR;TIRLDETTLFFTWPDGHVTK;YANTVMRFDYVWLR 4 15.2 0.89259 -0.22436 0 12.7935 0 10.854 0 10.1708 0 10.2696 0 13.0805 13.366 11.6261 Q9NVH6 TMLH_HUMAN "Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (Epsilon-trimethyllysine hydroxylase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)" TMLHE TMLH Homo sapiens (Human) carnitine biosynthetic process [GO:0045329]; negative regulation of oxidoreductase activity [GO:0051354] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] iron ion binding [GO:0005506]; trimethyllysine dioxygenase activity [GO:0050353] EIKLYIVCR;TIRLDETTLFFTWPDGHVTK;YANTVMRFDYVWLR 3 10.8 0.90257 -0.26291 0 0 0 0 0 0 9.06434 0 0 0 0 0 Q9NVI1 FANCI_HUMAN Fanconi anemia group I protein (Protein FACI) FANCI KIAA1794 Homo sapiens (Human) interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182] LSDILNEK;MDQKILSLAAEKTADK;MNLQEIPPLVYQLLVLSSK;NMEKLVK;QLINTLCSGRWDQQYVIQLTSMFK;SISLLCLEGLQKIFSAVQQFYQPKIQQFLR 6 7.8 0.94673 -0.66126 0 0 7.08545 0 9.55919 6.38272 0 0 11.0694 0 0 10.8097 Q9NVI7 ATD3A_HUMAN ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) ATAD3A Homo sapiens (Human) antiviral innate immune response [GO:0140374]; DNA damage response [GO:0006974]; HRI-mediated signaling [GO:0140468]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; regulation of cell growth [GO:0001558] mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein serine/threonine kinase inhibitor activity [GO:0030291] AAEHRQTVLESIR;ETSRITVLEALR;LFDWANTSR;LFDWANTSRR;TLSEETR 5 6.6 0.97272 -2.6119 8.53904 0 9.30364 8.22212 0 0 0 0 0 7.96757 0 0 Q9NVJ2 ARL8B_HUMAN ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) ARL8B ARL10C GIE1 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; antigen processing and presentation following phagocytosis [GO:0002747]; antigen processing and presentation of polysaccharide antigen via MHC class II [GO:0002505]; autophagosome-lysosome fusion [GO:0061909]; calcium ion regulated lysosome exocytosis [GO:1990927]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; early endosome to Golgi transport [GO:0034498]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; protein localization to early endosome [GO:1902946]; protein transport [GO:0015031]; viral exocytosis [GO:0046754] axon cytoplasm [GO:1904115]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; synapse [GO:0045202] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DLPNALDEKQLIEK 1 7.5 0.91804 -0.43536 0 0 10.2183 0 0 0 0 0 0 0 0 0 Q9NVK5 FGOP2_HUMAN FGFR1 oncogene partner 2 FGFR1OP2 HSPC123 Homo sapiens (Human) response to wounding [GO:0009611]; wound healing [GO:0042060] cytosol [GO:0005829] identical protein binding [GO:0042802] EQHSKIDMVHRNK;GLREILQITRESFLNLR 2 11.9 0.97583 -1.4541 0 0 0 0 0 0 0 0 0 0 0 7.53286 Q9NVL1 F86C1_HUMAN Putative protein FAM86C1P (EC 2.1.1.-) (Protein FAM86C) FAM86C1P FAM86C FAM86C1 Homo sapiens (Human) methylation [GO:0032259] protein-containing complex [GO:0032991] methyltransferase activity [GO:0008168] WQSLEAK 1 4.2 0.91606 -0.36586 0 0 0 0 0 0 0 0 0 0 0 10.0999 Q9NVL8 FAME_HUMAN Factor associated with metabolism and energy (Protein CCDC198) CCDC198 C14orf105 FAME Homo sapiens (Human) energy homeostasis [GO:0097009] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] KMQTPMYTSENRQYLHK 1 5.7 0.48576 0.18987 0 0 8.76957 0 0 0 0 0 0 0 0 0 Q9NVM6 DJC17_HUMAN DnaJ homolog subfamily C member 17 DNAJC17 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; spliceosomal complex disassembly [GO:0000390] cytoplasm [GO:0005737]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] AENTEGQGTPK;ALSCHPDK 2 6.2 0.94432 -0.62609 0 0 9.22841 0 6.19757 0 0 0 0 0 0 0 Q9NVM9 INT13_HUMAN Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95) INTS13 ASUN C12orf11 GCT1 Homo sapiens (Human) cell division [GO:0051301]; centrosome localization [GO:0051642]; flagellated sperm motility [GO:0030317]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EDKEDKSEK;IDGSLEVPLER;IDGSLEVPLERAK;TLLMENAERVGNRGR 4 5.2 0.97764 -1.4997 9.6965 0 0 0 0 0 0 0 0 11.6091 10.5673 0 Q9NVN8 GNL3L_HUMAN Guanine nucleotide-binding protein-like 3-like protein GNL3L Homo sapiens (Human) "negative regulation of protein binding [GO:0032091]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of protein stability [GO:0031647]; ribosome biogenesis [GO:0042254]" cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697] GTP binding [GO:0005525]; RNA binding [GO:0003723] AVLADWVSGK;IADAIENK;LVLVLNKIDLVPKEVVEK 3 6.2 0.95189 -0.70086 0 0 0 0 0 0 0 5.57119 0 11.4657 0 3.90612 Q9NVP1 DDX18_HUMAN ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) DDX18 cPERP-D Homo sapiens (Human) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GLDIPEVDWIVQYDPPDDPKEYIHR;KMVNDAEPDTKK;VTKSPQK 3 6.6 0.97946 -1.8988 9.32791 0 0 0 0 0 11.9445 0 0 0 10.9511 0 Q9NVP4 DZAN1_HUMAN Double zinc ribbon and ankyrin repeat-containing protein 1 DZANK1 C20orf12 C20orf84 Homo sapiens (Human) eye photoreceptor cell development [GO:0042462] cell projection [GO:0042995]; centrosome [GO:0005813]; cytoplasm [GO:0005737] metal ion binding [GO:0046872] AIAVSKDCR;EQLIPENR;KEQLIPENRLLLK;VICRACGTGNPAHLR 4 4.9 0.97306 -2.5262 0 0 0 8.59947 0 0 0 11.4321 0 10.625 0 0 Q9NVR0 KLH11_HUMAN Kelch-like protein 11 KLHL11 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVANNEVCVK;WVQRNAEERER 2 3 0.75287 0.076353 0 3.50894 0 0 0 6.33725 0 0 0 0 0 0 Q9NVR2 INT10_HUMAN Integrator complex subunit 10 (Int10) INTS10 C8orf35 Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180] integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EDFRLAMERQVSR;KLFVCDVLPLIINNHDVR;LRAFTDNRDDMALGHVIVLLQQEWPR;VQCEMLLK 4 9.2 0.9639 -1.186 0 0 0 0 8.81551 8.41071 0 0 0 13.469 0 0 Q9NVR5 KTU_HUMAN "Protein kintoun (Dynein assembly factor 2, axonemal)" DNAAF2 C14orf104 KTU Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; in utero embryonic development [GO:0001701]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]; protein stabilization [GO:0050821]; response to retinoic acid [GO:0032526] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; protein folding chaperone complex [GO:0101031] GKAQFNKAR;RQLVVTLPVVLPAARR;TLKAKYK 3 3.8 0.96385 -1.1817 0 0 0 0 0 5.5505 0 7.86901 0 0 0 0 Q9NVR7 TBCC1_HUMAN TBCC domain-containing protein 1 TBCCD1 Homo sapiens (Human) maintenance of centrosome location [GO:0051661]; maintenance of Golgi location [GO:0051684]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; spindle pole centrosome [GO:0031616] ALGQREQK;DLAWLYFEIFDSLSMK;FSLHYLR 3 5.6 0.97562 -2.3232 0 0 0 0 0 8.91193 0 10.125 0 0 0 0 Q9NVS2 RT18A_HUMAN "Large ribosomal subunit protein mL66 (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (39S ribosomal protein S18a, mitochondrial) (MRP-S18-a) (Mrps18a) (S18mt-a) (Large ribosomal subunit protein bS18a)" MRPS18A Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] HSGLLPNHRPR;ITGLCQEEHR;KGPRWNR;MAHRAGRRPWGPR 4 15.2 0.97928 -1.8883 0 0 0 0 0 7.33869 0 0 0 0 7.33423 0 Q9NVS9 PNPO_HUMAN Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) PNPO Homo sapiens (Human) pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829]; mitochondrion [GO:0005739] FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733] KLPEEEAECYFHSRPK 1 6.1 0.87583 -0.12248 0 0 0 9.96852 0 0 0 0 0 0 0 0 Q9NVS9 PNPO_HUMAN Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) PNPO Homo sapiens (Human) pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829]; mitochondrion [GO:0005739] FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733] TLCSHVAAEGLR 1 17.4 0.80355 0.013369 0 0 0 0 0 0 0 0 4.00135 0 0 0 Q9NVT9 ARMC1_HUMAN Armadillo repeat-containing protein 1 ARMC1 ARCP Homo sapiens (Human) intracellular distribution of mitochondria [GO:0048312] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] metal ion binding [GO:0046872] GVISFTFQMAVQRCVVRIR;YLAECRANR 2 9.9 0.95433 -0.90849 5.44814 0 0 0 0 0 0 0 0 0 0 0 Q9NVU0 RPC5_HUMAN DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) POLR3E KIAA1452 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; tRNA transcription by RNA polymerase III [GO:0042797] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] GEQIALNVDGACADETSTYSSK;LCAEDVK;LEKVYNLVK;QFVLTLSELK 4 6.8 0.97876 -2.0551 11.1398 11.4451 0 0 0 0 14.3373 0 0 14.3492 14.3315 0 Q9NVU7 SDA1_HUMAN Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) SDAD1 NUC130 Homo sapiens (Human) protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] FLQPHQREVTK;NNNKLPSNLPQLQNLIKR;QLECCKERFEVK;TLIHLFR;VTKILVAALTFFLGK 5 9.2 0.95539 -0.86075 0 0 0 12.2549 10.0889 0 0 0 0 7.39549 0 6.79559 Q9NVV4 PAPD1_HUMAN "Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)" MTPAP PAPD1 Homo sapiens (Human) histone mRNA catabolic process [GO:0071044]; mitochondrial RNA 3'-end processing [GO:0000965]; mRNA processing [GO:0006397] intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; UTP binding [GO:0002134] FAIETVKNLLESLK;ILNARCPLVR;ISGNFLMEFQVKNVPSER;NVSQSQLQK 4 8.8 0.97987 -1.8779 0 11.3584 8.48325 0 0 0 9.57327 0 0 0 0 0 Q9NVW2 RNF12_HUMAN E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) RLIM RNF12 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] SQTPNNTVTYESERGGFR;WLSENSTCPICR 2 4.8 0.81359 -0.010682 0 0 0 0 7.90394 0 0 0 8.10821 0 0 0 Q9NVX2 NLE1_HUMAN Notchless protein homolog 1 NLE1 HUSSY-07 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; mitotic cell cycle [GO:0000278]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of Notch signaling pathway [GO:0008593]; ribosomal large subunit biogenesis [GO:0042273]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DKCLRIWR 1 1.6 0.87083 -0.095167 8.74896 0 4.989 0 0 0 0 0 0 0 0 0 Q9NVZ3 NECP2_HUMAN Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) NECAP2 Homo sapiens (Human) endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; plasma membrane [GO:0005886] KKEGAAGNPR;LRITAKGQMAYIK 2 8.7 0.96471 -1.2331 0 0 0 0 0 0 0 0 0 0 0 9.12923 Q9NW08 RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) POLR3B Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; snRNA transcription by RNA polymerase III [GO:0042796] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] GSQRIIR;IIVEADRK;LLPAFLKVKGLVK;TPAEFAK;VKDVCEDLVR 5 4 0.97322 -2.4842 0 0 10.875 0 0 0 6.95361 10.925 0 0 0 0 Q9NW13 RBM28_HUMAN RNA-binding protein 28 (RNA-binding motif protein 28) RBM28 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleolus [GO:0005730]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] EITTFEGCKINVTVAK;FELLKHQKLK;FNQLVEQYK;GNKTETR;LCLHNLPKAVDDKQLR;NLSFKCSEDDLK;QCFVVTEK;VMRDLKGVHGNMK;YVRIVLHPDTEHSK 9 13.8 0.9739 -3.0152 0 0 6.94732 0 10.2994 0 11.0924 7.99118 0 10.7295 7.5775 10.0929 Q9NW61 PKHJ1_HUMAN Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x) PLEKHJ1 GNRPX Homo sapiens (Human) "endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] ASYEFMRR;ELQALSR;LVKLVVNFLFYFR 3 18.8 0.96631 -1.2828 0 0 0 0 0 0 0 9.39508 0 0 0 0 Q9NW64 RBM22_HUMAN Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) RBM22 ZC3H16 199G4 Homo sapiens (Human) "cellular response to xenobiotic stimulus [GO:0071466]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007] calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] LDPPEDK 1 1.7 0.9372 -0.53874 0 0 0 0 0 0 0 0 9.76678 0 0 0 Q9NW68 BSDC1_HUMAN BSD domain-containing protein 1 BSDC1 UNQ2494/PRO5781 Homo sapiens (Human) cytoplasm [GO:0005737] LATEGSSGATEK;SWLQQSYQAVKEK 2 5.8 0.96534 -1.2162 0 0 0 0 0 0 0 11.8596 0 0 0 11.9648 Q9NW75 GPTC2_HUMAN G patch domain-containing protein 2 GPATCH2 GPATC2 Homo sapiens (Human) nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] ENHNNNKK;IIRQGPK;QGDDEQSDWFYEK;QPIGAPAAGNSWHFSR 4 8.3 0.9798 -1.878 0 0 0 0 8.55593 0 4.27531 0 0 9.64954 0 0 Q9NW81 DMAC2_HUMAN Distal membrane-arm assembly complex protein 2 (ATP synthase subunit s-like protein) DMAC2 ATP5SL Homo sapiens (Human) mitochondrial respiratory chain complex I assembly [GO:0032981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] mitochondrion [GO:0005739]; SCF ubiquitin ligase complex [GO:0019005] ELQSLSLQR;LGAAVAPEGNQK;SGPEEQPR 3 11.3 0.95273 -0.68239 0 0 0 0 10.0231 0 0 10.8995 0 0 0 0 Q9NW82 WDR70_HUMAN WD repeat-containing protein 70 WDR70 Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] enzyme binding [GO:0019899] ELRRQNEDIEPTSSR;GEFMTCSNDATVR;KARTFDLEAMFEQTR;SLQYSNTGDMILVVSGSSQAK;TDDSNPR 5 10.9 0.95234 -0.77057 9.10324 8.98045 0 0 0 0 11.3833 0 9.46907 0 0 0 Q9NWB6 ARGL1_HUMAN Arginine and glutamate-rich protein 1 ARGLU1 Homo sapiens (Human) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" chromosome [GO:0005694]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; nuclear receptor coactivator activity [GO:0030374]; pre-mRNA binding [GO:0036002] AEFERQR;IILGKGKSRPK;MKLEQER;VEELVAKR 4 12.1 0.97459 -2.3822 0 0 0 0 3.07166 0 0 0 10.0749 0 0 0 Q9NWC5 TM45A_HUMAN Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) TMEM45A DERP7 DNAPTP4 Homo sapiens (Human) membrane [GO:0016020] EQESEEEM 1 2.9 0.74623 0.10231 0 0 3.87175 0 4.93206 0 0 0 0 0 0 0 Q9NWD8 TM248_HUMAN Transmembrane protein 248 TMEM248 C7orf42 Homo sapiens (Human) membrane [GO:0016020] VYHALNPK 1 2.5 0.91588 -0.39033 0 0 0 0 0 0 0 9.39887 0 0 0 0 Q9NWF9 RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) RNF216 TRIAD3 UBCE7IP1 ZIN Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CGAQMCYLCRVSINGYDHFCQHPR;DGQLIECRCCYGEFPFEELTQCADAHLFCK 2 6.2 0.95406 -0.9034 4.92965 0 0 0 0 0 0 0 0 0 0 0 Q9NWH2 TM242_HUMAN Transmembrane protein 242 TMEM242 C6orf35 BM-033 HSPC287 Homo sapiens (Human) mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] LFLVKGGIFLGTVAAAGMLAGFITTLSLAK 1 21.3 0.84175 -0.045328 0 0 0 0 6.82896 0 0 0 0 5.38939 0 0 Q9NWH7 SPAT6_HUMAN Spermatogenesis-associated protein 6 SPATA6 Homo sapiens (Human) cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212] myosin light chain binding [GO:0032027] TPHGRDFDDSLEKCEEYLSPR 1 4.3 0.86009 -0.081735 0 0 0 0 8.79256 0 0 0 0 0 0 0 Q9NWH9 SLTM_HUMAN SAFB-like transcription modulator (Modulator of estrogen-induced transcription) SLTM MET Homo sapiens (Human) apoptotic process [GO:0006915]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] EAERIARER;EVRGERDER;GAPPGNR;GPSSTGASGQAK 4 3.6 0.97224 -2.69 0 0 0 0 0 0 0 0 0 11.1596 0 0 Q9NWK9 BCD1_HUMAN Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) ZNHIT6 BCD1 C1orf181 Homo sapiens (Human) "box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein complex oligomerization [GO:0051259]; snoRNA localization [GO:0048254]" extracellular exosome [GO:0070062]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761] ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; TFIID-class transcription factor complex binding [GO:0001094] GSNNDMKVLHQVKSESTK;LAMSRCETCGTEEAK 2 7 0.9738 -1.3987 0 0 12.0028 10.0705 10.1011 0 0 0 0 6.41817 9.70819 11.9807 Q9NWL6 ASND1_HUMAN Asparagine synthetase domain-containing protein 1 (HCV NS3-transactivated protein 1) ASNSD1 NS3TP1 Nbla00058 Homo sapiens (Human) adipose tissue development [GO:0060612]; asparagine biosynthetic process [GO:0006529]; skeletal muscle tissue development [GO:0007519]; transdifferentiation [GO:0060290] asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066] EVIQQFIDVLSVAVKK;LLLRLAAVELGLTASALLPKR;VEAEENDTQILFNYLSSCK;VIGDHGK 4 9.8 0.78481 0.023798 0 0 0 0 0 2.7876 0 0 0 8.72332 3.05302 4.11711 Q9NWM0 SMOX_HUMAN Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) SMOX C20orf16 SMO UNQ3039/PRO9854 Homo sapiens (Human) polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] polyamine oxidase activity [GO:0046592]; spermine oxidase activity [GO:0052901] CDDEAVAEICTEMLR 1 2.7 0.78272 0.023279 0 8.98897 0 0 0 0 0 0 0 0 0 0 Q9NWM3 CUED1_HUMAN CUE domain-containing protein 1 CUEDC1 Homo sapiens (Human) ubiquitin binding [GO:0043130] LEFNQAMDDFK;QYLERDRLK 2 5.6 0.96673 -1.2669 0 0 0 0 0 0 0 0 7.82509 0 0 0 Q9NWQ4 GPT2L_HUMAN G patch domain-containing protein 2-like GPATCH2L C14orf118 KIAA1152 Homo sapiens (Human) nucleus [GO:0005634] ISHIISDPR 1 1.9 0.90998 -0.31509 0 0 0 0 0 0 0 3.80911 0 0 0 10.7807 Q9NWR8 MCUB_HUMAN "Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B)" MCUB CCDC109B Homo sapiens (Human) calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of calcium import into the mitochondrion [GO:0110099]; positive regulation of skeletal muscle satellite cell differentiation [GO:1902726]; regulation of macrophage activation [GO:0043030]; skeletal muscle tissue regeneration [GO:0043403] calcium channel complex [GO:0034704]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; uniplex complex [GO:1990246] calcium channel inhibitor activity [GO:0019855] IAYDVQCPK;LLPTPGTWRPARPWPLPPPPQVLRVK 2 10.4 0.91513 -0.3675 11.3094 0 0 0 0 0 10.5414 10.3547 10.344 0 0 12.4972 Q9NWS0 PIHD1_HUMAN PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) PIH1D1 NOP17 Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; epithelial cell differentiation [GO:0030855]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]; TORC1 complex assembly [GO:1905669] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] ATPase binding [GO:0051117]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901] IPMSLGEPHAELDAK;NRPFMGSISQQNIRSEQRPR;SEQRPRIQELGDLYTPAPGR 3 16.9 0.955 -0.8052 0 0 8.72942 0 0 0 0 0 0 12.1269 0 14.2294 Q9NWS1 PARI_HUMAN PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP) PARPBP C12orf48 PARI Homo sapiens (Human) DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] VQLLARKIIFSYLNLLVNSK 1 3.5 0.46572 0.19077 0 0 0 0 5.0703 0 0 0 0 0 0 0 Q9NWS6 F118A_HUMAN Protein FAM118A FAM118A C22orf8 Homo sapiens (Human) membrane [GO:0016020] identical protein binding [GO:0042802] DSVEKTTNR;DSVEKTTNRSEQK;MDSVEKTTNRSEQK;TTNRSEQK 4 3.9 0.97235 -2.6811 0 0 8.03408 0 0 0 0 0 0 0 0 4.99318 Q9NWS8 RMND1_HUMAN Required for meiotic nuclear division protein 1 homolog RMND1 C6orf96 Homo sapiens (Human) positive regulation of mitochondrial translation [GO:0070131]; translation [GO:0006412] mitochondrion [GO:0005739] TCQFLSIGR;VTHKPNLLGSKWFIKILK 2 6 0.91309 -0.32883 0 0 0 0 4.66925 0 0 0 0 9.99449 0 0 Q9NWS9 ZN446_HUMAN Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) ZNF446 ZKSCAN20 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; extracellular space [GO:0005615]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RHFCSDCGRAFDWK;SQKELYWDAMLEK 2 6 0.93607 -0.53622 0 0 0 0 5.28329 9.41155 0 0 0 0 0 0 Q9NWT1 PK1IP_HUMAN p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84) PAK1IP1 PIP1 WDR84 Homo sapiens (Human) "cell population proliferation [GO:0008283]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of signal transduction [GO:0009968]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit biogenesis [GO:0042273]; roof of mouth development [GO:0060021]" nucleolus [GO:0005730] protein kinase inhibitor activity [GO:0004860] FVVTGSK;GLTGDSKK 2 3.8 0.94401 -0.62813 0 0 0 9.1727 9.06474 0 0 0 0 0 0 9.30563 Q9NWT6 HIF1N_HUMAN Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) HIF1AN FIH1 Homo sapiens (Human) negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] [protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxygen sensor activity [GO:0019826]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] AATAAEAVASGSGEPR;SNREEMK 2 6.6 0.96648 -1.2827 0 0 0 0 0 0 0 0 0 0 7.23419 0 Q9NWU1 OXSM_HUMAN "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)" OXSM Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315] LIGGESGIVSLVGEEYK 1 3.7 0.78553 0.02486 8.71723 0 0 0 0 0 0 0 10.2096 0 0 0 Q9NWU2 GID8_HUMAN Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) GID8 C20orf11 TWA1 Homo sapiens (Human) positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] protein homodimerization activity [GO:0042803] LIMNYLVTEGFK 1 5.3 0.80642 0.012236 3.29967 0 0 0 0 0 0 0 0 0 0 0 Q9NWV4 CZIB_HUMAN CXXC motif containing zinc binding protein (UPF0587 protein C1orf123) CZIB C1orf123 Homo sapiens (Human) zinc ion binding [GO:0008270] DWTDYDEK 1 5 0.87868 -0.14057 0 0 0 0 0 0 0 0 0 0 0 5.33382 Q9NWW5 CLN6_HUMAN Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6) CLN6 Homo sapiens (Human) cholesterol metabolic process [GO:0008203]; ganglioside metabolic process [GO:0001573]; glycosaminoglycan metabolic process [GO:0030203]; locomotion involved in locomotory behavior [GO:0031987]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; visual perception [GO:0007601] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730] lysophosphatidic acid binding [GO:0035727]; protein homodimerization activity [GO:0042803]; sulfatide binding [GO:0120146] KHGSVSADEAAR 1 3.5 0.92839 -0.47228 0 0 12.3513 0 0 0 0 0 0 0 0 0 Q9NWW7 CB042_HUMAN Uncharacterized protein C2orf42 C2orf42 Homo sapiens (Human) nucleoplasm [GO:0005654]; nucleus [GO:0005634] CGTYNGTRGLSCK;IITGSDLQVYSVRQR;IKFEYGHHR;NILVVKCK 4 7.8 0.97479 -3.9449 0 0 10.2036 0 6.04656 0 0 0 0 9.54234 0 0 Q9NWX5 ASB6_HUMAN Ankyrin repeat and SOCS box protein 6 (ASB-6) ASB6 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] LLDLGADVNAADK 1 3.1 0.80425 0.012749 0 0 0 0 0 0 0 0 0 0 7.30597 0 Q9NWX6 THG1_HUMAN Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase) THG1L ICF45 Homo sapiens (Human) mitochondrial fusion [GO:0008053]; protein homotetramerization [GO:0051289]; response to oxidative stress [GO:0006979]; stress-induced mitochondrial fusion [GO:1990046]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; tRNA guanylyltransferase activity [GO:0008193] RKTNWFK 1 2.3 0.82985 -0.025129 0 0 0 0 0 0 0 0 0 0 7.25673 0 Q9NWY4 HPF1_HUMAN Histone PARylation factor 1 HPF1 C4orf27 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; regulation of protein ADP-ribosylation [GO:0010835] chromatin [GO:0000785]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] chromatin binding [GO:0003682]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] MVGGGGK;SKFCEADVSSDLR;VGGGGKR 3 6.1 0.87304 -0.11203 12.792 0 8.04056 8.97633 0 9.75196 10.3607 0 0 0 10.2531 0 Q9NWZ3 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; interleukin-1 receptor binding [GO:0005149]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DIKSANILLDEAFTAK;FHSFSFYELK 2 5.7 0.92604 -0.45348 0 0 4.36968 0 0 0 0 0 0 11.4873 0 0 Q9NWZ5 UCKL1_HUMAN Uridine-cytidine kinase-like 1 (EC 2.7.1.48) UCKL1 URKL1 F538 Homo sapiens (Human) CTP salvage [GO:0044211]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849] ALLPALSGLRR 1 2.6 0.73446 0.11197 0 0 0 6.43931 0 0 0 0 0 0 0 0 Q9NWZ5 UCKL1_HUMAN Uridine-cytidine kinase-like 1 (EC 2.7.1.48) UCKL1 URKL1 F538 Homo sapiens (Human) CTP salvage [GO:0044211]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849] IFLLSLLMAEMGVHSVAYAFPR;ISGCRALGAEGSSNAESLDRLLPPVGTGR 2 9.6 0.8895 -0.20475 0 0 6.48393 0 0 0 0 13.4105 0 0 0 0 Q9NX02 NALP2_HUMAN "NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)" NLRP2 NALP2 NBS1 PAN1 PYPAF2 Homo sapiens (Human) apoptotic process [GO:0006915]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; Pyrin domain binding [GO:0032090] ERPPLDVDEMLER;ILAEEPIYIRVEGFLEEDR;KERPPLDVDEMLER;KKPVPVLLGSLLNRVMLPK;LLEEIEEK;VEGFLEEDRRAYFLR 6 6.2 0.76812 0.0575 0 0 4.55723 0 10.718 3.34937 12.9542 0 0 0 3.17218 0 Q9NX05 F120C_HUMAN Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21) FAM120C CXorf17 Homo sapiens (Human) nucleus [GO:0005634] RNA binding [GO:0003723] GVQGFQEFLEK;QQQQQHLHR;YLPMNNR 3 2.5 0.9737 -1.3961 10.775 0 0 0 0 0 0 0 0 0 10.3377 0 Q9NX07 TSAP1_HUMAN tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) TRNAU1AP SECP43 TRSPAP1 Homo sapiens (Human) selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA binding [GO:0000049] FTDELEQK 1 2.8 0.91585 -0.39033 0 0 0 0 0 0 0 0 9.34882 0 0 0 Q9NX24 NHP2_HUMAN H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) NHP2 NOLA2 HSPC286 Homo sapiens (Human) rRNA pseudouridine synthesis [GO:0031118]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance via telomerase [GO:0007004] "box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]" box H/ACA snoRNA binding [GO:0034513]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U3 snoRNA binding [GO:0034511] EVQKFVNKGEK 1 7.2 0.76546 0.063862 0 4.57125 0 0 0 0 0 0 0 0 0 9.85549 Q9NX36 DJC28_HUMAN DnaJ homolog subfamily C member 28 DNAJC28 C21orf55 C21orf78 Homo sapiens (Human) AAEQVMEYQK;KIREYYR 2 4.4 0.97943 -1.8522 0 0 0 0 0 0 9.23026 10.5497 0 0 12.1011 0 Q9NX40 OCAD1_HUMAN OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) OCIAD1 ASRIJ OCIA Homo sapiens (Human) endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of stem cell differentiation [GO:2000736] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739] NITYEELRNKNR 1 4.9 0.60424 0.17675 8.18804 0 0 0 0 0 0 0 0 0 0 0 Q9NX45 SOLH2_HUMAN Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 TEB1 Homo sapiens (Human) cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EAAALLDDCIFNMVLLK;YYALKLEQESKAYQK 2 6.4 0.84075 -0.043201 11.7119 0 0 0 0 0 0 0 9.439 0 0 0 Q9NX47 MARH5_HUMAN E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5) MARCHF5 MARCH5 RNF153 Homo sapiens (Human) positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] GTPase binding [GO:0051020]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VACPQCNAEYLIVFPK 1 5.8 0.60014 0.17744 0 0 0 0 0 0 0 0 0 9.80665 0 0 Q9NX58 LYAR_HUMAN Cell growth-regulating nucleolar protein LYAR PNAS-5 Homo sapiens (Human) erythrocyte development [GO:0048821]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of phagocytosis [GO:0050766]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416] VFFTCNACGESVK;VGAGKRK 2 5.3 0.88218 -0.17596 0 0 0 6.89105 0 0 0 0 0 0 0 10.8149 Q9NX61 T161A_HUMAN Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) TMEM161A UNQ582/PRO1152 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of DNA repair [GO:0045739]; response to retinoic acid [GO:0032526] membrane [GO:0016020] EIQQRVVR 1 1.7 0.91316 -0.33804 0 0 0 0 0 0 0 10.0703 0 0 0 0 Q9NX62 IMPA3_HUMAN "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase)" BPNT2 IMPA3 IMPAD1 Homo sapiens (Human) chondrocyte development [GO:0002063]; chondroitin sulfate metabolic process [GO:0030204]; embryonic digit morphogenesis [GO:0042733]; endochondral ossification [GO:0001958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; post-embryonic development [GO:0009791]; skeletal system development [GO:0001501] cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588] "3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; 3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]" EMLAVSVLAAVRGGDEVRR;MTSGDVLSNR;SQEKADLYIHVTYIKK 3 12.5 0.89353 -0.22036 0 0 0 10.7548 0 0 0 0 5.54517 0 7.06501 0 Q9NX63 MIC19_HUMAN MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) CHCHD3 MIC19 MINOS3 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053] extracellular exosome [GO:0070062]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; SAM complex [GO:0001401] molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902] AAANEQLTR 1 4 0.88929 -0.18673 0 8.44261 8.89276 0 0 0 0 0 0 0 0 0 Q9NX65 ZSC32_HUMAN Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434) ZSCAN32 ZNF434 HCCS5 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APGQQVLDSEKDLK;APGQQVLDSEKDLKVLMK;GVYWHSELQKGLESEPTSR 3 5.3 0.98069 -1.6333 0 0 10.3551 0 0 0 7.91588 0 0 0 0 10.3388 Q9NX74 DUS2_HUMAN tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) DUS2 DUS2L Homo sapiens (Human) antiviral innate immune response [GO:0140374]; tRNA dihydrouridine synthesis [GO:0002943] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] double-stranded RNA binding [GO:0003725]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; protein kinase inhibitor activity [GO:0004860]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264] QYSTKGGMGAALLSDPDKIEK 1 4.3 0.96329 -1.0967 0 0 0 0 0 0 0 9.76825 0 0 0 0 Q9NX77 ENK13_HUMAN Endogenous retrovirus group K member 13-1 Env polyprotein (Envelope polyprotein) (HERV-K_16p13.3 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVK13-1 Homo sapiens (Human) plasma membrane [GO:0005886] structural molecule activity [GO:0005198] LANQINDLR;TNKTKGLPDCPK;VSPYPFK 3 5.8 0.91647 -0.4154 0 0 0 0 0 0 0 0 7.59305 6.65607 0 0 Q9NX95 SYBU_HUMAN Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) SYBU GOLSYN KIAA1472 Homo sapiens (Human) anterograde neuronal dense core vesicle transport [GO:1990048]; axonal transport of mitochondrion [GO:0019896]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of synaptic activity [GO:0060025]; synapse maturation [GO:0060074] axon cytoplasm [GO:1904115]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] SSSSRNR 1 1.1 0.98077 -1.5945 0 0 0 8.11879 0 0 0 0 0 0 0 0 Q9NXA8 SIR5_HUMAN "NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)" SIRT5 SIR2L5 Homo sapiens (Human) epigenetic regulation of gene expression [GO:0040029]; mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein demalonylation [GO:0036046]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566]; response to nutrient levels [GO:0031667] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; zinc ion binding [GO:0008270] TRCTSCGVVAENYKSPICPALSGK 1 7.7 0.62997 0.1736 0 0 0 0 0 0 9.02639 0 0 0 0 0 Q9NXB0 MKS1_HUMAN Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein) MKS1 Homo sapiens (Human) "branching morphogenesis of an epithelial tube [GO:0048754]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor cell stereocilium organization [GO:0060122]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway [GO:0008589]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003271]" centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038] QEILKLENSGGK 1 2.1 0.88709 -0.18474 0 0 0 0 9.46785 0 0 0 0 0 0 0 Q9NXC2 GFOD1_HUMAN Glucose-fructose oxidoreductase domain-containing protein 1 (EC 1.-.-.-) GFOD1 C6orf114 Homo sapiens (Human) extracellular region [GO:0005576] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] LPGVGVFGTSLTARVIIPLLK;TATPLDAFRMTSAAHYYPK;VHGLLKTFVKQTDHIK 3 14.4 0.71087 0.15735 0 0 4.5623 0 4.18848 0 0 9.01675 0 0 0 3.10546 Q9NXC5 MIOS_HUMAN GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) MIOS Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; central nervous system myelin formation [GO:0032289]; negative regulation of TORC1 signaling [GO:1904262]; oligodendrocyte differentiation [GO:0048709]; oligodendrocyte progenitor proliferation [GO:0070444]; positive regulation of TORC1 signaling [GO:1904263]; protein-containing complex localization [GO:0031503] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] SIVKSSLGMVESSR;YIEKLTNEMK 2 2.7 0.94063 -0.5862 0 0 0 0 0 0 0 0 0 10.2206 0 0 Q9NXD2 MTMRA_HUMAN Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) MTMR10 Homo sapiens (Human) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829] IDQRICNAITKSHPQR;IFSHSFVGR;ISLFGTFLFNSPHQRVKQSTVSR;QDYFPSRV 4 12.4 0.98067 -1.6291 0 0 10.4857 0 9.03488 0 0 0 0 0 0 10.9567 Q9NXE4 NSMA3_HUMAN Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) SMPD4 KIAA1418 SKNY Homo sapiens (Human) cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802] metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290] KTDEYLEK;TDLVSPK;VIEDFPAK;VKSHVYSLEGQDCK 4 4.3 0.98018 -1.5958 0 10.7078 0 0 0 0 0 0 0 6.85312 9.25965 0 Q9NXE4 NSMA3_HUMAN Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) SMPD4 KIAA1418 SKNY Homo sapiens (Human) cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802] metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290] KCSPLMPRAAVPR;KTDEYLEK;TDLVSPK;VKSHVYSLEGQDCK 4 8.4 0.9575 -1.0285 0 0 0 0 0 10.0576 0 0 0 0 0 0 Q9NXE8 CWC25_HUMAN Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) CWC25 CCDC49 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type spliceosomal complex [GO:0005684] LDSRDGK;MKLESASTSSLEDR 2 4.9 0.95161 -0.70163 0 0 0 0 0 0 8.02281 0 0 0 0 0 Q9NXF1 TEX10_HUMAN Testis-expressed protein 10 TEX10 L18 Nbla10363 Homo sapiens (Human) mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EDGTLPTNNRK;FFSKIYQTEELR 2 2.5 0.93709 -0.53903 0 0 0 0 0 9.79823 0 0 4.76437 0 0 0 Q9NXF7 DCA16_HUMAN DDB1- and CUL4-associated factor 16 DCAF16 C4orf30 Homo sapiens (Human) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] LLDPSTPVHILREIGLR 1 7.9 0.92027 -0.43765 0 0 0 0 0 0 0 0 0 0 4.90617 0 Q9NXG0 CNTLN_HUMAN Centlein (Centrosomal protein) CNTLN C9orf101 C9orf39 Homo sapiens (Human) centriole-centriole cohesion [GO:0010457]; protein localization to organelle [GO:0033365]; protein-containing complex assembly [GO:0065003]; regulation of protein localization [GO:0032880]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212] protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674] EQENAKLK;GAEVHAMR;KVSIDSLKQR;LLHQQQVSDQRFQTSRQTIK;SLLKQQQEDTETR;VEEFTTFVK 6 4.8 0.98024 -1.5603 0 0 9.63561 0 0 9.16111 0 12.6129 0 0 9.41492 0 Q9NXG2 THUM1_HUMAN THUMP domain-containing protein 1 THUMPD1 Homo sapiens (Human) tRNA modification [GO:0006400] nucleoplasm [GO:0005654] RNA binding [GO:0003723] CDAGGPR 1 2 0.69805 0.16208 8.3753 0 0 0 0 0 0 0 0 0 0 0 Q9NXH3 PP14D_HUMAN Protein phosphatase 1 regulatory subunit 14D (Gastrointestinal and brain-specific PP1-inhibitory protein 1) (GBPI-1) PPP1R14D GBPI Homo sapiens (Human) cytoplasm [GO:0005737] protein serine/threonine phosphatase inhibitor activity [GO:0004865] LTVKYDR 1 4.8 0.89883 -0.25692 0 0 0 0 0 0 0 0 0 0 8.81686 0 Q9NXH8 TOR4A_HUMAN Torsin-4A (Torsin family 4 member A) TOR4A C9orf167 Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; platelet alpha granule lumen [GO:0031093] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EFAVTGCK;FFTFDSPAELPSR;VADVVAR 3 6.6 0.96287 -1.1041 12.8024 0 0 0 0 8.58097 0 0 0 0 0 10.4249 Q9NXH9 TRM1_HUMAN "tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)" TRMT1 Homo sapiens (Human) tRNA modification [GO:0006400]; tRNA N2-guanine methylation [GO:0002940] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine(26)-N2)-dimethyltransferase activity [GO:0160104]; tRNA binding [GO:0000049] MQGSSLWLSLTFRSARVLSR 1 3 0.44299 0.19338 0 5.66556 0 0 0 7.1035 9.29165 0 0 0 0 0 Q9NXI6 RN186_HUMAN E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186) RNF186 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; regulation of autophagosome assembly [GO:2000785] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] TLFCREQK 1 3.5 0.96651 -1.2641 0 0 0 9.60522 9.71141 0 0 0 0 0 0 10.4231 Q9NXK8 FXL12_HUMAN F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ISRVCHR;ISRVCHRWK;LVDDRWLWRHVDLTLYTMRPK;WKRLVDDR 4 9.5 0.92874 -0.46224 0 5.49608 0 0 6.40766 0 0 7.71349 7.86171 0 7.06598 0 Q9NXL2 ARH38_HUMAN Rho guanine nucleotide exchange factor 38 ARHGEF38 Homo sapiens (Human) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DLVLKYK;EVVQPLRNKK;LIQKRYDK 3 3.2 0.97511 -4.0989 0 0 7.79565 0 0 0 0 9.26348 0 0 0 10.2973 Q9NXL6 SIDT1_HUMAN SID1 transmembrane family member 1 SIDT1 Homo sapiens (Human) RNA transport [GO:0050658] lysosome [GO:0005764]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; double-stranded RNA binding [GO:0003725]; RNA transmembrane transporter activity [GO:0051033] AAITLQK;ENQTWNLQRK;LLVTKLK 3 2.9 0.94056 -0.58516 0 0 4.97774 11.4634 10.9611 8.16827 0 10.3467 10.701 6.78869 9.72784 9.48057 Q9NXL9 MCM9_HUMAN DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) MCM9 C6orf61 MCMDC1 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; recombinational interstrand cross-link repair [GO:0036298] chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; enzyme binding [GO:0019899]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] DAALPVK;DDSLDWFDFMATHQSEPKNTVVVSPHPK;ESLFTLPELGDEAFDCDWDEEMRK;ISNSTSQGK;LWSMEKMK;SEKLWSMEK;VILEDDLVDSCK 7 8 0.97505 -3.077 0 6.34476 6.56686 0 11.3329 0 12.7741 0 8.73748 0 14.0187 0 Q9NXP7 GIN1_HUMAN Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) GIN1 TGIN1 ZH2C2 Homo sapiens (Human) DNA integration [GO:0015074] nucleic acid binding [GO:0003676] VLRECHENDSGAHHGISR 1 3.4 0.91986 -0.43822 0 0 0 0 0 0 0 0 0 0 9.1728 0 Q9NXR1 NDE1_HUMAN Nuclear distribution protein nudE homolog 1 (NudE) NDE1 NUDE Homo sapiens (Human) cell division [GO:0051301]; cell migration [GO:0016477]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole centrosome [GO:0031616]; synapse [GO:0045202] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] AIKDQLQK;DLRQELAVQQK;VGALESK 3 7.8 0.98006 -1.8296 0 0 9.66005 0 0 0 0 0 0 0 0 0 Q9NXR7 BABA2_HUMAN BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) BABAM2 BRCC45 BRE Homo sapiens (Human) apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peroxisome targeting sequence binding [GO:0000268]; polyubiquitin modification-dependent protein binding [GO:0031593]; tumor necrosis factor receptor binding [GO:0005164] FLLKLPVDFSNIPTYLLK 1 4.7 0.88562 -0.19498 0 0 0 0 0 0 0 0 0 8.08725 0 0 Q9NXS3 KLH28_HUMAN Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLCAVGGKSGLFACLDS 1 5.7 0.94152 -0.5977 0 0 0 0 0 0 9.51881 0 0 0 0 0 Q9NXV2 KCTD5_HUMAN BTB/POZ domain-containing protein KCTD5 KCTD5 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] DPKSFLYR;QTLCRDPK 2 5.6 0.98025 -1.6499 0 0 8.57387 0 0 5.97499 0 0 0 0 0 0 Q9NXV6 CARF_HUMAN CDKN2A-interacting protein (Collaborator of ARF) CDKN2AIP CARF Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647] granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] p53 binding [GO:0002039]; RNA binding [GO:0003723] ELADLPQNK;KRGISSSNEGVEEPSK;YPQKVMDK 3 5.7 0.97956 -1.8479 0 0 0 0 0 7.16792 0 0 0 0 0 0 Q9NXW2 DJB12_HUMAN DnaJ homolog subfamily B member 12 DNAJB12 Homo sapiens (Human) cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] Hsp70 protein binding [GO:0030544] AIQSNQPDRALR 1 3.2 0.88855 -0.18832 0 0 0 0 0 0 0 6.3659 0 0 0 0 Q9NXW9 ALKB4_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) ALKBH4 ABH4 Homo sapiens (Human) "actomyosin structure organization [GO:0031032]; cleavage furrow ingression [GO:0036090]; demethylation [GO:0070988]; positive regulation of gene expression, epigenetic [GO:0141137]" contractile ring [GO:0070938]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; actin binding [GO:0003779]; broad specificity oxidative DNA demethylase activity [GO:0035516]; demethylase activity [GO:0032451]; DNA N6-methyladenine demethylase activity [GO:0141131]; metal ion binding [GO:0046872]; protein demethylase activity [GO:0140457] AAAAAETPEVLR;QDYGPKVNFR 2 7.3 0.97802 -1.5093 0 10.2276 0 0 0 9.87935 0 0 0 0 0 0 Q9NXX6 NSE4A_HUMAN Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) NSMCE4A C10orf86 PP4762 Homo sapiens (Human) chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" ITGRTAENTFNK;VPVIQEERAMPAQLRR 2 7.3 0.93595 -0.51915 0 0 0 0 0 8.92535 0 0 0 5.59225 0 0 Q9NXZ1 SAGE1_HUMAN Sarcoma antigen 1 (Cancer/testis antigen 14) (CT14) SAGE1 SAGE Homo sapiens (Human) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DLYVTATHSVHEEK;EIDSHCHLR;EVRRFGQNYER;KQDNVLSNVLSGLINMAGASIPAMSSR 4 6.7 0.91504 -0.379 0 9.97842 0 10.9781 0 0 0 10.8946 9.14244 0 0 9.47575 Q9NY12 GAR1_HUMAN H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1) GAR1 NOLA1 Homo sapiens (Human) snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomere maintenance via telomerase [GO:0007004] "box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; telomerase holoenzyme complex [GO:0005697]" box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] GGGRGGFNR 1 4.1 0.97751 -1.5221 0 0 0 8.70453 0 0 0 0 0 0 0 0 Q9NY15 STAB1_HUMAN "Stabilin-1 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1) (FEEL-1) (MS-1 antigen)" STAB1 FEEL1 KIAA0246 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; receptor-mediated endocytosis [GO:0006898] endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044] CECHAGYVGDGLQCLEESEPPVDR;GSACQECQDPNRFGPDCQSVCSCVHGVCNHGPR;GVCMDGMSGSGQCLCR;LLEYKELK;VGLELLR 5 3.4 0.98114 -2.0292 0 0 6.12338 0 3.28583 9.16027 10.7192 0 0 0 4.20163 0 Q9NY25 CLC5A_HUMAN C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) CLEC5A CLECSF5 MDL1 Homo sapiens (Human) cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; virus receptor activity [GO:0001618] SYGTVCPK 1 4.3 0.91798 -0.40157 0 0 0 0 0 0 8.62289 0 8.75465 0 11.6402 0 Q9NY26 S39A1_HUMAN Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1) SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71 Homo sapiens (Human) embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; monoatomic cation transport [GO:0006812]; zinc ion transmembrane transport [GO:0071577] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] inorganic cation transmembrane transporter activity [GO:0022890]; signaling receptor binding [GO:0005102]; zinc ion transmembrane transporter activity [GO:0005385] ILKVILLLAGFALLTGLLFIQI;VILLLAGFALLTGLLFIQI 2 9.9 0.81502 -0.0044 0 0 0 0 0 0 0 0 0 6.68636 3.97655 0 Q9NY28 GALT8_HUMAN Probable polypeptide N-acetylgalactosaminyltransferase 8 (EC 2.4.1.41) (Polypeptide GalNAc transferase 8) (GalNAc-T8) (pp-GaNTase 8) (Protein-UDP acetylgalactosaminyltransferase 8) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8) GALNT8 Homo sapiens (Human) O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] ALFIGLTLAIAVNLLLVFSSK;ELPLHLNKR;LFPHSQLFR;LPKALFIGLTLAIAVNLLLVFSSK 4 6.6 0.95459 -0.79926 10.9154 0 0 0 0 0 10.2227 0 8.45742 0 0 0 Q9NY30 BTG4_HUMAN Protein BTG4 (BTG family member 4) (Protein PC3b) BTG4 PC3B Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] LMTILFETYRSHWHSDCPSK;SIYQVENLK;VGLLGNTYHGSQK 3 18.8 0.95418 -0.93059 0 7.55582 0 0 8.61864 8.89448 0 0 0 12.3759 0 0 Q9NY33 DPP3_HUMAN Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) DPP3 Homo sapiens (Human) protein catabolic process [GO:0030163]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270] ELPWPPTFEKDK;LTFLEEDDK 2 2.8 0.95518 -0.96971 0 0 0 0 0 9.78854 0 0 0 0 0 0 Q9NY37 ASIC5_HUMAN Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Human intestine Na(+) channel) (HINaC) ASIC5 ACCN5 HINAC Homo sapiens (Human) sodium ion transmembrane transport [GO:0035725] plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280]; proton channel activity [GO:0015252] NKGFYLNNSTLLDCEFFGKPCSPK;RVLWLVVVLGSVSLVTWQIYIR;YLSKKLNQSR 3 11.1 0.42028 0.19906 0 0 0 0 0 0 0 10.6263 0 0 0 0 Q9NY43 BARH2_HUMAN BarH-like 2 homeobox protein BARHL2 Homo sapiens (Human) amacrine cell differentiation [GO:0035881]; cell fate determination [GO:0001709]; neuron migration [GO:0001764]; positive regulation of translation [GO:0045727]; regulation of axon extension [GO:0030516]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" ARTAFSDHQLNQLERSFER;EITSSRESPPVR 2 8 0.95215 -0.73949 0 0 0 0 0 0 0 8.73853 0 0 0 11.3311 Q9NY46 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) SCN3A KIAA1356 NAC3 Homo sapiens (Human) behavioral response to pain [GO:0048266]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during action potential [GO:0086010]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; sarcoplasm [GO:0016528]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] GKEVRENQK;KLGSKKPQKPIPRPANK;MRECFQK;TISVIPGLKTIVGALIQSVK;TLRALRPLRALSR;VLRALKTISVIPGLK 6 3.6 0.97772 -1.5196 0 0 0 0 0 0 0 0 0 0 7.83048 0 Q9NY47 CA2D2_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) muscle cell development [GO:0055001]; neuromuscular junction development [GO:0007528]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; regulation of multicellular organism growth [GO:0040014]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; rhythmic synaptic transmission [GO:0060024] GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] EIYKDNR;LVEKVAGDIESLLDR 2 1.9 0.97707 -2.2364 0 0 11.2527 9.1074 0 0 0 0 0 0 0 0 Q9NY61 AATF_HUMAN Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) AATF CHE1 DED HSPC277 Homo sapiens (Human) cell adhesion [GO:0007155]; embryonic cleavage [GO:0040016]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mitotic cell cycle [GO:0007346]; ribosomal small subunit biogenesis [GO:0042274] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667] leucine zipper domain binding [GO:0043522]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tau protein binding [GO:0048156] SHSAKTPGFSVQSISDFEK 1 3.4 0.91633 -0.43299 0 0 0 0 0 0 0 0 7.76288 0 0 0 Q9NY74 ETAA1_HUMAN Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) ETAA1 ETAA16 Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297] cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654] protein serine/threonine kinase activator activity [GO:0043539] EEEEKNRK;FSPNSNK;LTQQQDIR;QEALVRR;TAHVTDQKEICTFNSK;TYDRELIDAEYR 6 7.1 0.97647 -2.2885 12.9398 0 0 0 0 0 9.22236 0 0 11.5946 8.62132 0 Q9NY93 DDX56_HUMAN Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56) DDX56 DDX21 NOH61 Homo sapiens (Human) defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480]; positive regulation of neuron projection development [GO:0010976]; rRNA processing [GO:0006364] cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613] ATGPVVEQAVR;SLLCHLPR 2 3.5 0.95382 -0.89647 0 0 0 0 0 0 0 7.70162 0 0 0 0 Q9NY97 B3GN2_HUMAN "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (EC 2.4.1.149) (Beta-1,3-N-acetylglucosaminyltransferase 1) (BGnT-1) (Beta-1,3-Gn-T1) (Beta3Gn-T1) (Beta-1,3-galactosyltransferase 7) (Beta-1,3-GalTase 7) (Beta3Gal-T7) (Beta3GalT7) (b3Gal-T7) (Beta-3-Gx-T7) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2) (BGnT-2) (Beta-1,3-Gn-T2) (Beta-1,3-N-acetylglucosaminyltransferase 2) (Beta3Gn-T2) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7)" B3GNT2 B3GALT7 B3GNT1 Homo sapiens (Human) axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]; sensory perception of smell [GO:0007608] Golgi membrane [GO:0000139] "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" GEVIIPK;KPFLLLAIK 2 4 0.94451 -0.63679 0 0 0 6.21323 3.32841 0 0 0 0 0 0 9.17635 Q9NY99 SNTG2_HUMAN Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5) SNTG2 Homo sapiens (Human) central nervous system development [GO:0007417] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; syntrophin complex [GO:0016013] actin binding [GO:0003779]; neuroligin family protein binding [GO:0097109]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198] ELEFQDLR;ELTLQNMKMANK 2 3.7 0.95244 -0.73881 0 0 0 9.58509 0 0 0 0 0 0 0 9.89851 Q9NYA1 SPHK1_HUMAN Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-) SPHK1 SK1 SPHK SPK Homo sapiens (Human) blood vessel development [GO:0001568]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA biosynthetic process [GO:0071897]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ceramide biosynthetic process [GO:1900060]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of smooth muscle contraction [GO:0045987]; protein acetylation [GO:0006473]; regulation of endocytosis [GO:0030100]; regulation of endosomal vesicle fusion [GO:1905364]; regulation of interleukin-1 beta production [GO:0032651]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of phagocytosis [GO:0050764]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to tumor necrosis factor [GO:0034612]; sphingoid catabolic process [GO:0046521]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] acetyltransferase activity [GO:0016407]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; D-erythro-sphingosine kinase activity [GO:0017050]; DNA binding [GO:0003677]; lipid binding [GO:0008289]; lipid kinase activity [GO:0001727]; magnesium ion binding [GO:0000287]; protein phosphatase 2A binding [GO:0051721]; sphingosine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036] ALQLFRSHVQPLLAEAEISFTLMLTER;LAYLPVGR 2 7.4 0.91823 -0.43633 11.0307 0 0 0 0 0 0 0 0 0 0 0 Q9NYA3 GOG6A_HUMAN Golgin subfamily A member 6A (Golgin linked to PML) (Golgin-like protein) GOLGA6A GLP GOLGA6 Homo sapiens (Human) Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] EATSSFMDLPK;LAQKEEEMK;LCEQNERLREQQK;LLELQELVLPLVGNHEGHGK;LQKQEKR;LQYSLQRIQELER 6 10.5 0.97512 -3.9911 0 0 0 6.87504 0 0 0 9.92926 0 9.48309 0 0 Q9NYA4 MTMR4_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11)" MTMR4 KIAA0647 ZFYVE11 Homo sapiens (Human) midbody abscission [GO:0061952]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of endocytic recycling [GO:2001136]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; phagosome maturation [GO:0090382]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; R-SMAD binding [GO:0070412]" NGQLLENPR;QIEAGYKQEVEQLRR 2 2 0.98087 -1.7316 0 0 0 0 0 0 0 0 0 7.81986 0 0 Q9NYB0 TE2IP_HUMAN Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) TERF2IP DRIP5 RAP1 PP8000 Homo sapiens (Human) "intracellular signal transduction [GO:0035556]; negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of telomere maintenance [GO:0032204]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomere maintenance via telomere lengthening [GO:0010833]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]" G-rich strand telomeric DNA binding [GO:0098505]; phosphatase binding [GO:0019902]; telomeric DNA binding [GO:0042162] MLVEATR;TPDLPEEEYVK;YLKHLRGQEHK 3 7.3 0.98089 -1.738 0 0 0 10.0872 0 0 0 0 9.11022 0 0 0 Q9NYB5 SO1C1_HUMAN Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter) SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; positive regulation of thyroid hormone generation [GO:2000611]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone transport [GO:0070327]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] VLAGIPAPVYFGVLIDTSCLK 1 2.9 0.89691 -0.24051 0 0 0 0 0 10.2425 0 0 0 0 0 0 Q9NYB9 ABI2_HUMAN Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) ABI2 ARGBPIA Homo sapiens (Human) actin polymerization or depolymerization [GO:0008154]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; lens fiber cell morphogenesis [GO:0070309]; mitophagy [GO:0000423]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]; regulation of dendritic spine morphogenesis [GO:0061001]; zonula adherens assembly [GO:0045186] actin-based cell projection [GO:0098858]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; SCAR complex [GO:0031209] cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; proline-rich region binding [GO:0070064]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625] SYLEKVVAIYDYTK;VVAIYDYTK 2 2.7 0.95545 -0.9333 0 0 0 0 0 10.4748 0 0 0 0 0 0 Q9NYC9 DYH9_HUMAN Dynein axonemal heavy chain 9 (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9) DNAH9 DNAH17L DNEL1 KIAA0357 Homo sapiens (Human) cell projection organization [GO:0030030]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; distal portion of axoneme [GO:0120135]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AEFSKWWLTEFK;ALAEYLDTKR;ALDNFTQDTLEMCSR;GNALSQQVQQMHEEFQEMYR;ITHPCMESAEGK;KLQVVSDTLSFFK;KQVAQLKTLITMLIGQLSK;KVAITVKQQVAPLQANEVTLLR;LVGGLASENVR;LYLHESNR;RMQQKYEDMLSLLEK;SIQDAIRDK;STWDLIRLYLHESNR;TLEDSLLSR;TLMERVQR;VEFSGVR;VELEFWKSRYEDLK;VTLCFSPVGNKLR;VTQIGQK;WIKNKYGEDLR;YEDLKYIYNQLRTITVR;YIYNQLR 22 5.7 0.97815 -8.2655 0 11.8182 12.5655 5.75836 14.4578 12.1426 8.56423 12.045 11.0966 12.7772 12.6591 0 Q9NYD6 HXC10_HUMAN Homeobox protein Hox-C10 (Homeobox protein Hox-3I) HOXC10 HOX3I Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuromuscular process [GO:0050905]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; spinal cord motor neuron cell fate specification [GO:0021520] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" ASLNPRAEHLESPQLGGKVSFPETPK;RDEGSSPSLALNTYPSYLSQLDSWGDPK 2 15.8 0.085404 0.38302 0 0 0 0 10.8326 8.56251 0 0 0 0 0 0 Q9NYF0 DACT1_HUMAN Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein) DACT1 DPR1 HNG3 Homo sapiens (Human) "embryonic hindgut morphogenesis [GO:0048619]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube development [GO:0021915]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein stability [GO:0031647]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; histone deacetylase binding [GO:0042826]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] ASHNLKK;NSSLKHR;VVQPLKK 3 2.5 0.74471 0.099406 0 0 0 0 5.55124 0 0 6.78973 0 6.75141 4.2499 0 Q9NYF3 FA53C_HUMAN Protein FAM53C FAM53C C5orf6 Homo sapiens (Human) protein import into nucleus [GO:0006606] nucleus [GO:0005634] GLRNLPR;HEEDPRR 2 3.6 0.89689 -0.23426 0 0 0 10.7464 0 0 0 0 0 6.76871 0 0 Q9NYF5 FA13B_HUMAN Protein FAM13B (GAP-like protein N61) FAM13B C5orf5 FAM13B1 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] LEHIEELPEEGAEK 1 1.5 0.79555 0.015328 0 6.56255 0 0 0 0 0 0 0 0 0 0 Q9NYF8 BCLF1_HUMAN Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) BCLAF1 BTF KIAA0164 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] DLFDYSPPLHK;EASKEKGSEK;EEEFKTHHEMK;FNDSEGDDTEETEDYRQFR;FTDEESR;NLDAREK;SIFDHIK;SNSRSHSSRSK;SPRSSSSRSSSPYSK;TIAPQNAPR;VFKEENQKGDK;YHRGGYRPVWNR 12 14.1 0.97627 -5.3282 11.4653 0 9.88388 0 8.32576 10.5959 0 0 10.6086 7.93499 0 0 Q9NYG5 APC11_HUMAN Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein) ANAPC11 HSPC214 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; ubiquitin-dependent protein catabolic process [GO:0006511] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cullin family protein binding [GO:0097602]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] MAFNGCCPDCK 1 13.1 0.89707 -0.23576 0 0 0 5.85372 0 0 0 0 0 0 0 0 Q9NYG8 KCNK4_HUMAN Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (K2P4.1) (Two pore K(+) channel KT4.1) KCNK4 TRAAK Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; cellular response to alkaline pH [GO:0071469]; cellular response to arachidonate [GO:1904551]; cellular response to fatty acid [GO:0071398]; cellular response to mechanical stimulus [GO:0071260]; cellular response to temperature stimulus [GO:0071502]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; memory [GO:0007613]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; response to ultrasound [GO:1990478]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951] node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705] identical protein binding [GO:0042802]; mechanosensitive potassium channel activity [GO:0098782]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; temperature-gated cation channel activity [GO:0097604] SPSPPEK 1 1.8 0.91236 -0.32816 0 0 0 0 7.51041 0 0 0 7.74322 0 7.09276 0 Q9NYH9 UTP6_HUMAN U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) UTP6 C17orf40 HCA66 MHAT Homo sapiens (Human) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] DSGTMWQLK;KEKEEFEK 2 2.8 0.9172 -0.41244 0 4.00648 0 0 0 0 0 0 0 10.3442 7.45187 0 Q9NYI0 PSD3_HUMAN PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) PSD3 EFA6D EFA6R HCA67 KIAA0942 Homo sapiens (Human) regulation of ARF protein signal transduction [GO:0032012] postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] DHYLEFEK;FFDFTGMTLDQSLRYFFK;QHLEKTPKPER;TLPAGQK 4 4.2 0.98076 -1.6312 0 0 0 0 7.96145 0 0 9.06256 0 0 10.4504 0 Q9NYJ7 DLL3_HUMAN Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3) DLL3 Homo sapiens (Human) cell differentiation [GO:0030154]; compartment pattern specification [GO:0007386]; negative regulation of neurogenesis [GO:0050768]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; paraxial mesoderm development [GO:0048339]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756] membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] AGFAGPR 1 1.1 0.6413 0.17271 7.49025 0 0 0 0 0 0 0 0 0 0 0 Q9NYJ8 TAB2_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) TAB2 KIAA0733 MAP3K7IP2 Homo sapiens (Human) defense response to bacterium [GO:0042742]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] AIGNNSATSPR;CEQCEMPRHF;LEPPQRNNSSK;NQIEIKLEPPQRNNSSK 4 5.5 0.97674 -4.7859 0 0 0 0 0 10.5076 0 8.61651 0 14.5872 0 7.12959 Q9NYK1 TLR7_HUMAN Toll-like receptor 7 TLR7 UNQ248/PRO285 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; response to cGMP [GO:0070305]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224] cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] double-stranded RNA binding [GO:0003725]; pattern recognition receptor activity [GO:0038187]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197] DAFLNLTK;DAFLNLTKLKVLSLK;IAFYLSHQRLMDEK;LHSNSLQHVPPRWFK;QILILFNIILISK;QILILFNIILISKLLGAR;RQILILFNIILISK;RQILILFNIILISKLLGAR;VDVIILIFLEKPFQKSKFLQLR 9 8.1 0.96783 -1.3272 0 0 0 7.65112 0 4.7591 7.23055 0 0 9.21711 0 6.61349 Q9NYK5 RM39_HUMAN "Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5)" MRPL39 C21orf92 MRPL5 RPML5 MSTP003 PRED22 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] nucleotide binding [GO:0000166]; RNA binding [GO:0003723] EKARQLSLTPR;LDEWMPTKENLR 2 6.8 0.97863 -2.1153 0 0 0 10.0414 0 10.2818 0 0 0 0 0 0 Q9NYK6 EURL_HUMAN Protein EURL homolog EURL C21orf14 C21orf38 C21orf91 YG81 Homo sapiens (Human) cerebral cortex neuron differentiation [GO:0021895]; positive regulation of dendritic spine development [GO:0060999] LLPQFDSQVPK 1 3.7 0.8978 -0.23544 0 0 0 0 7.9357 0 0 0 0 0 0 0 Q9NYL2 M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) MAP3K20 MLK7 MLTK ZAK HCCS4 Homo sapiens (Human) cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; limb development [GO:0060173]; MAPK cascade [GO:0000165]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptotic inflammatory response [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011] DVTFNTNLPDAEILKMTKPPFVMEKWIVGIAK;NERLTIPSSCPRSFAELLHQCWEADAK;NKYGRGSISLNSSPR;SSSPTQYGLTK 4 10.6 0.96384 -1.1812 0 11.2712 4.68179 0 10.1158 4.29822 12.9758 0 0 0 0 0 Q9NYL2 M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) MAP3K20 MLK7 MLTK ZAK HCCS4 Homo sapiens (Human) cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; limb development [GO:0060173]; MAPK cascade [GO:0000165]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptotic inflammatory response [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011] NERLTIPSSCPRSFAELLHQCWEADAK;TITRLNEEVNQRSE 2 13.1 0.9655 -1.124 0 0 0 0 0 0 8.13473 0 0 0 0 0 Q9NYL4 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (19 kDa FK506-binding protein) (19 kDa FKBP) (FKBP-19) (FK506-binding protein 11) (FKBP-11) (Rotamase) FKBP11 FKBP19 UNQ336/PRO535 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] AIIPSHLAYGK;AIIPSHLAYGKRGFPPSVPGTK;IIDTSLTRDPLVIELGQK 3 27.4 0.97705 -2.1731 0 0 0 11.7731 0 0 9.08916 0 0 0 0 0 Q9NYM9 BET1L_HUMAN BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) BET1L GS15 Homo sapiens (Human) "protein transport [GO:0015031]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484] SGQDNRK 1 6.3 0.92986 -0.47483 0 0 0 0 0 0 10.4763 10.5259 0 0 0 0 Q9NYN1 RASLC_HUMAN Ras-like protein family member 12 (EC 3.6.5.2) (Ras-like protein Ris) RASL12 RIS Homo sapiens (Human) plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] SPLTRPLFISEER 1 4.9 0.68531 0.16281 0 0 0 0 7.73179 0 0 0 0 0 0 0 Q9NYP8 EPCIP_HUMAN Exosomal polycystin-1-interacting protein (B37) (Polycystin-1-interacting protein 1) EPCIP C21orf120 C21orf62 CU062 Homo sapiens (Human) mitocytosis [GO:0160040] extracellular exosome [GO:0070062]; migrasome [GO:0140494] identical protein binding [GO:0042802] DCDYSLANLMCNCK 1 6.4 0.80048 0.014571 0 0 0 0 5.99713 0 0 0 0 6.40655 5.97088 6.25285 Q9NYQ3 HAOX2_HUMAN "2-Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)" HAO2 HAOX2 GIG16 Homo sapiens (Human) fatty acid alpha-oxidation [GO:0001561]; fatty acid oxidation [GO:0019395] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] (S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181] ALALGAK;IRLRPRYLR;TGNDVLKALALGAKCIFLGRPILWGLACK 3 10.8 0.72214 0.13155 0 0 4.51671 0 0 0 0 0 0 0 0 3.69176 Q9NYQ6 CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) CELSR1 CDHF9 FMI2 Homo sapiens (Human) "apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lateral sprouting involved in lung morphogenesis [GO:0060490]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AFEAGIWWPQTK;GAVHSTPK;HLVTMTLDYGMDQNK;LLCALRR;RVSGAGRPLPLQVRLVAR;TTPQTTRPGPGTEREAPISR;VPRFDTIHEEFPR;VSGAGRPLPLQVRLVAR 8 3.1 0.97419 -2.4527 8.82165 0 0 7.84134 0 0 0 6.75849 13.1033 11.3396 9.25692 0 Q9NYQ6 CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) CELSR1 CDHF9 FMI2 Homo sapiens (Human) "apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lateral sprouting involved in lung morphogenesis [GO:0060490]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] EGGYTCECFEDFTEIS;LLCALRR;RVSGAGRPLPLQVRLVAR;VSGAGRPLPLQVRLVAR 4 2.9 0.65148 0.17067 0 0 0 0 0 0 0 0 0 0 0 4.10005 Q9NYQ7 CELR3_HUMAN Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) "cell-cell adhesion [GO:0098609]; dopaminergic neuron axon guidance [GO:0036514]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ATTSGAERTAPRR;DLDPQPPPLPLSPQR;GAGAAVR;LHFCDSGPCK;TAAALDR;TGTFGVLMDASPR;VTAQDHGSPR 7 2.3 0.98092 -2.0255 10.0835 11.6346 11.7317 0 0 0 15.0703 15.0376 15.1114 14.9633 15.1723 12.8314 Q9NYQ8 FAT2_HUMAN Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; epithelial cell migration [GO:0010631]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ILEPEALK;LSSLKFEK;VGASDGVFR 3 0.6 0.9803 -2.0049 0 0 0 0 0 0 0 0 12.2613 0 0 0 Q9NYR8 RDH8_HUMAN Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2) RDH8 PRRDH SDR28C2 Homo sapiens (Human) estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; visual perception [GO:0007601] cytosol [GO:0005829]; plasma membrane [GO:0005886] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] AVLPGMK 1 2.3 0.90851 -0.30954 0 0 0 0 0 8.5749 8.98769 0 9.84869 0 0 0 Q9NYR9 KBRS2_HUMAN NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2) NKIRAS2 KBRAS2 Homo sapiens (Human) inflammatory response [GO:0006954]; lung alveolus development [GO:0048286]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; Ral protein signal transduction [GO:0032484]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129] cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924] GVREQVR;LWEVSVADR 2 8.4 0.95224 -0.7547 0 0 0 0 0 0 0 0 0 9.70338 13.0861 0 Q9NYS0 KBRS1_HUMAN NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1) NKIRAS1 KBRAS1 Homo sapiens (Human) lung alveolus development [GO:0048286]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; Ral protein signal transduction [GO:0032484]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924] TLIEPFTLLASKLSQPQSK 1 9.9 0.82562 -0.020483 0 0 0 0 0 0 0 0 9.51552 0 0 0 Q9NYS7 WSB2_HUMAN WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) WSB2 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein polyubiquitination [GO:0000209] cytosol [GO:0005829] RVDRESR 1 1.7 0.9716 -1.3483 12.2416 0 0 0 0 0 0 0 0 0 0 0 Q9NYT6 ZN226_HUMAN Zinc finger protein 226 ZNF226 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CDACGKSFSR;SLTCVERGK 2 2.4 0.95145 -0.71426 11.6491 0 0 0 0 0 0 3.34085 11.3531 0 0 0 Q9NYU1 UGGG2_HUMAN UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1) UGGT2 UGCGL2 UGT2 Homo sapiens (Human) endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] EVIPHMAK;GLWDSIKSFTVSLHKENK;MAPAKATNVVR;NFHNLVLFIDPAQEYTLDFIK;SLTRIAVNQHMREEIK;TFLIEGMDK;TRPYLFKGDHKFPTNK;YDEERKAGASFYK;YHISALYVVDLK 9 8.2 0.97516 -4.1792 7.41481 0 8.60244 11.4 0 0 0 6.13783 12.2601 11.8566 12.3317 0 Q9NYU2 UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) UGGT1 GT UGCGL1 UGGT UGT1 UGTR Homo sapiens (Human) 'de novo' post-translational protein folding [GO:0051084]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] DLHPDLEGQLK;DLSQNFPTK;EAQRLAPLLLVLAQLINMNLR;HSAIKLRPK;NTKTPVKFWFLK;YHISALYVVDLK 6 4.8 0.93693 -0.55362 0 11.0006 0 0 4.57283 5.58259 0 0 0 6.8334 9.85904 0 Q9NYV4 CDK12_HUMAN "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) mRNA processing [GO:0006397]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein autophosphorylation [GO:0046777]; regulation of MAP kinase activity [GO:0043405]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366] cyclin K-CDK12 complex [GO:0002944]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] DTGELVALKK;EIKILRQLIHR;ISGSSKR;LADFGLAR;RSSSYERSGSYSGR;SGSMKDRISGSSK;VPLALHPVVGQPFLK 7 4.8 0.98087 -1.7319 6.2951 7.65835 10.7561 0 9.20655 9.97799 0 0 3.74749 8.6393 0 10.534 Q9NYV6 RRN3_HUMAN RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) RRN3 TIFIA Homo sapiens (Human) cytoplasm organization [GO:0007028]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; nucleolus organization [GO:0007000]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription initiation [GO:2000142]; ribosome biogenesis [GO:0042254]; transcription initiation at RNA polymerase I promoter [GO:0006361] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase I core binding [GO:0001042]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181] DLYRDLINIFDK;LPGDAAASSSAVK 2 3.8 0.9515 -0.68874 0 0 0 0 10.8445 0 10.5977 0 0 0 0 0 Q9NYV8 T2R14_HUMAN Taste receptor type 2 member 14 (T2R14) (Taste receptor family B member 1) (TRB1) TAS2R14 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] LRQASLSVLLWLR 1 4.1 0.98052 -1.6267 0 0 11.0028 0 0 0 0 0 0 0 0 0 Q9NYV9 T2R13_HUMAN Taste receptor type 2 member 13 (T2R13) (Taste receptor family B member 3) (TRB3) TAS2R13 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; positive regulation of cytokinesis [GO:0032467] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] FTMTMFSLTPFTVAFISFLLLIFSLQKHLQKMQLNYK;IASFSSPAFLYLKWRVNK;YERNTTWNFSMSDFETFSVSVK 3 25.4 0.88109 -0.15962 0 0 11.2727 6.73796 0 0 0 0 0 0 8.3057 0 Q9NYW1 TA2R9_HUMAN Taste receptor type 2 member 9 (T2R9) (Taste receptor family B member 6) (TRB6) TAS2R9 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] FVKCFLR;INKVMLAILLGSFLISLIISVPK 2 9.6 0.91013 -0.29086 0 0 0 0 0 0 11.7192 0 0 2.85062 0 0 Q9NYW2 TA2R8_HUMAN Taste receptor type 2 member 8 (T2R8) (Taste receptor family B member 5) (TRB5) TAS2R8 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] LYATGSR 1 2.3 0.93608 -0.54589 0 0 0 0 0 0 12.4637 0 12.7755 0 0 0 Q9NYW6 TA2R3_HUMAN Taste receptor type 2 member 3 (T2R3) TAS2R3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] AIRIILSFFFLFLLYFLAFLIASFGNFLPK 1 9.5 0.84161 -0.045328 0 0 0 0 0 0 0 0 0 0 6.82043 0 Q9NYW8 RBAK_HUMAN RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769) RBAK ZNF769 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" TFSHNSSLFRHQR 1 1.8 0.92221 -0.44265 0 0 0 0 0 0 0 0 0 0 7.40574 0 Q9NYX4 CALY_HUMAN Neuron-specific vesicular protein calcyon CALY DRD1IP Homo sapiens (Human) anterograde axonal transport [GO:0008089]; clathrin coat assembly [GO:0048268]; endosomal transport [GO:0016197]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of endocytosis [GO:0045807]; positive regulation of retrograde axon cargo transport [GO:2001019]; postsynaptic neurotransmitter receptor internalization [GO:0098884] axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843] clathrin light chain binding [GO:0032051]; protein-containing complex binding [GO:0044877] LNCSHPEEGR 1 8.1 0.94074 -0.58616 0 0 0 0 0 0 0 0 10.6581 0 0 0 Q9NYY1 IL20_HUMAN Interleukin-20 (IL-20) (Cytokine Zcyto10) IL20 ZCYTO10 UNQ852/PRO1801 Homo sapiens (Human) osteoclast differentiation [GO:0030316]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of inflammatory response [GO:0050727] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-20 receptor binding [GO:0045517]; interleukin-22 receptor binding [GO:0045518] CCLLRHLLRLYLDR 1 8 0.5625 0.18258 0 7.05365 0 0 0 0 0 0 0 0 10.1316 0 Q9NYY3 PLK2_HUMAN Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) PLK2 SNK Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of cellular senescence [GO:2000773]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]" centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP-dependent protein binding [GO:0043008]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EARYTMPSSLLAPAKHLIASMLSK;WVDYSNK;YLHEQEILHR 3 6 0.9533 -0.67524 4.73183 0 0 0 0 9.66945 0 0 0 0 2.9201 0 Q9NYY8 FAKD2_HUMAN "FAST kinase domain-containing protein 2, mitochondrial" FASTKD2 KIAA0971 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial RNA processing [GO:0000963]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]; RNA processing [GO:0006396] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723]; rRNA binding [GO:0019843] DAPIALK;HLNAMGFHVILVNNWEMDKLEMEDAVTFLK;IEDVFTLQVVMK;LEMEDAVTFLKTK;LSDDQKRFEK 5 8.6 0.97827 -2.101 0 3.71238 0 11.9308 0 0 9.50442 0 0 0 10.0824 0 Q9NYZ2 MFRN1_HUMAN Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37) SLC25A37 MFRN MSCP HT015 Homo sapiens (Human) iron import into the mitochondrion [GO:0048250]; positive regulation of hemoglobin biosynthetic process [GO:0046985] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381] SAISCIR;SAISCIRTVWR 2 3.3 0.95491 -0.96444 0 0 0 0 0 0 8.76092 0 0 0 0 9.62395 Q9NYZ3 GTSE1_HUMAN G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) GTSE1 Homo sapiens (Human) "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; microtubule-based process [GO:0007017]" cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654] microtubule binding [GO:0008017] INLFEKEKEMK;MEGGGGR;TEPTRESNRK 3 3.8 0.97383 -2.4622 0 0 0 0 0 0 0 0 0 0 6.78267 0 Q9NYZ4 SIGL8_HUMAN Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2) SIGLEC8 SAF2 Homo sapiens (Human) cell adhesion [GO:0007155]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888] MLLLLLLLPLLWGTK 1 3 0.78366 0.021195 0 0 0 0 4.56456 0 0 0 0 3.01346 0 0 Q9NZ01 TECR_HUMAN "Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)" TECR GPSN2 SC2 Homo sapiens (Human) fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] oxidoreductase activity [GO:0016491]; very-long-chain enoyl-CoA reductase activity [GO:0102758]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099] KHYEVEILDAK;MPIIPFLL;THPQWYPARQSLR;VEPHATIAEIK 4 14 0.95341 -0.73035 0 0 0 0 0 0 0 7.59969 7.472 9.6293 10.1249 11.8823 Q9NZ08 ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154 Homo sapiens (Human) adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; peptide catabolic process [GO:0043171]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] "aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; interleukin-1, type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]" AFLIRLLR;GFFSSLKENGSQLR;LSIEKALDLSLYLK;VGDYFFGK;YQFSLSSTEK 5 5.7 0.97781 -2.161 0 10.3875 0 0 0 0 5.70744 12.2885 0 7.84562 0 0 Q9NZ09 UBAP1_HUMAN Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) UBAP1 NAG20 Homo sapiens (Human) membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ubiquitin binding [GO:0043130] IAEAEAKVNSK;TIEWAEEIKKIEEAER 2 5.4 0.96511 -1.122 0 0 0 0 0 0 0 0 0 0 12.1696 0 Q9NZ20 PA2G3_HUMAN Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 Homo sapiens (Human) acrosome assembly [GO:0001675]; arachidonate secretion [GO:0050482]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288] centriole [GO:0005814]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; metal ion binding [GO:0046872] GTDERQPWPSEPLR 1 2.8 0.92212 -0.44279 0 0 0 0 0 0 0 0 0 2.49157 0 0 Q9NZ43 USE1_HUMAN Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) USE1 USE1L MDS032 Homo sapiens (Human) "lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; secretion by cell [GO:0032940]" COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484] LELNLVR;LTSSSEK 2 5.4 0.94449 -0.63665 0 10.8223 0 0 8.38655 0 0 8.98379 0 0 0 9.04467 Q9NZ52 GGA3_HUMAN "ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)" GGA3 KIAA0154 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of lysosomal protein catabolic process [GO:1905167]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to cell surface [GO:0034394]; protein targeting to lysosome [GO:0006622]; regulation of protein stability [GO:0031647] early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] FHNEVGKFR;LIKSMVKEDEAR 2 2.9 0.90142 -0.26404 0 8.20618 0 0 0 0 0 0 0 0 0 0 Q9NZ52 GGA3_HUMAN "ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)" GGA3 KIAA0154 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of lysosomal protein catabolic process [GO:1905167]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to cell surface [GO:0034394]; protein targeting to lysosome [GO:0006622]; regulation of protein stability [GO:0031647] early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] ALPEEAK;LIKSMVKEDEAR 2 3.2 0.94605 -0.65214 0 0 0 0 5.85592 6.18895 0 0 0 0 0 0 Q9NZ63 TLS1_HUMAN Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) C9orf78 HCA59 Homo sapiens (Human) "chromosome segregation [GO:0007059]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of homologous chromosome segregation [GO:0060629]" "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]" U5 snRNA binding [GO:0030623] LLAEQQNK;NIISTEDAKAR 2 6.6 0.96733 -1.2897 12.9606 0 0 0 0 0 0 12.8144 0 0 0 0 Q9NZ71 RTEL1_HUMAN Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) RTEL1 C20orf41 KIAA1088 NHL Homo sapiens (Human) DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand displacement [GO:0000732]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of DNA recombination [GO:0045910]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere maintenance in response to DNA damage [GO:1904506]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of telomeric loop disassembly [GO:1904535]; regulation of double-strand break repair via homologous recombination [GO:0010569]; replication fork processing [GO:0031297]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomeric loop disassembly [GO:0090657] "chromosome, telomeric region [GO:0000781]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA polymerase binding [GO:0070182]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]" VCPYYLSR;VLECLQQK 2 1.3 0.9638 -1.192 0 0 0 0 0 9.96593 0 0 0 0 0 0 Q9NZ72 STMN3_HUMAN Stathmin-3 (SCG10-like protein) STMN3 SCLIP Homo sapiens (Human) blastocyst hatching [GO:0001835]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; negative regulation of Rac protein signal transduction [GO:0035021]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005] protein domain specific binding [GO:0019904]; tubulin binding [GO:0015631] EAHLAALRER;QAEEKLNYK 2 10.6 0.97267 -2.8149 0 0 0 0 9.37136 0 0 0 0 0 0 0 Q9NZ81 PRR13_HUMAN Proline-rich protein 13 (Taxane-resistance protein) PRR13 TXR1 BM-041 Homo sapiens (Human) cytosol [GO:0005829]; nucleoplasm [GO:0005654] HGKHSSSSSSSSSSDSD 1 11.5 0.92231 -0.44242 0 0 0 0 8.54005 0 0 0 0 0 0 0 Q9NZ94 NLGN3_HUMAN Neuroligin-3 (Gliotactin homolog) NLGN3 KIAA1480 NL3 Homo sapiens (Human) "adult behavior [GO:0030534]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; inhibitory postsynaptic potential [GO:0060080]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; receptor-mediated endocytosis [GO:0006898]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488]; vocalization behavior [GO:0071625]" "asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]" cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023] LGPPSLSLSPKPTVGR 1 1.9 0.78498 0.029517 0 0 0 0 0 0 0 0 0 0 0 10.8464 Q9NZA1 CLIC5_HUMAN Chloride intracellular channel protein 5 (Glutaredoxin-like oxidoreductase CLIC5) (EC 1.8.-.-) CLIC5 Homo sapiens (Human) chloride transport [GO:0006821]; female pregnancy [GO:0007565]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; stereocilium base [GO:0120044] chloride channel activity [GO:0005254]; oxidoreductase activity [GO:0016491] AGIDGESIGNCPFSQR;LHVVKIVAKK;YSCYSDAEGLEEK 3 9.5 0.88151 -0.15699 0 4.17105 0 0 5.24039 0 0 0 0 9.04418 0 0 Q9NZB2 F120A_HUMAN Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) FAM120A C9orf10 KIAA0183 OSSA Homo sapiens (Human) cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] RNA binding [GO:0003723] DLPPAALLYRPVR;LHEWVKRQGNER 2 2.2 0.96527 -1.2376 0 0 0 0 0 0 0 0 0 0 8.03221 0 Q9NZB8 MOCS1_HUMAN "Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]" MOCS1 MIG11 Homo sapiens (Human) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]" EMLDTVR;ITADGNLK;TDVREVSR;TIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAK 4 16.9 0.98 -1.5684 0 0 0 0 0 9.16196 0 9.01198 0 0 0 0 Q9NZE8 RM35_HUMAN "Large ribosomal subunit protein bL35m (39S ribosomal protein L35, mitochondrial) (L35mt) (MRP-L35)" MRPL35 BM-007 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] AVIDRFLRLHCGLWVR;TVKAVIDR 2 10.1 0.97343 -2.5543 0 0 0 10.889 10.6291 0 0 0 13.1033 0 0 0 Q9NZG7 NINJ2_HUMAN Ninjurin-2 (Nerve injury-induced protein 2) NINJ2 Homo sapiens (Human) cell adhesion [GO:0007155]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; tissue regeneration [GO:0042246] plasma membrane [GO:0005886] ENIDLQPGSSDPR 1 9.2 0.89777 -0.23246 0 0 0 0 0 0 0 0 0 0 0 10.3401 Q9NZH4 PTTG3_HUMAN Putative pituitary tumor-transforming gene 3 protein (hPTTG3) (Securin-3) (rcPTTG1) PTTG3P PTTG3 Homo sapiens (Human) chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143] cytoplasm [GO:0005737]; nucleus [GO:0005634] SH3 domain binding [GO:0017124] TNGPLKQK 1 4 0.9817 -1.5889 0 0 0 0 0 0 0 0 0 9.15015 0 0 Q9NZH7 IL36B_HUMAN Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2) IL36B IL1F8 IL1H2 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of T cell differentiation [GO:0045582] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] SIKPVTLHLIACRDTEFSDKEK 1 14 0.5632 0.18276 0 9.28653 0 0 0 0 0 0 0 0 0 0 Q9NZI2 KCIP1_HUMAN A-type potassium channel modulatory protein KCNIP1 (Kv channel-interacting protein 1) (KChIP1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein) KCNIP1 KCHIP1 VABP Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; membrane repolarization [GO:0086009]; muscle contraction [GO:0006936]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart contraction [GO:0008016]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; Kv4.3-KChIP1 channel complex [GO:0071196]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325] FEDFVTALSILLR;QHVDVFFQKMDKNK 2 14.4 0.8297 -0.024282 0 10.8548 0 0 0 7.62659 0 9.29751 0 0 6.36737 0 Q9NZI5 GRHL1_HUMAN Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32) GRHL1 LBP32 MGR TFCP2L2 Homo sapiens (Human) desmosome organization [GO:0002934]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of keratinocyte differentiation [GO:0045616]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" TPDSTFSETFK;YDVPHDKIGK 2 3.4 0.95454 -0.95244 0 0 0 0 0 0 0 11.7205 0 10.3827 8.72908 0 Q9NZI6 TF2L1_HUMAN Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9) TFCP2L1 CRTR1 LBP9 Homo sapiens (Human) cell morphogenesis [GO:0000902]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; epithelial cell maturation [GO:0002070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of growth [GO:0045927]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland development [GO:0007431] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MLFWHTQPEHYNQHNSGSYLR 1 4.4 0.65387 0.16939 0 0 0 0 0 0 0 0 0 6.46995 0 0 Q9NZI7 UBIP1_HUMAN Upstream-binding protein 1 (Transcription factor LBP-1) UBP1 LBP1 Homo sapiens (Human) angiogenesis [GO:0001525]; negative regulation of viral transcription [GO:0032897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RLQYTEHQQLEGWK 1 2.6 0.65338 0.16985 0 0 0 0 0 0 0 0 0 7.5938 0 0 Q9NZI8 IF2B1_HUMAN Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) IGF2BP1 CRDBP VICKZ1 ZBP1 Homo sapiens (Human) "CRD-mediated mRNA stabilization [GO:0070934]; dendrite arborization [GO:0140059]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; pallium cell proliferation in forebrain [GO:0022013]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of cytokine production [GO:0001817]; regulation of mRNA stability involved in response to stress [GO:0010610]" CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] FASASIK;LLVPTQYVGAIIGK;MVIITGPPEAQFK;QQQVDIPLR;TADEVPLK;TVNELQNLTAAEVVVPR;VPASAAGR 7 13.2 0 5.8316 13.1841 12.5443 13.3723 10.249 10.5729 10.2187 0 0 0 0 0 0 Q9NZJ4 SACS_HUMAN Sacsin (DnaJ homolog subfamily C member 29) SACS DNAJC29 KIAA0730 Homo sapiens (Human) negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087] EVTSVVEQAWK;GIQNLGK;ILGTAISNYCK;ILGTAISNYCKK;KAKTLLLVLNK;LDSLGVK;LEKQAFLDQNADRASR;LIMLFPQK;LIMLFPQKLRPR;LINPENMGFEQSGQREPLTVR;LLVDYCFK;QLDPNEMR;SIPSAEVEK;SLPCYKSISGR;TMAKFHQLFK 15 3.1 0.97516 -4.1753 12.3485 0 15.1775 10.7154 7.80329 0 11.6016 0 13.1426 9.45957 9.01324 11.9495 Q9NZJ5 E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) EIF2AK3 PEK PERK Homo sapiens (Human) angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; ossification [GO:0001503]; peptidyl-serine phosphorylation [GO:0018105]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALLLLLLLLGLAAR;ERAISPGLLVRALLLLLLLLGLAAR;GLPAPTAEAAFGLGAAAAPTSATR;ISEKFPSSPK;KENLKDWMNGR;TVRAVGPR;TVRAVGPRSGNEK;VSVADWKVMAFSK 8 8.6 0.97483 -3.2094 0 4.47508 0 9.7698 9.5971 0 0 0 0 0 10.6562 10.0711 Q9NZJ6 COQ3_HUMAN "Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)" COQ3 UG0215E05 Homo sapiens (Human) "glycerol metabolic process [GO:0006071]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]" extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142] "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [GO:0010420]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]; O-methyltransferase activity [GO:0008171]" TAQCHKSFDPVLDK 1 3.8 0.9216 -0.44573 0 0 0 0 7.6708 0 0 0 0 0 0 0 Q9NZJ9 NUDT4_HUMAN "Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4)" NUDT4 DIPP2 KIAA0487 HDCMB47P Homo sapiens (Human) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; calcium-mediated signaling [GO:0019722]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [GO:0106211]; metal ion binding [GO:0046872]; snoRNA binding [GO:0030515]" EVYEEAGVK;LLGIFENQDRKHR;TYDREGFK 3 16.7 0.8684 -0.091498 0 0 0 0 0 0 0 0 9.96622 0 0 0 Q9NZK5 ADA2_HUMAN Adenosine deaminase 2 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1) ADA2 ADGF CECR1 IDGFL Homo sapiens (Human) adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615] 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270] IAEMKEAMR;IAEMKEAMRTLIFPPSMHFFQAK;RVQNVTEFDDSLLR 3 7.2 0.97167 -1.354 0 0 0 10.8776 0 0 9.83118 0 0 11.1813 0 0 Q9NZK7 PA2GE_HUMAN Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E) PLA2G2E Homo sapiens (Human) arachidonate secretion [GO:0050482]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543] NLGTYNRK;RAALCFR;TTCQRLTCECDK 3 19 0.97292 -1.3705 0 0 0 0 0 5.03245 0 0 0 0 0 0 Q9NZL3 ZN224_HUMAN Zinc finger protein 224 (Bone marrow zinc finger 2) (BMZF-2) (Zinc finger protein 233) (Zinc finger protein 255) (Zinc finger protein 27) (Zinc finger protein KOX22) ZNF224 BMZF2 KOX22 ZNF233 ZNF255 ZNF27 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" CEECGKR;EGDFPCQTEAGLSVIHTRQK;LYNCKECGK 3 6.1 0.92771 -0.45855 0 0 0 0 0 12.2067 0 0 0 0 0 7.74113 Q9NZL4 HPBP1_HUMAN Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2) HSPBP1 HSPBP PP1845 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme inhibitor activity [GO:0004857]; molecular sequestering activity [GO:0140313]; ubiquitin protein ligase binding [GO:0031625] EEVEQMKSCLR;LDGFSVLMR;LLDRDACDTVRVK;LLQTCFSSPADDSMDR 4 13.6 0.97987 -1.8746 0 0 0 12.7101 0 0 0 0 9.74973 10.1933 0 0 Q9NZL6 RGL1_HUMAN Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) RGL1 KIAA0959 RGL Homo sapiens (Human) Ras protein signal transduction [GO:0007265]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] FANLDSSVKENQKR;TAKRGCWSNR;TSLTLPR;VQIQQAANKGAR 4 5.6 0.97312 -2.8531 0 0 12.2648 11.1372 0 0 10.0137 0 0 0 10.5725 0 Q9NZL9 MAT2B_HUMAN Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methionine adenosyltransferase complex [GO:0048269]; nucleus [GO:0005634] enzyme binding [GO:0019899]; methionine adenosyltransferase regulator activity [GO:0048270] DVATVCRQLAEKR;EFQQNNWHAVGCGFRRARPK;IPILYGEVEK;VGREKELSIHFVPGSCR 4 18 0.97863 -2.0855 12.0687 13.3542 0 0 0 0 9.63338 0 10.7434 0 0 0 Q9NZM1 MYOF_HUMAN Myoferlin (Fer-1-like protein 3) MYOF FER1L3 KIAA1207 Homo sapiens (Human) blood circulation [GO:0008015]; muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; regulation of neurotransmitter secretion [GO:0046928] caveola [GO:0005901]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543] AEDIPQMDDAFSQTVK;CYVYQAR;DFETIGQNK;DGSNLPILPPQR;EELYMPPLVIK;FIVWRRFK;IDVGFVYDEPGHAVMR;IYPLPDDPSVPAPPR;IYRAEDIPQMDDAFSQTVK;KVDNELNPVWNEILEFDLR;LTIYDWDRLTK;NLVDPFVEVSFAGK;SLGPPGPPFNITPR;STLAEIEDWLDK;VEMTLEILNEK;YYLRVIIWNTKDVILDEK 16 9.5 0.87322 -0.11501 10.9287 0 10.6903 11.0168 0 0 13.1086 0 11.2496 10.2228 11.431 0 Q9NZM3 ITSN2_HUMAN Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) cell differentiation [GO:0030154]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; positive regulation of dendrite extension [GO:1903861] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090] LIKLKLQGQQLPVVLPPIMK;LSEMDSFNNQLK;MPSSENEKAVSPK;TIQDTLNPK;TSGIGRLMVHVIEATELK 5 4.2 0.76504 0.060283 0 3.3238 0 0 0 8.08486 0 0 4.72329 0 11.5845 0 Q9NZM5 NOP53_HUMAN Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) NOP53 GLT GLTSCR2 PICT1 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364] cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723] KSLLLKKPLR;QARREAEADKPR;VQKKSLLLK 3 5.2 0.974 -1.4124 0 11.2947 0 0 0 8.3092 0 0 3.57616 0 0 0 Q9NZM6 PK2L2_HUMAN Polycystin-2-like protein 2 (Polycystin-2L2) (Polycystic kidney disease 2-like 2 protein) (Polycystin-L2) PKD2L2 TRPP5 Homo sapiens (Human) detection of mechanical stimulus [GO:0050982] membrane [GO:0016020] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509] FISFNKTMSQLSSTLSR;LDFELGK 2 3.8 0.95921 -1.0376 0 0 0 0 7.96457 0 0 0 0 0 0 0 Q9NZN1 IRPL1_HUMAN Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1) IL1RAPL1 OPHN4 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; negative regulation of exocytosis [GO:0045920]; neuron differentiation [GO:0030182]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of synapse assembly [GO:0051965]; presynaptic membrane assembly [GO:0097105]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] "NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor binding [GO:0005102]" RLQYEMPFKR 1 1.4 0.67464 0.16661 0 0 0 0 0 0 0 0 0 0 0 9.92026 Q9NZN3 EHD3_HUMAN EH domain-containing protein 3 (PAST homolog 3) EHD3 EHD2 PAST3 Homo sapiens (Human) cilium assembly [GO:0060271]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; Golgi to lysosome transport [GO:0090160]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of Golgi organization [GO:1903358] ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676] ELVNNLAEIYGR;ITGANAKKEMVR;NHEDKMR 3 5.8 0.9813 -1.7101 0 0 0 8.26092 0 6.37133 0 13.3066 0 0 0 0 Q9NZN4 EHD2_HUMAN EH domain-containing protein 2 (PAST homolog 2) EHD2 PAST2 Homo sapiens (Human) cilium assembly [GO:0060271]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; plasma membrane tubulation [GO:0097320]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to plasma membrane [GO:0072659] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904] DIQGLPRHAALRK;GQQPEAIR;KQLILKLPVIFAK;VVGTPEVLR 4 7.9 0.74892 0.084942 0 0 0 0 4.99023 0 0 10.0928 0 0 0 0 Q9NZN5 ARHGC_HUMAN Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DIIPTQMQR;DLFVAERQFAK;IGFLPKIK;LEDYQRR;LLKEIQEAKK;LTKYPLLLDNIAK;NETSVIDQIGEDLLTWFSGPGEEKLK;VLDQVFYQR;YPLLLDNIAKYTEWPTEREK 9 6.7 0.97824 -6.4219 0 0 0 8.84853 9.04193 10.3229 8.05582 9.94704 11.046 13.3103 0 8.92855 Q9NZN9 AIPL1_HUMAN Aryl-hydrocarbon-interacting protein-like 1 AIPL1 AIPL2 Homo sapiens (Human) "apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; phototransduction, visible light [GO:0007603]; protein farnesylation [GO:0018343]; regulation of opsin-mediated signaling pathway [GO:0022400]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] farnesylated protein binding [GO:0001918]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082] LEVWEILLTSMR;VLELEPSMQK 2 5.7 0.91527 -0.34047 0 12.3428 0 0 0 0 11.8411 0 0 0 0 12.2832 Q9NZP6 NPAP1_HUMAN Nuclear pore-associated protein 1 NPAP1 C15orf2 Homo sapiens (Human) cell differentiation [GO:0030154]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; spermatogenesis [GO:0007283] intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] TPLSSGEASSTSR 1 1.1 0.89753 -0.23844 0 0 0 0 0 0 0 0 0 0 6.35304 0 Q9NZQ3 SPN90_HUMAN NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) NCKIPSD AF3P21 SPIN90 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; positive regulation of neuron projection development [GO:0010976]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; postsynapse [GO:0098794] Arp2/3 complex binding [GO:0071933]; cytoskeletal protein binding [GO:0008092]; SH3 domain binding [GO:0017124] GVLQKLIHHRK 1 1.5 0.87167 -0.095325 0 0 3.20602 0 0 0 0 0 0 0 0 0 Q9NZQ7 PD1L1_HUMAN Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 Homo sapiens (Human) "adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor superfamily cytokine production [GO:1903556]; negative regulation of type II interferon production [GO:0032689]; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905404]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of T cell proliferation [GO:0042102]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]" actin cytoskeleton [GO:0015629]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] receptor ligand activity [GO:0048018]; transcription coactivator activity [GO:0003713] INTTTNEIFYCTFRR;VQHSSYR 2 7.6 0.74621 0.088121 0 0 0 0 9.3812 0 0 0 0 0 11.0604 0 Q9NZQ9 TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod) TMOD4 Homo sapiens (Human) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] ELEKYRDIDEDEILR 1 4.3 0.85945 -0.082011 0 0 0 3.298 10.3639 0 0 8.39348 0 0 0 0 Q9NZR1 TMOD2_HUMAN Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod) TMOD2 NTMOD Homo sapiens (Human) actin filament organization [GO:0007015]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; pointed-end actin filament capping [GO:0051694]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745] cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; synapse [GO:0045202] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] ALETNTHVK;LSEEELK;TRVAAAITKNNDLVR;VAAAITK 4 8.8 0.9549 -0.97505 11.9033 13.846 2.84481 0 3.8125 0 0 0 0 0 0 0 Q9NZR2 LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor activity [GO:0005041] AGEFRCKNR;AIALDPRYGILFWTDWDANFPR;CDGEKDCEDGSDEK;CDSQNDCSDNSDEENCKPQTCTLK;CDTVDDCGDGSDEPDDCPEFR;CIPMDLQCDRLDDCGDGSDEQGCR;CNGEYDCADGSDEMDCVTECK;CNGQDDCGDEEDER;CQYYVCHHYCVNSESCTIGDDGSVECVCPTR;DCPENSCSPDYFQCKTTK;DEFHCDSSCSWNQFACSAQK;DEFHCDSSCSWNQFACSAQKCISK;DSEDIFCNCTNGK;FWCDGDFDCADGSDER;GCNGTIR;GVLISHR;IDGTERETILK;IDIFEDYIYGAGPK;IFNRVREK;LDDCGDGSDEQGCR;LYMDGQNCR;LYWTDIK;NLYWSDTEK;NQKCIPVNLRCNGQDDCGDEEDER;NSTRCYCEDGFEITEDGR;RQANSGLICPEFKRPR;SDEKLLYCENR;TDKCIPFWWKCDTVDDCGDGSDEPDDCPEFR;WHCDSDDDCGDGSDEVGCVHSCFDNQFR;WKCDGHEDCKYGEDEK 30 9.4 0.97844 -6.7159 7.2406 9.55154 4.85863 10.9796 11.1523 11.7886 9.80941 11.8802 10.1447 10.6945 9.97456 9.14425 Q9NZS2 KLRF1_HUMAN Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C) KLRF1 CLEC5C ML Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; NK T cell activation [GO:0051132] membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; MHC class I receptor activity [GO:0032393]; transmembrane signaling receptor activity [GO:0004888] GPAKENSCAAIK 1 5.2 0.88766 -0.18592 0 0 0 0 0 8.93564 0 0 0 0 0 0 Q9NZS9 BFAR_HUMAN Bifunctional apoptosis regulator (EC 2.3.2.27) (RING finger protein 47) BFAR BAR RNF47 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630] ALGVKPPQNLWEYKAVNPGR;EPTWKQWR;KTECPECR;LLDLKEPTWK;MWSHFWK;TECPECR;TVPQRMWSHFWK 7 11.8 0.97574 -5.093 6.32738 0 0 0 0 0 8.01408 10.0088 0 13.0791 0 0 Q9NZT2 OGFR_HUMAN Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) OGFR Homo sapiens (Human) regulation of cell growth [GO:0001558] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] opioid growth factor receptor activity [GO:0140625] AQNYQKR;RFKPSSLPHPLEGSRK;RQLVHFAWEHFRPR 3 5.5 0.79073 0.0169 8.42597 0 0 0 0 6.58262 7.55566 8.43254 11.706 0 0 0 Q9NZU0 FLRT3_HUMAN Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3) FLRT3 KIAA1469 UNQ856/PRO1865 Homo sapiens (Human) axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560] axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone membrane [GO:0032584]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060] chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674] DDYAEAGTKK;LALPMTALR 2 2.9 0.93692 -0.56776 0 0 0 0 0 0 0 0 0 7.5772 0 0 Q9NZU1 FLRT1_HUMAN Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1) FLRT1 UNQ752/PRO1483 Homo sapiens (Human) cell adhesion [GO:0007155]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965] cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection terminus [GO:0044306]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; protein-macromolecule adaptor activity [GO:0030674] IADDTFSR;ITWKATLPASSFR;LYLQDNAISHIPYNTLAKMR 3 6.1 0.96185 -1.0752 0 0 0 0 0 8.42874 11.3967 0 0 0 0 0 Q9NZU5 LMCD1_HUMAN LIM and cysteine-rich domains protein 1 (Dyxin) LMCD1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; regulation of cardiac muscle hypertrophy [GO:0010611] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] LGLQYMELIPK;QPVTGTEGAFYRRR 2 6.8 0.95248 -0.67125 0 0 4.00603 0 0 0 0 0 0 0 0 0 Q9NZU7 CABP1_HUMAN Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) CABP1 Homo sapiens (Human) negative regulation of protein import into nucleus [GO:0042308]; visual perception [GO:0007601] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; enzyme inhibitor activity [GO:0004857]; nuclear localization sequence binding [GO:0008139] VLPQAHCRPR 1 2.7 0.92949 -0.48542 0 0 0 0 0 0 0 0 0 0 0 11.0804 Q9NZV1 CRIM1_HUMAN Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] CRIM1 S52 UNQ1886/PRO4330 Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] insulin-like growth factor receptor activity [GO:0005010]; PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867] ARCEVQFSPR;EDDCTFCQCVNGER;YLVAGDR 3 3 0.97612 -2.3355 0 0 0 0 0 0 0 0 0 0 0 11.2358 Q9NZV7 ZIM2_HUMAN Zinc finger imprinted 2 (Zinc finger protein 656) ZIM2 ZNF656 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] DLSLPVVAK;HDYVGERACQCCDCGR;YQPEDDNNSDVTSDDDMTRNRR 3 8.9 0.82566 -0.019838 0 0 0 0 0 0 0 0 0 0 6.02678 0 Q9NZW4 DSPP_HUMAN Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)] DSPP Homo sapiens (Human) biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; odontoblast differentiation [GO:0071895]; regulation of odontoblast differentiation [GO:1901329] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201] IITYFCIWAVAWAIPVPQSKPLER 1 1.8 0.70915 0.15634 0 0 0 0 9.80103 0 0 0 0 0 0 0 Q9NZW5 PALS2_HUMAN "Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)" PALS2 MPP6 VAM1 Homo sapiens (Human) protein-containing complex assembly [GO:0065003] cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] GEILQIVNR 1 1.7 0.90909 -0.31497 0 0 0 0 0 0 0 0 0 0 8.85081 0 Q9NZZ3 CHMP5_HUMAN Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; erythrocyte differentiation [GO:0030218]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of receptor recycling [GO:0001919]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] cadherin binding [GO:0045296] DGVLVDEFGLPQIPAS;LDAELVKYK 2 11.4 0.94587 -0.65252 0 0 0 0 0 0 0 0 0 0 8.99113 8.05458 Q9P015 RM15_HUMAN "Large ribosomal subunit protein uL15m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15)" MRPL15 HSPC145 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] MLCTRKDPR 1 3 0.82499 -0.021319 0 10.8513 0 0 0 0 0 0 0 0 0 0 Q9P021 CRIPT_HUMAN Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3) CRIPT HSPC139 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; establishment of protein localization [GO:0045184]; mRNA processing [GO:0006397]; protein localization to microtubule [GO:0035372]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; RNA splicing [GO:0008380] "cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; spliceosomal complex [GO:0005681]" microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110] ARFDPYGK;MVCEKCEK 2 15.8 0.98107 -1.6906 0 10.0125 10.7971 10.2589 0 9.41941 6.95548 0 0 0 0 0 Q9P032 NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) NDUFAF4 C6orf66 HRPAP20 HSPC125 My013 Homo sapiens (Human) defense response to virus [GO:0051607]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] calmodulin binding [GO:0005516] LPKDHHFDMINIK 1 7.4 0.92266 -0.44216 0 0 0 0 0 7.98965 0 0 0 0 0 0 Q9P035 HACD3_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1) HACD3 BIND1 PTPLAD1 Homo sapiens (Human) canonical NF-kappaB signal transduction [GO:0007249]; fatty acid elongation [GO:0030497]; JNK cascade [GO:0007254]; negative regulation of intracellular signal transduction [GO:1902532]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rac protein signal transduction [GO:0016601]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] RPLFLAPDFDRWLDESDAEMELR 1 6.4 0.92218 -0.44709 0 0 0 0 0 0 0 0 0 9.55059 0 0 Q9P055 JKAMP_HUMAN JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4) JKAMP C14orf100 JAMP CDA06 HSPC213 HSPC327 Homo sapiens (Human) ERAD pathway [GO:0036503]; response to unfolded protein [GO:0006986] endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase binding [GO:0031625] AVDIQPACLGLYCGK;IACGLGK 2 7.1 0.95489 -0.78813 11.7142 12.8965 0 0 0 8.67515 0 10.8238 0 0 0 0 Q9P086 MED11_HUMAN Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11) MED11 HSPC296 Homo sapiens (Human) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] ALEDIER;TCEQMLEN 2 12.8 0.95902 -1.0097 0 0 0 0 0 0 0 0 0 8.08167 0 0 Q9P0G3 KLK14_HUMAN Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) KLK14 KLKL6 Homo sapiens (Human) epidermis morphogenesis [GO:0048730]; fertilization [GO:0009566]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; seminal clot liquefaction [GO:0070684] extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] GQLQGLVSWGMER 1 4.9 0.78755 0.017417 0 0 0 0 7.6916 0 0 0 0 0 0 0 Q9P0J0 NDUAD_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) NDUFA13 GRIM19 CDA016 CGI-39 Homo sapiens (Human) aerobic respiration [GO:0009060]; cellular response to interferon-beta [GO:0035458]; cellular response to retinoic acid [GO:0071300]; extrinsic apoptotic signaling pathway [GO:0097191]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of protein catabolic process [GO:0045732]; protein insertion into mitochondrial inner membrane [GO:0045039]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex [GO:0098803]; respiratory chain complex I [GO:0045271] ATP binding [GO:0005524]; endopeptidase activator activity [GO:0061133] TLQMLRENLEEEAIIMK 1 11.8 0.81291 -0.010475 0 0 0 0 0 10.6163 0 0 0 0 0 0 Q9P0J1 PDP1_HUMAN "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)" PDP1 PDP PPM2C Homo sapiens (Human) peptidyl-threonine dephosphorylation [GO:0035970]; signal transduction [GO:0007165] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] ENWWQYTQGRRYASTPQK;MLSLPEELAR;YASTPQK 3 5.2 0.87858 -0.14008 0 0 0 0 0 0 0 0 0 8.66384 8.69234 0 Q9P0J6 RM36_HUMAN "Large ribosomal subunit protein bL36m (39S ribosomal protein L36, mitochondrial) (L36mt) (MRP-L36) (BRCA1-interacting protein 1)" MRPL36 BRIP1 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] structural constituent of ribosome [GO:0003735] MANLFIRKMVNPLLYLSR;SLLSPGLLPHLLPALGFKNKTVLK 2 40.8 0.74532 0.090917 0 0 0 4.86012 0 0 0 3.83076 0 0 0 0 Q9P0J7 KCMF1_HUMAN E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) KCMF1 FIGC ZZZ1 Homo sapiens (Human) negative regulation of HRI-mediated signaling [GO:0141191]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to oxidative stress [GO:0006979]; synaptic signaling [GO:0099536]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synapse [GO:0045202] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LNDPKMSETER 1 2.9 0.88564 -0.18086 0 0 11.9405 0 0 0 0 0 0 0 0 0 Q9P0K1 ADA22_HUMAN "Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)" ADAM22 MDC2 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222] DTWIQCNKR;EFMKYRR;IVLVAMETWATDNK;LASGECK;LNIEGTEKGNCGKDK;QLPQGDYVK;RFRPRSNSTETLSPAK;TRDRQCK;YIELMIVNDHLMFKKHR 9 11.1 0.91108 -0.32029 0 0 0 0 0 6.75822 0 0 0 0 6.38478 0 Q9P0K1 ADA22_HUMAN "Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)" ADAM22 MDC2 Homo sapiens (Human) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222] DTWIQCNKR;EFMKYRR;IVLVAMETWATDNK;LASGECK;LNIEGTEKGNCGKDK;NYREQRSNGLSHSWSER;RFRPRSNSTETLSPAK;TRDRQCK;YIELMIVNDHLMFKKHR 9 12.5 0.97607 -5.2452 10.1993 0 10.4418 0 10.6363 8.95274 0 0 8.68668 0 10.1888 10.9628 Q9P0K7 RAI14_HUMAN Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) RAI14 KIAA1334 NORPEG Homo sapiens (Human) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725] actin binding [GO:0003779] AEISSIR;VTEEEINVLK;YAESSSKLEEDKDK 3 3.2 0.9764 -2.2866 0 0 0 0 0 0 12.6964 10.7802 12.9693 0 0 12.2068 Q9P0K8 FOXJ2_HUMAN Forkhead box protein J2 (Fork head homologous X) FOXJ2 FHX Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell differentiation [GO:0110059]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LGSASQAGPPGSSR;NAGIGWKNSIR 2 4.4 0.98004 -2.0097 0 13.9067 0 0 0 0 0 0 11.8279 0 0 0 Q9P0K9 FRS1L_HUMAN DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein) FRRS1L C9orf4 Homo sapiens (Human) "regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synaptic transmission, glutamatergic [GO:0051966]" endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] dynein intermediate chain binding [GO:0045505]; protein-containing complex binding [GO:0044877] MGGDDVMACVHDDNGR 1 5.5 0.78397 0.024004 0 0 0 0 0 0 0 0 3.1508 0 0 0 Q9P0L0 VAPA_HUMAN Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) VAPA VAP33 Homo sapiens (Human) ceramide transport [GO:0035627]; cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; membrane fusion [GO:0061025]; negative regulation by host of viral genome replication [GO:0044828]; neuron projection development [GO:0031175]; phospholipid transport [GO:0015914]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein localization to endoplasmic reticulum [GO:0070972]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]; viral release from host cell [GO:0019076] azurophil granule membrane [GO:0035577]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; vesicle [GO:0031982] cadherin binding [GO:0045296]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495] ASASGAMAK;CVFEMPNENDK 2 8 0.94111 -0.60713 0 0 0 4.52913 0 0 0 0 0 0 0 5.98391 Q9P0L2 MARK1_HUMAN Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) MARK1 KIAA1477 MARK Homo sapiens (Human) cytoskeleton organization [GO:0007010]; establishment of mitochondrion localization [GO:0051654]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; neuron migration [GO:0001764]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of dendrite development [GO:0050773]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse assembly [GO:0150052]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] "3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]" KLLVLNPIKR;TTDRYVALQNGK 2 2.8 0.88922 -0.20722 0 0 0 9.35753 0 0 0 0 0 0 0 10.8506 Q9P0L9 PK2L1_HUMAN Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL TRPP3 Homo sapiens (Human) cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of chemical stimulus involved in sensory perception of taste [GO:0050912]; detection of mechanical stimulus [GO:0050982]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; response to water [GO:0009415]; sensory perception of sour taste [GO:0050915]; smoothened signaling pathway [GO:0007224]; sodium ion transmembrane transport [GO:0035725] actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] alpha-actinin binding [GO:0051393]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calcium-activated potassium channel activity [GO:0015269]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; pH-gated monoatomic ion channel activity [GO:0160128]; sodium channel activity [GO:0005272]; sour taste receptor activity [GO:0033040]; transmembrane transporter binding [GO:0044325] GTRVVFIDFSVYNANINLFCVLR 1 2.9 0.8855 -0.19409 0 0 0 0 10.574 0 0 0 0 0 0 0 Q9P0M2 AKA7G_HUMAN A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804]; regulation of protein kinase A signaling [GO:0010738] cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nucleotide binding [GO:0000166]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901] KKQSNGYYHCESSIVIGEK;NGVKKIDPDLYEK 2 9.2 0.88213 -0.1674 0 0 0 0 0 0 0 0 10.4972 7.94023 0 0 Q9P0M6 H2AW_HUMAN Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) MACROH2A2 H2AFY2 Homo sapiens (Human) "brain development [GO:0007420]; establishment of protein localization to chromatin [GO:0071169]; heterochromatin formation [GO:0031507]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of keratinocyte differentiation [GO:0045618]; sex-chromosome dosage compensation [GO:0007549]" "Barr body [GO:0001740]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]" chromatin DNA binding [GO:0031490]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527]; transcription cis-regulatory region binding [GO:0000976] AGVIFPVGR;FVIHCHIPQWGSDK;NCLSAAEDKK 3 8.9 0.91768 -0.42035 0 0 0 0 0 0 8.34296 0 0 0 0 0 Q9P0M9 RM27_HUMAN "Large ribosomal subunit protein bL27m (39S ribosomal protein L27, mitochondrial) (L27mt) (MRP-L27)" MRPL27 HSPC250 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] HFRWHPGAHVGVGKNK 1 10.8 0.84929 -0.077467 0 0 0 0 0 0 0 0 0 4.75066 0 0 Q9P0N9 TBCD7_HUMAN TBC1 domain family member 7 (Cell migration-inducing protein 23) TBC1D7 TBC7 HSPC239 Homo sapiens (Human) activation of GTPase activity [GO:0090630]; cellular response to starvation [GO:0009267]; negative regulation of cilium assembly [GO:1902018]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein ubiquitination [GO:0031398]; response to growth factor [GO:0070848] ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; TSC1-TSC2 complex [GO:0033596] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; TSC1-TSC2 complex binding [GO:0062078] ILVFVAVEILLTFKIK;LDTEKLCTFSQR 2 9.6 0.88586 -0.19401 0 0 10.4907 0 0 0 0 0 0 0 0 6.61549 Q9P0P0 RN181_HUMAN E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181) RNF181 HSPC238 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] TVVENLPR 1 5.2 0.93761 -0.56081 0 0 0 0 9.7447 0 0 0 0 0 0 0 Q9P0P8 MRES1_HUMAN Mitochondrial transcription rescue factor 1 MTRES1 C6orf203 HSPC230 Homo sapiens (Human) regulation of mitochondrial transcription [GO:1903108]; rescue of stalled ribosome [GO:0072344] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] EAGTETVMRILLK;LLAGVLR;LLAGVLRKPDAWIGLWGVLR;MAMASVK;SLQKVDEEDSDEESHHDEMSEQEEELEDDPTVVKNYK 5 32.1 0.94694 -0.66122 6.17756 0 0 7.99039 0 0 10.8376 8.11686 10.6343 0 0 0 Q9P0S9 TM14C_HUMAN Transmembrane protein 14C TMEM14C C6orf53 HSPC194 Homo sapiens (Human) erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; regulation of heme biosynthetic process [GO:0070453] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] VGVSMFNRPH 1 8.9 0.89645 -0.23651 0 0 0 0 0 7.48519 0 0 0 0 0 0 Q9P0U1 TOM7_HUMAN Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog) TOMM7 TOM7 TOMM07 AD-014 Homo sapiens (Human) positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of type 2 mitophagy [GO:1905091]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of protein stability [GO:0031647] mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] protein transmembrane transporter activity [GO:0008320] GADPGMPEPTVLSLLWG 1 30.9 0 8.6375 10.0542 10.0055 9.95146 0 0 0 8.87434 0 0 0 0 0 Q9P0U3 SENP1_HUMAN Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) SENP1 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]; regulation of mRNA stability [GO:0043488]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deSUMOylase activity [GO:0016929]; endopeptidase activity [GO:0004175]; SUMO-specific endopeptidase activity [GO:0070139] ELTSVYDSR;VPLEKEIPVTVVQETQKK 2 4.2 0.9806 -1.6628 0 0 0 0 0 0 0 11.7801 0 0 0 0 Q9P0U4 CXXC1_HUMAN CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) CXXC1 CFP1 CGBP PCCX1 PHF18 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] cis-regulatory region sequence-specific DNA binding [GO:0000987]; methylated histone binding [GO:0035064]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] DMKKFGGPNK;IYEILPQR;MCGECEACR;MEGDGSDPEPPDAGEDSK;RTEDCGHCDFCRDMK;TEDCGHCDFCR;TEDCGHCDFCRDMK;TEDCGHCDFCRDMKK;VPADEVCGCPLVR;YCSDDCGMK 10 12 0.975 -3.9948 0 0 8.3156 0 0 0 0 5.87752 5.74666 8.74457 4.5989 7.13062 Q9P0V3 SH3B4_HUMAN SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) SH3BP4 BOG25 EHB10 TTP Homo sapiens (Human) cellular response to amino acid stimulus [GO:0071230]; endocytosis [GO:0006897]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of GTPase activity [GO:0034260]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; protein localization to lysosome [GO:0061462]; regulation of catalytic activity [GO:0050790] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] KVTVGLYGPK;QNKNHYLLEYK;SPAPEQFQSR;VSAEIKNDLFSK 4 4.5 0.98052 -1.7971 12.6805 10.5643 0 0 0 0 0 0 13.9243 7.97039 0 0 Q9P0V8 SLAF8_HUMAN SLAM family member 8 (B-lymphocyte activator macrophage expressed) (BCM-like membrane protein) (CD antigen CD353) SLAMF8 BLAME Homo sapiens (Human) B-1 B cell lineage commitment [GO:0002336]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of dendritic cell chemotaxis [GO:2000509]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of neutrophil migration [GO:1902623]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; phagosome acidification [GO:0090383]; regulation of B cell differentiation [GO:0045577]; regulation of kinase activity [GO:0043549]; regulation of NAD(P)H oxidase activity [GO:0033860] cell surface [GO:0009986]; membrane [GO:0016020] identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] GSLETLYHSRFLGR 1 4.9 0.9174 -0.4074 0 0 0 0 0 0 0 10.753 0 0 0 0 Q9P0V9 SEP10_HUMAN Septin-10 SEPTIN10 SEPT10 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ARQYPWGVVQVENENHCDFVK;EEEMKQMFVQR;EESYQPIVDYIDAQFEAYLQEELK;SSSQANFIK 4 12.9 0.97762 -1.5173 0 10.1335 0 0 0 0 0 4.8711 0 0 0 0 Q9P0W0 IFNK_HUMAN Interferon kappa (IFN-kappa) IFNK UNQ6124/PRO20084 Homo sapiens (Human) adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of innate immune response [GO:0045089]; regulation of DNA-templated transcription [GO:0006355]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132] VPQLSSLELRRYFHR 1 7.2 0.45554 0.19133 0 0 8.94427 0 0 0 0 0 0 0 0 0 Q9P0W2 HM20B_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) HMG20B BRAF35 HMGX2 HMGXB2 SMARCE1R Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of neuron differentiation [GO:0045666]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; skeletal muscle cell differentiation [GO:0035914] chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] LEQELALEER 1 3.2 0.93571 -0.52823 0 0 0 0 0 0 0 10.6749 0 0 0 0 Q9P0W8 SPAT7_HUMAN Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3) SPATA7 HSD3 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226]; photoreceptor cell maintenance [GO:0045494]; protein localization to photoreceptor connecting cilium [GO:1903621]; protein localization to photoreceptor outer segment [GO:1903546]; visual perception [GO:0007601] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206]; rod photoreceptor outer segment [GO:0120200] ATSVLPR;ATSVLPRYGPPCLFK;EEMNGFSSFAR;HIKQNKHLEEEK;KELAQCEKEFK;TAMRANYK 6 9.5 0.97543 -2.3518 0 15.5395 0 8.77522 0 0 0 3.08332 5.60543 15.2626 7.49721 0 Q9P0X4 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3) CACNA1I KIAA1120 Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; neuronal action potential [GO:0019228]; signal transduction [GO:0007165]; sleep [GO:0030431] plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] DTLRDCTHDER;GDRGEDEEEIDYTLCFR;ILGVLRVLRLLR;LLRTLRPLRVISR;LLRVLKLVR;QALGPEAPAPAKPGPHAKEPR;SPSWAADRSK;SSWNSLK;TGSANPHK;VLRLLRTLRPLR 10 4.7 0.98113 -1.5927 6.76527 4.93494 7.24413 9.33653 9.45177 0 4.69326 9.79394 10.5326 8.0237 6.27852 9.94707 Q9P0Z9 SOX_HUMAN Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX LPIPOX PSO Homo sapiens (Human) L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; lysine catabolic process [GO:0006554] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115] LTPSYDLAPFRISR 1 3.6 0.91932 -0.43799 0 11.3756 0 0 0 0 0 0 0 0 0 0 Q9P104 DOK5_HUMAN Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6) DOK5 C20orf180 Homo sapiens (Human) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386] cytoplasm [GO:0005737]; cytosol [GO:0005829] LLQSVKNSMLQMKMSER 1 5.6 0.95808 -1.0139 0 0 0 0 0 10.7219 0 0 0 0 0 0 Q9P107 GMIP_HUMAN GEM-interacting protein (GMIP) GMIP Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] ASYELEFAK;ELLAWTEK;FLQELTEPVIPFHLYDAFISLAK;VAARFMENK 4 5.1 0.97485 -2.3815 11.096 0 0 0 0 0 0 0 0 0 0 10.6014 Q9P109 GCNT4_HUMAN "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)" GCNT4 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; inter-male aggressive behavior [GO:0002121]; kidney morphogenesis [GO:0060993]; neutrophil homeostasis [GO:0001780]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; thyroid hormone metabolic process [GO:0042403]; tissue morphogenesis [GO:0048729] Golgi membrane [GO:0000139] "acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]" LNGANMLETVKPPNSK;VFILFLTLWLLSLLKLLNVRR 2 8.2 0.37898 0.22118 0 0 0 0 0 5.38419 0 9.19798 0 0 0 0 Q9P121 NTRI_HUMAN Neurotrimin (hNT) (IgLON family member 2) NTM IGLON2 NT UNQ297/PRO337 Homo sapiens (Human) cell adhesion [GO:0007155]; neuron recognition [GO:0008038] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] AGCVWLLPLLVLHLLLKF;GVCGYLFLPWK;GVCGYLFLPWKCLVVVSLR;VKVTVNYPPYISEAKGTGVPVGQK 4 17.7 0.95535 -0.85898 14.9931 0 0 0 10.3995 0 0 6.43909 9.82555 0 0 11.0057 Q9P127 LUZP4_HUMAN Leucine zipper protein 4 (Cancer/testis antigen 28) (CT-28) (CT28) (Tumor antigen HOM-TES-85) LUZP4 Homo sapiens (Human) mRNA transport [GO:0051028] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] TIVKRNR 1 3 0.68458 0.1628 0 0 0 0 0 7.23295 0 0 0 0 0 0 Q9P1A2 PP4RL_HUMAN Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like PPP4R1L C20orf192 PRO1085 Homo sapiens (Human) LEKYAFSENTFNRQIIAR;LVSDPCR;MASMLSK;YAFSENTFNRQIIARGLLDIFR 4 9.4 0.97687 -2.2074 0 9.79782 0 0 0 6.44133 0 0 11.1377 0 0 0 Q9P1A2 PP4RL_HUMAN Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like PPP4R1L C20orf192 PRO1085 Homo sapiens (Human) LVSDPCR;MASMLSK;QIICKMASMLSK 3 7 0.8875 -0.18558 0 0 0 0 0 0 10.8773 0 0 0 0 0 Q9P1A6 DLGP2_HUMAN Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) DLGAP2 C8orf68 DAP2 ERICH1-AS1 Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804]; neuron-neuron synaptic transmission [GO:0007270] glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090] AMGDEESGESDSSPK;AQRMSPWPQDSRGLYNSTDSLDSNK;MMESPERK;SESPGRIRHLVHSVQK;SLDLPDRQR;VPPPIPK;VPPPIPKKPPK 7 8 0.97437 -3.5081 10.5856 9.66544 0 0 0 0 0 10.2803 2.93847 0 0 11.0723 Q9P1P5 TAAR2_HUMAN Trace amine-associated receptor 2 (TaR-2) (Trace amine receptor 2) (G-protein coupled receptor 58) TAAR2 GPR58 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] AVSSEQHELSHFKR 1 4 0.87563 -0.12878 0 0 0 0 0 0 0 0 0 0 0 10.2765 Q9P1Q0 VPS54_HUMAN Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) VPS54 HCC8 Homo sapiens (Human) "apoptotic DNA fragmentation [GO:0006309]; astrocyte differentiation [GO:0048708]; cellular response to progesterone stimulus [GO:0071393]; gene expression [GO:0010467]; Golgi to vacuole transport [GO:0006896]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; L-glutamate import [GO:0051938]; lysosomal transport [GO:0007041]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; musculoskeletal movement [GO:0050881]; negative regulation of motor neuron apoptotic process [GO:2000672]; neural tissue regeneration [GO:0097719]; neurofilament cytoskeleton organization [GO:0060052]; neuroinflammatory response [GO:0150076]; neuromuscular synaptic transmission [GO:0007274]; neuron projection morphogenesis [GO:0048812]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to cell surface [GO:0034394]; protein targeting to ER [GO:0045047]; protein targeting to lysosome [GO:0006622]; regulation of growth [GO:0040008]; respiratory electron transport chain [GO:0022904]; response to antibiotic [GO:0046677]; response to calcium ion [GO:0051592]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle tissue growth [GO:0048630]; spermatid differentiation [GO:0048515]; sphingolipid catabolic process [GO:0030149]; striated muscle contraction [GO:0006941]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; thrombin-activated receptor signaling pathway [GO:0070493]; ubiquitin recycling [GO:0010992]; vacuole organization [GO:0007033]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] syntaxin binding [GO:0019905] APVPSACFRNICK;GLKDLDLNMAEIWEQKR;LALTRNNCVK 3 4.1 0.92075 -0.43725 0 0 0 0 0 0 0 0 9.6903 0 9.31737 9.31465 Q9P1U1 ARP3B_HUMAN Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) ACTR3B ARP11 ARP4 Homo sapiens (Human) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062] actin binding [GO:0003779]; ATP binding [GO:0005524] AIKEKYCYICPDIVK;LSEELSGGR 2 5.7 0.50253 0.18856 0 0 0 0 0 0 0 0 0 4.28511 0 0 Q9P1V8 SAM15_HUMAN Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) SAMD15 C14orf174 FAM15A Homo sapiens (Human) signal transduction [GO:0007165] protein serine/threonine kinase activator activity [GO:0043539] LGESLEETDLQPPK 1 2.1 0.78673 0.01739 0 0 0 0 0 0 0 10.7181 0 0 0 0 Q9P1W3 CSC1_HUMAN Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C) TMEM63C C14orf171 CSC1 Homo sapiens (Human) glomerular filtration [GO:0003094]; monoatomic cation transport [GO:0006812] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] RLDLIFVTFQDSR;VMIRIHPCAR;VMIRIHPCARLCFCK 3 3.5 0.022514 0.61127 0 6.78254 0 0 8.60641 0 7.54689 10.1286 0 0 0 0 Q9P1W8 SIRPG_HUMAN Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) SIRPG SIRPB2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870] membrane [GO:0016020]; plasma membrane [GO:0005886] VGNQVNVTCQVR 1 3.1 0.93305 -0.49626 0 0 0 9.12583 0 0 0 0 0 0 0 0 Q9P1W8 SIRPG_HUMAN Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) SIRPG SIRPB2 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870] membrane [GO:0016020]; plasma membrane [GO:0005886] GPASSLTALLLIAVLLGPIYVPWK 1 8.7 0.70944 0.15634 0 0 3.70332 0 0 0 0 0 0 0 0 0 Q9P1W9 PIM2_HUMAN Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h) PIM2 Homo sapiens (Human) apoptotic mitochondrial changes [GO:0008637]; G1/S transition of mitotic cell cycle [GO:0000082]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of mitotic cell cycle [GO:0007346]; response to virus [GO:0009615] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LQVAIKVIPRNR;LTKPLQGPPAPPGTPTPPPGGK 2 10.9 0.76332 0.068213 0 0 0 0 9.54115 0 0 3.55606 0 0 0 0 Q9P1Y5 CAMP3_HUMAN Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) CAMSAP3 KIAA1543 Homo sapiens (Human) cilium movement [GO:0003341]; DNA replication checkpoint signaling [GO:0000076]; embryo development ending in birth or egg hatching [GO:0009792]; epithelial cell-cell adhesion [GO:0090136]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; in utero embryonic development [GO:0001701]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; protein transport along microtubule [GO:0098840]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of Golgi organization [GO:1903358]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]; replication fork arrest [GO:0043111]; zonula adherens maintenance [GO:0045218] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule minus-end [GO:0036449]; motile cilium [GO:0031514]; replication fork protection complex [GO:0031298]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] AQLKLMDDLDKVLRPR;IEAIFAKHR;LLFWVDTTVRRLQEK;TFLVPEIKSLDQYDFSR 4 4.6 0.98051 -1.813 5.31346 0 0 7.00113 9.14512 7.22834 0 0 0 0 0 0 Q9P1Y6 PHRF1_HUMAN PHD and RING finger domain-containing protein 1 PHRF1 KIAA1542 Homo sapiens (Human) protein ubiquitination [GO:0016567] membrane [GO:0016020] metal ion binding [GO:0046872]; RNA polymerase binding [GO:0070063] GPWGHSR;RDDGGGR;TLFKCICIR 3 1.4 0.96265 -1.0802 10.2036 0 0 0 0 0 10.5772 0 0 0 7.33503 0 Q9P1Z0 ZBTB4_HUMAN Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) ZBTB4 KIAA1538 Homo sapiens (Human) DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; methyl-CpNpG binding [GO:0010428]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" HEVWHTGERR;SYVTLSSLKRHSNVHSWR;VCKTAAALSRHGQR 3 4.1 0.97544 -2.3521 0 0 9.69307 0 0 0 8.89694 10.7907 0 0 0 0 Q9P1Z2 CACO1_HUMAN Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) CALCOCO1 KIAA1536 PP13275 UNQ2436/PRO4996 Homo sapiens (Human) nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DTVKALTR 1 1.2 0.9141 -0.33804 0 0 0 0 0 0 0 0 0 7.60874 0 0 Q9P1Z3 HCN3_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 HCN3 KIAA1535 Homo sapiens (Human) cellular response to dopamine [GO:1903351]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248] ATGDGSPGRK;FTKILSLLRLLR;ILSLLRLLRLSR;VKSAGAWIIHPYSDFR 4 5.3 0.96163 -1.0675 0 0 4.81404 0 0 2.49828 5.14889 4.74405 0 0 0 4.02024 Q9P1Z9 CC180_HUMAN Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) extracellular exosome [GO:0070062] ELDTYHVDCMMR;FEELLPQVCWLVMENFKEHHWKK;GGENRPPARVQSSSEELELR;HRWQGLVDTWK;LTESDEEMNR;QQSDKETLAFHLEK;YLASFEEELKR 7 5.9 0.95867 -1.0054 0 0 0 2.27241 0 0 0 16.8511 7.82585 0 15.4756 11.9447 Q9P202 WHRN_HUMAN Whirlin (Autosomal recessive deafness type 31 protein) WHRN DFNB31 KIAA1526 Homo sapiens (Human) auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; USH2 complex [GO:1990696] identical protein binding [GO:0042802] LLPMLRLVIPR;LPHARTTVDETK;SFLNILHDEAVRLLK 3 4.2 0.96515 -1.1615 0 0 0 0 6.7226 8.30634 0 5.33964 0 0 0 0 Q9P203 BTBD7_HUMAN BTB/POZ domain-containing protein 7 BTBD7 KIAA1525 Homo sapiens (Human) morphogenesis of a branching epithelium [GO:0061138]; regulation of branching involved in salivary gland morphogenesis [GO:0060693] nucleus [GO:0005634] SPFFRNLLQR;TAPKAGPPPVYLPSVK 2 2.3 0.94278 -0.62242 0 0 0 0 0 0 0 8.30392 0 0 6.30761 0 Q9P206 NHSL3_HUMAN NHS-like protein 3 NHSL3 KIAA1522 Homo sapiens (Human) cell differentiation [GO:0030154] EDVGAPLVTPSLLQMVRLR;LPALLGLFKKK;NLVAELRSISEQRPPQAPKK;SLQHQEK 4 5.5 0.97488 -3.0897 0 0 0 0 0 0 5.39493 10.2973 0 9.10407 8.93065 0 Q9P212 PLCE1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" PLCE1 KIAA1516 PLCE PPLC Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerulus development [GO:0032835]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of lamellipodium assembly [GO:0010592]; Ras protein signal transduction [GO:0007265]; release of sequestered calcium ion into cytosol [GO:0051209] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; small GTPase binding [GO:0031267] IIPLKALKR;ISVGPCLK;NDREVKK;NLNINCNNILR;RMEENSSGNTMSASSMFNTEER;SLETDEEDSPSEGNSSR;SLKDAMAQHESSCEYRK;STLLVRRFCK;VGQNGLK;VGQNGLKNSEKESTVNSIFQVIR;VMEPPSTVEIRQDGSQR 11 6.1 0.97994 -1.8349 4.0697 14.327 7.60659 9.03746 10.3254 10.5791 0 9.22757 9.68454 0 8.67804 0 Q9P212 PLCE1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" PLCE1 KIAA1516 PLCE PPLC Homo sapiens (Human) calcium-mediated signaling [GO:0019722]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerulus development [GO:0032835]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of lamellipodium assembly [GO:0010592]; Ras protein signal transduction [GO:0007265]; release of sequestered calcium ion into cytosol [GO:0051209] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; small GTPase binding [GO:0031267] IIPLKALKR;ISVGPCLK;IWHQAWFLCSLLGR;RMEENSSGNTMSASSMFNTEER;SLETDEEDSPSEGNSSR;SLKDAMAQHESSCEYRK;VGQNGLK;VGQNGLKNSEKESTVNSIFQVIR 8 5.5 0.87503 -0.12717 0 0 0 0 10.9471 0 0 0 0 0 0 12.2776 Q9P215 POGK_HUMAN Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] ITAMLGVLADGRK;LVTYQRSVLALR;VAEYVRYMQAKGDPITR 3 6.9 0.86323 -0.083722 0 2.86461 0 0 0 0 0 11.2664 0 0 8.63735 0 Q9P217 ZSWM5_HUMAN Zinc finger SWIM domain-containing protein 5 ZSWIM5 KIAA1511 Homo sapiens (Human) Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular space [GO:0005615] zinc ion binding [GO:0008270] LSLDYPQR;MADGGER;TILEAIQKHIHSSSLIFK;VAISFDRCK;VEERFERIPEPVQR 5 4.7 0.98076 -1.7414 0 10.539 10.8475 0 9.88915 0 11.169 0 0 0 0 12.095 Q9P219 DAPLE_HUMAN Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) CCDC88C DAPLE KIAA1509 Homo sapiens (Human) "apical constriction [GO:0003383]; cilium organization [GO:0044782]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule bundle formation [GO:0001578]; mucociliary clearance [GO:0120197]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of JNK cascade [GO:0046330]; protein destabilization [GO:0031648]; respiratory basal cell differentiation [GO:1902691]; small GTPase-mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical junction complex [GO:0043296]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] dynein light intermediate chain binding [GO:0051959]; frizzled binding [GO:0005109]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983] ALVKLIKPK;ALVKLIKPKK;AMWSLRER;AMWSLRERSQVSSEAR;DLTKQVTVHAR;ESRALDKELAR;KEGSRER;LHDLELDRDTDK;LIDQRDECTELIVDLTQER;LLEKEAK;LNALRRHK;LSQELEK;LSQLEFEKR;LWQQVELK;QNQGEGQHLQNSFKHPAGKTAASHQGK;TLTTLREDLVLEK;TLTTLREDLVLEKLK;VRQELEDKTEQLVDTR;VTSLETATEK 19 9.5 0.97828 -8.5928 3.14465 8.11155 13.3849 11.9996 0 10.8371 12.5486 9.88885 11.1286 11.6696 11.3909 7.66612 Q9P225 DYH2_HUMAN Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) DNAH2 DNAHC2 DNHD3 KIAA1503 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] DGVWVRGLYLEGAGWDR;DWEENWNEWK;FYFLSNDDLLEILGQSRNPEAVQPHLKK;GPAGTGK;IIWVNSPHYNTRER;IRMNAALAQLREK;KIQTQISSGMTNNASLLQNYLK;MLIVRSLR;QLPNESTLFDQVNSNWK;QYDEKLAQK;SLCMWVR;SSYLAPFMK;TLFERHK;VAFCVTSFIITNLGSR;VGGPSSK 15 4.3 0.97685 -4.7545 13.7726 0 6.15346 0 8.66747 9.81465 8.71973 10.392 0 9.55723 6.73863 10.6761 Q9P227 RHG23_HUMAN Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) ARHGAP23 KIAA1501 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062] GTPase activator activity [GO:0005096] EEENGGR;GGGPSPR;HVFRLTTADFCEYLFQAEDR;IPSLRMLR;LPEPLFTDDKYNDFIEANR;SIPEPPPICYPR;SIPEPPPICYPRK 7 5 0.95537 -0.93389 0 10.5215 8.12381 8.79828 9.30088 10.4239 4.72993 11.7859 0 0 6.28259 10.8941 Q9P232 CNTN3_HUMAN Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein) CNTN3 KIAA1496 PANG Homo sapiens (Human) cell adhesion [GO:0007155] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] EAKLQFAYLENFK;ITSMDAR;LSNGHLLGYEVR;RFVSQETGHLYISK;SDGVMGEYEPK;VVASAPDFSKNPMK 6 6.9 0.97301 -2.5706 0 9.65868 0 7.06856 7.18368 9.71426 0 0 0 10.5987 0 0 Q9P241 AT10D_HUMAN Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) ATP10D ATPVD KIAA1487 Homo sapiens (Human) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287] FRGFLEHSNKER;LSNMILYFFYK;TLEFALQESLQK;TTKYTLLNFVPR 4 3.3 0.98048 -2.0171 0 0 0 0 0 0 10.5923 11.7425 0 0 10.6264 0 Q9P242 NYAP2_HUMAN Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 NYAP2 KIAA1486 Homo sapiens (Human) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] ENDRLRNETNLAYLK;KEDDDQSEAVYEEMK;LPVLENVSYMK;NETNLAYLK;QPPPKPK 5 7.4 0.93674 -0.543 12.0095 0 0 8.29829 0 0 0 0 0 11.3527 0 4.70614 Q9P243 ZFAT_HUMAN Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CCNLFSPNQSELLSHVSEK;EALDELCLMTREGK;LLHTADGKQFK 3 3.5 0.97948 -2.0444 0 0 0 0 0 0 0 0 0 9.48416 0 0 Q9P244 LRFN1_HUMAN Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) LRFN1 KIAA1484 SALM2 Homo sapiens (Human) regulation of postsynaptic density assembly [GO:0099151] cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787] RVVELRLTDNFIAAVR 1 2.1 0.47884 0.19052 0 0 0 0 4.1491 0 0 0 0 0 0 0 Q9P246 STIM2_HUMAN Stromal interaction molecule 2 STIM2 KIAA1482 Homo sapiens (Human) activation of store-operated calcium channel activity [GO:0032237]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of calcium ion transport [GO:0051928]; store-operated calcium entry [GO:0002115] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; store-operated calcium channel activity [GO:0015279] DEVAASYLIQAEK;HITIEDLWK;QWEVPDTASECDSLNSSIGR 3 5 0.015444 0.74544 0 15.3896 0 0 0 13.072 0 0 0 14.6238 0 0 Q9P253 VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog (hVPS18) VPS18 KIAA1475 Homo sapiens (Human) autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; protein ubiquitination [GO:0016567]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; symbiont entry into host cell [GO:0046718]; vesicle docking involved in exocytosis [GO:0006904] actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793] actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] AVFRYHVQR;EAICSSLK;VHYDLKYALRLCAEHGHHR;YHVQREAR 4 4 0.95453 -0.95225 9.78423 0 0 0 8.27529 0 9.9335 0 0 0 9.33009 0 Q9P255 ZN492_HUMAN Zinc finger protein 492 (Zinc finger protein 115) ZNF492 KIAA1473 ZNF115 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFKQSSTLTTHKR;AFSRFSHLTTHK;VIHTGEKPYKYEECGK 3 7.7 0.95176 -0.703 0 8.21014 0 0 0 7.34527 0 0 0 8.36164 0 0 Q9P258 RCC2_HUMAN Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) RCC2 KIAA1470 TD60 Homo sapiens (Human) cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027] "chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]" guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] IEYDCELVPRR;LEGSKCK;QQAAYRNLGQNLWGPHRYGCLAGVR;SSTAAQEVK 4 10 0.95866 -1.0048 0 7.73877 0 8.23304 7.31089 7.26838 0 0 0 0 0 0 Q9P260 RELCH_HUMAN "RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats)" RELCH KIAA1468 Homo sapiens (Human) intracellular cholesterol transport [GO:0032367] recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] CLRTDMEHLSPEHEVILSSMIKECEQK;KTVHFDKPNR;VGPNAEPR 3 3.7 0.886 -0.19642 0 0 0 0 0 0 0 7.92065 8.83403 7.21878 0 0 Q9P265 DIP2B_HUMAN Disco-interacting protein 2 homolog B (DIP2 homolog B) DIP2B KIAA1463 Homo sapiens (Human) negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; positive regulation of peptidyl-lysine acetylation [GO:2000758] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perikaryon [GO:0043204] alpha-tubulin binding [GO:0043014] AVSTTFGSR;DLHWAMMAHRDQR;EGSVMGVTVSR;IQQLLNTLKRPKRPPLK;TCVVVAEERPR 5 3.9 0.98112 -1.5924 0 0 0 0 0 0 0 0 9.66651 0 0 8.54264 Q9P266 JCAD_HUMAN Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) JCAD KIAA1462 Homo sapiens (Human) cell adhesion [GO:0007155]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748] adherens junction [GO:0005912]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] EVSSVSR;EVSSVSRMRVLSFR;LGHSLSVSK 3 1.7 0.95241 -0.67168 0 0 10.875 0 0 0 0 7.61868 0 0 0 0 Q9P267 MBD5_HUMAN Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) MBD5 KIAA1461 Homo sapiens (Human) glucose homeostasis [GO:0042593]; nervous system development [GO:0007399]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; regulation of behavior [GO:0050795]; regulation of multicellular organism growth [GO:0040014] chromocenter [GO:0010369]; chromosome [GO:0005694]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] GLTSWPGK;IEASPQRSR;TAEDVKADEDVTK 3 2 0.97331 -2.4931 0 0 0 0 0 0 8.94825 0 0 0 11.066 0 Q9P270 SLAI2_HUMAN SLAIN motif-containing protein 2 SLAIN2 KIAA1458 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] LEKQNEQLR;LSLQGHPTDLQTSNVK 2 4.3 0.9413 -0.59258 0 0 12.421 0 0 0 0 6.01972 0 7.38172 0 0 Q9P272 TRM9B_HUMAN Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-) TRMT9B C8orf79 KIAA1456 TRM9L Homo sapiens (Human) tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; nucleus [GO:0005634] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175] GHPYHPPCSECSCSVCFK;SWFFSRSLDESTLR 2 7 0.90824 -0.27744 0 0 0 0 7.86251 0 0 0 0 7.05398 0 0 Q9P273 TEN3_HUMAN Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) TENM3 KIAA1455 ODZ3 TNM3 Homo sapiens (Human) camera-type eye morphogenesis [GO:0048593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron development [GO:0048666]; positive regulation of neuron projection development [GO:0010976]; regulation of homophilic cell adhesion [GO:1903385]; signal transduction [GO:0007165] axon [GO:0030424]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AIQEIPPGIFWR;DNEGDGLIDCMDPDCCLQSSCQNQPYCR;EADEFTRQGQNFTLR;LSEILYDSTR;WFPASPNLAYTFIWDK 5 3 0.93327 -0.49589 13.3247 12.8363 0 0 0 12.714 0 7.91666 0 13.8606 0 0 Q9P275 UBP36_HUMAN Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) USP36 KIAA1453 Homo sapiens (Human) chromatin organization [GO:0006325]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of mitophagy [GO:1901524]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; histone H2B deubiquitinase activity [GO:0140936]; K48-linked deubiquitinase activity [GO:1990380]; RNA binding [GO:0003723]; transferase activity [GO:0016740] HSCSPMGDGDPEAMEESPR;LPQHIREATAAPHGKR;NIGNGIISSPLTGKR;RFANFSGGK 4 5.3 0.91798 -0.40499 0 0 3.44069 8.28049 0 0 0 7.34323 0 0 0 8.94471 Q9P278 FNIP2_HUMAN Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) FNIP2 FNIPL KIAA1450 MAPO1 Homo sapiens (Human) intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TORC1 signaling [GO:1904263]; protein phosphorylation [GO:0006468]; regulation of protein phosphorylation [GO:0001932] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765] ATPase inhibitor activity [GO:0042030]; protein-folding chaperone binding [GO:0051087] AVQKIEEVTAQKTEDVPIK;GEVEESEYVVITVR;IAESSLR;KMEERVK;LQEMYLK;NQLCQRFLK 6 5.7 0.97674 -4.8235 13.7686 0 0 8.81433 0 0 10.5963 8.69296 12.4533 0 0 0 Q9P281 BAHC1_HUMAN BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2) BAHCC1 BAHD2 KIAA1447 Homo sapiens (Human) chromatin binding [GO:0003682] AERVEAEK;CLYPGNVVR;GPGRPRK;LDTQEVGMRVR;SKGSGPHAHAQR 5 1.8 0.97336 -2.4909 0 0 0 10.3682 8.40778 0 0 10.8878 0 7.09814 0 0 Q9P283 SEM5B_HUMAN Semaphorin-5B SEMA5B KIAA1445 SEMAG UNQ5867/PRO34001 Homo sapiens (Human) axon extension [GO:0048675]; axon guidance [GO:0007411]; detection of light stimulus involved in visual perception [GO:0050908]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215] ALSTASR;CTDDGAQSR;EPLRSLR;FLLEDTWTTFMK;VARVCKNDVGGR 5 4.1 0.96219 -1.0689 0 0 4.6659 0 0 6.9438 0 10.9791 10.6704 8.49857 7.46377 0 Q9P287 BCCIP_HUMAN BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) BCCIP TOK1 Homo sapiens (Human) DNA repair [GO:0006281]; establishment of mitotic spindle orientation [GO:0000132]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; neuroendocrine cell differentiation [GO:0061101]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] kinase regulator activity [GO:0019207]; RNA binding [GO:0003723]; tubulin binding [GO:0015631] MNEIMDKLK;TFVEAGK;TVMLIPGDKMNEIMDK 3 8 0.95467 -0.79808 0 0 0 0 0 4.42102 0 0 0 9.7034 9.82375 7.57304 Q9P289 STK26_HUMAN Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) STK26 MASK MST4 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; intracellular signal transduction [GO:0035556]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981] apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vesicle membrane [GO:0012506] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AEGHSDDESDSEGSDSESTSR;CSADESP 2 6.7 0.882 -0.16305 5.86136 0 0 0 6.31703 0 0 0 0 3.5579 0 0 Q9P291 ARMX1_HUMAN Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) ARMCX1 ALEX1 AD032 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] AGGRASGK;LAWGRDENEK 2 4 0.96433 -1.1786 0 0 0 0 10.1334 0 0 0 0 0 0 0 Q9P2A4 ABI3_HUMAN ABI gene family member 3 (New molecule including SH3) (Nesh) ABI3 NESH Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; defense response to tumor cell [GO:0002357]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of ruffle assembly [GO:1900028]; neuron migration [GO:0001764]; positive regulation of cellular senescence [GO:2000774]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynaptic density assembly [GO:0099151] actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209] actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] DLSTQLSR;VSTLGQMVNMHMEK 2 6 0.91578 -0.36611 4.73042 0 0 0 0 5.23274 0 0 0 0 0 11.077 Q9P2B2 FPRP_HUMAN Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315) PTGFRN CD9P1 EWIF FPRP KIAA1436 Homo sapiens (Human) lipid droplet organization [GO:0034389]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] LENWTDASRVDGVVLEK;NVQPSDQGHYK 2 3.2 0.96679 -1.2652 0 0 0 0 0 0 0 0 10.8252 0 0 0 Q9P2B4 CT2NL_HUMAN CTTNBP2 N-terminal-like protein CTTNBP2NL KIAA1433 Homo sapiens (Human) negative regulation of transmembrane transport [GO:0034763]; negative regulation of transporter activity [GO:0032410]; protein dephosphorylation [GO:0006470]; protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; FAR/SIN/STRIPAK complex [GO:0090443]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] protein phosphatase 2A binding [GO:0051721] HKQLSSMLVLECK;TLKEEMESLK 2 3.6 0.94396 -0.62746 0 7.12247 0 0 0 0 0 0 0 0 9.38591 0 Q9P2B7 CFA97_HUMAN Cilia- and flagella-associated protein 97 CFAP97 KIAA1430 Homo sapiens (Human) spermatogenesis [GO:0007283] EGEDDYYTDGEESSDDGK 1 3.4 0.68682 0.16372 0 0 0 0 0 0 3.54905 0 0 0 0 0 Q9P2C4 TM181_HUMAN Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) membrane [GO:0016020] toxic substance binding [GO:0015643] ETSIKTSFPMTVK;LAPMRLYTLSK;VDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELR;VFFMVVAAVYILYLLFLIVR 4 11.6 0.97921 -2.0462 0 0 0 0 0 7.32841 0 0 0 10.1333 0 0 Q9P2D0 IBTK_HUMAN Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) negative regulation of protein phosphorylation [GO:0001933]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654] protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292] GIENSQAPK;KGVLDWLIQKGVDLLVK;SVDGKEFPCHK;TIMEIEESRQK 4 3.5 0.97574 -2.3165 0 0 0 5.10257 0 9.67161 11.909 0 0 0 0 10.0532 Q9P2D1 CHD7_HUMAN Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7) CHD7 KIAA1416 Homo sapiens (Human) adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; limb development [GO:0060173]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518] AKTATPKPK;GEEKGNENEDENK;LQAILKPMMLRR;QEALMKTDRR;QSGFVPESMFDR;VGMPDAK;YKNFSYLHCQWASIEDLEK 7 2.7 0.97489 -4.1172 0 13.977 13.9096 0 11.0159 11.3679 12.0397 11.8376 12.0857 0 0 12.5422 Q9P2D3 HTR5B_HUMAN HEAT repeat-containing protein 5B HEATR5B KIAA1414 p200 p200a Homo sapiens (Human) "endocytosis [GO:0006897]; protein localization [GO:0008104]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471] AAQDYLQEK;AAQDYLQEKR;ASAAMVR;GSSSQLYRESATTMEKLAVLK;LAAAWCLR;NTLRCMTILPTILFLIARILK;SIVTLSMAK 7 3.8 0.9747 -3.1998 0 3.55262 0 0 0 0 6.7451 13.3689 0 8.77456 0 0 Q9P2D7 DYH1_HUMAN Dynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7) DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; extracellular region [GO:0005576]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AAEIQAKVR;ALFVSFLEESISFVR;GVRANLLK;KIEIERR;LLQVITQTLQDLLKALK;LPPLLKPYEEHFK;LREVEDGIATMQAKYR;LVIEAVCIMKGIKPKK;LYLVHKTDEK;MVKEFQPYLDLWTTASDWLR;VAMRSSLR;VHRDFRLWLTSLPSNK;VTAMSLFHSSLSK 13 3.9 0.97853 -8.9089 14.3773 0 0 0 0 9.29306 10.2181 0 0 12.6092 4.57453 3.72203 Q9P2D7 DYH1_HUMAN Dynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7) DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; extracellular region [GO:0005576]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] KIEIERR;LYLVHKTDEK;MTVISPIPGVMRPRG;MVKEFQPYLDLWTTASDWLR;VAMRSSLR;VTAMSLFHSSLSK 6 6.1 0.58744 0.17923 0 0 0 0 0 6.79546 0 0 0 0 0 0 Q9P2D8 UNC79_HUMAN Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) plasma membrane [GO:0005886] FYLSRSVVLELLQALK;VPEDAENPTESEKPDTSAESDTEQNPER 2 1.7 0.72668 0.12449 0 0 0 7.99215 5.81337 0 0 0 0 0 0 0 Q9P2E2 KIF17_HUMAN Kinesin-like protein KIF17 (KIF3-related motor protein) KIF17 KIAA1405 KIF3X Homo sapiens (Human) anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cell projection organization [GO:0030030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; postsynapse [GO:0098794] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] DALLREYQEEIKK;ELRCQPVVTVDCAR;EYQEEIKK;LLEKMQR;LSSTVAR;TQVSSRFAELPK;YADERRK 7 5.8 0.97493 -3.0798 0 0 0 7.1536 11.3264 10.8282 12.5648 0 0 15.4948 0 0 Q9P2E3 ZNFX1_HUMAN NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048] cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380] helicase activity [GO:0004386]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] CQEPCIGECPPCQR;LGYKFLESLLQK;NIVECNSHVKEPR;WQLYRLWLQLYQADTR;YQGEENDIILLSLVRSNQEGK 5 4 0.97857 -1.5304 12.194 0 0 0 11.518 0 0 5.24933 0 10.0441 0 0 Q9P2E5 CHPF2_HUMAN Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) CHPF2 CHSY3 CSGLCAT KIAA1402 UNQ299/PRO339 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] GAPIGGRFDR;LDQSDEDFKPR;LLNGYRRFDPAR;LSNLEGLGGR;TVAHHFPRLLYFTGQR 5 7.6 0.98102 -1.735 0 0 0 9.80935 9.68059 9.98911 0 11.9046 0 0 0 5.26337 Q9P2E5 CHPF2_HUMAN Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) CHPF2 CHSY3 CSGLCAT KIAA1402 UNQ299/PRO339 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] LDQSDEDFKPR;LLNGYRRFDPAR;QDGGQIENCCCIF;TVAHHFPRLLYFTGQR 4 7.8 0.7105 0.15781 0 0 0 0 0 0 0 0 0 0 6.28531 0 Q9P2E7 PCD10_HUMAN Protocadherin-10 PCDH10 KIAA1400 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] EKKLNIYTCLASDCCLCCCCCGGGGSTCCGR;KLNIYTCLASDCCLCCCCCGGGGSTCCGRQAR 2 3.3 0.96696 -1.3003 0 0 0 0 0 0 0 0 0 4.25957 0 0 Q9P2E8 MARH4_HUMAN E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4) MARCHF4 KIAA1399 MARCH4 RNF174 Homo sapiens (Human) protein ubiquitination [GO:0016567] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; trans-Golgi network [GO:0005802] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GCWSCELCYYK;VLNYDKTK 2 4.6 0.80605 0.0119 0 7.23525 0 0 0 0 0 0 0 0 0 0 Q9P2E9 RRBP1_HUMAN Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) RRBP1 KIAA1398 Homo sapiens (Human) osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; translation [GO:0006412] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; ribosome [GO:0005840] RNA binding [GO:0003723]; signaling receptor activity [GO:0038023] AAAGEAK;AAILETAPK;AENSQLTER;DLQKSVEEEEQVWRAK;EKKLTSDLGR;EMAKTHHQK;ESEEALQK;ETSYEEALANQRK;EVQQLQGK;GEGAQNQGKK;KAEGAQNQGQK;LLATEQEDAAVAK;LQSSEAEVR;NTDVAQSPEAPK;SRVTVKHLEEIVEK;SVEEEEQVWR;TTQEQLAR;VEGITNQGK 18 13.1 0.97456 -3.7656 9.16536 12.8532 10.9465 9.02564 0 10.6768 9.97671 9.5167 10.7314 7.37591 10.2897 0 Q9P2F5 STOX2_HUMAN Storkhead-box protein 2 STOX2 KIAA1392 Homo sapiens (Human) embryo development ending in birth or egg hatching [GO:0009792]; maternal placenta development [GO:0001893]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] ESLASNTSSIVESNR;HTLNTLVRERK;LEEEKAQR;NHCDSCHCCR;SEKDYRLHK 5 5.7 0.98054 -1.6484 12.3936 0 0 5.63799 10.0712 10.9569 0 0 11.5421 8.85643 9.03395 10.7239 Q9P2F6 RHG20_HUMAN Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] EAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTK;GPRTHRR;TLAERRR 3 3.9 0.95953 -1.0438 0 0 0 0 6.88594 0 0 0 0 0 7.85518 0 Q9P2F8 SI1L2_HUMAN Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) SIPA1L2 KIAA1389 Homo sapiens (Human) presynaptic signal transduction [GO:0098928]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978] GTPase activator activity [GO:0005096] DFLLAKVINAENAAHKSEK;KFSFYGNLSPR;LSHIGDK 3 2.1 0.95559 -0.9884 0 0 0 0 0 0 0 12.0177 0 0 11.7657 11.4462 Q9P2F8 SI1L2_HUMAN Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) SIPA1L2 KIAA1389 Homo sapiens (Human) presynaptic signal transduction [GO:0098928]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978] GTPase activator activity [GO:0005096] KFSFYGNLSPR;LCSIVTRGCETVEMTLR;LSHIGDK 3 4.5 0.88559 -0.18216 0 0 0 0 9.24503 0 0 0 0 0 0 0 Q9P2F9 ZN319_HUMAN Zinc finger protein 319 ZNF319 KIAA1388 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FKYASDLQRHR;RTHSSERPYKCAVCEK 2 4.6 0.78545 0.024888 0 0 0 0 0 8.8099 8.51637 0 0 0 0 9.53477 Q9P2G1 AKIB1_HUMAN Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) ANKIB1 KIAA1386 Homo sapiens (Human) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ILKCSYPYGFFLEPK;NHEHSYQLEQRLLKTAK;QEFLASVARGVAPADSPEAPRR;WKGAKLDQGEYER;YDFCWICLEEWK 5 7.3 0.91292 -0.38795 0 7.16098 0 10.1918 10.0249 11.0375 13.2871 13.0614 13.9435 13.7929 13.6739 0 Q9P2G3 KLH14_HUMAN Kelch-like protein 14 (Protein interactor of Torsin-1A) (Printor) (Protein interactor of torsinA) KLHL14 KIAA1384 Homo sapiens (Human) actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025] EFSNNTM 1 1.8 0.9159 -0.33274 0 0 0 0 0 0 0 0 0 7.94977 0 0 Q9P2G4 MAP10_HUMAN Microtubule-associated protein 10 (Microtubule regulator of 120 KDa) MAP10 KIAA1383 MTR120 Homo sapiens (Human) cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431] microtubule binding [GO:0008017] DKRSVGGCEK;SSILSPPFSAGSPVHSYR;YLDSDASFTENSDTSR 3 4.9 0.82974 -0.024354 0 0 7.70058 0 9.93418 0 0 0 0 0 8.47151 0 Q9P2G9 KLHL8_HUMAN Kelch-like protein 8 KLHL8 KIAA1378 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ASMNTKR;AVPDFEYSIR;QNLKCRDLLDEAR;WLLANPQHHSK 4 6.6 0.98077 -2.0226 0 0 0 8.13894 9.80442 0 0 0 7.69342 0 0 0 Q9P2H0 CE126_HUMAN Centrosomal protein of 126 kDa CEP126 KIAA1377 Homo sapiens (Human) cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; non-motile cilium assembly [GO:1905515] centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; midbody [GO:0030496] LIIPCPPPQSTSNIR;QIQESNLKSEVNLPFSR;SEVNLPFSRRPTINWR 3 3.5 0.96163 -1.0726 0 0 0 9.27163 0 0 0 0 8.8351 0 0 12.112 Q9P2H3 IFT80_HUMAN Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) IFT80 KIAA1374 WDR56 Homo sapiens (Human) apoptotic process [GO:0006915]; articular cartilage development [GO:0061975]; bone mineralization involved in bone maturation [GO:0035630]; canonical NF-kappaB signal transduction [GO:0007249]; cartilage homeostasis [GO:1990079]; cilium assembly [GO:0060271]; endochondral ossification [GO:0001958]; establishment or maintenance of cell polarity [GO:0007163]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; growth plate cartilage chondrocyte differentiation [GO:0003418]; intraciliary anterograde transport [GO:0035720]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; non-canonical Wnt signaling pathway [GO:0035567]; non-motile cilium assembly [GO:1905515]; odontoblast differentiation [GO:0071895]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; proteasomal protein catabolic process [GO:0010498]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; receptor localization to non-motile cilium [GO:0097500]; response to inositol [GO:1902140]; smoothened signaling pathway [GO:0007224]; spinal cord development [GO:0021510]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; tooth eruption [GO:0044691] 9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992] DLCITSVK;ILKEEWSR;LLEQLTDTHWTDLTHLIEKLKEQK;QKFLETFGKQETNK;YLHYAEGLQIDWEKIKAK 5 6.7 0.97704 -2.2227 6.46985 0 12.1662 0 9.65263 0 0 12.095 0 8.64245 0 0 Q9P2H5 UBP35_HUMAN Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) USP35 KIAA1372 USP34 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] CVPDGPHRLLFCQQLVRCLGR;DLHVPNEDRIK;EKEEEVEEEEEK;LLARHPRCVPDGPHR;VEKETEK;WIIALLKGLAAVKK;YYCESCASLQDAEK 7 8.4 0.97967 -1.8787 0 0 11.8895 0 6.9814 0 8.66299 0 0 6.58895 5.03316 0 Q9P2I0 CPSF2_HUMAN Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) CPSF2 CPSF100 KIAA1367 Homo sapiens (Human) mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794] RNA binding [GO:0003723] DLFIQWCQDPKNSIILTYR;ELEEYLEK;ELEEYLEKEK;TETGRIGLEGCLCQDFYR 4 6 0.97099 -1.3455 0 0 0 8.68923 5.6239 0 0 0 0 13.0513 13.1083 0 Q9P2J2 TUTLA_HUMAN Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) IGSF9 IGSF9A KIAA1355 NRT1 Homo sapiens (Human) axon guidance [GO:0007411]; dendrite development [GO:0016358]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse maturation [GO:0090128] axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] cell-cell adhesion mediator activity [GO:0098632] RLRQDPPLIFSPTGK 1 1.3 0.44659 0.19201 0 0 0 0 0 0 0 0 9.04524 0 0 0 Q9P2J5 SYLC_HUMAN "Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)" LARS1 KIAA1352 LARS Homo sapiens (Human) cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glutaminyl-tRNA aminoacylation [GO:0006425]; leucyl-tRNA aminoacylation [GO:0006429]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell size [GO:0008361]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear body [GO:0016604] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; GTPase activator activity [GO:0005096]; leucine-tRNA ligase activity [GO:0004823] CCLFPFGLHCTGMPIKACADK;ENLEKMGPRILDLQLEFDEK;FDDPLLGPR;FSADGMR;IQSQNDREKLAEAK;LSGLKGK;SLGLSDEEIVK;VFEVNASNLEK 8 8.5 0.97754 -2.1345 0 0 0 9.49464 11.6567 0 0 0 9.01173 0 9.97742 11.1098 Q9P2J8 ZN624_HUMAN Zinc finger protein 624 ZNF624 KIAA1349 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CQTQEENFTENLNLITDTHLGK;IICKEMK;TNSDFTVHLR 3 4.5 0.98054 -1.666 0 0 0 8.95675 0 0 6.85012 0 0 0 0 0 Q9P2J9 PDP2_HUMAN "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2)" PDP2 KIAA1348 Homo sapiens (Human) response to starvation [GO:0042594]; signal transduction [GO:0007165]; T-helper cell differentiation [GO:0042093] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; metal ion binding [GO:0046872] DVTSVHLDHLR;TIIMEDRLLGVLIPCR 2 5.1 0.96327 -1.0848 0 0 0 0 0 0 0 0 10.9511 0 0 0 Q9P2K1 C2D2A_HUMAN Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; kidney development [GO:0001822]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224] ciliary transition zone [GO:0035869]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; MKS complex [GO:0036038] IDIPPVLLGYSKER;INFDVTRPK;LAQLYDQYLARHQR;RPLRPRRK;VTAQNLSDGDIK;YLQQVRESVINRFLIAK 6 4.6 0.97335 -2.6363 12.3529 0 10.0233 0 0 0 8.52939 0 0 0 10.5923 0 Q9P2K2 TXD16_HUMAN Thioredoxin domain-containing protein 16 TXNDC16 ERP90 KIAA1344 Homo sapiens (Human) endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062] ANIIFSYVRAIGIPEHR;GTSTMLLTR;GTSTMLLTRINCADWSDVCTK;HWNRSNWFKEAEK;LLGKAGVLLLLR;QKYLDSFTPCWLNLK;SNWFKEAEKSFR 7 9.8 0.97557 -3.3415 0 9.66057 0 5.16491 0 9.71598 0 9.2436 9.0983 0 10.0819 0 Q9P2K3 RCOR3_HUMAN REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] SANGSAK;VGAEYQAR 2 3.4 0.95144 -0.70623 0 0 0 0 0 0 0 0 0 0 0 10.9751 Q9P2K5 MYEF2_HUMAN Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) MYEF2 KIAA1341 Homo sapiens (Human) myotube differentiation [GO:0014902]; neuron differentiation [GO:0030182] nucleus [GO:0005634] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] NLPFDLTWQKLK 1 2 0.9808 -1.598 0 0 0 0 0 0 9.58141 0 0 0 0 0 Q9P2K6 KLH42_HUMAN Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) KLHL42 KIAA1340 KLHDC5 Homo sapiens (Human) cell division [GO:0051301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of microtubule-based process [GO:0032886] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; spindle [GO:0005819] LEDRCYPVSKR;LIEQSDYFRALYRSGMR 2 5.5 0.97857 -2.0909 0 0 0 0 0 0 0 0 9.19059 0 10.3677 0 Q9P2K8 E2AK4_HUMAN eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) adaptive immune response [GO:0002250]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; GCN2-mediated signaling [GO:0140469]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tRNA binding [GO:0000049] ANSSGRSR;GAPGRGR;KCVCLDDKER;KLGIKLQVLINLGLVYK;LDGCCYAVKR;LGIKLQVLINLGLVYK;QERLEIASLSNQDHTSK;QTEKRVLETELVDHVLQK;YETQVQTR;YYNAWIER 10 6.2 0.97711 -5.7333 0 9.56799 0 0 5.81844 9.16486 6.21269 12.2544 8.69523 10.2448 10.5631 8.51846 Q9P2K9 DISP3_HUMAN Protein dispatched homolog 3 (Patched domain-containing protein 2) DISP3 KIAA1337 PTCHD2 Homo sapiens (Human) cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of lipid metabolic process [GO:0045834]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of lipid transport [GO:0032368]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] AYVSANTQTHAHWRIELIFLAR;DLADFTSETLQR;GASRWDYSR;LVTIHEIERK;VIPAASLGGPGPYR 5 4.8 0.97962 -1.8246 0 11.5354 6.57036 10.7341 0 0 0 11.3428 10.9732 0 8.17787 0 Q9P2L0 WDR35_HUMAN WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog) WDR35 IFT121 KIAA1336 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991] DPEHPNKDYLINFEIRSLR;IALAVDSFIYFANIRPNYK;LQCVSWNK;SLETLSSEQK;SVLLDEILKDPEHPNK 5 5.5 0.98052 -1.6795 0 0 0 10.4505 0 7.60392 0 8.77568 0 0 0 12.2193 Q9P2M1 LR2BP_HUMAN LRP2-binding protein (Megalin-binding protein) (MegBP) LRP2BP KIAA1325 Homo sapiens (Human) cytoplasm [GO:0005737] GVKRSNEEAER;HLKFAAAYNLGRAYYEGK 2 8.4 0.96761 -1.3053 0 0 0 0 0 0 0 0 0 0 10.0074 0 Q9P2M4 TBC14_HUMAN TBC1 domain family member 14 TBC1D14 KIAA1322 Homo sapiens (Human) autophagy [GO:0006914]; negative regulation of autophagy [GO:0010507]; recycling endosome to Golgi transport [GO:0071955]; regulation of autophagosome assembly [GO:2000785] autophagosome [GO:0005776]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901] EQSVRKSSTFPR;SLPLDLACR 2 3 0.76761 0.058635 0 0 0 0 0 0 11.346 0 0 0 0 0 Q9P2M7 CING_HUMAN Cingulin CGN KIAA1319 Homo sapiens (Human) microtubule cytoskeleton organization [GO:0000226] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017] ALEARLEEAQR;DTEQLRRSMQDATQDHAVLEAER;ELEEQNLQLQK;ELEETSEETGHWQSMFQKNKEDLR;GLEEKVSR;LDKELLAQR;LETELDEEK;LGQEQQTLNRALEEEGK;TVDRLNK 9 9.9 0.97606 -2.3365 12.0005 12.7734 8.37282 8.64479 5.83648 7.32562 12.0905 12.0959 8.393 9.22395 9.46044 9.79479 Q9P2N2 RHG28_HUMAN Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) ARHGAP28 KIAA1314 Homo sapiens (Human) negative regulation of stress fiber assembly [GO:0051497]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096] AKDILAKFQYENSHGSSECIK;EELDAKFNADK;QSIRDVR;VIANESK;VLQKSPSAR;VPLVLQK 6 8.5 0.53063 0.18665 0 0 0 0 0 0 0 8.33673 0 0 0 0 Q9P2N2 RHG28_HUMAN Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) ARHGAP28 KIAA1314 Homo sapiens (Human) negative regulation of stress fiber assembly [GO:0051497]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096] EELDAKFNADK;FQYENRILHWQRAALSFLNGK;QSIRDVR;VIANESK;VLQKSPSAR;VPLVLQK 6 9.3 0.97486 -3.8556 0 0 0 0 5.89217 0 12.0357 0 0 8.51897 0 9.90076 Q9P2N4 ATS9_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) aorta morphogenesis [GO:0035909]; camera-type eye morphogenesis [GO:0048593]; cornea development in camera-type eye [GO:0061303]; endothelial cell-matrix adhesion [GO:0090673]; extracellular matrix organization [GO:0030198]; heart valve morphogenesis [GO:0003179]; lens development in camera-type eye [GO:0002088]; melanocyte differentiation [GO:0030318]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; ventricular cardiac muscle tissue development [GO:0003229]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] AEEWQECTKTCGEGSRYR;ALDWSSCSVTCGQGR;LLKIFCAGMHSDHPK;QAGCDHVLNSKARR;TCGGGIKTAIR;VAGNTAYYQLRDR 6 4.4 0.97606 -5.2252 0 0 0 0 8.59444 7.89421 0 0 12.6036 0 7.31061 0 Q9P2N5 RBM27_HUMAN RNA-binding protein 27 (RNA-binding motif protein 27) RBM27 KIAA1311 Homo sapiens (Human) cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] IPQELNNITK 1 0.9 0.89471 -0.24333 0 0 0 0 8.19599 0 0 0 0 0 0 0 Q9P2N6 KANL3_HUMAN KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) KANSL3 KIAA1310 NSL3 PRTD SI1 Homo sapiens (Human) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial transcription [GO:1903108] histone acetyltransferase complex [GO:0000123]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654] ALQSDRLAR;DVARRDLAFEVPER;LMLTHHLFWTGWTMAQNKLFNK;QALASVSWDTK 4 7.3 0.98072 -1.7943 0 0 0 0 0 10.0959 0 0 0 0 0 0 Q9P2P1 NYNRI_HUMAN Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Protein cousin of GIN1) NYNRIN CGIN1 KIAA1305 Homo sapiens (Human) DNA integration [GO:0015074]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261] cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]; RNA-DNA hybrid ribonuclease activity [GO:0004523] APAAPKVPVTPRVSR;DYCRSCLFCIPR;GIWEAEVTR;GLCSPELWKEVR;GQGQAGR;KITTYDYRFMVK;SCLFCIPR;TSPAGPK;VIESPWPLR 9 4.4 0.97536 -4.1059 0 12.5358 8.22246 11.8021 0 11.0951 11.866 11.8955 12.8716 9.20765 0 4.03448 Q9P2P5 HECW2_HUMAN "E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)" HECW2 KIAA1301 NEDL2 Homo sapiens (Human) protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686] ubiquitin protein ligase activity [GO:0061630] GYGQGPGK;RDTHHFERYQHNR;SMGASPK;YSFFALLTDVLEIEIKDK 4 2.9 0.9589 -1.0356 0 0 0 9.92809 0 3.54893 0 0 0 0 8.72445 8.16752 Q9P2P6 STAR9_HUMAN StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9) STARD9 KIAA1300 Homo sapiens (Human) microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225] centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ALEEQCDEDHQTPR;ALLLSFELR;DLFIWDLDLPSRR;DLPVHNKFSNWCGVQK;DVNREFR;EAEETAQK;EGGRIIVEVDGK;ICEGLFVREK;IHQKIISQLLK;ISASTSPQDHGK;ISASTSPQDHGKDLR;LEGVSDFFSTSEK;LKALLLSFELR;LTSCSSLSPQR;MANVQVAVRVRPLSKR;RLEKLTTLCWLQDDSTQEPPYQVLSPDATVPRPPCR;SQRLGNSFVPEK 17 4.4 0.97805 -7.0919 3.09189 0 3.66391 10.2119 7.23026 5.16185 4.76102 10.8476 9.0043 10.0225 11.56 4.5831 Q9P2Q2 FRM4A_HUMAN FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) establishment of epithelial cell polarity [GO:0090162]; negative regulation of protein secretion [GO:0050709]; positive regulation of protein secretion [GO:0050714] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein-macromolecule adaptor activity [GO:0030674] ELLDLVASHFNLK;FSVEVHDPR;QEALEETLRQR;SPHYVHSTR 4 4 0.97576 -1.4623 0 0 0 0 0 0 0 0 11.8154 11.1636 0 0 Q9P2R3 ANFY1_HUMAN Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) ANKFY1 ANKHZN KIAA1255 Homo sapiens (Human) "endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020] metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] EPPWCDGSYCYECTAR;LANRFQLQLLR 2 2.3 0.97567 -1.471 0 0 0 0 3.9457 9.41107 0 0 0 0 0 0 Q9P2R6 RERE_HUMAN Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) RERE ARG ARP ATN1L KIAA0458 Homo sapiens (Human) branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942] histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] DKARESENSRPR;HCFTTTSKDWHHGGR;LVKKPVPKLIEK;RDHLLMNVKWYYR;VDSFFYILGYNPETRR;VGPSHQAK 6 4.9 0.97329 -2.8901 10.3589 0 6.07086 7.17163 0 0 0 0 0 6.80012 8.85854 0 Q9P2R7 SUCB1_HUMAN "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" SUCLA2 Homo sapiens (Human) succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775] ALIADSGLK;GRICNQVLVCERK;IVFSPEEAK;LGSKDVVIK 4 8.6 0.97534 -3.3607 0 0 10.3078 0 0 0 0 0 0 10.6389 0 0 Q9P2S2 NRX2A_HUMAN Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha) NRXN2 KIAA0921 Homo sapiens (Human) adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of postsynapse assembly [GO:0150052]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625] cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991] calcium channel regulator activity [GO:0005246]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888] DGFQGCLASVDLNGR;EGDPKMK;EMQVASDLFVGGIPPDVRLSALTLSTVK;FNDNAWHDVR;LGRVVDEWLLDK;LNDNEWHTVR;VNDGEWCHVDFQRDGR;WRPTPPPLLLLLLLALAAR 8 6.8 0.97203 -2.7171 6.18761 10.3524 10.3238 11.4777 12.4347 11.5499 0 0 8.34722 6.96763 4.20516 11.8154 Q9P2S5 WRP73_HUMAN WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) WRAP73 WDR8 Homo sapiens (Human) cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; MWP complex [GO:1990811] IGIGMLAFSPDSYFLATR;ILLYSLDGR 2 5.9 0.73569 0.11024 0 0 0 0 0 0 2.06381 0 0 0 0 9.08353 Q9P2S6 ANKY1_HUMAN Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc finger MYND domain-containing protein 13) ANKMY1 TSAL1 ZMYND13 Homo sapiens (Human) metal ion binding [GO:0046872] EQLSMEMILKAEEGNHEWICR 1 2.2 0.82767 -0.021489 0 0 0 7.33423 0 0 0 0 0 0 0 0 Q9P2T0 SPMA2_HUMAN Sperm microtubule associated protein 2 (Cancer/testis antigen 56) (CT56) (Testicular haploid expressed gene protein) SPMAP2 THEG Homo sapiens (Human) cell differentiation [GO:0030154]; chaperone-mediated protein complex assembly [GO:0051131]; spermatogenesis [GO:0007283] nucleus [GO:0005634] MGDSRRR;VEELSRPK 2 4 0.9328 -0.51372 0 0 0 0 0 0 0 10.3488 8.91298 0 0 0 Q9P2T1 GMPR2_HUMAN GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Homo sapiens (Human) GMP metabolic process [GO:0046037]; purine nucleobase metabolic process [GO:0006144] cytosol [GO:0005829]; GMP reductase complex [GO:1902560] GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872] DILGGIR 1 2 0.80729 0.0075685 0 0 0 0 0 0 0 0 0 6.48588 0 0 Q9P2W1 HOP2_HUMAN Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein) PSMC3IP HOP2 TBPIP Homo sapiens (Human) homologous chromosome pairing at meiosis [GO:0007129]; meiotic joint molecule formation [GO:0000709]; meiotic strand invasion involved in reciprocal meiotic recombination [GO:0010774]; reciprocal meiotic recombination [GO:0007131] condensed nuclear chromosome [GO:0000794]; DNA recombinase auxiliary factor complex [GO:0120231]; nucleoplasm [GO:0005654] double-stranded DNA binding [GO:0003690]; nuclear receptor coactivator activity [GO:0030374]; recombinase activator activity [GO:0120230] YCKEWRK 1 3.2 0.82913 -0.024608 0 0 0 0 0 0 7.20359 0 0 0 0 0 Q9P2W7 B3GA1_HUMAN "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)" B3GAT1 GLCATP Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; protein glycosylation [GO:0006486]; visual learning [GO:0008542] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872] GNEEPWVQPALEMPKR 1 4.6 0.53937 0.1853 0 0 0 0 0 6.78555 0 0 0 0 0 0 Q9P2Y4 ZN219_HUMAN Zinc finger protein 219 ZNF219 Homo sapiens (Human) limb bud formation [GO:0060174]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histamine receptor activity [GO:0004969]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALLREAR;ALLREARLGR;GRRPPQADASPPYAR;SFRSAHHLK 4 4.7 0.97398 -3.0341 0 0 0 0 0 0 9.04267 6.36513 0 0 0 11.7458 Q9P2Y5 UVRAG_HUMAN UV radiation resistance-associated gene protein (p63) UVRAG Homo sapiens (Human) "autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; multivesicular body sorting pathway [GO:0071985]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of autophagosome maturation [GO:1901098]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; symbiont entry into host cell [GO:0046718]" "autophagosome membrane [GO:0000421]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosome [GO:0005764]; lytic vacuole [GO:0000323]; midbody [GO:0030496]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]" SH3 domain binding [GO:0017124]; SNARE binding [GO:0000149] EFPLYPK 1 1 0.91722 -0.42406 0 0 0 0 0 0 0 0 0 0 9.24124 0 Q9P2Z0 THA10_HUMAN THAP domain-containing protein 10 THAP10 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] MPARCVAAHCGNTTK 1 5.8 0.266 0.26509 0 0 0 0 0 0 0 0 0 0 8.3122 0 Q9UBB4 ATX10_HUMAN Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) ATXN10 SCA10 Homo sapiens (Human) cell division [GO:0051301]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LIGNLCYKNKDNQDK;NKDNQDK 2 3.2 0.97519 -2.3574 0 0 0 9.7402 0 0 0 0 0 0 0 0 Q9UBB5 MBD2_HUMAN Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) cellular response to organic cyclic compound [GO:0071407]; chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; ventricular cardiac muscle tissue development [GO:0003229]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991] C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197] AADTEEMDIEMDSGDEA;YLGNTVDLSSFDFRTGK 2 8.3 0.90613 -0.27302 0 0 0 0 0 0 6.76235 0 0 0 6.37671 0 Q9UBB9 TFP11_HUMAN Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) TFIP11 STIP HSPC006 Homo sapiens (Human) "biomineral tissue development [GO:0031214]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of protein-containing complex assembly [GO:0031333]; protection from non-homologous end joining at telomere [GO:0031848]; RNA processing [GO:0006396]; spliceosomal complex disassembly [GO:0000390]" "catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]" nucleic acid binding [GO:0003676] GFAGGTK;HNVPDDGLPLQSQQLPQSGK;IFETLQDK;LILQPWK;VIDMTGREQK 5 6.2 0.97462 -2.3911 0 11.0767 9.43546 10.4007 10.1192 0 0 0 0 0 0 0 Q9UBC1 IKBL1_HUMAN NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) NFKBIL1 IKBL Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription regulator inhibitor activity [GO:0140416] SQIETWELGR 1 2.6 0.80453 0.013003 0 6.96509 0 0 0 0 0 0 0 0 0 0 Q9UBC3 DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) DNMT3B Homo sapiens (Human) methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628] catalytic complex [GO:1902494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]" HEGNIKYVNDVRNITK;LYPAIPAAR;REVSSLLSYTQSLRR 3 5.8 0.93685 -0.54914 0 0 8.98282 0 0 7.45648 0 5.09187 0 0 0 0 Q9UBC5 MYO1A_HUMAN Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) MYO1A MYHL Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; microvillus assembly [GO:0030033]; sensory perception of sound [GO:0007605]; vesicle localization [GO:0051648] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] SQILISSWFRGNMQKK;VVTALNVMQAQYAR 2 2.9 0.89626 -0.24131 0 0 0 0 0 0 0 0 7.60607 0 9.64618 0 Q9UBD0 HSFX1_HUMAN "Heat shock transcription factor, X-linked" HSFX1 LW-1; HSFX2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VGVKSAPR 1 1.9 0.91321 -0.33804 0 0 0 0 8.68177 0 0 0 0 0 0 0 Q9UBD3 XCL2_HUMAN Cytokine SCM-1 beta (C motif chemokine 2) (XC chemokine ligand 2) XCL2 SCYC2 Homo sapiens (Human) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood circulation [GO:0008015]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] IKTYTITEGSLR;TCVSLTTQRLPVSRIK 2 22.8 0.89653 -0.24805 8.07211 0 0 0 0 0 0 0 0 0 0 9.62266 Q9UBD5 ORC3_HUMAN Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) ORC3 LATHEO ORC3L Homo sapiens (Human) DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; glial cell proliferation [GO:0014009]; neural precursor cell proliferation [GO:0061351]; regulation of DNA replication [GO:0006275] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication preinitiation complex [GO:0031261]; nuclear body [GO:0016604]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" DNA replication origin binding [GO:0003688] CLHKFTSSLPK;ISLPIEDYFNK;NLFDNLIEFLQKSHSGFQK 3 5.8 0.96477 -1.2097 0 0 11.0661 0 9.08036 0 3.25061 0 0 0 0 8.15558 Q9UBE0 SAE1_HUMAN "SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]" SAE1 AOS1 SUA1 UBLE1A Homo sapiens (Human) positive regulation of protein sumoylation [GO:0033235]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510] ATP-dependent protein binding [GO:0043008]; enzyme activator activity [GO:0008047]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; ubiquitin activating enzyme activity [GO:0004839] LRASRVLLVGLK 1 3.5 0.30271 0.25002 0 0 9.87134 0 0 0 0 0 0 0 0 0 Q9UBE8 NLK_HUMAN Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) NLK LAK1 Homo sapiens (Human) "cellular response to osmotic stress [GO:0071470]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; JUN kinase activity [GO:0004705]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH2 domain binding [GO:0042169]; ubiquitin protein ligase binding [GO:0031625] CCFSTSTGR;ELKMLCFFK;TACEGAK;YHTCMCKCCFSTSTGR 4 6.1 0.98037 -1.7134 0 0 8.1637 0 0 0 0 5.62702 10.1358 0 0 0 Q9UBF2 COPG2_HUMAN Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) COPG2 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] ALCRITDGTMLQAIER;LLKETEDGHESPLFDFIESCLR;SAVLQEAR;SIATLAITTLLK 4 6.7 0.95686 -1.0237 0 0 0 0 0 0 0 0 0 10.3864 0 0 Q9UBF8 PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) PI4KB PIK4CB Homo sapiens (Human) inner ear development [GO:0048839]; lysosome organization [GO:0007040]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum membrane [GO:0030867] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524] ACQEVLEKVKLLHGGVAVSSR;TQRLISELSLLNHK 2 4.3 0.87285 -0.1122 0 5.41227 0 0 0 0 0 0 0 0 8.47058 0 Q9UBF9 MYOTI_HUMAN Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein) MYOT TTID Homo sapiens (Human) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; muscle contraction [GO:0006936]; synapse organization [GO:0050808] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018] actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; axon guidance receptor activity [GO:0008046]; structural constituent of muscle [GO:0008307] FCRMDFKVSGLPAPDVSWYLNGR;LECQISAIPPPK 2 7 0.9105 -0.32609 0 0 10.6786 0 0 0 0 0 5.67505 0 0 0 Q9UBG7 RBPJL_HUMAN Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L) RBPJL RBPL RBPSUHL Homo sapiens (Human) signal transduction [GO:0007165] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ILHAKVAQK;VSLFNRLRSQTVSTR 2 4.6 0.97288 -2.5024 0 0 0 0 8.88423 0 0 8.8364 0 0 0 0 Q9UBH6 S53A1_HUMAN Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1) XPR1 SLC53A1 SYG1 X3 Homo sapiens (Human) cellular response to phosphate starvation [GO:0016036]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; response to virus [GO:0009615] plasma membrane [GO:0005886] efflux transmembrane transporter activity [GO:0015562]; inositol hexakisphosphate binding [GO:0000822]; phosphate transmembrane transporter activity [GO:0005315]; virus receptor activity [GO:0001618] FATLQNELQSSLDAQKESTGVTTLR 1 3.6 0.83892 -0.039211 0 0 7.27585 0 0 0 0 0 0 0 0 0 Q9UBI6 GBG12_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 GNG12 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] G-protein beta-subunit binding [GO:0031681]; PDZ domain binding [GO:0030165] TASTNNIAQAR 1 15.3 0.93661 -0.55248 0 0 0 0 0 0 0 0 0 0 8.81263 0 Q9UBI9 HDC_HUMAN Headcase protein homolog (hHDC) HECA HDC Homo sapiens (Human) negative regulation of mitotic cell cycle [GO:0045930]; respiratory tube development [GO:0030323] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] GPSHDLPRRHSMDR;MPNPKNSK 2 4.1 0.96694 -1.2913 0 0 8.59444 0 9.73909 0 0 0 0 0 0 0 Q9UBJ2 ABCD2_HUMAN ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR) ABCD2 ALD1 ALDL1 ALDR ALDRP Homo sapiens (Human) fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; response to bacterium [GO:0009617]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AACLVAAAYALK;IVKSIVEK;LVAEEAHR 3 3.8 0.98042 -1.8062 0 0 0 0 0 0 10.9704 0 0 12.3977 0 0 Q9UBK2 PRGC1_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) PPARGC1A LEM6 PGC1 PGC1A PPARGC1 Homo sapiens (Human) adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cellular respiration [GO:0045333]; cellular response to oxidative stress [GO:0034599]; circadian regulation of gene expression [GO:0032922]; digestion [GO:0007586]; energy homeostasis [GO:0097009]; fatty acid oxidation [GO:0019395]; gluconeogenesis [GO:0006094]; intracellular glucose homeostasis [GO:0001678]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of smooth muscle cell proliferation [GO:0048662]; neuron apoptotic process [GO:0051402]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; respiratory electron transport chain [GO:0022904]; response to dietary excess [GO:0002021]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; temperature homeostasis [GO:0001659]; transcription initiation at RNA polymerase II promoter [GO:0006367] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625] AKSICQQQKPQR;ANQDNPFRASPKLK;RPCSELLK;SCYYYESSHYR;SFSRHRSCSR;YDSYEEYQHER 6 8.3 0.97513 -4.0325 0 0 0 9.7161 0 0 10.4693 0 5.66144 0 0 0 Q9UBK8 MTRR_HUMAN Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase) MTRR Homo sapiens (Human) cobalamin metabolic process [GO:0009235]; folic acid metabolic process [GO:0046655]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; negative regulation of cystathionine beta-synthase activity [GO:1904042]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654] "[methionine synthase] reductase (NADPH) activity [GO:0030586]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]" DVHDALVQIISKEVGVEK;LEAMKTLATLKEEK;SELLHIESQVELLRFDDSGR 3 7.4 0.9556 -0.87602 0 0 0 0 8.0232 0 0 0 6.32504 0 0 0 Q9UBK9 UXT_HUMAN Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein) UXT HSPC024 Homo sapiens (Human) apoptotic process [GO:0006915]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; spindle pole [GO:0000922] beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; microtubule binding [GO:0008017]; transcription corepressor activity [GO:0003714] VLDHRDKVYEQLAK 1 8.9 0.88136 -0.15297 0 0 0 0 0 0 0 0 0 0 0 11.625 Q9UBL0 ARP21_HUMAN cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) ARPP21 TARPP Homo sapiens (Human) cytoplasm [GO:0005737] calmodulin binding [GO:0005516]; nucleic acid binding [GO:0003676] SKSGAGK;TSGSRQSSSENELK 2 2.6 0.90996 -0.28249 0 0 0 10.7378 10.6685 0 8.3975 8.7936 0 10.8466 0 0 Q9UBL3 ASH2L_HUMAN Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) ASH2L ASH2L1 Homo sapiens (Human) DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815] euchromatin [GO:0000791]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] DIIPFIDKYWECMTTR 1 2.5 0.91654 -0.42673 9.44979 0 8.75104 0 0 0 0 0 0 0 0 0 Q9UBL6 CPNE7_HUMAN Copine-7 (Copine VII) CPNE7 Homo sapiens (Human) cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] LDDKDLFSKSDPFLELYR 1 2.8 0.96305 -1.0821 0 0 0 0 0 10.5662 0 0 0 0 0 0 Q9UBL9 P2RX2_HUMAN P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) P2RX2 P2X2 Homo sapiens (Human) behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; sensory perception of sound [GO:0007605]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; urinary bladder smooth muscle contraction [GO:0014832] apical plasma membrane [GO:0016324]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; purinergic nucleotide receptor activity [GO:0001614] FAKYYKINGTTTR;FHFSKGNIADR;LGFIVEKAGESFTELAHK 3 8.9 0.94088 -0.59015 0 0 0 0 0 9.92199 0 12.2914 0 10.4167 8.19879 12.139 Q9UBL9 P2RX2_HUMAN P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) P2RX2 P2X2 Homo sapiens (Human) behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; sensory perception of sound [GO:0007605]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; urinary bladder smooth muscle contraction [GO:0014832] apical plasma membrane [GO:0016324]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; purinergic nucleotide receptor activity [GO:0001614] FAKYYKINGTTTR;GEGWGELHR;VPEALHVPRGLRPLLPHLQAGLYR 3 12.4 0.93371 -0.50245 0 0 0 0 0 0 0 0 0 5.4491 10.549 0 Q9UBM4 OPT_HUMAN Opticin (Oculoglycan) OPTC OPT Homo sapiens (Human) angiogenesis [GO:0001525]; articular cartilage development [GO:0061975]; bone development [GO:0060348]; collagen fibril organization [GO:0030199]; negative regulation of angiogenesis [GO:0016525] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201] FNRISRIR;REEQMPREGDSFEVLPLR 2 7.8 0.98072 -1.5976 0 9.18502 8.75342 7.40761 0 0 0 0 0 0 0 0 Q9UBM7 DHCR7_HUMAN "7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2)" DHCR7 D7SR Homo sapiens (Human) cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; positive regulation of ferroptosis [GO:0160020] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640] 7-dehydrocholesterol reductase activity [GO:0047598]; NADP binding [GO:0050661] IGKWFDFK;SQPNIPK;VIECSYTSADGQRHHSK 3 6.7 0.97655 -1.489 0 0 0 0 10.6651 0 9.77146 0 0 11.3524 0 0 Q9UBM8 MGT4C_HUMAN "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Homo sapiens (Human) protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] Golgi membrane [GO:0000139] "acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]" FKPSLFQHMGYYSSYKGTENK 1 4.4 0.9211 -0.43896 0 7.90442 8.53656 0 0 0 9.90332 0 0 0 0 0 Q9UBN4 TRPC4_HUMAN Short transient receptor potential channel 4 (TrpC4) (Trp-related protein 4) (hTrp-4) (hTrp4) TRPC4 Homo sapiens (Human) calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; gamma-aminobutyric acid secretion [GO:0014051]; oligodendrocyte differentiation [GO:0048709]; regulation of cytosolic calcium ion concentration [GO:0051480] basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; caveola [GO:0005901]; cell surface [GO:0009986]; cortical cytoskeleton [GO:0030863]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" GDYASVK;KEVVGAVELLLNHK;MAQFYYKR;RYVAAMIR;SEKVVVEDTVPIIPK;WYDEFPGWR;WYDEFPGWRR 7 6.3 0.98025 -1.8649 0 0 0 0 0 0 0 8.81631 0 10.6286 0 10.3417 Q9UBN6 TR10D_HUMAN Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264) TNFRSF10D DCR2 TRAILR4 TRUNDD UNQ251/PRO288 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888] ILKFVVFIVAVLLPVR;ILKFVVFIVAVLLPVRVDSATIPR;NSPEMCRTCR;RRLLVPVNDADSADISTLLDASATLEEGHAK;SLKEEECPAGSHR;SSCTTTRDTVCQCEKGSFQDK;VSNCTPR 7 27.5 0.97377 -2.465 0 0 0 7.77023 0 0 3.18352 9.71471 0 6.59231 0 8.07419 Q9UBN7 HDAC6_HUMAN Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) HDAC6 KIAA0901 JM21 Homo sapiens (Human) "actin filament organization [GO:0007015]; aggresome assembly [GO:0070842]; axonal transport of mitochondrion [GO:0019896]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to topologically incorrect protein [GO:0035967]; cilium assembly [GO:0060271]; cilium disassembly [GO:0061523]; collateral sprouting [GO:0048668]; dendritic spine morphogenesis [GO:0060997]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte enucleation [GO:0043131]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; negative regulation of aggrephagy [GO:1905336]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of cellular response to oxidative stress [GO:1900409]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of tubulin deacetylation [GO:0090044]; positive regulation of type 2 mitophagy [GO:1905091]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein-containing complex disassembly [GO:0032984]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of macroautophagy [GO:0016241]; regulation of microtubule-based movement [GO:0060632]; regulation of mitochondrion organization [GO:0010821]; regulation of protein stability [GO:0031647]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to dexamethasone [GO:0071548]; response to growth factor [GO:0070848]; response to immobilization stress [GO:0035902]; response to misfolded protein [GO:0051788]; tubulin deacetylation [GO:0090042]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]" aggresome [GO:0016235]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; caveola [GO:0005901]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] "actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; tau protein binding [GO:0048156]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" CVSFQAR 1 0.6 0.90955 -0.3178 8.51286 0 3.47547 0 0 0 0 0 0 0 0 0 Q9UBP0 SPAST_HUMAN Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) SPAST ADPSP FSP2 KIAA1083 SPG4 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; cytoskeleton-dependent cytokinesis [GO:0061640]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle disassembly [GO:0051228]; nuclear membrane reassembly [GO:0031468]; positive regulation of cytokinesis [GO:0032467]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260] axon [GO:0030424]; axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; microtubule [GO:0005874]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922] alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]; protein-containing complex binding [GO:0044877] AGQKEQAVEWYK;DFGDTTV;TVMKTGSAGLSGHHR 3 5.5 0.96394 -1.0935 0 0 9.29186 2.96212 2.48918 0 9.8653 9.89709 0 0 7.81359 0 Q9UBP4 DKK3_HUMAN Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3) DKK3 REIC UNQ258/PRO295 Homo sapiens (Human) adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of anti-Mullerian hormone signaling pathway [GO:1902613]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615] co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019] RSHECIIDEDCGPSMYCQFASFQYTCQPCRGQR 1 9.4 0.86488 -0.089601 0 0 0 0 0 0 0 7.4065 11.2762 0 0 0 Q9UBP6 TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) METTL1 C12orf1 Homo sapiens (Human) cellular response to stress [GO:0033554]; RNA (guanine-N7)-methylation [GO:0036265]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527] internal mRNA (guanine-N7-)-methyltransferase activity [GO:0160090]; tRNA (guanine(46)-N7)-methyltransferase activity [GO:0008176]; tRNA binding [GO:0000049] VLRNGGK 1 2.5 0.96533 -1.2148 0 0 0 0 0 0 0 0 0 0 0 10.484 Q9UBP9 GULP1_HUMAN PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) GULP1 CED6 GULP Homo sapiens (Human) "apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911]" cytoplasm [GO:0005737] IPKVELQISIYGVKILEPK;IQDLETENMELK;MNRAFSRK 3 12.8 0.8933 -0.21787 0 0 0 0 0 0 0 11.5156 0 6.7021 0 7.31615 Q9UBQ6 EXTL2_HUMAN "Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) [Cleaved into: Processed exostosin-like 2]" EXTL2 EXTR2 Homo sapiens (Human) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; N-acetylglucosamine metabolic process [GO:0006044]; UDP-N-acetylgalactosamine metabolic process [GO:0019276] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654] "alpha-1,4-N-acetylgalactosaminyltransferase activity [GO:0035248]; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; glycosaminoglycan binding [GO:0005539]; manganese ion binding [GO:0030145]" EDKMLMLRR;VLRLSLVVILVLLLVAGALTALLPSVK 2 10.9 0.97707 -1.4963 0 0 0 0 0 0 0 0 0 12.5399 0 6.41676 Q9UBR1 BUP1_HUMAN Beta-ureidopropionase (EC 3.5.1.6) (BUP-1) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase) UPB1 BUP1 Homo sapiens (Human) beta-alanine biosynthetic process via 3-ureidopropionate [GO:0033396]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; pyrimidine nucleoside catabolic process [GO:0046135]; UMP catabolic process [GO:0046050] cytosol [GO:0005829]; extracellular exosome [GO:0070062] beta-ureidopropionase activity [GO:0003837]; protein homodimerization activity [GO:0042803] IAVNICYGR;LDLNLCQQVNDVWNFKMTGRYEMYAR 2 9.1 0.93983 -0.57963 0 0 0 0 0 9.0086 0 0 0 0 0 10.7675 Q9UBR2 CATZ_HUMAN Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) CTSZ Homo sapiens (Human) angiotensin maturation [GO:0002003]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] carboxypeptidase activity [GO:0004180]; cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] IVTSTYK 1 2.3 0.91152 -0.28638 0 0 0 0 0 0 0 0 0 11.376 11.0973 0 Q9UBR4 LHX3_HUMAN LIM/homeobox protein Lhx3 (LIM homeobox protein 3) LHX3 Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; inner ear development [GO:0048839]; lung development [GO:0030324]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of transcription by RNA polymerase II [GO:0006357]; somatotropin secreting cell differentiation [GO:0060126]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron cell fate specification [GO:0021520]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; ventral spinal cord interneuron specification [GO:0021521] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" LVCKADYETAKQR 1 3.3 0.83658 -0.034222 0 0 0 0 0 8.74588 0 0 0 0 0 0 Q9UBR5 CKLF_HUMAN Chemokine-like factor (C32) CKLF CKLF1 HSPC224 UNQ410/PRO772 Homo sapiens (Human) lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; secretion by cell [GO:0032940] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] chemokine activity [GO:0008009] MLRLVFALVTAVCCLADGALIYR 1 34.3 0.8359 -0.029624 0 0 0 0 0 0 0 0 10.1928 0 0 0 Q9UBS0 KS6B2_HUMAN Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) RPS6KB2 STK14B Homo sapiens (Human) negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of translational initiation [GO:0045948]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; translation [GO:0006412] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] APVSPLK;LTDFGLCK 2 3.1 0.90971 -0.31121 0 0 0 0 5.99908 0 6.81724 7.13268 0 7.91862 0 0 Q9UBS5 GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047] IIAEKEER 1 0.8 0.97927 -1.541 0 0 0 0 0 0 0 11.556 0 0 0 0 Q9UBS9 SUCO_HUMAN SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN-like protein 1) SUCO C1orf9 CH1 OPT SLP1 Homo sapiens (Human) ossification [GO:0001503]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of bone remodeling [GO:0046850] cytoplasm [GO:0005737]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867] ALALVSCLFLCSLVWLPSWR;ALEVNMSLSGR;KQMEEMQK;QLDIANYELFSSTPK;SALNASDNLK;SRSASAIALRTIGHILALLLR;VMEVEKEK;YLEELSQR 8 7.2 0.97743 -1.4938 0 9.3054 2.52727 9.75529 6.81198 10.7434 0 0 12.2188 9.42723 12.5863 0 Q9UBT2 SAE2_HUMAN SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) UBA2 SAE2 UBLE1B HRIHFB2115 Homo sapiens (Human) positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SUMO activating enzyme complex [GO:0031510] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; SUMO binding [GO:0032183]; transferase activity [GO:0016740]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] ALSRGLPR;ASNEDGDIKR;ELAEAVAGGR;KHVGRSK;LDEKENLSAK;VTVLTLQDKIVK 6 8.9 0.97411 -3.0315 0 14.8014 0 9.95117 0 0 0 0 10.2802 11.8203 11.787 0 Q9UBT3 DKK4_HUMAN Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form] DKK4 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hair follicle placode formation [GO:0061170]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615] co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019] SQLTSNR 1 3.1 0.94093 -0.58539 0 13.2922 0 0 0 0 0 0 0 0 0 11.378 Q9UBT6 POLK_HUMAN DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) POLK DINB1 Homo sapiens (Human) "cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]" nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] AAMPGFIAK;AGMEGLDKEK;ISSFPNEEDRKHQQR 3 3.9 0.90992 -0.28391 11.7757 0 0 0 8.88487 0 0 0 3.05249 9.67527 0 10.7421 Q9UBT7 CTNL1_HUMAN Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) CTNNAL1 Homo sapiens (Human) cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] LLLSSVTKVLLLADRVVIK;SVEQTLLPLVSQITTLINHK;VLATMERLEK 3 6.7 0.956 -0.83771 0 0 0 0 0 0 5.03461 0 0 0 4.68768 0 Q9UBU2 DKK2_HUMAN Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2) DKK2 UNQ682/PRO1316 Homo sapiens (Human) negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615] co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019] GHEGDPCLRSSDCIEGFCCAR;GLSCKVWK 2 11.2 0.97212 -1.3631 0 0 0 0 0 0 10.6727 0 0 0 0 0 Q9UBU6 FA8A1_HUMAN Protein FAM8A1 (Autosomal highly conserved protein) FAM8A1 AHCP Homo sapiens (Human) ERAD pathway [GO:0036503] Hrd1p ubiquitin ligase complex [GO:0000836] VGSAAPSRSPSETGRQAGR 1 4.6 0.85846 -0.081391 0 0 0 0 0 0 0 10.7919 0 0 0 0 Q9UBU7 DBF4A_HUMAN Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) DBF4 ASK DBF4A ZDBF1 Homo sapiens (Human) DNA replication [GO:0006260]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987] Dbf4-dependent protein kinase complex [GO:0031431]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] enzyme activator activity [GO:0008047]; nucleic acid binding [GO:0003676]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270] GHFQGGIQVKNEK;ILHIDDIRYYIEQKK;LVFDFVEYEKDTPKK;VEEFLSKDISYLISNK;VEEFLSKDISYLISNKK 5 8.9 0.96433 -1.1785 8.053 11.9203 9.17807 0 0 11.4597 0 0 10.8777 6.11956 0 0 Q9UBU8 MO4L1_HUMAN Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) MORF4L1 MRG15 FWP006 HSPC008 HSPC061 PP368 Homo sapiens (Human) chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; fibroblast proliferation [GO:0048144]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Sin3-type complex [GO:0070822] chromatin binding [GO:0003682] GAAPGKK;MRGAAPGK;TSGLQQKNVEVKTK 3 6.4 0.97256 -2.6 8.2131 9.61607 0 9.98741 10.3018 10.7841 8.93029 8.91298 0 0 0 0 Q9UBU9 NXF1_HUMAN Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) NXF1 TAP Homo sapiens (Human) mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear pore [GO:0005643]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] CSVPFTPIEFHYENTR;DPTLRFR;DQSTYISAIRERFPK;LDDMSSIVQK 4 7.8 0.9132 -0.38772 0 0 11.534 0 10.9159 0 0 0 10.4813 0 0 0 Q9UBV2 SE1L1_HUMAN Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) "ERAD pathway [GO:0036503]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839] LASEQQHSAQAMFNLGYMHEK 1 2.6 0.87608 -0.12139 0 0 0 0 0 0 0 0 0 0 0 11.3365 Q9UBV4 WNT16_HUMAN Protein Wnt-16 WNT16 Homo sapiens (Human) bone remodeling [GO:0046849]; canonical Wnt signaling pathway [GO:0060070]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of apoptotic signaling pathway [GO:2001234]; neuron differentiation [GO:0030182]; optic cup formation involved in camera-type eye development [GO:0003408]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; replicative senescence [GO:0090399]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] CRRCESMTDVHTCK 1 3.8 0.86878 -0.090719 0 0 0 0 9.35043 0 0 0 0 0 0 0 Q9UBV7 B4GT7_HUMAN "Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein 4-beta-galactosyltransferase) (EC 2.4.1.133) (Xylosylprotein beta-1,4-galactosyltransferase)" B4GALT7 XGALT1 UNQ748/PRO1478 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; glycosylation [GO:0070085]; negative regulation of fibroblast proliferation [GO:0048147]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; proteoglycan biosynthetic process [GO:0030166]; proteoglycan metabolic process [GO:0006029]; supramolecular fiber organization [GO:0097435] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; manganese ion binding [GO:0030145]; xylosylprotein 4-beta-galactosyltransferase activity [GO:0046525]" HHIYVLNQVDHFRFNR 1 4.9 0.91747 -0.42494 0 0 0 0 0 0 0 0 8.61548 0 0 0 Q9UBV8 PEF1_HUMAN Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) PEF1 ABP32 UNQ1845/PRO3573 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592] COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FIQVCTQLQVLTEAFR;NLFQQYDRDR 2 9.2 0.97788 -1.5019 7.03804 0 11.3091 0 0 0 0 0 0 0 0 0 Q9UBW5 BIN2_HUMAN Bridging integrator 2 (Breast cancer-associated protein 1) BIN2 BRAP1 Homo sapiens (Human) "cell chemotaxis [GO:0060326]; phagocytosis, engulfment [GO:0006911]; plasma membrane tubulation [GO:0097320]; podosome assembly [GO:0071800]" anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell projection [GO:0042995]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; secretory granule lumen [GO:0034774] phospholipid binding [GO:0005543] AIVWERIAK;ASLGTGTASPR;DERFEQSASNFYQQQAEGHK;LGKAVETK 4 9 0.9747 -3.4679 0 0 0 0 9.40657 0 0 0 0 7.11801 0 11.9446 Q9UBW7 ZMYM2_HUMAN Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) ZMYM2 FIM RAMP ZNF198 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605] ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270] CVTCNYCSQLCK;DFCSEDCCK;FCCQSCVSEYK;HWKKNPLTMENK;TQCRFFDMTQCIGPNGYMEPYCSTACMNSHK 5 5.4 0.98051 -1.6413 0 0 0 7.34625 0 6.76142 0 0 2.12535 6.904 0 0 Q9UBW8 CSN7A_HUMAN COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) COPS7A CSN7A DERP10 Homo sapiens (Human) COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EPAPGTNQRQPSKK 1 5.1 0.95504 -0.90034 0 0 0 0 0 0 0 12.198 0 0 0 0 Q9UBX0 HESX1_HUMAN Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf) HESX1 HANF Homo sapiens (Human) brain development [GO:0007420]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cadmium ion [GO:0071276]; ERK1 and ERK2 cascade [GO:0070371]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; gonad development [GO:0008406]; leukemia inhibitory factor signaling pathway [GO:0048861]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; otic vesicle formation [GO:0030916]; pituitary gland development [GO:0021983]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; thyroid gland development [GO:0030878] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" SHRESQFLMAKK 1 6.5 0.7707 0.054251 0 5.76569 0 0 0 0 0 10.1163 0 0 0 0 Q9UBX1 CATF_HUMAN Cathepsin F (CATSF) (EC 3.4.22.41) CTSF Homo sapiens (Human) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886] cysteine-type endopeptidase activity [GO:0004197] NLGGLETEDDYSYQGHMQSCNFSAEK;TLLCSFQVLDELGRHVLLRK 2 9.5 0.17713 0.33855 0 0 6.98993 0 0 0 0 8.09476 0 5.71501 0 0 Q9UBX5 FBLN5_HUMAN Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) FBLN5 DANCE UNQ184/PRO210 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; protein localization to cell surface [GO:0034394]; regulation of removal of superoxide radicals [GO:2000121]; secretion [GO:0046903] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803] CMCPAENPGCR 1 2.5 0.81005 0.0098785 0 0 0 0 5.562 0 0 0 0 0 0 0 Q9UBX7 KLK11_HUMAN Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] KLK11 PRSS20 TLSP UNQ649/PRO1279 Homo sapiens (Human) protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] ILQLILLALATGLVGGETRIIK;LLCGATLIAPR;SSGRGLTAAKEPGAR 3 17 0.981 -1.7477 0 7.9037 10.4005 0 8.62125 0 0 0 0 0 0 0 Q9UBX7 KLK11_HUMAN Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] KLK11 PRSS20 TLSP UNQ649/PRO1279 Homo sapiens (Human) protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] ILQLILLALATGLVGGETRIIK;LLCGATLIAPR;RILQLILLALATGLVGGETRIIK 3 13.6 0.59902 0.17852 0 0 0 8.02713 0 0 0 0 0 0 0 0 Q9UBY0 SL9A2_HUMAN Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] ASTSTSR;FLPEQFSK;KVTSSETDEIR 3 3.2 0.96449 -1.1173 0 0 0 0 9.46838 10.0305 0 0 0 0 0 0 Q9UBZ4 APEX2_HUMAN DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) APEX2 APE2 APEXL2 XTH2 Homo sapiens (Human) base-excision repair [GO:0006284]; DNA recombination [GO:0006310] fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; endonuclease activity [GO:0004519]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270] ALDSEGR;MRFYRLLQIR;STRPQPSQVGSSRGQK 3 6.4 0.98028 -1.8073 7.66541 0 0 11.7208 0 0 10.7023 10.3582 0 0 0 0 Q9UBZ9 REV1_HUMAN DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) REV1 REV1L Homo sapiens (Human) DNA replication [GO:0006260]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; response to UV [GO:0009411] nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; deoxycytidyl transferase activity [GO:0017125]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] ELKAAYDQR;RIQSPLNNKLLNSPAK;TCGDLQYMTMAK;WNGLHTPVSVQSR 4 4 0.94414 -0.63077 0 12.0055 4.67169 0 0 0 0 0 11.4432 0 0 0 Q9UC06 ZNF70_HUMAN Zinc finger protein 70 (Zinc finger protein N27C7-1) ZNF70 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LESQQGLFPGEDLGDPFLQER;SDLSMCQIIHSEEPSPCDCAETDR;THTREKPYVCNLCGKSFR 3 14.1 0.10226 0.36681 0 9.13114 0 0 0 0 0 0 0 9.4872 2.92048 0 Q9UC07 ZNF69_HUMAN Zinc finger protein 69 (hZNF3) ZNF69 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFIHSSSLR 1 1.6 0.93035 -0.48003 6.43739 0 10.0168 0 0 0 0 0 0 0 0 0 Q9UD71 PPR1B_HUMAN Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) PPP1R1B DARPP32 Homo sapiens (Human) behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; DNA-templated transcription [GO:0006351]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; negative regulation of female receptivity [GO:0007621]; response to amphetamine [GO:0001975]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; visual learning [GO:0008542] cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] ASGEGHHLKSK;EEDEEEEEDDEEEEEEEDSQAEVLK 2 17.6 0.95371 -0.89481 0 0 0 0 0 0 0 5.07275 0 0 11.7543 0 Q9UDR5 AASS_HUMAN "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "histone binding [GO:0042393]; saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity [GO:0047131]; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [GO:0004754]; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity [GO:0047130]; saccharopine dehydrogenase activity [GO:0004753]; transcription corepressor activity [GO:0003714]" KYNINPVSMDICK;QDLVISLLPYVLHPLVAKACITNK 2 4 0.75107 0.078845 0 0 0 0 9.12441 0 0 0 0 0 0 10.907 Q9UDT6 CLIP2_HUMAN CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) CLIP2 CYLN2 KIAA0291 WBSCR3 WBSCR4 WSCR4 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122] cell cortex [GO:0005938]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] ERSLNELR;ETVEGLQDK;EVHKAEWRIK;LEAELETVSR;LTGLDKEK;LTGLDKEKSLSDQR;VHELEKLDVEYR 7 6 0.97451 -3.8674 0 0 0 8.63383 0 0 0 10.0603 0 6.89336 12.5661 0 Q9UDV6 ZN212_HUMAN Zinc finger protein 212 (Zinc finger protein C2H2-150) ZNF212 ZNFC150 Homo sapiens (Human) "dendrite development [GO:0016358]; general adaptation syndrome, behavioral process [GO:0051867]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alcohol [GO:0097305]; walking behavior [GO:0090659]" nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" DTSRPYECSECEITFRYK;LHQCDVCLRSFSCKVSLVTHQR;YKQQLATHLR 3 9.7 0.96893 -1.3305 12.4547 0 0 0 6.75982 0 0 0 8.20804 0 0 0 Q9UDV7 ZN282_HUMAN Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] GLLDDGFQPHQGAALR 1 3.5 0.76468 0.060894 0 0 0 0 0 0 10.233 0 0 0 0 0 Q9UDW3 ZMAT5_HUMAN Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) (U11/U12-20K) ZMAT5 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] zinc ion binding [GO:0008270] RYFCDYCDR 1 5.3 0.75225 0.080577 7.68524 8.52117 0 0 0 0 0 0 0 0 0 0 Q9UDX3 S14L4_HUMAN SEC14-like protein 4 (Tocopherol-associated protein 3) SEC14L4 TAP3 Homo sapiens (Human) cytoplasm [GO:0005737] lipid binding [GO:0008289] IVILGDNWK;SYYLCEQVR 2 4.4 0.95274 -0.67888 0 0 0 0 0 0 0 0 0 0 0 11.6188 Q9UDX4 S14L3_HUMAN SEC14-like protein 3 (Tocopherol-associated protein 2) SEC14L3 TAP2 Homo sapiens (Human) cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] lipid binding [GO:0008289] MGERQRAGEMTDVLPSQR;VGDLSPK 2 6.2 0.91569 -0.39483 5.87115 0 0 0 0 0 9.2644 0 0 0 0 0 Q9UDX5 MTFP1_HUMAN Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18) MTFP1 MTP18 HSPC242 My022 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial fission [GO:0000266]; response to muscle activity [GO:0014850] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] AGEVPSPEAGR;DLYRDTWVR;GAERDLYR;SEPQPRGAERDLYR;WPLAVRK 5 22.3 0.97326 -2.9122 0 0 6.88154 0 0 0 0 10.8996 0 9.57268 4.19346 0 Q9UDY2 ZO2_HUMAN Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) TJP2 X104 ZO2 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; homotypic cell-cell adhesion [GO:0034109]; intestinal absorption [GO:0050892]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]; regulation of membrane permeability [GO:0090559] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; guanylate kinase activity [GO:0004385]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane transporter binding [GO:0044325] AASSDQLR;EELIWEQYTVTLQK;LSRMGATPTPFK;MEGMDDDPEDR;QRLNPTSNKSSR;VNTQDFR 6 5.5 0.97396 -3.0124 0 0 9.81266 0 0 8.43346 2.27932 0 0 0 0 5.82028 Q9UDY6 TRI10_HUMAN Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9) TRIM10 RFB30 RNF9 Homo sapiens (Human) erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] HTWVVSIDLAHGGSCTVGVVSEDVQRK 1 5.6 0.71259 0.15224 0 0 4.52287 0 0 0 0 0 0 5.44341 0 0 Q9UDY8 MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT Homo sapiens (Human) B cell activation [GO:0042113]; B-1 B cell differentiation [GO:0001923]; defense response [GO:0006952]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of T cell receptor signaling pathway [GO:0050856]; response to fungus [GO:0009620]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991] cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activator activity [GO:0061133]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; small molecule binding [GO:0036094]; ubiquitin-protein transferase activity [GO:0004842] LRLSCLDLEQCSLK 1 1.7 0.92147 -0.44573 0 0 0 0 0 0 0 0 0 0 9.82453 0 Q9UEE5 ST17A_HUMAN Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) STK17A DRAK1 Homo sapiens (Human) apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein phosphorylation [GO:0006468]; regulation of reactive oxygen species metabolic process [GO:2000377] nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ATAEECLK 1 1.9 0.93375 -0.50279 0 0 0 0 0 0 0 0 0 0 11.2031 0 Q9UEE9 CFDP1_HUMAN Craniofacial development protein 1 (Bucentaur) CFDP1 BCNT CENP-29 Homo sapiens (Human) cell adhesion [GO:0007155]; chromatin remodeling [GO:0006338]; fibroblast apoptotic process [GO:0044346]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360] kinetochore [GO:0000776]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] AEELEKPK;AFLDRVDHR;ITKVFDFAGEEVR;ITKVFDFAGEEVRVTK;LDWESFK;SFFKQNEK 6 16.1 0.97307 -2.6538 0 12.6041 0 0 0 8.70013 0 0 0 0 8.73769 10.5237 Q9UEF7 KLOT_HUMAN Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide] KL Homo sapiens (Human) calcium ion homeostasis [GO:0055074]; carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; energy reserve metabolic process [GO:0006112]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of systemic arterial blood pressure [GO:0003085]; norepinephrine biosynthetic process [GO:0042421]; positive regulation of bone mineralization [GO:0030501]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; response to activity [GO:0014823]; response to angiotensin [GO:1990776]; response to vitamin D [GO:0033280] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] beta-glucosidase activity [GO:0008422]; beta-glucuronidase activity [GO:0004566]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hormone activity [GO:0005179]; vitamin D binding [GO:0005499] GLFYVDFLSQDK;GYSIRRGLFYVDFLSQDK 2 1.8 0.8489 -0.0706 0 0 0 9.59281 0 0 10.6842 0 0 0 0 0 Q9UEG4 ZN629_HUMAN Zinc finger protein 629 (Zinc finger protein 65) ZNF629 KIAA0326 ZNF65 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDPFKCPVCGK 1 1.3 0.95337 -0.73337 0 0 0 0 0 0 0 0 0 8.44993 0 0 Q9UER7 DAXX_HUMAN Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) DAXX BING2 DAP6 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to heat [GO:0034605]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; chromatin remodeling [GO:0006338]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; JNK cascade [GO:0007254]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; nucleosome assembly [GO:0006334]; positive regulation of protein phosphorylation [GO:0001934]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625] LSQTPHSQPPRPGTCK 1 2.2 0.86731 -0.092993 0 0 0 0 0 11.3837 0 0 0 0 0 0 Q9UEU0 VTI1B_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) VTI1B VTI1 VTI1L VTI1L1 VTI2 Homo sapiens (Human) "Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane fusion [GO:0061025]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192]" cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; presynaptic endosome membrane [GO:0098954]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] ATQSIERSHR 1 4.3 0.88735 -0.18302 0 0 0 0 0 0 0 0 9.85613 0 0 0 Q9UEW3 MARCO_HUMAN Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2) MARCO SCARA2 Homo sapiens (Human) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; amyloid-beta clearance [GO:0097242]; apoptotic cell clearance [GO:0043277]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated endocytosis [GO:0006898]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; G protein-coupled receptor binding [GO:0001664]; pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888] RNGVNFSLAVVVIYLILLTAGAGLLVVQVLNLQARLR 1 7.1 0.37841 0.21876 0 0 2.87888 0 0 0 0 0 0 0 0 0 Q9UEW8 STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 PASK SPAK Homo sapiens (Human) cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELNDIRFEFTPGR;TEDGDWEWSDDEMDEK;TPDIAQRAK 3 7 0.97362 -1.4132 0 0 8.78705 0 0 0 0 5.04339 0 0 0 0 Q9UEY8 ADDG_HUMAN Gamma-adducin (Adducin-like protein 70) ADD3 ADDL Homo sapiens (Human) barbed-end actin filament capping [GO:0051016]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of vasoconstriction [GO:0045907]; response to xenobiotic stimulus [GO:0009410] brush border [GO:0005903]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein kinase C binding [GO:0005080]; structural constituent of cytoskeleton [GO:0005200] IREQNRYDLK;TGYAYRHPLIREKPR;VGEIEFEGLMR 3 5.1 0.98041 -1.7231 0 11.9399 9.01151 0 0 0 0 0 0 0 0 0 Q9UF02 CCG5_HUMAN Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) CACNG5 Homo sapiens (Human) "neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] channel regulator activity [GO:0016247]; monoatomic ion transmembrane transporter activity [GO:0015075]; voltage-gated calcium channel activity [GO:0005245] CPDYDQMSSSPC 1 4.4 0.89493 -0.24343 0 0 5.64962 0 0 0 0 0 0 0 0 0 Q9UF11 PKHB1_HUMAN Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1) PLEKHB1 EVT1 KPL1 PHR1 PHRET1 Homo sapiens (Human) phototransduction [GO:0007602]; regulation of cell differentiation [GO:0045595] cytoplasm [GO:0005737]; membrane [GO:0016020] SRDGLLTVNLREGGR;VLIHFNVR 2 9.5 0.92998 -0.4697 0 7.26857 0 8.41045 4.86745 0 0 0 0 8.09624 0 0 Q9UF12 HYPDH_HUMAN Hydroxyproline dehydrogenase (HYPDH) (EC 1.5.5.3) (Kidney and liver proline oxidase 1) (HsPOX1) (Probable proline dehydrogenase 2) (EC 1.5.5.2) (Probable proline oxidase 2) PRODH2 HSPOX1 HYPDH Homo sapiens (Human) proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; proline dehydrogenase activity [GO:0004657]" DAEAAHR;LHRVAQYAR 2 3.5 0.98065 -1.6748 0 0 0 6.30978 0 0 0 0 0 0 0 0 Q9UF33 EPHA6_HUMAN Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12) EPHA6 EHK2 HEK12 Homo sapiens (Human) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] dendrite [GO:0030425]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AFAGNTKCSK;TLKGGHMDR;VRTATGYSGYSQK 3 3.1 0.97225 -2.7304 6.60678 0 0 8.5256 0 0 8.44803 0 10.0341 0 10.8117 0 Q9UF56 FXL17_HUMAN F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) FBXL17 FBL17 FBX13 FBXO13 Homo sapiens (Human) entrainment of circadian clock by photoperiod [GO:0043153]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] CRELKDIHFGQCYK;EPPPETPDINQLPPSILLKIFSNLSLDER;ESPENPCDCHR;GPTPSPAELPTPPEMVCKRK;GVIHLTKLRNLSSLDLR;IFSNLSLDER;RPRCCSWCRR;VHVGNQDKLTDEGLK 8 16.5 0.95194 -0.7023 0 6.58486 0 0 8.00938 5.96077 5.29286 0 5.41937 0 6.56952 0 Q9UF83 YM012_HUMAN Uncharacterized protein DKFZp434B061 Homo sapiens (Human) extracellular space [GO:0005615] ASLMRTPPRASPTR;ASLTKMESTALLR;ASLTMTPSR;TPPRESPRMSHR;TPTRASLMRTPPR 5 9.2 0.97562 -2.3488 0 0 0 0 10.443 0 0 0 4.44201 0 0 0 Q9UFB7 ZBT47_HUMAN Zinc finger and BTB domain-containing protein 47 (Zinc finger protein 651) ZBTB47 KIAA1190 ZNF651 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" HSDEEEEDDEEEEEEEEEEEGGGSGR;KHMVAHTK 2 4.6 0.7109 0.14778 0 0 0 0 0 6.28681 0 0 0 0 0 0 Q9UFD9 RIM3A_HUMAN RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) RIMBP3 KIAA1666 RIMBP3A Homo sapiens (Human) fertilization [GO:0009566]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] benzodiazepine receptor binding [GO:0030156] AELEAERAGWRAER;AGCPYQADEKVKR;LADRARK;LNWLLAK;LQETNLR;QARELQRQLAEELVNR;VTFPVCPQK 7 4.5 0.98164 -1.7697 11.8863 10.5248 10.4436 0 9.69613 5.83355 0 0 9.45709 0 0 10.9359 Q9UFE4 CCD39_HUMAN Coiled-coil domain-containing protein 39 CCDC39 Homo sapiens (Human) axonemal dynein complex assembly [GO:0070286]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium-dependent cell motility [GO:0060285]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576] ALTLQLER;ASLQDELREYEER;EVDVQLNLIKGVLFKK;LENEMASILEK;LLEDQLSK;LSEKQAYSFQLSK;LTKEIRLLK;LTLECNQK;LTLECNQKR;SSLKHLNHQLQK;YAQQDDNK 11 11.4 0.97666 -5.5505 14.4988 0 1.94306 0 2.89801 0 11.9273 7.54928 0 0 13.6388 10.3708 Q9UFF9 CNOT8_HUMAN CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b) CNOT8 CALIF POP2 Homo sapiens (Human) "miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of translation [GO:0006417]" CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723] ELFFEDSIDDAK 1 4.1 0.80459 0.012896 0 0 0 8.20828 0 0 0 0 0 0 0 0 Q9UFH2 DYH17_HUMAN Dynein axonemal heavy chain 17 (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein axonemal light chain 2) DNAH17 DNAHL1 DNEL2 Homo sapiens (Human) cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AVSELQNPAIRER;AVTCDELFGIINPVTR;DLSNIFQGLLFSTAEVLK;EALLDLDGRIANLNKR;EKAAKWILAAVALLLQV;FLPWTDK;IQDLDRR;LFDSLCK;LQAEDSFVLK;LWLHETERVYGDK;NIYECPVYKTR;RYNYTTPK;SISAMEGIMEALSK;SLGMNDTR;TFLEQIKLYQNLLAK;TVLEMQPK;VVQLEELLQVR 17 4.5 0.97847 -7.3585 10.5401 9.04857 10.2783 10.8404 6.77096 9.87249 13.8606 12.0999 11.0515 10.6586 0 0 Q9UFV3 YO007_HUMAN Putative uncharacterized protein DKFZp434L187 Homo sapiens (Human) HMDLLTGYSK;LIQSRLKLLLHLGSQPPVGK 2 22.7 0.94441 -0.63194 0 0 0 0 10.2866 0 0 0 0 0 8.77834 0 Q9UFW8 CGBP1_HUMAN CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein) CGGBP1 CGGBP Homo sapiens (Human) epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802] VTEFGGELHEDGGK 1 8.4 0.87664 -0.13076 10.1366 0 0 0 0 0 0 0 0 0 0 0 Q9UG01 IF172_HUMAN Intraflagellar transport protein 172 homolog IFT172 KIAA1179 Homo sapiens (Human) bone development [GO:0060348]; brain development [GO:0007420]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epidermis development [GO:0008544]; heart looping [GO:0001947]; hindgut development [GO:0061525]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; left/right axis specification [GO:0070986]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of smoothened signaling pathway [GO:0045880]; protein processing [GO:0016485]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular vesicle [GO:1903561]; intraciliary transport particle B [GO:0030992]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] AFYEAGIAAK;AVGWDNMAFIFLNR;IGEDWGDKK;LYDDMIR;VAKELDPR 5 2.7 0.97704 -2.2212 0 11.5332 9.14608 0 0 0 7.83359 9.42356 0 9.88742 7.30177 10.0817 Q9UG22 GIMA2_HUMAN GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2) GIMAP2 IMAP2 Homo sapiens (Human) endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; identical protein binding [GO:0042802] QSLIKYMETQR 1 3.3 0.95166 -0.69997 0 0 0 0 0 8.72298 0 0 0 0 0 0 Q9UG56 PISD_HUMAN "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" PISD Homo sapiens (Human) lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] phosphatidylserine decarboxylase activity [GO:0004609] AWGRLNQVELPHWLRRPVYSLYIWTFGVNMK;IHTAPAR 2 9.3 0.69458 0.16208 0 0 0 0 0 0 0 0 0 10.5847 0 0 Q9UG56 PISD_HUMAN "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" PISD Homo sapiens (Human) lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] phosphatidylserine decarboxylase activity [GO:0004609] AWGRLNQVELPHWLRRPVYSLYIWTFGVNMK;MCQSEARQGPELR 2 11.7 0.93654 -0.54812 0 0 0 6.11836 10.6589 0 0 0 0 5.85397 0 0 Q9UG63 ABCF2_HUMAN ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2) ABCF2 HUSSY-18 Homo sapiens (Human) membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] KHSHVKIGR;LARQAQSK;LELEENQMKR;LMELYER;MPSDLAK;QTITKWPGDILAYKEHLK 6 9.5 0.97698 -5.668 0 0 0 0 0 0 0 10.3833 14.2683 9.80988 0 0 Q9UGC7 RF1ML_HUMAN "Peptide chain release factor 1-like, mitochondrial (Mitochondrial translational release factor 1-like) (mtRF1a)" MTRF1L MTRF1A Homo sapiens (Human) mitochondrial translational termination [GO:0070126] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]" VLWGAAR 1 1.8 0.93657 -0.5499 0 0 0 0 0 0 8.76045 0 0 0 0 0 Q9UGF7 O12D3_HUMAN Olfactory receptor 12D3 (Hs6M1-27) (Olfactory receptor OR6-27) OR12D3 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LFKDWQQHH 1 2.8 0.97946 -1.5458 0 0 0 0 0 0 0 0 0 0 9.56464 0 Q9UGH3 S23A2_HUMAN Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2 Homo sapiens (Human) blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229] SDNSRSSDEDSQATG 1 2.3 0.88337 -0.17499 0 0 0 0 0 0 0 0 0 0 5.8487 0 Q9UGI0 ZRAN1_HUMAN Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) ZRANB1 TRABID Homo sapiens (Human) cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]; regulation of cell morphogenesis [GO:0022604]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593] WSCHMCTYLNWPR 1 1.8 0.93723 -0.56716 8.19874 8.55252 0 8.04051 7.81186 5.33553 0 0 0 7.96918 0 0 Q9UGI8 TES_HUMAN Testin (TESS) TES Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285] cell junction [GO:0030054]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EGDPAIYAER;NVMILTNPVAAK 2 5.2 0.97453 -1.4259 0 10.209 0 0 0 0 0 0 0 9.85106 0 0 Q9UGI9 AAKG3_HUMAN 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) PRKAG3 AMPKG3 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; positive regulation of gluconeogenesis [GO:0045722]; regulation of carbon utilization [GO:0043609]; regulation of glycolytic process [GO:0006110]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] TIQDLGIGTFR 1 2.2 0.93049 -0.48877 12.9521 0 0 0 0 0 0 0 0 0 0 0 Q9UGJ0 AAKG2_HUMAN 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) PRKAG2 Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase activity [GO:0045860]; regulation of carbon utilization [GO:0043609]; regulation of D-glucose import [GO:0046324]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid oxidation [GO:0046320]; regulation of glycolytic process [GO:0006110]; sterol biosynthetic process [GO:0016126] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] ADP binding [GO:0043531]; AMP binding [GO:0016208]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; phosphorylase kinase regulator activity [GO:0008607]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] PLLDGDLEGSGKHSSR 1 3 0.91694 -0.42664 11.1672 0 0 0 0 0 0 0 0 0 0 0 Q9UGJ1 GCP4_HUMAN Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) TUBGCP4 76P GCP4 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200] EHKADATQAR;ILSSVRNHQINSDLAQLLLRLDYNK;QSSLLFKILSSVR 3 6.3 0.94663 -0.66138 0 0 7.87437 0 0 0 5.22612 0 0 0 0 0 Q9UGL1 KDM5B_HUMAN Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) KDM5B JARID1B PLU1 RBBP2H1 Homo sapiens (Human) branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; lens fiber cell differentiation [GO:0070306]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; regulation of estradiol secretion [GO:2000864]; response to fungicide [GO:0060992]; rhythmic process [GO:0048511]; single fertilization [GO:0007338]; uterus morphogenesis [GO:0061038] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; nucleic acid binding [GO:0003676]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] APAAPMIQCELCR;FPDNDLLRHLRLVTQDAEK;IKLSHPKDMNNFK;ILDLFQLNK;LVTQDAEK;MGFAPGK;SSPVRPSSEK 7 4.6 0.97244 -2.7287 0 0 10.7331 4.93093 0 0 0 9.92995 12.3625 9.80445 10.0418 0 Q9UGM3 DMBT1_HUMAN Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; protein transport [GO:0015031] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589] calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375] AYDPSSR;SKRDVGSYQEK 2 0.7 0.91751 -0.40917 0 9.12402 0 0 0 0 0 0 0 5.60493 0 0 Q9UGM5 FETUB_HUMAN Fetuin-B (16G2) (Fetuin-like protein IRL685) (Gugu) FETUB Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; negative regulation of endopeptidase activity [GO:0010951]; single fertilization [GO:0007338] extracellular exosome [GO:0070062]; extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191] DINKDRK;IFFESVYGQCK;LVVLPFPKEK 3 7.3 0.97384 -3.0171 0 0 0 0 0 0 0 9.24377 10.0185 0 0 9.65089 Q9UGM6 SYWM_HUMAN "Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)" WARS2 Homo sapiens (Human) mitochondrial tryptophanyl-tRNA aminoacylation [GO:0070183]; positive regulation of angiogenesis [GO:0045766]; tRNA aminoacylation for protein translation [GO:0006418]; vasculogenesis [GO:0001570] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830] DPSAKMSKSDPDK;SLRDPSAKMSK 2 4.4 0.97356 -1.4156 0 0 0 0 0 0 0 0 11.9824 0 9.51936 0 Q9UGN4 CLM8_HUMAN CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) CD300A CMRF35H IGSF12 HSPC083 Homo sapiens (Human) "cell adhesion [GO:0007155]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of eosinophil activation [GO:1902567]; negative regulation of eosinophil migration [GO:2000417]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of NK T cell activation [GO:0051134]; negative regulation of phagocytosis, engulfment [GO:0060101]; regulation of innate immune response [GO:0045088]; regulation of T cell receptor signaling pathway [GO:0050856]; signal transduction [GO:0007165]" extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; signaling receptor activity [GO:0038023] IAAQRPR;TVAGPVGGSLSVQCPYEK 2 8.4 0.91688 -0.42303 0 0 0 12.2465 12.2827 0 0 0 0 7.14507 0 0 Q9UGN5 PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) PARP2 ADPRT2 ADPRTL2 Homo sapiens (Human) base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004] ELSEKIQLLEALGDIEIAIKLVK;TEDKQDESVK;VGKMGQHSLVACSGNLNK 3 8.9 0.9801 -1.7171 12.1594 6.80025 0 0 0 0 0 0 0 7.87227 0 0 Q9UGP4 LIMD1_HUMAN LIM domain-containing protein 1 LIMD1 Homo sapiens (Human) cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; P-body assembly [GO:0033962]; phosphorylation [GO:0016310]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AFYFVNGK;IYCVRDYHK;LEALTQRLEREMDAHPK 3 5 0.98077 -2.0216 0 10.2767 10.5278 0 0 0 0 12.0152 0 0 0 0 Q9UGP5 DPOLL_HUMAN DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) POLL Homo sapiens (Human) "base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; somatic hypermutation of immunoglobulin genes [GO:0016446]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] ALRLLRLPQLPPGAQLVK;GILKAFPKR 2 4.7 0.96344 -1.0901 0 0 0 0 0 0 4.5909 0 0 0 0 0 Q9UGP8 SEC63_HUMAN Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) SEC63 DNAJC23 SEC63L Homo sapiens (Human) "liver development [GO:0001889]; nitrogen cycle metabolic process [GO:0071941]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]" endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; Sec62/Sec63 complex [GO:0031207] protein transmembrane transporter activity [GO:0008320]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023] EDEEEVSDKGSDSEEEETNR;EIGSINLK;KIVLLAGWALFLFLAYK;KPLKKKPTPVLLPQSK;LLKPQPNIIPTVKK;LRLLKPQPNIIPTVKK;TIQDLVSLKESDR 7 11.7 0.98096 -1.6976 0 0 12.9011 0 0 6.01643 0 11.2743 10.5918 8.78914 3.93244 0 Q9UGQ3 GTR6_HUMAN "Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6)" SLC2A6 GLUT6 Homo sapiens (Human) D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; regulation of glycolytic process [GO:0006110]; transmembrane transport [GO:0055085] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; transmembrane transporter activity [GO:0022857] SLEQIESFFRTGR;SLEQIESFFRTGRR 2 2.8 0.98026 -1.5957 0 0 0 0 0 0 9.74423 0 0 0 0 12.207 Q9UGR2 Z3H7B_HUMAN Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN) ZC3H7B KIAA1031 Homo sapiens (Human) miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] CRCAHGQEELNEWLDRR;DLLFDPLGGVK;FVCGQCWR;LRSSEDQTWK;NGQVVEPDKDLKYCSAK;QIQMPTDYADIMMGYHCWLCGK;RDILLGRLR 7 9.4 0.97619 -5.2661 0 0 0 0 0 0 10.9034 10.8155 0 5.17748 9.25354 0 Q9UGU0 TCF20_HUMAN Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) TCF20 KIAA0292 SPBP Homo sapiens (Human) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] LEEFSPR;SLSRGLPCK;SPGSLRYSYK;VPGRVGGR;YATQPLDK 5 2.1 0.97433 -3.788 0 9.9577 0 0 8.88246 0 11.2325 0 0 0 0 0 Q9UGU5 HMGX4_HUMAN HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) HMGXB4 HMG2L1 HMGBCG Homo sapiens (Human) endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] NURF complex [GO:0016589] DNA binding [GO:0003677]; identical protein binding [GO:0042802] AYDDSVK;AYDDSVKK;DSELYFLGTDTHK;QLPEKDKLIWK 4 5.3 0.96888 -1.3317 0 0 10.6268 8.32809 0 8.90896 0 0 0 0 0 0 Q9UGV2 NDRG3_HUMAN Protein NDRG3 (N-myc downstream-regulated gene 3 protein) NDRG3 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] YFLQGMGYIPSASMTR 1 4.3 0.90435 -0.26798 0 0 0 0 0 0 0 0 9.73122 0 0 0 Q9UH17 ABC3B_HUMAN DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3) APOBEC3B Homo sapiens (Human) clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; transposable element silencing [GO:0010526] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] cytidine deaminase activity [GO:0004126]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] IYDYDPLYK;LSQAGAR 2 4.2 0.95488 -0.95047 0 0 0 0 0 0 0 0 8.12262 9.44089 0 0 Q9UH62 ARMX3_HUMAN Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) ARMCX3 ALEX3 BM-017 UNQ2517/PRO6007 Homo sapiens (Human) axonal transport of mitochondrion [GO:0019896]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104] axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] EKMAEGGSGDVDDAGDCSGAR;LLLNLAENPAMTRELLR;VGKFMAKLAEHMFPK;VKVGKFMAK;YNDWSDDDDDSNESK 5 18.5 0.91323 -0.38167 0 0 6.72629 0 6.13777 5.51551 10.7247 0 9.90845 0 0 0 Q9UH64 NSGX_HUMAN Putative uncharacterized protein CDKN2A-AS1 (CDKN2A antisense RNA 1) (CDKN2A antisense gene protein 1) (Protein CDKN2A-DT) (Susceptibility protein NSG-x) CDKN2A-AS1 C9orf53 CDKN2A-DT Homo sapiens (Human) QRGQEHLPTSVKSEPR 1 20.3 0.95481 -0.97513 11.4764 0 0 0 0 0 0 0 0 0 0 0 Q9UH65 SWP70_HUMAN Switch-associated protein 70 (SWAP-70) SWAP70 KIAA0640 HSPC321 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085] ELQAANESK;IEFNRMCWTLCVKK;LIRQQMEEQVAQK 3 6.2 0.98083 -1.7408 0 0 0 0 0 0 9.97513 0 0 0 0 0 Q9UH73 COE1_HUMAN Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) EBF1 COE1 EBF Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RLDPSEGTPSYLEHATPCIK 1 3.4 0.30455 0.24938 0 0 0 0 0 0 0 0 0 0 6.67228 0 Q9UH73 COE1_HUMAN Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) EBF1 COE1 EBF Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLLTHEIMCRFFLK 1 2.5 0.95271 -0.6818 0 0 0 0 0 0 0 0 0 0 10.0816 0 Q9UH77 KLHL3_HUMAN Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) distal tubule morphogenesis [GO:0072156]; gene expression [GO:0010467]; macroautophagy [GO:0016236]; monoatomic ion homeostasis [GO:0050801]; potassium ion homeostasis [GO:0055075]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; cullin family protein binding [GO:0097602]; structural molecule activity [GO:0005198]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DFLIEAMK;SVECYDFEEDR;TPVSLPK;TVDVYDGVK;YHLLPLDQRLLIK 5 8.2 0.97857 -2.0605 13.4486 11.3232 0 0 5.31212 0 7.66839 7.56301 0 0 0 5.6579 Q9UH90 FBX40_HUMAN F-box only protein 40 (Muscle disease-related protein) FBXO40 FBX40 KIAA1195 Homo sapiens (Human) muscle cell differentiation [GO:0042692] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DFVYGKLEAQEVKTVYTFK;LEAQEVK;NICATLLQER;TKEGMDLVKFGQWENIFSK;TTLQCALER;VPVSYCGK 6 9.2 0.96878 -1.331 0 0 0 8.96982 9.48285 0 10.2286 0 9.31148 9.80345 0 0 Q9UH99 SUN2_HUMAN SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) SUN2 FRIGG KIAA0668 RAB5IP UNC84B Homo sapiens (Human) centrosome localization [GO:0051642]; meiotic cell cycle [GO:0051321]; mitotic spindle organization [GO:0007052]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335] "chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; endosome membrane [GO:0010008]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]" cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; protein-membrane adaptor activity [GO:0043495] ALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGK 1 4.6 0.83343 -0.027247 0 0 0 0 0 0 9.29618 0 0 0 0 0 Q9UHA3 RLP24_HUMAN Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like) RSL24D1 C15orf15 RPL24L My024 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273]; translation [GO:0006412] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] MVQQLQEDVDMEDAP 1 9.2 0.61726 0.17407 0 0 5.05511 0 0 0 0 0 0 0 0 0 Q9UHA7 IL36A_HUMAN Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6) IL36A FIL1E IL1E IL1F6 Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] VGDQPTLQLKEK 1 7.6 0.92545 -0.45157 0 0 0 0 0 0 0 0 0 2.34273 0 0 Q9UHB4 NDOR1_HUMAN NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1) NDOR1 NR1 Homo sapiens (Human) electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] "electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]" DQDFYWEAEWQELEKR 1 2.7 0.57101 0.18158 0 0 0 4.19235 0 0 0 0 0 0 0 0 Q9UHB6 LIMA1_HUMAN LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) LIMA1 EPLIN SREBP3 PP624 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; intestinal cholesterol absorption [GO:0030299]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cilium assembly [GO:1902018]; ruffle organization [GO:0031529] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; brush border membrane [GO:0031526]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872] ASKKNGNVGK;ESKGETGK;ISANENSLAVR;LSETSIKDR;NRYYDEDEDEE;SEISENTDASGKIEK;SPKTVSPPIR;TVYPMER;VGVLAASMEAK;YNVPLNR 10 13 0.97358 -2.4698 10.7997 11.6019 11.3349 10.2921 9.66589 10.5285 10.6696 11.4796 11.7601 11.7363 10.6046 12.2559 Q9UHB7 AFF4_HUMAN AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) AFF4 AF5Q31 MCEF HSPC092 Homo sapiens (Human) regulation of gene expression [GO:0010468]; response to endoplasmic reticulum stress [GO:0034976]; spermatid development [GO:0007286] euchromatin [GO:0000791]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] HTREAQK;IPGKPYKETEPPK;LSSSEDSDGEQDCDK;QKSPAQSDSTTQRR 4 4.2 0.95213 -0.77048 0 0 8.38427 0 9.37489 0 0 0 10.8919 9.0162 0 0 Q9UHB9 SRP68_HUMAN Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) SRP68 Homo sapiens (Human) response to xenobiotic stimulus [GO:0009410]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; ribosome [GO:0005840]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] LSTAIKRNENMAK;TLNFKMGNRHK;VTEELLTDNR 3 5.4 0.80937 0.0094376 11.489 0 0 10.0459 0 7.5694 0 0 0 0 7.27845 0 Q9UHC1 MLH3_HUMAN DNA mismatch repair protein Mlh3 (MutL protein homolog 3) MLH3 Homo sapiens (Human) female meiosis I [GO:0007144]; male meiotic nuclear division [GO:0007140]; mismatch repair [GO:0006298]; protein localization [GO:0008104]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130] chiasma [GO:0005712]; male germ cell nucleus [GO:0001673]; mismatch repair complex [GO:0032300]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; mismatched DNA binding [GO:0030983]; satellite DNA binding [GO:0003696] ACSETEESNTCCSDWQR;AERTVMRQDNR;ESPMTLKELSLFNRKPLDLEK;GEALANIADMASAVEISSKK;LLWCYHK;MFLKQEK;MIKCLSVEVQAK;RLVLRTK;TVMRQDNR;VPLCFVER 10 7.6 0.9766 -4.9547 0 8.06269 0 0 4.27389 9.7829 4.39938 7.77023 0 11.6518 7.86121 0 Q9UHC3 ASIC3_HUMAN Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) ASIC3 ACCN3 SLNAC1 TNAC1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; sensory perception [GO:0007600]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enterobactin transmembrane transporter activity [GO:0042931]; ligand-gated sodium channel activity [GO:0015280]; monoatomic cation channel activity [GO:0005261]; pH-gated monoatomic ion channel activity [GO:0160128]; sodium channel activity [GO:0005272] TLSASHR;TLSASHRTCYLVTQL;VLGYFWNRQHSQR 3 5.3 0.96383 -1.2027 10.6876 0 0 0 0 0 10.0056 0 0 9.61388 0 0 Q9UHC6 CNTP2_HUMAN Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) CNTNAP2 CASPR2 KIAA0868 Homo sapiens (Human) adult behavior [GO:0030534]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; clustering of voltage-gated potassium channels [GO:0045163]; learning [GO:0007612]; limbic system development [GO:0021761]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; positive regulation of gap junction assembly [GO:1903598]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; social behavior [GO:0035176]; striatum development [GO:0021756]; superior temporal gyrus development [GO:0071109]; thalamus development [GO:0021794]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625] axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] enzyme binding [GO:0019899]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325] LSVGPLR;LSVGPLRCQGDR;VTSGFISGCSGHCTSYGTNCENGGK;YHGYSCDCSNTAYDGTFCNK;YYCNCDADYK 5 5 0.95771 -0.99984 0 0 0 0 7.33619 6.00876 0 0 0 0 7.0237 10.0454 Q9UHC7 MKRN1_HUMAN E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) MKRN1 RNF61 Homo sapiens (Human) protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] QVTCRYFMHGVCK 1 2.7 0.92159 -0.44684 0 0 0 0 6.41464 0 0 0 0 0 0 0 Q9UHC9 NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1) NPC1L1 Homo sapiens (Human) cellular response to sterol depletion [GO:0071501]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipoprotein metabolic process [GO:0042157]; sterol transport [GO:0015918]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; myosin V binding [GO:0031489]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; vitamin E binding [GO:0008431] EVHIGRALGR;GAGAISNFLPNNGRQF 2 1.9 0.88178 -0.1604 0 0 0 0 0 0 9.22506 9.03527 11.3434 0 0 0 Q9UHD1 CHRD1_HUMAN Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) CHORDC1 CHP1 Homo sapiens (Human) centrosome duplication [GO:0051298]; chaperone-mediated protein folding [GO:0061077]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824] ADP binding [GO:0043531]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; zinc ion binding [GO:0008270] TYQGLESLEEVCVYHSGVPIFHEGMK 1 7.8 0.71214 0.14778 0 0 0 0 0 0 0 0 0 10.2125 0 0 Q9UHD8 SEPT9_HUMAN Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) SEPTIN9 KIAA0991 MSF SEPT9 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; protein localization [GO:0008104] actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; non-motile cilium [GO:0097730]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] AAEPVSRR;AEVLGHK;AMKQGFEFNIMVVGQSGLGK;EFDEDSEDR;EMIPFAVVGSDHEYQVNGK;RLSKVVNIVPVIAK;SITHDIEEK;TPEPAPR;VELSGPK;VVNIVPVIAK 10 17.1 0.978 -2.1552 13.6066 13.8813 13.9762 11.7975 0 4.4978 13.1025 5.33739 9.38892 9.96378 8.89142 8.80426 Q9UHD8 SEPT9_HUMAN Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) SEPTIN9 KIAA0991 MSF SEPT9 Homo sapiens (Human) cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; protein localization [GO:0008104] actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; non-motile cilium [GO:0097730]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] AMKQGFEFNIMVVGQSGLGK;EFDEDSEDR;EMIPFAVVGSDHEYQVNGK;EPPASKVPEVPTAPATDAAPKR;RLSKVVNIVPVIAK;SITHDIEEK;VVNIVPVIAK 7 22 0.55138 0.18342 0 0 0 0 0 8.83624 0 9.07009 0 0 0 0 Q9UHD9 UBQL2_HUMAN Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) UBQLN2 N4BP4 PLIC2 HRIHFB2157 Homo sapiens (Human) autophagosome assembly [GO:0000045]; ERAD pathway [GO:0036503]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of ERAD pathway [GO:1904294]; regulation of autophagosome assembly [GO:2000785]; regulation of macroautophagy [GO:0016241]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; polyubiquitin modification-dependent protein binding [GO:0031593] IIKVTVKTPK 1 1.6 0.87191 -0.10361 0 0 0 0 0 0 0 0 9.54896 0 0 0 Q9UHE5 NAT8_HUMAN N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80) NAT8 CML1 GLA TSC501 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; glutathione metabolic process [GO:0006749]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020] "cysteine-S-conjugate N-acetyltransferase activity [GO:0047198]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]" LQLFHLFVDSEHRR 1 6.2 0.64099 0.17253 0 0 0 0 0 0 0 0 0 3.44599 0 0 Q9UHE8 STEA1_HUMAN STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) STEAP1 PRSS24 STEAP Homo sapiens (Human) cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] heme binding [GO:0020037]; metal ion binding [GO:0046872] LLNWAYQQVQQNK;MEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSK 2 15.9 0.8663 -0.088631 10.61 0 0 0 0 0 0 10.0423 0 0 0 0 Q9UHF0 TKNK_HUMAN Tachykinin-3 (ZNEUROK1) [Cleaved into: Neurokinin-B (NKB) (Neuromedin-K)] TAC3 NKNB UNQ585/PRO1155 Homo sapiens (Human) female pregnancy [GO:0007565]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; tachykinin receptor signaling pathway [GO:0007217] extracellular region [GO:0005576]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] EPQEEVVPGGGR 1 9.9 0.91524 -0.37712 0 0 0 0 0 0 0 0 0 11.2346 0 0 Q9UHF1 EGFL7_HUMAN Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102] ACSTYRTIYR;CVNTAGSYWCQCWEGHSLSADGTLCVPK 2 13.9 0.37913 0.22149 0 0 0 9.30677 0 0 0 0 0 9.01514 0 0 Q9UHF3 NAT8B_HUMAN Putative N-acetyltransferase 8B (EC 2.3.1.-) (Acetyltransferase 1) (ATase1) (Camello-like protein 2) NAT8B CML2 Homo sapiens (Human) amyloid fibril formation [GO:1990000]; amyloid-beta metabolic process [GO:0050435]; gastrulation with mouth forming second [GO:0001702]; negative regulation of apoptotic process [GO:0043066]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020] "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]" EKRLQLFHLSVDNEHR 1 7 0.96548 -1.1445 0 0 0 0 0 10.2976 0 0 0 0 0 0 Q9UHF4 I20RA_HUMAN Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7) IL20RA UNQ681/PRO1315 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124] plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015] SISVVLTAPEK 1 2.5 0.80656 0.01229 0 0 0 6.55526 6.14325 7.06512 0 0 0 0 0 0 Q9UHF7 TRPS1_HUMAN Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) TRPS1 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" IDFRVYNLLTPDSK;ILALHNMVQFSHSKDFQK;LLEHYGK;QNNGEQIIRRR;SSSGAKK;TKAPPNVK;VYNLLTPDSK 7 5.1 0.97858 -1.968 0 10.5352 0 0 0 0 0 8.49414 9.26266 0 8.36558 11.2599 Q9UHG0 DCDC2_HUMAN Doublecortin domain-containing protein 2 (Protein RU2S) DCDC2 KIAA1154 RU2 Homo sapiens (Human) cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605] axoneme [GO:0005930]; centriolar satellite [GO:0034451]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinocilium [GO:0060091]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686] kinesin binding [GO:0019894] ASSLPPIVGSR 1 2.3 0.89822 -0.2336 0 0 0 0 0 0 0 0 0 0 6.62254 0 Q9UHG0 DCDC2_HUMAN Doublecortin domain-containing protein 2 (Protein RU2S) DCDC2 KIAA1154 RU2 Homo sapiens (Human) cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605] axoneme [GO:0005930]; centriolar satellite [GO:0034451]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinocilium [GO:0060091]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686] kinesin binding [GO:0019894] MKMWNNWGWCGGR 1 5.7 0.92178 -0.44693 0 0 0 0 0 0 0 0 0 0 0 3.6495 Q9UHG3 PCYOX_HUMAN Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183 Homo sapiens (Human) prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] extracellular exosome [GO:0070062]; lysosome [GO:0005764]; very-low-density lipoprotein particle [GO:0034361] FAD binding [GO:0071949]; farnesylcysteine lyase activity [GO:0102149]; prenylcysteine oxidase activity [GO:0001735] LVWRYGFQSLR;TLLETLQK 2 3.8 0.96194 -1.0699 0 0 0 0 0 0 0 0 0 9.59781 6.38092 0 Q9UHH9 IP6K2_HUMAN Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) IP6K2 IHPK2 TCCCIA00113 Homo sapiens (Human) cellular response to flavonoid [GO:1905396]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cell growth [GO:0030308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of apoptotic process [GO:0043065]; protein stabilization [GO:0050821] cell junction [GO:0030054]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; diphosphoinositol tetrakisphosphate kinase activity [GO:0052839]; flavonoid binding [GO:0097243]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" LEEEFEWLK 1 2.1 0.88639 -0.19392 0 0 0 8.86372 0 0 10.8721 11.0142 0 0 0 0 Q9UHI5 LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) SLC7A8 LAT2 Homo sapiens (Human) amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; valine transport [GO:0015829] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; organic cation transmembrane transporter activity [GO:0015101]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534] DIFGGLAGFLR;DVAGQPQP 2 3.6 0.93679 -0.52437 0 0 0 0 0 0 9.11239 9.15575 7.88972 0 0 0 Q9UHI6 DDX20_HUMAN Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) DDX20 DP103 GEMIN3 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; positive regulation of apoptotic process [GO:0043065]; regulation of steroid biosynthetic process [GO:0050810]; RNA processing [GO:0006396]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; RNA helicase activity [GO:0003724] EGASQRAKQSR 1 1.3 0.9599 -1.0502 0 3.26822 0 0 0 0 0 0 0 0 0 12.4671 Q9UHI8 ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1) ADAMTS1 KIAA1346 METH1 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508] basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] AGCDRIIDSK;DINGQPASECAK;YAGVSPK 3 3 0.95728 -1.0263 0 0 0 0 0 8.31642 0 0 0 0 2.78346 0 Q9UHJ3 SMBT1_HUMAN Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) SFMBT1 RU1 Homo sapiens (Human) cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; spermatogenesis [GO:0007283] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] MVLDKCSENCSVLTKTK;RKNVFVHK;VLRELQLDKDSVWHGCGEVLK;YDGYGEDRRADFWCDIR 4 7.3 0.98111 -1.6983 7.33682 9.23876 0 0 0 0 0 0 0 0 0 7.08789 Q9UHJ6 SHPK_HUMAN Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) SHPK CARKL Homo sapiens (Human) "carbohydrate metabolic process [GO:0005975]; cellular response to interleukin-13 [GO:0035963]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; phosphorylation [GO:0016310]; regulation of inflammatory response [GO:0050727]; regulation of macrophage activation [GO:0043030]" cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; sedoheptulokinase activity [GO:0050277] AARPITLGIDLGTTSVKAALLR 1 4.6 0.82901 -0.025381 0 12.5101 0 0 0 0 0 0 0 0 0 0 Q9UHJ9 PGAP2_HUMAN Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) PGAP2 FRAG1 Homo sapiens (Human) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020] MARLGSTGGVSGR 1 4.2 0.98027 -1.564 0 0 0 0 0 9.86006 0 0 0 0 0 0 Q9UHK0 NUFP1_HUMAN FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) NUFIP1 Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396] fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; pre-snoRNP complex [GO:0070761]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; transcription elongation factor complex [GO:0008023] ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] SPGKNHK 1 1.4 0.40486 0.20682 0 11.5744 0 0 0 0 0 0 0 0 0 0 Q9UHK6 AMACR_HUMAN Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) AMACR Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] alpha-methylacyl-CoA racemase activity [GO:0008111]; signaling receptor binding [GO:0005102] LSLWEAPR 1 2.1 0.91414 -0.39033 0 0 0 0 9.66796 0 0 0 0 0 0 0 Q9UHL3 F153A_HUMAN Protein FAM153A (Renal carcinoma antigen NY-REN-7) FAM153A KIAA0752 Homo sapiens (Human) ELHLYSTWK;VDKDTER 2 5.2 0.98113 -1.7893 0 0 0 9.798 0 0 0 0 0 0 0 0 Q9UHL4 DPP2_HUMAN Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) DPP7 DPP2 QPP Homo sapiens (Human) lysosomal protein catabolic process [GO:1905146]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] SLPFGAQSTQR;VGCDRLLSEAQR 2 4.7 0.90336 -0.26582 3.89433 0 0 0 0 0 0 0 0 8.22723 0 0 Q9UHL9 GT2D1_HUMAN General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transition between slow and fast fiber [GO:0014886] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIGISEPVK;GLSEDARPEERPVEDSHGDVIRPLR;ILFSIVHDK;KQVELLFNTRYAK;MVIINQLQPFAEICNDAK 5 7.7 0.97966 -1.8556 0 11.7403 11.3811 0 6.22292 0 9.00042 10.7306 0 9.20867 0 0 Q9UHM6 OPN4_HUMAN Melanopsin (Opsin-4) OPN4 MOP Homo sapiens (Human) cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; optokinetic behavior [GO:0007634]; phototransduction [GO:0007602]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; rhythmic process [GO:0048511]; thermotaxis [GO:0043052]; visual perception [GO:0007601] axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020] GVTVMMQSRSLR;STHRSTLTSHTSNLSWISIR 2 6.5 0.96603 -1.2607 0 0 0 0 0 0 0 8.67486 0 0 0 0 Q9UHN6 CEIP2_HUMAN Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2) CEMIP2 KIAA1412 TMEM2 Homo sapiens (Human) angiogenesis [GO:0001525]; hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyalurononglucosaminidase activity [GO:0004415] EYLCLDNSAR;GINQKAAFPQYQPVVMLEK 2 2.1 0.89182 -0.21576 0 0 0 0 0 0 6.69279 0 8.65746 10.2653 0 9.43592 Q9UHP3 UBP25_HUMAN Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) USP25 USP21 Homo sapiens (Human) negative regulation of ERAD pathway [GO:1904293]; negative regulation of interleukin-17-mediated signaling pathway [GO:1903882]; negative regulation of response to oxidative stress [GO:1902883]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; peptidase activity [GO:0008233]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783] DSNGNLELAVAFLTAKNAK;LTDFLPK;NLPFMRELR;TIELMYSDKSMIQVPYR 4 4.9 0.97598 -1.453 0 0 0 9.0351 0 0 10.7162 12.0486 0 0 0 0 Q9UHP6 RSP14_HUMAN Radial spoke head 14 homolog (Rhabdoid tumor deletion region protein 1) RSPH14 RTDR1 Homo sapiens (Human) motile cilium [GO:0031514]; radial spoke [GO:0001534] ALLKDSNSMVRIK;ALTMLAEAPEGR 2 7.2 0.96004 -1.053 0 0 13.7541 0 0 0 8.9107 0 0 0 0 0 Q9UHP7 CLC2D_HUMAN C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin) CLEC2D CLAX LLT1 OCIL Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] MHDSNNVEK;WICSKSDIHV 2 9.9 0.89887 -0.25756 0 0 0 0 0 0 8.56083 0 0 0 0 3.26323 Q9UHP9 SMPX_HUMAN Small muscular protein (Stretch-responsive skeletal muscle protein) SMPX SRMX Homo sapiens (Human) striated muscle contraction [GO:0006941] costamere [GO:0043034]; M band [GO:0031430]; muscle tendon junction [GO:0005927]; nucleus [GO:0005634] QPVSNVR 1 8 0.91082 -0.32063 7.4851 0 0 0 0 0 0 0 0 0 0 0 Q9UHQ1 NARF_HUMAN Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2) NARF Homo sapiens (Human) lamin filament [GO:0005638]; nuclear lamina [GO:0005652]; nuclear lumen [GO:0031981]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] lamin binding [GO:0005521] HAAKELFNEDVEEVTYR 1 3.7 0.91806 -0.43537 10.0076 0 0 0 0 0 0 0 0 0 0 0 Q9UHQ4 BAP29_HUMAN B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29) BCAP29 BAP29 Homo sapiens (Human) apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; osteoblast differentiation [GO:0001649]; protein localization to endoplasmic reticulum exit site [GO:0070973] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] AFLTIIILLIVLFLDAVR;EYDQLLKEHSELQDRLER;FMEENEKLK;LVEDQEKLK 4 22.4 0.98157 -1.5789 0 0 0 0 10.1838 0 0 10.3458 11.4455 0 0 0 Q9UHQ7 TCAL9_HUMAN Transcription elongation factor A protein-like 9 (TCEA-like protein 9) (Transcription elongation factor S-II protein-like 9) (WW domain-binding protein 5) (WBP-5) TCEAL9 WBP5 Homo sapiens (Human) nucleus [GO:0005634] EVDEIDEIRRVR;LIQSLQEFK;LIQSLQEFKEDIHNR;LIVMRWK 4 32.7 0.97847 -1.9751 0 0 0 0 0 0 10.3304 0 11.278 0 0 0 Q9UHQ9 NB5R1_HUMAN NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) CYB5R1 NQO3A2 UNQ3049/PRO9865 Homo sapiens (Human) bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]" LWFTLDHPPKDWAYSK 1 5.2 0.94512 -0.64403 0 0 0 0 0 0 0 0 0 8.8141 0 0 Q9UHR4 BI2L1_HUMAN BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) BAIAP2L1 IRTKS Homo sapiens (Human) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin cytoskeleton organization [GO:0032956] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; proline-rich region binding [GO:0070064] LNESLDENFKK 1 2.2 0.73125 0.11497 0 0 0 0 0 0 0 0 0 0 10.16 0 Q9UHR5 S30BP_HUMAN SAP30-binding protein (Transcriptional regulator protein HCNGP) SAP30BP HCNGP HTRG HTRP Homo sapiens (Human) modulation by host of symbiont transcription [GO:0052472]; regulation of DNA-templated transcription [GO:0006355]; response to virus [GO:0009615] intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IEMDKLEK 1 2.6 0.91407 -0.33804 0 0 0 0 0 0 0 0 9.96939 0 0 0 Q9UHT4 YG001_HUMAN Putative uncharacterized protein PRO1854 PRO1854 Homo sapiens (Human) HHFKIHVPSQFFILITITKY 1 29.9 0.85196 -0.079704 0 0 0 0 0 0 0 0 0 0 4.09803 0 Q9UHV5 RPGFL_HUMAN Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII) RAPGEFL1 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186]; nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265] membrane [GO:0016020]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] FENLTDPCRNHKSYR;LSASVQDILGSVTEKLQYSEEPAGR;QFQVIDNQNLLFELSYKLEANSQ 3 9.5 0.73352 0.11909 0 0 0 0 0 0 0 3.24416 0 0 8.94907 0 Q9UHV7 MED13_HUMAN Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) MED13 ARC250 KIAA0593 THRAP1 TRAP240 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328] CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ADVLGVWRRDQRPGR;EIYPQHLK;LPEECIYR;VSVSDDVGMDADSASQR 4 2.2 0.97438 -2.4509 0 0 0 10.7548 0 0 0 0 0 0 0 5.61589 Q9UHV9 PFD2_HUMAN Prefoldin subunit 2 PFDN2 PFD2 HSPC231 Homo sapiens (Human) chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; positive regulation of cytoskeleton organization [GO:0051495]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] SSGSGAGK 1 5.2 0.7459 0.10231 8.52023 7.88185 0 0 0 0 0 9.18324 0 0 5.36061 0 Q9UHW5 GPN3_HUMAN GPN-loop GTPase 3 (ATP-binding domain 1 family member C) GPN3 ATPBD1C AD-009 UNQ1876/PRO4319 Homo sapiens (Human) protein-containing complex [GO:0032991] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EDESSSMFDEYFQECQDE;QLVQQLEQWEFR 2 10.6 0.78523 0.027579 0 4.89293 0 8.55436 0 0 0 0 0 0 0 0 Q9UHW9 S12A6_HUMAN Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) SLC12A6 KCC3 Homo sapiens (Human) angiogenesis [GO:0001525]; cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] metal ion binding [GO:0046872]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] EINNMTVPSK;SGDLKDAQK 2 1.7 0.92074 -0.4371 0 0 0 0 0 0 0 0 0 11.4408 0 0 Q9UHX1 PUF60_HUMAN Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) PUF60 FIR ROBPI SIAHBP1 Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; apoptotic process [GO:0006915]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cell junction [GO:0030054]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] DIDDDLEGEVTEECGKFGAVNRVIIYQEK;MENGQSTAAK;QAFAPFGPIK 3 8.8 0.91675 -0.414 8.67373 0 0 0 0 0 0 11.4516 12.0684 0 10.9001 0 Q9UHX3 AGRE2_HUMAN Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312) ADGRE2 EMR2 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; regulation of mast cell degranulation [GO:0043304] leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; G protein-coupled receptor activity [GO:0004930] GCARWCPQDSSCVNATACR;LKPEDPKLCTDVDECSSGQHQCDSSTVCFNTVGSYSCR;WCPQDSSCVNATACR 3 7.4 0.94805 -0.66364 0 0 0 3.22219 0 0 0 0 0 0 9.29032 4.56481 Q9UI08 EVL_HUMAN Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) EVL RNB6 Homo sapiens (Human) actin filament organization [GO:0007015]; actin polymerization or depolymerization [GO:0008154]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124] FAFEEFSEQSICQAR;SPEAKSPLQSQPHSRYR 2 8.2 0.84381 -0.053767 0 0 5.75157 0 6.91097 0 0 0 0 0 0 0 Q9UI09 NDUAC_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (13 kDa differentiation-associated protein) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2) NDUFA12 DAP13 Homo sapiens (Human) aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] YGNKYYEDNK 1 6.9 0.88327 -0.17439 0 6.40915 2.37072 0 0 0 0 0 0 0 0 0 Q9UI10 EI2BD_HUMAN Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) EIF2B4 EIF2BD Homo sapiens (Human) cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] ILQEAWTEGRRFR;KPERQQVPTR 2 4.4 0.98051 -1.659 0 0 0 3.13575 0 0 0 0 0 0 0 0 Q9UI12 VATH_HUMAN V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) ATP6V1H CGI-11 Homo sapiens (Human) endocytosis [GO:0006897]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "enzyme regulator activity [GO:0030234]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" GAVDAAVPTNIIAAKAAEVR;LEWSPVHK;NFLEKSTER 3 7.7 0.97579 -2.2569 0 0 0 0 9.0656 0 0 7.29278 0 0 0 0 Q9UI17 M2GD_HUMAN "Dimethylglycine dehydrogenase, mitochondrial (EC 1.5.8.4) (ME2GLYDH)" DMGDH Homo sapiens (Human) amino-acid betaine catabolic process [GO:0006579]; choline catabolic process [GO:0042426]; choline metabolic process [GO:0019695] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] dimethylglycine dehydrogenase activity [GO:0047865]; electron transfer activity [GO:0009055]; RNA binding [GO:0003723] TNWFEPVGSEYK 1 1.4 0.80818 0.010509 0 0 0 8.07366 0 0 0 0 0 0 0 0 Q9UI26 IPO11_HUMAN Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) IPO11 RANBP11 Homo sapiens (Human) protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] MLALKDPVHTVSLQQFIYEK;NQLLPELQVIHNRYKPLRR 2 4 0.96448 -1.1752 0 0 0 0 0 0 0 0 0 0 0 8.34758 Q9UI30 TR112_HUMAN Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) TRMT112 AD-001 HSPC152 HSPC170 Homo sapiens (Human) maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]; rRNA methylation [GO:0031167]; transcription initiation-coupled chromatin remodeling [GO:0045815]; tRNA methylation [GO:0030488] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; tRNA (m2G10) methyltransferase complex [GO:0043528] protein heterodimerization activity [GO:0046982]; protein methyltransferase activity [GO:0008276]; tRNA methyltransferase activator activity [GO:0141106] ICPVEFNPNFVARMIPK 1 13.6 0.94444 -0.62636 0 0 0 0 0 0 0 0 0 0 9.47198 0 Q9UI32 GLSL_HUMAN "Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)" GLS2 GA Homo sapiens (Human) amino acid metabolic process [GO:0006520]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] glutaminase activity [GO:0004359] DCMSEMHR;FLIEACKVNPFAKDR 2 3.8 0.93269 -0.51381 0 0 0 0 0 0 0 9.81561 0 0 0 0 Q9UI33 SCNBA_HUMAN Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN) SCN11A SCN12A SNS2 Homo sapiens (Human) action potential initiation [GO:0099610]; acute inflammatory response [GO:0002526]; artery development [GO:0060840]; axonogenesis [GO:0007409]; behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transmembrane transport [GO:0070588]; cAMP/PKA signal transduction [GO:0141156]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell motility [GO:0048870]; cellular response to cold [GO:0070417]; chronic inflammatory response [GO:0002544]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; mast cell degranulation [GO:0043303]; membrane depolarization during action potential [GO:0086010]; micturition [GO:0060073]; neuronal action potential [GO:0019228]; reflex [GO:0060004]; response to auditory stimulus [GO:0010996]; response to heat [GO:0009408]; response to high light intensity [GO:0009644]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of itch [GO:0160025]; sensory perception of pain [GO:0019233]; skeletal muscle organ development [GO:0060538]; small intestine smooth muscle contraction [GO:1990770]; sodium ion transmembrane transport [GO:0035725]; thermosensory behavior [GO:0040040]; thigmotaxis [GO:0001966] axon [GO:0030424]; axonal growth cone [GO:0044295]; C-fiber [GO:0044299]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] ASRKLPK;KLGSKKPQKPIPRPLNK;KSDVTSILSECSTIDLQDGFGWLPEMVPKK;LKVIVGALLRSVK;VLRTVMTDPFTELAITICIIINTVFLAMEHHK 5 5.5 0.80559 0.013984 0 8.39862 8.8853 0 0 8.08417 2.7845 0 10.4425 0 0 0 Q9UI38 TSP50_HUMAN Probable threonine protease PRSS50 (EC 3.4.25.-) (Cancer/testis antigen 20) (Serine protease 50) (Testis-specific protease-like protein 50) PRSS50 CT20 TSP50 Homo sapiens (Human) proteolysis [GO:0006508] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783] serine-type endopeptidase activity [GO:0004252]; threonine-type endopeptidase activity [GO:0004298] AGALLLLLLLLR;TLLLALPLPLSLLAAL;TSAPSRAGALLLLLLLLR 3 8.8 0.91694 -0.41255 0 0 3.23136 4.86765 0 3.2454 3.24109 0 0 3.4593 0 0 Q9UI40 NCKX2_HUMAN Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) SLC24A2 NCKX2 Homo sapiens (Human) calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725] photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] "calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]" QNGAANHVEK;TLLDLNDK 2 2.7 0.93695 -0.55403 0 11.5695 0 0 0 9.83026 0 0 0 0 0 0 Q9UI43 MRM2_HUMAN "rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)" MRM2 FJH1 FTSJ2 Homo sapiens (Human) mitochondrial large ribosomal subunit assembly [GO:1902775]; RNA methylation [GO:0001510]; rRNA 2'-O-methylation [GO:0000451]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650] VESYRCRSAFK 1 4.5 0.86591 -0.088746 0 0 0 0 9.50696 0 0 0 0 0 0 0 Q9UI46 DNAI1_HUMAN Dynein axonemal intermediate chain 1 (Axonemal dynein intermediate chain 1) DNAI1 Homo sapiens (Human) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; microtubule [GO:0005874]; outer dynein arm [GO:0036157] cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] IVSWTLVKRK;LTHVQFNLIHPIIIVGDDR 2 4.1 0.36739 0.22942 0 0 0 0 0 7.54295 0 0 0 4.85554 0 0 Q9UI46 DNAI1_HUMAN Dynein axonemal intermediate chain 1 (Axonemal dynein intermediate chain 1) DNAI1 Homo sapiens (Human) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; microtubule [GO:0005874]; outer dynein arm [GO:0036157] cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] ILTANNPHAPQNIVRYSFKK 1 11.9 0.46422 0.19077 0 0 0 0 0 0 0 0 6.52424 0 0 0 Q9UI72 YE014_HUMAN Putative uncharacterized protein PRO0255 PRO0255 Homo sapiens (Human) GMALELYWLCGFR 1 18.8 0.87428 -0.11803 0 0 0 0 0 0 0 0 0 0 0 10.864 Q9UI95 MD2L2_HUMAN Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7) MAD2L2 MAD2B REV7 Homo sapiens (Human) "actin filament organization [GO:0007015]; cell division [GO:0051301]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; error-prone translesion synthesis [GO:0042276]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of isotype switching [GO:0045830]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cell growth [GO:0001558]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]" chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; zeta DNA polymerase complex [GO:0016035] JUN kinase binding [GO:0008432]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] MQLYVEERAHKGS 1 6.2 0.86513 -0.087613 0 0 8.37565 0 0 0 0 0 0 0 0 0 Q9UIA9 XPO7_HUMAN Exportin-7 (Exp7) (Ran-binding protein 16) XPO7 KIAA0745 RANBP16 Homo sapiens (Human) protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] ALVEFTNSPDCLSK;TTFYTALGR 2 2.1 0.95547 -0.93387 0 0 0 9.28249 0 0 0 0 0 0 0 0 Q9UIB8 SLAF5_HUMAN SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84) CD84 SLAMF5 Homo sapiens (Human) adaptive immune response [GO:0002250]; autophagy [GO:0006914]; defense response [GO:0006952]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of granulocyte macrophage colony-stimulating factor production [GO:0032685]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of mast cell activation [GO:0033004]; negative regulation of mast cell degranulation [GO:0043305]; regulation of store-operated calcium entry [GO:2001256]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] EEPVNTVYSEVQFADK;RYNLQIYRR 2 7.2 0.71218 0.15715 10.0681 9.58616 0 0 0 0 0 0 0 0 0 0 Q9UIC8 LCMT1_HUMAN Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) LCMT1 LCMT CGI-68 Homo sapiens (Human) C-terminal protein methylation [GO:0006481]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of protein-containing complex assembly [GO:0031333]; protein methylation [GO:0006479]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal leucine carboxyl O-methyltransferase activity [GO:0018423]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] METCCSHLGLRSGR;YAVIGADLR 2 6.4 0.95186 -0.68996 0 0 0 0 2.79761 0 0 0 0 0 0 0 Q9UID6 ZN639_HUMAN Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) ZNF639 ZASC1 Homo sapiens (Human) negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; symbiont entry into host cell [GO:0046718] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" CSDCLMRFGNER;LHEEDPYICK 2 4.5 0.91909 -0.43803 0 6.37752 0 0 0 0 0 0 2.64883 0 0 0 Q9UIF3 TEKT2_HUMAN Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] DRAEAEMKAATELR;EVEVIEATKK 2 5.6 0.95495 -0.7964 0 0 13.7427 0 0 0 0 0 0 0 0 0 Q9UIF7 MUTYH_HUMAN Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH) MUTYH MYH Homo sapiens (Human) base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; negative regulation of necroptotic process [GO:0060546] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; DNA N-glycosylase activity [GO:0019104]; metal ion binding [GO:0046872]; MutSalpha complex binding [GO:0032407]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]" ASRKPPR;MGQQVLDNFFR 2 3.3 0.91551 -0.3965 0 0 0 7.08012 5.98759 0 0 0 0 5.15826 0 0 Q9UIF8 BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) chromatin remodeling [GO:0006338]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AESVQIK;ALLKVLHLRGIR;ETRIRNFGGR;GGDSDYDDDDDDDSDDQGDEDDEDEEDK;GGDSDYDDDDDDDSDDQGDEDDEDEEDKEDKK;KLQAQEIAR;LQGEVAYYAPCGKK;LRQYPEVIKYLSR;QESFTSVKKPK;SNNQVLLHGISDPK;VTDERELR 11 6 0.97562 -3.3282 9.71565 0 0 9.8194 6.02556 3.49083 7.93475 11.8211 0 8.50498 9.40996 7.26021 Q9UIF9 BAZ2A_HUMAN Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) BAZ2A KIAA0314 TIP5 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase I [GO:0016479]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA-templated transcription [GO:0006355]; RNA polymerase I preinitiation complex assembly [GO:0001188] chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; NoRC complex [GO:0090536]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553] DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723] QLPAFQEGIMSWSPK;TKPGSMQPRHLKSPVR;TTNPLDLAVMRLAALEQNVERR;VKITELLNKTDNRPLK;VTCLVCR;VWRQTLERCR 6 4.5 0.97772 -1.5189 0 8.0926 0 0 6.57749 0 0 8.47391 7.51357 0 8.6726 0 Q9UIG0 BAZ1B_HUMAN Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of mitotic chromosome condensation [GO:1905213]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; post-translational protein modification [GO:0043687]; regulation of transcription by RNA polymerase II [GO:0006357] B-WICH complex [GO:0110016]; condensed chromosome [GO:0000793]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; WICH complex [GO:0090535] ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; histone kinase activity [GO:0035173]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; zinc ion binding [GO:0008270] ANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQK;ELDELLNCLHPQGIR;KGPPAKKPGK;KPNLGLK;MLKVKIVK;NSGGTPR;NSKNSKSPEEHLEEMMK;SLVQKRYELLEHK;SPEEHLEEMMK;TKMKQMTLLDMAK;VASALEK;WAPPKFLPHK 12 9.9 0.97607 -5.2543 0 10.0197 10.3964 0 0 6.95652 3.01808 0 0 11.4267 9.46901 8.56266 Q9UIG8 SO3A1_HUMAN Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) SLCO3A1 OATP3A1 OATPD SLC21A11 Homo sapiens (Human) monoatomic ion transport [GO:0006811]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] SFAFILYTTTWQCLR;TVSPELK 2 3.1 0.91052 -0.29184 0 0 0 0 8.92899 0 0 0 0 8.1353 0 0 Q9UIH9 KLF15_HUMAN Krueppel-like factor 15 (Kidney-enriched krueppel-like factor) KLF15 KKLF Homo sapiens (Human) cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to peptide [GO:1901653]; glial cell differentiation [GO:0010001]; intracellular glucose homeostasis [GO:0001678]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; podocyte differentiation [GO:0072112]; positive regulation of D-glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; response to insulin [GO:0032868] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" CTFPGCSKMYTK;VDHLLPVDENFSSPK 2 6.5 0.95518 -0.83217 0 0 15.0757 11.8635 7.69648 11.9942 0 0 0 0 0 8.10784 Q9UII4 HERC5_HUMAN E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) HERC5 CEB1 CEBP1 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; PKR/eIFalpha signaling [GO:0039585]; protein ubiquitination [GO:0016567]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of defense response to virus [GO:0050688]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] ISG15 transferase activity [GO:0042296]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] AVYEEFRR;DLNNMKITFCCPESWNER;LFHPEELK;MCDEDIIK 4 4.1 0.95896 -1.0338 0 9.31895 12.096 11.4125 9.83898 0 0 0 0 0 0 0 Q9UII5 ZN107_HUMAN Zinc finger protein 107 (Zinc finger protein 588) (Zinc finger protein ZFD25) ZNF107 ZFD25 ZNF588 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNQSSQLTR;HVDECTGHK;ILHTGENLYKCK 3 4 0.97057 -1.3345 0 0 0 0 0 0 0 0 11.8402 0 6.63174 0 Q9UII6 DS13B_HUMAN Dual specificity protein phosphatase 13B (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP4) (Testis- and skeletal-muscle-specific DSP) DUSP13B DUSP13 SKRP4 TMDP Homo sapiens (Human) dephosphorylation [GO:0016311]; meiotic cell cycle [GO:0051321]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" HQAHILVPLKIQLRR;PQVGGRPLSHLER;PQVGGRPLSHLERSQWGMR 3 10.2 0.95415 -0.91503 0 0 0 7.45352 0 0 0 8.18631 0 0 0 0 Q9UIK4 DAPK2_HUMAN Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) DAPK2 Homo sapiens (Human) anoikis [GO:0043276]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of eosinophil chemotaxis [GO:2000424]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242] autophagosome lumen [GO:0034423]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LTIQEALR;TEPTQLK;TEPTQLKTKHLR 3 4.1 0.88617 -0.18063 0 0 0 0 0 0 0 0 9.81223 5.77547 0 0 Q9UIK5 TEFF2_HUMAN Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains) TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204 Homo sapiens (Human) "cell differentiation [GO:0030154]; negative regulation of cell migration [GO:0030336]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of stress fiber assembly [GO:0051497]; wound healing, spreading of cells [GO:0044319]" extracellular region [GO:0005576]; membrane [GO:0016020] SYDNACQIK 1 2.4 0.84583 -0.058252 0 0 0 0 0 0 0 8.31719 7.81615 0 0 0 Q9UIL4 KIF25_HUMAN Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) establishment of spindle orientation [GO:0051294]; microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; negative regulation of mitotic centrosome separation [GO:0046603]; nucleus localization [GO:0051647]; organelle organization [GO:0006996]; protein homotetramerization [GO:0051289] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] EQTEAGR 1 1.8 0.91294 -0.32242 0 0 0 0 0 0 0 0 5.68622 0 0 0 Q9UIM3 FKBPL_HUMAN FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39) (WISp39) FKBPL DIR1 NG7 Homo sapiens (Human) regulation of blood vessel branching [GO:1905553]; response to radiation [GO:0009314] cytosol [GO:0005829]; extracellular region [GO:0005576] EERARGTELFR;KIVIRGHGLDKPK;VLAIDPKNR;VLEREPGHLK 4 12.3 0.97492 -3.075 15.4745 0 0 0 0 0 0 0 0 0 4.12002 0 Q9UIQ6 LCAP_HUMAN "Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]" LNPEP OTASE Homo sapiens (Human) "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; negative regulation of cold-induced thermogenesis [GO:0120163]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]" cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome lumen [GO:0031905]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] EPCLHPLEPDEVEYEPR;ILEALASSEDVRKLYWLMK;LLGMSFMNR;LPTAVVPLR;TQKLSFIIRTVGR 5 6.5 0.97498 -2.3551 0 0 9.73912 0 0 6.04915 11.3838 0 0 0 0 8.28697 Q9UIR0 BTNL2_HUMAN Butyrophilin-like protein 2 (BTL-II) BTNL2 Homo sapiens (Human) negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] GEKLLAVSEHR;GWFPEPQVYWEDIRGEK;TLLVWGLLLAVAVGLPRKR 3 9.1 0.91636 -0.43319 0 0 0 0 0 4.01498 2.69693 0 0 9.74482 6.53526 0 Q9UIS9 MBD1_HUMAN Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) MBD1 CXXC3 PCM1 Homo sapiens (Human) epigenetic regulation of gene expression [GO:0040029]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron differentiation [GO:0030182]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]; ventricular cardiac muscle tissue development [GO:0003229] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; methyl-CpG binding [GO:0008327]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] CGACAACLRR;FGGSNQK;FGGSNQKR;MDCGRCDFCCDKPK;MFKSRGCGVCR;YLGPACDLTLFDFK 6 10.3 0.9534 -0.78271 12.0595 0 6.6317 9.72288 0 6.60581 11.9352 0 0 0 0 9.06509 Q9UIU6 SIX4_HUMAN Homeobox protein SIX4 (Sine oculis homeobox homolog 4) SIX4 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; embryonic cranial skeleton morphogenesis [GO:0048701]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" YPSPAEK 1 0.9 0.90892 -0.31607 0 0 0 0 0 0 7.24317 0 0 0 0 0 Q9UIV8 SPB13_HUMAN Serpin B13 (HaCaT UV-repressible serpin) (Hurpin) (Headpin) (Peptidase inhibitor 13) (PI-13) (Proteinase inhibitor 13) SERPINB13 PI13 Homo sapiens (Human) negative regulation of endopeptidase activity [GO:0010951]; negative regulation of keratinocyte apoptotic process [GO:1902173]; regulation of proteolysis [GO:0030162]; response to UV [GO:0009411] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] KINSWVESKTNEK;LVEWTSPGHMEERK 2 6.9 0.88613 -0.19597 0 0 11.7199 3.19991 0 0 0 0 0 9.16234 0 0 Q9UIW2 PLXA1_HUMAN Plexin-A1 (Semaphorin receptor NOV) PLXNA1 NOV PLXN1 Homo sapiens (Human) dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of cell adhesion [GO:0007162]; neuron projection extension [GO:1990138]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] IPSDTLSK;MLTNWFTFLLYK;SEYFPTLSSRR;TESVAEK;VKPPKESALCLFTLRAIK 5 3 0.96729 -1.3064 13.2612 0 0 0 8.26397 0 11.3363 9.22887 0 0 0 0 Q9UIX4 KCNG1_HUMAN Voltage-gated potassium channel regulatory subunit KCNG1 (Potassium voltage-gated channel subfamily G member 1) (Voltage-gated potassium channel subunit Kv6.1) (kH2) KCNG1 Homo sapiens (Human) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] QEQERVMFR;RKPGAGNSYLDKVGLVLR;VGLVLRVLRALR;VLRALRILYVMR 4 7.6 0.97482 -3.1934 7.72062 9.46338 9.60043 2.90993 0 0 4.61235 11.5567 0 0 0 0 Q9UIY3 RWD2A_HUMAN RWD domain-containing protein 2A RWDD2A RWDD2 Homo sapiens (Human) YLEGTREALPPKIEFVITLQIEEPK 1 8.6 0.66254 0.16893 0 0 0 6.63749 0 0 0 0 0 0 0 0 Q9UJ04 TSYL4_HUMAN Testis-specific Y-encoded-like protein 4 (TSPY-like protein 4) TSPYL4 KIAA0721 Homo sapiens (Human) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] GELWPNPLQYYLMGEGPR;GLEAASAAEAADSSQK;NEGLVKEYER;VVSLSTPIR 4 12.8 0.97271 -2.6711 0 0 0 0 0 0 13.2682 0 0 0 0 0 Q9UJ41 RABX5_HUMAN Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5) RABGEF1 RABEX5 Homo sapiens (Human) dendritic transport [GO:0098935]; Kit signaling pathway [GO:0038109]; mast cell degranulation [GO:0043303]; mast cell migration [GO:0097531]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mast cell activation [GO:0033004]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of receptor-mediated endocytosis [GO:0048261]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; Ras protein signal transduction [GO:0007265]; receptor-mediated endocytosis [GO:0006898]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368] cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; nucleolus [GO:0005730]; presynaptic endosome [GO:0098830]; recycling endosome [GO:0055037] DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CSKHIFNAIK;EVQDIVEK;IMDQIEKYIMTRLYK;LACITKCSK;QKQIQEDWELAER 5 10.6 0.97497 -1.3837 0 0 0 9.1098 0 3.85669 3.82293 0 0 10.6934 9.6893 10.7469 Q9UJ42 GP160_HUMAN Probable G-protein coupled receptor 160 (G-protein coupled receptor GPCR1) (hGPCR1) GPR160 GPCR150 Homo sapiens (Human) plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] ILLNILTLGMRR 1 3.6 0.36105 0.23223 0 4.59616 0 0 0 0 0 0 0 0 0 0 Q9UJ55 MAGL2_HUMAN MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) MAGEL2 NDNL1 Homo sapiens (Human) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin nucleation [GO:0051127]; protein K63-linked ubiquitination [GO:0070534]; regulation of circadian rhythm [GO:0042752]; retrograde transport, endosome to Golgi [GO:0042147]; rhythmic process [GO:0048511]" cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; nucleus [GO:0005634] ubiquitin-protein transferase activity [GO:0004842] EDLIFNFLFK 1 0.8 0.89599 -0.23669 7.10161 0 0 0 0 0 0 0 0 0 0 0 Q9UJ71 CLC4K_HUMAN C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) CD207 CLEC4K Homo sapiens (Human) defense response to virus [GO:0051607]; immune response [GO:0006955] clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187] NSHLTSVTSESEQEFLYK;QNISLWPREPPPK 2 9.5 0.97378 -1.3961 0 4.97384 4.70022 0 0 0 0 0 11.8789 0 0 0 Q9UJ72 ANX10_HUMAN Annexin A10 (Annexin-10) (Annexin-14) ANXA10 ANX14 Homo sapiens (Human) cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786] SLFHDIRNFASGHYK 1 4.6 0.91685 -0.42899 0 0 0 0 0 0 0 0 0 9.38232 0 0 Q9UJ78 ZMYM5_HUMAN Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) ZMYM5 ZNF198L1 ZNF237 HSPC050 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] zinc ion binding [GO:0008270] FCCQSCINEYK;FSETYYTR 2 2.8 0.93763 -0.57577 0 0 0 0 0 0 0 0 0 0 3.43389 0 Q9UJ78 ZMYM5_HUMAN Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) ZMYM5 ZNF198L1 ZNF237 HSPC050 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] zinc ion binding [GO:0008270] LAEVWIFIPKLLFRLTVIILTFK 1 6 0.59621 0.17852 0 0 0 0 0 0 0 0 0 0 9.49277 0 Q9UJ83 HACL1_HUMAN 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) HACL1 HPCL HPCL2 PHYH2 HSPC279 Homo sapiens (Human) fatty acid alpha-oxidation [GO:0001561]; fatty acid metabolic process [GO:0006631]; methyl-branched fatty acid metabolic process [GO:0097089]; phytanic acid metabolic process [GO:1903512]; protein targeting to peroxisome [GO:0006625] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] 2-hydroxyacyl-CoA lyase activity [GO:0106359]; 2-hydroxyphytanoyl-CoA lyase activity [GO:0106376]; ATP binding [GO:0005524]; carbon-carbon lyase activity [GO:0016830]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] QPLLIIGK 1 1.4 0.74633 0.10231 0 0 0 4.24869 0 0 0 0 0 0 0 0 Q9UJ99 CAD22_HUMAN Cadherin-22 (Pituitary and brain cadherin) (PB-cadherin) CDH22 C20orf25 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] LLEPESEFIIK;RPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGR 2 5.4 0.88083 -0.14759 0 0 0 0 0 4.13693 0 13.3066 0 0 0 0 Q9UJA5 TRM6_HUMAN tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) TRMT6 KIAA1153 TRM6 CGI-09 Homo sapiens (Human) mRNA processing [GO:0006397]; tRNA methylation [GO:0030488] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] RNA binding [GO:0003723] LSETWLR;NIVDDGK;SHPKLLMSGGGGYLLSGFTVAMDNLK 3 8 0.94168 -0.61353 0 10.7602 0 0 0 0 8.88062 0 0 0 0 9.47458 Q9UJC3 HOOK1_HUMAN Protein Hook homolog 1 (h-hook1) (hHK1) HOOK1 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centrosome [GO:0005813]; cytoplasm [GO:0005737]; FHF complex [GO:0070695]; microtubule [GO:0005874] actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] LQDLNDLRK;MEETQPPPQPK;SYENLAAEIMPVEYREVFIR 3 5.5 0.95584 -0.98635 0 0 11.1937 0 0 9.29386 0 9.46734 0 0 0 0 Q9UJC3 HOOK1_HUMAN Protein Hook homolog 1 (h-hook1) (hHK1) HOOK1 Homo sapiens (Human) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centrosome [GO:0005813]; cytoplasm [GO:0005737]; FHF complex [GO:0070695]; microtubule [GO:0005874] actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] AQVLHQIDAAWFNESWLSR;LQDLNDLRK;SYENLAAEIMPVEYREVFIR 3 7 0.78356 0.023899 6.34101 0 0 0 0 0 0 8.07532 7.78686 0 0 0 Q9UJD0 RIMS3_HUMAN Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) RIMS3 KIAA0237 Homo sapiens (Human) calcium-ion regulated exocytosis [GO:0017156]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082] presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; transmembrane transporter binding [GO:0044325] GLTPKPGSK 1 2.9 0.91045 -0.31648 0 0 0 7.12897 0 0 0 0 0 0 0 0 Q9UJF2 NGAP_HUMAN Ras GTPase-activating protein nGAP (RAS protein activator-like 2) RASAL2 NGAP Homo sapiens (Human) adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] EVFASWKQQCLNR;GENSFLQATVAK;LDRNTSFR;QTPEVPAERSPR 4 4 0.97544 -3.343 0 0 0 0 0 9.81874 0 0 0 0 10.4234 0 Q9UJF2 NGAP_HUMAN Ras GTPase-activating protein nGAP (RAS protein activator-like 2) RASAL2 NGAP Homo sapiens (Human) adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] EIPVEGGQEQQTDSTK;EVFASWKQQCLNR;LDRNTSFR 3 2.9 0.78477 0.029028 0 0 0 0 0 5.20109 0 0 0 0 0 0 Q9UJG1 MSPD1_HUMAN Motile sperm domain-containing protein 1 MOSPD1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] LQVSEQSQR 1 4.2 0.92396 -0.44887 0 0 0 0 0 0 0 0 0 13.5981 0 0 Q9UJJ7 RUSD1_HUMAN RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein) RPUSD1 C16orf40 RLUCL Homo sapiens (Human) enzyme-directed rRNA pseudouridine synthesis [GO:0000455] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] VLLKPLTGRTHQLR;VTISHAIGR 2 7.4 0.95214 -0.74421 0 0 0 0 0 0 0 0 3.54683 0 0 9.22725 Q9UJJ9 GNPTG_HUMAN N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) GNPTG C16orf27 GNPTAG CAB56184 LP2537 Homo sapiens (Human) carbohydrate phosphorylation [GO:0046835]; N-glycan processing to lysosome [GO:0016256] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex [GO:0070622] protein homodimerization activity [GO:0042803]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] TPEENEPTQLEGGPDSLGFETLENCR 1 8.5 0.71124 0.14778 0 0 0 6.67807 0 0 0 0 0 0 0 0 Q9UJL9 ZF69B_HUMAN Zinc finger protein 69 homolog B (Zinc finger protein 643) ZFP69B ZNF643 Homo sapiens (Human) Golgi organization [GO:0007030]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AATERVALWEDVTK;LESQQENQR;QLIHLTEHMRIHTGEKPFR 3 7.9 0.95516 -0.88295 0 0 8.80071 0 0 0 0 0 0 0 6.03307 0 Q9UJM3 ERRFI_HUMAN ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) ERRFI1 MIG6 Homo sapiens (Human) apoptotic process [GO:0006915]; bile acid biosynthetic process [GO:0006699]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chondrocyte proliferation [GO:0035988]; embryo implantation [GO:0007566]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; fat pad development [GO:0060613]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; limb joint morphogenesis [GO:0036022]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; lung epithelium development [GO:0060428]; lung vasculature development [GO:0060426]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of protein autophosphorylation [GO:0031953]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; progesterone receptor signaling pathway [GO:0050847]; protein localization to plasma membrane [GO:0072659]; regulation of keratinocyte differentiation [GO:0045616]; response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904565]; response to estradiol [GO:0032355]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; tissue homeostasis [GO:0001894]; uterine epithelium development [GO:0035847] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901] VPCILPIIENGKK 1 2.8 0.66744 0.16868 0 0 0 0 0 0 0 0 0 8.61032 0 0 Q9UJM8 HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GO) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5) HAO1 GOX1 Homo sapiens (Human) fatty acid alpha-oxidation [GO:0001561]; glycine biosynthetic process [GO:0006545]; glycolate catabolic process [GO:0046296]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782] (S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]; glyoxylate oxidase activity [GO:0047969] ALALGAK;LICINDYEQHAK;VEVFLDGGVRKGTDVLK 3 9.7 0.7458 0.10027 0 13.6273 7.46361 7.55842 0 0 0 0 0 0 0 0 Q9UJN7 ZN391_HUMAN Zinc finger protein 391 ZNF391 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KSSFENTVVR;STNLSQHQR 2 5.3 0.93394 -0.49822 0 0 0 0 0 0 0 0 0 2.85248 7.80394 0 Q9UJP4 KLH21_HUMAN Kelch-like protein 21 KLHL21 KIAA0469 Homo sapiens (Human) cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; polar microtubule [GO:0005827] cullin family protein binding [GO:0097602]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LPLARLLRYLR 1 1.8 0.77097 0.052918 0 9.3466 0 0 0 0 0 0 0 0 0 0 Q9UJQ1 LAMP5_HUMAN Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5) LAMP5 C20orf103 Homo sapiens (Human) establishment of protein localization to organelle [GO:0072594]; presynaptic modulation of chemical synaptic transmission [GO:0099171] cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; GABA-ergic synapse [GO:0098982]; growth cone membrane [GO:0032584]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672] DLQGRGVPSIDR;LSKVQFVYDSSEKTHFK;SYECQAQQTISLASSDPQK 3 17.1 0.95521 -0.81718 0 16.1925 7.01981 0 0 0 0 0 0 8.67867 0 0 Q9UJQ4 SALL4_HUMAN Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4) SALL4 ZNF797 Homo sapiens (Human) embryonic limb morphogenesis [GO:0030326]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; ventricular septum development [GO:0003281] cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTTKGNLKVHFHR;GNLKVHFHRHPQVK 2 1.7 0.73318 0.11892 0 0 0 0 8.6627 7.54813 0 0 0 0 0 0 Q9UJQ7 SCP2D_HUMAN SCP2 sterol-binding domain-containing protein 1 SCP2D1 C20orf79 Homo sapiens (Human) cytosol [GO:0005829] VLLSWKLER 1 5.8 0.96777 -1.3231 0 0 0 0 0 0 0 0 10.8768 0 0 0 Q9UJS0 S2513_HUMAN "Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (Calcium-binding mitochondrial carrier protein Aralar2) (ARALAR-related gene 2) (ARALAR2) (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13)" SLC25A13 Homo sapiens (Human) aspartate transmembrane transport [GO:0015810]; ATP biosynthetic process [GO:0006754]; cellular respiration [GO:0045333]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; mitochondrial transport [GO:0006839]; response to calcium ion [GO:0051592] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] "3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]" FGQVTPMEVDILFQLADLYEPR;IAPLEEGTLPFNLAEAQR;LTVNDFVR;LTVNDFVRDK;TGRVTAIDFR 5 8.9 0.97863 -2.0836 14.6593 11.5021 11.8084 10.0139 0 0 7.56932 0 0 0 6.37596 11.3494 Q9UJT2 TSKS_HUMAN Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1) TSKS STK22S1 TSKS1 Homo sapiens (Human) centriole [GO:0005814]; cytoplasm [GO:0005737] protein kinase binding [GO:0019901] AGEGPYVSEQELQK;AGEGPYVSEQELQKLFTGIEELRR;CASQGSQLSTESLQQLLDR;RQEAELQEPEEK;WHQEEGAVQEALRLLGGLGGR 5 12.8 0.91096 -0.32057 11.6831 0 0 8.08119 0 3.96421 0 0 10.6559 5.56078 0 0 Q9UJT9 FBXL7_HUMAN F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ELSVSDCRFVSDFGLR;FVSDFGLREIAK;LTGETINVDR 3 6.1 0.95415 -0.90334 0 0 0 0 0 0 0 10.534 0 0 10.8022 0 Q9UJU2 LEF1_HUMAN Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) LEF1 Homo sapiens (Human) anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell proliferation [GO:0042100]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-4 [GO:0071353]; chorio-allantoic fusion [GO:0060710]; dentate gyrus development [GO:0021542]; embryonic limb morphogenesis [GO:0030326]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; face morphogenesis [GO:0060325]; forebrain neuroblast division [GO:0021873]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; mammary gland development [GO:0030879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil differentiation [GO:0030223]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; paraxial mesoderm formation [GO:0048341]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell cycle process [GO:0090068]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to chromatin [GO:0071168]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary palate development [GO:0062009]; sensory perception of taste [GO:0050909]; somitogenesis [GO:0001756]; sprouting angiogenesis [GO:0002040]; T cell receptor V(D)J recombination [GO:0033153]; T-helper 1 cell differentiation [GO:0045063]; tongue development [GO:0043586]; trachea gland development [GO:0061153]; transcription by RNA polymerase II [GO:0006366] beta-catenin-TCF complex [GO:1990907]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; gamma-catenin binding [GO:0045295]; histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]" AREHPDDGK;IFAEISHPEEEGDLADIK 2 6.8 0.89719 -0.24763 0 0 0 0 0 0 0 0 9.05805 0 6.53208 0 Q9UJU3 ZN112_HUMAN Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AYLQGHQRVHTR;ENYSCHDCGEDIMK;ESHNYQCR;SNLQAHQR;VHTGEKPYKCEECGKGFSR 5 8.8 0.98073 -1.613 0 0 0 0 0 0 8.80265 0 0 8.24308 0 0 Q9UJU6 DBNL_HUMAN Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) DBNL CMAP SH3P7 PP5423 Homo sapiens (Human) adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; membrane organization [GO:0061024]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; synapse assembly [GO:0007416] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] DPNSGLPK;DSFWAKAEKEEENR;EPAAAISRPR;NGPALQEAYVR;RAEEAQR;VGKDSFWAK 6 12.3 0.97919 -1.9 12.5759 0 0 8.65019 9.98428 0 10.6687 0 10.8451 4.82812 0 10.5683 Q9UJV3 TRIM1_HUMAN Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] AINQAGSR;LAQQVANCR;LDPKMTHKK;TCITCEVSYCDRCLR;TNSQPFKLDPKMTHK 5 6.5 0.9296 -0.46686 0 0 15.1068 11.6914 12.1495 12.2957 0 8.70529 0 1.86715 0 0 Q9UJV8 PURG_HUMAN Purine-rich element-binding protein gamma (Purine-rich element-binding protein G) PURG Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; synapse [GO:0045202] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ENINLFHCCQIKHK;KYYLDLKENQR;RGGGGGR 3 9.9 0.91338 -0.38159 0 0 0 9.48174 0 0 3.1117 0 0 0 0 9.4746 Q9UJV9 DDX41_HUMAN Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) DDX41 ABS Homo sapiens (Human) "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cGAS/STING signaling pathway [GO:0140896]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ITDCPKLEAMQTK 1 2.1 0.92145 -0.44571 0 0 0 0 8.22526 0 0 0 0 0 0 0 Q9UJW0 DCTN4_HUMAN Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) DCTN4 Homo sapiens (Human) cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleus [GO:0005634]; sarcomere [GO:0030017]; spindle pole [GO:0000922]; stress fiber [GO:0001725] APLSQLYFCR;AYYLACGFCRWTSR 2 5.2 0.97981 -1.84 0 0 10.5479 0 8.26842 0 0 0 0 9.80171 0 0 Q9UJW2 TINAG_HUMAN Tubulointerstitial nephritis antigen (TIN-Ag) TINAG Homo sapiens (Human) cell adhesion [GO:0007155]; proteolysis [GO:0006508] basement membrane [GO:0005604]; extracellular space [GO:0005615] cysteine-type endopeptidase activity [GO:0004197]; nucleotide binding [GO:0000166] ENSDCCPDYKSFCR;SFCREEK 2 3.6 0.95138 -0.71592 0 0 0 0 5.146 0 0 0 0 0 6.83289 0 Q9UJW3 DNM3L_HUMAN DNA (cytosine-5)-methyltransferase 3-like DNMT3L Homo sapiens (Human) "autosome genomic imprinting [GO:0141068]; chorionic trophoblast cell differentiation [GO:0060718]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; epigenetic programing of female pronucleus [GO:0044726]; genomic imprinting [GO:0071514]; male meiosis I [GO:0007141]; methylation [GO:0032259]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta development [GO:0001890]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]" catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleus [GO:0005634] "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]" CYCFECVDSLVGPGTSGK 1 4.7 0.67517 0.16628 0 0 0 0 0 0 0 0 0 0 0 5.59816 Q9UJW7 ZN229_HUMAN Zinc finger protein 229 ZNF229 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CDVCGKGFR;NLDTEDTVYK;SVKSLERGR 3 3.4 0.97494 -3.6962 0 0 0 12.6252 0 0 0 0 0 11.4046 0 0 Q9UJW8 ZN180_HUMAN Zinc finger protein 180 (HHZ168) ZNF180 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AVIHERVCK;FTRDDPWLSSCEEVDDCK;IFDEEPANGVKIERFTR;ISHNEQQRIPFEESQYK;TLDRDVILENHR 5 10.1 0.97544 -3.399 0 0 0 0 0 0 0 0 0 9.04319 0 8.03243 Q9UJW9 SRTD3_HUMAN SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator) SERTAD3 RBT1 Homo sapiens (Human) negative regulation of cell growth [GO:0030308]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] WEWSPAGLQSYQQALLRISLDK 1 11.2 0.82853 -0.025381 0 0 0 0 0 0 0 0 0 0 6.85175 0 Q9UJX0 OSGI1_HUMAN "Oxidative stress-induced growth inhibitor 1 (Bone marrow stromal cell-derived growth inhibitor) (BMSC-derived growth inhibitor) (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)" OSGIN1 BDGI OKL38 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308] growth factor activity [GO:0008083] SLPRHQLLCFK 1 2.3 0.94457 -0.64648 0 0 4.33807 0 9.33098 0 0 0 0 0 0 0 Q9UJX2 CDC23_HUMAN Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) CDC23 ANAPC8 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin-protein transferase activity [GO:0004842] EYDRAAHFLHGCNSKK;GLLHSSK 2 3.9 0.98069 -1.6186 0 0 0 0 0 0 11.0639 0 0 0 9.47328 0 Q9UJX3 APC7_HUMAN Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) ANAPC7 APC7 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; brain development [GO:0007420]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903] YKMAECYTMLKQDK 1 2.5 0.58638 0.17975 0 0 0 0 8.27561 0 0 0 0 0 0 0 Q9UJX4 APC5_HUMAN Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) ANAPC5 APC5 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] protein phosphatase binding [GO:0019903] DVVYFQAR;LLQKLLVHCQK;TGEGAVSLMER;VDCKERIR 4 5 0.97837 -2.0609 0 7.41752 4.25263 0 0 0 0 0 9.26714 0 9.02223 0 Q9UJX5 APC4_HUMAN Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) ANAPC4 APC4 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein phosphatase binding [GO:0019903]; ubiquitin-protein transferase activity [GO:0004842] AQYVAGNGFR;ESPLLFPYYPRKSLHFVK;LFKFPFLWNNK 3 4.8 0.95274 -0.76617 0 0 0 0 0 9.37032 0 0 12.2389 0 7.78562 0 Q9UJX6 ANC2_HUMAN Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) ANAPC2 APC2 KIAA1406 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase binding [GO:0031625] AVKMPVALLR;DSRPAIEDLK;LEVPEDIRAALEAYCKK;MPVALLRR;WRCHVQR 5 5.5 0.97568 -3.3214 0 11.2533 0 10.5997 0 0 7.09772 0 0 0 9.697 0 Q9UJY4 GGA2_HUMAN "ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)" GGA2 KIAA1080 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] IQSPQEK;NLVKEEQEKSEK 2 3.1 0.91151 -0.32402 0 0 7.80239 0 0 0 0 7.41616 0 0 0 0 Q9UJY5 GGA1_HUMAN "ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)" GGA1 Homo sapiens (Human) "Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to ciliary membrane [GO:1903441]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] EMVQEDQKRMEK;ILFHFAR;VLETCMKSCGKR 3 4.7 0.978 -2.1537 0 0 9.68643 0 0 0 0 0 0 0 0 10.0541 Q9UJZ1 STML2_HUMAN "Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)" STOML2 SLP2 HSPC108 Homo sapiens (Human) "CD4-positive, alpha-beta T cell activation [GO:0035710]; intracellular calcium ion homeostasis [GO:0006874]; lipid localization [GO:0010876]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of interleukin-2 production [GO:0032743]; protein complex oligomerization [GO:0051259]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]" actin cytoskeleton [GO:0015629]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; T cell receptor binding [GO:0042608] APVPGTPDSLSSGSSR 1 4.5 0.10329 0.36488 9.78385 9.4503 9.57962 0 0 0 0 0 0 0 0 0 Q9UK05 GDF2_HUMAN Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9) GDF2 BMP9 Homo sapiens (Human) activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA replication [GO:0008156]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cartilage development [GO:0061036]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein serine/threonine kinase activator activity [GO:0043539] LEVTVESHR;SLNLSGVPSQDKTR 2 5.4 0.97085 -1.3375 0 12.396 0 0 0 0 0 0 0 0 0 0 Q9UK10 ZN225_HUMAN Zinc finger protein 225 ZNF225 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEECGKR;EFNQSSHLQIHQRIHTGEKPFK;EVMLENFR;FTQNSQLYTHR;VHSGETTFKCEECGK 5 11.9 0.97836 -1.9827 0 0 0 0 5.05176 9.96415 0 0 0 6.96659 0 0 Q9UK11 ZN223_HUMAN Zinc finger protein 223 ZNF223 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] DTFHFLREEKFWMMDIATQR 1 4.1 0.85004 -0.075624 11.6879 0 0 0 0 0 0 0 0 0 0 0 Q9UK12 ZN222_HUMAN Zinc finger protein 222 ZNF222 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] EEKFWVMGTTSQR;IHTGEKPFKCEICGKSFCLR;LYKSEKYGR;MIDSGEKKPGR 4 10.8 0.98014 -2.0395 0 0 0 0 10.7519 5.92835 0 0 0 0 10.358 0 Q9UK13 ZN221_HUMAN Zinc finger protein 221 ZNF221 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEECGKGFYTNSR;CEECGKR;SFCYSPALHIHQR 3 5.3 0.91833 -0.4361 8.69098 0 9.23184 0 0 0 0 0 0 8.07682 0 0 Q9UK17 KCND3_HUMAN A-type voltage-gated potassium channel KCND3 (Potassium voltage-gated channel subfamily D member 3) (Voltage-gated potassium channel subunit Kv4.3) KCND3 Homo sapiens (Human) action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; muscle contraction [GO:0006936]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; ventricular cardiac muscle cell membrane repolarization [GO:0099625] dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; Kv4.3-KChIP1 channel complex [GO:0071196]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008] IYHQNQRADK;QDELIVLNVSGRRFQTWR 2 4.3 0.97883 -1.9181 0 0 8.29939 0 0 0 9.048 0 0 0 0 0 Q9UK22 FBX2_HUMAN F-box only protein 2 FBXO2 FBX2 Homo sapiens (Human) "ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; negative regulation of cell population proliferation [GO:0008285]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein ubiquitination [GO:0031396]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; extrinsic component of postsynaptic membrane [GO:0098890]; glutamatergic synapse [GO:0098978]; SCF ubiquitin ligase complex [GO:0019005] amyloid-beta binding [GO:0001540]; carbohydrate binding [GO:0030246]; denatured protein binding [GO:0031249]; ubiquitin-protein transferase activity [GO:0004842] FVRFEHGGQDSVYWK;VLAALPAAELVQACR;VTNSSVWVEP 3 13.5 0.0024938 1.6949 0 0 0 0 0 0 0 0 0 8.29089 10.8482 0 Q9UK23 NAGPA_HUMAN N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; lysosome organization [GO:0007040]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299] Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020] N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity [GO:0003944] VAQNGGFFR 1 1.7 0.93393 -0.51515 0 0 0 0 0 0 0 0 0 0 0 10.6725 Q9UK28 TM59L_HUMAN Transmembrane protein 59-like (Brain-specific membrane-anchored protein) TMEM59L BSMAP C19orf4 Homo sapiens (Human) branching involved in ureteric bud morphogenesis [GO:0001658] Golgi membrane [GO:0000139]; membrane [GO:0016020] DPFAPQLGDTQNCQLRCR 1 5.3 0.92209 -0.44053 0 0 0 0 7.30879 0 0 0 0 0 0 0 Q9UK32 KS6A6_HUMAN Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) RPS6KA6 RSK4 Homo sapiens (Human) "central nervous system development [GO:0007417]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of embryonic development [GO:0045992]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mesoderm development [GO:2000381]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KRTSTGL;LHYAFQTEGK;VEIVNPYEVK;YGQHPNIITLK 4 5.1 0.98036 -1.5995 0 12.0682 0 0 0 0 0 0 0 0 0 0 Q9UK33 ZN580_HUMAN Zinc finger protein 580 (LDL-induced EC protein) ZNF580 Homo sapiens (Human) cellular response to hydrogen peroxide [GO:0070301]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte chemotaxis [GO:0002690]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GYSCPECAR 1 5.2 0.84739 -0.072693 0 0 0 0 0 0 0 5.44215 0 0 0 0 Q9UK39 NOCT_HUMAN Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) NOCT CCR4 CCRN4L NOC Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA stabilization [GO:0048255]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; P-body assembly [GO:0033962]; positive regulation of fat cell differentiation [GO:0045600]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; response to lipopolysaccharide [GO:0032496]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; NADP phosphatase activity [GO:0019178]; NADPH phosphatase activity [GO:0102757]; poly(A)-specific ribonuclease activity [GO:0004535] LYSALAK 1 1.6 0.91631 -0.33359 0 0 0 0 0 0 0 0 0 3.79732 0 0 Q9UK41 VPS28_HUMAN Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) VPS28 Homo sapiens (Human) macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] ELMETMHRMSHLPPDFEGR;FRLDCPLAMERIK 2 14.5 0.87256 -0.10889 7.17033 0 0 0 0 0 0 6.89336 0 0 0 0 Q9UK45 LSM7_HUMAN U6 snRNA-associated Sm-like protein LSm7 LSM7 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal tri-snRNP complex [GO:0097526]; U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] U6 snRNA binding [GO:0017070] QLGLVVCR 1 7.8 0.78511 0.02473 0 0 0 14.6053 0 0 16.8782 3.41752 4.47735 0 0 16.0861 Q9UK53 ING1_HUMAN Inhibitor of growth protein 1 ING1 Homo sapiens (Human) negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; protein import into nucleus [GO:0006606]; regulation of programmed cell death [GO:0043067] nucleus [GO:0005634]; Sin3-type complex [GO:0070822] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] ALIRSQELGDEKIQIVSQMVELVENR;ELDECYER 2 12.2 0.87187 -0.095318 0 4.67999 0 0 0 0 5.98046 4.40402 7.7387 0 0 0 Q9UK55 ZPI_HUMAN Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Serpin A10) SERPINA10 ZPI UNQ707/PRO1358 Homo sapiens (Human) blood coagulation [GO:0007596]; liver regeneration [GO:0097421] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] EEEEDEQEASEEK;IPKLFDEINPETKLILVDYILFK;LILVDYILFK;VPMMYGAGK 4 10.1 0.98128 -1.7032 0 0 0 0 9.22238 0 0 0 0 0 6.29849 10.1252 Q9UK61 TASOR_HUMAN Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) TASOR C3orf63 FAM208A KIAA1105 Homo sapiens (Human) "anterior/posterior axis specification, embryo [GO:0008595]; constitutive heterochromatin formation [GO:0140719]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of gene expression, epigenetic [GO:0045814]; protein localization to heterochromatin [GO:0097355]; transposable element silencing by heterochromatin formation [GO:0141005]" heterochromatin [GO:0000792]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] ALFQPLTPGSR;ELINLIQCR;FLYSAPR;GLHVGQSK;HEYELNSTPDK;IASNPLER;LGNTECHPEQFLER;LKELFEENRK;LLCYISLR;NFLTFLEELSTPEGKWQWK;QRSSDYQFPSSPFTDTLK 11 7.4 0.975 -3.2552 7.85661 7.96081 0 0 0 9.8352 0 9.72098 0 11.7671 10.0518 0 Q9UK76 JUPI1_HUMAN "Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed]" JPT1 ARM2 HN1 Homo sapiens (Human) cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] RNSSEASSGDFLDLK 1 9.7 0.54771 0.18377 0 0 0 0 0 0 0 0 0 0 7.20056 0 Q9UK80 UBP21_HUMAN Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) USP21 USP23 PP1490 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; transcription initiation-coupled chromatin remodeling [GO:0045815] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] VSLRDCFNLFTK 1 2.1 0.92327 -0.44761 0 0 0 0 0 8.01195 0 0 0 0 0 0 Q9UK85 DKKL1_HUMAN Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1) DKKL1 SGY1 UNQ735/PRO1429 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; canonical Wnt signaling pathway [GO:0060070]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of testosterone biosynthetic process [GO:2000225]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600] acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615] co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019] LQAIRDGLRK 1 4.1 0.76661 0.058744 0 0 0 6.7385 0 0 0 0 0 0 0 0 Q9UK96 FBX10_HUMAN F-box only protein 10 FBXO10 FBX10 PRMT11 Homo sapiens (Human) apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] ENQWGGVDIRR;SVFCTIL;VTAMATR 3 2.6 0.97795 -1.5284 0 0 0 0 0 10.3269 0 7.95501 9.45278 0 0 0 Q9UK97 FBX9_HUMAN F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) FBXO9 FBX9 VCIA1 Homo sapiens (Human) fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of TOR signaling [GO:0032006]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] LIWIHHSCHITYK 1 2.9 0.78679 0.017819 0 0 0 0 0 0 0 0 11.4946 0 0 0 Q9UK99 FBX3_HUMAN F-box only protein 3 FBXO3 FBX3 Homo sapiens (Human) protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to lipopolysaccharide [GO:0032496]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] ITNAKGDVEEVQGPGVVGEFPIISPGR 1 5.7 0.841 -0.045996 0 0 12.3708 0 0 0 0 0 0 0 0 0 Q9UKA1 FBXL5_HUMAN F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein) FBXL5 FBL4 FBL5 FLR1 Homo sapiens (Human) intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] "2 iron, 2 sulfur cluster binding [GO:0051537]; iron ion binding [GO:0005506]; ubiquitin-protein transferase activity [GO:0004842]" DLIYFGSEKSDQETGR;ITSTAWKNKDITMQSTK;SLYATFK;VIAQHCSQK 4 7.3 0.97757 -1.5002 0 0 8.34665 0 9.38955 3.9803 10.8915 10.3415 0 10.2624 0 0 Q9UKA2 FBXL4_HUMAN F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] TLDLWRCK 1 1.3 0.91422 -0.33804 0 0 8.76431 0 0 0 0 0 0 0 0 0 Q9UKA4 AKA11_HUMAN A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) AKAP11 AKAP220 KIAA0629 Homo sapiens (Human) cortical actin cytoskeleton organization [GO:0030866]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; renal water homeostasis [GO:0003091] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157] LTSSVLQMAFDELRR;QGSLASSKPASNPK;SDLKESAK;SLTDSCLFEK 4 2.5 0.98094 -2.0324 0 9.41395 0 0 0 0 0 8.92947 0 0 6.33684 0 Q9UKA8 RCAN3_HUMAN Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3) RCAN3 DSCR1L2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; calcium-mediated signaling [GO:0019722] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; RNA binding [GO:0003723]; troponin I binding [GO:0031013] EQSRHPAWWFMSVKVK 1 13.9 0.85046 -0.075146 0 0 0 0 0 0 0 0 0 0 6.17754 0 Q9UKB1 FBW1B_HUMAN F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS) FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696 Homo sapiens (Human) brain morphogenesis [GO:0048854]; establishment of mitotic spindle orientation [GO:0000132]; germ cell development [GO:0007281]; microtubule organizing center organization [GO:0031023]; negative regulation of DNA-templated transcription [GO:0045892]; nuclear migration [GO:0007097]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; retrograde axonal transport [GO:0008090]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; vesicle transport along microtubule [GO:0047496]; Wnt signaling pathway [GO:0016055] axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010]; protein dimerization activity [GO:0046983]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LIERMVRTDPLWK;VLEGHEELVR;VLEGHEELVRCIR 3 4.8 0.95897 -1.0391 0 0 0 0 0 0 10.1981 0 0 0 0 0 Q9UKB3 DJC12_HUMAN DnaJ homolog subfamily C member 12 (J domain-containing protein 1) DNAJC12 JDP1 Homo sapiens (Human) cytoplasm [GO:0005737] MENEECNEQR;MENEECNEQRERK 2 6.6 0.86965 -0.096547 0 0 0 0 0 4.64409 0 0 0 0 0 4.78654 Q9UKB5 AJAP1_HUMAN Adherens junction-associated protein 1 (Membrane protein shrew-1) AJAP1 MOT8 SHREW1 Homo sapiens (Human) cell adhesion [GO:0007155]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of wound healing [GO:0061045]; regulation of polarized epithelial cell differentiation [GO:0030860] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877] IPGGVSTTEPSTSPSNNGEVTQPPR 1 6.1 0.81123 0.0037449 0 0 0 0 0 0 0 0 0 0 0 7.90785 Q9UKD1 GMEB2_HUMAN Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) GMEB2 KIAA1269 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DAGLLDEVIQEFHQELVETMR;IDLSGAR 2 5.3 0.91741 -0.35761 0 0 0 15.4922 0 0 0 11.2656 9.24317 0 0 0 Q9UKD2 MRT4_HUMAN mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4) MRTO4 C1orf33 MRT4 Homo sapiens (Human) nuclear-transcribed mRNA catabolic process [GO:0000956]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] "cytoplasm [GO:0005737]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] QLGLPTALKR 1 4.2 0.36035 0.23258 12.5116 0 12.4611 9.44619 0 0 11.6221 11.6562 11.5781 10.1289 10.3142 11.151 Q9UKE5 TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) TNIK KIAA0551 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of dendrite morphogenesis [GO:0048814]; regulation of MAPK cascade [GO:0043408]; Wnt signaling pathway [GO:0016055] "apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; recycling endosome [GO:0055037]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AIDEDLTALAK;ALFLIPR;ALFLIPRNPAPRLK;KPLYHYKEGMSPSEKPAWAK;NRILHNDPEVEK;RRAEHEQEYIR;SLDEIDLSALR;VKPEESR 8 6.3 0.97915 -1.535 13.3346 0 0 0 9.74292 0 0 10.9595 7.22236 10.4887 0 0 Q9UKF2 ADA30_HUMAN Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-) ADAM30 UNQ2509/PRO5997 Homo sapiens (Human) male gonad development [GO:0008584]; proteolysis [GO:0006508] external side of plasma membrane [GO:0009897]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DCNYMGSVK;LSSDWAHLYLQR;SVQIFLSQCRLLLLLVPTMLLK;YLELILLFDQSRYR 4 7.2 0.95366 -0.78082 0 0 0 0 0 0 0 0 11.3201 7.43863 10.9526 9.72865 Q9UKF5 ADA29_HUMAN Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29) (Cancer/testis antigen 73) (CT73) ADAM29 Homo sapiens (Human) male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] CIMHEGNPPITK;GYGGSVDSGPPPK;IVEIVVVIDNYLYIRYER;QFSTMRSGFMQNEITCR;VGHCGIK 5 8.2 0.97231 -2.7895 0 9.45845 0 9.65003 9.7524 9.51481 11.6679 11.7935 11.3621 11.8225 11.4562 0 Q9UKG9 OCTC_HUMAN Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) CROT COT Homo sapiens (Human) carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] carnitine O-octanoyltransferase activity [GO:0008458] CHSEPDGPGIAALTSEERTR;HLLGLLLIAK;VLNDINQAKAQYLR 3 7.2 0.94481 -0.62467 0 0 8.7075 0 5.11049 0 0 0 0 0 9.33733 0 Q9UKI8 TLK1_HUMAN Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) TLK1 KIAA0137 Homo sapiens (Human) chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275] nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EGAMDELHSLDPRR;QQEWVNQQREDIERQR;SMQDRLRLGHFTTVR 3 5.7 0.93615 -0.53234 0 0 0 8.18824 6.91013 0 0 0 0 0 0 0 Q9UKJ0 PILRB_HUMAN Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT) PILRB FDFACT PP1551 Homo sapiens (Human) activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288] EDQSVYFCRVELDTRR;TVILGLLCLLLLWWR;TVILGLLCLLLLWWRRR 3 14.5 0.95218 -0.75566 6.99752 11.2249 0 9.16068 8.28286 8.63198 6.84273 0 0 6.33378 0 0 Q9UKJ1 PILRA_HUMAN Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha) PILRA Homo sapiens (Human) signal transduction [GO:0007165] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288] LSSTTTTTGLR;QDQSVYFCRVELDTR 2 8.6 0.95504 -0.83482 0 0 0 0 11.6098 0 0 0 0 11.6491 10.8633 0 Q9UKJ3 GPTC8_HUMAN G patch domain-containing protein 8 GPATCH8 GPATC8 KIAA0553 Homo sapiens (Human) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] AESGEKSK;ASEQMDGDNTTHPK;DEGGGGSSSQDHGGRK;DHLQGLDPGEPNKSK;EDEDPQDGGSLASTLSK;GTEKPKDIGSSSK;KDEGGGGSSSQDHGGR;LGVSFSFAK;RHKYSSSDDDYSLSCSQSR;SKEVGGEKIVR;SYSDDSYSDYSDR;VLEVEKEDTEELR 12 9.8 0.97515 -4.0508 11.1003 0 0 0 6.35385 9.43917 8.66327 0 0 12.5765 8.14883 9.35903 Q9UKJ5 CHIC2_HUMAN Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia) CHIC2 BTL Homo sapiens (Human) Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ALEEQLLK;SIEKLLEWENNR 2 12.1 0.95492 -0.94765 0 0 13.1362 0 0 0 0 0 0 0 0 0 Q9UKK3 PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) DNA damage response [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein modification process [GO:0036211]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spindle microtubule [GO:0005876] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779] DYEDGILHENETSHEMKK;KQTLKSLIIK;MWVEKHPEK 3 2.1 0.97378 -2.4205 0 0 5.46891 0 0 0 0 0 0 0 0 0 Q9UKK9 NUDT5_HUMAN ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) NUDT5 NUDIX5 HSPC115 Homo sapiens (Human) ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate metabolic process [GO:0006753]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; snoRNA binding [GO:0030515] ELEEETGYK;EQTADGVAVIPVLQR;MESQEPTESSQNGKQYIISEELISEGK;TTYMDPTGK 4 27.4 0.98034 -1.8691 0 0 0 0 0 0 0 0 0 9.99421 8.70217 0 Q9UKL0 RCOR1_HUMAN REST corepressor 1 (Protein CoREST) RCOR1 KIAA0071 RCOR Homo sapiens (Human) chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357] DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] EVPPTETVPQVK 1 2.5 0.80399 0.012737 0 0 0 0 0 0 0 0 0 0 6.88521 0 Q9UKL3 C8AP2_HUMAN CASP8-associated protein 2 (FLICE-associated huge protein) CASP8AP2 FLASH KIAA1315 RIP25 Homo sapiens (Human) apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; death receptor binding [GO:0005123]; peptidase activator activity involved in apoptotic process [GO:0016505]; SUMO polymer binding [GO:0032184]; transcription corepressor activity [GO:0003714] EILLECQKRGPSFK;EKLSKSEDPVHYK;ISKSVTTLQKNLCDIIESK;KDELKSEPGSNCDNSELPGTLHNSHK;KSEENYQDQNNSSINTVK;NEITFSHNSSKYHLEERR;NSQSEER;VMSTSSLEK 8 6.3 0.96715 -1.3021 0 0 0 0 0 0 11.5022 9.55855 11.082 8.39883 0 10.9355 Q9UKM7 MA1B1_HUMAN "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)" MAN1B1 UNQ747/PRO1477 Homo sapiens (Human) "ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; oligosaccharide metabolic process [GO:0009311]; protein alpha-1,2-demannosylation [GO:0036508]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082]" cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ADSYYEYLLK;KEFEEAR;RDVEVKPADRHNLLRPETVESLFYLYR 3 6.3 0.91646 -0.41529 0 0 0 0 0 0 6.71493 0 5.65435 0 9.48228 0 Q9UKM9 RALY_HUMAN RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) RALY HNRPCL2 P542 Homo sapiens (Human) "cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription by RNA polymerase II [GO:0000122]" catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] AAVLGENGR;ANPDGKK;LEQIAAEQK;LEQIAAEQKANPDGK;SSELQAIK;STAVTTSSAK;VFIGNLNTALVK;VTVPLVR 8 20.3 0 2.5222 11.9105 10.3367 0 8.85219 8.55628 8.18606 10.4153 0 9.99195 10.2107 0 0 Q9UKN1 MUC12_HUMAN Mucin-12 (MUC-12) (Mucin-11) (MUC-11) MUC12 MUC11 Homo sapiens (Human) regulation of cell growth [GO:0001558] Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] GTKSQMNCNLGTCQLQR;LSPARSTTSGLVGESTPSR 2 1.7 0.95566 -0.86851 0 0 0 8.71987 0 0 0 0 0 8.06727 0 0 Q9UKN7 MYO15_HUMAN Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) actin filament organization [GO:0007015]; endocytosis [GO:0006897]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; stereocilium [GO:0032420] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] ALSAFGAHR;EVMQQIK;LFMGFRDR;LILRYLAAMNQKR;MKALFAQNQLDTQKPLVTESVK;RRGPDFGWR;SLEPPEELTQTR;TLVDDFILELK;VGYSAGCVVR;VLYALLFSWLITRVNALVSPR;VTETMREK;YLAAMNQK 12 3.7 0.97858 -8.9069 0 0 0 0 9.8327 0 8.73173 0 0 8.51814 12.8242 12.6271 Q9UKN8 TF3C4_HUMAN General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) GTF3C4 Homo sapiens (Human) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; RNA polymerase III general transcription initiation factor activity [GO:0000995] ILPVNLKAVK;LSDVFGSVR;VSVSTAR 3 3.2 0.94477 -0.63 0 0 0 8.22386 0 0 5.69014 0 0 0 0 0 Q9UKP4 ATS7_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of chondrocyte differentiation [GO:0032331]; ossification involved in bone maturation [GO:0043931]; proteoglycan metabolic process [GO:0006029]; proteolysis involved in protein catabolic process [GO:0051603] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GVQRQNVYCLER;ITHHADNTLK;LSFGFCETLRLLGR;LSFGFCETLRLLGRCQLPTIR;PGGPSPR 5 3 0.97352 -2.4726 0 11.7912 0 0 6.69321 0 0 0 0 11.7769 0 0 Q9UKP6 UR2R_HUMAN Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R) UTS2R GPR14 Homo sapiens (Human) blood circulation [GO:0008015]; blood vessel diameter maintenance [GO:0097746]; neuropeptide signaling pathway [GO:0007218]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; urotensin II receptor activity [GO:0001604] KLLALGTWLLALLLTLPVMLAMRLVR;RPGARALR 2 8.7 0.88342 -0.17301 0 0 0 0 0 0 0 0 0 0 11.1767 0 Q9UKQ2 ADA28_HUMAN "Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)" ADAM28 ADAM23 MDCL Homo sapiens (Human) proteolysis [GO:0006508]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] immunoglobulin receptor binding [GO:0034987]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] DKIKITPNASFTLENFSK 1 2.3 0.96354 -1.1072 0 0 0 0 0 0 8.98028 0 0 0 0 0 Q9UKR8 TSN16_HUMAN Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) membrane [GO:0016020]; plasma membrane [GO:0005886] AEIHTPYSSLK 1 6.9 0.84787 -0.069378 0 0 0 0 0 0 0 0 0 10.9794 0 0 Q9UKS6 PACN3_HUMAN Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) PACSIN3 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium channel inhibitor activity [GO:0019855]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543] LCGDLVSCFQERAR;LSALHLEVREK 2 5.9 0.96325 -1.0839 10.6167 0 0 0 0 0 0 0 0 9.36477 9.51722 0 Q9UKS7 IKZF2_HUMAN Zinc finger protein Helios (Ikaros family zinc finger protein 2) IKZF2 HELIOS ZNFN1A2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] CPFCSYACR 1 1.7 0.84966 -0.073536 0 0 0 0 0 0 0 0 2.43162 0 0 0 Q9UKT4 FBX5_HUMAN F-box only protein 5 (Early mitotic inhibitor 1) FBXO5 EMI1 FBX5 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948] GAFQLYSK 1 1.8 0.93315 -0.50897 0 0 0 0 0 0 0 9.90937 0 0 11.1679 0 Q9UKT6 FXL21_HUMAN Putative F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B) FBXL21P FBL21 FBL3 FBXL21 FBXL3B FBXL3P Homo sapiens (Human) entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] IEDTPVDDPSLK;KRNSLSVENK;VGLNCPR 3 6.7 0.95131 -0.66984 12.4452 0 0 0 10.1243 0 0 0 0 0 0 8.46336 Q9UKT8 FBXW2_HUMAN F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) FBXW2 FBW2 FWD2 Homo sapiens (Human) protein modification process [GO:0036211]; proteolysis [GO:0006508] cytosol [GO:0005829] ubiquitin-protein transferase activity [GO:0004842] SICLQPR;VISACTEVWQTACK 2 4.6 0.94505 -0.65012 0 0 0 0 0 0 5.10136 0 0 0 0 0 Q9UKT9 IKZF3_HUMAN Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKZF3 ZNFN1A3 Homo sapiens (Human) B cell differentiation [GO:0030183]; mesoderm development [GO:0007498]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AEMSNGAPQELEK;DALTGHLRTHSVEKPYKCEFCGR;DEYSERDENVLK;DPFECNMCGYR;DPFECNMCGYRSHDR 5 12.4 0.97992 -1.5677 0 0 5.98039 0 0 0 0 4.91834 0 4.99408 0 8.72144 Q9UKT9 IKZF3_HUMAN Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKZF3 ZNFN1A3 Homo sapiens (Human) B cell differentiation [GO:0030183]; mesoderm development [GO:0007498]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AEMSNGAPQELEK;DPFECNMCGYR;DPFECNMCGYRSHDR;SHEMENVDSGEGPANEDEDIGASAEAR 4 16.8 0.89748 -0.25281 7.63198 5.33289 0 0 0 0 0 0 0 0 0 0 Q9UKU0 ACSL6_HUMAN Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) ACSL6 ACS2 FACL6 KIAA0837 LACS5 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; neuroblast proliferation [GO:0007405]; very long-chain fatty acid metabolic process [GO:0000038] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; long-chain fatty acid-CoA ligase activity [GO:0004467]; protein homodimerization activity [GO:0042803] AKRPELR;GEGEICVRGPNVFK;GPNVFKGYLKDPDR;LAQGEYVAPEK;VTEGDIR 5 7.6 0.97497 -4.1516 12.7038 0 0 10.8465 0 0 8.26007 0 10.7717 0 0 9.56524 Q9UKU6 TRHDE_HUMAN Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase) TRHDE UNQ2507/PRO5995 Homo sapiens (Human) cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; pyroglutamyl-peptidase activity [GO:0016920]; zinc ion binding [GO:0008270] ALYPLDK;LIEFYEDYFKVPYSLPK;NHHAGGDSWQPEAGGVASPGTTSAQPPSEEER 3 5.2 0.88304 -0.17422 0 0 0 0 0 0 5.33024 0 7.97877 0 7.81449 0 Q9UKU7 ACAD8_HUMAN "Isobutyryl-CoA dehydrogenase, mitochondrial (IBDH) (EC 1.3.8.5) (Activator-recruited cofactor 42 kDa component) (ARC42) (Acyl-CoA dehydrogenase family member 8) (ACAD-8)" ACAD8 ARC42 IBD Homo sapiens (Human) lipid metabolic process [GO:0006629]; valine catabolic process [GO:0006574] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; short-chain 2-methyl fatty acyl-CoA dehydrogenase activity [GO:0003853] AFISGAGESDIYVVMCRTGGPGPK;GTPGLSFGKK;IGSEGQGFLIAVR;SLTSCIDPSMGLNEEQK 4 15.4 0.97624 -1.4813 0 11.31 10.765 0 0 0 0 0 0 6.08226 0 0 Q9UKU9 ANGL2_HUMAN Angiopoietin-related protein 2 (Angiopoietin-like protein 2) ANGPTL2 ARP2 UNQ170/PRO196 Homo sapiens (Human) blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] GGSYSLK 1 1.4 0.91504 -0.33163 0 0 7.32903 0 0 0 0 0 0 0 0 0 Q9UKV0 HDAC9_HUMAN Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR Homo sapiens (Human) "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cholesterol homeostasis [GO:0042632]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of skeletal muscle fiber development [GO:0048742]; regulation of striated muscle cell differentiation [GO:0051153]; response to amphetamine [GO:0001975]" cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]" IIEIQSK;QYQQQIHMNKLLSKSIEQLK;YTLPGAQDAK 3 3.5 0.93597 -0.51945 0 8.18686 0 0 0 0 0 0 0 11.5675 0 0 Q9UKV3 ACINU_HUMAN Apoptotic chromatin condensation inducer in the nucleus (Acinus) ACIN1 ACINUS KIAA0670 Homo sapiens (Human) "apoptotic chromosome condensation [GO:0030263]; erythrocyte differentiation [GO:0030218]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of monocyte differentiation [GO:0045657]; RNA splicing [GO:0008380]" ASAP complex [GO:0061574]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP hydrolysis activity [GO:0016887]; enzyme binding [GO:0019899]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] EKAQEEPPAKLLDDLFR;LSQPESAEKHVTQR;TALHGVK 3 2.8 0.96573 -1.134 0 0 0 0 0 0 9.62542 10.9466 0 0 0 0 Q9UKV5 AMFR_HUMAN E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) AMFR RNF45 Homo sapiens (Human) endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450] FSKSADER;YLFHEVQR 2 2.5 0.98041 -1.723 11.8589 0 0 0 0 0 0 0 0 0 0 0 Q9UKV8 AGO2_HUMAN Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) AGO2 EIF2C2 Homo sapiens (Human) "miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of translational initiation [GO:0045947]; P-body assembly [GO:0033962]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of trophoblast cell migration [GO:1901165]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; regulation of synapse maturation [GO:0090128]; regulatory ncRNA-mediated gene silencing [GO:0031047]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; siRNA processing [GO:0030422]; siRNA-mediated gene silencing by mRNA destabilization [GO:0090625]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] "core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; endoribonuclease activity, cleaving siRNA-paired mRNA [GO:0070551]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; translation initiation factor activity [GO:0003743]" RPASHQTFPLQQESGQTVECTVAQYFKDR 1 3.4 0.87818 -0.13832 0 0 0 0 0 0 0 0 0 0 0 10.2967 Q9UKW4 VAV3_HUMAN Guanine nucleotide exchange factor VAV3 (VAV-3) VAV3 Homo sapiens (Human) angiogenesis [GO:0001525]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell adhesion [GO:0045785]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to xenobiotic stimulus [GO:0009410]; small GTPase-mediated signal transduction [GO:0007264]; vesicle fusion [GO:0006906] cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] EIIDLQQYK;EIIDLQQYKIANNPTTDKENK;ESGEYAISIKYNNEAK;LALDAMK;VLKYHLLLQELVKHTTDPTEK 5 7.7 0.95503 -0.86644 7.48357 0 0 0 5.17101 8.44737 0 0 13.1511 0 0 0 Q9UKW6 ELF5_HUMAN ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2) ELF5 ESE2 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" VVKSEALAKMWGQR 1 8.8 0.86576 -0.087462 0 0 0 0 0 0 0 0 0 7.376 0 0 Q9UKX2 MYH2_HUMAN "Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)" MYH2 MYHSA2 Homo sapiens (Human) muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] AEAHFALIHYAGVVDYNITGWLEK;ALQEAHQQTLDDLQAEEDK;ILRIQLELNQVKSEVDR;ILYADFKQR;ILYADFKQRYK;LAQESIMDIENEK;LASADIETYLLEKSRVVFQLK;LYDQHLGK;VQLLHTQNTSLINTKK 9 6.6 0.98127 -1.7637 0 0 0 0 8.66494 0 13.6521 10.3835 0 9.06598 0 0 Q9UKX2 MYH2_HUMAN "Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)" MYH2 MYHSA2 Homo sapiens (Human) muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] AEAHFALIHYAGVVDYNITGWLEK;EEQSNTNLAK;LASADIETYLLEKSRVVFQLK;LYDQHLGK 4 8.9 0.92948 -0.46997 0 0 0 0 0 0 0 0 9.03006 0 0 0 Q9UKX3 MYH13_HUMAN "Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)" MYH13 Homo sapiens (Human) cellular response to starvation [GO:0009267]; muscle contraction [GO:0006936] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] DEQQTQLIHDLNMQK;ILYADFKQR;LYDQHLGK;MEIDDMASNIEALSK;QRLQGEVEDLMR;RQMEEETKAK;VIQYFATIAVTGDKKK;VLAEWKQK 8 4.8 0.94141 -0.61468 0 9.4824 0 0 0 10.1389 0 11.3313 10.595 8.09318 0 0 Q9UKX5 ITA11_HUMAN Integrin alpha-11 ITGA11 MSTP018 Homo sapiens (Human) cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen-activated signaling pathway [GO:0038065]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517]; osteoblast differentiation [GO:0001649]; substrate-dependent cell migration [GO:0006929] external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha11-beta1 complex [GO:0034681]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] DNMRLGLSLATNPK;EPGLDPTPK;TVAPALQR 3 2.6 0.96571 -1.1478 7.39275 0 0 0 0 0 0 0 0 0 0 10.8549 Q9UKY1 ZHX1_HUMAN Zinc fingers and homeoboxes protein 1 ZHX1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]" ITGLTKGEIK;NQFPHDSEIIR;VEGGYECK 3 3.3 0.98023 -1.8153 0 0 0 0 0 0 0 0 8.51377 9.93062 9.83286 0 Q9UKY4 POMT2_HUMAN Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) POMT2 Homo sapiens (Human) basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872] DVAAEAVARSPK;QQQVTTYLHKDYNNLWIIKK 2 4.3 0.97462 -2.3908 0 0 0 0 0 0 0 0 0 0 11.2721 0 Q9UKY7 CDV3_HUMAN Protein CDV3 homolog CDV3 H41 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] DEDEWKELEQK;EEDDNEK 2 7 0.9356 -0.533 0 0 0 0 0 3.868 0 0 0 11.109 0 0 Q9UKZ1 CNO11_HUMAN CCR4-NOT transcription complex subunit 11 CNOT11 C2orf29 C40 Homo sapiens (Human) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634] LLKTLDTGETPSETKMSK 1 3.5 0.447 0.19202 0 0 0 0 0 0 0 0 0 0 11.2463 0 Q9UKZ4 TEN1_HUMAN Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)] TENM1 ODZ1 TNM1 Homo sapiens (Human) immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuropeptide signaling pathway [GO:0007218]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of transcription by RNA polymerase III [GO:0006359] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] GSDDTQHSPR;GTIVPELQVVQEEIPIPSSFVR;VELDTSNR 3 1.5 0.95573 -0.87194 0 0 0 0 0 9.64084 0 11.803 0 0 0 8.51755 Q9UKZ9 PCOC2_HUMAN Procollagen C-endopeptidase enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) (PCPE-2) (Procollagen C-proteinase enhancer 2) PCOLCE2 PCPE2 UNQ250/PRO287 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830] extracellular region [GO:0005576] collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504] ITVPEGK;RGLNYIIMGQVGEDGR 2 5.5 0.13498 0.35545 0 0 0 0 9.49219 0 9.14065 0 0 0 0 0 Q9UL01 DSE_HUMAN Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2) DSE SART2 Homo sapiens (Human) chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] chondroitin-glucuronate 5-epimerase activity [GO:0047757]; metal ion binding [GO:0046872] NTASFRK 1 0.7 0.64005 0.17307 0 9.36179 0 0 0 0 0 0 0 0 0 0 Q9UL03 INT6_HUMAN Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) INTS6 DBI1 DDX26 DDX26A Homo sapiens (Human) regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] actin cytoskeleton [GO:0015629]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transmembrane signaling receptor activity [GO:0004888] EIRKPGR;RANQINHINSN 2 2 0.96527 -1.1583 0 0 0 0 0 0 6.13592 0 0 0 0 0 Q9UL12 SARDH_HUMAN "Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)" SARDH DMGDHL1 Homo sapiens (Human) sarcosine catabolic process [GO:1901053] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] sarcosine dehydrogenase activity [GO:0008480] AVMAAGAK;ERSHESYAK;VAAAHPR 3 2.6 0.96451 -1.2316 0 7.80871 0 0 8.76168 0 0 0 5.84144 0 0 0 Q9UL15 BAG5_HUMAN BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5) BAG5 KIAA0873 Homo sapiens (Human) Golgi organization [GO:0007030]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein refolding [GO:0061084]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of inclusion body assembly [GO:0090083]; regulation of ubiquitin-protein transferase activity [GO:0051438] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] adenyl-nucleotide exchange factor activity [GO:0000774]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] MDMGNQHPSISRLQEIQKEVK;TDKNYIRLEELLTK 2 7.8 0.95443 -0.88611 0 0 10.1831 4.88054 0 0 0 0 0 0 0 0 Q9UL16 CFA45_HUMAN Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1) CFAP45 CCDC19 NESG1 Homo sapiens (Human) cerebrospinal fluid circulation [GO:0090660]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] AMP binding [GO:0016208] KANILPATSVN;MVRELIVPTEDPSGESLIISPEEFERIK;WASHVLTREELEARDQAFK 3 12.4 0.98206 -1.5863 0 0 0 0 0 0 0 0 0 0 11.5945 0 Q9UL17 TBX21_HUMAN T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM) TBX21 TBET TBLYM Homo sapiens (Human) cell fate specification [GO:0001708]; lymphocyte migration [GO:0072676]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of T cell differentiation [GO:0045580]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]; T-helper 1 cell lineage commitment [GO:0002296] chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" LYVHPDSPNTGAHWMR;RMFPFLSFTVAGLEPTSHYR 2 6.7 0.39816 0.21061 9.86487 0 0 9.03785 0 0 9.93598 0 0 0 7.02547 0 Q9UL18 AGO1_HUMAN Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) AGO1 EIF2C1 Homo sapiens (Human) miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; regulation of mRNA stability [GO:0043488]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727] LVAFRARYHLVDK;NTYSGLQLIIVILPGKTPVYAEVK 2 4.3 0.83573 -0.034544 0 0 0 0 0 0 7.73268 0 0 0 0 0 Q9UL25 RAB21_HUMAN Ras-related protein Rab-21 RAB21 KIAA0118 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; intracellular protein transport [GO:0006886]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157] axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] AAAGGGGGGAAAAGR;HITTLQASFLTKKLNIGGK;MIETAQVDER 3 19.6 0 33.608 0 2.2103 0 0 0 0 7.22843 9.48969 7.72989 9.68182 0 0 Q9UL26 RB22A_HUMAN Ras-related protein Rab-22A (Rab-22) RAB22A RAB22 Homo sapiens (Human) endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; regulation of vesicle size [GO:0097494] actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; ruffle [GO:0001726] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVMERDAK 1 4.1 0.97736 -1.5225 0 0 0 0 0 0 0 0 8.98171 0 0 0 Q9UL36 ZN236_HUMAN Zinc finger protein 236 ZNF236 Homo sapiens (Human) cellular response to glucose stimulus [GO:0071333]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ACKKEFETSSELK;CPHCELR;EGRAHQCLECDR;ISELRDKQAELQDEPK;SLGSLNTHISK 5 3.2 0.97678 -2.2802 11.5061 7.77373 0 0 0 0 8.66327 0 11.0593 6.8134 0 0 Q9UL40 ZN346_HUMAN Zinc finger protein 346 (Just another zinc finger protein) ZNF346 JAZ Homo sapiens (Human) cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ARRLWEAVSGAQPVGR;GYPCKTCK;LDSDQKSSR 3 11.2 0.97429 -3.6306 0 0 0 0 0 0 0 11.4297 0 0 0 9.87804 Q9UL41 PNMA3_HUMAN Paraneoplastic antigen Ma3 PNMA3 MA3 Homo sapiens (Human) positive regulation of apoptotic process [GO:0043065] nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AGSRGSR 1 1.5 0.71331 0.15097 0 0 13.2871 5.0568 0 0 0 0 0 0 0 0 Q9UL42 PNMA2_HUMAN Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2) PNMA2 KIAA0883 MA2 Homo sapiens (Human) positive regulation of apoptotic process [GO:0043065] nucleolus [GO:0005730] IMSVDEQK;TPNQDTEFLER 2 5.2 0.95642 -0.99432 0 0 0 0 0 0 0 0 0 0 0 10.6301 Q9UL45 BL1S6_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) BLOC1S6 PA PLDN Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; adenosine metabolic process [GO:0046085]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; ATP metabolic process [GO:0046034]; blood coagulation [GO:0007596]; bradykinin biosynthetic process [GO:0002936]; cellular response to epidermal growth factor stimulus [GO:0071364]; cilium assembly [GO:0060271]; circadian sleep/wake cycle [GO:0042745]; dentate gyrus development [GO:0021542]; endosome to melanosome transport [GO:0035646]; endothelium development [GO:0003158]; gene expression [GO:0010467]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; homeostasis of number of cells [GO:0048872]; hypothalamus development [GO:0021854]; intracellular nitric oxide homeostasis [GO:0033484]; intracellular transport [GO:0046907]; kidney development [GO:0001822]; lipid homeostasis [GO:0055088]; lung alveolus development [GO:0048286]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; membrane fusion [GO:0061025]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neuron projection development [GO:0031175]; phospholipid metabolic process [GO:0006644]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of pigment cell differentiation [GO:0050942]; protein targeting [GO:0006605]; protein transmembrane transport [GO:0071806]; respiratory system process [GO:0003016]; response to acetylcholine [GO:1905144]; response to activity [GO:0014823]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299]; synaptic vesicle docking [GO:0016081]; vasodilation [GO:0042311] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cell-cell contact zone [GO:0044291]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; microvesicle [GO:1990742]; presynapse [GO:0098793]; ruffle [GO:0001726]; stress fiber [GO:0001725]; transport vesicle [GO:0030133] actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905] SKQALQELTTKLYC 1 17.5 0.8647 -0.088044 0 0 0 0 7.68285 0 0 0 0 0 0 0 Q9UL46 PSME2_HUMAN Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) PSME2 Homo sapiens (Human) regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802] DEAAYGELR 1 3.8 0.90707 -0.30355 0 0 0 0 0 0 0 0 0 0 10.4086 0 Q9UL49 TCFL5_HUMAN Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1) TCFL5 CHA E2BP1 Homo sapiens (Human) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VGEAALCK;VGEAALCKQALK;VLPEQVWIK;VLPEQVWIKVGEAALCK 4 4.2 0.97913 -1.9025 0 0 0 0 0 0 0 0 8.88041 0 7.67709 10.0803 Q9UL52 TM11E_HUMAN Transmembrane protease serine 11E (EC 3.4.21.-) (Serine protease DESC1) (Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain] TMPRSS11E DESC1 TMPRSS11E2 UNQ742/PRO1461 Homo sapiens (Human) cognition [GO:0050890]; proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LESMVKNAFYK;VDPHSVK 2 4.3 0.95442 -0.80054 0 0 0 0 0 0 0 0 0 8.22689 0 10.6232 Q9UL54 TAOK2_HUMAN Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; stress-activated MAPK cascade [GO:0051403] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] ELDNLQYRK;ERPPTVIMDLIQR;NPRTTQHPLALLARVWVLCK;QRQYFELQCR;TASLVSR 5 4.8 0.75075 0.078829 13.7449 13.6895 6.71108 0 0 0 0 4.35734 0 6.95222 8.76646 0 Q9UL54 TAOK2_HUMAN Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; stress-activated MAPK cascade [GO:0051403] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] ELDNLQYRK;ERPPTVIMDLIQR;NSPQPLR;QRQYFELQCR;TASLVSR 5 4.4 0.68162 0.16448 0 6.01643 0 0 0 0 0 0 10.0097 0 0 0 Q9UL58 ZN215_HUMAN Zinc finger protein 215 (BWSCR2-associated zinc finger protein 2) (BAZ-2) (Zinc finger protein with KRAB and SCAN domains 11) ZNF215 BAZ2 ZKSCAN11 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DSALQMGSIKEKMK;DVVVEFSKEEWGQLDSAVK;LTESGHPSSDAWKGENWLYRNQK;MQPLSKLMAISKPR;SHTTMNSYECYQCGK 5 16.4 0.96779 -1.3193 0 0 0 0 10.1306 0 0 7.31805 0 5.8055 0 6.17836 Q9UL59 ZN214_HUMAN Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) ZNF214 BAZ1 Homo sapiens (Human) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] RNQPGENLCQCSICKACFSQR;SQEEKFR;YLEYENFSYWQGWWNAGAQMYENQNYGETVQGTDSK 3 10.6 0.97913 -1.9024 0 0 11.414 0 0 0 0 9.94015 0 0 0 0 Q9UL62 TRPC5_HUMAN Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5) TRPC5 TRP5 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630] calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" RYVAAMIR;SALLIAIENENLEIMELLLNHSVYVGDALLYAIRK;SFSTSSTELSQRDDNNDGSGGARAK;SNLGLFIKKPFIK 4 8.3 0.97963 -1.8875 10.6442 10.6501 10.5384 8.44564 8.89078 0 0 0 0 8.23434 10.5572 0 Q9UL63 MKLN1_HUMAN Muskelin MKLN1 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell-matrix adhesion [GO:0007160]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; regulation of cell shape [GO:0008360]; regulation of receptor internalization [GO:0002090]; signal transduction [GO:0007165]; vesicle-mediated transport in synapse [GO:0099003] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; nucleoplasm [GO:0005654]; postsynaptic endosome membrane [GO:0098895]; postsynaptic specialization membrane of symmetric synapse [GO:0099164]; ruffle [GO:0001726]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] LDDFWSLK;SLKSDFYR;YEKTHVCNLK 3 3.5 0.97508 -3.1555 0 11.8438 0 0 0 0 0 0 0 10.6106 12.5355 0 Q9UL68 MYT1L_HUMAN Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) MYT1L KIAA1106 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; zinc ion binding [GO:0008270]" ALLENIK;DLITLSGCPLADK;EEDEGEEYSEDNDEPGDEDEEDEEGDR;EVDTEEK;SLSGCPIAAAEK 5 5.6 0.97516 -1.4571 0 11.012 0 0 0 9.51023 0 0 11.5581 4.07005 0 0 Q9ULA0 DNPEP_HUMAN Aspartyl aminopeptidase (EC 3.4.11.21) DNPEP ASPEP DAP Homo sapiens (Human) peptide metabolic process [GO:0006518]; proteolysis [GO:0006508] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DLTLAGR;QVAMNGK 2 2.9 0.95445 -0.9588 0 0 0 0 0 0 0 0 0 0 0 9.71663 Q9ULB1 NRX1A_HUMAN Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) "adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]" cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982] acetylcholine receptor binding [GO:0033130]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023] GYLHYVFDLGNGANLIK;LGRVVDEWLLDK;NNGMCRDGWNR 3 2.6 0.91743 -0.42109 0 0 0 0 0 0 0 8.05175 4.01355 0 0 0 Q9ULB5 CADH7_HUMAN Cadherin-7 CDH7 CDH7L1 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EEQAYYTLRAQALDR;LDREEQAYYTLRAQALDR;SYQYNVPESLPVASVVARIK;YSIDRNTDLER 4 6.2 0.97532 -1.4402 0 0 0 0 9.73949 0 0 0 4.59054 8.80723 0 0 Q9ULC0 MUCEN_HUMAN Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14) EMCN EMCN2 MUC14 Homo sapiens (Human) hematopoietic stem cell homeostasis [GO:0061484] extracellular region [GO:0005576]; plasma membrane [GO:0005886] SYSSIILPVVIALIVITLSVFVLVGLYR 1 10.7 0.71422 0.14212 0 0 0 0 0 0 0 0 0 0 4.82156 0 Q9ULC3 RAB23_HUMAN Ras-related protein Rab-23 RAB23 HSPC137 Homo sapiens (Human) autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; GTP metabolic process [GO:0046039]; intracellular protein transport [GO:0006886]; negative regulation of protein import into nucleus [GO:0042308] autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EDLNVNEVFKYLAEKYLQK;IDLLDDSCIK 2 12.2 0.90996 -0.28059 0 0 0 7.97785 0 0 0 0 0 13.3547 0 0 Q9ULC5 ACSL5_HUMAN Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 5) (LACS 5) ACSL5 ACS5 FACL5 UNQ633/PRO1250 Homo sapiens (Human) long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; regulation of extrinsic apoptotic signaling pathway [GO:2001236] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434] IENIYNR;KPNQPYRWLSYK;NNDLTSCCFSDAK;RGELSKYFR;TLKPTLFPAVPR;VGFFQGDIRLLADDMK 6 10.1 0.97455 -3.1227 0 0 0 6.89445 0 7.02625 0 0 0 0 0 12.2387 Q9ULC6 PADI1_HUMAN Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I) PADI1 PAD1 PDI1 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; histone H1R54 arginine deiminase activity [GO:0140810]; histone H2AR3 arginine deiminase activity [GO:0140811]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; histone H4R3 arginine deiminase activity [GO:0140809]; protein-arginine deiminase activity [GO:0004668] FLEDMSYLTLK;ILIGSSFPKSGGRQMAR 2 4.2 0.91626 -0.34457 0 0 0 0 0 0 0 0 0 0 0 7.93216 Q9ULC8 ZDHC8_HUMAN Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) ZDHHC8 KIAA1292 ZDHHCL1 ZNF378 Homo sapiens (Human) high-density lipoprotein particle assembly [GO:0034380]; locomotory behavior [GO:0007626]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein palmitoylation [GO:0018345]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]; postsynapse [GO:0098794] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] LGPATGPPGPSASPTRHTLVKK;LSDNGLK;SKSKGSLDR;SLSLKASSRR;YGSRDDLVAGPGFGGAR 5 8.5 0.97952 -1.9995 0 10.0355 0 0 0 0 12.2396 8.70912 0 7.84931 0 9.28392 Q9ULD0 OGDHL_HUMAN "2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)" OGDHL KIAA1290 Homo sapiens (Human) 2-oxoglutarate metabolic process [GO:0006103]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] LSGQDVER;LSGQDVERGTFSHR;NITLSLVANPSHLEAVDPVVQGK;QILLPFRKPLIIFTPKSLLR;YHLGMYHER 5 6.5 0.84703 -0.063073 5.73571 8.94629 0 0 0 0 10.4927 0 0 7.89197 8.49701 5.17923 Q9ULD2 MTUS1_HUMAN Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 Homo sapiens (Human) regulation of macrophage chemotaxis [GO:0010758] centrosome [GO:0005813]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] microtubule binding [GO:0008017] DSICQCPALVGTEKPK;GEKENGTSMEKQELK;LSMENEELLWK;TPRSDLNADKK 4 4.2 0.97609 -1.4656 0 0 0 0 0 5.85075 0 10.6305 10.7782 0 0 0 Q9ULD4 BRPF3_HUMAN Bromodomain and PHD finger-containing protein 3 BRPF3 KIAA1286 Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of DNA replication [GO:0045740]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; extracellular region [GO:0005576]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleus [GO:0005634] metal ion binding [GO:0046872] LSLMAPDTPAGTPLSGVGR;SRQNAEGRR;VEEDELLEK 3 3.1 0.97852 -1.9087 0 0 0 0 0 0 0 9.49053 0 0 0 0 Q9ULD5 ZN777_HUMAN Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; protein heterooligomerization [GO:0051291] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GASSQQQRNR;HHLLEHRR;LHISLVIHQRVHAGK;LTNHCRVHSR 4 5.2 0.95379 -0.89399 0 0 0 10.0672 9.34127 4.95954 10.1869 0 0 10.4405 9.89257 0 Q9ULD6 INTU_HUMAN Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) INTU KIAA1284 PDZD6 PDZK6 Homo sapiens (Human) cell division [GO:0051301]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; hair follicle morphogenesis [GO:0031069]; intraciliary transport [GO:0042073]; keratinocyte differentiation [GO:0030216]; limb development [GO:0060173]; motile cilium assembly [GO:0044458]; negative regulation of cell division [GO:0051782]; negative regulation of keratinocyte proliferation [GO:0010839]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to organelle [GO:0033365]; regulation of cilium assembly [GO:1902017]; regulation of ossification [GO:0030278]; regulation of smoothened signaling pathway [GO:0008589]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord dorsal/ventral patterning [GO:0021513]; tongue morphogenesis [GO:0043587]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] phosphatidylinositol binding [GO:0035091] ELEIYNTVK;LLPKRCNK 2 1.8 0.97885 -1.9651 0 0 0 10.2569 0 0 0 0 0 0 0 0 Q9ULD8 KCNH3_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Potassium voltage-gated channel subfamily H member 3) (Voltage-gated potassium channel subunit Kv12.2) KCNH3 KIAA1282 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity [GO:0005249] ADIAMHLHKEVLQLPLFEAASRGCLR;ALEGLRLPPMPWNVPPDLSPR;ETGGGRR;GEVALFLVSHK;LETPYYLVGR;LGGRGRPGR;LLRLLPRLDR;TRDLRDYIR 8 9.5 0.97201 -2.6996 0 0 10.1577 0 0 9.73276 0 0 0 8.79445 12.0782 0 Q9ULD9 ZN608_HUMAN Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) ZNF608 KIAA1281 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872] AGKNSGK;KATNCKTDK;KEEEEEESHRR;SEELDREK;TSKDANK 5 2.8 0.97523 -4.0903 0 7.4851 0 0 0 0 11.1492 0 10.7577 0 12.245 0 Q9ULE0 WWC3_HUMAN Protein WWC3 WWC3 KIAA1280 Homo sapiens (Human) cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] GVETLQEIDR;GVETLQEIDRK;ISACLSDYSLASDSGVFEPLTKR;REQERMLK 4 3.5 0.66744 0.16861 0 0 0 0 0 0 5.4363 0 0 0 0 0 Q9ULE0 WWC3_HUMAN Protein WWC3 WWC3 KIAA1280 Homo sapiens (Human) cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] GVETLQEIDR;GVETLQEIDRK;QCQEVGEEGTPHLR;REQERMLK 4 4.7 0.98008 -2.0402 11.8537 0 10.2966 0 10.7243 0 0 0 0 0 0 0 Q9ULE3 DEN2A_HUMAN DENN domain-containing protein 2A DENND2A KIAA1277 Homo sapiens (Human) "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" actin cytoskeleton [GO:0015629]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] EVDPSWGRGREPR;ISEWEGK;VTDENSESDSDTEEK 3 3.5 0.9362 -0.52682 4.7241 0 0 4.17473 0 0 12.0883 0 0 0 0 0 Q9ULE4 F184B_HUMAN Protein FAM184B FAM184B KIAA1276 Homo sapiens (Human) AEVEQHQQEAQK;AQLEASHQRALRMLEK;EVEAQLEEVR;LEGDLEHRGR;SVRSSVEAERK;TELVSENK;VENQQLSK;VLLKEGSDPQPPLGSLLK 8 8.8 0.97532 -4.2553 9.16536 12.5122 0 0 0 8.81647 10.1378 13.2797 0 0 12.1134 0 Q9ULE6 PALD_HUMAN Paladin PALD1 KIAA1274 PALD Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829] protein tyrosine phosphatase activity [GO:0004725] AKSIIPNK;GEFQVVMKVVQLLPDGHRVK;LPVTLSSAGPVAPRDLIAR;YVCLILFNAYLHLEK 4 7.2 0.97963 -1.9947 0 0 11.8121 0 9.13904 0 0 0 7.40625 0 0 0 Q9ULF5 S39AA_HUMAN Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) SLC39A10 KIAA1265 ZIP10 Homo sapiens (Human) epithelial to mesenchymal transition [GO:0001837]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] VHNPGHSHVHLPER;YGENGRLSFFGLEK 2 3.4 0.95557 -0.98131 0 0 0 0 0 0 0 0 0 0 8.21694 0 Q9ULG1 INO80_HUMAN Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) INO80 INO80A INOC1 KIAA1259 Homo sapiens (Human) cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] cytosol [GO:0005829]; Ino80 complex [GO:0031011]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] "actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; histone binding [GO:0042393]" AAALRAANK;GSGSTAK;HHHQTKVFAK;ILLQFQCR;ILLQFQCRNR;KYEKVEK;LDEEMREAK;NCKETLPR;NLFLTNSRKLAHQCMK;VLPYWGNPHDR 10 5.6 0.97478 -3.7182 11.0594 5.8896 11.2651 0 8.83766 8.92787 0 8.46123 12.0602 8.73796 0 0 Q9ULG3 CFA92_HUMAN Uncharacterized protein CFAP92 (Putative cilia and flagella associated protein 92) CFAP92 KIAA1257 Homo sapiens (Human) MRRFYHIEYFLLPDDEEPK;VRYYRLK 2 6.4 0.97613 -2.3393 0 0 0 11.8727 8.30656 0 0 0 0 0 0 0 Q9ULG6 CCPG1_HUMAN Cell cycle progression protein 1 (Cell cycle progression restoration protein 8) CCPG1 CCP8 CPR8 KIAA1254 Homo sapiens (Human) positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944] membrane [GO:0016020] ETFDAMK;QRMVNIENSR 2 2.1 0.96792 -1.3036 0 0 0 0 0 9.49273 0 0 0 0 0 0 Q9ULH0 KDIS_HUMAN Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976] cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; protein-containing complex [GO:0032991] PDZ domain binding [GO:0030165]; protein kinase regulator activity [GO:0019887] GGYTQSVK;NPKDGRLLYRPNK;SPEHSAEPIRTFIK;VPKSPEHSAEPIRTFIK;YADIDIR 5 2.5 0.97482 -3.4586 0 0 0 0 10.0909 8.55754 0 11.5977 0 0 0 9.62919 Q9ULH0 KDIS_HUMAN Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976] cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; protein-containing complex [GO:0032991] PDZ domain binding [GO:0030165]; protein kinase regulator activity [GO:0019887] LPQYCTTIK;SPEHSAEPIRTFIK;VPKSPEHSAEPIRTFIK 3 4.8 0.84713 -0.064899 0 0 0 0 0 0 0 0 9.52824 0 0 0 Q9ULH1 ASAP1_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 KIAA1249 PAG2 Homo sapiens (Human) cilium assembly [GO:0060271]; Golgi to plasma membrane protein transport [GO:0043001]; negative regulation of dendritic spine development [GO:0061000]; positive regulation of cilium assembly [GO:0045724]; positive regulation of membrane tubulation [GO:1903527]; protein localization to cilium [GO:0061512]; regulation of postsynapse organization [GO:0099175] cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; podosome [GO:0002102]; trans-Golgi network membrane [GO:0032588] "cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" GPTGPPSTLPLSTQTSSGSSTLSKK;KSFDLISHNR;TALQKVKK 3 3.8 0.97577 -1.4634 0 0 0 0 0 0 12.1516 10.6099 0 0 0 0 Q9ULH4 LRFN2_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (Synaptic adhesion-like molecule 1) LRFN2 KIAA1246 SALM1 Homo sapiens (Human) modulation of chemical synaptic transmission [GO:0050804]; regulation of postsynapse organization [GO:0099175] cell surface [GO:0009986]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] SLHLDSNR;SLSVNGMLLPFEESDLVGAR 2 3.5 0.91733 -0.36067 0 11.0687 0 8.93917 8.42135 0 0 0 0 0 0 0 Q9ULH7 MRTFB_HUMAN Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) MRTFB KIAA1243 MKL2 Homo sapiens (Human) muscle organ development [GO:0007517]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of modification of postsynaptic structure [GO:0099159]; smooth muscle cell differentiation [GO:0051145] glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713] CSEKSVSSIIPGINS;LQLRLQQRR 2 6.3 0.97406 -3.0429 9.07559 0 0 0 0 0 0 0 0 0 9.57456 0 Q9ULI0 ATD2B_HUMAN ATPase family AAA domain-containing protein 2B ATAD2B KIAA1240 Homo sapiens (Human) nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; transcription initiation-coupled chromatin remodeling [GO:0045815] nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577] HRKDYDK;LDSIDPALR;RRSQWGK 3 1.6 0.96526 -1.2479 0 0 0 0 0 0 8.23926 0 0 0 0 0 Q9ULI1 NWD2_HUMAN NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) synapse [GO:0045202] DSPITVSDSTESNEATPSK;ISVDCLWR;IVLSTLPNKHGILQK;IVLSTLPNKHGILQKLR;NVTLLVWANRHLQLIAQK;RAAFSGNLTALPSHLVPAGR 6 4.7 0.97819 -1.9326 0 8.79588 0 0 10.1764 0 13.1616 13.5059 0 14.3144 8.18978 0 Q9ULI2 RIMKB_HUMAN Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B) RIMKLB FAM80B KIAA1238 Homo sapiens (Human) glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; citrate-L-glutamate ligase activity [GO:0072591]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590] HEAPYLFQKYVK 1 3.1 0.2994 0.25251 0 0 0 5.71705 0 9.74804 0 4.66215 0 0 0 0 Q9ULI4 KI26A_HUMAN Kinesin-like protein KIF26A KIF26A KIAA1236 Homo sapiens (Human) cerebral cortex development [GO:0021987]; enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975] cytosol [GO:0005829]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017] ATSSLKAR;LVSGPGTTLR;VGCARLGQSPPGR 3 1.6 0.98041 -2.0363 0 0 8.45582 11.5179 0 0 0 0 0 0 0 0 Q9ULJ1 ODF2L_HUMAN Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) (ODF2-like protein) ODF2L BCAP KIAA1229 Homo sapiens (Human) cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] ELERVCDSLTAAER;LEQMDAENKELEK;TISEKEDLPR;TISEKEDLPRCTSESHLSCLK 4 7.5 0.97496 -2.3744 0 0 0 0 0 9.98342 0 0 0 10.1243 6.60761 0 Q9ULJ3 ZBT21_HUMAN Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) ZBTB21 KIAA1227 ZNF295 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; POZ domain binding [GO:0031208]" LCHRTFK;LCHRTFKTAFSLWSHEQTHN;LIDIVREREIK;VFVEDDENSSQKRSVIVCQSR 4 4.9 0.93344 -0.50801 11.835 0 0 9.82037 0 0 8.98365 8.7065 0 0 0 0 Q9ULJ6 ZMIZ1_HUMAN Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17) ZMIZ1 KIAA1224 RAI17 ZIMP10 Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; artery morphogenesis [GO:0048844]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; SMAD binding [GO:0046332]; SUMO ligase activity [GO:0061665]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] MPQQTYPGPRPQSLPIQNIK;VAAQQGFDLDLGYR 2 3.2 0.92759 -0.45871 7.7284 6.42801 0 4.50475 0 0 7.05376 7.50803 0 8.21694 0 0 Q9ULJ7 ANR50_HUMAN Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) endocytic recycling [GO:0032456]; protein transport [GO:0015031] endosome [GO:0005768] DIPGTLNGLYLWLCQR;SGSAGKK;SGTAAPPK 3 2.2 0.23259 0.29544 0 0 0 11.1997 12.0545 11.025 6.46154 0 9.94473 0 6.39631 5.92179 Q9ULJ8 NEB1_HUMAN Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) PPP1R9A KIAA1222 Homo sapiens (Human) actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; modulation of chemical synaptic transmission [GO:0050804]; neuron projection development [GO:0031175] actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015] FDTMYDGPSYSKFTETR;FSSAPIKVFNTYSNEDYDR;LDSKALKTR;RQRPSRTR 4 4.8 0.97264 -2.7366 0 0 0 0 6.37041 0 8.68001 0 0 9.31297 0 0 Q9ULK0 GRID1_HUMAN "Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)" GRID1 KIAA1220 Homo sapiens (Human) "glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic plasticity [GO:0031914]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; social behavior [GO:0035176]; synaptic signaling via neuropeptide [GO:0099538]; synaptic transmission, glutamatergic [GO:0035249]" extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; trans-synaptic protein complex [GO:0098820] G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; GABA receptor activity [GO:0016917]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ADLAISAITITPER;GLQSFLDQASR;QVEMSYGTVR 3 3.5 0.25195 0.27703 0 0 0 0 0 0 0 0 0 0 10.7887 6.93416 Q9ULK2 AT7L1_HUMAN Ataxin-7-like protein 1 (Ataxin-7-like protein 4) ATXN7L1 ATXN7L4 KIAA1218 Homo sapiens (Human) LSSDEGEMDGADESEK;QQEGRAMATLDR 2 3.3 0.81244 -0.013749 0 9.59107 0 3.35938 0 0 0 0 0 0 0 0 Q9ULK4 MED23_HUMAN Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2 Homo sapiens (Human) positive regulation of gene expression [GO:0010628]; positive regulation of T cell extravasation [GO:2000409]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription coactivator activity [GO:0003713] AQNDNSKLQIPIPHSLRLHHEFLQQSLR;GLLPYDK;LDPATLR;MLLETDHINQIGYRVLERIGAR;TEVIEEAFPGMFMDTPEDEK 5 6.1 0.95225 -0.73947 0 7.68601 0 9.2241 0 10.7581 4.40776 10.1187 0 0 0 0 Q9ULK5 VANG2_HUMAN Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) VANGL2 KIAA1215 STB1 Homo sapiens (Human) "apical protein localization [GO:0045176]; cell migration involved in kidney development [GO:0035787]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; heart looping [GO:0001947]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] LLILLLGSWALFFRRPK 1 3.3 0.92079 -0.44013 0 0 0 0 4.33907 0 0 0 0 0 0 0 Q9ULK6 RN150_HUMAN RING finger protein 150 RNF150 KIAA1214 Homo sapiens (Human) ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GNCTYRDK;NITVTMYITIGTRNLQKYR 2 6.8 0.97284 -2.6077 0 0 0 0 0 0 0 11.4297 11.3802 10.7304 0 0 Q9ULL0 K1210_HUMAN Acrosomal protein KIAA1210 KIAA1210 Homo sapiens (Human) acrosomal vesicle [GO:0001669] AHISVKELKTK;GFLPCTPRFPTTWCR;LLCQPLMNPK;VISVEPLLPR 4 2.7 0.97569 -3.3352 0 8.85991 0 2.20226 0 0 0 10.1654 0 0 7.1335 11.2081 Q9ULL1 PKHG1_HUMAN Pleckstrin homology domain-containing family G member 1 PLEKHG1 KIAA1209 Homo sapiens (Human) regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] CESHQDLLPDIADSHQQGTEK;ELQNSPK;EPLSFSVFHYKNPK;EPLSFSVFHYKNPKLQHTVQAK;LNDYLWR 5 4.1 0.96783 -1.3032 10.8575 0 0 0 0 0 9.71399 6.92967 0 11.2866 0 0 Q9ULL4 PLXB3_HUMAN Plexin-B3 PLXNB3 KIAA1206 PLXN6 Homo sapiens (Human) cell chemotaxis [GO:0060326]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of GTPase activity [GO:0034260]; negative regulation of lamellipodium assembly [GO:0010593]; positive chemotaxis [GO:0050918]; positive regulation of axonogenesis [GO:0050772]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neuron projection development [GO:0010976]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cell surface [GO:0009986]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] cell-cell adhesion mediator activity [GO:0098632]; protein domain specific binding [GO:0019904]; Rho GDP-dissociation inhibitor binding [GO:0051022]; semaphorin receptor activity [GO:0017154] LPGSFPQLR 1 0.5 0.90971 -0.31522 0 0 0 0 0 0 10.4505 0 0 0 0 0 Q9ULL5 PRR12_HUMAN Proline-rich protein 12 PRR12 KIAA1205 Homo sapiens (Human) neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] AGPSGATAGASGR;ASLVYGSSR;LEPLKPLKIKLSVPK 3 1.8 0.96538 -1.1595 0 0 0 3.14099 0 0 0 0 0 0 0 11.4732 Q9ULL8 SHRM4_HUMAN Protein Shroom4 (Second homolog of apical protein) SHROOM4 KIAA1202 SHAP Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; brain development [GO:0007420]; cognition [GO:0050890]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; myosin II binding [GO:0045159] EKLSLEPVLPARNPNR;KSEETSVYEEGSSLASMPHPLRSR;SIQNRRK 3 3.1 0.95611 -0.83866 0 0 7.12019 0 0 0 11.4146 0 0 9.45555 0 0 Q9ULM0 PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) PLEKHH1 KIAA1200 Homo sapiens (Human) cytoskeleton [GO:0005856] EGGPGSSLTLPK;GKDELISQLEAQLEKQK;LEMENQHLK;NVTVPVYTALKGR 4 3.7 0.97958 -1.9993 0 8.37938 0 5.92163 0 10.3612 10.373 0 0 0 10.0865 0 Q9ULM2 ZN490_HUMAN Zinc finger protein 490 ZNF490 KIAA1198 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATFKNLACIGEK;ECGRAFFSHSSLR;NIYRDVMRATFK;QCGKAFSYSKSLHVHER 4 9.5 0.9757 -3.4158 0 0 0 12.5774 0 12.1491 0 0 7.39498 0 13.2127 0 Q9ULM3 YETS2_HUMAN YEATS domain-containing protein 2 YEATS2 KIAA1197 Homo sapiens (Human) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; histone reader activity [GO:0140566]; modification-dependent protein binding [GO:0140030]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714] GKLLLIPQGAILR;HTPFYALPSSLERTPTK;TPTKMTTSQK 3 2.5 0.97674 -2.2053 0 0 0 0 3.54696 0 0 9.71622 11.2115 0 0 0 Q9ULM6 CNOT6_HUMAN CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) CNOT6 CCR4 CCR4a KIAA1194 Homo sapiens (Human) "miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of translation [GO:0006417]" CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532] MPKEKYEPPDPR;NGTTNGRITHGFK 2 4.5 0.953 -0.76871 0 0 0 8.74836 8.93723 0 7.92416 0 0 0 0 0 Q9ULN7 PNM8B_HUMAN Paraneoplastic antigen-like protein 8B (PNMA-like protein 2) PNMA8B KIAA1183 PNMAL2 Homo sapiens (Human) EFLALVTVTDK;VLRQMRR 2 2.8 0.97875 -2.1085 0 0 0 0 0 0 0 0 13.3667 11.8339 0 0 Q9ULN7 PNM8B_HUMAN Paraneoplastic antigen-like protein 8B (PNMA-like protein 2) PNMA8B KIAA1183 PNMAL2 Homo sapiens (Human) ELVRQWAPCNSEGGPCPTCPWEGIGGFGCDLTVQTR;VLRQMRR 2 15.4 0.81264 0.0015957 0 0 4.40252 0 0 0 0 0 0 0 0 0 Q9ULP9 TBC24_HUMAN TBC1 domain family member 24 TBC1D24 KIAA1171 Homo sapiens (Human) axon development [GO:0061564]; cellular response to oxidative stress [GO:0034599]; dendrite development [GO:0016358]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron projection development [GO:0031175]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron migration [GO:2001224]; synaptic vesicle endocytosis [GO:0048488] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195] GTPase activator activity [GO:0005096] DIAKTVSPEK;DIWSWVPER;MDSPGYNCFVDKDK;VALAILK 4 7.2 0.97312 -2.5242 0 0 0 0 0 0 0 4.30415 0 0 0 12.7562 Q9ULQ0 STRP2_HUMAN Striatin-interacting protein 2 (Protein FAM40B) STRIP2 FAM40B KIAA1170 Homo sapiens (Human) cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829]; FAR/SIN/STRIPAK complex [GO:0090443] EIIVKSISTLLLLLLKHFK;LEVVSRER;MNDDWAYGNGESSQSS;NLFSCINLLRLLNK 4 7.5 0.95227 -0.68334 0 0 0 0 0 0 8.61996 0 0 6.21457 0 0 Q9ULQ1 TPC1_HUMAN Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) TPCN1 KIAA1169 TPC1 Homo sapiens (Human) endocytosis involved in viral entry into host cell [GO:0075509]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of autophagy [GO:0010508] early endosome membrane [GO:0031901]; endolysosome [GO:0036019]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; monoatomic ion channel complex [GO:0034702]; recycling endosome membrane [GO:0055038] "identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; voltage-gated channel activity [GO:0022832]; voltage-gated sodium channel activity [GO:0005248]" GGNFFSK 1 0.9 0.68595 0.1632 0 0 0 0 0 0 0 0 0 10.2816 0 0 Q9ULR0 ISY1_HUMAN Pre-mRNA-splicing factor ISY1 homolog ISY1 KIAA1160 Homo sapiens (Human) "generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006] RNA binding [GO:0003723] YASETLQAQSEEARR 1 4.5 0.57948 0.18005 0 0 0 0 0 0 0 0 0 8.23764 0 0 Q9ULR3 PPM1H_HUMAN Protein phosphatase 1H (EC 3.1.3.16) PPM1H ARHCL1 KIAA1157 URCC2 Homo sapiens (Human) signal transduction [GO:0007165] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; identical protein binding [GO:0042802]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AGAVTSTPNR;GVLKDRGWR 2 3.7 0.97907 -1.9922 0 0 0 0 0 0 0 0 11.0771 0 0 0 Q9ULR5 PAI2B_HUMAN Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B) PAIP2B KIAA1155 Homo sapiens (Human) negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947] cytoplasm [GO:0005737] mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371] EFIPGEK 1 5.7 0.93806 -0.57392 0 0 0 0 9.53374 0 0 0 0 0 0 0 Q9ULS5 TMCC3_HUMAN Transmembrane and coiled-coil domain protein 3 TMCC3 KIAA1145 Homo sapiens (Human) endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802] SLKDAHVKSR;TYSYPGRHHR 2 4.2 0.95514 -0.8821 0 0 0 7.62264 8.95262 7.42114 0 0 0 0 0 0 Q9ULT0 TTC7A_HUMAN Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) TTC7A KIAA1140 TTC7 Homo sapiens (Human) hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GPEEALVTCR;LPNSIASRFR;SLAQKVLRDAVER 3 3.8 0.93354 -0.51228 0 0 11.789 0 0 0 0 7.76799 0 0 7.60874 0 Q9ULT8 HECD1_HUMAN E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) aorta development [GO:0035904]; heart valve development [GO:0003170]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; ventricular septum development [GO:0003281] nuclear speck [GO:0016607] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GGDIFLDQLAR;GVVVTLR;LALTLKVTGLGTTR;LDSSGER;LVDLLLVLLFEGRK;LVDLLLVLLFEGRKALPK;NIATQLESSWELHTNR;QWYDFDR;STTGAPSTTADSK 9 3.6 0.97197 -2.7202 0 12.5035 2.18145 0 9.83742 9.52587 0 0 8.56026 0 7.68222 10.431 Q9ULU4 ZMYD8_HUMAN MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein localization to chromatin [GO:0071168]; regulation of postsynaptic density protein 95 clustering [GO:1902897] chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] DNA-binding transcription factor binding [GO:0140297]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] ADPGAVK;FSSLQKSFNLAEEEIK;MYGCTEAFLADAK 3 3 0.95164 -0.68574 0 0 0 0 0 0 0 0 12.6682 9.50341 10.4398 0 Q9ULU8 CAPS1_HUMAN Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) CADPS CAPS CAPS1 KIAA1121 Homo sapiens (Human) dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal dense core vesicle membrane [GO:0099012]; presynapse [GO:0098793] lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] DSDEEDEEDD;LCSMEMGQEFAK 2 1.6 0.80754 0.0076388 2.90939 0 0 0 0 0 0 0 4.39115 5.13599 0 0 Q9ULV0 MYO5B_HUMAN Unconventional myosin-Vb MYO5B KIAA1119 Homo sapiens (Human) actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267] GHLARRLAEHLR;LEQEEYMK;LKGATLTLQRYCR;LLGVEHSQMEHWLCHR;VVQLQRK;YCRGHLARR 6 3 0.92869 -0.47127 0 7.94292 0 9.0305 0 0 0 0 0 6.68426 10.2528 0 Q9ULV1 FZD4_HUMAN Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) FZD4 Homo sapiens (Human) "angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cell population proliferation [GO:0008283]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; extracellular matrix-cell signaling [GO:0035426]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; Norrin signaling pathway [GO:0110135]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection arborization [GO:0150012]; progesterone secretion [GO:0042701]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; sensory perception of sound [GO:0007605]; substrate adhesion-dependent cell spreading [GO:0034446]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" cell surface [GO:0009986]; cell-cell junction [GO:0005911]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] GAGPSVPGAPGGVGLSLGLLLQLLLLLGPAR;GFGDEEER;GNGWVKPGKGSETVV;INIPIGPCGGMCLSVKRR;RRCEPVLK;TLHTWQK 6 15.8 0.95702 -1.0218 0 0 11.9147 12.0396 0 0 0 7.66988 11.2905 6.31334 7.23601 6.04107 Q9ULV3 CIZ1_HUMAN Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) CIZ1 LSFR1 NP94 ZNF356 Homo sapiens (Human) maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; random inactivation of X chromosome [GO:0060816] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclin binding [GO:0030332]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EPPGQLQVKAQPQAR;YFKTPRK 2 2.4 0.81326 -0.007712 0 0 0 0 7.91833 0 6.66107 6.32052 6.35468 0 0 0 Q9ULV4 COR1C_HUMAN Coronin-1C (Coronin-3) (hCRNN4) CORO1C CRN2 CRNN4 Homo sapiens (Human) actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; corpus callosum development [GO:0022038]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; establishment of protein localization [GO:0045184]; membrane fission [GO:0090148]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neural crest cell migration [GO:0001755]; phagocytosis [GO:0006909]; positive regulation of lamellipodium morphogenesis [GO:2000394]; regulation of epithelial cell migration [GO:0010632]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein phosphorylation [GO:0001932]; regulation of ruffle assembly [GO:1900027]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal transduction [GO:0007165]; ventricular system development [GO:0021591] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; endosome membrane [GO:0010008]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; sarcomere [GO:0030017]; synapse [GO:0045202] actin filament binding [GO:0051015]; small GTPase binding [GO:0031267] GCSIACQGSLTSAR;LEQQMAK;NADPILISLK;QLALWNPK 4 7.4 0.88876 -0.20126 0 9.54946 0 0 3.13042 8.40045 0 0 0 8.88426 8.56579 0 Q9ULV5 HSF4_HUMAN Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4) HSF4 Homo sapiens (Human) lens fiber cell differentiation [GO:0070306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FAKEVLPQYFK;LSPSSDGRREK;WRPEDLGR 3 6.1 0.97858 -2.0913 0 0 0 9.87846 0 0 0 0 9.51718 0 8.88249 0 Q9ULV8 CBLC_HUMAN E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C) CBLC CBL3 RNF57 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; response to glial cell derived neurotrophic factor [GO:1990790]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] membrane raft [GO:0045121]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LSVSPPSLR 1 1.9 0.93035 -0.48874 0 0 11.3557 0 0 0 0 0 0 0 0 0 Q9ULW0 TPX2_HUMAN Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) TPX2 C20orf1 C20orf2 DIL2 HCA519 Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of mitotic spindle organization [GO:0060236] axon hillock [GO:0043203]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922] importin-alpha family protein binding [GO:0061676]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] AQQLEEARLQEEEQKK;AQTWKHQLEEELR;SLRLSAQKDLEQK;TVEICPFSFDSR;TVEICPFSFDSRDK 5 7.5 0.97328 -2.4838 0 0 6.68173 0 5.98614 0 12.3229 0 6.207 0 0 0 Q9ULW2 FZD10_HUMAN Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) FZD10 Homo sapiens (Human) canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of JNK cascade [GO:0046330]; regulation of actin cytoskeleton organization [GO:0032956] cell surface [GO:0009986]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] TLQSWQQVCSRR 1 2.1 0.83687 -0.03214 0 0 0 12.3265 0 0 0 0 0 0 0 0 Q9ULW3 ABT1_HUMAN Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) ABT1 Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; regulation of transcription by RNA polymerase II [GO:0006357]; small-subunit processome assembly [GO:0034462]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]" nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] YLHRFTWSHLSEHLAFER 1 6.6 0.82568 -0.020587 0 0 0 8.63107 0 0 0 0 0 0 0 0 Q9ULW6 NP1L2_HUMAN "Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked)" NAP1L2 BPX Homo sapiens (Human) neuron differentiation [GO:0030182]; nucleosome assembly [GO:0006334]; positive regulation of neuron differentiation [GO:0045666]; regulation of stem cell division [GO:2000035] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393] DSFFNFFSPHGITSNGR 1 3.7 0.78503 0.024765 0 0 0 0 0 0 0 0 0 0 8.27193 0 Q9ULW8 PADI3_HUMAN Protein-arginine deiminase type-3 (EC 3.5.3.15) (Peptidylarginine deiminase III) (Protein-arginine deiminase type III) PADI3 PAD3 PDI3 Homo sapiens (Human) cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; histone H1R54 arginine deiminase activity [GO:0140810]; histone H2AR3 arginine deiminase activity [GO:0140811]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; histone H4R3 arginine deiminase activity [GO:0140809]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668] LVLHTSSYDAK 1 1.7 0.91523 -0.37366 0 0 0 0 0 10.6561 0 0 0 0 0 0 Q9ULX3 NOB1_HUMAN RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) NOB1 ART4 NOB1P PSMD8BP1 MSTP158 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; rRNA processing [GO:0006364]; visual perception [GO:0007601] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521] EARSYILRCHGCFK;EVVTEIRDKATR;KVSVTVSDDGTLHMHFSR;LAVLPYELR;LVTEFSKK;TGDYPSLSATDIQVLALTYQLEAEFVGVSHLK;TNVFAPDYIAGVSPFVENDISSR 7 28.2 0.97503 -1.4436 0 0 0 11.1957 0 0 12.3203 0 0 0 0 8.25597 Q9ULX5 RN112_HUMAN RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179) RNF112 BFP ZNF179 Homo sapiens (Human) embryonic brain development [GO:1990403]; endoplasmic reticulum organization [GO:0007029]; G1 to G0 transition involved in cell differentiation [GO:0070315]; neuron differentiation [GO:0030182]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of neuron differentiation [GO:0045666]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; regulation of cell cycle [GO:0051726]; response to hydroperoxide [GO:0033194] cell body [GO:0044297]; cytoplasm [GO:0005737]; endosome [GO:0005768]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AFMDSYTMR;LPGCEPPCCPECRK;SRCQGYWNEGR;VLPDTMR;VLPDTMRNLLSTQKDAILAR 5 8.6 0.92871 -0.46359 0 0 0 0 7.76792 0 10.2086 3.15643 3.91322 0 4.88333 0 Q9ULX6 AKP8L_HUMAN A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) AKAP8L NAKAP NAKAP95 HRIHFB2018 Homo sapiens (Human) cell cycle G2/M phase transition [GO:0044839]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; nuclear membrane disassembly [GO:0051081]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mRNA export from nucleus [GO:0010793]; RNA splicing [GO:0008380] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ribonucleoprotein complex [GO:1990904] DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; lamin binding [GO:0005521]; metal ion binding [GO:0046872]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723] IQFVCSLCK;LPKQTADFLQEYVTNKTK 2 4.2 0.88115 -0.14858 8.03243 0 0 0 0 6.83365 0 0 0 0 0 0 Q9ULX7 CAH14_HUMAN Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 Homo sapiens (Human) one-carbon metabolic process [GO:0006730] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] RSQISMEQLEK 1 3.3 0.64171 0.17272 0 0 0 0 0 0 0 0 0 0 7.14995 0 Q9ULZ3 ASC_HUMAN Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) PYCARD ASC CARD5 TMS1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; macropinocytosis [GO:0044351]; myeloid dendritic cell activation [GO:0001773]; myeloid dendritic cell activation involved in immune response [GO:0002277]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell migration [GO:2000406]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269]; regulation of autophagy [GO:0010506]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of protein stability [GO:0031647]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] AIM2 inflammasome complex [GO:0097169]; azurophil granule lumen [GO:0035578]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; IkappaB kinase complex [GO:0008385]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; NLRP6 inflammasome complex [GO:0140738]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] BMP receptor binding [GO:0070700]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; interleukin-6 receptor binding [GO:0005138]; myosin I binding [GO:0017024]; pattern recognition receptor activity [GO:0038187]; protease binding [GO:0002020]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; Pyrin domain binding [GO:0032090]; transmembrane transporter binding [GO:0044325]; tropomyosin binding [GO:0005523] AEPTNPSKMR;LFSFTPAWNWTCK 2 11.8 0.88313 -0.17128 10.8167 0 0 0 0 0 0 10.9313 0 0 0 0 Q9ULZ9 MMP17_HUMAN Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) MMP17 MT4MMP Homo sapiens (Human) collagen catabolic process [GO:0030574]; drinking behavior [GO:0042756]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LPLPLLLLLALGTR 1 2.3 0.8025 0.014244 0 0 0 0 4.74551 0 0 0 0 0 0 0 Q9UM00 TMCO1_HUMAN Calcium load-activated calcium channel (CLAC channel) (GEL complex subunit TMCO1) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3) TMCO1 TMCC4 PNAS-10 PNAS-136 UNQ151/PRO177 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; ossification [GO:0001503] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]; multi-pass translocon complex [GO:0160064] calcium channel activity [GO:0005262]; ribosome binding [GO:0043022] ALSPWRVR;LKNNNRDLSMVR 2 8.4 0.97258 -2.735 0 9.8627 10.4138 0 0 0 0 0 0 0 0 0 Q9UM01 YLAT1_HUMAN Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) SLC7A7 Homo sapiens (Human) amino acid transmembrane transport [GO:0003333]; basic amino acid transmembrane transport [GO:1990822]; L-arginine transmembrane transport [GO:1903826]; L-leucine transport [GO:0015820]; regulation of arginine metabolic process [GO:0000821] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459] LFFVGSR;VLALIAVIVAGIVR 2 4.1 0.80229 0.014243 0 0 2.97684 0 0 0 0 0 0 0 0 0 Q9UM11 FZR1_HUMAN Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) FZR1 CDH1 FYR FZR KIAA1242 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; DNA repair [GO:0006281]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LQPSTPEK;LTGHSYR;QIVIQNENTMPRVTEMR;SPRKPTRK;TPPLQSER;VQDPQTEDRR 6 11.7 0.97421 -2.4352 0 12.4763 0 0 0 0 0 0 9.06622 0 0 0 Q9UM13 APC10_HUMAN Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) ANAPC10 APC10 Homo sapiens (Human) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] EIGSQAVWSLSSCKPGFGVDQLR;TLCIYADYKSDESYTPSK 2 22.2 0.71326 0.14479 0 9.90854 0 0 0 0 9.65964 0 0 0 0 0 Q9UM21 MGT4A_HUMAN "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]" MGAT4A Homo sapiens (Human) glyoxylate metabolic process [GO:0046487]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; peroxisome [GO:0005777] "acetylglucosaminyltransferase activity [GO:0008375]; alanine-glyoxylate transaminase activity [GO:0008453]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]" IQKLTDKDYMKPLLLK;LEDGYFR 2 4.3 0.8763 -0.12398 0 7.70784 0 0 0 0 0 0 0 0 0 8.07001 Q9UM22 EPDR1_HUMAN Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) cell-matrix adhesion [GO:0007160]; myofibroblast contraction [GO:1990764] extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] calcium ion binding [GO:0005509]; ganglioside GM1 binding [GO:1905573]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] ALLSYDGLNQR 1 12.2 0.64885 0.17089 0 0 0 0 0 0 0 0 0 0 0 11.6113 Q9UM47 NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 Homo sapiens (Human) artery morphogenesis [GO:0048844]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; glomerular capillary formation [GO:0072104]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron fate commitment [GO:0048663]; Notch signaling pathway [GO:0007219]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] DVAQERLHQDIVR;IGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR;LDFPYPLRDVR;YLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINR 4 4.3 0.98058 -1.6131 10.853 7.51523 0 0 0 0 0 0 0 7.67793 0 10.6119 Q9UM54 MYO6_HUMAN Unconventional myosin-VI (Unconventional myosin-6) MYO6 KIAA0389 Homo sapiens (Human) "actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; regulation of secretion [GO:0051046]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]" actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; autophagosome [GO:0005776]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; unconventional myosin complex [GO:0016461] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; minus-end directed microfilament motor activity [GO:0060001] GAEILPRQFEEIWER;IDGLVKVGTLK;IGLDDEEKLDLFR;IPFIRPADQYKDPQSK;QILQNRK;RVNHWLTCSRWK;SLGTRPPHVFAIADKAFR 7 7.1 0.98101 -2.0309 9.16189 12.9007 9.75353 0 8.96116 0 0 0 8.16747 8.01452 0 0 Q9UM63 PLAL1_HUMAN Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC) PLAGL1 LOT1 ZAC Homo sapiens (Human) apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DHLKNHLQTHDPNK 1 3 0.92142 -0.43979 0 0 0 0 0 0 0 9.75424 0 0 0 0 Q9UM73 ALK_HUMAN ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK Homo sapiens (Human) adult behavior [GO:0030534]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; energy homeostasis [GO:0097009]; hippocampus development [GO:0021766]; negative regulation of lipid catabolic process [GO:0050995]; neuron development [GO:0048666]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of dendrite development [GO:1900006]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of neuron differentiation [GO:0045664]; response to environmental enrichment [GO:0090648]; response to stress [GO:0006950]; signal transduction [GO:0007165]; swimming behavior [GO:0036269] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AGRPEAR;KNITLIR 2 0.9 0.94539 -0.64336 7.37156 0 0 0 0 0 0 0 0 0 0 0 Q9UM82 SPAT2_HUMAN Spermatogenesis-associated protein 2 SPATA2 KIAA0757 PD1 Homo sapiens (Human) necroptotic process [GO:0070266]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin-specific protease binding [GO:1990381] KYVQFHESK 1 1.7 0.73192 0.11522 0 0 0 0 0 0 0 9.40303 0 0 0 0 Q9UMF0 ICAM5_HUMAN Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin) ICAM5 TLCN TLN Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]; regulation of synapse assembly [GO:0051963] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] integrin binding [GO:0005178] ALSGTYR;GGLETSLRRNGTQR;VPGAGPRASLTLTLLRGAQELIR 3 4.8 0.97968 -1.8411 0 0 0 0 11.3433 11.5506 0 0 0 0 9.87811 9.13271 Q9UMN6 KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7 Homo sapiens (Human) methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893] histone methyltransferase complex [GO:0035097]; MLL1/2 complex [GO:0044665]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] GIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSR;GRGSKHLLECER;IDQQQQQK;IEARKMER;LDDEEEEKKEEEEK;LFPIGYQCSR;MGQLSLGLESGQGQGQHEESWQDVPQRR;REKFYDGK;RVGSGQGGSPCWKK;VRMKTPTVR 10 5.5 0.97842 -7.5136 0 11.4648 8.66924 8.79666 0 10.9497 0 0 10.6929 10.0933 0 0 Q9UMQ3 BARX2_HUMAN Homeobox protein BarH-like 2 BARX2 Homo sapiens (Human) cartilage condensation [GO:0001502]; myotube differentiation [GO:0014902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LDLAQSLGLTQLQVKTWYQNRR 1 7.9 0.56198 0.18276 6.08666 0 0 0 0 0 0 0 0 0 0 0 Q9UMQ6 CAN11_HUMAN Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11) CAPN11 Homo sapiens (Human) proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233] LVFVHSTERSEFWSALLEK 1 2.6 0.91896 -0.43804 0 0 0 7.91421 0 0 0 0 0 0 0 0 Q9UMR3 TBX20_HUMAN T-box transcription factor TBX20 (T-box protein 20) TBX20 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; lateral mesoderm formation [GO:0048370]; mesenchymal cell development [GO:0014031]; motor neuron migration [GO:0097475]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; vasculogenesis [GO:0001570]; visceral motor neuron differentiation [GO:0021524] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" IDSNPFAK 1 1.8 0.91377 -0.39033 0 0 0 0 0 0 0 0 0 8.81845 0 0 Q9UMR5 PPT2_HUMAN Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14) PPT2 Homo sapiens (Human) fatty-acyl-CoA biosynthetic process [GO:0046949] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] palmitoyl hydrolase activity [GO:0098599]; palmitoyl-(protein) hydrolase activity [GO:0008474]; thiolester hydrolase activity [GO:0016790] LGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHR 1 10.6 0.83676 -0.033673 0 0 0 0 0 0 0 0 3.63773 0 0 0 Q9UMS4 PRP19_HUMAN Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) PRPF19 NMP200 PRP19 SNEV Homo sapiens (Human) "DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] FIASTGMDR;TVPEELVKPEELSK 2 4.6 0.95536 -0.82672 0 0 0 0 0 9.62185 0 0 0 9.64861 10.2077 0 Q9UMS5 PHTF1_HUMAN Protein PHTF1 PHTF1 PHTF Homo sapiens (Human) cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum membrane [GO:0005789] AKFSDGEK 1 1 0.91294 -0.33804 0 0 0 0 0 9.51142 0 0 0 0 0 0 Q9UMS6 SYNP2_HUMAN Synaptopodin-2 (Genethonin-2) (Myopodin) SYNPO2 Homo sapiens (Human) positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] 14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371] EADEEEEGDK;EETGPSYQRAPQMPDSQRGR;GAQLFAK;IVHINSIPTNEK;LNRGDKMEMLPDTTGK;SLSLPGR 6 5.7 0.97936 -1.5425 0 0 0 0 9.18093 0 11.9671 9.43375 0 0 7.1236 10.2512 Q9UMW8 UBP18_HUMAN Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18) USP18 ISG43 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]; regulation of protein stability [GO:0031647]; response to bacterium [GO:0009617]; response to stilbenoid [GO:0035634] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]; molecular adaptor activity [GO:0060090] ELSSKSK;LWNLIKDQITDVHLVER;SVPFQMLLLLEKMQDSR 3 11 0.9812 -1.7884 0 0 11.6901 0 0 7.54419 0 0 0 9.92192 10.0501 0 Q9UMX5 NENF_HUMAN Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein) NENF CIR2 SPUF Homo sapiens (Human) MAPK cascade [GO:0000165]; negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739] growth factor activity [GO:0008083]; metal ion binding [GO:0046872] RLRPLAALALVLALAPGLPTAR 1 12.8 0.33371 0.24136 0 0 0 0 0 0 8.3726 0 7.02879 0 0 0 Q9UMX9 S45A2_HUMAN Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2) SLC45A2 AIM1 MATP Homo sapiens (Human) developmental pigmentation [GO:0048066]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process from tyrosine [GO:0006583]; sucrose transport [GO:0015770]; visual perception [GO:0007601] melanosome membrane [GO:0033162]; membrane [GO:0016020] D-glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506] VKNGYVNPELAMQGAK 1 3 0.91675 -0.42559 0 10.333 0 0 0 0 0 0 0 0 0 0 Q9UMY4 SNX12_HUMAN Sorting nexin-12 SNX12 Homo sapiens (Human) endocytic recycling [GO:0032456]; late endosome to Golgi transport [GO:0034499]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; retromer complex [GO:0030904] enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266] IVVPPLPGKALKR 1 8 0.77135 0.055027 0 3.749 5.74187 0 0 0 0 0 0 0 0 0 Q9UMZ2 SYNRG_HUMAN Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) endocytosis [GO:0006897]; intracellular protein transport [GO:0006886] AP-1 adaptor complex [GO:0030121]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] CLGSALNVIKK;FEQQQKLLEEER;SLSLGDK;SRKEEKPAEEHPK 4 3.3 0.95496 -0.94502 0 0 0 0 0 9.65234 0 0 0 11.9681 6.3468 0 Q9UMZ3 PTPRQ_HUMAN Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.67) (EC 3.1.3.86) (EC 3.1.3.95) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) PTPRQ Homo sapiens (Human) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of fat cell differentiation [GO:0045598] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; receptor complex [GO:0043235]; stereocilium base [GO:0120044] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" EWESEECVEYQK;LTRPISK;SAPISILTEEDAPDSPPQDFSVK;VGSAGILLSWNTPPNPNGRIISYIVKYK 4 3 0.89681 -0.23598 0 12.0836 0 5.96807 0 0 0 8.72434 0 0 8.07521 0 Q9UN19 DAPP1_HUMAN Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) DAPP1 BAM32 HSPC066 Homo sapiens (Human) protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]" ILRWKLSQIR;VEEPSIYESVR 2 7.5 0.88596 -0.1824 0 0 0 0 0 9.09373 9.63378 0 0 0 0 0 Q9UN30 SCML1_HUMAN Sex comb on midleg-like protein 1 SCML1 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] IQRFHAR;LGTAVKLCYYIDR 2 6.1 0.98099 -1.7465 0 0 0 0 0 5.89918 8.82668 0 0 10.5738 0 0 Q9UN37 VPS4A_HUMAN Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) VPS4A VPS4 Homo sapiens (Human) actomyosin contractile ring contraction [GO:0000916]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cytoskeleton-dependent cytokinesis [GO:0061640]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; ESCRT complex disassembly [GO:1904896]; ESCRT III complex disassembly [GO:1904903]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic nuclear membrane reassembly [GO:0007084]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of cytokinesis [GO:0032466]; nuclear envelope organization [GO:0006998]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein disaggregase activity [GO:0140545]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; protein-containing complex binding [GO:0044877] AKCVQYLDR;RIYIPLPEEAARAQMFR 2 5.9 0.9746 -2.3854 0 0 0 0 0 0 0 0 0 0 9.40327 0 Q9UN42 AT1B4_HUMAN "Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m)" ATP1B4 Homo sapiens (Human) potassium ion transport [GO:0006813]; regulation of DNA-templated transcription [GO:0006355]; sodium ion transport [GO:0006814] nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890] inorganic cation transmembrane transporter activity [GO:0022890] SRRAPSFPYSYR 1 3.4 0.96165 -1.0743 0 0 0 10.7146 0 0 0 0 0 0 0 0 Q9UN67 PCDBA_HUMAN Protocadherin beta-10 (PCDH-beta-10) PCDHB10 UNQ1906/PRO4352 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] ETVLKISENTAEGTAFR 1 2.1 0.91603 -0.43292 0 0 0 0 0 0 0 12.4235 0 0 0 0 Q9UN70 PCDGK_HUMAN Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43) PCDHGC3 PCDH2 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] MVPEAWRSGLVSTGR;QSRDLYR;RSDPLLKKPGAASPLASR;TPGPSLHADAVR;VQTREDSTKYAELVLER 5 7.4 0.97809 -2.1634 0 12.1454 0 5.22242 9.94405 0 0 0 4.53207 8.2213 0 0 Q9UN71 PCDGG_HUMAN Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2) PCDHGB4 CDH20 FIB2 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LEGDVPFK;LVTDAVLDREQNPEYNITVTATDR 2 3.5 0.87677 -0.13388 0 11.8455 0 0 0 0 0 0 0 0 0 0 Q9UN72 PCDA7_HUMAN Protocadherin alpha-7 (PCDH-alpha-7) PCDHA7 CNRS4 Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] EELCGRSAECSIHLEVIVERPLQVFHVDVEVK;NYYSLVLDSALDR;RQRVCSGEGPPK 3 6.1 0.87651 -0.12607 0 0 0 0 0 0 9.27001 0 0 0 0 7.29517 Q9UN73 PCDA6_HUMAN Protocadherin alpha-6 (PCDH-alpha-6) PCDHA6 CNRS2 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LGKQCLLLPLLLLAAWK;NYYSLVLDSALDR;RQRVCSGEGPPK 3 4.4 0.92115 -0.43901 0 0 0 0 5.00437 0 0 0 0 0 0 0 Q9UN75 PCDAC_HUMAN Protocadherin alpha-12 (PCDH-alpha-12) PCDHA12 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] NYYSLVLDSALDR;SILPELVLRKLLDR 2 2.9 0.86836 -0.090725 0 0 0 0 0 6.41192 0 0 0 0 0 0 Q9UN79 SOX13_HUMAN Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) SOX13 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; cell fate commitment [GO:0045165]; gamma-delta T cell differentiation [GO:0042492]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" DVKGTQESLAEK;SMTNQEK;YPDYKYKPRPK 3 4.8 0.95516 -0.87838 0 0 10.6636 0 0 0 0 0 0 4.87199 0 0 Q9UN81 LORF1_HUMAN LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) L1RE1 LRE1 Homo sapiens (Human) retrotransposition [GO:0032197] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727] GKEVENFEK;LSFISEGEIKYFIDKQMLR 2 8.3 0.50085 0.18909 0 0 0 0 10.9452 0 11.1636 0 0 0 0 0 Q9UN86 G3BP2_HUMAN Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) G3BP2 KIAA0660 Homo sapiens (Human) cytoplasmic sequestering of NF-kappaB [GO:0007253]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; positive regulation of stress granule assembly [GO:0062029]; protein homooligomerization [GO:0051260]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829] molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor complex adaptor activity [GO:0030159] GDMEQNDSDNR 1 2.3 0.89749 -0.23907 0 0 0 0 0 0 0 5.09993 0 0 0 0 Q9UNA0 ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2) ADAMTS5 ADAMTS11 ADMP2 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; defense response to bacterium [GO:0042742]; endocardial cushion morphogenesis [GO:0003203]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; negative regulation of cold-induced thermogenesis [GO:0120163]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270] CGVCGGDNSSCTK;FTAYLALKK;GCPLSQRPSAFKQCLLK 3 4.2 0.95488 -0.87909 0 0 0 0 6.65363 0 0 0 10.1849 7.81513 0 0 Q9UNA1 RHG26_HUMAN Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) ARHGAP26 GRAF KIAA0621 OPHN1L Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; mitophagy [GO:0000423]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739] GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; protein-macromolecule adaptor activity [GO:0030674] HLNLSSK;IVGVNSRVQK;TASETETDICAEWEIK;YDKETEK 4 4.9 0.98058 -1.6762 0 0 0 0 8.98638 0 0 0 0 0 9.6643 0 Q9UNA3 A4GCT_HUMAN "Alpha-1,4-N-acetylglucosaminyltransferase (Alpha4GnT) (EC 2.4.1.-)" A4GNT Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; epithelial cell proliferation [GO:0050673]; glycoprotein biosynthetic process [GO:0009101]; negative regulation of epithelial cell proliferation [GO:0050680]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375] CLNISFLHPQRFYPISYR 1 5.3 0.91985 -0.4378 0 0 0 0 0 0 0 9.73953 0 0 0 0 Q9UNA4 POLI_HUMAN DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) POLI RAD30B Homo sapiens (Human) DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; translesion synthesis [GO:0019985] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] ALNTAKK;DERISQGPK;DLQTFSPK 3 3.2 0.96439 -1.1168 0 11.2796 0 10.0622 9.32784 0 12.504 0 0 0 0 0 Q9UND3 NPIA1_HUMAN Nuclear pore complex-interacting protein family member A1 (Nuclear pore complex-interacting protein) (NPIP) NPIPA1 NPIP Homo sapiens (Human) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] IVLEDIFTLWRQVETKVR 1 5.1 0.54903 0.18354 0 0 0 0 0 0 0 0 0 0 8.05582 0 Q9UNE2 RPH3L_HUMAN Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) RPH3AL NOC2 Homo sapiens (Human) calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion [GO:0032024] cytoplasm [GO:0005737]; presynapse [GO:0098793]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] AKLQTGWSVHTYQTEK;CGIEASPGQKRPLWLCK;IGRLVER;SSETSRIYTWAR 4 16.5 0.97651 -2.249 0 11.5146 9.39663 0 0 0 0 0 0 0 8.30647 0 Q9UNE7 CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) STUB1 CHIP PP1131 Homo sapiens (Human) cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to misfolded protein [GO:0071218]; DNA repair [GO:0006281]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; ERBB2 signaling pathway [GO:0038128]; MAPK cascade [GO:0000165]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of mitophagy [GO:1901526]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of proteolysis [GO:0045862]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein maturation [GO:0051604]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of glucocorticoid metabolic process [GO:0031943]; regulation of protein stability [GO:0031647]; response to ischemia [GO:0002931]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018] enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; misfolded protein binding [GO:0051787]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] IHQESELHSYLSRLIAAERER 1 6.9 0.52431 0.18665 0 0 0 8.61014 0 0 0 0 0 0 0 0 Q9UNF0 PACN2_HUMAN Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) PACSIN2 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; regulation of endocytosis [GO:0030100] caveola [GO:0005901]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587] cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phospholipid binding [GO:0005543] AADAVEDLR;EAFHKQMMGGFK;MEDEDEQGWCK;QMMGGFK;VSELHLEVK 5 8.4 0.98158 -1.7711 0 4.58123 0 0 0 0 0 0 7.7847 11.8235 0 6.69446 Q9UNF1 MAGD2_HUMAN Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) MAGED2 BCG1 Homo sapiens (Human) female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; renal sodium ion absorption [GO:0070294] cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] KVSHVADTKVNTK;LAAWARRALLSLR;SLAADTK;VLKFACK;VQKKDPK 5 7.8 0.97495 -3.8943 0 0 0 0 9.29149 13.1153 0 0 10.8297 0 0 0 Q9UNH5 CC14A_HUMAN Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) cell division [GO:0051301]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]; sensory perception of sound [GO:0007605] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; kinocilium [GO:0060091]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; stereocilium tip [GO:0032426] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" AGFTASPFTNLLNGSSQPTTR 1 3.5 0.64925 0.1709 0 0 5.02334 7.97516 0 0 0 0 0 0 0 0 Q9UNH7 SNX6_HUMAN "Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]" SNX6 Homo sapiens (Human) "cellular response to amyloid-beta [GO:1904646]; cellular response to epidermal growth factor stimulus [GO:0071364]; intracellular protein transport [GO:0006886]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde transport, endosome to Golgi [GO:0042147]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; nucleus [GO:0005634]; postsynaptic early endosome [GO:0098842]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; tubular endosome [GO:0097422]" dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; type I transforming growth factor beta receptor binding [GO:0034713] LEDFFKNMVK;LSDLLKYYLR;YYLRESQAAK 3 6.4 0.97207 -2.6992 0 0 7.85 0 0 0 0 9.04169 0 9.07986 0 0 Q9UNK0 STX8_HUMAN Syntaxin-8 STX8 Homo sapiens (Human) cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625] SSLMSEEAK 1 3.8 0.90929 -0.31456 0 0 0 0 0 0 0 0 0 9.73905 0 0 Q9UNL2 SSRG_HUMAN Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) SSR3 TRAPG Homo sapiens (Human) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] APKGSSK;FDSCLKYGHHK;KLSEADNRK 3 13.6 0.98164 -1.7704 11.0733 0 0 0 0 0 0 12.095 0 0 0 0 Q9UNL4 ING4_HUMAN Inhibitor of growth protein 4 (p29ING4) ING4 My036 Homo sapiens (Human) "apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; DNA replication-dependent chromatin disassembly [GO:0140889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA-templated transcription [GO:0006355]" cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713] DLDQRTEDLK 1 4 0.98062 -1.5949 0 0 0 0 0 0 0 0 10.2826 0 0 0 Q9UNM6 PSD13_HUMAN 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) PSMD13 Homo sapiens (Human) meiosis I [GO:0007127]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" structural molecule activity [GO:0005198] VHMTWVQPR;VLDLQQIK;VLDLQQIKGMKDR 3 5.9 0.98002 -1.8385 0 0 0 0 0 0 0 0 11.7379 10.05 0 0 Q9UNN4 TF2AY_HUMAN "TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor)" GTF2A1L ALF GTF2A1LF Homo sapiens (Human) cognition [GO:0050890]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] DSNSQVDLSIR;MACLNPVPK 2 4.2 0.91344 -0.38685 0 0 0 0 0 0 0 0 0 0 11.3159 0 Q9UNN5 FAF1_HUMAN FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) FAF1 UBXD12 UBXN3A CGI-03 Homo sapiens (Human) apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; ERAD pathway [GO:0036503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176] CD95 death-inducing signaling complex [GO:0031265]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ooplasm [GO:1990917]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] FLTMCNR;QIVERQPRMLDFR;VEYRDRNVDVVLEDTCTVGEIK 3 6.5 0.97427 -3.0538 0 0 0 0 0 0 10.28 0 0 11.4528 0 0 Q9UNN8 EPCR_HUMAN Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201) PROCR EPCR Homo sapiens (Human) blood coagulation [GO:0007596]; negative regulation of coagulation [GO:0050819] cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] TLAFPLTIR 1 3.8 0.9353 -0.52897 0 0 0 11.6812 0 0 0 0 0 0 0 0 Q9UNP9 PPIE_HUMAN Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) PPIE CYP33 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; regulation of DNA-templated transcription [GO:0006355]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; U2-type catalytic step 2 spliceosome [GO:0071007] cyclosporin A binding [GO:0016018]; mRNA binding [GO:0003729]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] QEESAITSQPR 1 3.7 0.91614 -0.4315 0 0 0 0 0 0 0 9.66256 0 0 0 0 Q9UNQ2 DIM1_HUMAN "Dimethyladenosine transferase (EC 2.1.1.183) (18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (18S rRNA dimethylase) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)" DIMT1 DIMT1L HUSSY-05 Homo sapiens (Human) positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity [GO:0052909]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" IHCSVHNIIIPEDFSIADK;VDHLMKVGKNNFRPPPK 2 11.5 0.96388 -1.0943 0 0 0 9.42249 0 0 0 0 0 0 0 8.99839 Q9UNS1 TIM_HUMAN Protein timeless homolog (hTIM) TIMELESS TIM TIM1 TIMELESS1 Homo sapiens (Human) branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; identical protein binding [GO:0042802] CQPRSFLR 1 0.7 0.91318 -0.33804 10.4892 0 0 0 0 0 0 0 0 0 0 0 Q9UNS2 CSN3_HUMAN COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) COPS3 CSN3 Homo sapiens (Human) "in utero embryonic development [GO:0001701]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902162]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]" COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ASALEQFVNSVR;KYILVSLILLGK;YILVSLILLGKVQQLPK 3 7.1 0 19.955 0 0 0 0 4.38384 0 0 9.03312 10.8858 5.31408 0 8.26162 Q9UNT1 RBL2B_HUMAN Rab-like protein 2B RABL2B Homo sapiens (Human) cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; pericentriolar material [GO:0000242] GTP binding [GO:0005525]; GTPase activity [GO:0003924] KVTYRNLSTWYTELR;MAEDKTKPSELDQGK 2 13.2 0.93384 -0.51144 0 0 7.19722 0 0 0 0 4.65461 0 0 0 0 Q9UNU6 CP8B1_HUMAN 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (EC 1.14.14.139) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase) (CYPVIIIB1) (Cytochrome P450 8B1) (Sterol 12-alpha-hydroxylase) CYP8B1 CYP12 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; positive regulation of intestinal cholesterol absorption [GO:0045797]; response to cholesterol [GO:0070723]; response to nutrient levels [GO:0031667]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity [GO:0033779]; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity [GO:0033778]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; sterol 12-alpha-hydroxylase activity [GO:0008397]" FDLLFPRFVYSLLWPR;TGKKIHHYTMPWGSGVSICPGR 2 7.6 0.66012 0.16922 0 0 3.22507 0 7.33011 0 10.2097 0 9.48541 0 8.48091 0 Q9UNW1 MINP1_HUMAN "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) bone mineralization [GO:0030282]; inositol phosphate metabolic process [GO:0043647]; intracellular monoatomic cation homeostasis [GO:0030003]; ossification [GO:0001503] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] "3-phytase activity [GO:0016158]; 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol pentakisphosphate phosphatase activity [GO:0052827]; inositol phosphate phosphatase activity [GO:0052745]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity [GO:0030352]; inositol-hexakisphosphate phosphatase activity [GO:0004446]" APGCLLR;QYWKRGYGYTINSR 2 4.3 0.97079 -1.3387 0 0 0 0 0 0 0 0 0 0 10.6805 10.9034 Q9UNW8 GP132_HUMAN Probable G-protein coupled receptor 132 (G2 accumulation protein) GPR132 G2A Homo sapiens (Human) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] SIKQSMGLSAAQK;WTLGLLACK 2 5.8 0.95575 -0.94086 0 0 10.449 0 0 0 11.957 0 0 0 0 0 Q9UNW9 NOVA2_HUMAN RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) NOVA2 ANOVA NOVA3 Homo sapiens (Human) "central nervous system neuron development [GO:0021954]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron differentiation [GO:0030182]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of axon guidance [GO:1902667]; regulation of RNA metabolic process [GO:0051252]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] RPLETPPEVVCTK;VTYEQGVRASNPQK 2 5.5 0.81402 -0.0072332 0 0 0 8.25044 0 0 7.28974 0 0 0 0 0 Q9UNX4 WDR3_HUMAN WD repeat-containing protein 3 WDR3 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; snoRNA binding [GO:0030515] FFLSLYGHK;LFNEFIQLGSDVELICR;LSVKQTR;STLQCIR 4 4.2 0.97575 -2.3174 0 0 0 0 0 0 0 0 0 9.60268 4.57307 0 Q9UNY4 TTF2_HUMAN Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) TTF2 Homo sapiens (Human) DNA repair [GO:0006281]; DNA-templated transcription termination [GO:0006353]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369] cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription elongation factor complex [GO:0008023] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]" EEVRCPEHGTFCFLK;IAWARIILDEAHNVKNPR;IYRVGQQKDVVIHR;LFFRCIR;LTLADLR;NQEPALWK;QLIKGEGEEK;RVYLTTQLKQK;VALEFGSEEPR 9 8.7 0.97508 -4.1392 15.3471 0 14.9899 13.1739 12.9809 13.0648 14.4091 13.8202 13.967 12.8508 13.9271 14.2135 Q9UNY5 ZN232_HUMAN Zinc finger protein 232 (Zinc finger and SCAN domain-containing protein 11) ZNF232 ZSCAN11 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSQSSYLSQHR;DHECSECGK;LRWSPAQEESFRQMVVIHK 3 9 0.95233 -0.712 8.65614 0 0 0 0 0 0 10.3753 7.16611 5.95266 12.3119 0 Q9UNZ5 L10K_HUMAN Leydig cell tumor 10 kDa protein homolog C19orf53 HSPC023 Homo sapiens (Human) FQAHKPAK;SKTAAAASEKNR 2 20.2 0.98087 -2.0321 0 0 0 0 0 0 0 0 11.4627 0 0 0 Q9UP38 FZD1_HUMAN Frizzled-1 (Fz-1) (hFz1) (FzE1) FZD1 Homo sapiens (Human) astrocyte-dopaminergic neuron signaling [GO:0036520]; autocrine signaling [GO:0035425]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling [GO:0007267]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; membranous septum morphogenesis [GO:0003149]; midbrain dopaminergic neuron differentiation [GO:1904948]; muscular septum morphogenesis [GO:0003150]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; presynapse assembly [GO:0099054]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410] cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] FYTRLTNSK;LARQLLLLLWLLEAPLLLGVR;QGCEALMNKFGFQWPDTLKCEK;RLARQLLLLLWLLEAPLLLGVR;TLNSWRKFYTR;TVAQGTK;YLMTLIVGITSGFWIWSGKTLNSWR 7 13.3 0.97518 -1.4424 0 0 13.9053 10.4068 0 9.68912 11.5799 0 0 0 0 0 Q9UP65 PA24C_HUMAN Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) PLA2G4C Homo sapiens (Human) arachidonate metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lipid droplet formation [GO:0140042]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; platelet activating factor biosynthetic process [GO:0006663] cell cortex [GO:0005938]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543] HGGIRDK;SENYSLTDFWAYMVISKQTR;TENFLTAVHHGKK;TSLEKQEQPHEDPERK 4 10.2 0.9784 -1.9341 13.4866 7.1235 0 0 0 0 0 0 0 8.92834 0 0 Q9UP79 ATS8_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8) ADAMTS8 METH2 Homo sapiens (Human) extracellular matrix organization [GO:0030198]; negative regulation of cell population proliferation [GO:0008285]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] heparin binding [GO:0008201]; integrin binding [GO:0005178]; low-affinity phosphate transmembrane transporter activity [GO:0009673]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] CGVCGGK;GPEWEVETGEGQR;GTILKYSGSIATLER;LDKCGVCGGKGNSCR;WPPLLLLLLLLLPLAR 5 6.6 0.98061 -1.8006 7.97848 10.2528 6.4298 0 7.88264 0 0 0 0 0 0 0 Q9UP95 S12A4_HUMAN Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) SLC12A4 KCC1 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] EHEEAESGEGTR 1 1.1 0.80746 0.0069469 0 0 0 0 0 0 0 0 5.43729 0 0 0 Q9UPA5 BSN_HUMAN Protein bassoon (Zinc finger protein 231) BSN KIAA0434 ZNF231 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle clustering [GO:0097091] axon [GO:0030424]; cell surface [GO:0009986]; cochlear hair cell ribbon synapse [GO:0098683]; cytoskeleton of presynaptic active zone [GO:0048788]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] enzyme inhibitor activity [GO:0004857]; metal ion binding [GO:0046872]; structural constituent of presynaptic active zone [GO:0098882] AASPTPKQASATTPGHESPR;ALGMDMTTAPR;ATPAELR;HDYVEDSSEGGLSPLPPQPPARAAELTDEDFMR;HGDHGRHSGR;LQEELERERVELQR;VIPDVRVTQHFAKETQDPLK 7 2.9 0.9707 -1.338 0 8.64371 0 0 8.16757 0 8.75208 7.11187 0 10.6369 0 0 Q9UPC5 GPR34_HUMAN Probable G-protein coupled receptor 34 GPR34 Homo sapiens (Human) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930] GEAIFNFILVVMFWLIFLLIILSYIKIGK;GGHNSTMCFHYR;SIQQRKAITTK 3 13.6 0.91319 -0.38339 7.37998 0 0 0 0 8.66324 0 0 0 0 0 0 Q9UPE1 SRPK3_HUMAN SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) SRPK3 MSSK1 STK23 Homo sapiens (Human) cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; muscle tissue development [GO:0060537]; regulation of mRNA processing [GO:0050684]; skeletal muscle tissue development [GO:0007519]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IGDVFNGR 1 1.4 0.9292 -0.48488 0 0 0 0 8.50498 0 0 0 9.15608 0 0 0 Q9UPM8 AP4E1_HUMAN AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) AP4E1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] cargo adaptor activity [GO:0140312] ENSSGYK;SGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGDK 2 4 0.89686 -0.25228 0 9.45695 0 0 0 0 10.8131 0 0 0 0 0 Q9UPN3 MACF1_HUMAN "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 Homo sapiens (Human) Golgi to plasma membrane protein transport [GO:0043001]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of axon extension [GO:0045773]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell migration [GO:0030334]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection arborization [GO:0150011]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; microtubule minus-end binding [GO:0051011]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] AKVVAEQMSRLTPER;CTNFSSCWSDGK;EETVAKMYISELK;EFANFDFDVWRKK;EISLKEFGCKDQR;ELAENKK;ELEALNK;FQVEQIGENKYR;GPLSVVEAIEK;KLNDALDRLEELK;LANSEPVGTQTAKIQQQIIR;LDKQCEMMKAR;LEEEVEACKAR;LETQYCK;LTLAEAK;LYQETAIR;MSELRVTLDPVQLESSLLRSK;NIEPTHAPFIEKSR;RGLNKPSK;SERSCRSER;SSLEATR;TLEQARQLATK;TLLPEDSQK;TLQNQLVELKNHWEELSKK;TTTASPRTPGPKR;TWKERLEK;VDSLIPWIKQHTILMSDKTFPQNPVELK;VEQSYQK;VIEVELAKHHVLK;VTLVEAIEK 30 4.9 0.97897 -15.799 8.58003 11.8961 11.3295 10.1688 12.023 10.062 10.6885 12.642 10.7857 13.9144 12.4279 9.72088 Q9UPN4 CP131_HUMAN Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) CEP131 AZI1 KIAA1118 Homo sapiens (Human) cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; non-motile cilium assembly [GO:1905515]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; regulation of centrosome duplication [GO:0010824]; sperm axoneme assembly [GO:0007288] acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; manchette [GO:0002177]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212] protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] AIGSVPERSPAGVDLSLTGLPPPVSR;AQKASTAER;EALGQQERER;ELMSATEKARR;GLEPEIQK;LEADMALAK;QRAELEELR;QREHYEATIQR 8 8.6 0.9783 -6.3618 0 0 0 0 0 0 0 13.5912 0 0 0 10.4349 Q9UPN6 SCAF8_HUMAN SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) SCAF8 CCAP7 KIAA1116 RBM16 Homo sapiens (Human) "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; termination of RNA polymerase II transcription [GO:0006369]" cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; RNA polymerase II complex binding [GO:0000993] HVVQSVEK;LSSGSYK 2 1.2 0.95211 -0.71155 6.85935 0 0 0 0 0 0 0 0 0 0 7.61677 Q9UPN7 PP6R1_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) PPP6R1 KIAA1115 PP6R1 SAPS1 Homo sapiens (Human) regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; nucleus [GO:0005634] protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; small GTPase binding [GO:0031267] VAGALVQNTEKGPNAEQLR 1 2.2 0.97997 -1.5643 0 0 0 0 9.98797 0 0 0 0 0 0 0 Q9UPN9 TRI33_HUMAN E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; R-SMAD binding [GO:0070412]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DCQLLEHKEHR;LIFKNCER;NYVHFAATQVQNR;SARIGGDGNNK;VAIFTLINEINKKGK 5 5.1 0.97608 -4.5449 8.10282 0 0 0 0 0 0 0 10.1486 10.0839 0 0 Q9UPP1 PHF8_HUMAN Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) PHF8 KIAA1111 ZNF422 Homo sapiens (Human) brain development [GO:0007420]; chromatin remodeling [GO:0006338]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of rDNA heterochromatin formation [GO:0061188]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; chromatin binding [GO:0003682]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] EIDVIDVTR;LGDFVKYYYSGKR;QVIVQAECRQAIHEPK;SLSKSRR;TPGKRPIK 5 5.6 0.97299 -2.5268 0 0 0 8.86022 0 0 10.4893 0 0 0 0 0 Q9UPP2 IQEC3_HUMAN IQ motif and SEC7 domain-containing protein 3 IQSEC3 KIAA1110 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629] guanyl-nucleotide exchange factor activity [GO:0005085] AQAQELQEEEERPGAGAASPR;QIEMLEHK 2 2.5 0.95226 -0.72344 0 0 0 0 0 0 0 0 0 0 0 10.4663 Q9UPQ0 LIMC1_HUMAN LIM and calponin homology domains-containing protein 1 LIMCH1 KIAA1102 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893] cytoplasm [GO:0005737]; stress fiber [GO:0001725] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034] EETESAPRDSER;EVEEEERRYYEEER;GHQIFNR;KLPDVKK;LLQERYQKEQDK;SDGSKQLSK;SNQTAYVPAPLR;SRQTPSPDVVLRGSSDGR;VELVLSQKVVKPK;WQDDLAR;YLRQQSLPPPKFTATVETTIAR 11 9.1 0.97506 -3.186 2.42183 0 4.97939 0 7.18289 0 10.7618 11.5076 0 9.85148 0 0 Q9UPQ0 LIMC1_HUMAN LIM and calponin homology domains-containing protein 1 LIMCH1 KIAA1102 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893] cytoplasm [GO:0005737]; stress fiber [GO:0001725] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034] EVEEEERRYYEEER;KLPDVKK;LLQERYQKEQDK;RSQFFSQSVDSPSSEK;SNQTAYVPAPLR;SRQTPSPDVVLRGSSDGR;VELVLSQKVVKPK;WQDDLAR;YLRQQSLPPPKFTATVETTIAR 9 11.3 0.57489 0.18129 0 0 0 0 0 0 0 0 0 0 0 8.44041 Q9UPQ4 TRI35_HUMAN E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) TRIM35 HLS5 KIAA1098 Homo sapiens (Human) apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DAVTLRCGHNFCR;NMEHALREK;QKQLLADEK;QLTEETEVLAHEIERLQMEMK 4 10.5 0.9747 -3.6229 0 0 0 0 0 0 0 0 12.1408 0 10.0565 11.0195 Q9UPQ7 PZRN3_HUMAN E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IIQINGIEVQNR 1 1.1 0.89801 -0.23831 13.0434 0 0 0 0 0 0 10.4778 0 0 0 0 Q9UPQ9 TNR6B_HUMAN Trinucleotide repeat-containing gene 6B protein TNRC6B KIAA1093 Homo sapiens (Human) "miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulatory ncRNA-mediated gene silencing [GO:0031047]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] RNA binding [GO:0003723] EEQLMEDKKR;VAVPNGQPPSAAR;VTEQKTK 3 1.6 0.98092 -1.7916 0 0 0 0 0 0 0 10.8897 0 7.0217 0 0 Q9UPR0 PLCL2_HUMAN Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) PLCL2 KIAA1092 PLCE2 Homo sapiens (Human) "B cell proliferation involved in immune response [GO:0002322]; B-1a B cell differentiation [GO:0002337]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" cytoplasm [GO:0005737] "GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]" ANDETGE;ELSELVSICKSVQFK;SIKEVRTGK;TVDEVFK;YLISYGK 5 4 0.96501 -1.2366 12.3669 5.44523 0 0 0 7.51491 0 0 0 0 0 0 Q9UPR3 SMG5_HUMAN Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5) SMG5 EST1B KIAA1089 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] histone deacetylase binding [GO:0042826]; protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625] KVYYEVIQLIK;LMRDMAQLR 2 2 0.94435 -0.64006 0 0 0 0 0 3.95838 0 0 0 0 0 10.7917 Q9UPR5 NAC2_HUMAN Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) SLC8A2 KIAA1087 NCX2 Homo sapiens (Human) calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of action potential firing pattern [GO:0099608]; regulation of calcineurin-mediated signaling [GO:0106056]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to ischemia [GO:0002931]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104] axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; synapse [GO:0045202] calcium ion transmembrane transporter activity [GO:0015085]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; sodium ion transmembrane transporter activity [GO:0015081] DLKQKHPDK;GISALLLNQGDGDRK;HAADASR;RLLFYKYVYK;TEDGSAK 5 5.2 0.9324 -0.49428 0 0 0 8.31161 8.88829 0 8.87661 0 8.35685 0 9.93162 0 Q9UPR6 ZFR2_HUMAN Zinc finger RNA-binding protein 2 ZFR2 KIAA1086 Homo sapiens (Human) double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] KVNPDLPIATEPSSRAR;LVSDTLAEEDR 2 3 0.8964 -0.24832 0 0 0 0 0 7.75876 0 0 0 0 0 0 Q9UPS6 SET1B_HUMAN Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) SETD1B KIAA1076 KMT2G SET1B Homo sapiens (Human) methylation [GO:0032259] chromosome [GO:0005694]; cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723] DDDDDDSDDR;DDDDDDSDDRDESENDDEDTALSEASEK;ERMAKASLTPVK;LLSSFTGSCDSDLLK;LNDNIRENFLRDMCK 5 3.6 0.97163 -1.3509 0 4.69259 10.7695 0 0 0 7.82515 0 4.69966 0 0 8.55509 Q9UPS8 ANR26_HUMAN Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) negative regulation of fat cell differentiation [GO:0045599] centrosome [GO:0005813] EKTLGLER;KKLNEYENGEFSFHGDLK;LAAAIHDRDQSETSK;LLVEKQQSR;LNSLEIEFHHTR;QEIAEKLKEVNLFLQAQAASQENLEQFR;QLSREQNAR;QLYLEELK;QYQYENEKAER;SLANPGLMKEEPTKPGIAK;YLHLKPTIEMKDSVPNK 11 9 0.97654 -4.9596 11.4813 12.1636 0 10.9323 10.3608 7.47557 8.68275 7.30287 9.97885 0 0 0 Q9UPS8 ANR26_HUMAN Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) negative regulation of fat cell differentiation [GO:0045599] centrosome [GO:0005813] EKTLGLER;KKLNEYENGEFSFHGDLK;LAAAIHDRDQSETSK;LLVEKQQSR;LNSLEIEFHHTR;QEIAEKLKEVNLFLQAQAASQENLEQFR;QLSREQNAR;QLYLEELK;QYQYENEKAER;VEFQALEKEKVQLQK 10 10.5 0.85001 -0.079027 0 0 0 0 0 0 0 0 0 0 0 10.3951 Q9UPT5 EXOC7_HUMAN Exocyst complex component 7 (Exocyst complex component Exo70) EXOC7 EXO70 KIAA1067 Homo sapiens (Human) exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein transmembrane transport [GO:0071806]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]" GFNDGLEELCKIQK;SLMTRHSK;VTDYIAEK 3 4.1 0.98113 -1.7908 10.961 0 0 0 8.3605 0 0 0 10.8432 0 0 0 Q9UPT6 JIP3_HUMAN C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) MAPK8IP3 JIP3 KIAA1066 Homo sapiens (Human) anterograde axonal protein transport [GO:0099641]; axon development [GO:0061564]; axon regeneration [GO:0031103]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JNK cascade [GO:0046330]; protein stabilization [GO:0050821]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471] JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159] EDNEQLLTQYEREK;NQYKERLMELQEAVR;QVREHVR 3 2.7 0.97458 -1.3859 6.32745 0 0 0 0 0 0 0 0 0 0 0 Q9UPT8 ZC3H4_HUMAN Zinc finger CCCH domain-containing protein 4 ZC3H4 C19orf7 KIAA1064 Homo sapiens (Human) "DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]" chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723] AATAGPPNAR;ALYLRIQQKQQEEEER;EGSSRGRGSR;ELNQYRRAK;GEKHHSDSDEEK;SALEQPETGK;YFVEGRCTWGDHCNFSHDIELPK 7 6.9 0.97537 -4.2448 0 0 12.1896 0 0 0 6.59947 0 0 14.3843 4.17816 8.31524 Q9UPU3 SORC3_HUMAN VPS10 domain-containing receptor SorCS3 SORCS3 KIAA1059 Homo sapiens (Human) learning [GO:0007612]; memory [GO:0007613]; neuropeptide signaling pathway [GO:0007218]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of long-term synaptic depression [GO:1900452] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839] neuropeptide receptor activity [GO:0008188] FYWSVAGLDK;GIPAPAK;IVSNNCTDGLREK 3 2.5 0.95203 -0.74405 0 6.82922 0 0 0 0 8.0806 0 0 0 0 0 Q9UPU5 UBP24_HUMAN Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] EARFETTSGK;FLVTLAQK;ITLRVRK;ITVKRTCIK;KLLTSSAVHK;NTFQLLHEILVIEDPIQVERVK;SPHFSAKMNSLKEVTK 7 3.1 0.97512 -3.0839 0 0 0 9.4746 7.94848 10.4912 10.0253 0 0 11.1817 6.92505 0 Q9UPU7 TBD2B_HUMAN TBC1 domain family member 2B TBC1D2B KIAA1055 Homo sapiens (Human) endocytosis [GO:0006897] cytosol [GO:0005829]; early endosome [GO:0005769] GTPase activator activity [GO:0005096] GPLRGYRSR;LQDSMSIFKYLRYFTR;LSEGEGNGPPPTVAPSSPSVVPVAR;TLLGSQVDQR 4 6.2 0.97201 -2.7979 0 0 12.4669 0 0 0 0 0 11.7927 11.7353 11.3689 0 Q9UPU9 SMAG1_HUMAN Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) SAMD4A KIAA1053 SAMD4 SMAUG1 Homo sapiens (Human) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727] cell junction [GO:0030054]; cytosol [GO:0005829]; dendrite [GO:0030425]; fibrillar center [GO:0001650]; P-body [GO:0000932]; synapse [GO:0045202] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371] MFRDQVGVLAGWFK;VSQTQAR 2 2.9 0.96549 -1.161 0 0 0 10.5226 0 0 9.374 0 0 0 0 0 Q9UPV0 CE164_HUMAN Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) cell division [GO:0051301]; cilium assembly [GO:0060271]; DNA repair [GO:0006281] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] ATLSLLQLGLDEHNRVK;EHSAELERLCSSLEAKHR;EKRQEVEGEHER;EVSSSLSQSK;LCQEEEEEILRLHQQKEQSLSSLR;QLGELMLPSQGLK;SEQAALNAAK;SEQAALNAAKEKALQQLR 8 7.7 0.95388 -0.89339 0 0 0 8.50124 9.38645 7.49673 11.2701 8.83235 12.2486 5.90713 10.153 8.04171 Q9UPV7 PHF24_HUMAN PHD finger protein 24 PHF24 KIAA1045 Homo sapiens (Human) "detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic transmission, GABAergic [GO:0032228]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; synaptic vesicle membrane [GO:0030672] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AQHSWFCKR 1 2.2 0.92938 -0.47024 0 0 0 0 0 0 0 0 0 8.76944 0 0 Q9UPV9 TRAK1_HUMAN Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) anterograde axonal transport of mitochondrion [GO:0098957]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; TPR domain binding [GO:0030911] ERGISAAVYDPQSWDRAGR;LKDLEEENVVLR;LLEEKERDLELAAR;QLTAELRELEDK;RFFEEEQERK 5 7 0.85065 -0.078493 0 0 0 0 0 0 0 0 0 0 8.41844 0 Q9UPV9 TRAK1_HUMAN Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) anterograde axonal transport of mitochondrion [GO:0098957]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; TPR domain binding [GO:0030911] LATSTPVQHPETSGER;LKDLEEENVVLR;LLEEKERDLELAAR;QLTAELRELEDK;RFFEEEQERK;VTVSGSR 6 10.3 0.97888 -2.0477 0 0 0 7.55559 8.57096 0 0 10.85 9.27785 6.22674 0 0 Q9UPW0 FOXJ3_HUMAN Forkhead box protein J3 FOXJ3 KIAA1041 Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GLYGQACPSVTSLR 1 2.3 0.78425 0.020168 0 0 0 0 0 0 0 8.2817 0 0 0 0 Q9UPW5 CBPC1_HUMAN Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) AGTPBP1 CCP1 KIAA1035 NNA1 Homo sapiens (Human) adult walking behavior [GO:0007628]; anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; neuromuscular process [GO:0050905]; olfactory bulb development [GO:0021772]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; retina development in camera-type eye [GO:0060041]; retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] EPKPFVFEGKVR;ESPPHEDLMVQIHSILAKIGPK;LKVIPEK;VVVWREIGVQR 4 4.2 0.93383 -0.49861 0 0 0 0 7.53986 0 0 0 0 9.09698 0 0 Q9UPW6 SATB2_HUMAN DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) SATB2 KIAA1034 Homo sapiens (Human) cartilage development [GO:0051216]; chromatin remodeling [GO:0006338]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DRIYQDER;SQGWLCELLRWK;VSQALFAK;WKENPSPENRTLWENLCTIR 4 6.3 0.95974 -1.0452 0 0 0 11.6329 0 0 0 0 0 0 0 0 Q9UPW8 UN13A_HUMAN Protein unc-13 homolog A (Munc13-1) UNC13A KIAA1032 Homo sapiens (Human) "cell differentiation [GO:0030154]; dense core granule priming [GO:0061789]; neuronal dense core vesicle exocytosis [GO:0099011]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075] DFLHGALERDK;ESYSDSMHSYEEFSEPQALSPTGSSR;NKPEIFELIQEIFAVTK;SLLCVGVK 4 3.6 0.9575 -1.0287 7.63633 0 0 0 7.17712 8.25715 0 0 0 0 0 0 Q9UPX0 TUTLB_HUMAN Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B) IGSF9B KIAA1030 Homo sapiens (Human) cell adhesion [GO:0007155]; nervous system development [GO:0007399] neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] VRILIDGTLIIFRVKPEDSGK 1 1.6 0.53073 0.18665 0 0 0 9.20636 0 0 0 0 0 0 0 0 Q9UPX6 MNAR1_HUMAN Major intrinsically disordered Notch2-binding receptor 1 (Membrane integral NOTCH2-associated receptor 1) (Ubiquitination and mTOR signaling protein) MINAR1 KIAA1024 UBTOR Homo sapiens (Human) angiogenesis [GO:0001525]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of TOR signaling [GO:0032007] plasma membrane [GO:0005886] DWRTITYTNRVGLNEEEIK;EDFHNLMAVSPSLVGPISKAENEHR;EVKNRAASLDR;QSSKCRK;VGLNEEEIK 5 6.8 0.97833 -1.9756 0 11.9662 0 0 10.624 10.014 0 0 0 0 0 8.32728 Q9UPX8 SHAN2_HUMAN SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) SHANK2 CORTBP1 KIAA1022 PROSAP1 Homo sapiens (Human) adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786] ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160] CFPAGSDMNSVYER;CIRFNPDATVWVAK;DVLNYGLFQPASNGR;EAPAYSNR;EAPAYSNRR;MNIERALK;RNSPAFLSTDLGDEDVGLGPPAPR;VGHRQVVNMIR;VVIHDLQQTKCIR 9 5.7 0.97483 -3.5521 12.335 0 0 6.85649 6.12549 6.53289 0 10.6439 0 11.3227 8.82807 10.8777 Q9UPX8 SHAN2_HUMAN SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) SHANK2 CORTBP1 KIAA1022 PROSAP1 Homo sapiens (Human) adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786] ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160] CFPAGSDMNSVYER;EAPAYSNR;EAPAYSNRR;EVPFREAPAYSNRR;MNIERALK;RNSPAFLSTDLGDEDVGLGPPAPR;VGHRQVVNMIR 7 4.8 0.48532 0.18987 0 0 0 0 0 7.85212 0 0 0 0 0 0 Q9UPY3 DICER_HUMAN Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) DICER1 DICER HERNA KIAA0928 Homo sapiens (Human) apoptotic DNA fragmentation [GO:0006309]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; negative regulation of gene expression [GO:0010629]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; tRNA decay [GO:0016078] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; pre-miRNA binding [GO:0070883]; protein domain specific binding [GO:0019904]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; siRNA binding [GO:0035197] FMEDIEK;FVTPKVIKLLEILR;KQEEVLR;SEEDEEK;SFEEDLK;VAGMMVR 6 2.5 0.981 -1.7291 0 11.3725 0 0 9.75569 0 0 0 5.80072 0 9.99365 5.41414 Q9UPY3 DICER_HUMAN Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) DICER1 DICER HERNA KIAA0928 Homo sapiens (Human) apoptotic DNA fragmentation [GO:0006309]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; negative regulation of gene expression [GO:0010629]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; tRNA decay [GO:0016078] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; pre-miRNA binding [GO:0070883]; protein domain specific binding [GO:0019904]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; siRNA binding [GO:0035197] LAWESDHFLR;SEEDEEK 2 2.1 0.78099 0.032574 0 0 0 0 0 0 0 0 0 0 0 9.77395 Q9UPY5 XCT_HUMAN Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) SLC7A11 Homo sapiens (Human) adult behavior [GO:0030534]; amino acid transmembrane transport [GO:0003333]; cellular response to oxidative stress [GO:0034599]; dipeptide import across plasma membrane [GO:0140206]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; intracellular glutamate homeostasis [GO:0090461]; L-cystine transport [GO:0015811]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; L-kynurenine transmembrane transport [GO:0140924]; lens fiber cell differentiation [GO:0070306]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ferroptosis [GO:0110076]; platelet aggregation [GO:0070527]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cysteine metabolic process [GO:1901494]; regulation of glutamate metabolic process [GO:2000211]; regulation of glutathione biosynthetic process [GO:1903786]; regulation of melanin biosynthetic process [GO:0048021]; regulation of neutrophil apoptotic process [GO:0033029]; regulation of protein transport [GO:0051223]; regulation of synapse organization [GO:0050807]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to redox state [GO:0051775]; response to toxic substance [GO:0009636]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual learning [GO:0008542] apical part of cell [GO:0045177]; astrocyte projection [GO:0097449]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] cystine:glutamate antiporter activity [GO:0015327]; L-amino acid transmembrane transporter activity [GO:0015179]; L-kynurenine transmembrane transporter activity [GO:0140926] GGYLQGNVNGRLPSLGNK;IQIFLTFCKLTAILIIIVPGVMQLIK;ITRTLQIILEVVPEEDKL;YILEPFFIQCEIPELAIK 4 16 0.93588 -0.5286 7.00697 0 0 0 9.82003 0 0 0 0 8.47037 0 0 Q9UPY6 WASF3_HUMAN Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) WASF3 KIAA0900 SCAR3 WAVE3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; modification of postsynaptic actin cytoskeleton [GO:0098885]; oligodendrocyte development [GO:0014003]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of myelination [GO:0031643]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360] cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; SCAR complex [GO:0031209] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237] QEWNMMAYDK 1 2 0.89603 -0.23676 0 0 8.79529 0 0 0 0 0 0 0 0 0 Q9UPZ3 HPS5_HUMAN BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) HPS5 AIBP63 KIAA1017 Homo sapiens (Human) blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155] BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769] ESVSSFVRKTTEK;LEHLKSQLDHGTYNDLISQLEELILK;RVTALCWDTAILRVFVGDHAGK;SCGFWPGYLILCLELERR 4 7 0.98013 -1.5554 0 7.52865 0 0 0 0 0 11.7594 0 10.3407 0 0 Q9UPZ6 THS7A_HUMAN "Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]" THSD7A KIAA0960 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154] cell projection [GO:0042995]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] ECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECR;ELYDWRLGPWNQCQPVISKSLEKPLECIK;SCNPPCSQPHSYCSETK;SCYDGQCYEYK;SVDLKYCEALGLEK;VNVGQVGPK 6 6.9 0.95188 -0.74616 0 0 0 0 0 0 9.07652 6.90893 7.24394 10.0386 5.85482 4.77357 Q9UPZ9 CILK1_HUMAN Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) CILK1 ICK KIAA0936 Homo sapiens (Human) cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ENDHLYFIFEYMKENLYQLIKER 1 3.6 0.59846 0.17852 6.29013 0 0 0 0 0 0 0 0 0 0 0 Q9UQ03 COR2B_HUMAN Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96) CORO2B KIAA0925 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of establishment of protein localization [GO:1904950]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of protein localization [GO:1904951]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cellular response to stress [GO:0080135]; regulation of glomerular filtration [GO:0003093] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020] actin binding [GO:0003779]; actin filament binding [GO:0051015]; talin binding [GO:1990147]; vinculin binding [GO:0017166] GLGVMPK;GLIEPISMIVPRR;HGLDVSACEVFRFYK;NLRNSPKNC;TVTKMSWRPQYR;VIEPRSGR 6 13.3 0.97494 -4.1128 0 0 0 0 8.55278 10.204 12.1229 0 0 9.45249 8.88664 10.7132 Q9UQ05 KCNH4_HUMAN Voltage-gated delayed rectifier potassium channel KCNH4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Potassium voltage-gated channel subfamily H member 4) (Voltage-gated potassium channel subunit Kv12.3) KCNH4 Homo sapiens (Human) potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] ADIAMHLNR;AEICFYRKDGSAFWCLLDMMPIK;AGLPRDLTFNLR;IVDGIEDSGSTAEAPSFRFSRRPELPRPR;LLRLLRLLQK;LNQEVSQLSR;LTGHFGR;SLYHSRMK 8 10.6 0.97613 -4.538 12.5056 12.3799 12.1423 0 0 11.3229 0 10.7158 8.34087 14.3222 0 0 Q9UQ07 MOK_HUMAN MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] IMHYMYQLCK;QEEDRPKR;RGPAYVMELPK;TDPQKDLKPAPQQCRLPTIVR;VPVLRPLK 5 13.8 0.96562 -1.1479 0 9.43613 0 0 0 0 0 0 0 8.43813 10.5516 6.62473 Q9UQ13 SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) SHOC2 KIAA0862 Homo sapiens (Human) cellular response to growth hormone stimulus [GO:0071378]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular signal transduction [GO:0035556]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164] protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; volume-sensitive anion channel activity [GO:0005225] ASGGFGK;ELDLEENK;ELNKCREENSMR;LGLRYNR 4 5.8 0.975 -3.1867 0 0 0 0 0 0 0 0 0 8.65231 11.1833 0 Q9UQ16 DYN3_HUMAN "Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)" DNM3 KIAA0820 Homo sapiens (Human) endocytosis [GO:0006897]; filopodium assembly [GO:0046847]; negative regulation of dendritic spine morphogenesis [GO:0061002]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of synaptic vesicle recycling [GO:1903423]; receptor internalization [GO:0031623]; synapse assembly [GO:0007416]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185] apical tubulobulbar complex [GO:0061828]; axon [GO:0030424]; basal tubulobulbar complex [GO:0061829]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; dendritic spine head [GO:0044327]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone membrane [GO:0098844]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic cleft [GO:0043083] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; nitric-oxide synthase binding [GO:0050998]; protein serine/threonine kinase binding [GO:0120283]; structural constituent of postsynapse [GO:0099186]; type 1 metabotropic glutamate receptor binding [GO:0031798]; type 5 metabotropic glutamate receptor binding [GO:0031802] CIRDLIPKTIMHLMINNVK;NFKPEDPTRK;NLVDSYMSIINKCIRDLIPK 3 4.7 0.87525 -0.12032 9.81223 0 0 0 11.0043 0 0 0 0 10.7859 10.9659 0 Q9UQ26 RIMS2_HUMAN Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) RIMS2 KIAA0751 RAB3IP3 RIM2 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082] cell projection [GO:0042995]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; transmembrane transporter binding [GO:0044325] QGLGGASAAGRSMQRSQSR 1 6.7 0.50297 0.18874 8.40757 6.74564 0 6.69028 0 7.43663 0 0 0 0 7.35658 6.97476 Q9UQ26 RIMS2_HUMAN Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) RIMS2 KIAA0751 RAB3IP3 RIM2 Homo sapiens (Human) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082] cell projection [GO:0042995]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; transmembrane transporter binding [GO:0044325] EDGRPRNPYVKIYFLPDR;EEEKEQSVLKK;EYIVDDEDVESRDEYER;GLRNEEAPQEK;LHQQFEMYKEQVKK;LIGRILLNKR;QHSIKNGSGVK;SNKVMWVCNLCR;SNKVMWVCNLCRK 9 7.8 0.97307 -2.5693 8.54249 0 7.22352 9.59498 9.68802 0 7.82197 14.7776 0 0 8.91415 0 Q9UQ35 SRRM2_HUMAN Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) SRRM2 KIAA0324 SRL300 SRM300 HSPC075 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005] C2H2 zinc finger domain binding [GO:0070742]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ETPSPRPMRHRSSR;GRGPSPEGSSSTESSPEHPPK;KHRSESESK;MALPPQEDATASPPR;QKSKTPSR;SLSGSSPCPK;SLSYSPVER;SRSPSSPELNNK;SSTGPEPPAPTPLLAER;TPAIPTAVNLADSR;TPLLPRK;TPQAPASANLVGPR;TPTAPAVNLAGAR;TPTTRRR;VTSRTTPR;VTSRTTPRR 16 6.5 0.97809 -8.0097 0 0 9.08614 8.74594 0 0 0 11.5325 2.1989 9.09117 9.58111 11.5241 Q9UQ49 NEUR3_HUMAN Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) NEU3 Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; ganglioside catabolic process [GO:0006689]; glycosphingolipid catabolic process [GO:0046479]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; oligosaccharide catabolic process [GO:0009313]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742] caveola [GO:0005901]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] alpha-sialidase activity [GO:0016997]; exo-alpha-sialidase activity [GO:0004308] DEDALHLVLR;GITYRIPALLYIPPTHTFLAFAEKR 2 8.2 0.87407 -0.10513 0 8.58376 0 0 0 0 0 0 4.98249 0 0 0 Q9UQ52 CNTN6_HUMAN Contactin-6 (Neural recognition molecule NB-3) (hNB-3) CNTN6 Homo sapiens (Human) axon guidance [GO:0007411]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; synapse organization [GO:0050808] axon [GO:0030424]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] GVAHFERIGGESVGDLMIRNIQLHHSGK;IGGESVGDLMIR 2 2.7 0.8487 -0.077327 0 0 0 0 0 8.86552 0 0 10.7838 0 0 0 Q9UQ53 MGT4B_HUMAN "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)" MGAT4B UNQ906/PRO1927 Homo sapiens (Human) N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] "acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]" TDVNELLQRWTPRCVR 1 2.8 0.43132 0.19493 0 0 0 7.72479 0 0 0 0 0 0 0 0 Q9UQ80 PA2G4_HUMAN Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) PA2G4 EBP1 Homo sapiens (Human) negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625] AFFSEVER;ALLQSSASR;ITSGPFEPDLYK;KARMGVVECAK;QHVIDGEK;SDQDYILK;SGEDEQQEQTIAEDLVVTK;TAENATSGETLEENEAGD;TIIQNPTDQQK 9 26.4 0 10.848 0 12.5155 10.5067 0 9.38392 0 0 9.03785 0 11.9177 10.995 0 Q9UQ84 EXO1_HUMAN Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) EXO1 EXOI HEX1 Homo sapiens (Human) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; somatic hypermutation of immunoglobulin genes [GO:0016446]; t-circle formation [GO:0090656] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA 5'-3' DNA exonuclease activity [GO:0051908]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; metal ion binding [GO:0046872]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145] LNELWKNFGFK 1 1.3 0.95283 -0.67676 0 0 0 10.4393 0 0 0 0 0 0 0 0 Q9UQ90 SPG7_HUMAN Mitochondrial inner membrane m-AAA protease component paraplegin (EC 3.4.24.-) (EC 3.6.-.-) (Cell matrix adhesion regulator) (Paraplegin) (Spastic paraplegia 7 protein) SPG7 CAR CMAR PGN Homo sapiens (Human) anterograde axonal transport [GO:0008089]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; mitochondrial protein processing [GO:0034982]; nervous system development [GO:0007399]; proteolysis [GO:0006508]; regulation of calcium import into the mitochondrion [GO:0110097]; regulation of mitochondrial membrane permeability [GO:0046902] axon cytoplasm [GO:1904115]; m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent peptidase activity [GO:0004176]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] AVLLLLLRALR;AVLLLLLRALRR;AYRHTEKVLQDNLDK;EIFEQHLKSLKLTQSSTFYSQR;LAGMTGR;VLQDNLDK 6 7 0.95208 -0.71014 0 7.75922 10.0311 0 4.90588 0 9.89022 7.78829 9.26224 9.53319 0 8.97353 Q9UQB3 CTND2_HUMAN Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) CTNND2 NPRAP Homo sapiens (Human) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; dendritic spine morphogenesis [GO:0060997]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; Wnt signaling pathway [GO:0016055] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] ALQSPEHHIDPIYEDR;NCGGIPALVR 2 2.1 0.93723 -0.56243 0 0 0 0 0 0 0 0 8.47098 0 0 0 Q9UQC2 GAB2_HUMAN GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) GAB2 KIAA0571 Homo sapiens (Human) osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell degranulation [GO:0043306]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]" ASSCETYEYPQR 1 1.8 0.80773 0.0073321 0 0 0 0 0 0 0 0 0 0 6.67059 0 Q9UQC9 CLCA2_HUMAN "Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]" CLCA2 CACC3 Homo sapiens (Human) cell adhesion [GO:0007155]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508] anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] KYYTNNFITNLTFR 1 1.5 0.65254 0.17 0 0 0 8.80639 0 0 0 0 0 0 0 0 Q9UQD0 SCN8A_HUMAN Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) SCN8A MED Homo sapiens (Human) action potential [GO:0001508]; cardiac muscle cell action potential involved in contraction [GO:0086002]; myelination [GO:0042552]; neuronal action potential [GO:0019228]; optic nerve development [GO:0021554]; peripheral nervous system development [GO:0007422]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] anchoring junction [GO:0070161]; axon [GO:0030424]; axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018] sodium ion binding [GO:0031402]; voltage-gated sodium channel activity [GO:0005248] KLGSKKPQKPIPRPLNK;NSTVDCNGVVSLIGGPGSHIGGR;TFVVLNRGKTLFR;TISVIPGLKTIVGALIQSVK;TLRALRPLRALSR;VLRALKTISVIPGLK 6 4.6 0.73555 0.11115 0 0 9.76452 0 0 0 0 0 0 0 7.45607 0 Q9UQE7 SMC3_HUMAN Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) SMC3 BAM BMH CSPG6 SMC3L1 Homo sapiens (Human) cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]; stem cell population maintenance [GO:0019827] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; dynein complex binding [GO:0070840]; mediator complex binding [GO:0036033]; microtubule motor activity [GO:0003777]; protein heterodimerization activity [GO:0046982] AKDLQDELAGNSEQR;EELAQYQKWDKMR;ISAMKEEK;LEGIITR;LVPGGKATLVMK;QLQQENR;SLDQAINDKKR;SMERWKNMEK;VSFTGKQGEMR;YQTLSLKQLFR 10 8.6 0.97683 -4.9309 8.77073 12.2654 7.41024 9.30243 8.18373 10.2866 9.15568 0 7.96515 0 11.2863 0 Q9UQF0 SYCY1_HUMAN Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)] ERVW-1 ERVWE1 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768] plasma membrane [GO:0005886] MQRPGNIDAPSYRSLSK 1 3.2 0.91841 -0.43584 0 0 0 0 0 0 0 0 0 0 7.45837 0 Q9UQF2 JIP1_HUMAN C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) MAPK8IP1 IB1 JIP1 PRKM8IP Homo sapiens (Human) "JNK cascade [GO:0007254]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of JUN kinase activity [GO:0043508]; positive regulation of JNK cascade [GO:0046330]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of DNA-templated transcription [GO:0006355]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dentate gyrus mossy fiber [GO:0044302]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase inhibitor activity [GO:0004860] AFQQFYK;NISFCGYHPK;STATQMAPPGGPPAAPPGGRGHSHR 3 5.9 0.97489 -1.3851 0 0 0 0 0 0 8.26397 9.40899 0 0 0 0 Q9UQL6 HDAC5_HUMAN Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) HDAC5 KIAA0600 Homo sapiens (Human) "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myotube differentiation [GO:0010830]; regulation of protein binding [GO:0043393]; response to activity [GO:0014823]; response to cocaine [GO:0042220]; response to xenobiotic stimulus [GO:0009410]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor binding [GO:0001222]" LEQQLLILRNKEK;QQQQLQKQLLFAEFQKQHDHLTR 2 3.2 0.74477 0.091091 9.90525 0 6.62125 4.64455 0 0 0 0 0 0 0 0 Q9UQN3 CHM2B_HUMAN Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) CHMP2B CGI-84 Homo sapiens (Human) autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cognition [GO:0050890]; endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; modulation of chemical synaptic transmission [GO:0050804]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; neuron cellular homeostasis [GO:0070050]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of postsynapse organization [GO:0099175]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; protein domain specific binding [GO:0019904] VLAKQLVHLRK 1 5.2 0.86972 -0.094408 0 0 0 0 0 2.81609 0 0 0 0 0 0 Q9UQP3 TENN_HUMAN Tenascin-N (TN-N) (Tenascin-W) (TN-W) TNN TNW Homo sapiens (Human) axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; dendrite self-avoidance [GO:0070593]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of neuron migration [GO:2001223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection extension [GO:1990138]; osteoblast development [GO:0002076]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of bone development [GO:1903010]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of smooth muscle tissue development [GO:1905899] CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; tenascin complex [GO:0090733] identical protein binding [GO:0042802]; integrin binding [GO:0005178] EFWLGLDK;VTENMATVSWDPVQAAIDK;YVVHYTSANGETR 3 3.1 0.9341 -0.51562 0 0 0 9.51481 0 0 0 0 0 0 11.286 7.41371 Q9UQQ1 NALDL_HUMAN Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L) NAALADL1 NAALADASEL NAALADL Homo sapiens (Human) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; membrane [GO:0016020] aminopeptidase activity [GO:0004177]; calcium ion binding [GO:0005509]; carboxypeptidase activity [GO:0004180]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] GAEEDFK;TVAYINVDISVFANATLR;VLGLGLGAAALLGLGIILGHFAIPKK 3 6.9 0.74478 0.09023 0 0 6.35662 0 0 0 0 8.72823 0 7.44857 8.88026 0 Q9UQQ2 SH2B3_HUMAN SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) SH2B3 LNK Homo sapiens (Human) cellular response to chemokine [GO:1990869]; cellular response to interleukin-3 [GO:0036016]; embryonic hemopoiesis [GO:0035162]; erythrocyte development [GO:0048821]; hematopoietic stem cell differentiation [GO:0060218]; intracellular signal transduction [GO:0035556]; megakaryocyte development [GO:0035855]; monocyte homeostasis [GO:0035702]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of response to cytokine stimulus [GO:0060761]; neutrophil homeostasis [GO:0001780]; thrombopoietin-mediated signaling pathway [GO:0038163] cytosol [GO:0005829]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782]; signaling receptor complex adaptor activity [GO:0030159]; stem cell factor receptor binding [GO:0005173]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] APGRDYRDTGR 1 1.9 0.74849 0.084325 0 0 0 0 0 0 0 0 11.901 0 0 0 Q9UQR0 SCML2_HUMAN Sex comb on midleg-like protein 2 SCML2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634]; PcG protein complex [GO:0031519] chromatin binding [GO:0003682]; histone binding [GO:0042393] LCYYIEKLKEGK;NPYLICPATIGDVK;TLNGSEMASATLFKKEPPKPPLNNFK 3 7.4 0.96728 -1.2988 0 0 0 9.92429 0 0 0 0 6.80038 0 0 0 Q9UQR1 ZN148_HUMAN Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) ZNF148 ZBP89 Homo sapiens (Human) cellular defense response [GO:0006968]; gamete generation [GO:0007276]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; substantia nigra development [GO:0021762] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" CDECGMR;GGLLTSEEDSGFSTSPK;NDYLPLYSSSTK;RMCHENHDKK;TNYHLQR 5 6.7 0.95431 -0.91337 0 0 0 5.48265 0 0 0 8.54925 0 10.7591 0 0 Q9XRX5 HHLA3_HUMAN Putative uncharacterized protein ANKRD13C-DT (ANKRD13C divergent transcript) (HERV-H LTR-associating protein 3) (Human endogenous retrovirus-H long terminal repeat-associating protein 3) ANKRD13C-DT HHLA3 Homo sapiens (Human) RIHRVSLVMCVRPLSPSK 1 14.9 0.50707 0.18791 0 0 0 0 0 0 3.25131 0 0 0 0 0 Q9XRX5 HHLA3_HUMAN Putative uncharacterized protein ANKRD13C-DT (ANKRD13C divergent transcript) (HERV-H LTR-associating protein 3) (Human endogenous retrovirus-H long terminal repeat-associating protein 3) ANKRD13C-DT HHLA3 Homo sapiens (Human) GPYPDPK 1 9.2 0.94131 -0.59293 0 8.1058 0 0 0 0 0 0 0 0 0 0 Q9Y210 TRPC6_HUMAN Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) TRPC6 TRP6 Homo sapiens (Human) calcium ion transmembrane transport [GO:0070588]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057] "calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]" GAAGAAAR;IMRGPFMK;SLFYLLLK;YELLEEK 4 3.3 0.97922 -1.8895 0 0 0 0 10.7319 10.6411 11.5792 0 0 11.0891 11.1719 0 Q9Y216 MTMR7_HUMAN "Phosphatidylinositol-3-phosphate phosphatase MTMR7 (EC 3.1.3.64) (Inositol 1,3-bisphosphate phosphatase) (Myotubularin-related protein 7)" MTMR7 Homo sapiens (Human) phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] "inositol bisphosphate phosphatase activity [GO:0016312]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine phosphatase activity [GO:0004725]" LVDRVSPK;TAQVCSVASLLLDPHYR 2 3.8 0.96225 -1.0781 0 0 0 0 0 0 0 0 8.27268 0 0 0 Q9Y217 MTMR6_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR6 Homo sapiens (Human) endocytosis [GO:0006897]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]" EKTYSLWPFLLEDQK;EQTLLPVNDALR;ICETYPR;LLEVNGTK;SEPAVVSLEYGVAR 5 9 0.95846 -1.0044 7.01759 9.7701 8.3062 0 0 0 0 0 11.6972 10.5294 9.17255 0 Q9Y219 JAG2_HUMAN Protein jagged-2 (Jagged2) (hJ2) JAG2 Homo sapiens (Human) auditory receptor cell fate commitment [GO:0009912]; cell differentiation [GO:0030154]; epithelial cell apoptotic process involved in palatal shelf morphogenesis [GO:1990134]; gamma-delta T cell differentiation [GO:0042492]; in utero embryonic development [GO:0001701]; morphogenesis of embryonic epithelium [GO:0016331]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; respiratory system process [GO:0003016]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]; thymic T cell selection [GO:0045061] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; Notch binding [GO:0005112] CDENYYSATCNK;CTCPDGYSGRNCEK;CYDLVNDFYCACDDGWK;EFQCDAYTCSNGGTCYDSGDTFRCACPPGWK 4 6 0.88217 -0.16272 4.78419 7.8999 2.0279 7.58263 0 0 0 0 0 0 0 6.93946 Q9Y221 NIP7_HUMAN 60S ribosome subunit biogenesis protein NIP7 homolog (KD93) (Nucleolar pre-rRNA processing protein NIP7) NIP7 CGI-37 HSPC031 HSPC180 OK/SW-cl.76 OK/SW-cl.78 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255] "cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] GFGVAAK;LAANISGDK;VYYVSEKIMK 3 19.5 0.7837 0.020162 0 6.7389 0 0 0 0 9.01237 10.2894 0 0 9.10347 8.3482 Q9Y222 DMTF1_HUMAN Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1) DMTF1 DMP1 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SEKQCRSK 1 1.1 0.871 -0.095167 0 0 0 0 0 0 0 0 0 0 0 10.8885 Q9Y223 GLCNE_HUMAN Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] GNE GLCNE IBM2 Homo sapiens (Human) CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate biosynthetic process [GO:0046380]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] "ATP binding [GO:0005524]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; N-acylmannosamine kinase activity [GO:0009384]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]" KQLLCSLFQTTLGYR;QLLCSLFQTTLGYR 2 2.1 0.95246 -0.71822 0 0 0 0 0 0 0 0 9.72229 11.3013 0 0 Q9Y228 T3JAM_HUMAN TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) TRAF3IP3 T3JAM Homo sapiens (Human) cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; positive regulation of type I interferon production [GO:0032481] Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674] DLCSLDTQDLQDQLKR;SLENQLYTCTQK;TLRIQQREQLQR;VLLEMEDQKNSYEQKAK 4 10.3 0.96391 -1.1866 8.05615 10.9141 0 0 0 8.54994 0 0 0 0 10.2187 12.2173 Q9Y230 RUVB2_HUMAN RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) RUVBL2 INO80J TIP48 TIP49B CGI-46 Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082] AVLIAGQPGTGK;GLGLDDALEPR;QASQGMVGQLAAR 3 7.8 0.004717 1.4239 10.9928 10.7141 12.4104 0 0 0 0 0 0 10.0841 11.5236 0 Q9Y232 CDYL_HUMAN Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) CDYL CDYL1 Homo sapiens (Human) negative regulation of peptidyl-lysine crotonylation [GO:0120094]; random inactivation of X chromosome [GO:0060816]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] chromatin binding [GO:0003682]; crotonyl-CoA hydratase activity [GO:0120092]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor activity [GO:0003714] ASEELYEVERIVDK 1 2.6 0.88235 -0.17777 0 0 0 6.91157 0 0 0 0 9.45516 0 0 0 Q9Y233 PDE10_HUMAN "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17)" PDE10A Homo sapiens (Human) cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754] cytosol [GO:0005829]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" EDGPSNNASCFRR;FPRGTGLESGTR;IRHSECIYRVTMEK;ISGSAFSK;LCRFIMSVK;NLVNADR;VPYHNWK 7 8.9 0.97504 -3.9538 0 8.12422 9.85128 9.28455 0 0 0 0 0 4.94748 0 0 Q9Y237 PIN4_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4) PIN4 Homo sapiens (Human) rRNA processing [GO:0006364] chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; spindle [GO:0005819] bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] GGGNAVK;GKSGSGK 2 10.7 0.71577 0.13928 0 0 0 4.31339 7.85723 0 11.1009 0 0 0 0 10.6584 Q9Y238 DLEC1_HUMAN Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) cell differentiation [GO:0030154]; defense response to tumor cell [GO:0002357]; negative regulation of cell population proliferation [GO:0008285]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; tubulin binding [GO:0015631] ELNKKLEDSCR;NHFLKNPRFFPPNTR;TSLPNMPPALLKTVR;TVRMQEHLAKR;VCSVRSPAPCGSGAKAPMMR 5 3.9 0.97545 -1.4467 0 0 0 9.52544 0 9.58161 0 0 3.46245 0 9.17255 0 Q9Y239 NOD1_HUMAN Nucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4) NOD1 CARD4 Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to muramyl dipeptide [GO:0071225]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of xenophagy [GO:1904417]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; xenophagy [GO:0098792] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] DSKFVLCYAQK;LLTARTGIEVPR;SPVETLHAGR;YLALAVK 4 4.2 0.9724 -2.7458 0 0 0 12.3579 0 0 0 0 0 5.22207 10.7974 0 Q9Y242 TCF19_HUMAN Transcription factor 19 (TCF-19) (Transcription factor SC1) TCF19 SC1 Homo sapiens (Human) regulation of gene expression [GO:0010468] nucleus [GO:0005634] metal ion binding [GO:0046872] VDKAPLTPTGNRR 1 3.8 0.86492 -0.087619 0 0 0 0 0 0 0 7.75596 0 0 0 0 Q9Y243 AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) AKT3 PKBG Homo sapiens (Human) brain morphogenesis [GO:0048854]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LFELILMEDIK;SDVTIVKEGWVQK;SLLSGLLIKDPNKR;TLSSDAK;YDEDGMDCMDNER 5 12.1 0.95499 -0.96363 7.95076 0 0 8.69108 10.3258 11.3793 8.72509 0 3.16967 0 0 0 Q9Y244 POMP_HUMAN Proteasome maturation protein (Proteassemblin) (Protein UMP1 homolog) (hUMP1) (Voltage-gated K channel beta subunit 4.1) POMP C13orf12 UMP1 HSPC014 HSPC036 PNAS-110 Homo sapiens (Human) proteasome assembly [GO:0043248] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634] NIQGLFAPLKLQMEFK 1 11.3 0.81263 -0.015897 0 0 0 0 0 9.96384 0 0 0 0 0 0 Q9Y248 PSF2_HUMAN DNA replication complex GINS protein PSF2 (GINS complex subunit 2) GINS2 PSF2 CGI-122 DC5 HSPC037 Homo sapiens (Human) DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727] CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EETFTPMPSPYYMELTK;LEKMRDHER;QKCRLLPPEWMDVEK 3 22.2 0.43256 0.19508 0 0 0 6.04293 0 9.51045 0 0 0 7.26482 0 0 Q9Y250 LZTS1_HUMAN Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) LZTS1 FEZ1 Homo sapiens (Human) negative regulation of macroautophagy [GO:0016242]; regulation of dendrite morphogenesis [GO:0048814]; regulation of postsynapse assembly [GO:0150052]; regulation of synaptic plasticity [GO:0048167] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] DELEGPEPKGGNK;GLELEVCENELQRKK;LVWKEEKEK;QLQQSYVAMYQRNQR 4 8.7 0.8322 -0.026179 9.57639 0 0 0 0 0 10.1124 0 8.57815 8.41777 0 0 Q9Y251 HPSE_HUMAN Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) angiogenesis involved in wound healing [GO:0060055]; cell-matrix adhesion [GO:0007160]; establishment of endothelial barrier [GO:0061028]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin metabolic process [GO:0030202]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein transmembrane transport [GO:0071806]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; response to antibiotic [GO:0046677]; vascular wound healing [GO:0061042] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] beta-glucuronidase activity [GO:0004566]; heparanase activity [GO:0030305]; syndecan binding [GO:0045545] EGDLTLYAINLHNVTK;FKNSTYSKPNSFLKK 2 6.4 0.95901 -1.0407 0 0 0 10.8495 0 0 0 0 0 0 0 0 Q9Y252 RNF6_HUMAN E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) RNF6 SPG2 Homo sapiens (Human) axon extension [GO:0048675]; negative regulation of axon extension [GO:0030517]; positive regulation of DNA-templated transcription [GO:0045893]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511] axon [GO:0030424]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; PML body [GO:0016605] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LEPIRLR;LRQLPCMHEFHIHCIDR;TNPNNGEFR 3 4.8 0.91586 -0.33419 0 0 10.1972 0 0 0 0 6.54551 0 0 4.9493 0 Q9Y252 RNF6_HUMAN E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) RNF6 SPG2 Homo sapiens (Human) axon extension [GO:0048675]; negative regulation of axon extension [GO:0030517]; positive regulation of DNA-templated transcription [GO:0045893]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511] axon [GO:0030424]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; PML body [GO:0016605] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] AALPDTS 1 4.9 0.70244 0.16054 0 0 0 0 0 5.96493 0 0 0 0 0 0 Q9Y253 POLH_HUMAN DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV Homo sapiens (Human) cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; pyrimidine dimer repair [GO:0006290]; regulation of DNA repair [GO:0006282]; response to radiation [GO:0009314]; response to UV-C [GO:0010225] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] LSSLRRCCALTR 1 1.7 0.6011 0.17759 0 0 0 0 0 0 0 7.45525 0 0 0 0 Q9Y256 FACE2_HUMAN CAAX prenyl protease 2 (EC 3.4.26.1) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1) RCE1 FACE2 RCE1A RCE1B Homo sapiens (Human) CAAX-box protein processing [GO:0071586]; MAPK cascade [GO:0000165]; protein prenylation [GO:0018342] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222] DHPAVIK 1 2.1 0.90934 -0.31529 0 0 0 0 0 0 10.605 10.2871 0 0 0 0 Q9Y261 FOXA2_HUMAN Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) FOXA2 HNF3B TCF3B Homo sapiens (Human) adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; chromatin organization [GO:0006325]; dopaminergic neuron differentiation [GO:0071542]; endocrine pancreas development [GO:0031018]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of blood coagulation [GO:0030193]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741] cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" CEKQLALKEAAGAAGSGK;SPDKPGK 2 5.5 0.36354 0.23219 0 0 0 8.30766 7.03265 6.45819 6.23018 7.58218 5.87408 5.49994 7.23898 6.26082 Q9Y262 EIF3L_HUMAN Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005 Homo sapiens (Human) formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] LYTTMPVAK;VARRYGDFFIR;YGDFFIR 3 3.5 0.97835 -1.939 0 0 0 0 0 0 0 12.2322 0 11.3305 0 0 Q9Y263 PLAP_HUMAN Phospholipase A-2-activating protein (PLA2P) (PLAP) PLAA PLAP Homo sapiens (Human) cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; nervous system development [GO:0007399]; phospholipid metabolic process [GO:0006644]; positive regulation of dendrite extension [GO:1903861]; positive regulation of neuron migration [GO:2001224]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of synaptic vesicle recycling [GO:1903423]; prostaglandin metabolic process [GO:0006693]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]; ubiquitin recycling [GO:0010992]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; synapse [GO:0045202] phospholipase A2 activator activity [GO:0016005]; ubiquitin binding [GO:0043130] ELNGTAPEEKK;LSCSLRGHELDVR;LTEDDLILLEK 3 4.4 0.96356 -1.109 8.22236 0 0 0 0 0 9.57937 0 0 0 0 8.84235 Q9Y265 RUVB1_HUMAN RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) RUVBL1 INO80H NMP238 TIP49 TIP49A Homo sapiens (Human) box C/D snoRNP assembly [GO:0000492]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713] ALESSIAPIVIFASNR;AVLLAGPPGTGK;EHVEEISELFYDAK;GLGLDESGLAK;ILADQQDKYMK;TALALAIAQELGSK;TMLYTPQEMK;YSVQLLTPANLLAK 8 22.4 0 6.9286 10.1167 11.3893 10.1421 8.07044 7.63001 0 0 9.71908 10.9652 10.2005 10.3199 10.0859 Q9Y266 NUDC_HUMAN Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC Homo sapiens (Human) cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; protein folding [GO:0006457]; response to peptide hormone [GO:0043434] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819] cadherin binding [GO:0045296]; unfolded protein binding [GO:0051082] ELTDEEAER;INKMEWWSR;INKMEWWSRLVSSDPEINTK;LSDLDSETR;LSDLDSETRSMVEK;LVSSDPEINTK;VEESSWLIEDGKVVTVHLEK;WTQTLSELDLAVPFCVNFRLK 8 25.4 0 3.5492 11.3112 9.59391 0 0 0 0 11.9957 11.1765 11.2898 11.1829 9.13771 0 Q9Y267 S22AE_HUMAN Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4) SLC22A14 OCTL2 ORCTL4 Homo sapiens (Human) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] riboflavin transmembrane transporter activity [GO:0032217] AVHTKQDDK;ETSSDDV;LKWPRCPATELK 3 4.7 0.88621 -0.19394 10.3466 3.7 12.1385 9.10939 9.01931 0 0 0 0 11.1131 8.2148 0 Q9Y271 CLTR1_HUMAN Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) CYSLTR1 CYSLT1 Homo sapiens (Human) calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hypoxia [GO:0071456]; chemotaxis [GO:0006935]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; inflammatory response to antigenic stimulus [GO:0002437]; neuropeptide signaling pathway [GO:0007218]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of vasoconstriction [GO:0045907]; respiratory gaseous exchange by respiratory system [GO:0007585] membrane [GO:0016020]; plasma membrane [GO:0005886] cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974] DEKNNTKCFEPPQDNQTK 1 5.3 0.86265 -0.082922 0 0 11.6668 0 0 0 0 0 0 0 0 0 Q9Y274 SIA10_HUMAN "Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.3.6) (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (ST3GalVI) (Sialyltransferase 10)" ST3GAL6 SIAT10 Homo sapiens (Human) cellular response to interleukin-6 [GO:0071354]; glycolipid biosynthetic process [GO:0009247]; keratan sulfate biosynthetic process [GO:0018146]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]" ILDPFIIRTAAYELLHFPK 1 5.7 0.82341 -0.018997 0 0 0 0 0 0 0 10.102 0 10.0554 0 0 Q9Y275 TN13B_HUMAN "Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]" TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738 Homo sapiens (Human) B cell costimulation [GO:0031296]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; germinal center formation [GO:0002467]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of germinal center formation [GO:0002636]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; skin development [GO:0043588]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; transitional one stage B cell differentiation [GO:0002333]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] MDDSTER 1 2.5 0.94149 -0.60275 12.9504 12.6767 0 0 0 0 0 0 0 0 0 0 Q9Y277 VDAC3_HUMAN Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) VDAC3 Homo sapiens (Human) adenine transport [GO:0015853]; behavioral fear response [GO:0001662]; learning [GO:0007612]; neuron-neuron synaptic transmission [GO:0007270]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; synapse [GO:0045202] nucleotide binding [GO:0000166]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308]; voltage-gated monoatomic ion channel activity [GO:0005244] WNTDNTLGTEISWENK 1 5.7 0.93648 -0.55832 0 0 0 0 0 0 0 0 0 0 0 13.3998 Q9Y278 HS3S2_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (3-OST-2) (Heparan sulfate 3-O-sulfotransferase 2) (h3-OST-2) HS3ST2 3OST2 UNQ2442/PRO5004 Homo sapiens (Human) "glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139]; membrane [GO:0016020] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity [GO:0033871]; sulfotransferase activity [GO:0008146] AGPPQPR;RIFNMSR;TPSYFVTQEAPRRIFNMSR 3 7.1 0.96725 -1.3164 0 0 0 10.2476 0 7.82877 0 8.06819 0 0 0 0 Q9Y281 COF2_HUMAN "Cofilin-2 (Cofilin, muscle isoform)" CFL2 Homo sapiens (Human) actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of actin filament depolymerization [GO:0030836]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; I band [GO:0031674]; nuclear matrix [GO:0016363]; Z disc [GO:0030018] actin filament binding [GO:0051015] ASGVTVNDEVIK;EDLVFIFWAPESAPLK;MIYASSK;QIIVEEAK;YALYDATYETK 5 32.5 0.057725 0.44643 0 12.8936 0 0 0 0 0 0 0 10.2902 0 0 Q9Y282 ERGI3_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) ERGIC3 C20orf47 ERV46 SDBCAG84 CGI-54 PRO0989 Homo sapiens (Human) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of intracellular protein transport [GO:0090316]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" "COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]" SRGDKLK 1 1.8 0.81181 -0.014041 0 6.69585 0 0 0 0 0 0 0 0 0 0 Q9Y283 INVS_HUMAN Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS INV NPHP2 Homo sapiens (Human) kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055] cilium [GO:0005929]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] calmodulin binding [GO:0005516] CAPQKRR;LETSTLSEDFQVSK 2 2 0.8119 -0.012871 8.5196 0 0 0 0 0 0 0 0 7.53325 0 0 Q9Y283 INVS_HUMAN Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS INV NPHP2 Homo sapiens (Human) kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055] cilium [GO:0005929]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] calmodulin binding [GO:0005516] TISTGRI 1 6.9 0.77756 0.036703 0 0 0 0 0 0 0 0 8.28378 0 0 0 Q9Y285 SYFA_HUMAN Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) FARSA FARS FARSL FARSLA Homo sapiens (Human) phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] ADGQVAELLLR;EGSHEAR;LDAEPRPPPTQEAA 3 6.3 0.0045977 1.2847 10.5232 9.58626 9.78141 7.6489 8.93006 8.37547 0 0 0 0 0 6.86678 Q9Y286 SIGL7_HUMAN Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) SIGLEC7 AIRM1 Homo sapiens (Human) cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023] EIQYAPLSFHK;FHLLGDPQTKNCTLSIRDAR 2 6.6 0.97508 -1.4574 0 0 0 0 0 10.5879 10.7956 0 0 0 11.8334 11.8625 Q9Y287 ITM2B_HUMAN "Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]" ITM2B BRI BRI2 Homo sapiens (Human) negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524] LTAYLDLNLDK 1 4.1 0.93647 -0.52503 0 0 0 0 0 0 0 0 0 0 10.0279 0 Q9Y295 DRG1_HUMAN Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) DRG1 NEDD3 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle assembly [GO:1901673] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; potassium ion binding [GO:0030955] IAEIEAEMAR;IQLLDLPGIIEGAK;IQLLDLPGIIEGAKDGKGR 3 7.9 0.74504 0.099443 11.8372 0 6.7736 0 0 0 0 0 0 0 0 9.2797 Q9Y297 FBW1A_HUMAN F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] beta-catenin binding [GO:0008013]; ligase activity [GO:0016874]; protein dimerization activity [GO:0046983]; protein phosphorylated amino acid binding [GO:0045309]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] CGRHSLQRIHCR;DPAEAVLQEKALKFMNSSER;EWYRVTSDGMLWKK;IIPEKNSLR;LSASYEK;NSLRQTYNSCAR;VIITGSSDSTVR;VLEGHEELVR;VLEGHEELVRCIR 9 16.7 0.97571 -3.4341 12.4539 0 0 10.2287 0 0 0 7.97963 0 9.31442 7.25937 10.0635 Q9Y2A7 NCKP1_HUMAN Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) NCKAP1 HEM2 KIAA0587 NAP1 Homo sapiens (Human) apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; ruffle [GO:0001726]; SCAR complex [GO:0031209] ASLGLADHR;GEPEREKPGVESMRK;INDIRECK;NLSADQWR 4 3.5 0.95567 -0.81478 11.4614 0 0 0 0 0 7.90701 0 12.341 0 0 0 Q9Y2A9 B3GN3_HUMAN "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Beta3GalT8) (b3Gal-T8) (Beta-3-Gx-T8) (Core 1 extending beta-1,3-N-acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Transmembrane protein 3) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) (BGnT-3) (Beta-1,3-Gn-T3) (Beta-1,3-N-acetylglucosaminyltransferase 3) (Beta3Gn-T3) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8)" B3GNT3 B3GALT8 TMEM3 UNQ637/PRO1266 Homo sapiens (Human) keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" QVLFLQWQETR 1 3 0.87979 -0.14533 0 0 0 0 0 0 0 0 0 7.71959 0 0 Q9Y2B0 CNPY2_HUMAN Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 Homo sapiens (Human) negative regulation of gene expression [GO:0010629]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; regulation of low-density lipoprotein particle clearance [GO:0010988] endoplasmic reticulum [GO:0005783] NGESSELDLQGIR 1 7.1 0.93364 -0.51207 0 0 0 0 0 0 0 9.98128 9.26983 0 0 0 Q9Y2B1 RXLT1_HUMAN "Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.61) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase)" RXYLT1 TMEM5 Homo sapiens (Human) protein O-linked mannosylation [GO:0035269] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "ribitol beta-1,4-xylosyltransferase activity [GO:0120053]" IFYATQWLLYAQNLVQIQK 1 4.3 0.78217 0.022637 0 8.89939 0 0 0 0 0 0 0 0 0 0 Q9Y2B4 T53G5_HUMAN TP53-target gene 5 protein (TP53-inducible gene 5 protein) TP53TG5 C20orf10 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] LRTVLKNLSLLK;TVLKNLSLLKLLK 2 5.2 0.887 -0.19117 0 4.41758 0 0 0 0 3.85569 0 4.39397 0 5.4691 0 Q9Y2B5 VP9D1_HUMAN VPS9 domain-containing protein 1 (Protein ATP-BL) VPS9D1 ATPBL C16orf7 Homo sapiens (Human) proton motive force-driven ATP synthesis [GO:0015986]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] LLCPAQK;LQEAANR 2 2.1 0.96555 -1.1334 0 0 0 0 0 0 0 0 9.29811 0 0 0 Q9Y2C2 UST_HUMAN Uronyl 2-sulfotransferase (EC 2.8.2.-) (Chondroitin sulfate 2-O-sulfotransferase) (CS-2OST) UST DS2ST Homo sapiens (Human) dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; regulation of axonogenesis [GO:0050770] Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity [GO:0102142]; chondroitin 2-O-sulfotransferase activity [GO:0034482]; sulfotransferase activity [GO:0008146] GVLSIYKDPEHRK;MRYEYEFYHYVKEQFHLLK 2 7.9 0.74529 0.096168 0 0 0 8.27417 5.14098 0 0 0 0 0 0 0 Q9Y2C3 B3GT5_HUMAN "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3GALT5 Homo sapiens (Human) lipid metabolic process [GO:0006629]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; response to bacterium [GO:0009617] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" IVACHFIKPR 1 3.2 0.80517 0.013649 0 0 0 0 0 0 0 0 0 7.66576 0 0 Q9Y2C4 EXOG_HUMAN "Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)" EXOG ENDOGL1 ENDOGL2 ENGL Homo sapiens (Human) apoptotic DNA fragmentation [GO:0006309] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 5'-3' exonuclease activity [GO:0008409]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] AKEQSGTQIR;APAGNNK;LSGLVFFPHLDR;MAPAGNNKFSSK 4 14.9 0.94219 -0.59485 0 0 11.1383 9.00596 0 0 3.54671 0 0 0 8.9937 0 Q9Y2C5 S17A4_HUMAN Probable small intestine urate exporter (Solute carrier family 17 member 4) SLC17A4 Homo sapiens (Human) monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] STGPDVK 1 1.4 0.9096 -0.31064 0 0 0 0 0 0 9.31712 0 0 0 0 0 Q9Y2C5 S17A4_HUMAN Probable small intestine urate exporter (Solute carrier family 17 member 4) SLC17A4 Homo sapiens (Human) monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] LFTAIGK;LITIRKLFTAIGK 2 5.9 0.90348 -0.2668 0 9.41952 0 0 0 0 0 9.53794 0 0 0 0 Q9Y2C9 TLR6_HUMAN Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] "amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]" ALMTQRTYLQWPK;VLDLHSNK 2 2.6 0.94208 -0.61956 0 0 0 0 0 10.0753 0 0 0 0 0 0 Q9Y2D0 CAH5B_HUMAN "Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)" CA5B Homo sapiens (Human) one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] MVVMNSLR 1 2.5 0.91361 -0.39033 11.3104 0 0 0 0 0 0 0 0 0 0 0 Q9Y2D1 ATF5_HUMAN Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx) ATF5 ATFX Homo sapiens (Human) cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]" EIQYVKDLLIEVYKAR 1 5.7 0.45364 0.19141 4.57271 0 0 0 0 0 0 0 0 0 0 0 Q9Y2D4 EXC6B_HUMAN Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) EXOC6B KIAA0919 SEC15B SEC15L2 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145] DFLESIRK;ETFENYYR;LIDTVAK;LYGTTTFKDAR;YLRVNPVTALTLLEK 5 6 0.97272 -2.7771 0 0 0 8.53539 0 8.84307 0 0 11.7184 7.05626 0 0 Q9Y2D5 PLAK2_HUMAN PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2) PALM2AKAP2 KIAA0920 PAKAP PALM2 Homo sapiens (Human) regulation of cell shape [GO:0008360] apical plasma membrane [GO:0016324]; side of membrane [GO:0098552] EDIVTEQIDFSAAR;ETEKSFKDFQK;RRQSEEDEFR 3 3.2 0.78267 0.022911 7.64169 0 0 0 0 0 0 0 0 0 0 0 Q9Y2D5 PLAK2_HUMAN PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2) PALM2AKAP2 KIAA0920 PAKAP PALM2 Homo sapiens (Human) regulation of cell shape [GO:0008360] apical plasma membrane [GO:0016324]; side of membrane [GO:0098552] ETEKSFKDFQK;GVKVYDDGTK;RRQSEEDEFR;VVYEVRSGGTVVENGVHK 4 12.9 0.97547 -3.5847 0 0 0 0 0 0 0 11.4688 0 9.99449 0 8.44754 Q9Y2D8 ADIP_HUMAN Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) SSX2IP KIAA0923 Homo sapiens (Human) cell adhesion [GO:0007155]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cell motility [GO:2000145]; regulation of Rac protein signal transduction [GO:0035020] adherens junction [GO:0005912]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] LDNQVSK 1 1.1 0.90889 -0.30921 0 0 8.93198 0 0 0 0 0 0 0 0 0 Q9Y2D9 ZN652_HUMAN Zinc finger protein 652 ZNF652 KIAA0924 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EPKAPVQKAK;KHMVAHTK 2 3 0.97708 -1.4979 0 7.21772 0 0 0 0 0 0 0 0 8.89175 0 Q9Y2E4 DIP2C_HUMAN Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) ADRSLEGMALPLEVR;DLGQIEDNDQARK;DMHWALVAHRDQR;IQQLVNTLKRPKRPPLR;LAELELELSEGDITQK;SSGSRDER;TCVVVAEERPR;VDQALPQER;VSAKIQQLVNTLKRPK 9 6.8 0.97495 -3.9042 11.7491 5.69156 7.87264 0 0 0 12.136 0 0 11.2099 10.159 0 Q9Y2E5 MA2B2_HUMAN "Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2)" MAN2B2 KIAA0935 Homo sapiens (Human) mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] IDYDLKAAMQEAR 1 1.3 0.92191 -0.44693 0 0 0 6.73512 0 0 0 0 0 0 0 0 Q9Y2E6 DTX4_HUMAN E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4) DTX4 KIAA0937 RNF155 Homo sapiens (Human) negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AAVVNGSTGPLQLPVTRKNMPPPGVVK;KVLKLLLVAWDR;SIPGVSNTSR;TPEEVLKKYLQK 4 9.9 0.91148 -0.32494 0 0 0 11.8739 0 0 0 0 5.35113 6.55802 0 10.6942 Q9Y2E8 SL9A8_HUMAN Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) SLC9A8 KIAA0939 NHE8 Homo sapiens (Human) acrosome assembly [GO:0001675]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725] acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] IIEFKKLANWK 1 1.9 0.76785 0.059674 0 0 0 5.77802 0 0 8.15947 0 0 0 0 0 Q9Y2F5 ICE1_HUMAN Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) ICE1 KIAA0947 Homo sapiens (Human) positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] Cajal body [GO:0015030]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] protein-macromolecule adaptor activity [GO:0030674] AIANALKKIAEFSFDLLPVIR;DILHETK;EGGDDTEVESEAFSCSEGSEQQDAPDDSQK;ELWPVMDK;GVTAEGIHK;IRQEVGPPLPPLLAPLIATPPR;RENSNLHHQVEEMLQK 7 5 0.95526 -0.96891 12.8826 0 0 5.92191 0 0 12.7883 9.70957 14.5077 0 11.1679 6.64775 Q9Y2G0 EFR3B_HUMAN Protein EFR3 homolog B EFR3B KIAA0953 Homo sapiens (Human) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ASLLQSK;KHSQQLYRHIYLSCK;LLSTALMEDAEIR;LTQIMLLK;LVDNIFPEDPEDGLVKTNMEK;SYDFFVSR;VDKCSRQDTVFMK 7 10.4 0.98122 -1.691 8.88283 0 0 0 0 0 11.8983 0 0 0 7.54574 9.22904 Q9Y2G1 MYRF_HUMAN "Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]" MYRF C11orf9 KIAA0954 MRF Homo sapiens (Human) central nervous system myelin maintenance [GO:0032286]; central nervous system myelination [GO:0022010]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; protein autoprocessing [GO:0016540] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]" EVVDETEALQR;STGSSGAFSHAGSQFSRAGSVPHK 2 3 0.95125 -0.68648 0 0 0 0 0 0 0 0 6.92077 0 6.41153 0 Q9Y2G2 CARD8_HUMAN "Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]" CARD8 DACAR KIAA0955 NDPP1 Homo sapiens (Human) activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; CARD8 inflammasome complex assembly [GO:0140633]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of apoptotic process [GO:0042981]; self proteolysis [GO:0097264] CARD8 inflammasome complex [GO:0140634]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity [GO:0140608]; molecular condensate scaffold activity [GO:0140693]; NACHT domain binding [GO:0032089]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803] FYAGQMKEPIQLEITEKR;SISERDPYLVSYLRQQNL;VCFEIEEDYKNR 3 8.9 0.84825 -0.072941 0 0 0 9.52009 0 0 0 0 10.8144 0 0 11.6025 Q9Y2G3 AT11B_HUMAN Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) ATP11B ATPIF ATPIR KIAA0956 Homo sapiens (Human) aminophospholipid transport [GO:0015917]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; phospholipid translocation [GO:0045332] azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; monoatomic ion transmembrane transporter activity [GO:0015075]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine floppase activity [GO:0090556] TEHQRNSSK;VIGRCSPTHISR 2 1.8 0.9758 -2.3108 14.5615 0 0 0 0 0 0 0 0 8.98809 8.97022 0 Q9Y2G4 ANKR6_HUMAN Ankyrin repeat domain-containing protein 6 (Diversin) ANKRD6 KIAA0957 Homo sapiens (Human) "negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] LENQLEATVEEIK;LLLTAFCSVHEK;LLVAAYK;LSGDSRACR 4 5.6 0.97581 -1.477 0 0 0 0 0 9.47903 0 0 9.79137 0 0 10.5072 Q9Y2G5 OFUT2_HUMAN GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) POFUT2 C21orf80 FUT13 KIAA0958 Homo sapiens (Human) fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] peptide-O-fucosyltransferase activity [GO:0046922] EYWDTRR 1 1.6 0.91308 -0.38622 0 0 0 0 0 0 0 0 0 0 10.9289 0 Q9Y2G7 ZFP30_HUMAN Zinc finger protein 30 homolog (Zfp-30) (Zinc finger protein 745) ZFP30 KIAA0961 ZNF745 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SCGLEEQESPHEVCFRQVTK 1 3.9 0.95282 -0.67847 0 0 0 0 10.6239 0 0 0 0 0 0 0 Q9Y2G8 DJC16_HUMAN DnaJ homolog subfamily C member 16 (Endoplasmic reticulum DNA J domain-containing protein 8) (ER-resident protein ERdj8) (ERdj8) DNAJC16 ERDJ8 KIAA0962 Homo sapiens (Human) regulation of autophagosome size [GO:0016243] endoplasmic reticulum membrane [GO:0005789] LSLWMERLLEGSLQR 1 1.9 0.81236 -0.011849 0 0 0 0 8.82493 0 0 0 0 0 0 0 Q9Y2G9 SBNO2_HUMAN Protein strawberry notch homolog 2 SBNO2 KIAA0963 Homo sapiens (Human) bone mineralization [GO:0030282]; bone trabecula morphogenesis [GO:0061430]; cellular response to interleukin-11 [GO:0071348]; cellular response to interleukin-6 [GO:0071354]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; macrophage activation involved in immune response [GO:0002281]; negative regulation of DNA-templated transcription [GO:0045892]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727] nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone binding [GO:0042393] DRGAGSK;KKQVGIK;LRHHYMLCGALLR;NGCLDVEKDCSITKFLNR;QVGIKIPEGCVRR;TVAGVILENHLRGR;VAEMTGR 7 5.4 0.97512 -3.185 0 8.5519 0 8.35005 9.0294 8.15015 11.1202 0 0 8.2644 0 9.46567 Q9Y2H0 DLGP4_HUMAN Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) DLGAP4 DAP4 KIAA0964 SAPAP4 Homo sapiens (Human) modification of postsynaptic structure [GO:0099010]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synapse maturation [GO:0090128]; signaling [GO:0023052] cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090] ASDASDKQRQEAR;IRHLVHSVQRLFFTK;LLQAETER;QAERSQPR;SLPDCTPHPNSISIDAGPRQAPK;VGGNGSK 6 7.5 0.97517 -3.3071 12.9743 0 0 9.53856 9.77098 0 11.9263 0 9.52246 9.93257 0 9.74593 Q9Y2H2 SAC2_HUMAN Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) INPP5F KIAA0966 SAC2 MSTP007 MSTP047 Homo sapiens (Human) adult locomotory behavior [GO:0008344]; cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037] inositol monophosphate 4-phosphatase activity [GO:0052833]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein homodimerization activity [GO:0042803] ELFQAKDHYILQQGER;IIPSPDDSKFLLK;MFIQCQTR;MFIQCQTRIIQI;VVMEQQLK 5 4.3 0.98096 -1.7379 0 0 0 0 8.49566 0 8.26814 0 8.33628 0 12.3833 0 Q9Y2H5 PKHA6_HUMAN Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) PLEKHA6 KIAA0969 PEPP3 Homo sapiens (Human) AEHAGVR;GEGDGRGCEK;HKKDSLQNQLINIR;HQSGSMR;LRKMELEPQHYDVDINK;LVQQLRAEK 6 6.1 0.97551 -3.4075 3.65489 7.22738 0 0 0 8.01542 0 0 8.66099 10.5803 0 0 Q9Y2H6 FND3A_HUMAN Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) FNDC3A FNDC3 HUGO KIAA0970 Homo sapiens (Human) cell-cell adhesion [GO:0098609]; fertilization [GO:0009566]; Sertoli cell development [GO:0060009]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; vesicle membrane [GO:0012506] RNA binding [GO:0003723] IANRTKNSLTLQWK;IKSGKGK;LNESTSYK;VQAEYNSIK 4 3.2 0.97578 -2.3066 10.5864 0 0 0 8.83476 0 9.4871 0 10.0796 0 0 9.18095 Q9Y2H8 ZN510_HUMAN Zinc finger protein 510 ZNF510 KIAA0972 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HLHLNQCGKSFEK 1 1.9 0.91656 -0.42676 9.80433 0 0 0 0 0 0 0 0 0 0 0 Q9Y2H9 MAST1_HUMAN Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) MAST1 KIAA0973 SAST Homo sapiens (Human) brain development [GO:0007420]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ATTPGGRTLER;DVGCTRHQSVQTEDGTGGMARAVAK;INKQNLILR;TPVAAAGSSKREPSTK;YGFTLRAIR 5 4.5 0.96773 -1.3206 0 0 12.0283 0 9.12221 0 0 0 0 9.43544 0 0 Q9Y2I1 NISCH_HUMAN Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; outer dynein arm assembly [GO:0036158]; Rac protein signal transduction [GO:0016601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091] DRYRLDDGR;EEGQGEQGEEEDEEEEEEEDVAENR;EPPQRDR;KGGEDSR;LSSLEGLHTK;VLAQFGER 6 4.3 0.97428 -3.6273 4.64189 0 8.9107 0 0 0 11.8034 0 0 0 0 5.04221 Q9Y2I2 NTNG1_HUMAN Netrin-G1 (Laminet-1) NTNG1 KIAA0976 LMNT1 UNQ571/PRO1133 Homo sapiens (Human) axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; synaptic membrane adhesion [GO:0099560] extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552] cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632] DRFAFFAGPR 1 1.9 0.9204 -0.44387 0 0 0 0 0 0 0 0 0 0 0 7.1914 Q9Y2I6 NINL_HUMAN Ninein-like protein NINL KIAA0980 NLP Homo sapiens (Human) microtubule anchoring at centrosome [GO:0034454] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874] calcium ion binding [GO:0005509] DLEFVLK;IAPAALSV;LDAQREEHEKQLK;LLSLQGEQAR;LQKDLEFVLK;SQEVIWGLQEQLQDTAR 6 4.2 0.97322 -2.9665 13.4486 13.5639 13.1462 11.2702 8.36505 11.0583 9.19542 0 0 11.5058 10.8065 0 Q9Y2I7 FYV1_HUMAN 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) PIKFYVE KIAA0981 PIP5K3 Homo sapiens (Human) "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process [GO:1903100]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; melanosome organization [GO:0032438]; myelin assembly [GO:0032288]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; protein localization to nucleus [GO:0034504]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagosome assembly [GO:2000785]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; retrograde transport, endosome to Golgi [GO:0042147]" cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; vesicle membrane [GO:0012506] "1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion binding [GO:0008270]" ECYDCSEK;FYGHQYTRR;ISAMDASPRNISPGLQNGEKEDR;KMSSCIK;LCGQIFCSRCCNQEIPGK;LQDLFQQEK;LVSVQEDAGK;SQIRAFR;TFTWDKK 9 4.7 0.97573 -5.063 0 0 7.56963 9.35156 0 0 0 12.0797 5.32193 10.6824 10.6414 11.2503 Q9Y2I9 TBC30_HUMAN TBC1 domain family member 30 TBC1D30 KIAA0984 Homo sapiens (Human) negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547] ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] ALSVDMAVFR;DTWDGDEDTEPGEACGGR;VLLAYARWNK;VLQELQERPSQR 4 5.4 0.9809 -1.7607 0 0 0 0 0 0 0 0 6.01977 13.0805 0 0 Q9Y2J0 RP3A_HUMAN Rabphilin-3A (Exophilin-1) RPH3A KIAA0985 Homo sapiens (Human) calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle priming [GO:0016082] cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of membrane [GO:0019898]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphate ion binding [GO:0042301]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; selenium binding [GO:0008430]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]" ISVCDEDK;LENMRKNVAGDGVNR;MSSSSRDSESWDHSGGAGDSSR;SGAWFFKGFPK;SLDISVWDYDIGK;SNDYIGGCQLGISAK 6 12.1 0.94488 -0.64633 0 8.73559 6.0442 0 4.97228 6.70529 0 11.2779 0 0 0 0 Q9Y2J2 E41L3_HUMAN "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" EPB41L3 DAL1 KIAA0987 Homo sapiens (Human) actomyosin structure organization [GO:0031032]; apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] actin binding [GO:0003779]; cytoskeletal protein-membrane anchor activity [GO:0106006]; structural constituent of cytoskeleton [GO:0005200] EQEFAARAAK;EVTDKEQEFAARAAK;GKEGSALTEGAK;SMQCKVILLDGSEYTCDVEK;YTMSRSLDGASVNENHEIYMK;YYLCLQLRDDIVSGR 6 9.6 0.97537 -4.2354 0 0 12.7902 0 6.8515 9.43908 10.1763 12.2181 0 0 3.82038 0 Q9Y2J4 AMOL2_HUMAN Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) AMOTL2 KIAA0989 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; endothelial cell morphogenesis [GO:0001886]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein localization [GO:1903829]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102]; recycling endosome [GO:0055037] actin filament binding [GO:0051015] DAVIKVLQQR;KASGGTPCTLR;LLQLSLER;MTGRKASGGTPCTLR;QDEALRELRHGHVR;VLHAQILEKDAVIK;VLHAQILEKDAVIKVLQQR 7 6.7 0.96617 -1.284 3.76182 11.0006 0 0 0 5.72631 0 0 0 7.7366 0 0 Q9Y2J8 PADI2_HUMAN Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) PADI2 KIAA0994 PAD2 PDI2 Homo sapiens (Human) cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; estrogen receptor signaling pathway [GO:0030520]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of lymphocyte chemotaxis [GO:1901624]; substantia nigra development [GO:0021762]; transcription initiation-coupled chromatin remodeling [GO:0045815] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H1R54 arginine deiminase activity [GO:0140810]; histone H2AR3 arginine deiminase activity [GO:0140811]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; histone H4R3 arginine deiminase activity [GO:0140809]; nuclear estrogen receptor binding [GO:0030331]; protein homodimerization activity [GO:0042803]; protein-arginine deiminase activity [GO:0004668] GLGGMSSKRITINK;VGVFYVENPFFGQR 2 4.2 0.84741 -0.071959 0 7.96688 6.71136 0 0 0 0 0 0 0 0 0 Q9Y2K1 ZBTB1_HUMAN Zinc finger and BTB domain-containing protein 1 ZBTB1 KIAA0997 Homo sapiens (Human) B cell differentiation [GO:0030183]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of pro-T cell differentiation [GO:2000176]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell mediated immunity [GO:0002711]; protein homooligomerization [GO:0051260]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; translesion synthesis [GO:0019985] nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HLYQNTR;IVDIRDGK;LLDEHVLTCTNR;SFTCDSCGFGFSCEK 4 5.9 0.9549 -0.81626 0 0 0 5.88118 9.04772 9.17078 0 0 0 0 0 0 Q9Y2K2 SIK3_HUMAN Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) SIK3 KIAA0999 QSK L19 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau-protein kinase activity [GO:0050321] DLKAENLLLDANLNIK;LIAECQQLKEER;TQLDEENLK;TQLDEENLKK 4 2.9 0.96396 -1.1835 0 0 11.0888 8.35557 0 0 0 12.8144 0 0 10.5223 0 Q9Y2K3 MYH15_HUMAN Myosin-15 (Myosin heavy chain 15) MYH15 KIAA1000 Homo sapiens (Human) extraocular skeletal muscle development [GO:0002074] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] ALADWKQK;ELQTQIKDLK;HEESQALLDASQKEVQALSTELLKLK;LCTLYEER;LEAERTTR;LEAERTTRAK;LTGAIMHFGNMKFK;LWSESGEFLR;MKYENNVIQR;QQHELNEVKER;SAEAQRGAR;TLSKVNAEMVQWRMK;VEQMTRAK;WLVARINRALDAK 14 7.8 0.97865 -9.8996 0 12.5297 6.24738 0 11.4977 0 0 11.6881 9.02475 7.45886 11.3131 0 Q9Y2K6 UBP20_HUMAN Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) USP20 KIAA1003 LSFR3A VDU2 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; nervous system development [GO:0007399]; positive regulation of autophagy [GO:0010508]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; zinc ion binding [GO:0008270] IAQVKGSGHVQLK;LVNPMFRGYAQQDTQEFLR;YCKVLRLPEILCIHLK 3 5.3 0.9807 -1.6207 0 0 0 7.90713 0 0 0 10.2207 0 0 0 10.6961 Q9Y2K7 KDM2A_HUMAN Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) KDM2A CXXC8 FBL11 FBL7 FBXL11 JHDM1A KIAA1004 Homo sapiens (Human) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of transcription by competitive promoter binding [GO:0010944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleoplasm [GO:0005654] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] FGGPGRMK;FGGPGRMKQSCVLR;IANVTLIDLR;IDLSRCK;QITRKACEHFISDLSINSLYCLSDEK 5 4.9 0.98133 -1.6996 5.85434 0 7.60237 0 0 0 3.68997 0 11.2223 0 0 0 Q9Y2K9 STB5L_HUMAN Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) STXBP5L KIAA1006 LLGL4 Homo sapiens (Human) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905] GAAGGVMGELTRAR;SSDLYQRQPR;SSSISSIDK;SSSISSIDKDSK 4 3 0.97602 -5.2994 0 0 0 9.09122 0 0 0 10.142 0 11.2346 0 0 Q9Y2L1 RRP44_HUMAN Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) DIS3 KIAA1008 RRP44 Homo sapiens (Human) "CUT catabolic process [GO:0071034]; nuclear mRNA surveillance of mRNA 3'-end processing [GO:0071031]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]" cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; endonuclease activity [GO:0004519]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723] IEDTVFHVFDK;IEKGALTLSSPEVR;IVREHYLR;LAFSCIWEMNHNAEILK;QASTLEGR 5 6.1 0.97914 -1.988 0 0 0 10.6349 0 0 0 0 0 9.94886 10.1854 0 Q9Y2L5 TPPC8_HUMAN Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) TRAPPC8 KIAA1012 Homo sapiens (Human) collagen biosynthetic process [GO:0032964]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] DICKNMVLAER;DPNNQLHVIKNLK;EKGKFCFK;LASREKGK;QDLEIQGPRLNNTK;SLFSATK 6 4 0.96736 -1.3182 0 3.26703 0 7.53652 0 8.90198 0 0 12.0405 0 6.22618 0 Q9Y2L6 FRM4B_HUMAN FERM domain-containing protein 4B (GRP1-binding protein GRSP1) FRMD4B GRSP1 KIAA1013 Homo sapiens (Human) establishment of epithelial cell polarity [GO:0090162] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; ruffle [GO:0001726] ELLDLVASHFNLK;GDYTSDENAR;GQAVVQYMKIVEALPTYGVHYYAVK;LFQWKQLENLYFR;LVTLETK;QRDYSRSFHEDEVDR 6 8 0.95489 -0.88354 0 0 0 0 0 0 8.03881 9.59787 12.7699 0 0 0 Q9Y2L9 LRCH1_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) LRCH1 CHDC1 KIAA1016 Homo sapiens (Human) cellular response to chemokine [GO:1990869]; negative regulation of GTPase activity [GO:0034260]; negative regulation of T cell migration [GO:2000405] cytoplasm [GO:0005737] ADGLHSEFMNYKAR;LGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLR;LGVPEEK;LSMAKCR 4 9.5 0.97571 -3.4316 11.0885 0 0 0 0 0 0 6.66135 8.22574 0 0 0 Q9Y2M0 FAN1_HUMAN Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) FAN1 KIAA1018 MTMR15 Homo sapiens (Human) DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; magnesium ion binding [GO:0000287]; phosphodiesterase I activity [GO:0004528]; ubiquitin-modified protein reader activity [GO:0140036] ATRECEK;LEPTIKCITEGLADPEVR;LHMYEEAVRELESLLSQR;LVEVKGPNDR 4 5.2 0.97478 -3.1144 0 0 8.65037 0 6.52917 0 10.0462 0 0 10.9466 10.7693 11.1794 Q9Y2M2 SSUH2_HUMAN Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) odontogenesis [GO:0042476] cytoplasm [GO:0005737]; nucleus [GO:0005634] heat shock protein binding [GO:0031072]; unfolded protein binding [GO:0051082] CQLCAGSGRRR;CSGCHGAGTVRCPSCCGAK;CSTCSGR;RQTLCRYR 4 12 0.91293 -0.38816 0 0 0 0 0 0 8.41967 0 0 8.52015 9.09297 4.44778 Q9Y2M5 KLH20_HUMAN Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X) KLHL20 KLEIP KLHLX Homo sapiens (Human) cytoskeleton organization [GO:0007010]; Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; response to interferon-alpha [GO:0035455] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802] actin binding [GO:0003779]; type II interferon binding [GO:0019964]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] DLVDEAK;FLVGTVGSDPLIKSDEECR;MVASMSK 3 5.4 0.9637 -1.1116 0 0 0 0 0 0 9.68366 0 0 0 0 0 Q9Y2N7 HIF3A_HUMAN Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7) HIF3A BHLHE17 MOP7 PASD7 Homo sapiens (Human) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AGSAQAD;LSCSSPSR 2 2.2 0.9172 -0.3993 0 0 0 0 7.19426 0 0 0 0 8.84072 7.01581 0 Q9Y2P4 S27A6_HUMAN "Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (EC 6.2.1.-)" SLC27A6 ACSVL2 FACVL2 FATP6 Homo sapiens (Human) long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; very long-chain fatty acid metabolic process [GO:0000038] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; very long-chain fatty acid-CoA ligase activity [GO:0031957] QSKREGEK;VVLIIIR;VVLIIIRLKK 3 2.9 0.97782 -1.5132 0 0 0 0 0 0 0 0 0 4.38585 2.93399 0 Q9Y2P5 S27A5_HUMAN "Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)" SLC27A5 ACSB ACSVL6 FACVL3 FATP5 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; establishment of localization in cell [GO:0051649]; ketone body biosynthetic process [GO:0046951]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; triglyceride mobilization [GO:0006642]; very long-chain fatty acid metabolic process [GO:0000038] basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oxidoreductase activity [GO:0016491]; protein-containing complex binding [GO:0044877]; very long-chain fatty acid-CoA ligase activity [GO:0031957] WLPADVIFLAKILHLGLKIR 1 2.9 0.46524 0.19077 0 0 0 0 0 0 0 0 0 0 0 9.01243 Q9Y2P8 RCL1_HUMAN RNA 3'-terminal phosphate cyclase-like protein RCL1 RNAC RPC2 RPCL1 RTC2 HSPC338 Homo sapiens (Human) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA endonuclease activity [GO:0004521] LVLSTLSGRPVK 1 3.2 0.88825 -0.20197 0 0 9.6755 9.28568 0 0 0 9.41481 0 0 0 9.9884 Q9Y2Q0 AT8A1_HUMAN Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATP8A1 ATPIA Homo sapiens (Human) aminophospholipid translocation [GO:0140331]; learning [GO:0007612]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092]; synaptic vesicle endocytosis [GO:0048488]; transport across blood-brain barrier [GO:0150104] azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; magnesium ion binding [GO:0000287]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] VSKCILYCFYK;YALTFGVRQYFLDLALSCK 2 2.6 0.95824 -1.0126 0 0 0 0 0 0 0 0 0 0 8.91528 0 Q9Y2Q1 ZN257_HUMAN Zinc finger protein 257 (Bone marrow zinc finger 4) (BMZF-4) ZNF257 BMZF4 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFNRSSHLTQHK;VFYKFSNSDR 2 6 0.9741 -3.0283 0 0 0 0 0 0 14.28 0 0 0 0 0 Q9Y2Q3 GSTK1_HUMAN Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) GSTK1 HDCMD47P Homo sapiens (Human) epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364] NEDITEPQSILAAAEK;VKNQLKETTEAACR 2 13.3 0.8767 -0.12597 11.7601 0 0 0 0 0 0 0 0 8.92638 9.22718 0 Q9Y2R0 COA3_HUMAN "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (Coiled-coil domain-containing protein 56) (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa)" COA3 CCDC56 MITRAC12 HSPC009 Homo sapiens (Human) mitochondrial cytochrome c oxidase assembly [GO:0033617]; positive regulation of mitochondrial translation [GO:0070131] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] IDPTREK 1 6.6 0.96438 -1.1739 0 0 0 0 0 0 9.81895 9.66991 9.38769 0 0 0 Q9Y2R2 PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) PTPN22 PTPN8 Homo sapiens (Human) autophagy [GO:0006914]; cellular response to muramyl dipeptide [GO:0071225]; lipid metabolic process [GO:0006629]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; protein dephosphorylation [GO:0006470]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of innate immune response [GO:0045088]; regulation of natural killer cell proliferation [GO:0032817]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to lipopolysaccharide [GO:0032496]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "histone H2AXY142 phosphatase activity [GO:0140793]; kinase binding [GO:0019900]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]" FNSETRTIYQFHYK;MDQREILQK;TGVICAIDYTWMLLK;TIYQFHYK 4 4.7 0.96489 -1.1514 0 12.2685 10.5946 0 9.71053 0 0 0 11.9241 0 0 0 Q9Y2R4 DDX52_HUMAN Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52) DDX52 ROK1 HUSSY-19 Homo sapiens (Human) maturation of SSU-rRNA [GO:0030490] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FSADAAR;LFEDGKTGFR;VTGQNSK 3 4 0.97483 -2.3974 8.66619 11.7757 0 0 0 0 0 0 0 0 0 10.7634 Q9Y2R5 RT17_HUMAN "Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt)" MRPS17 RPMS17 HSPC011 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] WIVGKVIGTKMQK 1 10 0.86957 -0.094065 0 7.12298 0 0 0 0 0 6.84712 0 0 0 0 Q9Y2R9 RT07_HUMAN "Small ribosomal subunit protein uS7m (28S ribosomal protein S7, mitochondrial) (MRP-S7) (S7mt) (bMRP-27a) (bMRP27a)" MRPS7 Homo sapiens (Human) mitochondrial translation [GO:0032543]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; ribosome [GO:0005840] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] DPLIDKEYYR;GWSGLALGVR;RFLAMKWMITECR;YSPEFKDPLIDKEYYR 4 16.1 0.97206 -2.7938 0 0 12.6216 6.13219 10.223 0 0 0 0 11.8045 0 10.3967 Q9Y2S2 CRYL1_HUMAN Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 CRY Homo sapiens (Human) D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829]; extracellular exosome [GO:0070062] L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803] IFAQLDSIIDDR;LFAGLVHVK;SWAMLFASGGFQVK 3 11 0.94139 -0.61166 12.2436 0 0 0 0 0 0 0 10.7773 0 0 0 Q9Y2S7 PDIP2_HUMAN Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38) POLDIP2 PDIP38 POLD4 HSPC017 Homo sapiens (Human) error-free translesion synthesis [GO:0070987]; mitochondrion organization [GO:0007005]; mitotic spindle assembly [GO:0090307]; negative regulation of macroautophagy [GO:0016242]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cytokinesis [GO:1903490]; vascular associated smooth muscle cell proliferation [GO:1990874] cell-cell junction [GO:0005911]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] DNA binding [GO:0003677] GVVLFPWQARLYDR;LENLDSDVVQLRERHWR;LYDRDVASAAPEK 3 10.9 0.95447 -0.91197 0 0 11.1316 0 0 9.50237 0 9.08783 0 0 0 0 Q9Y2T1 AXIN2_HUMAN Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2 Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cellular response to dexamethasone stimulus [GO:0071549]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; dorsal/ventral axis specification [GO:0009950]; intramembranous ossification [GO:0001957]; maintenance of DNA repeat elements [GO:0043570]; mitral valve morphogenesis [GO:0003183]; mRNA stabilization [GO:0048255]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization [GO:0008104]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of chondrocyte development [GO:0061181]; regulation of extracellular matrix organization [GO:1903053]; regulation of mismatch repair [GO:0032423]; secondary heart field specification [GO:0003139]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089] beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625] KGNYRYYFK;LKLELESR;LSPTVVGLSSKTLR 3 3.7 0.97825 -2.0672 0 12.5592 0 0 0 0 0 0 0 0 0 12.824 Q9Y2T2 AP3M1_HUMAN AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) AP3M1 Homo sapiens (Human) "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynaptic recycling endosome [GO:0098837] small GTPase binding [GO:0031267] HSISFKENSSCGR;VLTWDVGK 2 5 0.95471 -0.95728 0 0 3.2671 0 0 0 0 0 0 0 0 0 Q9Y2T3 GUAD_HUMAN Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) GDA KIAA1258 Homo sapiens (Human) allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; deoxyguanosine catabolic process [GO:0006161]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; guanine metabolic process [GO:0046098]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139] cytosol [GO:0005829] guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270] CAAQMPPLAHIFR;FVSEMLQK;NIEEVYVGGK 3 6.8 0.89746 -0.24665 0 0 0 0 0 0 0 0 11.4213 0 10.2306 0 Q9Y2U5 M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) MAP3K2 MAPKKK2 MEKK2 Homo sapiens (Human) cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] IATQPTNPK;IVQYYGCLRDPQEK 2 3.7 0.9571 -1.0266 0 0 0 0 7.07178 0 0 0 0 0 0 0 Q9Y2U8 MAN1_HUMAN Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) LEMD3 MAN1 Homo sapiens (Human) negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965] DNA binding [GO:0003677]; U1 snRNP binding [GO:1990446] SGGRGNK 1 0.8 0.74087 0.10658 0 0 0 0 0 0 0 0 11.8645 0 0 0 Q9Y2V2 CHSP1_HUMAN Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) CARHSP1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488] cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186]; P-body [GO:0000932] mRNA 3'-UTR binding [GO:0003730]; phosphatase binding [GO:0019902] SSEPPPPPQPPTHQASVGLLDTPR 1 16.3 0 2.9427 0 0 0 0 0 0 0 0 0 0 8.63695 0 Q9Y2V3 RX_HUMAN Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein) RAX RX Homo sapiens (Human) camera-type eye development [GO:0043010]; hypothalamus development [GO:0021854]; limb development [GO:0060173]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LEVSSMK;LSEEEQPKK 2 4.6 0.90621 -0.27249 0 0 0 0 0 0 10.2825 0 8.86938 0 0 0 Q9Y2V7 COG6_HUMAN Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 KIAA1134 Homo sapiens (Human) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] AAMVQFDR;AQVADAFLSK;EVLASHDSSVVPLDAR 3 5.2 0.95548 -0.8093 11.7648 0 10.6709 9.71227 0 0 0 9.30424 0 0 0 10.7469 Q9Y2W1 TR150_HUMAN Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) THRAP3 BCLAF2 TRAP150 Homo sapiens (Human) "circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ASAVSELSPR;EAQVNVR;ESEFDDEPK;LGTKDFVGPSER;NREEEWDPEYTPKSK;RRSPSPR;SIFQHIQSAQSQR;SPLQSVVVR;SPREPGYK;TEELEEESFPERSK;YKDDPVDLR;YLKRGTEQEAAK 12 13.1 0.97697 -5.6323 7.87633 9.91864 0 11.2011 11.1171 9.99788 12.4222 0 0 11.1075 8.9782 10.3277 Q9Y2W2 WBP11_HUMAN WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) WBP11 NPWBP SIPP1 SNP70 Homo sapiens (Human) mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699] AAVLKMKDPK;AVSILPLLGHGVPR;FVPTALR;LEVEYEQKR;LYEKENPDIYK;TSAYGPPTR;VGFALDLPPRRR 7 11.2 0.97536 -4.2271 12.3422 11.9216 11.675 8.13955 0 0 10.6452 0 0 10.8078 0 0 Q9Y2W3 S45A1_HUMAN Proton-associated sugar transporter A (PAST-A) (Deleted in neuroblastoma 5 protein) (DNb-5) (Solute carrier family 45 member 1) SLC45A1 DNB5 Homo sapiens (Human) D-glucose transmembrane transport [GO:1904659]; galactose transmembrane transport [GO:0015757] membrane [GO:0016020] D-glucose:proton symporter activity [GO:0005356]; galactose:proton symporter activity [GO:0015517]; sucrose:proton symporter activity [GO:0008506] RRPFILVLAIGALLGLSLLLNGR 1 3.1 0.34483 0.23712 0 4.19133 0 0 0 0 0 0 0 0 0 0 Q9Y2W6 TDRKH_HUMAN Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) fertilization [GO:0009566]; male meiotic nuclear division [GO:0007140]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283] mitochondrion [GO:0005739]; P granule [GO:0043186]; pi-body [GO:0071546]; piP-body [GO:0071547] RNA binding [GO:0003723] AVPDMLKDMATETDASLSTLLTETKK;ISSYVQTGISTWPK;STERTSWTSLSTIQKIALGLGIPASATVAYILYR 3 13.2 0.9726 -2.6776 8.18225 7.96625 11.8715 8.71682 8.60403 8.18844 0 0 0 0 0 0 Q9Y2X0 MED16_HUMAN Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92) MED16 DRIP92 THRAP5 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713] LLTKLWICCR;WSKSTHCPSVPLACAWSCR 2 3.3 0.97732 -2.2277 0 12.4456 12.2846 10.5224 0 0 0 0 0 0 0 0 Q9Y2X3 NOP58_HUMAN Nucleolar protein 58 (Nucleolar protein 5) NOP58 NOL5 NOP5 HSPC120 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254] box C/D methylation guide snoRNP complex [GO:0031428]; Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] ATPase binding [GO:0051117]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; TFIID-class transcription factor complex binding [GO:0001094] ELNNYIMR;LQEVDSLWKEFETPEK;SQMDGLIPGVEPR 3 7 0.20902 0.32469 0 0 0 0 9.84111 0 0 0 10.0128 0 6.94228 0 Q9Y2X7 GIT1_HUMAN ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GIT1 Homo sapiens (Human) brain development [GO:0007420]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; intramembranous ossification [GO:0001957]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-1 beta production [GO:0032691]; neuron development [GO:0048666]; positive regulation of microtubule nucleation [GO:0090063]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cytokinesis [GO:0032465]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202] gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] LFEELAMDVYDEVDR 1 2 0.78356 0.026263 0 0 0 7.85748 0 0 0 0 0 0 0 0 Q9Y2X9 ZN281_HUMAN Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) ZNF281 GZP1 ZBP99 Homo sapiens (Human) embryonic body morphogenesis [GO:0010172]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" IHSREKPFGCDQCSMK;NLESSTGFQIPSQELASQIDPQK;RPKPESQGIK;SIAIENKEQK 4 6.6 0.97831 -2.1243 13.6659 0 0 0 0 0 0 0 9.64415 0 11.8818 0 Q9Y2Y1 RPC10_HUMAN DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) POLR3K RPC11 My010 Homo sapiens (Human) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] CCNAQCGHR 1 8.3 0.6772 0.16571 0 7.00416 0 0 0 0 0 0 0 0 0 0 Q9Y2Y6 TMM98_HUMAN Transmembrane protein 98 (Protein TADA1) TMEM98 UNQ536/PRO1079 Homo sapiens (Human) negative regulation of myelination [GO:0031642]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein processing [GO:0010955]; T-helper 1 cell differentiation [GO:0045063] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] ETVVIVAIGVLATIFLASFAALVLVCR;MKTSASVSDIIVVAKR 2 19 0.76529 0.06484 0 0 0 0 0 0 7.05344 6.18444 0 0 0 0 Q9Y2Z0 SGT1_HUMAN Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) SUGT1 Homo sapiens (Human) kinetochore assembly [GO:0051382]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle organization [GO:0007051] cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] lncRNA binding [GO:0106222]; protein-folding chaperone binding [GO:0051087] AAAAAGTATSQR;LPSGEDYNLK;LVGEIKEEEK;VLSTKIEIKLK 4 11.8 0 34.887 0 10.7995 9.47326 3.31034 2.71875 0 0 0 8.95609 10.2891 0 0 Q9Y2Z2 MTO1_HUMAN "Protein MTO1 homolog, mitochondrial" MTO1 CGI-02 Homo sapiens (Human) mitochondrial tRNA wobble uridine modification [GO:0070899]; tRNA methylation [GO:0030488] cytosol [GO:0005829]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660]; RNA binding [GO:0003723] AVPEPLK;GCGRWVAVSFTK;GLEKAKVIQPDGVLLLLPR;LSSDSAAPR;LTLRGYKDAGCVSQQR;VDEIVLK;VLRFPNR 7 10.7 0.97523 -4.2088 0 8.94629 6.65707 0 7.64436 9.16624 0 12.9731 0 0 0 7.32921 Q9Y2Z4 SYYM_HUMAN "Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" YARS2 CGI-04 Homo sapiens (Human) mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; translation [GO:0006412]; tRNA aminoacylation [GO:0043039] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] ATP binding [GO:0005524]; L-tyrosine binding [GO:0072545]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831] DFFPETGTKIELPELFDR;DKTSPFELYQFFVR;IELPELFDR;IGKRNFYIIK;LGDPSGR;LVHGREGLDSAK 6 12.8 0.97438 -3.7734 0 0 9.42253 0 0 0 8.28882 0 12.8583 0 11.0393 0 Q9Y2Z9 COQ6_HUMAN "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)" COQ6 CGI-10 Homo sapiens (Human) ubiquinone biosynthetic process [GO:0006744] cell projection [GO:0042995]; extrinsic component of mitochondrial inner membrane [GO:0031314]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142] "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity [GO:0106364]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" ILLLEAGPK 1 1.9 0.03964 0.51862 18.092 0 13.2039 0 15.2195 15.0139 9.49999 10.4502 0 0 0 0 Q9Y2Z9 COQ6_HUMAN "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)" COQ6 CGI-10 Homo sapiens (Human) ubiquinone biosynthetic process [GO:0006744] cell projection [GO:0042995]; extrinsic component of mitochondrial inner membrane [GO:0031314]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142] "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity [GO:0106364]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" MIFTFMTRKSCCSK 1 3.6 0.86572 -0.088319 0 0 0 0 0 0 0 0 0 5.78686 0 0 Q9Y303 NAGA_HUMAN N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2) AMDHD2 CGI-14 Homo sapiens (Human) N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; negative regulation of UDP-N-acetylglucosamine biosynthetic process [GO:0106279]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448] ILSHGVTSFCPTLVTSPPEVYHK;TATVGSDVR 2 5.4 0.91845 -0.40583 8.07505 0 0 0 0 0 0 0 0 0 0 0 Q9Y305 ACOT9_HUMAN "Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)" ACOT9 CGI-16 Homo sapiens (Human) acyl-CoA metabolic process [GO:0006637] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetyl-CoA hydrolase activity [GO:0003986]; carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816] GLTQGPQNPK;YLTVQNTVRFGR 2 5 0.95176 -0.68369 0 0 0 0 0 0 7.13853 11.8552 0 0 0 0 Q9Y314 NOSIP_HUMAN Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) NOSIP CGI-25 Homo sapiens (Human) negative regulation of catalytic activity [GO:0043086]; negative regulation of nitric-oxide synthase activity [GO:0051001]; regulation of nitric oxide biosynthetic process [GO:0045428] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular sequestering activity [GO:0140313]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] EEQKELQRAASQDHVR 1 5.3 0.85029 -0.076074 0 0 0 0 0 0 0 0 0 0 0 10.3952 Q9Y316 MEMO1_HUMAN Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) MEMO1 C2orf4 MEMO NS5ATP7 CGI-27 Homo sapiens (Human) regulation of microtubule-based process [GO:0032886] cytosol [GO:0005829]; nucleus [GO:0005634] QVDPSITRRIFILGPSHHVPLSR 1 7.7 0.96364 -1.1076 0 0 0 0 9.39328 0 0 0 0 0 0 0 Q9Y320 TMX2_HUMAN Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) TMX2 TXNDC14 CGI-31 My009 PIG26 PSEC0045 UNQ237/PRO270 Homo sapiens (Human) brain development [GO:0007420] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802] EAMRRPQIDK 1 3.4 0.88685 -0.19144 0 0 0 0 0 0 0 0 0 9.60912 0 0 Q9Y330 ZBT12_HUMAN Zinc finger and BTB domain-containing protein 12 (Protein G10) ZBTB12 C6orf46 G10 NG35 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FAHKPAIRRHLK 1 2.6 0.61303 0.17457 0 0 0 0 0 0 7.52927 0 0 0 0 0 Q9Y333 LSM2_HUMAN U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) LSM2 C6orf28 G7B Homo sapiens (Human) "mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; U6 snRNA binding [GO:0017070] LTDISVTDPEK 1 11.6 0.91537 -0.37145 0 0 12.5812 0 0 0 0 0 0 0 0 0 Q9Y337 KLK5_HUMAN Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme) KLK5 SCTE UNQ570/PRO1132 Homo sapiens (Human) amelogenesis [GO:0097186]; cornification [GO:0070268]; epidermis development [GO:0008544]; extracellular matrix disassembly [GO:0022617]; positive regulation of antibacterial peptide production [GO:0002803]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein maturation [GO:0051604]; proteolysis [GO:0006508] cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] QIDDTMFCAGDKAGR 1 5.1 0.8256 -0.019415 0 0 6.69307 0 0 0 0 0 0 0 0 0 Q9Y343 SNX24_HUMAN Sorting nexin-24 SNX24 SBBI31 UNQ654/PRO1284 Homo sapiens (Human) protein transport [GO:0015031] cytoplasmic vesicle membrane [GO:0030659] phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] AESCGSFDETESEESSK 1 10.1 0.7843 0.020293 0 0 0 0 0 0 0 0 0 5.68698 0 0 Q9Y365 STA10_HUMAN START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) STARD10 SDCCAG28 CGI-52 Homo sapiens (Human) lipid transport [GO:0006869] cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514] lipid binding [GO:0008289] AGVSVWVQAVEMDR;AMKKMYK;AVSIQTGYLIQSTGPK;LTVNADVGYYSWRCPKPLKNR 4 19.9 0.97408 -2.4609 10.2922 11.4064 9.72475 0 9.28297 0 0 0 0 9.75937 0 0 Q9Y371 SHLB1_HUMAN Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1) SH3GLB1 KIAA0491 CGI-61 Homo sapiens (Human) apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; membrane fission [GO:0090148]; membrane organization [GO:0061024]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of membrane tubulation [GO:1903527]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to vacuolar membrane [GO:1903778]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647] autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] AECTKIWTEKIMK;AVQFTEEK;LDLDAAK;LGQAEKTELDAHLENLLSKAECTK 4 12.9 0.96203 -1.0698 0 0 0 0 8.58729 0 0 7.76042 0 0 9.9388 8.84075 Q9Y376 CAB39_HUMAN Calcium-binding protein 39 (MO25alpha) (Protein Mo25) CAB39 MO25 CGI-66 Homo sapiens (Human) cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; response to activity [GO:0014823]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018] kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] NIQFEAFHVFKVFVANPNK;QDISDKKAEK 2 8.5 0.89811 -0.25314 0 0 0 0 0 0 0 11.6582 0 0 0 5.83645 Q9Y383 LC7L2_HUMAN Putative RNA-binding protein Luc7-like 2 LUC7L2 CGI-59 CGI-74 Homo sapiens (Human) mRNA splice site recognition [GO:0006376] nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] AERVHELNEEIGK;SYESANGRSEDR;VIHSQLK;VMDEVEK 4 10 0.98078 -1.7277 10.5005 11.3188 11.6395 0 0 0 0 0 0 0 12.0585 0 Q9Y385 UB2J1_HUMAN Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205 Homo sapiens (Human) "ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; protein polyubiquitination [GO:0000209]; regulation of macrophage cytokine production [GO:0010935]; regulation of tumor necrosis factor production [GO:0032680]; spermatid development [GO:0007286]" endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625] SQDFCCEGCGSAMK 1 4.4 0.69288 0.16217 0 3.71962 0 0 0 0 0 0 0 0 0 0 Q9Y388 RBMX2_HUMAN "RNA-binding motif protein, X-linked 2" RBMX2 CGI-79 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] HEHKSSSRR;TIRVDHVSNYR 2 6.2 0.8881 -0.20227 0 0 3.21776 0 0 0 0 0 0 9.21242 0 10.5721 Q9Y394 DHRS7_HUMAN Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" SLCMDTSLDVYR 1 3.5 0.80867 0.01093 0 0 0 0 0 7.95989 0 0 0 0 0 0 Q9Y399 RT02_HUMAN "Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt)" MRPS2 CGI-91 Homo sapiens (Human) mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] ATSSAALPRILGAGARAPSR;ILNEPLKHSDFFNVKELFSVR 2 13.9 0.81351 -0.011404 7.18963 0 0 0 0 0 0 0 0 0 10.3969 0 Q9Y3A2 UTP11_HUMAN Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein) UTP11 UTP11L CGI-94 HDCMB12P Homo sapiens (Human) nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] EEVTPEQLKLMRTQDVK;ETKEEVTPEQLK;ETKEEVTPEQLKLMR;GVTNQTGLK;HLGLLEKK;HVFFFDTKK;TQKVKVK 7 20.9 0.973 -2.8593 8.34421 10.5124 0 5.5311 8.34283 9.79799 0 10.3021 0 11.4873 0 0 Q9Y3A5 SBDS_HUMAN Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein) SBDS CGI-97 Homo sapiens (Human) bone marrow development [GO:0048539]; bone mineralization [GO:0030282]; cytosolic ribosome assembly [GO:0042256]; hematopoietic progenitor cell differentiation [GO:0002244]; inner cell mass cell proliferation [GO:0001833]; leukocyte chemotaxis [GO:0030595]; mitotic spindle organization [GO:0007052]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] DIHYSVK;SIFTPTNQIR 2 6.8 0.0087146 1.0585 0 0 0 0 0 0 0 0 0 9.91151 0 0 Q9Y3B1 PLD3B_HUMAN PRELI domain containing protein 3B (Protein slowmo homolog 2) PRELID3B C20orf45 SLMO2 CGI-107 Homo sapiens (Human) phospholipid transport [GO:0015914] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] phosphatidic acid transfer activity [GO:1990050] TYVQEHSVVDPVEKTMELK 1 9.8 0.88133 -0.157 0 0 0 0 0 0 0 0 0 0 0 11.4722 Q9Y3B3 TMED7_HUMAN Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) TMED7 CGI-109 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] QYDSFTFTASK;VAYWSVGEALILLVVSIGQVFLLK;VLYKEMKK 3 19.2 0.92128 -0.44155 0 8.87639 0 0 0 0 11.1406 0 0 0 7.84887 0 Q9Y3B4 SF3B6_HUMAN "Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)" SF3B6 SAP14 SF3B14 SF3B14A CGI-110 HSPC175 HT006 Homo sapiens (Human) "blastocyst formation [GO:0001825]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EKYGINTDPPK;VGNTPETR;YLVVLYYNANR 3 24 0.96531 -1.1352 0 0 0 0 0 9.38234 0 0 0 8.55987 0 0 Q9Y3B6 EMC9_HUMAN ER membrane protein complex subunit 9 (Protein FAM158A) EMC9 C14orf122 FAM158A CGI-112 Homo sapiens (Human) protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789] VPPVIVLENQGLRWVPK 1 8.2 0.92161 -0.4392 0 0 0 0 0 0 0 6.55559 0 0 0 0 Q9Y3B7 RM11_HUMAN "Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11)" MRPL11 CGI-113 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DLSSEELAAFQKERAIFLAAQK 1 11.5 0.95508 -0.96358 0 0 0 0 0 0 0 0 0 11.1348 0 0 Q9Y3B8 ORN_HUMAN "Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)" REXO2 SFN SMFN CGI-114 Homo sapiens (Human) nucleobase-containing compound metabolic process [GO:0006139]; nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676] FLDKYMPQFMK 1 4.6 0.95345 -0.67608 0 0 0 0 0 0 0 0 0 0 0 10.4127 Q9Y3B9 RRP15_HUMAN RRP15-like protein (Ribosomal RNA-processing protein 15) RRP15 KIAA0507 CGI-115 Homo sapiens (Human) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "preribosome, large subunit precursor [GO:0030687]" DFISVLRGMDGSTNETASSRK;GVVQLFNAVQKHQKNVDEK 2 14.2 0.95426 -0.90428 0 0 0 0 0 0 0 0 0 9.52372 0 10.2286 Q9Y3C0 WASC3_HUMAN WASH complex subunit 3 (Coiled-coil domain-containing protein 53) WASHC3 AD-016 CCDC53 CGI-116 x0009 Homo sapiens (Human) actin filament polymerization [GO:0030041]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315] early endosome membrane [GO:0031901]; WASH complex [GO:0071203] TVEESSDSESSFSD 1 7.2 0.79966 0.014577 5.19428 0 0 0 0 0 0 0 0 7.81429 0 0 Q9Y3C1 NOP16_HUMAN Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3) NOP16 CGI-117 HSPC111 Homo sapiens (Human) ribosomal large subunit biogenesis [GO:0042273] intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] DEKNYYQDTPK;LNRNARR 2 10.1 0.97982 -1.8403 0 0 11.417 0 0 0 0 0 0 9.39568 0 0 Q9Y3C5 RNF11_HUMAN RING finger protein 11 RNF11 CGI-123 Homo sapiens (Human) protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511] early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; ubiquitin ligase complex [GO:0000151] DNA binding [GO:0003677]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GVYDPGR;GVYDPGRDGSEK 2 7.8 0.93302 -0.50738 0 0 0 0 0 0 7.89233 8.48446 0 0 0 0 Q9Y3C8 UFC1_HUMAN Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) UFC1 CGI-126 HSPC155 Homo sapiens (Human) brain development [GO:0007420]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of type II interferon production [GO:0032649]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] extracellular exosome [GO:0070062] UFM1 conjugating enzyme activity [GO:0061657]; UFM1 transferase activity [GO:0071568] EEYQSLIRYVENNK 1 8.4 0.91919 -0.43799 0 0 0 0 0 0 0 9.19071 0 0 0 0 Q9Y3D3 RT16_HUMAN "Small ribosomal subunit protein bS16m (28S ribosomal protein S16, mitochondrial) (MRP-S16) (S16mt)" MRPS16 RPMS16 CGI-132 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] IVAAHNKCPRDGR 1 9.5 0.86399 -0.087792 9.76676 0 0 0 0 0 0 0 0 0 0 0 Q9Y3D6 FIS1_HUMAN Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) FIS1 TTC11 CGI-135 Homo sapiens (Human) apoptotic process [GO:0006915]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of fatty acid transport [GO:2000192]; peroxisome fission [GO:0016559]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein targeting to mitochondrion [GO:0006626] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular adaptor activity [GO:0060090] AAGSVSK;GIVLLEELLPKGSK 2 13.8 0.84035 -0.046211 0 0 0 9.25578 0 0 0 0 8.06059 0 0 0 Q9Y3D8 KAD6_HUMAN Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase) AK6 CINAP AD-004 CGI-137 Homo sapiens (Human) nucleobase-containing small molecule interconversion [GO:0015949]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] Cajal body [GO:0015030]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; nucleoside monophosphate kinase activity [GO:0050145] TDTNVLYERLETR 1 7.6 0.8825 -0.17998 0 0 0 0 0 0 0 0 0 6.81852 0 0 Q9Y3D9 RT23_HUMAN "Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial) (MRP-S23) (S23mt)" MRPS23 CGI-138 HSPC329 Homo sapiens (Human) mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EPVFQRPRVR 1 5.3 0.88848 -0.18435 0 0 0 0 0 0 0 0 0 0 9.01475 0 Q9Y3E5 PTH2_HUMAN "Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1)" PTRH2 BIT1 PTH2 CGI-147 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of anoikis [GO:2000811]; negative regulation of gene expression [GO:0010629]; positive regulation of anoikis [GO:2000210] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] aminoacyl-tRNA hydrolase activity [GO:0004045] QIQRRNPEMLK 1 6.1 0.86485 -0.089515 0 0 0 0 0 0 0 0 0 6.81686 0 0 Q9Y3E7 CHMP3_HUMAN Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24) CHMP3 CGI149 NEDF VPS24 CGI-149 Homo sapiens (Human) apoptotic process [GO:0006915]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of cytokinesis [GO:0032467]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endosome size [GO:0051036]; regulation of mitotic spindle assembly [GO:1901673]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin-specific protease binding [GO:1990381]" DGIWLVQVNEWSLK;EMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDR 2 19.5 0.93685 -0.55089 0 0 10.2346 0 0 0 0 0 0 0 0 10.8975 Q9Y3F4 STRAP_HUMAN Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) STRAP MAWD UNRIP Homo sapiens (Human) "alternative mRNA splicing, via spliceosome [GO:0000380]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; spliceosomal snRNP assembly [GO:0000387]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; U2 snRNP binding [GO:1990447] AATAAADFTAK;GAVWGATLNK 2 6 0.96286 -1.0815 0 0 0 0 9.56562 0 0 0 0 11.2203 0 0 Q9Y3I0 RTCB_HUMAN RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) RTCB C22orf28 HSPC117 Homo sapiens (Human) "in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA ligase (GTP) activity [GO:0170057]; vinculin binding [GO:0017166] AIKLRPIAVIK;EGYAWAEDK;LADMGIAIR;MSRSYNDELQFLEK;SYNDELQFLEK 5 8.5 0.97294 -2.9474 10.3741 0 0 5.90111 0 0 7.51538 0 0 0 0 0 Q9Y3I1 FBX7_HUMAN F-box only protein 7 FBXO7 FBX7 Homo sapiens (Human) autophagy of mitochondrion [GO:0000422]; lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of mitophagy [GO:1901526]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] DLFTASNDPLLWR;SVKRLQLLPESFICK 2 5.4 0.8408 -0.043817 0 0 0 0 0 0 8.16992 0 10.195 0 0 0 Q9Y3L3 3BP1_HUMAN SH3 domain-binding protein 1 SH3BP1 Homo sapiens (Human) "actin filament organization [GO:0007015]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; establishment of epithelial cell apical/basal polarity [GO:0045198]; filopodium assembly [GO:0046847]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of Rac protein signal transduction [GO:0035020]; regulation of small GTPase mediated signal transduction [GO:0051056]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]" adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; semaphorin receptor binding [GO:0030215]; SH3 domain binding [GO:0017124] LSEEELPAILKHK 1 1.9 0.92174 -0.44684 0 0 0 0 0 0 0 0 0 0 9.20176 0 Q9Y3M8 STA13_HUMAN StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) STARD13 DLC2 GT650 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] DLPEPLFTNK;GKGAHGRHK;IRNSFQPLIAEGPETKI;VNHTFQR 4 3.9 0.97534 -3.3634 0 0 0 7.5672 0 0 0 0 11.5379 0 0 10.3611 Q9Y3M9 ZN337_HUMAN Zinc finger protein 337 ZNF337 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GQDFSRK 1 0.9 0.37017 0.2257 0 0 0 0 0 0 0 0 0 8.23103 0 0 Q9Y3P4 RHBD3_HUMAN Rhomboid domain-containing protein 3 RHBDD3 C22orf3 Homo sapiens (Human) liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of protein catabolic process [GO:0045732]; regulation of acute inflammatory response [GO:0002673]; regulation of protein secretion [GO:0050708]; response to xenobiotic stimulus [GO:0009410] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] TLAGCWPLR 1 2.3 0.91695 -0.42971 0 0 0 0 0 0 0 11.6086 0 0 0 0 Q9Y3P9 RBGP1_HUMAN Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) RABGAP1 HSPC094 Homo sapiens (Human) regulation of GTPase activity [GO:0043087] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631] ELDKAESEIK;LEQENDDLAHELVTSK;LQEANMR;RLQEANMR 4 3.2 0.97308 -2.5049 0 0 0 9.7702 7.7998 0 0 0 0 0 0 0 Q9Y3Q0 NALD2_HUMAN N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) proteolysis [GO:0006508] membrane [GO:0016020]; plasma membrane [GO:0005886] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; serine-type peptidase activity [GO:0008236] ANSRLAWKEVK;ETTTSVRYHQSIR;EVKKHISIAAFTIQAAAGTLK;IIPFNIQDYAEALK;NLPRINK;VDCTPLLYQLVYKLTK 6 10.7 0.96653 -1.2813 8.54326 0 0 15.1124 15.2795 15.1284 13.8731 6.41566 0 9.5772 10.2126 0 Q9Y3Q4 HCN4_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Homo sapiens (Human) blood circulation [GO:0008015]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; monoatomic cation transport [GO:0006812]; muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; SA node cell action potential [GO:0086015]; sinoatrial node development [GO:0003163]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellularly cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in SA node cell action potential depolarization [GO:0086041]; voltage-gated sodium channel activity [GO:0005248] FTKILSLLRLLR;IDSEVYKTARALR;ILSLLRLLRLSR 3 2.3 0.95983 -1.0452 0 0 0 0 0 10.2753 0 0 0 0 0 0 Q9Y3Q7 ADA18_HUMAN "Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III)" ADAM18 TMDC3 UNQ858/PRO1867 Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] CCDYNTCK;GAQGAPFACFKEVNSLHER;LACVQPHKNANK 3 5.3 0.97949 -1.8877 0 0 0 0 0 7.17473 0 0 0 4.86967 0 0 Q9Y3R0 GRIP1_HUMAN Glutamate receptor-interacting protein 1 (GRIP-1) GRIP1 Homo sapiens (Human) "intracellular signal transduction [GO:0035556]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection arborization [GO:0150012]" cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] beta-catenin binding [GO:0008013]; signaling receptor complex adaptor activity [GO:0030159] EIMSPTPVELHKVTLYK;GKPLSEAIHLLQMAGETVTLKIKK;ILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK;KPGDPLVISDIKK;LTKDESPYTK 5 6.6 0.97803 -1.5287 0 0 0 9.83346 0 0 0 7.55651 0 6.44806 9.96464 0 Q9Y3R4 NEUR2_HUMAN Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2) NEU2 Homo sapiens (Human) ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid catabolic process [GO:0046479]; oligosaccharide catabolic process [GO:0009313] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020] exo-alpha-sialidase activity [GO:0004308] QAFPAEYLPQ;SLVVPAYAYR 2 5.3 0.94465 -0.63949 0 0 0 0 0 0 0 9.98854 0 0 0 0 Q9Y3R5 DOP1B_HUMAN Protein DOP1B DOP1B C21orf5 DOPEY2 KIAA0933 Homo sapiens (Human) cognition [GO:0050890]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum organization [GO:0007029]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] ALSLGDVAR;AQRHSKMK;ILDFLNPLTAHLGVQLTAAVAAVWSRKK;ILEPVLLLLLQPK;ILEPVLLLLLQPKTQRTSIHCLK;KGGSMQR;LQMVTVPPIAPGILKVIAEK;SIIDHLLTHEK;VVIDLGGSR 9 5 0.97272 -2.6116 9.66121 10.1424 15.8642 7.81775 0 5.34031 0 0 8.11432 9.66436 0 0 Q9Y3S1 WNK2_HUMAN Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AGVGMPR;DVPGTLMEPGR;LEGRAAR;MDGDGGR;QPPDSAPYKDQLSSK;QVASDSHVVPSVPQDVPAFVRPARVEPTDR;VALIQWR 7 3.7 0.98055 -2.0167 9.5566 5.29326 0 0 6.28512 0 4.92339 0 9.05715 10.2229 8.90469 0 Q9Y3S2 ZN330_HUMAN Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) ZNF330 NOA36 Homo sapiens (Human) "chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] AENRRER;CKACFCDDHTR 2 5.6 0.98109 -1.7105 0 0 0 0 0 0 4.07202 0 0 0 0 0 Q9Y3T6 R3HC1_HUMAN R3H and coiled-coil domain-containing protein 1 R3HCC1 Homo sapiens (Human) nucleic acid binding [GO:0003676] ALQRPKLLR;APASCPSR;QEEWGLTSTSVLKREAPAGR 3 8.4 0.95317 -0.73396 0 5.79423 0 0 4.52356 0 0 7.58353 0 0 7.30186 0 Q9Y3T9 NOC2L_HUMAN Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) NOC2L NIR Homo sapiens (Human) apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal large subunit biogenesis [GO:0042273]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromosome [GO:0005694]; cytosol [GO:0005829]; Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] AAVATTRGDQESAEANK;EEGTPLTLYYSHWRK;LLFGKVAKDSSR;NSVPVTVAMVER 4 7.5 0.97993 -1.8318 0 0 0 9.49755 0 0 0 0 6.85885 9.3168 0 10.9998 Q9Y3U8 RL36_HUMAN Large ribosomal subunit protein eL36 (60S ribosomal protein L36) RPL36 Homo sapiens (Human) cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EELSNVLAAMR;MALRYPMAVGLNK;YPMAVGLNK 3 22.9 0.94492 -0.62428 0 0 0 0 9.0797 0 0 0 10.8427 11.0799 8.08396 0 Q9Y3X0 CCDC9_HUMAN Coiled-coil domain-containing protein 9 CCDC9 Homo sapiens (Human) exon-exon junction complex [GO:0035145] RNA binding [GO:0003723] AATLDLK;AGLGSAGDMTLSMTGRERSEYLR;EWDAEKTDGMFK;NLGPSRR 4 9.2 0.98023 -1.7146 0 12.1694 11.1394 12.4247 0 0 0 0 0 0 7.08247 0 Q9Y3Y2 CHTOP_HUMAN Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) chromatin remodeling [GO:0006338]; mRNA export from nucleus [GO:0006406]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of helicase activity [GO:0051096] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346] methyl-CpG binding [GO:0008327]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GAMGRGGIGGRGR;GLPIIQRGLPRGGLR 2 11.3 0.96564 -1.2447 0 0 0 0 0 0 0 0 0 7.5627 0 0 Q9Y3Z3 SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) SAMHD1 MOP5 Homo sapiens (Human) dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; tetraspanin-enriched microdomain [GO:0097197] deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] EVGNLYDMFHTRNSLHR;IIDTPQFQR;LTDNIFLEILYSTDPKLKDAR;YVGETQPTGQIK 4 9.4 0.95723 -0.999 0 11.081 0 0 0 0 11.4214 0 10.4895 0 6.31839 0 Q9Y421 FA32A_HUMAN Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12) FAM32A OTAG12 CGI-144 Homo sapiens (Human) apoptotic process [GO:0006915] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ILKKASK;RTPAQAAFEK;THKQRVEDFNR 3 25 0.91035 -0.28885 0 8.18339 0 0 0 0 0 10.0293 0 0 1.64053 0 Q9Y446 PKP3_HUMAN Plakophilin-3 PKP3 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; desmosome assembly [GO:0002159]; desmosome organization [GO:0002934]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of protein localization [GO:1903829]; protein localization to plasma membrane [GO:0072659]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of hair follicle development [GO:0051797] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cadherin binding involved in cell-cell adhesion [GO:0098641]; cell adhesion molecule binding [GO:0050839]; enzyme binding [GO:0019899]; RNA binding [GO:0003723] AASSLLANLWQYNKLHRDFR;EQDDELRK;NLSYRLYDEMPPSALQR;SLQAVPRLVK;TSGFRPIAKPAYSPASWSSR 5 9.4 0.82966 -0.021768 0 0 0 0 0 10.303 0 8.56468 0 9.36829 0 10.4941 Q9Y448 SKAP_HUMAN Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) KNSTRN C15orf23 SKAP TRAF4AF1 HSD11 Homo sapiens (Human) cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; chromosome segregation [GO:0007059]; microtubule cytoskeleton organization [GO:0000226]; mitotic sister chromatid segregation [GO:0000070]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; spindle pole [GO:0000922] microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803] ATDTATR;NQLLEAVNK 2 5.1 0.9521 -0.74778 0 0 12.5718 0 0 0 0 8.37421 0 0 0 11.7519 Q9Y450 HBS1L_HUMAN HBS1-like protein (EC 3.6.5.-) (ERFS) HBS1L HBS1 KIAA1038 Homo sapiens (Human) "nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]" cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] ELSLANLIHDMSR;LYSCLDHMR 2 3.5 0.88584 -0.19535 0 0 0 8.35178 0 0 0 0 0 0 10.284 12.4724 Q9Y458 TBX22_HUMAN T-box transcription factor TBX22 (T-box protein 22) TBX22 TBOX22 Homo sapiens (Human) cell fate specification [GO:0001708]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" QYHVAIDVVPVDSK 1 2.7 0.78362 0.023586 0 0 0 0 0 0 0 10.2596 0 0 0 0 Q9Y462 ZN711_HUMAN Zinc finger protein 711 (Zinc finger protein 6) ZNF711 CMPX1 ZNF6 Homo sapiens (Human) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" GFRQQNELK;LEHMGNTPLK;THEFTEYTRRYR;VDKTHEFTEYTRR 4 4.5 0.96007 -1.0489 11.4794 13.0792 0 0 0 0 0 9.57355 0 0 0 0 Q9Y463 DYR1B_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) DYRK1B MIRK Homo sapiens (Human) adipose tissue development [GO:0060612]; DNA repair [GO:0006281]; myoblast fusion [GO:0007520]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; transcription coactivator activity [GO:0003713] IYQYIQSRFYR;MLEYEPAAR;SAIKIVDFGSSCQLGQR 3 5.9 0.97344 -2.557 10.2404 0 0 10.7677 0 0 0 0 0 0 0 0 Q9Y466 NR2E1_HUMAN Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll) NR2E1 TLX Homo sapiens (Human) aggressive behavior [GO:0002118]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; anterior commissure morphogenesis [GO:0021960]; apoptotic process [GO:0006915]; astrocyte cell migration [GO:0043615]; astrocyte differentiation [GO:0048708]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cerebral cortex neuron differentiation [GO:0021895]; dentate gyrus development [GO:0021542]; extracellular matrix organization [GO:0030198]; forebrain generation of neurons [GO:0021872]; layer formation in cerebral cortex [GO:0021819]; long-term synaptic potentiation [GO:0060291]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; olfactory bulb development [GO:0021772]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of dendrite morphogenesis [GO:0048814]; regulation of timing of neuron differentiation [GO:0060164]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic stem cell population maintenance [GO:0035019]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" AVPTHSGSELRSFR;LKKCLEVNMNK;QVALYFRGHK 3 9.1 0.97442 -3.6463 0 11.8107 0 0 0 0 0 0 0 9.71249 0 0 Q9Y468 LMBL1_HUMAN Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1) L3MBTL1 KIAA0681 L3MBT L3MBTL Homo sapiens (Human) chromatin organization [GO:0006325]; hemopoiesis [GO:0030097]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of cell cycle [GO:0051726]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitotic nuclear division [GO:0007088] chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; condensed chromosome [GO:0000793]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; nucleosome binding [GO:0031491]; SAM domain binding [GO:0032093]; zinc ion binding [GO:0008270] ECWSWESYLEEQK;HHGRIGRPPKYR;NLSGFSPR;VTHVSGK;YLEETGASAVPTWAFK 5 6.7 0.95257 -0.75091 9.33885 0 2.48078 0 0 8.61886 0 0 0 0 12.0142 0 Q9Y471 CMAH_HUMAN Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase-like protein) (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene) CMAHP CMAH Homo sapiens (Human) CMP-N-acetylneuraminate metabolic process [GO:0046381]; regulation of Wnt signaling pathway [GO:0030111] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634] CMP-N-acetylneuraminate monooxygenase activity [GO:0030338] DPDIYHHLFWNHFQIK;YIKETNTKNDPNELNNLIK 2 7.2 0.3788 0.21889 0 0 0 0 10.1571 0 0 0 0 8.01558 0 0 Q9Y473 ZN175_HUMAN Zinc finger protein 175 (Zinc finger protein OTK18) ZNF175 Homo sapiens (Human) defense response to virus [GO:0051607]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CQEREFGLEIPQK;SILSMHQRIHTGEKPYK 2 4.2 0.9299 -0.46723 0 6.77083 6.45887 0 0 0 0 9.08887 0 0 0 0 Q9Y483 MTF2_HUMAN Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) MTF2 PCL2 Homo sapiens (Human) "cellular response to leukemia inhibitory factor [GO:1990830]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression, epigenetic [GO:0045814]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]" cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222] EVSNGIEKK;LHPGELADTPK;VTLDGKVQYLVEWEGATAS 3 6.6 0.942 -0.62047 0 0 0 0 0 7.56186 0 0 8.98473 0 0 0 Q9Y484 WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) WDR45 WDRX1 WDRXI4 WIPI4 JM5 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] "phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]" FSEISVLIWDDAR;LFEFDTRDNPK 2 6.7 0.97994 -1.5385 0 0 0 0 7.23266 7.3361 0 0 0 7.7703 8.17383 0 Q9Y485 DMXL1_HUMAN DmX-like protein 1 (X-like 1 protein) DMXL1 XL1 Homo sapiens (Human) vacuolar acidification [GO:0007035] RAVE complex [GO:0043291] KTRPFYRASSFLDTSK;QEEIQETFIKNIFTKK;QSNSSSGLHPPKKTLTR;RQWLLKYQSLLR;SLLHMWNLHLK;SLTISASGSTTR;STSMLISSGHNK 7 3.2 0.95471 -0.95155 6.93263 0 0 0 0 7.12887 10.7093 7.25229 5.568 4.42344 7.95664 0 Q9Y487 VPP2_HUMAN V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) ATP6V0A2 Homo sapiens (Human) cellular response to increased oxygen levels [GO:0036295]; Golgi lumen acidification [GO:0061795]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035] "acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" FTEGFQNIVDAYGVGSYR;QVLEMQEQLQKLEVELR;VTKTFVK;WYVFLISFWGEQIGHKVK 4 7 0.96362 -1.0948 9.21383 7.17353 0 0 0 0 0 0 6.75836 0 9.98214 8.31188 Q9Y490 TLN1_HUMAN Talin-1 TLN1 KIAA1027 TLN Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; platelet aggregation [GO:0070527]; regulation of focal adhesion assembly [GO:0051893] adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] AAMEPIVISAK;AGFLDLKDFLPK;ALDGAFTEENR;AVAEQIPLLVQGVR;DVDNALRAVGDASKR;GLAGAVSELLR;GTPQDLAR;IPEAPAGPPSDFGLFLSDDDPKK;ISIGNVVK;LEQLKPRAKPK;LITSMRDK;LNEAAAGLNQAATELVQASR;LQAAGNAVK;TIMVDDSKTVTDMLMTICAR;TSTPEDFIR;TVSDSIK;VMVTNVTSLLK;VSQMAQYFEPLTLAAVGAASK 18 9 0.97519 -4.0216 0 12.3862 0 10.8831 8.13602 0 9.14167 12.3061 11.6793 12.3681 12.1307 11.5613 Q9Y493 ZAN_HUMAN Zonadhesin ZAN Homo sapiens (Human) binding of sperm to zona pellucida [GO:0007339]; cell-cell adhesion [GO:0098609] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] EKPPDQK;KLAGDSMQLGAAWK;LLLLSGEEGR;LSSNLVLLYTNFGLQVR;VTLWGQR;YHISELYDTLPSILCQPGRPRGLRGPLR 6 3 0.97962 -1.5477 13.0787 7.65456 0 0 0 9.40506 0 7.39395 0 0 0 9.48892 Q9Y496 KIF3A_HUMAN Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) KIF3A KIF3 Homo sapiens (Human) anterograde axonal transport [GO:0008089]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; organelle organization [GO:0006996]; plus-end-directed vesicle transport along microtubule [GO:0072383]; protein localization to cell junction [GO:1902414]; protein transport [GO:0015031] axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein phosphatase binding [GO:0019903]; small GTPase binding [GO:0031267]; spectrin binding [GO:0030507] IMTLGHK;QLSRELR;VSPDKMIEMQAK 3 3.7 0.97621 -2.2606 0 0 0 8.90848 0 0 0 0 5.62758 0 0 0 Q9Y4A0 JERKL_HUMAN Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG) JRKL Homo sapiens (Human) central nervous system development [GO:0007417] nucleus [GO:0005634] DNA binding [GO:0003677] KPRSFKSTDTLNLPVSYFSQK 1 4 0.52546 0.18665 0 0 0 0 0 0 0 0 0 0 0 6.65163 Q9Y4A5 TRRAP_HUMAN Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) DNA repair-dependent chromatin remodeling [GO:0140861]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; Swr1 complex [GO:0000812]; transcription factor TFTC complex [GO:0033276] transcription coregulator activity [GO:0003712] ACQLPLFSYIVER;FAIHKKIVLQVFHSLLK;GIAACMTCGNTKVLR;ILRAVVKIVEEWVK;IYQELVTKYSQQMVK;LDLQFQAIKIISIIVK;LFTMDLNVVEHK;LLAYCLLNYCK;LLNPCLEKR;LMSIFPTEPSTSSVASK;LNPEMLQIAQDTGKLNVAYFR;NVLSVMFR;QLQQGLAK;RGLSVDSAQEVKR;RLAVDLSEVVIKWELQR;SGAVSDAK;TIPNVIISHR;TLVCGVK;TVLRDEIIAWHKK 19 6.3 0.97585 -5.0612 0 0 5.89103 10.4034 0 10.4775 10.3751 9.50032 12.4789 12.6407 9.71347 0 Q9Y4A8 NF2L3_HUMAN "Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)" NFE2L3 NRF3 Homo sapiens (Human) integrated stress response signaling [GO:0140467]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VAAQNCRKR;YLEDTDR 2 2.3 0.91432 -0.33788 0 0 11.6971 0 0 0 0 0 0 0 0 0 Q9Y4A9 O10H1_HUMAN Olfactory receptor 10H1 (Olfactory receptor OR19-27) OR10H1 Homo sapiens (Human) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EIHHFACHVPPLLK;YNVLMSPR 2 6.9 0.94706 -0.65979 0 0 0 0 0 0 0 0 5.03144 0 0 0 Q9Y4B5 MTCL1_HUMAN Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) MTCL1 CCDC165 KIAA0802 SOGA2 Homo sapiens (Human) cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506] apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; kinetochore [GO:0000776]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; midbody [GO:0030496]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] AGGGATPVSSPSRSLR;DSYLEEDVYQLQELRRELDR;ELQAFLEQVNR;GAPTPSPAAR;KTFNQDDSADLR;LGELGSSAESK;LLEHALKEER;LQPPGQHHR;VDSITAAGGEGPFPTSRAR 9 6.2 0.97435 -3.8178 0 0 0 0 4.90665 9.79355 0 0 3.77716 12.4793 0 7.82947 Q9Y4B6 DCAF1_HUMAN DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) DCAF1 KIAA0800 RIP VPRBP Homo sapiens (Human) B cell differentiation [GO:0030183]; cell competition in a multicellular organism [GO:0035212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein catabolic process [GO:0045732]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; V(D)J recombination [GO:0033151] centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; nuclear estrogen receptor binding [GO:0030331]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AVLELFDRYDGLRR;ELQLQEVALR;HLASLLLHNKFATEFVAHGGVQK;HLPSPPTLDSIITEYLREQHAR;MSQLIEKETEEYRK;QENKRPSPR 6 6.1 0.97513 -4.023 11.8471 0 0 0 9.36361 0 5.41092 5.62117 0 9.53111 9.73848 0 Q9Y4C0 NRX3A_HUMAN Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) NRXN3 C14orf60 KIAA0743 Homo sapiens (Human) adult behavior [GO:0030534]; axon guidance [GO:0007411]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; vocalization behavior [GO:0071625] cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023] DGFQGCLASVDLNGR;LARIADTK;LNDNEWHTVR;SLSTSIFEGGYKAHAPKWESK;YLRWDASTR 5 3.8 0.96715 -1.3079 0 0 7.93793 7.65421 0 0 0 0 0 0 0 0 Q9Y4C1 KDM3A_HUMAN Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA Homo sapiens (Human) androgen receptor signaling pathway [GO:0030521]; cellular response to leukemia inhibitory factor [GO:1990830]; formaldehyde biosynthetic process [GO:0046293]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid nucleus elongation [GO:0007290] chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; iron ion binding [GO:0005506]; nuclear androgen receptor binding [GO:0050681]; transcription coregulator activity [GO:0003712] FLGDQQR;FLGDQQRVFLSK;GSCTQPK;LPNYFVRPDLGPK;TTSDLSK 5 3 0.97501 -2.3662 0 0 0 0 0 9.48828 0 8.95829 0 8.16576 8.91695 0 Q9Y4C2 TCAF1_HUMAN TRPM8 channel-associated factor 1 (TRP channel-associated factor 1) TCAF1 FAM115A KIAA0738 Homo sapiens (Human) negative regulation of cell migration [GO:0030336]; positive regulation of anion channel activity [GO:1901529]; positive regulation of protein targeting to membrane [GO:0090314] plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] LGETTLEEWK;VVVTGHKVLFTVGK 2 2.6 0.95973 -1.0441 0 3.60478 0 0 0 0 0 0 0 0 0 0 Q9Y4C4 MFHA1_HUMAN Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1) MFHAS1 MASL1 Homo sapiens (Human) erythrocyte differentiation [GO:0030218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of inflammatory response [GO:0050728]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; regulation of macrophage activation [GO:0043030]; regulation of toll-like receptor signaling pathway [GO:0034121] cytoplasm [GO:0005737] GTP binding [GO:0005525]; protein phosphatase 2A binding [GO:0051721]; ubiquitin protein ligase binding [GO:0031625] LLLMGHK;LLYFEDSPALKEHVFHNLTRLIDILNVFFQR 2 3.6 0.94444 -0.63983 8.38879 0 11.4495 0 0 0 0 13.2486 0 0 0 0 Q9Y4C5 CHST2_HUMAN Carbohydrate sulfotransferase 2 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2) (GST-2) (N-acetylglucosamine 6-O-sulfotransferase 1) (GlcNAc6ST-1) (Gn6ST-1) CHST2 GN6ST Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of leukocyte tethering or rolling [GO:1903238]; sulfur compound metabolic process [GO:0006790] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] ALPPGALPRLLQAAPAAAPR;MPFLEAAGHKLGAKK 2 6.6 0.8705 -0.096 0 8.7085 0 0 0 0 0 0 0 0 0 0 Q9Y4C8 RBM19_HUMAN Probable RNA-binding protein 19 (RNA-binding motif protein 19) RBM19 KIAA0682 Homo sapiens (Human) positive regulation of embryonic development [GO:0040019] chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ATKPAVTLARKK;GFAFITFMFPEHAVK;KRPPEARAETEKPANQK;NLNFDTTEEKLK;NLPYTSTEEDLEK;RFLIDNGVSLDSFSQAAAER 6 9.3 0.9341 -0.51557 7.61154 0 10.2772 5.8588 0 0 2.78772 0 5.69524 0 0 3.01846 Q9Y4D1 DAAM1_HUMAN Disheveled-associated activator of morphogenesis 1 DAAM1 KIAA0666 Homo sapiens (Human) "presynaptic actin cytoskeleton organization [GO:0099140]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" ciliary basal body [GO:0036064]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; motile cilium [GO:0031514]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; stress fiber [GO:0001725] actin binding [GO:0003779]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] EHENSTLDR;IIQQIVIQNDKGQDPDSTPLENFNIK;SDIDLLEEHK;SGEVFDK 4 4.8 0.87292 -0.10968 0 0 0 0 0 0 0 4.52319 0 0 0 4.92989 Q9Y4D7 PLXD1_HUMAN Plexin-D1 PLXND1 KIAA0620 Homo sapiens (Human) angiogenesis [GO:0001525]; aorta development [GO:0035904]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; endothelial cell migration [GO:0043542]; kidney development [GO:0001822]; negative regulation of cell adhesion [GO:0007162]; negative regulation of neuron apoptotic process [GO:0043524]; outflow tract morphogenesis [GO:0003151]; positive regulation of axonogenesis [GO:0050772]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; synaptic target recognition [GO:0008039] axon [GO:0030424]; cell body [GO:0044297]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] protein domain specific binding [GO:0019904]; semaphorin receptor activity [GO:0017154] ILEAFCKNVPYSQWPR;LMLRRTESVVEK;RTESVVEK 3 1.5 0.91578 -0.43091 11.2121 0 0 0 0 0 0 0 0 0 8.20247 0 Q9Y4D8 HECD4_HUMAN Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein ubiquitination [GO:0016567] membrane [GO:0016020] ubiquitin-protein transferase activity [GO:0004842] ASSSGKRQSSR;FALLQSLNTTLETFFLPLVELR;LSIFIHK;RTATNGLVTLDNTNLQIHR;SPEKSKPDEK;TVETVHPVR;VLEDQLTQILR;VLVYGLGHK;VYFTYCGQR 9 2.7 0.97586 -4.4272 13.9563 13.6372 13.8678 0 8.8289 0 7.86814 0 10.4196 4.71205 0 0 Q9Y4E1 WAC2C_HUMAN WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF) WASHC2C FAM21C KIAA0592 VPEF Homo sapiens (Human) "endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203] "phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394]" EDDLFAIAKDSQKK;EEKAKASELSK;TVLSLFDEEEDK;VTLSYSK 4 3.3 0.97295 -2.6621 0 0 0 0 0 0 0 0 0 8.85639 0 8.46005 Q9Y4E5 ZN451_HUMAN E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) ZNF451 COASTER KIAA0576 KIAA1702 Homo sapiens (Human) negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925] nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]" FPSEDAVEK;SHMELTAHFRVHCR;TLRSHMELTAHFRVHCR 3 2.5 0.95365 -0.78039 0 5.96072 0 0 0 0 9.43713 0 0 0 11.5933 0 Q9Y4E5 ZN451_HUMAN E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) ZNF451 COASTER KIAA0576 KIAA1702 Homo sapiens (Human) negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925] nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]" LVPPLHPLLRIATTEVFK 1 3.2 0.82834 -0.023565 0 3.94879 0 0 0 0 0 0 0 0 0 0 Q9Y4E6 WDR7_HUMAN WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) WDR7 KIAA0541 TRAG Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244] cytoplasm [GO:0005737] FYMVSYYERNHR;ISTSYEERRK;TLRGHRNK 3 2 0.94425 -0.63336 0 0 0 0 0 0 8.18903 0 0 6.04989 0 7.00248 Q9Y4E8 UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) USP15 KIAA0529 Homo sapiens (Human) BMP signaling pathway [GO:0030509]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K27-linked deubiquitination [GO:1990167]; proteolysis [GO:0006508]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin-modified histone reader activity [GO:0061649] DADGRPDKVVAEEAWENHLK;FSKADTIDTIEKEIR;KLDLWSLPPVLVVHLKR;LDLWSLPPVLVVHLKRFSYSR;LVSWYTLMEGQEPIAR;YFDENAAEDFEK 6 8.7 0.95535 -0.96807 0 5.27769 0 0 9.03928 10.399 0 0 0 0 0 0 Q9Y4F1 FARP1_HUMAN "FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)" FARP1 CDEP PLEKHC2 Homo sapiens (Human) dendrite morphogenesis [GO:0048813]; enzyme-linked receptor protein signaling pathway [GO:0007167]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; regulation of presynapse assembly [GO:1905606]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; synapse assembly [GO:0007416] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978] cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] GQRQSIIVAASSRSEMEK;INAFNWAK;KHSKIHSIR;LSGKGLQQRMFFLFNDVLLYTSR;QVLERLCKHHPPSHADFR 5 7.3 0.96743 -1.3222 0 9.33282 13.1988 10.5016 0 0 0 4.81747 0 0 7.73802 0 Q9Y4F3 MARF1_HUMAN Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) MARF1 KIAA0430 LKAP Homo sapiens (Human) double-strand break repair [GO:0006302]; female meiotic nuclear division [GO:0007143]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; peroxisome [GO:0005777] CCR4-NOT complex binding [GO:1905762]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] ILEVPESHTASELK;ILTLTEVERFKALAAQFVK;RMENEDVFGNRIIVSFTPK;VADIESGRQIQLINRK;WIHNKPPPPNTDPWLLRSK 5 5 0.9731 -2.5861 0 0 11.4252 0 0 0 9.30743 11.3913 0 6.94392 9.6137 0 Q9Y4F4 TGRM1_HUMAN TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B) TOGARAM1 FAM179B KIAA0423 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881] microtubule binding [GO:0008017] DKDLDQEEMHSSLR;LPSALRRHYNR;RGLNGTKPVPPIPR;VLSAGKGKNK 4 2.8 0.91973 -0.43824 0 10.4232 0 0 0 0 0 0 0 0 0 0 Q9Y4F4 TGRM1_HUMAN TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B) TOGARAM1 FAM179B KIAA0423 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881] microtubule binding [GO:0008017] DLDQEEVR;EKNFSYC;LPSALRRHYNR;RGLNGTKPVPPIPR;VLSAGKGKNK 5 5 0.97483 -3.2016 0 0 0 11.9047 8.16982 0 0 0 0 13.3103 0 10.4111 Q9Y4F5 C170B_HUMAN Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) cytoplasm [GO:0005737]; microtubule [GO:0005874] EISSILK;ELIFVGR;VGPGDDR;VPEEALK 4 1.8 0.95278 -0.76825 0 0 0 0 0 0 0 0 12.3195 0 6.26136 0 Q9Y4G2 PKHM1_HUMAN Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) PLEKHM1 KIAA0356 Homo sapiens (Human) autophagosome-lysosome fusion [GO:0061909]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]; protein transport [GO:0015031] autolysosome [GO:0044754]; autolysosome membrane [GO:0120281]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleolus [GO:0005730] metal ion binding [GO:0046872] TVFHQSCQAVVKK 1 1.2 0.72162 0.13333 0 0 0 0 0 0 8.96084 0 0 0 0 0 Q9Y4G6 TLN2_HUMAN Talin-2 TLN2 KIAA0320 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; presynaptic actin cytoskeleton organization [GO:0099140] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle [GO:0001726]; synapse [GO:0045202] actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] AVQPTSGEPR;DSVMRVDEK;ETAQALK;HKPGFLDLKEFLPK;KQRPQKIR;LDEGTPPEPK;LEQLKPRAKPK;LQAAGNAVK;VMVTNVTSLLK 9 3.5 0.9732 -2.914 0 0 15.3207 0 0 0 0 8.24608 0 0 10.9952 0 Q9Y4G8 RPGF2_HUMAN Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 Homo sapiens (Human) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase-mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] beta-1 adrenergic receptor binding [GO:0031697]; calcium ion binding [GO:0005509]; cAMP binding [GO:0030552]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; WW domain binding [GO:0050699] ASYVDNSFR;ASYVDNSFRQAVMKNPPER;EVVIQAIR;ILNQVEKNMQK;LLEWFNDPSLR;NIEPTEYIDDLFK;RGDQILEVNGQNFENIQLSK;RNGAPHLPK 8 5.5 0.97543 -3.3946 0 5.60543 5.29319 0 0 0 10.9602 10.737 12.812 12.4378 7.08449 0 Q9Y4H2 IRS2_HUMAN Insulin receptor substrate 2 (IRS-2) IRS2 Homo sapiens (Human) brain development [GO:0007420]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide [GO:1901653]; epithelial cell migration [GO:0010631]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; lipid homeostasis [GO:0055088]; mammary gland development [GO:0030879]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of kinase activity [GO:0033673]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of lipid metabolic process [GO:0019216]; response to glucose [GO:0009749]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 14-3-3 protein binding [GO:0071889]; insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] ASSPAESSPEDSGYMRMWCGSK 1 1.6 0.82896 -0.025381 0 0 0 0 0 0 0 0 0 0 0 6.95513 Q9Y4I1 MYO5A_HUMAN "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; melanosome transport [GO:0032402]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; insulin-responsive compartment [GO:0032593]; melanosome [GO:0042470]; membrane [GO:0016020]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; ruffle [GO:0001726] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] AKEEERPQIR;CALFEKPRLSNKAFIIQHFADK;CIEEHADR;DLEYHLDPK;DYKCLVEK;EAIQPKDDK;LEQEEYMK;NELNELRK;NTMTDSTILLEDVQK;QLELDLNDERLR;TIQMRLR;TIRGWLLRK;VLLLHLEEGK;VLMEQLTSVSEELDVR 14 8.1 0.97692 -5.6344 0 12.8049 10.7023 8.75047 7.7866 12.7703 0 12.4085 12.4089 11.9762 7.42878 11.2181 Q9Y4I5 MTL5_HUMAN "Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein)" TESMIN MTL5 Homo sapiens (Human) cell differentiation [GO:0030154]; intracellular monoatomic cation homeostasis [GO:0030003]; male meiotic nuclear division [GO:0007140]; regulation of DNA-templated transcription [GO:0006355]; response to metal ion [GO:0010038]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] metal ion binding [GO:0046872] AIKACLGR;CLSQILHTEFKSKGLK 2 4.7 0.91659 -0.41055 0 0 0 0 0 0 9.62518 0 0 0 0 8.92573 Q9Y4J8 DTNA_HUMAN Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) DTNA DRP3 Homo sapiens (Human) chemical synaptic transmission [GO:0007268]; neuromuscular synaptic transmission [GO:0007274]; signal transduction [GO:0007165]; striated muscle contraction [GO:0006941]; synaptic signaling [GO:0099536] axon [GO:0030424]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202] PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270] EILQEIQRLR;MIEDSGK 2 2.3 0.91403 -0.33013 0 0 0 0 0 0 0 0 0 0 7.50486 0 Q9Y4K0 LOXL2_HUMAN Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) LOXL2 Homo sapiens (Human) collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein modification process [GO:0036211]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040] basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720] NGEWGTVCDDK 1 1.4 0.30202 0.25105 0 0 0 0 0 0 0 0 0 9.26285 0 0 Q9Y4K1 CRBG1_HUMAN Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein) CRYBG1 AIM1 Homo sapiens (Human) carbohydrate binding [GO:0030246] AEDCGDWDDMEK;GQRNTPASSK;ISLFENK;ISLFENKRTNSSPR;SLRFIDVEFSEPTIILFER;SLRFIDVEFSEPTIILFEREDFK;VTLPAKPKHVELNLK 7 3.5 0.97518 -3.6157 7.72014 0 8.35023 9.86369 0 0 0 0 11.0819 0 0 0 Q9Y4K3 TRAF6_HUMAN TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) TRAF6 RNF85 Homo sapiens (Human) activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; CD40 signaling pathway [GO:0023035]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon production [GO:0032481]; protein autoubiquitination [GO:0051865]; protein branched polyubiquitination [GO:0141198]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of immunoglobulin production [GO:0002637]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; response to interleukin-1 [GO:0070555]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein kinase B binding [GO:0043422]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] CPNEGCLHKMELR;EIHDQNCPLANVICEYCNTILIR;GFGYVTFMHLEALRQR;QVSCDNCAASMAFEDK 4 13 0.93678 -0.55713 0 7.22265 0 0 8.34074 0 0 0 4.26791 0 0 10.6164 Q9Y4L1 HYOU1_HUMAN Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) HYOU1 GRP170 HSPH4 ORP150 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931] endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; smooth endoplasmic reticulum [GO:0005790] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] DAVVYPILVEFTR;GVGDSFKK;KVITFNR;LAGLFNEQR;QKPARKR;TKEAGMQPQLQIR;YPDYESK 7 6.4 0.82579 -0.019284 0 0 0 0 0 0 0 0 0 8.34087 0 0 Q9Y4L1 HYOU1_HUMAN Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) HYOU1 GRP170 HSPH4 ORP150 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931] endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; smooth endoplasmic reticulum [GO:0005790] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] CRARPAWR;DAVVYPILVEFTR;GVGDSFKK;KVITFNR;LAGLFNEQR;LPQSKQAIDR;TKEAGMQPQLQIR;YPDYESK 8 13.4 0.94691 -0.65906 0 7.78816 10.302 8.00921 10.9694 0 9.39772 4.03175 11.4408 0 0 0 Q9Y4L5 RN115_HUMAN E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364) RNF115 ZNF364 Homo sapiens (Human) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] GHQTHTDFWGARPPRLPLGRR 1 6.9 0.52771 0.18665 0 0 0 0 0 0 0 0 0 0 4.49685 0 Q9Y4P1 ATG4B_HUMAN Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) ATG4B APG4B AUTL1 KIAA0943 Homo sapiens (Human) aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; microautophagy [GO:0016237]; mitophagy [GO:0000423]; otolith mineralization completed early in development [GO:0031173]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein processing [GO:0016485]; protein transport [GO:0015031]; proteolysis [GO:0006508] autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; scaffold protein binding [GO:0097110] KRQPDSYFSVLNAFIDR;TSRRPTTRPHAARGAPR 2 7.3 0.88183 -0.16085 0 0 0 0 0 8.9816 0 0 0 0 9.43848 0 Q9Y4P3 TBL2_HUMAN Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) TBL2 WBSCR13 UNQ563/PRO1125 Homo sapiens (Human) cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum unfolded protein response [GO:0030968] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation initiation factor binding [GO:0031369] ANGFPPDK 1 1.8 0.93364 -0.49773 0 0 0 0 0 0 0 0 9.60731 0 0 0 Q9Y4P8 WIPI2_HUMAN WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) WIPI2 CGI-50 Homo sapiens (Human) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]" LATASEK 1 1.5 0.90856 -0.30941 0 0 0 0 0 0 0 0 0 0 0 8.31646 Q9Y4P9 SPEF1_HUMAN Sperm flagellar protein 1 SPEF1 C20orf28 Homo sapiens (Human) "axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]" 9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; stress fiber [GO:0001725] actin binding [GO:0003779]; microtubule binding [GO:0008017] NVRIEDLSR 1 3.8 0.97798 -1.5043 0 0 0 0 0 0 0 0 0 0 11.3097 0 Q9Y4R7 TTLL3_HUMAN Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; protein modification process [GO:0036211]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; tubulin-glycine ligase activity [GO:0070738]" RLSPLKPLPLVGTFQRR;VFISLPPNLDFKVAPSILKPRK 2 5.1 0.96565 -1.2578 0 0 0 0 0 0 6.52042 0 0 0 0 0 Q9Y4R8 TELO2_HUMAN Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) TELO2 KIAA0683 Homo sapiens (Human) 'de novo' cotranslational protein folding [GO:0051083]; positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]; TTT Hsp90 cochaperone complex [GO:0110078]" Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162] LLPPASP 1 0.8 0.70984 0.15802 0 0 8.14578 0 0 0 0 0 0 7.28142 0 0 Q9Y4U1 MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) MMACHC Homo sapiens (Human) cobalamin metabolic process [GO:0009235]; demethylation [GO:0070988]; glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737]; cytosol [GO:0005829] "cobalamin binding [GO:0031419]; cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity [GO:0033787]; demethylase activity [GO:0032451]; FAD binding [GO:0071949]; glutathione binding [GO:0043295]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]" ISGVCIHPRFGGWFAIR;KPGNPSR;KPGNPSRARSWLSPR 3 11.3 0.91792 -0.40898 12.5254 0 0 9.66183 0 0 0 0 0 10.3007 0 0 Q9Y4W6 AFG32_HUMAN Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) AFG3L2 Homo sapiens (Human) axonogenesis [GO:0007409]; calcium import into the mitochondrion [GO:0036444]; cellular response to glutathione [GO:0072753]; cristae formation [GO:0042407]; membrane protein proteolysis [GO:0033619]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial fusion [GO:0008053]; mitochondrial protein processing [GO:0034982]; mitochondrial protein quality control [GO:0141164]; muscle cell development [GO:0055001]; myelination [GO:0042552]; nerve development [GO:0021675]; neuromuscular junction development [GO:0007528]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of calcium import into the mitochondrion [GO:0110097]; regulation of multicellular organism growth [GO:0040014]; righting reflex [GO:0060013] m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent peptidase activity [GO:0004176]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GLGYAQYLPK;GPAGIGR;NPKQYQDLGAKIPK;SSGGGGGGGGK 4 5.3 0.95226 -0.75525 0 6.7952 8.9292 0 0 0 0 0 11.9098 8.14904 0 0 Q9Y4X4 KLF12_HUMAN Krueppel-like factor 12 (Transcriptional repressor AP-2rep) KLF12 AP2REP HSPC122 Homo sapiens (Human) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CDFEGCNK;FARSDELTRHYR 2 5 0.91384 -0.39033 0 0 0 0 0 0 0 0 0 6.06387 0 0 Q9Y4X5 ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1) ARIH1 ARI MOP6 UBCH7BP HUSSY-27 Homo sapiens (Human) PKR/eIFalpha signaling [GO:0039585]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lewy body [GO:0097413]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ILLSHFNWDKEKLMER;LLKWCPAPDCHHVVK;QKMEEMQQHNMSWIEVQFLK 3 9.2 0.96394 -1.1822 0 0 0 0 8.32039 0 0 0 13.3235 0 0 0 Q9Y4Z0 LSM4_HUMAN U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) LSM4 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]" cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] PH domain binding [GO:0042731]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] GVFGGRGR;KPGRQAGK 2 11.5 0.98188 -1.5813 6.03201 0 7.97865 10.4225 9.54019 9.62192 0 0 4.85932 0 0 5.494 Q9Y4Z2 NGN3_HUMAN Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) NEUROG3 ATOH5 BHLHA7 NGN3 Homo sapiens (Human) axon development [GO:0061564]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; forebrain development [GO:0030900]; hindbrain development [GO:0030902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of dendrite morphogenesis [GO:0048814]; sensory organ development [GO:0007423]; spinal cord development [GO:0021510]; transdifferentiation [GO:0060290] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVLPTFPDDAK 1 5.1 0.93437 -0.51575 0 0 0 0 0 0 0 9.91997 10.1805 0 0 0 Q9Y512 SAM50_HUMAN Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) SAMM50 SAM50 CGI-51 TRG3 Homo sapiens (Human) cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial respiratory chain complex assembly [GO:0033108]; protein insertion into mitochondrial outer membrane [GO:0045040] extracellular exosome [GO:0070062]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] LAECIRWSYGAGIVLR;NLIEVMRKSHEAR;TASFAVR 3 7.7 0.93696 -0.56156 0 0 0 10.0031 7.52097 0 0 0 0 0 0 0 Q9Y520 PRC2C_HUMAN Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) PRRC2C BAT2D1 BAT2L2 KIAA1096 XTP2 Homo sapiens (Human) hematopoietic progenitor cell differentiation [GO:0002244]; stress granule assembly [GO:0034063] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] RNA binding [GO:0003723] DRERQQEK;ISAVESQPSRKR;LQDEERR;LQDEERRK;QPRAGPIKAQK;VGENVLPPKREIAK;VTSRCIDSK 7 2.1 0.97533 -4.2714 0 11.4542 0 0 9.82042 10.989 0 0 8.89821 0 9.01058 0 Q9Y530 OARD1_HUMAN ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-) OARD1 C6orf130 TARG1 Homo sapiens (Human) DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734] ADP-ribosyl-[dinitrogen reductase] hydrolase activity [GO:0047407]; ADP-ribosylglutamate hydrolase activity [GO:0140293]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; purine nucleoside binding [GO:0001883] SLEAMKSHCLK 1 7.2 0.88499 -0.18113 0 0 0 0 8.44116 0 0 0 0 0 0 0 Q9Y534 CSDC2_HUMAN Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) CSDC2 PIPPIN Homo sapiens (Human) mRNA processing [GO:0006397]; regulation of mRNA stability [GO:0043488] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] DLPSPLPTK;EGSRVWER;SPVWPTFPFHR 3 18.3 0.94194 -0.59681 0 0 0 0 0 0 0 0 0 9.86655 0 9.99223 Q9Y536 PAL4A_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4A (PPIase A-like 4A) (EC 5.2.1.8) (Chromosome one-amplified sequence 2) (COAS-2) (Cyclophilin homolog overexpressed in liver cancer) PPIAL4A COAS2 PPIAL4B Homo sapiens (Human) protein folding [GO:0006457] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] ALSTGEK;HNGTGDK;TEWLDGK 3 12.8 0.71005 0.15645 0 0 0 0 0 0 0 0 0 0 0 6.37074 Q9Y543 HES2_HUMAN Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2) HES2 BHLHB40 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RARINQSLSQLK 1 15.8 0.97802 -1.509 0 0 10.8029 0 0 0 0 0 0 0 0 0 Q9Y546 LRC42_HUMAN Leucine-rich repeat-containing protein 42 LRRC42 Homo sapiens (Human) HEAISSQESKKSK;LQFYKEK 2 4.7 0.97223 -2.7226 0 0 0 0 0 0 0 0 0 8.30282 0 0 Q9Y547 IFT25_HUMAN Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Heat shock protein family B member 11) (Placental protein 25) (PP25) IFT25 C1orf41 HSPB11 HSPC034 Homo sapiens (Human) cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; kidney development [GO:0001822]; left/right axis specification [GO:0070986]; lung development [GO:0030324]; protein transport [GO:0015031]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] metal ion binding [GO:0046872] IEKSTSKEPVDFEQWIEK 1 12.5 0.95447 -0.91121 0 0 0 11.154 0 0 0 0 0 0 0 0 Q9Y548 YIPF1_HUMAN Protein YIPF1 (YIP1 family member 1) YIPF1 Homo sapiens (Human) vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] small GTPase binding [GO:0031267] EEDDELLGNDDSDKTELLAGQK;GSLLPIPGK 2 10.1 0.92887 -0.47199 0 0 0 0 0 0 0 0 0 10.0572 0 0 Q9Y561 LRP12_HUMAN Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) LRP12 ST7 Homo sapiens (Human) endocytosis [GO:0006897]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; regulation of growth [GO:0040008]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle receptor activity [GO:0005041] CIPEAWK;CVFESWVCDSQDDCGDGSDEENCPVIVPTR;DETNCTMCQK;DETNCTMCQKEEFPCSR;QLDNGVSGR;VYTCLPESLK 6 8.5 0.97936 -1.5423 0 0 0 0 0 6.03521 0 0 8.89821 0 0 6.62287 Q9Y566 SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) SHANK1 Homo sapiens (Human) adult behavior [GO:0030534]; associative learning [GO:0008306]; dendritic spine morphogenesis [GO:0060997]; determination of affect [GO:0050894]; habituation [GO:0046959]; long-term memory [GO:0007616]; negative regulation of actin filament bundle assembly [GO:0032232]; neuromuscular process controlling balance [GO:0050885]; olfactory behavior [GO:0042048]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; regulation of AMPA receptor activity [GO:2000311]; righting reflex [GO:0060013]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; vocalization behavior [GO:0071625] cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685] ankyrin repeat binding [GO:0071532]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; somatostatin receptor binding [GO:0031877]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160] AASAAMYVPARSGRGR;ALDPASPLGLALAARERALK;APVTSGRGPPSEDGPGVPPPSPR;CCELLLFNR;REGGWQNEARR;VGHRQVVNMIR;VVMVTRHPDMDEAVHKK 7 5 0.8733 -0.11542 7.94269 0 12.5335 0 0 8.61614 10.5605 6.45233 0 11.6198 7.40054 0 Q9Y570 PPME1_HUMAN Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPME1 PME1 PP2593 PRO0750 Homo sapiens (Human) G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482] nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] LDKDLTIGQMQGK;SLENAIEWSVK 2 6.2 0.78686 0.01775 0 0 0 0 4.74873 0 0 0 0 0 0 0 Q9Y570 PPME1_HUMAN Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPME1 PME1 PP2593 PRO0750 Homo sapiens (Human) G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482] nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] ITLDVTEDK;LDKDLTIGQMQGK 2 13.7 0.93564 -0.52882 0 0 0 0 0 0 0 0 11.9281 0 0 0 Q9Y572 RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) RIPK3 RIP3 Homo sapiens (Human) "activation of protein kinase activity [GO:0032147]; amyloid fibril formation [GO:1990000]; apoptotic signaling pathway [GO:0097190]; cellular response to hydrogen peroxide [GO:0070301]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; lymph node development [GO:0048535]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of necroptotic process [GO:0060545]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; programmed necrotic cell death [GO:0097300]; protein modification process [GO:0036211]; reactive oxygen species metabolic process [GO:0072593]; regulation of activated T cell proliferation [GO:0046006]; regulation of activation-induced cell death of T cells [GO:0070235]; regulation of adaptive immune response [GO:0002819]; regulation of apoptotic process [GO:0042981]; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000452]; regulation of T cell mediated cytotoxicity [GO:0001914]; regulation of type II interferon production [GO:0032649]; signal transduction [GO:0007165]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription coactivator activity [GO:0003713] IVNSKAISR 1 1.7 0.98099 -1.6064 0 0 0 11.8849 0 11.9157 0 0 0 0 0 0 Q9Y573 IPP_HUMAN Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) IPP KLHL27 Homo sapiens (Human) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] YEVFRLKWENMCILFNDHK 1 3.3 0.95902 -1.0368 6.21488 0 9.29907 6.00133 6.43403 0 0 0 0 0 0 0 Q9Y575 ASB3_HUMAN Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein localization to ciliary inversin compartment [GO:1904108]; protein localization to T-tubule [GO:0036371]; protein ubiquitination [GO:0016567]; regulation of cardiac muscle contraction [GO:0055117] cilium [GO:0005929]; cytosol [GO:0005829]; T-tubule [GO:0030315] ASNAWILQQHIATVPSLTHLCRLEIR;VLRKLLK 2 6.4 0.84956 -0.078113 0 0 7.98043 0 0 0 2.80519 0 0 0 0 0 Q9Y576 ASB1_HUMAN Ankyrin repeat and SOCS box protein 1 (ASB-1) ASB1 KIAA1146 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; male genitalia development [GO:0030539]; negative regulation of cytokine production [GO:0001818]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ALGKHRLHLIPSLPLPDPIK;LHLIPSLPLPDPIKK;SVPRTLLCLCR;TLLCLCR 4 9.6 0.91594 -0.39427 11.4811 0 0 7.73593 9.28811 3.39671 0 0 0 6.08511 0 0 Q9Y577 TRI17_HUMAN E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17) TRIM17 RBCC RNF16 TERF Homo sapiens (Human) autophagy [GO:0006914]; innate immune response [GO:0045087]; protein autoubiquitination [GO:0051865]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] KGSFPCPECR;RERIVLEFEK 2 4.2 0.97228 -1.3566 0 7.18497 0 0 0 0 0 0 0 0 11.3593 0 Q9Y580 RBM7_HUMAN RNA-binding protein 7 (RNA-binding motif protein 7) RBM7 Homo sapiens (Human) "meiotic cell cycle [GO:0051321]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; snRNA catabolic process [GO:0016076]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] 14-3-3 protein binding [GO:0071889]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069] DDFFYEDRNHDDWSHDYDNR;LYGRPIKIQFR;NHDDWSHDYDNRRDSSR 3 13.5 0.9097 -0.27968 0 0 4.34156 9.40071 0 9.06676 0 0 0 0 6.0966 0 Q9Y581 INSL6_HUMAN Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain] INSL6 RIF1 Homo sapiens (Human) extracellular region [GO:0005576] hormone activity [GO:0005179] PRLLRLSLLWLGLLLVR 1 8 0.56199 0.18254 0 0 0 0 0 0 0 0 0 4.80684 0 0 Q9Y586 MB212_HUMAN Protein mab-21-like 2 MAB21L2 Homo sapiens (Human) camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; embryonic body morphogenesis [GO:0010172]; eye development [GO:0001654]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284] cytoplasm [GO:0005737]; nucleus [GO:0005634] AAIAKTIREVCK;ETDWDESCLGDR;EVEVQEPR;FQTLVAQAVDKCSYR;LLMGGCRNK;TIREVCK 6 15.6 0.97535 -3.369 6.41711 0 0 0 0 3.15261 0 10.6127 0 2.25278 0 11.2822 Q9Y592 CEP83_HUMAN Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Renal carcinoma antigen NY-REN-58) CEP83 CCDC41 Homo sapiens (Human) cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802] FRNLDEEVEKYR;LADLEKMK;LIDERLRCEHHK;QIQWLEEK;VYLCQKLK 5 8.3 0.9758 -4.4241 13.421 0 0 0 5.47112 0 0 12.2813 0 0 0 0 Q9Y597 KCTD3_HUMAN BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) KCTD3 Homo sapiens (Human) protein homooligomerization [GO:0051260] plasma membrane [GO:0005886] GVSINVLR;SSEDENENK;VIVQHPETVGSGPQLFQTFTVHR;VVPITNKLFVRLSSTGK 4 7 0.96548 -1.135 0 3.5764 0 0 0 0 12.4723 0 0 0 0 0 Q9Y5A6 ZSC21_HUMAN Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) ZSCAN21 ZFP38 ZNF38 Homo sapiens (Human) cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSHSSNLTLHYRTHLVDRPYDCK;RTHTGEKPYVCTK;VEEKEEKGK 3 9.7 0.93693 -0.54231 0 0 0 0 0 0 11.2928 0 0 0 0 8.6376 Q9Y5A7 NUB1_HUMAN NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) NUB1 NYREN18 Homo sapiens (Human) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ACDGNVDHAATHITNRR;AMVLELKQSEEDARK;LECCENEVEKVIEEIRCK;LTQFLREDR;YFCECCR 5 10.7 0.97482 -3.0903 0 0 0 0 10.0682 0 0 12.0552 0 6.10178 0 10.916 Q9Y5A9 YTHD2_HUMAN YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) YTHDF2 HGRG8 Homo sapiens (Human) embryonic morphogenesis [GO:0048598]; endothelial to hematopoietic transition [GO:0098508]; gamete generation [GO:0007276]; hematopoietic stem cell proliferation [GO:0071425]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oocyte maturation [GO:0001556]; organelle assembly [GO:0070925]; positive regulation of cap-independent translational initiation [GO:1903679]; regulation of cell adhesion [GO:0030155]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of rRNA processing [GO:2000232]; spermatogonial cell division [GO:0007284]; stress granule assembly [GO:0034063] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] C5-methylcytidine-containing RNA reader activity [GO:0062153]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] APGMNTIDQGMAALK;LDAAYRSMNGK;LGSTEVASNVPK;LRSINNYNPK;SINNYNPK 5 8.3 0.9781 -1.9481 0 0 0 0 0 8.35103 10.5127 0 10.2392 0 9.57873 8.45063 Q9Y5B0 CTDP1_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) CTDP1 FCP1 Homo sapiens (Human) cell division [GO:0051301]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation by host of viral transcription [GO:0043923]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368] centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096] EVPAAGR;VEEQLFPLRDDHTK 2 2.2 0.96335 -1.0901 0 12.4651 0 0 0 0 0 0 0 0 0 0 Q9Y5B6 PAXB1_HUMAN PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) "mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription by RNA polymerase II [GO:0006366]" cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226] ALYQEHAK;DAYIGLCLPK;EDENDASDDEDDDEK;EDENDASDDEDDDEKR;KAQNVINCFPKQWFMNLK;RTLDDDVFMPLYPKNVLENK 6 7.9 0.97937 -1.5448 0 0 0 6.7703 0 10.4481 0 0 6.73782 11.1087 8.66089 5.10249 Q9Y5B9 SP16H_HUMAN FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) SUPT16H FACT140 FACTP140 Homo sapiens (Human) "DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]" FACT complex [GO:0035101]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleosome binding [GO:0031491]; RNA binding [GO:0003723] AALLTER;APGEQTVPALNLQNAFR;AVTLDKDAYYR;DLGFNGAPYR;ELAAQLNEEAK;ERVMEIVDADEK;GNENANGAPAITLLIR;HSSAPPK;NEGNIFPNPEATFVK;VEALTKEELEFEVPFR;VTMINAIPVASLDPIK;YEEEEEQSR 12 14 0 2.2502 0 12.1225 12.8139 0 0 0 10.2325 0 7.63365 9.28746 10.6387 11.9536 Q9Y5C1 ANGL3_HUMAN Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)] ANGPTL3 ANGPT5 UNQ153/PRO179 Homo sapiens (Human) acylglycerol homeostasis [GO:0055090]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; integrin-mediated signaling pathway [GO:0007229]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phospholipase activity [GO:0010519]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; response to hormone [GO:0009725]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027] enzyme inhibitor activity [GO:0004857]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859] FTIKLLLFIVPLVISSR;IDGSQNFNETWENYK;IELEDWK;ILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLK;TFVEKQDNSIK 5 18.3 0.97777 -1.5246 6.79168 9.63659 0 0 0 3.04571 11.376 10.5014 5.15809 0 6.55444 11.1797 Q9Y5E1 PCDB9_HUMAN Protocadherin beta-9 (PCDH-beta-9) (Protocadherin-3H) PCDHB9 PCDH3H Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] FLKPITPHLPPHRGGK;SLDYEALQAFDFRVGASDR 2 4.4 0.95582 -0.87138 5.99463 0 0 0 7.76944 0 0 0 0 0 0 0 Q9Y5E3 PCDB6_HUMAN Protocadherin beta-6 (PCDH-beta-6) PCDHB6 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] SLDYEALQSFEFR 1 1.6 0.80753 0.012117 0 0 0 0 0 0 0 0 0 6.24517 0 0 Q9Y5E4 PCDB5_HUMAN Protocadherin beta-5 (PCDH-beta-5) PCDHB5 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] ALDREERPELSLTLTALDGGAPPR;MHYKGNK 2 3.9 0.97451 -1.4246 0 0 0 0 0 0 11.3843 0 0 0 0 0 Q9Y5E5 PCDB4_HUMAN Protocadherin beta-4 (PCDH-beta-4) PCDHB4 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] QRLQLDRQTGDLLLR;QVLAFILMVFLSQVRLEPIR 2 4.4 0.89497 -0.24346 0 10.8041 0 0 0 4.4734 0 0 0 0 0 0 Q9Y5E8 PCDBF_HUMAN Protocadherin beta-15 (PCDH-beta-15) PCDHB15 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KYPELVLDTELDR;YSVMEETER 2 2.8 0.74016 0.10268 0 12.4615 0 0 0 0 0 4.17951 0 0 0 0 Q9Y5E9 PCDBE_HUMAN Protocadherin beta-14 (PCDH-beta-14) PCDHB14 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] KRQVLIFLVLLGLSR;RQVLIFLVLLGLSR 2 1.9 0.13557 0.35596 0 0 0 0 7.27249 0 3.88753 0 0 0 0 0 Q9Y5F2 PCDBB_HUMAN Protocadherin beta-11 (PCDH-beta-11) PCDHB11 Homo sapiens (Human) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] SYTISPNSHFHIKMR 1 1.9 0.81331 -0.01152 0 8.47293 0 0 0 0 0 0 0 0 0 0 Q9Y5F3 PCDB1_HUMAN Protocadherin beta-1 (PCDH-beta-1) PCDHB1 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GPLDFEAIETYDIDIQATDGGGLSAHSK 1 3.4 0.71388 0.14212 0 0 0 0 0 0 9.15522 0 0 0 0 0 Q9Y5F6 PCDGM_HUMAN Protocadherin gamma-C5 (PCDH-gamma-C5) PCDHGC5 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CLQGNADGDGGGGQCCR;FSGSLDR;RQDSPSPDFYK 3 4 0.96417 -1.1144 0 0 0 0 0 0 9.43788 0 9.11829 0 10.2909 4.93522 Q9Y5F7 PCDGL_HUMAN Protocadherin gamma-C4 (PCDH-gamma-C4) PCDHGC4 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEVEIVDVNDHAPR 1 1.5 0.79768 0.014791 9.0545 0 0 0 0 0 0 0 0 0 0 0 Q9Y5F8 PCDGJ_HUMAN Protocadherin gamma-B7 (PCDH-gamma-B7) PCDHGB7 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALGDKDSVRQR;VLVGDRNDNAPR;YTINIEAK 3 3.3 0.97664 -2.1946 0 0 0 9.9857 0 0 0 11.7001 0 0 5.83048 0 Q9Y5G1 PCDGF_HUMAN Protocadherin gamma-B3 (PCDH-gamma-B3) PCDHGB3 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IDREEICGKK;IVQDTKNTYR 2 2.2 0.93372 -0.49906 0 10.4911 0 0 0 0 0 0 0 0 5.43556 0 Q9Y5G2 PCDGE_HUMAN Protocadherin gamma-B2 (PCDH-gamma-B2) PCDHGB2 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLGLSVRDLPAR;FILKSSSKNYYK 2 2.6 0.9748 -1.4296 0 0 0 0 0 0 0 0 12.7642 0 0 0 Q9Y5G3 PCDGD_HUMAN Protocadherin gamma-B1 (PCDH-gamma-B1) PCDHGB1 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] growth cone [GO:0030426]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LESTSKNYYK 1 1.1 0.97499 -1.4556 0 0 0 0 0 0 0 0 11.3517 0 0 0 Q9Y5G4 PCDG9_HUMAN Protocadherin gamma-A9 (PCDH-gamma-A9) PCDHGA9 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; RNA binding [GO:0003723] AAPTKCQLRGR;EKASEYNITVTATDR;LRHWHSSHLLR;LVLLCSLLGMLWEARASQIR 4 6.1 0.97334 -2.5763 7.00607 0 0 10.3768 0 9.95776 10.8474 0 0 0 0 0 Q9Y5G8 PCDG5_HUMAN Protocadherin gamma-A5 (PCDH-gamma-A5) PCDHGA5 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLGLEPQELAERGVR 1 1.6 0.95342 -0.67565 0 0 0 0 9.61591 0 0 0 0 0 0 0 Q9Y5G9 PCDG4_HUMAN Protocadherin gamma-A4 (PCDH-gamma-A4) PCDHGA4 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ESCEKSEPLLITQDLLETK 1 2 0.91835 -0.43629 0 0 0 0 0 0 0 0 0 0 10.2082 0 Q9Y5H1 PCDG2_HUMAN Protocadherin gamma-A2 (PCDH-gamma-A2) PCDHGA2 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FGVEELELK;SHLIFPQPNYADTLISQESCEKK 2 3.4 0.91528 -0.3346 0 0 0 0 0 0 0 0 0 10.0086 0 0 Q9Y5H2 PCDGB_HUMAN Protocadherin gamma-A11 (PCDH-gamma-A11) PCDHGA11 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLGLEPRELAKR;FISLPPNCWCLGTSLLR 2 3.5 0.95772 -1.0007 0 0 0 0 0 0 0 0 0 0 8.29797 12.9525 Q9Y5H3 PCDGA_HUMAN Protocadherin gamma-A10 (PCDH-gamma-A10) PCDHGA10 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EELCAQSARCVVSFNILVEDRVK;GSFVGNISKDLGLAPRELAER 2 4.7 0.95555 -0.81365 0 0 0 0 0 9.41625 0 0 9.10803 0 0 0 Q9Y5H6 PCDA8_HUMAN Protocadherin alpha-8 (PCDH-alpha-8) PCDHA8 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GELGSWR;LLLLLLLLAAWK;LVPRSVGAGHVVAKVR;NYYSLVLDSALDR;RHRDLLEVSLQNGILFVNSR 5 7.2 0.87511 -0.12176 12.0128 0 4.23189 11.4855 12.347 11.5597 0 0 0 0 0 0 Q9Y5H7 PCDA5_HUMAN Protocadherin alpha-5 (PCDH-alpha-5) PCDHA5 CNRS6 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IDREELCRR;LLVLVKDHGEPPLTATATVLVSLVESGQAPK;NYYSLVLDSALDR;QEQRLFILESRMPDSR 4 7.4 0.96342 -1.0884 0 9.61743 0 0 0 0 0 10.8343 0 0 0 7.57645 Q9Y5H8 PCDA3_HUMAN Protocadherin alpha-3 (PCDH-alpha-3) PCDHA3 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DINDNAPVFPMAVK;QDVDVDLSAK 2 2.9 0.73152 0.11721 0 0 0 0 0 0 0 0 0 0 9.39624 12.2149 Q9Y5H9 PCDA2_HUMAN Protocadherin alpha-2 (PCDH-alpha-2) PCDHA2 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LDYEEAKSYEIQVTATDK;NYYSLVLDSALDR;VSLLLFLANSKIVLFKK 3 5.8 0.64059 0.1734 0 0 0 0 8.36929 9.37767 0 9.11811 0 8.72083 6.62176 9.08475 Q9Y5I0 PCDAD_HUMAN Protocadherin alpha-13 (PCDH-alpha-13) PCDHA13 CNRS5 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DINDNPPIFPESKK;LNATDPDDGTNGDIVYSFR;NYYSLVLDSALDR 3 4.8 0.412 0.20378 0 0 0 0 0 0 0 0 0 3.77947 5.99184 0 Q9Y5I2 PCDAA_HUMAN Protocadherin alpha-10 (PCDH-alpha-10) PCDHA10 CNRS8 Homo sapiens (Human) aorta development [GO:0035904]; aortic valve development [GO:0003176]; cell adhesion [GO:0007155]; gene expression [GO:0010467]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] cell-cell contact zone [GO:0044291]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] NYYSLVLDSALDR;SLSSYVSVHAESGK;VGLYTGEISTTRALDETDSPR 3 5.1 0.88128 -0.15251 0 0 0 0 8.39827 0 0 0 0 0 10.6992 0 Q9Y5I3 PCDA1_HUMAN Protocadherin alpha-1 (PCDH-alpha-1) PCDHA1 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] NYYSLVLDSALDR;VGERALSNYVSVHAESGK 2 3.3 0.82595 -0.020415 0 0 0 0 0 0 0 0 9.07031 0 0 0 Q9Y5I4 PCDC2_HUMAN Protocadherin alpha-C2 (PCDH-alpha-C2) PCDHAC2 Homo sapiens (Human) cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; serotonergic neuron axon guidance [GO:0036515] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ILPDTQRHVKSPR;LRRPMPWLLLLPLLLLLLLLLPGPAASQLR;NEAVSQNEVR 3 6 0.95478 -0.79855 0 5.92787 0 0 0 0 10.9265 0 0 0 0 0 Q9Y5J1 UTP18_HUMAN U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) UTP18 WDR50 CDABP0061 CGI-48 Homo sapiens (Human) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] RKTSSDDESEEDEDDLLQR;TNPKIQSIYLER;TSSDDESEEDEDDLLQR 3 5.6 0.96169 -1.0709 0 0 6.81378 0 0 0 0 6.72697 0 10.3927 0 0 Q9Y5J3 HEY1_HUMAN Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1) HEY1 BHLHB31 CHF2 HERP2 HESR1 HRT1 Homo sapiens (Human) angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; atrioventricular valve formation [GO:0003190]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle morphogenesis [GO:0003208]; circulatory system development [GO:0072359]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; umbilical cord morphogenesis [GO:0036304]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" ECLAEVAR;LVPSAFEKQVMEQGSAK;QVMEQGSAK;RLVPSAFEK 4 8.4 0.97916 -1.9132 0 0 0 10.5903 6.62183 0 0 0 0 0 0 0 Q9Y5J7 TIM9_HUMAN Mitochondrial import inner membrane translocase subunit Tim9 TIMM9 TIM9 TIM9A TIMM9A Homo sapiens (Human) protein insertion into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; zinc ion binding [GO:0008270] LTETCFLDCVK 1 12.4 0.93193 -0.49092 0 0 0 0 0 0 0 0 8.76358 0 0 0 Q9Y5K1 SPO11_HUMAN Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35) SPO11 Homo sapiens (Human) double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] "chromosome, telomeric region [GO:0000781]; nuclear chromosome [GO:0000228]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; metal ion binding [GO:0046872] LLDDNFCNK;LLDDNFCNKLSPCIMITGK;LSPCIMITGK 3 4.8 0.96349 -1.0981 0 0 0 0 8.60463 0 0 0 0 0 0 8.64147 Q9Y5K3 PCY1B_HUMAN Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) CDP-choline pathway [GO:0006657]; ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210] ELNVSFINEK;PVVTTDAESETGIPK;YEALRHCR 3 8.9 0.61401 0.17443 0 0 0 0 0 0 0 5.38094 0 0 0 0 Q9Y5K3 PCY1B_HUMAN Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) CDP-choline pathway [GO:0006657]; ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210] ELNVSFINEK;MVGHQECIMEEDNR;VGHQECIMEEDNR;YEALRHCR 4 9.1 0.97813 -1.5033 0 0 0 5.11632 0 0 0 0 0 0 11.9985 10.1175 Q9Y5K5 UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) UCHL5 UCH37 AD-019 CGI-70 Homo sapiens (Human) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein deubiquitination [GO:0016579]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of proteasomal protein catabolic process [GO:0061136]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; RNA binding [GO:0003723] GAQVEEIWSLEPENFEKLKPVHGLIFLFK;QQMFEFDTK 2 11.6 0.95189 -0.68392 0 8.24089 0 0 0 0 0 0 6.22518 0 0 0 Q9Y5K6 CD2AP_HUMAN CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) CD2AP Homo sapiens (Human) "actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction organization [GO:0045216]; collateral sprouting [GO:0048668]; D-glucose import [GO:0046323]; endothelium development [GO:0003158]; ERK1 and ERK2 cascade [GO:0070371]; filopodium assembly [GO:0046847]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; localization of cell [GO:0051674]; lymph node development [GO:0048535]; maintenance of blood-brain barrier [GO:0035633]; male gonad development [GO:0008584]; membrane organization [GO:0061024]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor signaling pathway [GO:0038180]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; podocyte differentiation [GO:0072112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein secretion [GO:0050714]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; Rab protein signal transduction [GO:0032482]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of synaptic plasticity [GO:0048167]; renal albumin absorption [GO:0097018]; response to glial cell derived neurotrophic factor [GO:1990790]; response to insulin [GO:0032868]; response to oxidative stress [GO:0006979]; response to transforming growth factor beta [GO:0071559]; response to virus [GO:0009615]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; substrate-dependent cell migration, cell extension [GO:0006930]; synapse organization [GO:0050808]; T cell receptor signaling pathway [GO:0050852]; transforming growth factor beta1 production [GO:0032905]" actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; slit diaphragm [GO:0036057]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200] ANTTAFLTPLEIK;ETGEAGWWR;TQSVEITKTDTEGK 3 5.6 0.97456 -2.3924 0 0 8.19952 0 0 0 0 0 0 8.98157 0 0 Q9Y5K8 VATD_HUMAN V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) ATP6V1D ATP6M VATD Homo sapiens (Human) cilium assembly [GO:0060271]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; protein localization to cilium [GO:0061512]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "centrosome [GO:0005813]; cilium [GO:0005929]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" KKSDALTLR 1 3.6 0.97799 -1.5054 0 0 0 0 0 0 0 0 0 0 11.5785 0 Q9Y5L0 TNPO3_HUMAN Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR) TNPO3 IPO12 Homo sapiens (Human) protein import into nucleus [GO:0006606] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635] identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] ERASFWLGELQR;IFTELCETFLEK;LGEHLYK 3 3.4 0.94102 -0.58854 0 10.0625 0 0 0 0 0 0 0 7.77215 0 0 Q9Y5M8 SRPRB_HUMAN Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) SRPRB PSEC0230 Homo sapiens (Human) "protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785] GTP binding [GO:0005525] RSSQRAVLLVGLCDSGK;VEFLECSAK 2 9.6 0.96296 -1.0821 0 4.65277 0 0 0 0 10.5981 0 0 0 0 0 Q9Y5N6 ORC6_HUMAN Origin recognition complex subunit 6 ORC6 ORC6L Homo sapiens (Human) DNA replication initiation [GO:0006270] cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808] DNA binding [GO:0003677] KIVVEAPAKEMEK 1 5.2 0.86439 -0.089923 0 0 0 0 0 0 0 0 0 10.9753 0 0 Q9Y5P3 RAI2_HUMAN Retinoic acid-induced protein 2 RAI2 Homo sapiens (Human) animal organ development [GO:0048513]; embryo development ending in birth or egg hatching [GO:0009792] nucleus [GO:0005634] KALVTVPAPSILNPPAESQSGMALK 1 4.7 0.36945 0.22753 0 10.2107 0 0 0 0 0 0 0 0 0 0 Q9Y5P4 CERT_HUMAN Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) CERT1 CERT COL4A3BP STARD11 Homo sapiens (Human) cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; endoplasmic reticulum organization [GO:0007029]; ER to Golgi ceramide transport [GO:0035621]; heart morphogenesis [GO:0003007]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; intermembrane lipid transfer [GO:0120009]; intermembrane sphingolipid transfer [GO:0120012]; lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; muscle contraction [GO:0006936]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol-4-phosphate binding [GO:0070273] DELQRDK;LAEMETFRDILCR 2 3.2 0.97819 -2.1519 9.21461 0 0 8.84919 9.29108 0 0 10.2544 0 0 0 0 Q9Y5P8 P2R3B_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PP2A subunit B isoform PR48) (Protein phosphatase 2A 48 kDa regulatory subunit) PPP2R3B PPP2R3L Homo sapiens (Human) protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888] CKLANVFFDTFFNIEK 1 2.8 0.87963 -0.15519 0 0 0 0 0 0 0 0 0 0 11.9356 0 Q9Y5Q0 FADS3_HUMAN Fatty acid desaturase 3 (FADS3) (EC 1.14.19.-) (Delta(13) fatty acid desaturase) (Delta(13) desaturase) FADS3 CYB5RP Homo sapiens (Human) lipid metabolic process [GO:0006629]; sphingolipid metabolic process [GO:0006665]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" VLESHWFVWITQMNHIPK 1 4 0.64893 0.17047 0 0 0 0 0 0 0 0 0 0 0 8.77942 Q9Y5Q3 MAFB_HUMAN Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) MAFB KRML Homo sapiens (Human) abducens nerve formation [GO:0021599]; brain segmentation [GO:0035284]; cornified envelope assembly [GO:1903575]; fat cell differentiation [GO:0045444]; inner ear morphogenesis [GO:0042472]; integrated stress response signaling [GO:0140467]; keratinocyte differentiation [GO:0030216]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; protein processing [GO:0016485]; regulation of DNA-templated transcription [GO:0006355]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; rhombomere 5 development [GO:0021571]; rhombomere 6 development [GO:0021572]; segment specification [GO:0007379]; sensory organ development [GO:0007423]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" ELNRHLRGFTK 1 3.4 0.86392 -0.087743 9.42694 0 0 0 0 0 0 0 0 0 0 0 Q9Y5Q5 CORIN_HUMAN "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular region [GO:0005576]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] ADDNNMGNGCSQK;FFTYLHR;NGQCIPSTFQCDGDEDCK;RILGGRTSRPGR;SGQCVLASRRCDGQADCDDDSDEENCGCK 5 7.6 0.97858 -1.9228 5.69377 0 0 4.83885 12.4143 0 11.7976 0 0 0 0 0 Q9Y5Q8 TF3C5_HUMAN General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) GTF3C5 CDABP0017 Homo sapiens (Human) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797] nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] FSTSSLLLRIRK;SLWIRFGYDPRK;VLLPFIAYYMITGPWR;VLMLRPEK 4 9.2 0.97834 -2.1024 0 0 8.61996 0 10.3055 0 0 11.2395 0 0 0 0 Q9Y5Q9 TF3C3_HUMAN General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797] fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] HHRFCLRLMLK;QAIFCYTKALK 2 2.5 0.98047 -1.666 0 0 0 0 0 0 0 0 0 10.0434 0 0 Q9Y5R2 MMP24_HUMAN Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24] MMP24 MT5MMP Homo sapiens (Human) cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; collagen catabolic process [GO:0030574]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; extracellular matrix organization [GO:0030198]; glial cell differentiation [GO:0010001]; neuronal stem cell population maintenance [GO:0097150]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DRWFWRLR;IDAAYER;IDAAYERADGRFVFFK;LSVEPGYPR;VGELDTR;VGELDTRK;YALTGQK 7 7.4 0.97548 -4.217 0 11.5647 0 0 0 0 0 0 9.90247 9.57664 0 0 Q9Y5R5 DMRT2_HUMAN Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2) DMRT2 DSXL2 Homo sapiens (Human) embryonic skeletal system development [GO:0048706]; myotome development [GO:0061055]; positive regulation of myotome development [GO:2000287]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GLSGKQNNFER;MADPQAGSAAGDWEIDVESLELEEDVCGAPR;YTFTIDR 3 8.7 0.97854 -2.0758 0 0 0 9.53599 0 0 0 0 0 8.73149 0 0 Q9Y5R6 DMRT1_HUMAN Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1) DMRT1 DMT1 Homo sapiens (Human) cell morphogenesis [GO:0000902]; germ cell migration [GO:0008354]; intracellular signal transduction [GO:0035556]; male germ cell proliferation [GO:0002176]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; meiosis I [GO:0007127]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of male gonad development [GO:2000020]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nodal signaling pathway [GO:1900107]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FCMWRDCQCK 1 2.7 0.92779 -0.45791 0 0 0 0 0 3.95624 0 0 0 0 0 0 Q9Y5R8 TPPC1_HUMAN Trafficking protein particle complex subunit 1 (BET5 homolog) (Multiple myeloma protein 2) (MUM-2) TRAPPC1 BET5 MUM2 Homo sapiens (Human) COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] KQAGIPK 1 4.8 0.91808 -0.40818 0 0 11.3168 0 0 0 0 0 0 0 0 0 Q9Y5S1 TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) TRPV2 VRL Homo sapiens (Human) calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to temperature stimulus [GO:0009266]; sensory perception [GO:0007600] axonal growth cone [GO:0044295]; cell body [GO:0044297]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; melanosome [GO:0042470]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; monoatomic ion channel activity [GO:0005216]; monoatomic ion transmembrane transporter activity [GO:0015075] GFQHTGIYSVMIQK;HRMVVLEPLNKLLQAK;KGTGASQPDPNR;LLQAKWDLLIPK;SLQCVKLLVENGANVHAR;YLTDSEYTEGSTGKTCLMK 6 11.3 0.98028 -1.5549 0 0 0 0 0 10.3716 0 0 3.23057 0 7.93858 11.6597 Q9Y5S2 MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) CDC42BPB KIAA1124 Homo sapiens (Human) actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; establishment or maintenance of cell polarity [GO:0007163]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] ALSNSNR;IADSNRLER;LELQSALEAEIR;LEQEKLELSR;LICSRERR;LILCYEIQR;RAETACFR 7 3.7 0.97219 -2.6981 0 0 11.432 0 9.23872 0 0 0 0 11.0871 0 0 Q9Y5S8 NOX1_HUMAN NADPH oxidase 1 (NOX-1) (EC 1.6.3.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1) NOX1 MOX1 NOH1 Homo sapiens (Human) angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to hyperoxia [GO:0071455]; defense response [GO:0006952]; extracellular matrix organization [GO:0030198]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; NADP metabolic process [GO:0006739]; oxygen metabolic process [GO:0072592]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of JNK cascade [GO:0046330]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; superoxide anion generation [GO:0042554] anchoring junction [GO:0070161]; cell projection [GO:0042995]; early endosome [GO:0005769]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; NADP binding [GO:0050661]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] AAGDWTENLIR;CAESFEMWDDRDSHCR;QLDHNLTFHK;VGFLNYR;VQFYFNK 5 9 0.97842 -1.5305 0 8.06711 0 0 7.50335 0 8.84289 0 9.75434 0 9.11134 0 Q9Y5S9 RBM8A_HUMAN RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) RBM8A RBM8 HSPC114 MDS014 Homo sapiens (Human) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006] mRNA binding [GO:0003729]; RNA binding [GO:0003723] GFGSEEGSR 1 5.2 0.78055 0.032403 0 0 0 0 0 0 0 0 0 0 10.1047 0 Q9Y5T4 DJC15_HUMAN DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ) DNAJC15 DNAJD1 GIG22 HSD18 Homo sapiens (Human) "cellular response to starvation [GO:0009267]; intracellular protein transport [GO:0006886]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of protein-containing complex assembly [GO:0031333]; protein import into mitochondrial matrix [GO:0030150]; protein-containing complex assembly [GO:0065003]; regulation of lipid metabolic process [GO:0019216]" "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]" ATPase activator activity [GO:0001671] LVRSLIAVGLGVAALAFAGR;RVMILNHPDK;YAFRIWKPLEQVITETAK 3 32 0.76559 0.064247 0 0 0 0 8.92288 7.58308 0 0 0 0 8.36006 9.38752 Q9Y5T5 UBP16_HUMAN Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) USP16 MSTP039 Homo sapiens (Human) cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein deubiquitination [GO:0016579]; protein homotetramerization [GO:0051289]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] GVVTPKELFSQVCK;NQRRQQK;SMPSFVDR;VLNSQAYLLFYER 4 5.1 0.9726 -2.6787 0 0 0 9.46807 0 0 0 0 0 0 0 0 Q9Y5U4 INSI2_HUMAN Insulin-induced gene 2 protein (INSIG-2) INSIG2 Homo sapiens (Human) cellular response to insulin stimulus [GO:0032869]; cholesterol biosynthetic process [GO:0006695]; cranial suture morphogenesis [GO:0060363]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of steroid biosynthetic process [GO:0010894]; roof of mouth development [GO:0060021]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]; triglyceride metabolic process [GO:0006641] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937] oxysterol binding [GO:0008142]; protein sequestering activity [GO:0140311] GVVLFFIGVFLALVLNLLQIQR;VIAEKSHQE 2 13.8 0.97487 -1.3923 9.15732 5.3578 0 0 0 0 0 0 0 0 0 0 Q9Y5U5 TNR18_HUMAN Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) TNFRSF18 AITR GITR UNQ319/PRO364 Homo sapiens (Human) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] tumor necrosis factor receptor activity [GO:0005031] ALLPWQQK 1 3.1 0.93667 -0.55918 0 0 0 0 0 9.23881 0 0 0 0 0 0 Q9Y5U8 MPC1_HUMAN Mitochondrial pyruvate carrier 1 (Brain protein 44-like protein) MPC1 BRP44L CGI-129 HSPC040 PNAS-115 Homo sapiens (Human) mitochondrial pyruvate transmembrane transport [GO:0006850] inner mitochondrial membrane protein complex [GO:0098800]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] pyruvate transmembrane transporter activity [GO:0050833] MTFALCCYSLTFMR 1 12.8 0.91681 -0.34362 0 8.38249 0 0 0 0 0 0 0 0 0 0 Q9Y5U9 IR3IP_HUMAN Immediate early response 3-interacting protein 1 IER3IP1 HSPC039 Homo sapiens (Human) brain development [GO:0007420]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; organ growth [GO:0035265]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of protein secretion [GO:0050714]; protein transport [GO:0015031]; regulation of fibroblast apoptotic process [GO:2000269] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] VPLIIVNSIAIVLLLLFG 1 22 0.68624 0.16372 0 0 0 0 0 0 0 0 0 0 4.16752 0 Q9Y5V0 ZN706_HUMAN Zinc finger protein 706 ZNF706 HSPC038 PNAS-113 Homo sapiens (Human) negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] TPLPPELADVQA 1 15.8 0.88198 -0.1588 0 7.47086 0 0 0 0 0 0 0 0 0 0 Q9Y5V3 MAGD1_HUMAN Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) MAGED1 NRAGE PP2250 PRO2292 Homo sapiens (Human) circadian regulation of gene expression [GO:0032922]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713] DVPNTQPKAAFKSQNATPK;QKYLDYR;VPNSNPPEYEFLWGLRSYHETSKMK;VQNATTK 4 7.5 0.97666 -2.2022 0 0 0 0 0 0 11.9445 0 0 0 7.15411 13.5095 Q9Y5W3 KLF2_HUMAN Krueppel-like factor 2 (Lung krueppel-like factor) KLF2 LKLF Homo sapiens (Human) cell morphogenesis [GO:0000902]; cellular response to cycloheximide [GO:0071409]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to peptide [GO:1901653]; cellular response to tumor necrosis factor [GO:0071356]; cellular stress response to acid chemical [GO:0097533]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte maturation [GO:0043249]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; type I pneumocyte differentiation [GO:0060509]; vasodilation [GO:0042311] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FARSDELTRHYR;TATHTCSYAGCGKTYTK 2 8.2 0.86572 -0.089165 0 6.72055 7.34012 0 0 0 0 0 0 0 6.27698 0 Q9Y5W5 WIF1_HUMAN Wnt inhibitory factor 1 (WIF-1) WIF1 UNQ191/PRO217 Homo sapiens (Human) anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of Wnt signaling pathway [GO:0030178]; nodal signaling pathway [GO:0038092]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; extracellular region [GO:0005576] activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; Wnt-protein binding [GO:0017147] CQCQEGWHGR;CQCQEGWHGRHCNK 2 3.7 0.83177 -0.026607 0 0 8.39133 0 0 7.01881 0 0 0 0 0 0 Q9Y5W7 SNX14_HUMAN Sorting nexin-14 SNX14 Homo sapiens (Human) autophagosome maturation [GO:0097352]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein transport [GO:0015031] cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynapse [GO:0098794] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" AENTERK;DAIFCENTEPR;IPVFCIDVER;IPVFCIDVERNDRR;RGESFGISR;RIHKVDIPSIITK 6 5.7 0.98056 -1.6374 0 0 0 0 9.8993 9.91362 7.82769 10.6486 0 9.65046 0 0 Q9Y5W8 SNX13_HUMAN Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1) SNX13 KIAA0713 Homo sapiens (Human) intracellular protein transport [GO:0006886]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547] early endosome [GO:0005769]; early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266] DYVQYWYYTLSDDESFLLEIR;IQRLQSGKEINTVK;VCDSRIQR;VMLLLMDEVFDLKERNQWLR;VPPLIPK 5 6.9 0.96542 -1.2149 0 5.57189 0 2.42929 6.18311 0 7.47054 0 10.4022 0 0 3.50703 Q9Y5X1 SNX9_HUMAN Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) SNX9 SH3PX1 SH3PXD3A Homo sapiens (Human) cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; lipid tube assembly [GO:0060988]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of GTPase activity [GO:0043547]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein kinase activity [GO:0045860]; protein-containing complex assembly [GO:0065003]; receptor-mediated endocytosis [GO:0006898]; regulation of synaptic vesicle endocytosis [GO:1900242] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle [GO:0001726]; trans-Golgi network [GO:0005802] 1-phosphatidylinositol binding [GO:0005545]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625] DLHFLMECNHEYK;MERLQAWMTRMCR 2 4.4 0.7659 0.064281 0 0 0 3.76543 0 0 0 0 0 0 7.41574 0 Q9Y5X2 SNX8_HUMAN Sorting nexin-8 SNX8 Homo sapiens (Human) early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] AERIASRAIDNAADLLIFGK;HPLFSEDVVLK;IVEQENAIQTMELR 3 9.7 0.91593 -0.3661 0 0 0 0 0 5.34536 0 0 0 0 5.61762 0 Q9Y5X3 SNX5_HUMAN Sorting nexin-5 SNX5 Homo sapiens (Human) "epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; negative regulation of blood pressure [GO:0045776]; pinocytosis [GO:0006907]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" "brush border [GO:0005903]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; macropinocytic cup [GO:0070685]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; ruffle [GO:0001726]; tubular endosome [GO:0097422]" "cadherin binding [GO:0045296]; D1 dopamine receptor binding [GO:0031748]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" AAVPELLQQQEEDR;HARNNVSLLQSCIDLFK 2 7.7 0.89736 -0.23928 0 0 0 0 0 0 0 0 0 9.0117 0 8.04034 Q9Y5X4 NR2E3_HUMAN Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) NR2E3 PNR RNR Homo sapiens (Human) cell population proliferation [GO:0008283]; eye photoreceptor cell development [GO:0042462]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" LLLLLPSLRFITAER 1 3.7 0.9198 -0.43847 0 0 0 0 0 0 5.92979 0 0 0 0 0 Q9Y5X5 NPFF2_HUMAN Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408] actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628] DRTCCCRR;ERFIMNEK;LGLSRQTAK;QSAGDRR 4 6.1 0.98174 -1.5828 0 0 0 0 0 10.0755 0 0 0 0 0 0 Q9Y5X5 NPFF2_HUMAN Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408] actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628] DRTCCCRR;LGLSRQTAK;QSAGDRR;RERMAIWK 4 24.2 0.97472 -3.1154 0 9.67629 0 12.0406 0 0 0 0 0 0 8.52101 0 Q9Y5X9 LIPG_HUMAN Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32) LIPG UNQ387/PRO719 Homo sapiens (Human) cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; regulation of lipoprotein metabolic process [GO:0050746]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433] cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triacylglycerol lipase activity [GO:0004806] IQLTWEGASQSWYNLWKEFR;LHKPKATQTEVKPSVRFNLR 2 8 0.9304 -0.4689 0 0 0 0 0 0 0 11.198 0 0 0 11.1787 Q9Y5Y0 FLVC1_HUMAN Choline/ethanolamine transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR) (Heme transporter FLVCR1) FLVCR1 FLVCR Homo sapiens (Human) blood vessel development [GO:0001568]; choline transport [GO:0015871]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; head morphogenesis [GO:0060323]; heme biosynthetic process [GO:0006783]; heme export [GO:0097037]; heme transport [GO:0015886]; in utero embryonic development [GO:0001701]; intracellular iron ion homeostasis [GO:0006879]; mitochondrial transport [GO:0006839]; multicellular organism growth [GO:0035264]; phospholipid biosynthetic process [GO:0008654]; regulation of organ growth [GO:0046620]; spleen development [GO:0048536] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232] IGLTLVVAGMVGSILCGLWLDYTK;TVMLSKQSESAI 2 6.5 0.96457 -1.1528 0 0 0 0 0 0 0 8.95079 0 0 0 0 Q9Y5Y5 PEX16_HUMAN Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) PEX16 Homo sapiens (Human) ER-dependent peroxisome localization [GO:0106101]; ER-dependent peroxisome organization [GO:0032581]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein to membrane docking [GO:0022615] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] LPVSLSQQK;WLVIALVQLAKAVLRMLLLLWFK 2 9.5 0.87812 -0.13792 0 0 0 6.32023 0 0 0 0 0 0 0 6.74079 Q9Y5Y6 ST14_HUMAN Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] CDGWADCTDHSDELNCSCDAGHQFTCKNK;DDCGDGSDEASCPK;EDCSDGSDEK 3 6.2 0.95577 -0.98807 0 0 0 0 7.20095 5.06514 0 0 0 0 0 0 Q9Y5Y9 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) SCN10A Homo sapiens (Human) AV node cell action potential [GO:0086016]; bundle of His cell action potential [GO:0086043]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during action potential [GO:0086010]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception [GO:0007600]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; clathrin complex [GO:0071439]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated sodium channel complex [GO:0001518] transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248] KLGSKKPQKPIPRPLNK;KNISAPHEDWPR;KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIK;TLRALRPLRALSR;VLRALKTVSVIPGLK 5 4.8 0.35138 0.23488 9.44101 0 0 0 0 8.36339 0 8.00163 0 5.71981 0 0 Q9Y5Z0 BACE2_HUMAN Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852 Homo sapiens (Human) amyloid-beta metabolic process [GO:0050435]; glucose homeostasis [GO:0042593]; melanosome organization [GO:0032438]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] aspartic-type endopeptidase activity [GO:0004190] DENSSRSFRITILPQK;FPGLSQQRM;ITILPQKLQVLQCLK 3 8.3 0.95521 -0.93689 0 0 0 6.55076 0 0 0 0 0 0 9.49368 0 Q9Y5Z4 HEBP2_HUMAN Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739] heme binding [GO:0020037] NNEVWLIQK 1 4.4 0.9093 -0.27901 0 0 0 0 0 0 11.3828 0 0 0 0 0 Q9Y5Z6 B3GT1_HUMAN "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Homo sapiens (Human) galactosylceramide biosynthetic process [GO:0006682]; lipid glycosylation [GO:0030259]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] "glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity [GO:0047275]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" TLMGMRWVATFCSK;TLMGMRWVATFCSKAK 2 4.9 0.60705 0.17619 0 9.59049 0 0 0 0 0 0 0 0 0 5.01024 Q9Y5Z7 HCFC2_HUMAN Host cell factor 2 (HCF-2) (C2 factor) HCFC2 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; chromatin remodeling [GO:0006338]; immune response involved in response to exogenous dsRNA [GO:1902615]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of toll-like receptor 3 signaling pathway [GO:0034139]; regulation of transcription by RNA polymerase II [GO:0006357]; viral process [GO:0016032] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Set1C/COMPASS complex [GO:0048188] transcription coactivator activity [GO:0003713] ISAKNEK;LYFWSGRDGYK;WLQGNNKK 3 3.3 0.97255 -2.8155 12.9851 13.103 0 0 0 0 0 0 0 0 0 4.62147 Q9Y5Z9 UBIA1_HUMAN UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Transitional epithelial response protein 1) UBIAD1 TERE1 Homo sapiens (Human) "menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371]; vitamin K metabolic process [GO:0042373]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] antioxidant activity [GO:0016209]; prenyltransferase activity [GO:0004659] SQAFNKLPQRTAK 1 3.8 0.95523 -0.8624 0 0 0 9.82515 0 0 0 0 0 0 0 0 Q9Y600 CSAD_HUMAN Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) L-cysteine catabolic process to hypotaurine [GO:0019449]; L-cysteine catabolic process to taurine [GO:0019452]; taurine biosynthetic process [GO:0042412] cytoplasm [GO:0005737] aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782] GTSVSQK;SQGESQK 2 2.8 0.91581 -0.39138 0 4.61447 0 0 0 0 10.7114 0 0 0 11.5196 0 Q9Y603 ETV7_HUMAN Transcription factor ETV7 (ETS translocation variant 7) (ETS-related protein Tel2) (Tel-related Ets factor) (Transcription factor Tel-2) ETV7 TEL2 TELB TREF Homo sapiens (Human) animal organ morphogenesis [GO:0009887]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" APSSGDVLYELLQYIKTQRR 1 5.9 0.44465 0.19297 0 0 0 0 0 0 0 0 0 0 0 11.0421 Q9Y606 PUS1_HUMAN Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) PUS1 PP8985 Homo sapiens (Human) mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; steroid receptor RNA activator RNA binding [GO:0002153]; tRNA binding [GO:0000049]; tRNA pseudouridine(38-40) synthase activity [GO:0160147] RVTGGFNSKNR;VWLIDDILEK 2 4.9 0.95506 -0.97941 0 0 0 0 0 0 0 0 0 0 8.9233 0 Q9Y608 LRRF2_HUMAN Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) LRRFIP2 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055] LRR domain binding [GO:0030275] AEARDIRMR;QQKEEDSERAR;TLDEKSDK 3 5.6 0.96722 -1.3076 0 0 0 0 0 0 0 9.59027 0 10.2973 0 0 Q9Y613 FHOD1_HUMAN FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) FHOD1 FHOS FHOS1 Homo sapiens (Human) cortical actin cytoskeleton organization [GO:0030866]; establishment of centrosome localization [GO:0051660]; nuclear migration [GO:0007097]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stress fiber assembly [GO:0051492] bleb [GO:0032059]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] ERVLQQQQK;GRMITETEK;LTHFLDQCARR;TVKLFWR 4 3.1 0.97445 -3.8675 0 10.1128 10.6374 0 0 0 0 0 0 0 0 0 Q9Y614 ACL7B_HUMAN Actin-like protein 7B (Actin-like-7-beta) ACTL7B Homo sapiens (Human) actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] ELSLLCPGDSPAVAAAPERK;VDYELPDGK 2 7 0.92869 -0.4632 8.70915 0 0 0 0 0 0 0 0 0 0 0 Q9Y616 IRAK3_HUMAN Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) IRAK3 Homo sapiens (Human) cytokine-mediated signaling pathway [GO:0019221]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of macrophage tolerance induction [GO:0010933]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex disassembly [GO:0043244]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] LSSSWLDVRHIEKYVDQGK;NGTLFDRLQCVGDTAPLPWHIR;VVLDDPK 3 8.1 0.97827 -1.9375 8.27417 0 11.24 0 8.53924 10.2609 0 0 0 0 0 9.23656 Q9Y617 SERC_HUMAN Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) PSAT1 PSA Homo sapiens (Human) L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802]; O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170] ALELNMLSLK;IINNTENLVR;QVVNFGPGPAK 3 8.4 0.90934 -0.3007 0 0 0 0 0 0 0 0 0 0 9.63704 0 Q9Y618 NCOR2_HUMAN "Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)" NCOR2 CTG26 Homo sapiens (Human) cerebellum development [GO:0021549]; estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of ketone metabolic process [GO:0010565]; response to estradiol [GO:0032355] chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear retinoid X receptor binding [GO:0046965]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714] AEKKEGGSGR;EDSLPKGHVIYEGK;EPTPRLQEGSLSSSK;GKDAEAAEATAEGALK;GLLEHGR;SDHTLTSPGGGGKAKVSGRPSSR;SLVRRSYR;TVSQCKNFYFNYK 8 4.2 0.97504 -3.3727 0 0 0 10.609 9.26137 10.5253 0 0 5.63131 6.9607 9.10669 0 Q9Y619 ORNT1_HUMAN Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) SLC25A15 ORC1 ORNT1 SP1855 Homo sapiens (Human) L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; urea cycle [GO:0000050] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] LQTMYEMETSGK 1 4 0.80811 0.011342 0 7.86251 0 0 0 0 0 0 0 0 0 0 Q9Y620 RA54B_HUMAN DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) RAD54B Homo sapiens (Human) determination of adult lifespan [GO:0008340]; double-strand break repair via homologous recombination [GO:0000724]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; RNA helicase activity [GO:0003724] AAELTCLTGLFILR;CFSNPFKSVCKPSSK;ECSSTCDK;EKECSSTCDKNEEK 4 4.7 0.95551 -0.81113 0 0 10.3977 8.25838 0 0 0 0 0 0 0 5.29748 Q9Y623 MYH4_HUMAN "Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)" MYH4 Homo sapiens (Human) actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; double-stranded RNA binding [GO:0003725]; microfilament motor activity [GO:0000146] ELEEKMVTLMQEK;ILYADFKQR;ILYADFKQRYK;MVTLMQEK;QAEEAEEQSNVNLAKFR;RQAEEAEEQSNVNLAKFR;VGNEFVTK;VLAEWKQK;VQLLHTQNTSLINTKK 9 3.8 0.9766 -2.1808 0 0 0 0 0 0 0 8.09196 8.44605 10.1417 0 8.89591 Q9Y625 GPC6_HUMAN Glypican-6 [Cleaved into: Secreted glypican-6] GPC6 UNQ369/PRO705 Homo sapiens (Human) cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of signal transduction [GO:0009966] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] coreceptor activity [GO:0015026] LEFENLVEETSHFVR;YTDQLKPFGDVPRKLK 2 5.6 0.75909 0.072245 0 11.4004 0 8.8181 0 0 0 0 0 0 0 0 Q9Y639 NPTN_HUMAN Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) NPTN SDFR1 SDR1 Homo sapiens (Human) excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic potentiation [GO:0060291]; negative regulation of cytokine production [GO:0001818]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; regulation of receptor localization to synapse [GO:1902683] cell surface [GO:0009986]; immunological synapse [GO:0001772]; postsynaptic density [GO:0014069]; presynaptic membrane [GO:0042734] cell adhesion molecule binding [GO:0050839]; type 1 fibroblast growth factor receptor binding [GO:0005105] AESFRQLWDGARK 1 3.3 0.97627 -1.4691 0 0 0 0 0 0 0 10.9342 0 0 0 0 Q9Y646 CBPQ_HUMAN Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase) CPQ LCH1 PGCP Homo sapiens (Human) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; thyroid hormone generation [GO:0006590]; tissue regeneration [GO:0042246] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; protein homodimerization activity [GO:0042803] GEESAVMLEPR;GKIVVYNQPYINYSRTVQYR 2 6.6 0.98008 -1.5586 0 0 0 0 0 0 9.6009 0 0 0 0 9.90121 Q9Y653 AGRG1_HUMAN Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083 Homo sapiens (Human) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cerebral cortex radial glia-guided migration [GO:0021801]; cerebral cortex regionalization [GO:0021796]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic stem cell homeostasis [GO:0061484]; layer formation in cerebral cortex [GO:0021819]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; neural precursor cell proliferation [GO:0061351]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell adhesion [GO:0045785]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; Rho protein signal transduction [GO:0007266]; seminiferous tubule development [GO:0072520] extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; heparin binding [GO:0008201] VPLPCRRKPR 1 1.4 0.86977 -0.10133 0 0 0 0 0 5.93652 0 0 0 0 0 0 Q9Y657 SPIN1_HUMAN Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) SPIN1 OCR SPIN Homo sapiens (Human) gamete generation [GO:0007276]; meiotic cell cycle [GO:0051321]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to chromatin [GO:0071168]; regulation of DNA-templated transcription [GO:0006355]; rRNA transcription [GO:0009303]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] AVEHMFETEDGSK 1 5 0.80636 0.011514 0 0 0 0 0 0 0 12.6368 0 0 0 0 Q9Y661 HS3S4_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4) HS3ST4 3OST4 Homo sapiens (Human) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan metabolic process [GO:0030201] Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] DIKLIVVVRNPVTR;TLDGQITMEK 2 5.3 0.58596 0.17972 0 0 0 0 0 0 8.10087 0 0 0 0 0 Q9Y662 HS3SB_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B) HS3ST3B1 3OST3B1 HS3ST3B Homo sapiens (Human) "branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity [GO:0033872] APPATPLASGK;GRTHPEIDR;LREFYRPFNLK;QLPQAIIIGVKK;TLDGQITMEK 5 13.6 0.97848 -2.0772 10.9557 10.6982 0 9.41356 10.0819 7.54944 0 0 0 4.50112 0 0 Q9Y666 S12A7_HUMAN Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) SLC12A7 KCC4 Homo sapiens (Human) cell volume homeostasis [GO:0006884]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] ISAEVEVVEMVENDISAFTYER;SGDLKDAQK;TLMMEQRSQMLK;TLMMEQRSQMLKQMQLSK 4 4.5 0.9688 -1.3318 0 0 0 9.67156 0 0 8.28077 0 0 6.6669 15.4466 0 Q9Y672 ALG6_HUMAN "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG6 My046 Homo sapiens (Human) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020] "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042281]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; glucosyltransferase activity [GO:0046527]" LFPVDRGLFEDK 1 2.4 0.92308 -0.44733 0 0 0 0 0 0 0 11.9306 0 0 0 0 Q9Y673 ALG5_HUMAN Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) ALG5 HSPC149 Homo sapiens (Human) determination of left/right symmetry [GO:0007368]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] dolichyl-phosphate beta-glucosyltransferase activity [GO:0004581] DLLFIRLRYLTGAWR;DTQCGFK;GLNDLQPWPNQMAIACGSR;ILMADADGATK 4 16 0.95307 -0.76319 0 0 0 0 9.41321 0 0 0 5.69894 0 9.10646 0 Q9Y676 RT18B_HUMAN "Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b)" MRPS18B C6orf14 HSPC183 PTD017 Homo sapiens (Human) mitochondrial translation [GO:0032543]; translation [GO:0006412] cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] DHKLHVDFRNVK 1 4.7 0.61442 0.17445 0 4.13101 0 0 0 0 0 0 0 0 0 0 Q9Y678 COPG1_HUMAN Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) COPG1 COPG Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of Golgi localization [GO:0051683]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306] COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] CVMDDDNEVR;GLGPLFK;QLEEEDGSR;SAVLQEAR;SIATLAITTLLK;SLEELPVDIILASVG;SSPEPVALTESETEYVIR 7 9 0 28.802 10.0018 9.40427 9.36229 8.45914 6.22242 0 8.37482 7.58233 8.9687 9.12448 0 0 Q9Y679 AUP1_HUMAN Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1) AUP1 Homo sapiens (Human) "ERAD pathway [GO:0036503]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipophagy [GO:0061724]; protein localization to lipid droplet [GO:1990044]; response to virus [GO:0009615]; retrograde protein transport, ER to cytosol [GO:0030970]" autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020] ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625] GFMEMNGR 1 2 0.93631 -0.55157 0 0 0 0 0 0 11.6065 0 0 0 0 0 Q9Y691 KCMB2_HUMAN "Calcium-activated potassium channel subunit beta-2 (BK channel subunit beta-2) (BKbeta2) (Hbeta2) (Calcium-activated potassium channel, subfamily M subunit beta-2) (Charybdotoxin receptor subunit beta-2) (Hbeta3) (K(VCA)beta-2) (Maxi K channel subunit beta-2) (Slo-beta-2)" KCNMB2 Homo sapiens (Human) action potential [GO:0001508]; detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; regulation of vasoconstriction [GO:0019229] plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; ion channel inhibitor activity [GO:0008200]; potassium channel regulator activity [GO:0015459] LTQYLSLLCERIQR 1 6 0.83044 -0.025709 0 0 0 6.69697 0 0 0 0 0 0 0 0 Q9Y692 GMEB1_HUMAN Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) GMEB1 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp27 protein binding [GO:0051008]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GIADVGLMEEVVCNIQK;IYEAGSENNTAVVAVETHTIHK;LGGIMLR 3 8 0.9553 -0.86085 0 10.6433 0 0 0 0 0 0 0 0 6.33294 0 Q9Y696 CLIC4_HUMAN Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) CLIC4 Homo sapiens (Human) angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chloride transport [GO:0006821]; endothelial cell morphogenesis [GO:0001886]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; fertilization [GO:0009566]; keratinocyte differentiation [GO:0030216]; multicellular organism growth [GO:0035264]; negative regulation of cell migration [GO:0030336]; regulation of cytoskeleton organization [GO:0051493]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; vacuolar acidification [GO:0007035] actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus [GO:0005902]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; oxidoreductase activity [GO:0016491] FSTRKFLDGNEMTLADCNLLPK;HPESNTAGMDIFAK;YLTNAYSR 3 17.4 0.90187 -0.2622 0 0 0 0 0 0 0 0 0 0 10.8667 8.04243 Q9Y6A2 CP46A_HUMAN Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1) CYP46A1 CYP46 Homo sapiens (Human) bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; nervous system development [GO:0007399]; progesterone metabolic process [GO:0042448]; protein localization to membrane raft [GO:1903044]; regulation of long-term synaptic potentiation [GO:1900271]; sterol metabolic process [GO:0016125]; xenobiotic metabolic process [GO:0006805] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; postsynapse [GO:0098794]; presynapse [GO:0098793] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; testosterone 16-beta-hydroxylase activity [GO:0062184] FGPGAPKPRFTYFPFSLGHR;LMLEGITASR;QVGRDWVQR 3 7.8 0.98164 -1.7678 0 0 0 9.85967 10.1089 6.49954 0 0 0 0 0 0 Q9Y6A4 CFA20_HUMAN Cilia- and flagella-associated protein 20 (Basal body up-regulated protein 22) (Transcription factor IIB) CFAP20 BUG22 C16orf80 GTL3 Homo sapiens (Human) cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; sperm flagellum [GO:0036126] RNA binding [GO:0003723] ASNYQSTTR;FKNTFQSGFLSILYSIGSKPLQIWDK;IRRVYFSDR;TLGIKLPFLVMIIK 4 30.1 0.96143 -1.071 0 0 0 0 0 0 12.4448 0 0 9.99251 0 0 Q9Y6A5 TACC3_HUMAN Transforming acidic coiled-coil-containing protein 3 (ERIC-1) TACC3 ERIC1 Homo sapiens (Human) cell division [GO:0051301]; cerebral cortex development [GO:0021987]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; regulation of mitotic spindle organization [GO:0060236] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] FEEVVYQAMEEVQK;ICDDLISK;ITQEGQR;TVEQKTK 4 4.3 0.97452 -2.4026 0 0 0 0 0 3.66619 12.1826 0 0 0 12.3765 9.68233 Q9Y6A9 SPCS1_HUMAN Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) SPCS1 SPC12 HSPC033 Homo sapiens (Human) protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082]; virion assembly [GO:0019068] endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] WLPVQESSTDDKKPGER 1 10.1 0.94062 -0.60884 0 0 0 0 0 0 0 0 0 9.33869 0 0 Q9Y6B6 SAR1B_HUMAN Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) SAR1B SARA2 SARB Homo sapiens (Human) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular response to leucine starvation [GO:1990253]; COPII vesicle coating [GO:0048208]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; membrane organization [GO:0061024]; negative regulation of TORC1 signaling [GO:1904262]; regulation of COPII vesicle coating [GO:0003400]; regulation of lipid transport [GO:0032368]; regulation of TORC1 signaling [GO:1903432]; vesicle organization [GO:0016050] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765] amino acid sensor activity [GO:0140785]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] EMFGLYGQTTGK;LREMFGLYGQTTGK 2 7.1 0.95293 -0.7263 0 0 0 0 0 0 0 0 0 0 0 7.98761 Q9Y6B7 AP4B1_HUMAN AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) AP4B1 Homo sapiens (Human) intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276] LLYYCIEEEKDMAVR 1 2 0.91667 -0.43462 0 0 0 0 0 0 0 8.35103 0 0 0 0 Q9Y6C2 EMIL1_HUMAN EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of cell migration [GO:0030336]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668] extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; molecular adaptor activity [GO:0060090] LHQLSLK;LNLTAAR;LVGGQAGLGR;SNQGVAR 4 3.1 0.98002 -1.8375 0 12.9924 0 0 0 0 0 7.16862 0 0 0 0 Q9Y6C2 EMIL1_HUMAN EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of cell migration [GO:0030336]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668] extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; molecular adaptor activity [GO:0060090] LHQLSLK;LVGGQAGLGR;MADLGATKDR;SNQGVAR 4 9.8 0.97486 -1.4276 0 0 0 0 0 0 0 0 0 11.8526 0 0 Q9Y6C5 PTC2_HUMAN Protein patched homolog 2 (PTC2) PTCH2 UNQ560/PRO1121/PRO57079 Homo sapiens (Human) cell fate determination [GO:0001709]; epidermal cell fate specification [GO:0009957]; hair cycle [GO:0042633]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of cell growth [GO:0001558]; skin development [GO:0043588] plasma membrane [GO:0005886] hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; smoothened binding [GO:0005119] VLFLGLLAFGALALGLR 1 1.4 0.64 0.17325 0 0 0 7.69209 0 0 0 0 0 0 0 0 Q9Y6C9 MTCH2_HUMAN Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) MTCH2 MIMP HSPC032 Homo sapiens (Human) lipid homeostasis [GO:0055088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of stem cell differentiation [GO:2000738]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrial fusion [GO:0010635] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] membrane insertase activity [GO:0032977] ADAASQVLLGSGLTILSQPLMYVK;GLFTGLTPR;SMVQFIGR 3 13.5 0 39.123 9.66064 10.7261 11.2977 0 0 6.55019 11.1873 9.79495 11.4914 0 11.2721 0 Q9Y6D0 SELK_HUMAN Selenoprotein K (SelK) SELENOK SELK HSPC030 HSPC297 Homo sapiens (Human) calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment of localization in cell [GO:0051649]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; macrophage derived foam cell differentiation [GO:0010742]; neutrophil migration [GO:1990266]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; protein palmitoylation [GO:0018345]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein transport [GO:0051223]; respiratory burst after phagocytosis [GO:0045728]; response to oxidative stress [GO:0006979]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] MGRINHLRGPSPPPMAGGUGR 1 22.3 0.52856 0.18665 11.9915 0 0 0 0 0 0 0 0 0 0 0 Q9Y6D5 BIG2_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) ARFGEF2 ARFGEP2 BIG2 Homo sapiens (Human) endomembrane system organization [GO:0010256]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular signal transduction [GO:0035556]; positive regulation of tumor necrosis factor production [GO:0032760]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of ARF protein signal transduction [GO:0032012] asymmetric synapse [GO:0032279]; axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; symmetric synapse [GO:0032280]; trans-Golgi network [GO:0005802] GABA receptor binding [GO:0050811]; guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237] FSLLTASSSITEMKQKNIDTIK;HGLTEPER;HWWQDLFR;INDEKFK;IRLQWSRIWHVIGDHFNK;KNRSPTIR;QESQTKSMFVSRALEK;QNVASEK;TFLEGFRLPGEAQKIDR;YLSGSGR 10 6.6 0.9781 -6.9183 10.1284 8.50871 7.33494 0 8.81919 10.0393 0 7.90743 10.8081 0 12.0517 0 Q9Y6D6 BIG1_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ARFGEF1 ARFGEP1 BIG1 Homo sapiens (Human) endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802] guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237] ETKELTIPTKSSK;EVKKAHHSQLR;HWWQDLFR;ILFRMYMDESR;QNVASEK 5 2.7 0.92988 -0.47507 0 0 7.53636 0 4.457 0 0 0 6.81954 0 0 8.28702 Q9Y6D9 MD1L1_HUMAN Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; thymus development [GO:0048538] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear envelope [GO:0005635]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; kinetochore binding [GO:0043515] ETNGLLQEELEGLQR;SHLIQVER;VELERAASTSAR 3 4.9 0.95126 -0.68705 0 0 0 0 0 0 0 0 7.29976 0 9.51712 0 Q9Y6D9 MD1L1_HUMAN Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; thymus development [GO:0048538] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear envelope [GO:0005635]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; kinetochore binding [GO:0043515] ETNGLLQEELEGLQR;LPARGCVRK 2 3.8 0.97679 -1.4908 0 0 0 0 0 0 0 0 0 0 9.40996 0 Q9Y6E0 STK24_HUMAN Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; execution phase of apoptosis [GO:0097194]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of cell migration [GO:0030336]; positive regulation of axon regeneration [GO:0048680]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ADPEELFTK;QSAYDSK;WKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIR;YSLSGGGTSSH 4 14.4 0.9755 -2.3506 0 0 9.36464 0 0 0 0 0 0 11.8235 0 0 Q9Y6E2 5MP1_HUMAN eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) BZW2 5MP1 HSPC028 MSTP017 Homo sapiens (Human) regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; membrane [GO:0016020] cadherin binding [GO:0045296] DANSVTSSLR;EELVAEQALK;ELSDFLRVQQSLGTRK;QSVDHFAK 4 10.5 0.96579 -1.1478 0 11.1429 10.8669 0 0 0 0 0 0 10.9157 0 0 Q9Y6E7 SIR4_HUMAN "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)" SIRT4 SIR2L4 Homo sapiens (Human) cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; epigenetic regulation of gene expression [GO:0040029]; glutamine metabolic process [GO:0006541]; mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of glutamine family amino acid metabolic process [GO:0000820]; regulation of pyruvate dehydrogenase activity [GO:1904182]; tricarboxylic acid metabolic process [GO:0072350] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] histone deacetylase activity [GO:0004407]; lipoamidase activity [GO:0061690]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD-dependent protein biotinidase activity [GO:0106420]; NAD-dependent protein lipoamidase activity [GO:0106419]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270] FILTAWEK;RPIQHGDFVRSAPIR 2 7.3 0.95472 -0.82369 0 0 0 0 0 0 0 10.026 0 5.21241 0 0 Q9Y6F1 PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 Homo sapiens (Human) DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA ligation [GO:0051106]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] catalytic activity [GO:0003824]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; nucleotidyltransferase activity [GO:0016779] LITNIFSK;LSKQQIAR;TVEEVPHPLDR 3 5.1 0.97259 -2.6736 0 0 0 0 0 0 0 13.2838 0 0 0 0 Q9Y6F6 IRAG1_HUMAN "Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1)" IRAG1 IRAG JAW1L MRVI1 Homo sapiens (Human) cGMP-mediated signaling [GO:0019934] endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529] LLEDIAVLHRLAAR;LSSRAEVVGAVR;VSVAVVPK 3 3.8 0.86923 -0.090911 0 0 0 0 0 0 11.3412 0 0 11.3029 6.40201 0 Q9Y6F8 CDY1_HUMAN Testis-specific chromodomain protein Y 1 (EC 2.3.1.48) CDY1 CDY1A; CDY1B Homo sapiens (Human) spermatogenesis [GO:0007283] nucleus [GO:0005634] histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] CVHDFNRR;DQPFIKKMHFTIR;LTAREACAK;LTWTTTSR;NITDDSRDQPFIK 5 8.1 0.97696 -2.2147 0 0 0 9.32971 0 0 10.5745 0 0 7.93145 0 11.0385 Q9Y6G9 DC1L1_HUMAN "Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)" DYNC1LI1 DNCLI1 Homo sapiens (Human) cell division [GO:0051301]; early endosome to recycling endosome transport [GO:0061502]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of vesicle-mediated transport [GO:0060627] centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; spindle pole [GO:0000922] ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; GDP binding [GO:0019003]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] IPAVVVEKDAVFIPAGWDNDKK;SRSKLPAGK 2 5.9 0.96637 -1.2815 0 0 0 0 7.86993 12.3974 0 0 0 0 0 0 Q9Y6H1 CHCH2_HUMAN Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) CHCHD2 C7orf17 AAG10 Homo sapiens (Human) cellular response to oxidative stress [GO:0034599]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037]; regulation of generation of precursor metabolites and energy [GO:0043467] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; sequence-specific DNA binding [GO:0043565] QCRLANGLA 1 6 0.98025 -1.5723 0 0 12.3434 0 0 0 0 0 0 0 0 0 Q9Y6H5 SNCAP_HUMAN Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein) SNCAIP Homo sapiens (Human) cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] CDTQNEDR;LSLEFQDAQASSRNSK 2 2.6 0.97091 -1.3408 0 0 0 0 0 0 11.6205 0 0 0 0 0 Q9Y6H8 CXA3_HUMAN Gap junction alpha-3 protein (Connexin-46) (Cx46) GJA3 Homo sapiens (Human) cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; visual perception [GO:0007601] connexin complex [GO:0005922]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077] TLFEVGFIAGQYFLYGFELKPLYR 1 5.5 0.7095 0.15634 0 0 5.57607 0 0 0 8.75077 0 0 0 0 0 Q9Y6I3 EPN1_HUMAN Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) EPN1 Homo sapiens (Human) embryonic organ development [GO:0048568]; endocytosis [GO:0006897]; female pregnancy [GO:0007565]; in utero embryonic development [GO:0001701]; negative regulation of sprouting angiogenesis [GO:1903671]; Notch signaling pathway [GO:0007219] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]; plasma membrane [GO:0005886] clathrin binding [GO:0030276]; molecular sequestering activity [GO:0140313]; phospholipid binding [GO:0005543] EERAHALK 1 1.4 0.74173 0.10256 0 0 0 0 0 0 0 0 0 7.01 0 0 Q9Y6I4 UBP3_HUMAN Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) USP3 Homo sapiens (Human) DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; histone H2B deubiquitinase activity [GO:0140936]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] VLCLHLKRFHWTAYLR;VQHTVCMDCSSYSTYCYR 2 6.5 0.40447 0.20741 5.3652 0 0 0 0 0 0 0 8.7964 0 0 0 Q9Y6I7 WSB1_HUMAN WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) WSB1 SWIP1 Homo sapiens (Human) intracellular signal transduction [GO:0035556]; protein aggregate center assembly [GO:0140454]; protein K27-linked ubiquitination [GO:0044314]; protein polyubiquitination [GO:0000209] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] AVFLWNMDK;LVPWSQCLQNFLLHGTK;TIGELLAPAAPFDKK;TVKLVPWSQCLQNFLLHGTK 4 10.5 0.91348 -0.38762 0 0 11.0808 0 9.04284 0 0 0 12.0602 10.3031 0 0 Q9Y6I8 PXMP4_HUMAN Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein) PXMP4 PMP24 Homo sapiens (Human) ether lipid metabolic process [GO:0046485] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] AAPPQLRALLVVVNALLRK;MAAPPQLRALLVVVNALLRK;YHAALAVLK 3 13.7 0.47569 0.19067 12.3713 12.8434 12.9081 0 0 0 0 0 7.0765 10.1954 0 0 Q9Y6I9 TX264_HUMAN Testis-expressed protein 264 (Putative secreted protein Zsig11) TEX264 ZSIG11 UNQ337/PRO536 Homo sapiens (Human) protein-DNA covalent cross-linking repair [GO:0106300]; reticulophagy [GO:0061709] autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; replication fork [GO:0005657] signaling receptor activity [GO:0038023] LDPGTEPLGTTKWLWEPTAPEKGK 1 7.7 0.63014 0.1736 0 0 0 0 0 0 0 9.4297 0 0 0 0 Q9Y6J0 CABIN_HUMAN Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; nucleosome assembly [GO:0006334] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein phosphatase inhibitor activity [GO:0004864] AMGHKFLVR;DADRQVLAQR;DLFEDGWLEFVVRVYWLK;GELPPELVQQMEGRRDSMLETAK;GVAYDLGRVER;IGHVALRLIRIPLAR;ISEESGETAKRR;QALIVREKEPDLK;SIVLLLKVLAQLR;SIVLLLKVLAQLRDHSTLLK 10 5.9 0.97415 -2.4106 0 8.44245 0 9.89465 4.54918 8.25385 8.90764 9.71134 8.55301 8.64789 10.548 0 Q9Y6J8 STYL1_HUMAN Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX) STYXL1 DUSP24 MKSTYX Homo sapiens (Human) intracellular signal transduction [GO:0035556]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] phosphatase inhibitor activity [GO:0019212]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; pseudophosphatase activity [GO:0001691] DDDDDSDSDGDGK 1 4.2 0.80852 0.010652 0 2.61873 0 0 2.59975 0 0 0 5.0193 0 0 0 Q9Y6J9 TAF6L_HUMAN TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) TAF6L PAF65A Homo sapiens (Human) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123] extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] GRLFQTAFPAPYGPSPASR;QQGPGTGTR 2 4.5 0.96557 -1.1229 0 0 0 0 0 0 0 0 9.21374 0 0 0 Q9Y6K1 DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) DNMT3A Homo sapiens (Human) autosome genomic imprinting [GO:0141068]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; hepatocyte apoptotic process [GO:0097284]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cellular response to hypoxia [GO:1900039]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] "catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]" "chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]" AGDDEPEYEDGR;AVENGCCTPK;DISRFLESNPVMIDAK;FSVVCVEK;NCFLECAYQYDDDGYQSYCTICCGGR;RDEWLAR 6 8.7 0.96234 -1.0777 0 8.55559 0 0 0 0 0 0 0 0 0 0 Q9Y6K1 DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) DNMT3A Homo sapiens (Human) autosome genomic imprinting [GO:0141068]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; hepatocyte apoptotic process [GO:0097284]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cellular response to hypoxia [GO:1900039]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] "catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]" "chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]" AGDDEPEYEDGR;DISRFLESNPVMIDAK;FSVVCVEK;NCFLECAYQYDDDGYQSYCTICCGGR;SLKDECDTAEKK;VVRRNGR 6 11.2 0.9756 -2.3139 11.382 0 0 0 5.55462 0 12.6851 0 0 0 8.31161 12.752 Q9Y6K5 OAS3_HUMAN 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; MDA-5 signaling pathway [GO:0039530]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of chemokine (C-X-C motif) ligand 9 production [GO:0035395]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] HWYQQCTK;NFVNIRPAKLKNLILLVK;SDADLVVFLSCFSQFTEQGNKR 3 4.4 0.37683 0.21812 7.6164 0 0 0 0 0 0 0 0 5.73411 0 9.37473 Q9Y6K8 KAD5_HUMAN Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) AK5 Homo sapiens (Human) ADP biosynthetic process [GO:0006172]; ATP metabolic process [GO:0046034]; dADP biosynthetic process [GO:0006173]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] GFLIDGYPR;NTNDAKEYLAR;TIAKRLEAYYR 3 5.5 0.98178 -1.5889 0 0 0 7.00753 0 0 0 0 9.91442 9.85532 0 0 Q9Y6K9 NEMO_HUMAN NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) IKBKG FIP3 NEMO Homo sapiens (Human) anoikis [GO:0043276]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; establishment of vesicle localization [GO:0051650]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein-containing complex assembly [GO:0065003]; response to virus [GO:0009615]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591]; transferrin receptor binding [GO:1990459]; ubiquitin protein ligase binding [GO:0031625] IEDMRKR;LKEEAEQHK;QQLQQAEEALVAKQEVIDKLK 3 8.4 0.9793 -1.8932 0 0 0 0 0 0 0 0 0 0 7.82018 0 Q9Y6L6 SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6 Homo sapiens (Human) bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] MDQNQHLNKTAEAQPSENK 1 2.7 0.82344 -0.018923 0 0 7.42173 0 0 0 0 0 0 0 0 0 Q9Y6L7 TLL2_HUMAN Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of skeletal muscle tissue growth [GO:0048632]; protein processing [GO:0016485] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] ATTSRTER;NTFSRGVFLDTILPR;PRATALGALVSLLLLLPLPR 3 4.2 0.97692 -2.1736 0 0 0 9.10583 6.41775 10.201 0 0 0 0 0 0 Q9Y6M0 TEST_HUMAN Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21) PRSS21 ESP1 TEST1 UNQ266/PRO303 Homo sapiens (Human) proteolysis [GO:0006508]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GALLLALLLARAGLR;GARGALLLALLLARAGLR;YLGNSPYDIALVKLSAPVTYTK 3 12.7 0.81217 -0.012076 0 0 0 9.10313 0 5.0156 0 3.79119 0 0 0 0 Q9Y6M1 IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 IMP2 VICKZ2 Homo sapiens (Human) anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; RNA stabilization [GO:0043489] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] IIGHFFASQTAQRKIR;MVIITGPPEAQFK 2 4.8 0.85291 -0.079962 0 0 0 6.21512 6.37849 0 7.44485 0 0 0 6.8175 0 Q9Y6M4 KC1G3_HUMAN Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) CSNK1G3 Homo sapiens (Human) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein modification process [GO:0036211]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AHLAADR;FYKQLGSGDGIPQVYYFGPCGK 2 6.5 0.94817 -0.66372 0 9.21065 0 0 0 0 0 0 0 0 0 0 Q9Y6M5 ZNT1_HUMAN Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) SLC30A1 ZNT1 Homo sapiens (Human) cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; defense response to bacterium [GO:0042742]; detoxification of cadmium ion [GO:0071585]; detoxification of zinc ion [GO:0010312]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] "basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic postsynaptic density [GO:0099573]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; Schaffer collateral - CA1 synapse [GO:0098685]; T-tubule [GO:0030315]" calcium channel inhibitor activity [GO:0019855]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] ESALILLQTVPKQIDIRNLIK;NTFGWIR;THATQKNTFGWIR 3 6.7 0.92906 -0.4814 0 0 0 0 6.75435 8.03348 0 0 0 0 11.8518 0 Q9Y6M7 S4A7_HUMAN Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7) SLC4A7 BT NBC2 NBC2B NBC3 NBCn1 SBC2 SLC4A6 Homo sapiens (Human) auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; cellular response to growth factor stimulus [GO:0071363]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] DGEEYEWK;EELESHRAVYIGVHVPFSK;FLFLLLGPAGKAPQYHEIGR;ILYKFCR;LFGMPAK;RHHHQNEKR 6 5.8 0.979 -1.9891 0 10.4291 0 0 0 9.11134 0 3.02329 0 6.84887 0 0 Q9Y6N1 COX11_HUMAN "Cytochrome c oxidase assembly protein COX11, mitochondrial" COX11 Homo sapiens (Human) ATP biosynthetic process [GO:0006754]; intracellular monoatomic cation homeostasis [GO:0030003] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] copper ion binding [GO:0005507]; electron transfer activity [GO:0009055] IQCFCFEEQR;MGGLWRPGWRCVPFCGWR 2 10.1 0.93064 -0.48891 0 0 0 0 0 0 0 0 8.6743 0 8.22728 0 Q9Y6N6 LAMC3_HUMAN Laminin subunit gamma-3 (Laminin-12 subunit gamma) (Laminin-14 subunit gamma) (Laminin-15 subunit gamma) LAMC3 Homo sapiens (Human) astrocyte development [GO:0014002]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020] structural molecule activity [GO:0005198] CMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTAR;STGHGGRCHHCR 2 2.9 0.98061 -1.619 0 7.69843 0 0 0 0 0 11.2598 0 0 0 0 Q9Y6N7 ROBO1_HUMAN Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) ROBO1 DUTT1 Homo sapiens (Human) aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon midline choice point recognition [GO:0016199]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; nervous system development [GO:0007399]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275] GEPATLNCK;GEPATLNCKAEGRPTPTIEWYK;KVPSFTFTPTVTYQR 3 2.2 0.96438 -1.1976 0 0 0 4.76033 0 0 11.4166 8.5795 0 0 7.56932 0 Q9Y6N8 CAD10_HUMAN Cadherin-10 (T2-cadherin) CDH10 Homo sapiens (Human) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic membrane adhesion [GO:0099560] adherens junction [GO:0005912]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] FPQNTIHLRVLESSPVGTAIGSVKATDADTGK;TIHQFLLLFLFWVCLPHFCSPEIMFR;VPRSDGK 3 8.2 0.95262 -0.76963 12.316 12.2419 0 0 0 0 0 0 11.0035 0 0 6.12549 Q9Y6N9 USH1C_HUMAN Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) USH1C AIE75 Homo sapiens (Human) actin filament bundle assembly [GO:0051017]; auditory receptor cell morphogenesis [GO:0002093]; brush border assembly [GO:1904970]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; parallel actin filament bundle assembly [GO:0030046]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; regulation of microvillus length [GO:0032532]; retinal cone cell development [GO:0046549]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] apical part of cell [GO:0045177]; brush border [GO:0005903]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202] spectrin binding [GO:0030507] EQLLLPK;LAEARQR;LPLFDAIRPLIPLK;TKKTVSIK 4 4 0.97524 -2.3531 11.7608 0 0 4.29748 0 4.70929 0 11.3352 0 8.51688 0 0 Q9Y6P5 SESN1_HUMAN Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26) SESN1 PA26 SEST1 Homo sapiens (Human) cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; reactive oxygen species metabolic process [GO:0072593]; regulation of response to reactive oxygen species [GO:1901031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]" TEYLRSVK;TVVCTPEK 2 2.9 0.97921 -2.0461 0 10.4371 0 0 0 0 0 0 0 0 0 0 Q9Y6Q1 CAN6_HUMAN Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM) CAPN6 CALPM CANPX Homo sapiens (Human) microtubule bundle formation [GO:0001578]; regulation of cytoskeleton organization [GO:0051493] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; spindle microtubule [GO:0005876] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; microtubule binding [GO:0008017] LVEVFSAEK;MGRPDNYIIGFELFKVEMNR 2 4.5 0.93362 -0.49751 0 11.9383 0 0 9.58575 0 0 0 0 0 0 0 Q9Y6Q2 STON1_HUMAN Stonin-1 (Stoned B-like factor) STON1 SALF SBLF STN1 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; focal adhesion assembly [GO:0048041]; focal adhesion disassembly [GO:0120181]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; regulation of endocytosis [GO:0030100]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; synaptic vesicle [GO:0008021] clathrin adaptor activity [GO:0035615] EIQLDPYCRLSEPK;IEHVSYTEK;IGDCITQ;LEHLQSAENQDSLR;SLKAKMNR;YESAYQAVVWK;YESAYQAVVWKIDRLPDK 7 9.5 0.97219 -2.8252 0 0 3.84609 0 0 0 7.58864 9.77785 0 11.9035 0 11.573 Q9Y6Q2 STON1_HUMAN Stonin-1 (Stoned B-like factor) STON1 SALF SBLF STN1 Homo sapiens (Human) clathrin-dependent endocytosis [GO:0072583]; focal adhesion assembly [GO:0048041]; focal adhesion disassembly [GO:0120181]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; regulation of endocytosis [GO:0030100]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; synaptic vesicle [GO:0008021] clathrin adaptor activity [GO:0035615] DSNSQVDLSIR;EIQLDPYCRLSEPK;IEHVSYTEK;LEHLQSAENQDSLR;SLKAKMNR;YESAYQAVVWK;YESAYQAVVWKIDRLPDK 7 6.5 0.93508 -0.52925 0 0 11.0356 0 0 0 0 0 0 0 0 0 Q9Y6Q3 ZFP37_HUMAN Zinc finger protein 37 homolog (Zfp-37) ZFP37 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" GKRPSQGCPSK;IQTGEKHEK;QNLDLPDHSRNCVKR;QTGKKHEK 4 6.8 0.97628 -2.263 0 0 9.94999 0 0 0 0 0 8.2437 0 10.5144 0 Q9Y6Q6 TNR11_HUMAN Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) TNFRSF11A RANK Homo sapiens (Human) adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular response to zinc ion starvation [GO:0034224]; circadian temperature homeostasis [GO:0060086]; lymph node development [GO:0048535]; mammary gland alveolus development [GO:0060749]; monocyte chemotaxis [GO:0002548]; multinuclear osteoclast differentiation [GO:0072674]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031] CACTAGYHWSQDCECCR 1 2.8 0.68134 0.16527 0 0 0 0 0 0 0 5.50608 6.38569 0 0 0 Q9Y6Q9 NCOA3_HUMAN Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) NCOA3 AIB1 BHLHE42 RAC3 TRAM1 Homo sapiens (Human) cell dedifferentiation [GO:0043697]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor transactivation [GO:0035624]; regulation of stem cell division [GO:2000035]; retinoic acid receptor signaling pathway [GO:0048384]; vitamin D receptor signaling pathway [GO:0070561] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] disordered domain specific binding [GO:0097718]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; protein dimerization activity [GO:0046983]; RNA polymerase II complex binding [GO:0000993]; transcription coactivator activity [GO:0003713] ILHKLLQNGNSPAEVAK;KENNALLR;LFRNPVTNDR 3 2.5 0.97256 -2.7263 0 0 0 0 0 0 0 0 12.7188 0 0 7.25984 Q9Y6R0 NUMBL_HUMAN Numb-like protein (Numb-related protein) (Numb-R) NUMBL Homo sapiens (Human) adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; cytokine-mediated signaling pathway [GO:0019221]; lateral ventricle development [GO:0021670]; nervous system development [GO:0007399]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of neurogenesis [GO:0050769]; protein metabolic process [GO:0019538] cytoplasm [GO:0005737] AFSYICRDGTTRR;RTPSEAERWLEEVSQVAK 2 5.1 0.51673 0.18747 0 0 0 0 0 7.76845 0 0 0 0 0 0 Q9Y6R1 S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) SLC4A4 NBC NBC1 NBCE1 Homo sapiens (Human) bicarbonate transport [GO:0015701]; positive regulation of glycolytic process [GO:0045821]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293] GSLDSDNDDSDCPYSEK;LLFNFSKDNNFDYLEFR 2 3.2 0.90431 -0.26894 2.08719 0 0 0 0 0 0 0 0 0 0 9.63979 Q9Y6R4 M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomere maintenance [GO:0032206]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310] AKGEGHGR;AMDLPSFEPAFLVLCRVLLNVIHECLKLR;EVVRLMSGEFR;GQENTSGFWLNR;IVGYSTHHEHLQRQR;QPIDNSFDIQSRDCISK;TIKETADELK;TIKETADELKIFEGIK 8 6.7 0.97205 -2.6919 10.1038 6.77228 0 10.3319 0 7.86796 0 0 9.11048 6.65191 11.0481 10.2905 Q9Y6R6 Z780B_HUMAN Zinc finger protein 780B (Zinc finger protein 779) ZNF780B ZNF779 Homo sapiens (Human) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SRFEGRQGHQEGYINQK;TLGLEAFYFRNDSEYR 2 4 0.97502 -1.4351 0 0 10.8485 0 13.0902 0 0 0 0 0 0 0 Q9Y6R7 FCGBP_HUMAN IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] AEMIGSK;CFEGCECDDR;ISVAQGASK;LEQRQWK;VEARGVK;VYQSGPR 6 1.1 0.97248 -2.6796 0 10.2577 10.7655 9.56024 0 10.7573 0 9.03003 0 0 0 5.3111 Q9Y6R9 CCD61_HUMAN Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) CCDC61 Homo sapiens (Human) cell projection organization [GO:0030030]; centriole assembly [GO:0098534]; mitotic spindle assembly [GO:0090307] centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] EIQMKQQQRNR 1 2.1 0.97628 -1.4514 0 0 0 0 0 10.5207 0 0 0 0 0 0 Q9Y6T7 DGKB_HUMAN Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289] CVARAPPSCIK;IYRKFQYLLNPR;VIDKNKMQR;WAHLSPSEFSQLQK 4 5.7 0.97563 -2.3246 0 0 0 0 0 0 12.1786 0 0 0 5.23224 0 Q9Y6U3 SCIN_HUMAN Scinderin (Adseverin) SCIN KIAA1905 Homo sapiens (Human) actin filament capping [GO:0051693]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; calcium-ion regulated exocytosis [GO:0017156]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of actin nucleation [GO:0051127]; positive regulation of apoptotic process [GO:0043065]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of secretion [GO:0051047]; regulation of chondrocyte differentiation [GO:0032330]; sequestering of actin monomers [GO:0042989] actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; brush border [GO:0005903]; cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; podosome [GO:0002102] "1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" AGKQAGLQVWR;ANQVATGIRYNER;GAEYVASVLK;GFTYHLHFWLGK;LPQNSGYIWVGK 5 8.1 0.97541 -3.4386 0 0 0 0 0 0 0 10.9999 6.82553 8.7785 0 0 Q9Y6U7 RN215_HUMAN RING finger protein 215 RNF215 Homo sapiens (Human) ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VDVRLPR;VLPCKHEFHR 2 4.5 0.90414 -0.26777 0 0 0 0 0 0 8.19869 6.98448 0 0 0 0 Q9Y6V0 PCLO_HUMAN Protein piccolo (Aczonin) PCLO ACZ KIAA0559 Homo sapiens (Human) cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; presynaptic actin cytoskeleton organization [GO:0099140]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079] axon [GO:0030424]; cytoskeleton [GO:0005856]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synapse [GO:0045202] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; profilin binding [GO:0005522]; structural constituent of presynaptic active zone [GO:0098882] AEEDPMEDPYELK;AISGQLGDIRKMPPAPSGPK;DPPNFNTCTECK;FAEELEWER;GQYDDMGENMTDDPR;IESQHGIERPR;IGKMGQNGQEPVK;IISHPGPSSESK;IKQQRFAEELEWER;KDSQQDIPSSKDHK;LEELQSMKQHLLFQQEEER;LESTVLSILEAQASTLADEK;NITYKFK;QLAAELQK;QVDPVQK;SEFVDDITTRR;SISMEQLK;SPGVDPK;TAKMMQR;TLIGEACIWLDK;TVQEGKQPQTK;VDAKVEIIK 22 4.9 0.97817 -7.1389 16.7972 16.5745 16.3573 9.38746 14.952 14.8519 9.49821 9.70058 10.3183 6.55394 13.7879 11.1965 Q9Y6V7 DDX49_HUMAN Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49) DDX49 Homo sapiens (Human) positive regulation of cell growth [GO:0030307]; regulation of rRNA stability [GO:0044357]; rRNA processing [GO:0006364] nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] QPTPVQLGCIPAILEGR 1 3.5 0.5708 0.18194 0 0 0 0 0 10.0913 0 0 0 0 0 0 Q9Y6W3 CAN7_HUMAN Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) CAPN7 PALBH Homo sapiens (Human) positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541] DNSFRMLYQR;KVYYPADPPPYIDGIR;NPWSHLRWKGR;WGKLPLSPKQK 4 5.9 0.97823 -2.0611 0 0 0 0 6.72274 12.851 0 0 10.7971 13.8681 0 0 Q9Y6W6 DUS10_HUMAN Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) DUSP10 MKP5 Homo sapiens (Human) dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelium regeneration [GO:1905042]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; negative regulation of stress-activated MAPK cascade [GO:0032873]; oligodendrocyte differentiation [GO:0048709]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of adaptive immune response [GO:0002819]; regulation of brown fat cell differentiation [GO:0090335]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; JUN kinase binding [GO:0008432]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase p38 binding [GO:0048273]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" GLFNYKRLPATDSNK;ITVLDLISCREGKDSFK;SLNCGCSSASCCTVATYDK 3 10.6 0.95526 -0.83157 0 8.18611 0 8.98359 0 0 0 0 7.62352 5.55004 0 10.4265 Q9Y6X0 SETBP_HUMAN SET-binding protein (SEB) SETBP1 KIAA0437 Homo sapiens (Human) regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800] AELPPPSEEPK;ESRETLSSSR;ILSNSEGNKK;MEPEEEDELGSGR;NLDHVNK;REIEAIQCEVR 6 3.9 0.97522 -3.2897 0 0 0 0 0 0 12.8366 0 0 0 10.8805 11.7791 Q9Y6X2 PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3) PIAS3 Homo sapiens (Human) negative regulation of gene expression [GO:0010629]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] chromatin [GO:0000785]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] IKELYRR;KHELLAKALHLLK 2 3.2 0.87571 -0.12922 0 0 0 0 0 0 0 0 6.47601 0 5.76622 0 Q9Y6X6 MYO16_HUMAN Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) cerebellum development [GO:0021549]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] cytoplasm [GO:0005737]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein phosphatase binding [GO:0019903] HLTCRAGASRATLDSR;HTIQIAEFFRDLLAKSLYSR;KGTSTFLQRLER;LLKEGADPHTLVSSGGSLLHLCAR;LRSEMNAPYHK;QPPPKPK 6 4.8 0.97289 -2.953 10.7541 0 0 8.02087 10.7416 5.53375 0 5.28965 0 6.83378 0 0 Q9Y6X8 ZHX2_HUMAN Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) ZHX2 AFR1 KIAA0854 RAF Homo sapiens (Human) mRNA catabolic process [GO:0006402]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; somatic stem cell population maintenance [GO:0035019] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" ADAKKVPK;LCEEDLEKLVTRVK;STTPCMVR;VGSEPAK 4 4.4 0.94211 -0.62034 10.3249 10.9965 0 0 0 10.0004 0 0 0 0 8.86009 0 Q9Y6X9 MORC2_HUMAN ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) MORC2 KIAA0852 ZCWCC1 Homo sapiens (Human) chromatin remodeling [GO:0006338]; constitutive heterochromatin formation [GO:0140719]; DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; transposable element silencing by heterochromatin formation [GO:0141005] cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] AMGEHLAQYWKDIAIAQR;DLDGMFIYNCSR;KEDTMTCLFLSR;LSPATPSRK;VTAVEVGKHVVRWK 5 6.3 0.88682 -0.19119 0 0 12.2651 0 9.64719 0 5.29855 9.7024 0 0 0 0 Q9Y6Y0 NS1BP_HUMAN Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) IVNS1ABP ARA3 FLARA3 KIAA0850 KLHL39 NS1 NS1BP HSPC068 Homo sapiens (Human) intrinsic apoptotic signaling pathway [GO:0097193]; mRNA processing [GO:0006397]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription by RNA polymerase III [GO:0006383] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; transcription regulator complex [GO:0005667] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] KPPRENGHK 1 1.4 0.90288 -0.26324 0 0 0 0 0 0 0 10.8765 0 0 0 0 Q9Y6Y1 CMTA1_HUMAN Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) neuromuscular process controlling balance [GO:0050885]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; sequence-specific DNA binding [GO:0043565]; transcription coregulator activity [GO:0003712] ELYEAAR;IFLPKKLLECLPK;MWRAEGK 3 1.6 0.97897 -1.9607 0 0 0 8.68261 0 0 0 0 3.23996 0 0 0 Q9Y6Y8 S23IP_HUMAN SEC23-interacting protein (p125) SEC23IP MSTP053 Homo sapiens (Human) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] metal ion binding [GO:0046872]; RNA binding [GO:0003723] AAYWEEEPAEVRRCTWFYK;VGMLNGGRR 2 2.8 0.92907 -0.46157 10.4797 9.71065 10.1149 0 0 0 0 0 0 0 9.02145 0 Q9Y6Y9 LY96_HUMAN Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2) LY96 ESOP1 MD2 Homo sapiens (Human) cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] endosome membrane [GO:0010008]; extracellular region [GO:0005576]; lipopolysaccharide receptor complex [GO:0046696]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; Toll-like receptor 4 binding [GO:0035662] EVICRGSDDDYSFCR;GIKFSKGK 2 14.4 0.93625 -0.53366 0 0 0 0 0 0 0 0 0 0 9.42916 0 U3KPV4 A3LT2_HUMAN "Alpha-1,3-galactosyltransferase 2 (EC 2.4.1.87) (Isoglobotriaosylceramide synthase) (iGb3 synthase) (iGb3S)" A3GALT2 A3GALT2P IGBS3S Homo sapiens (Human) carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; lipid glycosylation [GO:0030259] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; vesicle [GO:0031982] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; N-acetyllactosaminide 3-alpha-galactosyltransferase activity [GO:0047276] ERRWQDVSMAR;HLEALIPMGVCPSATMSQLR;VALGPGR 3 11.2 0.95536 -0.98066 14.2836 0 16.7616 0 0 0 5.98354 0 0 0 0 0 W5XKT8 SACA6_HUMAN Sperm acrosome membrane-associated protein 6 (BACHELOR-like protein) SPACA6 SPACA6P UNQ2487/PRO5774 Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] acrosomal membrane [GO:0002080] FAGGGLR;VPAWACLLCFTTYSER 2 7.1 0.71197 0.15697 0 8.79373 0 0 0 0 0 0 0 0 0 0 W5XKT8 SACA6_HUMAN Sperm acrosome membrane-associated protein 6 (BACHELOR-like protein) SPACA6 SPACA6P UNQ2487/PRO5774 Homo sapiens (Human) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] acrosomal membrane [GO:0002080] EEDGDSEGK;GEDGDSERGEDGDSER;VPAWACLLCFTTYSER 3 16.9 0.95129 -0.69158 0 0 0 0 0 0 5.74136 0 0 4.48446 0 0